NIH PAR · ORIP · S10
PAR-27-022: Shared Instrumentation Grant (SIG) Program (S10 Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This Notice of Funding Opportunity (NOFO) announces the restructured Shared Instrumentation Grant (SIG) Program that consolidates three existing shared-use instrumentation programs, i.e., the Shared Instrumentation Grant program, the High-End Instrumentation Grant program, and the Basic Instrumentation Grant program. The NOFO invites applications from groups of NIH-supported investigators to purchase or upgrade a single state-of-the-art commercially available instrument or an integrated instrumentation system. The instruments purchased through the SIG Program are required to be optimally shared among the users to ensure efficient and cost-effective research operations, enable rigorous and…
- NOFO number
- PAR-27-022
- Type
- PAR
- Activity code
- S10
- Primary institute
- ORIP
- Clinical trials
- Not Allowed
- Posted
- Jun 25, 2026
- Opens
- Jun 27, 2026
- Expires
- Jul 2, 2028
PAR-27-022 due dates
2 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| New | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| July 27, 2026 | July 27, 2026 | Not Applicable | October 2026 | January 2027 | March 2027 |
| July 01, 2027 | July 01, 2027 | Not Applicable | October 2027 | January 2028 | March 2028 |
| July 01, 2028 | July 01, 2028 | Not Applicable | October 2028 | January 2029 | March 2029 |
What its predecessor PAR-24-264 funded
PAR-27-022 reissues PAR-24-264. Until awards appear under the new number, its funding history is the best guide to who wins under this program: 44 projects and $65.8M in FY2022–FY2026.
Projects funded
44
Distinct projects, FY2022–FY2026
New awards
44
Type 1 (new project) award records
NIH funding
$65.8M
Award dollars under PAR-24-264, FY2022–FY2026
Funding by fiscal year
| Fiscal year | Award records | New awards | Funding |
|---|---|---|---|
| FY2022 | 0 | 0 | $0 |
| FY2023 | 0 | 0 | $0 |
| FY2024 | 0 | 0 | $0 |
| FY2025 | 0 | 0 | $0 |
| FY2026 | 44 | 44 | $65.8M |
Institutions with the most funding
- New York Structural Biology Center$6.0M · 3 projects
- University of Minnesota$5.1M · 3 projects
- University of California Los Angeles$3.8M · 2 projects
- Johns Hopkins University$3.8M · 2 projects
- Case Western Reserve University$3.5M · 2 projects
- Massachusetts General Hospital$3.1M · 2 projects
- University of Pittsburgh at Pittsburgh$2.0M · 1 project
- Baylor College of Medicine$2.0M · 1 project
Funding institutes
- OD$65.8M · 44
Activity codes funded
- S1044 records
Most recent new awards
- NovaSeq X Plus Sequencing System (opens NIH RePORTER)
University of Southern California · 1S10OD038261-01A1 · OD · Notice Sep 18, 2026
$1.4MS10
- Coherent Raman Scattering (CRS) Microscope (opens NIH RePORTER)
University of California Los Angeles · 1S10OD040079-01 · OD · Notice Sep 17, 2026
$1.8MS10
- Critical Upgrade of 7.0T Preclinical MRI Scanner (opens NIH RePORTER)
Case Western Reserve University · 1S10OD040144-01 · OD · Notice Sep 14, 2026
$1.9MS10
- LUMICKS C-Trap optical tweezer/microfluidics/confocal system (opens NIH RePORTER)
University of Chicago · 1S10OD040245-01 · OD · Notice Sep 11, 2026
$1.2MS10
- Gyrotron 800 (opens NIH RePORTER)
Massachusetts Institute of Technology · 1S10OD040263-01 · OD · Notice Sep 11, 2026
$1.9MS10
- Acquisition of Glacios 2 to Enhance Cryo-EM Access in the Southwest (opens NIH RePORTER)
University of Arizona · 1S10OD040083-01 · OD · Notice Sep 10, 2026
$2.0MS10
FY2026 closed on September 30, 2026, but NIH keeps posting that year's awards to RePORTER for several weeks. FY2026 figures reflect records available on October 16, 2026 and may rise slightly at the next refresh.
Participating institutes
6 NIH institutes and offices take applications under PAR-27-022. Contact the program officer at the institute that fits your research before applying.
- ORIP
- NEI · National Eye Institute
- NIA · National Institute on Aging
- NIAID · National Institute of Allergy and Infectious Diseases
- NIGMS · National Institute of General Medical Sciences
- ODSS
Related notices
NIH lists no related notices for PAR-27-022 yet.
Award terms
- Application types allowed
- New Resubmission The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Applications will be accepted that request a single, commercially available instrument or an integrated instrumentation system. The minimum award is 300,000. There is no upper limit on the cost of the instrument, but the maximum award is 5,000,000. S10 awards do not allow indirect costs.
- Project period
- Awards are made for one year only. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of awards is contingent upon NIH appropriations and the submission of a sufficient number of meritorious applications.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-24-264.
- Companion NOFOs: PAR-27-021.
Other open NOFOs for S10
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.