NIH RFA · NIEHS · P42
RFA-ES-27-004: Limited Competition: Superfund Hazardous Substance Research and Training Program (P42 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The National Institute of Environmental Health Sciences (NIEHS) is announcing the continuation of the Superfund Hazardous Substance Research and Training Program, referred to as Superfund Research Program (SRP) Centers. SRP Center grants will support problem-based, solution-oriented research Centers that consist of multiple, integrated projects representing both the biomedical and environmental science and engineering disciplines; as well as cores tasked with administrative (which includes Center leadership, data management, and training); translational research and engagement; and research support functions. The scope of the SRP Centers is taken directly from the Superfund Amendments and…
- NOFO number
- RFA-ES-27-004
- Type
- RFA
- Activity code
- P42
- Primary institute
- NIEHS · National Institute of Environmental Health Sciences
- Clinical trials
- Optional
- Posted
- May 19, 2026
- Opens
- Jun 1, 2026
- Expires
- Sep 26, 2028
RFA-ES-27-004 due dates
2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| September 25, 2026 * | September 25, 2026 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| September 25, 2027 * | September 25, 2027 * | Not Applicable | March 2028 | May 2028 | July 2028 |
| September 25, 2028 * | September 25, 2028 * | Not Applicable | March 2029 | May 2029 | July 2029 |
What its predecessor RFA-ES-23-001 funded
RFA-ES-27-004 reissues RFA-ES-23-001. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 8 projects and $41.1M in FY2022–FY2026.
Projects funded
8
Distinct projects, FY2022–FY2026
New awards
3
Type 1 (new project) award records
NIH funding
$41.1M
Award dollars under RFA-ES-23-001, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 6 | 1 | $15.3M |
| FY2026 | 8 | 2 | $25.8M |
Institutions with the most funding
- Baylor College of Medicine$5.9M · 1 project
- University of Iowa$5.8M · 1 project
- Oregon State University$5.8M · 1 project
- University of Arizona$5.8M · 1 project
- Univ of North Carolina Chapel Hill$5.6M · 1 project
- University of Southern California$4.9M · 1 project
- North Carolina State University Raleigh$4.2M · 1 project
- Emory University$3.1M · 1 project
Funding institutes
- NIEHS$41.1M · 14
Activity codes funded
- P4213 records
- R011 record
Most recent new awards
- Metabolic impacts of PFAS exposure in the Cape Fear Basin: GenX Exposure Study (opens NIH RePORTER)
North Carolina State University Raleigh · 1R01ES039536-01 · NIEHS · Notice Jul 28, 2026
$4.2MR01
- Community-Oriented Action, Science and Translation Superfund Center (COAST) (opens NIH RePORTER)
Emory University · 1P42ES036533-01 · NIEHS · Notice Jun 5, 2026
$3.1MP42
- Southern California Superfund Research and Training Program for PFAS Assessment, Remediation, and Prevention (ShARP) (opens NIH RePORTER)
University of Southern California · 1P42ES036506-01 · NIEHS · Notice Apr 23, 2025
$1.6MP42
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
2 NIH institutes and offices take applications under RFA-ES-27-004. Contact the program officer at the institute that fits your research before applying.
- NIEHS · National Institute of Environmental Health Sciences
- none
Related notices
Jan 23, 2026 · NOT-OD-26-031
NIH Pause on New Submissions to the NIH Human Embryonic Stem Cell Registry and Request for Information on Reducing Reliance on Human Embryonic Stem Cells in NIH-Supported Research.
Award terms
- Application types allowed
- New Renewal Resubmission The OER Glossary and the How to Apply - Application Guide provides details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Applications may request a budget for direct costs of up to 1.75 million dollars for each year.
- Project period
- Applications may propose a project period of up to 5 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- NIEHS intends to fund an estimate of up to 10 awards based on programmatic needs and availability of funds, corresponding to a total of up to approximately 22 million, for fiscal year 2027. Future year amounts will depend on annual appropriations.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of RFA-ES-23-001.
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.