NIH PAR · NCI · RP1
PAR-28-014: Early-Onset Cancers: Investigating Etiology, Mechanisms, and Early Detection Strategies (RP1 Clinical Trials Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This Notice of Funding Opportunity (NOFO) invites applications that investigate the etiology of sporadic non-hereditary early-onset cancers (EOCs: ages 18 to 49 years) and the underlying biological mechanisms that play a role in these cancers to inform prevention and control strategies. The proposed research is expected to advance the understanding of the unexplained rise of cancers in young adults. More specifically, studies should focus on one or more of the following: i) identifying what environmental or lifestyle exposures are driving the increase in the incidence of non-hereditary EOCs, and how these factors vary by patient demographics; ii) examining the biological mechanisms and host…
- NOFO number
- PAR-28-014
- Type
- PAR
- Activity code
- RP1
- Primary institute
- NCI · National Cancer Institute
- Clinical trials
- Optional
- Posted
- Oct 14, 2026
- Opens
- Jan 8, 2027
- Expires
- Oct 12, 2029
PAR-28-014 due dates
9 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| February 08, 2027 | February 08, 2027 | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 08, 2027 | June 08, 2027 | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 13, 2027 | October 13, 2027 | Not Applicable | March 2028 | May 2028 | July 2028 |
| February 08, 2028 | February 08, 2028 | Not Applicable | July 2028 | October 2028 | December 2028 |
| June 08, 2028 | June 08, 2028 | Not Applicable | November 2028 | January 2029 | April 2029 |
| October 11, 2028 | October 11, 2028 | Not Applicable | March 2029 | May 2029 | July 2029 |
| February 08, 2029 | February 08, 2029 | Not Applicable | July 2029 | October 2029 | December 2029 |
| June 08, 2029 | June 08, 2029 | Not Applicable | November 2029 | January 2030 | April 2030 |
| October 11, 2029 | October 11, 2029 | Not Applicable | March 2030 | May 2030 | July 2030 |
Funded projects
NIH RePORTER lists no awards under PAR-28-014 in FY2022–FY2026, and it is a new NOFO rather than a reissue. Awards usually appear a few months after the first review cycle.
Participating institutes
2 NIH institutes and offices take applications under PAR-28-014. Contact the program officer at the institute that fits your research before applying.
- NCI · National Cancer Institute
- NIEHS · National Institute of Environmental Health Sciences
Related notices
NIH lists no related notices for PAR-28-014 yet.
Award terms
- Application types allowed
- New Resubmission Revision The OER Glossary and the How to Apply Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- For exploratory/developmental research projects, application budget is limited to 200,000 per year in direct costs.For standard research projects, application budget is limited to 500,000 per year in direct costs.Budget should reflect the actual needs of the proposed project.
- Project period
- The maximum project period is 3 years for exploratory/developmental research projects and 5 years for standard research projects. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.