KK Series — Career Development

NIH K25 Grants — Mentored Quantitative Research Career Development Award

Reviewed by Dr. Meng ZhaoLast reviewed June 9, 2026Data refreshed September 5, 2026Editorial standards

Brings quantitative scientists (engineers, physicists) into biomedical research

Funding

Salary support + research support

Duration

3–5 years

Eligibility

Quantitative scientists transitioning to biomedical research

Activity code

K25

What is the NIH K25 grant?

The K25 funds engineers, physicists, computer scientists, and other quantitative researchers who want to apply their skills to biomedical research questions and need mentored training in a biomedical context.

Recent K25 awards from NIH RePORTER

Examples of funded K25 projects across the last two fiscal years. The matching-award count comes from the full result set; funding totals, averages, rankings, and examples use the first 500 records returned by NIH RePORTER. Figures reflect a snapshot last refreshed on September 5, 2026.

Matching awards (last 2 FYs)
107
Full matching record count on RePORTER
Sampled funding
$15.6M
Sum of award amounts in the sample
Average award
$146K
Mean award amount in the sample

Example K25 projects from the sample

  • Intelligent Bioelectronic Implants for the Diagnosis and Neuromodulation of Neurogenic Bladder Dysfunction

    1K25DK144708-01A1
    Zhengwei Li · UNIVERSITY OF HOUSTON, TX · $167,696 · awarded Aug 27, 2026 · NIH

    Project Summary Urological dysfunction following spinal cord injury (SCI) often includes neurogenic bladder and detrusor sphincter dyssynergia (DSD), where the external urethral sphincter (EUS) fails to relax during detrusor muscle contraction, resulting in inefficient bladder emptying. Unfortunately, current treatments—including pharmacotherapy, botulinum…

  • Optimizing Congenital Aortic Valve Surgery with Simulation-Guided Design

    5K25HL175208-03
    Alexander Kaiser · STANFORD UNIVERSITY, CA · $181,872 · awarded Aug 21, 2026 · NIH

    PROJECT SUMMARY Congenital heart disease occurs in about 1% of births, making it the most common type of birth defect and leading cause of infant mortality in the United States. Congenital aortic valve disease, one category of congenital heart disease, frequently requires surgery. Despite generally positive results, undesirable outcomes remain common, and…

  • Multi-omic network methods for mapping molecular trajectories of age-related lung diseases

    7K25HL175222-02
    Katherine Shutta · UNIVERSITY OF MARYLAND BALTIMORE, MD · $126,322 · awarded Aug 20, 2026 · NIH

    Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are progressive lung diseases that are substantial sources of morbidity and mortality worldwide. Both diseases have common origins beginning with injury to the lung from environmental exposures such as cigarette smoke or particulates from biomass fuels. However, people with…

  • Translational XR and AI Technologies with Dynamic Soft Robotic Hearts for Immersive Clinical Training and Future Intraoperative Guidance in Interventional Cardiology

    1K25HL186244-01
    Mohsen Annabestani · WEILL MEDICAL COLL OF CORNELL UNIV, NY · $100,805 · awarded Aug 19, 2026 · NIH

    Project Summary This K25 project aims to revolutionize structural heart intervention training and procedural guidance by developing an advanced extended reality (XR) platform integrated with AI, soft robotics, and fluoroscopy- compatible systems to address critical clinical challenges in procedures like atrial septal defect (ASD) closure, left atrial…

  • Ultra-Low Field MRI for Assessment of Congenital Heart Disease

    1K25HL183904-01A1
    Jonathan Martin · VANDERBILT UNIVERSITY MEDICAL CENTER, TN · $174,621 · awarded Aug 19, 2026 · NIH

    PROJECT SUMMARY/ABSTRACT Objective: The goal of this research is to develop cardiac magnetic resonance imaging (CMR) techniques for monitoring congenital heart disease (CHD) that are more robust, safe, and accessible than conventional CMR, which is performed at high magnetic field strengths. I will achieve this by implementing CMR on an ultra-low field…

  • Roles of Red Blood Cell Derived Extracellular Vesicles in Complement Activation and Thromboinflammation in sickle cell disease

    5K25HL159358-05
    Ran An · UNIVERSITY OF HOUSTON, TX · $106,486 · awarded Aug 17, 2026 · NIH

    PROJECT SUMMARY Sickle cell disease (SCD) is caused by abnormal polymerization of deoxygenated sickle hemoglobin, which damages red blood cells (RBCs), resulting in hemolysis and thromboinflammation. Sickled-RBCs lead to heterogeneous clinical complications in SCD and induce challenges in determining the exact therapeutic interventions. Extracellular…

  • Using Microfluidics to Identify Mechanisms of Platelet Dysfunction and Assess Therapeutic Efficacy in Traumatic Hemorrhage

    5K25HL161401-05
    Susan Shea · UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PA · $128,072 · awarded Aug 17, 2026 · NIH

    This proposal consists of a five-year plan to develop Susan M. Shea, PhD into an independent translational scientist in the field of trauma-induced coagulopathy (TIC) and therapeutic assessment of hemostatic blood products. The University of Pittsburgh (Pitt) is an outstanding institution for Dr. Shea to establish her research program, as there is a…

  • Correlating Genotype and Phenotype of Metastatic Cancer Cells In Vivo Using Nanolaser Optical Barcode

    7K25CA301033-02
    Sangyeon Cho · RICE UNIVERSITY, TX · $23,525 · awarded Aug 7, 2026 · NIH

    Project Summary. The complex dynamics of metastatic cancer, which include processes like plasticity, immune evasion, and therapy resistance, pose significant challenges to effective treatment. While emerging single-cell sequencing technologies now aid in understanding the unique genome expression of individual cancer cells within heterogeneous tumor…

  • Statistical physics and network-based approaches for elucidating molecular biomarkers of COPD

    5K25HL166208-04
    Xuwen Wang · BRIGHAM AND WOMEN'S HOSPITAL, MA · $189,000 · awarded Aug 7, 2026 · NIH

    PROJECT SUMMARY Chronic obstructive pulmonary disease (COPD) is a chronic inflammatory lung disease that causes obstructed airflow from the lungs. As a common complex disease, COPD has high global morbidity and mortality. Indeed, deaths due to respiratory disease numbered nearly four million, which was mostly contributed by COPD. There is a clear demand to…

  • Machine learning-based methods for phenotyping dementia patients from electronic health record data

    5K25AG083064-04
    Roy Adams · JOHNS HOPKINS UNIVERSITY, MD · $136,001 · awarded Aug 6, 2026 · NIH

    PROJECT SUMMARY/ABSTRACT Candidate: Dr. Roy Adams applies for this K25 Mentored Quantitative Research Career Development Award with the goal of building a productive independent research career as a methodologist focused on developing electronic health record (EHR)-based models and tools to improve our understanding of Alzheimer’s disease and related…

  • Mechanogenomics of the asthmatic airway epithelium

    5K25HL168157-04
    Margherita De Marzio · BRIGHAM AND WOMEN'S HOSPITAL, MA · $188,920 · awarded Aug 3, 2026 · NIH

    Summary/Abstract Airway wall remodeling is one of the most documented hallmarks of asthma. Despite being a key clinical trait of long-term asthma, this pathological condition remains largely uncontrolled even with front-line therapies. Remodeling processes have been traditionally described as an aberrant response to chronic inflammation. However, this…

  • Predicting symptom onset and clinical progression with blood biomarkers of Alzheimer disease

    1K25AG095391-01A1
    Kellen Petersen · WASHINGTON UNIVERSITY, MO · $151,480 · awarded Aug 3, 2026 · NIH

    PROJECT SUMMARY This Mentored Quantitative Research Career Development Award consists of an integrated career development plan and research project designed to enable Dr. Kellen Petersen to become an independent investigator focused on applying advanced mathematical and computational models to the study of Alzheimer Disease (AD) and blood-based biomarkers.…

Funding institutes in the sample

InstituteAwardsFunding
NIH107$15.6M

Most frequent institutions in the sample

  1. BRIGHAM AND WOMEN'S HOSPITAL — 11 awards
  2. JOHNS HOPKINS UNIVERSITY — 6 awards
  3. MASSACHUSETTS GENERAL HOSPITAL — 6 awards
  4. COLUMBIA UNIVERSITY HEALTH SCIENCES — 6 awards
  5. WAKE FOREST UNIVERSITY HEALTH SCIENCES — 5 awards
  6. UNIVERSITY OF FLORIDA — 5 awards
  7. WEILL MEDICAL COLL OF CORNELL UNIV — 4 awards
  8. ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI — 4 awards

Source: NIH RePORTER. Verify any award in the official record by searching its project number. See our data methodology for how this sample is built and its limitations.

Decision guide

Choose K25 when

Choose K25 if your terminal degree is outside biomedical sciences and you need mentored time to learn the biomedical domain.

Choose another mechanism when

PhDs already trained in biomedical research should use K01 or K99/R00.

Who applies for K25

PhDs in engineering, physics, mathematics, computer science, etc., looking to transition into biomedical research.

Compare nearby NIH grant mechanisms

Searchers often land on K25 while deciding between adjacent NIH activity codes. Compare scope, NIH staff involvement, budget scale, and applicant stage before choosing a funding opportunity.

For broad grant lookup, use the NIH grant search to find funded examples by activity code, PI, institution, and award year.

Search tips for K25

  • K25 PIs often anchor computational and engineering departments at AMCs.

Open NIH NOFOs for K25

NIH accepts K25 applications only through a notice of funding opportunity (NOFO). These 2 are open or opening soon; each page lists due dates, participating institutes, related notices, and the projects NIH funded under it.

See all open K25 NOFOs

Search NIH grants by activity code

Find K25-funded PIs

K25 funding trends

Related NIH grant types