NIH PAR · OD · SB1
PAR-27-098: SBIR/STTR Commercialization Readiness Pilot (CRP) Program (Parent SB1 Clinical Trial Optional)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
The Commercialization Readiness Pilot (CRP) program helps small business concerns (SBCs) move NIH-funded SBIR or STTR projects from late-stage development to commercialization. The CRP supports later-stage research and development (R&D) and/or technical assistance that Phase II and Phase IIB Strategic Breakthrough awards do not typically support. This includes:Independent replication or confirmation of key studiesIND- or IDE-enabling studiesClinical studiesManufacturing scale-up and related quality activitiesRegulatory and other specialized technical supportSBCs may subcontract (outsource) a significant amount of the work in a CRP to meet the project goals.
- NOFO number
- PAR-27-098
- Type
- PAR
- Activity code
- SB1
- Primary institute
- OD · NIH Office of the Director
- Clinical trials
- Optional
- Posted
- May 28, 2026
- Opens
- Aug 5, 2026
- Expires
- Apr 6, 2029
PAR-27-098 due dates
8 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| September 05, 2026 * | September 05, 2026 * | Not Applicable | November 2026 | January 2027 | April 2027 |
| January 05, 2027 * | January 05, 2027 * | Not Applicable | March 2027 | May 2027 | July 2027 |
| April 05, 2027 * | April 05, 2027 * | Not Applicable | July 2027 | August 2027 | December 2027 |
| September 05, 2027 * | September 05, 2027 * | Not Applicable | November 2027 | January 2028 | April 2028 |
| January 05, 2028 * | January 05, 2028 * | Not Applicable | March 2028 | May 2028 | July 2028 |
| April 05, 2028 * | April 05, 2028 * | Not Applicable | July 2028 | August 2028 | December 2028 |
| September 05, 2028 * | September 05, 2028 * | Not Applicable | November 2028 | January 2029 | April 2029 |
| January 05, 2029 * | January 05, 2029 * | Not Applicable | March 2029 | May 2029 | July 2029 |
| April 05, 2029 * | April 05, 2029 * | Not Applicable | July 2029 | August 2029 | December 2029 |
What its predecessor PAR-23-219 funded
PAR-27-098 reissues PAR-23-219. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 62 projects and $90.5M in FY2022–FY2026.
Projects funded
62
Distinct projects, FY2022–FY2026
New awards
62
Type 1 (new project) award records
NIH funding
$90.5M
Award dollars under PAR-23-219, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 22 | 22 | $15.3M |
| FY2025 | 38 | 21 | $32.9M |
| FY2026 | 42 | 19 | $42.3M |
Institutions with the most funding
- Endomet Biosciences, Inc$4.1M · 1 project
- Highland Instruments, Inc.$4.0M · 1 project
- Quspin$3.9M · 1 project
- Vivreon Biosciences, LLC$3.9M · 1 project
- Maphabit, Inc.$3.8M · 1 project
- Beam Diagnostics, Inc.$3.4M · 1 project
- Sequitur Health Corp.$3.0M · 1 project
- Helixbind, Inc.$3.0M · 1 project
Funding institutes
- NIA$20.0M · 12
- NIAID$18.5M · 19
- NIMH$9.6M · 7
- NHLBI$9.2M · 20
- NICHD$7.6M · 6
- NIGMS$5.7M · 6
- NIAAA$5.5M · 3
- NIAMS$4.9M · 10
Activity codes funded
- SB1102 records
Most recent new awards
- New cryovials with integral septum for cryopreservation of PfSPZ vaccine and PfSPZ challenge products. (opens NIH RePORTER)
Sanaria, Inc. · 1SB1AI195021-01 · NIAID · Notice Sep 18, 2026
$1.0MSB1
- CRP - Innovative 3D Printed Intravaginal Ring AnelleO-PRO, the first Single Administration of Progesterone for Infertility (opens NIH RePORTER)
Anelleo, Inc. · 1SB1HD120142-01A1 · NICHD · Notice Sep 17, 2026
$500KSB1
- Advancing the Commercialization of the Aromha Brain Health Test: Regulatory, Manufacturing, and Clinical Integration for National Deployment (opens NIH RePORTER)
Aromha, Inc. · 1SB1AG102179-01 · NIA · Notice Sep 17, 2026
$1.7MSB1
- Development of TP-317 for Ulcerative Colitis (opens NIH RePORTER)
Thetis Pharmaceuticals, LLC · 1SB1DK145287-01A1 · NIDDK · Notice Sep 17, 2026
$670KSB1
- Commercialization of a Pharmacy-Integrated AI System to Improve Medication Adherence and Reduce Hospitalizations in Dementia Care (opens NIH RePORTER)
Hido Technologies, Inc. · 1SB1AG099296-01A1 · NIA · Notice Sep 17, 2026
$2.0MSB1
- Development of Cortical Bone Mechanics Technology for Enhancing the Screening of Osteoporosis (opens NIH RePORTER)
Osteodx Inc. · 1SB1AG102185-01 · NIA · Notice Sep 17, 2026
$1.8MSB1
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
22 NIH institutes and offices take applications under PAR-27-098. Contact the program officer at the institute that fits your research before applying.
- OD · NIH Office of the Director
- NEI · National Eye Institute
- NHLBI · National Heart, Lung, and Blood Institute
- NHGRI · National Human Genome Research Institute
- NIA · National Institute on Aging
- NIAAA · National Institute on Alcohol Abuse and Alcoholism
- NIAID · National Institute of Allergy and Infectious Diseases
- NIAMS · National Institute of Arthritis and Musculoskeletal and Skin Diseases
- NIBIB · National Institute of Biomedical Imaging and Bioengineering
- NICHD · Eunice Kennedy Shriver National Institute of Child Health and Human Development
- NIDCD · National Institute on Deafness and Other Communication Disorders
- NIDCR · National Institute of Dental and Craniofacial Research
- NIDDK · National Institute of Diabetes and Digestive and Kidney Diseases
- NIEHS · National Institute of Environmental Health Sciences
- NIGMS · National Institute of General Medical Sciences
- NIMH · National Institute of Mental Health
- NINDS · National Institute of Neurological Disorders and Stroke
- NIMHD · National Institute on Minority Health and Health Disparities
- NCATS · National Center for Advancing Translational Sciences
- ORIP
- NCI · National Cancer Institute
- ORWH
Related notices
NIH lists no related notices for PAR-27-098 yet.
Award terms
- Application types allowed
- New Commercialization Readiness Program) Resubmission Commercialization Readiness Program) The OER Glossary and the How to Apply – Application Guide provide details on these application types. Only those application types listed here are allowed for the NOFO.
- Award budget
- Total funding support direct costs, indirect costs, fee) may not exceed the SBA budgetary limits for the Commercialization Readiness Pilot CRP) program. Budget guidelines vary by participating component and may be lower than the SBA budgetary limits. Total funding support normally may not exceed the guidelines in the table below. Applicants are strongly encouraged to contact program officials…
- Project period
- The scope of the proposed project should determine the project period. The maximum project period allowed is 3 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.