NIH PAR · NHLBI · X01
PAR-25-447: NHLBI TOPMed: Omics Phenotypes of Heart, Lung, and Blood Disorders (X01 - Clinical Trial Not Allowed)
Reviewed by Dr. Meng ZhaoLast reviewed October 16, 2026Data refreshed October 16, 2026Editorial standards
This Notice of Funding Opportunity (NOFO) invites applications to use NHLBI-funded TransOmics for Precision Medicine (TOPMed) program to generate a large volume of integrated genetic and multi-omics data to facilitate discovery of the molecular mechanisms of Heart, Lung, Blood, and Sleep (HLBS) disorders. No funding will be provided under this NOFO. The genomic data and related phenotypic data will be deposited in a public NIH-designated controlled-access database such as the database for Genotypes and Phenotypes (dbGaP) and NHLBIs BioData Catalyst (BDC). The overall goal is to move from simply cataloguing genetic associations to understanding how genetic factors contribute to HLBS diseases…
- NOFO number
- PAR-25-447
- Type
- PAR
- Activity code
- X01
- Primary institute
- NHLBI · National Heart, Lung, and Blood Institute
- Clinical trials
- Not Allowed
- Posted
- Sep 22, 2025
- Opens
- Oct 6, 2025
- Expires
- May 9, 2028
PAR-25-447 due dates
4 application due dates remain before the NOFO expires. Dates marked * are NIH standard due dates. Check the related notices below for changes NIH made after posting.
| Application Due Date(s) | Renewal / Resubmission / Revision (as allowed) | AIDS - New/Renewal/Resubmission/Revision, as allowed | Scientific Merit Review | Advisory Council Review | Earliest Start Date |
|---|---|---|---|---|---|
| November 06, 2025 | November 06, 2025 | January 08, 2026 | March 2026 | May 2026 | July 2026 |
| February 06, 2026 | February 06, 2026 | May 8, 2026 | July 2026 | October 2026 | December 2026 |
| June 08, 2026 | June 08, 2026 | Not Applicable | November 2026 | January 2027 | April 2027 |
| October 06, 2026 | October 06, 2026 | Not Applicable | March 2027 | May 2027 | July 2027 |
| February 08, 2027 | February 08, 2027 | Not Applicable | July 2027 | October 2027 | December 2027 |
| June 08, 2027 | June 08, 2027 | Not Applicable | November 2027 | January 2028 | April 2028 |
| October 06, 2027 | October 06, 2027 | Not Applicable | March 2028 | May 2028 | July 2028 |
| February 07, 2028 | February 07, 2028 | Not Applicable | July 2028 | October 2028 | December 2028 |
Funded projects
NIH RePORTER lists no awards under PAR-25-447 in FY2022–FY2026. Awards usually appear a few months after the first review cycle.
Participating institutes
2 NIH institutes and offices take applications under PAR-25-447. Contact the program officer at the institute that fits your research before applying.
- NHLBI · National Heart, Lung, and Blood Institute
- none
Related notices
Aug 31, 2022 · NOT-OD-22-198
Implementation Changes for Genomic Data Sharing Plans Included with Applications Due on or after January 25, 2023. See Notice NOT-OD-22-198.
Aug 5, 2022 · NOT-OD-22-189
Implementation Details for the NIH Data Management and Sharing Policy. See Notice NOT-OD-22-189.
Award terms
- Application types allowed
- NewResubmission   The OER Glossary and the How to Apply - Application Guide provide details on these application types. Only those application types listed here are allowed for this NOFO.
- Award budget
- Not applicable. Funds are not awarded via this X01 resource access award.
- Project period
- The maximum project period is 3 years. NIH grants policies as described in the NIH Grants Policy Statement will apply to the applications submitted and awards made from this NOFO.
- Funds available and number of awards
- The number of projects granted access to omics assay resources is contingent upon the number of meritorious applications and the capacity of the omics centers. nbsp;NHLBI intends to approve up to 10 projects.
Summarized from the NOFO text; the full NOFO governs eligibility, budget, and review.
Related NOFOs
- Reissue of PAR-22-194.
Other open NOFOs for X01
- PAR-27-069Accelerating Discovery through Partnered Research with All of Us to Analyze Participant Biospecimens (X01 Clinical Trial Not Allowed)PM · next due Oct 30, 2026
- PAR-25-437Environmental influences on Child Health Outcomes (ECHO) Cohort Data and Biospecimen Access (X01 Clinical Trial Not Allowed)ECHO · next due Nov 4, 2026
- PAR-27-111Biological Testing Facility for Contraception & Reproductive Health (X01 Clinical Trial Not Allowed)NICHD · next due Jan 4, 2027
- PAR-27-071Discovery of the Genetic Basis of Childhood Cancers and of Congenital Anomalies: Gabriella Miller Kids First Pediatric Research Program (X01 Clinical Trial Not Allowed)RMOD · next due Jan 11, 2027
- PAR-27-051NIH Brain Development Cohorts (NBDC) and Population Assessment of Tobacco and Health (PATH) Study Biospecimen Access (X01 Clinical Trial Not Allowed)NIDA · next due Apr 15, 2027
About this page
GotGrant gathers the NOFO, its participation and change notices, and its NOSIs from the NIH Guide for Grants and Contracts, and counts funded projects from NIH RePORTER by the opportunity number each award was made under. Data refreshed October 16, 2026; the NIH Guide is the authoritative source. See our data methodology.