NIH RFA · NIBIB · R18
RFA-EB-28-004: NextTech: Translational Development of Next-Generation Diagnostic and Therapeutic Devices (R18 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 26, 2026Editorial standards
This Notice of Funding Opportunity (NOFO) is to encourage applications from investigators to advance the development and translation of next-generation technologies to prevent, monitor, diagnose, and treat disorders within the missions of the NIH Brain Research through Advancing Innovative Neurotechnologies (BRAIN) and The Helping to End Addiction Long-term (HEAL) Initiatives. Awarded activities will facilitate the translation of new devices up to the stage of readiness for first in human (FIH) clinical trials by overcoming key challenges identified during preliminary proof-of-concept studies. The scope of the program includes technology development and optimization, and studies to prepare…
- NOFO number
- RFA-EB-28-004
- Type
- RFA
- Activity code
- R18
- Primary institute
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- Clinical trials
- Not Allowed
- Posted
- Oct 23, 2026
- Opens
- Jan 1, 2027
- Expires
- Dec 2, 2030
RFA-EB-28-004 due dates
6 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 01, 2027 | February 01, 2027 | Not Applicable | July 2027 | October 2027 | December 2027 |
| September 17, 2027 | September 17, 2027 | Not Applicable | March 2028 | May 2028 | July 2028 |
| May 26, 2028 | May 26, 2028 | Not Applicable | November 2028 | January 2029 | April 2029 |
| February 01, 2029 | February 01, 2029 | Not Applicable | July 2029 | October 2029 | December 2029 |
| September 19, 2029 | September 19, 2029 | Not Applicable | March 2030 | May 2030 | July 2030 |
| February 01, 2030 | February 01, 2030 | Not Applicable | July 2030 | October 2030 | December 2030 |
Funded projects
NIH RePORTER lists no awards under RFA-EB-28-004 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.
Participating institutes
9 NIH institutes and offices take applications under RFA-EB-28-004. Contact the program officer at the institute that fits your research before applying.
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NEI · National Eye Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCR · National Institute of Dental and Craniofacial Research
- NIDA · National Institute on Drug Abuse
- NIMH · National Institute of Mental Health
- NINDS · National Institute of Neurological Disorders and Stroke
Related notices
NIH lists no related notices for RFA-EB-28-004 yet.
Award terms
- Application types allowed
- New Resubmission The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Application budgets are not limited, but need to reflect the actual needs of the proposed project.Budgets should rarely exceed 750,000 direct costs per year.
- Project period
- Applications may request up to three years of support. However, the scope of the proposed project should determine the project period. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.NIH intends to commit an estimated total of 6,000,000 to fund approximately 8-12 awards in fiscal year 2028. Future year amounts will depend on annual appropriations. Awards issued under this NOFO are part of funds set aside to support the HEAL Helping to End Addiction…
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Other open NOFOs for R18
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. NIH Guide data refreshed October 26, 2026, RePORTER funding October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.