NIH R35 Grants — Outstanding Investigator Award

Recent R35 awards from NIH RePORTER

Examples of funded R35 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on June 9, 2026.

Example R35 projects from the sample

• Regulation of translation initiation by the epitranscriptome

  5R35GM159598-02
  Daniel Arango · NORTHWESTERN UNIVERSITY, IL · $440,000 · awarded Jun 3, 2026 · NIH

  Project Summary/Abstract My research program investigates how the epitranscriptome regulates protein synthesis and how this interplay affects cell fate decisions under normal homeostasis and stress conditions. The epitranscriptome is the collection of more than 150 chemical modifications that occur on RNA molecules and influence all steps of gene…

• Advanced quantitative analyses of long-read RNA-seq at the bulk and single-cell dimensions

  5R35GM158052-02
  Kin Fai Au · UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI · $462,833 · awarded Jun 3, 2026 · NIH

  Abstract Long-read sequencing has been demonstrated powerful for investigating gene isoforms, which could have critical biomedical roles, such as in embryogenesis, neuroscience and cancer. In the past decade, the Au lab has been at the forefront of developing novel bioinformatics software for identifying complex gene isoforms in different perspectives and…

• Protein structure and dynamics in ultra-heterogeneous environments-Renewal

  5R35GM133359-07
  Carlos Baiz · UNIVERSITY OF TEXAS AT AUSTIN, TX · $386,526 · awarded Jun 3, 2026 · NIH

  SUMMARY Hydrogen bonding in crowded environments – impact on biomolecules: Biomolecular organization in vivo is driven by crowding and heterogeneity. To date, protein structure, dynamics, and folding have been studied almost exclusively in buffer solutions, yet cellular environments are highly complex. This project seeks to characterize the driving forces…

• Oxygen and perioperative organ injury

  5R35GM145375-05
  Frederic Billings · VANDERBILT UNIVERSITY MEDICAL CENTER, TN · $432,500 · awarded Jun 3, 2026 · NIH

  Project Summary/Abstract More than 20% of patients undergoing major surgery experience acute kidney, brain, and heart injury, and these perioperative complications lead to persistent organ dysfunction, long-term morbidity, and death. My research program is investigating and manipulating mechanisms of perioperative organ injury in order to identify…

• Mechanisms of Bacterial Lysis Sensing

  5R35GM160020-02
  Andrew Bridges · CARNEGIE-MELLON UNIVERSITY, PA · $417,450 · awarded Jun 3, 2026 · NIH

  PROJECT SUMMARY Matrix-encapsulated communities of bacteria, called biofilms, are ubiquitous in the environment and are notoriously difficult to eliminate in clinical and industrial settings. Existing within biofilms offers resident cells protection from threats, such as bacteriophage attacks, phagocytosis by the host immune system, and antibiotic…

• Multiplexed Optical Sensors for Redox Profiling in Human iPSC Models of Disease and Drug Response

  1R35GM163600-01
  Andre Berndt · UNIVERSITY OF WASHINGTON, WA · $418,378 · awarded Jun 1, 2026 · NIH

  ABSTRACT / SUMMARY Reactive oxygen species (ROS) and regulation of redox pathways are critical to human health and disease, as they influence cellular metabolism, signaling, and stress responses. Disruptions in redox homeostasis contribute to the pathophysiology of numerous disorders, including neurodegenerative diseases, muscular degeneration, and…

• Molecular mechanisms that regulate vesicle formation and transport

  5R35GM134865-07
  Anjon Audhya · UNIVERSITY OF WISCONSIN-MADISON, WI · $625,888 · awarded May 29, 2026 · NIH

  PROJECT SUMMARY How the intracellular membrane system of eukaryotic cells is configured and maintained is a fundamental problem in cell biology. Deficiencies in this organization often lead to disease. The overarching goal of my laboratory is to define the molecular mechanisms that regulate membrane dynamics, including vesicle biogenesis, organelle…

• Mechanisms of evolution at the host-pathogen interface

  5R35GM158176-02
  Matthew Barber · UNIVERSITY OF OREGON, OR · $406,243 · awarded May 29, 2026 · NIH

  PROJECT SUMMARY Pathogens and their hosts impose strong selective pressure on one another, leading to the rapid evolution of host-pathogen molecular interactions. This process in turn can shape pathogen host range, virulence, and the emergence or reemergence of infectious diseases in human populations. These features also make host-pathogen interactions…

• Cytoskeletal Function in C. elegans Embryos

  5R35GM131749-08
  BRUCE BOWERMAN · UNIVERSITY OF OREGON, OR · $608,904 · awarded May 29, 2026 · NIH

  Project Summary For 30 years now, our laboratory has used live cell imaging with fluorescently marked proteins, and classical and molecular genetic approaches with the early embryo of the nematode Caenorhabditis elegans to investigate cytoskeletal function and regulation. In addition to having isolated temperature-sensitive mutations in many essential genes…

• Choreography of Eukaryotic DNA Replication

  5R35GM122497-10
  BONITA BREWER · UNIVERSITY OF WASHINGTON, WA · $571,840 · awarded May 29, 2026 · NIH

  PROJECT SUMMARY Faithful replication of the genome is a core mission of all dividing cells. Accordingly, cells have evolved mechanisms to monitor replication fidelity and to coordinate completion of replication with other cell cycle events. In eukaryotes, chromosome replication is initiated at multiple initiation sites (origins), which are a key target of…

• Regulation of mitochondrial morphology and functional versatility

  5R35GM150942-05
  HALIL AYDIN · NEW YORK UNIVERSITY, NY · $402,500 · awarded May 28, 2026 · NIH

  PROJECT SUMMARY Eukaryotic cells sequester critical biochemical reactions into discrete membranous compartments, whereby membrane dynamics driven by protein catalysts facilitate differentiation, communication, and spatial organization of intracellular compartments. Within a cell, mitochondria are mainly organized into highly interconnected networks, whose…

• Interrogating function, regulation, and interactions in a clade of prevalent human gut microbes

  5R35GM151155-04
  Patrick Bradley · OHIO STATE UNIVERSITY, OH · $385,664 · awarded May 28, 2026 · NIH

  PROJECT SUMMARY/ABSTRACT Human-associated microbes are causally linked to processes as diverse as immunomodulation, protection against pathogens, and atherosclerosis. Many of these links are mediated through biochemical transformations of dietary, drug, or host compounds. This makes the microbiome a promising therapeutic target, especially as we could…

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