NIH R35 Grants — Outstanding Investigator Award

Recent R35 awards from NIH RePORTER

Examples of funded R35 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on September 5, 2026.

Example R35 projects from the sample

• Empowering NMR Utilization in Mechanistic Biology: Extending Size Limits and Catalyzing Automation

  3R35GM158220-02S1
  Haribabu Arthanari · DANA-FARBER CANCER INST, MA · $94,462 · awarded Aug 27, 2026 · NIH

  Abstract Nuclear Magnetic Resonance (NMR) has emerged as an essential tool for providing atomic-level insights into the structure, interactions, and dynamics of proteins, offering a unique perspective beyond what is achievable with de novo structure prediction programs, revealing domain orientations, alternate conformations, allosteric mechanisms, and minor…

• The Developmental Transition of Neural Stem Cell Niches in the Human Brain

  5R35NS143000-02
  Arturo Alvarez-Buylla · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA · $1,178,168 · awarded Aug 25, 2026 · NIH

  Project Summary Our earlier work identified the neural stem cells (NSC) and intermediate progenitors that generate new neurons and glial cells in the adult mouse brain. These NSCs are regionally specified to produce unique sets of inhibitory interneurons that migrate along the rostral migratory stream (RMS) to the olfactory bulb. Unlike rodents, the adult…

• Steroid hormone dependent gene expression and neuroplasticity in the brain.

  2R35GM142799-06
  Beau Alward · UNIVERSITY OF CALIFORNIA LOS ANGELES, CA · $421,922 · awarded Aug 25, 2026 · NIH

  PROJECT SUMMARY Steroid hormones in humans and other animals coordinate physiological and behavioral processes underlying optimal responses to the social environment. The brain is a major site of steroid hormone action, but our understanding of how steroid hormones regulate gene expression and neuroplasticity in the brain remains limited. My research…

• A path to personalized phenotypic prediction: unlocking the context-dependency of allelic effects

  7R35GM124881-09
  Julien Ayroles · UNIVERSITY OF CALIFORNIA BERKELEY, CA · $433,350 · awarded Aug 24, 2026 · NIH

  PROJECT SUMMARY Many of our most onerous health burdens today are driven by complex and poorly understood interactions between a person’s genetic makeup and his or her environment. In other words, genetic variation may predispose individuals toward physiological sensitivity or resilience in the face of environmental perturbations. Our modern environments…

• Hypertensive Toads: Investigating the Physiological and Evolutionary Pathways to Salt Tolerance in Amphibians

  5R35GM160308-02
  Molly Albecker · UNIVERSITY OF HOUSTON, TX · $431,750 · awarded Aug 21, 2026 · NIH

  PROJECT SUMMARY My lab focuses on understanding the evolutionary and physiological mechanisms that enable salt-sensitive freshwater organisms, such as anuran amphibians, to develop resilience in saline environments. Chronic exposure to elevated salt levels, whether from environment or diet, can cause detrimental health effects for frogs and humans alike, as…

• Causes and consequences of regulatory genetic variation

  3R35GM124676-10S1
  Frank Albert · UNIVERSITY OF MINNESOTA, MN · $52,315 · awarded Aug 21, 2026 · NIH

  Project Summary / Abstract Genetic variation among individuals shapes important phenotypes, including the risk for common human diseases. In particular, regulatory genetic variation causes inter-individual differences in gene expression. The resulting gene expression differences account for a substantial portion of variation in many genetically complex…

• Lipid functions in bacterial cell organization

  7R35GM147015-05
  Brittany Belin · UNIVERSITY OF KENTUCKY, KY · $385,000 · awarded Aug 20, 2026 · NIH

  Title: Lipid functions in bacterial membrane organization Project Abstract: Cellular membranes can be organized by the formation of discrete membrane microdomains (MMs), such as the cholesterol- and flotillin-rich “lipid rafts” found in eukaryotes. In bacteria, little is understood about the spatial organization of the cell membrane. Because this domain…

• Modeling the dynamics of disease elimination

  5R35GM147702-05
  Seth Blumberg · UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA · $403,750 · awarded Aug 18, 2026 · NIH

  Elimination of an infectious disease is often a goal of the public health community. Although that goal is rarely achieved, the tremendous expansion of epidemiological databases provides new opportunities to test hypotheses concerning elimination with mathematical modeling. Besides improving our scientific understanding of disease transmission, hypotheses…

• Elucidating the regulation and function of amyloid-like assemblies

  5R35GM124633-10
  Luke Berchowitz · COLUMBIA UNIVERSITY HEALTH SCIENCES, NY · $449,473 · awarded Aug 14, 2026 · NIH

  PROJECT SUMMARY Although amyloids are best understood for their roles in the etiology of numerous human diseases as pathological protein deposits, amyloid and amyloid-like assemblies can serve critical functions1. To mediate these functions, some cells have the ability to regulate assembly and clearance of these structures2,3. My research vision is to…

• Observational causal inference with infectious disease outcomes

  5R35GM155224-03
  Alyssa Bilinski · BROWN UNIVERSITY, RI · $382,851 · awarded Aug 13, 2026 · NIH

  Project Summary Infectious disease is a leading cause of global morbidity and mortality. Transmission dynamic models have played a critical role in guiding interventions related to many infectious pathogens, including HIV, influenza, SARS-CoV-1, ebolaviruses, SARS-CoV-2, and mpox. Models project how potential interventions (e.g., non- pharmaceutical…

• Mechanisms that Couple Chromatin Modifications to Transcription

  2R35GM141964-06
  KAREN ARNDT · UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA · $463,937 · awarded Aug 12, 2026 · NIH

  PROJECT SUMMARY The goal of this research program is to provide new understanding of the proteins and mechanisms that control transcription within the chromatin environment of eukaryotic cells. For RNA synthesis to proceed efficiently and accurately, RNA polymerase II (Pol II) must overcome the repressive effects of nucleosomes, which impede its movement…

• MULTI-RESOLUTION COMPUTATIONAL PROBES OF BIOMOLECULAR STRUCTURE AND FUNCTION

  1R35GM164118-01
  Aleksei Aksimentiev · UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, IL · $2,101,232 · awarded Aug 7, 2026 · NIH

  PROJECT SUMMARY / ABSTRACT Knowing exactly how biological processes arises from a collection of small unanimated molecules is one of the grand questions of modern science. This question, however, is not just a mere curiosity, not a trending topic, and not an intellectual Everest. Answering this question is necessary to understand disease and improve health.…

Compare nearby NIH grant mechanisms

Searchers often land on R35 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.

Open NIH NOFOs for R35

NIH accepts R35 applications only through a notice of funding opportunity (NOFO). These 4 are open or opening soon; each page lists due dates, participating institutes, related notices, and the projects NIH funded under it.