NIH Grant Search by PI — Funded Principal Investigator Finder

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Found 168 principal investigators from 200 displayed projects for "R35" (2021–2026)

Note: 1,463 projects matched but only the first 200 were analyzed. Try narrowing your search with a more specific term or selecting "Project title only".

Opportunity Digest

Heuristic scoring to help trainees and job seekers prioritize which labs to inspect first.

38

High-opportunity leads

167

Likely hiring signals

0

Training-friendly awards

60

Average opportunity score

Prioritize records with strong opportunity signals, then validate fit using abstracts, institution pages, and lab websites.

Filter for opportunity type

Matthew D Disney

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,387,500
FY 2026

Project Title

Design of Precision Small Molecules Targeting RNA Repeating Transcripts to Manipulate and Study Disease Biology

Grant Number:

5R35NS116846-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

4/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: An extraordinarily challenging problem is to develop general methods to target defective or malfunctioning RNAs that cause disease selectively. Current therapeutic strategies to target RNAs are based on specific sequence recognition by oligonucleotides. However, many human disorders...

Research Terms

<Affect><Alleles><Allelomorphs><Amentia><Award><Base Pairing><Biology><Body Tissues><CRISPR><CRISPR/Cas system><Chemicals><Clustered Regularly Interspaced Short Palindromic Repeats><Code><Coding System><Defect><Dementia><Disease><Disorder><Drug Synthesis and Chemistry><Drugs><Engineering><Ensure><Escalante syndrome><Foundations><Fragile X><Fragile X Syndrome><Funding><Gene Inactivation><Gene Silencing><Genes><Genetic Polymorphism><Health><Human><In Situ><Intervening Sequences><Introns><Investments><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Mediating><Medication><Methods><Microsatellite Markers><Microsatellite Repeats><Microsatellites><Modality><Modern Man><Neuromuscular Diseases><Non-Polyadenylated RNA><ORFs><Oligo><Oligonucleotides><Open Reading Frames><Pathology><Pathway interactions><Patients><Pharmaceutical Preparations><Protein Coding Region><RNA><RNA Decay><RNA Gene Products><Renpenning syndrome 2><Research><Ribonucleic Acid><Site><Structure><Therapeutic><Tissues><Toxin><Transcript><UTRs><Untranslated Regions><Work><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><autism-fragile X (AFRAX) syndrome><design><designing><drug action><drug synthesis><drug/agent><flexibility><flexible><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><human disease><in vivo><innovate><innovation><innovative><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><molecular recognition><myoneural disorder><neuromuscular degenerative disorder><neuromuscular disorder><novel><nuclease><oligos><pathway><polymorphism><pre-clinical development><preclinical development><programs><recruit><small molecule><tool><transcriptional silencing>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

VAIA LIDA CHATZI

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,256,897
FY 2026

Project Title

Translational Research Program on PFAS and Metabolic Diseases: A Solution Oriented Framework

Grant Number:

1R35ES035051-01A1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/10/2026

End Date:

3/31/2034

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT This R35 application aims to revolutionize precision environmental health in a model research program addressing the complex health risks posed by per- and polyfluoroalkyl substances (PFAS), with a focus on metabolic diseases such as obesity, type 2 diabetes, and metabolic-associated steato...

Research Terms

<3-D><3-Dimensional><3D><Address><Adult-Onset Diabetes Mellitus><Affect><Area><Biological><Biological Markers><Blood><Blood Reticuloendothelial System><Chemicals><Chronic Disease><Chronic Illness><Communities><Complex><Data><Data Science><Data Set><Early identification><Ensure><Environmental Exposure><Environmental Health><Environmental Health Science><Environmental Pollutants><Epidemiological data><Epidemiology data><Exposure to><Health><Hepatic Disorder><Human><In Vitro><Intermediary Metabolism><Intervention><Intervention Strategies><Ketosis-Resistant Diabetes Mellitus><Knowledge><Leadership><Link><Liver><Liver diseases><Maturity-Onset Diabetes Mellitus><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolism><Modeling><Modern Man><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Obesity><Outcome><PFAS><Participant><Pathway interactions><Poly-fluoroalkyl substances><Preventative strategy><Prevention strategy><Preventive strategy><Research><Risk><Risk Assessment><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><T2 DM><T2D><T2DM><Techniques><Thesaurismosis><Translating><Translational Research Enterprise><Translations><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><adiposity><adult onset diabetes><bio-markers><biologic><biologic marker><biomarker><chronic disorder><cohort><community engagement><community intervention><community level intervention><community-based intervention><corpulence><data integration><disease risk><disorder risk><engagement with communities><environmental contaminant><epidemiologic data><epidemiologic discoveries><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><flexibility><flexible><hepatic body system><hepatic disease><hepatic organ system><hepatopathy><in vitro Model><innovate><innovation><innovative><ketosis resistant diabetes><life span><lifespan><liver disorder><maturity onset diabetes><metabolism disorder><multiomics><multiple omics><panomics><pathway><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><polyfluorinated alkyl substances><polyfluoroalkyl substances><programs><public health priorities><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><three dimensional><tissue culture><tool><translation><translation research enterprise><translational model><translational research program><type 2 DM><type II DM><type two diabetes>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

ROBERT B DARNELL

ROCKEFELLER UNIVERSITY, NEW YORK, NY

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,208,576
FY 2026

Project Title

Applying RNA Logic in Space and Time to Neurologic Disease

Grant Number:

5R35NS143059-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

4/30/2033

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

2024 R35 Project Summary This proposal presents a series of interrelated new techniques and concepts aimed at discovering otherwise hidden therapeutic targets for neurologic diseases. This treatment-oriented approach combines the urgency of a practicing neurologist with the knowledge and technology ...

Research Terms

<Address><Affect><Autopsy><Basic Research><Basic Science><Big Data><BigData><Biologic Models><Biological><Biological Models><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Causality><Cell Body><Cells><Complex><Computational Biology><DNA><DNA Molecular Biology><Data><Data Analyses><Data Analysis><Data Set><Defect><Deoxyribonucleic Acid><Development><Disease><Disorder><Encephalon><Encephalon Diseases><Etiology><Genetic><Goals><Human><Individual><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Knowledge><Logic><Maps><Mediating><Methods><Model System><Modern Man><Modernization><Molecular><Molecular Biology><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurobiology><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurologist><Neurons><Neurosciences><Non-Polyadenylated RNA><Proteins><RNA><RNA Gene Products><RNA Seq><RNA analysis><RNA sequencing><RNAseq><Regulation><Ribonucleic Acid><Series><System><Techniques><Technology><Time><Variant><Variation><Work><biologic><causation><cell type><computer biology><data integration><data interpretation><developmental><disease causation><human disease><innovate><innovation><innovative><insight><large data sets><large datasets><necropsy><neurobiological><neurological disease><neuronal><novel><postmortem><stoichiometry><success><therapeutic target><tool development><transcriptome sequencing><transcriptomic sequencing><validation studies>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

DIMITRI KRAINC

NORTHWESTERN UNIVERSITY, CHICAGO, IL

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,200,000
FY 2026

Project Title

Mechanistic Analysis of Genetic Modifiers in Parkinson's Disease

Grant Number:

5R35NS122257-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2021

End Date:

4/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary I believe that combining disease gene discovery approaches with in-depth follow-up mechanistic and functional studies is a unique aspect of my research program. Our recent discovery of “human-specific” pathways and phenotypes (compared to mice) in midbrain DA neurons has led us to focus on ...

Research Terms

<Active Follow-up><Astrocytes><Astrocytus><Astroglia><Award><Biology><Cell Body><Cells><Co-culture><Cocultivation><Coculture><Coculture Techniques><DA Neuron><Disease><Disorder><Dopamine neuron><Dysfunction><Freedom><Functional disorder><Gene variant><Genes><Genetic><Glia><Glial Cells><Hortega cell><Human><Kolliker's reticulum><Liberty><Link><Lysosomes><Mesencephalon><Mice><Mice Mammals><Microglia><Mid-brain><Midbrain><Midbrain structure><Mitochondria><Modern Man><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neuron Degeneration><Neurons><Non-neuronal cell><Nonneuronal cell><Paralysis Agitans><Parkinson><Parkinson Disease><Pathway interactions><Patients><Phenotype><Physiopathology><Primary Parkinsonism><Research><Time><active followup><allelic variant><astrocytic glia><discover genes><dopaminergic neuron><follow up><follow-up><followed up><followup><gene discovery><genetic analysis><genetic variant><genomic variant><gitter cell><iPS><iPSC><iPSCs><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovative technologies><mesoglia><microglial cell><microgliocyte><mitochondrial><nerve cement><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal><neuronal degeneration><novel><pathophysiology><pathway><perivascular glial cell><programs>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Raghu VEMUGANTI

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,166,216
FY 2026

Project Title

Role of RNAs in post-stroke brain damage

Grant Number:

5R35NS132184-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

4/30/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Cerebral ischemia significantly alters the expression and/or function of transcriptional and translational mechanisms including various classes of noncoding RNAs, epigenetics and epitranscriptomics. My research in the past 20 years evaluated these mechanisms that are central in promoting either seco...

Research Terms

<Acquired brain injury><Adenosine><Apoplexy><Apoptotic><Binding><Brain><Brain Injuries><Brain Nervous System><Brain Vascular Accident><Cerebral Ischemia><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chemicals><Code><Coding System><Collaborations><DNA><Deoxyribonucleic Acid><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><Functional RNA><Funding><Future><Gene Transcription><Genes><Genetic Transcription><Goals><Grant><Inflammation><Inflammatory><Ischemia><Ischemic Brain Injury><Mediating><Messenger RNA><Methylation><MicroRNAs><Modification><Molecular><Molecular Interaction><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Pathologic><Position><Positioning Attribute><Post-Transcriptional Control><Post-Transcriptional Regulation><RNA><RNA Expression><RNA Gene Products><RNA methylation><RNA-Binding Proteins><Receptor Protein><Recovery><Recovery of Function><Research><Ribonucleic Acid><Role><Stroke><Transcription><Untranslated RNA><after stroke><brain attack><brain damage><brain-injured><cerebral vascular accident><cerebrovascular accident><circular RNA><closed circular RNA><demethylation><design><designing><epigenetically><epitranscriptomics><functional outcomes><functional recovery><glycation><ischemic brain damage><mRNA><miRNA><neural><neuroprotection><neuroprotective><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><non-enzymatic glycosylation><noncoding><nonenzymatic glycosylation><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><post stroke><post-transcriptional gene regulation><poststroke><receptor><sialic acid binding Ig-like lectin><siglec><social role><stroked><strokes><synuclein><therapeutic agent development><therapeutic development><tool>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Carolyn Calfee

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,124,681
FY 2026

Project Title

Advancing Precision Medicine for ARDS and Sepsis

Grant Number:

5R35HL177135-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract: The acute respiratory distress syndrome (ARDS) and sepsis are common causes of death in critically ill patients, yet both are clinical syndromes defined by non-specific signs and symptoms which encompass major clinical and biological heterogeneity. Pre-clinical studies have identified num...

Research Terms

<Address><Adrenal Cortex Hormones><Award><Biological><Cause of Death><Clinical><Clinical Data><Clinical Research><Clinical Study><Clinical Treatment><Clinical Trials><Collaborations><Corticoids><Corticosteroids><Critical Care><Critical Illness><Critically Ill><Data Bases><Databases><Diagnosis><Diagnostic Findings><Drug Therapy><Experimental Models><Fluid Therapy><Foundations><Functional Metagenomics><Goals><Hand><Heterogeneity><Hospital Mortality><Human><Immune response><In-house Mortalities><Infection><Inflammatory><Inhospital Mortality><Investigators><Life><Mechanical ventilation><Medicine><Metagenomics><Modeling><Modern Man><NHLBI><National Heart, Lung, and Blood Institute><Outcome><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pharmacological Treatment><Pharmacotherapy><Phenotype><Plasma Proteins><Position><Positioning Attribute><Prospective Studies><Recovery><Research><Research Personnel><Researchers><Sampling><Sepsis and ARDS><Signs and Symptoms><Simvastatin><Supportive Therapy><Supportive care><Syndrome><Synvinolin><Therapeutic Agents><Time><Translational Research><Translational Science><activated Protein C><acute respiratory distress syndrome caused by sepsis><biologic><biological heterogeneity><body fluid balance therapy><clinical care><clinical heterogeneity><clinical intervention><clinical therapy><cohort><data base><data modeling><drug intervention><drug treatment><druggable target><effective therapy><effective treatment><experience><hands><high dimensional data><host response><immune system response><immunoresponse><improved><improved outcome><in silico><in vivo><innovate><innovation><innovative><mechanical respiratory assist><mechanically ventilated><model of data><model the data><modeling of the data><molecular phenotype><multidimensional data><multidimensional datasets><new approaches><novel><novel approaches><novel strategies><novel strategy><pathogen><pathway><patient oriented outcomes><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pre-clinical study><precision medicine><precision-based medicine><preclinical study><prospective research study><prospective survey><protein biomarkers><protein markers><response><response to therapy><response to treatment><sepsis ARDS><sepsis acute respiratory distress syndrome><sepsis and acute respiratory distress syndrome><sepsis associated acute respiratory distress syndrome><sepsis induced ARDS><sepsis induced acute respiratory distress syndrome><sepsis related acute respiratory distress syndrome><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic response><therapy response><trait><translation research><translational investigation><treatment effect><treatment response><treatment responsiveness><trial regimen><trial treatment>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Giovanni Manfredi

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,101,750
FY 2026

Project Title

Mitochondrial Integrated Stress Response in Neurological Diseases

Grant Number:

5R35NS122209-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2021

End Date:

4/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Mitochondria play essential roles in cell biology because are central hubs of most metabolic pathways. They are not only essential for energy conversion, but also for the biosynthesis and catabolism of virtually all cell constituents. Mitochondrial dysfunction causes havoc in all cells, but especial...

Research Terms

<AD dementia><Address><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Anabolism><Body Tissues><Brain><Brain Nervous System><CNS Diseases><CNS disorder><Catabolism><Cell Body><Cells><Cellular Metabolic Process><Cellular Stress><Cellular Stress Response><Cellular biology><Central Nervous System Diseases><Central Nervous System Disorders><Cessation of life><Characteristics><DNA Alteration><DNA Sequence Alteration><Death><Defect><Development><Disease><Disorder><Encephalon><Encephalopathies><Event><Failure><Gene Transcription><Generations><Genetic><Genetic Alteration><Genetic Transcription><Glia><Glial Cells><Heart><Hereditary><Human><Inherited><Intermediary Metabolism><Knowledge><Kolliker's reticulum><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Mission><Mitochondria><Mitochondrial Diseases><Mitochondrial Disorders><Modern Man><Muscle><Muscle Tissue><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic Disorders><Neurological Disorders><Neuron Degeneration><Neurons><Non-neuronal cell><Nonneuronal cell><Nuclear><Organelles><Paralysis Agitans><Parkinson><Parkinson Disease><Pathogenesis><Pathogenicity><Pathologic><Peripheral><Play><Primary Parkinsonism><Primary Senile Degenerative Dementia><Proteins><Proteome><RNA Expression><Research><Role><Sequence Alteration><Series><Signal Pathway><Stress><Therapeutic><Tissues><Transcription><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age related neurodegeneration><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><aging associated neurodegeneration><aging associated neurodegenerative disease><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><biological adaptation to stress><biosynthesis><cell biology><cell metabolism><cell stress><cell type><cellular metabaolism><developmental><disease model><disorder model><effective therapy><effective treatment><genomic alteration><human disease><improved><innovative technologies><mitochondrial><mitochondrial dysfunction><mitochondrial genome><muscular><nerve cement><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neurological disease><neuronal><neuronal degeneration><premature><prematurity><primary degenerative dementia><reactioncrisis><response><senile dementia of the Alzheimer type><social role><stress response><stressreaction><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><virtual>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Henry L Paulson

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,087,708
FY 2026

Project Title

Mechanisms of neurodegenerative diseases: intersections with ubiquitin pathways

Grant Number:

5R35NS122302-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2021

End Date:

4/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This R35 proposal builds on the principal investigator’s longstanding success seeking the causes of age- related neurodegenerative diseases and developing treatments for these devastating and largely fatal disorders. The proposal’s unifying theme is a focus on proteins that participate in ubiquitin-...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><APF-1><ATP-Dependent Proteolysis Factor 1><Autoregulation><Biological><Brain><Brain Nervous System><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Complex><Degenerative Neurologic Disorders><Disease><Disorder><Elements><Encephalon><Environment><HMG-20><High Mobility Protein 20><Homeostasis><Impairment><Induced DNA Alteration><Induced Mutation><Induced Sequence Alteration><Intracellular Communication and Signaling><Knowledge><Link><Macropain><Macroxyproteinase><Mediating><Modeling><Multicatalytic Proteinase><Nerve Degeneration><Nervous System><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Body System><Neurologic Degenerative Conditions><Neurologic Disorders><Neurologic Organ System><Neurological Disorders><Neuron Degeneration><Nucleus><Pathogenesis><Pathogenicity><Pathway interactions><Phase><Phase Transition><Physiological Homeostasis><Poly Q><Principal Investigator><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteosome><Quality Control><Research><Role><Signal Transduction><Signal Transduction Systems><Signaling><System><Toxic effect><Toxicities><Ubiquitin><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age related neurodegeneration><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><aging associated neurodegeneration><aging associated neurodegenerative disease><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><biologic><biological signal transduction><cell type><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><develop therapy><innovate><innovation><innovative><intervention development><multicatalytic endopeptidase complex><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neurological disease><neuronal degeneration><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><polyQ><polyglutamine><response><social role><success><therapeutic target><therapy development><tool><treatment development><ubiquilin>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

RONALD TJALKENS

COLORADO STATE UNIVERSITY, FORT COLLINS, CO

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,073,597
FY 2026

Project Title

Deciphering innate immune signaling mechanisms in glial cells linking lifetime environmental exposures to neuroinflammation, protein aggregation and neurodegeneration in Parkinsons disease

Grant Number:

5R35ES035043-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/12/2023

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Parkinson’s disease (PD) is a debilitating movement disorder affecting the central nervous system (CNS) and is the second most common neurodegenerative disease worldwide after Alzheimer’s disease (AD). In addition to age and genetic background, environmental exposures are strongly as...

Research Terms

<AD dementia><Address><Affect><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Bacteria><Brain><Brain Nervous System><CNS Nervous System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Complex><Degenerative Neurologic Disorders><Development><Disease><Disorder><Dyskinesia Syndromes><Encephalon><Environmental Exposure><Environmental Toxin><Event><Exposure to><Generations><Genetic><Glia><Glial Cells><Goals><Heavy Metals><Human Resources><Image><Immune signaling><Infectious Agent><Inflammatory><Inflammatory Response><Informatics><Innate Immune Response><Intracellular Communication and Signaling><Kolliker's reticulum><Link><Longitudinal Studies><Longitudinal Surveys><Manpower><Molecular><Molecular Fingerprinting><Molecular Profiling><Movement Disorder Syndromes><Movement Disorders><Multiple types of exposure><Nerve Degeneration><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Network-based><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neuroimmune><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Development Disorder><Neurological Disorders><Neuron Degeneration><Neurotoxins><Non-neuronal cell><Nonneuronal cell><Paralysis Agitans><Parkinson><Parkinson Disease><Pathway interactions><Pesticides><Phase><Phenotype><Population><Primary Parkinsonism><Primary Senile Degenerative Dementia><Regulation><Research Resources><Resources><Risk><Risk Factors><Signal Transduction><Signal Transduction Systems><Signaling><Toxic Environmental Agents><Toxic Environmental Substances><Toxicant exposure><Transgenic Model><Viral Diseases><Virus><Virus Diseases><ages><biological signal transduction><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><environmental toxicant><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><glial activation><glial cell activation><imaging><infectious organism><insoluble aggregate><life span><lifespan><long-term study><longitudinal outcome studies><longitudinal research study><molecular profile><molecular signature><multi-exposure><multiple exposures><multitude of exposure><nerve cement><neural degeneration><neural inflammation><neural network><neurodegeneration><neurodegenerative><neurodegenerative illness><neurodevelopmental disease><neuroinflammation><neuroinflammatory><neurological degeneration><neurological disease><neuronal degeneration><neurotoxic><neurotoxicant><pathogen><pathway><personnel><primary degenerative dementia><protein aggregate><protein aggregation><senile dementia of the Alzheimer type><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><tool><toxic exposure><transgenic trait><various exposures><various types of exposure><viral infection><virus infection><virus-induced disease>
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Matthew S. Gentry

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,055,382
FY 2026

Project Title

Brain Glycogen-Metabolism,Mechanisms, and Therapeutic Potential

Grant Number:

5R35NS116824-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2020

End Date:

4/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Brain metabolism is a fundamental aspect of biology and human disease. The brain critically depends on glucose, consuming large quantities as the biochemical fuel for cognition, memory, and behavior. Fundamental aspects of brain metabolism have been extensively studied, but recent evidence regarding...

Research Terms

<12-20 years old><AD dementia><Abscission><Adolescence><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Ataxia><Ataxy><Autoregulation><Behavior><Biochemical><Biology><Body Tissues><Brain><Brain Nervous System><Carbohydrates><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cellular Function><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Cessation of life><Cognition><Complex><Comprehension><Consumption><Coordination Impairment><D-Glucan><D-Glucose><DNA mutation><Data><Death><Development><Dextrose><Diagnosis><Disease><Disease Progression><Disorder><Dyssynergia><Encephalon><Epilepsy, Progressive Myoclonic, Lafora><Event><Excision><Extirpation><Freedom><Funding><Genetic Change><Genetic defect><Genetic mutation><Glucose><Glycogen><Glycogen Storage Disease><Glycogenosis><Homeostasis><Intermediary Metabolism><Intracellular Communication and Signaling><Intractable Epilepsy><Knowledge><Lafora Body Disease><Lafora Disease><Lafora Type Progressive Myoclonic Epilepsy><Liberty><Memory><Metabolic><Metabolic Processes><Metabolism><Modality><Modeling><Molecular><Mutation><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nerve Degeneration><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Neuron Degeneration><Patients><Physiological Homeostasis><Play><Primary Senile Degenerative Dementia><Refractory epilepsy><Removal><Research><Role><Seminal><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Surgical Removal><Symptoms><Therapeutic><Tissues><Translating><Vegetative States><Work><adolescence (12-20)><autosome><biological signal transduction><biomarker development><brain metabolism><cell metabolism><cellular metabaolism><develop therapy><developmental><driving force><drug-resistant epilepsy><flexibility><flexible><genome mutation><glucose metabolism><glycogen metabolism><human disease><insight><intervention development><mouse model><murine model><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neurological disease><neuronal degeneration><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><polyglucosan><pre-clinical><preclinical><primary degenerative dementia><resection><senile dementia of the Alzheimer type><sex><social role><therapy development><tool><treatment development>
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JOSEPH E ITALIANO

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,040,760
FY 2026

Project Title

The Centrosome as a master controller of platelet production.

Grant Number:

5R35HL161175-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Platelets are specialized anucleate cells that play an essential role in hemostasis, angiogenesis, immunity, and inflammation. Thrombocytopenia (platelet counts <150x109/L) is a major clinical problem encountered across a number of conditions including immune (idiopathic) thrombocytopenic purpura, m...

Research Terms

<Acceleration><Actins><Alpha Granule><Biogenesis><Biology><Biomedical Engineering><Blood><Blood Platelet Count><Blood Platelet Number><Blood Platelets><Blood Reticuloendothelial System><Blood Vessels><Blood megakaryocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><Cell Body><Cells><Cellular Matrix><Centrosome><Clinical><Clotting><Coagulation><Coagulation Process><Cytoplasm><Cytoskeletal System><Cytoskeleton><Data><Deposit><Deposition><Dose><Drugs><Dysmyelopoietic Syndromes><Endothelium><Genetic Diseases><Hemostasis><Hemostatic function><Image Analyses><Image Analysis><Immune><Immunes><Immunity><Inflammation><Infusion><Infusion procedures><Investigation><Isomerase><Isomerase Gene><Knowledge><Laboratories><Leadership><Life><Marrow platelet><Mechanics><Medication><Megakaryocytes><Megalokaryocyte><Mentorship><Mercaptans><Mercapto Compounds><Micro-tubule><Microfluidics><Microscopy><Microtubules><Molecular Target><Motor><Myelodysplastic Disease><Myelodysplastic Syndromes><Network Analysis><Operative Procedures><Operative Surgical Procedures><Organelles><Origin of Life><Pathway Analysis><Patients><Penetration><Pharmaceutical Preparations><Physiologic><Physiological><Platelet Count><Platelet Count measurement><Platelet Granule><Platelet Number><Platelets><Play><Process><Production><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Regulation><Role><Scientist><Signal Pathway><Smoldering Leukemia><Structure><Sulfhydryl Compounds><Surgical><Surgical Interventions><Surgical Procedure><Testing><Therapeutic><Thiols><Thrombocytes><Thrombocytopenia><Thrombocytopenic Purpura><Thrombopenia><Thrombopenic Purpura><Time><angiogenesis><base><bases><bio-engineered><bio-engineers><bioengineering><biological engineering><chemotherapy><chip model><chip system><drug/agent><experience><genetic condition><genetic disorder><image evaluation><image interpretation><improved><infusions><injury to the vasculature><intracellular skeleton><mechanic><mechanical><myelodysplasia><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><on a chip><on chip><precursor cell><programs><repair><repaired><response><small molecule><social role><sulfhydryl group><surgery><theories><vascular><vascular injury><µfluidic><α-Granule>
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Eric D Lazartigues

LSU HEALTH SCIENCES CENTER, NEW ORLEANS, LA

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,008,719
FY 2026

Project Title

Screening and validation of miRNA targets for neurogenic hypertension.

Grant Number:

1R35HL184169-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/6/2026

End Date:

3/31/2033

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Program Summary With prevalence as high as 55% in individuals aged 55 and older in the United States, hypertension (HTN) is a major risk factor contributing to cardiovascular diseases and global mortality, hence remaining an increasingly important medical and public health issue. Despite the abundan...

Research Terms

<ACE2><Affect><AngII><Angiotensin II><Angiotensins><Anti-Hypertensive Agents><Anti-Hypertensive Drugs><Anti-Hypertensives><BP homeostasis><BP regulation><Blood Pressure><Brain><Brain Nervous System><CNS Nervous System><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cell Nucleus><Central Nervous System><Development><Disease><Disorder><Dysfunction><E3 Ligase><E3 Ubiquitin Ligase><E3 ubiquitin-protein ligase NEDD4-like><Encephalon><Enzyme Gene><Enzymes><Experimental Models><Failure><Functional RNA><Functional disorder><Funding><Generations><Goals><Heart Vascular><Heart failure><Hypertension><Hypotensive Agent><Hypotensive Drugs><Hypothalamic structure><Hypothalamus><Impairment><In Vitro><Individual><Laboratories><Maintenance><Maps><Medical><Mice><Mice Mammals><MicroRNAs><Murine><Mus><Nedd4-2><Nedd4L><Nerve Cells><Nerve Unit><Neural Cell><Neural precursor cell expressed developmentally down-regulated gene 4-like><Neuraxis><Neurocyte><Neurons><Noncoding RNA><Nontranslated RNA><Nucleus><Paraventricular Hypothalamic Nucleus><Patients><Physiopathology><Population><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Prevalence><Protein Modification><Public Health><Renin-Angiotensin System><Resistant Hypertension><Risk Factors><Role><Sampling><Scientist><Specificity><System><Therapeutic><Training><Ubiquitilation><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><United States><Untranslated RNA><Validation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><aged><angiotensin converting enzyme 2><angiotensin converting enzyme II><anti-hypertension><blood pressure homeostasis><blood pressure medication><blood pressure medicine><blood pressure regulation><cardiac failure><cardiovascular disorder><circulatory system><clinical relevance><clinically relevant><developmental><differential expression><differentially expressed><flexibility><flexible><high blood pressure><hyperpiesia><hyperpiesis><hypertensive><hypertensive disease><hypertensive disorder><hypothalamic><in vivo><interest><loss of function><miRNA><mortality><neurogenic hypertension><neuronal><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><noncoding><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><paraventricular nucleus><pathophysiology><prevent><preventing><programs><regulate BP><regulate blood pressure><screening><screenings><sex><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><therapeutic target><transcriptional differences><translational impact><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase><validations>
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J Edwin Blalock

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,005,543
FY 2026

Project Title

Pathogenic Exosomes in COPD

Grant Number:

5R35HL166433-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The thesis of this R35 Program is that immune cell derived “pathogenic exosomes” are key players in chronic obstructive pulmonary disease (COPD) and that their role can be modeled in a smoking mouse model of exosome transfer to attain novel understanding of the disease which can in ...

Research Terms

<A1PI><African American><Afro American><Afroamerican><Animal Model><Animal Models and Related Studies><Animals><Antiproteases><Asian><Biochemistry><Biological Chemistry><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Body Tissues><COPD><Cardiology><Caucasian><Caucasian Race><Caucasians><Caucasoid><Caucasoid Race><Cell Body><Cell Death><Cell-Extracellular Matrix><Cells><Cellular biology><Chemistry><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><DNA Molecular Biology><Disease><Disorder><ECM><Endopeptidase Inhibitors><Esteroproteases><Extracellular Matrix><Extracellular Matrix Degradation><Faculty><Goals><Grant><Granulocyte Elastase><Human><Human Biology><Immune><Immunes><Inflammation><Latina><Leukocyte Elastase><Lysosomal Elastase><MD students><Marrow Neutrophil><Medical Students><Mentors><Mice><Mice Mammals><Mission><Modeling><Modern Man><Molecular Biology><Murine><Mus><NHLBI><NIH><National Heart, Lung, and Blood Institute><National Institutes of Health><Neutrophil Elastase><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Occidental><PMN Elastase><Pathogenicity><Pathway interactions><Patients><Peptidase Inhibitors><Peptidases><Peptide Hydrolase Inhibitors><Peptide Hydrolases><Peptide Peptidohydrolase Inhibitors><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Phase><Phenotype><Physicians><Physiology><Polymorphonuclear Cell><Polymorphonuclear Leukocyte Elastase><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Postdoc><Postdoctoral Fellow><Protease Antagonists><Protease Gene><Protease Inhibitor><Proteases><Protein Kinase Interaction><Proteinase Inhibitors><Proteinases><Proteolytic Enzymes><Receptor-Interacting Protein><Research><Research Associate><Research Resources><Resistance><Resources><Role><Scientist><Smoker><Smoking><Strategic vision><Surface><Tissues><Training><Translating><United States National Institutes of Health><Work><alpha 1 Antiprotease><alpha 1-Antiproteinase><alpha 1-Antitrypsin><alpha 1-Antitrypsin Trypsin Inhibitor><alpha 1-Protease Inhibitor><alpha 1-Proteinase Inhibitor><cell biology><chronic inflammatory disease><chronic obstructive pulmonary disorder><cigarette smoke exposure><cigarette smoke-induced><disease phenotype><doctoral student><exosome><exposure to cigarette smoke><extracellular><extracellular vesicles><human disease><innovate><innovation><innovative><medical school students><member><model of animal><mouse model><multidisciplinary><murine model><necrocytosis><neutrophil><new diagnostics><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation diagnostics><next generation therapeutics><novel><novel diagnostics><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><pathogen><pathway><post-doc><post-doctoral><post-doctoral trainee><programs><pulmonary><research associates><resistant><social role><therapeutic agent development><therapeutic development><white race><α1-Antitrypsin><α1-Proteinase Inhibitor>
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Baljit Khakh

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,000,412
FY 2026

Project Title

Fundamental astrocyte biology in intact neural circuits

Grant Number:

5R35NS111583-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2019

End Date:

4/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

A central goal of neurobiology is to understand how the brain forms, stores, retrieves, modifies and encodes information, and to determine how these operations go awry in neurological and psychiatric diseases. The focus of this application is astrocytes, a type of glia. Long considered simply the br...

Research Terms

<21+ years old><Abscission><Acquired brain injury><Adult><Adult Human><Astrocytes><Astrocytus><Astroglia><Autoregulation><Award><Basal Ganglia><Basal Nuclei><Biology><Blood Vessels><Brain><Brain Diseases><Brain Disorders><Brain Injuries><Brain Nervous System><CNS Nervous System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Corpus Striatum><Corpus striatum structure><Data><Data Bases><Databases><Development><Disease><Disorder><Dysfunction><Encephalon><Encephalon Diseases><Environment><Evaluation><Excision><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Extirpation><Functional disorder><Glia><Glial Cells><Glues><Goals><Homeostasis><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Ions><Kolliker's reticulum><Laboratories><Maintenance><Mental disorders><Mental health disorders><Molecular><Nerve Cells><Nerve Transmitter Substances><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Transmission><Neuraxis><Neurobiology><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic Disorders><Neurological Disorders><Neurons><Neurosciences><Neurotransmitters><Non-neuronal cell><Nonneuronal cell><Physicians><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Process><Psychiatric Disease><Psychiatric Disorder><R21 Award><Regulation><Removal><Research><Research Resources><Resources><Role><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Striate Body><Striatum><Surgical Removal><Synapses><Synaptic><Synaptic Transmission><Testing><Therapeutic><Training><Withdrawal><Work><adulthood><astrocytic glia><biological signal transduction><brain damage><brain-injured><data base><developmental><excitotoxic><excitotoxicity><in vivo><insight><mental illness><nerve cement><neural><neural circuit><neural circuitry><neuro-vascular coupling><neurobiological><neurocircuitry><neurological disease><neuronal><neurovascular coupling><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><operation><operations><pathophysiology><programs><psychiatric illness><psychological disorder><resection><social role><striatal><synapse><synapse formation><synaptic circuit><synaptic circuitry><synaptogenesis><tool><vascular>
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Shahin Rafii

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$997,417
FY 2026

Project Title

Adaptable tissue-specific endothelial cells for organ regeneration

Grant Number:

5R35HL150809-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2020

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT ABSTRACT The overarching goal of our proposed research program is to develop a discovery pipeline that will enable identification of transcriptional codes for engineering tissue-specific endothelial cells (ECs) for therapeutic organ regeneration of heart, lung and blood. Therapies for organ ...

Research Terms

<21+ years old><Active Follow-up><Adult><Adult Human><Allogenic><Autoregulation><Award><Blood><Blood Reticuloendothelial System><Blood Vessels><Body Tissues><Cardiac><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cells><Cicatrix><Clinic><Clinical Trials><Co-culture><Cocultivation><Coculture><Coculture Techniques><Code><Coding System><Dysfunction><Endothelial Cells><Engineering><FDA approved><Fibrosis><Functional disorder><Gene Transcription><Genetic Transcription><Goals><Growth Agents><Growth Factor><Growth Substances><Heart><Hematopoietic><Hepatic><Heterogeneity><Homeostasis><Human><In Vitro><Infusion><Infusion procedures><Intention><Intracellular Communication and Signaling><Lung><Lung Respiratory System><M nemestrina><M. nemestrina><Macaca nemestrina><Mice><Mice Mammals><Mission><Modern Man><Molecular><Monkeys><Morphogenesis><Murine><Mus><NHLBI><National Heart, Lung, and Blood Institute><Natural regeneration><Non-Polyadenylated RNA><Oncogenesis><Organ><Organ healing><Organoids><Outcome><Pathway interactions><Physiological Homeostasis><Physiopathology><Pigtail Macaque><Pigtail Monkey><Production><Progenitor Cells><Proteins Growth Factors><RNA><RNA Expression><RNA Gene Products><Recovery><Regeneration><Regenerative Medicine><Research><Ribonucleic Acid><Safety><Scars><Signal Transduction><Signal Transduction Systems><Signaling><Specific qualifier value><Specified><Strains Cell Lines><Technology><Testing><Therapeutic><Tissue Engineering><Tissue Transplantation><Tissues><Transcription><Translating><Translations><Transplantation><active followup><adulthood><bioengineered tissue><biological signal transduction><cell transduction><cellular transduction><cultured cell line><efficacious therapy><efficacious treatment><engineered tissue><experiment><experimental research><experimental study><experiments><fetal><follow up><follow-up><followed up><followup><healing><hemopoietic><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><in vivo><induced human pluripotent stem cells><infusions><injury to organs><innovate><innovation><innovative><knock-down><knockdown><lung repair><lung tissue repair><morphogenetic process><non-human primate><nonhuman primate><novel><organ injury><organ regeneration><organ repair><overexpress><overexpression><pathophysiology><pathway><pig-tailed macaque><programs><pulmonary><pulmonary repair><reconstitute><reconstitution><regenerate><regenerative><repair><repaired><replacement tissue><stem cells><tissue repair><transduced cells><translation><transplant><tumorigenesis><vascular><vascular contributions>
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Stephen F Traynelis

EMORY UNIVERSITY, ATLANTA, GA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$992,303
FY 2026

Project Title

Glutamate receptors and human neurological disease

Grant Number:

5R35NS111619-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2019

End Date:

4/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This R35 Research Program proposal will use electrophysiological, molecular, and structural approaches to probe multiple aspects of excitatory synaptic function that are relevant for neurological disease. We will focus on the elucidation and modulation of the functional properties of postsynaptic gl...

Research Terms

<AD dementia><Address><Agonist><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Apoplexy><Binding><Binding Sites><Biology><Brain><Brain Nervous System><Brain Vascular Accident><Cations><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chemistry><Clinical><Collaborations><Combining Site><Corpus Striatum><Corpus striatum structure><Cryo-electron Microscopy><Cryoelectron Microscopy><Crystallographies><Crystallography><DNA mutation><Development><Disease><Disorder><Electron Cryomicroscopy><Electrophysiology><Electrophysiology (science)><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Evaluation><GRIN1><Gene Frequency><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Variation><Genetic defect><Genetic mutation><Genome><GluN1><Glutamate Receptor><Glutamates><Human><Individual><Ion Channel><Ionic Channels><Ischemia><L-Glutamate><Learning><Mediating><Medicinal Chemistry><Membrane Channels><Memory><Modern Man><Molecular><Molecular Interaction><Mutation><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><N-methyl-D-aspartate receptor subunit NR1><NMDA Receptor-Ionophore Complex><NMDA Receptors><NMDA receptor A1><NMDAR1><NMDARA1 protein><Nervous System Diseases><Nervous System Disorder><Neural Transmission><Neurologic><Neurologic Disorders><Neurological><Neurological Disorders><Neurophysiology / Electrophysiology><Neuroprotectants><Neuroprotective Agents><Neuroprotective Drugs><Orphan Disease><Paralysis Agitans><Parkinson><Parkinson Disease><Penetration><Permeability><Pharmaceutic Chemistry><Pharmaceutical Chemistry><Population><Primary Parkinsonism><Primary Senile Degenerative Dementia><Probability><Process><Property><Protein Region><Rare Diseases><Rare Disorder><Reactive Site><Receptor Protein><Receptor Signaling><Research><Risk Factors><Robotics><Role><Seizure Disorder><Site><Solubility><Striate Body><Striatum><Stroke><Structure><Synaptic Transmission><Thalamic structure><Thalamus><Therapeutic><Variant><Variation><allelic frequency><brain attack><cerebral vascular accident><cerebrovascular accident><cryo-EM><cryoEM><cryogenic electron microscopy><design><designing><developmental><disease risk><disorder risk><electrophysiological><epilepsia><epileptogenic><experiment><experimental research><experimental study><experiments><genetic analysis><genome mutation><glutamate receptor, ionotropic, N-methyl D-aspartate 1><glutamatergic><improved><in vivo><in vivo Model><insight><interest><low-frequency mutation><neurological disease><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><orphan disorder><pharmacologic><postsynaptic><precision medicine><precision-based medicine><primary degenerative dementia><programs><rare allele><rare mutation><rare variant><receptor><receptor function><senile dementia of the Alzheimer type><side effect><social role><striatal><stroked><strokes><structural biology><synapse function><synaptic function><thalamic><tool><treatment strategy>
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Patricia L Opresko

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$931,280
FY 2026

Project Title

Excision Repair of Environmental Telomere Damage

Grant Number:

5R35ES030396-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2019

End Date:

4/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary Numerous studies in human populations, human tissue, animal models and cell culture demonstrate that environmental genotoxic and oxidative stress are associated with accelerated telomere shortening and dysfunction. Telomeres at chromosome ends are essential for genome stability and sustained...

Research Terms

<Acceleration><Animal Model><Animal Models and Related Studies><Award><Brachydanio rerio><Cancer Induction><Cell Body><Cell Culture Techniques><Cell Function><Cell Growth in Number><Cell Multiplication><Cell Physiology><Cell Process><Cell Proliferation><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Proliferation><Chromosomes><Chronic><DNA Damage><DNA Injury><DNA lesion><Danio rerio><Degenerative Disorder><Dysfunction><Environment><Excision Repair><Functional disorder><Funding><Generations><Genetic><Genome Stability><Genomic Stability><Genotoxic Stress><Goals><Guanine><Health><Human><Knowledge><Learning><Lesion><Maintenance><Malignant Cell><Measures><Mice><Mice Mammals><Modern Man><Murine><Mus><NIEHS><National Institute of Environmental Health Sciences><Organ><Organism><Outcome><Oxidative Stress><Pathway interactions><Phase><Phenotype><Physiopathology><Population><Proliferating><Proteins><Research><Subcellular Process><System><Technology><Telomere Maintenance><Telomere Shortening><Transgenic Organisms><Translating><Work><Zebra Danio><Zebra Fish><Zebrafish><base><bases><cancer cell><cancer prevention><carcinogenesis><cell culture><cell cultures><cell type><degenerative condition><degenerative disease><experiment><experimental research><experimental study><experiments><flexibility><flexible><human tissue><innovate><innovation><innovative><living system><model of animal><model organism><nucleobase><pathophysiology><pathway><preservation><programs><repair><repaired><telomere><telomere attrition><telomere damage><telomere loss><telomeric damage><telomeric loss><tool><transgenic>
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ROBERT G GOURDIE

VIRGINIA POLYTECHNIC INST AND ST UNIV, BLACKSBURG, VA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$927,818
FY 2026

Project Title

Connexin-based Signaling in the Heart: Cellular and Exosomal

Grant Number:

5R35HL161237-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/20/2022

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT ABSTRACT/SUMMARY The gap junction (GJ) protein Connexin 43 (Cx43) has long been held to be obligate for conduction of action potential (AP) in the ventricular myocardium. However, accumulating evidence during the last two decades from non-mammals, Cx43 knockout mice and human Cx43 mutations ...

Research Terms

<Actins><Action Potentials><Acute><Animal Model><Animal Models and Related Studies><Anti-Arrhythmia Agents><Anti-Arrhythmia Drugs><Anti-Arrhythmics><Area><Arrhythmia><Biomedical Engineering><Body Tissues><Brain><Brain Nervous System><Cardiac><Cardiac Arrhythmia><Cardiac infarction><Cardiology><Cell Communication and Signaling><Cell Signaling><Clinical><Collaborations><Communicating Junction><Complex><Connexin 43><Connexin43><Connexins><Coupling><Cx43><DNA mutation><Data><Drug Design><Drug Targeting><Encephalon><Gap Junction Proteins><Gap Junctions><Gene Modified><Genetic Change><Genetic defect><Genetic mutation><Goals><Heart><Heart Arrhythmias><Hour><Human><Intracellular Communication and Signaling><Isoforms><KO mice><Knock-out Mice><Knockout Mice><Low-resistance Junction><Mammalia><Mammals><Medicine><Modern Man><Mutation><Myocardial><Myocardial Infarct><Myocardial Infarction><Myocardium><Nexus Junction><Null Mouse><Phase><Phase 3 Clinical Trials><Phase III Clinical Trials><Production><Protein Isoforms><Proteins><Reporting><Role><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Sodium Channel><Sodium Ion Channels><Sudden Death><Testing><Therapeutic><Tissues><Translating><Ventricular><Virus><arrhythmic agent><bio-engineered><bio-engineers><bioengineering><biological engineering><biological signal transduction><cardiac infarct><cardiac muscle><cardiac preservation><coronary attack><coronary infarct><coronary infarction><exosome><gene modification><genetically modified><genome mutation><heart attack><heart infarct><heart infarction><heart muscle><heart preservation><human female><iPS><iPSC><iPSCs><in silico><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><invention><ischemia injury><ischemic injury><model of animal><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><peptide mimetic><peptide mimic><peptidomimetics><pharmacologic><phase III protocol><pig model><piglet model><porcine model><response><social role><superresolution imaging><swine model><voltage>
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Benjamin Deneen

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$925,341
FY 2026

Project Title

Astrocyte Transcriptional Dependencies in Brain Circuits

Grant Number:

5R35NS132230-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

4/30/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Over the past twenty years our knowledge of astrocytes has undergone a renaissance highlighted by the identification of dynamic physiological activities, key roles in circuit function, and diverse molecular properties. Central to the physiological activities of every cell are transcr...

Research Terms

<21+ years old><AD dementia><Adult><Adult Human><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Ammon Horn><Astrocytes><Astrocytus><Astroglia><Basal Transcription Factor><Basal transcription factor genes><Brain><Brain Nervous System><CCAAT-Box Binding Transcription Factor><Cell Body><Cells><Cornu Ammonis><Degenerative Neurologic Disorders><Dependence><Development><Disease><Disorder><Dysfunction><Encephalon><Exhibits><Family><Functional disorder><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Transcription><Hippocampus><KIAA1439><Knowledge><Link><Maps><Molecular><NF-I Protein><NFI Transcription Factor><NFIA><NFIA gene><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Disorders><Neurons><Nuclear Factor I><Nuclear Factor I/A><Pathogenesis><Physiologic><Physiological><Physiopathology><Play><Primary Senile Degenerative Dementia><Property><Proteomics><RNA Expression><Renaissance><Role><Transcription><Transcription Factor NFIA><Transcription Factor Proto-Oncogene><Transcription factor genes><adulthood><aged brain><aging brain><astrocytic glia><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><epigenomics><hippocampal><member><mouse model><murine model><neurodegenerative illness><neurological disease><neuronal><nuclear factor 1><olfactory bulb><pathophysiology><primary degenerative dementia><senile dementia of the Alzheimer type><social role><transcription factor><transcriptomics>
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Walter J Atwood

BROWN UNIVERSITY, PROVIDENCE, RI

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$905,846
FY 2026

Project Title

Progressive Multifocal Leukoenephalopathy: Endemic Viruses and Lethal Brain Disease

Grant Number:

5R35NS116836-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

4/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Program Summary Progressive Multifocal Leukoencephalopathy (PML) is a major life threatening complication in patients with AIDS and in patients undergoing immunotherapy for autoimmune diseases such as multiple sclerosis, Crohn's disease, severe plaque psoriasis, systemic lupus erythematosis, hematol...

Research Terms

<AIDS patients><Anatomic Sites><Anatomic structures><Anatomy><Atrophic Arthritis><Autoimmune Diseases><Biology><Bone Marrow><Bone Marrow Reticuloendothelial System><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><CNS Diseases><CNS Nervous System><CNS disorder><Cell Body><Cells><Central Nervous System><Central Nervous System Diseases><Central Nervous System Disorders><Choroid Plexus><Chronic small plaque psoriasis><Clinic><Complication><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><Development><Discoid psoriasis><Disease><Disorder><Disseminated Sclerosis><Dysfunction><Encephalon><Encephalon Diseases><Functional disorder><Granulomatous Enteritis><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Human><Immune Surveillance><Immune mediated therapy><Immune system><Immunologic Surveillance><Immunologically Directed Therapy><Immunosurveillance><Immunotherapy><Individual><Infection><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Invaded><JC Polyomavirus><JC Polyomavirus Encephalitis><JC Polyomavirus Encephalopathy><JC Virus><Kidney><Kidney Urinary System><Life><Lupus Erythematosus Disseminatus><Lytic Cycle><Lytic Infection><Lytic Phase><Malignant Hematologic Neoplasm><Mediating><Meningeal><MicroRNAs><Modern Man><Multiple Sclerosis><Neuraxis><Nummular psoriasis><Patients><Physiopathology><Plaque psoriasis><Play><Polyoma><Polyoma Viruses><Polyomavirus><Polyomavirus JCV><Population><Progressive Multifocal Leukoencephalopathy><Psoriasis vulgaris><Receptor Protein><Regulation><Rheumatoid Arthritis><Role><SLE><Sight><Structure of choroid plexus><Systemic Lupus Erythematosus><Systemic Lupus Erythematous><Systemic Lupus Erythmatosus><Translating><Viral><Virus><Vision><Work><acquired immunodeficiency syndrome patient><autoimmune condition><autoimmune disorder><autoimmunity disease><biomarker identification><brain parenchyma><developmental><disseminated lupus erythematosus><eleocolitis><extracellular vesicles><identification of biomarkers><identification of new biomarkers><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><insular sclerosis><macroglia><marker identification><miRNA><new approaches><novel approaches><novel strategies><novel strategy><pathophysiology><patients infected with AIDS><patients with AIDS><patients with acquired immunodeficiency syndrome><prevent><preventing><programs><promoter><promotor><receptor><regional enteritis><renal><rheumatic arthritis><social role><systemic lupus erythematosis><visual function>
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David H Gutmann

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$869,826
FY 2026

Project Title

Modeling neurofibromatosis-1 disease heterogeneity to optimize risk assessment and treatment

Grant Number:

5R35NS142919-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/2/2025

End Date:

4/30/2033

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary As we envision employing personalized approaches in medical practice, it is important to define the genomic, cellular, and molecular etiologies that underlie disease pathogenesis and determine how these determinants are modified by intrinsic and extrinsic influences (risk factors). T...

Research Terms

<0-11 years old><21+ years old><Acceleration><Adult><Adult Human><Affect><Award><Bioinformatics><Body Tissues><Brain Neoplasia><Brain Neoplasms><Brain Tumors><CRISPR><CRISPR/Cas system><Causality><Cell Line><CellLine><Child><Child Youth><Children (0-21)><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Cognitive><Dependence><Development><Diagnosis><Disease><Disorder><Etiology><Exhibits><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Future><Gene Alteration><Gene Mutation><Generalized Growth><Genomics><Germ Lines><Germ-Line Mutation><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioma><Growth><Hereditary Mutation><Hortega cell><Human Engineering><Laboratories><MEKs><Malignant Cell><Mechanistic Target of Rapamycin><Medical><Mice><Mice Mammals><Microglia><Mission><Modeling><Molecular><Mouse Strains><Murine><Mus><NF-1><NF-1 Protein><NF-1 encoded protein><NF1><NF1 GRP><NF1 Protein><NF1 gene><NF1-GAP-Related Protein><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neurocyte><Neurodevelopmental Deficit><Neurofibromatosis 1><Neurofibromatosis 1 Genes><Neurofibromatosis I><Neurofibromatosis Type 1 Gene Product><Neurofibromatosis Type 1 Protein><Neurofibromin><Neurofibromin 1><Neuroglial Neoplasm><Neuroglial Tumor><Neurologic><Neurologic Body System><Neurologic Organ System><Neurological><Neurons><Outcome><Pathogenesis><Patients><Peripheral Neurofibromatosis><Personalized medical approach><Problem behavior><RAFT1><Recklinghausen Disease of Nerve><Recklinghausen's disease><Recklinghausen's neurofibromatosis><Research><Risk Assessment><Risk Factors><Signal Pathway><Strains Cell Lines><Systems Biology><T-Cells><T-Lymphocyte><Tissue Growth><Tissues><Tumor Cell><Type 1 Neurofibromatosis><Type I Neurofibromatosis><Withholding Treatment><adulthood><base><bases><behavioral problem><cancer cell><causation><cell type><cessation of treatment><clinical heterogeneity><clinical phenotype><conditional knock-out><conditional knockout><cultured cell line><design><designing><developmental><disease causation><disease heterogeneity><flexibility><flexible><gene defect><germ-line defect><germline variant><gitter cell><glial-derived tumor><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><individualized approach><induced human pluripotent stem cells><kids><mTOR><mammalian target of rapamycin><mesoglia><microglial cell><microgliocyte><multiomics><multiple omics><mutant allele><neoplastic cell><neurobehavioral><neurofibromatosis type 1 gene><neurofibromatosis type 1 protein/gene><neurogenetics><neuroglia neoplasm><neuroglia tumor><neuronal><nf 1 Genes><novel><ontogeny><panomics><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><perivascular glial cell><personalized approach><precision approach><precision medicine><precision-based medicine><programs><response><tailored approach><theories><thymus derived lymphocyte><treatment cessation><tumors in the brain><von Recklinghausen Disease><youngster>
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KIM TIEU

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$841,448
FY 2026

Project Title

Toxicant-induced neurotoxicity mediated by glia-neuron and gene-environment interactions in Parkinson's disease

Grant Number:

5R35ES030523-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2019

End Date:

4/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The long term goal of our laboratory is to study the pathogenic mechanisms induced by environmental toxicants, genetic mutations and gene-environment interactions in Parkinson’s disease (PD) with the ultimate goal of developing disease-modifying therapeutics for this brain disorder. ...

Research Terms

<1,1'-dimethyl-4,4'-bipyridinium><Address><Animals><Autophagocytosis><Bacteria><Brain Diseases><Brain Disorders><Chemicals><DA Neuron><DNA mutation><Dephosphin><Disease><Disorder><Dopamine neuron><Dynamin><Encephalon Diseases><Environmental Factor><Environmental Risk Factor><Environmental Toxin><Experimental Models><Funding><Gene x Environment Interaction><Genetic><Genetic Change><Genetic defect><Genetic mutation><Glia><Glial Cells><Goals><Grant><GxE interaction><Impairment><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Investigators><Kolliker's reticulum><Laboratories><Link><Manganese><Mediating><Methyl Viologen><Mitochondria><Mn element><Modeling><Molecular Target><Mutation><NAC precursor><NIEHS><National Institute of Environmental Health Sciences><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Neurotoxins><Non-neuronal cell><Nonneuronal cell><PARK1 protein><PARK4 protein><Paralysis Agitans><Paraquat><Parkinson><Parkinson Disease><Pathogenicity><Persons><Play><Predisposition><Primary Parkinsonism><Proteins><R-Series Research Projects><R01 Mechanism><R01 Program><Records><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Role><SNCA><SNCA protein><Sight><Stomach><Susceptibility><Techniques><Therapeutic><Toxic Environmental Agents><Toxic Environmental Substances><United States><Vision><Work><a-syn><a-synuclein><alpha synuclein><alpha synuclein gene><alphaSP22><asyn><autophagy><disease diagnosis><dopaminergic neuron><environment effect on gene><environmental risk><environmental toxicant><flexibility><flexible><gastric><gene environment interaction><genome mutation><high standard><innovate><innovation><innovative><mitochondrial><nerve cement><neuron toxicity><neuronal><neuronal toxicity><neurotoxicant><neurotoxicity><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><non A-beta component of AD amyloid><non A4 component of amyloid precursor><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><social role><tool><toxicant><visual function><α synuclein gene><α-syn><α-synuclein>
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Yinsheng Wang

UNIVERSITY OF CALIFORNIA RIVERSIDE, RIVERSIDE, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$819,653
FY 2026

Project Title

Chemical Biology of DNA and RNA Alkylation

Grant Number:

5R35ES031707-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/12/2020

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Alkylating agents are ubiquitously present in the environment, and they can alkylate DNA and RNA directly or after metabolic activation. The focus of the present R35 application is placed on the chemistry and biology of DNA and RNA alkylation, with the overarching goal of understanding the...

Research Terms

<Alkylating Agents><Alkylation><Alkylators><Approaches to prevention><Area><Biology><Bypass><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chemicals><Chemistry><DNA><DNA Alkylation><DNA Damage><DNA Damage Repair><DNA Injury><DNA Polymerases><DNA Repair><DNA Replication><DNA Synthesis><DNA biosynthesis><DNA lesion><DNA-Dependent DNA Polymerases><DNA-Directed DNA Polymerase><Deoxyribonucleic Acid><Disease><Disorder><Environment><Environmental Exposure><Environmental Toxin><Exposure to><Gene Transcription><Genetic Transcription><Genome Stability><Genomic Stability><Goals><Health><Human><Intermediary Metabolism><Intracellular Communication and Signaling><Knowledge><Metabolic Activation><Metabolic Processes><Metabolism><Modern Man><Molecular><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Non-Polyadenylated RNA><Outcome><Post-Transcriptional RNA Modification><Post-Transcriptional RNA Processing><Prevention><Prevention approach><Proteins><Proteomics><RNA><RNA Expression><RNA Gene Products><RNA methylation><Research><Ribonucleic Acid><Role><Signal Transduction><Signal Transduction Systems><Signaling><Toxic Environmental Agents><Toxic Environmental Substances><Transcription><Trinucleotide Repeat Expansion><Unscheduled DNA Synthesis><biological signal transduction><environmental chemical><environmental toxicant><epitranscriptomics><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><human disease><insight><molecular pathology><neurological disease><repair><repaired><response><social role>
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Gang Fang

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$798,207
FY 2026

Project Title

High Resolution Characterization of Bacterial Epigenomes and Microbiome

Grant Number:

2R35GM139655-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2021

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Our laboratory is recognized as a leader in bacterial epigenomics and high-resolution microbiome studies. Over the past decade, we have pioneered the use of single-molecule long-read sequencing technologies to comprehensively map bacterial DNA methylation events. This work h...

Research Terms

<Alimentary Canal><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Bacteria><Bacterial DNA><Bar Codes><Biological><Bypass><Computer software><DNA Methylation><Data><Digestive Tract><Disease><Disorder><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><Fostering><Functional Metagenomics><GI Tract><GI microbiome><Gastrointestinal Tract><Gastrointestinal tract structure><Goals><Health><Human><Immune system><Individual><Intermediary Metabolism><Investigators><Laboratories><Maps><Medical><Mentors><Metabolic Processes><Metabolism><Metagenomics><Methods><Microbe><Microbiomics><Miscellaneous Antibiotic><Mobile Genetic Elements><Modern Man><Plasmids><Play><Research><Research Personnel><Researchers><Resolution><Role><Science><Software><Stress><Systems Biology><Technology><Training><Work><alimentary tract><alter microbiome><analyze microbiome><bacteria pathogen><bacterial pathogen><barcode><biologic><commensal bacteria><commensal bacterial species><conference><contig><convention><cost effective><develop drug resistance><dietary><digestive canal><digestive tract microbiome><drug resistance development><enteric microbiome><epigenetic regulation><epigenetically><epigenome><epigenomics><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><high definition><high-resolution><improved><innovate><innovation><innovative><insight><intestinal biome><intestinal microbiome><long read seq><long-read sequencing><long-read transcript sequencing><microbiome><microbiome adaptation><microbiome alteration><microbiome analysis><microbiome perturbation><microbiome research><microbiome science><microbiome studies><microorganism><next generation><novel><pathogenic bacteria><programs><public health relevance><resolutions><response><single molecule><social role><summit><symposia><symposium><synergism><synthetic biology><tool>
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NICHOLAS K SAUTER

UNIVERSITY OF CALIF-LAWRENC BERKELEY LAB, BERKELEY, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$722,267
FY 2026

Project Title

Cctbx.xfel: Serial crystallography computational methods aimed at biomolecular function

Grant Number:

5R35GM151988-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary / Abstract Under present R01 funding, the Sauter group has focused on the use of serial crystallography to discover the structure-function relationships of large biomolecules. While specializing in technology related to data analysis, we have enabled new science at X-ray free-electro...

Research Terms

<Accounting><Algorithms><Amino Acids><Bayesian Analysis><Bayesian computation><Bayesian inference><Bayesian network analysis><Bayesian spatial analysis><Bayesian statistical analysis><Bayesian statistical inference><Bayesian statistics><Big Data><BigData><Biochemical><Biochemical Reaction><Biological><Cell Components><Cell Structure><Cellular Structures><Chemicals><Collaborations><Computer software><Computing Methodologies><Cryo-electron tomography><Crystallographies><Crystallography><Data><Data Adjustments><Data Analyses><Data Analysis><Data Collection><Development><Diffuse><Electronics><Electrons><Environment><Enzymatic Reaction><Funding><Gases><Genes><Geometry><Goals><Health><Hereditary><Heterogeneity><Human><Hydrogen Oxide><Incubated><Inherited><Laser Electromagnetic><Laser Radiation><Lasers><Learning><Light><Measurement><Metals><Methods><Modality><Modeling><Modern Man><Molecular Configuration><Molecular Conformation><Molecular Modeling Nucleic Acid Biochemistry><Molecular Modeling Protein/Amino Acid Biochemistry><Molecular Models><Molecular Stereochemistry><Monitor><Motion><Negative Beta Particle><Negatrons><Nucleic Acids><Organism><Oxidation-Reduction><Pattern><Photoradiation><Physiologic><Physiologic pulse><Physiological><Process><Proteins><Pulse><Pump><Radiation induced damage><Reaction><Redox><Regulation><Resolution><Roentgen Rays><Role><Rotation><Sampling><Science><Single Crystal Diffraction><Site><Software><Source><Spottings><Structure><Structure-Activity Relationship><Supercomputing><Synchrotrons><Technology><Temperature><Time><Water><X Ray Crystallographies><X Ray Emission Spectroscopy><X-Radiation><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray Radiation><X-Ray/Neutron Crystallography><X-ray><Xray><Xray Crystallography><Xray Emission Spectroscopy><Xray free electron laser><absorption><aminoacid><biologic><chemical structure function><computational methodology><computational methods><computer based method><computer methods><computerized data processing><computing method><conformation><conformational><conformational state><conformationally><conformations><cost><cryo-EM tomography><cryoEM tomography><cryoelectron tomography><data interpretation><data processing><detector><developmental><electron cryo-tomography><electronic><electronic device><experiment><experimental research><experimental study><experiments><flexibility><flexible><improved><instrumentation><living system><macromolecule><metalloenzyme><molecular modeling><oxidation reduction reaction><radiation damage><resolutions><risk mitigation><small molecule><social role><spatial and temporal><spatial temporal><spatiotemporal><structure function relationship><super computing><temperature jump><terabyte><x-ray FEL><x-ray free-electron laser>
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Hanrui Zhang

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$656,633
FY 2026

Project Title

Finding and pushing the limits of macrophage efferocytosis in atherosclerosis

Grant Number:

5R35HL177389-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

4/30/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The search for mechanism-driven therapeutic targets in atherosclerosis remains ongoing and the scientific community needs breakthroughs to identify novel therapeutic strategies to further reduce the residual risk of atherosclerotic cardiovascular disease (ACVD). Preclinical, clinical...

Research Terms

<ASCVD><Acute><Assay><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Autoimmune Diseases><Bioassay><Biological Assay><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas9 screen><Cancers><Carotid Artery Plaques><Clinical><Clinical Research><Clinical Study><Communities><Coronary Arteriosclerosis><Coronary Artery Disease><Coronary Artery Disorder><Coronary Atherosclerosis><Digestion><Disease><Disorder><Eating><Food Intake><Genes><Genomics><Heart Injuries><Heterogeneity><Human><Human Genetics><Image><Impaired tissue repair><Impaired wound healing><Knock-out><Knockout><Knowledge><Macrophage><Malignant Neoplasms><Malignant Tumor><Mediating><Modern Man><Molecular><Mφ><Phase><Polyploid><Polyploidy><Residual><Residual state><Risk><Sight><Therapeutic><Transgenic Mice><Vision><abnormal tissue repair><atheromatosis><atherosclerosis risk><atherosclerotic coronary disease><atherosclerotic disease><atherosclerotic risk><atherosclerotic vascular disease><autoimmune condition><autoimmune disorder><autoimmunity disease><candidate identification><cardiac injury><carotid plaque><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><clustered regularly interspaced short palindromic repeats screen><coronary arterial disease><delayed wound healing><deliver short interfering RNA><deliver siRNA><deliver small interfering RNA><delivery system for siRNA><delivery system for small interfering RNA><delivery vectors for siRNA><functional genomics><genome scale><genome-wide><genomewide><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSCs><imaging><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><malignancy><mouse model><murine model><nano particle><nano-sized particle><nanoparticle><nanosized particle><neoplasm/cancer><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pre-clinical><preclinical><programs><screening><screenings><short interfering RNA delivery><siRNA delivery><small interfering RNA delivery><success><therapeutic target><translational pipeline><translational spectrum><translational study><visual function>
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JAMES E BEAR

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$588,330
FY 2026

Project Title

Systematic Analysis of the Actin Cytoskeleton and Directed Cell Migration

Grant Number:

5R35GM130312-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2019

End Date:

4/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT ABSTRACT Cell motility is one of the oldest problems in cell biology as the movement of cells was one of the first things noted when the microscope was developed in the 17th century. The last sixty years of work revealed that the molecular underpinnings of motility involve the active control...

Research Terms

<Actins><Architecture><Area><Assay><Bioassay><Biochemical><Biological Assay><Biological Function><Biological Process><Cardiovascular Diseases><Cause of Death><Cell Adhesion><Cell Body><Cell Function><Cell Locomotion><Cell Migration><Cell Movement><Cell Physiology><Cell Process><Cell Shape><Cells><Cellular Adhesion><Cellular Function><Cellular Matrix><Cellular Migration><Cellular Motility><Cellular Physiology><Cellular Process><Cellular biology><Characteristics><Clathrin><Cues><Cytoskeletal System><Cytoskeleton><Data><Disease><Disorder><Disseminated Malignant Neoplasm><EPH- and ELK-Related Tyrosine Kinase><EPH-and ELK-Related Kinase><Embryo Development><Embryogenesis><Embryonic Development><Endocytosis><Engineering / Architecture><Environment><Ephrin Type-A Receptor 8><Ephrin Type-A Receptor 8 Precursor><Equilibrium><Fibrosis><Genes><Grant><Image Analyses><Image Analysis><Immune response><Integrins><Integrins Extracellular Matrix><KO mice><Knock-out Mice><Knockout Mice><Light><Mediating><Metastasis><Metastasize><Metastatic Cancer><Metastatic Lesion><Metastatic Malignant Neoplasm><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Microscope><Microscopy><Molecular><Morphogenesis><Motility><Neoplasm Metastasis><Null Mouse><Organism-Level Process><Organismal Process><Pathologic Processes><Pathological Processes><Pathway interactions><Photoradiation><Physiologic Processes><Physiological Processes><Play><Protein Tyrosine Kinase><Protein Tyrosine Kinase EEK><Proteomics><Publishing><Regulation><Role><Secondary Neoplasm><Secondary Tumor><Signal Pathway><Subcellular Process><Testing><Traction><Tyrosine Kinase><Tyrosine-Protein Kinase Receptor EEK><Tyrosine-Specific Protein Kinase><Tyrosylprotein Kinase><Work><Wound Repair><active control><balance><balance function><cancer metastasis><cardiovascular disorder><cell biology><cell motility><conditional knock-out><conditional knockout><host response><hydroxyaryl protein kinase><image evaluation><image interpretation><immune system response><immunoresponse><interdisciplinary approach><intracellular skeleton><migration><morphogenetic process><mouse model><multidisciplinary approach><murine model><optogenetics><pathway><response><social role><tumor><tumor cell metastasis><tyrosyl protein kinase><wound healing><wound recovery><wound resolution>
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Adam Charles Siepel

COLD SPRING HARBOR LABORATORY, COLD SPRING HARBOR, NY

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$576,000
FY 2026

Project Title

Evolutionary Human Genomics: Demography, Natural Selection, and Transcriptional Regulation

Grant Number:

5R35GM127070-09

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2018

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary My research program aims to make sense of modern genomic data through the lens of molecular evolution. Drawing from ideas and techniques in statistics, artificial intelligence, and population genetics, we seek both to understand the evolutionary forces that have shaped present-day ge...

Research Terms

<AI system><Address><Alleles><Allelomorphs><Area><Artificial Intelligence><Aves><Avian><Bats><Birds><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas9 screen><Cancers><Chiroptera><Computer Reasoning><Computer Software Tools><Computing Methodologies><DNA Recombination><DNA mutation><Data><Demography><Detection><Enhancers><Essential Genes><Event><Evolution><Funding><Gene Expression><Genes><Genetic Change><Genetic Differentiation><Genetic Divergence><Genetic Diversity><Genetic Drift><Genetic Recombination><Genetic Variation><Genetic defect><Genetic mutation><Genome><Genomics><Goals><Graph><Health><Human><Human Biology><Immunity><Light><Link><Machine Intelligence><Malignant Neoplasms><Malignant Tumor><Mammalia><Mammals><Measures><Methodology><Methods><Modern Man><Modernization><Molecular Evolution><Mutation><Natural Selections><Non-Polyadenylated RNA><Paper><Pattern><Phenotype><Photoradiation><Phylogeny><Polygenic Characters><Polygenic Inheritances><Polygenic Traits><Population><Population Genetics><Printing><Productivity><Publishing><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Radiation><Recombination><Regulatory Element><Research><Ribonucleic Acid><Sampling><Series><Shapes><Software Tools><South American><Techniques><Training><Transcriptional Control><Transcriptional Regulation><Variant><Variation><Work><biophysical model><clustered regularly interspaced short palindromic repeats screen><comparative genomics><computational methodology><computational methods><computer based method><computer methods><computing method><deep learning based neural network><deep learning neural network><deep neural net><deep neural network><epigenomics><fitness><genome mutation><genomic data><genomic dataset><graph attention network><graph convolutional network><graph neural network><human disease><human genomics><innovate><innovation><innovative><insight><intelligence genetics><lens><lenses><malignancy><neoplasm/cancer><novel><programs><promoter><promotor><reconstruction><software toolkit><statistics><transcriptome sequencing><transcriptomic sequencing>
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JAMES A WELLS

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$572,243
FY 2026

Project Title

Surfaceomic technologies and antibodies to probe cell surface proteomes and their interactomes at unprecedented small scale and high-resolution

Grant Number:

5R35GM122451-09

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

4/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Title: Surfaceomic technologies and antibodies to probe cell surface proteomes and their interactomes at unprecedented small scale and high-resolution Project summary The cell surfaceome is the primary hub that allows cells to sense and respond to changes in their environment, yet only a minority of...

Research Terms

<Advanced Development><Anti-Cancer Agents><Antibodies><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Bacteriophages><Biological Markers><Cancer Drug><Cancer Genes><Cancer-Promoting Gene><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Surface Proteins><Cell membrane><Cell surface><Cells><Complex><Cytokine Receptors><Cytoplasmic Membrane><Development><Disease><Disorder><Drug Targeting><EGF Receptor><EGFR><ERBB Protein><Energy Transfer><Environment><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><Family><Generations><Goals><Grant><HER1><Health><Immunology><Intracellular Communication and Signaling><Label><Malignant Neoplasms><Malignant Tumor><Maps><Mediating><Membrane><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Methods><Minority><Modeling><Neoplastic Disease Chemotherapeutic Agents><Nerve Degeneration><Neurology><Neuron Degeneration><Oncogenes><Patients><Phages><Phenotype><Plasma Membrane><Population><Process><Protein Secretion><Proteome><Proteomics><Receptor Protein><Recombinants><Regulation><Sampling><Science><Sight><Signal Transduction><Signal Transduction Systems><Signaling><Surface Proteins><T-Cells><T-Lymphocyte><TGF-alpha Receptor><Techniques><Technology><Transforming Genes><Transforming Growth Factor alpha Receptor><Tumor-Specific Treatment Agents><Urogastrone Receptor><Vision><Yeasts><anti-cancer drug><bacterial virus><bio-markers><biologic marker><biological signal transduction><biomarker><c-erbB-1><c-erbB-1 Protein><cell type><developmental><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><high definition><high-resolution><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><malignancy><membrane structure><neoplasm/cancer><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><plasmalemma><protein complex><proto-oncogene protein c-erbB-1><receptor><thymus derived lymphocyte><visual function>
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Maria Christina White

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$549,475
FY 2026

Project Title

Selective C(sp3)-H Oxidations and Functionalizations with Tunable Metal Catalysts for Synthesis

Grant Number:

5R35GM122525-10

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2017

End Date:

4/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PI, White, M.C.    R35 GM 122525    1  Project Summary 2  3  The atomistic change of C(sp3)–H to C(sp3)–O, –N, or –C can profoundly impact the biological function and 4  physical properties of small molecules. Traditionally, introducing these functionalities relies on functional group 5  trans...

Research Terms

<3-D><3-Dimensional><3D><Alcohol Chemical Class><Alcohols><Alkylation><Amination><Area><Biological><Biological Function><Biological Process><Carbon><Chemistry><Communities><Complex><Coupling><Drugs><Electronics><Fe element><Foundations><H-bond><Hydrocarbons><Hydrogen Bonding><Individual><Industrialization><Iron><Ligands><Manganese><Medication><Metals><Mn element><Natural Products><Outcome><Palladium><Pd element><Pharmaceutical Preparations><Process><Property><Reaction><Site><Sulfoxide><Technology><Therapeutic><Work><base><bases><biologic><catalyst><chemical synthesis><commercialization><drug candidate><drug discovery><drug/agent><electronic><electronic device><empowerment><functional group><innovate><innovation><innovative><invention><metal complex><naturally occurring product><novel><oxidation><phthalocyanine><physical property><programs><scaffold><scaffolding><small molecule><three dimensional>
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Jose Aron Lopez

BLOODWORKS, SEATTLE, WA

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$1,204,271
FY 2026

Project Title

Molecular and Translational Studies in Hematologic Disorders

Grant Number:

5R35HL177719-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

This application for an NHLBI R35 Outstanding Investigator Award is to continue R35-funded studies on mech- anism of disease in von Willebrand Disease (VWD) and sickle cell disease (SCD). Both diseases involve von Willebrand factor (VWF). In VWD, VWF has a starring role; in SCD, it is one of many ac...

Research Terms

<1-Alkyl-2-acetyl-sn-glycerophosphocholine><1-O-alkyl-2-acetyl-sn-glycero-3-phosphocholine><ADAMTS><AGEPC><AI Augmented><AI assisted><AI driven><AI enhanced><AI integrated><AI powered><Acetyl Glyceryl Ether Phosphorylcholine><Address><Agonist><Angiohemophilia><Artificial Intelligence enhanced><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Award><Binding><Biological Markers><Blood><Blood Diseases><Blood Plasma><Blood Platelets><Blood Reticuloendothelial System><Blood erythrocyte><Blood leukocyte><Complex><Disease><Disorder><Docking><Dysfunction><Endothelial Cells><Erythrocyte Cytoskeleton><Erythrocyte Membrane><Erythrocytes><Erythrocytic><Functional disorder><Funding><HDL><HDL Lipoproteins><Hb SS disease><HbSS disease><Heavy Lipoproteins><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hemostasis><Hemostatic Agents><Hemostatic function><Hemostatics><High Density Lipoproteins><In Vitro><Inflammatory><Intervention><Investigators><Leukocytes><Leukocytes Reticuloendothelial System><Lipids><Lipoproteins><Lysophospholipids><Marrow erythrocyte><Marrow leukocyte><Marrow platelet><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Microfluidics><Molecular><Molecular Interaction><NHLBI><National Heart, Lung, and Blood Institute><PAF-Acether><Patients><Phosphatides><Phospholipids><Physiopathology><Plasma><Plasma Serum><Platelet Activating Factor><Platelet-Activating Substance><Platelets><Play><Probability><Recombinant Proteins><Red Blood Cells><Red Cell><Research Personnel><Researchers><Reticuloendothelial System, Serum, Plasma><Ristocetin Cofactor><Ristocetin-Willebrand Factor><Role><Sickle Cell><Sickle Cell Anemia><Structure><Techniques><Testing><Thrombocytes><Vascular Hemophilia><Von willebrand factor deficiency><White Blood Cells><White Cell><Willebrand disease><Work><alpha-Lipoproteins><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><bio-markers><biologic marker><biomarker><blood corpuscles><blood disorder><candidate identification><cleavage factor><enhanced with AI><enhanced with Artificial Intelligence><improved><in vivo><intra-vital microscopy><intravital microscopy><lipidome><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oxidation><oxidized lipid><pathophysiology><sickle RBC><sickle cell disease><sickle cell disorder><sickle disease><sickle erythrocyte><sickle red blood cell><sicklemia><social role><translational study><vaso-occlusive crisis><vasoocclusive crisis><von Willebrand Disease><von Willebrand Factor><von Willebrand Protein><white blood cell><white blood corpuscle><µfluidic>
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Donna D Zhang

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$1,154,486
FY 2026

Project Title

NRF Transcription Factors in Environmental Stress and Disease Intervention

Grant Number:

5R35ES031575-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2020

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Title: NRF transcription factors in Environmental Stress and Disease Intervention PROJECT SUMMARY My broad research program includes in-depth mechanistic investigations of arsenic pathogenesis/NRF signaling and the translation of basic mechanistic knowledge to preclinical drug development. Chronic ...

Research Terms

<Address><Adult-Onset Diabetes Mellitus><Affect><Arsenic><Basal Transcription Factor><Basal transcription factor genes><Cancers><Cell Communication and Signaling><Cell Signaling><Cellular Stress><Cellular Stress Response><Chronic><Darkness><Disease><Disorder><Environmental Health><Environmental Health Science><Environmental Pollutants><Exposure to><Family member><General Transcription Factor Gene><General Transcription Factors><Generations><Goals><Health><Human><Intervention><Intracellular Communication and Signaling><Investigation><Ketosis-Resistant Diabetes Mellitus><Knowledge><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Maturity-Onset Diabetes Mellitus><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Modern Man><Molecular><NIDDM><Neoplasm Metastasis><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Oxidative Stress><Pathogenesis><Pathologic><Pathology><Pathway interactions><Persons><Pre-clinical Drug Testing/Development><Preclinical Drug Development><Preclinical Drug Testing/Development><Public Health><Pulmonary Cancer><Pulmonary malignant Neoplasm><Research><Risk><Role><Secondary Neoplasm><Secondary Tumor><Side><Sight><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Stress><System><T2 DM><T2D><T2DM><Therapeutic><Transcription Factor Proto-Oncogene><Transcription factor genes><Translations><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Upregulation><Vision><adult onset diabetes><arsenics><biological signal transduction><cancer initiation><cancer metastasis><cancer progression><cancer type><cell stress><diabetogenic><environmental contaminant><improved><inhibitor><innovate><innovation><innovative><ketosis resistant diabetes><lung cancer><malignancy><maturity onset diabetes><neoplasm progression><neoplasm/cancer><neoplastic progression><pathway><pre-clinical drug development><prevent><preventing><programs><resistance to therapy><resistant to therapy><response><social role><therapeutic resistance><therapy resistant><transcription factor><translation><treatment resistance><tumor cell metastasis><tumor progression><type 2 DM><type II DM><type two diabetes><unpublished works><visual function>
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Ira A Tabas

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$1,151,500
FY 2026

Project Title

A Program Investigating New Concepts ofMacrophage Biology in Atherosclerosis and Atherosclerosis-MASH Cardiometabolic Disease

Grant Number:

1R35HL183005-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/9/2026

End Date:

2/28/2033

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

We propose a comprehensive, long-term program that addresses major gaps in our understanding of athero- sclerotic cardiovascular disease (CVD) and cardiometabolic disease. We explore new, disruptive concepts re- lated to the roles of the macrophage (Mφ) efferocytosis-resolution cycle in promoting a ...

Research Terms

<ASCVD><Acute><Address><Area><Arterial Fatty Streak><Atheroma><Atheromatous><Atheromatous degeneration><Atheromatous plaque><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Atherosclerotic cap><Award><Biology><Cardiac Diseases><Cardiac Disorders><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cells><Cellular Stress><Cellular Stress Response><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Communities><Dangerousness><Data><Defect><Development><Disease><Disorder><Etiology><Event><Fibrosis><Fibrous Cap><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Goals><Heart Diseases><Heart Vascular><Hepatic Disorder><Human><Immune><Immunes><Impairment><Intracellular Communication and Signaling><Investigators><Knowledge><Lead><Lesion><Link><Liver><Liver Fibrosis><Liver diseases><Macrophage><Mediating><Mentors><Metabolic dysfunction><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Mφ><NASH><NHLBI><National Heart, Lung, and Blood Institute><Obesity><Pathogenicity><Pathway interactions><Pb element><Phenotype><RNA based therapeutics><RNA based therapy><RNA targeting drug><RNA targeting therapeutics><RNA therapy><RNA-targeting therapy><Recombinant DNA Technology><Regulatory T-Lymphocyte><Research><Research Personnel><Researchers><Resolution><Risk Factors><Role><Scientist><Services><Signal Transduction><Signal Transduction Systems><Signaling><Steatohepatitis><Syndrome><Testing><Therapeutically Targetable><Training><Translations><Treg><Work><adiposity><age associated><age correlated><age dependent><age linked><age related><age specific><atheromatosis><atherosclerosis plaque><atherosclerotic disease><atherosclerotic lesions><atherosclerotic plaque><atherosclerotic vascular disease><biological signal transduction><cardiovascular disorder><causation><cell based intervention><cell mediated intervention><cell mediated therapies><cell stress><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><circulatory system><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><corpulence><developmental><disease causation><fibrotic liver><genetically engineered><heart disorder><heavy metal Pb><heavy metal lead><hematopoietic cell clones><hematopoietic stem cell clonality><hepatic body system><hepatic disease><hepatic fibrosis><hepatic organ system><hepatopathy><interest><liver disorder><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><non-alcohol induced steatohepatitis><non-alcoholic steato-hepatitis><non-alcoholic steatohepatitis><nonalcoholic steato-hepatitis><nonalcoholic steatohepatitis><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><oxidative DNA damage><pathway><plaque cap><plaques in atherosclerosis><programs><regulatory T-cells><repair><repaired><resolutions><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><therapeutic RNA><therapeutic target><translation><uptake>
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DANIEL PATRICK KELLY

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$1,114,748
FY 2026

Project Title

Locking and Unlocking Cardiac Maturation

Grant Number:

5R35HL177035-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

SUMMARY Significant progress has been made in defining the events involved in early cardiac development. Much less is known about the developmental maturation process that begins in late fetal stages and proceeds into the postnatal period, resulting in the terminally differentiated adult heart. Deci...

Research Terms

<21+ years old><Address><Adult><Adult Human><Basal Transcription Factor><Basal transcription factor genes><Binding Sites><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Malformation><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac development><Cardiocyte><Cardiomyopathies><Combining Site><DNA><Deoxyribonucleic Acid><Development><Disease><Disorder><ERR1 protein><ERRalpha><Enhancers><Event><Functional RNA><Funding><GATA binding protein 4><GATA4><GATA4 gene><GATA4 transcription factor><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Transcription><Genomics><Goals><Heart><Heart Diseases><Heart Malformation><Heart Muscle Cells><Heart failure><Heart myocyte><Human><Laboratories><Metabolic><Mitochondria><Modern Man><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><NHLBI><National Heart, Lung, and Blood Institute><Natural regeneration><Noncoding RNA><Nontranslated RNA><Nuclear Orphan Receptor><PPAR gamma><PPAR-g><PPAR-γ><PPARgamma><PPARγ><Peroxisome Proliferative Activated Receptor Gamma><Peroxisome Proliferator-Activated Receptor gamma><Peroxisome Proliferator-Activated Receptor γ><Process><Productivity><Proliferating><RNA Expression><Reactive Site><Receptor Protein><Regeneration><Regulation><Research Support><Series><Thiazolidinedione Receptor><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Untranslated RNA><Variant><Variation><abnormal heart development><adulthood><cardiac failure><cardiogenesis><cardiomyocyte><congenital cardiac abnormality><congenital cardiac anomalies><congenital cardiac disease><congenital cardiac disorder><congenital cardiac malformation><congenital heart abnormality><congenital heart anomaly><congenital heart disease><congenital heart disorder><congenital heart malformation><developmental><estrogen-related receptor><estrogen-related receptor 1><estrogen-related receptor alpha><fetal><heart development><heart disorder><heart formation><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><induced human pluripotent stem cells><low-frequency mutation><mitochondrial><myocardium disease><myocardium disorder><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><noncoding><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><post-natal period><postnatal><postnatal period><prevent><preventing><programs><rare allele><rare mutation><rare variant><receptor><regenerate><stem><transcription factor><translational impact>
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David Alan Kass

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$1,089,224
FY 2026

Project Title

Intersection of Obesity and Heart Failure with Preserved Ejection Fraction

Grant Number:

5R35HL166565-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/20/2023

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

This project will elucidate the biological mechanisms by which obesity alters the myocardium in patients with heart failure and a preserved ejection fraction (HFpEF) to ultimately derive sorely needed precision- guided therapies. HFpEF currently represents more than half of all heart failure worldwi...

Research Terms

<Abnormal Assessment of Metabolism><Actin Filaments><Affect><African American><Afro American><Afroamerican><Animal Model><Animal Models and Related Studies><Benchmarking><Best Practice Analysis><Biological><Calcium><Cardiac><Causality><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Citrates><Citric Acid Cycle><Clinical><Contracting Opportunities><Contracts><Dedications><Depressed mood><Diabetes Mellitus><Diastolic heart failure><Disease><Disorder><EFRAC><Ejection Fraction><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Female><Fibrosis><Fumarates><Gene Expression><Genes><HF with preserved ejection fraction><HFpEF><Heart><Heart Muscle tissue><Heart failure><Histone Acetylation><Human><Hypertension><Hypertrophy><Intermediary Metabolism><Knowledge><Krebs Cycle><Medical><Medicine><Metabolic><Metabolic Processes><Metabolic Studies><Metabolic syndrome><Metabolism><Metabolism Studies><Microfilaments><Modeling><Modern Man><Molecular><Morbidity><Motor><Muscle Cells><Myocardial><Myocardial tissue><Myocardium><Myocytes><Myofilaments><NIH><National Institutes of Health><Obesity><Organ><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Patients><Performance><Phenotype><Physiology><Polyamine Compound><Polyamines><Prevalence><Prognosis><Proteins><Regulatory Protein><Sarcomeres><Stress><Subcellular Process><Succinates><Syndrome><TCA cycle><Testing><Tricarboxylic Acid Cycle><United States National Institutes of Health><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><adiposity><benchmark><biologic><cardiac failure><cardiac metabolism><cardiac muscle><causation><corpulence><depressed><diabetes><disease causation><effective therapy><effective treatment><epigenetically><fat metabolism><flexibility><flexible><genetic regulatory protein><glucose metabolism><heart failure with preserved ejection fraction><heart failure with preserved systolic function><heart metabolism><heart muscle><hemodynamics><high blood pressure><histone methylation><histone modification><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><insight><interest><lipid metabolism><metabolic abnormality assessment><model of animal><mortality><myocardial biopsy><novel><obese patients><patients with obesity><preservation><preserved ejection fraction heart failure><programs><regulatory gene product><sadness><♀>
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Ye Chen-Izu

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$1,087,577
FY 2026

Project Title

Mechanical Load Effects on Cardiac Function and Heart Diseases

Grant Number:

5R35HL166575-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Significance: In every heartbeat, cardiac muscle cells generate contractile force to pump blood into circulation against a mechanical load. Cardiomyocytes also sense load changes and adjust the contractility to maintain cardiac output. Excessive overload in pathological conditions leads to heart dis...

Research Terms

<Affect><Arrhythmia><Biology><Cardiac><Cardiac Arrhythmia><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac Output><Cardiocyte><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Mechanotransduction><Chemistry><Circulation><Contracting Opportunities><Contracts><Coupling><Diastolic heart failure><Disease><Disorder><Feedback><Gel><Goals><HF with preserved ejection fraction><HFpEF><Health><Heart><Heart Arrhythmias><Heart Diseases><Heart Muscle Cells><Heart failure><Heart myocyte><History><Hypertension><Intracellular Communication and Signaling><Knowledge><Mechanical Signal Transduction><Mechanical Stress><Mechanosensory Transduction><Methods><Modeling><Molecular><Molecular Target><Myocardial depression><Myocardial dysfunction><Myocardium><Outcome><Outcomes Research><Pathologic><Pathway interactions><Physics><Pump><Recording of previous events><Research><STEM research><Signal Transduction><Signal Transduction Systems><Signaling><Technology><Therapeutic><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Work><biological signal transduction><blood pump><cardiac dysfunction><cardiac failure><cardiac function><cardiac muscle><cardiomyocyte><design><designing><dynamic system><dynamical system><experiment><experimental research><experimental study><experiments><function of the heart><heart disorder><heart dysfunction><heart failure with preserved ejection fraction><heart failure with preserved systolic function><heart function><heart muscle><heart output><high blood pressure><histories><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><innovate><innovation><innovative><innovative technologies><interdisciplinary approach><mechanical load><mechanosensing><mechanotransduction><multidisciplinary approach><new drug treatments><new drugs><new pharmacological therapeutic><new technology><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel technologies><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><pathway><preserved ejection fraction heart failure><response><science, technology, engineering and math research><science, technology, engineering and mathematics research>
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Zaijie Jim Wang

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$1,048,594
FY 2026

Project Title

Molecular Mechanism and Targeting of Chronic Pain in Sickle Cell Disease

Grant Number:

5R35HL177406-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Our long-term goal is to advance the knowledge of the molecular and neurobiological mechanisms underlying chronic pain in sickle cell disease (SCD) and develop effective pharmacologic treatments. Pain is not only a life-long companion but also a predictor of mortality for the 100,000 Americans, mill...

Research Terms

<Acute Pain><Acutely painful><African><American><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Chronic><Clinical><Companions><Data><Development><Disease><Disorder><Drug Delivery><Drug Delivery Systems><Drug Targeting><Drug Therapy><Emergent Technologies><Emerging Technologies><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Experimental Therapies><Future><GI microbiota><Gastrointestinal microbiota><Goals><Hb SS disease><HbSS disease><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Human><Investigational Therapies><Investigational Treatments><Knowledge><Literature><MicroRNAs><Modern Man><Molecular><Molecular and Cellular Biology><Neurobiology><Pain><Painful><Paper><Patients><Pharmacological Treatment><Pharmacology><Pharmacotherapy><Phase I Study><Probability><Refractory><Research><Seminal><Sickle Cell><Sickle Cell Anemia><Study models><Transgenic Mice><Transgenic Model><Translational Research><Translational Science><Tribes><Tyrosine 3-Monooxygenase><Tyrosine Hydroxylase><chronic pain><design><designing><developmental><disease phenotype><drug candidate><drug intervention><drug treatment><effective therapy><effective treatment><enteric microbial community><enteric microbiota><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><experience><experimental therapeutic agents><experimental therapeutics><flexibility><flexible><gastrointestinal microbial flora><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><innovate><innovation><innovative><intestinal flora><intestinal microbiota><intestinal microflora><intestinal tract microflora><miRNA><mortality><mouse model><murine model><neurobiological><neurobiological mechanism><pain killer><pain medication><pain reliever><painkiller><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phase 1 study><programs><sickle RBC><sickle cell disease><sickle cell disorder><sickle disease><sickle erythrocyte><sickle red blood cell><sicklemia><sickling><success><tool><transgenic trait><translation research><translational investigation>
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DIANNE R NEUMARK-SZTAINER

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$1,025,593
FY 2026

Project Title

Promoting weight-related health in the next generation of adolescents and young adults:A comprehensive program of research

Grant Number:

5R35HL177136-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

3/31/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Promoting weight-related health is vital to cardiovascular health and a public health priority. The Project EAT (Eating and Activity over Time) research has informed a paradigm shift regarding how to address weight- related health. Specifically, findings have shown the need to address the ...

Research Terms

<0-11 years old><Address><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adult Children><Adult Daughters><Adult Offspring><Adult Sons><Binge Eating><Body Image><Body Weight decreased><Child><Child Youth><Children (0-21)><Communities><Data><Data Collection><Data Set><Data Sources><Dedications><Dietary intake><Drugs><Eating><Eating Disorders><Ethnic Origin><Ethnicity><Exposure to><Food Intake><Future><Generations><Goals><Health><Health Care Providers><Health Personnel><Image><Investigators><Medication><NHLBI><National Heart, Lung, and Blood Institute><Obesity><Outcome><Parents><Persons><Pharmaceutical Preparations><Physical activity><Population Study><Productivity><Proliferating><Race><Races><Research><Research Personnel><Researchers><Sampling><Science><Scientist><Social Environment><Socio-economic status><Socioeconomic Status><Strategic vision><Survey Instrument><Surveys><Technology><TikTok><Time><Training><Weight><Weight Loss><Weight Reduction><Weight maintenance regimen><Work><adiposity><adult youth><body dissatisfaction><body perception><body weight loss><cardiovascular health><cohort><community advisory board><community advisory committee><community advisory panel><community engagement><community partners><community partnership><community-based partners><compulsive eating><compulsive feeding><compulsive overeating><corpulence><disadvantaged background><drug/agent><engagement with communities><health care personnel><health care worker><health equity><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><imaging><innovate><innovation><innovative><intergenerational><juvenile><juvenile human><kids><marginalized background><medical care providers><medical personnel><member><next generation><parent><population research study><population survey><population-based study><population-level study><prevent><preventing><programs><public health priorities><racial><racial background><racial origin><response><social climate><social context><social determinants><social media><socio-economic position><sociodeterminant><socioeconomic position><socioenvironment><socioenvironmental><treatment provider><weight control><weight management><weights><wt-loss><young adult><young adult age><young adulthood><youngster>
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LEONARD PETRUCELLI

MAYO CLINIC JACKSONVILLE, JACKSONVILLE, FL

Good lead · 66/100
Likely hiring
Large award
Active award
$1,138,538
FY 2026

Project Title

Expanding insights into FTD disease mechanisms

Grant Number:

5R35NS137447-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT Frontotemporal lobar degeneration (FTLD), which underlies frontotemporal dementia (FTD), encompasses a group of disorders with significant genetic, clinical, and neuropathological heterogeneity. FTLD is also genetically and pathologically associated with the motor neuron dis...

Research Terms

<Acceleration><Address><Adopted><Affect><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Area><Behavior><Biological Markers><Brain><Brain Nervous System><C9ORF72><COVID-19><CV-19><Cell Body><Cells><Clinic><Clinical><Collaborations><Communities><Coronavirus Infectious Disease 2019><DNA mutation><Dedications><Degenerative Neurologic Disorders><Deposit><Deposition><Development><Disease><Disease Progression><Disorder><Dominantly-Inherited Spinocerebellar Ataxias><Dysfunction><Encephalon><Environment><FTD dementia><FTLD><Fostering><Frontal Temporal Dementia><Frontal Temporal Lobar Degeneration><Frontotemporal Dementia><Frontotemporal Lobar Degenerations><Frontotemporal variety lobar degeneration><Functional disorder><Funding><Funding Opportunities><Gehrig's Disease><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Heterogeneity><Histology><Language><Lou Gehrig Disease><MT-bound tau><Mediating><Mice><Mice Mammals><Molecular><Monitor><Motor Neuron Disease><Murine><Mus><Mutation><Nature><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurosciences><Non-Polyadenylated RNA><PC cell-derived growth factor><PCDGF><PGRN gene><PGRN protein><Pathogenesis><Pathogenicity><Pathologic><Patients><Personality><Physicians><Physiopathology><Process><Productivity><Progranulin><Proteins><Proteomics><Publications><RNA><RNA Gene Products><RNA Splicing><Research><Research Resources><Resources><Ribonucleic Acid><Role><Science><Scientific Publication><Scientist><Seminal><Spinocerebellar Ataxias><Spinocerebellar Atrophies><Splicing><System><TAR DNA binding protein 43 kDa pathology><TAR DNA binding protein 43 pathology><TAR DNA binding protein of 43 proteinopathy><TAR DNA-binding protein 43><TDP-43><TDP43><TDP43 associated neurodegeneration><TDP43 associated neurodegenerative disease><TDP43 associated pathologies><TDP43 induced neurodegeneration><TDP43 neurodegeneration><TDP43 neurodegenerative disease><TDP43 neuropathology><TDP43 pathogenesis><TDP43 pathology><TDP43 proteinopathy><TDP43 related neurodegeneration><TDP43 related pathology><Tauopathies><Techniques><Trans active response DNA binding protein 43 pathology><Trans active response DNA binding protein of 43 kDa proteinopathy><Translational Research><Translational Science><Work><bio-markers><biologic marker><biomarker><chromosome 9 open reading frame 72><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><degenerative diseases of motor and sensory neurons><degenerative disorder of motor neurons><degenerative neurological diseases><developmental><fibrillogenesis><flexibility><flexible><forging><front temporal dementia><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><genome mutation><granulin precursor><human tissue><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><insight><interest><microtubule bound tau><microtubule-bound tau><mouse model><murine model><neurodegenerative illness><neuropathologic><neuropathologic tau><neuropathological><neuropathological tau><neuropathology><novel><pathophysiology><patient prognosis><prevent><preventing><progenitor cell model><progenitor model><programs><progranulin gene><progranulin protein><protein TDP-43><protein TDP43><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><tool><trans active response DNA binding protein 43 kDa pathology><trans active response DNA binding protein 43 proteinopathy><transcriptomics><translation research><translational investigation><τ Proteins>
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Aaron D. Gitler

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100
Likely hiring
Large award
Active award
$1,125,530
FY 2026

Project Title

Innovating next generation technologies to define mechanisms of neurodegenerative disease and devise therapeutic strategies

Grant Number:

5R35NS137159-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/18/2024

End Date:

11/30/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary/Abstract: This is a proposal to consolidate our NINDS research projects into one larger R35 award, enabling us the time and flexibility to explore important biological questions relevant to human neurodegenerative diseases. My laboratory has used a combination of yeast and human gen...

Research Terms

<21+ years old><Adult><Adult Human><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Amyotrophic lateral sclerosis and frontotemporal degeneration><Amyotrophic lateral sclerosis and frontotemporal dementia><Award><Biological><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cells><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><DNA mutation><Degenerative Neurologic Disorders><Development><Event><Exons><FTD/ALS><FTLD/ALS><Family><Foundations><Frontotemporal Lobar Degeneration/Amyotrophic lateral sclerosis><GWA study><GWAS><Gehrig's Disease><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Screening><Genetic Variation><Genetic defect><Genetic mutation><Genetic predisposing factor><Heterogeneity><Human><Human Genetics><In Vitro><Individual><Knock-out><Knockout><Laboratories><Length><Lou Gehrig Disease><Medulla Spinalis><Mice><Mice Mammals><Modern Man><Motor Cell><Motor Neurons><Murine><Mus><Mutation><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurons><Paralysis Agitans><Parkinson><Parkinson Disease><Pathogenesis><Poly Q><Primary Parkinsonism><Proteins><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Seq><RNA Splicing><RNA sequencing><RNAseq><Research><Research Grants><Research Project Grants><Research Projects><Risk><Role><SCA2 protein><Single cell seq><Spinal Cord><Splicing><TAR DNA binding protein 43 kDa pathology><TAR DNA binding protein 43 pathology><TAR DNA binding protein of 43 proteinopathy><TAR DNA-binding protein 43><TDP-43><TDP43><TDP43 associated neurodegeneration><TDP43 associated neurodegenerative disease><TDP43 associated pathologies><TDP43 induced neurodegeneration><TDP43 neurodegeneration><TDP43 neurodegenerative disease><TDP43 neuropathology><TDP43 pathogenesis><TDP43 pathology><TDP43 proteinopathy><TDP43 related neurodegeneration><TDP43 related pathology><Technology><Testing><Therapeutic><Time><Trans active response DNA binding protein 43 pathology><Trans active response DNA binding protein of 43 kDa proteinopathy><Transgenic Mice><Translating><Variant><Variation><adulthood><amyotrophic lateral sclerosis with frontotemporal dementia><amyotrophic lateral sclerosis/FTLD><amyotrophic lateral sclerosis/frontotemporal dementia><amyotrophic lateral sclerosis/ftd><ataxin-2><biologic><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><disease risk><disorder risk><experiment><experimental research><experimental study><experiments><flexibility><flexible><frontotemporal dementia-amyotrophic lateral sclerosis><frontotemporal lobar dementia amyotrophic lateral sclerosis><genetic risk factor><genome mutation><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><in vivo><inherited factor><innovate><innovation><innovative><insight><motoneuron><motor neuron degeneration><mouse model><murine model><neurodegenerative illness><neuronal><new drug treatments><new drugs><new marker><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation><next generation therapeutics><novel><novel biomarker><novel drug treatments><novel drugs><novel marker><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><polyQ><polyglutamine><pre-clinical study><preclinical study><programs><protein TDP-43><protein TDP43><single cell next generation sequencing><single cell sequencing><skeletal><small molecule><social role><spinocerebellar ataxia type 2 gene product><success><therapeutic target><trans active response DNA binding protein 43 kDa pathology><trans active response DNA binding protein 43 proteinopathy><transcriptome sequencing><transcriptomic sequencing><transcriptomics><whole genome association analysis><whole genome association study><yeast genetics>
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Harold A Chapman

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100
Likely hiring
Large award
Active award
$1,097,760
FY 2026

Project Title

Program to block age-related pulmonary fibrosis and restore lung regeneration

Grant Number:

1R35HL183538-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

12/31/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT In the US alone ~200,000 patients present yearly with Idiopathic Pulmonary Fibrosis (IPF), a relentlessly progressive disorder with average survival of 3-5 years that is strongly linked to aging. No FDA approved drug improves lung function or well-being, underscoring the medical need for ne...

Research Terms

<Age><Aging><Alveolar><Attenuated><Basal Cell><Belief><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Line><CellLine><Cells><Characteristics><Clinic><Cytology and Pathology><Cytopathology><Data><Development><Disease><Disorder><Elderly><Elements><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epigenetic age><Epithelial Cells><Epithelium><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fibrosing Alveolitis><Fibrosis><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Gene Transcription><Genes><Genetic Transcription><HIF 1 alpha><HIF-1alpha><HIF1-Alpha><HIF1A><HIF1A gene><HIF1α><Human><Impairment><Inflammation Mediators><Injury><Link><Lung><Lung Alveolar Epithelia><Lung Respiratory System><Lung Tissue Fibrosis><Lung tissue regeneration><MOP1><Medical><Modern Man><Morbidity><Outcome><Patients><Personal Satisfaction><Pulmonary Fibrosis><RNA Expression><Regulation><Research><Respiratory Bronchiole><Risk><Self-Help Groups><Strains Cell Lines><Stress><Structure><Structure of respiratory bronchiole><Support Groups><Therapeutic><Transcription><Type II Pneumocyte><Work><advanced age><age associated><age correlated><age dependent><age linked><age related><age specific><aged><ages><alveolar epithelium><alveolar type II cell><attenuate><attenuates><cellular differentiation><cultured cell line><developmental><diffuse interstitial pulmonary fibrosis><epigenetically><fibrosis in the lung><fibrotic lung disease><fibrotic pulmonary disease><geriatric><iPS><iPSC><iPSCs><idiopathic pulmonary fibrosis><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inflammatory mediator><injuries><lung fibrosis><lung function><lung regeneration><mRNA Expression><mortality><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><programs><promoter><promotor><pulmonary function><pulmonary regeneration><self help organization><senior citizen><small molecule><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><transdifferentiation><well-being><wellbeing>
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PETER M GLAZER

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 66/100
Likely hiring
Large award
Active award
$1,006,750
FY 2026

Project Title

Targeting DNA Repair for Cancer Therapy.

Grant Number:

5R35CA197574-09

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

1/31/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

This R35 renewal application seeks to identify and exploit tumor-specific vulnerabilities based on DNA repair deficiencies and to develop novel therapeutic strategies that specifically target tumors. In the recent funding period, we discovered that elevated levels of the oncometabolites 2-hydroxyglu...

Research Terms

<(S)-Malate hydro-lyase><Acidity><Animals><Antibodies><Antigens><Basic Research><Basic Science><Bi-specific antibodies><Bifunctional Antibodies><Binding><Bispecific Antibodies><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas9 screen><Cancer Treatment><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chromatin><Clinic><Clinical Trials><DNA><DNA Damage Repair><DNA Double Strand Break><DNA Repair><DNA Repair Deficiency><DNA Repair Disorder><DNA Repair Inhibition><DNA analysis><DNA mutation><DNA- PKcs protein><DNA-Activated Protein Kinase Catalytic Subunit><DNA-PK><DNA-activated protein kinase><DNA-dependent protein kinase><DNA-dependent protein serine-threonine kinase><Data><Deoxyribonucleic Acid><Drug Screening><Exatecan><Fumarase><Fumarate Hydratase><Fumarate Reductase><Fumarates><Funding><Funding Mechanisms><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Human><Hyper-Radiosensitivity Of Murine SCID Mutation, Complementing 1><Intracellular Communication and Signaling><Isocitrate Dehydrogenase><Link><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Metabolic><Metabolic Protein Degradation><Modern Man><Molecular Interaction><Mutation><Nature><Normal Tissue><Normal tissue morphology><PARP Inhibitor><PARP-1 inhibitor><PARPi><Pathway interactions><Penetration><Peptide-based drug><Peptides><Poly(ADP-ribose) Polymerase Inhibitor><Poly(ADP-ribose) polymerase 1 inhibitor><Property><Protein Cleavage><Protein Turnover><Proteins><Proteolysis><Publishing><RNA Seq><RNA sequencing><RNAseq><Radiation Sensitizers><Radiation-Sensitizing Agents><Radiation-Sensitizing Drugs><Radiosensitization><Radiosensitizing Agents><Radiosensitizing Drugs><Radiotherapy sensitizer><Regulation><Regulatory Protein Degradation><Resistance><SCID protein><Signal Transduction><Signal Transduction Systems><Signaling><Succinate Dehydrogenase><Succinates><Succinic Dehydrogenase><Succinic Oxidase><Testing><Therapeutic Agents><Tissues><Toxic effect><Toxicities><Translational Research><Translational Science><Unscheduled DNA Synthesis><Variant><Variation><Work><XRCC7 protein><analyze DNA><anti-cancer therapy><arm><biological signal transduction><bsAb><cancer therapy><cancer-directed therapy><chemo-/radio-sensitization><clinical translation><clinically translatable><clustered regularly interspaced short palindromic repeats screen><fumarate hydrogenase><genome mutation><immunogen><malignancy><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><p460 protein><pathway><peptide drug><phase 1 trial><phase I trial><pre-clinical><preclinical><protein degradation><radiation sensitization><radio-/chemo-sensitization><radio-sensitization><radiosensitizer><radiotherapy sensitization><repair><repaired><resistance mechanism><resistant><resistant mechanism><small molecule><therapeutic peptide><transcriptome sequencing><transcriptomic sequencing><translation research><translational investigation><translational medicine><tumor>
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Rachelle L Crescenzi

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$950,550
FY 2026

Project Title

Visualizing Sodium in Lymphatic Disease: a Translational Path

Grant Number:

1R35HL184172-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

2/28/2033

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT The long-term goal of this research program is to reduce lymphatic disease burden through translational magnetic resonance imaging (MRI). We have developed a noninvasive multi-nuclear 23Na/1H MRI approach to visualize the lymphatic system together with sodium and adipose tissue storage in h...

Research Terms

<Adipose tissue><Basic Research><Basic Science><Body Tissues><Clinical><Clinical Trials><Diagnosis><Disease><Disease Progression><Disorder><Fatty Tissue><Goals><Human><Image><Investigation><Leg><Lipedema><Lymph System><Lymphatic><Lymphatic Diseases><Lymphatic Network><Lymphatic System><Lymphatic System Reticuloendothelial System><Lymphedema><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Microsurgery><Modern Man><NMR Imaging><NMR Tomography><Na element><Nuclear><Nuclear Magnetic Resonance Imaging><Outcome Measure><Patients><Physiology><Research><Sodium><Technology><Time><Tissues><Translational Research><Translational Science><Translations><Visualization><Zeugmatography><adipose><arm><burden of disease><burden of illness><design><designing><diagnostic approach><diagnostic strategy><disease burden><image translation><imaging><imaging biomarker><imaging marker><imaging-based biological marker><imaging-based biomarker><imaging-based marker><lymph edema><lymphatic disorder><lymphatic edema><measurable outcome><new diagnostics><next generation diagnostics><novel diagnostics><outcome measurement><programs><repair><repaired><research study><response><soft tissue><tech development><technology development><translation><translation research><translational investigation><white adipose tissue><yellow adipose tissue>
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Adam Carl Straub

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$929,138
FY 2026

Project Title

Basic and Translational Studies in Redox Regulation of Cardiovascular Physiology and Disease

Grant Number:

5R35HL161177-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Our research program seeks to elucidate the chemistry, biology and translational impact of “redox switches” in the cardiovascular system. Our work has revealed that cytochrome b5 reductase 3 (CYB5R3) operates as a critical redox switch in the cardiovascular system by reducing substrates suc...

Research Terms

<Binding><Biology><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chemistry><Client><Coenzyme Q><Coupled><Cytochrome-B(5) Reductase><Data Set><Dehydrogenases><Disease><Disorder><Drugs><Endogenous Nitrate Vasodilator><Endothelium><Endothelium-Derived Nitric Oxide><Enzyme Gene><Enzymes><Equilibrium><Family><Family member><Ferroprotoporphyrin><Funding><Gene Modified><Gene variant><Goals><Hb SS disease><HbSS disease><Health><Heart Muscle Cells><Heart Vascular><Heart failure><Heart myocyte><Heme><Hemi-Myeloperoxidase><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hypertension><Intracellular Communication and Signaling><Involuntary Muscle><Knock-out><Knockout><Knowledge><Medication><Molecular Interaction><Mononitrogen Monoxide><Myeloperoxidase><NADH-Cytochrome B5 Reductase><NHLBI><National Heart, Lung, and Blood Institute><Nitric Oxide><Nitrogen><Nitrogen Monoxide><Nitrogen Protoxide><O element><O2 element><Oxidation-Reduction><Oxidoreductase><Oxidoreductase Gene><Oxygen><Participant><Peroxidases><Persons><Pharmaceutical Preparations><Physiologic><Physiological><Proteins><Protoheme><Publishing><Redox><Reductases><Regulation><Reporting><Research><Research Proposals><Role><Sickle Cell Anemia><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Smooth Muscle><Soy Beans><Soybeans><Testing><Therapeutic Studies><Therapy Research><Ubiquinone><Variant><Variation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Work><allelic variant><balance><balance function><biological signal transduction><cardiac failure><cardiomyocyte><cardiovascular disorder><cardiovascular function><cardiovascular health><cell type><circulatory system><cytochrome b5 reductase><drug/agent><endothelial cell derived relaxing factor><ferroheme><gene modification><genetic variant><genetically modified><genomic variant><high blood pressure><human data><human disease><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><innovate><innovation><innovative><insight><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oxidation reduction reaction><programs><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><small molecule><social role><translational impact><translational study>
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David D GINTY

HARVARD MEDICAL SCHOOL, BOSTON, MA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$915,281
FY 2026

Project Title

Elucidating Cutaneous Mechanosensory Circuits, from Development to Disease

Grant Number:

5R35NS132196-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

11/30/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Our relationship with the physical world is rich, complex, and essential for life. How does the nervous system encode component dimensions of touch –pressure, texture, vibratory frequency, adhesiveness, wetness, compliance– and superimpose these with respect to location, direction, and speed of move...

Research Terms

<Adhesiveness><Afferent Neurons><Anatomic Sites><Anatomic structures><Anatomy><Behavioral><Cellular Mechanotransduction><Chemicals><Collaborations><Complex><Creativeness><Cutaneous><Development><Dimensions><Disease><Disorder><Frequencies><Future><Genetic><Goals><Gustation><Health><Hearing><Investigation><Investigators><Laboratories><Life><Location><Logic><Mechanical Signal Transduction><Mechanoreceptors><Mechanosensory Transduction><Mediating><Mentors><Molecular><Movement><Nerve Cells><Nerve Unit><Nervous System><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Body System><Neurologic Disorders><Neurologic Organ System><Neurological Disorders><Neurons><Olfaction><Pathway interactions><Physiologic><Physiological><Property><Research Personnel><Researchers><Sensory Neurons><Sight><Skin><Smell><Smell Perception><Speed><Stimulus><System><Systems Development><Tactile><Taste><Taste Perception><Texture><Touch><Touch sensation><Training><Vision><Work><body movement><brain circuitry><creativity><developmental><dorsal column><gustatory perception><gustatory processing><gustatory response><mechanosensing><mechanotransduction><mouse genetics><neural><neurological disease><neuron development><neuronal><neuronal circuit><neuronal circuitry><neuronal development><odor perception><olfactory perception><pathway><posterior column><pressure><somatosensory><tactile sensation><taste processing><taste response><tool><visual function>
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Li Qian

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$909,501
FY 2026

Project Title

Altering Cardiac Cell Fate for Heart Repair

Grant Number:

5R35HL155656-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/13/2021

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Direct cardiac reprogramming holds great promise as a novel therapy for heart failure, a common and morbid disease that is usually caused by irreversible loss of massive functional cardiomyocytes. By leveraging the knowledge in developmental and stem cell biology gained during my PhD and po...

Research Terms

<Acute myocardial infarct><Acute myocardial infarction><Basal Transcription Factor><Basal transcription factor genes><Body Tissues><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular Physiologic Processes><Cardiovascular Physiological Process><Cell Body><Cells><Cicatrix><Developmental Cell Biology><Disease><Disorder><Doctor of Philosophy><Fibroblasts><Funding><GATA binding protein 4><GATA4><GATA4 gene><GATA4 transcription factor><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Transcription><Grant><Heart><Heart Diseases><Heart Injuries><Heart Muscle Cells><Heart failure><Heart myocyte><Human><Impairment><In vivo analysis><Induced Cardiomyocytes><Knowledge><Laboratories><Math Models><Mechanics><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Morbidity><Murine><Mus><Myocardium><NHLBI><National Heart, Lung, and Blood Institute><Natural regeneration><Pathologic Processes><Pathological Processes><Patients><Ph.D.><PhD><Post-Transcriptional Control><Post-Transcriptional Regulation><Postdoc><Postdoctoral Fellow><Pump><RNA Expression><Regeneration><Research Associate><Scars><System><Time><Tissues><Training><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><cardiac failure><cardiac injury><cardiac muscle><cardiac repair><cardiomyocyte><clinical applicability><clinical application><epigenetic regulation><functional improvement><heart disorder><heart muscle><heart repair><icardiomyocytes><improve function><improved><improved functional outcomes><in vivo><in vivo evaluation><in vivo testing><induced cardiac myocytes><injury response><insight><mathematic model><mathematical model><mathematical modeling><mechanic><mechanical><mortality><multiomics><multiple omics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><panomics><post-doc><post-doctoral><post-doctoral trainee><post-transcriptional gene regulation><progenitor biology><progenitor cell biology><programs><public health relevance><regenerate><regeneration potential><regenerative potential><research associates><response to injury><stem and progenitor biology><stem cell biology><transcription factor>
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IRFAN RAHMAN

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$906,000
FY 2026

Project Title

LUNG CELLULAR SENESCENCE AND MOLECULAR CLOCK REV-ERBalpha BY ENVIRONMENTAL TOBACCO SMOKE

Grant Number:

1R35ES035011-01A1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/19/2026

End Date:

1/31/2034

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Tobacco/cigarette smoke (CS) including environmental tobacco smoke (ETS) exposure leads toxicological effects on the lungs associated with injury and inflammation in airway disorders, such as Chronic Obstructive Pulmonary Disease (COPD). COPD is the third leading cause of chronic morbidity a...

Research Terms

<3-D><3-Dimensional><3D><Adverse effects><Agonist><Airway Disease><Attenuated><COPD><Caliber><Cell Aging><Cell Body><Cell Senescence><Cell Senescence Induction><Cells><Cellular Aging><Cellular Senescence><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Collaborations><Complex><Development><Disease><Disorder><Drug Therapy><Dysfunction><Environmental Toxin><Functional disorder><Genes><Goals><HDAC><HDAC Proteins><Health><Histone Deacetylase><Human><Inflammaging><Inflammation><Inflammatory><Inhalation Toxicology><Injury><Lung><Lung Diseases><Lung Respiratory System><Mediating><Mediator><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Morbidity><Nuclear><Nuclear Receptor Gene><Outcome><Passive Smoke Exposure><Pathogenesis><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiopathology><Pulmonary Diseases><Pulmonary Disorder><Replicative Senescence><Research><Resolution><Role><Science><Seminal><Sight><Smoker><Stress><Tobacco><Tobacco smoke><Toxic Environmental Agents><Toxic Environmental Substances><Toxic effect><Toxicities><Toxicology><Training><United States><Vision><age-related inflammation><aging associated inflammation><attenuate><attenuates><attenuation><cellular aging induction><cellular senescence induction><chronic obstructive pulmonary disorder><cigarette smoke><co-repressor><corepressor><developmental><disease of the lung><disorder of the lung><drug intervention><drug treatment><environmental tobacco smoke><environmental tobacco smoke exposure><environmental toxicant><exposure to ETS><exposure to SHS><exposure to environmental tobacco smoke><exposure to secondhand smoke><exposure to tobacco smoke><gene co-repressor><gene corepressor><genetic co-repressor><genetic corepressor><improved><inflamm-ageing><inflamm-aging><inflammation associated with aging><inhibitor><injuries><life span><lifespan><lung disorder><molecular clock><molecular profile><molecular signature><mortality><non-smoker><nonsmoker><pathophysiology><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><premature lung aging><programs><pulmonary><replicative aging><resolutions><response><restoration><second hand smoke exposure><second-hand smoke><second-hand tobacco smoke><secondhand smoke><secondhand smoke exposure><secondhand tobacco smoke><secondhand tobacco smoke exposure><senescence><senescence induction><senescent><senescent cell><senolytics><senomorphic><senostatic><social role><three dimensional><translational opportunities><translational potential><visual function>
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SANTHI K GANESH

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$903,380
FY 2026

Project Title

Genomic and Functional Studies of Dysplasia-Associated Arterial Diseases

Grant Number:

5R35HL161016-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project summary Fibromuscular dysplasia (FMD) is a non-atherosclerotic, systemic arteriopathy with excess burden on women. FMD may have varying manifestations, including hypertension, stroke and myocardial infarction, among others, depending on the arterial beds involved by arterial stenosis, aneury...

Research Terms

<Alleles><Allelomorphs><Aneurysm><Apoplexy><Arterial Disorder><Arteries><Arteriopathy><Beds><Biologic Factor><Biologic Models><Biological><Biological Factors><Biological Models><Blood Vessels><Brain Vascular Accident><Cardiac infarction><Cardiovascular><Cardiovascular Body System><Cardiovascular Manifestation><Cardiovascular Organ System><Cardiovascular system><Cell model><Cell-Extracellular Matrix><Cellular model><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cessation of life><Clinical><Complex><Computer Analysis><Death><Differences between sexes><Differs between sexes><Disease><Disorder><Dissection><Dysplasia><ECM><Extracellular Matrix><Fibromuscular Dysplasia><Gene variant><Generalized Growth><Genes><Genetic><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Genomics><Goals><Growth><Heart Vascular><Heritability><Heterogeneity><Hypertension><Inherited Predisposition><Inherited Susceptibility><Involuntary Muscle><Laboratories><Medial><Model System><Modeling><Molecular><Molecular Genetics><Morbidity><Myocardial Infarct><Myocardial Infarction><Outcome><Pathologic><Pathological Constriction><Phenotype><Population><Precision Health><Predisposition><Predisposition gene><Prevention><Research Resources><Resolution><Resources><Role><Sex Differences><Sexual differences><Smooth Muscle><Stenosis><Stroke><Susceptibility><Susceptibility Gene><Testing><Tissue Growth><Variant><Variation><Vascular Diseases><Vascular Disorder><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Vascular Smooth Muscle><Woman><allelic variant><arterial remodeling><artery stenosis><biobank><biologic><biological sex><biorepository><blood vessel disorder><brain attack><cardiac infarct><cerebral vascular accident><cerebrovascular accident><circulatory system><clinical diagnosis><computational analyses><computational analysis><computer analyses><coronary attack><coronary infarct><coronary infarction><disease diagnosis><dyscrasia><experiment><experimental research><experimental study><experiments><genetic approach><genetic architecture><genetic strategy><genetic variant><genetic vulnerability><genetically predisposed><genomic variant><heart attack><heart infarct><heart infarction><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><in vitro Model><in vivo><insight><mortality><mouse model><murine model><new diagnostics><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation diagnostics><novel diagnostics><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><predisposing gene><resolutions><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><stroked><strokes><susceptibility allele><susceptibility locus><susceptibility variant><unclassified variant><variant of uncertain clinical significance><variant of uncertain significance><variant of undetermined significance><variant of unknown significance><vascular><vascular dysfunction><vasculopathy>
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Bradley Joel Undem

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$893,183
FY 2026

Project Title

Neurobiology of the Bronchopulmonary System

Grant Number:

5R35HL155671-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2021

End Date:

2/28/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/ Abstract Basic and clinical research over the past decade is shedding new light on the major role played by the nervous system in respiratory pathophysiology, in particular in the “hypertussivity” associated with chronic unproductive cough, in the “airways hyperresponsiveness”” asso...

Research Terms

<21+ years old><Adult><Adult Human><Airway Disease><Airway Hyper-responsiveness><Animals><Asthma><Autacoids><Award><Basic Research><Basic Science><Biology><Bronchial Asthma><C Fiber><CNS plasticity><COPD><Chemicals><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical Research><Clinical Study><Coughing><Disease><Disorder><Dysfunction><Functional disorder><Funding><Grant><Human><Hyperactivity><Image><Infection><Inflammation Mediators><Inflammatory><Investigators><Laboratories><Life><Mentors><Methodology><Methods><Modern Man><Modernization><Nature><Nerve><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neurobiology><Neurocyte><Neurologic Body System><Neurologic Organ System><Neuronal Plasticity><Neurons><Neurosciences><Neurosciences Research><Physiopathology><Play><Pulmonary Body System><Pulmonary Organ System><Research Personnel><Researchers><Respiratory System><Respiratory Tracts><Respiratory tract structure><Role><Secondary to><Slow-Reacting Substances><Sodium Channel><Sodium Ion Channels><System><Techniques><Technology><Viral Diseases><Virus Diseases><Visceral><adulthood><afferent nerve><airway epithelium inflammation><airway hyper-reactivity><airway hyperactivity><airway hyperreactivity><airway hyperresponsiveness><airway hypersensitivity><airway inflammation><central nervous system plasticity><chronic obstructive pulmonary disorder><critical period><cytokine><imaging><inflammatory mediator><innervation><interest><nerve supply><neural plasticity><neurobiological><neuronal><neurophysiological><neurophysiology><neuroplastic><neuroplasticity><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathophysiology><respiratory><respiratory inflammation><respiratory tract inflammation><sensory nerve><slow reacting substance><social role><user-friendly><viral infection><virus infection><virus-induced disease><voltage>
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Nigel Mackman

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$886,350
FY 2026

Project Title

Tissue factor-dependent coagulation in thrombosis and immune responses

Grant Number:

5R35HL155657-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2021

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Tissue factor (TF) is a transmembrane protein that functions as a high-affinity receptor for factor (F)VII and FVIIa. The TF-FVIIa complex is the primary initiator of coagulation and plays an essential role in hemostasis. However, aberrant TF expression underlies most forms of thrombosis. TF express...

Research Terms

<ASCVD><Aberrant Tissue><Affinity><Assay><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Bacterial Infections><Bioassay><Biological Assay><Biological Markers><Blood Coagulation Factor III><Blood Plasma><CD142 Antigens><CF2R><Cancer Patient><Cancers><Cell Communication and Signaling><Cell Signaling><Choristoma><Clinical><Clotting><Coagulation><Coagulation Factor III><Coagulation Process><Coagulin><Complex><Consumption Coagulopathy><Coxsackie Viruses><Coxsackievirus><Disseminated Intravascular Coagulation><Ectopic Tissue><Endopeptidase-Activated Receptors><Endotoxemia><Esteroproteases><F2R><F2R gene><Factor III><Funding><Funding Mechanisms><Generalized Growth><Generations><Glomerular Procoagulant Activity><Goals><Grant><Growth><H1N1><H1N1 Virus><Health><Heart><Hemostasis><Hemostatic function><Heterotopic Tissue><Human><Immune response><Infection><Influenza A><Influenza A Virus, H1N1 Subtype><Influenza A virus><Influenza Viruses Type A><Influenzavirus A><Innate Immune Response><Integral Membrane Protein><Intracellular Communication and Signaling><Intrinsic Membrane Protein><Ischemia-Reperfusion Injury><Knowledge><Lung><Lung Respiratory System><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant neoplasm of pancreas><Measures><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Myocarditis><NHLBI><National Heart, Lung, and Blood Institute><Orthomyxovirus Type A><PAR1><Pancreas Cancer><Pancreas Neoplasms><Pancreas Tumor><Pancreatic Cancer><Pancreatic Tumor><Pathologic><Pathway interactions><Peptidases><Peptide Hydrolases><Phlebothrombosis><Plasma><Plasma Serum><Play><Protease Gene><Protease-Activated Receptors><Proteases><Proteinase-Activated Receptors><Proteinases><Proteolytic Enzymes><Proteomics><Prothrombinase><Receptor Protein><Reperfusion Damage><Reperfusion Injury><Reticuloendothelial System, Serum, Plasma><Risk><Risk Marker><Role><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Source><System><Thrombase><Thrombin><Thromboplastin><Thrombosis><Time><Tissue Factor><Tissue Factor Procoagulant><Tissue Growth><Tissue Thromboplastin><Transmembrane Protein><Transmembrane Protein Gene><Tumor-Derived><Type A Influenza><Urothromboplastin><Venous Thrombosis><Viral><Viral Diseases><Virus Diseases><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><bacteria infection><bacterial disease><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker identification><cardiac inflammation><enhancing factor><extracellular vesicles><fibrinogenase><high reward><high risk><host response><human model><identification of biomarkers><identification of new biomarkers><immune system response><immunoresponse><improved><influenza A pneumonia><malignancy><marker identification><model of human><mouse model><murine model><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new technology><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel technologies><novel therapeutics><novel therapy><ontogeny><pancreatic cancer patients><pancreatic malignancy><pancreatic neoplasia><pancreatic neoplasm><pathogen><pathway><patients with pancreatic cancer><prevent><preventing><protein function><receptor><response><risk predictor><risk predictors><social role><thrombotic><thrombotic disease><thrombotic disorder><tumor><tumor growth><venous thromboembolism><viral infection><virus infection><virus-induced disease>
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SIDNEY Waldo WHITEHEART

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$884,606
FY 2026

Project Title

Platelet Exocytosis and Endocytosis in Thrombosis and Immunity

Grant Number:

5R35HL150818-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2020

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Surprisingly, platelets are capable of bidirectional interactions with their microenvironment through basic cellular processes that are largely unexplored. In this R35 proposal, we expand on our active research themes: one unraveling the mechanistic role of exocytosis in hemostasis and the ...

Research Terms

<AIDS><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immunodeficiency Syndrome><Address><Advanced HIV><Affect><Area><Blood Platelets><Blood Vessels><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cellular Function><Cellular Physiology><Cellular Process><Cellular biology><Cessation of life><Chronic><Clotting><Coagulation><Coagulation Process><Cytoplasmic Granules><Data><Death><Detection><Endocytosis><Exocytosis><Generalized Growth><Growth><HIV-1><HIV-I><HIV1><Hemostasis><Hemostatic function><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human immunodeficiency virus 1><Immune response><Immune system><Immunity><Innate Immune Response><Innate Immunity><Intracellular Communication and Signaling><Knowledge><Link><Marrow platelet><Membrane><Modeling><Molecular><Mouse Strains><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Pathogen detection><Pathway interactions><Physiologic><Physiological><Platelets><Process><Publications><Reagent><Research><Risk><Role><Scientific Publication><Severe HIV Disease><Signal Transduction><Signal Transduction Systems><Signaling><Sorting><Subcellular Process><Technology><Therapeutic><Thrombocytes><Thrombosis><Thrombus><Tissue Growth><Transgenic Mice><Viremia><Virus><Work><biological signal transduction><cell biology><granule><holistic approach><host response><human disease><immune system response><immunoresponse><innovate><innovation><innovative><insight><membrane structure><ontogeny><pathogen><pathway><programs><social role><thrombotic disease><thrombotic disorder><tool><trafficking><vascular><viraemia><viral sepsis><virusemia>
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Yishi Jin

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$862,680
FY 2026

Project Title

Molecular genetics of axon and synapse development and maintenance

Grant Number:

5R35NS127314-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

4/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The goals of my research program are to elucidate fundamental mechanisms underlying synapse and axon development and maintenance. We take multi-tiered approaches to investigate these processes, primarily using C. elegans because this animal model is well suited for in vivo imaging wi...

Research Terms

<21+ years old><Adolescent><Adolescent Youth><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Animals><Axon><Brain><Brain Nervous System><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Calcium><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cellular Function><Cellular Physiology><Cellular Process><Coupled><DNA mutation><Development><Dissection><Dysfunction><Encephalon><Ensure><Event><Functional disorder><GeneHomolog><Generalized Growth><Genetic Change><Genetic Models><Genetic Screening><Genetic defect><Genetic mutation><Goals><Growth><Homolog><Homologous Gene><Homologue><Human><In vivo analysis><Intracellular Communication and Signaling><Intracellular Structure><Knowledge><Maintenance><Membrane><Mice><Mice Mammals><Modern Man><Molecular Dynamics Simulation><Molecular Genetics><Motor><Murine><Mus><Mutation><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Body System><Neurologic Disorders><Neurologic Organ System><Neurological Disorders><Neuron Degeneration><Neurons><Neurophysiology - biologic function><Organelles><Organism><Pathologic Processes><Pathological Processes><Pathway interactions><Pattern><Phase><Physiologic><Physiological><Physiopathology><Play><Process><Property><Proteins><Repression><Research><Resolution><Role><Signal Transduction><Signal Transduction Systems><Signaling><Stereotyping><Subcellular Process><Subcellular structure><Synapses><Synaptic><Tissue Growth><Transcriptional Control><Transcriptional Regulation><Visualization><adulthood><axon damage><axon injury><axon regeneration><axonal damage><axonal injury><axonal regeneration><biological adaptation to stress><biological signal transduction><developmental><discover genes><experiment><experimental research><experimental study><experiments><gene discovery><genome mutation><holistic approach><imaging in vivo><in vivo evaluation><in vivo imaging><in vivo testing><innovative technologies><insight><interest><juvenile><juvenile human><living system><membrane structure><model of animal><molecular dynamics><neural circuit><neural circuitry><neural degeneration><neural function><neurocircuitry><neurodegeneration><neurodegenerative><neurological degeneration><neurological disease><neuronal><neuronal degeneration><ontogeny><pathophysiology><pathway><programs><reactioncrisis><regeneration model><regenerative model><resolutions><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stress response><stressreaction><synapse><synapse formation><synaptic circuit><synaptic circuitry><synaptogenesis>
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Nazish Sayed

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$770,000
FY 2026

Project Title

Unraveling Endothelial-CardiomyocyteCrosstalk in Cardiomyopathy: An Integrated Multimodal Approach

Grant Number:

1R35HL183578-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2033

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Cardiomyopathy is known to affect the myocardium and is associated with either mechanical and/or electrical dysfunction that can lead to ventricular hypertrophy or dilatation. These cardiomyopathies can affect people of all ages and can be either inherited or acquired, where...

Research Terms

<Affect><Age><Animal Model><Animal Models and Related Studies><Attention><Biomedical Engineering><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiomyopathies><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Complex><DNA mutation><Data><Development><Diabetes Mellitus><Dilatation><Dilatation - action><Drugs><Dysfunction><Endothelial Cells><Endothelium><Exposure to><Functional disorder><Genes><Genetic Change><Genetic defect><Genetic mutation><Goals><Health><Heart Diseases><Heart Muscle Cells><Heart Vascular><Heart failure><Heart myocyte><Hereditary><Inherited><Intracellular Communication and Signaling><Investigators><Knowledge><Maps><Mechanics><Medication><Methods><Molecular><Morbidity><Mutation><Myocardial Diseases><Myocardial Disorder><Myocardial depression><Myocardial dysfunction><Myocardiopathies><Myocardium><NGS Method><NGS system><Organ><Pathogenesis><Patients><Persons><Pharmaceutical Preparations><Physiopathology><Play><Research><Research Personnel><Researchers><Role><Signal Transduction><Signal Transduction Systems><Signaling><United States><Work><ages><bio-engineered><bio-engineers><bioengineering><biological engineering><biological signal transduction><cardiac dysfunction><cardiac failure><cardiac function><cardiac muscle><cardiomyocyte><chemotherapeutic agent><chemotherapeutic compounds><chemotherapeutic drugs><chemotherapeutic medications><chemotherapy><circulatory system><co-morbid><co-morbidity><comorbidity><developmental><diabetes><drug/agent><familial cardiomyopathy><function of the heart><genetic cardiomyopathy><genome mutation><heart disorder><heart dysfunction><heart function><heart muscle><hereditary cardiomyopathy><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><improved><induced human pluripotent stem cells><inherited cardiomyopathy><injury to the myocardium><insight><interdisciplinary approach><interest><lens><lenses><mechanic><mechanical><model of animal><mortality><multi-modality><multidisciplinary approach><multimodality><myocardial injury><myocardium disease><myocardium disorder><next gen sequencing><next generation sequencing><nextgen sequencing><paracrine><pathophysiology><programs><social role><tool><ventricular hypertrophy>
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Fadi N Salloum

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$760,725
FY 2026

Project Title

Managing Cardiac Toxicities of Cancer Therapy

Grant Number:

5R35HL155651-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2021

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary This R35 application proposes to capitalize on previous work produced by the PI over the past 11 years and to further serve as a strong foundation for interrogating the role of sterile cardiac inflammation (inflammasomes) in promoting the progression of heart failure caused by chemot...

Research Terms

<14-Hydroxydaunomycin><Acute myocardial infarct><Acute myocardial infarction><Adriamycine><Attenuated><Blood><Blood Reticuloendothelial System><CFL2 gene product><Cancer Survivor><Cancer Treatment><Cancers><Cardiac><Cardiac Toxicity><Cardiac infarction><Cardiomyopathies><Cardiotoxic><Cardiotoxicity><Cell Communication and Signaling><Cell Death><Cell Signaling><Cellular Stress><Cellular Stress Response><Data><Development><Doxorubicin><Doxorubicina><Early-Stage Clinical Trials><Endogenous Nitrate Vasodilator><Endothelium-Derived Nitric Oxide><Exposure to><Failure><Fibrosis><Foundations><Goals><Heart><Heart failure><Hydrogen Sulfide><Hydroxyl Daunorubicin><Hydroxyldaunorubicin><Inflammasome><Inflammation><Inflammatory><Injury><Intracellular Communication and Signaling><Investigation><Ischemia><Ischemic Heart><Ischemic Heart Disease><Ischemic myocardium><Knowledge><Literature><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mediating><Mice><Mice Mammals><Modality><Mononitrogen Monoxide><Murine><Mus><Myocardial Diseases><Myocardial Disorder><Myocardial Infarct><Myocardial Infarction><Myocardial Ischemia><Myocardiopathies><Myocarditis><Nitric Oxide><Nitrogen Monoxide><Nitrogen Protoxide><Oncology><Oncology Cancer><Oral><Oxidative Stress><Patients><Phase 1 Clinical Trials><Phase I Clinical Trials><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Pre-Clinical Model><Preclinical Models><Preventive><Process><Production><Protein Modification><Proteins><Role><Secondary to><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Sterility><Stress><Structural Protein><Therapeutic><Toxic effect><Toxicities><Work><anti-cancer therapy><attenuate><attenuates><biological signal transduction><cancer therapy><cancer-directed therapy><cardiac failure><cardiac function><cardiac infarct><cardiac inflammation><cardiac ischemia><cell stress><cell type><chemotherapy><cofilin><cofilin 2><coronary attack><coronary infarct><coronary infarction><coronary ischemia><design><designing><developmental><endothelial cell derived relaxing factor><function of the heart><heart attack><heart function><heart infarct><heart infarction><heart ischemia><injuries><injury to the myocardium><interstitial><ischemia injury><ischemic injury><malignancy><mitochondrial dysfunction><myocardial injury><myocardial ischemia/hypoxia><myocardium disease><myocardium disorder><myocardium ischemia><necrocytosis><neoplasm/cancer><novel><oxidation><phase I protocol><preservation><prevent><preventing><programs><social role><sterile>
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ANTHONY ROSENZWEIG

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$757,897
FY 2026

Project Title

Understanding the Cardiac Benefits of Exercise at the Cellular and Molecular Level

Grant Number:

5R35HL155318-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2021

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Heart failure (HF) is a growing cause of morbidity and mortality. Despite the best available treatments, prognosis remains poor for many HF patients underscoring the unmet clinical need for new HF therapies. This Outstanding Investigator Award application is inspired by the...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Animal Model><Animal Models and Related Studies><Assay><Award><Bioassay><Bioinformatics><Biological><Biological Assay><Brachydanio rerio><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular Diseases><Cell Body><Cell Culture Techniques><Cell Lineage><Cells><Chromatin><Clinical><Danio rerio><Environment><Exercise><Fibrosis><Gene Expression><Generations><Heart><Heart Diseases><Heart Hypertrophy><Heart Muscle Cells><Heart failure><Heart myocyte><Hypertrophy><In Vitro><Inflammation><Investigators><Label><Mediating><Modeling><Molecular><Morbidity><NHLBI><National Heart, Lung, and Blood Institute><Nature><Pathologic><Pathway interactions><Patients><Pre-Clinical Model><Preclinical Models><Process><Prognosis><Proliferating><Public Health><RNA Seq><RNA sequencing><RNAseq><Research><Research Personnel><Researchers><Science><Single-Nucleus Sequencing><Stress><Testing><Therapeutic><Time><Transposase><Treatment Failure><Work><Zebra Danio><Zebra Fish><Zebrafish><adulthood><biologic><cardiac failure><cardiac hypertrophy><cardiomyocyte><cardiovascular disorder><cell culture><cell cultures><cell type><flexibility><flexible><gain of function><heart cell><heart disorder><in vivo><insight><loss of function><meeting><meetings><model of animal><mortality><mouse model><murine model><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><pathway><permissiveness><pig model><piglet model><porcine model><pre-clinical><preclinical><prevent><preventing><programs><response><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><swine model><therapy failure><tool><transcriptome sequencing><transcriptomic sequencing><translational opportunities><translational potential>
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Anuradha Ray

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$725,426
FY 2026

Project Title

Dysregulated Immunometabolism and Premature Senescence in Corticosteroid-Refractory Severe Asthma

Grant Number:

5R35HL166219-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Our laboratory has been engaged in elucidating mechanisms of asthma pathogenesis for over two decades. These efforts resulted in the discovery of GATA-3 as the key molecular regulator of development of Th2 cells that promote allergic airway disease. Since our initial discovery, GATA-3 was successful...

Research Terms

<0-11 years old><21+ years old><Address><Adrenal Cortex Hormones><Adult><Adult Human><Allergens><Asthma><Belief><Bronchial Asthma><Bronchioalveolar Lavage><Bronchoalveolar Lavage><Bronchoalveolar Lavage Fluid><Bronchopulmonary Lavage><COPD><Cell Aging><Cell Body><Cell Senescence><Cell Senescence Induction><Cells><Cellular Aging><Cellular Senescence><Child><Child Youth><Children (0-21)><Chronic Disease><Chronic Illness><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Chronic lung disease><Clinical><Corticoids><Corticosteroids><DNA Molecular Biology><Development><Dose><Fibrosing Alveolitis><Funding><Generations><Glucocorticoid Receptor><Goals><Human><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune Interferon><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immunes><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunology><Inflammaging><Inflammatory><Inhalation><Inhaling><Interferon Gamma><Interferon Type II><Intermediary Metabolism><Laboratories><Lipids><Literature><Lung><Lung Diseases><Lung Lavage><Lung Respiratory System><Metabolic Processes><Metabolism><Modern Man><Molecular><Molecular Biology><Pathogenesis><Patients><Phenotype><Premature Aging><Premature aging syndrome><Production><Pulmonary Diseases><Pulmonary Disorder><Refractory><Replicative Senescence><Research><STAT1><STAT1 gene><STAT91><Scientist><Side><Stress><T-Cells><T-Lymphocyte><Th-2 Cell><Th2 Cells><Therapeutic><Therapeutic Intervention><Training><Type 2 Helper Cell><adulthood><age-related inflammation><aging associated inflammation><allergic airway disease><asthma patient><asthmatic patient><bronchiolar alveolar lavage><bronchopulmonary lavage therapy><cellular aging induction><cellular senescence induction><chronic disorder><chronic obstructive pulmonary disorder><chronic pulmonary disease><developmental><diffuse interstitial pulmonary fibrosis><disease heterogeneity><disease of the lung><disorder of the lung><flexibility><flexible><high dimensionality><host response><idiopathic pulmonary fibrosis><immune system response><immunoresponse><improved><in vivo><inflamm-ageing><inflamm-aging><inflammation associated with aging><interest><intervention therapy><kids><lFN-Gamma><lung disorder><mitochondrial dysfunction><mouse model><multiomics><multiple omics><murine model><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><old age><panomics><peripheral blood><premature><prematurity><prevent><preventing><programs><replicative aging><resident memory T cell><response><response to therapy><response to treatment><senescence><senescence induction><senescent><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic response><therapy response><thymus derived lymphocyte><tissue resident memory T cell><tool><treatment response><treatment responsiveness><youngster>
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Nicholas W Lukacs

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$671,223
FY 2026

Project Title

Viral and allergen-driven immunity in chronic lung disease

Grant Number:

5R35HL150682-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2020

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Severe allergic asthmatic disease is characterized by significant airway structure changes and chronic inflammation predominated by eosinophils, mononuclear cells, and lymphocytes, and accompanied by mucus hypersecretion that depends upon the nature of the immune response. The most severe a...

Research Terms

<Address><Airway Disease><Allergens><Allergic><Area><Asthma><Autophagocytosis><Biological Response Modifiers><Biomodulators><Blood Eosinophil><Bronchial Asthma><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Chemotactic Cytokines><Chronic><Chronic Disease><Chronic Illness><Chronic lung disease><Clinical><Development><Disease><Disorder><Dysfunction><Environment><Eosinophilic Granulocyte><Eosinophilic Leukocyte><Functional disorder><Goals><Grant><Homologous Chemotactic Cytokines><Immune><Immune Cell Activation><Immune Mediators><Immune Mediators/Modulators><Immune response><Immunes><Immunity><Immunomodulation><Inflammation><Intercrines><Intermediary Metabolism><Investigation><Knowledge><Laboratories><Link><Lung><Lung Diseases><Lung Respiratory System><Lung immune response><Lymphatic cell><Lymphocyte><Lymphocytic><MGF Stem Cell Factor><Marrow Eosinophil><Mast Cell Growth Factor><Metabolic Control><Metabolic Processes><Metabolism><Mononuclear><NHLBI><National Heart, Lung, and Blood Institute><Nature><Neonatal><Phenotype><Physiopathology><Population><Process><Pulmonary Diseases><Pulmonary Disorder><Research><Role><SIS cytokines><Severity of illness><Shapes><Steel Factor><Stem Cell Factor><Steroid Resistance><Steroid Resistant><Structure><Subcellular Process><Therapeutic><Therapeutic Intervention><Training><Viral><Viral Respiratory Tract Infection><Work><asthmatic><autophagy><c-kit Ligand><cell metabolism><cellular metabaolism><chemoattractant cytokine><chemokine><chronic disorder><chronic pulmonary disease><cytokine><developmental><disease of the lung><disease severity><disorder of the lung><eosinophil><epigenetic regulation><host response><immune activation><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><insight><intervention therapy><kit Ligand><lung development><lung disorder><lung function><lung repair><lung tissue repair><lymph cell><mucus hyper-secretion><mucus hypersecretion><notch><notch protein><notch receptors><novel><pathophysiology><pulmonary><pulmonary function><pulmonary immune response><pulmonary repair><response><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><viral respiratory infection>
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Ninian J Blackburn

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$619,006
FY 2026

Project Title

Peptide Processing by Copper Enzymes

Grant Number:

2R35GM136239-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Peptide processing is a post-translational function that converts pro-peptides into their mature forms. Amidated peptides interact with GPCRs at the cell membrane leading to production of essential hormones, while NRPS or RiPPs are a major source of lead compounds for antibacterial, antivir...

Research Terms

<Anti-Bacterial Agents><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Cell membrane><Chemistry><Clinic><Complex><Copper><Coupled><Cryo-electron Microscopy><Cryoelectron Microscopy><Cu element><Cytoplasmic Membrane><Data><Dopamine-beta-monooxygenase><EPR spectroscopy><ESR Spectroscopy><Electron Cryomicroscopy><Electron Paramagnetic Resonance><Electron Spin Resonance><Electron Spin Resonance Spectroscopy><Electronics><Endocrine Gland Secretion><Enzyme Gene><Enzymes><Funding><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Homocysteine><Hormones><Hydroxylation><Lead><Mediating><Metals><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Nuclear><Ozempic><Paramagnetic Resonance><Pathway interactions><Pb element><Peptide Synthesis><Peptides><Plasma Membrane><Production><Reaction><Ribosomes><Roentgen Rays><Rybelsus><Site><Source><Suggestion><Viral Cancer><Wegovy><X-Radiation><X-Ray Radiation><X-ray><Xray><alpha-amidating enzyme AE-II><amidation><analog><anti-bacterial><anti-cancer therapeutic><conformation><conformational><conformational conversion><conformational state><conformational transition><conformationally><conformations><crosslink><cryo-EM><cryoEM><cryogenic electron microscopy><design><designing><dopamine beta hydroxylase><dopamine β-hydroxylase><electron paramagnetic resonance spectroscopy><electronic><electronic device><heavy metal Pb><heavy metal lead><pathway><peptidyl alpha-amidating monooxygenase><peptidyl-glycine alpha-amidating monooxygenase><peptidylglycine 2-hydroxylase><peptidylglycine alpha-amidating monooxygenase><peptidylglycine alpha-hydroxylating monooxygenase><peptidylglycine hydroxylase><peptidylglycine monooxygenase><plasmalemma><programs><semaglutide>
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Lu Bai

PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$583,193
FY 2026

Project Title

Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation

Grant Number:

2R35GM139654-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2021

End Date:

11/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary / Abstract The overall theme of my research program is to unravel the mechanisms underlying chromatin structure and understand its role in gene regulation. Our approach tackles this challenge on two interconnected levels: at the chromatin / nucleosome level, we investigate the mechan...

Research Terms

<3-D><3-D structure><3-Dimensional><3-dimensional structure><3C-based approach><3C-based assay><3C-based method><3C-based strategy><3C-based technique><3C-based technology><3D><3D structure><Area><Automobile Driving><Binding><Binding Sites><Budding Yeast><Cell Body><Cell Nucleus><Cells><Chemicals><Chromatin><Chromatin Structure><Chromosomal Organization><Chromosomal Structure><Chromosome Organization><Chromosome Structures><Chromosomes><Combining Site><Disease><Disorder><Endomycetales><Foundations><Gene Action Regulation><Gene Down-Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Genome><Goals><Health><Heterochromatin><Human><Image><Invaded><Link><Mammalian Cell><Methodology><Methods><Modern Man><Molecular Interaction><Nuclear><Nucleosomes><Nucleus><Oligo><Oligonucleotides><Pattern><Physical condensation><Play><Process><Reactive Site><Regulator Genes><Research><Role><Saccharomycetales><Specificity><Structure><Technology><Therapeutic Intervention><Transcription Repression><Transcriptional Control><Transcriptional Regulation><Transcriptional Regulatory Elements><Yeasts><chromatin conformation capture><chromosome capture><chromosome conformation capture><cohesin><condensation><detection method><detection procedure><detection technique><driving><gene repression><genetic trans acting element><human disease><imaging><innovate><innovation><innovative><insight><intervention therapy><oligos><programs><regulatory gene><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><three dimensional><three dimensional structure><trans acting element>
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Holger K. Eltzschig

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$551,762
FY 2026

Project Title

Targeting Hypoxia-Inducible Factors (HIFs) for Heart and Lung Disease

Grant Number:

5R35HL177402-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

12/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The current application for R35 funding is focused on targeting hypoxia-inducible factors (HIFs) for heart and lung disease. HIFs were discovered as transcription factors that are stabilized during hypoxia and promote adaptive responses. However, during inflammation or ischemia and r...

Research Terms

<ARDS><ARNTL><ARNTL gene><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Adult ARDS><Adult RDS><Adult Respiratory Distress Syndrome><Alveolar><Area><BMAL1><Basal Transcription Factor><Basal transcription factor genes><Basic Research><Basic Science><Body Tissues><Cardiac Diseases><Cardiac Disorders><Cell Communication and Signaling><Cell Signaling><Circadian Rhythms><Clinical Sciences><Complex><Cryo-electron Microscopy><Cryoelectron Microscopy><DNA><Da Nang Lung><Deoxyribonucleic Acid><Development><Electron Cryomicroscopy><Enzyme Gene><Enzymes><Funding><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Transcription><Grant><Heart Diseases><Heart Injuries><Human><Hypoxia><Hypoxia Inducible Factor><Hypoxic><Individual><Inflammation><Inflammatory><Infrastructure><Intracellular Communication and Signaling><Investigators><Ischemia><Ischemia-Reperfusion Injury><Ischemic Heart><Ischemic Heart Disease><Ischemic myocardium><Isoforms><Laboratories><Link><Lung Alveolar Epithelia><Lung Diseases><Mediating><Metabolic><Mice><Mice Mammals><MicroRNAs><Modern Man><Molecular><Murine><Mus><Myocardial Ischemia><NHLBI><National Heart, Lung, and Blood Institute><Nyctohemeral Rhythm><Oxygen Deficiency><Pathway interactions><Peptidyl Prolyl Hydroxylase><Procollagen Prolyl 4-Hydroxylase><Procollagen-Proline Dioxygenase><Proline Hydroxylase><Proline,2-Oxoglutarate 4-Dioxygenase><Prolyl 4-Hydroxylase><Prolyl Hydroxylase><Protein Isoforms><Protocollagen Prolyl Hydroxylase><Pulmonary Diseases><Pulmonary Disorder><RNA Expression><Regulation><Reperfusion Damage><Reperfusion Injury><Reperfusion Therapy><Research><Research Personnel><Research Resources><Researchers><Resistance><Resources><Role><Shock Lung><Signal Transduction><Signal Transduction Systems><Signaling><Stiff lung><Structure><Sum><Technology><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Twenty-Four Hour Rhythm><Variant><Variation><alveolar epithelium><aryl hydrocarbon receptor nuclear translocator-like><biobank><biological signal transduction><biorepository><cardiac injury><cardiac ischemia><circadian><circadian process><circadian rhythmicity><coronary ischemia><cryo-EM><cryoEM><cryogenic electron microscopy><daily biorhythm><developmental><disease of the lung><disorder of the lung><heart disorder><heart ischemia><injury to organs><injury to the myocardium><ischemia injury><ischemic injury><lung disorder><miRNA><myocardial injury><myocardial ischemia/hypoxia><myocardium ischemia><novel><organ injury><pathway><programs><reperfusion><resistant><response><social role><therapeutic target><transcription factor><translational therapeutics><translational therapy><wet lung>
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Ricardo Mallarino

PRINCETON UNIVERSITY, Princeton, NJ

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$473,550
FY 2026

Project Title

Using naturally evolved phenotypic variation to decipher the positional regulatory code of mammalian skin

Grant Number:

5R35GM133758-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/13/2019

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Changes occurring during embryogenesis are typically lethal or can lead to congenital malformations. In many cases, however, these changes can be beneficial because they can promote the origin of new traits and the evolution of adaptations. Because of this relationship between delete...

Research Terms

<African><Animals><Birth Defects><Code><Coding System><Color><Computational Biology><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Data><Development><Developmental Biology><Developmental Process><Discipline><Dorsal><Embryo Development><Embryogenesis><Embryonic Development><Evolution><Expression Signature><Funding><Gene Expression><Gene Expression Profile><Genomics><Hair Follicle><Hair follicle structure><Investigators><Laboratories><Marsupialia><Marsupials><Membrane><Metatheria><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Outcome><Pattern><Pattern Formation><Phenotype><Pigmentation><Pigmentation physiologic function><Pigments><Research><Research Personnel><Researchers><Rodent><Rodentia><Rodents Mammals><Science><Skin><Skin development><Solid><Time><Variant><Variation><WNT Signaling Pathway><WNT signaling><Work><cell type><comparative><computer biology><developmental><functional genomics><gene expression pattern><gene expression signature><membrane structure><pigment><pigmentations><programs><skin organogenesis><spatial and temporal><spatial temporal><spatiotemporal><success><tool><trait><transcriptional profile><transcriptional signature>
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WEI-JEN TANG

UNIVERSITY OF CHICAGO, CHICAGO, IL

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$470,385
FY 2026

Project Title

R35 Investigate structure and function of human amyloid-peptide degrading proteases

Grant Number:

1R35GM162573-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Abstract/Summary: Aggregates of amyloid peptides are highly cytotoxic and associated with human illnesses such as Alzheimer's disease, Parkinson's disease, and systemic amyloidoses (e.g., AL and AA amyloidosis). These toxic amyloid aggregates form through cross-β-sheet formation between amy...

Research Terms

<ACE Inhibitors><AD dementia><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimers Dementia><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Fibrils><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Amyloidosis><Angiotensin I-Converting Enzyme Inhibitors><Angiotensin-Converting Enzyme Antagonists><Angiotensin-Converting Enzyme Inhibitors><Angiotensins><Aβ><Beta Sheet><Biochemical><Biophysics><Cell membrane><Cellular Assay><Clinical><Cytoplasmic Membrane><Disease><Disorder><Embryo><Embryonic><Enzyme Gene><Enzymes><Esteroproteases><Extracellular Space><Family><Gene Deletion><Goals><Human><Intercellular Space><Kininase II Antagonists><Kininase II Inhibitors><Length><Link><Mental Retardation><Metallopeptidases><Metalloproteases><Metalloproteinases><Methods><Mice><Mice Mammals><Mitochondria><Mitochondrial Matrix><Modern Man><Molecular><Molecular Configuration><Molecular Conformation><Molecular Dynamics Simulation><Molecular Stereochemistry><Motion><Murine><Mus><Paralysis Agitans><Parkinson><Parkinson Disease><Pathway interactions><Peptidases><Peptide Hydrolases><Peptides><Plasma Membrane><Primary Parkinsonism><Primary Senile Degenerative Dementia><Process><Protease Gene><Proteases><Proteinases><Proteins><Proteolytic Enzymes><Psychoses><Regulation><Role><Structure><Work><a beta peptide><abeta><amyloid beta><amyloid disease><amyloid peptide><amyloid-b protein><beta amyloid fibril><beta pleated sheet><biophysical analysis><biophysical foundation><biophysical principles><biophysical sciences><biophysical studies><cell assay><clinical relevance><clinically relevant><conformation><conformational><conformational state><conformationally><conformations><cytotoxic><dimer><enzyme mechanism><gene deletion mutation><human disease><hypertension treatment><improved><innovate><innovation><innovative><insight><loss of function mutation><mitochondrial><molecular dynamics><monomer><new approaches><novel approaches><novel strategies><novel strategy><pathway><plasmalemma><prevent><preventing><primary degenerative dementia><protein homeostasis><proteostasis><senile dementia of the Alzheimer type><side effect><small molecule><social role><soluble amyloid precursor protein><success><β-Sheet><β-pleated sheet>
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Gideon Bradburd

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$467,512
FY 2026

Project Title

Incorporating geography into statistical methods for analysis of population genomic DNA

Grant Number:

2R35GM137919-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2020

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary In humans, genetic variation is distributed geographically, reflecting the history of human movements across the continents. Understanding these spatial patterns is crucial for many fields in human population genomics, including the study of human evolutionary history and linking gen...

Research Terms

<Address><Biology><Causality><Clinical genetics><DNA Recombination><Data><Data Set><Disease><Disorder><Environment><Etiology><Failure><GWA study><GWAS><Gene variant><Genetic><Genetic Diversity><Genetic Population Study><Genetic Recombination><Genetic Variation><Genome><Genomic DNA><Genomic Segment><Genomics><Genotype><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Geography><Goals><Graph><Historical Demography><History><Human><Human Genetics><Individual><Investigators><Learning><Link><Medical Genetics><Methods><Modeling><Modern Man><Modernization><Movement><Organism><Pattern><Phenotype><Population><Population Analysis><Population Genetics><Prevalence><Recombination><Recording of previous events><Research><Research Personnel><Researchers><Role><Sampling><Shapes><Sight><Statistical Methods><Structure><Time><Vision><Work><allelic variant><body movement><causation><density><disease causation><disease risk><disorder risk><flexibility><flexible><gDNA><genetic variant><genome segment><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic data><genomic dataset><genomic region><genomic variant><geographic site><histories><human disease><human genomics><improved><insight><living system><novel><population movement><programs><social role><statistic methods><tool><visual function><whole genome association analysis><whole genome association study>
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Kasper Daniel Hansen

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$462,324
FY 2026

Project Title

Data Science Tools to Increase Insight in Genomics Data

Grant Number:

5R35GM149323-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

4/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project summary High-throughput molecular technologies are increasingly being used in biomedical and basic science. New tech- nologies and assays are being developed at a rapid pace, and have the potential to interrogate cellular processes at an unprecedented resolution and throughput. As a result o...

Research Terms

<Assay><Basal Transcription Factor><Basal transcription factor genes><Basic Research><Basic Science><Binding><Bioassay><Biological Assay><Cell Cycle><Cell Division Cycle><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><DNA Methylation><DNA Molecular Biology><Data Science><Development><General Transcription Factor Gene><General Transcription Factors><Investigators><Measurement><Measures><Methods><Molecular><Molecular Biology><Molecular Interaction><Research Personnel><Researchers><Resolution><Statistical Methods><Subcellular Process><Technology><Transcription Factor Proto-Oncogene><Transcription factor genes><complex data><developmental><epigenomics><experiment><experimental research><experimental study><experiments><flexibility><flexible><genomic data><genomic dataset><high throughput technology><histone modification><insight><nanopore based sequencing><nanopore long read seq><nanopore long-read sequencing><nanopore seq><nanopore sequencing><nanopore-based long-read sequencing><new technology><novel technologies><resolutions><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><statistic methods><tool><transcription factor>
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John Anthony Capra

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$451,000
FY 2026

Project Title

The Evolution of Gene Regulation and Human Disease

Grant Number:

5R35GM127087-09

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2018

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The long-term mission of my lab is to accurately model the effects of DNA sequence differences between indi- viduals on phenotypes relevant to disease and human evolution. Genetic variants that modify gene regulation are major contributors to both evolutionary divergence between spec...

Research Terms

<Address><Africa><Alleles><Allelomorphs><Area><Basic Research><Basic Science><Biology><Chromosome Mapping><Clinical><Code><Coding System><Computing Methodologies><DNA><DNA Sequence><DNA mutation><Deoxyribonucleic Acid><Disease><Disorder><Evolution><Funding><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Regulation><Gene Regulation Process><Gene variant><Genes><Genetic Change><Genetic Diversity><Genetic Risk><Genetic Variation><Genetic defect><Genetic mutation><Genome><Grant><History><Human><Individual><Linkage Mapping><Machine Learning><Manuscripts><Methods><Mission><Modeling><Modern Man><Mutation><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Patients><Pattern><Persons><Phenotype><Population><Position><Positioning Attribute><Preventative care><Preventive care><Recording of previous events><Regulatory Element><Regulatory Regions><Risk><Shapes><Source><Technology><Testing><Total Human and Non-Human Gene Mapping><Transgenes><Variant><Variation><Work><allelic variant><computational methodology><computational methods><computer based method><computer methods><computing method><disease risk><disorder risk><flexibility><flexible><functional genomics><genetic mapping><genetic regulatory element><genetic variant><genome mutation><genomic data><genomic dataset><genomic variant><histories><human disease><machine based learning><machine learning based method><machine learning method><machine learning methodologies><molecular phenotype><programs><success><trait><transgene><trend>
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PHILIP A COLE

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$447,500
FY 2026

Project Title

Chemical Approaches to Understanding Reversible Lysine Modifications

Grant Number:

5R35GM149229-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

R35GM149229 Abstract This is an R35 NIGMS application that is meant to succeed R37GM62437 and concerns the development and application of chemical approaches to enhance our understanding of histone post-translational modifications (PTMs) on Lys residues and the enzymes that attach and remove them (“...

Research Terms

<AOF2><Acetylation><Acetyltransferase><Biochemical><Biology><Cancers><Cell Body><Cells><Chemicals><Chromatin><Closure by Ligation><Complex><Deacetylase><Development><Diagnosis><Disease><Disorder><E1A Binding Protein p300><EP300><EP300 gene><Engineering><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Gatekeeping><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Inactivation><Gene Regulation><Gene Regulation Process><Gene Silencing><Generations><Genes><HD1><HDAC1><HDAC1 gene><Histone Deacetylase 1><Histone H3><Histones><Human><Investigators><Isoforms><KAT3B><KDM1A><KDM1A gene><Knowledge><L-Lysine><LSD1><Ligation><Lysine><Lysine-Specific Demethylase 1><Lysine-Specific Demethylase 1A><Malignant Neoplasms><Malignant Tumor><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Methods><Modern Man><Modification><Molecular><NIGMS><National Institute of General Medical Sciences><Nucleosomes><PRC1><PRC1 Protein><Paste substance><Pastes><Pattern><Phase><Polycomb Repressive Complex 1><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Predisposition><Production><Protein Isoforms><Protein Modification><Proteins><Proteomics><RPD3-Like 1><RPD3L1><Reduced Potassium Dependency 3, Yeast, Homolog-Like 1><Research><Research Personnel><Researchers><SAGA><SPT/ADA/Gcn5 Acetyltransferase><Site><Susceptibility><Tail><Therapeutic><Training><Writing><analog><cell type><combat><de-ubiquitinase><de-ubiquitinating enzyme><demethylation><design><designing><developmental><epigenetically><experiment><experimental research><experimental study><experiments><gatekeeper><histone acetyltransferase p300><histone modification><inhibitor><innovate><innovation><innovative><malignancy><neoplasm/cancer><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><p300><pharmacologic><pre-clinical><preclinical><programs><response><sortase><srtA gene product><transcriptional silencing><ubiquitin isopeptidase><ubiquitin-specific isopeptidase>
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Amy Goldberg

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$446,119
FY 2026

Project Title

Evolution on epidemiologically-relevant timescales

Grant Number:

5R35GM133481-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2019

End Date:

4/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Genetic variation encodes the history of our species, underlies our ability to adapt to new environments, and is the basis for individual- and population-specific disease risk. Over billions of years, evolution has transformed living organisms from simple single cells to the huge div...

Research Terms

<Admixture><Adopted><Agriculture><Area><Biologic Models><Biological Models><Case Study><Case-Base Studies><Cell Body><Cells><Chromosomes><Communicable Diseases><Complex><Computing Methodologies><DNA Recombination><DNA Resequencing><DNA mutation><Disease><Disorder><Environment><Epidemiology><Evolution><Explosion><Gene variant><Generations><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Recombination><Genetic Variation><Genetic defect><Genetic mutation><Genome><History><Human><Human Genetics><Individual><Infectious Diseases><Infectious Disorder><Karyotype><Life Cycle><Life Cycle Stages><Malaria><Mammalia><Mammals><Model System><Modeling><Modern Man><Mutation><Organism><Paludism><Pattern><Phenotype><Phylogenetic Analysis><Phylogenetics><Plasmodium Infections><Population><Population Genetics><Population Sizes><Primates><Primates Mammals><Process><Radiation><Recombination><Recording of previous events><Resequencing><Shapes><System><Technology><Testing><Theoretic Models><Theoretical model><Time><Transmission><Variant><Variation><Work><allelic variant><case report><computational methodology><computational methods><computer based method><computer methods><computing method><disease risk><disorder risk><dynamic system><dynamical system><entire genome><epidemiologic><epidemiological><flexibility><flexible><full genome><genetic architecture><genetic variant><genome mutation><genomic variant><histories><human model><karyogram><life course><living system><model of human><pathogen><simulation><statistics><structural mutation><structural variant><structural variation><tool><transmission process><whole genome>
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DANIEL R SCHRIDER

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$422,533
FY 2026

Project Title

Advancing evolutionary genetics through deep learning

Grant Number:

5R35GM138286-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2020

End Date:

4/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Background: A major challenge in evolutionary genomics is to characterize the forces shaping patterns of genetic variation. For instance, disentangling the effects of natural selection on genetic diversity from those of demographic changes is notoriously challenging. This qu...

Research Terms

<AI language models><Address><Chromosomes><Computer Software Tools><Data><Data Analyses><Data Analysis><Data Set><Development><Dimensions><Drosophila><Drosophila genus><Genes><Genetic><Genetic Diversity><Genetic Variation><Genome><Genomics><Health><Insecticides><Investigators><Methodology><Methods><Modernization><Natural Language Processing><Natural Selections><Pattern><Play><Process><Productivity><Research Personnel><Researchers><Resistance><Route><Sequence Alignment><Shapes><Software Tools><Surface><Transformer language model><Trees><Variant><Variation><Work><anthropogenesis><anthropogenic><artificial intelligence language models><data interpretation><deep learning><deep learning method><deep learning strategy><developmental><fruit fly><genomic data><genomic dataset><high dimensionality><insight><large language model><large scale language model><machine learning based method><machine learning method><machine learning methodologies><massive scale language models><natural language understanding><neural network><new approaches><novel approaches><novel strategies><novel strategy><pressure><resistant><sequencing alignment><software toolkit><success><tool><vector mosquito>
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Young Kwon

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$419,850
FY 2026

Project Title

Complex Cell Behaviors During Epithelial Homeostasis and Stress

Grant Number:

5R35GM128752-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2018

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Maintaining epithelial homeostasis is crucial for organismal health since its disruption is linked to multiple human diseases, such as cancers. Cells elicit many behaviors to maintain the structure and function of epithelia during normal homeostasis and stress. Comprehending their be...

Research Terms

<5'-Adenylic acid><Actins><Address><Adenosine Monophosphate><Adenylic Acid><Adherens Junction><Adhering Junction><Adhesive Junction><Adult females><Adult women><Affect><Age><Alleles><Allelomorphs><Anchoring Junction><Animals><Antimorphic mutation><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Behavior><Biochemistry><Biologic Models><Biological><Biological Chemistry><Biological Models><Body Tissues><Brachydanio rerio><CDC42><CDC42 gene><CDC42Hs><Cadherin-1><Calcium><Cancers><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cell fusion><Cells><Cellular Matrix><Chemicals><Collection><Communication><Complex><Cues><Culture Techniques><Cyclic GMP><Cytoplasm><Cytoskeletal Modeling><Cytoskeletal Organization><Cytoskeletal Organization Process><Cytoskeletal Reorganization><Cytoskeletal System><Cytoskeleton><Cytosol><DNA><DNA Binding Domain><DNA Recombination><DNA-Binding Protein Motifs><Danio rerio><Data><Deoxyribonucleic Acid><Development><Disease><Disorder><Dominant Negative><Dominant-Negative Mutant><Dominant-Negative Mutation><Double-Stranded DNA><Double-Stranded RNA><Drosophila><Drosophila genus><E-Cadherin><EGF><EGF gene><Ensure><Epithelial Calcium-Dependent Adhesion Protein><Epithelial Cells><Epithelial-Cadherin><Epithelium><Event><Female><Females in adulthood><Flies><Funding><G25K><Gene Alteration><Gene Mutation><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Generations><Genes><Genetic><Genetic Markers><Genetic Recombination><Genome><Goals><Growth><Guanosine Cyclic Monophosphate><Health><Hemocytes><Homeostasis><Human><IP3R><IP3R1><ITPR1><ITPR1 gene><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Immune><Immune response><Immunes><Impairment><Individual><Infiltration><Innate Immune Response><Inositol 1,4,5-Triphosphate Receptor Type 1><Insp3r1><Intestinal><Intestinal Neoplasia><Intestinal Neoplasms><Intestinal Tumor><Intestines><Intestines Neoplasms><Intracellular Communication and Signaling><Intracellular Second Messenger><Investigation><Knowledge><Label><Learning><Length><Ligands><Link><Macrophage><Maintenance><Malignant Neoplasms><Malignant Tumor><Measures><Mediating><Model System><Modeling><Modern Man><Molecular><Monitor><Myosin A><Myosin II><Myosin IIA><Myosin Type II><Mφ><Natural regeneration><Non-Muscle Myosin Type IIA><Nonmuscle Myosin Type IIA><Nucleus><Oncogenic><Organ><Ortholog><Orthologous Gene><Pathway interactions><Pattern><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Pigments><Play><Population><Post-Transcriptional Gene Silencing><Postdoc><Postdoctoral Fellow><Procedures><Process><Progenitor Cells><Property><Proteins><RNA Interference><RNA Silencing><RNAi><Receptor Protein><Recombination><Regeneration><Reproducibility of Findings><Reproducibility of Results><Research><Research Associate><Role><STIM1><STIM1 gene><Sample Size><Sampling><Second Messenger Systems><Second Messengers><Sequence-Specific Posttranscriptional Gene Silencing><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Site><Staining method><Stains><Statistical Methods><Stimulator of Interferon Genes><Stop Codon><Stress><Stromal Interaction Molecule 1><Structure><Study models><System><Techniques><Termination Codon><Terminator Codon><Testing><Time><Tissue Growth><Tissues><Training><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activation Domain><Transgenes><Transgenic Organisms><Translation Stop Signal><Transplantation><Tumor Cell><Uvomorulin><Vesicle><Width><Women in adulthood><Work><Yeasts><Zebra Danio><Zebra Fish><Zebrafish><ages><biologic><biological signal transduction><blebbistatin><bowel><cGAMP STING><cGAMP-STING><cGAMP/STING><cGAS/STING><cGMP><calcium indicator><cell behavior><cell type><cellular behavior><cyclic GMP-AMP synthase/STING><design><designing><detector><developmental><ds-DNA><dsDNA><dsRNA><experiment><experimental research><experimental study><experiments><fly><fruit fly><gender difference><gender-associated difference><gene biomarker><gene defect><gene expression biomarker><gene manipulation><gene marker><gene signature biomarker><genetic biomarker><genetic manipulation><genetically manipulate><genetically perturb><good laboratory practice><graduate student><host response><human disease><imaging><immune system response><immunoresponse><improved><in vivo><inhibitor><injury to tissue><insight><intestinal epithelium><intracellular skeleton><knock-down><knockdown><male><malignancy><mutant allele><neoplasm/cancer><neoplastic cell><notch><notch protein><notch receptors><ontogeny><paralog><paralogous gene><pathway><pigment><post-doc><post-doctoral><post-doctoral trainee><power analysis><prevent><preventing><promoter><promotor><receptor><recombinase><reconstitute><reconstitution><recruit><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><repair><repaired><research associates><response><sex><signal transduction second messengers><single cell next generation sequencing><single cell sequencing><social role><statistic methods><stem cells><tissue injury><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><tool><transcription factor><transdifferentiation><transgene><transgenic><transplant><undergrad><undergraduate><undergraduate student><♀><♂>
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Christina Kendziorski

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$413,001
FY 2026

Project Title

Computational systems for single-cell and spatial transcriptomics experiments

Grant Number:

1R35GM162239-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract This R35 Maximizing Investigators’ Research Award (MIRA) proposal aims to develop computational systems to address critical challenges in single-cell and spatial transcriptomics experiments. Single-cell and spatial transcriptomics experiments allow us to measure genome-wide gene expression ...

Research Terms

<AI Augmented><AI assisted><AI driven><AI enhanced><AI integrated><AI powered><AI system><Address><Artificial Intelligence><Artificial Intelligence enhanced><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Award><Benchmarking><Best Practice Analysis><Blood><Blood Reticuloendothelial System><Body Tissues><Cell Body><Cells><Clinical><Communities><Complex Analysis><Computer Reasoning><Computer software><Computing Methodologies><Data><Data Analyses><Data Analysis><Data Science><Development><Disease><Disorder><Foundations><Gene Expression><Genomics><Individual><Investigators><Machine Intelligence><Measurement><Measures><Methods><Modeling><Research><Research Personnel><Researchers><Software><Spottings><System><Technology><Tissues><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><benchmark><computational methodology><computational methods><computer based method><computer methods><computing method><data interpretation><developmental><enhanced with AI><enhanced with Artificial Intelligence><experiment><experimental research><experimental study><experiments><genome scale><genome-wide><genomewide><improved><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><tool><tumor>
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Jonas C Peters

CALIFORNIA INSTITUTE OF TECHNOLOGY, PASADENA, CA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$409,720
FY 2026

Project Title

Catalytic Nitrogen Fixation and C-N Bond Constructions Mediated by Iron and Copper as Models of Biocatalysis and Tools for Organic Synthesis

Grant Number:

5R35GM153322-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

4/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary - Catalytic nitrogen fixation and C–N bond constructions mediated by iron and copper as models of biocatalysis and tools for organic synthesis This R35 application requests support to expand research funded via NIGMS in the Peters laboratory during the past five years (JCP as PI: R01...

Research Terms

<9-azafluorene><Address><Alkylation><Amides><Amination><Amines><Ammonia><Aniline><Biologic Models><Biological Models><Bromides><Carbazoles><Carbon><Catalysis><Chemistry><Chlorides><Complex><Copper><Coupling><Cu element><Data><Development><Dinitrogenase><Drugs><Electron Transport><Electrons><Enzyme Gene><Enzymes><Fe element><Funding><Investigators><Iodides><Iron><Laboratories><Life><Ligands><Mediating><Medication><Medicine><Methods><Model System><Modeling><NIGMS><NIH RFA><National Institute of General Medical Sciences><Negative Beta Particle><Negatrons><Nitrogen><Nitrogen Fixation><Nitrogenase><Organic Synthesis><Pathway interactions><Pharmaceutical Preparations><Property><Reagent><Request for Applications><Research><Research Personnel><Researchers><Role><Route><Source><Testing><amine><benzenamine><catalyst><chelation><developmental><dibenzopyrrole><diphenylenimine><drug candidate><drug/agent><electron transfer><fascinate><oxidation><pathway><social role><tool>
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Ming Xian

BROWN UNIVERSITY, PROVIDENCE, RI

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$398,782
FY 2026

Project Title

Explore the Chemistry and Chemical Biology of Reactive Sulfur Species

Grant Number:

5R35GM149170-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Explore the Chemistry and Chemical Biology of Reactive Sulfur Species Reactive sulfur species (RSS) include hydrogen sulfide (H2S), persulfides (RSSH), polysulfides (H2Sn or RSSnR, n≥2), and cysteine-modified adducts like S-nitrosothiols (SNO). These species play regulatory roles in...

Research Terms

<Address><Biological><Biology><Biomedical Research><Chemicals><Chemistry><Clinical><Cysteine><Detection><Diagnostic><Disease><Disorder><Fluorescence Agents><Fluorescent Agents><Fluorescent Dyes><Generations><H element><Half-Cystine><Hydrogen><Hydrogen Sulfide><L-Cysteine><Oxidation-Reduction><Physiologic><Physiological><Play><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Property><Protein Modification><Reaction><Redox><Research><Role><S element><S-Nitrosothiols><Sulfur><System><Therapeutic><Xanthenes><adduct><biologic><clinical applicability><clinical application><fluorescent dye/probe><next generation><novel><oxidation reduction reaction><persulfides><polysulfide><programs><sensor><social role><tool>
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Jimena Giudice

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$383,755
FY 2026

Project Title

When alternative splicing meets cytoskeleton organization, local translation, and transcription regulation

Grant Number:

5R35GM152426-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/9/2024

End Date:

4/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Alternative splicing is an RNA processing mechanism that explains how single genes can produce more than one transcript. Alternative splicing is a rule rather than an ...

Research Terms

<Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Architecture><Area><Basal Transcription Factor><Basal transcription factor genes><Body Tissues><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Matrix><Cellular Physiology><Cellular Process><Chromatin><Curiosities><Cytoplasm><Cytoskeletal Modeling><Cytoskeletal Organization><Cytoskeletal Organization Process><Cytoskeletal Reorganization><Cytoskeletal System><Cytoskeleton><DNA><Defect><Deoxyribonucleic Acid><Development><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Eukaryota><Eukaryote><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Materials><Genetic Transcription><Health><Heart Muscle Cells><Heart myocyte><Human><Individual><Life><Maintenance><Mechanics><Membrane><Modern Man><Muscle Disease><Muscle Disorders><Muscle Fibers><Muscular Diseases><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Myotubes><NIGMS><National Institute of General Medical Sciences><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Non-Polyadenylated RNA><Nucleus><Organ><Pathologic><Phase><Physiology><Proteins><RNA><RNA Expression><RNA Gene Products><RNA Processing><RNA Splicing><Regulation><Research><Rhabdomyocyte><Ribonucleic Acid><Role><Skeletal Fiber><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Splicing><Subcellular Process><Text><Time><Tissues><Transcript><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Translational Regulation><Translations><Tube><Variant><Variation><cardiomyocyte><cellular differentiation><developmental><epigenetically><genome wide analysis><genome wide studies><genome-wide analysis><genome-wide identification><interest><intracellular skeleton><mechanic><mechanical><membrane structure><muscular disorder><neuronal><organ development><organ growth><physiologic model><programs><protein function><social role><synergism><trafficking><transcription factor><translation>
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Sara Molinari

UNIV OF MARYLAND, COLLEGE PARK, COLLEGE PARK, MD

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$382,136
FY 2026

Project Title

Engineering bacterial multicellular structures for therapeutic applications

Grant Number:

5R35GM157144-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The long-term goal of this R35 research plan is to define the engineering principles to rationally design programmable bioengineered multicellular structures (ProBioMS) in prokaryotic cells. Modeled after natural probiotic strains, ProBioMS are promising probiotic-based therapeutics....

Research Terms

<Adherence><Articulation><Bacteria><Binding><Biocompatible Materials><Biomaterials><Biomedical Engineering><Body Tissues><Body cavities><Cell Body><Cell Communication><Cell Components><Cell Interaction><Cell Structure><Cell surface><Cell-to-Cell Interaction><Cells><Cellular Structures><Characteristics><Development><Disease><Disorder><Drugs><Engineering><Foundations><Future><Genetic><Goals><Length><Mediating><Medication><Metabolic Clearance Rate><Methods><Microscopic><Mission><Modeling><Molecular Interaction><NIGMS><National Institute of General Medical Sciences><Paste substance><Pastes><Peptides><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Probiotics><Prokaryotae><Prokaryotic Cells><Regulation><Research><Surface><Technology><Therapeutic><Time><Tissues><Vaginal Cream><bio-engineered><bio-engineers><bioengineering><biological engineering><biological material><body cavity><clearance rate><computational framework><computer framework><density><design><designing><developmental><drug/agent><genetically engineered cells><genetically modified cells><innovate><innovation><innovative><new technology><novel><novel technologies><pharmaceutical><programs><prokaryote><rational design><self assembly><side effect><synthetic biology><tech development><technology development><therapeutically effective><tool><virtual><wound care dressing><wound dressing>
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Hongkuan Fan

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$377,539
FY 2026

Project Title

The Role of Pericytes in the Vascular Dysfunction of Sepsis

Grant Number:

5R35GM149203-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary: Sepsis affects more than 19 million people each year. With improved treatment strategies, more and more patients survive sepsis. The majority of these survivors develop cognitive impairment and mental health problems. However, the mechanisms that promote sepsis-associated encephalo...

Research Terms

<Adventitial Cell><Affect><Ammon Horn><Animal Model><Animal Models and Related Studies><Antisense Agent><Antisense Oligonucleotides><Apoptosis><Apoptosis Pathway><Apoptosis-Related Cysteine Protease Caspase 1><Autopsy><Blood - brain barrier anatomy><Blood Vessels><Blood monocyte><Blood-Brain Barrier><Brain><Brain Nervous System><Brain Vascular Disorders><CASP-1><CASP1><CASP1 gene><Caspase-1><Caspase-1 Gene><Cell Body><Cells><Cerebral vascular pericyte><Cerebrovascular Circulation><Cerebrovascular Disease><Cerebrovascular Disorders><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Cytometry><Development><Disturbance in cognition><ERGB Transcription Factor><EWSR2><Encephalon><Encephalopathies><Ewing Sarcoma Breakpoint Region 2><Exhibits><Extravasation><FLI1><FLI1 Protein><FLI1 Transcription Factor><FLI1 gene><Fli-1 proto-oncogene, ETS transcription factor><Friend Leukemia Virus Integration 1 Protein><Friend Leukemia Virus Integration 1 Transcription Factor><Friend leukemia virus integration 1><Goals><Hemato-Encephalic Barrier><Hippocampus><ICE Protease><IL-1 beta Convertase><IL-1 beta-Converting Enzyme><IL-1BC><IL-1b Converting Enzyme><IL1B-Convertase><IL1BC><IL1BCE><Image><Impaired cognition><Impaired health><Inflammation Mediators><Inflammatory><Interleukin 1-B Converting Enzyme><Interleukin 1-Beta Convertase><Interleukin-1 Beta Converting Enzyme><Interleukin-1 Converting Enzyme><Intracranial Vascular Diseases><Intracranial Vascular Disorders><KO mice><Knock-out Mice><Knockout Mice><Laboratories><Leakage><Marrow monocyte><Memory Deficit><Memory impairment><Mental Health><Mental Hygiene><Mice><Mice Mammals><Murine><Mus><Neuronal Dysfunction><Null Mouse><Pathologic><Patients><Pericapillary Cell><Pericytes><Perivascular Cell><Persons><Play><Production><Programmed Cell Death><Psychological Health><Reporting><Research><Role><Rouget Cells><SIC-1><Sepsis><Single-Nucleus Sequencing><Spillage><Survivors><Vascular Cognitive Impairment><Vascular Diseases><Vascular Disorder><after sepsis><after septic><antisense oligo><antisepsis treatment><blood flow in brain><blood vessel disorder><bloodbrain barrier><brain blood circulation><brain blood flow><brain pericytes><brain perivascular cell><brain tissue><brain vascular disease><brain vascular dysfunction><brain vascular pericyte><cerebral blood flow><cerebral circulation><cerebral pericyte><cerebral vascular disease><cerebral vascular dysfunction><cerebrocirculation><cerebrovascular blood flow><cerebrovascular contribution to cognitive impairment><cerebrovascular contributions to cognitive dysfunction><cerebrovascular dysfunction><cerebrovascular pericyte><cognitive dysfunction><cognitive loss><compare to control><comparison control><developmental><following sepsis><following septic><hippocampal><imaging><improved><individuals with sepsis><inflammatory mediator><intracranial vascular dysfunction><memory dysfunction><model of animal><monocyte><necropsy><neural dysfunction><neural inflammation><neuro-vascular unit><neuroinflammation><neuroinflammatory><neurovascular unit><novel><patients with sepsis><people with sepsis><post sepsis><post septic><postmortem><programs><recruit><response><sNuc-Seq><sepsis care><sepsis groups><sepsis interventions><sepsis management><sepsis patients><sepsis population><sepsis subjects><sepsis survivor><sepsis survivorship><sepsis therapeutics><sepsis therapy><sepsis treatment><septic group><septic individuals><septic patients><septic people><septic population><septic subject><septic survival><septic survivor><septic therapy><septic treatment><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><subjects with sepsis><survive sepsis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><treat sepsis><treatment strategy><vascular><vascular and cognitive impairment><vascular cognition impairment><vascular cognitive decline><vascular cognitive disease><vascular cognitive disorder><vascular cognitive dysfunction><vascular contributions to cognitive decline><vascular contributions to cognitive impairment><vascular disease and impaired cognition><vascular dysfunction><vascular dysfunction resulting in cognitive decline><vascular related cognitive decline><vascular related cognitive impairment><vasculopathy>
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Ann Louise Miller

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$376,558
FY 2026

Project Title

Epithelial cell-cell junction remodeling in response to cell- and tissue-scale forces

Grant Number:

5R35GM153204-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY / ABSTRACT The overarching goal in my lab is to identify mechanisms that promote maintenance, reinforcement, and remodeling of cell-cell adhesion and barrier function in response to cell-scale and tissue-scale forces. Epithelial cell-cell junctions including adherens junctions, tight...

Research Terms

<Actins><Actomyosin><Adherens Junction><Adhering Junction><Adhesions><Adhesive Junction><Anchoring Junction><Apical><Architecture><Assay><Bioassay><Biological Assay><Body Tissues><Calcium><Cancers><Cell Body><Cell Communication and Signaling><Cell Junctions><Cell Signaling><Cell-Cell Adhesion><Cells><Cellular Matrix><Cytokinesis><Cytoplasmic Division><Cytoskeletal System><Cytoskeleton><Disease><Disorder><Embryo><Embryonic><Engineering / Architecture><Ensure><Environment><Epithelial Cells><Epithelium><Flare><Goals><Image><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intercellular Junctions><Intracellular Communication and Signaling><Maintenance><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mechanics><Mediating><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Microscopy><Modeling><Molecular><Morphogenesis><Neoplasm Metastasis><Occluding Junctions><Organism><Pathogenesis><Physiologic><Physiological><Platanna><Proteins><Psychological reinforcement><Reinforcement><Research><Scaffolding Protein><Secondary Neoplasm><Secondary Tumor><Shapes><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Tight Junctions><Tissues><Transmission><Work><Xenopus laevis><Zonula Occludens><biological signal transduction><cancer cell><cancer metastasis><flexibility><flexible><imaging><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><intestinal autoinflammation><intracellular skeleton><living system><malignancy><mechanic><mechanical><mechanical force><morphogenetic process><neoplasm/cancer><novel><recruit><repair><repaired><response><rho><rho G-Proteins><rho GTP-Binding Proteins><rho GTPase-activating protein><rho GTPases><rho Protein P21><rho Small GTP-Binding Proteins><rhoGAP><tool><transmission process><tumor cell metastasis>
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Rees F Garmann

SAN DIEGO STATE UNIVERSITY, SAN DIEGO, CA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$376,250
FY 2026

Project Title

Direct measurements of RNA virus nucleocapsid self-assembly and disassembly

Grant Number:

5R35GM157105-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/10/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. This R35 MIRA proposal aims to measure and understand the molecular mechanisms of viral nucleocapsid self-assembly and disassembly through a combination of quantitativ...

Research Terms

<Address><Anti-viral Agents><Biological><Capsid><Cell Body><Cells><Complex><Cryo-electron Microscopy><Cryoelectron Microscopy><Disease><Disorder><Electron Cryomicroscopy><Genetic Medicine><Genome><Goals><Measurement><Measures><Methods><Microscopy><Molecular><Non-Polyadenylated RNA><Nucleocapsid><Process><Proteins><RNA><RNA Gene Products><RNA Sequences><RNA Viruses><Research><Ribonucleic Acid><Role><Structure><System><Text><Therapeutic><Training><Viral><Viral Packaging><Virus><Virus Packagings><Work><anti-viral compound><anti-viral drugs><anti-viral medication><anti-viral therapeutic><anti-virals><biologic><career development><cryo-EM><cryoEM><cryogenic electron microscopy><design><designing><graduate student><next generation><particle><pathogenic virus><self assembly><social role><undergrad><undergraduate><undergraduate student><viral pathogen><virus pathogen>
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Pankaj Baral

KANSAS STATE UNIVERSITY, MANHATTAN, KS

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$375,394
FY 2026

Project Title

Neuronal regulation of tissue-resident macrophage maintenance and polarization

Grant Number:

5R35GM155117-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

4/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The barrier tissues and body cavities are densely innervated by nociceptor sensory neurons (or nociceptors) that respond to noxious stimuli and mediate pain. Nociceptive innervation in the lung and peritoneal cavity begins as early as the embryonic development stage. Similarly, long-...

Research Terms

<Address><Afferent Neurons><Alveolar Macrophages><Autoregulation><Body Tissues><Body cavities><Calcitonin Gene-Related Peptide><Cell Communication and Signaling><Cell Signaling><Complex><Data><Development><Disease><Disorder><Dysfunction><Embryo Development><Embryogenesis><Embryonic Development><Exhibits><Functional disorder><Greater sac of peritoneum><Homeostasis><Immunomodulation><Infection><Inflammation><Inflammatory><Injury><Innate Immune Response><Intracellular Communication and Signaling><Knowledge><Life><Ligands><Lung><Lung Respiratory System><Macrophage><Maintenance><Mediating><Mice><Mice Mammals><Modality><Modeling><Murine><Mus><Mφ><Nerve><Nerve Cells><Nerve Fibers><Nerve Unit><Nervous System><Neural Cell><Neurocyte><Neurologic Body System><Neurologic Organ System><Neurons><Neuropeptide Receptor><Neuropeptides><Nociception><Nociceptors><Pain><Painful><Pathogenesis><Peripheral><Peritoneal Cavity><Peritoneal Macrophages><Physiological Homeostasis><Physiopathology><Pulmonary Macrophages><Receptor Protein><Receptor Signaling><Regulation><Research><Role><Sensory Neurons><Sepsis><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Site><Stimulus><System><Therapeutic><Tissues><biological signal transduction><body cavity><developmental><gain of function><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><improved><in vivo><injuries><innervation><loss of function><nerve supply><neuronal><nociceptive><nociceptive neurons><pain-sensing neurons><pain-sensing sensory neurons><pain-sensing somatosensory neurons><pathophysiology><programs><receptor><repair><repaired><social role><tissue repair>
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ALBERT R LA SPADA

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 60/100
Likely hiring
Large award
Active award
$1,162,302
FY 2025

Project Title

La Spada Outstanding Investigator Award

Grant Number:

5R35NS122140-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2021

End Date:

4/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Abstract I have been studying neurodegenerative disease for more than 30 years. While a graduate student, I identified the cause of X-linked spinal and bulbar muscular atrophy (SBMA) as the expansion of a CAG repeat in the androgen receptor (AR) gene. As the first disorder shown to be caused by a CA...

Research Terms

<AR gene><Abscission><Active Follow-up><Aging><Agonist><Androgen Receptor><Area><Autoregulation><Award><BAC clone><BACs><Bacterial Artificial Chromosomes><Bulbospinal Neuronopathy><CAG repeat><CAG trinucleotide repeat><Cerebral cortex><Communication><Corpus Striatum><Corpus striatum structure><Degenerative Neurologic Disorders><Development><Development and Research><Dihydrotestosterone Receptor><Disease><Disorder><Dysfunction><Excision><Extirpation><Functional disorder><Funding><Gene Expression><Gene Transcription><Genetic Transcription><Grant><HD Gene><HD protein><Hereditary><Homeostasis><Hortega cell><Huntingtin><Huntingtin Protein><Huntington Chorea><Huntington Disease><Huntington gene><Huntington protein><Huntington's><Huntington's Disease><Huntington's disease gene product><Huntingtons Disease><IT15 gene><Inherited><Investigation><Investigators><Kennedy Syndrome><Kennedy's Disease><Link><Lower Motor Neuron Disease><Metabolic><Mice><Mice Mammals><Microglia><Molecular><Motor Cell><Motor Neuron Disease><Motor Neurons><Murine><Mus><Muscle Atrophy><Muscular Atrophy><Myoneural Junction><NINDS><NR3C4><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Disorders><Neuromuscular Junction><Neuron Degeneration><Neurons><PPAR delta><PPAR-δ><PPARD protein><PPARdelta><PPARδ><Paper><Pathogenesis><Pathway interactions><Patient-specific stem cells><Peroxisome Proliferator-Activated Receptor delta><Peroxisome Proliferator-Activated Receptor δ><Phenotype><Physiological Homeostasis><Physiopathology><Poly Q><Process><Publishing><R & D><R&D><RNA Expression><Regulation><Removal><Repression><Research><Research Personnel><Researchers><Role><SMAX1><Series><Skeletal Muscle><Spinobulbar Atrophy><Spinobulbar Muscular Atrophy><Spinocerebellar Ataxia-7><Striate Body><Striatum><Surgical Removal><Testing><Time><Transcription><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcriptional Activator/Coactivator><Transgenes><Transgenic Mice><Translational Research><Translational Science><Type 7 Spinocerebellar Ataxia><Voluntary Muscle><Work><X-Linked Bulbo-Spinal Atrophy><active followup><androgen receptor gene><career><decline in function><decline in functional status><degenerative diseases of motor and sensory neurons><degenerative disorder of motor neurons><degenerative neurological diseases><develop therapy><developmental><disease phenotype><flexibility><flexible><follow up><follow-up><followed up><followup><functional decline><functional status decline><gitter cell><global gene expression><global transcription profile><graduate student><interesting transcript 15><intervention development><mesoglia><microglial cell><microgliocyte><mitochondrial dysfunction><motoneuron><motor neuron degeneration><mouse model><murine model><muscle breakdown><muscle degradation><muscle deterioration><muscle loss><muscle wasting><mutant><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroinflammation><neuroinflammatory><neurological degeneration><neurological disease><neuromuscular><neuron toxicity><neuronal><neuronal degeneration><neuronal toxicity><neuroprotection><neuroprotective><neurotoxicity><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathophysiology><pathway><patient progenitor cell><patient stem cell><perivascular glial cell><polyQ><polyglutamine><prevent><preventing><progenitor cell model><progenitor model><programs><research and development><resection><response><skeletal muscle atrophy><skeletal muscle breakdown><skeletal muscle loss><skeletal muscle protein loss><skeletal muscle wasting><social role><spinal and bulbar muscular atrophy><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><striatal><therapy development><transcriptome><transgene><translation research><translational investigation><treatment development>
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STUART A LIPTON

SCRIPPS RESEARCH INSTITUTE, THE, LA JOLLA, CA

Good lead · 60/100
Likely hiring
Large award
Active award
$1,079,483
FY 2025

Project Title

Leadership in AD/ADRD Drug Discovery

Grant Number:

5R35AG071734-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

SUMMARY This R35 leadership application is relevant to Milestone 6D of the goals/milestones of the NIH Alzheimer’s disease and Alzheimer’s disease related dementias (AD/ADRD) Summits—“Initiate drug discovery efforts to develop novel therapeutic agents.” Our overriding goal in this application is to ...

Research Terms

<AD dementia><AD related dementia><ADRD><Address><Affect><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><American><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Award><Aβ><Biochemistry><Bioinformatics><Biological Chemistry><Biology><California><Chemicals><Chemistry><Clinical Trials><Computational Biology><Degenerative Neurologic Disorders><Development><Disease><Disorder><Drug Design><Drug Industry><Drugs><FDA approved><Faculty><Goals><High Throughput Assay><Human><Infrastructure><Institution><Investigation><Investigational Drugs><Investigational New Drugs><Investigators><Knowledge><Laboratories><Leadership><Medical><Medication><Medicinal Chemistry><Medicine><Mentors><Modeling><Modern Man><NIH><National Institutes of Health><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurosciences><Pathway interactions><Pharmaceutic Chemistry><Pharmaceutic Industry><Pharmaceutical Chemistry><Pharmaceutical Industry><Pharmaceutical Preparations><Pharmacology><Prevalence><Primary Senile Degenerative Dementia><Process><Research><Research Personnel><Research Resources><Researchers><Resources><Scientist><Therapeutic><Therapeutic Agents><Training><United States National Institutes of Health><a beta peptide><abeta><aging associated disease><aging associated disorders><aging related disease><aging related disorders><amyloid beta><amyloid-b protein><assay development><beta amyloid fibril><clinical candidate><computer biology><conference><convention><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><drug action><drug development><drug discovery><drug/agent><graduate school><high throughput screening><improved><neurodegenerative illness><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><news><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><primary degenerative dementia><programs><senile dementia of the Alzheimer type><soluble amyloid precursor protein><structural biology><summit><symposia><symposium><therapeutic target><virtual>
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John D Crispino

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

Good lead · 60/100
Likely hiring
Large award
Active award
$1,077,000
FY 2025

Project Title

Identifying the mechanisms of leukemia progression

Grant Number:

5R35CA253096-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/22/2021

End Date:

8/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY Since 2002 when my laboratory discovered GATA1 mutations in all cases acute megakaryocytic leukemia in children with Down syndrome, I have been at the forefront of defining the specific genetic events that promote leukemia. I have extensively studied the role of GATA1 in normal and m...

Research Terms

<21+ years old><AML - Acute Myeloid Leukemia><Acute Megakaryoblastic Leukemia><Acute Megakaryocytic Leukemias><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Anti-Oncogenes><Antioncogenes><Biology><Blood Diseases><Blood megakaryocyte><Bone Marrow Fibrosis><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas9 screen><Cancer Suppressor Genes><Cancers><Chemoprevention><Childhood><Childhood Leukemia><Chromosome 21><DNA mutation><Development><Disease><Disorder><Disparate><Down Syndrome><ERYF1><Emerogenes><Event><GATA Binding Protein 1><GATA-1><GATA1><GATA1 gene><GATA1 protein><GATA1 transcription factor><GF-1 protein><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Laboratories><Langdon Down syndrome><Malignant><Malignant - descriptor><Malignant Neoplasms><Malignant Tumor><Megakaryocytes><Megakaryocytic Leukemia><Megalokaryocyte><Mongolism><Mutation><Myelofibrosis><Myeloid Disease><Myeloid Leukemia, Acute, M7><Myeloid Malignancy><Myeloid Neoplasm><Myeloid Tumor><Myeloproliferative Disorders><Myeloproliferative Tumors><Myeloproliferative disease><Myelosclerosis><NF-E1 erythroid-specific transcription factor><NFE1 protein><Onco-Suppressor Genes><Oncogenes-Tumor Suppressors><Pathogenesis><Pathway interactions><Patients><Pediatric Leukemia><Preleukemia><Preventative strategy><Prevention strategy><Preventive strategy><Recessive Oncogenes><Role><Sampling><Transcription Factor GATA1><Trisomy 21><Tumor Suppressing Genes><Tumor Suppressor Genes><Work><acute granulocytic leukemia><acute myeloid leukemia><adulthood><blood cell formation><blood disorder><children with leukemia><chromosome 21 trisomy><chromosome 21 trisomy syndrome><clustered regularly interspaced short palindromic repeats screen><congenital acromicria syndrome><developmental><genome mutation><globin transcription factor 1><hemopoietic><insight><leukemia><leukemia in children><malignancy><model of animal><morbus Down><myeloproliferative neoplasm><neoplasm/cancer><new approaches><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel approaches><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><nuclear factor-erythroid 1><oncosuppressor gene><pathway><pediatric><prevent><preventing><pseudohypertrophic progressive muscular dystrophy><social role><transcription factor NFE-1><trisomy 21 syndrome><tumor>
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JOHN M MARIS

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Good lead · 60/100
Likely hiring
Large award
Active award
$1,068,000
FY 2025

Project Title

Discovering mechanisms of neuroblastoma tumorigenesis to improve patient outcomes

Grant Number:

2R35CA220500-08A1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2017

End Date:

8/31/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY After stunning improvements in patient outcomes for most childhood cancers in the latter half of the last century, cure rates have since plateaued, and treatment related morbidity continues to mount. Children with metastatic solid malignancies continue to have a less than 50% chance ...

Research Terms

<0-11 years old><Address><Adolescent and Young Adult><Affect><Antibodies><Antibody-drug conjugates><Biological Markers><Biology><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><Cancer Burden><Cancer Cause><Cancer Etiology><Cancer Model><CancerModel><Cancers><Child><Child Youth><Childhood Cancers><Children (0-21)><Clinical Trials><Coupled><Cytotoxic Chemotherapy><Cytotoxic Therapy><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Evolution><Genomics><Goals><Health><Human><Immune Evasion><Immune mediated therapy><Immunologically Directed Therapy><Immunotherapeutic agent><Immunotherapy><Knowledge><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Neoplasms><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant Tumor><Malignant childhood cancer><Methods><Mission><Modern Man><Morbidity><Morbidity - disease rate><Motivation><NIH><National Cancer Burden><National Institutes of Health><Neuroblastoma><Oncogenesis><Oncogenic><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Precision therapeutics><Probability><Public Health><Research><Solid><Stimulus><Sympathetic Nervous System><T cells for CAR><T-Cells><T-Lymphocyte><Therapeutic><Translating><United States National Institutes of Health><Vaccination><attributable death><attributable mortality><bi-specific T cell engager><bio-markers><biologic marker><biomarker><bispecific T cell engager><cancer in a child><cancer in children><child with cancer><childhood malignancy><chimeric antigen T cell receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><customized therapy><customized treatment><design><designing><epigenetically><evidence base><high risk><immune drugs><immune evasive><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapeutics><immune-based therapies><immune-based treatments><immuno therapy><immunologic therapeutics><immunotherapeutics><immunotherapy agent><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><innovate><innovation><innovative><kids><malignancy><metabolic fitness><multidisciplinary><neoplasm/cancer><neuron development><neuronal development><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><patient oriented outcomes><patient specific therapies><patient specific treatment><pediatric cancer><pediatric malignancy><precision therapies><precision treatment><programs><response to therapy><response to treatment><tailored medical treatment><tailored therapy><tailored treatment><therapeutic response><therapy response><thymus derived lymphocyte><treatment response><treatment responsiveness><tumor><tumorigenesis><unique treatment><youngster>
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JAY K KOLLS

TULANE UNIVERSITY OF LOUISIANA, NEW ORLEANS, LA

Good lead · 60/100
Likely hiring
Large award
Active award
$1,063,324
FY 2025

Project Title

CD4+ T cell Immunity in the Respiratory Tract

Grant Number:

1R35HL177381-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/5/2025

End Date:

5/31/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Abstract Pneumonia remains the #1 killer of children in the world and is a leading cause of morbidity and mortality in children in the US and the #8 cause of mortality in adults. Our laboratory has made seminal insights in mechanisms underlying host defense against extracelluar pathogens – particula...

Research Terms

<0-11 years old><21+ years old><Adult><Adult Human><Antigens><Area><Body Tissues><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Child><Child Youth><Children (0-21)><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Feedback><Fibroblasts><Host Defense><Host resistance><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL-22><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immunity><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Intracellular Communication and Signaling><Laboratories><Lung><Lung Respiratory System><Metabolic><Mice><Mice Mammals><Morbidity><Morbidity - disease rate><Murine><Mus><Nasal><Nasal Passages Nose><Nose><Pneumonia><Population><Primates><Primates Mammals><Pulmonary Body System><Pulmonary Organ System><Research><Respiratory System><Respiratory System, Nose, Nasal Passages><Respiratory Tracts><Respiratory tract structure><Sampling><Seminal><Signal Transduction><Signal Transduction Systems><Signaling><Submucosa><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Tissues><adulthood><biological signal transduction><cytokine><epigenetically><immunogen><insight><interleukin-22><kids><memory CD4 T cell><memory CD4 T lymphocyte><mortality><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><new vaccines><next generation therapeutics><next generation vaccines><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><novel vaccines><pathogen><pneumonia therapy><pneumonia treatment><prevent><preventing><pulmonary><thymus derived lymphocyte><treat pneumonia><youngster>
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Mortimer Poncz

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Good lead · 60/100
Likely hiring
Large award
Active award
$1,056,000
FY 2025

Project Title

New Mechanistic Insights & Therapeutic Applications of Megakaryocytes/Platelets

Grant Number:

5R35HL150698-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

4/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT This is an application by Mortimer Poncz, MD, for an NHLBI-supported R35 Outstanding Investigator Award (OIA). Dr. Poncz has made pioneering contributions to the field of platelet (Plt) biology. He isolated and charac- terized the first cDNAs and genes for the Plt proteins (integrin chains...

Research Terms

<AML1><AMLCR1><Affect><Antibodies><Antihemophilic Factor><Antiheparin Factor><Area><Award><Basal Transcription Factor><Basal transcription factor genes><Beds><Benign><Beta-TG><Biology><Bleeding><Blood Clotting><Blood Coagulation Factor VIII><Blood Neutrophil><Blood Platelet Disorders><Blood Platelet Factor IV><Blood Platelet Transfusion><Blood Platelets><Blood Polymorphonuclear Neutrophil><Blood coagulation><Blood megakaryocyte><Blood platelet factor 4><Bone Marrow><Bone Marrow Reticuloendothelial System><CBFA2><CTAP III><CTAP3><CTAPIII><CXC Chemokine Ligand 7><CXCL7><Career Mobility><Caring><Cell Body><Cells><Chemokine (C-X-C motif) Ligand 4><Chemotactic Cytokines><Coagulation Factor VIII><Coagulation Factor VIIIc><Complementary DNA><Connective Tissue-Activating Peptide III><Cytoplasmic Granules><Defect><Disease><Disorder><Factor 4><Factor VIII><Factor VIII Deficiency><Factor VIII F8B><General Transcription Factor Gene><General Transcription Factors><Genes><Glanzmann Thrombasthenia><Grant><Hb SS disease><HbSS disease><Hematology><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hemophilia><Hemophilia A><Hemorrhage><Heparin Neutralizing Protein><Hereditary><Homologous Chemotactic Cytokines><In Situ><In Vitro><Inherited><Integrins><Integrins Extracellular Matrix><Intercrines><Intervention><Investigators><LA-PF4><Lung><Lung Respiratory System><Marrow Neutrophil><Marrow platelet><Medical><Megakaryocytes><Megakaryocytopoieses><Megakaryopoiesis><Megalokaryocyte><Modeling><Molecular><NAP-2><NAP2><NHLBI><National Heart, Lung, and Blood Institute><Nature><Neutrophil-Activating Peptide 2><Neutrophilic Granulocyte><Neutrophilic Leukocyte><PBP gene><PBP protein><PEBP2A2><PEBP2aB><PF4 Gene><PPBP><PPBP gene><Paris><Paris, France><Patients><Physiologic><Physiological><Platelet Basic Protein><Platelet Factor 4><Platelet Transfusion><Platelets><Plts><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Pro-Platelet Basic Protein><Process><Procoagulant Component><Proteins><RUNX1><RUNX1 gene><Recombinant Platelet Factor 4><Research Personnel><Researchers><Risk><Role><SCYB4><SCYB7><SIS cytokines><Sepsis><Sickle Cell Anemia><Site><Small Inducible Cytokine B4><Small Inducible Cytokine Subfamily B, Member 4><Small Inducible Cytokine Subfamily B, Member 7><Syndrome><TC1><TC2><TGB1><Testing><Therapeutic><Thrombasthenia><Thrombocidin 1><Thrombocidin 2><Thrombocytes><Thrombocytopathy><Thrombocytopenia><Thrombocytopoiesis><Thromboglobulin, Beta-1><Thrombopenia><Thromboplastinogen><Thrombopoiesis><Time><Transcription Factor Proto-Oncogene><Transcription factor genes><U-PA><U-Plasminogen Activator><Urinary Plasminogen Activator><Urokinase><Urokinase Plasminogen Activator><Urokinase-Type Plasminogen Activator><Variant><Variation><antihemophilic factor A><antisepsis treatment><beta-Thromboglobulin><blood loss><cDNA><capillary bed><career advancement><career transition><chemoattractant cytokine><chemokine><clinical applicability><clinical application><complex Blood-coagulation factor VIII><extracellular><gamma-Thromboglobulin><granule><heparin-induced thrombocytopenia><iPS><iPSC><iPSCs><improved outcome><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><injury to the vasculature><insight><interest><leukemic transformation><mouse model><murine model><neutrophil><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><platelet cofactor I><platelet disease><platelet disorder><platelet factor IV><polyanion><pulmonary><sepsis care><sepsis interventions><sepsis management><sepsis therapeutics><sepsis therapy><sepsis treatment><septic therapy><septic treatment><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><thromboinflammation><thromboinflammatory><thromboplastinogen A><transcription factor><treat sepsis><vascular injury><β-TG><β-Thromboglobulin>
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Loren David Walensky

DANA-FARBER CANCER INST, BOSTON, MA

Good lead · 60/100
Likely hiring
Large award
Active award
$1,052,251
FY 2025

Project Title

Dissecting and Targeting Deregulated Mitochondrial Apoptosis in Human Cancer

Grant Number:

5R35CA197583-12

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/24/2015

End Date:

7/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT BCL-2 proteins participate in a dynamic interaction network that determines whether a cell will live or die. Deregulation of this essential signaling pathway underlies the pathogenesis of human cancer and resistance to treatment. The goal of this R35 research program is to e...

Research Terms

<Advanced Development><Apoptosis><Apoptosis Pathway><Apoptotic><B cell lymphoma 2><B-Cell CLL/Lymphoma 2 Gene><B-Cell CLL/lymphoma 2><B-Cell Chronic Lymphocytic Leukemia Associated Oncogene><B-cell Leukemia 1><B-cell lymphoma protein 2><B-cell lymphoma/leukemia-2><BAX><BAX gene><BCL><BCL-2 Protein><BCL1 Oncogene><BCL2><BCL2 gene><BCL2 protein><BCL2-Associated X Protein Gene><BCL2L4><Bcl-2><Binding><Binding Sites><Biochemistry><Biological Chemistry><Cancer Biology><Cancer Treatment><Cancers><Cell Body><Cells><Cellular biology><Cessation of life><Chemicals><Chemistry><Chemoresistance><Combining Site><Cysteine><Death><Development><Enzyme Gene><Enzymes><Family><Fatty Acid Metabolism Pathway><Goals><Half-Cystine><Human><In vivo analysis><L-Cysteine><Length><Ligands><Long-Chain-Acyl-CoA Dehydrogenase><Long-Chain-Acyl-Coenzyme A Dehydrogenase><MCL-1><MCL1><MCL1 gene><Maintenance><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mediating><Metabolic><Mitochondria><Modern Man><Modification><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Pathogenesis><Pathologic><Pathway interactions><Pediatric Oncologist><Permeability><Phase><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Programmed Cell Death><Protein Family><Protein Modification><Proteins><Proteomics><Reactive Site><Regulation><Relapse><Research><Resistance><Role><Signal Pathway><Structure><Surface><Technology><VLCAD><Very-Long-Chain Acyl-CoA Dehydrogenase><Work><anti-cancer therapy><bcl-2 Genes><cancer cell metabolism><cancer metabolism><cancer therapy><cancer-directed therapy><ced9 homolog><cell biology><chemoresistant><chemotherapy resistance><chemotherapy resistant><conformation><conformational><conformational state><conformationally><conformations><developmental><fatty acid metabolism><fatty acid oxidation><in vivo evaluation><in vivo testing><inhibitor><insight><interdisciplinary approach><malignancy><mitochondrial><monomer><multidisciplinary approach><mutant><myeloid cell leukemia 1><myeloid cell leukemia sequence 1><myeloid leukemia cell differentiation protein><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><pharmacologic><programs><prototype><refractory cancer><resistant><resistant cancer><social role><structural biology><structural determinants><structural factors><tool><tumor cell metabolism><tumor metabolism>
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Man-Kyo Chung

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 60/100
Likely hiring
Large award
Active award
$1,004,250
FY 2025

Project Title

Trigeminal nociceptors: Neural intersection of chronic pain and alveolar bone remodeling

Grant Number:

5R35DE030045-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/8/2020

End Date:

6/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Orofacial tissues are richly innervated by nociceptive primary afferents (or nociceptors). Nociceptors transmit pain signals into brain in response to harmful stimuli. Nociceptors also intricately regulate homeostasis of innervated tissues by controlling host responses. Under injury or infection, dy...

Research Terms

<Acceleration><Address><Affect><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Area><Autoregulation><Body Tissues><Bone remodeling><Brain><Brain Nervous System><Brain region><CNS plasticity><Chronic Periodontitis><Craniofacial Pain><Dentists><Development><Encephalon><Goals><Homeostasis><Immune response><Infection><Injury><Lead><Methods><Neurobiology><Neuroimmune><Neuronal Plasticity><Neurosciences Research><Nociception><Nociceptors><Oral health><Orthodontic><Outcome><Painless><Pathologic><Pb element><Periodontal Infection><Periodontitis><Physiological Homeostasis><Research><Role><Scientist><Stimulus><Testing><Tissues><Tooth><Tooth Movement><Tooth structure><Transmission><Trigeminal System><Visit><alveolar bone><alveolar supporting bone><bone loss><career><central nervous system plasticity><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><craniofacial><craniofacies><dental health><developmental><head and face pain><heavy metal Pb><heavy metal lead><host response><immune system response><immunoresponse><injuries><interest><maxilla alveolar process><neural><neural plasticity><neurobiological><neuroplastic><neuroplasticity><nociceptive><nociceptive neurons><non-painful><nonpainful><not painful><novel><orofacial><pain killer><pain medication><pain reliever><pain signal><pain-sensing neurons><pain-sensing sensory neurons><pain-sensing somatosensory neurons><painkiller><programs><response><social role><socket wall><teeth><transmission process><treat chronic pain><trigeminal>
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Zeev A. Ronai

CEDARS-SINAI MEDICAL CENTER, LOS ANGELES, CA

Good lead · 60/100
Likely hiring
Large award
Active award
$1,002,000
FY 2025

Project Title

Rewired Signaling at the Nexus of Melanoma Metastasis and Resistance

Grant Number:

5R35CA283706-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Summary This R35 focuses on novel mechanisms underlying control of key UPR components that impact melanoma metastasis in aged rather than young mice by (i) tumor-intrinsic mechanisms (NRF2, ATF4) implicated in resistance or sensitivity to therapy, and (ii) tumor-extrinsic mechanisms that define inte...

Research Terms

<Address><Affect><Aging><Apoptotic><Asparagine Synthase><Asparagine Synthetase><Aspartate-Ammonia Ligase><Biology><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Biology><Cas nuclease technology><Cell Communication and Signaling><Cell Death><Cell Signaling><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><GI microbiota><Gastrointestinal microbiota><Glutaryl-CoA dehydrogenase><Human><Intracellular Communication and Signaling><KO mice><Knock-out Mice><Knockout Mice><Malignant Melanoma><Melanoma><Melanoma Cell><Melanoma Metastasis><Metabolic><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Melanoma><Metastatic Neoplasm><Metastatic Tumor><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Neoplasm Metastasis><Null Mouse><Pathway interactions><Phenotype><Physiologic><Physiological><Process><Regulation><Resistance><Secondary Neoplasm><Secondary Tumor><Signal Transduction><Signal Transduction Systems><Signaling><Tumor Immunity><age associated effects><age effect><age related effects><aged><aged animal><aged animals><aging effect><animal old age><anti-tumor immunity><antitumor immunity><biological signal transduction><cancer immunity><cancer metastasis><conditional knock-out><conditional knockout><elderly animal><enteric microbial community><enteric microbiota><gastrointestinal microbial flora><glutaryl-coenzyme A dehydrogenase><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><impact of age><influence of age><innovative technologies><intestinal flora><intestinal microbiota><intestinal microflora><intestinal tract microflora><juvenile animal><metabolism measurement><metabolomics><metabonomics><microbiota composition><necrocytosis><new approaches><novel><novel approaches><novel strategies><novel strategy><old animals><pathway><resistance to therapy><resistant><resistant to therapy><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><therapeutic resistance><therapy resistant><treatment resistance><tumor><tumor cell metastasis><young animal>
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Hideho Okada

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$943,253
FY 2026

Project Title

Preclinical development of breakthrough immunotherapy for brain tumors

Grant Number:

1R35NS142982-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2026

End Date:

11/30/2033

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract The ultimate success of immunotherapy for brain malignancies, such as malignant glioma, will require integration of in-depth understanding of immunology with solutions for the following long-standing challenges: 1) paucity and heterogeneous expression of glioma-specific antigens; 2) on-targ...

Research Terms

<Adopted><Allogenic><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Antigen Targeting><Antigens><Area><Autologous><Award><Brain><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><CAR T cell therapy><CAR T cells><CAR T therapy><CAR modified T cells><CAR-T><CAR-Ts><Cancers><Cell Body><Cell Therapy><Cells><Collaborations><Data><Encephalon><Engineering><Epitope spreading><Event><Funding><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioblastoma><Glioma><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Heterogeneity><Immune><Immune mediated therapy><Immunes><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologically Directed Therapy><Immunologics><Immunology><Immunomodulation><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunotherapy><Intratumoral heterogeneity><Investigators><Laboratories><Low-Intensity Ultrasound><Low-energy ultrasound><Low-power ultrasound><MHC Receptor><Major Histocompatibility Complex Receptor><Malignant Glial Neoplasm><Malignant Glial Tumor><Malignant Glioma><Malignant Neoplasms><Malignant Neuroglial Neoplasm><Malignant Neuroglial Tumor><Malignant Tumor><Microbubbles><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroglial Neoplasm><Neuroglial Tumor><Neurons><Patients><Phase I Study><Research><Research Personnel><Research Resources><Researchers><Resources><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell receptor based immunotherapy><T cell receptor cellular immunotherapy><T cell receptor engineered therapy><T cell receptor immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cells for CAR><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cell Antigen Receptors><T-Cell Epitopes><T-Cell Receptor><T-Cell Receptor Therapy><T-Cell Receptor Treatment><T-Cell Receptor based Therapy><T-Cell Receptor based Treatment><T-Cells><T-Lymphocyte><T-Lymphocyte Epitopes><T-cell therapeutics><T-cell transfer therapy><TCR T cell immunotherapy><TCR T cell therapy><TCR Therapy><TCR based T cell immunotherapy><TCR based Therapy><TCR based immune therapy><TCR based immunotherapy><TCR based treatment><TCR immunotherapy><Toxic effect><Toxicities><Tumor Antigens><Tumor-Associated Antigen><adaptive immune response><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><anti-cancer immunotherapy><anticancer immunotherapy><antigen spreading><cancer antigens><cancer immunology><cancer immunotherapy><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chimeric antigen T cell receptor><chimeric antigen receptor><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cell therapy><chimeric antigen receptor T cells><chimeric antigen receptor T therapy><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><exhaustion><first in man><first-in-human><flexibility><flexible><glial-derived tumor><glioblastoma multiforme><heterogeneity in tumors><high risk><iPS><iPSC><iPSCs><immune modulation><immune regulation><immune suppression><immune suppressive activity><immune suppressive function><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunosuppressive activity><immunosuppressive function><immunosuppressive response><immunotherapy clinical trials><immunotherapy for cancer><immunotherapy of cancer><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intra-tumoral heterogeneity><intratumor heterogeneity><low intensity pulsed ultrasound><malignancy><multidisciplinary><neo-antigen><neo-epitopes><neoantigens><neoepitopes><neoplasm immunology><neoplasm/cancer><neuroglia neoplasm><neuroglia tumor><neuronal><neuronal circuit><neuronal circuitry><new technology><notch><notch protein><notch receptors><novel><novel technologies><phase 1 study><pre-clinical development><preclinical development><programs><resistance mechanism><resistant mechanism><spongioblastoma multiforme><success><therapeutic T-cell platform><thymus derived lymphocyte><tumor><tumor heterogeneity><tumor immunology><tumor-specific antigen><tumors in the brain>
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Karina Yazdanbakhsh

NEW YORK BLOOD CENTER, NEW YORK, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$902,011
FY 2026

Project Title

Immune Pathophysiology of Sickle Cell Disease

Grant Number:

5R35HL161239-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Abstract A chronic inflammatory state is now considered a hallmark of sickle cell disease (SCD) resulting from ongoing hemolytic insult to the underlying vasculature and repeated cycles of vaso-occlusion crisis (VOC). Transfusions remain a cornerstone treatment for patients with SCD, but unl...

Research Terms

<Affect><Alloantibodies><Alloimmunization><Area><Biologic Models><Biological Models><Blood leukocyte><Blood monocyte><Cell Body><Cells><Chronic><Clinical><Development><Disease><Disorder><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Dysfunction><Endothelium><Enzyme Gene><Enzymes><Event><Experimental Models><Ferroprotoporphyrin><Functional disorder><Goals><HO-1 enzyme><HO1><HO2><HSP32><Hb SS disease><HbSS disease><Heme><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hemolysis><Immune><Immune response><Immunes><In Vitro><Inflammatory><Innate Immune Response><Isoantibodies><Knowledge><Laboratories><Leukocytes><Leukocytes Reticuloendothelial System><Life><Marrow leukocyte><Marrow monocyte><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Mission><Model System><Molecular><NHLBI><National Heart, Lung, and Blood Institute><Pain><Painful><Pathway interactions><Patients><Physiopathology><Protoheme><Reaction><Research><Role><Sampling><Sickle Cell><Sickle Cell Anemia><Transfusion><White Blood Cells><White Cell><blood product><cell type><detoxification><developmental><erythrolysis><ferroheme><heme oxygenase-1><hemeoxygenase 1><host response><human model><immune system response><immunoresponse><in vivo><interest><model of human><monocyte><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathophysiology><pathway><patient population><prevent><preventing><programs><protection pathway><protective pathway><sickle RBC><sickle cell disease><sickle cell disorder><sickle disease><sickle erythrocyte><sickle red blood cell><sicklemia><social role><therapeutic target><white blood cell><white blood corpuscle>
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Edwin R Chapman

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$660,632
FY 2026

Project Title

Fusion pore structure and dynamics

Grant Number:

5R35NS136306-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Membrane fusion is a fundamental process in eukaryotic cells, yet the precise molecular mechanism(s) by which proteins catalyze the merger of lipid bilayers has yet to be elucidated. We address the nanomechanics of membrane fusion reactions by focusing on the fusion of synap...

Research Terms

<Address><Assay><Bioassay><Biological Assay><Biophysics><Cations><Cell Body><Cell Function><Cell Membrane Lipids><Cell Physiology><Cell Process><Cell membrane><Cells><Cellular Function><Cellular Physiology><Cellular Process><Coloring Agents><Communication><Communication Disorders><Communication impairment><Communicative Disorders><Complex><Cryo-electron Microscopy><Cryoelectron Microscopy><Cytoplasmic Membrane><DNA><Deoxyribonucleic Acid><Dyes><Electron Cryomicroscopy><Electrophysiology><Electrophysiology (science)><Eukaryotic Cell><Event><Exocytosis><Extracellular Space><Fertilization><Glutamates><Goals><Intercellular Space><Intervention><Kinetics><L-Glutamate><Lipid Bilayers><Measurement><Measures><Mediating><Membrane><Membrane Fusion><Membrane Lipids><Mental disorders><Mental health disorders><Molecular><NSF attachment protein receptor><Nanostructures><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neural Transmission><Neurocyte><Neurologic Body System><Neurologic Organ System><Neurons><Neurophysiology / Electrophysiology><Optics><Plasma Membrane><Process><Proteins><Psychiatric Disease><Psychiatric Disorder><Radial><Radius><Reaction><Recombinants><Regulation><Running><SNAP receptor><SNARE><Sampling><Secretory Granules><Secretory Vesicles><Structure><Subcellular Process><Synapses><Synaptic><Synaptic Transmission><Synaptic Vesicles><System><Viral><Work><aqueous><biophysical foundation><biophysical principles><biophysical sciences><cryo-EM><cryoEM><cryogenic electron microscopy><electrophysiological><fertilizations><glutamatergic><innovate><innovation><innovative><insight><lipid bilayer membrane><membrane structure><mental illness><nano mechanics><nano-sized structures><nano-structures><nanodisk><nanomechanics><neuronal><neurotransmitter release><novel><optical><particle><plasmalemma><postsynaptic><presynaptic><psychiatric illness><psychological disorder><reconstitute><reconstitution><response><scaffold><scaffolding><soluble N-ethylmaleimide-sensitive-factor attachment protein receptor><synapse><t-SNARE><target SNARE proteins><target membrane SNARE proteins><v-SNAREs><vesicle release><vesicular SNARE proteins><vesicular release><vesicule SNARE proteins>
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Xue Gao

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$455,245
FY 2026

Project Title

Advancing Precision Genome Engineering to Unlock Novel Fungal Natural Products

Grant Number:

2R35GM138207-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2020

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Natural products (NPs) derived from filamentous fungi are essential sources of therapeutic agents, contributing pharmacophores to over 60% of FDA-approved small-molecule drugs. Despite this success, the vast biosynthetic potential of fungi remains untapped, as many biosynthetic gene ...

Research Terms

<Acceleration><Address><Advanced Development><Anabolism><Anti-cancer natural products><Anti-tumor Natural Products><Automobile Driving><Bioinformatics><Biotech><Biotechnology><Chemicals><Complex><Detection><Development><Drugs><Engineering><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Evaluation><FDA approved><Filamentous Fungi><Finding natural products><Funding><Fungal Genome><Fungal natural products><Fungi natural product><Gene Cluster><Gene Transcription><Genetic><Genetic Transcription><Genome engineering><Health><Human><In Situ><Laboratories><Medication><Medicine><Metabolic><Modern Man><Modification><Molds><Natural Products><Natural anti-cancer agents><Natural antineoplastic agents><Natural chemotherapeutic agents><Natural chemotherapeutic products><Natural product anti-neoplastics><Natural product discovery><Output><Oxidases><Pathway interactions><Peptides><Pharmaceutical Preparations><RNA Expression><Regulator Genes><Research><Ribosomes><Screening for cancer><Source><System><Technology><Therapeutic><Therapeutic Agents><Transcription><Transcriptional Regulatory Elements><anti-cancer><anti-microbial><anticancer activity><antimicrobial><base editing><biosynthesis><developmental><driving><drug/agent><early cancer detection><epigenetically><fungus><gene manipulation><gene regulatory network><genetic manipulation><genetic trans acting element><genetically manipulate><genetically perturb><improved><innovate><innovation><innovative><naturally occurring product><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><pharmacophore><prime editing><programs><regulatory gene><screening><screening cancer patients><screenings><small molecule><success><technological innovation><therapeutic candidate><tool><trans acting element>
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Ron Do

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$453,075
FY 2026

Project Title

Computational approaches to advance genomic, biological and clinical understandings of human disease

Grant Number:

5R35GM124836-09

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2017

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY / ABSTRACT The NIGMS Established Investigator (EI) R35 Maximizing Investigators’ Research Award (MIRA) proposal aims to use computational approaches to advance genomic, biological, and clinical understandings of human disease. The research program is broadly focused on three areas o...

Research Terms

<Address><Area><Award><Biological><Clinical><Clinical Data><Code><Coding System><Complex><Data><Data Set><Development><Diagnosis><Disease><Disorder><Drug Side Effects><Drug Targeting><Drugs><Electronic Health Record><Evaluation><Gene variant><Genes><Genetic><Genomics><Heterogeneity><Human><Individual><Investigators><Knowledge><Laboratories><Link><Medical><Medication><Mendelian randomization><Modern Man><NIGMS><National Institute of General Medical Sciences><Natural Selections><Penetrance><Pharmaceutical Preparations><Phenotype><Prevention><Publishing><Research><Research Design><Research Personnel><Researchers><Risk Factors><Science><Series><Statistical Methods><Study Type><Translating><Variant><Variation><allelic variant><biologic><clinical risk><data resource><developmental><disease risk><disorder risk><drug development><drug/agent><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><exome><exome sequencing><exome-seq><fitness><genetic architecture><genetic variant><genomic variant><human disease><human genomics><improved><indexing><insight><method development><novel><population based><programs><statistic methods><study design><therapeutic candidate><tool><trait><translational medicine>
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Braden Lobingier

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$429,000
FY 2026

Project Title

Endosomes as a multifunctional hub to control GPCR function

Grant Number:

2R35GM137835-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2020

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Signaling is the fundamental process by which the cell detects and responds to a changing environment. For signaling to function properly, it is necessary for the cell to regulate when and where signaling receptors function. G protein-coupled receptors (GPCRs) are an important famil...

Research Terms

<Affect><Affinity><Agonist><Biological><Biology><Biosensor><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell membrane><Cells><Chemicals><Clinic><Cytoplasmic Membrane><Drug Targeting><Drugs><Endocytosis><Endosomes><Environment><Family><Foundations><Funding><Future><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G Protein-Coupled Receptor Signaling><G-Protein-Coupled Receptors><G-Proteins><GPCR><GPCR Signaling><GTP-Binding Proteins><GTP-Regulatory Proteins><Goals><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><Health><Human><Intracellular Communication and Signaling><Location><Medication><Modeling><Modern Man><Organelles><Outcome><Pathway interactions><Pharmaceutical Preparations><Physiologic><Physiological><Plasma Membrane><Play><Population><Process><Protein Sortings><Proteins><Proteomics><Receptor Signaling><Receptor-Interacting Protein><Receptosomes><Recycling><Regulation><Regulatory Protein><Role><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Molecule><Signaling Pathway Gene><Signaling Protein><Sorting><biologic><biological sensor><biological signal transduction><drug action><drug development><drug/agent><functional genomics><genetic regulatory protein><improved><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><pharmacologic><plasmalemma><receptor expression><receptor function><regulatory gene product><response><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><trafficking>
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JOSEPH ZAIA

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$412,500
FY 2026

Project Title

Methods for measuring matrisome molecule similarity during disease processes

Grant Number:

5R35GM144090-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract: The application responds to NIGMS PAR-19-367 “Maximizing Investigators' Research Award (R35 - Clinical Trial Optional)” My research group focused initially on analytical methods for glycosaminoglycans (GAGs). These linear, sulfated polysaccharides are attached to serine res...

Research Terms

<Age><Aging><Animals><Award><Binding><Bioinformatics><Biological><Body Tissues><Brain><Brain Nervous System><Brain region><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Surface Proteins><Cell-Extracellular Matrix><Cells><Clinical Trials><Cyclicity><Cytoplasmic Granules><Data><Degenerative Neurologic Disorders><Detection><Disease><Disorder><ECM><Encephalon><Extracellular Matrix><Focus Groups><Funding><Glycans><Glycoproteins><Glycosaminoglycans><Goals><Hydrogen Oxide><Intracellular Communication and Signaling><Investigators><L-Serine><LC/MS><Malignant Neoplasms><Malignant Tumor><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Metabolic Glycosylation><Methods><Molecular><Molecular Interaction><Mucopolysaccharides><NIGMS><National Institute of General Medical Sciences><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurodevelopmental Disorder><Neurologic><Neurologic Degenerative Conditions><Neurological><Neurological Development Disorder><Peptides><Periodicity><Physiologic><Physiological><Physiology><Polysaccharides><Process><Proteins><Proteoglycan><Proteomics><Research><Research Personnel><Researchers><Rhythmicity><Sampling><Serine><Signal Transduction><Signal Transduction Systems><Signaling><Slide><Sulfate><Surface><Technology><Tissues><Water><ages><analytical method><antibody based detection><antibody detection><biologic><biological signal transduction><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><detect antibodies><detection method><detection procedure><detection technique><glycoprotein structure><glycoproteomics><glycosylation><granule><instrument><ion mobility><liquid chromatography mass spectrometry><malignancy><natural aging><neoplasm/cancer><neurodegenerative illness><neurodevelopmental disease><normal aging><normative aging><pathogen><programs>
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Dhiman Ray

UNIVERSITY OF OREGON, EUGENE, OR

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$401,285
FY 2026

Project Title

Molecular Mechanisms of Antimicrobial Resistance from Machine Learning Augmented Enhanced Sampling

Grant Number:

1R35GM162443-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/24/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT: Antimicrobial resistance threatens our ability to treat previously curable infectious diseases and may soon become a global public health crisis. The Ray group aims to understand and characterize the molecular mechanisms of antibiotic and antiviral resistance to identify potential avenues ...

Research Terms

<2019-nCoV S protein><2019-nCoV spike glycoprotein><2019-nCoV spike protein><Affect><Algorithms><Anti-viral Drug Resistance><Anti-viral Drug Resistant><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antibodies><Antigenic Determinants><Antigens><Antimicrobial Resistance><Area><Bacterial RNA><Binding><Binding Determinants><COVID-19 S protein><COVID-19 spike><COVID-19 spike glycoprotein><COVID-19 spike protein><Clinical Treatment Moab><Communicable Diseases><Communication><Computer Simulation><Computer based Simulation><Cutting edge antibiotics><DNA mutation><Descriptor><Development><Distant><Drugs><Epitopes><FMN><Flavin Mononucleotide><Free Energy><Future><Genetic Change><Genetic defect><Genetic mutation><Goals><Graph><Infectious Diseases><Infectious Disorder><Ligand Binding><Machine Learning><Medication><Miscellaneous Antibiotic><Molecular><Molecular Configuration><Molecular Conformation><Molecular Dynamics Simulation><Molecular Interaction><Molecular Stereochemistry><Monoclonal Antibodies><Mutation><Non-Polyadenylated RNA><Nucleotides><Pathway interactions><Pharmaceutical Preparations><Predisposition><Process><Proteins><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><RNA><RNA Gene Products><Research><Research Grants><Research Project Grants><Research Projects><Resistance><Resistance development><Resistant development><Riboflavin 5'-(dihydrogen phosphate)><Riboflavin 5'-Monophosphate><Riboflavin 5'-Phosphate><Riboflavin Mononucleotide><Ribonucleic Acid><Role><SARS-CoV-2 S><SARS-CoV-2 S protein><SARS-CoV-2 spike><SARS-CoV-2 spike glycoprotein><SARS-CoV-2 spike protein><Sampling><Severe acute respiratory syndrome coronavirus 2 S protein><Severe acute respiratory syndrome coronavirus 2 spike glycoprotein><Severe acute respiratory syndrome coronavirus 2 spike protein><Small RNA><Structure><Susceptibility><System><Therapeutic><Viral Antigens><Viral Drug Resistance><Viral Gene Products><Viral Gene Proteins><Viral Proteins><Work><anti-microbial resistant><computational simulation><computerized simulation><conformation><conformational><conformational conversion><conformational state><conformational transition><conformationally><conformations><coronavirus disease 2019 S protein><coronavirus disease 2019 spike glycoprotein><coronavirus disease 2019 spike protein><design><designing><developing resistance><developmental><drug candidate><drug/agent><explainable AI><explainable artificial intelligence><future antibiotics><genome mutation><immunogen><insight><interpretable AI><interpretable artificial intelligence><mAbs><machine based learning><molecular dynamics><monoclonal Abs><neural network><neutralizing antibody><new generation antibiotics><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation antibiotics><nextgen antibiotic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathogen><pathway><programs><rational design><resilience><resilient><resistance mutation><resistance to anti-microbial><resistance to anti-viral><resistant><resistant mutation><resistant to anti-viral><resistant to antimicrobial><simulation><small molecular inhibitor><small molecule><small molecule inhibitor><social role><spike proteins on SARS-CoV-2><virus antigen><virus protein>
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Michael Pluth

UNIVERSITY OF OREGON, EUGENE, OR

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$398,464
FY 2026

Project Title

Responsive and Targeted Modulation of Reactive Sulfur Species

Grant Number:

1R35GM161495-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/6/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Small gaseous molecules, such as hydrogen sulfide (H2S), carbon monoxide (CO), and nitric oxide (NO), are vital signaling molecules that regulate numerous physiological processes, including vascular biology, immune function, and stress responses. Broadening to other related ...

Research Terms

<Address><Biochemistry><Biological><Biological Chemistry><Biology><Blood Vessels><Carbon Monoxide><Cell Communication and Signaling><Cell Signaling><Cellular Immune Function><Chemicals><Chemistry><Disease><Disorder><Endogenous Nitrate Vasodilator><Endothelium-Derived Nitric Oxide><Environment><Future><Goals><Health><Human><Hybrids><Hydrogen Sulfide><Hypertension><Inflammation><Intracellular Communication and Signaling><Knowledge><Modern Man><Molecular><Mononitrogen Monoxide><Nerve Degeneration><Neuron Degeneration><Nitric Oxide><Nitrogen Monoxide><Nitrogen Protoxide><Organism-Level Process><Organismal Process><Oxidation-Reduction><Pathology><Physiologic Processes><Physiological Processes><Play><Redox><Research><Role><S element><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Sulfides><Sulfur><Therapeutic><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><biologic><biological adaptation to stress><biological signal transduction><design><designing><endothelial cell derived relaxing factor><fundamental research><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immune function><in vivo><innovate><innovation><innovative><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><next generation><oxidation reduction reaction><persulfides><polysulfide><programs><rapid growth><reactioncrisis><small molecule><social role><stress response><stressreaction><tool><translational applications><vascular>
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Xiang Cheng

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$373,737
FY 2026

Project Title

Dynamics of Motile Flagella in Fluid Media

Grant Number:

1R35GM161202-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract Flagella—motile, hair-like appendages extending from the surface of cells—are ubiquitously present across all three domains of life. These organelles carry out diverse functions of cells, including motility, sensory perception, and fluid transport, through their primary ability to move amb...

Research Terms

<3-D><3-Dimensional><3D><Address><Bacteria><Biologic Models><Biological><Biological Function><Biological Models><Biological Process><Career Choice><Career Path><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell surface><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chemotaxis><Chlamydomonas reinhardii><Chlamydomonas reinhardtii><Chlorophycota><Chlorophyta><E coli><E. coli><Elasticity><Electron Microscopy><Environment><Escherichia coli><Flagella><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Goals><Green Algae><Hair><Holography><Human><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Lead><Length><Life><Liquid substance><Maps><Measures><Mediating><Microscopy><Model System><Modeling><Modern Man><Motility><Motion><Motor><Organ><Organelles><Outcome><Pb element><Perception><Process><Property><Recombinant DNA Technology><Research><Sensory><Single Crystal Diffraction><Speed><Structure><Subcellular Process><Techniques><Time><Torque><Training><Variant><Variation><X Ray Crystallographies><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray/Neutron Crystallography><Xray Crystallography><appendage><biologic><career aspiration><career interest><career pathway><career track><ciliopathy><develop therapy><experiment><experimental research><experimental study><experiments><fluid><fluid flow><genetically engineered><heavy metal Pb><heavy metal lead><imaging><imaging capabilities><innovate><innovation><innovative><insight><intervention development><liquid><microbial><mutant><novel imaging technique><physical model><spatial and temporal><spatial temporal><spatiotemporal><stem><temporal measurement><temporal resolution><therapy development><three dimensional><time measurement><tool><treatment development>
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Xiaofei Bai

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$320,750
FY 2026

Project Title

Genetic and Molecular Mechanisms Connecting Mechanotransduction to Lipid Metabolism

Grant Number:

1R35GM162564-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Mechanotransduction and lipid metabolism are fundamental physiological processes essential for maintaining cellular and tissue integrity. Mechanotransduction enables cells to sense and respond to mechanical forces, driving tissue development, homeostasis, and adaptation. Lipid metabo...

Research Terms

<Address><Assay><Automobile Driving><Autoregulation><Bioassay><Biochemistry><Biological><Biological Assay><Biological Chemistry><Body Tissues><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Calcium Ion Signaling><Calcium Signaling><Cardiac><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Mechanotransduction><Cellular Physiology><Cellular Process><Communication><DNA mutation><Defect><Development><Dysfunction><Equilibrium><Family><Fatty Acids><Foundations><Functional disorder><Genes><Genetic><Genetic Change><Genetic Screening><Genetic defect><Genetic mutation><Goals><Health><Homeostasis><Impairment><Intracellular Communication and Signaling><Investigation><Ion Channel><Ionic Channels><Knowledge><Label><Link><Lipids><Liver><Mechanical Signal Transduction><Mechanical Stress><Mechanosensory Transduction><Mediating><Membrane Channels><Metabolic><Modeling><Molecular><Mutation><Organism-Level Process><Organismal Process><Outcome><Pathogenicity><Pathologic><Physiologic><Physiologic Processes><Physiological><Physiological Homeostasis><Physiological Processes><Physiopathology><Process><Prostaglandins><Prostanoids><Proteomics><Regulatory Pathway><Regulatory Protein><Research><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal Muscle><Stress><Subcellular Process><Therapeutic Intervention><Tissues><Toxic effect><Toxicities><Voluntary Muscle><Work><adipogenesis><balance><balance function><biologic><biological signal transduction><cell behavior><cellular behavior><developmental><driving><energy balance><fat metabolism><genetic regulatory protein><genome mutation><hepatic body system><hepatic organ system><insight><intervention therapy><lipid biosynthesis><lipid metabolism><lipogenesis><mechanical force><mechanosensing><mechanotransduction><novel><pathophysiology><regulatory gene product><social role><tool><transcriptomics><translational applications>
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ANDREA CALIFANO

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$978,890
FY 2025

Project Title

Predicting Cancer Cell Response to Endogenous and Exogenous Perturbations at the Single Cell Level

Grant Number:

5R35CA197745-11

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/14/2015

End Date:

7/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

The study of cancer has been predicated on the discovery of individual events, mechanisms, and processes that are implicated in the malignant transformation of normal cells. The expectation has been that learning how tumors arise would teach us how to defeat them, by providing pharmacologically acti...

Research Terms

<Address><Affect><Assay><Behavior><Bioassay><Biological Assay><CRISPR interference><CRISPR-dCas9-mediated repression><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Cancers><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell model><Cells><Cellular model><Clustered Regularly Interspaced Short Palindromic Repeats interference><DNA mutation><Data><Drugs><Educational process of instructing><Etiology><Event><Funding><Gene Transcription><Generations><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Goals><Human><Individual><Intervention><Intracellular Communication and Signaling><Learning><Logic><Malignant><Malignant - descriptor><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mammalian Cell><Mediating><Medication><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Mutation><Nature><Normal Cell><Organ><Pharmaceutical Preparations><Physiologic><Physiological><Population><Probabilistic Models><Probability Models><Process><Proteins><Proteome><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Reagent><Regulation><Regulatory Protein><Research><Series><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Statistical Models><Teaching><Technology><Time><Transcription><biological signal transduction><cancer cell><cancer microenvironment><causation><cell behavior><cellular behavior><computer based prediction><curative intervention><curative therapeutic><curative therapy><curative treatments><disease causation><drug/agent><expectation><forging><genetic regulatory protein><genome mutation><knock-down><knockdown><learning network><malignancy><molecular profile><molecular signature><neoplasm/cancer><network models><novel><pharmacologic><predictive modeling><programs><quantum><regulatory gene product><repressing CRISPR-dCas9 system><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><small molecule><statistical linear mixed models><statistical linear models><synergism><transcriptome sequencing><transcriptomic sequencing><transdifferentiation><tumor><tumor microenvironment><virtual>
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CRAIG M CREWS

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$976,573
FY 2025

Project Title

Inducing Proximity: An Emerging Paradigm for New Therapeutic Modalities

Grant Number:

5R35CA197589-11

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/9/2015

End Date:

8/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

The pharmaceutical industry is in a crisis; unfortunately the post-genomic era has not significantly changed the number of proteins pursued by drug companies. This dearth of new cancer drug targets has resulted in too many ‘me too’ drugs and wasted effort. To address this need, my lab has focused on...

Research Terms

<Academia><Address><Breast Cancer><Cell Culture Techniques><Clinical Trials><Development><Disease><Disorder><Drug Industry><Drug Targeting><Drug usage><Drugs><E3 Ligase><E3 Ubiquitin Ligase><FDA approved><Future><Genomics><Malignant Breast Neoplasm><Malignant neoplasm of prostate><Malignant prostatic tumor><Medication><Metabolic Protein Degradation><Modality><Multiple Myeloma><Nuclear Hormone Receptor Superfamily><Nuclear Hormone Receptors><Oncogene Products><Oncogene Proteins><Oncogenic><Oncology><Oncology Cancer><Oncoproteins><Pharmaceutic Industry><Pharmaceutical Agent><Pharmaceutical Industry><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phase><Plasma-Cell Myeloma><Play><Prostate CA><Prostate Cancer><Prostate malignancy><Proteasome Inhibitor><Protein Cleavage><Protein Turnover><Proteins><Proteolysis><Refractory><Regulatory Protein Degradation><Relapse><Research><Short interfering RNA><Small Interfering RNA><Technology><Translating><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Work><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><cell culture><cell cultures><clinical validation><developmental><drug candidate><drug development><drug use><drug/agent><first in man><first-in-human><in vivo><innovate><innovation><innovative><knock-down><knockdown><malignant breast tumor><myeloma><myelomatosis><new anti-cancer agent><new anticancer agent><new anticancer drug><new antineoplastic><new cancer drug><new drug class><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel anti-cancer agent><novel anti-cancer drug><novel anticancer agent><novel anticancer drug><novel antineoplastic><novel cancer drug><novel drug class><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pharmaceutical><protein degradation><protein homeostasis><proteostasis><recruit><siRNA><small molecule><success><translational cancer research><tumor><ubiquitin-protein ligase><wasting>
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Nuala Jennings Meyer

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$975,000
FY 2025

Project Title

Investigating Individual Susceptibility and Host Response in Acute Respiratory Distress Syndrome

Grant Number:

5R35HL161196-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/19/2022

End Date:

7/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

This R35 proposal is to support a robust translational research program focused on sepsis-associated acute respiratory distress syndrome (ARDS), explaining individual risk and characterizing the ARDS host immune response in order to identify molecular traits that may respond differently to specific ...

Research Terms

<ARDS><Acute Kidney Failure><Acute Kidney Insufficiency><Acute Renal Failure><Acute Renal Insufficiency><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Address><Admission><Admission activity><Adult ARDS><Adult RDS><Adult Respiratory Distress Syndrome><American><Area><Blood Plasma><Body System><COVID associated ARDS><COVID associated acute respiratory distress syndrome><COVID crisis><COVID epidemic><COVID induced ARDS><COVID induced acute respiratory distress syndrome><COVID pandemic><COVID related ARDS><COVID related acute respiratory distress syndrome><COVID-19 associated ARDS><COVID-19 associated acute respiratory distress syndrome><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 induced ARDS><COVID-19 induced acute respiratory distress syndrome><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 related ARDS><COVID-19 related acute respiratory distress syndrome><COVID-19 years><COVID-19/ARDS><COVID-19/acute respiratory distress syndrome><COVID/ARDS><COVID/acute respiratory distress syndrome><COVID19 associated ARDS><COVID19 associated acute respiratory distress syndrome><COVID19 induced ARDS><COVID19 induced acute respiratory distress syndrome><COVID19 related ARDS><COVID19 related acute respiratory distress syndrome><COVID19/ARDS><COVID19/acute respiratory distress syndrome><Cessation of life><Circulatory Collapse><Clinical><Cognitive><Cohort Studies><Concurrent Studies><Critical Illness><Critically Ill><DNA><Da Nang Lung><Data><Death><Delirium><Deoxyribonucleic Acid><Drug Therapy><Dysfunction><Fostering><Functional disorder><Funding><Genetic><Genomics><Goals><Health><Hereditary><Human><Immune><Immune response><Immunes><Individual><Inherited><Injury><Intensive Care><Intensive Care Units><Investigation><Investigators><Investments><Knowledge><Medicine><Mentorship><Modern Man><Molecular><NHLBI><National Heart, Lung, and Blood Institute><Non-Polyadenylated RNA><Organ System><Organ failure><Outcome><Pathway interactions><Patients><Pattern><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiopathology><Plasma><Plasma Serum><Predisposition><Prevention><Proteins><Proteomics><QTL><Quantitative Trait Loci><RNA><RNA Gene Products><Recovery><Research><Research Personnel><Researchers><Resolution><Reticuloendothelial System, Serum, Plasma><Ribonucleic Acid><Risk><SARS-CoV-2 associated ARDS><SARS-CoV-2 associated acute respiratory distress syndrome><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 induced ARDS><SARS-CoV-2 induced acute respiratory distress syndrome><SARS-CoV-2 pandemic><SARS-CoV-2 related ARDS><SARS-CoV-2 related acute respiratory distress syndrome><SARS-CoV-2/ARDS><SARS-CoV-2/acute respiratory distress syndrome><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sepsis><Sepsis and ARDS><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shock><Shock Lung><Sterility><Stiff lung><Susceptibility><Syndrome><T-Cell Activation><Techniques><Testing><Time><Training><Translational Research><Translational Research Enterprise><Translational Science><Viremia><Visualization><activate T cells><acute kidney injury><acute respiratory distress syndrome caused by sepsis><bacterial sepsis><biomed informatics><biomedical informatics><career development><circulatory shock><cohort><coronavirus disease 2019 associated ARDS><coronavirus disease 2019 associated acute respiratory distress syndrome><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 induced ARDS><coronavirus disease 2019 induced acute respiratory distress syndrome><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 related ARDS><coronavirus disease 2019 related acute respiratory distress syndrome><coronavirus disease 2019/ARDS><coronavirus disease 2019/acute respiratory distress syndrome><coronavirus disease associated ARDS><coronavirus disease associated acute respiratory distress syndrome><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease induced ARDS><coronavirus disease induced acute respiratory distress syndrome><coronavirus disease pandemic><coronavirus disease related ARDS><coronavirus disease related acute respiratory distress syndrome><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease/ARDS><coronavirus disease/acute respiratory distress syndrome><customized therapy><customized treatment><delirious><drug intervention><drug treatment><entire genome><full genome><genomic tools><host response><human subject><immune system response><immunoresponse><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><injuries><injury to organs><lung health><metabolism measurement><metabolomics><metabonomics><mortality><organ injury><pathophysiology><pathway><patient centered><patient oriented><patient specific therapies><patient specific treatment><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><predict responsiveness><predicting response><programs><pulmonary health><resolutions><response><sepsis ARDS><sepsis acute respiratory distress syndrome><sepsis and acute respiratory distress syndrome><sepsis associated acute respiratory distress syndrome><sepsis induced ARDS><sepsis induced acute respiratory distress syndrome><sepsis related acute respiratory distress syndrome><severe acute respiratory syndrome coronavirus 2 associated ARDS><severe acute respiratory syndrome coronavirus 2 associated acute respiratory distress syndrome><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 induced ARDS><severe acute respiratory syndrome coronavirus 2 induced acute respiratory distress syndrome><severe acute respiratory syndrome coronavirus 2 related ARDS><severe acute respiratory syndrome coronavirus 2 related acute respiratory distress syndrome><severe acute respiratory syndrome coronavirus 2/ARDS><severe acute respiratory syndrome coronavirus 2/acute respiratory distress syndrome><shocks><sterile><tailored medical treatment><tailored therapy><tailored treatment><trait><transcriptomics><translation research><translation research enterprise><translational investigation><translational research program><unique treatment><viraemia><viral sepsis><virusemia><wet lung><whole genome>
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Vitaly A Klyachko

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$972,416
FY 2025

Project Title

Mechanisms of Synaptic Transmission in Healthy and Disease States

Grant Number:

5R35NS111596-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2019

End Date:

4/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Direct examination of presynaptic processes has historically been limited by the resolution constraints of conventional light microscopy. As a result, much of what we know about vesicle movement, fusion, and recycling relies on inferences from indirect electrophysiological and/or biochemical assays,...

Research Terms

<ASD><Actin-Activated ATPase><Actins><Active Sites><Address><Area><Assay><Autism><Autistic Disorder><Behavior><Bioassay><Biochemical><Biological Assay><Body Tissues><Cellular Matrix><Cognition><Complex><Cytoskeletal System><Cytoskeleton><Defect><Diagnostic><Disease><Disorder><Dysfunction><Early Infantile Autism><Electrons><Electrophysiology><Electrophysiology (science)><Escalante syndrome><Fragile X><Fragile X Syndrome><Functional disorder><Funding><Goals><Heritability><Imaging technology><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Kanner's Syndrome><Knowledge><Lead><Link><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Motor><Movement><Myosin ATPase><Myosin Adenosine Triphosphatase><Myosin Adenosinetriphosphatase><Myosins><Negative Beta Particle><Negatrons><Neural Transmission><Neurobiology><Neurophysiology / Electrophysiology><Pb element><Physiopathology><Play><Process><Recycling><Renpenning syndrome 2><Research><Resolution><Role><Synapses><Synaptic><Synaptic Transmission><Synaptic Vesicles><Technology><Therapeutic><Time><Tissues><Vesicle><Visualization><Work><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><autism spectral disorder><autism spectrum disorder><autism-fragile X (AFRAX) syndrome><autistic spectrum disorder><body movement><dynamic system><dynamical system><electrophysiological><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><heavy metal Pb><heavy metal lead><innovate><innovation><innovative><intellectual and developmental disability><intracellular skeleton><light microscopy><limited intellectual functioning><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><nano meter scale><nano meter sized><nanometer scale><nanometer sized><nanoscale><neurobiological><novel><pathophysiology><postsynaptic><presynaptic><programs><resolutions><social role><spatial and temporal><spatial temporal><spatiotemporal><synapse><synergism><translational impact>
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Saumya Das

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$966,780
FY 2025

Project Title

Functional role and therapeutic targeting of exosomes and extracellular RNA biomarkers in heart failure

Grant Number:

5R35HL150807-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2020

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Despite important advances in the treatment of heart failure (HF), >50% of patients die within 5 years of diagnosis at their first hospital admission, and HF remains a leading cause of morbidity, mortality and healthcare expenditure in the United States. With the prevalence of HF expected to increas...

Research Terms

<Address><Area><Arrhythmia><Autophagocytosis><Biological Markers><Biology><Blood Plasma><Body Tissues><Cardiac><Cardiac Arrhythmia><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac infarction><Cardiocyte><Cardiovascular Diseases><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cell to Cell Communication and Signaling><Cell-Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cessation of life><Clinical><Clinical Markers><Complex><Death><Diagnosis><Disease><Disorder><Fibrosis><Grant><Health Expenditures><Heart Arrhythmias><Heart Hypertrophy><Heart Muscle Cells><Heart failure><Heart myocyte><Hospital Admission><Hospitalization><Human><Interruption><Intracellular Communication and Signaling><Investigators><Ischemia><Measures><Mediating><Mentors><Mice><Mice Mammals><Modern Man><Morbidity><Morbidity - disease rate><Murine><Mus><Myocardial Infarct><Myocardial Infarction><Non-Polyadenylated RNA><Nuclear><Pathogenesis><Patients><Performance><Phenotype><Plasma><Plasma Serum><Prevalence><Process><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Research><Research Personnel><Researchers><Reticuloendothelial System, Serum, Plasma><Ribonucleic Acid><Role><Sampling><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Time><Tissues><United States><Work><autophagy><bio-markers><biobank><biologic marker><biological signal transduction><biomarker><biorepository><cardiac failure><cardiac hypertrophy><cardiac infarct><cardiomyocyte><cardiovascular disorder><cell culture><cell cultures><chip model><chip system><clinical biomarkers><clinically actionable><clinically useful biomarkers><coronary attack><coronary infarct><coronary infarction><exosome><experiment><experimental research><experimental study><experiments><extracellular><extracellular vesicles><flexibility><flexible><health care expenditure><heart attack><heart infarct><heart infarction><high reward><high risk><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><intercellular communication><medical expenditure><mortality><mouse model><murine model><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><on a chip><on chip><organ chip><organ on a chip><organ on chip><prognostic><risk stratification><siRNA therapy><siRNA-based therapeutic><siRNA-based therapy><small molecule><social role><stratify risk><therapeutic siRNA><therapeutic small interfering RNA><therapeutic target><tool><transcriptome sequencing><transcriptomic sequencing><uptake><vesicle release><vesicular release>
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ANTONI RIBAS

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$936,000
FY 2025

Project Title

Next Generation Cancer Immunotherapies to Defeat Melanoma

Grant Number:

5R35CA197633-11

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/9/2015

End Date:

8/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY / ABSTRACT This is a Type 2 renewal application aimed at building on the progress over the initial funding period to develop new therapies for patients with melanoma and studying the mechanistic basis of response and resistance to melanoma immunotherapies. We made significant progres...

Research Terms

<Adoptive Cell Transfers><Antigen Presentation><Antigens><Antitumor Response><Area><B-raf-1><B7-H1><BRAF><BRAF gene><Back><Basal Transcription Factor><Basal transcription factor genes><Bioinformatics><Biologic Models><Biological Models><Biopsy><CD274><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas9 screen><Cell Function><Cell Line><Cell Physiology><Cell Process><CellLine><Cellular Function><Cellular Physiology><Cellular Process><Clinical><Clinical Trials><Combined Modality Therapy><Dorsum><Drug Screening><Dysfunction><Engineered Gene><Exposure to><Functional disorder><Funding><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><Immune Interferon><Immune mediated therapy><Immunologically Directed Therapy><Immunotherapy><Interferon Gamma><Interferon Type II><Knock-out><Knockout><Knowledge><MEKs><MHC Receptor><Major Histocompatibility Complex Receptor><Malignant Cell><Malignant Melanoma><Melanoma><Melanoma Cell><Melanoma patient><Methods><Model System><Multimodal Therapy><Multimodal Treatment><Network Analysis><PD-1 inhibitors><PD-L1><PD1 inhibitors><PDL-1><Pathway Analysis><Patients><Physiopathology><Programmed Cell Death 1 Ligand 1><Programmed Death Ligand 1><RAFB1><Resistance><Science><Shapes><Signal Pathway><Strains Cell Lines><Subcellular Process><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cell Antigen Receptors><T-Cell Receptor><T-Cells><T-Lymphocyte><T-cell therapeutics><T-cell transfer therapy><Testing><Transcription Factor Proto-Oncogene><Transcription factor genes><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><adoptive cell therapy><adoptive cellular therapy><anti programmed cell death protein 1 inhibitor><anti-PD-1 inhibitors><anti-PD1 inhibitors><anti-cancer immunotherapy><anti-tumor immune response><anti-tumor response><anticancer immunotherapy><cancer cell><cancer immunotherapy><check point blockade><checkpoint blockade><clustered regularly interspaced short palindromic repeats screen><combination therapy><combinatorial><combined modality treatment><combined treatment><cultured cell line><cytokine><data modeling><depository><immune check point blockade><immune checkpoint blockade><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunotherapy for cancer><immunotherapy of cancer><improved><in vivo><lFN-Gamma><loss of function mutation><model of data><model the data><modeling of the data><mouse model><multi-modal therapy><multi-modal treatment><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathophysiology><patients suffering from melanoma><patients with melanoma><pharmacologic><programmed cell death ligand 1><programmed cell death protein ligand 1><programs><protein death-ligand 1><repository><resistant><response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic T-cell platform><thymus derived lymphocyte><transcription factor><tumor><v-raf Murine Sarcoma Viral Oncogene Homolog B1>
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MICHAEL C FIORE

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$932,015
FY 2025

Project Title

Leveraging the National Cancer Institute’s Cancer Center Cessation Initiative (C3I) Program to Evaluate and Transform Smoking Cessation Treatment in Cancer Care

Grant Number:

5R35CA197573-11

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2015

End Date:

8/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Cigarette smoking is both common and undertreated among oncology patients. Although smoking is a leading cause of cancer and results in worse cancer prognoses, only half of cancer patients who smoke are offered help in quitting during cancer care, and it is unclear that the ...

Research Terms

<21+ years old><Acceleration><Adult><Adult Human><Application Context><Cancer Cause><Cancer Center><Cancer Etiology><Cancer Patient><Cancer Prognosis><Cancer Survivor><Cancer Treatment><Cancers><Caring><Data><Effectiveness><Electronic Health Record><Equity><Health><Health Care Costs><Health Costs><Intervention><Intervention Strategies><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Methods><Modification><NCI Organization><NCI-Designated Cancer Center><National Cancer Institute><Oncology><Oncology Cancer><Outcome><Patients><Policies><Primary Care><Principal Investigator><Program Effectiveness><Recovery><Research><Senior Scientist><Smoke><Smoking><Smoking Cessation Intervention><Smoking treatment><System><Treatment outcome><adulthood><anti-cancer therapy><cancer care><cancer therapy><cancer-directed therapy><cease smoking><cigarette smoking><cigarette use><clinical care><context for implementation><contextual factors><cost><cost effectiveness><demographics><design><designing><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><evidence base><experience><implementation context><implementation strategy><improved><intervention delivery><malignancy><neoplasm/cancer><participant engagement><patient engagement><practical implementation><pragmatic implementation><programs><quit smoking><smoking cessation><smoking cessation treatment><smoking therapy><stop smoking><strategies for implementation><tool><treatment program>
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Paul F. Lambert

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$930,851
FY 2025

Project Title

Defining Drivers of HPV-associated Carcinogenesis

Grant Number:

5R35CA210807-09

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

7/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Human Papillomaviruses (HPV) cause 5% of human cancers. While there are effective prophylactic HPV vaccines, their poor uptake in the US, their inaccessibility in many parts of the world where these cancers are most frequent, and the fact they do not eliminate pre-existing p...

Research Terms

<Cancer Cause><Cancer Etiology><Cancer Induction><Cancers><Disease><Disorder><Estrogens><Faculty><Funding><Generations><Genes><Genome><Goals><Grant><HPV><HPV Vaccine><HPV caused cancer><HPV driven cancers><HPV induced cancer><HPV infection><HPV malignancy><HPV+ cancer><HPV-Related Malignancy><HPV-associated cancer><HPV-associated malignancy><HPV-related cancer><Human><Human Papilloma Virus><Human Papilloma Virus Vaccine><Human Papilloma Virus-Related Malignancy><Human Papilloma Virus-Related Malignant Neoplasm><Human Papilloma Virus-associated cancer><Human Papilloma Virus-associated malignancy><Human Papilloma Virus-related cancer><Human Papillomavirus><Human papilloma virus infection><Human papillomavirus Vaccine><Human papillomavirus cancer><Human papillomavirus induced cancer><Human papillomavirus infection><Human papillomavirus malignancy><Human papillomavirus-Related Malignancy><Human papillomavirus-Related Malignant Neoplasm><Immune mediated therapy><Immunity><Immunologically Directed Therapy><Immunotherapy><Infection><Infectious Human Wart Virus><Knowledge><Learning><Long-term infection><Malignant Neoplasms><Malignant Tumor><Merkel Cells><Merkel's Receptor><Mice><Mice Mammals><Modern Man><Murine><Mus><Oncogenic Viruses><Papilloma Viruses><Papillomaviridae><Papillomavirus><Papillomavirus Infections><Pathogenesis><Polyoma><Polyoma Viruses><Polyomavirus><Position><Positioning Attribute><Process><Productivity><Public Health><Publications><Research><Resistance><Role><Scientific Publication><Scientist><Sexual Transmission><Therapeutic Estrogen><Training><Transgenic Mice><Tumor Viruses><Universities><Wisconsin><alter microbiome><animal model development><carcinogenesis><chronic infection><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><experiment><experimental research><experimental study><experiments><human papillomavirus associated malignancy><human papillomavirus caused cancer><human papillomavirus driven cancers><human papillomavirus-associated cancer><human papillomavirus-related cancer><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><innovate><innovation><innovative><insight><malignancy><medical college><medical schools><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><mouse model><murine model><neoplasm/cancer><next generation><oncogenic tumor virus><papilloma virus Infections><persistent infection><programs><prophylactic><resistant><school of medicine><sexually transmitted><social role><tumor><uptake><virology><wart virus>
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Stefan M. PULST

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$930,250
FY 2025

Project Title

Ataxin-2 complex proteins in neurodegeneration.

Grant Number:

5R35NS127253-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

4/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract This R35 proposal builds on experiments supported by a Javits R37 and a U01 CREATE Bio award and the longstanding success of the principal investigator’s group leading from mechanistic discoveries in spinocerebellar ataxias and translation to novel treatments, one of which i...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Animal Model><Animal Models and Related Studies><Animals><Apoptotic><Ataxia><Ataxy><Autophagocytosis><Award><Behavioral><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cerebellar degeneration><Cessation of life><Chemicals><Complex><Coordination Impairment><Cytoplasm><Death><Degenerative Neurologic Disorders><Deterioration><Dimensions><Disease><Disorder><Dominantly-Inherited Spinocerebellar Ataxias><Dyssynergia><Environment><Foundations><Funding><Gene Targeting><Genes><Grant><Heat shock proteins><Hereditary><Human><In Vitro><Inherited><Intracellular Communication and Signaling><Laboratories><Mediating><Modeling><Modern Man><Morphology><Motor Cell><Motor Neuron Disease><Motor Neurons><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Nutrient><Pathogenicity><Phase><Physiologic><Physiological><Poly Q><Principal Investigator><Proteins><Proteomics><Purkinje Cells><Purkinje's Corpuscles><RNA Transport><RNA metabolism><RNA-Binding Proteins><Regulation><Reproducibility><Research><Resource Sharing><Ribonucleic Acid Transport><Role><SCA2 protein><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Small RNA><Spinal><Spinocerebellar Ataxias><Spinocerebellar Atrophies><Stress><Techniques><Time><Translations><adulthood><ataxin-2><autophagy><biological signal transduction><cerebellar Purkinje cell><cerebellum degeneration><degenerative diseases of motor and sensory neurons><degenerative disorder of motor neurons><degenerative neurological diseases><diversity and inclusion><diversity and inclusivity><dosage><experiment><experimental research><experimental study><experiments><genome scale><genome-wide><genomewide><human model><in vivo><innovate><innovation><innovative><insight><model of animal><model of human><motoneuron><muscle strength><mutant><nerve cell death><nerve cell loss><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><novel><polyQ><polyglutamine><protein complex><protein function><response><small molecule><social role><spinocerebellar ataxia type 2 gene product><stress protein><success><therapeutic target><tool><transcriptomics><translation>
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Jeffrey S. Miller

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$928,524
FY 2025

Project Title

Targeting off-the-shelf iPSC-derived natural killer cells against solid tumors

Grant Number:

5R35CA283892-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

7/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

During the last 2.5 decades, I have led clinical efforts to develop novel NK cell immunotherapy strategies to treat cancer by advancing lab-based discoveries in the areas of natural killer (NK) cell and IL-15 biology. This work has been supported by a continuously funded and recently renewed NCI P01...

Research Terms

<Adoptive Transfer><Advanced Cancer><Advanced Malignant Neoplasm><Allogenic><Area><Award><B7-H3><B7H3><Biology><Blood Cells><Blood donor><Brain Neoplasia><Brain Neoplasms><Brain Tumors><CD276><CD276 gene><CMV><Cancers><Cell Body><Cell Lineage><Cells><Cellular biology><Cellular immunotherapy><Clinical><Clinical Trials><Communities><Cytomegalovirus><Cytotoxic cell><Dependence><Development><Engineering><Environment><Exposure to><Face><Funding><Genes><Glioblastoma><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Grant><HCMV><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Homing><Hypoxia><Hypoxic><IL-15><IL15><IL15 Protein><Immune><Immune mediated therapy><Immunes><Immunologically Directed Therapy><Immunotherapy><Individual><Ink><Interleukin-15><Interleukin-15 Precursor><Investigation><K lymphocyte><MGC9721><Malignant Hematologic Neoplasm><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of prostate><Malignant prostatic tumor><Methods><Minnesota><NK Cells><NK cell immune therapy><NK cell immunotherapy><NK cell therapy><NK cell treatment><NK cell-based immune therapy><NK cell-based immunotherapy><NK cell-based therapy><NK cell-based treatment><NK cellular immunotherapy><NK cellular therapy><NK immunotherapy><NK therapy><NK treatment><Natural Killer Cell Immunotherapy><Natural Killer Cells><Normal Tissue><Normal tissue morphology><Oncogenic><Output><Oxygen Deficiency><Patients><Peripheral Blood Cell><Population><Prostate CA><Prostate Cancer><Prostate malignancy><Proteins><Qualifying><Receptor Protein><Research><Salivary Gland Viruses><Solid Neoplasm><Solid Tumor><Specificity><T-Cells><T-Lymphocyte><Testing><Translating><Universities><VHH><VHH antibody><Work><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><cancer care><cell biology><cell-based immunotherapy><chimeric antigen receptor><cost><cytomegalovirus group><design><designing><developmental><directed differentiation><experience><faces><facial><glioblastoma multiforme><iPS><iPSC><iPSCs><immune cell therapy><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><interest><malignancy><migration><nanobodies><nanobody><natural killer cell based immune therapy><natural killer cell based immunotherapy><natural killer cell therapy><natural killer cell treatment><natural killer cell-based therapy><natural killer cellular therapy><natural killer therapy><neoplasm/cancer><new approaches><novel><novel approaches><novel strategies><novel strategy><overexpress><overexpression><progenitor cell gene><progenitor gene><programs><receptor><sdAb><single domain antibodies><spongioblastoma multiforme><stem cell genes><thymus derived lymphocyte><translational investigator><translational researcher><translational scientist><tumor><tumors in the brain><variable heavy chain antibody>
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RHONDA R VOSKUHL

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$922,109
FY 2025

Project Title

Neurodegeneration Underlying Distinct Disabilities in Multiple Sclerosis Using a Cell-Specific, Region-Specific, and Sex-Specific Approach

Grant Number:

5R35NS132150-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

4/30/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Multiple sclerosis (MS) is an autoimmune, neurodegenerative disease with inflammation, demyelination, axonal damage, glial activation and synaptic loss. There are relapses and permanent disabilities. Despite success of treatments targeting cells in the immune system, there is an unmet need for treat...

Research Terms

<Age><Aging><Astrocytes><Astrocytus><Astroglia><Atrophic><Atrophy><Autoimmune><Autopsy><Back><Body Tissues><Brain><Brain Nervous System><Brain region><CNS Nervous System><Cell Body><Cell Communication><Cell Interaction><Cell-to-Cell Interaction><Cells><Central Nervous System><Clinic><Clinical><Cognition><Data><Degenerative Neurologic Disorders><Demyelinations><Development><Differences between sexes><Differs between sexes><Disseminated Sclerosis><Dorsum><Drug Therapy><EAE><Encephalon><Endocrine Gland Secretion><Experimental Allergic Encephalitis><Experimental Allergic Encephalomyelitis><Experimental Autoimmune Encephalitis><Experimental Autoimmune Encephalomyelitis><Female><Four Core Genotypes><Gene Expression><Genes><Genetic><Gonadal Steroid Hormones><Gonosomes><Hormones><Hortega cell><Human><Immune system><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Inflammation><Intervention><Label><Lifelong disability><MR Imaging><MR Tomography><MRI><MRIs><MS patient><Magnetic Resonance Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mice><Mice Mammals><Microglia><Modeling><Modern Man><Multiple Sclerosis><Murine><Mus><NMR Imaging><NMR Tomography><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Nuclear Magnetic Resonance Imaging><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Pathway interactions><Permanent disability><Pharmacological Treatment><Pharmacotherapy><Phenotype><Placebos><Process><RNA Seq><RNA sequencing><RNAseq><Relapse><Relapsing-Remitting Multiple Sclerosis><Research><Secondary Progressive Multiple Sclerosis><Sex Chromosomes><Sex Differences><Sex Hormones><Sex Steroid Hormones><Sexual differences><Sham Treatment><Sight><Single-Nucleus Sequencing><Synapses><Synaptic><Therapeutic Hormone><Tissues><Translating><Validation><Vision><Walking><Woman><Zeugmatography><adult youth><age associated effects><age effect><age related effects><aged mice><aged mouse><ages><aging effect><astrocytic glia><autoimmune encephalomyelitis><axon damage><axon injury><axonal damage><axonal injury><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><cell type><comparing females and males><comparing women and men><conditional knock-out><conditional knockout><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><demyelinate><developmental><differential expression><differentially expressed><disability><disability impact><drug intervention><drug treatment><elderly mice><females compared to males><females compared with males><females versus males><females vs. males><gitter cell><glial activation><glial cell activation><gonadal steroids><impact of age><in vivo><influence of age><insular sclerosis><interest><knock-down><knockdown><male><men><mesoglia><microglial cell><microgliocyte><multiple sclerosis patient><necropsy><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><neuropathologic><neuropathological><neuropathology><neuroprotection><neuroprotective><new approaches><novel><novel approaches><novel strategies><novel strategy><old mice><optimal therapies><optimal treatments><pathway><patients with MS><patients with multiple sclerosis><people with Multiple sclerosis><perivascular glial cell><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><postmortem><pre-clinical><pre-clinical research><preclinical><preclinical research><repair><repaired><sNuc-Seq><sex><sex based differences><sex steroid><sex-dependent differences><sex-related differences><sex-specific differences><sham therapy><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><success><synapse><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><transcriptomics><trial design><validations><visual function><women compared to men><women compared with men><women versus men><women vs. men><young adult><young adult age><young adulthood><♀><♂>
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MICHAEL A CALIGIURI

BECKMAN RESEARCH INSTITUTE/CITY OF HOPE, DUARTE, CA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$886,438
FY 2025

Project Title

Human natural killer cells: Advancing biology and clinical applications

Grant Number:

2R35CA210087-08A1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/21/2017

End Date:

6/30/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The current R35 competitive renewal is revised from 2023 (Score 15). The Panel and Reviewers raised 5 “minor” (the word used in the Summary Statement) weaknesses that I addressed. I have studied the basic biology of human natural killer (NK) cells and their clinical application for c...

Research Terms

<Address><Allogenic><Authorship><Award><Biological Markers><Biology><Biotech><Biotechnology><CAR NK><Cancer Cause><Cancer Etiology><Cancer Patient><Cancer Treatment><Cancers><Cell Body><Cell Therapy><Cells><Cessation of life><Clinic><Cytotoxic cell><Death><Development><Funding><Funding Agency><Funding Source><Gastroenterology><Human><Human Biology><IL-15><IL15><IL15 Protein><Immune><Immunes><Immunity><Immunology><Institution><Interleukin-15><Interleukin-15 Precursor><Journals><K lymphocyte><Knowledge><Lymphoid Cell><MGC9721><Magazine><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant neoplasm of pancreas><Memory><Minor><Modern Man><Modification><Molecular><NK Cells><NK cell immune therapy><NK cell immunotherapy><NK cell therapy><NK cell treatment><NK cell-based immune therapy><NK cell-based immunotherapy><NK cell-based therapy><NK cell-based treatment><NK cellular immunotherapy><NK cellular therapy><NK immunotherapy><NK therapy><NK treatment><Natural Killer Cell Immunotherapy><Natural Killer Cells><Nature><Pancreas Cancer><Pancreatic Cancer><Property><Publications><Publishing><Safety><Science><Scientific Publication><Solid Neoplasm><Solid Tumor><Survival Rate><T-Cells><T-Lymphocyte><Translating><Work><anti-cancer therapy><bio-markers><biologic marker><biomarker><cancer therapy><cancer-directed therapy><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chimeric antigen receptor><chimeric antigen receptor engineered natural killer cell><chimeric antigen receptor natural killer cells><clinical applicability><clinical application><clinical efficacy><clinical translation><clinically translatable><cost effective><developmental><engineered NK cell><engineered natural killer cell><exhaustion><improved><in vivo Model><innovate><innovation><innovative><malignancy><natural killer cell based immune therapy><natural killer cell based immunotherapy><natural killer cell therapy><natural killer cell treatment><natural killer cell-based therapy><natural killer cells expressing chimeric antigen receptors><natural killer cells with chimeric antigen receptors><natural killer cellular therapy><natural killer therapy><neoplasm/cancer><new approaches><novel approaches><novel strategies><novel strategy><pancreatic cancer patients><pancreatic malignancy><patients with pancreatic cancer><thymus derived lymphocyte><trafficking><tumor>
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John Pierce Wise

UNIVERSITY OF LOUISVILLE, LOUISVILLE, KY

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$856,452
FY 2025

Project Title

Chromosome Instability Drives Metal-Induced Lung Cancer

Grant Number:

5R35ES032876-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2021

End Date:

6/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Lung cancer is the leading cause of cancer death with little improvement in survivability over many decades. Understanding and support for lung cancer have suffered from the stigma that the disease is merely a consequence of tobacco use, when in fact other agents are a major...

Research Terms

<3-D><3-Dimensional><3D><Animals><Attention><Breast Cancer><Cancer Cause><Cancer Causing Agents><Cancer Etiology><Cancers><Carcinogens><Cell Body><Cell Line><CellLine><Cells><Cessation of life><Chromosomal Instability><Chromosome Instability><Collection><Colon Cancer><Colon Carcinoma><Complex><Cr(VI)><Death><Disease><Disorder><Environmental Health><Environmental Health Science><Epithelium><Event><Fibroblasts><Funding><Genotoxins><Health><Heritability><Human><Individual><Lung><Lung Respiratory System><Malignant Breast Neoplasm><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Malignant neoplasm of prostate><Malignant prostatic tumor><Metal Carcinogenesis><Metal exposure><Metals><Minority><Modern Man><Mutagens><Neoplastic Cell Transformation><Oncogens><Outcome><Persons><Population><Prostate CA><Prostate Cancer><Prostate malignancy><Public Health><Pulmonary Cancer><Pulmonary malignant Neoplasm><Risk Assessment><Strains Cell Lines><Tobacco><Tobacco Consumption><Tobacco use><Translating><United States><cancer in the colon><carcinogenicity><cell type><chromium hexavalent ion><chromium(VI)><cultured cell line><exposure to metal><genotoxic agent><hexavalent chromium><human subject><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><interest><lung cancer><malignancy><malignant breast tumor><mixed cell culture><neoplasm/cancer><neoplastic><neoplastic transformation><new approaches><novel><novel approaches><novel strategies><novel strategy><oncogenic agent><prevent><preventing><progenitor cell model><progenitor model><programs><social stigma><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stigma><three dimensional><tobacco product use><tobacco user><tool>
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Paul Wesley Noble

CEDARS-SINAI MEDICAL CENTER, LOS ANGELES, CA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$847,538
FY 2025

Project Title

Molecular Regulation of Progressive Pulmonary Fibrosis

Grant Number:

5R35HL150829-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2020

End Date:

2/28/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Our laboratory has been focused on elucidating the molecular mechanisms that regulate progressive pulmonary fibrosis for over two decades. My contributions to the field of idiopathic pulmonary fibrosis research include using matrix hyaluronan as a model molecule to dissect the molecular mec...

Research Terms

<Alveoli progenitor><Alveoli stem cell><Award><Awareness><Belief><Biology><CD44><CD44 Adhesion Receptor><CD44 Antigens><CD44 gene><CD44 molecule><Cell Body><Cells><Drug Targeting><Drugs><Epithelium><Fibroblasts><Fibrosing Alveolitis><Fibrosis><Freedom><Funding><Glues><Goals><HUTCH-1><Hermes Antigen><Hyaluronan><Hyaluronan Receptors><Hyaluronan-Binding Protein><Hyaluronic Acid Binding Protein><Impairment><Journals><Knowledge><Laboratories><Liberty><Lung><Lung Inflammation><Lung Respiratory System><Lung Tissue Fibrosis><MDU3><Magazine><Medication><Mesenchymal><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Pathogenicity><Patients><Pgp1><Pharmaceutical Preparations><Phenotype><Pneumonitis><Publishing><Pulmonary Fibrosis><Pulmonary Inflammation><Regenerative capacity><Regulation><Research><Role><Science><Scientist><Therapeutic Intervention><Time><Training><Universities><Work><alveolar progenitor><alveolar stem cell><arrestin B><beta-arrestin><diffuse interstitial pulmonary fibrosis><drug/agent><fibrosis in the lung><gp85><idiopathic pulmonary fibrosis><interest><intervention therapy><lung fibrosis><lung progenitor><lung stem cell><lung tissue stem cell><lung-specific stem cell><man><next generation><progenitor cell division><progenitor cell regeneration><progenitor cell renewal><progenitor cell self renewal><progenitor cells in the lung><progenitor division><progenitor regeneration><progenitor renewal><progenitor self renewal><progenitors in the lung><pulmonary progenitor><pulmonary stem cell><regeneration ability><regeneration capacity><social role><stem and progenitor cell division><stem and progenitor cell regeneration><stem and progenitor cell renewal><stem and progenitor cell self renewal><stem cell division><stem cell regeneration><stem cell renewal><stem cell self renewal><stem cells in the lung><therapeutic agent development><therapeutic development><β-arrestin>
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Alan Daugherty

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$839,592
FY 2025

Project Title

Determinants of Aorta Heterogeneity

Grant Number:

5R35HL155649-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2021

End Date:

5/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Aortopathies, including aneurysms, dissection, and rupture, represent a key challenge in HLBS research. In the past twenty years of our continuously funded research on aortopathies, we have contributed to many mechanistic insights into the aortopathy research including a new concept: There ...

Research Terms

<ASCVD><Affect><Aneurysm><Aorta><Aortic Diseases><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Basic Research><Basic Science><Biological><Biology><Body Tissues><Brain><Brain Nervous System><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell-Extracellular Matrix><Cells><Cellular Function><Cellular Physiology><Cellular Process><Characteristics><Clinical><Data><Disease><Disorder><Dissection><Drugs><ECM><Echography><Echotomography><Embryo><Embryonic><Encephalon><Extracellular Matrix><Funding><Heterogeneity><Inflammation><Intermediary Metabolism><Kidney><Kidney Urinary System><Length><Life><Lipoproteins><Lung><Lung Respiratory System><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medical Ultrasound><Medication><Metabolic Processes><Metabolism><Molecular><NMR Imaging><NMR Tomography><Nuclear Magnetic Resonance Imaging><Operative Procedures><Operative Surgical Procedures><Organ><Pathogenesis><Patient Observation><Pharmaceutical Preparations><Proteomics><Reagent><Research><Rupture><Scientist><Signal Pathway><Skin><Specificity><Subcellular Process><Surgical><Surgical Interventions><Surgical Procedure><Syndrome><Techniques><Therapeutic><Tissues><Training><Translational Research><Translational Science><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><Watchful Waiting><Zeugmatography><aortic disorder><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><biologic><bone><diagnostic ultrasound><drug/agent><extracellular><flexibility><flexible><insight><intra-vital microscopy><intravital microscopy><mouse model><murine model><next generation><novel><programs><renal><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><sonogram><sonography><sound measurement><surgery><tool><transcriptomics><translation research><translational investigation><ultrasound imaging><ultrasound scanning>
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Wen Xie

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$814,679
FY 2025

Project Title

Xenobiotic Receptors in Mediating the Environmental Effects on Human Disease and Morbidity

Grant Number:

5R35ES030429-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2019

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Title: Xenobiotic Receptors in Mediating the Environmental Effects on Human Disease and Morbidity Project Summary/Abstract: This R35 proposal is designed to consolidate our current NIEHS funded projects into one program with the focus on understanding the role of xenobiotic receptors in regulating t...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><AH Receptors><Alcoholic Liver Diseases><Aryl Hydrocarbon Receptor><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Behavior><Cell Communication and Signaling><Cell Signaling><Chemical Exposure><Chemicals><Chronic Disease><Chronic Illness><Dioxin Receptors><Disease><Disorder><Dysfunction><Environment><Environmental Factor><Environmental Risk Factor><Enzyme Gene><Enzymes><Exposure to><Extrahepatic><Fibrosis><Freedom><Functional disorder><Funding><Gene Action Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene x Environment Interaction><General Transcription Factor Gene><General Transcription Factors><Genetic><Goals><Grant><GxE interaction><Health><Hepatic><Hepatic Tissue><Homeostasis><Human><Intervention Strategies><Intracellular Communication and Signaling><KO mice><Knock-out Mice><Knockout Mice><Lead><Liberty><Ligands><Mediating><Mediator><Metabolic syndrome><Modern Man><NIEHS><National Institute of Environmental Health Sciences><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Nuclear Receptors><Nuclear Translocator><Null Mouse><Outcome><PXR receptor><Pathogenesis><Pathogenicity><Pathway interactions><Pb element><Physiological Homeostasis><Physiology><Physiopathology><Play><Polyaromatic Hydrocarbon Receptors><Population><Preventative strategy><Prevention strategy><Preventive strategy><Principal Investigator><Receptor Protein><Regulation><Risk><Role><Scientist><Seminal><Sight><Signal Transduction><Signal Transduction Systems><Signaling><TCDD Receptors><Testing><Therapeutic><Toxicology><Transcription Factor Proto-Oncogene><Transcription factor genes><Vision><Xenobiotic Metabolism><Xenobiotics><alcohol induced hepatic injury><alcohol induced liver disorder><alcohol induced liver injury><alcohol related liver disease><alcohol-associated liver disease><alcohol-induced hepatic dysfunction><alcohol-induced liver disease><alcohol-induced liver dysfunction><alcohol-mediated liver dysfunction><alcohol-mediated liver injury><alcohol-related liver disease><alcoholic liver injury><biological signal transduction><chronic disorder><constitutive androstane receptor><design><designing><environment effect on gene><environmental chemical><environmental risk><ethanol induced hepatic injury><ethanol induced liver disorder><ethanol induced liver injury><ethanol liver disease><ethanol-induced hepatic dysfunction><ethanol-induced liver disease><ethanol-induced liver dysfunction><ethanol-mediated liver dysfunction><ethanol-mediated liver injury><experience><gene environment interaction><heavy metal Pb><heavy metal lead><human disease><human morbidity><insight><intervention design><knockout gene><neurological disease><pathophysiology><pathway><pharmacologic><pregnane X receptor><programs><receptor><social role><therapeutic target><therapy design><tool><transcription factor><treatment design><visual function>
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John A. Tainer

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$814,230
FY 2025

Project Title

Mesoscale and Nanoscale Technologies Integrated by Structures for DNA Repair Complexes (MANTIS-DRC)

Grant Number:

2R35CA220430-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/13/2018

End Date:

8/31/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Cancer is linked to every human DNA repair (DR) pathway. Genomic instability, which results from DR defects, is a cancer hallmark. Due to cancer cell susceptibilities from oncogenic stress and frequent DR defects, DNA damaging approaches are widely used successful cancer the...

Research Terms

<Address><Advanced Cancer><Advanced Malignant Neoplasm><Aging><Alkylation><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Biological><Cancer Biology><Cancer Cause><Cancer Drug><Cancer Etiology><Cancer Patient><Cancer Treatment><Cancers><Cell Body><Cells><Cellular biology><Clinical><Complex><DNA><DNA Damage><DNA Damage Repair><DNA Double Strand Break><DNA Injury><DNA Repair><DNA Repair Pathway><DNA Structure><DNA mutation><DNA replication fork><Data><Data Analyses><Data Analysis><Data Bases><Data Correlations><Data Set><Databases><Defect><Deoxyribonucleic Acid><Dissection><Drug Targeting><Exposure to><Genetic Change><Genetic defect><Genetic mutation><Genome Instability><Genomic Instability><Immune mediated therapy><Immunologically Directed Therapy><Immunotherapy><Innate Immune Response><Kinetics><Knowledge><Link><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Maps><Measurement><Medicine><Mitochondria><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Mutation><NADH><Neoplastic Disease Chemotherapeutic Agents><Non-Polyadenylated RNA><Oncogenic><Outcome><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phenotype><Predisposition><Production><RNA><RNA Gene Products><Repair Complex><Ribonucleic Acid><Roentgen Rays><Second Cancer><Second Primary Cancers><Secondary Malignancy><Secondary Malignant Neoplasm><Stress><Structure><Susceptibility><System><Technology><Testing><Time><Toxic effect><Toxicities><Tumor-Specific Treatment Agents><Unscheduled DNA Synthesis><X-Radiation><X-Ray Radiation><X-ray><Xray><anti-cancer drug><anti-cancer therapy><biologic><cancer cell><cancer cell genome><cancer genome><cancer therapy><cancer-directed therapy><cell biology><combat><complex data><conformation><conformational><conformational state><conformationally><conformations><data base><data interpretation><design><designing><entire genome><full genome><genome mutation><human DNA><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><individualized cancer care><individualized oncology><inhibitor><insight><malignancy><mitochondrial><nano meter scale><nano meter sized><nanometer scale><nanometer sized><nanoscale><neoplasm/cancer><pathway><patient oriented outcomes><personalized oncology><precision cancer care><precision cancer medicine><precision oncology><repair><repaired><replication fork><resistance to therapy><resistant to therapy><response><secondary cancer><side effect><synthetic lethal interaction><synthetic lethality><therapeutic resistance><therapy resistant><tool><treatment resistance><tumor genome><whole genome>
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Zhen Bouman Chen

BECKMAN RESEARCH INSTITUTE/CITY OF HOPE, DUARTE, CA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$813,786
FY 2025

Project Title

RNA-mediated endotheliopathy in diabetic vasculopathy

Grant Number:

5R35HL171550-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

6/30/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary More than 10% of the global adult population currently lives with diabetes mellitus (DM) and are experiencing or at higher risk for various diabetic vasculopathies such as peripheral artery disease (PAD). Despite available treatment, many patients with DM continue to develop diabeti...

Research Terms

<21+ years old><Address><Adult><Adult Human><Automobile Driving><Award><Biology><Blood Vessels><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Chromatin><DNA Therapy><Development><Diabetes Mellitus><Disease><Disorder><Endothelial Cells><Endothelium><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Functional RNA><Funding><Gene Transfer Clinical><Genetic Intervention><Goals><Impairment><Investigators><Knowledge><Mediating><Mediator><Medical><Memory><Metabolic><Metabolic Diseases><Metabolic Disorder><MicroRNAs><Mission><Modification><NHLBI><National Heart, Lung, and Blood Institute><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Pain><Painful><Patients><Peripheral arterial disease><Play><Population><Predisposition><RNA><RNA Gene Products><Research><Research Personnel><Researchers><Ribonucleic Acid><Role><Sight><Subcellular Process><Susceptibility><Testing><Therapeutic><Thesaurismosis><Untranslated RNA><Vascular Diseases><Vascular Disorder><Vascular regeneration><Vision><adulthood><blood vessel disorder><determine efficacy><developmental><diabetes><diabetic><driving><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><endothelial dysfunction><epigenetic memory><epigenetically><epigenome><epitranscriptome><evaluate efficacy><examine efficacy><experience><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><high risk><innovate><innovation><innovative><innovative technologies><insight><metabolism disorder><miRNA><nano medicinal><nano medicine><nano particle><nano-sized particle><nanomedicinal><nanomedicine><nanoparticle><nanosized particle><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><noncoding><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><peripheral artery disease><restoration><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><vascular><vascular dysfunction><vascular inflammation><vasculopathy><visual function>
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JEFFREY J GRAY

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$790,197
FY 2025

Project Title

Prediction of the Structures of Protein Complexes

Grant Number:

5R35GM141881-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2021

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Prediction of the Structures of Protein Complexes Jeffrey J. Gray, NIGMS R35 (MIRA) PROJECT SUMMARY Protein interactions are involved in nearly all biological processes in human health and diseases, and protein complex structures can reveal biological mechanisms and suggest intervention strategies. ...

Research Terms

<3-D structure><3-dimensional structure><3D structure><Antibodies><Antigens><Area><Binding><Binding Proteins><Biological><Biological Function><Biological Process><Biophysics><Cancers><Carbohydrates><Collaborations><Communicable Diseases><Complex><Computer Models><Computer software><Computerized Models><Computing Methodologies><Designing computer software><Development><Diagnostic><Disease><Disorder><Docking><Drugs><Engineering><Glycans><Health><Human><Immunology><Individual><Industry><Infectious Diseases><Infectious Disorder><Infrastructure><International><Intervention Strategies><Lead><Ligand Binding Protein><Ligand Binding Protein Gene><Macromolecular Structure><Malignant Neoplasms><Malignant Tumor><Medication><Methods><Modeling><Modern Man><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Molecular Structure><NIGMS><National Institute of General Medical Sciences><Pb element><Pharmaceutical Preparations><Polysaccharides><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Protein Binding><Protein Conformation><Protein Engineering><Protein Modification><Proteins><Resolution><Route><Scheme><Scientist><Software><Software Design><Structure><Teaching Materials><Testing><Tissue Engineering><Training><Work><bioengineered tissue><biologic><biophysical foundation><biophysical principles><biophysical sciences><bound protein><computational methodology><computational methods><computational modeling><computational models><computer based method><computer based models><computer methods><computerized modeling><computing method><conformation><conformational><conformational state><conformationally><conformations><design><designing><developmental><drug mechanism><drug/agent><engineered tissue><genetic protein engineering><heavy metal Pb><heavy metal lead><immunogen><innovate><innovation><innovative><insight><malignancy><modulator protein><neoplasm/cancer><operation><operations><phosphatase inhibitor 2><phosphoprotein phosphatase inhibitor-2><polypeptide><protein complex><protein design><protein function><protein phosphatase inhibitor-2><protein protein interaction><protein structure prediction><resolutions><scripting interface><synergism><teacher materials><three dimensional structure><tool><web interface><web server>
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JOHN A. PORCO

BOSTON UNIVERSITY (CHARLES RIVER CAMPUS), BOSTON, MA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$702,900
FY 2025

Project Title

Chemical Synthesis of Complex Natural Products for Translational Science

Grant Number:

5R35GM118173-10

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2016

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Chemical Synthesis of Complex Natural Products for Translational Science The goals of the continuing MIRA (R35GM118173) research program are to continue focus on chemical syntheses of bioactive molecules for translational studies. The MIRA effort will allow flexibility and stability ...

Research Terms

<9-Oxoxanthene><Address><Alkaloids><Biological><Biological Mimetics><Biomimetics><Cancers><Catalysis><Clinical><Clinical Research><Clinical Study><Collaborations><Complex><Development><Drug Therapy><Goals><Human><Investigation><Investigators><Ions><Journals><Magazine><Malignant Neoplasms><Malignant Tumor><Manuscripts><Methodology><Methods><Modern Man><Natural Products><Organic Chemistry><Pharmacological Treatment><Pharmacotherapy><Principal Investigator><Productivity><Property><Public Health><Publications><Pyrrolo-Iminoquinones><Pyrroloiminoquinones><Reaction><Research><Research Personnel><Researchers><Scientific Publication><Translational Research><Translational Science><Translations><Trichothecenes><Viral><Work><Xanthones><bioactive natural products><biologic><chemical synthesis><cycloaddition><developmental><dimer><drug intervention><drug treatment><flexibility><flexible><inhibitor><innovate><innovation><innovative><malignancy><naturally occurring product><neoplasm/cancer><novel><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><professor><programs><translation><translation research><translational investigation><translational study>
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Julie A. Bastarache

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$702,140
FY 2025

Project Title

Applying Innovative Lung Mapping Strategies to Understand Alveolar Capillary Barrier Permeability in ARDS

Grant Number:

5R35HL150783-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2020

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary This R35 application describes a robust research framework to facilitate discovery and translation of new therapeutic targets in Acute Respiratory Distress Syndrome (ARDS), a common cause of acute respiratory failure that carries a high mortality rate and has no beneficial targeted t...

Research Terms

<ARDS><Acute><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Acute respiratory failure><Adult ARDS><Adult RDS><Adult Respiratory Distress Syndrome><Affect><Alveolar><American><Biologic Models><Biological Models><Blood capillaries><Body Tissues><Catalogs><Cell Body><Cells><Clinical Trials><Coupled><Da Nang Lung><Death Rate><Development><Disease><Disorder><Dysfunction><Expression Signature><Functional disorder><Future><Gene Expression Profile><Goals><Health><Human><Impairment><In Vitro><Institution><Laboratories><Life><Lung><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lung damage><Maps><Mediator><Methods><Mice><Mice Mammals><Mission><Model System><Modeling><Modern Man><Molecular><Murine><Mus><NHLBI><National Heart, Lung, and Blood Institute><Pathogenesis><Pathologic><Pathology><Patients><Permeability><Phenotype><Physiopathology><Pre-Clinical Model><Preclinical Models><Preclinical data><Proteins><Research><Research Resources><Resources><Sepsis><Shock Lung><Statistical Methods><Stiff lung><Structure of parenchyma of lung><Testing><Tissues><Transgenic Model><Transgenic Organisms><Translating><Translational Research><Translational Science><Translations><capillary><catalog><clinical relevance><clinically relevant><cost><design><designing><developmental><flexibility><flexible><gene expression pattern><gene expression signature><human model><imaging mass spectrometry><in vivo><injured><innovate><innovation><innovative><insight><lung injury><mass spectrometric imaging><model of human><mortality rate><mortality ratio><mouse model><murine model><new approaches><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel approaches><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><pathophysiology><pre-clinical study><preclinical findings><preclinical information><preclinical study><programs><protein expression><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><statistic methods><systems research><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><transcriptional profile><transcriptional signature><transgenic><transgenic trait><translation><translation research><translational investigation><wet lung>
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Xiling Shen

TERASAKI INSTITUTE FOR BIOMEDICAL INNOVATION, Woodland Hills, CA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$681,990
FY 2025

Project Title

Probing Tissue Heterogeneity and Stem Cell Niche with Micro-Organospheres

Grant Number:

5R35GM122465-09

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2017

End Date:

8/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Stem cells self-renew and differentiate into various cell lineages to sustain tissue homeostasis and functions. Most tissue microenvironments comprise multiple components, including epithelial, stromal, immune, and endothelial cells, that interact with each other to coordinate response to i...

Research Terms

<21+ years old><Adult><Adult Human><Autoregulation><Basic Research><Basic Science><Body Tissues><Cell Body><Cell Communication><Cell Interaction><Cell Lineage><Cell-to-Cell Interaction><Cells><Characteristics><Chimera><Chimera organism><Communities><Development><Endothelial Cells><Engraftment><Epithelium><Generalized Growth><Growth><Heterogeneity><High Throughput Assay><Homeostasis><Immune><Immunes><Lead><Microbe><Pb element><Physiological Homeostasis><Process><Progenitor Cells><Research><Research Technics><Research Techniques><Stimulus><Techniques><Tissue Growth><Tissues><adult progenitor><adult stem cell><adulthood><cell type><chimeras><combinatorial><deep learning algorithm><developmental><fundamental research><heavy metal Pb><heavy metal lead><high throughput screening><host microbe association><host microbe relationship><host-microbe interactions><host-microbial interactions><host-microorganism interactions><in vitro Model><indexing><intra-vital imaging><intravital imaging><ontogeny><progenitor cell differentiation><progenitor cell function><progenitor cell niche><progenitor differentiation><progenitor function><progenitor niche><response><self renewing cell><self-renew><self-renewal><somatic progenitor><somatic stem cell><stem and progenitor cell function><stem and progenitor cell niche><stem and progenitor differentiation><stem and progenitor function><stem cell differentiation><stem cell function><stem cell niche><stem cells><success><tool>
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Rafael Angel Irizarry

DANA-FARBER CANCER INST, BOSTON, MA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$620,001
FY 2025

Project Title

Data Analysis Tools for Emerging High-throughput Technologies

Grant Number:

2R35GM131802-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2019

End Date:

5/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Biomedical research and basic sciences are increasingly dependent on high-throughput technologies capable of simultaneously measuring thousands of nucleic acid molecules within a sample. As the use of these methods increases, the resulting complex datasets require the development of ...

Research Terms

<Address><Adoption><Advanced Development><Affect><Algorithms><Area><Basic Research><Basic Science><Biological><Biomedical Research><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Collaborations><Communities><Computational toolkit><Computer software><DNA Sequence Analyses><DNA Sequence Analysis><Data Analyses><Data Analysis><Data Set><Detection><Disease><Disorder><Ensure><Fostering><Foundations><Funding Mechanisms><Future><Gene Expression><Genetic Diversity><Genetic Variation><Genomics><Intracellular Communication and Signaling><Investigators><Measurement><Measures><Methodology><Methods><Molecular><Noise><Nucleic Acids><Outcome><Population Surveillance><Productivity><Public Health><Public Health Surveillance><Research><Research Personnel><Researchers><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Scientist><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Signal Transduction><Signal Transduction Systems><Signaling><Software><Statistical Methods><Techniques><Technology><Work><biologic><biological signal transduction><cell type><complex data><computational toolbox><computational tools><computational toolset><computerized data processing><computerized tools><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><data interpretation><data processing><dimension reduction><dimensionality reduction><flexibility><flexible><high throughput technology><improved><innovate><innovation><innovative><insight><interest><open source><reduce data dimension><reduce dimensionality><scRNA sequencing><scRNA-seq><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><statistic methods><success><tool>
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ETHAN LEE

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$562,675
FY 2025

Project Title

Maximizing Investigators' Research Award (R35 - Clinical Trial Optional)

Grant Number:

5R35GM122516-09

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2017

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY: The evolutionarily conserved Wnt pathway plays a critical role during metazoan development and stem cell maintenance in the adult. Mutations in the Wnt pathway leading to its misregulation in humans have been shown to contributes to both developmental defects and cancers. In the lat...

Research Terms

<21+ years old><Adult><Adult Human><Agonist><Award><Behavior><Biochemical><Biological Function><Biological Process><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clinical Trials><Colorectal Cancer><Compensation><Complex><DNA mutation><Defect><Development><Disease><Disorder><Drug Targeting><Drugs><E3 Ligase><E3 Ubiquitin Ligase><Embryo Development><Embryogenesis><Embryonic Development><FDA approved><Familial Adenomatous Polyposis Syndrome><Familial Polyposis Syndrome><Gene Transcription><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Goals><Human><Intracellular Communication and Signaling><Investigators><Malignant Neoplasms><Malignant Tumor><Math Models><Mediating><Medication><Modeling><Modern Man><Molecular><Mutation><Nuclear><Orphan Drugs><Pathway interactions><Pharmaceutical Preparations><Play><Proteins><RNA Expression><Receptor Activation><Receptor Protein><Regulation><Research><Research Personnel><Researchers><Role><Signal Transduction><Signal Transduction Systems><Signaling><System><Transcription><Tumor Suppressor Proteins><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><WNT Signaling Pathway><WNT signaling><Work><Xenopus><Xenopus sp.><adult progenitor><adult stem cell><adulthood><biological signal transduction><cancer initiation><clawed frog><de-ubiquitinase><de-ubiquitinating enzyme><developmental><drug/agent><egg><familial adenomatous polyposis><familial polyposis><genome mutation><malignancy><mathematic model><mathematical model><mathematical modeling><mutant><neoplasm/cancer><pathway><precancer><precancerous><premalignant><progenitor cell maintenance><progenitor maintenance><protein purification><receptor><reconstitute><reconstitution><small molecular inhibitor><small molecule inhibitor><social role><somatic progenitor><somatic stem cell><stem cell maintenance><tumor suppressor><ubiquitin isopeptidase><ubiquitin-protein ligase><ubiquitin-specific isopeptidase>
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Gino Cingolani

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$548,856
FY 2025

Project Title

Mechanism of Viral Genome Delivery into Cells

Grant Number:

5R35GM140733-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2021

End Date:

5/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Nearly 120 years since the discovery of the first virus, our understanding of how viruses deliver genomes into cells overcoming the complexity of biological membranes remains limited. While a vast scientific literature exists on viral surface proteins and their interaction with host ...

Research Terms

<Bacteria><Bacteriophages><Biological><Biological Function><Biological Process><Biology><Biotech><Biotechnology><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Nucleus Active Transport><Cell Signaling><Cells><Complex><Creativeness><Cryo-electron Microscopy><Cryoelectron Microscopy><DNA><Deoxyribonucleic Acid><Development><Electron Cryomicroscopy><Eukaryotic Cell><Funding Mechanisms><GTP Phosphohydrolases><GTPases><Genome><Gram-Negative Bacteria><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Herpesviridae><Herpesviruses><Human><Immune system><Importins><Injections><Intracellular Communication and Signaling><Laboratories><Literature><Mediating><Medicine><Membrane><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Modern Man><Molecular><Molecular Machines><NPC><Nuclear Import><Nuclear Pore Complex><Nuclear Transport><Nucleocytoplasmic Shuttling><Nucleus><Organelles><Phages><Principal Investigator><Process><Protein Biochemistry><Protein/Amino Acid Biochemistry><Publications><Receptor Protein><Regulation><Research><Running><Science><Scientific Publication><Signal Transduction><Signal Transduction Systems><Signaling><Single Crystal Diffraction><Structure><Surface Proteins><Viral><Viral Genome><Virulence><Virus><Visualization><Work><X Ray Crystallographies><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray/Neutron Crystallography><Xray Crystallography><bacterial virus><biologic><biological signal transduction><cell envelope><creativity><cryo-EM><cryoEM><cryogenic electron microscopy><developmental><genetic information><guanosinetriphosphatase><herpes virus><interest><macromolecule><membrane structure><nano machine><nanomachine><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><nucleocytoplasmic transport><pressure><programs><receptor><structural biology><virus genome>
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Hien M Nguyen

WAYNE STATE UNIVERSITY, DETROIT, MI

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$524,144
FY 2025

Project Title

Development of Catalytic Glycosylations and Biologically Important Glycosaminoglycans

Grant Number:

5R35GM149213-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

8/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The work in this proposal builds on our expertise in catalytic stereoselective glycosylations to result in efficient synthetic methodologies for construction of the challenging glycosidic bonds. We recently discovered that readily available phenanthrolines, rigid and planar organic c...

Research Terms

<Alcohol Chemical Class><Alcohols><Aminoglycosides><Benzene><Benzol><Benzole><Biological Function><Biological Process><Bromides><Cancer Treatment><Cancers><Carbohydrates><Clinical><Coupling><Cyclohexatriene><Cysteine><DNA Synthesis Factor><Development><Endothelial Cell Growth Factor><FGF><Fibroblast Growth Factor><Fibroblast Growth Factor Gene Family><Fibroblast Growth Regulatory Factor><Glycopeptides><Glycosaminoglycans><Glycosides><Grant><Half-Cystine><Heparan Sulfate><Heparanase inhibitors><Heparitin Sulfate><Hydroxyl><Hydroxyl Radical><L-Cysteine><L-Serine><Libraries><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mercaptans><Mercapto Compounds><Metabolic Glycosylation><Methodology><Methods><Mucopolysaccharides><Multiple Myeloma><Neural Development><O element><O2 element><Oligosaccharides><Oxygen><PSGAG><Peptides><Phenanthrolines><Plasma-Cell Myeloma><Reaction><Role><Serine><Site><Sulfate><Sulfhydryl Compounds><System><Thiols><Work><anti-cancer therapy><anti-heparanase drugs><biological systems><cancer therapy><cancer-directed therapy><catalyst><developmental><druggable target><functional group><glycosaminoglycan polysulfate><glycosaminoglycan polysulfuric acid ester><glycosaminoglycan polysulphate><glycosylation><malignancy><mimetics><myeloma><myelomatosis><neoplasm/cancer><neurodevelopment><polyol><polysulfated glycosaminoglycan><pyridine><social role><sulfated glycosaminoglycan><sulfhydryl group>
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Nicholas P Tatonetti

CEDARS-SINAI MEDICAL CENTER, LOS ANGELES, CA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$501,000
FY 2025

Project Title

Precision Pharmacology and Pharmacovigilance: Leveraging AI to address drug safety knowledge gaps

Grant Number:

2R35GM131905-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2019

End Date:

7/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

I am proposing to continue my research program in precision pharmacology and pharmacovigilance coupling observational data analysis with recent advancements in artificial intelligence to advance drug safety and efficacy. Over the past five years, the availability of observational data via electronic...

Research Terms

<AI system><Active Follow-up><Address><Adverse drug event><Adverse effects><Affect><Area><Artificial Intelligence><Biological><Cell Communication and Signaling><Cell Signaling><Child Development><Childhood><Clinical Data><Clinical Trials><Complement><Complement Proteins><Complex><Computer Reasoning><Coupling><Data><Data Analyses><Data Analysis><Data Bases><Data Science><Databases><Drug Design><Drug Interactions><Drug Side Effects><Drug toxicity><Drugs><Effectiveness><Electronic Health Record><Ensure><Epidemiology><Frequencies><Future><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Goals><Health><Infant and Child Development><Informatics><Inherited Predisposition><Inherited Susceptibility><Institution><Intervention><Intracellular Communication and Signaling><Investigators><Knowledge><Lead><Length of Life><Longevity><Machine Intelligence><Machine Learning><Medication><Medicine><Modeling><Molecular><Outcome><Paper><Patients><Pb element><Pharmaceutical Preparations><Pharmacology><Public Health><Reaction><Research><Research Personnel><Researchers><Safety><Severities><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Structure><Symptoms><Validation><Work><active followup><adverse drug reaction><age associated><age correlated><age dependent><age linked><age related><age specific><biobank><biologic><biological signal transduction><biorepository><complementation><customized therapy><customized treatment><data base><data interpretation><digital health><drug efficacy><drug safety><drug/agent><effective therapy><effective treatment><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><epidemiologic><epidemiological><experience><experiment><experimental research><experimental study><experiments><follow up><follow-up><followed up><followup><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><heavy metal Pb><heavy metal lead><improved><individual patient><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><insight><invention><machine based learning><medication safety><multi-modality><multimodality><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><patient specific therapies><patient specific treatment><pediatric><pharmaceutical safety><pharmacovigilance><precision medicine><precision-based medicine><programs><safety study><tailored medical treatment><tailored therapy><tailored treatment><unique treatment><validations>
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RUMA V BANERJEE

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 52/100
Likely hiring
Solid budget
Active award
$485,057
FY 2026

Project Title

Sulfide metabolism and signaling

Grant Number:

5R35GM130183-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2019

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

The liminal zone between host epithelium and gut microbiota is rich in sulfide conversations that are modulated by diet; their short- and long-range impacts on systemic H2S homeostasis represent a largely unexplored terrain ripe for discovery. The toxicity of H2S, first described as a noxious “acidi...

Research Terms

<Active Sites><Affinity><Allosteric Regulation><Autoregulation><Biochemical><Biogenesis><Biology><Biosensor><Brain Pathology><CRISPR interference><CRISPR-dCas9-mediated repression><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Cell Communication and Signaling><Cell Signaling><Cell model><Cellular model><Chemicals><Citric Acid Cycle><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats interference><Colorectal Cancer><DNA mutation><Data><Dehydrogenases><Diet><Disease><Disorder><Electron Transport><Electrons><Energy Expenditure><Energy Metabolism><Epithelium><Foundations><Fumarates><Funding Mechanisms><GI microbiota><Gastrointestinal microbiota><Genetic Change><Genetic Models><Genetic defect><Genetic mutation><Genotype><Health><Homeostasis><Hydrogen Sulfide><Hypoxia><Hypoxic><Intermediary Metabolism><Intracellular Communication and Signaling><Krebs Cycle><L reuteri><L. reuteri><Laboratories><Lactobacillus reuteri><Leigh Disease><Leigh Syndrome><Lipids><Membrane Potentials><Metabolic><Metabolic Processes><Metabolism><Methionine><Mice><Mice Mammals><Microscopic><Mitochondria><Modeling><Molecular><Monitor><Morphology><Murine><Mus><Mutation><Negative Beta Particle><Negatrons><O element><O2 element><Origin of Life><Oxidation-Reduction><Oxidoreductase><Oxidoreductase Gene><Oxygen><Oxygen Deficiency><Physiological Homeostasis><Physiology><Plastic Embedding><Poisoning><Quinone Compound><Quinones><RNA Seq><RNA sequencing><RNAseq><Reaction><Redox><Reductases><Respiration><Resting Potentials><S element><Signal Transduction><Signal Transduction Systems><Signaling><Subacute Necrotizing Encephalomyelitis><Subacute Necrotizing Encephalomyelopathy><Subacute Necrotizing Encephalopathy><Sulfides><Sulfur><TCA cycle><Techniques><Toxic effect><Toxicities><Transmembrane Potentials><Tricarboxylic Acid Cycle><Tumor Burden><Tumor Load><aerobic glycolysis><biological sensor><biological signal transduction><carboxylation><cofactor><complex IV><dietary><diets><electron transfer><enteric microbial community><enteric microbiota><enzyme pathway><flexibility><flexible><gastrointestinal microbial flora><genome mutation><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiota><gut microbiotic><gut microflora><innovate><innovation><innovative><intestinal epithelium><intestinal flora><intestinal microbes><intestinal microbiota><intestinal microflora><intestinal tract microflora><live cell image><live cell imaging><live cellular image><live cellular imaging><metabolism measurement><metabolomics><metabonomics><microbial><microbial composition><microbial host><mitochondrial><mitochondrial membrane><multiomics><multiple omics><oxidation><oxidation reduction reaction><panomics><poisoned><programs><repressing CRISPR-dCas9 system><respiratory mechanism><response><transcriptome sequencing><transcriptomic sequencing><vapor>
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Johnathan R. Whetstine

RESEARCH INST OF FOX CHASE CAN CTR, PHILADELPHIA, PA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$467,500
FY 2026

Project Title

Deciphering Networks Controlling DNA Amplification

Grant Number:

5R35GM144131-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY DNA amplification is associated with pathological states such as neurological disorders, cardiac disease and cancer. At least 50% of the amplifications in cancer are transient extrachromosomal DNA (ecDNA). The transient behavior contributes to copy number plasticity, results in heter...

Research Terms

<Amplifiers><Automobile Driving><Behavior><Cancer Genes><Cancer-Promoting Gene><Cancers><Cardiac Diseases><Cardiac Disorders><Cell Body><Cells><Characteristics><Chemicals><Chromatin><Coupled><DNA><DNA amplification><DNA mutation><Data><Deoxyribonucleic Acid><Diploid><Diploidy><Disease><Disorder><EC 2.1.1><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><Gene Amplification><Generations><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genome><Genomics><Goals><Heart Diseases><Heterogeneity><Histones><Human Genome><Individual><Knowledge><L-Lysine><Laboratories><Lysine><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Maps><Methyltransferase><Microscopy><Molecular><Mutation><NIGMS><National Institute of General Medical Sciences><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Non-Polyadenylated RNA><Nuclear><Oncogenes><Pathologic><Pathway interactions><Population><Process><RNA><RNA Gene Products><Ribonucleic Acid><Role><Site><Transforming Genes><cancer cell><copy number alteration><driving><epigenetically><epigenome><extrachromosomal DNA><genome mutation><heart disorder><human whole genome><insight><long read seq><long-read sequencing><long-read transcript sequencing><malignancy><methylase><natural gene amplification><neoplasm/cancer><neurological disease><new drug target><new druggable target><new marker><new pharmacotherapy target><new therapeutic target><new therapy target><novel biomarker><novel drug target><novel druggable target><novel marker><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><prevent><preventing><response to therapy><response to treatment><social role><therapeutic response><therapeutic target><therapy response><tool><transmethylase><treatment response><treatment responsiveness>
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Changjian (Jim) Feng

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Good lead · 52/100
Likely hiring
Solid budget
Active award
$419,375
FY 2026

Project Title

Defining Functional Dynamics of Multidomain Redox Enzymes

Grant Number:

5R35GM156443-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Multidomain proteins make up a large portion of the human proteome. Protein dynamics due to flexible linkers connecting relatively rigid domains enable diverse biological functions, including electron transfer. Protein electron transfer lies at the heart of life. Traditional biophysi...

Research Terms

<Architecture><Area><Binding Proteins><Biological Function><Biological Process><Biology><Cell Communication and Signaling><Cell Signaling><Collection><Complex><Cues><Disease><Disorder><Docking><EDRF Synthase><Electron Transport><Endothelium-Derived Growth Factor Synthase><Engineering / Architecture><Enzyme Gene><Enzymes><Family><Guanylyl Cyclase-Activating Factor Synthase><Heterogeneity><Human><Individual><Intracellular Communication and Signaling><Investigation><Investigators><Isoforms><Life><Ligand Binding Protein><Ligand Binding Protein Gene><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Medicine><Methodology><Modern Man><Modification><Molecular><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Motion><NO Synthase><Nitric Oxide Synthase><Nitric-Oxide Synthetase><Oxidation-Reduction><Peptide Domain><Phosphorylation><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Postdoc><Postdoctoral Fellow><Posttranslational Modifications><Posttranslational Protein Processing><Process><Protein Binding><Protein Domains><Protein Dynamics><Protein Isoforms><Protein Modification><Protein Phosphorylation><Proteins><Proteome><Redox><Regulation><Research><Research Associate><Research Personnel><Researchers><Role><Science><Signal Transduction><Signal Transduction Systems><Signaling><Site><System><Techniques><Tertiary Protein Structure><Training><biological signal transduction><biophysical approaches><biophysical methodology><biophysical methods><biophysical techniques><bound protein><conformation><conformational><conformational state><conformationally><conformations><crosslink><electron transfer><flexibility><flexible><insight><method development><multidisciplinary><oxidation reduction reaction><post-doc><post-doctoral><post-doctoral trainee><programs><research associates><response><social role><spectroscopic study><spectroscopic survey><therapeutic agent development><therapeutic development><therapeutic target><undergrad><undergraduate><undergraduate student>
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Ken Solt

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$412,346
FY 2026

Project Title

Anesthesia and Consciousness

Grant Number:

5R35GM152187-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT General anesthetics are essential in medicine, providing unconsciousness, amnesia and analgesia for otherwise intolerable surgical procedures. Although general anesthetics are widely used, little is known about how the brain recovers consciousness after general anesthesia. ...

Research Terms

<Absence of pain sensation><Absence of sensibility to pain><Acceleration><Amnesia><Amnesia-Memory Loss><Anesthesia><Anesthesia procedures><Anesthestic Drugs><Anesthetic Agents><Anesthetic Drugs><Anesthetics><Arousal><Attention><Brain><Brain Nervous System><Cell Nucleus><Clinical><Cognition><Cognitive><Common Rat Strains><Conscious><Consciousness><Delirium><Differences between sexes><Differs between sexes><Encephalon><Estrous Cycle><Feels no pain><Female><General Anesthesia><General Anesthetics><General anesthetic drugs><Goals><Grant><Knowledge><Medicine><Memory><No sensitivity to pain><Nucleus><Operative Procedures><Operative Surgical Procedures><Rat><Rats Mammals><Rattus><Recovery><Research><Rodent><Rodentia><Rodents Mammals><Sex Differences><Sexual differences><Surgical><Surgical Interventions><Surgical Procedure><Testing><Unconscious><Unconscious State><Unconsciousness><analgesia><cognitive assessment><cognitive recovery><cognitive testing><common treatment><consciousness loss><delirious><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><insight><neural circuit><neural circuitry><neurocircuitry><new approaches><novel approaches><novel strategies><novel strategy><programs><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><surgery><synaptic circuit><synaptic circuitry><touch panel><touch screen><touch screen panel><touchscreen><touchscreen panel><♀>
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James E. Casanova

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$403,750
FY 2026

Project Title

ARFs, ORPs and the control of cell migration

Grant Number:

5R35GM152130-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

The ADP-ribosylation factors (ARFs) are a family of six small, Ras-like GTPases best known for their roles in membrane trafficking, where they control the formation of carrier vesicles at multiple intracellular sites. Over the years, we have defined roles for ARFs and their regulators (GEF and GAPs)...

Research Terms

<ADP-Ribosylation Factors><AMPA Receptors><ARF Protein Cofactor><Actins><Adhesion Plaques><Adhesions><Attention><Automobile Driving><Calcium><Calcium Channel><Calcium Channel Antagonist Receptor><Calcium Channel Blocker Receptors><Calcium Ion Channels><Calcium Ion Signaling><Calcium Signaling><Cell Body><Cell Function><Cell Locomotion><Cell Migration><Cell Movement><Cell Physiology><Cell Process><Cell membrane><Cell-Matrix Adherens Junctions><Cells><Cellular Function><Cellular Matrix><Cellular Migration><Cellular Motility><Cellular Physiology><Cellular Process><Choline Glycerophospholipids><Choline Phosphoglycerides><Complex><Cytoplasmic Membrane><Cytoskeletal System><Cytoskeleton><DNA mutation><Data><Embryo Development><Embryogenesis><Embryonic Development><Endocytosis><Endoplasmic Reticulum><Ergastoplasm><Failure><Family><Focal Adhesions><Focal Contacts><GTP Phosphohydrolases><GTPases><Genetic Change><Genetic defect><Genetic mutation><Glia><Glial Cells><Goals><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Human><Inflammation><Inositide Phospholipids><Inositol Phosphoglycerides><Inositol Phospholipids><Integrins><Integrins Extracellular Matrix><Isoforms><Kolliker's reticulum><Lecithin><Lipids><Membrane><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Micro-tubule><Microtubules><Modern Man><Molecular><Mutation><Neoplasm Metastasis><Neuroglia><Neuroglial Cells><Non-neuronal cell><Nonneuronal cell><Patients><Phosphatidyl Inositol><Phosphatidylcholines><Phosphatidylinositols><Phosphoinositides><Physiologic><Physiological><Plasma Membrane><Process><Protein Isoforms><Proteins><PtdIns><Publishing><Reporting><Role><Secondary Neoplasm><Secondary Tumor><Site><Subcellular Process><VDCC><Vesicle><Voltage-Dependent Calcium Channels><Wound Repair><X-Linked Mental Retardation><X-Linked Mental Retardation Disorders><X-Linked Mental Retardation Syndromes><X-linked intellectual disability><cancer metastasis><cell motility><driving><excitatory neuron><genome mutation><guanosinetriphosphatase><intracellular skeleton><lipid exchange protein><lipid transfer protein><member><membrane structure><migration><nerve cement><novel><plasmalemma><postsynaptic><protein function><response><rho><social role><trafficking><tumor><tumor cell metastasis><wound healing><wound recovery><wound resolution>
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Fumika Hamada

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$402,500
FY 2026

Project Title

Molecular and Neural Mechanisms of Temperature Preference Rhythm in Drosophila

Grant Number:

5R35GM152154-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY: Circadian rhythm is important for human physiology and health. Human body temperature increases during wakefulness and decreases during sleep. This body temperature rhythm (BTR) is a robust output of the circadian clock and is fundamental for maintaining homeostasis and its related processe...

Research Terms

<Autoregulation><Body Temperature><Calcitonin Receptor><Circadian Rhythms><Disease><Disorder><Drosophila><Drosophila genus><Environment><Exhibits><Flies><Foundations><GeneHomolog><Genes><Goals><Health><Homeostasis><Homolog><Homologous Gene><Homologue><Human><Human Figure><Human body><Intermediary Metabolism><Jet Lag><Jet Lag Syndrome><Jetlag><Jetlag Syndrome><Knowledge><Life><Link><Locomotor Activity><Mammalia><Mammals><Metabolic Processes><Metabolism><Modeling><Modern Man><Molecular><Motor Activity><Neuropeptide Receptor><Nyctohemeral Rhythm><Outcome><Output><Pace Stimulators><Pacemakers><Pathway interactions><Pattern><Physiological Homeostasis><Physiology><Process><Receptor Signaling><Research><Sleep><Sleep Disorders><Sleep disturbances><Temperature><Time><Time Zone Change Syndrome><Time Zone Syndrome><Twenty-Four Hour Rhythm><Wakefulness><aberrant sleep><circadian clock><circadian pacemaker><circadian process><circadian rhythmicity><daily biorhythm><day shift><disrupted sleep><disturbed sleep><fly><fruit fly><impaired sleep><innovate><innovation><innovative><insight><irregular sleep><neural circuit><neural circuitry><neural mechanism><neurocircuitry><neuromechanism><night shift><night work><pathway><preference><shift work><shiftwork><sleep control><sleep diseases><sleep disruption><sleep dysfunction><sleep dysregulation><sleep illness><sleep problem><sleep regulation><sleep/wake disruption><sleep/wake disturbance><sleep/wake regulation><synaptic circuit><synaptic circuitry>
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Minkyu Kim

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 52/100
Likely hiring
Solid budget
Active award
$393,750
FY 2026

Project Title

Dissecting the DNA Damage Response with Functional Proteomics

Grant Number:

5R35GM156189-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/22/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY The DNA damage response (DDR) entails a tightly choreographed reorganization of protein complexes involved in DNA repair and damage checkpoints. Post-translational modifications (PTMs) fulfil a crucial role in the DDR. However, the mechanisms by which these changes in proteome are dynamicall...

Research Terms

<53BP1><BARD-1><BARD1><BARD1 gene><BRCA1><BRCA1 Associated RING Domain 1 Protein><BRCA1 Gene Product><BRCA1 Protein><BRCA1 gene><BRCA1-Associated RING Domain 1><Biochemical><Biological><Breast Cancer 1 Gene><Breast Cancer 1 Gene Product><Breast Cancer Type 1 Susceptibility Gene><Breast Cancer Type 1 Susceptibility Protein><Breast-Ovarian Cancer Protein><Cell Body><Cells><Chromatin><DNA Damage><DNA Damage Repair><DNA Double Strand Break><DNA Injury><DNA Repair><DNA damage check point><DNA damage check point response><DNA damage checkpoint><DNA damage checkpoint response><DNA dependent protein kinase catalytic subunit><DNA-PKcs><Data><Defect><Dephosphorylation><Early Onset Gene Breast Cancer 1><Early Onset Protein Breast Cancer 1><Ensure><Environment><Hereditary Breast Cancer 1><Histones><Kinases><Kinetics><Laboratories><Learning><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Mediator><Monitor><NHEJ><Non-Homologous End Joining><Non-homologous DNA End Joining><Nonhomologous DNA End Joining><Nonhomologous End Joining><Pathway interactions><Phosphatases><Phosphohydrolases><Phosphomonoesterases><Phosphoprotein Phosphatase><Phosphoprotein Phosphatase-2C><Phosphoprotein Phosphohydrolase><Phosphoric Monoester Hydrolases><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Process><Protein Dephosphorylation><Protein Dynamics><Protein Modification><Protein Phosphatase C><Protein Phosphatase Gene><Protein Phosphatase-1><Protein Phosphatase-2A><Protein Phosphorylation><Protein Subunits><Protein phosphatase><Proteins><Proteome><Proteomics><Publishing><RNF53><Research><Role><Science><Site><Systems Biology><TP53BP1><Transphosphorylases><Tumor Suppressor Proteins><Unscheduled DNA Synthesis><biologic><brca 1 gene><demethylation><genome integrity><genomic integrity><insight><mutant><neurabin II><novel><p202><p53-binding protein 1><p53BP1><pathway><programs><protein complex><protein protein interaction><recruit><repair><repaired><response><social role><spinophilin><tool><tumor suppressor>
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Brenton D Hoffman

DUKE UNIVERSITY, DURHAM, NC

Good lead · 52/100
Likely hiring
Solid budget
Active award
$387,662
FY 2026

Project Title

Force-sensitive Linker Proteins as Mediators of Cellular Mechanosensitivity

Grant Number:

5R35GM156302-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT: Virtually every fundamentally important cellular process, including cell migration, division, death, differentiation, and metabolism, has been found to be dependent on mechanical cues. Similarly, many disease states impacting human health, but lacking effective treatments, are at least par...

Research Terms

<ASCVD><Affect><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Biochemical><Biological Function><Biological Process><Biosensor><Body Tissues><Cancers><Cell Body><Cell Function><Cell Locomotion><Cell Migration><Cell Movement><Cell Physiology><Cell Process><Cell-Extracellular Matrix><Cells><Cellular Function><Cellular Migration><Cellular Motility><Cellular Physiology><Cellular Process><Cellular biology><Cessation of life><Death><Development><Diagnosis><Disease><Disorder><ECM><Extracellular Matrix><Foundations><Goals><Health><Human><Intermediary Metabolism><Knowledge><Malignant Neoplasms><Malignant Tumor><Mechanics><Mediator><Metabolic Processes><Metabolism><Modern Man><Molecular><Phosphorylation><Physiologic><Physiological><Prevention><Process><Protein Engineering><Protein Phosphorylation><Proteins><Role><Specificity><Subcellular Process><Techniques><Technology><Tissues><Translating><Transmission><Work><assessment app><assessment application><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><biological sensor><cell behavior><cell biology><cell motility><cellular behavior><developmental><effective therapy><effective treatment><flexibility><flexible><genetic protein engineering><hemodynamics><malignancy><mechanic><mechanical><mechanical cue><mechanical load><mechanical signal><mechanical stimulus><molecular scale><neoplasm/cancer><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><protein design><protein function><social role><tool><transmission process><virtual>
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Benjamin Robert Morehouse

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$379,823
FY 2026

Project Title

Defining the mechanisms that drive novel cyclic nucleotide signaling in immune defense

Grant Number:

5R35GM157311-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary- R35 Application PI: Benjamin R. Morehouse Ph.D. The innate immune system is the critical first line of defense against microbial pathogens and is also a key player in the response to cellular stress. A thorough understanding of innate immune function and disfunction is necessary if ...

Research Terms

<Archaea><Archaebacteria><Archaeobacteria><Archaeon><Autoimmune Diseases><Back><Bacteria><Bacteriophages><Biochemical><Bioinformatics><Cancers><Cell Communication and Signaling><Cell Signaling><Cellular Expansion><Cellular Growth><Cellular Stress><Cellular Stress Response><Chemicals><Cyclic GMP><Cyclic Nucleotides><Cyclicity><Dinucleoside Phosphates><Distant><Doctor of Philosophy><Dorsum><Elements><Enzyme Gene><Enzymes><Face><GeneHomolog><Guanosine Cyclic Monophosphate><Health Care><History><Homolog><Homologous Gene><Homologue><Human><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune system><Immunes><Immunity><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Infection><Infectious Agent><Innate Immune System><Innate Immunity><Intracellular Communication and Signaling><Intracellular Second Messenger><Life><Link><Malignant Neoplasms><Malignant Tumor><Mediating><Modern Man><Modernization><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Nucleotides><Oligo><Oligonucleotides><Organism><Outcome><Pathway interactions><Periodicity><Ph.D.><PhD><Phages><Phylogenetic Analysis><Phylogenetics><Planets><Production><Prokaryotae><Prokaryotic Cells><Pyrimidine><Recording of previous events><Research><Resistance><Rhythmicity><Second Messenger Systems><Second Messengers><Shapes><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Societies><Stimulator of Interferon Genes><System><Testing><Viral><Viral Diseases><Virus Activation><Virus Diseases><Virus Induction><anti-microbial resistant pathogen><antimicrobial resistant pathogen><autoimmune condition><autoimmune disorder><autoimmunity disease><bacterial virus><biological signal transduction><cGAMP STING><cGAMP-STING><cGAMP/STING><cGAS/STING><cGMP><cell growth><cell stress><cyclic GMP-AMP synthase/STING><dinucleotide><faces><facial><fighting><histories><infectious organism><innate immune function><insight><interest><living system><malignancy><microbe pathogen><microbial pathogen><neoplasm/cancer><novel><nucleotide receptor><oligos><pathogen><pathogenic microbe><pathway><pharmacologic><prokaryote><resistant><response><signal transduction second messengers><structural biology><tumor><viral activation><viral induction><viral infection><virus infection><virus-induced disease>
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Bjorn C Knollmann

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Good lead · 50/100
Likely hiring
Large award
$1,020,000
FY 2025

Project Title

Toward a Mechanism-Based Approach to Treating Cardiac Arrhythmia

Grant Number:

5R35HL144980-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/6/2019

End Date:

2/28/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Sudden cardiac death due to ventricular arrhythmias is a major public health problem, accounting for 10-20% of all deaths in adults in the US. Current predictors can identify patient subsets at high risk, but unfortunately sudden death is the first manifestation of heart disease in up to half the vi...

Research Terms

<21+ years old><Academia><Accounting><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Anti-Arrhythmia Agents><Anti-Arrhythmia Drugs><Anti-Arrhythmics><Area><Arrhythmia><Cardiac Arrhythmia><Cardiac Diseases><Cardiac Disorders><Catecholaminergic Polymorphic Ventricular Tachycardia><Cessation of life><Clinical><Death><Development><Disease><Disorder><Drug Industry><Drug Therapy><Dysfunction><Functional disorder><Goals><Heart><Heart Arrhythmias><Heart Diseases><Hereditary><Human><Implantable Cardioverter-Defibrillators><Implantable Defibrillators><Inherited><Ion Channel><Ionic Channels><Knowledge><Membrane><Membrane Channels><Modern Man><Molecular><Patient Care><Patient Care Delivery><Patients><Pharmaceutic Industry><Pharmaceutical Industry><Pharmacological Treatment><Pharmacotherapy><Physiopathology><Precision care><Public Health><Research><Sight><Sudden Death><Syndrome><Therapeutic><Ventricular Arrhythmia><Vision><Work><adulthood><arrhythmic agent><care for patients><care of patients><caring for patients><cost><developmental><drug development><drug intervention><drug treatment><heart cell><heart disorder><hiPSC><high risk><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><improved><individualized care><individualized patient care><induced human pluripotent stem cells><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><membrane structure><model of animal><mortality><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><pathophysiology><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><patient-derived pluripotent stem cells><personalized care><personalized patient care><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><premature><prematurity><programs><sudden cardiac death><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><visual function>
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Christopher Warren Seymour

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$473,447
FY 2025

Project Title

Sepsis online: learning while doing to understand biology and treatment

Grant Number:

5R35GM119519-10

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/2/2016

End Date:

5/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY / ABSTRACT More than 1 million Americans are hospitalized with sepsis each year, and nearly one in five don’t survive. Most efforts to reduce sepsis deaths begin with the premise that patients are largely similar, and that ether moving treatment earlier or targeting therapeutics to a...

Research Terms

<AI system><American><Artificial Intelligence><Award><Biological><Biological Markers><Biology><Blood><Blood Reticuloendothelial System><Collection><Computational Biology><Computer Reasoning><E-learning><Early treatment><Electronic Health Record><Ethers><Funding><Hospital Admission><Hospitalization><Immunology><Inflammation><Integrated Health Care Systems><Laboratories><Learning><Machine Intelligence><Machine Learning><Mentorship><Methods><Molecular><NIGMS><National Institute of General Medical Sciences><Outcome><Patients><Policies><Precision care><Psychological reinforcement><Reinforcement><Science><Scientist><Sepsis><Systems Biology><Testing><Time><Uncertainty><Work><antisepsis treatment><bio-markers><biologic><biologic marker><biomarker><clinical decision-making><clinical translation><clinically translatable><computer biology><computer-assisted instruction><computer-based education><computer-based instruction><computer-based learning><computer-based training><death due to sepsis><death related to sepsis><digital education><digital learning><doubt><eLearning><early therapy><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic learning><electronic medical health record><health IT><health information technology><improved><improved outcome><individualized care><individualized patient care><insight><integrated health system><integrated system of care><internet-assisted education><internet-based training><machine based learning><machine learning based method><machine learning method><machine learning methodologies><microbiome><mortality associated with sepsis><mortality in sepsis><multimedia learning><on-line education><on-line learning><online education><online learning><pathogen><personalized care><personalized patient care><point of care><pressure><programs><response to therapy><response to treatment><sepsis associated death><sepsis associated mortality><sepsis care><sepsis caused deaths><sepsis death><sepsis induced death><sepsis induced mortality><sepsis interventions><sepsis lethality><sepsis management><sepsis mortality><sepsis related deaths><sepsis related mortality><sepsis therapeutics><sepsis therapy><sepsis treatment><septic death><septic mortality><septic therapy><septic treatment><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><technology-enhanced learning><therapeutic response><therapy optimization><therapy response><treat sepsis><treatment optimization><treatment response><treatment responsiveness><virtual learning><web-based instruction><web-based training>
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XIAOQIN ZOU

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Good lead · 46/100
Likely hiring
Solid budget
Active award
$470,606
FY 2025

Project Title

Integrative approaches for predicting protein interactions and applications

Grant Number:

2R35GM136409-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

6/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

The ability to accurately predict protein interactions is critical for the mechanistic investigation of many biological processes and for rational therapeutic development. Over the past decades, methods ranging from physicochemical-based approaches to template-based and machine learning-based approa...

Research Terms

<Address><Antibodies><Antigens><Bioinformatics><Biological Function><Biological Process><Charge><Classification><Collaborations><Communication><Complex><Computational toolkit><Computer software><Computing Methodologies><Copyright><Country><Development><Diabetic wound><Disease><Disorder><Docking><Funding><Funding Mechanisms><Goals><Grant><International><Investigation><Journals><Lead><Legal patent><Ligands><Machine Learning><Magazine><Manuscripts><Methods><Nature><Network-based><Paper><Patents><Pb element><Peer Review><Peptides><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Physics><Point Mutation><Proteins><Publishing><Research><Software><Source Code><Structure><Systematics><Technology><Therapeutic><Universities><blind><computational methodology><computational methods><computational toolbox><computational tools><computational toolset><computer based method><computer methods><computerized tools><computing method><deep learning algorithm><deep learning based neural network><deep learning neural network><deep neural net><deep neural network><design><designing><developmental><diabetes ulcer><diabetic skin wound><diabetic ulcer><diabetic wound healing><flexibility><flexible><graph attention network><graph convolutional network><graph neural network><heavy metal Pb><heavy metal lead><immunogen><in silico><machine based learning><novel><pharmaceutical><protein complex><protein protein interaction><screening><screenings><simulation><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic development><tool><web server>
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Michael J Bollong

SCRIPPS RESEARCH INSTITUTE, THE, LA JOLLA, CA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$460,000
FY 2025

Project Title

Methods and approaches to expand the pharmacological toolset

Grant Number:

5R35GM146865-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2022

End Date:

6/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project summary Our laboratory identifies small molecules with physiological activity to advance biological discovery and to develop new medicines. The principal goal of this R35 early-stage investigator MIRA proposal will be to enable our research effort collectively, which we believe will be best ...

Research Terms

<Animal Model><Animal Models and Related Studies><Area><Biological><Body Tissues><Carbon><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Stress><Cellular Stress Response><Chemicals><Clinical><Enzyme Gene><Enzymes><Family><Gene Transcription><Genetic Transcription><Goals><Heat Shock><Heat-Shock Reaction><Heat-Shock Response><Intermediary Metabolism><Intracellular Communication and Signaling><Investigators><Knowledge><Laboratories><Language><Libraries><Ligands><Logic><Medicine><Metabolic Processes><Metabolism><Methodology><Methods><Modernization><Organ healing><Oxidative Stress><Pathway interactions><Physiologic><Physiological><Property><RNA Expression><Regenerative Medicine><Research><Research Personnel><Researchers><Signal Transduction><Signal Transduction Systems><Signaling><Techniques><Therapeutic><Tissues><Transcription><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcriptional Activator/Coactivator><Work><biologic><biological adaptation to stress><biological signal transduction><cell stress><chemical library><drug development><model of animal><novel><organ repair><pathway><pharmacologic><progenitor cell pool><progenitor cell population><progenitor pool><progenitor population><protein homeostasis><proteostasis><reactioncrisis><regenerative><regenerative tissue><response><screening><screenings><small molecule><small molecule libraries><stem and progenitor cell population><stem cell pool><stem cell population><stress response><stressreaction><tissue repair><tool>
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Yunfeng Chen

UNIVERSITY OF TEXAS MED BR GALVESTON, GALVESTON, TX

Good lead · 46/100
Likely hiring
Solid budget
Active award
$440,000
FY 2025

Project Title

Deciphering Mechanosignaling Using Multi-fluorescence Biomembrane Force Probe

Grant Number:

1R35GM159909-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

5/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract This R35 proposal represents a comprehensive program that dives into the understanding of mechanosignaling, while providing training and mentorship to young scientists. The principal investigator (PI) has over a decade of experience in molecular and cellular mechanobiology i...

Research Terms

<Basic Research><Basic Science><Biomechanics><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Communication><Diagnostic><Disease><Disorder><Family><Fluorescence><Future><Genetics-Mutagenesis><Grant><Home><In Vitro><Integrins><Integrins Extracellular Matrix><Intracellular Communication and Signaling><Life><Ligand Binding><Mechanoreceptor Cell><Mediating><Mentorship><Methodology><Methods><Molecular><Molecular Configuration><Molecular Conformation><Molecular Dynamics Simulation><Molecular Modeling Nucleic Acid Biochemistry><Molecular Modeling Protein/Amino Acid Biochemistry><Molecular Models><Molecular Stereochemistry><Mutagenesis><Mutagenesis Molecular Biology><Pathogenesis><Pathology><Physiology><Play><Principal Investigator><Receptor Protein><Research><Role><Scientist><Secure><Seminal><Signal Transduction><Signal Transduction Systems><Signaling><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Structure><Study models><System><Technology><Therapeutic><Tissues><Training><Translating><Translational Research><Translational Science><Transmission><Work><biological signal transduction><biomechanical><biophysical model><cell engineering><cellular engineering><conformation><conformational><conformational state><conformationally><conformations><disease diagnosis><experience><homes><improved><in silico><insight><molecular dynamics><molecular modeling><new approaches><novel approaches><novel strategies><novel strategy><programs><receptor><social role><success><superresolution imaging><translation research><translational investigation><transmission process>
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Faraaz Ali Shah

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$437,250
FY 2025

Project Title

Improving Characterization of Individualized Treatment Effects in Critical Illness

Grant Number:

1R35GM160146-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT ABSTRACT Sepsis and acute respiratory distress syndrome (ARDS) are common and potentially fatal critical care disorders in need of improved therapeutic approaches. Developing effective treatment strategies for sepsis and for ARDS has been challenging in part due to disease heterogeneity with...

Research Terms

<ARDS><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Adult ARDS><Adult RDS><Adult Respiratory Distress Syndrome><Aeroseb-HC><Award><Biological><Biological Markers><Biological Specimen Banks><Biological Substance Banks><Cell Communication and Signaling><Cell Signaling><Cetacort><Characteristics><Clinical><Clinical Treatment><Computer Models><Computerized Models><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Critical Care><Critical Illness><Critically Ill><Da Nang Lung><Data Set><Dermacort><Disease><Disorder><Eldecort><Endocrine><Enteral Nutrition><Funding><Glucocorticoids><Heterogeneity><Hospitals><Hydrocortisone><Hydrocortone><Hytone><Immune response><Individual><Intensive Care Units><Intervention><Intracellular Communication and Signaling><Investigation><Machine Learning><Measures><Methodology><Methods><Modeling><Multiomic Data><Nutracort><Outcome><Patients><Pattern><Phenotype><Placebos><Proctocort><Research><Resuscitation><Sepsis><Sepsis and ARDS><Septic Shock><Severity of illness><Sham Treatment><Shock Lung><Signal Transduction><Signal Transduction Systems><Signaling><Stiff lung><Subgroup><Testing><Therapeutic><Work><acute respiratory distress syndrome caused by sepsis><antisepsis treatment><bio-markers><biologic><biologic marker><biological signal transduction><biological specimen repository><biomarker><biosample repository><biospecimen bank><biospecimen repository><care as usual><clinical intervention><clinical therapy><co-morbid><co-morbidity><cohort><comorbidity><computational modeling><computational models><computer based models><computerized modeling><customized therapy><customized treatment><demographics><disease heterogeneity><disease severity><effective therapy><effective treatment><flexibility><flexible><host response><immune system response><immunoresponse><improved><individual patient><individualized medicine><individualized patient treatment><individualized predictions><individualized therapeutic strategy><individualized therapy><individualized treatment><insight><machine based learning><multiple omic data><patient specific therapies><patient specific treatment><personalized predictions><precision medicine><precision-based medicine><randomized, clinical trials><response><response to therapy><response to treatment><sepsis ARDS><sepsis acute respiratory distress syndrome><sepsis and acute respiratory distress syndrome><sepsis associated acute respiratory distress syndrome><sepsis care><sepsis induced ARDS><sepsis induced acute respiratory distress syndrome><sepsis interventions><sepsis management><sepsis related acute respiratory distress syndrome><sepsis therapeutics><sepsis therapy><sepsis treatment><septic therapy><septic treatment><sham therapy><specimen bank><specimen repository><tailored medical treatment><tailored therapy><tailored treatment><therapeutic response><therapy response><tool><treat sepsis><treatment as usual><treatment effect><treatment response><treatment responsiveness><treatment strategy><trial regimen><trial treatment><unique treatment><usual care><wet lung>
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Laura Forsberg White

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$412,500
FY 2025

Project Title

Maximizing Investigators' Research Award (R35)

Grant Number:

5R35GM141821-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2021

End Date:

5/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY The “Tools for Transmission of Agents and Conditions (TRAC)” program will synergize statistical and mathematical modeling work in three areas of application: 1) Tuberculosis (TB) incidence and transmission; 2) monitoring substance use disorder (SUD) patterns; and 3) SARS CoV-2 transm...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><AIDS/HIV><Address><Area><Award><COVID-19 transmission><COVID-19 virus><COVID-19 virus transmission><COVID19 virus><Cessation of life><CoV-2><CoV2><Collaborations><Communicable Diseases><Communication><Data><Data Bases><Data Set><Databases><Death><Disease><Disorder><Emergent Technologies><Emerging Technologies><HIV/AIDS><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Hot Spot><Incidence><Infectious Diseases><Infectious Disorder><Infrastructure><Intervention Strategies><Investigators><Link><M tuberculosis infection><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Machine Learning><Math Models><Methodology><Methods><Modeling><Monitor><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Pattern><Position><Positioning Attribute><Probabilistic Models><Probability Models><Public Health><Public Health Practice><Reproducibility><Research><Research Personnel><Researchers><Risk><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 transmission><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Statistical Models><Substance Use Disorder><TB infection><Transmission><Treatment Efficacy><Tuberculosis><United States><Work><Wuhan coronavirus><analytical tool><communicable disease transmission><coronavirus disease 2019 transmission><coronavirus disease 2019 virus><coronavirus disease 2019 virus transmission><coronavirus disease-19 virus><data base><determine efficacy><disease transmission><disseminated TB><disseminated tuberculosis><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experience><hCoV19><improved><infection due to Mycobacterium tuberculosis><infectious disease transmission><innovate><innovation><innovative><intervention efficacy><machine based learning><mathematic model><mathematical model><mathematical modeling><mortality><nCoV2><pandemic><pandemic disease><programs><severe acute respiratory syndrome coronavirus 2 transmission><skills><statistical linear mixed models><statistical linear models><substance use and disorder><synergism><therapeutic efficacy><therapy efficacy><tool><transmission process><transmitted COVID-19><transmitted SARS-CoV-2><transmitted coronavirus disease 2019><transmitted severe acute respiratory syndrome coronavirus 2><tuberculosis infection><tuberculous spondyloarthropathy>
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Juan Manuel Schvartzman

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 46/100
Likely hiring
Solid budget
Active award
$411,250
FY 2025

Project Title

Effects of polyamines on chromatin function

Grant Number:

5R35GM154927-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2024

End Date:

5/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY The traditional view of cellular metabolism is that metabolic reactions exist to maximize catabolic (energy generation) or anabolic (growth) states. Over the past decade, we and others have begun to appreciate that metabolism also regulates chromatin function, as chemicals that modif...

Research Terms

<Abnormal Assessment of Metabolism><Abscission><Affect><Anabolism><Area><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Binding><Biological Function><Biological Process><Biology><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Nucleus><Cell Reprogramming><Cells><Cellular Expansion><Cellular Growth><Charge><Chemicals><Chromatin><DNA><DNA Replication><DNA Synthesis><DNA biosynthesis><Deoxyribonucleic Acid><Deposit><Deposition><Enzyme Antagonist><Enzyme Gene><Enzyme Inhibitor><Enzyme Inhibitor Agent><Enzyme Inhibitor Drugs><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Eukaryotic Cell><Excision><Extirpation><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Generations><Genetic Transcription><Growth><Histones><Homeostasis><In Vitro><Intermediary Metabolism><Metabolic><Metabolic Processes><Metabolic Studies><Metabolism><Metabolism Studies><Methods><Molecular Interaction><NIGMS><National Institute of General Medical Sciences><Non-Polyadenylated RNA><Nuclear><Nuclear Structure><Nucleus><Physiological Homeostasis><Polyamine Compound><Polyamines><Proliferating><Proteins><RNA><RNA Expression><RNA Gene Products><Reaction><Removal><Research><Ribonucleic Acid><Role><Stress><Surgical Removal><Tissue Growth><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Work><biosynthesis><cell growth><cellular differentiation><cellular reprogramming><chromatin modification><cofactor><epigenetically><extracellular><in vivo><infancy><infantile><macromolecule><metabolic abnormality assessment><ontogeny><progenitor><programs><resection><social role><tool><transcription factor>
View Full Project Details on NIH Reporter
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Jose Alfonso Rodriguez

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$409,283
FY 2025

Project Title

Micro Electron Diffraction of Toxic and/or Infectious Macromolecular Nanoassemblies

Grant Number:

5R35GM128867-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2018

End Date:

7/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY The field of structural biology is experiencing transformative change. New experimental and computational tools are revealing a remarkable catalogue of structures with unprecedented speed. In addition to the thousands of determined structures and the millions of new structure predictions, no...

Research Terms

<Acute><Amyloid><Amyloid Substance><Area><Award><Benign><Catalogs><Cell Components><Cell Structure><Cellular Structures><Chemicals><Complex><Computational toolkit><Development><Diagnostic><Disease><Disorder><Electron Microscopy><Event><Funding><Health><Higher Order Chromatin Folding><Higher Order Chromatin Structure><Higher Order Structure><Hybrids><In Situ><Life><Machine Learning><Macromolecular Structure><Methods><Micro Electron Diffraction><MicroEd><Molecular><Molecular Structure><Organism-Level Process><Organismal Process><Pathogenicity><Pathologic><Phase><Physiologic><Physiologic Processes><Physiological><Physiological Processes><Process><Protein Engineering><Proteins><Resolution><Role><Science><Speed><Structure><Therapeutic><Visualization><amyloid structure><catalog><computational toolbox><computational tools><computational toolset><computerized tools><developmental><experience><genetic protein engineering><improved><interest><machine based learning><macromolecule><nanoassembly><novel><protein complex><protein design><protein function><protein structure><protein structures><proteins structure><resolutions><single molecule><social role><stem><structural biology><tool><trait>
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Jessica Cardenas

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 46/100
Likely hiring
Solid budget
Active award
$390,000
FY 2025

Project Title

Endothelial regulation of inflammation in trauma and hemorrhagic shock

Grant Number:

5R35GM146859-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2022

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Complications that arise secondary to an exaggerated innate immune response, such as multiple organ failure, are a major cause of late-stage mortality in trauma patients. My overall goal is to initiate an innovative and translational research program focused on elucidating mechanisms through which t...

Research Terms

<Anabolism><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Area><Attenuated><Automobile Driving><Award><Binding><Biological><COVID-19><CV-19><Cell Communication and Signaling><Cell Signaling><Clinical><Coronavirus Infectious Disease 2019><Critical Illness><Critically Ill><Endothelial Cells><Endothelium><Funding><Goals><HSPG><Hemorrhagic Shock><Heparan Sulfate><Heparan Sulfate Proteoglycan><Heparitin Sulfate><Immune response><Immunomodulation><Inflammation><Inflammatory Response><Injury><Innate Immune Response><Intracellular Communication and Signaling><Investigation><Knowledge><MOF syndrome><Mediating><Mission><Modification><Molecular Interaction><Morbidity><Morbidity - disease rate><Multiple Organ Dysfunction Syndrome><Multiple Organ Failure><NIGMS><National Institute of General Medical Sciences><Organ><Organ failure><Pathogenesis><Proteoheparan Sulfate><QOL><Quality of life><Receptor Protein><Regulation><Research><Role><Secondary to><Sepsis><Signal Transduction><Signal Transduction Systems><Signaling><Sulfate><Surface><System><Therapeutic><Thrombase><Thrombin><Translational Research Enterprise><Transplantation><Trauma><Trauma patient><Traumatic injury><Variant><Variation><Vascular Endothelium><attenuate><attenuates><biologic><biological signal transduction><biosynthesis><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><driving><endothelial dysfunction><experiment><experimental research><experimental study><experiments><fibrinogenase><host response><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><improved><injuries><injury to organs><innovate><innovation><innovative><mortality><multiorgan failure><multiple organ system failure><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><organ injury><prevent><preventing><programs><receptor><social role><tool><translation research enterprise><translational research program><transplant><vascular contributions>
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Ying Samuel Hu

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 46/100
Likely hiring
Solid budget
Active award
$388,443
FY 2025

Project Title

Ultrasensitive quantification of cytokine release from T cells

Grant Number:

5R35GM146786-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2022

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Cytokines represent a broad range of small signaling proteins utilized by immune cells in cell-to-cell communications. Dysregulated cytokine release contributes to acute and long-term conditions, from life- threatening cytokine release syndrome to delayed wound healing. Targeting the...

Research Terms

<Acute><Antibodies><Architecture><Area><Assay><B220><Bioassay><Biologic Models><Biological Assay><Biological Models><CD45><Calcium Channel><Calcium Channel Antagonist Receptor><Calcium Channel Blocker Receptors><Calcium Ion Channels><Cell Body><Cell Communication><Cell Interaction><Cell Line><Cell membrane><Cell-to-Cell Interaction><CellLine><Cells><Cellular biology><Clinical Trials><Co-Stimulator><Complex><Costimulator><Cytoplasmic Membrane><Development><Disease><Disorder><Drug Targeting><ELISA><Engineering / Architecture><Enzyme-Linked Immunosorbent Assay><Epidermal Thymocyte Activating Factor><Event><FDA approved><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Future><GP180><Glass><Health><Human><IL-2><IL2 Protein><Image><Imaging Device><Imaging Instrument><Imaging Tool><Immune><Immunes><Impaired tissue repair><Impaired wound healing><Individual><Interleukin 2><Interleukin 2 Precursor><Interleukin II><Interleukin-2><Interleukine 2><Interleukine 2 Precursor><Interleukine II><Investigation><Ion Channel><Ionic Channels><Jurkat Cells><LY5><Life><Lymphocyte Mitogenic Factor><MHC Receptor><Major Histocompatibility Complex Receptor><Masks><Membrane><Membrane Channels><Mitogenic Factor><Model System><Modern Man><Molecular><PTPRC><PTPRC gene><Phenotype><Plasma Membrane><Process><Proteins><Receptor Signaling><Regulation><Research><Resolution><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Site><Strains Cell Lines><Systems Biology><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell growth factor><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cell Activation><T-Cell Antigen Receptors><T-Cell Growth Factor><T-Cell Proliferation><T-Cell Receptor><T-Cell Stimulating Factor><T-Cells><T-Lymphocyte><T-cell therapeutics><T-cell transfer therapy><T200><Techniques><Technology><Thymocyte Stimulating Factor><Time><Training><VDCC><Vesicle><Voltage-Dependent Calcium Channels><abnormal tissue repair><activate T cells><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><cell biology><clinical translation><clinically translatable><cultured cell line><cytokine><cytokine release syndrome><cytokine storm><delayed wound healing><developmental><enzyme linked immunoassay><extracellular vesicles><flow cytophotometry><imaging><immune imaging><immunoimaging><inhibitor><membrane structure><nano meter scale><nano meter sized><nanometer scale><nanometer sized><nanoscale><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><plasmalemma><programs><quantitative imaging><resolutions><response><screening><screenings><spatial and temporal><spatial temporal><spatiotemporal><superresolution microscopy><therapeutic T-cell platform><thymus derived lymphocyte><tool>
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Valerie Tutwiler

RUTGERS, THE STATE UNIV OF N.J., PISCATAWAY, NJ

Good lead · 46/100
Likely hiring
Solid budget
Active award
$387,370
FY 2025

Project Title

MIRA R35: Fibrin(ogen) in regulating health and disease

Grant Number:

5R35GM155242-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

5/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Fibrin(ogen) plays a critical role in processes such as wound healing, coagulation, cancer, pregnancy, and inflammation. Fibrin(ogen), which is a blood plasma protein, forms a hierarchical network that gives rise to its unique mechanical and enzymatic stability. There is a n...

Research Terms

<Address><Biochemical><Blood Plasma><Cancers><Clotting><Coagulation><Coagulation Process><Collagen><Diagnostic><Disease><Disorder><Drugs><Engineering><Fibrin><Gestation><Goals><Health><Inflammation><Kinetics><Laboratories><Malignant Neoplasms><Malignant Tumor><Mechanics><Medication><Pathologic><Pharmaceutical Preparations><Plasma><Plasma Proteins><Plasma Serum><Play><Pregnancy><Process><Property><Regulation><Resistance><Reticuloendothelial System, Serum, Plasma><Role><Rupture><Structure><Structure-Activity Relationship><Thrombosis><Work><Wound Repair><biophysical approaches><biophysical methodology><biophysical methods><biophysical techniques><chemical structure function><drug/agent><malignancy><mechanic><mechanical><mechanical properties><neoplasm/cancer><resistant><social role><structure function relationship><thrombotic disease><thrombotic disorder><viscoelasticity><wound healing><wound recovery><wound resolution>
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Jitendra Thakur

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$385,758
FY 2025

Project Title

R35 Investigating rapidly evolving centromeres and their role in the reproductive isolation in mammals

Grant Number:

5R35GM147558-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/19/2022

End Date:

6/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

RESEARCH SUMMARY Centromeric satellites and their binding partners are engaged in an ongoing evolutionary arms race such that each side is continuously evolving to win the race. As a result, centromeres are one of the most divergent genomic elements in populations, which ultimately stop exchanging g...

Research Terms

<Binding><Binding Proteins><Cancerous><Cancers><Cannot achieve a pregnancy><Cell Body><Cells><Cellular biology><Centromere><Chromosomal Disorders><Chromosome Abnormality Disorders><Chromosome Disorders><Chromosome Segregation><Complex><Congenital chromosomal disease><Difficulty conceiving><Elements><Evolution><Failure><Genetic><Genetic Materials><Genomics><Geography><House mice><Hybrids><Impairment><Infertility><Intermediary Metabolism><Ligand Binding Protein><Ligand Binding Protein Gene><Malignant Neoplasms><Malignant Tumor><Mammalia><Mammals><Measurable><Measures><Meiosis><Metabolic Processes><Metabolism><Molecular Interaction><Mus musculus><Nature><Population><Process><Protein Binding><Proteins><Race><Races><Research><Role><Side><System><Testing><Time><Variant><Variation><Work><arms race><bound protein><cell biology><chromosome division><fertility cessation><fertility loss><forging><infertile><insight><male><malignancy><meiotic><multidisciplinary><neoplasm/cancer><overexpress><overexpression><racial><racial background><racial origin><reproductive><social role><♂>
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Paulo Sebastian Caceres

WAYNE STATE UNIVERSITY, DETROIT, MI

Good lead · 46/100
Likely hiring
Solid budget
Active award
$385,000
FY 2025

Project Title

Mechanisms of polarized protein sorting in AP-1B-deficient epithelia

Grant Number:

5R35GM150570-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

6/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Epithelial cells carry out secretory and absorptive functions that require the polarized distribution of transporters, receptors and adhesion molecules at the apical and basolateral plasma membranes. Acquisition and maintenance of apical-basolateral polarity involves sorting of plas...

Research Terms

<Adaptor Protein><Adaptor Protein Gene><Adaptor Signaling Protein><Adaptor Signaling Protein Gene><Adhesion Molecule><Alimentary Canal><Apical><Architecture><Autoregulation><Body Tissues><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Body><Cell membrane><Cell surface><Cells><Clathrin Adaptors><Clathrin Assembly Proteins><Clathrin-Associated Adaptors><Clathrin-Associated Proteins><Cytoplasmic Membrane><Diagnosis><Digestive Tract><Disease><Disorder><Endosomes><Engineering / Architecture><Epithelial Cells><Epithelial Physiology><Epithelium><Foundations><Funding Mechanisms><Future><GI Tract><GP330 Antigen><Gastrointestinal Tract><Gastrointestinal tract structure><Glycoprotein 330><Goals><Heyman's Nephritis Antigen GP330><Heymann Nephritis Antigen GP330><Homeostasis><Individual><Kidney><Kidney Urinary System><Knowledge><LDL-Receptor Related Protein 2><LRP-2><LRP-2 Receptor><Liquid substance><Liver><Low-Density Lipoprotein Receptor-Related Protein-2><Maintenance><Mediating><Mediator><Megalin><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Mission><Modeling><Molecular><NIGMS><National Institute of General Medical Sciences><Nephritis Antigen GP 330><Nervous System><Neurologic Body System><Neurologic Organ System><Organ><Outer pigmented layer of retina><Pathology><Pathway interactions><Physiologic><Physiological><Physiological Homeostasis><Pigment cell layer of retina><Pigmented layer of retina><Plasma Membrane><Process><Protein Sortings><Proteins><Proteomics><Proximal Kidney Tubules><Receptor Protein><Receptosomes><Recycling><Renal Glycoprotein GP330><Research><Retinal Pigment Epithelium><Retinal pigment epithelial cells><Role><Skin><Sorting><Structure><Structure of retinal pigment epithelium><Surface><Surface Proteins><Testing><Time><Tissues><Training Programs><adapter protein><alimentary tract><cell adhesion protein><digestive canal><disease prevention><disorder prevention><flexibility><flexible><fluid><gp 330><hepatic body system><hepatic organ system><kidney epithelial cell><liquid><novel><pathway><plasmalemma><programs><receptor><renal><renal proximal tubule><social role><sorting nexins><synaptobrevin><trafficking><vesicle-associated membrane protein>
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Renuka Rajendra Nayak

NORTHERN CALIFORNIA INSTITUTE/RES/EDU, SAN FRANCISCO, CA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$383,250
FY 2025

Project Title

From here to eternity: gut microbial response to drug therapy and inflammation

Grant Number:

5R35GM151349-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

8/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT The genomic revolution has provided us with an “embarrassment of riches” with respect to our understanding of the composition of gut microbial communities in disease, but we are still far from understanding how microbial genes and pathways impact host health. While a wealth of studies show ...

Research Terms

<Biological Response Modifier Therapy><Biological Therapy><Bionomics><Clinical Immunology><Disease><Disorder><Drug Targeting><Drug Therapy><Drugs><Ecology><Evolution><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genes><Genetic><Genetic Determinism><Genomics><Goals><Grant><Health><Human><Inflammation><Inflammatory><Knowledge><Medication><Microbe><Microbial Genetics><Microbiology><Modern Man><NIGMS><National Institute of General Medical Sciences><Pathway interactions><Patients><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Productivity><Research><Resolution><Science of Microbial Genetics><Shapes><Technology><Treatment Efficacy><biological therapeutic><biological treatment><biologically based therapeutics><biotherapeutics><biotherapy><community microbes><computer science><design><designing><digestive tract microbiome><drug intervention><drug treatment><drug/agent><enteric microbial community><enteric microbiome><enteric microbiota><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbial flora><gastrointestinal microbiome><genetic determinant><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><improved><in vivo><inhibitor><intervention efficacy><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><microbe community><microbial><microbial community><microbiome><microorganism community><microorganism genetics><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><polymicrobial community><programs><rational design><resolutions><response><small molecule><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy>
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Brian Russo

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 46/100
Likely hiring
Solid budget
Active award
$382,602
FY 2025

Project Title

The Role of Intermediate Filaments in Inflammation

Grant Number:

5R35GM146923-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2022

End Date:

6/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract: Intermediate filaments are highly conserved eukaryotic cytoskeletal proteins present in nearly every cell in the body. Although initially thought to simply provide structural support to cells, intermediate filaments are now implicated in a variety of biological processes due to their numer...

Research Terms

<Bacterial Infections><Biological Function><Biological Process><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Body Tissues><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell model><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular model><Cytoskeletal Gene><Cytoskeletal Proteins><Funding><Human><Inflammation><Inflammatory><Intermediate Filaments><Investigation><Laboratories><Marrow Neutrophil><Modern Man><Molecular><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Post-Translational Modification Site><Posttranslational Modification Site><Process><Proteins><Regulation><Role><Scientist><Subcellular Process><Tissues><Training><Vimentin><bacteria infection><bacterial disease><experience><flexibility><flexible><improved><migration><monomer><neutrophil><programs><screening><screenings><social role><trafficking>
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DAVID H SHERMAN

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 46/100
Likely hiring
Solid budget
Active award
$381,095
FY 2025

Project Title

Discovery and Characterization of Natural Product Systems

Grant Number:

5R35GM118101-10

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2016

End Date:

5/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary. In this competing renewal of R35 GM118101, we propose to focus on investigating and developing biocatalytic systems that generate complex natural products with high potential as therapeutic agents. This program has been highly productive with 34 publications over the past four years...

Research Terms

<Achievement><Achievement Attainment><Ally><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Area><Bacteria><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Complex><Development><Diels Alder><Diels Alder reaction><Enzyme Gene><Enzymes><Gatekeeping><Hydroxylation><Indole Alkaloids><Macrolides><Metabolic Glycosylation><Methods><Miscellaneous Antibiotic><Molecular Machines><Natural Products><PKS enzyme><Pathway interactions><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Process><Productivity><Publications><Reaction><Reporting><Research><Resistance to antibiotics><Resistant to antibiotics><Scientific Publication><Structure><System><Testing><Therapeutic Agents><Type I Polyketide Synthase><Work><antibiotic drug resistance><antibiotic resistant><coping><developmental><flexibility><flexible><gatekeeper><glycosylation><human pathogen><microbial><naturally occurring product><new approaches><next generation><novel approaches><novel strategies><novel strategy><pathway><pharmaceutical><polyketide synthase><polyketides><programs>
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Timothy D. Heden

LSU PENNINGTON BIOMEDICAL RESEARCH CTR, BATON ROUGE, LA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$375,000
FY 2025

Project Title

Defining the mechanisms of the glycophagy shunt and its role in metabolism

Grant Number:

5R35GM154665-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

6/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Glucose metabolism is tightly regulated and has a central role in cell biology, while dysregulated glucose metabolism is a common occurrence in various metabolic diseases such as cancer, heart disease, diabetes, and brain disease. Most glucose that enters a cell is shuttled through glycogen prior to...

Research Terms

<Acid Maltase Deficiency Disease><Autophagocytosis><Brain Diseases><Brain Disorders><Cancers><Cardiac Diseases><Cardiac Disorders><Cell Body><Cells><Cellular Metabolic Process><Cellular biology><Cytosol><D-Glucose><Danon Disease><Dextrose><Diabetes Mellitus><Diagnosis><Disease><Disorder><Encephalon Diseases><Enzyme Gene><Enzymes><Freedom><Generalized Glycogenosis><Genetic Diseases><Glucose><Glycogen><Glycogen Debranching Enzyme><Glycogen Phosphorylase><Glycogen Storage Disease IIb><Glycogen Storage Disease Type IIb><Glycogen storage disease type II><Glycogenosis 2><Glycogenosis Type II><Goals><Grant><Grips><Health><Heart Diseases><Influentials><Intermediary Metabolism><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Knowledge><Liberty><Lysosomal Enzyme Disorders><Lysosomal Storage Diseases><Lysosomal alpha-1,4-Glucosidase Deficiency Disease><Lysosomes><Malignant Neoplasms><Malignant Tumor><Mediating><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolism><Mice><Mice Mammals><Murine><Mus><Pathway interactions><Phosphorylase ab><Pompe Disease><Process><Research><Role><Shunt><Shunt Device><Sight><Thesaurismosis><Translating><Vision><Work><X Linked Vacuolar Cardiomyopathy and Myopathy><acid maltase deficiency><alpha 1,4 glucosidase deficiency><autophagy><cell biology><cell metabolism><cellular metabaolism><diabetes><flexibility><flexible><genetic condition><genetic disorder><genetically engineered cells><genetically modified cells><glucose metabolism><glycogen metabolism><glycogenolysis><grasp><heart disorder><inborn lysosomal enzyme disorder><innovate><innovation><innovative><lysosomal disease><lysosomal disorder><lysosome storage diseases><malignancy><metabolism disorder><neoplasm/cancer><novel><pathway><shunts><social role><tool><visual function>
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Yu-ming Mindy Huang

WAYNE STATE UNIVERSITY, DETROIT, MI

Good lead · 46/100
Likely hiring
Solid budget
Active award
$369,500
FY 2025

Project Title

Innovative Multiscale Modeling Techniques for Membrane-Bound Proteins

Grant Number:

1R35GM160192-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Innovative Multiscale Modeling Techniques for Membrane-Bound Proteins SUMMARY Our laboratory develops computer models to investigate biomolecular diffusion and interactions with a particular emphasis on membrane-bound proteins and lipid metabolism. The study of diffusion using empirical techniques f...

Research Terms

<2019-nCoV S protein><2019-nCoV spike glycoprotein><2019-nCoV spike protein><Acceleration><Binding><Binding Proteins><COVID-19 S protein><COVID-19 spike><COVID-19 spike glycoprotein><COVID-19 spike protein><Cancers><Computational toolkit><Computer Models><Computerized Models><Computing Methodologies><Dedications><Development><Diabetes Mellitus><Diffusion><Disease><Disorder><Face><Foundations><Glycans><Kinetics><Laboratories><Ligand Binding Protein><Ligand Binding Protein Gene><Ligands><Lipids><Malignant Neoplasms><Malignant Tumor><Mediating><Membrane><Metabolic Glycosylation><Methodological Studies><Modeling><Molecular><Molecular Interaction><Polysaccharides><Process><Protein Binding><Proteins><Research><SARS-CoV-2 S><SARS-CoV-2 S protein><SARS-CoV-2 spike><SARS-CoV-2 spike glycoprotein><SARS-CoV-2 spike protein><Severe acute respiratory syndrome coronavirus 2 S protein><Severe acute respiratory syndrome coronavirus 2 spike glycoprotein><Severe acute respiratory syndrome coronavirus 2 spike protein><System><Techniques><Therapeutic><Validation><Viral><Virus><bound protein><computational methodology><computational methods><computational modeling><computational models><computational toolbox><computational tools><computational toolset><computer based method><computer based models><computer methods><computerized modeling><computerized tools><computing method><coronavirus disease 2019 S protein><coronavirus disease 2019 spike glycoprotein><coronavirus disease 2019 spike protein><coronavirus vaccine><develop a vaccine><develop vaccines><development of a vaccine><developmental><diabetes><diffused><diffuses><diffusing><diffusions><drug discovery><faces><facial><fat metabolism><glycosylation><innovate><innovation><innovative><insight><lipid metabolism><malignancy><membrane structure><multi-scale computational modeling><multi-scale mathematical modeling><multi-scale modeling><multiscale computational modeling><multiscale mathematical modeling><multiscale modeling><neoplasm/cancer><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pandemic><pandemic disease><protein function><protein metabolism><refractory cancer><resistant cancer><simulation><spike proteins on SARS-CoV-2><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><vaccine against coronavirus><vaccine candidate against coronavirus><vaccine development><validations>
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Jun Ninomiya-Tsuji

NORTH CAROLINA STATE UNIVERSITY RALEIGH, RALEIGH, NC

Good lead · 46/100
Likely hiring
Solid budget
Active award
$367,305
FY 2025

Project Title

TAK1 signaling pathways

Grant Number:

5R35GM139601-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2021

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract Innate immune signaling pathways are activated in response to exposure to microorganisms, and generally are effective in preventing pathogen invasion through inducing inflammation and host cell death. However, its aberrant activation is known to be causally associated with many inflammator...

Research Terms

<Adenosine Cyclic Monophosphate-Dependent Protein Kinases><Biological><Body Tissues><Cancers><Cell Communication and Signaling><Cell Death><Cell Signaling><Complex><Cyclic AMP-Dependent Protein Kinases><Disease><Disorder><Exposure to><Extracellular Signal-Regulated Kinase Gene><Funding Mechanisms><GEM model><GEMM model><Genetically Engineered Mouse><Immune signaling><Immunity><Infection><Inflammation><Inflammatory><Inflammatory Response><Innate Immunity><Intracellular Communication and Signaling><Invaded><MAP Kinase Gene><MAP kinase kinase kinase 7><MAP3K7><MAP3K7 gene><MAPK><Malignant Neoplasms><Malignant Tumor><Mediating><Mitogen-Activated Protein Kinase Gene><Molecular><Native Immunity><Natural Immunity><Nerve Degeneration><Neuron Degeneration><Non-Specific Immunity><Nonspecific Immunity><Outcome><PKA><Pathway interactions><Protein Kinase A><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><TAK1><TAK1a><TAK1b><TAK1c><TAK1d><TGF-Beta Activated Kinase 1><TGF-beta-activated kinase 1><Tissues><Transcription Activation><Transcriptional Activation><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><biologic><biological signal transduction><cAMP-Dependent Protein Kinases><experience><fighting><genetically engineered mouse model><genetically engineered murine model><malignancy><microorganism><mitogen-activated protein kinase kinase kinase 7><mouse model><murine model><necrocytosis><neoplasm/cancer><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><new approaches><novel approaches><novel strategies><novel strategy><pathogen><pathway><pharmacologic><prevent><preventing><response><transforming growth factor-beta-activated kinase 1>
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Ira A Tabas

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 44/100
Likely hiring
Above-average budget
$971,319
FY 2025

Project Title

A Mechanistic and Translational Research Program Linking Impaired Resolution, Defective Efferocytosis, and Clonal Hematopoiesis to the Formation of Clinically Dangerous Atherosclerotic Plaques

Grant Number:

5R35HL145228-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/7/2019

End Date:

2/28/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

This R35 proposal represents a comprehensive, long-term program that explores new mechanisms and therapeutic concepts related to the formation of the unique types of atherosclerotic plaques that cause acute cardiovascular disease (CVD). The training and mentoring of young scientists is also a key pa...

Research Terms

<ASCVD><Acute><Aging><Amino Acids><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Apoptotic><Area><Arterial Fatty Streak><Atheroma><Atheromatous><Atheromatous degeneration><Atheromatous plaque><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Atherosclerotic cap><Blood Cells><Blood monocyte><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cas nuclease technology><Causality><Cell Body><Cells><Clinical><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Complement><Complement Proteins><Dangerousness><Data><Dysfunction><Etiology><Fibrous Cap><Functional disorder><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic study><Grant><Heart Vascular><Human><Human Engineering><Human Genetics><Impairment><Inflammation><Intermediary Metabolism><Interruption><Investigators><Journals><Knowledge><Lead><Leanness><Link><Macrophage><Magazine><Marrow monocyte><Mediating><Mediator><Mentors><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Minority><Modern Man><Murine><Mus><Mφ><NIH><National Institutes of Health><Nature><Necrosis><Necrotic><Pathway interactions><Pb element><Peripheral Blood Cell><Physiopathology><Pre-Clinical Model><Preclinical Models><Process><Publishing><Recombinant DNA Technology><Research><Research Personnel><Researchers><Resolution><Risk Factors><Safety><Scientist><Sight><Testing><Therapeutic><Thinness><Tissues><Training><Translational Research Enterprise><United States National Institutes of Health><Vision><Work><age associated><age correlated><age dependent><age linked><age related><age specific><aging associated><aging related><amino acid metabolism><aminoacid><atheromatosis><atherosclerosis plaque><atherosclerotic disease><atherosclerotic lesions><atherosclerotic plaque><atherosclerotic vascular disease><cardiovascular disorder><causation><circulatory system><clinical relevance><clinically relevant><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><complementation><design><designing><disease causation><flexibility><flexible><genetically engineered><heavy metal Pb><heavy metal lead><hematopoietic cell clones><hematopoietic stem cell clonality><iPS><iPSC><iPSCs><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><monocyte><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathophysiology><pathway><plaque cap><plaques in atherosclerosis><precision medicine><precision-based medicine><programs><resolutions><translation research enterprise><translational research program><visual function>
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Harold A Chapman

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 44/100
Likely hiring
Above-average budget
$966,372
FY 2025

Project Title

Program to promote lung regeneration and block fibrosis

Grant Number:

5R35HL150767-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2020

End Date:

2/14/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT The goal of this research program is to understand the interactions between lung epithelial and mesenchymal cells in sufficient detail to deliver new therapeutic interventions in pulmonary fibrosis, a process without disease modifying therapies. This program is anchored by a recently funded...

Research Terms

<Alveolar><Animal Model><Animal Models and Related Studies><Attenuated><Automobile Driving><Biopsy><Body Tissues><Bone-Derived Transforming Growth Factor><Cell Body><Cells><Clinic><Clinical Trials><Data><Diagnostic><Dimensions><Disease><Disorder><Dysfunction><EGCG><EGCG cpd><Environment><Epigallocatechin Gallate><Epithelium><Failure><Fibroblasts><Fibrosis><Functional disorder><Funding><Future><Goals><Green Tea Extract><Green Tea Polyphenols><Health><Human><Injury><LOXL2><LOXL2 gene><Lung><Lung Grafting><Lung Respiratory System><Lung Tissue Fibrosis><Lung Transplantation><Lung fibrogenesis><Lung tissue regeneration><Lysyl Oxidase-Like 2><Mesenchymal><Mice><Mice Mammals><Milk Growth Factor><Modern Man><Morbidity><Morbidity - disease rate><Murine><Mus><Natural regeneration><Organoids><Pathway interactions><Patients><Physiopathology><Platelet Transforming Growth Factor><Process><Progenitor Cells><Pulmonary Fibrosis><Pulmonary Graft><Pulmonary Transplant><Pulmonary Transplantation><Pulmonary fibrogenesis><Regeneration><Research><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Tea catechin><Testing><Time><Tissues><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Type II Cell><Type II Epithelial Receptor Cell><attenuate><attenuates><cytokine><driving><epigallocatechin-3-gallate><epithelial injury><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><epithelium regeneration><fibrogenesis><fibrosis in the lung><fibrotic lung disease><fibrotic pulmonary disease><improved><in vivo><inhibitor><injuries><lung fibrosis><lung regeneration><lung transplant><model of animal><molecular imaging><molecule imaging><mortality><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathophysiology><pathway><progenitor><programs><pulmonary regeneration><regenerate><regenerate epithelium><resilience><resilient><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><small molecule><stem><stem cells><tissue biomarkers>
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Hideho Okada

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 44/100
Likely hiring
Above-average budget
$783,609
FY 2025

Project Title

Preclinical development of breakthrough immunotherapy for brain tumors

Grant Number:

5R35NS105068-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2017

End Date:

11/30/2025

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

The ultimate success of immunotherapy for brain malignancies, such as malignant glioma, will require integration of in-depth understanding of immunology with solutions for the following long-standing challenges: 1) paucity and heterogeneous expression of glioma-specific antigens; 2) poor homing and ...

Research Terms

<Address><Adopted><Adult Glioma><Antigen Targeting><Antigen-Presenting Cells><Antigens><Area><Award><Body Tissues><Brain><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell-Mediated Lympholytic Cells><Cells><Chemotactic Cytokines><Childhood Glioma><Collaborations><Cytolytic T-Cell><Cytotoxic T Cell><Cytotoxic T-Lymphocytes><Data><Ectopic lymphoid organ><Ectopic lymphoid structure><Encephalon><Engineering><Environment><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioma><Goals><Homing><Homologous Chemotactic Cytokines><Immune><Immune mediated therapy><Immune response><Immunes><Immunologically Directed Therapy><Immunology><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunotherapeutic agent><Immunotherapy><Intercrines><Intracellular Communication and Signaling><Laboratories><MHC Receptor><Major Histocompatibility Complex Receptor><Malignant Glial Neoplasm><Malignant Glial Tumor><Malignant Glioma><Malignant Neoplasms><Malignant Neuroglial Neoplasm><Malignant Neuroglial Tumor><Malignant Tumor><Mediating><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Neuroglial Neoplasm><Neuroglial Tumor><Normal Cell><Oncolytic viruses><Patients><Pediatric Glioma><Pediatric high-grade glioma><Research><SIS cytokines><Signal Transduction><Signal Transduction Systems><Signaling><Site><System><T cells for CAR><T-Cell Antigen Receptors><T-Cell Receptor><Technology><Tertiary lymphoid structure><Tissues><Tumor Antigens><Tumor-Associated Antigen><accessory cell><biological signal transduction><cancer antigens><cancer microenvironment><chemoattractant cytokine><chemokine><chimeric antigen T cell receptor><chimeric antigen receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><flexibility><flexible><glial-derived tumor><high risk><host response><immune drugs><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapeutics><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunologic therapeutics><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><immunotherapeutics><immunotherapy agent><immunotherapy clinical trials><killer T cell><lymph organ><lymphatic organ><lymphoid organ><malignancy><neo-antigen><neo-epitopes><neoantigens><neoepitopes><neoplasm/cancer><neuroglia neoplasm><neuroglia tumor><new technology><notch><notch protein><notch receptors><novel><novel technologies><pre-clinical development><pre-clinical study><preclinical development><preclinical study><success><tertiary lymphoid organ><tumor><tumor microenvironment><tumor-specific antigen><tumors in the brain>
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Andrew S Weyrich

OKLAHOMA MEDICAL RESEARCH FOUNDATION, OKLAHOMA CITY, OK

Exploratory lead · 44/100
Likely hiring
Above-average budget
$712,236
FY 2025

Project Title

Translational Control of Megakaryocyte and Platelet Gene Expression in Disease

Grant Number:

5R35HL145237-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2019

End Date:

12/31/2025

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Overall Summary/Abstract This Outstanding Investigator Award R35 program addresses previously-unexplored mechanisms by which regulation of gene expression at the translational level controls the functions of megakaryocytes and platelets, in the setting of health and disease. Studies will employ basi...

Research Terms

<Address><Award><Biology><Blood><Blood Clotting><Blood Diseases><Blood Platelets><Blood Reticuloendothelial System><Blood coagulation><Blood megakaryocyte><CDC33 Gene Product><Cardiac Diseases><Cardiac Disorders><Cardiac infarction><Cell Body><Cells><Clinic><Disease><Disorder><EIF-4E><EIF4E><Eukaryotic Initiation Factor-4E><Eukaryotic Peptide Initiation Factor-4E><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Health><Heart><Heart Diseases><Hematologic Diseases><Hematological Disease><Hematological Disorder><Human><Investigators><Knowledge><Lead><Lung><Lung Diseases><Lung Respiratory System><Marrow platelet><Megakaryocytes><Megalokaryocyte><Mice><Mice Mammals><Modern Man><Murine><Mus><Myocardial Infarct><Myocardial Infarction><Pathway interactions><Patients><Pb element><Peptide Initiation Factor EIF-4E><Platelets><Pulmonary Diseases><Pulmonary Disorder><Research><Research Personnel><Researchers><Role><Sepsis><Testing><Thrombocytes><blood disorder><cardiac infarct><clinical investigation><coronary attack><coronary infarct><coronary infarction><disease of the lung><disorder of the lung><heart attack><heart disorder><heart infarct><heart infarction><heavy metal Pb><heavy metal lead><inhibitor><lung disorder><new diagnostics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation diagnostics><next generation therapeutics><novel diagnostics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><programs><response><social role>
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Dengke Ma

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 36/100
Likely hiring
Solid budget
$398,125
FY 2025

Project Title

Genetic pathway and cellular mechanism underlying organismic responses to hypoxia and hypothermia

Grant Number:

5R35GM139618-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2021

End Date:

12/31/2025

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract Proper temperature and oxygen levels enable essential life activities. Low temperature (hypothermia) and reduced level of oxygen (hypoxia) pervasively influence fundamental biochemical processes, cellular metabolism, organismic physiology and behaviors. Hypoxia and oxidative...

Research Terms

<Abnormal Cell><Address><Apoplexy><Autoregulation><Behavior><Biochemical Process><Biologic Models><Biological Models><Brain Hypoxia-Ischemia><Brain Vascular Accident><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><California><Cardiac infarction><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Protection><Cells><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Citellus><Cytoprotection><Dedications><Disease><Disorder><Disparate><Equilibrium><Genes><Genetic><Genetic Determinism><Genetic Screening><Goals><Heart Vascular><Homeostasis><Hypothermia><Hypoxia><Hypoxic><Intermediary Metabolism><Ischemia><Killifishes><Laboratories><Life><Metabolic><Metabolic Processes><Metabolic stress><Metabolism><Model System><Myocardial Infarct><Myocardial Infarction><NIGMS><National Institute of General Medical Sciences><Neural Stem Cell><Neurologic><Neurological><O element><O2 element><Organism><Outcome><Oxidative Stress><Oxygen><Oxygen Deficiency><Pathway interactions><Phenotype><Physiologic><Physiological><Physiological Adaptation><Physiological Homeostasis><Physiology><Productivity><Proteins><RNA interference screen><RNAi screen><RNAi-based screen><Research><Research Institute><Research Resources><Resources><Running><San Francisco><Self-Fertilizations><Spermophilus><Stress><Stroke><Suslik><Technology><Temperature><Therapeutic><Therapeutic procedure><Universities><Variant><Variation><balance><balance function><behavior phenotype><behavioral phenotyping><brain attack><cardiac infarct><cerebral vascular accident><cerebrovascular accident><circulatory system><cold temperature><coping><coronary attack><coronary infarct><coronary infarction><cytoprotective><experience><genetic analysis><genetic determinant><ground squirrel><heart attack><heart infarct><heart infarction><hypoxia/ischemia><injury to tissue><innovate><innovation><innovative><interdisciplinary approach><interest><living system><low temperature><multidisciplinary approach><mutant><natural hypothermia><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><novel><pathway><progenitor and neural stem cells><programs><resilience><resilient><response><stroked><strokes><tissue injury><tool>
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Sudeshna Roy

UNIVERSITY OF TENNESSEE HEALTH SCI CTR, MEMPHIS, TN

Exploratory lead · 36/100
Likely hiring
Active award
$231,000
FY 2025

Project Title

Expanding the small molecule toolbox through novel applications of fluorinated alkenes

Grant Number:

5R35GM150768-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

6/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

New Methods and Chemical Tools Against Multi Drug-resistant Bacterial Infections ABSTRACT The central theme of our lab revolves around small molecules. We contribute to developing new methods and strategies to access small molecules of biological and medicinal relevance and using them as tools to pr...

Research Terms

<Address><Alkenes><Anti-Bacterial Agents><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Area><Award><Bacterial Drug Resistance><Bacterial Infections><Biological><Cell Components><Cell Structure><Cell Wall><Cellular Structures><Chemicals><Collaborations><Disparate><Environment><Enzyme Gene><Enzymes><Evolution><Fostering><Future><Goals><Health Care Industry><Heterocyclic Compounds><International><Learning><Ligands><Medicine><Metabolic Protein Degradation><Methods><Miscellaneous Antibiotic><Multi-Drug Resistance><Multidrug Resistance><Multiple Drug Resistance><Multiple Drug Resistant><Nitrogen><Olefins><Postdoc><Postdoctoral Fellow><Property><Protein Turnover><Regulatory Protein Degradation><Research><Research Associate><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistance to antibiotics><Resistant to Multiple Drug><Resistant to antibiotics><Resistant to multi-drug><Resistant to multidrug><Science><Structure><United States><Universities><Work><anti-bacterial><anti-bacterial drug resistance><anti-bacterial drug resistant><anti-bacterial resistance><anti-bacterial resistant><antibiotic drug resistance><antibiotic resistant><bacteria infection><bacterial disease><bacterial disease treatment><bacterial infectious disease treatment><biologic><cost><fascinate><global health><graduate student><human disease><innovate><innovation><innovative><insight><multi-drug resistant><multidisciplinary><multidrug resistant><new chemical entity><novel><post-doc><post-doctoral><post-doctoral trainee><programs><protein degradation><rational design><research associates><resistance strain><resistance to anti-bacterial><resistant strain><resistant to anti-bacterial><screening><screenings><skills><small molecule><tool><undergrad><undergraduate><undergraduate student>
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Ghazaleh Ashrafi

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 36/100
Likely hiring
Active award
$106,752
FY 2025

Project Title

Cellular mechanisms of bioenergetic plasticity

Grant Number:

3R35GM147222-04S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2022

End Date:

6/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Cellular mechanisms of bioenergetic plasticity (from the Parent R35 submission) The long-term goal of our research program is to understand how cells fine-tune their metabolic programs to meet their ever-changing energetic needs. Many cell types in the body, from muscle fibers to neurons, have evolv...

Research Terms

<Bioenergetics><Biosensor><Cell Body><Cell Energetics><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Communities><Complex><Coupled><Diabetes Mellitus><Disease><Disorder><Endocytosis><Energy Expenditure><Energy Metabolism><Eukaryotic Cell><Expression Signature><Gene Expression Profile><Genomics><Glycolysis><Goals><Intermediary Metabolism><Laboratories><Leigh Disease><Leigh Syndrome><Metabolic><Metabolic Processes><Metabolic dysfunction><Metabolism><Mitochondria><Molecular><Muscle Disease><Muscle Disorders><Muscle Fibers><Muscular Diseases><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Myotubes><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Parents><Pathway interactions><Process><Production><Regulation><Research><Rhabdomyocyte><Skeletal Fiber><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Stress><Subacute Necrotizing Encephalomyelitis><Subacute Necrotizing Encephalomyelopathy><Subacute Necrotizing Encephalopathy><Subcellular Process><Synaptic Vesicles><Work><biological sensor><cell imaging><cell type><cellular imaging><diabetes><flexibility><flexible><gene expression pattern><gene expression signature><metabolic imaging><mitochondrial><muscular disorder><neuronal><new technology><novel><novel technologies><optic imaging><optical imaging><parent><pathway><programs><tool><transcriptional profile><transcriptional signature><transcriptomics>
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JOSEPH CICHON

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 36/100
Likely hiring
Active award
$82,086
FY 2025

Project Title

Cellular and circuit mechanisms of the therapeutic action of inhaled nitrous oxide in rodent models of chronic stress

Grant Number:

3R35GM151160-03S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2023

End Date:

5/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

This administrative supplement request is submitted in support of R35GM151160-01, a project focused on elucidating the cellular and circuit mechanisms by which inhaled nitrous oxide exerts rapid antidepressant effects in rodent models of chronic stress. The parent award received a highly favorable i...

Research Terms

<5-HT><5-Hydroxytryptamine><5HT><Administrative Supplement><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anatomic Sites><Anatomic structures><Anatomy><Anesthestic Drugs><Anesthetic Agents><Anesthetic Drugs><Anesthetics><Architecture><Chronic stress><Corpus Striatum><Corpus striatum structure><Cre driver><Engineering / Architecture><Enteramine><Funding><Genetic><Goals><Hallucinogenic Agents><Hallucinogenic Drugs><Hallucinogenic Substances><Hallucinogens><Hippophaine><Hypothalamic structure><Hypothalamus><Image><Inhalation><Inhaling><Laughing Gas><Maps><Mediating><Mice><Mice Mammals><Microscope><Moods><Murine><Mus><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nitrous Oxide><Nucleus Accumbens><Output><Prefrontal Cortex><Psychedelic Agents><Psychedelics><Psychotomimetic Agents><Pyramidal neuron><Receptor Protein><Research><Resolution><Rodent Model><Serotonin><Speed><Striate Body><Striatum><System><Thalamic structure><Thalamus><Therapeutic><Therapeutic Effect><UV laboratory microscope><Ultraviolet Microscopes><United States National Institutes of Health><Ventral Tegmental Area><Visualization><amygdaloid nuclear complex><anatomic imaging><anatomical imaging><anti-depressant agent><anti-depressant drugs><anti-depressant effect><anti-depressants><anti-depressive agents><antidepressant effect><awake><experiment><experimental research><experimental study><experiments><fluorescence microscope><fluorescence/UV microscope><fluorescent microscope><hippocampal pyramidal neuron><hypothalamic><imaging><imaging in vivo><in vivo imaging><innovate><innovation><innovative><laboratory fluorescence light microscope><neuronal><parent award><parent project><psychedelic drug><psychotomimetic drug><receptor><reconstruction><resolutions><striatal><thalamic><tissue fixing><tool><ventral tegmentum>
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Matthew S. Gentry

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 36/100
Likely hiring
Active award
$74,309
FY 2025

Project Title

Brain Glycogen-Metabolism,Mechanisms, and Therapeutic Potential

Grant Number:

3R35NS116824-06S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2020

End Date:

4/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Brain metabolism is a fundamental aspect of biology and human disease. The brain critically depends on glucose, consuming large quantities as the biochemical fuel for cognition, memory, and behavior. Fundamental aspects of brain metabolism have been extensively studied, but recent evidence regarding...

Research Terms

<12-20 years old><AD dementia><Abscission><Adolescence><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Ataxia><Ataxy><Autoregulation><Behavior><Biochemical><Biology><Body Tissues><Brain><Brain Nervous System><Carbohydrates><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cellular Function><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Cessation of life><Cognition><Complex><Comprehension><Consumption><Coordination Impairment><D-Glucan><D-Glucose><DNA mutation><Data><Death><Development><Dextrose><Diagnosis><Disease><Disease Progression><Disorder><Dyssynergia><Encephalon><Epilepsy, Progressive Myoclonic, Lafora><Event><Excision><Extirpation><Freedom><Funding><Genetic Change><Genetic defect><Genetic mutation><Glucose><Glycogen><Glycogen Storage Disease><Glycogenosis><Homeostasis><Intermediary Metabolism><Intracellular Communication and Signaling><Intractable Epilepsy><Knowledge><Lafora Body Disease><Lafora Disease><Lafora Type Progressive Myoclonic Epilepsy><Liberty><Memory><Metabolic><Metabolic Processes><Metabolism><Modality><Modeling><Molecular><Mutation><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nerve Degeneration><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Neuron Degeneration><Patients><Physiological Homeostasis><Play><Primary Senile Degenerative Dementia><Refractory epilepsy><Removal><Research><Role><Seminal><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Surgical Removal><Symptoms><Therapeutic><Tissues><Translating><Vegetative States><Work><adolescence (12-20)><autosome><biological signal transduction><biomarker development><brain metabolism><cell metabolism><cellular metabaolism><develop therapy><developmental><driving force><drug-resistant epilepsy><flexibility><flexible><genome mutation><glucose metabolism><glycogen metabolism><human disease><insight><intervention development><mouse model><murine model><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neurological disease><neuronal degeneration><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><polyglucosan><pre-clinical><preclinical><primary degenerative dementia><resection><senile dementia of the Alzheimer type><sex><social role><therapy development><tool><treatment development>
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BENJAMIN MONTEVERDE KLEAVELAND

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Exploratory lead · 36/100
Likely hiring
Active award
$60,567
FY 2025

Project Title

Destruction of noncoding RNAs - R35 Diversity Supplement

Grant Number:

3R35GM147463-03S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2022

End Date:

7/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY Precise and dynamic control of gene expression is a balancing act between production and destruction. Although noncoding RNAs are critical regulators of gene expression with important roles in development and disease, our understanding of their destruction is still in its infancy. One of the...

Research Terms

<0-11 years old><20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><Area><Binding><Binding Sites><Cancers><Cell Body><Cell Line><CellLine><Cells><Child><Child Youth><Children (0-21)><Code><Coding System><Combining Site><Complex><Dedications><Development><Disease><Disorder><E3 Ligase><E3 Ubiquitin Ligase><Engineering><Environment><Functional RNA><Gene Expression><Genes><Knowledge><Macropain><Macroxyproteinase><Malignant Neoplasms><Malignant Tumor><Mediating><MicroRNAs><Modeling><Molecular Biology Techniques><Molecular Interaction><Multicatalytic Proteinase><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Organism><Outcome><Pathway interactions><Postdoc><Postdoctoral Fellow><Process><Production><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteosome><RNA><RNA Gene Products><Reactive Site><Regulation><Regulator Genes><Research><Research Associate><Resistance><Ribonucleic Acid><Role><Site><Slice><Stimulus><Strains Cell Lines><Synaptic Vesicles><Transcriptional Regulatory Elements><Transgenic Mice><Ubiquitilation><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><Untranslated RNA><Viral><Work><cell type><circular RNA><cis acting element><closed circular RNA><cultured cell line><developmental><gene product><genetic trans acting element><genome scale><genome-wide><genomewide><improved><infancy><infantile><kids><living system><malignancy><miRNA><multicatalytic endopeptidase complex><neoplasm/cancer><neuronal><noncoding><pathway><post-doc><post-doctoral><post-doctoral trainee><posters><posttranscriptional><recruit><regulatory gene><research associates><resistant><response><social role><trans acting element><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase><vesicle release><vesicular release><youngster>
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Lu Bai

PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA

Exploratory lead · 36/100
Likely hiring
Active award
$57,794
FY 2025

Project Title

Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation

Grant Number:

3R35GM139654-05S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2021

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract of Parent Award: (R35 GM139654 “Mechanism of chromatin accessibility, 3D chromosome organization, and their functions in gene regulation”) Tightly controlled gene expression is essential for the fitness and development of all living organisms, with mis- regulation often leading to disease. ...

Research Terms

<3-D><3-Dimensional><3D><ATAC><ATAC sequencing><ATAC-seq><ATACseq><Address><Assay for Transposase-Accessible Chromatin using sequencing><Baker's Yeast><Basal Transcription Factor><Basal transcription factor genes><Base Pairing><Benchmarking><Best Practice Analysis><Binding><Biochemistry><Bioinformatics><Biological Chemistry><Biomedical Research><Brewer's Yeast><Budding Yeast><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chromatin><Chromosomal Organization><Chromosomal Structure><Chromosome Organization><Chromosome Structures><DNA><Data><Data Set><Deoxyribonucleic Acid><Detection><Development><Disease><Disorder><Doctor of Philosophy><Endomycetales><Enhancers><Eukaryotic Cell><Event><Future><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Modified><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Transcription><Genome><Goals><Health><Human><Intellectual Property><Intracellular Communication and Signaling><Investigation><Knowledge><LPTN><Legal patent><MNase-seq><Mammalian Cell><Maps><Measurement><Methods><Micrococcal Nuclease><Micrococcal nuclease digestion of chromatin followed by sequencing><Micrococcal nuclease-sequencing><Mnase-Sequencing><Modern Man><Molecular Interaction><Nucleosomes><Organism><Outcome><Patents><Performance><Ph.D.><PhD><Population><Position><Positioning Attribute><Procedures><Protocol><Protocols documentation><Publications><Publishing><RNA Expression><Regulatory Element><Research><Resolution><Rest><S cerevisiae><S. cerevisiae><SCM-1><SCM-1a><SCM1><SCYC1><Saccharomyces cerevisiae><Saccharomycetales><Sampling><Scientific Publication><Side><Signal Transduction><Signal Transduction Systems><Signaling><Sonication><Staphylococcal Nuclease><TNase><Techniques><Technology><Testing><Thermonuclease><Thermostable Nuclease><Tn5 transposase><Trademark><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><United States><XCL1><XCL1 gene><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><benchmark><biological signal transduction><career><cost effective><developmental><experiment><experimental research><experimental study><experiments><fitness><gene modification><genetically modified><genome scale><genome-wide><genomewide><improved><insight><living system><novel><parent award><parent project><promoter><promotor><resolutions><simulation><three dimensional><training opportunity><transcription factor><yeast genome>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Timothy D. Heden

LSU PENNINGTON BIOMEDICAL RESEARCH CTR, BATON ROUGE, LA

Exploratory lead · 36/100
Likely hiring
Active award
$32,135
FY 2025

Project Title

Defining the mechanisms of the glycophagy shunt and its role in metabolism Supplement

Grant Number:

3R35GM154665-02S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

6/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Glucose metabolism is tightly regulated and has a central role in cell biology, while dysregulated glucose metabolism is a common occurrence in various metabolic diseases such as cancer, heart disease, diabetes, and brain disease. Most glucose that enters a cell is shuttled through glycogen prior to...

Research Terms

<Acid Maltase Deficiency Disease><Autophagocytosis><Brain Diseases><Brain Disorders><Cancers><Cardiac Diseases><Cardiac Disorders><Cell Body><Cells><Cellular Metabolic Process><Cellular biology><Cytosol><D-Glucose><Danon Disease><Dextrose><Diabetes Mellitus><Diagnosis><Disease><Disorder><Encephalon Diseases><Enzyme Gene><Enzymes><Freedom><Generalized Glycogenosis><Genetic Diseases><Glucose><Glycogen><Glycogen Debranching Enzyme><Glycogen Phosphorylase><Glycogen Storage Disease IIb><Glycogen Storage Disease Type IIb><Glycogen storage disease type II><Glycogenosis 2><Glycogenosis Type II><Goals><Grant><Grips><Health><Heart Diseases><Influentials><Intermediary Metabolism><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Knowledge><Liberty><Lysosomal Enzyme Disorders><Lysosomal Storage Diseases><Lysosomal alpha-1,4-Glucosidase Deficiency Disease><Lysosomes><Malignant Neoplasms><Malignant Tumor><Mediating><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolism><Mice><Mice Mammals><Murine><Mus><Pathway interactions><Phosphorylase ab><Pompe Disease><Process><Research><Role><Shunt><Shunt Device><Sight><Thesaurismosis><Translating><Vision><Work><X Linked Vacuolar Cardiomyopathy and Myopathy><acid maltase deficiency><alpha 1,4 glucosidase deficiency><autophagy><cell biology><cell metabolism><cellular metabaolism><diabetes><flexibility><flexible><genetic condition><genetic disorder><genetically engineered cells><genetically modified cells><glucose metabolism><glycogen metabolism><glycogenolysis><grasp><heart disorder><inborn lysosomal enzyme disorder><innovate><innovation><innovative><lysosomal disease><lysosomal disorder><lysosome storage diseases><malignancy><metabolism disorder><neoplasm/cancer><novel><pathway><shunts><social role><tool><visual function>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JOHN A. PORCO

BOSTON UNIVERSITY (CHARLES RIVER CAMPUS), BOSTON, MA

Exploratory lead · 36/100
Likely hiring
Active award
$25,732
FY 2025

Project Title

Chemical Synthesis of Complex Natural Products for Translational Science

Grant Number:

3R35GM118173-10S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2016

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Chemical Synthesis of Complex Natural Products for Translational Science The goals of the continuing MIRA (R35GM118173) research program are to continue focus on chemical syntheses of bioactive molecules for translational studies. The MIRA effort will allow flexibility and stability ...

Research Terms

<9-Oxoxanthene><Address><Alkaloids><Biological><Biological Mimetics><Biomimetics><Cancers><Catalysis><Clinical><Clinical Research><Clinical Study><Collaborations><Complex><Development><Drug Therapy><Goals><Human><Investigation><Investigators><Ions><Journals><Magazine><Malignant Neoplasms><Malignant Tumor><Manuscripts><Methodology><Methods><Modern Man><Natural Products><Organic Chemistry><Pharmacological Treatment><Pharmacotherapy><Principal Investigator><Productivity><Property><Public Health><Publications><Pyrrolo-Iminoquinones><Pyrroloiminoquinones><Reaction><Research><Research Personnel><Researchers><Scientific Publication><Translational Research><Translational Science><Translations><Trichothecenes><Viral><Work><Xanthones><bioactive natural products><biologic><chemical synthesis><cycloaddition><developmental><dimer><drug intervention><drug treatment><flexibility><flexible><inhibitor><innovate><innovation><innovative><malignancy><naturally occurring product><neoplasm/cancer><novel><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><professor><programs><translation><translation research><translational investigation><translational study>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Hiroyuki Takai

ROCKEFELLER UNIVERSITY, NEW YORK, NY

Exploratory lead · 10/100
Active award
$170,761
FY 2025

Project Title

The interplay of the CST complex and telomerase at human telomeres

Grant Number:

5R50CA243771-07

Activity Code:

R50

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/17/2019

End Date:

8/31/2029

Project Abstract

Project Summary/Abstract This R50 proposal is a companion to our recently renewed R35 (CA210036-08), which is focused on the role of telomeres in cancer. Telomeres are required for the survival and proliferation of human cells and play a critical role in cancer. Excessively long telomeres at birth p...

Research Terms

<Binding><Birth><Bypass><Cancers><Cell Body><Cell Compartmentation><Cell Compartmentations><Cell Cycle Arrest><Cells><Coats plus disease><Coats plus syndrome><Cole syndrome><Cole-Rauschkolb-Toomey syndrome><Collaborations><Companions><Complex><Creativeness><Cryo-electron Microscopy><Cryoelectron Microscopy><DNA><DNA Primase><DNA Replication><DNA Synthesis><DNA biosynthesis><Data><Deoxyribonucleic Acid><Dephosphorylation><Dyskeratosis Congenita><Electron Cryomicroscopy><Engman syndrome><Goals><Human><In Vitro><Kinases><Knowledge><Length><MOF syndrome><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mediating><Modern Man><Molecular Interaction><Multiple Organ Dysfunction Syndrome><Multiple Organ Failure><Oncogenesis><Parturition><Pathway interactions><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Play><Primase><Progenitor Cells><Proliferating><Protein Dephosphorylation><Protein Phosphorylation><Regulation><Research><Role><Single-Stranded DNA><Structure><Syndrome><Telomerase><Telomere Maintenance><Telomere Shortening><Transphosphorylases><Tumor Suppressor Proteins><X-Linked Dyskeratosis Congenita><Zinsser syndrome><Zinsser-Engman-Cole syndrome><cancer cell><cancer predisposition><career><congenital dyskeratosis><creativity><cryo-EM><cryoEM><cryogenic electron microscopy><disabled><experiment><experimental research><experimental study><experiments><graduate student><in vivo><innovate><innovation><innovative><insight><malignancy><member><multiorgan failure><multiple organ system failure><neoplasm/cancer><new technology><novel technologies><pathway><prevent><preventing><programs><recruit><response><skills><social role><ssDNA><stem cells><success><telomere><telomere attrition><telomere loss><telomeric loss><tumor suppressor><tumorigenesis>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Search NIH grants by PI name

Looking for a specific principal investigator? The keyword search above looks up funded projects by topic. To search NIH grants by PI name (last name, first + last name, or partial name) and see every active and recent NIH award for that researcher, use the dedicated PI Funding Status tool.

How to Use PI Funding Data for Career Decisions

Finding the right principal investigator is one of the most important decisions in an academic career. Whether you are a postdoc looking for a mentor, a graduate student choosing a rotation lab, or a collaborator seeking a co-PI, NIH funding data provides objective signals about which investigators have active research programs and resources to support new team members.

A PI with a recently awarded R01 or equivalent grant is more likely to have budget for new personnel than one whose funding ended two years ago. The activity code tells you the type of grant: R01 and R35 awards typically support multiple lab members, while K-series awards are individual career development grants that may not fund additional positions. Understanding these distinctions helps you interpret search results accurately.

Look beyond the dollar amount. A $500,000 per year R01 at a high-cost institution may support fewer positions than a $300,000 award at a university with lower overhead rates. The project abstract and public health relevance statement reveal whether the PI's research direction aligns with your interests and expertise.

Understanding PI Grant Portfolios

A PI's grant portfolio reveals more than individual awards. Investigators with multiple active grants often run larger labs with more diverse projects, which can mean more opportunities for trainees. However, a PI with a single well-funded grant may offer more focused mentorship and a clearer path to publications.

Multi-PI grants (those with more than one principal investigator listed) indicate collaborative research and may involve trainees from multiple institutions. These can be excellent opportunities for interdisciplinary training but may also mean split attention from any single mentor.

Pay attention to the timing of awards. A PI who just received a new five-year R01 is in a different position than one whose grant ends next year. New awards often correspond to lab expansion and active recruiting, making them ideal targets for job seekers. The start and end dates shown in each result help you assess this timing.

Best Practices for Contacting Funded PIs

Once you identify a promising PI through this tool, the next step is outreach. NIH public records do not include email addresses, but you can usually find contact information through the PI's institutional profile page, lab website, or recent publications. Google Scholar, PubMed, and the PI's department website are reliable starting points.

When reaching out, reference the specific grant that caught your attention. Mentioning the project title and explaining how your skills relate to the funded work shows that you have done your homework. Keep your initial message concise: introduce yourself, explain your interest, attach your CV, and ask whether they anticipate openings.

Timing matters. Contacting a PI within the first year of a new award is ideal, as this is when they are most likely to be recruiting. If you find multiple promising PIs in the same field, prioritize those with the most recent award notices and activity codes that support trainee positions such as R01, U01, or P-series grants.

Frequently Asked Questions About PI Search

What does the opportunity score mean?

The opportunity score is a heuristic that combines award recency, funding amount, activity code type, and project characteristics to estimate how actionable a result might be for job seekers or collaborators. Higher scores suggest stronger signals, but always verify by reading the abstract and checking the PI's current lab page.

Why can't I find a PI I know has funding?

Name variations are the most common cause. Try searching with just the last name, or use different formats like "Smith, John" versus "John Smith." Some PIs also publish under different name variations or may have awards under a previous institutional affiliation.

Does this tool show all NIH-funded PIs?

The tool searches NIH RePORTER data for the keyword and year range you specify. It returns PIs whose funded projects match your search terms. PIs with grants in unrelated areas or whose projects use different terminology will not appear in keyword-filtered results.

What is the difference between "Likely hiring" and "Training-friendly" filters?

"Likely hiring" flags PIs with large new awards or activity codes typically associated with lab expansion. "Training-friendly" identifies awards that include training components or are at institutions known for postdoctoral programs. Both are heuristic filters to help prioritize your outreach.

How to use this well

Start broad, then narrow. Search a field first, then refine by timeframe once you understand who is currently active.

After you find a promising PI, cross-check them in Check PI Funding and review their institution, mechanism type, and project abstracts before reaching out.

What a match means

A result means the keyword appears relevant to the funded project data we searched. It does not guarantee the PI is hiring or that the grant is still active.

Use the abstract, award year, mechanism, and organization context to decide whether the record is strategically relevant.

Data limits

NIH records can lag, institutional names can vary, and some investigators publish or file awards under multiple name formats.

For details on source coverage and refresh cadence, read Data & Methodology.

Related guides

Companion guides for turning a PI search result into useful outreach or a job lead.

Career Guide8 min read

How Postdocs Can Find PIs with New NIH Funding

A tactical job-search guide for identifying recently funded labs, judging fit, and timing outreach to principal investigators.

Read guide
Career Guide7 min read

How to Contact a PI: Finding Emails and Crafting the Perfect Message

Emailing strategies, outreach examples, and a workflow for turning NIH funding signals into focused PI conversations.

Read guide
Career Guide10 min read

How to Read a New NIH Award Like a Hiring Signal

A practical framework for using newly funded NIH awards to judge whether a lab may be expanding, hiring, or worth contacting now.

Read guide
Funding Strategy16 min read

How to Find NIH Funding Opportunities: A Step-by-Step Guide for Researchers

Learn how to find NIH funding opportunities using the NIH Guide, Grants.gov, FOAs, NIH RePORTER, and program officer outreach.

Read guide

Recently Funded Labs in Trending Areas

Principal investigators who received NIH awards in the last 90 days, organized by research area. Use this as a starting point for postdoc searches, collaborator outreach, or competitor scans. Counts and labs refresh daily.

Alzheimer's disease

Neurodegeneration, biomarkers, and disease-modifying therapies.

  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $101,153 · awarded Feb 25, 2026 · 3U01AG084514-01A1S1
  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $3,086,339 · awarded Feb 19, 2026 · 1U01AG084514-01A1
  • HARALD SONTHEIMER — UNIVERSITY OF VIRGINIA, VA
    Extracellular matrix and memory impairments in Alzheimer disease
    $709,066 · awarded Apr 7, 2026 · 5R01AG085359-03
  • Keith Josephs — MAYO CLINIC ROCHESTER, MN
    The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies
    $643,670 · awarded Apr 1, 2026 · 5R01DC014942-09
  • DMITRIY YABLONSKIY — WASHINGTON UNIVERSITY, MO
    Deep-Learning-Augmented Quantitative Gradient Recalled Echo (DLA-qGRE) MRI for in vivo Clinical Evaluation of Brain Microstructural Neurodegeneration in Alzheimer Disease
    $661,985 · awarded Mar 3, 2026 · 4R01AG082030-02
Search more PIs in Alzheimer's disease →

CRISPR & gene editing

Therapeutic gene editing, base editing, and prime editing.

  • Changchun Liu — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT
    Asymmetric CRISPR Approach for Nucleic Acid Quantification
    $643,849 · awarded Mar 30, 2026 · 2R01EB023607-06A1
  • William Pu — BOSTON CHILDREN'S HOSPITAL, MA
    A modular system for murine CRISPR genome and epigenome editing
    $267,000 · awarded Mar 27, 2026 · 5R21OD037909-02
  • Naama Aviram — SLOAN-KETTERING INST CAN RESEARCH, NY
    Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systems
    $249,000 · awarded Apr 2, 2026 · 5R00GM148720-04
  • Mats Ljungman — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Precision targeting of bladder cancer using CRISPR
    $582,849 · awarded Feb 17, 2026 · 5R01CA285730-03
  • Shannon Miller — SCRIPPS RESEARCH INSTITUTE, THE, CA
    Development of potent and safe CRISPR tools for in vivo gene editing using directed evolution
    $230,000 · awarded May 5, 2026 · 5R21EB036298-03
Search more PIs in CRISPR & gene editing →

Cancer immunotherapy

Checkpoint inhibitors, CAR-T, TIL therapy, and beyond.

  • TERRY SHEPPARD — KEYSTONE SYMPOSIA, CO
    Cancer Immunotherapy: Basic Mechanisms Informing Clinical Applications & Combinations
    $5,000 · awarded Mar 3, 2026 · 1R13CA310704-01
  • Veronika Fedirko — UNIVERSITY OF TX MD ANDERSON CAN CTR, TX
    Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma
    $927,329 · awarded Mar 3, 2026 · 5R01CA255322-05
  • Yuwen Zhu — UNIVERSITY OF COLORADO DENVER, CO
    The GPR171 pathway in cancer immunotherapy
    $355,706 · awarded Apr 2, 2026 · 5R01CA279398-04
  • ANDREW WIEMER — UNIVERSITY OF CONNECTICUT STORRS, CT
    Synthesis and evaluation of BTN3A1 ligands for cancer immunotherapy
    $374,171 · awarded May 1, 2026 · 5R01CA266138-05
  • Wei Hu — YALE UNIVERSITY, CT
    Novel Treg inactivating approach for cancer immunotherapy via targeted protein degradation
    $482,312 · awarded Apr 6, 2026 · 1R01CA295942-01A1
Search more PIs in Cancer immunotherapy →

GLP-1 & metabolic disease

Diabetes, obesity, and weight-loss therapeutic mechanisms.

  • ZHIPING PANG — RUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ
    Synaptic and circuit mechanisms of central GLP-1 signaling in energy balance
    $479,051 · awarded Apr 23, 2026 · 5R01DK131452-05
  • Madhusmita Misra — UNIVERSITY OF VIRGINIA, VA
    Bone metabolism in adolescents undergoing GLP-1 receptor agonist therapy
    $471,776 · awarded Apr 24, 2026 · 5R01HD118635-07
  • STEVEN SCHWENDEMAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Remote Loading of Melanocortin and GLP-1 Peptides in Polymers for Treatment of Obesity
    $231,000 · awarded Apr 17, 2026 · 1R56DK141545-01A1
  • Jessica Barson — DREXEL UNIVERSITY, PA
    Suppression of ethanol dependence-induced maladaptive appetitive and consummatory behavior by the GLP-1 system
    $564,306 · awarded May 5, 2026 · 1R01AA031732-01A1
  • MICHAEL CAMILLERI — MAYO CLINIC ROCHESTER, MN
    A Randomized, placebo-controlled trial of the effects of Long-Acting GLP-1 or Dual Incretin (GLP-1 and GIP) Modulation on Gastrointestinal Functions and Relationship to Weight Loss
    $322,800 · awarded Apr 9, 2026 · 5R01DK142606-02
Search more PIs in GLP-1 & metabolic disease →

Long COVID

Post-acute sequelae and chronic infection-driven illness.

  • Alexei Tumanov — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX
    Lymphotoxin-dependent control of long COVID
    $234,715 · awarded Feb 13, 2026 · 1R21AI185790-01A1
  • Amal Amer — OHIO STATE UNIVERSITY, OH
    Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
    $2,974,582 · awarded Apr 21, 2026 · 5P01AI175399-03
  • Alba Azola — JOHNS HOPKINS UNIVERSITY, MD
    Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 onset ME/CFS versus Pre-Pandemic ME/CFS Patients
    $633,378 · awarded Apr 17, 2026 · 1R01NS147100-01
  • DANIELLE REED — MONELL CHEMICAL SENSES CENTER, PA
    Inflammation and chemosensory loss
    $2,654,249 · awarded Feb 26, 2026 · 1P50DC022549-01A1
  • Jarred Younger — UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL
    Low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
    $556,686 · awarded Mar 6, 2026 · 1UG3NS141843-01A1
Search more PIs in Long COVID →