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Found 256 principal investigators from 200 displayed projects for "microbiome" (2021–2026)

Note: 11,284 projects matched but only the first 200 were analyzed. Try narrowing your search with a more specific term or selecting "Project title only".

Opportunity Digest

Heuristic scoring to help trainees and job seekers prioritize which labs to inspect first.

35

High-opportunity leads

152

Likely hiring signals

46

Training-friendly awards

54

Average opportunity score

Prioritize records with strong opportunity signals, then validate fit using abstracts, institution pages, and lab websites.

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Kirsi Jarvinen-Seppo

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

High-opportunity lead · 88/100
Likely hiring
Large award
Very recent
Active award
$1,391,926
FY 2026

Project Title

Biomarkers of Atopy Beginning Early (BABE)

Grant Number:

5U19AI175113-04

Activity Code:

U19

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/7/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT – OVERALL Atopic dermatitis (AD) often precedes sensitization to food allergens and the development of clinical food allergy (FA) due to compromised skin barrier function allowing allergen sensitization through skin. A large body of data from Europe and North America suggest...

Research Terms

<0-11 years old><5 year old><5 years of age><Allergens><Allergic><Allergic Disease><Allergic asthma><Allergic to food><Allergy><Allergy to food><Asthma><Atopic Allergy><Atopic Dermatitis><Atopic Eczema><Atopic Neurodermatitis><Bathing><Baths><Bioinformatics><Bioinformatics core><Bioinformatics research core><Bioinformatics resource core><Biological Markers><Birth><Blood><Blood Reticuloendothelial System><Blood monocyte><Bronchial Asthma><Cell Body><Cells><Child><Child Youth><Childhood><Children (0-21)><Clinical Data><Cluster Analyses><Cluster Analysis><Consumption><Data><Development><Diet><Disease><Disorder><Disseminated Neurodermatitis><Eating><Epithelial Cells><Europe><Exposure to><Extrinsic asthma><Family><Farm><Farm Animal><Feces><Food Allergy><Food Hypersensitivity><Food Intake><Foundations><Funding><Future><GI microbiome><Generations><Grant><Home><Homing><House Dust><Human><Immune><Immune Markers><Immune response><Immune system><Immunes><Immunologic Markers><Impairment><Incidence><Individual><Infant><Inflammation><Inflammatory><Infrastructure><Innate Immune System><Innate Immunity><Knowledge><L-Tryptophan><Lead><Levotryptophan><Life><Life Style><Lifestyle><Livestock><Marrow monocyte><Memory><Mennonite><Milk><Modern Man><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><North America><Organization Charts><Parturition><Pb element><Permeability><Population><Prevention><Production><Regulatory T-Lymphocyte><Risk><Sampling><Short-Chain Fatty Acids><Skin><Swab><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><TSLP><TSLP gene><Testing><Thymic Stromal Lymphopoietin><Training><Treg><Tryptophan><Volatile Fatty Acids><adaptive immunity><age 5><age 5 years><allergic dermatitis><allergic eczema><atopic asthma><atopic triad><atopy><bio-markers><biobank><biologic marker><biomarker><biomarker identification><biorepository><birth cohort study><birth cohort survey><clinical development><cohort><comparator group><comparison group><cutaneous barrier><cutaneous microbiome><cytokine><data management><dermal barrier><dermal microbiome><developmental><diets><digestive tract microbiome><early childhood><early onset><enteric microbiome><epidermal barrier><epidermal microbiome><extrinsic allergic asthma><five year old><five years of age><food allergen><gastrointestinal microbiome><global gene expression><global transcription profile><gut microbiome><gut microbiome of infant><gut-associated microbiome><heavy metal Pb><heavy metal lead><high risk><high risk infant><home dust><homes><host response><household dust><identification of biomarkers><identification of new biomarkers><immune system response><immune-based biomarkers><immunological biomarkers><immunological markers><immunoresponse><individualized prevention><infancy><infant gut microbiome><infantile><intestinal biome><intestinal microbiome><kids><marker identification><metabolome><metabonome><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><monocyte><neonate gut microbiome><newborn gut microbiome><organizational structure><pediatric><personalized prevention><precision prevention><preservation><programs><recruit><regulatory T-cells><residential dust><respiratory><sample collection><skin barrier><skin biome><skin microbiome><specimen collection><stool><thymus derived lymphocyte><transcriptome><transcriptomics><unpasteurized><urban children><vulnerable infant><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

ERIK R DUBBERKE

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 82/100
Likely hiring
Above-average budget
Very recent
Active award
$919,820
FY 2026

Project Title

Phase 1b/2a Evaluation of the Safety and Tolerability of SYN-004 in Adult Allogeneic Hematopoietic Cell Transplantation (allo-HCT) Recipients

Grant Number:

1U01AI195139-01

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Arguably one of the greatest medical breakthroughs in the 20th century was the introduction of antibiotics into clinical use. Soon afterwards several downsides to antibiotics were recognized, including antibiotic-associated colitis (now known to be due to Clostridioides difficile) and emerg...

Research Terms

<21+ years old><AR gene><Adult><Adult Human><Allogenic><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotic Therapy><Antibiotic Treatment><Antibiotic-Associated Colitis><Antibiotic-resistant organism><Antibiotics><Architecture><C diff><C difficile><C. diff><C. difficile><Candida><Cefatriaxone><Cefepime><Ceftriaxone><Cessation of life><Clinical><Clinical Trials><Clostridioides difficile><Clostridium difficile><Data><Death><Dihydrotestosterone Receptor><Dose><Drug Kinetics><Engineering / Architecture><Enzyme Gene><Enzymes><Evaluation><Excretory function><Feces><G24 protein><GI colonization><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Taxonomy><Generalized Growth><Growth><Gut Mucosa><HSC transplantation><Health><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Human><Hydrolysis><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><Incidence><Indican><Individual><Indoxyl Sulfate><Infection><Infection prevention><Measures><Medical><Metabolic><Miscellaneous Antibiotic><Modern Man><Modern Medicine><Monilia><Motivation><Mucosa><Mucosal Tissue><Mucous Membrane><NR3C4><Oral Administration><Oral Drug Administration><Organism><Participant><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Persons><Pharmacokinetics><Phase><Phase 2 Clinical Trials><Phase 3 Clinical Trials><Phase II Clinical Trials><Phase III Clinical Trials><Placebo Control><Placebos><Population><Prevent infection><Prevention><Public Health><Randomized><Recombinants><Research><Resistance><Resistance to antibiotics><Resistant to antibiotics><Risk><SMAX1><Safety><Sham Treatment><Shotgun Sequencing><Shotguns><Target Populations><Taxonomy><Therapeutic><Time><Tissue Growth><Transmission><Transplant Recipients><Transplantation Conditioning><Treatment Failure><Vancomycin resistant enterococcus><Vancomycin-resistant enterococci><Work><absorption><adulthood><alter microbiome><androgen receptor gene><antibiotic drug resistance><antibiotic resistant><bacterial disease treatment><bacterial infectious disease treatment><beta lactam antibiotic><beta lactam hydrolase><beta-Lactamase><beta-Lactamhydrolase><beta-Lactams><blood stem cell transplantation><cefepim><chemotherapy><colonization resistance><combat><conditioning><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><excretion><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><immunosuppressed patient><improved outcome><innovate><innovation><innovative><interest><intestinal biome><intestinal colonization><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intraoral drug delivery><living system><metagenome sequencing><metagenomic sequencing><microbiome><microbiome adaptation><microbiome alteration><microbiome community composition><microbiome composition><microbiome perturbation><microbiome species composition><microbiome structure><multi-modality><multimodality><new approaches><novel approaches><novel strategies><novel strategy><ontogeny><patient oriented outcomes><patient population><phase 3 trial><phase II protocol><phase III protocol><phase III trial><placebo controlled><preservation><prevent><preventing><primary outcome><protective effect><randomisation><randomization><randomly assigned><resistant><sham therapy><shot gun><stool><therapy failure><transmission process><transplant patient><urgent antibiotic resistance><urgent antibiotic resistant><urinary><vancomycin resistance enterococci><vancomycin resistance in enterococci><β lactam antibiotic><β-Lactamase><β-Lactams>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Gautam Dantas

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 82/100
Likely hiring
Above-average budget
Very recent
Active award
$919,820
FY 2026

Project Title

Phase 1b/2a Evaluation of the Safety and Tolerability of SYN-004 in Adult Allogeneic Hematopoietic Cell Transplantation (allo-HCT) Recipients

Grant Number:

1U01AI195139-01

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Arguably one of the greatest medical breakthroughs in the 20th century was the introduction of antibiotics into clinical use. Soon afterwards several downsides to antibiotics were recognized, including antibiotic-associated colitis (now known to be due to Clostridioides difficile) and emerg...

Research Terms

<21+ years old><AR gene><Adult><Adult Human><Allogenic><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotic Therapy><Antibiotic Treatment><Antibiotic-Associated Colitis><Antibiotic-resistant organism><Antibiotics><Architecture><C diff><C difficile><C. diff><C. difficile><Candida><Cefatriaxone><Cefepime><Ceftriaxone><Cessation of life><Clinical><Clinical Trials><Clostridioides difficile><Clostridium difficile><Data><Death><Dihydrotestosterone Receptor><Dose><Drug Kinetics><Engineering / Architecture><Enzyme Gene><Enzymes><Evaluation><Excretory function><Feces><G24 protein><GI colonization><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Taxonomy><Generalized Growth><Growth><Gut Mucosa><HSC transplantation><Health><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Human><Hydrolysis><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><Incidence><Indican><Individual><Indoxyl Sulfate><Infection><Infection prevention><Measures><Medical><Metabolic><Miscellaneous Antibiotic><Modern Man><Modern Medicine><Monilia><Motivation><Mucosa><Mucosal Tissue><Mucous Membrane><NR3C4><Oral Administration><Oral Drug Administration><Organism><Participant><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Persons><Pharmacokinetics><Phase><Phase 2 Clinical Trials><Phase 3 Clinical Trials><Phase II Clinical Trials><Phase III Clinical Trials><Placebo Control><Placebos><Population><Prevent infection><Prevention><Public Health><Randomized><Recombinants><Research><Resistance><Resistance to antibiotics><Resistant to antibiotics><Risk><SMAX1><Safety><Sham Treatment><Shotgun Sequencing><Shotguns><Target Populations><Taxonomy><Therapeutic><Time><Tissue Growth><Transmission><Transplant Recipients><Transplantation Conditioning><Treatment Failure><Vancomycin resistant enterococcus><Vancomycin-resistant enterococci><Work><absorption><adulthood><alter microbiome><androgen receptor gene><antibiotic drug resistance><antibiotic resistant><bacterial disease treatment><bacterial infectious disease treatment><beta lactam antibiotic><beta lactam hydrolase><beta-Lactamase><beta-Lactamhydrolase><beta-Lactams><blood stem cell transplantation><cefepim><chemotherapy><colonization resistance><combat><conditioning><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><excretion><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><immunosuppressed patient><improved outcome><innovate><innovation><innovative><interest><intestinal biome><intestinal colonization><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intraoral drug delivery><living system><metagenome sequencing><metagenomic sequencing><microbiome><microbiome adaptation><microbiome alteration><microbiome community composition><microbiome composition><microbiome perturbation><microbiome species composition><microbiome structure><multi-modality><multimodality><new approaches><novel approaches><novel strategies><novel strategy><ontogeny><patient oriented outcomes><patient population><phase 3 trial><phase II protocol><phase III protocol><phase III trial><placebo controlled><preservation><prevent><preventing><primary outcome><protective effect><randomisation><randomization><randomly assigned><resistant><sham therapy><shot gun><stool><therapy failure><transmission process><transplant patient><urgent antibiotic resistance><urgent antibiotic resistant><urinary><vancomycin resistance enterococci><vancomycin resistance in enterococci><β lactam antibiotic><β-Lactamase><β-Lactams>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jordan Adam Bisanz

PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$2,864,424
FY 2026

Project Title

Environmental PFAS alter microbial function, impair host metabolism, and drive disease progression

Grant Number:

1R01ES038206-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/4/2026

End Date:

4/3/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants known for their widespread use and adverse effects on human health (e.g., metabolic disease, cancer). Early-life exposure to PFAS is of particular concern as developmental periods are a critical window of vul...

Research Terms

<0-11 years old><21+ years old><Address><Adult><Adult Human><Adverse effects><Affect><Age><Automobile Driving><Autoregulation><Biometrics><Biometry><Biostatistics><Body Tissues><Breast Milk><Breastmilk><Cancers><Cell Body><Cells><Chemical Exposure><Chemicals><Child><Child Youth><Children (0-21)><Chronic><Communities><Contamination in food><DNA mutation><Data><Development><Diet><Disease Progression><Drug resistance><Enterococcus><Environmental Factor><Environmental Pollutants><Environmental Risk Factor><Environmental Toxin><Evolution><Exposure to><Food Contamination><Functional Metagenomics><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Transcription><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Grant><Health><Hepatic Disorder><High Throughput Assay><Homeostasis><Human><Human Milk><Human Mother's Milk><Hydrogen Oxide><Impairment><Industrial Product><Infant><Intermediary Metabolism><Intestinal><Intestines><Life><Life Style><Lifestyle><Light><Link><Liver><Liver diseases><Malignant Neoplasms><Malignant Tumor><Mammary Gland Milk><Mediating><Mediator><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolic dysfunction><Metabolism><Metagenomics><Mice><Mice Mammals><Microbe><Microbial Biofilms><Microbiology><Modeling><Modern Man><Morphology><Mother's Milk><Murine><Mus><Mutation><Outcome><PFAS><Phenotype><Photoradiation><Physiological Homeostasis><Physiology><Poly-fluoroalkyl substances><Predisposition><RNA Expression><Research><Risk Assessment><Role><Safety><Shapes><Streptococcus enterococcus group><Structure><Susceptibility><Technology><Testing><Therapeutic><Thesaurismosis><Tissues><Toxic Environmental Agents><Toxic Environmental Substances><Toxic effect><Toxicant exposure><Toxicities><Toxicokinetics><Toxicology><Transcription><Vancomycin resistant enterococcus><Vancomycin-resistant enterococci><Virulence><Water><Xenobiotics><adulthood><ages><bacteria in the gut><bioaccumulation><biofilm><bowel><chemical property><consumer product><developmental><dietary><diets><digestive tract microbiome><disease model><disorder model><driving><drug resistant><early life exposure><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><environmental chemical><environmental contaminant><environmental risk><environmental toxicant><exposed human population><fecal microbial community><fecal microbiota><full genome><functional adaptation><gastrointestinal microbial flora><gastrointestinal microbiome><genome mutation><genome sequencing><gut bacteria><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hepatic body system><hepatic disease><hepatic organ system><hepatopathy><high throughput screening><host microbe association><host microbe relationship><host microbiome><host-microbe interactions><host-microbial interactions><host-microorganism interactions><human exposure><insight><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kids><later in life><later life><liver disorder><malignancy><maternal milk><metabolism disorder><metabolism measurement><metabolomics><metabonomics><microbial><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota composition><mouse model><murine model><neoplasm/cancer><novel><opportunistic pathogen><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><physical property><polyfluorinated alkyl substances><polyfluoroalkyl substances><resilience><resilient><resistance to Drug><resistant to Drug><response><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><toxic exposure><trait><vancomycin resistance enterococci><vancomycin resistance in enterococci><whole genome><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jeffrey M Peters

PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$2,864,424
FY 2026

Project Title

Environmental PFAS alter microbial function, impair host metabolism, and drive disease progression

Grant Number:

1R01ES038206-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/4/2026

End Date:

4/3/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants known for their widespread use and adverse effects on human health (e.g., metabolic disease, cancer). Early-life exposure to PFAS is of particular concern as developmental periods are a critical window of vul...

Research Terms

<0-11 years old><21+ years old><Address><Adult><Adult Human><Adverse effects><Affect><Age><Automobile Driving><Autoregulation><Biometrics><Biometry><Biostatistics><Body Tissues><Breast Milk><Breastmilk><Cancers><Cell Body><Cells><Chemical Exposure><Chemicals><Child><Child Youth><Children (0-21)><Chronic><Communities><Contamination in food><DNA mutation><Data><Development><Diet><Disease Progression><Drug resistance><Enterococcus><Environmental Factor><Environmental Pollutants><Environmental Risk Factor><Environmental Toxin><Evolution><Exposure to><Food Contamination><Functional Metagenomics><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Transcription><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Grant><Health><Hepatic Disorder><High Throughput Assay><Homeostasis><Human><Human Milk><Human Mother's Milk><Hydrogen Oxide><Impairment><Industrial Product><Infant><Intermediary Metabolism><Intestinal><Intestines><Life><Life Style><Lifestyle><Light><Link><Liver><Liver diseases><Malignant Neoplasms><Malignant Tumor><Mammary Gland Milk><Mediating><Mediator><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolic dysfunction><Metabolism><Metagenomics><Mice><Mice Mammals><Microbe><Microbial Biofilms><Microbiology><Modeling><Modern Man><Morphology><Mother's Milk><Murine><Mus><Mutation><Outcome><PFAS><Phenotype><Photoradiation><Physiological Homeostasis><Physiology><Poly-fluoroalkyl substances><Predisposition><RNA Expression><Research><Risk Assessment><Role><Safety><Shapes><Streptococcus enterococcus group><Structure><Susceptibility><Technology><Testing><Therapeutic><Thesaurismosis><Tissues><Toxic Environmental Agents><Toxic Environmental Substances><Toxic effect><Toxicant exposure><Toxicities><Toxicokinetics><Toxicology><Transcription><Vancomycin resistant enterococcus><Vancomycin-resistant enterococci><Virulence><Water><Xenobiotics><adulthood><ages><bacteria in the gut><bioaccumulation><biofilm><bowel><chemical property><consumer product><developmental><dietary><diets><digestive tract microbiome><disease model><disorder model><driving><drug resistant><early life exposure><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><environmental chemical><environmental contaminant><environmental risk><environmental toxicant><exposed human population><fecal microbial community><fecal microbiota><full genome><functional adaptation><gastrointestinal microbial flora><gastrointestinal microbiome><genome mutation><genome sequencing><gut bacteria><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hepatic body system><hepatic disease><hepatic organ system><hepatopathy><high throughput screening><host microbe association><host microbe relationship><host microbiome><host-microbe interactions><host-microbial interactions><host-microorganism interactions><human exposure><insight><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kids><later in life><later life><liver disorder><malignancy><maternal milk><metabolism disorder><metabolism measurement><metabolomics><metabonomics><microbial><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota composition><mouse model><murine model><neoplasm/cancer><novel><opportunistic pathogen><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><physical property><polyfluorinated alkyl substances><polyfluoroalkyl substances><resilience><resilient><resistance to Drug><resistant to Drug><response><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><toxic exposure><trait><vancomycin resistance enterococci><vancomycin resistance in enterococci><whole genome><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Yuan Tian

PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$2,864,424
FY 2026

Project Title

Environmental PFAS alter microbial function, impair host metabolism, and drive disease progression

Grant Number:

1R01ES038206-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/4/2026

End Date:

4/3/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Per- and polyfluoroalkyl substances (PFAS) are persistent environmental pollutants known for their widespread use and adverse effects on human health (e.g., metabolic disease, cancer). Early-life exposure to PFAS is of particular concern as developmental periods are a critical window of vul...

Research Terms

<0-11 years old><21+ years old><Address><Adult><Adult Human><Adverse effects><Affect><Age><Automobile Driving><Autoregulation><Biometrics><Biometry><Biostatistics><Body Tissues><Breast Milk><Breastmilk><Cancers><Cell Body><Cells><Chemical Exposure><Chemicals><Child><Child Youth><Children (0-21)><Chronic><Communities><Contamination in food><DNA mutation><Data><Development><Diet><Disease Progression><Drug resistance><Enterococcus><Environmental Factor><Environmental Pollutants><Environmental Risk Factor><Environmental Toxin><Evolution><Exposure to><Food Contamination><Functional Metagenomics><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Transcription><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Grant><Health><Hepatic Disorder><High Throughput Assay><Homeostasis><Human><Human Milk><Human Mother's Milk><Hydrogen Oxide><Impairment><Industrial Product><Infant><Intermediary Metabolism><Intestinal><Intestines><Life><Life Style><Lifestyle><Light><Link><Liver><Liver diseases><Malignant Neoplasms><Malignant Tumor><Mammary Gland Milk><Mediating><Mediator><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolic dysfunction><Metabolism><Metagenomics><Mice><Mice Mammals><Microbe><Microbial Biofilms><Microbiology><Modeling><Modern Man><Morphology><Mother's Milk><Murine><Mus><Mutation><Outcome><PFAS><Phenotype><Photoradiation><Physiological Homeostasis><Physiology><Poly-fluoroalkyl substances><Predisposition><RNA Expression><Research><Risk Assessment><Role><Safety><Shapes><Streptococcus enterococcus group><Structure><Susceptibility><Technology><Testing><Therapeutic><Thesaurismosis><Tissues><Toxic Environmental Agents><Toxic Environmental Substances><Toxic effect><Toxicant exposure><Toxicities><Toxicokinetics><Toxicology><Transcription><Vancomycin resistant enterococcus><Vancomycin-resistant enterococci><Virulence><Water><Xenobiotics><adulthood><ages><bacteria in the gut><bioaccumulation><biofilm><bowel><chemical property><consumer product><developmental><dietary><diets><digestive tract microbiome><disease model><disorder model><driving><drug resistant><early life exposure><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><environmental chemical><environmental contaminant><environmental risk><environmental toxicant><exposed human population><fecal microbial community><fecal microbiota><full genome><functional adaptation><gastrointestinal microbial flora><gastrointestinal microbiome><genome mutation><genome sequencing><gut bacteria><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hepatic body system><hepatic disease><hepatic organ system><hepatopathy><high throughput screening><host microbe association><host microbe relationship><host microbiome><host-microbe interactions><host-microbial interactions><host-microorganism interactions><human exposure><insight><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kids><later in life><later life><liver disorder><malignancy><maternal milk><metabolism disorder><metabolism measurement><metabolomics><metabonomics><microbial><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota composition><mouse model><murine model><neoplasm/cancer><novel><opportunistic pathogen><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><physical property><polyfluorinated alkyl substances><polyfluoroalkyl substances><resilience><resilient><resistance to Drug><resistant to Drug><response><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><toxic exposure><trait><vancomycin resistance enterococci><vancomycin resistance in enterococci><whole genome><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

RONALD J. ELLIS

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$896,116
FY 2026

Project Title

Effects of Cannabidiol and Tetrahydrocannabinol on the Microbiome, Endocannabinoids and Neuroinflammation in HIV

Grant Number:

5R01DA056058-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY This project will constitute human research characterizing the microbiome and endocannabinoid system (ECS) in people with HIV (PWH) and how they relate to neuroinflammation and blood-brain barrier (BBB) function. Based on exciting new preliminary findings described here, we propose that alt...

Research Terms

<9-ene-Tetrahydrocannabinol><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Alimentary Canal><Apoptosis><Apoptosis Pathway><Attention><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><BBB function><BBB permeabilization><BBB permeable><Bacteria><Bacteroides><Bifidobacterium><Biological Markers><Blood><Blood - brain barrier anatomy><Blood Reticuloendothelial System><Blood brain barrier dysfunction><Blood monocyte><Blood-Brain Barrier><Body Tissues><Butyrates><CB2><CB2 Receptor><CB2R><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CNR2><CNR2 gene><Cannabidiol><Cannabinoid Receptor CB2><Cannabinoids><Cannabis><Cellular Immunology><Cerebrospinal Fluid><Chronic><Clinical><Clinical Investigator><Clinical Trials><Conduct Clinical Trials><Controlled Clinical Trials><D9-tetrahydrocannabinol><Data><Delta-9-Tetrahydrocannabinol><Digestive Tract><Disease><Disorder><Disseminated Sclerosis><Dronabinol><Drugs><Dysfunction><Endocannabinoids><Endogenous Cannabinoids><Epidiolex><Epithelial Cell Proliferation><Epithelium><Exposure to><Formulation><Functional disorder><GI Tract><GI microbiome><GI microbiota><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Goals><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><HIV><HIV individuals><HIV infected individuals><HIV infected persons><HIV infection persistence><HIV people><HIV persistence><HIV positive individuals><HIV positive people><HIV viral persistence><HIV-1 persistence><Hemato-Encephalic Barrier><Human><Human Immunodeficiency Viruses><Immunologist><Impairment><Inflammation><Inflammation Mediators><Inflammatory><Intervention Studies><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal Leakage><Intestinal permeability><Investigators><LAV-HTLV-III><Large Intestine><Leaky Gut><Ligands><Link><Literature><Lymphadenopathy-Associated Virus><Lymphatic Tissue><Lymphatic cell><Lymphocyte><Lymphocytic><Lymphoid Tissue><Marrow monocyte><Measures><Mediating><Mediation><Mediator><Medication><Modeling><Modern Man><Multiple Sclerosis><Negotiating><Negotiation><Neurologist><Neuropathogenesis><Occluding Junctions><Oral><Oral Administration><Oral Drug Administration><Outcome><Outcome Measure><PLWH><PWH><Pathway interactions><Pattern><Permeability><Persons><Pharmaceutical Preparations><Physiopathology><Predisposition><Prevotella><Production><Programmed Cell Death><Publishing><Randomized><Research><Research Personnel><Researchers><Susceptibility><Syndrome><System><T-Cell Depletion><T-Cells><T-Lymphocyte><T-cell depletion therapy><T-lymphocyte depletion therapy><T4 Cells><T4 Lymphocytes><THC co-use><THC use><Tetrahydrocannabinol><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Therapeutic><Tight Junctions><Tissues><Viral><Virus-HIV><Work><Zonula Occludens><alimentary tract><antiretroviral therapy><antiretroviral treatment><authority><bio-markers><biologic marker><biomarker><blood-brain barrier function><blood-brain barrier permeabilization><blood-brain barrier permeable><bloodbrain barrier><bloodbrain barrier function><bloodbrain barrier permeabilization><bloodbrain barrier permeable><bowel inflammation><cannabinoid receptor><cannabinoid receptor 2><cannabinoid receptor type 2><cannabis use><cerebral spinal fluid><delta(1)-THC><delta(1)-Tetrahydrocannabinol><delta(9)-THC><delta(9)-Tetrahydrocannabinol><determine efficacy><digestive canal><digestive tract microbiome><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><eCB system><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><endocannabinoid system><endogenous cannabinoid system><enteric microbial community><enteric microbiome><enteric microbiota><evaluate efficacy><examine efficacy><exogenous cannabinoid><experience><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut dysbiosis><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><human immunodeficiency virus persistence><improved><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><inflamed bowel><inflamed gut><inflamed intestine><inflammatory mediator><insular sclerosis><intervention research><interventional research><interventional study><interventions research><intestinal biome><intestinal flora><intestinal inflammation><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intraoral drug delivery><large bowel><lymph cell><marijuana use><measurable outcome><metagenome sequencing><metagenomic sequencing><microbial><microbial antigen><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiota><microflora><microorganism antigen><monocyte><multispecies consortia><neural inflammation><neuroinflammation><neuroinflammatory><outcome measurement><pathophysiology><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><persistent HIV><persistent HIV-1><persistent human immunodeficiency virus><phytocannabinoid><pre-clinical study><preclinical study><randomisation><randomization><randomly assigned><remediation><repair><repaired><response><spinal fluid><thymus derived lymphocyte><Δ(1)-THC><Δ(1)-tetrahydrocannabinol><Δ(9)-THC><Δ(9)-tetrahydrocannabinol><Δ-9-tetrahydrocannabinol><Δ9-tetrahydrocannabinol>
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Dong Wang

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$865,792
FY 2026

Project Title

Towards Precision Nutrition for Alzheimer's Dementia Prevention: A Prospective Study of Dietary Patterns, the Gut Microbiome and Cognitive Function

Grant Number:

5R01AG077489-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This proposal directly addresses a high-priority research topic, “Enabling precision medicine for Alzheimer’s disease and related dementias through deep molecular phenotyping”, for PAR-19-070, Research on Current Topics in Alzheimer's Disease and Its Related Dementias, by beginning ...

Research Terms

<2-Phenyl-Benzopyrans><2-Phenyl-Chromenes><21+ years old><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><A β-42><A β42><A-beta 42><A-beta42><AD and related dementia><AD dementia><AD prevention><AD related dementia><AD risk><AD risk factor><ADRD><Abeta-42><Abeta42><Acids><Active Follow-up><Address><Adherence><Adult><Adult Human><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease prevention><Alzheimer prevention><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Aminalon><Aminalone><Amines><Amyloid><Amyloid Substance><Amyloid beta-42><Amyloid beta42><Amyloid β-42><Amyloid β42><Amyloidβ-42><Amyloidβ42><Animal Model><Animal Models and Related Studies><Astroprotein><Aβ-42><Aβ42><BBB permeabilization><BBB permeable><BDNF><Bifidobacterium><Bile Acids><Bioinformatics><Biological Markers><Biometrics><Biometry><Biostatistics><Blood Plasma><Brain-Derived Neurotrophic Factor><Branched-Chain Amino Acids><Butyrates><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cohort Studies><Data><Dementia><Deoxycholic Acid><Desoxycholic Acid><Diet><Dietary Assessment><Dietary Intervention><Dietary Practices><Dihydroxycholanoic Acid><Disturbance in cognition><Enzyme Gene><Enzymes><Epidemiology><Flavonoids><Functional Metagenomics><GABA><GFA-Protein><GFAP><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Transcription><General Taxonomy><Genetic Transcription><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Health><Human><Human Microbiome><Impaired cognition><Individual><Individual Differences><Intermediary Metabolism><Intervention><Knowledge><Kynurenine><Lactobacillus><Light><Link><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Mediating><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mediterranean Diet><Metabolic><Metabolic Processes><Metabolism><Metagenomics><Microbial Taxonomy><Modern Man><Molecular><NMR Imaging><NMR Tomography><Nerve Degeneration><Nerve Transmitter Substances><Neurology><Neuron Degeneration><Neurotransmitters><Nuclear Magnetic Resonance Imaging><Nurses' Health Study><Nutrition><Nutrition Interventions><Nutritional Interventions><Outcome Assessment><Oxides><Participant><Peptides><Personalized medical approach><Photoradiation><Plasma><Plasma Serum><Population><Position><Positioning Attribute><Prevention><Primary Senile Degenerative Dementia><Production><Prospective Studies><RNA Expression><Randomization trial><Randomized><Reporting><Reproducibility><Research><Research Design><Research Priority><Research Resources><Resolution><Resources><Reticuloendothelial System, Serum, Plasma><Risk><Role><Short-Chain Fatty Acids><Shotguns><Study Type><Taxonomy><Technology><Time><Transcription><Volatile Fatty Acids><Zeugmatography><abeta accumulation><abeta aggregation><above age 65><active followup><adjudication><adjudicative process and procedure><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><alzheimer risk><amine><amyloid beta accumulation><amyloid beta aggregation><amyloid β accumulation><amyloid β aggregation><aβ accumulation><aβ aggregation><bio-markers><biologic marker><biomarker><blood-brain barrier permeabilization><blood-brain barrier permeable><bloodbrain barrier permeabilization><bloodbrain barrier permeable><brain MR imaging><brain MRI><brain magnetic resonance imaging><branched amino acids><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><cognitive dysfunction><cognitive function><cognitive loss><cohort research study><cohort survey><cost efficient><design><designing><diet intervention><dietary><dietary approach><dietary pattern><diets><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><epidemiologic><epidemiological><fecal sample><follow up><follow-up><followed up><followup><gamma-Aminobutyric Acid><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><high risk><human old age (65+)><human-associated microbiome><improved><indexing><individual heterogeneity><individual variability><individual variation><individualized approach><individualized prevention><insight><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><metabolism measurement><metabolomics><metabonomics><metatranscriptomics><microbial><microbial composition><microbiome><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><model of animal><molecular phenotype><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurofilament><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal degeneration><new marker><novel><novel biomarker><novel marker><nutritional approach><over 65 years><personalized approach><personalized prevention><precision approach><precision medicine><precision nutrition><precision prevention><precision-based medicine><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><primary degenerative dementia><prospective research study><prospective survey><randomisation><randomization><randomized trial><randomly assigned><resolutions><response><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><shot gun><social role><stool sample><stool specimen><study design><systemic inflammation><systemic inflammatory response><tailored approach><γ-Aminobutyric Acid><≥65 years>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

DEBORAH Anne DEAN

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$816,421
FY 2026

Project Title

Interplay of heterosexual male-female partner microbiomes, Chlamydia trachomatis and transmission

Grant Number:

1R01AI197356-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/6/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Chlamydia trachomatis (Ct) is the leading cause of bacterial sexually transmitted infections (STI) worldwide. About 128M Ct cases are estimated to occur annually according to the WHO and 1.6M in the US. The Western Pacific Region (WPR) has over 61M of these global infections with a prevalenc...

Research Terms

<AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adolescent and Young Adult><Affect><Age><Anatomic Sites><Anatomic structures><Anatomy><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Assay><Azadose><Azithromycin><Azitrocin><Azythromycin><Bioassay><Biological Assay><Bleeding><C trachomatis><C. trachomatis><Cannot achieve a pregnancy><Caucasian><Caucasian Race><Caucasians><Caucasoid><Caucasoid Race><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Characteristics><Chemotactic Cytokines><Chlamydia trachomatis><Communities><DNA><Data><Data Set><Deoxyribonucleic Acid><Development><Diagnosis><Diagnostic Findings><Difficulty conceiving><Disease><Disorder><Ectopic Pregnancy><Endocervix><Epidemic><Female><Fiji><Future><GU Infection><Gene variant><General Taxonomy><Genitourinary System Infection><Genitourinary infection><Genome><Genomics><Goals><HIV><Hemorrhage><Heterosexuals><High Prevalence><Homologous Chemotactic Cytokines><Human Immunodeficiency Viruses><Immune><Immune response><Immunes><Infection><Infertility><Inflammatory><Inflammatory Response><Intercrines><Knowledge><LAV-HTLV-III><Life><Lymphadenopathy-Associated Virus><MSM><Machine Learning><Macrolide antibiotic-resistance><Macrolide-resistance><Macrolides><Male Urethra><Male urethral structure><Man who have sex with Man><Medical><Metabolic Pathway><Metadata><Miscellaneous Antibiotic><Modeling><Multiple Partners><Occidental><Pacific Island individual><Pacific Island population><Pacific Islander><Pathogenesis><Pathogenicity><Pelvic Inflammatory Disease><Phylogeny><Population><Premature Birth><Prematurely delivering><Preterm Birth><Prevalence><Prevention><Preventive><Proctitis><Proteins><Recombinants><Recommendation><Rectal infection><Rectum><Research><Research Resources><Resistance to antibiotics><Resistant to antibiotics><Resources><Rickettsia trachomae><Risk><SIS cytokines><STD prevention><STI prevention><Sampling><Sentinel><Sexually Transmitted Diseases><Sexually Transmitted Disorder><Sexually Transmitted Infection><Shotgun Sequencing><Signs and Symptoms><Single Base Polymorphism><Single Nucleotide Polymorphism><Site><Taxonomy><Testing><Therapeutic><Translating><Transmission><Treatment Protocols><Treatment Regimen><Treatment Schedule><Ultreon><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Urethra><Vagina><Venereal Diseases><Venereal Disorders><Venereal Infections><Virus-HIV><Vulnerable Populations><Woman><Zithromax><Zitromax><ages><allelic variant><anal microbiome><anally infected><annual screening><antibiotic drug resistance><antibiotic resistant><azithromycin resistance><azithromycin resistant><bacteria pathogen><bacterial pathogen><blood loss><chemoattractant cytokine><chemokine><chronic pelvic floor pain><chronic pelvic pain><chronic pelvic pain syndrome><cohort><cytokine><design><designing><developmental><entire genome><extrauterine pregnancy><fertility cessation><fertility loss><fitness><full genome><genetic variant><genome sequencing><genomic variant><high risk><host response><immune system response><immunoresponse><infection risk><infectious disease of genitourinary system><infertile><innovate><innovation><innovative><machine based learning><macrolide resistant><male><men><men having sex with men><men who have sex with men><men who have sex with other men><meta data><metagenome><microbial><microbial consortia><microbial flora><microbiome><microbiota><microflora><multispecies consortia><new diagnostics><next generation diagnostics><novel diagnostics><pathogenic bacteria><pelvic inflammation disease><pelvic inflammation disorder><pelvic inflammatory disorder><pelvic inflammatory syndrome><pelvic myofascial pain><penile urethra><premature childbirth><premature delivery><preterm delivery><prevent STI><prevent sexually transmitted disease><prevent sexually transmitted infections><protect against STI><protect against sexually transmitted disease><protect against sexually transmitted infection><protect from STI><protect from sexually transmitted infection><rectal microbiome><rectally infected><rectitis><rectum inflammation><rectum microbiome><resistance gene><resistance locus><resistance mutation><resistance to macrolide><resistant gene><resistant mutation><resistant to azithromycin><resistant to macrolide><resistome><routine screening><screening><screenings><sex><sexually acquired infection><sexually transmitted disease prevention><sexually transmitted infection prevention><single nucleotide variant><stem><transmission process><tubal factor infertility><tubal infertility><urethral><urethral microbiome><urinary tract microbiome><urogenital infection><vaginal biome><vaginal microbiome><vulnerable group><vulnerable individual><vulnerable people><white race><whole genome><♀><♂>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Timothy D. Read

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$816,421
FY 2026

Project Title

Interplay of heterosexual male-female partner microbiomes, Chlamydia trachomatis and transmission

Grant Number:

1R01AI197356-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/6/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Chlamydia trachomatis (Ct) is the leading cause of bacterial sexually transmitted infections (STI) worldwide. About 128M Ct cases are estimated to occur annually according to the WHO and 1.6M in the US. The Western Pacific Region (WPR) has over 61M of these global infections with a prevalenc...

Research Terms

<AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adolescent and Young Adult><Affect><Age><Anatomic Sites><Anatomic structures><Anatomy><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Assay><Azadose><Azithromycin><Azitrocin><Azythromycin><Bioassay><Biological Assay><Bleeding><C trachomatis><C. trachomatis><Cannot achieve a pregnancy><Caucasian><Caucasian Race><Caucasians><Caucasoid><Caucasoid Race><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Characteristics><Chemotactic Cytokines><Chlamydia trachomatis><Communities><DNA><Data><Data Set><Deoxyribonucleic Acid><Development><Diagnosis><Diagnostic Findings><Difficulty conceiving><Disease><Disorder><Ectopic Pregnancy><Endocervix><Epidemic><Female><Fiji><Future><GU Infection><Gene variant><General Taxonomy><Genitourinary System Infection><Genitourinary infection><Genome><Genomics><Goals><HIV><Hemorrhage><Heterosexuals><High Prevalence><Homologous Chemotactic Cytokines><Human Immunodeficiency Viruses><Immune><Immune response><Immunes><Infection><Infertility><Inflammatory><Inflammatory Response><Intercrines><Knowledge><LAV-HTLV-III><Life><Lymphadenopathy-Associated Virus><MSM><Machine Learning><Macrolide antibiotic-resistance><Macrolide-resistance><Macrolides><Male Urethra><Male urethral structure><Man who have sex with Man><Medical><Metabolic Pathway><Metadata><Miscellaneous Antibiotic><Modeling><Multiple Partners><Occidental><Pacific Island individual><Pacific Island population><Pacific Islander><Pathogenesis><Pathogenicity><Pelvic Inflammatory Disease><Phylogeny><Population><Premature Birth><Prematurely delivering><Preterm Birth><Prevalence><Prevention><Preventive><Proctitis><Proteins><Recombinants><Recommendation><Rectal infection><Rectum><Research><Research Resources><Resistance to antibiotics><Resistant to antibiotics><Resources><Rickettsia trachomae><Risk><SIS cytokines><STD prevention><STI prevention><Sampling><Sentinel><Sexually Transmitted Diseases><Sexually Transmitted Disorder><Sexually Transmitted Infection><Shotgun Sequencing><Signs and Symptoms><Single Base Polymorphism><Single Nucleotide Polymorphism><Site><Taxonomy><Testing><Therapeutic><Translating><Transmission><Treatment Protocols><Treatment Regimen><Treatment Schedule><Ultreon><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Urethra><Vagina><Venereal Diseases><Venereal Disorders><Venereal Infections><Virus-HIV><Vulnerable Populations><Woman><Zithromax><Zitromax><ages><allelic variant><anal microbiome><anally infected><annual screening><antibiotic drug resistance><antibiotic resistant><azithromycin resistance><azithromycin resistant><bacteria pathogen><bacterial pathogen><blood loss><chemoattractant cytokine><chemokine><chronic pelvic floor pain><chronic pelvic pain><chronic pelvic pain syndrome><cohort><cytokine><design><designing><developmental><entire genome><extrauterine pregnancy><fertility cessation><fertility loss><fitness><full genome><genetic variant><genome sequencing><genomic variant><high risk><host response><immune system response><immunoresponse><infection risk><infectious disease of genitourinary system><infertile><innovate><innovation><innovative><machine based learning><macrolide resistant><male><men><men having sex with men><men who have sex with men><men who have sex with other men><meta data><metagenome><microbial><microbial consortia><microbial flora><microbiome><microbiota><microflora><multispecies consortia><new diagnostics><next generation diagnostics><novel diagnostics><pathogenic bacteria><pelvic inflammation disease><pelvic inflammation disorder><pelvic inflammatory disorder><pelvic inflammatory syndrome><pelvic myofascial pain><penile urethra><premature childbirth><premature delivery><preterm delivery><prevent STI><prevent sexually transmitted disease><prevent sexually transmitted infections><protect against STI><protect against sexually transmitted disease><protect against sexually transmitted infection><protect from STI><protect from sexually transmitted infection><rectal microbiome><rectally infected><rectitis><rectum inflammation><rectum microbiome><resistance gene><resistance locus><resistance mutation><resistance to macrolide><resistant gene><resistant mutation><resistant to azithromycin><resistant to macrolide><resistome><routine screening><screening><screenings><sex><sexually acquired infection><sexually transmitted disease prevention><sexually transmitted infection prevention><single nucleotide variant><stem><transmission process><tubal factor infertility><tubal infertility><urethral><urethral microbiome><urinary tract microbiome><urogenital infection><vaginal biome><vaginal microbiome><vulnerable group><vulnerable individual><vulnerable people><white race><whole genome><♀><♂>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Eric C Martens

STANFORD UNIVERSITY, STANFORD, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$787,346
FY 2026

Project Title

Restoring Key Functions to the Industrialized Gut Microbiome

Grant Number:

1R01AT013330-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/13/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY The gut microbiome plays a key role in modulating host metabolism and immune responses. Industrialized populations, like U.S. residents, have gut communities with reduced microbial richness and missing key functions, particularly the degradation of microbiota-accessible carbohydrates (MACs, ...

Research Terms

<21+ years old><AD dementia><Acetates><Acute Disease><Adult><Adult Human><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Archives><Assay><Autoimmune Diseases><Bacteria><Behavior><Bile Acids><Bioassay><Biological Assay><Biology><Butyrates><Carbohydrates><Cardiac Diseases><Cardiac Disorders><Cecum><Characteristics><Chronic Disease><Chronic Illness><Clinical Trials><Colon><Communities><Consumption><Custom><Deterioration><Diabetes Mellitus><Diet><Dietary Component><Dietary Fiber><Dietary Intervention><Disease><Disorder><Engraftment><Fermentation><Fiber><Food><Future><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GI microbiome><GI microbiota><GPCR><Gastrointestinal microbiota><Generalized Growth><Genetic><Gnotobiotic><Gnotobiotics><Goals><Growth><GvHD><H element><Health><Health Promotion><Heart Diseases><Homologous Wasting Disease><Human><Hydrogen><Immune><Immune response><Immunes><In Vitro><Individual><Industrialization><Inflammation><Inflammatory><Intermediary Metabolism><Intervention><Intervention Studies><Knowledge><Libraries><Life Style><Lifestyle><Link><Martens><Martes><Measures><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Pathway><Metabolic Processes><Metabolic syndrome><Metabolism><Mice><Mice Mammals><Microbe><Minority><Modeling><Modern Man><Modification><Murine><Mus><Nutrition Interventions><Nutritional Interventions><Outcome><Output><Participant><Pathway interactions><Persons><Play><Population><Pre-Clinical Model><Preclinical Models><Prevalence><Primary Senile Degenerative Dementia><Production><Propionates><Protocol><Protocols documentation><Recovery><Regulation><Runt Disease><Salutogenesis><Short-Chain Fatty Acids><Societies><Solubility><Testing><Thesaurismosis><Tissue Growth><United States><Volatile Fatty Acids><acute disease/disorder><acute disorder><adulthood><alter microbiome><analyze microbiome><autoimmune condition><autoimmune disorder><autoimmunity disease><chronic disorder><chronic inflammatory disease><community microbes><customs><depository><design><designing><diabetes><diet intervention><dietary><diets><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><fecal sample><functional loss><gastrointestinal microbial flora><gastrointestinal microbiome><graft versus host disease><graft vs host disease><graft vs. host disease><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heart disorder><host response><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiota><humanized mice><humanized mouse><immune system response><immunological status><immunoresponse><improved><in vivo Model><inflammation marker><inflammatory marker><intervention research><interventional research><interventional study><interventions research><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><metabolism disorder><metabolism measurement><metabolomics><metabonomics><metagenome sequencing><metagenomic sequencing><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial genomics><microbiome><microbiome adaptation><microbiome alteration><microbiome analysis><microbiome perturbation><microbiota><microflora><microorganism community><mouse model><multispecies consortia><murine model><novel><ontogeny><pathway><polymicrobial community><primary degenerative dementia><promoting health><repair><repaired><repository><response><senile dementia of the Alzheimer type><stool sample><stool specimen><trial readiness>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JUSTIN L SONNENBURG

STANFORD UNIVERSITY, STANFORD, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$787,346
FY 2026

Project Title

Restoring Key Functions to the Industrialized Gut Microbiome

Grant Number:

1R01AT013330-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/13/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY The gut microbiome plays a key role in modulating host metabolism and immune responses. Industrialized populations, like U.S. residents, have gut communities with reduced microbial richness and missing key functions, particularly the degradation of microbiota-accessible carbohydrates (MACs, ...

Research Terms

<21+ years old><AD dementia><Acetates><Acute Disease><Adult><Adult Human><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Archives><Assay><Autoimmune Diseases><Bacteria><Behavior><Bile Acids><Bioassay><Biological Assay><Biology><Butyrates><Carbohydrates><Cardiac Diseases><Cardiac Disorders><Cecum><Characteristics><Chronic Disease><Chronic Illness><Clinical Trials><Colon><Communities><Consumption><Custom><Deterioration><Diabetes Mellitus><Diet><Dietary Component><Dietary Fiber><Dietary Intervention><Disease><Disorder><Engraftment><Fermentation><Fiber><Food><Future><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GI microbiome><GI microbiota><GPCR><Gastrointestinal microbiota><Generalized Growth><Genetic><Gnotobiotic><Gnotobiotics><Goals><Growth><GvHD><H element><Health><Health Promotion><Heart Diseases><Homologous Wasting Disease><Human><Hydrogen><Immune><Immune response><Immunes><In Vitro><Individual><Industrialization><Inflammation><Inflammatory><Intermediary Metabolism><Intervention><Intervention Studies><Knowledge><Libraries><Life Style><Lifestyle><Link><Martens><Martes><Measures><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Pathway><Metabolic Processes><Metabolic syndrome><Metabolism><Mice><Mice Mammals><Microbe><Minority><Modeling><Modern Man><Modification><Murine><Mus><Nutrition Interventions><Nutritional Interventions><Outcome><Output><Participant><Pathway interactions><Persons><Play><Population><Pre-Clinical Model><Preclinical Models><Prevalence><Primary Senile Degenerative Dementia><Production><Propionates><Protocol><Protocols documentation><Recovery><Regulation><Runt Disease><Salutogenesis><Short-Chain Fatty Acids><Societies><Solubility><Testing><Thesaurismosis><Tissue Growth><United States><Volatile Fatty Acids><acute disease/disorder><acute disorder><adulthood><alter microbiome><analyze microbiome><autoimmune condition><autoimmune disorder><autoimmunity disease><chronic disorder><chronic inflammatory disease><community microbes><customs><depository><design><designing><diabetes><diet intervention><dietary><diets><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><fecal sample><functional loss><gastrointestinal microbial flora><gastrointestinal microbiome><graft versus host disease><graft vs host disease><graft vs. host disease><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heart disorder><host response><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiota><humanized mice><humanized mouse><immune system response><immunological status><immunoresponse><improved><in vivo Model><inflammation marker><inflammatory marker><intervention research><interventional research><interventional study><interventions research><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><metabolism disorder><metabolism measurement><metabolomics><metabonomics><metagenome sequencing><metagenomic sequencing><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial genomics><microbiome><microbiome adaptation><microbiome alteration><microbiome analysis><microbiome perturbation><microbiota><microflora><microorganism community><mouse model><multispecies consortia><murine model><novel><ontogeny><pathway><polymicrobial community><primary degenerative dementia><promoting health><repair><repaired><repository><response><senile dementia of the Alzheimer type><stool sample><stool specimen><trial readiness>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

ERIK R DUBBERKE

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$767,314
FY 2026

Project Title

High-resolution genomic interrogation of pathogen-microbiome interactions in Clostridioides difficile infection

Grant Number:

5R01AI184858-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/22/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Clostridioides difficile (Cd) infection (CDI) is a leading cause of healthcare-associated infections in the U.S., affecting ~500,000 people and costing ~$5.4B annually. Despite substantial advances in investigating Cd pathogenesis and transmission over the past 20 years, CDI remains a signi...

Research Terms

<Address><Affect><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Architecture><Atlases><Bacterial Model><Bacteriophages><Biological><Biological Markers><C diff><C difficile><C. diff><C. difficile><C. difficile colitis><Causality><Clinic><Clinical><Clostridioides difficile><Clostridioides difficile colitis><Clostridium difficile><Clostridium difficile colitis><Collection><Communicable Diseases><Community Networks><Complex><Computational toolkit><Development><Diagnosis><Diagnostic><Disease><Disease Outcome><Disease Progression><Disorder><Elements><Engineering / Architecture><Environmental Exposure><Etiology><Feces><Functional Metagenomics><GI commensal><GI microbiome><Gene Transcription><General Taxonomy><Genetic Diversity><Genetic Transcription><Genetic Variation><Genome><Genomics><Gnotobiotic><Gnotobiotics><Goals><Hospitals><Host Factor><Host Factor Protein><Human><Individual><Infection><Infectious Diseases><Infectious Disorder><Integration Host Factors><Investigation><Jewish><Jews><Knowledge><Lead><Mediating><Metadata><Metagenomics><Miscellaneous Antibiotic><Modeling><Modern Man><Morbidity><Motivation><Outcome><Pathogenesis><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Persons><Phages><Phylogenetic Analysis><Phylogenetics><Precision therapeutics><Predisposition><Preventive><Probabilistic Models><Probability Models><Pseudomembranous Colitis><Public Health><RNA Expression><Recurrence><Recurrent><Reproducibility><Research><Research Specimen><Resolution><Risk Assessment><Role><Severity of illness><Specimen><Statistical Models><Susceptibility><Taxonomy><Technology><Testing><Therapeutic><Toxin><Transcription><Transmission><Variant><Variation><Virulence><Virulent><Work><alter microbiome><anti-microbial><antimicrobial><bacterial microbiome><bacterial virus><bacteriome><bio-markers><biobank><biologic><biologic marker><biomarker><biorepository><causation><clinical relevance><clinically relevant><cohort><commensal bacteria><commensal bacteria in the gastrointestinal tract><commensal bacteria in the gut><commensal bacteria in the intestine><commensal bacterial species><commensal community><commensal microbiome><commensal species><community microbes><comparative><computational toolbox><computational tools><computational toolset><computer based prediction><computerized tools><cost><deep sequencing><design><designing><developmental><digestive tract microbiome><disease causation><disease severity><enteric commensal><enteric microbiome><entire genome><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><full genome><gastrointestinal commensal><gastrointestinal microbiome><genetic element><genome analysis><genome sequencing><gut commensal><gut microbiome><gut-associated microbiome><health care associated infections><heavy metal Pb><heavy metal lead><host microbiome><improved><in vivo><infection risk><innovate><innovation><innovative><innovative technologies><intestinal biome><intestinal commensal><intestinal microbiome><meta data><metatranscriptomics><microbe community><microbial community><microbial host><microbiome><microbiome adaptation><microbiome alteration><microbiome community composition><microbiome composition><microbiome perturbation><microbiome signature><microbiome species composition><microbiome structure><microorganism community><model of animal><mortality><mouse model><murine model><new diagnostics><next generation diagnostics><novel><novel diagnostics><pan-genome><pangenome><past epidemic><pathobiont><pathogen><pathway><patient oriented outcomes><patient population><polymicrobial community><pre-clinical><precision therapies><precision treatment><preclinical><predictive modeling><prevent><preventing><previous epidemic><prior epidemic><resident commensals><resolutions><social role><statistical linear mixed models><statistical linear models><stem><stool><stool sample><stool specimen><tool><trait><transmission process><viral microbiome><virome><whole genome>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Gautam Dantas

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$767,314
FY 2026

Project Title

High-resolution genomic interrogation of pathogen-microbiome interactions in Clostridioides difficile infection

Grant Number:

5R01AI184858-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/22/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Clostridioides difficile (Cd) infection (CDI) is a leading cause of healthcare-associated infections in the U.S., affecting ~500,000 people and costing ~$5.4B annually. Despite substantial advances in investigating Cd pathogenesis and transmission over the past 20 years, CDI remains a signi...

Research Terms

<Address><Affect><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Architecture><Atlases><Bacterial Model><Bacteriophages><Biological><Biological Markers><C diff><C difficile><C. diff><C. difficile><C. difficile colitis><Causality><Clinic><Clinical><Clostridioides difficile><Clostridioides difficile colitis><Clostridium difficile><Clostridium difficile colitis><Collection><Communicable Diseases><Community Networks><Complex><Computational toolkit><Development><Diagnosis><Diagnostic><Disease><Disease Outcome><Disease Progression><Disorder><Elements><Engineering / Architecture><Environmental Exposure><Etiology><Feces><Functional Metagenomics><GI commensal><GI microbiome><Gene Transcription><General Taxonomy><Genetic Diversity><Genetic Transcription><Genetic Variation><Genome><Genomics><Gnotobiotic><Gnotobiotics><Goals><Hospitals><Host Factor><Host Factor Protein><Human><Individual><Infection><Infectious Diseases><Infectious Disorder><Integration Host Factors><Investigation><Jewish><Jews><Knowledge><Lead><Mediating><Metadata><Metagenomics><Miscellaneous Antibiotic><Modeling><Modern Man><Morbidity><Motivation><Outcome><Pathogenesis><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Persons><Phages><Phylogenetic Analysis><Phylogenetics><Precision therapeutics><Predisposition><Preventive><Probabilistic Models><Probability Models><Pseudomembranous Colitis><Public Health><RNA Expression><Recurrence><Recurrent><Reproducibility><Research><Research Specimen><Resolution><Risk Assessment><Role><Severity of illness><Specimen><Statistical Models><Susceptibility><Taxonomy><Technology><Testing><Therapeutic><Toxin><Transcription><Transmission><Variant><Variation><Virulence><Virulent><Work><alter microbiome><anti-microbial><antimicrobial><bacterial microbiome><bacterial virus><bacteriome><bio-markers><biobank><biologic><biologic marker><biomarker><biorepository><causation><clinical relevance><clinically relevant><cohort><commensal bacteria><commensal bacteria in the gastrointestinal tract><commensal bacteria in the gut><commensal bacteria in the intestine><commensal bacterial species><commensal community><commensal microbiome><commensal species><community microbes><comparative><computational toolbox><computational tools><computational toolset><computer based prediction><computerized tools><cost><deep sequencing><design><designing><developmental><digestive tract microbiome><disease causation><disease severity><enteric commensal><enteric microbiome><entire genome><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><full genome><gastrointestinal commensal><gastrointestinal microbiome><genetic element><genome analysis><genome sequencing><gut commensal><gut microbiome><gut-associated microbiome><health care associated infections><heavy metal Pb><heavy metal lead><host microbiome><improved><in vivo><infection risk><innovate><innovation><innovative><innovative technologies><intestinal biome><intestinal commensal><intestinal microbiome><meta data><metatranscriptomics><microbe community><microbial community><microbial host><microbiome><microbiome adaptation><microbiome alteration><microbiome community composition><microbiome composition><microbiome perturbation><microbiome signature><microbiome species composition><microbiome structure><microorganism community><model of animal><mortality><mouse model><murine model><new diagnostics><next generation diagnostics><novel><novel diagnostics><pan-genome><pangenome><past epidemic><pathobiont><pathogen><pathway><patient oriented outcomes><patient population><polymicrobial community><pre-clinical><precision therapies><precision treatment><preclinical><predictive modeling><prevent><preventing><previous epidemic><prior epidemic><resident commensals><resolutions><social role><statistical linear mixed models><statistical linear models><stem><stool><stool sample><stool specimen><tool><trait><transmission process><viral microbiome><virome><whole genome>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jonathan E Posner

DUKE UNIVERSITY, DURHAM, NC

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$741,700
FY 2026

Project Title

Prenatal maternal obesity and neurodevelopment: The mediating role of the microbiome and metabolome

Grant Number:

5R01MH133313-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Impaired emotion regulation (ER) is a risk factor for a wide range of neuropsychiatric conditions and safeguarding its development could have important implications on mental health. Pre-pregnancy obesity has long been associated with indicators of impaired ER in children – e.g., ele...

Research Terms

<0-11 years old><12 year old><12 years of age><1st trimester><3rd trimester><5-HT><5-Hydroxytryptamine><5HT><AD/HD><ADHD><Address><Affect><Ammon Horn><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anxiety Disorders><Attention deficit hyperactivity disorder><BMI><BMI percentile><BMI z-score><Behavior><Behavioral><Behavioral Assay><Birth><Blood><Blood Reticuloendothelial System><Body mass index><Brain><Brain Nervous System><Central Lobe><Child><Child Nutrition><Child Rearing><Child Youth><Children (0-21)><Clinical><Code><Coding System><Collection><Cornu Ammonis><Cross-Product Ratio><Data><Depressive Syndromes><Depressive disorder><Development><Diffusion><Discipline of obstetrics><Dopamine><Early Placental Phase><Eating Disorders><Emotional><Encephalon><Enrollment><Enteramine><Enzyme Gene><Enzymes><Exposure to><Feces><First Pregnancy Trimester><First Trimester><Functional MRI><Functional Magnetic Resonance Imaging><GI microbiome><Genes><Genetic><Gestation><Health><Hippocampus><Hippophaine><Human><Hydroxytyramine><Impairment><Individual><Individuals from minority><Individuals of minority><Infant><Inflammation><Insula><Insula of Reil><Intermediary Metabolism><Island of Reil><L-Tryptophan><Laboratories><Last Trimester><Levotryptophan><Life><Link><Low income><MR Imaging><MR Tomography><MRI><MRI Scans><MRIs><Magnetic Resonance Imaging><Magnetic Resonance Imaging Scan><Measures><Mediating><Mediation><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medical Records><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Minority Groups><Minority People><Minority Population><Minority individual><Modern Man><Mothers><NMR Imaging><NMR Tomography><Negotiating><Negotiation><Neural Development><Nuclear Magnetic Resonance Imaging><Obesity><Obstetrics><Odds Ratio><Parenting><Parenting behavior><Parturition><Pathway interactions><Perinatal><Peripartum><Position><Positioning Attribute><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prefrontal Cortex><Pregnancy><Pregnancy Trimesters><Pregnant Women><Prevention><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychopathology><Quetelet index><Relative Odds><Research><Rest><Risk><Risk Factors><Risk Ratio><Rodent Model><Role><Sampling><Serotonin><System><Temperament><Testing><Third Pregnancy Trimester><Third Trimester><Time><Tryptophan><Tryptophan Metabolism><Tryptophan Metabolism Pathway><Tyrosine><Tyrosine Metabolism><Tyrosine Metabolism Pathway><Universities><Vertical Transmission><Zeugmatography><abnormal psychology><adiposity><age 12><age 12 years><amygdaloid nuclear complex><birth cohort study><birth cohort survey><brain MR imaging><brain MRI><brain magnetic resonance imaging><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><childrearing><cohort><comparing females and males><comparing women and men><corpulence><depression><design><designing><developmental><diffused><diffuses><diffusing><diffusions><digestive tract microbiome><emotion regulation><emotional regulation><enroll><enteric microbiome><epidemiology research study><epidemiology study><epidemiology survey><expectant mother><expectant women><expecting mother><expecting women><experience><fMRI><females compared to males><females compared with males><females versus males><females vs. males><fetal><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><high risk group><high risk individual><high risk people><high risk population><hippocampal><in utero><individuals who are pregnant><innovate><innovation><innovative><intestinal biome><intestinal microbiome><kids><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><maternal GI tract><maternal adiposity><maternal gut><maternal microbiome><maternal obesity><maternal serum><maternal stress><mental illness><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metagenome><microbial><microbiome><mood symptom><mother's gut><mouse model><multi-modality><multimodality><murine model><neural imaging><neuro-imaging><neurodevelopment><neuroimaging><neurological imaging><neuropsychiatric><neuropsychiatry><offspring><pathway><pediatric nutrition><people who are pregnant><postnatal><pre-clinical><pre-clinical research><preclinical><preclinical research><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prepregnancy><prepregnancy obesity><psychiatric illness><psychological disorder><sex><social role><stool><stressed mothers><those who are pregnant><tractography><twelve year old><twelve years of age><unborn><women compared to men><women compared with men><women versus men><women vs. men><women who are pregnant><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

YUN WANG

DUKE UNIVERSITY, DURHAM, NC

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$741,700
FY 2026

Project Title

Prenatal maternal obesity and neurodevelopment: The mediating role of the microbiome and metabolome

Grant Number:

5R01MH133313-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Impaired emotion regulation (ER) is a risk factor for a wide range of neuropsychiatric conditions and safeguarding its development could have important implications on mental health. Pre-pregnancy obesity has long been associated with indicators of impaired ER in children – e.g., ele...

Research Terms

<0-11 years old><12 year old><12 years of age><1st trimester><3rd trimester><5-HT><5-Hydroxytryptamine><5HT><AD/HD><ADHD><Address><Affect><Ammon Horn><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anxiety Disorders><Attention deficit hyperactivity disorder><BMI><BMI percentile><BMI z-score><Behavior><Behavioral><Behavioral Assay><Birth><Blood><Blood Reticuloendothelial System><Body mass index><Brain><Brain Nervous System><Central Lobe><Child><Child Nutrition><Child Rearing><Child Youth><Children (0-21)><Clinical><Code><Coding System><Collection><Cornu Ammonis><Cross-Product Ratio><Data><Depressive Syndromes><Depressive disorder><Development><Diffusion><Discipline of obstetrics><Dopamine><Early Placental Phase><Eating Disorders><Emotional><Encephalon><Enrollment><Enteramine><Enzyme Gene><Enzymes><Exposure to><Feces><First Pregnancy Trimester><First Trimester><Functional MRI><Functional Magnetic Resonance Imaging><GI microbiome><Genes><Genetic><Gestation><Health><Hippocampus><Hippophaine><Human><Hydroxytyramine><Impairment><Individual><Individuals from minority><Individuals of minority><Infant><Inflammation><Insula><Insula of Reil><Intermediary Metabolism><Island of Reil><L-Tryptophan><Laboratories><Last Trimester><Levotryptophan><Life><Link><Low income><MR Imaging><MR Tomography><MRI><MRI Scans><MRIs><Magnetic Resonance Imaging><Magnetic Resonance Imaging Scan><Measures><Mediating><Mediation><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medical Records><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Minority Groups><Minority People><Minority Population><Minority individual><Modern Man><Mothers><NMR Imaging><NMR Tomography><Negotiating><Negotiation><Neural Development><Nuclear Magnetic Resonance Imaging><Obesity><Obstetrics><Odds Ratio><Parenting><Parenting behavior><Parturition><Pathway interactions><Perinatal><Peripartum><Position><Positioning Attribute><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prefrontal Cortex><Pregnancy><Pregnancy Trimesters><Pregnant Women><Prevention><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychopathology><Quetelet index><Relative Odds><Research><Rest><Risk><Risk Factors><Risk Ratio><Rodent Model><Role><Sampling><Serotonin><System><Temperament><Testing><Third Pregnancy Trimester><Third Trimester><Time><Tryptophan><Tryptophan Metabolism><Tryptophan Metabolism Pathway><Tyrosine><Tyrosine Metabolism><Tyrosine Metabolism Pathway><Universities><Vertical Transmission><Zeugmatography><abnormal psychology><adiposity><age 12><age 12 years><amygdaloid nuclear complex><birth cohort study><birth cohort survey><brain MR imaging><brain MRI><brain magnetic resonance imaging><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><childrearing><cohort><comparing females and males><comparing women and men><corpulence><depression><design><designing><developmental><diffused><diffuses><diffusing><diffusions><digestive tract microbiome><emotion regulation><emotional regulation><enroll><enteric microbiome><epidemiology research study><epidemiology study><epidemiology survey><expectant mother><expectant women><expecting mother><expecting women><experience><fMRI><females compared to males><females compared with males><females versus males><females vs. males><fetal><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><high risk group><high risk individual><high risk people><high risk population><hippocampal><in utero><individuals who are pregnant><innovate><innovation><innovative><intestinal biome><intestinal microbiome><kids><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><maternal GI tract><maternal adiposity><maternal gut><maternal microbiome><maternal obesity><maternal serum><maternal stress><mental illness><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metagenome><microbial><microbiome><mood symptom><mother's gut><mouse model><multi-modality><multimodality><murine model><neural imaging><neuro-imaging><neurodevelopment><neuroimaging><neurological imaging><neuropsychiatric><neuropsychiatry><offspring><pathway><pediatric nutrition><people who are pregnant><postnatal><pre-clinical><pre-clinical research><preclinical><preclinical research><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prepregnancy><prepregnancy obesity><psychiatric illness><psychological disorder><sex><social role><stool><stressed mothers><those who are pregnant><tractography><twelve year old><twelve years of age><unborn><women compared to men><women compared with men><women versus men><women vs. men><women who are pregnant><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

M. FIROZE KHAN

UNIVERSITY OF TEXAS MED BR GALVESTON, GALVESTON, TX

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$718,775
FY 2026

Project Title

Understanding the role of gut microbiome in trichloroethene-mediated autoimmunity

Grant Number:

1R01ES037276-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Trichloroethene (trichloroethylene, TCE), an environmental and occupational agent, is known to cause autoimmune diseases (ADs), including SLE-like disease in humans. The etiology of SLE is multifactorial, which includes genetic, hormonal and environmental triggers. There is increasing evide...

Research Terms

<(TNF)-α><16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Acceleration><Adoptive Transfer><Affect><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antioxidants><Autoimmune Diseases><Autoimmune Responses><Autoimmune Status><Autoimmunity><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Beta Proprotein Interleukin 1><Blood Serum><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CSIF><CSIF-10><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cachectin><Causality><Cecum><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chemicals><Circulation><Colon><Cytokine Synthesis Inhibitory Factor><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Data><Development><Disease><Disease Marker><Disease Outcome><Disease Progression><Disorder><Dysfunction><Endotoxins><Environment><Environmental Factor><Environmental Pollutants><Environmental Risk Factor><Epithelium><Equilibrium><Ethinyl Trichloride><Etiology><Exposure to><FOXP3><FOXP3 gene><Feces><Female><Forkhead Box P3><Functional disorder><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genes><Genetic><Germ-Free><Goals><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><HPGF><Hepatocyte-Stimulating Factor><Histology><Hormonal><Human><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-1 beta><IL-1 β><IL-1-b><IL-10><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL-1β><IL-6><IL1-Beta><IL1-β><IL10><IL10A><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><IL1B Protein><IL1F2><IL1β><IL6 Protein><Immune><Immune system><Immunes><Impairment><Industrialization><Inflammasome><Inflammatory><Inflammatory Response><Interleukin 10 Precursor><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin 1beta><Interleukin-1 beta><Interleukin-10><Interleukin-17><Interleukin-1β><Interleukin-6><Intermediary Metabolism><Intestinal><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Intracellular Communication and Signaling><JM2><Kidney><Kidney Urinary System><Knowledge><Lactobacillus><Leucocytic infiltrate><Life><Link><Lupus Erythematosus Disseminatus><MGI-2><Macrophage-Derived TNF><Mediating><Metabolic><Metabolic Processes><Metabolism><Metals><Mice><Mice Mammals><Miscellaneous Antibiotic><Modern Man><Monocyte-Derived TNF><Morphology><Mucosa><Mucosal Immunity><Mucosal Tissue><Mucous Membrane><Murine><Mus><Myeloid Differentiation-Inducing Protein><Occluding Junctions><Occupational><Organic Solvents><Organic solvent product><Oxidative Stress><Pathogenesis><Pathogenicity><Pathologic><Phenotype><Physiopathology><Plasmacytoma Growth Factor><Play><Population><Predisposition><Preinterleukin 1 Beta><Probiotics><Process><Proteins><Regulatory T-Lymphocyte><Ribosomal RNA><Role><SCURFIN><SLE><Serum><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Source><Supplementation><Susceptibility><Systemic Lupus Erythematosus><Systemic Lupus Erythematous><Systemic Lupus Erythmatosus><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Therapeutic><Tight Junctions><Time><Transmission><Treg><Trichloroethene><Trichloroethylene><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Volatile Fatty Acids><Zonula Occludens><alter microbiome><autoimmune condition><autoimmune disorder><autoimmunity disease><balance><balance function><biological signal transduction><bowel><causation><chronic autoimmune disease><cytokine><design><designing><developmental><digestive tract microbiome><disease causation><disseminated lupus erythematosus><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><environmental contaminant><environmental risk><fatty acid supplementation><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal sample><fecal transplant><fecal transplantation><feeding><full genome><gastrointestinal homeostasis><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut dysbiosis><gut flora><gut homeostasis><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbiome><in vivo><innovate><innovation><innovative><insight><interferon beta 2><intestinal biome><intestinal flora><intestinal homeostasis><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><lupus-like><metagenome sequencing><metagenomic sequencing><microbe pathogen><microbial><microbial consortia><microbial flora><microbial imbalance><microbial pathogen><microbiome><microbiome adaptation><microbiome alteration><microbiome community composition><microbiome composition><microbiome perturbation><microbiome species composition><microbiome structure><microbiota><microflora><multispecies consortia><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathogenic microbe><pathophysiology><prevent><preventing><probiotic therapeutic><probiotic therapy><probiotic treatment><rRNA><regulatory T-cells><renal><social role><stool><stool sample><stool specimen><supplementation with fatty acids><systemic inflammation><systemic inflammatory response><systemic lupus erythematosis><thymus derived lymphocyte><transmission process><trichloro-ethene><whole genome><♀>
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Nicole Baumgarth

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$700,997
FY 2026

Project Title

Immune homeostasis during Borrelia burgdorferi infection

Grant Number:

1R01AI187421-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Infections can have a significant negative impact on a person’s health even long after the pathogen is cleared from the host. Borrelia burgdorferi (Bb) the causative agent of Lyme disease causes persistent, non-resolving infections in laboratory mice. Previous work has identified significant...

Research Terms

<7S Gamma Globulin><Ab response><Abscission><Address><Affect><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Antibodies><Antibody Affinity><Antibody Formation><Antibody Production><Antibody Response><Autoregulation><Aves><Avian><B blood cells><B burgdorferi><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><B. burgdorferi><Bacteria><Bacterial Infections><Birds><Blood Serum><Body Tissues><Borrelia burgdorferi><Borrelia burgdorferi sensu stricto><Borreliella burgdorferi><Cellular Immune Function><Chemicals><Clinical><Clinical Research><Clinical Study><Data><Defect><Development><Disease><Disorder><Dysfunction><Endotoxemia><Excision><Extirpation><Failure><Fatty Acid Metabolism Pathway><Feces><Feedback><Functional disorder><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Generations><Germinal Center><Growth><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><Health><Homeostasis><Human><Humoral Immunities><Hyper-γ-globulinemia><Hypergammaglobulinemia><IgG><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune Evasion><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune Targeting><Immune response><Immune system><Immunes><Immunity><Immunoglobulin G><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Impairment><Individual><Infection><Infection prevention><Inflammation><Interruption><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal Leakage><Intestinal permeability><Laboratory mice><Leaky Gut><Life Cycle><Life Cycle Stages><Long-Term Effects><Long-term infection><Lyme Borreliosis><Lyme Disease><Lyme Disease Spirochete><Macrophage><Mammalia><Mammals><Marketing><Measures><Mediating><Memory><Metabolic><Methods><Mice><Mice Mammals><Miscellaneous Antibiotic><Modern Man><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Mφ><Pathogenesis><Patients><Persons><Physiological Homeostasis><Physiopathology><Prevent infection><Production><Regulation><Removal><Resistance to antibiotics><Resistant to antibiotics><Rodent><Rodentia><Rodents Mammals><Serum><Short-Chain Fatty Acids><Structure of germinal center of lymph node><Surgical Removal><Symptoms><Syndrome><Testing><Therapeutic Intervention><Tissue Growth><Tissues><Vector-borne disease><Vector-borne infectious disease><Vector-transmitted disease><Vector-transmitted infectious disease><Volatile Fatty Acids><Work><adaptive immune response><adaptive immunity><antibiotic drug resistance><antibiotic resistant><antibody biosynthesis><antibody-based immunity><antigen antibody affinity><autoimmune reactivity><autoreactivity><bacteria infection><bacterial disease><bacterial disease treatment><bacterial infectious disease treatment><chronic infection><design><designing><developmental><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><emerging pathogen><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><fatty acid metabolism><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host response><immune evasive><immune function><immune health><immune suppression><immune suppressive activity><immune suppressive function><immune system health><immune system response><immunoglobulin biosynthesis><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><inhibiting antibody><innovate><innovation><innovative><insight><intervention therapy><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><life course><lyme spirochete><metabolome><metabonome><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiota><microflora><mouse model><multispecies consortia><murine model><new pathogen><novel pathogen><ontogeny><pathogen><pathophysiology><persistent infection><prevent><preventing><resection><response><stool><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic development><tick mediated transmission><tick population><tick transmission><tick transmitted><vector-borne illness><vectorborne disease><vectorborne illness><vectorborne infectious disease>
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Sarah Anne Tishkoff

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$688,506
FY 2026

Project Title

Integrative Genomic Analyses of Human Evolution and Complex Traits in Africa

Grant Number:

1R35GM161902-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Africa is the site of origin of modern humans, contains the greatest levels of human genomic variation, and is the source of the worldwide range expansion of modern humans in the past 100,000 years. However, a fundamental gap in knowledge exists regarding African genomic and phenotypic variation, re...

Research Terms

<Africa><African><Assay><Bioassay><Biologic Models><Biological Assay><Biological Models><Biomedical Research><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Line><CellLine><Cells><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Communities><Complex><Data><Diet><Evolution><GI microbiome><GWA study><GWAS><Gene Expression><Gene x Environment Interaction><Genetic><Genomic approach><Genomics><Geography><GxE interaction><History><Human><Immune><Immunes><In Vitro><Knowledge><Linkage Disequilibrium><Luciferase Immunologic><Luciferases><Model System><Modern Man><Modernization><Pattern><Phenotype><Population><Proteome><Proteomics><Recording of previous events><Reporter><Role><Site><Source><Strains Cell Lines><Structure><Variant><Variation><assess effectiveness><biomedical resource><cardiometabolic><cardiometabolism><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cultured cell line><determine effectiveness><diets><digestive tract microbiome><disease risk><disorder risk><effectiveness assessment><effectiveness evaluation><enteric microbiome><environment effect on gene><epigenomics><evaluate effectiveness><examine effectiveness><functional genomics><gastrointestinal microbiome><gene environment interaction><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic effort><genomic strategy><genomic variation><gut microbiome><gut-associated microbiome><histories><in vivo><in vivo Model><intestinal biome><intestinal microbiome><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbiome><phenotypic data><polygenetic risk scores><polygenic risk score><social role><trait><transcriptomics><whole genome association analysis><whole genome association study>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Michael Edwin Boulton

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$668,581
FY 2026

Project Title

Bacterial Derived Metabolites in Diabetic Retinopathy

Grant Number:

1R01EY038525-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

We are at a watershed moment in human biology were we have identified that we have an axillary microbial genome that affects how our cells function and we can leverage this genome to tackle complex diseases such as diabetic retinopathy (DR). Thus, the human host is inextricably linked to its microbi...

Research Terms

<(TNF)-α><Acids><Adherens Junction><Adhering Junction><Adhesive Junction><Adult-Onset Diabetes Mellitus><Affect><Age><Age related macular degeneration><Age-Related Maculopathy><Anchoring Junction><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Armpit><Assay><Autoregulation><Axilla><Axillary><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Background Diabetic Retinopathy><Bacteria><Bile Acids><Bioassay><Biological Assay><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood capillaries><Blood-Retinal Barrier><Body Tissues><Cachectin><Cell Body><Cell Communication and Signaling><Cell Function><Cell Locomotion><Cell Migration><Cell Movement><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Immune Function><Cellular Migration><Cellular Motility><Cellular Physiology><Cellular Process><Circulation><Communication><Complex><D-Glucose><Data><Development><Dextrans><Dextrose><Diabetes Mellitus><Diabetic Retinopathy><Diabetic mouse><Digestion><Dipeptides><Disease><Disorder><Dose><Dysfunction><Eating><Endothelial Cells><Endothelium><Energy Expenditure><Energy Metabolism><Enzyme Gene><Enzymes><Epithelial Cells><Epithelium><Extravasation><Eye><Eye diseases><Eyeball><Fat-Restricted Diet><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Food Intake><Functional disorder><GI microbiome><Gene Modified><Generations><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genome><Glaucoma><Glucose><HPGF><Health><Hepatocyte-Stimulating Factor><High Fat Diet><Homeostasis><Human><Human Biology><Human Microbiome><Hybridoma Growth Factor><Hyperglycemia><Hypertension><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immune><Immune response><Immunes><In Vitro><Individual><Indoles><Inflammation><Inflammatory><Inner Nuclear Layer><Interleukin-6><Intermediary Metabolism><Intervention><Intestinal><Intestines><Intracellular Communication and Signaling><Ketosis-Resistant Diabetes Mellitus><Kinetics><Knock-out><Knockout><L-Tryptophan><LC/MS><Leakage><Levotryptophan><Link><Lipids><Lipopolysaccharides><Low-Fat Diet><MGI-2><Macrophage-Derived TNF><Maturity-Onset Diabetes Mellitus><Measurement><Measures><Mediating><Metabolic Processes><Metabolism><Mice><Mice Mammals><Modeling><Modern Man><Monocyte-Derived TNF><Murine><Mus><Myeloid Differentiation-Inducing Protein><NIDDM><Neural Retina><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Non-Proliferative Diabetic Retinopathy><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nuclear Receptors><Nutraceutical><Occluding Junctions><Oral Administration><Oral Drug Administration><Organ><Outer pigmented layer of retina><Outsourcing><PXR receptor><Pathology><Physiological Homeostasis><Physiopathology><Pigment Epithelium><Pigment cell layer of retina><Pigmented layer of retina><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Probiotics><Production><Proteins><Publishing><Receptor Protein><Recombinant DNA Technology><Reticuloendothelial System, Serum, Plasma><Retina><Retina Proper><Retinal Artery Occlusion><Retinal Diseases><Retinal Disorder><Retinal Pigment Epithelium><Retinal pigment epithelial cells><STZ><Serous><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Spillage><Stable Diabetes Mellitus><Streptozocin><Streptozotocin><Structure><Structure of retinal pigment epithelium><Subcellular Process><Sulfate><Supplementation><System><T2 DM><T2D><T2DM><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Tight Junctions><Tissues><Tryptophan><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Underarm><Uveitis><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Virus><Volatile Fatty Acids><Xenobiotics><Zanosar><Zonula Occludens><absorption><adult onset diabetes><age dependent macular degeneration><age induced macular degeneration><age related macular disease><age related macular dystrophy><ages><beneficial flora><beneficial microbes><beneficial microflora><beneficial microorganism><biological signal transduction><bowel><capillary><cell motility><cohort><cytokine><db/db mouse><developmental><dextran><diabetes><diabetes mouse model><diabetic><digestive tract microbiome><disease model><disorder model><enteric microbiome><exposed human population><eye disorder><flow cytophotometry><fungus><gastrointestinal microbiome><gene modification><genetically engineered><genetically modified><glaucomatous><gut health><gut microbes><gut microbial species><gut microbiome><gut-associated microbiome><high blood pressure><host response><human exposure><human-associated microbiome><hyperglycemic><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immune function><immune system response><immunoresponse><improved><in vivo><interferon beta 2><intestinal biome><intestinal epithelium><intestinal microbes><intestinal microbiome><intraoral drug delivery><ketosis resistant diabetes><liquid chromatography mass spectrometry><macrovascular complication><macrovascular disease><maturity onset diabetes><metabolism measurement><metabolomics><metabonomics><microbes genome><microbial><microbial consortia><microbial flora><microbial genome><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microbiota derived metabolites><microbiota metabolites><microflora><mouse model><multispecies consortia><murine model><new approaches><novel approaches><novel strategies><novel strategy><ocular disease><ocular disorder><ophthalmopathy><overexpress><overexpression><oxidative damage><oxidative injury><particle><pathophysiology><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pregnane X receptor><prevent><preventing><receptor><receptor expression><retina disease><retina disorder><retina outer nuclear layer><retinopathy><senile macular disease><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><type 2 DM><type II DM><type two diabetes>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Maria Bartolomeo Grant

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$668,581
FY 2026

Project Title

Bacterial Derived Metabolites in Diabetic Retinopathy

Grant Number:

1R01EY038525-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

We are at a watershed moment in human biology were we have identified that we have an axillary microbial genome that affects how our cells function and we can leverage this genome to tackle complex diseases such as diabetic retinopathy (DR). Thus, the human host is inextricably linked to its microbi...

Research Terms

<(TNF)-α><Acids><Adherens Junction><Adhering Junction><Adhesive Junction><Adult-Onset Diabetes Mellitus><Affect><Age><Age related macular degeneration><Age-Related Maculopathy><Anchoring Junction><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Armpit><Assay><Autoregulation><Axilla><Axillary><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Background Diabetic Retinopathy><Bacteria><Bile Acids><Bioassay><Biological Assay><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood capillaries><Blood-Retinal Barrier><Body Tissues><Cachectin><Cell Body><Cell Communication and Signaling><Cell Function><Cell Locomotion><Cell Migration><Cell Movement><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Immune Function><Cellular Migration><Cellular Motility><Cellular Physiology><Cellular Process><Circulation><Communication><Complex><D-Glucose><Data><Development><Dextrans><Dextrose><Diabetes Mellitus><Diabetic Retinopathy><Diabetic mouse><Digestion><Dipeptides><Disease><Disorder><Dose><Dysfunction><Eating><Endothelial Cells><Endothelium><Energy Expenditure><Energy Metabolism><Enzyme Gene><Enzymes><Epithelial Cells><Epithelium><Extravasation><Eye><Eye diseases><Eyeball><Fat-Restricted Diet><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Food Intake><Functional disorder><GI microbiome><Gene Modified><Generations><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genome><Glaucoma><Glucose><HPGF><Health><Hepatocyte-Stimulating Factor><High Fat Diet><Homeostasis><Human><Human Biology><Human Microbiome><Hybridoma Growth Factor><Hyperglycemia><Hypertension><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immune><Immune response><Immunes><In Vitro><Individual><Indoles><Inflammation><Inflammatory><Inner Nuclear Layer><Interleukin-6><Intermediary Metabolism><Intervention><Intestinal><Intestines><Intracellular Communication and Signaling><Ketosis-Resistant Diabetes Mellitus><Kinetics><Knock-out><Knockout><L-Tryptophan><LC/MS><Leakage><Levotryptophan><Link><Lipids><Lipopolysaccharides><Low-Fat Diet><MGI-2><Macrophage-Derived TNF><Maturity-Onset Diabetes Mellitus><Measurement><Measures><Mediating><Metabolic Processes><Metabolism><Mice><Mice Mammals><Modeling><Modern Man><Monocyte-Derived TNF><Murine><Mus><Myeloid Differentiation-Inducing Protein><NIDDM><Neural Retina><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Non-Proliferative Diabetic Retinopathy><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nuclear Receptors><Nutraceutical><Occluding Junctions><Oral Administration><Oral Drug Administration><Organ><Outer pigmented layer of retina><Outsourcing><PXR receptor><Pathology><Physiological Homeostasis><Physiopathology><Pigment Epithelium><Pigment cell layer of retina><Pigmented layer of retina><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Probiotics><Production><Proteins><Publishing><Receptor Protein><Recombinant DNA Technology><Reticuloendothelial System, Serum, Plasma><Retina><Retina Proper><Retinal Artery Occlusion><Retinal Diseases><Retinal Disorder><Retinal Pigment Epithelium><Retinal pigment epithelial cells><STZ><Serous><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Spillage><Stable Diabetes Mellitus><Streptozocin><Streptozotocin><Structure><Structure of retinal pigment epithelium><Subcellular Process><Sulfate><Supplementation><System><T2 DM><T2D><T2DM><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Tight Junctions><Tissues><Tryptophan><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Underarm><Uveitis><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Virus><Volatile Fatty Acids><Xenobiotics><Zanosar><Zonula Occludens><absorption><adult onset diabetes><age dependent macular degeneration><age induced macular degeneration><age related macular disease><age related macular dystrophy><ages><beneficial flora><beneficial microbes><beneficial microflora><beneficial microorganism><biological signal transduction><bowel><capillary><cell motility><cohort><cytokine><db/db mouse><developmental><dextran><diabetes><diabetes mouse model><diabetic><digestive tract microbiome><disease model><disorder model><enteric microbiome><exposed human population><eye disorder><flow cytophotometry><fungus><gastrointestinal microbiome><gene modification><genetically engineered><genetically modified><glaucomatous><gut health><gut microbes><gut microbial species><gut microbiome><gut-associated microbiome><high blood pressure><host response><human exposure><human-associated microbiome><hyperglycemic><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immune function><immune system response><immunoresponse><improved><in vivo><interferon beta 2><intestinal biome><intestinal epithelium><intestinal microbes><intestinal microbiome><intraoral drug delivery><ketosis resistant diabetes><liquid chromatography mass spectrometry><macrovascular complication><macrovascular disease><maturity onset diabetes><metabolism measurement><metabolomics><metabonomics><microbes genome><microbial><microbial consortia><microbial flora><microbial genome><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microbiota derived metabolites><microbiota metabolites><microflora><mouse model><multispecies consortia><murine model><new approaches><novel approaches><novel strategies><novel strategy><ocular disease><ocular disorder><ophthalmopathy><overexpress><overexpression><oxidative damage><oxidative injury><particle><pathophysiology><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pregnane X receptor><prevent><preventing><receptor><receptor expression><retina disease><retina disorder><retina outer nuclear layer><retinopathy><senile macular disease><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><type 2 DM><type II DM><type two diabetes>
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Qiuhong Li

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$668,581
FY 2026

Project Title

Bacterial Derived Metabolites in Diabetic Retinopathy

Grant Number:

1R01EY038525-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

We are at a watershed moment in human biology were we have identified that we have an axillary microbial genome that affects how our cells function and we can leverage this genome to tackle complex diseases such as diabetic retinopathy (DR). Thus, the human host is inextricably linked to its microbi...

Research Terms

<(TNF)-α><Acids><Adherens Junction><Adhering Junction><Adhesive Junction><Adult-Onset Diabetes Mellitus><Affect><Age><Age related macular degeneration><Age-Related Maculopathy><Anchoring Junction><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Armpit><Assay><Autoregulation><Axilla><Axillary><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Background Diabetic Retinopathy><Bacteria><Bile Acids><Bioassay><Biological Assay><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood capillaries><Blood-Retinal Barrier><Body Tissues><Cachectin><Cell Body><Cell Communication and Signaling><Cell Function><Cell Locomotion><Cell Migration><Cell Movement><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Immune Function><Cellular Migration><Cellular Motility><Cellular Physiology><Cellular Process><Circulation><Communication><Complex><D-Glucose><Data><Development><Dextrans><Dextrose><Diabetes Mellitus><Diabetic Retinopathy><Diabetic mouse><Digestion><Dipeptides><Disease><Disorder><Dose><Dysfunction><Eating><Endothelial Cells><Endothelium><Energy Expenditure><Energy Metabolism><Enzyme Gene><Enzymes><Epithelial Cells><Epithelium><Extravasation><Eye><Eye diseases><Eyeball><Fat-Restricted Diet><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Food Intake><Functional disorder><GI microbiome><Gene Modified><Generations><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genome><Glaucoma><Glucose><HPGF><Health><Hepatocyte-Stimulating Factor><High Fat Diet><Homeostasis><Human><Human Biology><Human Microbiome><Hybridoma Growth Factor><Hyperglycemia><Hypertension><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immune><Immune response><Immunes><In Vitro><Individual><Indoles><Inflammation><Inflammatory><Inner Nuclear Layer><Interleukin-6><Intermediary Metabolism><Intervention><Intestinal><Intestines><Intracellular Communication and Signaling><Ketosis-Resistant Diabetes Mellitus><Kinetics><Knock-out><Knockout><L-Tryptophan><LC/MS><Leakage><Levotryptophan><Link><Lipids><Lipopolysaccharides><Low-Fat Diet><MGI-2><Macrophage-Derived TNF><Maturity-Onset Diabetes Mellitus><Measurement><Measures><Mediating><Metabolic Processes><Metabolism><Mice><Mice Mammals><Modeling><Modern Man><Monocyte-Derived TNF><Murine><Mus><Myeloid Differentiation-Inducing Protein><NIDDM><Neural Retina><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Non-Proliferative Diabetic Retinopathy><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nuclear Receptors><Nutraceutical><Occluding Junctions><Oral Administration><Oral Drug Administration><Organ><Outer pigmented layer of retina><Outsourcing><PXR receptor><Pathology><Physiological Homeostasis><Physiopathology><Pigment Epithelium><Pigment cell layer of retina><Pigmented layer of retina><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Probiotics><Production><Proteins><Publishing><Receptor Protein><Recombinant DNA Technology><Reticuloendothelial System, Serum, Plasma><Retina><Retina Proper><Retinal Artery Occlusion><Retinal Diseases><Retinal Disorder><Retinal Pigment Epithelium><Retinal pigment epithelial cells><STZ><Serous><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Spillage><Stable Diabetes Mellitus><Streptozocin><Streptozotocin><Structure><Structure of retinal pigment epithelium><Subcellular Process><Sulfate><Supplementation><System><T2 DM><T2D><T2DM><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Tight Junctions><Tissues><Tryptophan><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Underarm><Uveitis><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Virus><Volatile Fatty Acids><Xenobiotics><Zanosar><Zonula Occludens><absorption><adult onset diabetes><age dependent macular degeneration><age induced macular degeneration><age related macular disease><age related macular dystrophy><ages><beneficial flora><beneficial microbes><beneficial microflora><beneficial microorganism><biological signal transduction><bowel><capillary><cell motility><cohort><cytokine><db/db mouse><developmental><dextran><diabetes><diabetes mouse model><diabetic><digestive tract microbiome><disease model><disorder model><enteric microbiome><exposed human population><eye disorder><flow cytophotometry><fungus><gastrointestinal microbiome><gene modification><genetically engineered><genetically modified><glaucomatous><gut health><gut microbes><gut microbial species><gut microbiome><gut-associated microbiome><high blood pressure><host response><human exposure><human-associated microbiome><hyperglycemic><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immune function><immune system response><immunoresponse><improved><in vivo><interferon beta 2><intestinal biome><intestinal epithelium><intestinal microbes><intestinal microbiome><intraoral drug delivery><ketosis resistant diabetes><liquid chromatography mass spectrometry><macrovascular complication><macrovascular disease><maturity onset diabetes><metabolism measurement><metabolomics><metabonomics><microbes genome><microbial><microbial consortia><microbial flora><microbial genome><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microbiota derived metabolites><microbiota metabolites><microflora><mouse model><multispecies consortia><murine model><new approaches><novel approaches><novel strategies><novel strategy><ocular disease><ocular disorder><ophthalmopathy><overexpress><overexpression><oxidative damage><oxidative injury><particle><pathophysiology><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pregnane X receptor><prevent><preventing><receptor><receptor expression><retina disease><retina disorder><retina outer nuclear layer><retinopathy><senile macular disease><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><type 2 DM><type II DM><type two diabetes>
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Donghai Liang

EMORY UNIVERSITY, ATLANTA, GA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$658,903
FY 2026

Project Title

The Omics and Mixtures Integration on Traffic exposure and Preterm Birth (OMIT-PTB) Study

Grant Number:

5R01ES035738-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/24/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Exposures to prenatal traffic-related air pollution (TRAP), a primary contributor to urban air pollution, have been linked to adverse birth outcomes including preterm birth (PTB). Notably, African American populations are exposed to high TRAP levels and experience elevated rates of PTB. The mechanis...

Research Terms

<0-11 years old><Address><Affect><African American><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><Air Pollution><Attention><Bioinformatics><Biological><Biological Markers><Biological Monitoring><Birth><C-reactive protein><Cell Communication and Signaling><Cell Signaling><Child><Child Health><Child Youth><Children (0-21)><Clinical><Clinical Treatment><Communities><Complex><DNA Methylation><Data><Detection><Disease><Disorder><Dose><Endogenous Nitrate Vasodilator><Endothelium-Derived Nitric Oxide><Environmental Health><Environmental Health Science><Exhalation><Exhaling><Experimental Models><Exposure Assessment><Exposure to><Future><GI microbiome><Gases><Gestation><Health><Health Benefit><Inflammation><Inflammatory><Intervention Strategies><Intracellular Communication and Signaling><Investigators><Knowledge><Late pregnancy><Link><Maps><Maternal Exposure><Maternal and Child Health><Measurement><Mediating><Metabolic Pathway><Methods><Modality><Modeling><Molecular><Mononitrogen Monoxide><Mothers><Multiomic Data><Nitric Oxide><Nitrogen Monoxide><Nitrogen Protoxide><Outcome><Oxidative Stress><Participant><Parturition><Pathway interactions><Phenotype><Pregnancy><Pregnant Women><Premature Birth><Prematurely delivering><Preterm Birth><Process><Proteins, specific or class, C-reactive><Public Health><Research Personnel><Researchers><Resolution><Respiratory Expiration><Risk><Risk Assessment><Risk Reduction><Role><Sample Size><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Site><Techniques><Time><Toxic effect><Toxicities><Women's cohort><Work><adverse birth outcomes><analyzing longitudinal><bio-informatics tool><bio-markers><bioinformatics tool><biologic><biologic marker><biological signal transduction><biomarker><biomonitoring><clinical intervention><clinical therapy><cohort><cohort in women><cohort on women><cytokine><data integration><digestive tract microbiome><early in pregnancy><early pregnancies><early pregnancy><early stage of pregnancy><endothelial cell derived relaxing factor><enteric microbiome><epigenome><expectant mother><expectant women><expecting mother><expecting women><experience><exposed in utero><exposure analysis><exposure evaluation><exposure measurement><exposure profiling><exposure survey><feature selection><female cohort><fetal exposure><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><improved><in utero exposure><individuals who are pregnant><innovate><innovation><innovative><insight><intestinal biome><intestinal microbiome><intra-uterine environmental exposure><intrauterine environmental exposure><kids><longitudinal analysis><maternal GI tract><maternal gut><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><methylation pattern><microbial><microbiome><mother's gut><multidisciplinary><multiomics><multiple omic data><multiple omics><novel><panomics><particle><pathway><people who are pregnant><pollutant><potential biological marker><potential biomarker><pre-clinical><preclinical><pregnant females><pregnant mothers><pregnant people><pregnant populations><premature childbirth><premature delivery><prenatal><prenatal exposure><prenatally exposed><preterm delivery><prospective><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resolutions><response><risk-reducing><social role><specific biomarkers><those who are pregnant><toxicant><traffic-related air pollution><trial regimen><trial treatment><unborn><vaginal biome><vaginal microbiome><women who are pregnant><youngster>
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Rebecca Knickmeyer

MICHIGAN STATE UNIVERSITY, EAST LANSING, MI

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$644,271
FY 2026

Project Title

Prenatal Maternal Stress, Exposure to Environmental Chemicals, and Cognitive Development: Potential Roles for Inflammation and the Developing Gut Microbiome

Grant Number:

5R01HD107019-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/22/2022

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Prenatal exposure to maternal psychosocial stress and environmental contaminants is associated with reduced cognitive performance in children. However, efforts to support cognitive development in exposed children are hindered by limited understanding of the mechanisms underlying thes...

Research Terms

<0-11 years old><0-4 weeks old><1st trimester><2nd trimester><6 year old><6 years of age><Activities of Daily Living><Activities of everyday life><Address><Adrenaline><Age><American><Ancillary Study><Archives><Area><Biological><Biological Markers><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Serum><Brain><Brain Nervous System><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cells Placenta-Tissue><Chemical Exposure><Child><Child Development><Child Health><Child Youth><Children (0-21)><Cities><Cognition><Cognitive><Communities><Conceptions><DWI (diffusion weighted imaging)><DWI-MRI><Development><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Early Placental Phase><Emotional><Encephalon><Environmental Pollutants><Epidemiology><Epinephrine><Exposure to><Family><First Pregnancy Trimester><First Trimester><GI microbiome><Gestation><Health><Health Priorities><Heavy Metals><Hurricane><Ice><Image><Infant><Infant and Child Development><Inflammation><Inflammatory><Intervention><Interview><Knowledge><Learning><Levarterenol><Levonorepinephrine><Link><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Mediating><Mediator><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Michigan><Midtrimester><Mothers><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Natural Disasters><Natural experiment><Neurites><Newborn Infant><Newborns><Noradrenaline><Norepinephrine><Normal Placentoma><Nuclear Magnetic Resonance Imaging><Nutritional><Outcome><PCBs><Paper><Parents><Pathway interactions><Pattern><Phenotype><Placenta><Placenta Embryonic Tissue><Placentome><Plasma><Plasma Serum><Polychlorinated Biphenyls><Polychlorobiphenyl Compounds><Prefrontal Cortex><Pregnancy><Probability><Process><Protocol><Protocols documentation><Psychosocial Stress><Research><Rest><Reticuloendothelial System, Serum, Plasma><Risk Factors><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Second Pregnancy Trimester><Second Trimester><Serum><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shotguns><Spottings><Stress><Structure><Surface><System><Testing><Therapeutic Epinephrine><Thick><Thickness><Toxicant exposure><United States National Institutes of Health><Urban Community><Urine><Woman><Zeugmatography><age 6><age 6 years><ages><bio-markers><biologic><biologic marker><biomarker><cognitive development><cognitive performance><cohort><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><critical period><dMRI><daily living function><daily living functionality><developmental><diffusion tensor imaging><digestive tract microbiome><enteric microbiome><environmental chemical><environmental contaminant><epidemiologic><epidemiological><experience><experiment><experimental research><experimental study><experiments><exposed in utero><fMRI scan><fecal sample><fetal exposure><fetal stress><functional MRI scan><functional ability><functional capacity><functional magnetic resonance imaging scan><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><imaging><improved><improved outcome><in utero exposure><indexing><inflammation marker><inflammatory marker><intestinal biome><intestinal microbiome><intra-uterine environmental exposure><intrauterine environmental exposure><kids><maternal serum><maternal stress><metagenome><metagenome sequencing><metagenomic sequencing><microbial><microbiome><migration><multi-modal neuro-imaging><multidisciplinary><multimodal neuroimaging><myelination><neural><neural circuit><neural circuitry><neural imaging><neuro-imaging><neurocircuitry><neurocognitive test><neurogenesis><neuroimaging><neurological imaging><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><newborn child><newborn children><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><nutritious><offspring><parent><pathway><polychlorobiphenyl><prenatal><prenatal exposure><prenatal stress><prenatally exposed><psychosocial><psychosocial stresses><psychosocial stressors><recruit><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><shot gun><six year old><six years of age><social role><stool sample><stool specimen><stressed mothers><stressor><substantia alba><suburb><suburban><suburbia><synaptic circuit><synaptic circuitry><toxic exposure><tropical cyclone><unborn><urban area><urban location><urban region><white matter><youngster>
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Noelle Elizabeth Younge

DUKE UNIVERSITY, DURHAM, NC

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$612,587
FY 2026

Project Title

Mechanisms of microbial regulation of postnatal growth and lipid metabolism

Grant Number:

1R01DK142979-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/18/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Infants born extremely preterm commonly experience poor growth and nutrient accretion in the postnatal period, which is independently associated with adverse neurodevelopmental outcomes. We hypothesize that altered development of the microbiome contributes to postnatal growth failure in ext...

Research Terms

<1,2,3-Propanetriol><1,2,3-Trihydroxypropane><Anaerobic Bacteria><Birth><Blood Serum><Body System><Body Tissues><Brain><Brain Nervous System><Calories><Cell Communication and Signaling><Cell Signaling><Chronologic Fetal Maturity><Coliform Bacilli><Communities><Complex><Development><Encephalon><Endocrine Gland Secretion><Engraftment><Enteric Bacteria><Enterobacteria><Enterobacteriaceae><Failure><Fatty Acids><Fetal Age><GI microbiome><Generalized Growth><Gestational Age><Glycerin><Glycerol><Gnotobiotic><Gnotobiotics><Goals><Growth><Growth and Development><Growth and Development function><Hormonal><Hormones><Immune response><Impairment><Infant><Intake><Intermediary Metabolism><Intestinal><Intestines><Intracellular Communication and Signaling><Ketones><Length><Link><Lipolysis><Liver><Mediator><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Microbe><Modification><Murine><Mus><Neonatal><Neurodevelopmental Impairment><Nutrient><Nutrition><Nutritional><Nutritional Support><Organ System><Outcome><Parturition><Pattern><Peripheral><Play><Premature Infant><Process><Proteins><Public Health><Regulation><Research><Risk><Role><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Testing><Therapeutic Hormone><Tissue Growth><Tissues><Weight><Work><absorption><acylcarnitine><anaerobe><biological signal transduction><bowel><calorie><circulating biomarkers><circulating markers><community microbes><critical period><developmental><digestive tract microbiome><enteric microbiome><experience><extreme prematurity><extremely premature infant><extremely preterm><extremely preterm infant><fat metabolism><fatty acid oxidation><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><hepatic body system><hepatic organ system><high risk infant><host response><immune system response><immunoresponse><improved><infants born premature><infants born prematurely><intestinal biome><intestinal microbiome><later in life><later life><lipid metabolism><long-term sequelae><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbiome><microbiota><microflora><microorganism community><multispecies consortia><neonatal mice><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><nutritional care><nutritional therapy><nutritious><ontogeny><polymicrobial community><post-natal period><postnatal><postnatal period><premature baby><premature infant human><premature neonates><premature newborn><preterm baby><preterm infant><preterm infant human><preterm neonate><preterm newborn><prevent><preventing><response><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><uptake><very premature><very preterm><vulnerable infant><weights>
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Stefanie Avril

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$593,363
FY 2026

Project Title

The Microbiome and Mucosal Immunity in Cervical Cancer Disparities

Grant Number:

5R01CA266050-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/25/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The microbiome and mucosal immunity in cervical cancer disparities African American women living in the United States continue to experience an undue higher burden of cervical cancer and a >2 times higher mortality rate than European American women. This survival disparity persists after accounting...

Research Terms

<(TNF)-α><Acceleration><Accounting><Affect><African American><African American Females><African American Women><African Females><African Women><Afro American><Afroamerican><American><Anaerobic Bacteria><Arginine><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Bacteria><Biological Markers><Biology><Body Tissues><Butyrates><Cachectin><Cancer Burden><Cancer Cause><Cancer Etiology><Cancer Induction><Cancers><Cell Body><Cells><Cervical><Cervical Cancer><Cervical Intraepithelial Neoplasia><Cervical Intraepithelial Neoplasms><Cervical Neoplasia><Cervical Neoplasms><Cervical Tumor><Cervix Cancer><Cervix Intraepithelial Neoplasia><Cervix Neoplasms><Cervix Tumor><Cervix Uteri Intraepithelial Neoplasia><Cervix Uteri Neoplasm><Cervix Uteri Tumor><Cessation of life><Checkpoint inhibitor><Classification><Clinic><Cohort Studies><Colposcopy><Communities><Corynebacterium vaginale><Coupled><Data><Data Bases><Databases><Death><Death Rate><Developing Countries><Developing Nations><Disease><Disease Progression><Disease remission><Disorder><Disparities><Disparity><Disseminated Malignant Neoplasm><Dysfunction><Environment><Epithelium><European><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Female><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional Metagenomics><Functional disorder><G vaginalis><G. vaginalis><Gardnerella vaginalis><Gene Expression><Generations><Genes><Genital Organs><Genitalia><H vaginalis><H. vaginalis><HPGF><HPV><HPV-High Risk><Haemophilus vaginalis><Hepatocyte-Stimulating Factor><High Prevalence><High Risk Oncogenic HPV><High risk HPV><High risk Human Papillomavirus><High risk Human papilloma virus><Human Papilloma Virus><Human Papillomavirus><Hybridoma Growth Factor><IDOase><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immune><Immune checkpoint inhibitor><Immune response><Immunes><Immunity><Immunology><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><In Vitro><Indoleamine 2,3-Dioxygenase><Infectious Human Wart Virus><Inflammation><Inflammatory><Infrastructure><Institution><Interleukin-6><Intervention><L-Arginine><L-Tryptophan><Lactobacillus><Less-Developed Countries><Less-Developed Nations><Levotryptophan><Limited Stage><Link><MGI-2><Macrophage-Derived TNF><Malignant Cervical Neoplasm><Malignant Cervical Tumor><Malignant Neoplasm of the Cervix><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Cervix><Malignant Tumor of the Cervix Uteri><Malignant Uterine Cervix Neoplasm><Malignant Uterine Cervix Tumor><Malignant neoplasm of cervix uteri><Measurement><Mechanistic Target of Rapamycin><Mediator><Metagenomics><Metastatic Cancer><Metastatic Malignant Neoplasm><Mice><Mice Mammals><Microbiomics><Mobiluncus><Molecular><Molecular Fingerprinting><Molecular Profiling><Monocyte-Derived TNF><Mucosa><Mucosal Immunity><Mucosal Tissue><Mucous Membrane><Murine><Mus><Myeloid Differentiation-Inducing Protein><National Cancer Burden><Outcome><Pathogenesis><Pathology><Pathway interactions><Persons><Phenotype><Physiopathology><Plasmacytoma Growth Factor><Population><Preventative vaccine><Preventive vaccine><Prevotella><Process><Prophylactic vaccine><Propionates><Prospective Studies><Proteins><RAFT1><Regulatory T-Lymphocyte><Remission><Role><Sampling><Socio-economic status><Socioeconomic Status><Systematics><Systems Biology><T-Cells><T-Lymphocyte><TCGA><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Techniques><The Cancer Genome Atlas><Third-World Countries><Third-World Nations><Tissues><Treatment outcome><Treg><Tryptophan><Tryptophan 2,3 Dioxygenase><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Uganda><Under-Developed Countries><Under-Developed Nations><United States><Uterine Cervix Cancer><Uterine Cervix Intraepithelial Neoplasia><Uterine Cervix Neoplasm><Uterine Cervix Tumor><Vaccines><Vagina><Woman><access to vaccination><access to vaccines><anaerobe><bio-markers><biologic marker><biomarker><cancer disparity><cancer health disparity><cancer progression><cancer risk><cancer-related health disparity><carcinogenesis><carcinogenicity><cohort research study><cohort survey><cost effective><data base><developing country><developing nation><disparity in cancer><disparity in health><dysbacteriosis><dysbiosis><dysbiotic><experience><female genital tract><female outcomes><female reproductive tract><flow cytophotometry><health disparity><high risk><host response><hrHPV><immune check point inhibitor><immune microenvironment><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive microenvironment><immunosuppressive response><immunosuppressive tumor microenvironment><improved><in vivo><interferon beta 2><mTOR><malignancy><mammalian target of rapamycin><metabolism measurement><metabolomics><metabonomics><metaproteomics><microbial><microbial imbalance><microbiome><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microorganism><molecular profile><molecular signature><mortality rate><mouse model><murine model><neoplasm progression><neoplasm/cancer><neoplastic progression><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><outcomes among females><outcomes among women><outcomes in females><outcomes in women><pathophysiology><pathway><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prospective><prospective research study><prospective survey><recruit><regulatory T-cells><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><socio-economic position><socioeconomic position><survival disparity><thymus derived lymphocyte><tryptamine 2,3 dioxygenase><tumor immune microenvironment><tumor progression><tumor-immune system interactions><vaccination access><vaccination availability><vaccine access><vaccine availability><vaginal biome><vaginal microbiome><vaginal mucosa><wart virus><women's genital tract><women's outcomes><women's reproductive tract><♀>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Adam Burgener

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$593,363
FY 2026

Project Title

The Microbiome and Mucosal Immunity in Cervical Cancer Disparities

Grant Number:

5R01CA266050-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/25/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The microbiome and mucosal immunity in cervical cancer disparities African American women living in the United States continue to experience an undue higher burden of cervical cancer and a >2 times higher mortality rate than European American women. This survival disparity persists after accounting...

Research Terms

<(TNF)-α><Acceleration><Accounting><Affect><African American><African American Females><African American Women><African Females><African Women><Afro American><Afroamerican><American><Anaerobic Bacteria><Arginine><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Bacteria><Biological Markers><Biology><Body Tissues><Butyrates><Cachectin><Cancer Burden><Cancer Cause><Cancer Etiology><Cancer Induction><Cancers><Cell Body><Cells><Cervical><Cervical Cancer><Cervical Intraepithelial Neoplasia><Cervical Intraepithelial Neoplasms><Cervical Neoplasia><Cervical Neoplasms><Cervical Tumor><Cervix Cancer><Cervix Intraepithelial Neoplasia><Cervix Neoplasms><Cervix Tumor><Cervix Uteri Intraepithelial Neoplasia><Cervix Uteri Neoplasm><Cervix Uteri Tumor><Cessation of life><Checkpoint inhibitor><Classification><Clinic><Cohort Studies><Colposcopy><Communities><Corynebacterium vaginale><Coupled><Data><Data Bases><Databases><Death><Death Rate><Developing Countries><Developing Nations><Disease><Disease Progression><Disease remission><Disorder><Disparities><Disparity><Disseminated Malignant Neoplasm><Dysfunction><Environment><Epithelium><European><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Female><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional Metagenomics><Functional disorder><G vaginalis><G. vaginalis><Gardnerella vaginalis><Gene Expression><Generations><Genes><Genital Organs><Genitalia><H vaginalis><H. vaginalis><HPGF><HPV><HPV-High Risk><Haemophilus vaginalis><Hepatocyte-Stimulating Factor><High Prevalence><High Risk Oncogenic HPV><High risk HPV><High risk Human Papillomavirus><High risk Human papilloma virus><Human Papilloma Virus><Human Papillomavirus><Hybridoma Growth Factor><IDOase><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immune><Immune checkpoint inhibitor><Immune response><Immunes><Immunity><Immunology><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><In Vitro><Indoleamine 2,3-Dioxygenase><Infectious Human Wart Virus><Inflammation><Inflammatory><Infrastructure><Institution><Interleukin-6><Intervention><L-Arginine><L-Tryptophan><Lactobacillus><Less-Developed Countries><Less-Developed Nations><Levotryptophan><Limited Stage><Link><MGI-2><Macrophage-Derived TNF><Malignant Cervical Neoplasm><Malignant Cervical Tumor><Malignant Neoplasm of the Cervix><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Cervix><Malignant Tumor of the Cervix Uteri><Malignant Uterine Cervix Neoplasm><Malignant Uterine Cervix Tumor><Malignant neoplasm of cervix uteri><Measurement><Mechanistic Target of Rapamycin><Mediator><Metagenomics><Metastatic Cancer><Metastatic Malignant Neoplasm><Mice><Mice Mammals><Microbiomics><Mobiluncus><Molecular><Molecular Fingerprinting><Molecular Profiling><Monocyte-Derived TNF><Mucosa><Mucosal Immunity><Mucosal Tissue><Mucous Membrane><Murine><Mus><Myeloid Differentiation-Inducing Protein><National Cancer Burden><Outcome><Pathogenesis><Pathology><Pathway interactions><Persons><Phenotype><Physiopathology><Plasmacytoma Growth Factor><Population><Preventative vaccine><Preventive vaccine><Prevotella><Process><Prophylactic vaccine><Propionates><Prospective Studies><Proteins><RAFT1><Regulatory T-Lymphocyte><Remission><Role><Sampling><Socio-economic status><Socioeconomic Status><Systematics><Systems Biology><T-Cells><T-Lymphocyte><TCGA><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Techniques><The Cancer Genome Atlas><Third-World Countries><Third-World Nations><Tissues><Treatment outcome><Treg><Tryptophan><Tryptophan 2,3 Dioxygenase><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Uganda><Under-Developed Countries><Under-Developed Nations><United States><Uterine Cervix Cancer><Uterine Cervix Intraepithelial Neoplasia><Uterine Cervix Neoplasm><Uterine Cervix Tumor><Vaccines><Vagina><Woman><access to vaccination><access to vaccines><anaerobe><bio-markers><biologic marker><biomarker><cancer disparity><cancer health disparity><cancer progression><cancer risk><cancer-related health disparity><carcinogenesis><carcinogenicity><cohort research study><cohort survey><cost effective><data base><developing country><developing nation><disparity in cancer><disparity in health><dysbacteriosis><dysbiosis><dysbiotic><experience><female genital tract><female outcomes><female reproductive tract><flow cytophotometry><health disparity><high risk><host response><hrHPV><immune check point inhibitor><immune microenvironment><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive microenvironment><immunosuppressive response><immunosuppressive tumor microenvironment><improved><in vivo><interferon beta 2><mTOR><malignancy><mammalian target of rapamycin><metabolism measurement><metabolomics><metabonomics><metaproteomics><microbial><microbial imbalance><microbiome><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microorganism><molecular profile><molecular signature><mortality rate><mouse model><murine model><neoplasm progression><neoplasm/cancer><neoplastic progression><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><outcomes among females><outcomes among women><outcomes in females><outcomes in women><pathophysiology><pathway><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prospective><prospective research study><prospective survey><recruit><regulatory T-cells><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><socio-economic position><socioeconomic position><survival disparity><thymus derived lymphocyte><tryptamine 2,3 dioxygenase><tumor immune microenvironment><tumor progression><tumor-immune system interactions><vaccination access><vaccination availability><vaccine access><vaccine availability><vaginal biome><vaginal microbiome><vaginal mucosa><wart virus><women's genital tract><women's outcomes><women's reproductive tract><♀>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Philip Lorenzi

BECKMAN RESEARCH INSTITUTE/CITY OF HOPE, DUARTE, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$585,843
FY 2026

Project Title

The role of bile acid metabolomics in graft-versus-host disease

Grant Number:

5R01CA228308-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2024

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Allogeneic hematopoietic cell transplantation (allo-HCT) is a therapy with curative intent for a variety of malignant and non-malignant diseases. One of the major complications after allo-HCT is graft-versus-host disease (GVHD), especially of the gastrointestinal tract. Our group was one of the firs...

Research Terms

<Acids><Acute GVHD><Acute Graft Versus Host Disease><Alimentary Canal><Allogenic><Anaerobic Bacteria><Autoregulation><Bacteria><Bile Acid Biosynthesis><Bile Acid Biosynthesis Pathway><Bile Acids><Binding><Biochemical><Biological><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Serum><Butyrates><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chenic Acid><Chenique Acid><Chenodeoxycholic Acid><Chenodesoxycholic acid><Chenodiol><Chronic GVHD><Clinic><Clinical Research><Clinical Study><Clinical Trials><Collection><Complication><Data><Digestive Physiology><Digestive Tract><Disease><Disease Outcome><Disorder><Engraftment><Enterococcus><Feces><Funding><GI Tract><GI microbiome><GI microbiota><Gallodesoxycholic Acid><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Generations><Goals><GvHD><HSC transplantation><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Henohol><Homeostasis><Homologous Wasting Disease><Human><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><Immunity><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Infection><Inflammation><Innate Immunity><Intestinal GVHD><Intestinal Graft Versus Host Disease><Intracellular Communication and Signaling><Investigation><Liver><Malignant><Malignant - descriptor><Manuscripts><Mice><Mice Mammals><Modern Man><Molecular Interaction><Mucosa><Mucosal Tissue><Mucous Membrane><Multi-center studies><Multicenter Studies><Murine><Mus><NGS Method><NGS system><Native Immunity><Natural Immunity><Nature><Non-Malignant><Non-Specific Immunity><Nonspecific Immunity><Nuclear Receptors><Outcome><Pathology><Patients><Physiological Homeostasis><Plasma><Plasma Serum><Pre-Clinical Model><Preclinical Models><Property><Receptor Activation><Receptor Protein><Recurrent Malignant Neoplasm><Recurrent Malignant Tumor><Regulatory T-Lymphocyte><Relapse><Research><Reticuloendothelial System, Serum, Plasma><Risk><Role><Runt Disease><Sampling><Science><Series><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Streptococcus enterococcus group><T-Cells><T-Lymphocyte><Translating><Transplant Recipients><Treg><Tumor Immunity><Work><acute graft vs host disease><acute graft vs. host disease><adaptive immunity><alimentary tract><anaerobe><anti-microbial><anti-tumor immunity><antimicrobial><antitumor immunity><bacteria pathogen><bacterial pathogen><bile acid anabolism><bile acid biosynthetic process><bile acid formation><bile acid metabolism><bile acid synthesis><bile metabolism><bile salts><biologic><biological signal transduction><blood stem cell transplantation><cancer immunity><cancer recurrence><chronic graft versus host disease><chronic graft vs host disease><chronic graft vs. host disease><commensal bacteria><commensal bacterial species><curative intervention><curative therapeutic><curative therapy><curative treatments><digestive canal><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><experience><gastrointestinal microbial flora><gastrointestinal microbiome><graft versus host disease><graft vs host disease><graft vs. host disease><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><hepatic body system><hepatic organ system><immune reconstitution><improved><improved outcome><infection recurrence><intestinal biome><intestinal epithelium><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><metabolism measurement><metabolomics><metabonomics><microbial><microbial consortia><microbial flora><microbiome><microbiota><microflora><mouse model><multispecies consortia><murine model><next gen sequencing><next generation sequencing><nextgen sequencing><nonmalignant><pathogenic bacteria><pre-clinical study><preclinical study><receptor><reconstitute><reconstitution><recurrent infection><recurring infection><regulatory T-cells><social role><stool><thymus derived lymphocyte><transplant patient><tumor>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Marcel R M van den Brink

BECKMAN RESEARCH INSTITUTE/CITY OF HOPE, DUARTE, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$585,843
FY 2026

Project Title

The role of bile acid metabolomics in graft-versus-host disease

Grant Number:

5R01CA228308-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2024

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Allogeneic hematopoietic cell transplantation (allo-HCT) is a therapy with curative intent for a variety of malignant and non-malignant diseases. One of the major complications after allo-HCT is graft-versus-host disease (GVHD), especially of the gastrointestinal tract. Our group was one of the firs...

Research Terms

<Acids><Acute GVHD><Acute Graft Versus Host Disease><Alimentary Canal><Allogenic><Anaerobic Bacteria><Autoregulation><Bacteria><Bile Acid Biosynthesis><Bile Acid Biosynthesis Pathway><Bile Acids><Binding><Biochemical><Biological><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Serum><Butyrates><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chenic Acid><Chenique Acid><Chenodeoxycholic Acid><Chenodesoxycholic acid><Chenodiol><Chronic GVHD><Clinic><Clinical Research><Clinical Study><Clinical Trials><Collection><Complication><Data><Digestive Physiology><Digestive Tract><Disease><Disease Outcome><Disorder><Engraftment><Enterococcus><Feces><Funding><GI Tract><GI microbiome><GI microbiota><Gallodesoxycholic Acid><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Generations><Goals><GvHD><HSC transplantation><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Henohol><Homeostasis><Homologous Wasting Disease><Human><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><Immunity><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Infection><Inflammation><Innate Immunity><Intestinal GVHD><Intestinal Graft Versus Host Disease><Intracellular Communication and Signaling><Investigation><Liver><Malignant><Malignant - descriptor><Manuscripts><Mice><Mice Mammals><Modern Man><Molecular Interaction><Mucosa><Mucosal Tissue><Mucous Membrane><Multi-center studies><Multicenter Studies><Murine><Mus><NGS Method><NGS system><Native Immunity><Natural Immunity><Nature><Non-Malignant><Non-Specific Immunity><Nonspecific Immunity><Nuclear Receptors><Outcome><Pathology><Patients><Physiological Homeostasis><Plasma><Plasma Serum><Pre-Clinical Model><Preclinical Models><Property><Receptor Activation><Receptor Protein><Recurrent Malignant Neoplasm><Recurrent Malignant Tumor><Regulatory T-Lymphocyte><Relapse><Research><Reticuloendothelial System, Serum, Plasma><Risk><Role><Runt Disease><Sampling><Science><Series><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Streptococcus enterococcus group><T-Cells><T-Lymphocyte><Translating><Transplant Recipients><Treg><Tumor Immunity><Work><acute graft vs host disease><acute graft vs. host disease><adaptive immunity><alimentary tract><anaerobe><anti-microbial><anti-tumor immunity><antimicrobial><antitumor immunity><bacteria pathogen><bacterial pathogen><bile acid anabolism><bile acid biosynthetic process><bile acid formation><bile acid metabolism><bile acid synthesis><bile metabolism><bile salts><biologic><biological signal transduction><blood stem cell transplantation><cancer immunity><cancer recurrence><chronic graft versus host disease><chronic graft vs host disease><chronic graft vs. host disease><commensal bacteria><commensal bacterial species><curative intervention><curative therapeutic><curative therapy><curative treatments><digestive canal><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><experience><gastrointestinal microbial flora><gastrointestinal microbiome><graft versus host disease><graft vs host disease><graft vs. host disease><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><hepatic body system><hepatic organ system><immune reconstitution><improved><improved outcome><infection recurrence><intestinal biome><intestinal epithelium><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><metabolism measurement><metabolomics><metabonomics><microbial><microbial consortia><microbial flora><microbiome><microbiota><microflora><mouse model><multispecies consortia><murine model><next gen sequencing><next generation sequencing><nextgen sequencing><nonmalignant><pathogenic bacteria><pre-clinical study><preclinical study><receptor><reconstitute><reconstitution><recurrent infection><recurring infection><regulatory T-cells><social role><stool><thymus derived lymphocyte><transplant patient><tumor>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Tamar Gur

OHIO STATE UNIVERSITY, Columbus, OH

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$545,605
FY 2026

Project Title

Prenatal neuroinflammation: maternal microbiome contributions and behavioral consequences

Grant Number:

5R01MH129589-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary: Prenatal stress is pervasive and negatively impacts both the mother and the developing fetus; offspring bear an increased risk of aberrant neurodevelopment and psychiatric disorders. Indeed, there is a critical window in utero where neurodevelopment is vulnerable to stress-induced alteratio...

Research Terms

<21+ years old><Adult><Adult Children><Adult Daughters><Adult Human><Adult Offspring><Adult Sons><Anxiety><Automobile Driving><Behavior><Behavioral><Blood Vessels><Blood monocyte><Brain><Brain Nervous System><Breeding><C-C Chemokines><CC Chemokines><CCL2><CCL2 gene><CD11b><CNS Nervous System><CR3A><Cell Body><Cell Line><Cell Survival><Cell Viability><CellLine><Cells><Central Nervous System><Chemokine, CC Motif, Ligand 2><Chemotactic Cytokines><Choroid Plexus><Cytokine Signal Transduction><Cytokine Signaling><Data><Developing fetus><Development><Encephalon><Exhibits><Exposure to><Fetal Development><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Foundations><Future><Gene Modified><Germ-Free><Gestation><Goals><Homologous Chemotactic Cytokines><Hortega cell><ITGAM><ITGAM gene><Immune><Immunes><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Inflammation><Inflammatory><Intercrines><Interdisciplinary Research><Interdisciplinary Study><Intervention><Label><Ligands><Limbic System><Link><MAC1A><MCAF><MCP-1><MCP1><MO1A><Macrophage><Marrow monocyte><Meninges><Mental Depression><Mental disorders><Mental health disorders><Mice><Mice Mammals><Microbe><Microglia><Modeling><Monocyte Chemoattractant Protein-1><Monocyte Chemotactic Protein-1><Monocyte Chemotactic and Activating Factor><Monocyte Chemotactic and Activating Protein><Monocyte Chemotactive and Activating Factor><Monocyte Secretory Protein JE><Mothers><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Myelogenous><Myeloid><Myeloid Cells><Mφ><Neural Development><Neuraxis><Outcome><Pathogenicity><Pathology><Pathway interactions><Play><Population><Prefrontal Cortex><Pregnancy><Production><Psychiatric Disease><Psychiatric Disorder><Resistance><Risk><Role><SCYA2><SIS cytokines><Small Inducible Cytokine A2><Social Behavior><Sorting><Source><Strains Cell Lines><Stress><Structure of choroid plexus><Testing><Time><Transmission><Work><adult animal><adulthood><beta-Chemokines><chemoattractant cytokine><chemokine><community microbes><cultured cell line><cytokine><depression><developmental><driving><experiment><experimental research><experimental study><experiments><fetal><fetal stress><flow cytophotometry><gene modification><genetically modified><gitter cell><gliogenesis><in utero><intrauterine environment><intrauterine milieu><maternal microbiome><mature animal><meninge><mental illness><mesoglia><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbiome><microbiota><microflora><microglial cell><microgliocyte><microorganism community><monocyte><mouse model><multispecies consortia><murine model><neural circuit><neural circuitry><neural inflammation><neurobehavioral><neurocircuitry><neurodevelopment><neuroinflammation><neuroinflammatory><novel><offspring><pathway><perivascular glial cell><polymicrobial community><prenatal><prenatal stress><prevent><preventing><psychiatric illness><psychological disorder><resistant><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social defects><social deficits><social disorders><social dysfunction><social role><sociobehavior><sociobehavioral><synaptic circuit><synaptic circuitry><transmission process><unborn><vascular><β-Chemokines>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ami Siddharth Bhatt

STANFORD UNIVERSITY, STANFORD, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Recent
Active award
$539,000
FY 2026

Project Title

Developing computational, experimental and ecological approaches to study integrated phages and their hosts

Grant Number:

1U01DE035635-01

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/13/2026

End Date:

1/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Bacteriophages are integral components of the human microbiome, shaping microbial diversity and influencing host health, yet our understanding of phage-host dynamics remains limited, particularly for integrated phages. Recent discoveries reveal that lysogenic phages dominate the human gut m...

Research Terms

<Adopted><Affect><Algorithms><Architecture><Bacteria><Bacterial Genome><Bacteriophages><Biology><Bionomics><Biophysics><Classification><Collaborations><Computational toolkit><Computer Models><Computerized Models><Computing Methodologies><DNA><Data><Deoxyribonucleic Acid><Development><Devices><Ecology><Engineering / Architecture><Event><Feces><Frequencies><Functional Metagenomics><Future><GI microbiome><General Taxonomy><Generalized Growth><Genome><Genomics><Goals><Growth><Harvest><Health><Hi-C><Human><Human Microbiome><Immunity><In Situ><In Vitro><Individual><Knowledge><Length><Life Cycle><Life Cycle Stages><Life Style><Lifestyle><Link><Lysogeny><Lytic><Machine Learning><Math Models><Measures><Metagenomics><Methods><Microbiomics><Modeling><Modern Man><Molecular><Optics><Outcome><Phages><Plasmids><Play><Population><Population Dynamics><Prophage Integration><Prophages><Research><Research Resources><Resources><Role><Sampling><Shapes><Structure><Systematics><Taxonomy><Technology><Testing><Therapeutic><Time><Tissue Growth><Viral><Virus><Work><bacterial virus><biophysical foundation><biophysical principles><biophysical sciences><candidate identification><clinical applicability><clinical application><community microbes><computational framework><computational methodology><computational methods><computational modeling><computational models><computational resources><computational suite><computational toolbox><computational tools><computational toolset><computer based method><computer based models><computer framework><computer methods><computerized modeling><computerized tools><computing method><computing resources><contig><density><detector><developmental><digestive tract microbiome><enteric microbiome><fecal sample><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><human-associated microbiome><improved><innovate><innovation><innovative><integration site><interest><intestinal biome><intestinal microbiome><life course><long read seq><long-read sequencing><long-read transcript sequencing><machine based learning><mathematic model><mathematical model><mathematical modeling><metagenome sequencing><metagenomic sequencing><microbe community><microbial><microbial community><microbiome><microbiome research><microbiome science><microbiome studies><microorganism community><multidisciplinary><novel><ontogeny><optical><polymicrobial community><social role><stool><stool sample><stool specimen><structural mutation><structural variant><structural variation><technological innovation><tool>
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Ajit Vikram

UNIVERSITY OF IOWA, IOWA CITY, IA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$505,127
FY 2026

Project Title

Glycopeptide vancomycin reshapes gut microbiota to mediate cardioprotective effects via microRNA-204

Grant Number:

5R01HL167773-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Left ventricular (LV) pressure overload caused by conditions such as chronic hypertension or aortic stenosis is a significant risk factor for the development of heart failure. A decline in microbial diversity caused by certain antibiotics also increases the risk of heart failure, suggesting ...

Research Terms

<APLN><APLN gene><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Aortic Stenosis><Aortic Valve Stenosis><Bacteria><Blood Serum><Body Tissues><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiomyopathies><Cell Communication and Signaling><Cell Signaling><Chronic><Circulation><Cues><Data><Development><Dysfunction><Echocardiogram><Echocardiography><Feces><Fibrosis><Functional RNA><Functional disorder><GI microbiome><GI microbiota><Gastrointestinal microbiota><Glycopeptide Antibiotics><Glycopeptides><Heart><Heart Hypertrophy><Heart Muscle Cells><Heart failure><Heart myocyte><Human><Hypertension><Hypertrophy><Indolylethylamines><Intracellular Communication and Signaling><Intraventricular Pressure><Knowledge><L-Tryptophan><Lactobacillus><Left><Left Ventricular Dysfunction><Left Ventricular Function><Left Ventricular Hypertrophy><Levotryptophan><Measures><Mediating><Mice><Mice Mammals><MicroRNAs><Microbe><Miscellaneous Antibiotic><Modern Man><Molecular><Murine><Mus><Myocardial><Myocardial Diseases><Myocardial Disorder><Myocardial depression><Myocardial dysfunction><Myocardiopathies><Myosin A><Myosin IIA><Non-Muscle Myosin Type IIA><Noncoding RNA><Nonmuscle Myosin Type IIA><Nontranslated RNA><Outcome><Pathologic><Physiologic intraventricular pressure><Physiopathology><Property><Reagent><Receptor Protein><Receptor Signaling><Reporting><Resistance><Risk><Risk Factors><Role><Serum><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Stress><Stretching><Testing><Therapeutic><Tissues><Transthoracic Echocardiography><Tryptamines><Tryptophan><Tryptophan Metabolism><Tryptophan Metabolism Pathway><Untranslated RNA><Upregulation><Vancomycin><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Ventricular><Ventricular Pressure><apelin><bacteria in the gut><bacteria metabolism><bacterial metabolism><biological signal transduction><cardiac dysfunction><cardiac failure><cardiac function><cardiac hypertrophy><cardiomyocyte><cardioprotectant><cardioprotection><cardioprotective><developmental><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><fecal microbial community><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><function of the heart><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heart dysfunction><heart function><heart sonography><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><interstitial><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><left ventricle abnormality><miRNA><microbial><microbiome><myocardium disease><myocardium disorder><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><noncoding><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><overexpress><overexpression><pathophysiology><pressure><prevent><preventing><receptor><resistant><social role><stool><tool>
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Sheldon Rowan

TUFTS UNIVERSITY BOSTON, BOSTON, MA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$504,304
FY 2026

Project Title

Mechanistic understanding of the gut-retina axis

Grant Number:

1R01EY038416-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The risk for age-related macular degeneration (AMD), a leading cause of vision loss in older adults, is dramatically increased in individuals that consume poor diets, characterized by high glycemic index carbohydrates and saturated fats. Conversely, consumption of low glycemic index ...

Research Terms

<21+ years old><5-HT><5-Hydroxytryptamine><5HT><Acids><Adherence><Adult><Adult Human><Advanced Glycation End Products><Advanced Glycosylation End Products><Age Factors><Age related macular degeneration><Age-Related Maculopathy><American><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Atrophic><Atrophy><B thetaiotaomicron><B. thetaiotaomicron><Bacillus thetaiotaomicron><Bacteria><Bacteroides thetaiotaomicron><Bile Acids><Bioinformatics><Biological Monitoring><Blindness><Blood Plasma><Carbohydrates><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Choroid><Clinical><Coin><Communication><Consumption><Custom><Data><Deoxyursocholic Acid><Development><Diet><Dietary Intervention><Dietary Practices><Dietary quality><Disease><Disorder><Dysfunction><Enteramine><Enzyme Gene><Enzymes><Experimental Designs><Eye><Eyeball><Fatty Acids><Fruit><Functional disorder><GI microbiome><GI microbiota><GPBAR1><GPBAR1 gene><Gastrointestinal microbiota><Germ-Free><Glycemic Index><Glycemic Index Number><Goals><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><Health><Hippophaine><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><Immune><Immune system><Immunes><Impairment><Individual><Inflammation><Inflammatory><Innate Immune System><Intake><Intervention><Intestinal><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Intracellular Communication and Signaling><Isocaloric><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Link><Lipofuscin><Macrophage><Measurement><Measures><Mediterranean Diet><Metabolic><Mice><Mice Mammals><Monitor><Murine><Mus><Mφ><Null Mouse><Nutrition Interventions><Nutritional Interventions><Outcome><Outer pigmented layer of retina><Pathway interactions><Physiopathology><Pigment cell layer of retina><Pigmented layer of retina><Plasma><Plasma Serum><Production><Property><Receptor Gene><Receptor Protein><Reticuloendothelial System, Serum, Plasma><Retina><Retinal Degeneration><Retinal Pigment Epithelium><Retinal pigment epithelial cells><Risk><S thetaiotaomicron><S. thetaiotaomicron><Sampling><Serotonin><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Sphaerocillus thetaiotaomicron><Stereotyping><Structure of retinal pigment epithelium><Subcellular Process><TGR5><Testing><Transplantation><Unhealthy Diet><Urine><Ursacholic Acid><Ursodeoxycholic Acid><Ursodiol><Vegetables><Volatile Fatty Acids><Wild Type Mouse><adulthood><advanced glycation endproduct><advanced glycosylation endproduct><age dependent macular degeneration><age induced macular degeneration><age related macular disease><age related macular dystrophy><aged mice><aged mouse><aging prevention><analyze microbiome><anti aging><anti geronic><antiaging><bacteria in the gut><bile salts><biological signal transduction><biomonitoring><bowel><bowel inflammation><candidate identification><commensal bacteria><commensal bacterial species><customs><degenerative retina diseases><design><designing><developmental><diet intervention><diet quality><dietary><dietary fruit><dietary pattern><dietary vegetable><diets><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><elderly mice><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><feeding><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut community><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><immune function><inflamed bowel><inflamed gut><inflamed intestine><innovate><innovation><innovative><interdisciplinary approach><interest><intestinal biome><intestinal flora><intestinal inflammation><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><malleable risk><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbial><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome analysis><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microbiota derived metabolites><microbiota metabolites><microflora><modifiable risk><multidisciplinary approach><multispecies consortia><neuroprotection><neuroprotective><old mice><older adult><older adulthood><pathophysiology><pathway><photoreceptor degeneration><poor diet><prevent><prevent age related><prevent aging><preventing><receptor><reconstitute><reconstitution><retina degeneration><retinal degenerative><retinal degenerative diseases><risk mitigation><saturated dietary fat><saturated dietary lipid><saturated fat><saturated lipid><senile macular disease><suppress aging><systemic inflammation><systemic inflammatory response><transplant><vision loss><visual loss><whole grain><wildtype mouse>
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Lisa Ann Beck

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

High-opportunity lead · 74/100
Likely hiring
Solid budget
Very recent
Active award
$462,039
FY 2026

Project Title

Biomarker Identification, Viral Susceptibility and Management in S. aureus Colonized AD Patients

Grant Number:

5U01AI152011-07

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/6/2020

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Staphylococcus aureus (S. aureus) has been strongly implicated as a causal factor in pathogenesis of atopic dermatitis (AD) since the 1970s, and is further supported by publications demonstrating S. aureus skin colonization precedes AD onset. ADRN studies found that 50% of ...

Research Terms

<0-11 years old><Acne><Affect><Applications Grants><Atopic Dermatitis><Atopic Eczema><Atopic Neurodermatitis><Bacteria><Biological><Biological Markers><Biology><Blood Serum><Cell Body><Cells><Child><Child Youth><Children (0-21)><Circulation><Clinical><Coupled><Cutaneous Disorder><Cutaneous viral infections><Data><Dermatoses><Disseminated Neurodermatitis><Dysfunction><Eczema Herpeticum><Eczema Vaccinatum><Enrollment><Epithelium><Experimental Designs><Exposure to><Fatality rate><Functional disorder><Generalized Growth><Genome><Grant Proposals><Growth><HSV><Herpes Simplex Virus><Herpes labialis Virus><Human><Immune Targeting><Immunity><Individual><Inflammatory><Measures><Mediating><Microbe><Modern Man><Pathogenesis><Pathogenicity Factors><Patients><Phenotype><Physiopathology><Play><Poxvirus officinale><Predisposition><Production><Publications><Registries><Ribosomal RNA><Role><S aureus><S. aureus><SYS-TX><Scientific Publication><Serum><Severities><Severity of illness><Simplexvirus><Site><Skin><Skin Diseases><Skin Diseases and Manifestations><Skin colonization><Smallpox><Smallpox Vaccine><Staph aureus><Staphylococcus aureus><Surface><Susceptibility><Systemic Therapy><Testing><Tissue Growth><Vaccination><Vaccinia virus><Variola><Viral><Viral Diseases><Viral Skin Diseases><Viral skin infections><Virulence Factors><Virulent><Virus Diseases><allergic dermatitis><allergic eczema><bio-markers><biologic><biologic marker><biomarker><biomarker array><biomarker identification><biomarker panel><clinical predictors><commensal bacteria><commensal bacterial species><cutaneous barrier><cutaneous disease><cutaneous microbiome><cutaneous microbiota><dermal barrier><dermal disease><dermal disorder><dermal microbiome><dermal microbiota><disease severity><enhancing factor><enroll><epidermal barrier><epidermal microbiome><experience><gene product><identification of biomarkers><identification of new biomarkers><kids><marker identification><marker panel><microbiome><ontogeny><pathogen><pathophysiology><permissiveness><prospective><rRNA><recombinant vaccinia virus><recruit><response><response to therapy><response to treatment><skin barrier><skin biome><skin disorder><skin flora><skin microbial community><skin microbiome><skin microbiota><skin microflora><small pox><small pox vaccine><social role><systemic inflammation><systemic inflammatory response><therapeutic response><therapy response><treatment response><treatment responsiveness><variola major><viral infection><virus infection><virus-induced disease><youngster>
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Joao Xavier

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$3,519,992
FY 2026

Project Title

Understanding and manipulating microbiome ecology to curb gut-borne infections.

Grant Number:

1R01AI196346-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

SUMMARY/ABSTRACT Gut-borne bloodstream infections are a significant cause of morbidity and mortality in immunocompromised patients, often leading to sepsis and poor clinical outcomes. Despite their severity, current clinical approaches rely on reactive antibiotic treatments, which fail to address th...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Address><Algorithms><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Bacteria><Bionomics><Blood><Blood Circulation><Blood Reticuloendothelial System><Bloodstream><Caring><Clinical><Clinical Data><Computational toolkit><Computer Assisted><Computer Models><Computerized Models><Data><Data Analyses><Data Analysis><Data Set><Differential Algebraic Equation><Differential Equation><Drugs><E coli><E faecium><E. coli><E. faecium><Early identification><Ecologic Systems><Ecological Systems><Ecology><Ecosystem><Ensure><Enterococcus faecium><Escherichia coli><Event><Functional Metagenomics><Future><GI microbiome><Gnotobiotic><Gnotobiotics><Guidelines><Health><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><In Vitro><Individual><Infection><Infection Control><Infection prevention><Intervention><Intestinal><Intestines><K pneumoniae><K. pneumoniae><Klebsiella pneumoniae><MSKCC><Machine Learning><Math Models><Mediating><Medication><Memorial Sloan-Kettering Cancer Center><Metadata><Metagenomics><Methods><Mice><Mice Mammals><Microbiomics><Miscellaneous Antibiotic><Modeling><Molecular><Morbidity><Murine><Mus><Outcome><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pharmaceutical Preparations><Population><Prevent infection><Probiotics><Process><Regimen><Research><Resistance><Resistance to antibiotics><Resistant to antibiotics><Risk><Risk Reduction><S faceium><S faecium><S. faceium><S. faecium><Sepsis><Severities><Shotguns><Streptococcus faceium><Streptococcus faecium><Testing><Translating><Treatment Efficacy><Validation><Work><antibiotic drug resistance><antibiotic resistant><bacteria in the gut><bacterial disease treatment><bacterial infectious disease treatment><blood infection><bloodstream infection><bowel><clinical decision-making><clinical relevance><clinically actionable><clinically relevant><cohort><colonization resistance><combat><commensal bacteria><commensal bacterial species><commensal flora><commensal microbes><commensal microbiota><commensal microflora><community microbes><computational modeling><computational models><computational toolbox><computational tools><computational toolset><computer aided><computer based models><computerized modeling><computerized tools><data infrastructure><data interpretation><design><designing><digestive tract microbiome><discrete time><drug/agent><enteric microbiome><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbiome><gut bacteria><gut microbiome><gut-associated microbiome><high risk><immunological status><immunosuppressed patient><improved><improved outcome><in vivo Model><infection in the blood><infection management><infection of the blood><infection rate><infection risk><insight><intervention efficacy><intestinal biome><intestinal microbiome><longitudinal data set><longitudinal dataset><machine based learning><mathematic model><mathematical model><mathematical modeling><meta data><metabolism measurement><metabolomics><metabonomics><microbe community><microbial community><microbiome><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microorganism community><mortality><mouse model><murine model><neural><opportunistic pathogen><pathogen><patient oriented outcomes><polymicrobial community><preservation><prevent><preventing><rate of infection><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resilience><resilient><resistant><risk-reducing><shot gun><theories><therapeutic efficacy><therapy efficacy><tool><validations>
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Vanni Bucci

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 68/100
Likely hiring
Above-average budget
Active award
Team-scale grant
$586,150
FY 2026

Project Title

Development of targeted microbiome therapeutics and dietary interventions for potent intestinal barrier promotion to minimize GI-ARS

Grant Number:

5U01AI172987-04

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/22/2022

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Exposure to total body irradiation (TBI) produced by nuclear accidents, premeditated nuclear, or terrorist attack causes gastrointestinal (GI) acute radiation syndrome (GI-ARS), a state of severe intestinal mucosal barrier damage, loss of tissue integrity, and translocation of the luminal c...

Research Terms

<ABC20><ABCB1><ABCB1 gene><Acute Radiation Syndrome><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Atomic Warfare><Autoregulation><Bacteria><Bacteroides><Bile Acids><Biologic Models><Biological Models><Biological Response Modifier Therapy><Biological Therapy><Body Tissues><Butyrates><Cessation of life><Clinical><Data><Data Analyses><Data Analysis><Death><Development><Diet><Dietary Component><Dietary Intervention><E coli><E. coli><Encapsulated><Engineered Probiotics><Engineering><Environment><Epithelium><Escherichia coli><Exposure to><Freeze Drying><Freeze Dryings><Functional Metagenomics><GI colonization><GI microbiome><GI microbiota><GP170><Gastrointestinal microbiota><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Homeostasis><Hour><Human><Immunity><In Vitro><Infection><Inflammatory><Intestinal><Intestines><Lyophilization><MDR-1><MDR1><MDR1 Protein><Maintenance><Math Models><Measures><Meditation><Metagenomics><Microbe><Miscellaneous Antibiotic><Model System><Modern Man><Modified Probiotics><Mucosa><Mucosal Tissue><Mucous Membrane><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><Nuclear Accidents><Nuclear Warfare><Nutrition Interventions><Nutritional Interventions><Oral><Oral Administration><Oral Drug Administration><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PGY-1 Protein><PGY1><Pathway interactions><Personal Satisfaction><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Physiology><Play><Probiotic Engineering><Probiotics><Production><Radiation><Radiation Biology><Radiation Toxicity><Radiation exposure><Radiobiology><Radiotoxicity><Receptor Protein><Recombinant DNA Technology><Recovery><Resistance><Role><Sampling><Sepsis><Succinates><Supplementation><Surface><System><Temperature><Terrorism><Testing><Therapeutic><Therapeutic Agents><Therapeutic Intervention><Tissues><Total Body Irradiation><Whole-Body Irradiation><Whole-Body Radiation><Work><biological therapeutic><biological treatment><biologically based therapeutics><biotherapeutics><biotherapy><bowel><data interpretation><developmental><diet intervention><diets><digestive tract microbiome><dynamic system><dynamical system><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><gastrointestinal><gastrointestinal bacteria><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><genetically engineered><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><improved><in vivo><in vivo Model><interest><intervention therapy><intestinal barrier><intestinal biome><intestinal colonization><intestinal epithelium><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal mucosal barrier><intestinal tract microflora><intraoral drug delivery><irradiation><mathematic model><mathematical model><mathematical modeling><medical countermeasure><member><microbial imbalance><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><novel><nuclear attack><nuclear disaster><nuclear event><nuclear incident><pathway><permissiveness><prebiotics><radiation poisoning><receptor><resistant><social role><synthetic biology><terrorist attack><tissue repair><tool><well-being><wellbeing><β-Glucans>
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Beth A McCormick

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 68/100
Likely hiring
Above-average budget
Active award
Team-scale grant
$586,150
FY 2026

Project Title

Development of targeted microbiome therapeutics and dietary interventions for potent intestinal barrier promotion to minimize GI-ARS

Grant Number:

5U01AI172987-04

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/22/2022

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Exposure to total body irradiation (TBI) produced by nuclear accidents, premeditated nuclear, or terrorist attack causes gastrointestinal (GI) acute radiation syndrome (GI-ARS), a state of severe intestinal mucosal barrier damage, loss of tissue integrity, and translocation of the luminal c...

Research Terms

<ABC20><ABCB1><ABCB1 gene><Acute Radiation Syndrome><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Atomic Warfare><Autoregulation><Bacteria><Bacteroides><Bile Acids><Biologic Models><Biological Models><Biological Response Modifier Therapy><Biological Therapy><Body Tissues><Butyrates><Cessation of life><Clinical><Data><Data Analyses><Data Analysis><Death><Development><Diet><Dietary Component><Dietary Intervention><E coli><E. coli><Encapsulated><Engineered Probiotics><Engineering><Environment><Epithelium><Escherichia coli><Exposure to><Freeze Drying><Freeze Dryings><Functional Metagenomics><GI colonization><GI microbiome><GI microbiota><GP170><Gastrointestinal microbiota><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Homeostasis><Hour><Human><Immunity><In Vitro><Infection><Inflammatory><Intestinal><Intestines><Lyophilization><MDR-1><MDR1><MDR1 Protein><Maintenance><Math Models><Measures><Meditation><Metagenomics><Microbe><Miscellaneous Antibiotic><Model System><Modern Man><Modified Probiotics><Mucosa><Mucosal Tissue><Mucous Membrane><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><Nuclear Accidents><Nuclear Warfare><Nutrition Interventions><Nutritional Interventions><Oral><Oral Administration><Oral Drug Administration><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PGY-1 Protein><PGY1><Pathway interactions><Personal Satisfaction><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Physiology><Play><Probiotic Engineering><Probiotics><Production><Radiation><Radiation Biology><Radiation Toxicity><Radiation exposure><Radiobiology><Radiotoxicity><Receptor Protein><Recombinant DNA Technology><Recovery><Resistance><Role><Sampling><Sepsis><Succinates><Supplementation><Surface><System><Temperature><Terrorism><Testing><Therapeutic><Therapeutic Agents><Therapeutic Intervention><Tissues><Total Body Irradiation><Whole-Body Irradiation><Whole-Body Radiation><Work><biological therapeutic><biological treatment><biologically based therapeutics><biotherapeutics><biotherapy><bowel><data interpretation><developmental><diet intervention><diets><digestive tract microbiome><dynamic system><dynamical system><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><gastrointestinal><gastrointestinal bacteria><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><genetically engineered><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><improved><in vivo><in vivo Model><interest><intervention therapy><intestinal barrier><intestinal biome><intestinal colonization><intestinal epithelium><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal mucosal barrier><intestinal tract microflora><intraoral drug delivery><irradiation><mathematic model><mathematical model><mathematical modeling><medical countermeasure><member><microbial imbalance><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><novel><nuclear attack><nuclear disaster><nuclear event><nuclear incident><pathway><permissiveness><prebiotics><radiation poisoning><receptor><resistant><social role><synthetic biology><terrorist attack><tissue repair><tool><well-being><wellbeing><β-Glucans>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Darby Jack

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 66/100
Likely hiring
Large award
Active award
$1,231,131
FY 2026

Project Title

Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the GRAPHS randomized controlled trial

Grant Number:

5R01ES035791-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/17/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project summary In low- and middle-income countries ~2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M disability adjusted life years in 2019. A large proportion of HAP-attributable deaths are due t...

Research Terms

<0-11 years old><1 year of age><1 year old><13 year old><13 years of age><16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><3-D><3-Dimensional><3D><4 year old><4 years of age><5 year old><5 years of age><Address><Age><Air Pollution><Animal Model><Animal Models and Related Studies><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Asthma><Bacteria><Bacteriophages><Biogenesis><Birth><Breathing><Bronchial Asthma><Carbon Monoxide><Causality><Cessation of life><Child><Child Youth><Childhood><Children (0-21)><Communities><Crude Oil><DALY><Death><Development><Disease><Disorder><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Epidemiology><Etiology><Exposure Assessment><Feces><Fire - disasters><Fires><Functional Metagenomics><Future><GI microbiome><Gases><Generalized Growth><Gestation><Ghana><Gold Coast><Grant><Growth><Health><Heterogeneity><Household><Household Air Pollution><Human><Human Microbiome><Hybrid capture><Hybridization capture><Infant><Intention><Intervention><Investments><LMIC><Life><Life Cycle><Life Cycle Stages><Link><Lung Diseases><Measurement><Mediating><Metagenomics><Methods><Modern Man><Origin of Life><Outcome Assessment><PM2.5><Parturition><Persons><Petroleum><Phages><Phenotype><Pneumonia><Policies><Pregnancy><Pregnant Women><Preventative intervention><Process><Public Health><Pulmonary Diseases><Pulmonary Disorder><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Randomized, Controlled Trials><Research><Research Grants><Research Project Grants><Research Projects><Respiratory Aspiration><Respiratory Disease><Respiratory Inspiration><Respiratory System Disease><Respiratory System Disorder><Risk><Risk Reduction><Shotguns><Smoke><Therapeutic Intervention><Time><Tissue Growth><Viral><Virus><Wood><Wood material><Work><age 1><age 1 year><age 13><age 13 years><age 4><age 4 years><age 5><age 5 years><aged 1 year><aged one year><ages><arm><attributable death><attributable mortality><bacterial microbiome><bacterial virus><bacteriome><biomarker identification><candidate identification><causation><childhood gut microbiome><cohort><compare to control><comparison control><cooking><cost effective><developmental><digestive tract microbiome><disability-adjusted life years><discrete time><disease causation><disease of the lung><disease risk><disorder of the lung><disorder risk><early biomarkers><early detection biomarkers><early detection markers><enteric microbiome><environmental risk><epidemiologic><epidemiological><evidence base><expectant mother><expectant women><expecting mother><expecting women><exposure analysis><exposure evaluation><exposure measurement><exposure profiling><exposure survey><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><fine particles><fine particulate matter><fire><five year old><five years of age><four year old><four years of age><fungus><gastrointestinal microbiome><gut microbiome><gut microbiome of infant><gut-associated microbiome><human flora><human microbial communities><human microbiota><human microflora><human virome><human-associated microbial communities><human-associated microbiome><human-associated microbiota><hybridization-based capture><identification of biomarkers><identification of new biomarkers><improved><individuals who are pregnant><infancy><infant gut microbiome><infantile><inspiration><intervention for prevention><intervention therapy><intestinal biome><intestinal microbiome><kids><life course><low and middle-income countries><lung disorder><lung function><lung health><marker identification><maternal microbiome><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome signature><model of animal><neonate gut microbiome><newborn gut microbiome><novel><one year of age><one year old><ontogeny><pediatric><pediatric gut microbiome><people who are pregnant><petroleum oil><pollutant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prevention intervention><preventional intervention strategy><preventive intervention><programs><public health intervention><pulmonary function><pulmonary health><randomisation><randomization><randomized control study><randomized control trial><randomized, controlled study><randomly assigned><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><residential air pollution><response><risk-reducing><shot gun><stool><stool sample><stool specimen><thirteen year old><thirteen years of age><those who are pregnant><three dimensional><treatment group><unborn><viral microbiome><virome><women who are pregnant><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Peggy Sue Lai

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 66/100
Likely hiring
Large award
Active award
$1,231,131
FY 2026

Project Title

Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the GRAPHS randomized controlled trial

Grant Number:

5R01ES035791-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/17/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project summary In low- and middle-income countries ~2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M disability adjusted life years in 2019. A large proportion of HAP-attributable deaths are due t...

Research Terms

<0-11 years old><1 year of age><1 year old><13 year old><13 years of age><16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><3-D><3-Dimensional><3D><4 year old><4 years of age><5 year old><5 years of age><Address><Age><Air Pollution><Animal Model><Animal Models and Related Studies><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Asthma><Bacteria><Bacteriophages><Biogenesis><Birth><Breathing><Bronchial Asthma><Carbon Monoxide><Causality><Cessation of life><Child><Child Youth><Childhood><Children (0-21)><Communities><Crude Oil><DALY><Death><Development><Disease><Disorder><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Epidemiology><Etiology><Exposure Assessment><Feces><Fire - disasters><Fires><Functional Metagenomics><Future><GI microbiome><Gases><Generalized Growth><Gestation><Ghana><Gold Coast><Grant><Growth><Health><Heterogeneity><Household><Household Air Pollution><Human><Human Microbiome><Hybrid capture><Hybridization capture><Infant><Intention><Intervention><Investments><LMIC><Life><Life Cycle><Life Cycle Stages><Link><Lung Diseases><Measurement><Mediating><Metagenomics><Methods><Modern Man><Origin of Life><Outcome Assessment><PM2.5><Parturition><Persons><Petroleum><Phages><Phenotype><Pneumonia><Policies><Pregnancy><Pregnant Women><Preventative intervention><Process><Public Health><Pulmonary Diseases><Pulmonary Disorder><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Randomized, Controlled Trials><Research><Research Grants><Research Project Grants><Research Projects><Respiratory Aspiration><Respiratory Disease><Respiratory Inspiration><Respiratory System Disease><Respiratory System Disorder><Risk><Risk Reduction><Shotguns><Smoke><Therapeutic Intervention><Time><Tissue Growth><Viral><Virus><Wood><Wood material><Work><age 1><age 1 year><age 13><age 13 years><age 4><age 4 years><age 5><age 5 years><aged 1 year><aged one year><ages><arm><attributable death><attributable mortality><bacterial microbiome><bacterial virus><bacteriome><biomarker identification><candidate identification><causation><childhood gut microbiome><cohort><compare to control><comparison control><cooking><cost effective><developmental><digestive tract microbiome><disability-adjusted life years><discrete time><disease causation><disease of the lung><disease risk><disorder of the lung><disorder risk><early biomarkers><early detection biomarkers><early detection markers><enteric microbiome><environmental risk><epidemiologic><epidemiological><evidence base><expectant mother><expectant women><expecting mother><expecting women><exposure analysis><exposure evaluation><exposure measurement><exposure profiling><exposure survey><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><fine particles><fine particulate matter><fire><five year old><five years of age><four year old><four years of age><fungus><gastrointestinal microbiome><gut microbiome><gut microbiome of infant><gut-associated microbiome><human flora><human microbial communities><human microbiota><human microflora><human virome><human-associated microbial communities><human-associated microbiome><human-associated microbiota><hybridization-based capture><identification of biomarkers><identification of new biomarkers><improved><individuals who are pregnant><infancy><infant gut microbiome><infantile><inspiration><intervention for prevention><intervention therapy><intestinal biome><intestinal microbiome><kids><life course><low and middle-income countries><lung disorder><lung function><lung health><marker identification><maternal microbiome><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome signature><model of animal><neonate gut microbiome><newborn gut microbiome><novel><one year of age><one year old><ontogeny><pediatric><pediatric gut microbiome><people who are pregnant><petroleum oil><pollutant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prevention intervention><preventional intervention strategy><preventive intervention><programs><public health intervention><pulmonary function><pulmonary health><randomisation><randomization><randomized control study><randomized control trial><randomized, controlled study><randomly assigned><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><residential air pollution><response><risk-reducing><shot gun><stool><stool sample><stool specimen><thirteen year old><thirteen years of age><those who are pregnant><three dimensional><treatment group><unborn><viral microbiome><virome><women who are pregnant><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Alison G Lee

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 66/100
Likely hiring
Large award
Active award
$1,231,131
FY 2026

Project Title

Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the GRAPHS randomized controlled trial

Grant Number:

5R01ES035791-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/17/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project summary In low- and middle-income countries ~2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M disability adjusted life years in 2019. A large proportion of HAP-attributable deaths are due t...

Research Terms

<0-11 years old><1 year of age><1 year old><13 year old><13 years of age><16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><3-D><3-Dimensional><3D><4 year old><4 years of age><5 year old><5 years of age><Address><Age><Air Pollution><Animal Model><Animal Models and Related Studies><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Asthma><Bacteria><Bacteriophages><Biogenesis><Birth><Breathing><Bronchial Asthma><Carbon Monoxide><Causality><Cessation of life><Child><Child Youth><Childhood><Children (0-21)><Communities><Crude Oil><DALY><Death><Development><Disease><Disorder><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Epidemiology><Etiology><Exposure Assessment><Feces><Fire - disasters><Fires><Functional Metagenomics><Future><GI microbiome><Gases><Generalized Growth><Gestation><Ghana><Gold Coast><Grant><Growth><Health><Heterogeneity><Household><Household Air Pollution><Human><Human Microbiome><Hybrid capture><Hybridization capture><Infant><Intention><Intervention><Investments><LMIC><Life><Life Cycle><Life Cycle Stages><Link><Lung Diseases><Measurement><Mediating><Metagenomics><Methods><Modern Man><Origin of Life><Outcome Assessment><PM2.5><Parturition><Persons><Petroleum><Phages><Phenotype><Pneumonia><Policies><Pregnancy><Pregnant Women><Preventative intervention><Process><Public Health><Pulmonary Diseases><Pulmonary Disorder><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Randomized, Controlled Trials><Research><Research Grants><Research Project Grants><Research Projects><Respiratory Aspiration><Respiratory Disease><Respiratory Inspiration><Respiratory System Disease><Respiratory System Disorder><Risk><Risk Reduction><Shotguns><Smoke><Therapeutic Intervention><Time><Tissue Growth><Viral><Virus><Wood><Wood material><Work><age 1><age 1 year><age 13><age 13 years><age 4><age 4 years><age 5><age 5 years><aged 1 year><aged one year><ages><arm><attributable death><attributable mortality><bacterial microbiome><bacterial virus><bacteriome><biomarker identification><candidate identification><causation><childhood gut microbiome><cohort><compare to control><comparison control><cooking><cost effective><developmental><digestive tract microbiome><disability-adjusted life years><discrete time><disease causation><disease of the lung><disease risk><disorder of the lung><disorder risk><early biomarkers><early detection biomarkers><early detection markers><enteric microbiome><environmental risk><epidemiologic><epidemiological><evidence base><expectant mother><expectant women><expecting mother><expecting women><exposure analysis><exposure evaluation><exposure measurement><exposure profiling><exposure survey><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><fine particles><fine particulate matter><fire><five year old><five years of age><four year old><four years of age><fungus><gastrointestinal microbiome><gut microbiome><gut microbiome of infant><gut-associated microbiome><human flora><human microbial communities><human microbiota><human microflora><human virome><human-associated microbial communities><human-associated microbiome><human-associated microbiota><hybridization-based capture><identification of biomarkers><identification of new biomarkers><improved><individuals who are pregnant><infancy><infant gut microbiome><infantile><inspiration><intervention for prevention><intervention therapy><intestinal biome><intestinal microbiome><kids><life course><low and middle-income countries><lung disorder><lung function><lung health><marker identification><maternal microbiome><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome signature><model of animal><neonate gut microbiome><newborn gut microbiome><novel><one year of age><one year old><ontogeny><pediatric><pediatric gut microbiome><people who are pregnant><petroleum oil><pollutant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prevention intervention><preventional intervention strategy><preventive intervention><programs><public health intervention><pulmonary function><pulmonary health><randomisation><randomization><randomized control study><randomized control trial><randomized, controlled study><randomly assigned><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><residential air pollution><response><risk-reducing><shot gun><stool><stool sample><stool specimen><thirteen year old><thirteen years of age><those who are pregnant><three dimensional><treatment group><unborn><viral microbiome><virome><women who are pregnant><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Mehmet Asim Bilen

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$927,329
FY 2026

Project Title

Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma

Grant Number:

5R01CA255322-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT In 2021, approximately 76,080 individuals in the United States will be diagnosed with kidney cancer, with renal cell carcinoma (RCC) accounting for >90% of all cases. Approximately 25% of patients with RCC present with metastasis at the time of initial diagnosis and up to 20-30% of patients...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Accounting><Adverse Experience><Adverse event><After Care><After-Treatment><Aftercare><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Butyrates><Cancer Center><Cancer Patient><Cancer Treatment><Cancers><Caucasian male><Caucasian men><Checkpoint inhibitor><Clinical><Complex><Data><Development><Diagnosis><Diet><Diet Modification><Dietary Modifications><Disease Progression><Disease remission><Drugs><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Freezing><Future><GI microbiome><Genes><Goals><Grawitz Tumor><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Host Factor><Host Factor Protein><Human Microbiome><Hypernephroid Carcinoma><Hypernephroma><Immune checkpoint inhibitor><Immune mediated therapy><Immunologically Directed Therapy><Immunotherapy><Individual><Inflammation><Integration Host Factors><Kidney Cancer><Kidney Carcinoma><Life Style><Lifestyle><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measurement><Mediating><Medication><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Neoplasm Metastasis><Nephrectomy><Nephroid Carcinoma><Outcome><Pathogenesis><Pathway interactions><Patient Recruitments><Patient Selection><Patient risk><Patients><Pharmaceutical Preparations><Phase><Preventative strategy><Prevention strategy><Preventive strategy><Production><Progression-Free Survivals><Questionnaires><Race><Races><Racial Group><Recommendation><Recurrent disease><Relapsed Disease><Remission><Renal Adenocarcinoma><Renal Cancer><Renal Carcinoma><Renal Cell Adenocarcinoma><Renal Cell Cancer><Renal Cell Carcinoma><Reporting><Research><Resolution><Risk><Role><Secondary Neoplasm><Secondary Tumor><Short-Chain Fatty Acids><Shotguns><Specific qualifier value><Specified><Supplementation><T-Cell Activation><Time><Toxin><Treatment outcome><Treatment-related toxicity><United States><Universities><Validation><Volatile Fatty Acids><Woman><activate T cells><anti-cancer immunotherapy><anti-cancer therapy><anticancer immunotherapy><bio-markers><biologic marker><biomarker><cancer immunotherapy><cancer metastasis><cancer therapy><cancer-directed therapy><demographics><design><designing><developmental><diet alteration><dietary alteration><diets><digestive tract microbiome><drug/agent><enteric microbiome><entire genome><ethnic subgroup><ethnicity group><experience><fecal sample><full genome><gastrointestinal microbiome><gut microbes><gut microbial species><gut microbiome><gut-associated microbiome><human-associated microbiome><immune check point inhibitor><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapies><immune-based treatments><immuno therapy><immunotherapy for cancer><immunotherapy of cancer><improved><intestinal biome><intestinal microbes><intestinal microbiome><kidney adenocarcinoma><malignancy><men><metagenome sequencing><metagenomic sequencing><microbial><microbiome><neoplasm/cancer><participant recruitment><pathway><post treatment><prebiotics><prevent><preventing><prospective><racial><racial background><racial origin><racial population><racial subgroup><resolutions><response><response to therapy><response to treatment><risk stratification><sex><shot gun><social role><standard of care><stool sample><stool specimen><stratify risk><therapeutic response><therapeutic toxicity><therapy associated toxicity><therapy related toxicity><therapy response><therapy toxicity><treatment response><treatment responsiveness><treatment toxicity><treatment-associated toxicity><tumor cell metastasis><validations><white male><white men><whole genome>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Veronika Fedirko

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$927,329
FY 2026

Project Title

Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma

Grant Number:

5R01CA255322-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT In 2021, approximately 76,080 individuals in the United States will be diagnosed with kidney cancer, with renal cell carcinoma (RCC) accounting for >90% of all cases. Approximately 25% of patients with RCC present with metastasis at the time of initial diagnosis and up to 20-30% of patients...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Accounting><Adverse Experience><Adverse event><After Care><After-Treatment><Aftercare><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Butyrates><Cancer Center><Cancer Patient><Cancer Treatment><Cancers><Caucasian male><Caucasian men><Checkpoint inhibitor><Clinical><Complex><Data><Development><Diagnosis><Diet><Diet Modification><Dietary Modifications><Disease Progression><Disease remission><Drugs><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Freezing><Future><GI microbiome><Genes><Goals><Grawitz Tumor><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Host Factor><Host Factor Protein><Human Microbiome><Hypernephroid Carcinoma><Hypernephroma><Immune checkpoint inhibitor><Immune mediated therapy><Immunologically Directed Therapy><Immunotherapy><Individual><Inflammation><Integration Host Factors><Kidney Cancer><Kidney Carcinoma><Life Style><Lifestyle><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measurement><Mediating><Medication><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Neoplasm Metastasis><Nephrectomy><Nephroid Carcinoma><Outcome><Pathogenesis><Pathway interactions><Patient Recruitments><Patient Selection><Patient risk><Patients><Pharmaceutical Preparations><Phase><Preventative strategy><Prevention strategy><Preventive strategy><Production><Progression-Free Survivals><Questionnaires><Race><Races><Racial Group><Recommendation><Recurrent disease><Relapsed Disease><Remission><Renal Adenocarcinoma><Renal Cancer><Renal Carcinoma><Renal Cell Adenocarcinoma><Renal Cell Cancer><Renal Cell Carcinoma><Reporting><Research><Resolution><Risk><Role><Secondary Neoplasm><Secondary Tumor><Short-Chain Fatty Acids><Shotguns><Specific qualifier value><Specified><Supplementation><T-Cell Activation><Time><Toxin><Treatment outcome><Treatment-related toxicity><United States><Universities><Validation><Volatile Fatty Acids><Woman><activate T cells><anti-cancer immunotherapy><anti-cancer therapy><anticancer immunotherapy><bio-markers><biologic marker><biomarker><cancer immunotherapy><cancer metastasis><cancer therapy><cancer-directed therapy><demographics><design><designing><developmental><diet alteration><dietary alteration><diets><digestive tract microbiome><drug/agent><enteric microbiome><entire genome><ethnic subgroup><ethnicity group><experience><fecal sample><full genome><gastrointestinal microbiome><gut microbes><gut microbial species><gut microbiome><gut-associated microbiome><human-associated microbiome><immune check point inhibitor><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapies><immune-based treatments><immuno therapy><immunotherapy for cancer><immunotherapy of cancer><improved><intestinal biome><intestinal microbes><intestinal microbiome><kidney adenocarcinoma><malignancy><men><metagenome sequencing><metagenomic sequencing><microbial><microbiome><neoplasm/cancer><participant recruitment><pathway><post treatment><prebiotics><prevent><preventing><prospective><racial><racial background><racial origin><racial population><racial subgroup><resolutions><response><response to therapy><response to treatment><risk stratification><sex><shot gun><social role><standard of care><stool sample><stool specimen><stratify risk><therapeutic response><therapeutic toxicity><therapy associated toxicity><therapy related toxicity><therapy response><therapy toxicity><treatment response><treatment responsiveness><treatment toxicity><treatment-associated toxicity><tumor cell metastasis><validations><white male><white men><whole genome>
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Gregory Lance Peck

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$816,524
FY 2026

Project Title

Multi-omics and pharmacoepidemiology to understand mechanisms of the dehydroxylation microbiome and clinical gallstone disease.

Grant Number:

1R01DK141277-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Our central hypothesis is that the intestinal Clostridium bacterial community of the human gut microbiome capable of 7𝛼-dehydroxylation conversion of primary to secondary bile acids is an underlying mechanism of clinical gallstone disease. Bacteria performing 7𝛼-dehydroxyl...

Research Terms

<0-11 years old><Abdomen><Affect><Analytic Chemistry><Analytical Chemistry><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Bacteria><Bile Acids><Bioinformatics><Biometrics><Biometry><Biostatistics><Blood Serum><C pylori><C. pylori><Campylobacter pylori><Cell Body><Cells><Child><Child Youth><Children (0-21)><Cholelithiasis><Clinical><Clinical Treatment><Clostridium><Cohort Studies><Colon><Computational Biology><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><DNA Molecular Biology><Data><Data Set><Development><Digestive Diseases><Digestive System Diseases><Digestive System Disorders><Disease><Disorder><Drug Exposure><Drugs><Electronic Health Record><Epidemiology><Excretory function><Exposure to><Functional Metagenomics><Future><GI microbiome><GI tract disorder><Gallbladder Calculus><Gallbladder Stone><Gallstones><Gastroduodenal Ulcer><Gene Expression><Gene Transcription><General Population><General Public><Generalized Growth><Genes><Genetic><Genetic Transcription><Genomics><Granulomatous Enteritis><Growth><H pylori><H pylory><H. pylori><H. pylory><Helicobacter pylori><Human><Human Microbiome><Incidence><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Interdisciplinary Research><Interdisciplinary Study><Intestinal><Intestines><Kidney Calculi><Kidney Stones><Knowledge><Link><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Medication><Metabolic><Metabolic Diseases><Metabolic Disorder><Metagenomics><Methodology><Methods><Mice><Mice Mammals><Miscellaneous Antibiotic><Modern Man><Molecular Biology><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Operative Procedures><Operative Surgical Procedures><Oral><Pain><Painful><Pathogenicity><Pathologic><Pathway interactions><Patients><Peptic Ulcer><Peptic Ulcer Disease><Pharmaceutical Epidemiology><Pharmaceutical Preparations><Pharmacoepidemiology><Play><Population><Prevalence><Prevention><Procedures><Production><RNA Expression><Renal Calculi><Renal Stone><Reporting><Research><Risk><Risk Reduction><Role><Route><Sampling><Secondary to><Serum><Small Intestines><Surgical><Surgical Interventions><Surgical Procedure><Techniques><Testing><Thesaurismosis><Tissue Growth><Transcript><Transcription><Ulcerated Colitis><Ulcerative Colitis><Urine><Vaccination><absorption><bacteria in the gut><bacterial community><bacterial disease treatment><bacterial infectious disease treatment><bile acid metabolism><bile metabolism><bowel><cholelith><clinical epidemiology><clinical intervention><clinical phenotype><clinical risk><clinical therapy><cohort research study><cohort survey><colon bacteria><colonic bacteria><computer biology><dehydroxylation><developmental><digestive disorder><digestive tract disease><digestive tract microbiome><disease prevention><disorder prevention><drug epidemiology><drug/agent><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><eleocolitis><enteric microbiome><epidemiologic><epidemiological><excretion><experience><experiment><experimental research><experimental study><experiments><exposed human population><fecal sample><gallstone disease><gastrointestinal microbiome><gastrointestinal tract disease><gastrointestinal tract disorder><gene function><gut bacteria><gut microbes><gut microbial species><gut microbiome><gut-associated microbiome><healthy volunteer><high risk><human exposure><human-associated microbiome><inducible expression><inducible gene expression><inflammatory disease of the intestine><inflammatory disorder of the intestine><intestinal autoinflammation><intestinal biome><intestinal microbes><intestinal microbiome><kids><metabolism disorder><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metagenome><metatranscriptome><metatranscriptomics><microbiome><multiomics><multiple omics><novel><ontogeny><panomics><pathway><patient oriented research><patient oriented study><pharmacoepidemiologic><pharmacoepidemiological><population based><prevent><preventing><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><regional enteritis><risk-reducing><skills><small bowel><social role><stool sample><stool specimen><surgery><surgery risk><surgical risk><therapeutic target><tool><trial regimen><trial treatment><youngster>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Carla Rose Nowosad

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$791,797
FY 2026

Project Title

Intestinal Programming of Gut-Associated Germinal Centers

Grant Number:

1R01AI190164-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/4/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY In the healthy intestine, the microbiota and intestinal immune system are intimately linked. One of the major regulators of the microbiome is the mucosal antibody, IgA, produced by intestinal B cells, which exerts unique immunomodulatory functions on bacterial communities. Failures i...

Research Terms

<7S Gamma Globulin><Address><Adherence><Affinity><Alleles><Allelomorphs><Anatomic Sites><Anatomic structures><Anatomy><Animals><Antibodies><Antibody Response><Antigens><Area><Assay><Autoimmune Status><Autoimmunity><Automobile Driving><Autoregulation><B blood cells><B cell><B cell receptor><B cells><B-Cell Activation><B-Cell Antigen Receptor><B-Cell Receptor Binding><B-Cells><B-Lymphocytes><B-cell><Bacteria><Behavior><Binding><Bioassay><Biological Assay><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Bp50><CD40><CDW40><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell model><Cells><Cellular model><Chimera><Chimera organism><Chronic><Class Switching><Class Switchings><Clonality><Clone Cells><Color><Communities><Coupled><Data><Disease><Disease Outcome><Disorder><Ecologic Systems><Ecological Systems><Ecosystem><Education><Educational aspects><Effectiveness><Environment><Evolution><Exposure to><Failure><Generations><Genetic><Germinal Center><Health><Homeostasis><Host Factor><Host Factor Protein><IgA><IgA FcR><IgA receptor><IgG><Image><Immune><Immune Regulators><Immune system><Immunes><Immunization><Immunoglobulin A><Immunoglobulin Class Switching><Immunoglobulin Class Switchings><Immunoglobulin G><Immunomodulation><Immunomodulators><Impairment><Infection><Infectious Diseases / Laboratory><Infectious Diseases Research><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Integration Host Factors><Intermediary Metabolism><Intestinal><Intestinal Diseases><Intestinal Disorder><Intestines><Intracellular Communication and Signaling><Isotype Switching><Isotype Switchings><Knowledge><Ligands><Link><Location><MGC9013><Malignant Neoplasms><Malignant Tumor><Maps><Measures><Membrane><Memory><Mental Depression><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Microanatomy><Microscopic Anatomy><Modeling><Molecular><Molecular Interaction><Mouse Strains><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Obesity><Physiologic><Physiological><Physiological Homeostasis><Production><Reaction><Receptor Activation><Receptor Signaling><Regulation><Research><Resolution><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Site><Specificity><Structure of germinal center of lymph node><TLR protein><TNFRSF5><TNFRSF5 gene><Tail><Testing><Therapeutic><Therapeutic Intervention><Thesaurismosis><Tissues><Toll-Like Receptor Family Gene><Toll-like receptors><Training><Transgenic Mice><Transgenic Organisms><Tumor Necrosis Factor Receptor Superfamily Member 5 Gene><activated B cells><adiposity><antigen binding><antigen bound><bacterial community><biological signal transduction><bowel><chimeras><commensal flora><commensal microbes><commensal microbiota><commensal microflora><corpulence><depression><desensitization><design><designing><driving><dysbacteriosis><dysbiosis><dysbiotic><fitness><flexibility><flexible><gut homeostasis><imaging><imaging approach><imaging based approach><imaging platform><immune microenvironment><immune modulation><immune modulators><immune regulation><immunogen><immunoglobulin A Fc receptor><immunoglobulin A receptor><immunologic reactivity control><immunological synapse formation><immunomodulatory><immunomodulatory molecules><immunoregulation><immunoregulator><immunoregulatory><immunoregulatory molecules><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><imprint><in vivo><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><interest><intervention therapy><intestinal autoinflammation><intestine disease><intestine disorder><malignancy><membrane structure><metabolism disorder><microbial><microbial composition><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microbiota composition><microflora><mouse model><multispecies consortia><murine model><neoplasm/cancer><novel><p50><pathogen><permissiveness><programs><receptor function><resolutions><response><social role><tool><transgenic><tumor immune microenvironment><tumor-immune system interactions>
View Full Project Details on NIH Reporter
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Andrew John Hryckowian

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$753,899
FY 2026

Project Title

The significant effects of butyrate on Clostridioides difficile fitness and pathogenesis

Grant Number:

1R01AI195616-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/2/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT The Centers for Disease Control and Prevention classifies Clostridioides difficile (Cd) as an urgent threat to the nation's health, as it causes 450,000 infections, 15,000 deaths, and 1 billion dollars in excess healthcare costs per year in the United States. The status quo ...

Research Terms

<Address><Affect><Alimentary Canal><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Applications Grants><Autolyses><Autolysis><Biology><Butyrates><C diff><C difficile><C. diff><C. difficile><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Cessation of life><Classification><Clostridioides difficile><Clostridium difficile><Collaborations><Complex><Coping Skills><DNA Molecular Biology><Data><Death><Development><Diarrhea><Diet><Dietary Fiber><Dietary Intervention><Digestive Tract><Disease><Disorder><Distal><Drug Targeting><Ecologic Systems><Ecological Systems><Ecosystem><Environment><Equilibrium><Exclusion><Exposure to><Fiber><Foundations><GI Tract><GI microbiome><Gastrointestinal Tract><Gastrointestinal tract structure><Generalized Growth><Gnotobiotic><Gnotobiotics><Goals><Grant Proposals><Growth><Health><Health Care Costs><Health Costs><Human><In Vitro><Individual><Infection><Inflammation><Intake><Intermediary Metabolism><Intracellular Communication and Signaling><Investigation><Life Style><Lifestyle><Mediating><Metabolic><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Microbe><Miscellaneous Antibiotic><Modern Man><Molecular Biology><Molecular Biology Techniques><Murine><Mus><Nutrition Interventions><Nutritional Interventions><Outcome><Pathogenesis><Population><Post-Translational Regulation><Posttranslational Regulation><Probiotics><Production><Proteomics><Recurrence><Recurrent><Replacement Therapy><Reproduction spores><Resistance><Resistance to antibiotics><Resistant to antibiotics><Ribo-seq><Risk><Risk Factors><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Spores><Systematics><Systems Biology><Testing><Therapeutic><Tissue Growth><Toxin><Transmission><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Virulence><Volatile Fatty Acids><Work><alimentary tract><antibiotic drug resistance><antibiotic resistant><bacterial genetics><balance><balance function><biological signal transduction><cell autolysis><cell culture><cell cultures><coping strategy><developmental><diet intervention><dietary manipulation><diets><digestive canal><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbiome><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><fitness><gastrointestinal><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><host microbiome><improved><intestinal biome><intestinal microbiome><metabolism measurement><metabolomics><metabonomics><microbial><microbial imbalance><microbiome><model of animal><mouse model><murine model><mutant><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><ontogeny><programs><resistant><response><ribosome footprint profiling><ribosome profiling><therapeutic target><transcriptomics><transmission process>
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Rosa Krajmalnik-Brown

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS, SCOTTSDALE, AZ

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$724,068
FY 2026

Project Title

Aflatoxin Exposure, Growth Faltering, and the Gut Microbiome among Children in Rural Guatemala

Grant Number:

5R01ES033999-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

10/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Aflatoxin B1 (AFB1) is a carcinogen produced by Aspergillus flavus and A. parasiticus which grow on maize. Given the high prevalence of stunting and other nutritional disorders in low- and middle-income countries where maize is highly consumed, the role of aflatoxin exposure is worth...

Research Terms

<0-11 years old><27E10 Antigen><Affect><Aflatoxin B1><Aflatoxins><Age Months><Albumins><Aspergillus flavus><Biologic Models><Biological><Biological Markers><Biological Models><Bioreactors><Biotransformation><Blood Serum><C-reactive protein><Calcium-Binding Myeloid Protein P8,14><Calgranulin><Calprotectin><Cancer Causing Agents><Carbohydrates><Carcinogens><Child><Child Health><Child Youth><Children (0-21)><Consumption><Country><Data><Diet><Dose><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Environmental Engineering technology><Epidemiology><Erythrocyte Sedimentation Rate><Exposure to><Functional Metagenomics><Funding><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Genomics><Growth><Guatemala><Harvest><Height><High Prevalence><High-Throughput DNA Sequencing><Human Microbiome><Hydrolysis><Indian Corn><Inflammation><Intermediary Metabolism><International><Investments><L1 Antigen><LMIC><Leukocyte L1 Antigen Complex><Leukocyte L1 Protein><Maize><Measurement><Measures><Mediating><Mediation><Metabolic Biotransformation><Metabolic Drug Detoxications><Metabolic Pathway><Metabolic Processes><Metabolism><Metabolism of Toxic Agents><Metagenomics><Migratory Inhibitory Factor-Related Protein MRP><Model System><Modeling><Molecular><Monitor><Myelomonocytic Antigen L1><NIEHS><National Institute of Environmental Health Sciences><Negotiating><Negotiation><Nutrient><Nutrition Disorders><Nutritional Disorders><Oncogens><Pathway interactions><Pediatrics><Physiologic><Physiological><Population><Prospective cohort><Proteins, specific or class, C-reactive><Public Health><Reporting><Ribosomal RNA Genes><Risk><Role><Rural><Science><Seasonal Cycle><Seasonal Variations><Seasons><Seminal><Serum><Short-Chain Fatty Acids><Starch><Structure><Time><Tissue Growth><Toxicology><USAID><Volatile Fatty Acids><Work><a. flavus><adduct><bio-markers><biologic><biologic marker><biomarker><bowel inflammation><community microbes><detoxification><dietary><diets><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><environmental engineering><epidemiologic><epidemiological><experiment><experimental research><experimental study><experiments><fecal microbiome><fecal sample><food preparation><full genome><gastrointestinal microbial flora><gastrointestinal microbiome><genome sequencing><gut community><gut flora><gut inflammation><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><health organization><human-associated microbiome><improved><inflamed bowel><inflamed gut><inflamed intestine><inflammation marker><inflammatory marker><innovate><innovation><innovative><interdisciplinary approach><intestinal biome><intestinal flora><intestinal inflammation><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kids><low and middle-income countries><microbe community><microbial><microbial community><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbioreactor><microorganism community><multidisciplinary approach><nutrient metabolism><oncogenic agent><ontogeny><pathway><polymicrobial community><prospective><rRNA Genes><remediation><response><social role><stool microbiome><stool sample><stool specimen><stool-associated microbiome><systemic inflammation><systemic inflammatory response><transcriptomics><whole genome><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Peter Rohloff

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS, SCOTTSDALE, AZ

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$724,068
FY 2026

Project Title

Aflatoxin Exposure, Growth Faltering, and the Gut Microbiome among Children in Rural Guatemala

Grant Number:

5R01ES033999-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

10/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Aflatoxin B1 (AFB1) is a carcinogen produced by Aspergillus flavus and A. parasiticus which grow on maize. Given the high prevalence of stunting and other nutritional disorders in low- and middle-income countries where maize is highly consumed, the role of aflatoxin exposure is worth...

Research Terms

<0-11 years old><27E10 Antigen><Affect><Aflatoxin B1><Aflatoxins><Age Months><Albumins><Aspergillus flavus><Biologic Models><Biological><Biological Markers><Biological Models><Bioreactors><Biotransformation><Blood Serum><C-reactive protein><Calcium-Binding Myeloid Protein P8,14><Calgranulin><Calprotectin><Cancer Causing Agents><Carbohydrates><Carcinogens><Child><Child Health><Child Youth><Children (0-21)><Consumption><Country><Data><Diet><Dose><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Environmental Engineering technology><Epidemiology><Erythrocyte Sedimentation Rate><Exposure to><Functional Metagenomics><Funding><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Genomics><Growth><Guatemala><Harvest><Height><High Prevalence><High-Throughput DNA Sequencing><Human Microbiome><Hydrolysis><Indian Corn><Inflammation><Intermediary Metabolism><International><Investments><L1 Antigen><LMIC><Leukocyte L1 Antigen Complex><Leukocyte L1 Protein><Maize><Measurement><Measures><Mediating><Mediation><Metabolic Biotransformation><Metabolic Drug Detoxications><Metabolic Pathway><Metabolic Processes><Metabolism><Metabolism of Toxic Agents><Metagenomics><Migratory Inhibitory Factor-Related Protein MRP><Model System><Modeling><Molecular><Monitor><Myelomonocytic Antigen L1><NIEHS><National Institute of Environmental Health Sciences><Negotiating><Negotiation><Nutrient><Nutrition Disorders><Nutritional Disorders><Oncogens><Pathway interactions><Pediatrics><Physiologic><Physiological><Population><Prospective cohort><Proteins, specific or class, C-reactive><Public Health><Reporting><Ribosomal RNA Genes><Risk><Role><Rural><Science><Seasonal Cycle><Seasonal Variations><Seasons><Seminal><Serum><Short-Chain Fatty Acids><Starch><Structure><Time><Tissue Growth><Toxicology><USAID><Volatile Fatty Acids><Work><a. flavus><adduct><bio-markers><biologic><biologic marker><biomarker><bowel inflammation><community microbes><detoxification><dietary><diets><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><environmental engineering><epidemiologic><epidemiological><experiment><experimental research><experimental study><experiments><fecal microbiome><fecal sample><food preparation><full genome><gastrointestinal microbial flora><gastrointestinal microbiome><genome sequencing><gut community><gut flora><gut inflammation><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><health organization><human-associated microbiome><improved><inflamed bowel><inflamed gut><inflamed intestine><inflammation marker><inflammatory marker><innovate><innovation><innovative><interdisciplinary approach><intestinal biome><intestinal flora><intestinal inflammation><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kids><low and middle-income countries><microbe community><microbial><microbial community><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbioreactor><microorganism community><multidisciplinary approach><nutrient metabolism><oncogenic agent><ontogeny><pathway><polymicrobial community><prospective><rRNA Genes><remediation><response><social role><stool microbiome><stool sample><stool specimen><stool-associated microbiome><systemic inflammation><systemic inflammatory response><transcriptomics><whole genome><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Lee Voth-Gaeddert

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS, SCOTTSDALE, AZ

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$724,068
FY 2026

Project Title

Aflatoxin Exposure, Growth Faltering, and the Gut Microbiome among Children in Rural Guatemala

Grant Number:

5R01ES033999-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

10/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Aflatoxin B1 (AFB1) is a carcinogen produced by Aspergillus flavus and A. parasiticus which grow on maize. Given the high prevalence of stunting and other nutritional disorders in low- and middle-income countries where maize is highly consumed, the role of aflatoxin exposure is worth...

Research Terms

<0-11 years old><27E10 Antigen><Affect><Aflatoxin B1><Aflatoxins><Age Months><Albumins><Aspergillus flavus><Biologic Models><Biological><Biological Markers><Biological Models><Bioreactors><Biotransformation><Blood Serum><C-reactive protein><Calcium-Binding Myeloid Protein P8,14><Calgranulin><Calprotectin><Cancer Causing Agents><Carbohydrates><Carcinogens><Child><Child Health><Child Youth><Children (0-21)><Consumption><Country><Data><Diet><Dose><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Environmental Engineering technology><Epidemiology><Erythrocyte Sedimentation Rate><Exposure to><Functional Metagenomics><Funding><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Genomics><Growth><Guatemala><Harvest><Height><High Prevalence><High-Throughput DNA Sequencing><Human Microbiome><Hydrolysis><Indian Corn><Inflammation><Intermediary Metabolism><International><Investments><L1 Antigen><LMIC><Leukocyte L1 Antigen Complex><Leukocyte L1 Protein><Maize><Measurement><Measures><Mediating><Mediation><Metabolic Biotransformation><Metabolic Drug Detoxications><Metabolic Pathway><Metabolic Processes><Metabolism><Metabolism of Toxic Agents><Metagenomics><Migratory Inhibitory Factor-Related Protein MRP><Model System><Modeling><Molecular><Monitor><Myelomonocytic Antigen L1><NIEHS><National Institute of Environmental Health Sciences><Negotiating><Negotiation><Nutrient><Nutrition Disorders><Nutritional Disorders><Oncogens><Pathway interactions><Pediatrics><Physiologic><Physiological><Population><Prospective cohort><Proteins, specific or class, C-reactive><Public Health><Reporting><Ribosomal RNA Genes><Risk><Role><Rural><Science><Seasonal Cycle><Seasonal Variations><Seasons><Seminal><Serum><Short-Chain Fatty Acids><Starch><Structure><Time><Tissue Growth><Toxicology><USAID><Volatile Fatty Acids><Work><a. flavus><adduct><bio-markers><biologic><biologic marker><biomarker><bowel inflammation><community microbes><detoxification><dietary><diets><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><environmental engineering><epidemiologic><epidemiological><experiment><experimental research><experimental study><experiments><fecal microbiome><fecal sample><food preparation><full genome><gastrointestinal microbial flora><gastrointestinal microbiome><genome sequencing><gut community><gut flora><gut inflammation><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><health organization><human-associated microbiome><improved><inflamed bowel><inflamed gut><inflamed intestine><inflammation marker><inflammatory marker><innovate><innovation><innovative><interdisciplinary approach><intestinal biome><intestinal flora><intestinal inflammation><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kids><low and middle-income countries><microbe community><microbial><microbial community><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbioreactor><microorganism community><multidisciplinary approach><nutrient metabolism><oncogenic agent><ontogeny><pathway><polymicrobial community><prospective><rRNA Genes><remediation><response><social role><stool microbiome><stool sample><stool specimen><stool-associated microbiome><systemic inflammation><systemic inflammatory response><transcriptomics><whole genome><youngster>
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Michael A Silverman

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$721,401
FY 2026

Project Title

Leveraging early-life microbes to prevent type 1 diabetes

Grant Number:

5R01DK133453-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Type 1 diabetes (T1D) is an autoimmune disease that affects millions of people worldwide. The incidence of T1D is rising, especially in young children. Although significant progress has been made to predict who is at risk for developing T1D, there are no effective therapies to preven...

Research Terms

<0-11 years old><21+ years old><Adult><Adult Human><Affect><Alleles><Allelomorphs><Anatomic Sites><Anatomic structures><Anatomy><Antigen Presentation><Antigens><Autoantigens><Autoimmune Diabetes><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Autologous Antigens><Bacteria><Birth><Brittle Diabetes Mellitus><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Child><Child Youth><Childhood><Children (0-21)><Class II Antigens><Class II Major Histocompatibility Antigens><Communities><Complex><Data><Development><Diabetes Mellitus><Disease><Disorder><Environmental Factor><Environmental Risk Factor><Exposure to><GI microbiome><Generalized Growth><Genetic><Genetic Models><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><Growth><HL-A Antigens><HLA Antigens><Haplotypes><Histocompatibility Antigens Class II><Histocompatibility Complex><Histocompatibility Complices><Human><Human Leukocyte Antigens><I-A Antigen><IDDM><Ia Antigens><Ia-Like Antigens><Immune><Immune Response Antigens><Immune response><Immune system><Immune-Response-Associated Antigens><Immunes><Immunization><Immunomodulation><In Vitro><Inbred NOD Mice><Incidence><Insulin-Dependent Diabetes Mellitus><Intestinal><Intestines><Investigation><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Knowledge><Leukocyte Antigens><Life><MHC Class II Molecule><MHC Class II Protein><MHC class II antigen><Major Histocompatibility Complex><Major Histocompatibility Complex Class II><Major Histocompatibility Complices><Mediating><Metabolic><Mice><Mice Mammals><Microbe><Modeling><Modern Man><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><NOD Mouse><Non-Obese Diabetic Mice><Nonobese Diabetic Mouse><Parturition><Pathway interactions><Peptides><Peripheral><Persons><Phylogenetic Analysis><Phylogenetics><Predisposition><Property><Proteins><Publishing><Regulatory T-Lymphocyte><Research><Risk><Role><Self-Antigens><Shapes><Site><Sudden-Onset Diabetes Mellitus><Susceptibility><System><Systems Development><T cell receptor repertoire sequencing><T cell receptor sequencing><T cell response><T-Cells><T-Lymphocyte><T1 DM><T1 diabetes><T1D><T1DM><T4 Cells><T4 Lymphocytes><TCR repertoire sequencing><TCR sequencing><TCR-seq><TCRseq><Testing><Therapeutic><Time><Tissue Growth><Transgenic Mice><Transgenic Organisms><Transmission><Treg><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Weaning><Work><adulthood><autoimmune beta cell destruction><autoimmune condition><autoimmune disorder><autoimmune islet destruction><autoimmunity disease><beta cell autoimmunity><bowel><community microbes><developmental><diabetes><diabetes pathogenesis><digestive tract microbiome><early life exposure><effective therapy><effective treatment><enteric microbiome><environmental risk><gastrointestinal homeostasis><gastrointestinal microbiome><genetic linkage><gut microbes><gut microbial species><gut microbiome><gut-associated microbiome><host microbiota><host microflora><host response><imaging mass spectrometry><immune modulation><immune regulation><immune system response><immunogen><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><in vivo><innovate><innovation><innovative><insight><insulin dependent diabetes><insulin dependent type 1><intestinal biome><intestinal homeostasis><intestinal microbes><intestinal microbiome><islet autoimmunity><islet cell autoimmunity><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><kids><mass spectrometric imaging><member><metabolism measurement><metabolomics><metabonomics><microbe community><microbial><microbial antigen><microbial community><microbial consortia><microbial flora><microbial interaction><microbial products><microbiome><microbiota><microflora><microorganism antigen><microorganism community><microorganism interaction><mouse model><multispecies consortia><murine model><non-obese diabetic (NOD) mice><nonobese diabetic (NOD) mice><ontogeny><pathway><pediatric><polymicrobial community><prevent><preventing><protective effect><rational design><regulatory T-cells><resident microbes><resident microflora><response><restraint><social role><spatial temporal imaging><spatial temporal mapping><spatiotemporal imaging><spatiotemporal mapping><thymus derived lymphocyte><tool><transgenic><transmission process><type I diabetes><type one diabetes><validation studies><youngster>
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Amy Boriskie Hair

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$709,040
FY 2026

Project Title

Liver-Gut-Microbiome Axis and Fatty acid absorption in Preterm Infants

Grant Number:

5R01DK135602-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/16/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Current nutritional strategies fail to meet the needs of very low birth weight infants, with more than half developing malnutrition, growth failure, and other poor outcomes. Long Chain Polyunsaturated Fatty Acids (LCPUFAs) are vital for brain and retinal development, immune ...

Research Terms

<3rd trimester><Address><Age><Animals><Autoregulation><Bile Acid Biosynthesis><Bile Acid Biosynthesis Pathway><Bile Acids><Bile Duct Obstruction><Biliary Stasis><Bioavailability><Biological Availability><Birth><Blood><Blood Reticuloendothelial System><Blood Serum><Brain><Brain Nervous System><Breast Milk><Breastmilk><Cells Placenta-Tissue><Cellular Immune Function><Characteristics><Cholestasis><Chronic lung disease><Clinical><Clinical Nutrition><Coupled><Development><Diet><Dietary Fatty Acid><Dietary intake><Digestion><Early Intervention><Encephalon><Enteral><Enteric><Enzyme Gene><Enzymes><Failure><Fats><Fatty Acids><Fatty acid glycerol esters><Feces><Future><GC MS><GCMS><GI microbiome><GI microbiota><Gas-Liquid-Mass Spectrometry Chromatography><Gastrointestinal microbiota><Gene Copy Number><Gene Dosage><Generalized Growth><Genes><Growth><Health><Health Benefit><Homeostasis><Hour><Human Milk><Human Mother's Milk><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><Immunologic Factors><Immunological Factors><Impairment><In Vitro><Individual><Infant><Inflammatory><Infrastructure><Intestinal><Intestinal Absorption><Intestines><Knowledge><Last Trimester><Life><Linear Models><Link><Lipase><Lipids><Liver><Malabsorption Syndromes><Malnutrition><Mammary Gland Milk><Mass Fragmentographies><Mass Fragmentography><Mass-Gas Chromatography Spectrometry><Mass-Gas Chromatography Spectrum Analysis><Measures><Metabolic Pathway><Microbe><Modeling><Morbidity><Mother's Milk><Necrotizing Enterocolitis><Neonatal><Normal Placentoma><Nutrient><Nutrition><Nutritional><Nutritional Deficiency><Outcome><Parturition><Pathogenesis><Physiologic Availability><Physiological Homeostasis><Physiology><Placenta><Placenta Embryonic Tissue><Placentome><Polyunsaturated Fatty Acids><Population><Premature Birth><Premature Infant><Prematurely delivering><Preterm Birth><Regulation><Retina><Retinopathy of Prematurity><Retrolental Fibroplasia><Risk><Sepsis><Serum><Shapes><Shotgun Sequencing><Technology><Third Pregnancy Trimester><Third Trimester><Time><Tissue Growth><Triacylglycerol Hydrolase><Triacylglycerol Lipase><Triacylglycerol acylhydrolase><Tributyrinase><Triglyceridase><Triglyceride Lipase><Triolean Hydrolase><Undernutrition><VLBW><Very Low Birth Weight Infant><Weight Gain><Weight Increase><absorption><ages><analytical tool><bacteria in the gut><bile acid anabolism><bile acid biosynthetic process><bile acid formation><bile acid metabolism><bile acid synthesis><bile metabolism><bile obstruction><bile occlusion><bile salts><body weight gain><body weight increase><bowel><cholestatic diseases><cholestatic disorder><cholestatic liver disease><cholestatic liver disorder><cholestatic syndromes><chronic pulmonary disease><cohort><developmental><dietary deficiency><diets><digestive tract microbiome><donor milk><effective intervention><enteric microbial community><enteric microbiome><enteric microbiota><enzyme activity><experience><gastrointestinal absorption><gastrointestinal absorption disorder><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hepatic body system><hepatic organ system><high risk><immune function><immunologic substance><immunological substance><improved><infancy><infant outcome><infantile><infants born premature><infants born prematurely><intestinal biome><intestinal flora><intestinal malabsorption><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><ion trap mass spectrometry><long chain fatty acid><malabsorption><malnourished><mass fragmentometry><maternal milk><metagenome><microbial><mortality><neonatal care><neonatal morbidity><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><newborn morbidity><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><nutrition deficiency><nutrition deficiency disorder><nutritional deficiency disorder><nutritious><ontogeny><pasteurization><placental transfer><postnatal><premature><premature baby><premature childbirth><premature delivery><premature infant human><premature retinopathy><prematurity><preterm baby><preterm delivery><preterm infant><preterm infant human><prospective><recruit><stool><therapeutic target><tributyrase><uptake><very low birth weight><wt gain>
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John Patrick Haran

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$703,465
FY 2026

Project Title

Understanding the Microbiome-gut-brain axis in Alzheimers disease and its Role

Grant Number:

2R01AG067483-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2020

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT The gut microbiome is emerging as a possible causative trigger for disease progression in Alzheimer's disease (AD) via systemic immune dysfunction. While full progression to clinical disease is complex and multifactorial, our ongoing work points to a novel microbiome-gut-brain axis associat...

Research Terms

<21+ years old><AD brain><AD dementia><AD pathology><AD patients><AD prevention><AD risk><AD risk factor><AD transgenic mice><Adult><Adult Human><Affect><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease prevention><Alzheimer prevention><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease risk><Alzheimer's disease transgenic mice><Alzheimer's pathology><Alzheimer's patient><Alzheimer's transgenic mice><Alzheimers Dementia><Amentia><Automobile Driving><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Cellular Immune Function><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Complex><Data><Dementia><Development><Disease><Disease Progression><Disorder><Disturbance in cognition><Dysfunction><Feces><Functional disorder><Funding><Future><GI microbiome><Goals><Grant><Human><IQ Deficit><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunes><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Impaired cognition><Inflammation><Investigation><Investigators><Lead><Long-term cohort><Longitudinal cohort><Mediating><Methionine><Methionine Metabolism><Methionine Metabolism Pathway><Microbiomics><Modern Man><Neurocognitive><Neurocognitive Deficit><Neurologic Dysfunctions><Pathologic><Pathway interactions><Patients><Pb element><Peripheral><Phenotype><Physiopathology><Prevention><Primary Senile Degenerative Dementia><Process><Production><Research><Research Personnel><Researchers><Risk><Role><Sampling><Study Subject><Symptoms><T-Cells><T-Lymphocyte><Time><Transgenic Organisms><Transplantation><Vulnerable Populations><Work><abnormal brain function><absorption><adulthood><ages><alzheimer risk><brain dysfunction><brain impairment><cognitive change><cognitive dysfunction><cognitive loss><cohort><cohort investigation><cohort research><deep sequencing><developmental><diet control><dietary control><digestive tract microbiome><driving><dysbacteriosis><dysbiosis><dysbiotic><dysfunctional brain><enteric microbiome><fecal sample><gastrointestinal microbiome><gut microbes><gut microbial species><gut microbiome><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><heavy metal Pb><heavy metal lead><immune function><immune senescence><immunopathology><immunosenescence><intelligence quotient deficit><intestinal biome><intestinal epithelium><intestinal microbes><intestinal microbiome><investigate cohort><metabolism measurement><metabolomics><metabonomics><microbial imbalance><microbiome><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><mouse model><murine model><neural><neural inflammation><neurocognitive decline><neurocognitive impairment><neuroinflammation><neuroinflammatory><neurological dysfunction><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><older adult><older adulthood><pathophysiology><pathway><patient living with Alzheimer's disease><patient population><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><primary degenerative dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><scRNA sequencing><scRNA-seq><senescence and its associated secretory phenotype><senescence associated secretome><senescence associated secretory factors><senescence associated secretory pathway><senescence associated secretory phenotype><senescence associated secretory program><senescence associated secretory proteins><senescent associated secretome><senescent associated secretory phenotype><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stool><stool sample><stool specimen><study cohort><success><survey cohort><synergism><thymus derived lymphocyte><transgenic><transgenic AD model><transgenic Alzheimer's model><transgenic model of alzheimer disease><transplant><vulnerable group><vulnerable individual><vulnerable people>
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Cindy Liu

GEORGE WASHINGTON UNIVERSITY, WASHINGTON, DC

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$686,339
FY 2026

Project Title

Influence of the nasal microbiome on host susceptibility and response to respiratory viruses

Grant Number:

5R01AI168182-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/17/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The nasal cavity has a unique microbiome, which is expected to significantly affect local immune response and in turn, susceptibility of the host to respiratory viruses. However, we know little about these potential host- microbe interactions. Our long-term goal is to elucidate how m...

Research Terms

<0-11 years old><2019 novel corona virus><2019 novel coronavirus><2019-nCoV><21+ years old><Acute><Address><Adult><Adult Human><Affect><Airway infections><Autoregulation><Bacteria><CAIV-T><COVID-19 virus><COVID19 virus><Child><Child Youth><Children (0-21)><Chronic><Co-culture><CoV-2><CoV2><Cocultivation><Coculture><Coculture Techniques><Communicable Diseases><Communities><Coronaviridae><Coronavirus><Disease><Disorder><Environment><Epidemiology><Epithelium><FluMist><Goals><Grippe><Home><Homeostasis><IFN><Immune><Immune response><Immunes><Immunology><In Vitro><Infant><Infectious Diseases><Infectious Diseases / Laboratory><Infectious Diseases Research><Infectious Disorder><Inflammation><Inflammatory><Influenza><Influenza A><Influenza A virus><Influenza Viruses Type A><Influenzavirus A><Interferons><Knowledge><Longitudinal Studies><Longitudinal Surveys><Lower respiratory tract structure><Mission><Modeling><Mucosa><Mucosal Tissue><Mucous Membrane><Mucous body substance><Mucus><NIH><Nasal><Nasal Passages Nose><Nasal cavity><National Institutes of Health><Nose><Orthocoronavirinae><Orthomyxovirus Type A><Outcome><Physiological Homeostasis><Population><Predisposition><Property><Public Health><Pulmonary Body System><Pulmonary Organ System><Research><Respiratory Epithelium><Respiratory Infections><Respiratory System><Respiratory System, Nose, Nasal Passages><Respiratory Tract Infections><Respiratory Tracts><Respiratory tract structure><Rest><Rhinovirus><Risk><Risk Reduction><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sampling><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Structure of respiratory epithelium><Susceptibility><Testing><Time><Type A Influenza><United States National Institutes of Health><Upper respiratory tract><Vaccination><Variant><Variation><Viral><Viral Diseases><Viral Respiratory Tract Infection><Virus><Virus Diseases><Virus Replication><Work><Wuhan coronavirus><adulthood><airway epithelium><airway microbiome><corona virus><coronavirus disease 2019 virus><coronavirus disease-19 virus><cytokine><disease risk><disorder risk><epidemiologic><epidemiological><experiment><experimental research><experimental study><experiments><hCoV19><homes><host microbe association><host microbe relationship><host response><host-microbe interactions><host-microbial interactions><host-microorganism interactions><immune system response><immunoresponse><improved><innovate><innovation><innovative><kids><long-term study><longitudinal outcome studies><longitudinal research study><lower respiratory tract><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><mucous><nCoV2><nasal microbiome><new approaches><novel approaches><novel strategies><novel strategy><prevent><preventing><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><respiratory microbiome><respiratory tract epithelium><respiratory tract microbiome><respiratory virus><response><risk-reducing><sinonasal microbiome><upper airway tract><viral infection><viral multiplication><viral replication><viral respiratory infection><virology><virus infection><virus multiplication><virus-induced disease><youngster>
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CHARLES SFEIR

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$679,631
FY 2026

Project Title

Treatment for Peri-implantitis via Local Immunomodulation and Effect on the Microbiome

Grant Number:

1R01DE034994-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Each year roughly 500,000 implants are placed in the United States. Of these 500,000 implants approximately 5-10% fail due to a variety of complications, the most common one being peri-implantitis (PI). PI is considered an oral inflammatory condition where accumulation of bacteria on the implant sur...

Research Terms

<A-152E5.1><ABCD-1><Affect><Alveolar Bone Loss><Alveolar Resorption><Animals><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibodies><Autoregulation><Bacteria><Biological><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Body Tissues><Bone Resorption><Buccal Cavity><Buccal Cavity Head and Neck><CCL2><CCL2 gene><CCL22><CCL22 gene><Cavitas Oris><Cell Body><Cells><Chemokine, CC Motif, Ligand 2><Chemotactic Cytokines><Chronic Periodontitis><Clinical Treatment><DC/B-CK><Data><Dental Implants><Development><Disease><Disease Progression><Disorder><Drug Delivery><Drug Delivery Systems><Engineering><Exhibits><Failure><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Frequencies><Functional Metagenomics><Grant><Gum Disease><Healing abnormal><Healing delayed><Health><Homeostasis><Homologous Chemotactic Cytokines><Human><Immune><Immune Modulation Therapy><Immune infiltrates><Immune response><Immune system><Immunes><Immunomodulation><Impaired healing><Implant><Inflammation><Inflammatory><Innate Immune Response><Intercrines><KO mice><Knock-out Mice><Knockout Mice><Ligature><Link><Literature><MCAF><MCP-1><MCP1><MGC34554><Macrophage><Marrow Neutrophil><Mediating><Metagenomics><Methods><Mice><Mice Mammals><Microbial Biofilms><Modeling><Modern Man><Monocyte Chemoattractant Protein-1><Monocyte Chemotactic Protein-1><Monocyte Chemotactic and Activating Factor><Monocyte Chemotactic and Activating Protein><Monocyte Chemotactive and Activating Factor><Monocyte Secretory Protein JE><Mouth><Mouth microbiome><Murine><Mus><Mφ><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Null Mouse><Oral><Oral cavity><Osteoclastic Bone Loss><Parodontosis><Pathogenesis><Periodontal Bone Loss><Periodontal Diseases><Periodontal Resorption><Periodontitis><Phenotype><Physiological Homeostasis><Play><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Process><Proteins><Public Health><Regulatory T-Lymphocyte><Resolution><Role><SCYA2><SCYA22><SIS cytokines><STCP-1><Small Inducible Cytokine A2><Surface><T-Cells><T-Lymphocyte><Testing><Therapeutic><Tissues><Tooth><Tooth structure><Translating><Treg><United States><Work><X-ray microtomography><Xray microtomography><anti-microbial><antimicrobial><biodegradable polymer><biofilm><biologic><bioresorbable polymer><bone loss><chemoattractant cytokine><chemokine><chronic inflammatory disease><clinical intervention><clinical therapy><cytokine><degradable polymer><developmental><dysbacteriosis><dysbiosis><dysbiotic><experiment><experimental research><experimental study><experiments><flow cytophotometry><host response><immune cell infiltrate><immune modulation><immune modulatory therapies><immune modulatory treatment><immune regulation><immune regulation therapy><immune regulation treatment><immune regulatory therapy><immune system response><immune-modulation treatment><immunologic reactivity control><immunomodulation therapy><immunomodulation treatment><immunomodulator therapies><immunomodulator treatment><immunomodulator-based therapies><immunomodulatory><immunomodulatory biologics><immunomodulatory therapies><immunomodulatory treatment><immunoregulation><immunoregulatory><immunoregulatory therapy><immunoregulatory treatment><immunoresponse><inflammatory environment><inflammatory milieu><insight><local drug delivery><micro CT><micro computed tomography><microCT><microbial imbalance><microbiome><microtomography><mouse model><murine model><neutrophil><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><oral microbiome><particle><peri-implantitis><periimplantitis><periodontal disorder><periodontium disease><periodontium disorder><prevent><preventing><recruit><regulatory T-cells><repair><repaired><resolutions><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><soft tissue><standard of care><teeth><therapeutic immunomodulation><therapeutic immunoregulation><thymus derived lymphocyte><tool><trial regimen><trial treatment>
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Mark Lockwood

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$666,762
FY 2026

Project Title

The Gut Microbiome and Serum Metabolites as a Biological Mechanism Underlying Pain in Kidney Transplantation (Biome-KT)

Grant Number:

5R01DK135574-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

7. Abstract Nearly half (47%) of people with end-stage kidney disease (ESKD) whose kidney function is restored after kidney transplantation experience chronic pain compared to 19% of adults in the US general population. Pain is associated with comorbid fatigue, depression and anxiety, and withdrawal...

Research Terms

<2,3-Pyridinedicarboxylic acid><21+ years old><3-indolylacetic acid><5-HT><5-Hydroxytryptamine><5HT><Address><Adult><Adult Human><Affect><Age><Alimentary Canal><Anxiety><Bacteria><Biological><Biological Markers><Blood Serum><Brain><Brain Nervous System><Carbamide><Catabolism><Chemicals><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Cognitive><Communities><Consumption><Data><Diet><Dietary Practices><Digestive Tract><Disease><Disorder><ESKD><ESRD><Economic Income><Economical Income><Elaqua XX><Emotional><Encephalon><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Endocrine><Endotoxins><Enteramine><Enterococcus><Environmental Factor><Environmental Risk Factor><Fatigue><Fats><Fatty acid glycerol esters><Feces><Fiber><Foundations><GI Tract><GI microbiome><GI microbiota><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><General Population><General Public><Generalized Growth><Genes><Goals><Growth><Hemodialyses><Hemodialysis><Hippophaine><Human Figure><Human body><IES cpd><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Impairment><Income><Indoles><Inflammation><Intervention><Intestinal><Intestines><Investigation><Kidney><Kidney Diseases><Kidney Grafting><Kidney Transplantation><Kidney Transplants><Kidney Urinary System><Kynurenic Acid><Kynurenine><L-Tryptophan><Lack of Energy><Levotryptophan><Life><Link><Measures><Mediating><Mental Depression><Metabolic><Microbe><Modeling><Nephropathy><Neuropathy><Nociception><Pain><Pain Control><Pain Therapy><Pain intensity><Pain interference><Pain management><Painful><Pathway interactions><Patient Self-Report><Persons><Phenotype><Play><Probiotics><Psychologic Stress><Psychological Stress><Quinolinic Acid><Race><Races><Recreation><Renal Disease><Renal Grafting><Renal Transplantation><Renal Transplants><Renal function><Reporting><Risk><Role><Self-Report><Serotonin><Serum><Short-Chain Fatty Acids><Signaling Molecule><Streptococcus enterococcus group><Stress><Supplementation><Testing><Time><Tissue Growth><Toxin><Transplant Recipients><Transplantation><Treatment Protocols><Treatment Regimen><Treatment Schedule><Tryptophan><Urea><Urea Carbamide><Ureaphil><Volatile Fatty Acids><Withdrawal><adulthood><ages><alimentary tract><beta diversity><beta-indoleacetic acid><bio-markers><biologic><biologic marker><biomarker><bowel><chemical reduction><chronic kidney disease><chronic pain><co-morbid><co-morbidity><community microbes><comorbidity><daily functioning><depression><design><designing><dietary pattern><diets><digestive canal><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><experience><food Ingestion><food consumption><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><health related quality of life><host microbe association><host microbe relationship><host-microbe interactions><host-microbial interactions><host-microorganism interactions><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved><incomes><indexing><indole acetic acid><indole-3-acetic acid><indoleacetic acid><indolyl-3-acetic acid><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><investigate longitudinal><kidney disorder><kidney function><kidney tx><longitudinal investigation><longitudinal research><machine learned algorithm><machine learning algorithm><machine learning based algorithm><machine learning based model><machine learning model><microbe community><microbial><microbial community><microbial composition><microbial consortia><microbial flora><microbiome><microbiota><microbiota community><microflora><microorganism><microorganism community><mortality><multi-modality><multimodality><multispecies consortia><neuropathic><neuropathic pain><neurotoxic><nociceptive><novel><ontogeny><pain intervention><pain reduction><pain relief><pain score><pain treatment><painful neuropathy><pathway><patient centered><patient oriented><patient population><perceived stress><perception of stress><polymicrobial community><post-transplant><post-transplantation><posttransplant><posttransplantation><prebiotics><prevent><preventing><prospective><racial><racial background><racial origin><reduce pain><relieve pain><renal><renal disorder><restoration><self-reported stress><social><social role><stool><stress perception><stress reduction><study longitudinal><sugar><survey longitudinal><systemic inflammation><systemic inflammatory response><therapy optimization><transplant><transplant model><transplant patient><treatment adherence><treatment compliance><treatment optimization>
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Allison Sylvetsky

GEORGE WASHINGTON UNIVERSITY, WASHINGTON, DC

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$662,577
FY 2026

Project Title

Effects of a non-nutritive sweetener reduction intervention in pregnancy and lactation on maternal and infant outcomes (the SWEETPEA trial)

Grant Number:

5R01HD107427-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Increasing evidence demonstrates that suboptimal conditions in the womb, including poor maternal nutrition, contributes to obesity and cardiometabolic disease risk. One potential contributor to poor maternal nutrition is chronic consumption of non-nutritive sweeteners (NNS). Studies indicat...

Research Terms

<21+ years old><Adherence><Adult><Adult Human><Affect><Age Months><Air><Automobile Driving><BMI><BMI percentile><BMI z-score><Beverages><Blood Glucose><Blood Sugar><Body Composition><Body fat><Body mass index><Breast Milk><Breastmilk><Cardiometabolic Disease><Cardiometabolic Disorder><Childhood><Chronic><Cohort Studies><Consultations><Consumption><Control Groups><Counseling><Data><Development><Dietitian><Disease><Disorder><Ethics><Exclusive Breastfeeding><Exposure to><Fats><Fatty acid glycerol esters><Feces><Food><Functional Metagenomics><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Gestation><Gestational Diabetes><Gestational Diabetes Mellitus><Glucose Intolerance><Growth><Guidelines><Health><Home><Hour><Human><Human Characteristics><Human Milk><Human Mother's Milk><Human Nature><Hypoglycemia><Infant><Infant Health><Inflammation><Inflammatory><Intake><Intervention><Lactation><Leanness><Life><Mammary Gland Milk><Maternal Health><Maternal Nutrition><Maternal diet><Measures><Metabolic><Metagenomics><Mice><Mice Mammals><Microbe><Modern Man><Mother's Milk><Mothers><Murine><Mus><OGTT><Obesity><Observational Study><Oral Glucose Tolerance Test><Outcome><Pathway interactions><Physiologic><Physiological><Plethysmography><Postpartum Period><Pregnancy><Pregnancy-Induced Diabetes><Pregnant Women><Prospective, cohort study><Quetelet index><Randomized><Randomized, Controlled Trials><Recommendation><Reporting><Research><Risk Factors><Rodent><Rodent Model><Rodentia><Rodents Mammals><Safety><Shapes><Solid><Sweeteners><Sweetening Agents><Thinness><Tissue Growth><Toxicology><Transmission><United States><Urine><Uterus><Weight><Woman><adiposity><adulthood><blood glucose regulation><cardiometabolic risk><cohort research study><cohort survey><consultation><corpulence><developmental><diabetes risk><dietary><digestive tract microbiome><disease risk><disorder risk><dosage><driving><early life exposure><enteric microbial community><enteric microbiome><enteric microbiota><ethical><expectant mother><expectant women><expecting mother><expecting women><exposed in utero><fetal><fetal exposure><gastrointestinal microbial flora><gastrointestinal microbiome><glucose control><glucose homeostasis><glucose regulation><glucose tolerance><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiome of infant><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><homes><hypoglycemic><hypoglycemic episodes><improved><in utero><in utero exposure><individuals who are pregnant><infant adiposity><infant gut microbiome><infant obesity><infant outcome><infantile obesity><insulin sensitivity><intergenerational><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intra-uterine environmental exposure><intrauterine environmental exposure><lactating><lactational><maternal milk><maternal nutrition during pregnancy><maternal outcome><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><mother nutrition><mother outcome><neonate gut microbiome><newborn gut microbiome><obesity among infants><obesity in infants><observational research study><observational survey><offspring><offspring obesity><ontogeny><pathway><pediatric><people who are pregnant><post-partum><postnatal><pregnancy diabetes><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prenatal exposure><prenatally exposed><randomisation><randomization><randomized control trial><randomly assigned><recruit><stool><those who are pregnant><transmission process><unborn><weights><womb><women who are pregnant>
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Michiko E. Taga

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$612,216
FY 2026

Project Title

Microbial Corrinoid Metabolism Across Scales: From Molecular Specificity to Community Dynamics

Grant Number:

2R35GM139633-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2021

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Microbial communities are ubiquitous on earth, inhabiting nearly every niche in the environment and on the human body. The composition and metabolic activities of the human microbiome are known to impact health. However, much remains unknown about how these communities assem...

Research Terms

<Address><Communities><Complex><Corrinoids><Cyanocobalamin><Development><Earth><Environment><Enzyme Gene><Enzymes><Family><GI microbiome><Genes><Health><Human><Human Activities><Human Figure><Human Microbiome><Human body><Individual><Intermediary Metabolism><Knowledge><Laboratories><Metabolic><Metabolic Processes><Metabolism><Microbe><Modeling><Modern Man><Molecular><Nature><Nutrient><Planet Earth><Soil><Specificity><Structure><VIT B12><Vitamin B 12><Vitamin B12><Work><bacteria in the gut><cofactor><community microbes><design><designing><develop therapy><developmental><digestive tract microbiome><enteric microbiome><gastrointestinal microbiome><genomic predictors><gut bacteria><gut microbiome><gut-associated microbiome><human-associated microbiome><improved><intervention development><intestinal biome><intestinal microbiome><microbe community><microbial><microbial community><microbial composition><microbial consortia><microbial flora><microbial interaction><microbiome><microbiota><microflora><microorganism community><microorganism interaction><multispecies consortia><polymicrobial community><preference><therapy development><treatment development>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Cindy Liu

GEORGE WASHINGTON UNIVERSITY, WASHINGTON, DC

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$599,890
FY 2026

Project Title

How sex, host microenvironment, and immune responses shape acquisition of genital bacteria that increase HIV risk

Grant Number:

5R01DK131936-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2021

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Recently, several genital anaerobic bacteria that are not classically associated with sexually transmitted infections (non-STI) were linked to increased heterosexual transmission of HIV, likely by inducing immune responses that enhances HIV target cell activation and recruitment to t...

Research Terms

<AIDS Virus><AIDS prevention><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adjuvant><Affect><After Care><After-Treatment><Aftercare><Anaerobic Bacteria><Automobile Driving><Bacteria><Biological><Cell Body><Cells><Chlolincocin><Chlorlincocin><Circumcision><Clindamycin><Co-culture><Cocultivation><Coculture><Coculture Techniques><Coitus><Communicable Diseases><Couples><Development><Epidemiologic analysis><Flagyl><Foreskin><Functional Metagenomics><Genital Organs><Genitalia><Goals><H2O2><HIV><HIV Prevention><HIV disease transmission><HIV infection spread><HIV infection transmission><HIV risk><HIV spread><HIV transmission><HIV viral transmission><HIV-1 prevention><HIV-1 spread><HIV-1 transmission><HIV-1 virus transmission><HIV/AIDS prevention><HIV/AIDS transmission><Heterosexuals><Hour><Human Immunodeficiency Virus Type 1 transmission><Human Immunodeficiency Viruses><Hydrogen Peroxide><Hydroperoxide><IgA><Immune><Immune response><Immunes><Immunoglobulin A><Individual><Infectious Diseases><Infectious Disorder><Intervention Studies><Knowledge><LAV-HTLV-III><Link><Lymphadenopathy-Associated Virus><Male Adolescents><Male Prepuce><Metagenomics><Metronidazole><Mission><Modeling><Mucosa><Mucosal Immune Responses><Mucosal Tissue><Mucous Membrane><NIH><National Institutes of Health><O element><O2 element><Observational Study><Oral><Outcome><Oxygen><Predisposition><Preputium Penis><Prevent HIV><Preventative strategy><Prevention strategy><Preventive strategy><Public Health><Reproducibility><Research><Research Design><Risk Factors><Satric><Sexual Intercourse><Sexual Transmission><Sexually Transmitted Diseases><Sexually Transmitted Disorder><Sexually Transmitted Infection><Shapes><Study Type><Susceptibility><Testing><Tinidazole><Topical Drug Administration><Topical application><Transmission><Treatment outcome><United States National Institutes of Health><Vagina><Venereal Diseases><Venereal Disorders><Venereal Infections><Viral><Virus-HIV><Woman><Work><adolescent boy><anaerobe><anti-microbial><antimicrobial><apply topically><arm><biologic><deliver topically><density><design><designing><developmental><driving><dysbacteriosis><dysbiosis><dysbiotic><epidemiologic evaluation><fighting><genital microbiome><host response><human immunodeficiency virus transmission><immune system response><immunoresponse><in vitro Model><initiation of sexual activity><innovate><innovation><innovative><intervention arm><intervention research><interventional research><interventional study><interventions research><men><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><novel><observational research study><observational survey><outcome prediction><pandemic><pandemic disease><penile microbiome><penis><penis foreskin><poor health outcome><post treatment><prevent><prevent AIDS><prevent human immunodeficiency virus><preventing><recruit><reduced health outcome><response><sex><sexual debut><sexual initiation><sexually acquired infection><sexually transmitted><spread of human immunodeficiency virus><study design><topical administration><topical anti-microbial><topical delivery><topical drug application><topical drug delivery><topical instillation><topical treatment><transmission process><treat topically><treatment arm><vaginal biome><vaginal microbiome><worse health outcome>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Robert S B Clark

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$586,588
FY 2026

Project Title

Impact of microbiota-derived metabolites on traumatic brain injury-related neurodegeneration

Grant Number:

5R01NS127372-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Traumatic brain injury (TBI)-related neurodegeneration (TReND) is increasingly recognized as a major health concern and cause of cognitive decline. Neuroinflammation, a proposed mechanism of TReND, may persist for years after the primary injury. We propose that chronic intestinal dysbiosis after TBI...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><21+ years old><Acceleration><Acetates><Acetylation><Active Follow-up><Address><Adult><Adult Human><Age><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Attenuated><BBB crossing><Bacteria><Behavioral><Binding><Blood Serum><Blood monocyte><Body Tissues><Brain><Brain Nervous System><Brain Trauma><Cellular Immune Function><Characteristics><Chronic><Circulation><Clinical><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Critical Illness><Critically Ill><Data><Diet><Dietary fiber fermentation><Disturbance in cognition><Encephalon><Energy Expenditure><Energy Metabolism><Enteral><Enteric><FFAR2><FFAR2 gene><Feces><Female><Fiber><Foundations><GI microbiome><GI microbiota><GPR43><Gastrointestinal microbiota><Gene Expression><Genes><Genetic><HPLC><Health><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Histology><Hortega cell><Human><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impaired cognition><Infiltration><Inflammatory><Injury><Intake><International><Intervention><Intestinal><Intestines><Ipsilateral><Lesion><Linear Models><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Macrophage><Magnetic Resonance Imaging><Marrow monocyte><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medicine><Memory><Mice><Mice Mammals><Microbiomics><Microglia><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular Interaction><Monitor><Morbidity><Murine><Mus><Mφ><NADPH Oxidase><NMR Imaging><NMR Tomography><Nerve Degeneration><Nervous System Injuries><Nervous System Trauma><Nervous System damage><Neurologic outcome><Neurological Damage><Neurological Injury><Neurological outcome><Neurological trauma><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Observational Study><Operative Procedures><Operative Surgical Procedures><Outcome Assessment><Patients><Performance><Peripheral><Phenotype><Population><Production><RNA Seq><RNA sequencing><RNAseq><Randomized><Reproducibility><Research><Research Resources><Resources><Resuscitation><Role><Serum><Severities><Short-Chain Fatty Acids><Sorting><Supplementation><Surgical><Surgical Interventions><Surgical Procedure><TAR DNA-binding protein 43><TBI recovery><TDP-43><TDP43><Technology><Testing><Therapeutic><Time><Tissues><Trauma><Traumatic Brain Injury><Traumatic Brain Injury recovery><Universities><Volatile Fatty Acids><Zeugmatography><active followup><adulthood><ages><attenuate><attenuates><blood-brain barrier crossing><bloodbrain barrier crossing><bowel><brain health><brain metabolism><brain tissue><cognitive dysfunction><cognitive loss><commensal bacteria><commensal bacterial species><community microbes><controlled cortical impact><dietary><dietary fiber digestion><diets><differential expression><differentially expressed><digestive tract microbiome><drinking water><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><fatty acid supplementation><field based data><field learning><field study><field test><follow up><follow-up><followed up><followup><free fatty acid receptor 2><functional outcomes><gastrointestinal microbial flora><gastrointestinal microbiome><gitter cell><glial activation><glial cell activation><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><immune function><improved><in vivo><injuries><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><male><mesoglia><metabolism measurement><metabolomics><metabonomics><metaproteomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiota><microbiota derived metabolites><microbiota metabolites><microflora><microglial cell><microgliocyte><microorganism community><microtubule bound tau><microtubule-bound tau><monocyte><morris water maze><morris watermaze><mouse model><multispecies consortia><murine model><nerve cell death><nerve cell loss><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neuroinflammation><neuroinflammatory><neurological degeneration><neurological recovery><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuronal survival><neuroprotection><neuroprotective><neurotoxic><neurotrauma><novel><observational research study><observational survey><perivascular glial cell><pharmacologic><polymicrobial community><premature><prematurity><prevent><preventing><prospective><protein TDP-43><protein TDP43><public health relevance><randomisation><randomization><randomly assigned><recovery after TBI><recovery after traumatic brain injury><restoration><secondary outcome><social role><stool><supplementation with fatty acids><surgery><tau><tau Proteins><tau factor><therapeutic target><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><translational study><traumatic brain damage><τ Proteins><♀><♂>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Michael Morowitz

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$586,588
FY 2026

Project Title

Impact of microbiota-derived metabolites on traumatic brain injury-related neurodegeneration

Grant Number:

5R01NS127372-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Traumatic brain injury (TBI)-related neurodegeneration (TReND) is increasingly recognized as a major health concern and cause of cognitive decline. Neuroinflammation, a proposed mechanism of TReND, may persist for years after the primary injury. We propose that chronic intestinal dysbiosis after TBI...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><21+ years old><Acceleration><Acetates><Acetylation><Active Follow-up><Address><Adult><Adult Human><Age><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Attenuated><BBB crossing><Bacteria><Behavioral><Binding><Blood Serum><Blood monocyte><Body Tissues><Brain><Brain Nervous System><Brain Trauma><Cellular Immune Function><Characteristics><Chronic><Circulation><Clinical><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Critical Illness><Critically Ill><Data><Diet><Dietary fiber fermentation><Disturbance in cognition><Encephalon><Energy Expenditure><Energy Metabolism><Enteral><Enteric><FFAR2><FFAR2 gene><Feces><Female><Fiber><Foundations><GI microbiome><GI microbiota><GPR43><Gastrointestinal microbiota><Gene Expression><Genes><Genetic><HPLC><Health><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Histology><Hortega cell><Human><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impaired cognition><Infiltration><Inflammatory><Injury><Intake><International><Intervention><Intestinal><Intestines><Ipsilateral><Lesion><Linear Models><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Macrophage><Magnetic Resonance Imaging><Marrow monocyte><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medicine><Memory><Mice><Mice Mammals><Microbiomics><Microglia><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular Interaction><Monitor><Morbidity><Murine><Mus><Mφ><NADPH Oxidase><NMR Imaging><NMR Tomography><Nerve Degeneration><Nervous System Injuries><Nervous System Trauma><Nervous System damage><Neurologic outcome><Neurological Damage><Neurological Injury><Neurological outcome><Neurological trauma><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Observational Study><Operative Procedures><Operative Surgical Procedures><Outcome Assessment><Patients><Performance><Peripheral><Phenotype><Population><Production><RNA Seq><RNA sequencing><RNAseq><Randomized><Reproducibility><Research><Research Resources><Resources><Resuscitation><Role><Serum><Severities><Short-Chain Fatty Acids><Sorting><Supplementation><Surgical><Surgical Interventions><Surgical Procedure><TAR DNA-binding protein 43><TBI recovery><TDP-43><TDP43><Technology><Testing><Therapeutic><Time><Tissues><Trauma><Traumatic Brain Injury><Traumatic Brain Injury recovery><Universities><Volatile Fatty Acids><Zeugmatography><active followup><adulthood><ages><attenuate><attenuates><blood-brain barrier crossing><bloodbrain barrier crossing><bowel><brain health><brain metabolism><brain tissue><cognitive dysfunction><cognitive loss><commensal bacteria><commensal bacterial species><community microbes><controlled cortical impact><dietary><dietary fiber digestion><diets><differential expression><differentially expressed><digestive tract microbiome><drinking water><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><fatty acid supplementation><field based data><field learning><field study><field test><follow up><follow-up><followed up><followup><free fatty acid receptor 2><functional outcomes><gastrointestinal microbial flora><gastrointestinal microbiome><gitter cell><glial activation><glial cell activation><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><immune function><improved><in vivo><injuries><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><male><mesoglia><metabolism measurement><metabolomics><metabonomics><metaproteomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiota><microbiota derived metabolites><microbiota metabolites><microflora><microglial cell><microgliocyte><microorganism community><microtubule bound tau><microtubule-bound tau><monocyte><morris water maze><morris watermaze><mouse model><multispecies consortia><murine model><nerve cell death><nerve cell loss><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neuroinflammation><neuroinflammatory><neurological degeneration><neurological recovery><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuronal survival><neuroprotection><neuroprotective><neurotoxic><neurotrauma><novel><observational research study><observational survey><perivascular glial cell><pharmacologic><polymicrobial community><premature><prematurity><prevent><preventing><prospective><protein TDP-43><protein TDP43><public health relevance><randomisation><randomization><randomly assigned><recovery after TBI><recovery after traumatic brain injury><restoration><secondary outcome><social role><stool><supplementation with fatty acids><surgery><tau><tau Proteins><tau factor><therapeutic target><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><translational study><traumatic brain damage><τ Proteins><♀><♂>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ava M. Puccio

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$586,588
FY 2026

Project Title

Impact of microbiota-derived metabolites on traumatic brain injury-related neurodegeneration

Grant Number:

5R01NS127372-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Traumatic brain injury (TBI)-related neurodegeneration (TReND) is increasingly recognized as a major health concern and cause of cognitive decline. Neuroinflammation, a proposed mechanism of TReND, may persist for years after the primary injury. We propose that chronic intestinal dysbiosis after TBI...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><21+ years old><Acceleration><Acetates><Acetylation><Active Follow-up><Address><Adult><Adult Human><Age><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Attenuated><BBB crossing><Bacteria><Behavioral><Binding><Blood Serum><Blood monocyte><Body Tissues><Brain><Brain Nervous System><Brain Trauma><Cellular Immune Function><Characteristics><Chronic><Circulation><Clinical><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Critical Illness><Critically Ill><Data><Diet><Dietary fiber fermentation><Disturbance in cognition><Encephalon><Energy Expenditure><Energy Metabolism><Enteral><Enteric><FFAR2><FFAR2 gene><Feces><Female><Fiber><Foundations><GI microbiome><GI microbiota><GPR43><Gastrointestinal microbiota><Gene Expression><Genes><Genetic><HPLC><Health><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Histology><Hortega cell><Human><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impaired cognition><Infiltration><Inflammatory><Injury><Intake><International><Intervention><Intestinal><Intestines><Ipsilateral><Lesion><Linear Models><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Macrophage><Magnetic Resonance Imaging><Marrow monocyte><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medicine><Memory><Mice><Mice Mammals><Microbiomics><Microglia><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular Interaction><Monitor><Morbidity><Murine><Mus><Mφ><NADPH Oxidase><NMR Imaging><NMR Tomography><Nerve Degeneration><Nervous System Injuries><Nervous System Trauma><Nervous System damage><Neurologic outcome><Neurological Damage><Neurological Injury><Neurological outcome><Neurological trauma><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Observational Study><Operative Procedures><Operative Surgical Procedures><Outcome Assessment><Patients><Performance><Peripheral><Phenotype><Population><Production><RNA Seq><RNA sequencing><RNAseq><Randomized><Reproducibility><Research><Research Resources><Resources><Resuscitation><Role><Serum><Severities><Short-Chain Fatty Acids><Sorting><Supplementation><Surgical><Surgical Interventions><Surgical Procedure><TAR DNA-binding protein 43><TBI recovery><TDP-43><TDP43><Technology><Testing><Therapeutic><Time><Tissues><Trauma><Traumatic Brain Injury><Traumatic Brain Injury recovery><Universities><Volatile Fatty Acids><Zeugmatography><active followup><adulthood><ages><attenuate><attenuates><blood-brain barrier crossing><bloodbrain barrier crossing><bowel><brain health><brain metabolism><brain tissue><cognitive dysfunction><cognitive loss><commensal bacteria><commensal bacterial species><community microbes><controlled cortical impact><dietary><dietary fiber digestion><diets><differential expression><differentially expressed><digestive tract microbiome><drinking water><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><fatty acid supplementation><field based data><field learning><field study><field test><follow up><follow-up><followed up><followup><free fatty acid receptor 2><functional outcomes><gastrointestinal microbial flora><gastrointestinal microbiome><gitter cell><glial activation><glial cell activation><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><immune function><improved><in vivo><injuries><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><male><mesoglia><metabolism measurement><metabolomics><metabonomics><metaproteomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiota><microbiota derived metabolites><microbiota metabolites><microflora><microglial cell><microgliocyte><microorganism community><microtubule bound tau><microtubule-bound tau><monocyte><morris water maze><morris watermaze><mouse model><multispecies consortia><murine model><nerve cell death><nerve cell loss><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neuroinflammation><neuroinflammatory><neurological degeneration><neurological recovery><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuronal survival><neuroprotection><neuroprotective><neurotoxic><neurotrauma><novel><observational research study><observational survey><perivascular glial cell><pharmacologic><polymicrobial community><premature><prematurity><prevent><preventing><prospective><protein TDP-43><protein TDP43><public health relevance><randomisation><randomization><randomly assigned><recovery after TBI><recovery after traumatic brain injury><restoration><secondary outcome><social role><stool><supplementation with fatty acids><surgery><tau><tau Proteins><tau factor><therapeutic target><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><translational study><traumatic brain damage><τ Proteins><♀><♂>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Dennis William Simon

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$586,588
FY 2026

Project Title

Impact of microbiota-derived metabolites on traumatic brain injury-related neurodegeneration

Grant Number:

5R01NS127372-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Traumatic brain injury (TBI)-related neurodegeneration (TReND) is increasingly recognized as a major health concern and cause of cognitive decline. Neuroinflammation, a proposed mechanism of TReND, may persist for years after the primary injury. We propose that chronic intestinal dysbiosis after TBI...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><21+ years old><Acceleration><Acetates><Acetylation><Active Follow-up><Address><Adult><Adult Human><Age><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Attenuated><BBB crossing><Bacteria><Behavioral><Binding><Blood Serum><Blood monocyte><Body Tissues><Brain><Brain Nervous System><Brain Trauma><Cellular Immune Function><Characteristics><Chronic><Circulation><Clinical><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Critical Illness><Critically Ill><Data><Diet><Dietary fiber fermentation><Disturbance in cognition><Encephalon><Energy Expenditure><Energy Metabolism><Enteral><Enteric><FFAR2><FFAR2 gene><Feces><Female><Fiber><Foundations><GI microbiome><GI microbiota><GPR43><Gastrointestinal microbiota><Gene Expression><Genes><Genetic><HPLC><Health><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Histology><Hortega cell><Human><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impaired cognition><Infiltration><Inflammatory><Injury><Intake><International><Intervention><Intestinal><Intestines><Ipsilateral><Lesion><Linear Models><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Macrophage><Magnetic Resonance Imaging><Marrow monocyte><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medicine><Memory><Mice><Mice Mammals><Microbiomics><Microglia><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular Interaction><Monitor><Morbidity><Murine><Mus><Mφ><NADPH Oxidase><NMR Imaging><NMR Tomography><Nerve Degeneration><Nervous System Injuries><Nervous System Trauma><Nervous System damage><Neurologic outcome><Neurological Damage><Neurological Injury><Neurological outcome><Neurological trauma><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Observational Study><Operative Procedures><Operative Surgical Procedures><Outcome Assessment><Patients><Performance><Peripheral><Phenotype><Population><Production><RNA Seq><RNA sequencing><RNAseq><Randomized><Reproducibility><Research><Research Resources><Resources><Resuscitation><Role><Serum><Severities><Short-Chain Fatty Acids><Sorting><Supplementation><Surgical><Surgical Interventions><Surgical Procedure><TAR DNA-binding protein 43><TBI recovery><TDP-43><TDP43><Technology><Testing><Therapeutic><Time><Tissues><Trauma><Traumatic Brain Injury><Traumatic Brain Injury recovery><Universities><Volatile Fatty Acids><Zeugmatography><active followup><adulthood><ages><attenuate><attenuates><blood-brain barrier crossing><bloodbrain barrier crossing><bowel><brain health><brain metabolism><brain tissue><cognitive dysfunction><cognitive loss><commensal bacteria><commensal bacterial species><community microbes><controlled cortical impact><dietary><dietary fiber digestion><diets><differential expression><differentially expressed><digestive tract microbiome><drinking water><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><fatty acid supplementation><field based data><field learning><field study><field test><follow up><follow-up><followed up><followup><free fatty acid receptor 2><functional outcomes><gastrointestinal microbial flora><gastrointestinal microbiome><gitter cell><glial activation><glial cell activation><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><immune function><improved><in vivo><injuries><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><male><mesoglia><metabolism measurement><metabolomics><metabonomics><metaproteomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiota><microbiota derived metabolites><microbiota metabolites><microflora><microglial cell><microgliocyte><microorganism community><microtubule bound tau><microtubule-bound tau><monocyte><morris water maze><morris watermaze><mouse model><multispecies consortia><murine model><nerve cell death><nerve cell loss><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neuroinflammation><neuroinflammatory><neurological degeneration><neurological recovery><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuronal survival><neuroprotection><neuroprotective><neurotoxic><neurotrauma><novel><observational research study><observational survey><perivascular glial cell><pharmacologic><polymicrobial community><premature><prematurity><prevent><preventing><prospective><protein TDP-43><protein TDP43><public health relevance><randomisation><randomization><randomly assigned><recovery after TBI><recovery after traumatic brain injury><restoration><secondary outcome><social role><stool><supplementation with fatty acids><surgery><tau><tau Proteins><tau factor><therapeutic target><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><translational study><traumatic brain damage><τ Proteins><♀><♂>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Amber Fyfe-Johnson

WASHINGTON STATE UNIVERSITY, PULLMAN, WA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$583,253
FY 2026

Project Title

Childhood Obesity: the role of the gut Microbiome, outdoor Time, and Stress(COMETS)

Grant Number:

5R01HL168373-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT One third of US children have overweight or obesity; children are developing obesity at higher rates than at any other time in human history. Social determinants of health (SDoH) are strong and especially intractable risk factors for childhood obesity, creating a structural ...

Research Terms

<0-11 years old><21+ years old><5 year old><5 years of age><Adult><Adult Human><Aeroseb-HC><Affect><Alimentary Canal><Application Context><Area><Assay><BMI><BMI percentile><BMI z-score><Behavior><Bioassay><Biological><Biological Assay><Biological Markers><Body mass index><Budgets><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cetacort><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Chronic stress><Communities><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Cost Effectiveness Analysis><Cost-Benefit Analysis><Country><Cross-Sectional Studies><Cross-Sectional Survey><Curriculum><Dermacort><Digestive Tract><Disease Frequency Surveys><Economic Income><Economical Income><Educational Curriculum><Effectiveness><Eldecort><Eligibility><Eligibility Determination><Enrollment><Environmental Factor><Environmental Risk Factor><Epidemiologic Research><Exhibits><Exposure to><Family><GI Tract><GI microbiome><Gastrointestinal Tract><Gastrointestinal tract structure><Green space><Health><Health Status Index><Health Status Indicators><Heart Vascular><History><Household><Human><Hydrocortisone><Hydrocortone><Hytone><Income><Individual><Individual Adjustment><Inequity><Influentials><Intervention><Investments><Learning><Life><Link><Location><Mediation><Mediator><Microbe><Modeling><Modern Man><NHLBI><National Heart, Lung, and Blood Institute><Natural experiment><Nature><Negotiating><Negotiation><Neighborhoods><Nursery Schools><Nutracort><Obesity><Obesity Epidemic><Outcome><Outcome Measure><Overweight><Performance><Persons><PhenX Toolkit><Phenotypes and eXposures Toolkit><Phenx><Physical activity><Physiologic><Physiological><Play><Policies><Population><Prevention><Proctocort><Protocol><Protocol Screening><Protocols documentation><Public Health><Quetelet index><Recording of previous events><Research><Risk Factors><Role><Sample Size><Sampling><Socio-economic status><Socioeconomic Status><Socioeconomically disadvantaged><Soil><Spottings><Stress><Students><Testing><Time><Trees><Visit><Waiting Lists><adiposity><adulthood><age 5><age 5 years><alimentary tract><bio-markers><biologic><biologic marker><biomarker><build resilience><build resiliency><built environment><child adiposity><child obesity><childhood adiposity><childhood obesity><circulatory system><contextual factors><corpulence><cost benefit economics><cost benefit effectiveness><cost efficient analysis><cost-effective analysis><critical period><cross-sectional research study><develop resilience><develop resiliency><digestive canal><digestive tract microbiome><early childhood><economic security><economic self-sufficiency><economic stability><economic well-being><education access><enhance resilience><enhance resiliency><enroll><enteric microbiome><environmental risk><epidemiologic investigation><experiment><experimental research><experimental study><experiments><facilitate resilience><fecal sample><financial security><financial stability><financial well-being><five year old><five years of age><gastrointestinal microbiome><greenspace><gut microbiome><gut-associated microbiome><histories><improve resilience><improve resiliency><improved><incomes><increase resilience><increase resiliency><indexing><innovate><innovation><innovative><intestinal biome><intestinal microbiome><investigate epidemiology><kids><lesson plans><life span><lifespan><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><measurable outcome><metropolitan><microbial><microorganism><mortality><novel><obese children><obesigenic><obesity during childhood><obesity in children><obesity management><obesity prevention><obesogenic><outcome measurement><pediatric><pediatric obesity><pre-k><pre-kindergarten><preschool><prevent><prevent obesity><preventing><primary outcome><programs><promote resilience><promote resiliency><prospective><psychologic><psychological><recruit><resilience><resilience development><resilient><secondary outcome><social><social health determinants><social role><social structural><social structure><socio-economic disadvantage><socio-economic position><socio-economically disadvantaged><socio-economically underprivileged><socio-structural><socioeconomic disadvantage><socioeconomic position><socioeconomically underprivileged><sociostructural><stool sample><stool specimen><stress reduction><study epidemiology><survey epidemiology><urban environment><urban setting><waitlist><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

John Nicholas Betley

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$541,468
FY 2026

Project Title

Intestinal regulation of exercise performance

Grant Number:

5R01NS134976-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/16/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Exercise is an extremely effective lifestyle intervention that dramatically lowers the risk for cardiovascular, metabolic, neoplastic, chronic inflammatory, and neurodegenerative diseases. Despite these beneficial effects, the modern human lifestyle is highly sedentary and new approaches to ...

Research Terms

<Address><Afferent Neurons><Alimentary Canal><Amides><Animals><Automobile Driving><Behavior><Behavioral><Brain><Brain Nervous System><CB1><CB1 Receptor><CB1R><CNR1 gene><Cancers><Cannabinoid Receptor CB1><Cardiovascular Diseases><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chronic Disease><Chronic Illness><Communication><Corpus Striatum><Corpus striatum structure><D1 receptor><Data><Degenerative Neurologic Disorders><Development><Diabetes Mellitus><Diet><Dietary Intervention><Digestive Tract><Disease><Disorder><Dopamine><Dopamine D1 Receptor><Elements><Encephalon><Endocannabinoids><Endogenous Cannabinoids><Exercise><Exercise Physiology><Fatty Acids><Future><GI Tract><GI microbiome><GI microbiota><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Gene Cluster><Gene Expression><General Population><General Public><General Taxonomy><Genes><Genetic><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><Habits><Health Benefit><Human><Hydroxytyramine><Immediate-Early Genes><Individual><Inflammatory><Intervention><Intestinal><Intestines><Intracellular Communication and Signaling><Investigation><Life Style><Lifestyle><Link><Literature><Malignant Neoplasms><Malignant Tumor><Measurement><Measures><Mediating><Metabolic><Mice><Mice Mammals><Microbiomics><Modern Man><Modernization><Molecular><Monitor><Motivation><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neuronal Transmission><Neurons><Neurosciences><Nutrition Interventions><Nutritional Interventions><Operative Procedures><Operative Surgical Procedures><Output><Performance><Peripheral><Physical activity><Population><Psychological reinforcement><Publishing><Regulation><Reinforcement><Research><Rewards><Role><Sensory><Sensory Neurons><Signal Transduction><Signal Transduction Systems><Signaling><Striate Body><Striatum><Surgical><Surgical Interventions><Surgical Procedure><TRPV1><TRPV1 gene><Taxonomy><Testing><Therapeutic><Work><alimentary tract><axon signaling><axon-glial signaling><axonal signaling><biological signal transduction><bowel><brain control><brain pathway><cannabinoid receptor 1><cannabinoid receptor type 1><cannabinoid type 1><cardiovascular disorder><cardiovascular risk><cardiovascular risk factor><chronic disorder><collaborative approach><commensal flora><commensal microbes><commensal microbiota><commensal microflora><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diabetes><diet intervention><dietary><diets><digestive canal><digestive tract microbiome><driving><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><gastrointestinal><gastrointestinal microbial flora><gastrointestinal microbiome><glia signaling><glial signaling><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><host microbiome><improved><innovate><innovation><innovative><insight><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><lens><lenses><life style intervention><life-style factor><lifestyle factors><lifestyle intervention><malignancy><member><microbial><microbial colonization><microbial consortia><microbial flora><microbiome><microbiome research><microbiome science><microbiome studies><microbiota><microflora><multispecies consortia><neoplasm/cancer><neoplastic><nerve signaling><neural><neural degeneration><neural signaling><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><neuronal signaling><neurophysiological><neurophysiology><neurotransmission><new approaches><novel approaches><novel strategies><novel strategy><pharmacologic><pre-clinical><preclinical><prevent><preventing><rational design><response><sedentary><social role><striatal><surgery><tool><transient receptor potential cation channel V1><willingness>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Christoph Alexander Thaiss

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$541,468
FY 2026

Project Title

Intestinal regulation of exercise performance

Grant Number:

5R01NS134976-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/16/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Exercise is an extremely effective lifestyle intervention that dramatically lowers the risk for cardiovascular, metabolic, neoplastic, chronic inflammatory, and neurodegenerative diseases. Despite these beneficial effects, the modern human lifestyle is highly sedentary and new approaches to ...

Research Terms

<Address><Afferent Neurons><Alimentary Canal><Amides><Animals><Automobile Driving><Behavior><Behavioral><Brain><Brain Nervous System><CB1><CB1 Receptor><CB1R><CNR1 gene><Cancers><Cannabinoid Receptor CB1><Cardiovascular Diseases><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chronic Disease><Chronic Illness><Communication><Corpus Striatum><Corpus striatum structure><D1 receptor><Data><Degenerative Neurologic Disorders><Development><Diabetes Mellitus><Diet><Dietary Intervention><Digestive Tract><Disease><Disorder><Dopamine><Dopamine D1 Receptor><Elements><Encephalon><Endocannabinoids><Endogenous Cannabinoids><Exercise><Exercise Physiology><Fatty Acids><Future><GI Tract><GI microbiome><GI microbiota><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Gene Cluster><Gene Expression><General Population><General Public><General Taxonomy><Genes><Genetic><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><Habits><Health Benefit><Human><Hydroxytyramine><Immediate-Early Genes><Individual><Inflammatory><Intervention><Intestinal><Intestines><Intracellular Communication and Signaling><Investigation><Life Style><Lifestyle><Link><Literature><Malignant Neoplasms><Malignant Tumor><Measurement><Measures><Mediating><Metabolic><Mice><Mice Mammals><Microbiomics><Modern Man><Modernization><Molecular><Monitor><Motivation><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neuronal Transmission><Neurons><Neurosciences><Nutrition Interventions><Nutritional Interventions><Operative Procedures><Operative Surgical Procedures><Output><Performance><Peripheral><Physical activity><Population><Psychological reinforcement><Publishing><Regulation><Reinforcement><Research><Rewards><Role><Sensory><Sensory Neurons><Signal Transduction><Signal Transduction Systems><Signaling><Striate Body><Striatum><Surgical><Surgical Interventions><Surgical Procedure><TRPV1><TRPV1 gene><Taxonomy><Testing><Therapeutic><Work><alimentary tract><axon signaling><axon-glial signaling><axonal signaling><biological signal transduction><bowel><brain control><brain pathway><cannabinoid receptor 1><cannabinoid receptor type 1><cannabinoid type 1><cardiovascular disorder><cardiovascular risk><cardiovascular risk factor><chronic disorder><collaborative approach><commensal flora><commensal microbes><commensal microbiota><commensal microflora><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diabetes><diet intervention><dietary><diets><digestive canal><digestive tract microbiome><driving><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><gastrointestinal><gastrointestinal microbial flora><gastrointestinal microbiome><glia signaling><glial signaling><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><host microbiome><improved><innovate><innovation><innovative><insight><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><lens><lenses><life style intervention><life-style factor><lifestyle factors><lifestyle intervention><malignancy><member><microbial><microbial colonization><microbial consortia><microbial flora><microbiome><microbiome research><microbiome science><microbiome studies><microbiota><microflora><multispecies consortia><neoplasm/cancer><neoplastic><nerve signaling><neural><neural degeneration><neural signaling><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><neuronal signaling><neurophysiological><neurophysiology><neurotransmission><new approaches><novel approaches><novel strategies><novel strategy><pharmacologic><pre-clinical><preclinical><prevent><preventing><rational design><response><sedentary><social role><striatal><surgery><tool><transient receptor potential cation channel V1><willingness>
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Scott Edward Kanoski

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$537,628
FY 2026

Project Title

Interactions between diet and cognition

Grant Number:

5R01DK123423-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2019

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Consumption of an obesity-promoting “Western diet” (WD) is strongly associated with cognitive impairment and dementia risk, even independent of obesity 1-5. The hippocampus (HPC), a brain region classically associated with memory function and more recently with energy balance, is pa...

Research Terms

<0-11 years old><21+ years old><ACh Receptors><AD and related dementia><AD related dementia><ADRD><Acetylcholine><Acetylcholine Receptors><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Amentia><Ammon Horn><Autoregulation><Behavioral Mechanisms><Bifidobacterium><Binding><Biological><Brain><Brain Nervous System><Brain region><Caloric Intake><Calories><Cell Communication and Signaling><Cell Signaling><Child><Child Youth><Children (0-21)><Cholinergic Receptors><Cholinoceptive Sites><Cholinoceptors><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive Retention Disorders><Cognitive decline><Cognitive function abnormal><Common Rat Strains><Consumption><Cornu Ammonis><Data><Dementia><Development><Diet><Dietary Factors><Dietary Intervention><Disease><Disorder><Disturbance in cognition><Dysfunction><Eating><Eating Behavior><Encephalon><Energy Expenditure><Energy Intake><Energy Metabolism><Environment><Feeding behaviors><Food><Food Intake><Functional disorder><Funding><GI microbiome><GLP-1><Gastrointestinal Process><Glp-1><Healthy diet><Hippocampus><Homeostasis><Hyperphagia><Impaired cognition><Ingestive Behavior><Insulinoma amyloid peptide><Intermediary Metabolism><Intestinal><Intestines><Intracellular Communication and Signaling><Lactococcus><Life><Link><Locomotor Activity><Mechanisms of Behavior and Behavior Change><Mediating><Memory><Memory Deficit><Memory Disorders><Memory impairment><Metabolic><Metabolic Processes><Metabolism><Modeling><Molecular Interaction><Motor Activity><Network Analysis><Neurocognition><Neurocognitive><Nutrition Interventions><Nutritional Interventions><Obesity><Outcome><Overeating><Pancreas><Pancreatic><Pathway Analysis><Performance><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Population><Probiotics><Process><Publications><Rat><Rats Mammals><Rattus><Risk><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><Satiation><Scientific Publication><Signal Transduction><Signal Transduction Systems><Signaling><Stomach><Testing><Unhealthy Diet><Visuospatial><Weight Gain><Weight Increase><Work><adiposity><adulthood><amlintide><amylin><bacterial genome sequencing><bacterial whole genome sequencing><balanced diet><behavior mechanism><biologic><biological signal transduction><body weight gain><body weight increase><bowel><caloric dietary content><calorie><cholinergic><cognitive dysfunction><cognitive loss><corpulence><dementia risk><developmental><diabetes associated peptide><diet intervention><dietary><diets><digestive tract microbiome><energy balance><enteric microbiome><experiment><experimental research><experimental study><experiments><feeding-related behaviors><gastric><gastrointestinal microbiome><glucagon-like peptide 1><good diet><gut microbiome><gut-associated microbiome><hippocampal><human model><imaging in vivo><in vivo><in vivo imaging><insulinoma amyloid polypeptide><intestinal biome><intestinal microbiome><islet amyloid polypeptide><juvenile><juvenile human><kids><later in life><later life><life span><lifespan><memory dysfunction><microbial><microbiome><mid life><mid-life><middle age><middle aged><midlife><model of human><neural><neural mechanism><neurobiological mechanism><neuromechanism><novel><nutrient intake activity><pancreatic amylin><pathophysiology><pharmacologic><polyphagia><poor diet><programs><respiratory><response><risk factor for dementia><risk for dementia><satiety><saturated dietary fat><saturated dietary lipid><saturated fat><saturated lipid><social role><sugar><visual spatial><western diet><western-style diet><western-type diet><wt gain><youngster>
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Matthew R Redinbo

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$536,223
FY 2026

Project Title

Gut Microbial Enzymes and Human Disease

Grant Number:

5R35GM152079-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Although it has been established that the gut microbiota influence normal physiology and transitions to disease, the roles played by microbial proteins in these complex molecular processes are still poorly understood. Through this project, we will examine the structures and functions...

Research Terms

<5-HT><5-Hydroxytryptamine><5HT><Amino Acids><Animal Model><Animal Models and Related Studies><Beta-glucuronidase><Bile Acids><Biochemistry><Biological Chemistry><Biology><C diff><C difficile><C. diff><C. difficile><Cardiac Diseases><Cardiac Disorders><Chemicals><Clinical><Clostridioides difficile><Clostridium difficile><Complex><Development><Disease><Disorder><Dopamine><Enteramine><Enzyme Antagonist><Enzyme Gene><Enzyme Inhibitor><Enzyme Inhibitor Agent><Enzyme Inhibitor Drugs><Enzymes><Estrogens><GI microbiome><GI microbiota><Gastrointestinal microbiota><Glucuronidase><Heart Diseases><Hippophaine><Human><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><Hydroxytyramine><Indican><Indoles><Indoxyl Sulfate><Infection><Kidney Diseases><L-tryptophanase><Modern Man><Molecular><Nephropathy><Nerve Transmitter Substances><Neurotransmitters><Pathway interactions><Physiology><Play><Pregnant Women><Process><Protein Family><Proteins><Recurrence><Recurrent><Renal Disease><Research><Role><Sampling><Serotonin><Source><Structure><TDO2><TRPO><Therapeutic Estrogen><Therapeutic Steroid Hormone><Toxin><Tryptamin 2,3-Dioxygenase><Tryptophan 2,3-Dioxygenase><Tryptophan Indole-Lyase><Tryptophanase><Uremia><aminoacid><antenatal depression><antepartum depression><beta-D-Glucuronoside glucuronosohydrolase><bile salts><depression during pregnancy><depression in pregnancy><developmental><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><expectant mother><expectant women><expecting mother><expecting women><experience><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heart disorder><human disease><individuals who are pregnant><inhibitor><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kidney disorder><microbial><microbial consortia><microbial flora><microbiota><microflora><model of animal><mouse model><multiomics><multiple omics><multispecies consortia><murine model><new diagnostics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation diagnostics><next generation therapeutics><novel><novel diagnostics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><panomics><pathway><people who are pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal depression><prenatal depressive symptoms><programs><renal disorder><small molecule><social role><steroid hormone><those who are pregnant><tool><uremia of renal origin><women who are pregnant><β-D-Glucuronoside glucuronosohydrolase><β-glucuronidase>
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Lisa M Bebell

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$533,813
FY 2026

Project Title

Microbiome-driven immune changes and growth stunting in HIV-exposed uninfected children

Grant Number:

5R01HD112302-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/11/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Despite increasing access to antiretroviral therapy (ART) in pregnancy, the >1 million children born annually to pregnant women with HIV (PHIV) who are HIV-exposed but uninfected (HEU) remain at >2-fold higher risk of growth stunting and infectious morbidity than HIV-unexposed children. Though the o...

Research Terms

<0-11 years old><0-4 weeks old><5 year old><5 years of age><7S Gamma Globulin><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Follow-up><Address><Antibodies><Antibody Response><Autoregulation><B blood cells><B cell><B cells><B-Cell Subsets><B-Cells><B-Lymphocyte Subsets><B-Lymphocytes><B-cell><Biological><Birth><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Serum><Blood monocyte><Breast Feeding><Breast Milk><Breastmilk><Caring><Cells Placenta-Tissue><Characteristics><Child><Child Health><Child Youth><Childhood><Children (0-21)><Clinical><Communicable Diseases><Communication><Data><Defect><Development><Diarrhea><Diet><Early Intervention><Early identification><Enrollment><Enteral><Enteric><Environmental Exposure><Epidemiology><Fc Receptor><Feces><Food><Functional Metagenomics><GI microbiome><Generalized Growth><Gestation><Goals><Growth><HIV><HIV disease status><HIV infection status><HIV serostatus><HIV status><HIV1 infection status><HIV1 status><Health><Homeostasis><Human Immunodeficiency Viruses><Human Milk><Human Mother's Milk><IgA><IgG><Immune><Immune response><Immune system><Immunes><Immunity><Immunoglobulin A><Immunoglobulin G><Immunology><Infection><Infectious Diseases><Infectious Disorder><Inflammatory><Infrastructure><Innate Immune Response><Investigators><LAV-HTLV-III><Laboratories><Link><Long-term cohort><Longitudinal cohort><Lymphadenopathy-Associated Virus><Mammary Gland Milk><Marrow monocyte><Maternal Immunity><Maternally-Acquired Immunity><Measures><Metadata><Metagenomics><Microbe><Morbidity><Mother's Milk><Mothers><NIH><National Institutes of Health><Neonatal><Newborn Infant><Newborns><Normal Placentoma><Nutrition><Nutritional status><Organism><Outcome><Parturition><Pathogenicity><Pathway interactions><Physiological Homeostasis><Placenta><Placenta Embryonic Tissue><Placentome><Plasma><Plasma Serum><Play><Pneumonia><Predisposition><Pregnancy><Pregnant Women><Proteobacteria><Public Health><Purple Bacteria><Receptor Protein><Recurrence><Recurrent><Reporting><Research><Research Personnel><Researchers><Resolution><Reticuloendothelial System, Serum, Plasma><Risk><Sampling><Serology><Serum><Shapes><Short-Chain Fatty Acids><Source><Susceptibility><System><T-Cells><T-Lymphocyte><Time><Tissue Growth><Uganda><Umbilical Cord><Umbilical cord structure><United States National Institutes of Health><Vaccination><Viral><Virulence><Virus-HIV><Volatile Fatty Acids><Work><active followup><age 5><age 5 years><anti-microbial><antibody receptor><antibody transfer><antimicrobial><antiretroviral therapy><antiretroviral treatment><biobank><biologic><biorepository><burden of disease><burden of illness><co-morbid><co-morbidity><cohort><comorbidity><data pipeline><developmental><diarrheal disease><diarrheal illness><diets><digestive tract microbiome><disease burden><disease model><disorder model><enroll><enteric microbiome><epidemiologic><epidemiological><expectant mother><expectant women><expecting mother><expecting women><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><five year old><five years of age><follow up><follow-up><followed up><followup><gastrointestinal microbiome><gut microbiome><gut microbiome of infant><gut-associated microbiome><high risk><host response><immune system response><immunization strategy><immunoresponse><improved><improved outcome><individuals who are pregnant><infant gut microbiome><infection recurrence><innovate><innovation><innovative><intestinal biome><intestinal microbiome><kids><living system><maternal milk><meta data><metabolism measurement><metabolomics><metabonomics><microbial><microbiome><microbiome community composition><microbiome composition><microbiome intervention><microbiome species composition><microbiome structure><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><monocyte><mortality><neonate gut microbiome><newborn child><newborn children><newborn gut microbiome><novel><ontogeny><pathobiont><pathogen><pathway><pediatric><peer><people who are pregnant><poor health outcome><pregnant females><pregnant mothers><pregnant people><pregnant populations><prospective><receptor><receptor binding><receptor bound><recurrent infection><recurring infection><reduced health outcome><resolutions><species difference><stool><stool sample><stool specimen><those who are pregnant><thymus derived lymphocyte><vaccination strategy><vaccine response><vaccine responsiveness><vaccine strategy><vaccine-induced response><women who are pregnant><worse health outcome><youngster>
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Chun-Jun Guo

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$491,469
FY 2026

Project Title

Molecular mechanisms behind microbiota regulation of host amino acid and glucose homeostasis

Grant Number:

5R01DK135816-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Type 2 Diabetes (T2D) prevalence increases with age and affects over 13.2% of the US population by 2020. Studies show that microbiota composition and their metabolic genes are different between healthy and T2D patients. However, it is challenging to unravel their causal effects on host glucose homeo...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><5-HT><5-Hydroxytryptamine><5HT><AH Receptors><Adult-Onset Diabetes Mellitus><Affect><Age><Amino Acid Metabolism - Reference Pathway><Amino Acid Metabolism Pathway><Amino Acids><Aryl Hydrocarbon Receptor><Assay><Autoregulation><Bioassay><Bioavailability><Bioinformatics><Biological><Biological Assay><Biological Availability><Biology><Body Tissues><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clinical><Code><Coding System><Collection><Communities><Complex><Consumption><D-Glucose><Data><Dextrose><Diabetic mouse><Diet><Dioxin Receptors><Disease><Disorder><Dysfunction><EC Cell><Economic Burden><Engineering><Enteramine><Enterochromaffin><Enterochromaffin Cells><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Fermentation><Functional disorder><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Modified><Genes><Genetic><Genomics><Germ-Free><Glucose><Gnotobiotic><Gnotobiotics><Health><Hippophaine><Homeostasis><Human><Human Figure><Human body><In Vitro><Intermediary Metabolism><Intestinal><Intestines><Intracellular Communication and Signaling><Investigation><KO mice><Ketosis-Resistant Diabetes Mellitus><Knock-out Mice><Knockout Mice><Kynurenine><L-Tryptophan><Learning><Levotryptophan><Maturity-Onset Diabetes Mellitus><Mediating><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Pathway><Metabolic Processes><Metabolism><Mice><Mice Mammals><Microbe><Microbial Genetics><Modern Man><Molecular><Motivation><Murine><Mus><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nuclear Translocator><Null Mouse><Nutrient><Pathway interactions><Patients><Peripheral><Phylogenetic Analysis><Phylogenetics><Physiologic Availability><Physiological Homeostasis><Physiopathology><Play><Polyaromatic Hydrocarbon Receptors><Population><Prevalence><Public Health><Publishing><Receptor Signaling><Regulation><Role><Sampling><Science of Microbial Genetics><Serotonin><Severity of illness><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Site><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><System><T2 DM><T2D><T2DM><TCDD Receptors><Testing><Therapeutic><Thesaurismosis><Tissues><Tryptophan><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Work><adult onset diabetes><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><ages><ahr ligand><amino acid metabolism><aminoacid><aryl hydrocarbon receptor ligand><bacteria in the gut><bacterial genetics><biologic><biological signal transduction><blood glucose regulation><bowel><causation><community microbes><diabetes mouse model><dietary><diets><digestive tract microbiome><disease causation><disease severity><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><epigenetically><gastrointestinal microbial flora><gastrointestinal microbiome><gene manipulation><gene modification><gene synthesis><genetic manipulation><genetically manipulate><genetically modified><genetically perturb><glucose control><glucose homeostasis><glucose metabolism><glucose regulation><glucose tolerance><gut bacteria><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiota><in vivo><inhibitor><insight><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><ketosis resistant diabetes><longitudinal data set><longitudinal dataset><maturity onset diabetes><member><metabolic phenotype><metabolism disorder><metabolism measurement><metabolomics><metabonomics><metabotype><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbiome><microbiota><microbiota composition><microflora><microorganism community><microorganism genetics><mouse model><multiomics><multiple omics><multispecies consortia><murine model><mutant><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pan-genome><pangenome><panomics><pathophysiology><pathway><polymicrobial community><prevent><preventing><public health relevance><social role><synthetic biology><type 2 DM><type II DM><type two diabetes>
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Everett P Greenberg

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$427,625
FY 2026

Project Title

Bacterial quorum sensing

Grant Number:

5R35GM136218-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2020

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Quorum sensing (QS) is a form of cell-cell communication that allows members of a population to coordinate cooperative activities in a cell density-dependent fashion. I am interested in bacterial QS control of cooperative activities at a chemical, cellular and molecular level for thr...

Research Terms

<Address><Anti-Bacterial Agents><Area><Bacteria><Basal Transcription Factor><Basal transcription factor genes><Biologic Phenomena><Biological><Biological Phenomena><Biotech><Biotechnology><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Density><Cell Interaction><Cell Signaling><Cell-to-Cell Interaction><Cells><Chemicals><Communication><Complex><Costs and Benefits><Development><Disease><Disorder><Evolution><GI microbiome><Gene Expression><General Transcription Factor Gene><General Transcription Factors><Health><Human><Infection><Intestinal><Intestines><Intracellular Communication and Signaling><Knowledge><Modeling><Modern Man><Molecular><Molecular Genetics><P aeruginosa><P. aeruginosa><Play><Population><Population Biology><Position><Positioning Attribute><Pseudomonas aeruginosa><Pseudomonas pyocyanea><Research><Role><Signal Transduction><Signal Transduction Systems><Signaling><Social Controls><Social Interaction><System><Techniques><Therapeutic><Transcription Factor Proto-Oncogene><Transcription factor genes><Virulence><anti-bacterial><bacterial community><biologic><biological research><biological signal transduction><bowel><community microbes><developmental><digestive tract microbiome><enteric microbiome><gastrointestinal microbiome><genetic approach><genetic strategy><gut microbiome><gut-associated microbiome><homoserine lactone><human flora><human microbial communities><human microbiota><human microflora><human pathogen><human-associated microbial communities><human-associated microbiota><insight><interest><intestinal biome><intestinal microbiome><member><microbe community><microbial community><microbiome><microorganism community><novel><polymicrobial community><pressure><quorum sensing><social><social role><therapeutic agent development><therapeutic development><therapeutic target><transcription factor>
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Angela M Oliverio

SYRACUSE UNIVERSITY, SYRACUSE, NY

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$411,125
FY 2026

Project Title

Identifying fundamental principles of evolutionary dynamics in multispecies microbiomes

Grant Number:

1R35GM162848-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This research program will elucidate the causes and consequences of evolution in multispecies microbiomes, leveraging experimental evolution in synthetic systems. The human microbiome modulates key components of health and its disruption and has been linked to diseases including infl...

Research Terms

<Allergy><Biologic Models><Biological Models><Collection><Communities><Complex><Disease><Disorder><Evolution><Exhibits><Fermentation><Food><Foundations><GI microbiome><Genes><Genetic Diversity><Genetic Screening><Genetic Variation><Genomics><Goals><Health><Horizontal Gene Transfer><Human><Human Microbiome><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Lateral Gene Transfer><Link><Maintenance><Model System><Modeling><Modern Man><Mouth microbiome><Probiotics><Process><Research><Research Project Summaries><Shapes><Skin><System><Testing><Work><comparative genomics><cutaneous microbiome><dermal microbiome><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbiome><epidermal microbiome><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><human-associated microbiome><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><intestinal autoinflammation><intestinal biome><intestinal microbiome><long read seq><long-read sequencing><long-read transcript sequencing><member><microbial><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiota><microflora><multispecies consortia><oral microbiome><programs><skin biome><skin microbiome><success><tool><transcriptomics>
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Thomas E. Sharp

UNIVERSITY OF SOUTH FLORIDA, TAMPA, FL

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$400,850
FY 2026

Project Title

Alcohol-induced Gut Dysbiosis and Cardiovascular Disease

Grant Number:

5R01AA029984-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/8/2023

End Date:

2/28/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Hazardous alcohol use (HAU) leads to tremendous morbidity and mortality in millions of individuals in the United States and worldwide annually. The cognitive, neuronal, and psycho-social aspects of alcohol use have been well established. More recently, clinical, and basic research ha...

Research Terms

<ASCVD><Adoptive Transfer><Alcohol Chemical Class><Alcohol Drinking><Alcohol abuse><Alcohol consumption><Alcohols><American><Amines><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Attenuated><Autoregulation><Basic Research><Basic Science><Bioavailability><Biochemical><Biological Availability><Blood Vessels><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Carnitine><Cessation of life><Choline><Chronic><Clinical Research><Clinical Study><Cognitive><Death><Development><Diabetes Mellitus><Diagnosis><Diagnostic><Digestive Diseases><Digestive System Diseases><Digestive System Disorders><Disease><Disease Progression><Disorder><Dysfunction><Endogenous Nitrate Vasodilator><Endothelium-Derived Nitric Oxide><EtOH abuse><EtOH drinking><EtOH use><FMO3><Fishes><Flavins><Functional Metagenomics><Functional disorder><GI microbiome><GI microbiota><GI tract disorder><Gastrointestinal microbiota><Goals><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><Health><Health Care Costs><Health Costs><Health Status><Heart><Heart Vascular><Heart failure><Hepatic><Homeostasis><Hour><Hydroxylases><Hypertension><Individual><Inflammation><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Ischemic Heart><Ischemic Heart Disease><Ischemic myocardium><Level of Health><Link><Liver><Measurement><Meat><Mediating><Metabolic syndrome><Metagenomics><Mice><Mice Mammals><Mixed Function Oxidases><Mixed Function Oxygenases><Modeling><Mononitrogen Monoxide><Monooxygenases><Morbidity><Murine><Mus><Myocardial Ischemia><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nitric Oxide><Nitrogen Monoxide><Nitrogen Protoxide><Outcome><Oxides><Pathology><Patients><Physiologic><Physiologic Availability><Physiological><Physiological Homeostasis><Physiopathology><Play><Predisposition><Production><Prognosis><Prognostic Marker><Reperfusion Therapy><Research><Risk><Role><Series><Severities><Severity of illness><Susceptibility><Techniques><Therapeutic><Thrombus><Treatment Efficacy><United States><Vascular Diseases><Vascular Disorder><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><alcohol co-abuse><alcohol effect><alcohol ingestion><alcohol intake><alcohol problem><alcohol product use><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><amine><atheromatosis><atherosclerotic disease><atherosclerotic heart disease><atherosclerotic vascular disease><attenuate><attenuates><blood vessel disorder><cardiac failure><cardiac function><cardiac ischemia><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cardiovascular function><cardiovascular health><chronic EtOH drinking><chronic alcohol consumption><chronic alcohol drinking><chronic alcohol ingestion><chronic alcohol use><chronic ethanol consumption><chronic ethanol drinking><chronic ethanol ingestion><circulatory system><co-morbid><co-morbidity><comorbidity><coronary ischemia><cost><developmental><diabetes><dietary><digestive disorder><digestive tract disease><digestive tract microbiome><disease severity><dysbacteriosis><dysbiosis><dysbiotic><egg><endothelial cell derived relaxing factor><endothelial dysfunction><enteric microbial community><enteric microbiome><enteric microbiota><ethanol abuse><ethanol consumption><ethanol drinking><ethanol effect><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><ethanol use disorder><flavin-containing monooxygenase 3><function of the heart><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract disease><gastrointestinal tract disorder><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hazardous alcohol use><health level><heart function><heart infarct sizing><heart infarction sizing><heart ischemia><hepatic body system><hepatic organ system><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><inflammatory environment><inflammatory milieu><inhibitor><insight><intervention efficacy><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiota><microflora><mortality><mouse model><multispecies consortia><murine model><myocardial infarct sizing><myocardial infarction sizing><myocardial ischemia/hypoxia><myocardium ischemia><neuronal><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><oxidation><pathophysiology><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><prognostic biomarker><prognostic indicator><psychosocial><reperfusion><sex><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy><vascular><vascular dysfunction><vasculopathy>
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Alexandre W Bisson Filho

TRUSTEES OF INDIANA UNIVERSITY, BLOOMINGTON, IN

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$396,250
FY 2026

Project Title

Archaea as a microbial model for developmental mechanoplasticity

Grant Number:

7R35GM156992-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Cells with identical genomes can follow different developmental paths depending on their mechanical interactions with the environment. Archaea impact human health by playing critical roles in environmental cycles and animal microbiomes. Yet little is known about their cell biology. I...

Research Terms

<Address><Animals><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Behavior><Biochemical><Biologic Models><Biological><Biological Models><Biomechanics><Biophysical Process><Biophysics><Body Fluids><CRISPR interference><CRISPR-dCas9-mediated repression><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell Wall><Cells><Cellular Function><Cellular Matrix><Cellular Physiology><Cellular Process><Cellular biology><Clustered Regularly Interspaced Short Palindromic Repeats interference><Crowding><Cytoskeletal System><Cytoskeleton><Data><Development><Disease><Disorder><Environment><Expression Signature><Future><Gene Expression Profile><Genome><Glycoproteins><Haloferax volcanii><Health><Human><Human Microbiome><Image><Immune Globulins><Immunoglobulins><In Vitro><Laboratories><Libraries><Light><Mammalian Cell><Mechanical Stress><Mechanics><Microbe><Microbiomics><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Microfluidics><Model System><Modeling><Modern Man><Molecular><Molecular Probes><Outcome><Pathway interactions><Photoradiation><Physiologic><Physiological><Physiology><Play><Polymers><Population><Proteins><Research><Role><Sight><Subcellular Process><Technical Expertise><Translating><Vision><animal tissue><biologic><biomechanical><biophysical foundation><biophysical mechanism><biophysical principles><biophysical sciences><candidate identification><cell biology><developmental><entire genome><full genome><gene expression pattern><gene expression signature><gut health><human-associated microbiome><imaging><in vivo><insight><intracellular skeleton><live cell image><live cell imaging><live cellular image><live cellular imaging><mechanic><mechanical><mechanical cue><mechanical force><mechanical signal><microbial><microbiome><microbiome research><microbiome science><microbiome studies><microfluidic chip><pathway><polymer><polymeric><pressure><programs><reconstitute><reconstitution><repressing CRISPR-dCas9 system><response><reverse genetics><social role><spatial and temporal><spatial temporal><spatiotemporal><technical skills><transcriptional profile><transcriptional signature><visual function><whole genome><µfluidic>
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Rima Rachid

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 66/100
Likely hiring
Solid budget
Recent
Active award
$380,000
FY 2026

Project Title

Consortium for food allergy research clinical center CoFar

Grant Number:

5U01AI181964-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/11/2024

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY This CoFAR application brings together seasoned clinical and laboratory investigators in food allergy (FA) with expertise in clinical studies and trials and translational immunologic, microbiome and metabolomic pathways. The investigators have long track records in implementing singl...

Research Terms

<0-11 years old><12 year old><12 years of age><21+ years old><Address><Adult><Adult Human><Affect><Age><Allergic Disease><Allergic Reaction><Allergic to food><Allergy to food><Allergy to peanuts><Anaphylactic Reaction><Anaphylactic Shock><Anaphylaxis><Antigen Receptors><Biological Agent><Biological Products><Blood Serum><Boston><Child><Child Youth><Children (0-21)><Children's Hospital><Clinical><Clinical Investigator><Clinical Research><Clinical Study><Clinical Trials><Clinical Trials Network><Data><Demographic Factors><Development><Disease><Disorder><Dose><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Encapsulated><Epithelial Cells><Epithelium><Ethnic Origin><Ethnicity><Evaluation><FIZZ3><Food><Food Allergy><Food Hypersensitivity><Found in Inflammatory Zone 3><Funding><Future><GI microbiota><Gastrointestinal microbiota><Generations><Goals><Groundnut Hypersensitivity><Gut Epithelium><Human Resources><Immune><Immune Markers><Immune Tolerance><Immune mediated therapy><Immunes><Immunochemical Immunologic><Immunologic><Immunologic Markers><Immunologic Tolerance><Immunological><Immunologically><Immunologically Directed Therapy><Immunologics><Immunotherapy><Infrastructure><Intervention><Investigators><Laboratories><Laboratory Markers><Leadership><Licensing><Life><Manpower><Mediating><Mediator><Mission><Mucosa><Mucosal Tissue><Mucous Membrane><Multi-Institutional Clinical Trial><Multi-center clinical trial><Multi-site clinical trial><Multicenter clinical trial><Multisite clinical trial><NIAID><NIH><National Institute of Allergy and Infectious Disease><National Institutes of Health><Observational Study><Oral><Outcome><Participant><Pathogenesis><Pathway interactions><Patient Recruitments><Patients><Peanut Hypersensitivity><Pediatric Hospitals><Physicians><Placebo Control><Play><Precision therapeutics><Proteins><Quality Control><RETN><Race><Races><Reaction><Receptor Protein><Records><Regulatory T-Lymphocyte><Research><Research Personnel><Researchers><Risk Factors><Role><Safety><Scientist><Seasons><Serum><Services><Site><Solid><Surface><TSLP><TSLP gene><Teen><Teenagers><Testing><Th-2 Cell><Th2 Cells><Therapeutic Clinical Trial><Thymic Stromal Lymphopoietin><Training><Treatment Efficacy><Treg><Type 2 Helper Cell><United States National Institutes of Health><adulthood><age 12><age 12 years><age group><ages><allergen response><allergic reaction to peanut><allergic response><allergic response to peanut><allergic to peanuts><allergy response><biologics><biomarker driven><biomarker identification><biopharmaceutical><biotherapeutic agent><clinical center><cytokine><data management><depository><desensitization><developmental><enteric microbial community><enteric microbiota><experience><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><food allergen><food challenge><fundamental research><gastrointestinal epithelium><gastrointestinal microbial flora><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><high risk><identification of biomarkers><identification of new biomarkers><immune system tolerance><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune unresponsiveness><immune-based biomarkers><immune-based therapies><immune-based treatments><immuno therapy><immunological biomarkers><immunological markers><immunological paralysis><improved><intervention efficacy><intestinal flora><intestinal microbiota><intestinal microflora><intestinal tract microflora><kids><marker identification><meeting><meetings><member><metabolism measurement><metabolomics><metabonomics><microbial consortia><microbial flora><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome transplant><microbiome transplantation><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microbiota transplant><microbiota transplantation><microflora><multispecies consortia><new drug treatments><new drugs><new marker><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation><next generation therapeutics><novel><novel biomarker><novel drug treatments><novel drugs><novel marker><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><observational research study><observational survey><operation><operations><oral immunotherapy><oral tolerance><outcome prediction><participant recruitment><pathway><peanut allergic><peanut allergy><personnel><phase 1 trial><phase 2 trial><phase I trial><phase II trial><placebo controlled><precision therapies><precision treatment><primary outcome><racial><racial background><racial origin><receptor><receptor expression><recruit><regulatory T-cells><repository><resistin><secondary outcome><skills><social role><success><teen years><teenage><therapeutic efficacy><therapy efficacy><translational study><transplant therapy><transplant treatment><transplantation therapy><transplantation treatment><twelve year old><twelve years of age><youngster>
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Casey Michelle Theriot

NORTH CAROLINA STATE UNIVERSITY RALEIGH, RALEIGH, NC

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$380,000
FY 2026

Project Title

The interplay between nutrient availability and secondary bile acid metabolism in commensal Clostridia mediates colonization resistance against C. difficile

Grant Number:

5R35GM149222-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/24/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract In the Theriot laboratory we apply cutting-edge technology and high-throughput methods to analyze the gut microbiome and metabolome using a range of experimental techniques and animal models. We leverage many approaches that span diverse fields including bacterial genetics, ...

Research Terms

<Affect><Amino Acids><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Area><Bacterial Physiology><Basic Research><Basic Science><Bile Acids><Biochemistry><Biological Chemistry><Biological Function><Biological Process><Biomass><C diff><C difficile><C. diff><C. difficile><Clostridioides difficile><Clostridium difficile><Complex><Data><Development><Diet><Disease><Disorder><Environment><Foundations><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Germ-Free><Goals><Gram-Positive Bacteria><Growth><Health><Human><Immune response><In Vitro><Indigenous><Individual><Infection><Intermediary Metabolism><Intestinal><Intestines><Knowledge><Laboratories><Mediating><Metabolic Processes><Metabolism><Methods><Microbe><Microbiomics><Miscellaneous Antibiotic><Mission><Modern Man><NIGMS><NIH><National Institute of General Medical Sciences><National Institutes of Health><Nutrient><Nutrient availability><Prevention><Production><Protein Engineering><Proteins><Proteomics><Public Health><Reproducibility><Reproduction spores><Research><Role><Shapes><Spores><Structure><Techniques><Technology><Therapeutic Intervention><Tissue Growth><United States National Institutes of Health><aminoacid><bacterial genetics><bile acid metabolism><bile metabolism><bowel><colonization resistance><combinatorial><community microbes><design><designing><developmental><diets><digestive tract microbiome><disease diagnosis><enteric microbial community><enteric microbiome><enteric microbiota><gastrointestinal microbial flora><gastrointestinal microbiome><genetic protein engineering><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbe association><host microbe relationship><host response><host-microbe interactions><host-microbial interactions><host-microorganism interactions><immune system response><immunoresponse><improved><in vivo><intervention therapy><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbe community><microbial><microbial community><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microorganism community><model of animal><model organism><mouse model><murine model><novel><ontogeny><pathogen><polymicrobial community><prevent><preventing><protein design><social role><therapeutic agent development><therapeutic development><transcriptomics>
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Corey J. Wilson

GEORGIA INSTITUTE OF TECHNOLOGY, ATLANTA, GA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$370,744
FY 2026

Project Title

Domesticating and Mapping Interactions of the Human Gastrointestinal Microbiome

Grant Number:

5R35GM153457-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Abstract The goal of this work is to develop a universal toolkit to facilitate detailed mapping of interactions within the gastrointestinal (GI) microbiome, and interactions between the GI microbiome and host cells. The successful completion of the proposed research will enable the prescript...

Research Terms

<Actinobacteria><Actinobacteria class><Actinomycetes><Bacteria><Bacteroidetes><Biology><Cell Body><Cells><Code><Coding System><Complex><Decision Making><Development><Ecologic Systems><Ecological Systems><Ecosystem><Evolution><Firmicutes><Functional RNA><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genotype><Goals><Health><Hereditary><High G+C Gram-Positive Bacteria><Horizontal Gene Transfer><Human><Inherited><Investigation><Investigators><Knowledge><Lateral Gene Transfer><Maps><Memory><Microbe><Modality><Modern Man><Molecular><Noncoding RNA><Nontranslated RNA><Organoids><Outcome><Phenotype><Physiologic><Physiological><Physiology><Process><Regulation><Research><Research Personnel><Researchers><Scientist><Untranslated RNA><Work><community microbes><developmental><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><gain of function><gastrointestinal><gastrointestinal bacteria><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><loss of function><microbe community><microbial><microbial community><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota composition><microorganism community><mimicry><noncoding><novel><operation><operations><polymicrobial community><tool><tool development>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Seth T Walk

MONTANA STATE UNIVERSITY - BOZEMAN, BOZEMAN, MT

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$363,449
FY 2026

Project Title

Mechanisms of arsenic detoxification by the human microbiome

Grant Number:

5R01CA215784-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The proposed project addresses the role of the human microbiome in the detoxifying arsenic following ingestion. Arsenic poisoning is a significant worldwide threat to public health that leads to a variety of human diseases, including cancer. Polymorphisms in genes involved with arse...

Research Terms

<Acute><Address><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Arsenic><Arsenic Compounds><Arsenic Poisoning><Arsenical Neurotoxicity Syndrome><Arsenicals><Autoregulation><Bacteria><Bacterial Genome><Biochemical><Bionomics><Biotransformation><Bladder Cancer><Body Tissues><C57BL/6 Mouse><Cancer Causing Agents><Cancers><Carcinogens><Cephalosporins><Chronic><Clinical><Clinical Pharmacists><Clinical Pharmacology><Code><Coding System><Collaborations><Country><DNA Molecular Biology><Diabetes Mellitus><Disease><Disorder><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Ecology><Engineering><Ensure><Enzyme Gene><Enzymes><Epidemiology><Evaluation><Excretory function><Exposure to><Feces><GI microbiome><Generations><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Polymorphism><Genome engineering><Germ-Free><Glycopeptide Antibiotics><Gnotobiotic><Gnotobiotics><Hepatic Cancer><Homeostasis><Human><Human Microbiome><ICP-MS><Immune response><Immunology><Individual><Individual Differences><Inductively Coupled Plasma Mass Spectrometry><Infection><Ingestion><Interdisciplinary Research><Interdisciplinary Study><Intermediary Metabolism><Knowledge><Link><Liver><Malignant Bladder Neoplasm><Malignant Neoplasms><Malignant Skin Neoplasm><Malignant Tumor><Malignant Tumor of the Bladder><Malignant Tumor of the Lung><Malignant neoplasm of liver><Malignant neoplasm of lung><Malignant neoplasm of urinary bladder><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Metabolic Biotransformation><Metabolic Drug Detoxications><Metabolic Processes><Metabolism><Metabolism of Toxic Agents><Methods><Methylation><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Molecular Biology><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Nervous System Arsenic Poisoning><Oncogens><Opportunistic Infections><Outcome><Oxidation-Reduction><Pathway interactions><Penetrance><Persons><Physiological Homeostasis><Play><Poison><Prevention Guidelines><Production><Productivity><Public Health><Pulmonary Cancer><Pulmonary malignant Neoplasm><Reaction><Recombinant DNA Technology><Redox><Research><Risk><Risk Assessment><Role><Sepsis><Series><Skin Cancer><Technical Expertise><Testing><Time><Tissues><Toxic Chemical><Toxic Substance><Toxic effect><Toxicities><Training><Urinary Bladder Cancer><Urinary Bladder Malignant Tumor><Vancomycin><Vascular Diseases><Vascular Disorder><Walking><Whole Organism><Work><arsenical><arsenics><bioaccumulation><blood vessel disorder><cancer prevention><cancer risk><co-exposures><co-occurring exposure><combined exposure><complex exposure><concurrent exposure><detoxification><diabetes><digestive tract microbiome><disease registry><disease risk><disorder risk><drinking water><enteric microbiome><epidemiologic><epidemiological><excretion><experiment><experimental research><experimental study><experiments><exposure mixture><gastrointestinal microbiome><genetically engineered><gut microbiome><gut-associated microbiome><hepatic body system><hepatic organ system><host response><human disease><human-associated microbiome><immune system response><immunoresponse><in vivo><ingest><insight><inter-individual variability><inter-individual variation><intestinal biome><intestinal microbiome><liver cancer><liver malignancy><lung cancer><malignancy><malignant liver tumor><malignant skin tumor><member><microbial><microbiome><mixed exposure><model organism><mouse model><murine model><neoplasm/cancer><novel><oncogenic agent><oxidation reduction reaction><pathway><polymorphism><programs><protective effect><simultaneous exposures><social role><stool><success><technical skills><toxic compound><vascular dysfunction><vasculopathy>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Qian Wang

MONTANA STATE UNIVERSITY - BOZEMAN, BOZEMAN, MT

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$363,449
FY 2026

Project Title

Mechanisms of arsenic detoxification by the human microbiome

Grant Number:

5R01CA215784-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The proposed project addresses the role of the human microbiome in the detoxifying arsenic following ingestion. Arsenic poisoning is a significant worldwide threat to public health that leads to a variety of human diseases, including cancer. Polymorphisms in genes involved with arse...

Research Terms

<Acute><Address><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Arsenic><Arsenic Compounds><Arsenic Poisoning><Arsenical Neurotoxicity Syndrome><Arsenicals><Autoregulation><Bacteria><Bacterial Genome><Biochemical><Bionomics><Biotransformation><Bladder Cancer><Body Tissues><C57BL/6 Mouse><Cancer Causing Agents><Cancers><Carcinogens><Cephalosporins><Chronic><Clinical><Clinical Pharmacists><Clinical Pharmacology><Code><Coding System><Collaborations><Country><DNA Molecular Biology><Diabetes Mellitus><Disease><Disorder><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Ecology><Engineering><Ensure><Enzyme Gene><Enzymes><Epidemiology><Evaluation><Excretory function><Exposure to><Feces><GI microbiome><Generations><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Polymorphism><Genome engineering><Germ-Free><Glycopeptide Antibiotics><Gnotobiotic><Gnotobiotics><Hepatic Cancer><Homeostasis><Human><Human Microbiome><ICP-MS><Immune response><Immunology><Individual><Individual Differences><Inductively Coupled Plasma Mass Spectrometry><Infection><Ingestion><Interdisciplinary Research><Interdisciplinary Study><Intermediary Metabolism><Knowledge><Link><Liver><Malignant Bladder Neoplasm><Malignant Neoplasms><Malignant Skin Neoplasm><Malignant Tumor><Malignant Tumor of the Bladder><Malignant Tumor of the Lung><Malignant neoplasm of liver><Malignant neoplasm of lung><Malignant neoplasm of urinary bladder><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Metabolic Biotransformation><Metabolic Drug Detoxications><Metabolic Processes><Metabolism><Metabolism of Toxic Agents><Methods><Methylation><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Molecular Biology><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Nervous System Arsenic Poisoning><Oncogens><Opportunistic Infections><Outcome><Oxidation-Reduction><Pathway interactions><Penetrance><Persons><Physiological Homeostasis><Play><Poison><Prevention Guidelines><Production><Productivity><Public Health><Pulmonary Cancer><Pulmonary malignant Neoplasm><Reaction><Recombinant DNA Technology><Redox><Research><Risk><Risk Assessment><Role><Sepsis><Series><Skin Cancer><Technical Expertise><Testing><Time><Tissues><Toxic Chemical><Toxic Substance><Toxic effect><Toxicities><Training><Urinary Bladder Cancer><Urinary Bladder Malignant Tumor><Vancomycin><Vascular Diseases><Vascular Disorder><Walking><Whole Organism><Work><arsenical><arsenics><bioaccumulation><blood vessel disorder><cancer prevention><cancer risk><co-exposures><co-occurring exposure><combined exposure><complex exposure><concurrent exposure><detoxification><diabetes><digestive tract microbiome><disease registry><disease risk><disorder risk><drinking water><enteric microbiome><epidemiologic><epidemiological><excretion><experiment><experimental research><experimental study><experiments><exposure mixture><gastrointestinal microbiome><genetically engineered><gut microbiome><gut-associated microbiome><hepatic body system><hepatic organ system><host response><human disease><human-associated microbiome><immune system response><immunoresponse><in vivo><ingest><insight><inter-individual variability><inter-individual variation><intestinal biome><intestinal microbiome><liver cancer><liver malignancy><lung cancer><malignancy><malignant liver tumor><malignant skin tumor><member><microbial><microbiome><mixed exposure><model organism><mouse model><murine model><neoplasm/cancer><novel><oncogenic agent><oxidation reduction reaction><pathway><polymorphism><programs><protective effect><simultaneous exposures><social role><stool><success><technical skills><toxic compound><vascular dysfunction><vasculopathy>
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Mary Catherine Andorfer

MICHIGAN STATE UNIVERSITY, EAST LANSING, MI

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$335,924
FY 2026

Project Title

Engineering radical enzymes for asymmetric olefin hydroalkylation

Grant Number:

1R35GM162132-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: The synthesis of biologically active molecules through selective C–C bond-forming reactions is central to the discovery of new therapeutics. Though forging C–C bonds is often more challenging at C(sp3)-centers than C(sp2)-centers, especially when new stereocenters emerge, clinical s...

Research Terms

<3-D><3-Dimensional><3D><Acceleration><Alkenes><Amino Acids><Biochemical><Biological><Clinical><Complex><Crude Oil><Engineering><Enzyme Gene><Enzymes><GI microbiome><Generations><Goals><H-bond><Health><Human><Hydrogen Bonding><In Vitro><Medicine><Methods><Microbe><Modern Man><Molecular><Nature><Olefins><Organic Synthesis><Petroleum><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Play><Reaction><Research><Role><Route><Shapes><Substrate Specificity><Therapeutic><Toluene><Variant><Variation><aminoacid><biologic><biophysical approaches><biophysical methodology><biophysical methods><biophysical techniques><design><designing><digestive tract microbiome><drug discovery><enteric microbiome><forging><gastrointestinal microbiome><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><gut microbiome><gut-associated microbiome><hexadecane><innovate><innovation><innovative><intestinal biome><intestinal microbiome><methyl-benzene><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-Native><nonnative><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><petroleum oil><pharmaceutical><pollutant><remediation><scaffold><scaffolding><social role><success><therapeutic agent development><therapeutic development><three dimensional>
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Lisa M Bebell

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$259,027
FY 2026

Project Title

Microbiome-driven immune changes and growth stunting in HIV-exposed uninfected children

Grant Number:

3R01HD112302-04S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/11/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Despite increasing access to antiretroviral therapy (ART) in pregnancy, the >1 million children born annually to pregnant women with HIV (PHIV) who are HIV-exposed but uninfected (HEU) remain at >2-fold higher risk of growth stunting and infectious morbidity than HIV-unexposed children. Though the o...

Research Terms

<0-11 years old><0-4 weeks old><5 year old><5 years of age><7S Gamma Globulin><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Follow-up><Address><Antibodies><Antibody Response><Autoregulation><B blood cells><B cell><B cells><B-Cell Subsets><B-Cells><B-Lymphocyte Subsets><B-Lymphocytes><B-cell><Biological><Birth><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Serum><Blood monocyte><Breast Feeding><Breast Milk><Breastmilk><Caring><Cells Placenta-Tissue><Characteristics><Child><Child Health><Child Youth><Childhood><Children (0-21)><Clinical><Communicable Diseases><Communication><Data><Defect><Development><Diarrhea><Diet><Early Intervention><Early identification><Enrollment><Enteral><Enteric><Environmental Exposure><Epidemiology><Fc Receptor><Feces><Food><Functional Metagenomics><GI microbiome><Generalized Growth><Gestation><Goals><Growth><HIV><HIV disease status><HIV infection status><HIV serostatus><HIV status><HIV1 infection status><HIV1 status><Health><Homeostasis><Human Immunodeficiency Viruses><Human Milk><Human Mother's Milk><IgA><IgG><Immune><Immune response><Immune system><Immunes><Immunity><Immunoglobulin A><Immunoglobulin G><Immunology><Infection><Infectious Diseases><Infectious Disorder><Inflammatory><Infrastructure><Innate Immune Response><Investigators><LAV-HTLV-III><Laboratories><Link><Long-term cohort><Longitudinal cohort><Lymphadenopathy-Associated Virus><Mammary Gland Milk><Marrow monocyte><Maternal Immunity><Maternally-Acquired Immunity><Measures><Metadata><Metagenomics><Microbe><Morbidity><Mother's Milk><Mothers><NIH><National Institutes of Health><Neonatal><Newborn Infant><Newborns><Normal Placentoma><Nutrition><Nutritional status><Organism><Outcome><Parturition><Pathogenicity><Pathway interactions><Physiological Homeostasis><Placenta><Placenta Embryonic Tissue><Placentome><Plasma><Plasma Serum><Play><Pneumonia><Predisposition><Pregnancy><Pregnant Women><Proteobacteria><Public Health><Purple Bacteria><Receptor Protein><Recurrence><Recurrent><Reporting><Research><Research Personnel><Researchers><Resolution><Reticuloendothelial System, Serum, Plasma><Risk><Sampling><Serology><Serum><Shapes><Short-Chain Fatty Acids><Source><Susceptibility><System><T-Cells><T-Lymphocyte><Time><Tissue Growth><Uganda><Umbilical Cord><Umbilical cord structure><United States National Institutes of Health><Vaccination><Viral><Virulence><Virus-HIV><Volatile Fatty Acids><Work><active followup><age 5><age 5 years><anti-microbial><antibody receptor><antibody transfer><antimicrobial><antiretroviral therapy><antiretroviral treatment><biobank><biologic><biorepository><burden of disease><burden of illness><co-morbid><co-morbidity><cohort><comorbidity><data pipeline><developmental><diarrheal disease><diarrheal illness><diets><digestive tract microbiome><disease burden><disease model><disorder model><enroll><enteric microbiome><epidemiologic><epidemiological><expectant mother><expectant women><expecting mother><expecting women><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><five year old><five years of age><follow up><follow-up><followed up><followup><gastrointestinal microbiome><gut microbiome><gut microbiome of infant><gut-associated microbiome><high risk><host response><immune system response><immunization strategy><immunoresponse><improved><improved outcome><individuals who are pregnant><infant gut microbiome><infection recurrence><innovate><innovation><innovative><intestinal biome><intestinal microbiome><kids><living system><maternal milk><meta data><metabolism measurement><metabolomics><metabonomics><microbial><microbiome><microbiome community composition><microbiome composition><microbiome intervention><microbiome species composition><microbiome structure><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><monocyte><mortality><neonate gut microbiome><newborn child><newborn children><newborn gut microbiome><novel><ontogeny><pathobiont><pathogen><pathway><pediatric><peer><people who are pregnant><poor health outcome><pregnant females><pregnant mothers><pregnant people><pregnant populations><prospective><receptor><receptor binding><receptor bound><recurrent infection><recurring infection><reduced health outcome><resolutions><species difference><stool><stool sample><stool specimen><those who are pregnant><thymus derived lymphocyte><vaccination strategy><vaccine response><vaccine responsiveness><vaccine strategy><vaccine-induced response><women who are pregnant><worse health outcome><youngster>
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TYRRELL CONWAY

OKLAHOMA STATE UNIVERSITY STILLWATER, STILLWATER, OK

Good lead · 62/100
Large award
Very recent
Active award
Team-scale grant
$2,105,217
FY 2026

Project Title

Oklahoma Center for Microbiome Research

Grant Number:

5P20GM152333-03

Activity Code:

P20

Mechanism:

Research Centers

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT This Phase I COBRE would create the Oklahoma Center for Microbiome Research (OCMR). The proposed Center of Excellence will foster the careers of up-and-coming scientists in the microbiome field. The goal is to create the intellectual environment necessary to support five Res...

Research Terms

<Acceleration><Address><Adolescent><Adolescent Youth><Aero-digestive Tract><Aerodigestive Tract><Award><COBRE><Center of Biomedical Research Excellence><Centers of Research Excellence><Cherokee Nation><Collaborations><Communities><Dietary Carotenoid><Dihydrohydroxycodeinone><Disease><Disorder><Enhancement Technology><Environment><Faculty><Fostering><Foundations><Funding><GI microbiota><Gastrointestinal microbiota><Goals><Grant><Health><Health Sciences><Human><Human Microbiome><Human Resources><Infrastructure><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Investments><Knowledge><Malignant Cell><Malignant Oral Cavity Neoplasm><Malignant Oral Cavity Tumor><Malignant Oral Neoplasm><Manpower><Mentors><Microbe><Microbiology><Microbiomics><Microviridae><Microvirus><Mission><Modeling><Modern Man><Mouth Cancer><Mouth microbiome><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><Oklahoma><Opiate Addiction><Opiate Dependence><Oral Cancer><Osteopathic><Osteopathic Medicine><Osteopathy><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Phase><Pilot Projects><Postdoc><Postdoctoral Fellow><Protocol><Protocols documentation><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Associate><Research Grants><Research Infrastructure><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Support><Researchers><Resources><Role><Roxicodone><Scientist><Services><Specificity><Standardization><Strategic Planning><System><Thinking><United States National Institutes of Health><Universities><University adminstration><associate faculty><associate professor><bowel inflammation><cancer cell><career><career development><cohort><college><collegiate><commensal flora><commensal microbes><commensal microbiota><commensal microflora><design><designing><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiota><experience><gastrointestinal microbial flora><gut community><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><human-associated microbiome><inflamed bowel><inflamed gut><inflamed intestine><innovate><innovation><innovative><intestinal flora><intestinal inflammation><intestinal microbiota><intestinal microflora><intestinal tract microflora><juvenile><juvenile human><malignant mouth neoplasm><malignant mouth tumor><member><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiota><microflora><mid-career faculty><midcareer faculty><multispecies consortia><opiate withdrawal><opioid addiction><opioid dependence><opioid dependent><opioid detox><opioid detoxification><opioid withdrawal><oral cavity cancer><oral microbiome><pathogen><personnel><pilot study><post-doc><post-doctoral><post-doctoral trainee><professor><recruit><research associates><social role><sound><student mentoring><student-led learning><success><thoughts><tool><viral microbiome><virome>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jose C Clemente

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 62/100
Large award
Very recent
Active award
Team-scale grant
$1,500,000
FY 2026

Project Title

Micro-TeACH (Microbiome Technology and Analytic Center Hub)

Grant Number:

5UC2AR081034-05

Activity Code:

UC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Despite many advances in the field, the pathogenesis of autoimmune and immune-mediated diseases (AIMDs) remains incompletely understood but appears to be multifactorial; genetic and environmental factors are implicated in the aberrant inflammatory responses in many AIMDs, including lupus, ...

Research Terms

<Address><Affect><Assay><Atopic Dermatitis><Atopic Eczema><Atopic Neurodermatitis><Atrophic Arthritis><Autoimmune><Bioassay><Biological Assay><Biological Markers><Biological Response Modifier Therapy><Biological Therapy><Biopsy><Body Tissues><Buccal Cavity><Buccal Cavity Head and Neck><Buccal Mucosa><Cancers><Cavitas Oris><Cell Body><Cell Communication><Cell Interaction><Cell-to-Cell Interaction><Cells><Clinical><Collaborations><Communities><Computer software><Cues><Custom><Data><Democracy><Dermatology><Development><Disease><Disease Pathway><Disorder><Disseminated Neurodermatitis><Drug toxicity><Drugs><Environmental Factor><Environmental Risk Factor><Event><Functional Metagenomics><GI microbiome><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Genes><Genetic><Goals><Growth><Heterogeneity><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Human Microbiome><IMiD><IgA><Immune><Immune Cell Activation><Immune modulatory therapeutic><Immunes><Immunoglobulin A><Individual Differences><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Inflammatory Response><Intervention><Investigation><Investigators><Knowledge Portal><Knowledge base Portal><Knowledgebase Portal><Link><Lupus><Lupus Erythematosus Disseminatus><Malignant Neoplasms><Malignant Tumor><Mediating><Medication><Metadata><Metagenomics><Methods><Methotrexate><Methotrexate Methylaminopterin><Methotrexatum><Metotrexato><Mice><Mice Mammals><Microbe><Microbiomics><Modern Man><Molecular><Mouth><Mouth Mucosa><Mouth microbiome><Murine><Mus><Onset of illness><Oral Mucosa><Oral cavity><Oral mucous membrane structure><Outcome><Pathogenesis><Pathway interactions><Patients><Pharmaceutical Preparations><Phase><Phenotype><Prediction of Response to Therapy><Psoriasis><Psoriasis Arthropathica><Psoriatic Arthritis><Publications><QOL><Quality of life><Research Personnel><Research Resources><Researchers><Resolution><Resources><Rheumatoid Arthritis><Rheumatology><Ribosomal RNA><Role><SLE><Salivary Glands><Sampling><Scientific Publication><Shotguns><Sicca Syndrome><Site><Sjogren's Disease><Sjogren's Syndrome><Sjogrens><Sjögren Syndrome><Skin><Skin Tissue><Software><Surface><Systemic Lupus Erythematosus><Systemic Lupus Erythematous><Systemic Lupus Erythmatosus><Systems Biology><Technology><Therapeutic><Tissue Banks><Tissue Collection><Tissue Growth><Tissue repository><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Variant><Variation><Work><allergic dermatitis><allergic eczema><analyze gene expression><analyze microbiome><autoimmune attack><autoimmune destruction><autoimmune pathogenesis><bio-markers><biologic marker><biological therapeutic><biological treatment><biologically based therapeutics><biomarker><biotherapeutics><biotherapy><clinical phenotype><cohort><community microbes><computer based prediction><customs><cutaneous microbiome><cutaneous tissue><dermal microbiome><developmental><digestive tract microbiome><disease heterogeneity><disease onset><disorder onset><disseminated lupus erythematosus><drug metabolism><drug response prediction><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><early onset><enteric microbiome><environmental risk><epidermal microbiome><experience><field based data><field learning><field study><field test><gastrointestinal microbiome><gene expression analysis><gene expression assay><global gene expression><global transcription profile><gut microbiome><gut-associated microbiome><high dimensionality><human-associated microbiome><immune activation><immune modulating agents><immune modulating drug><immune modulating therapeutics><immune modulatory agents><immune modulatory drugs><immunomodulating agents><immunomodulating drugs><immunomodulator agent><immunomodulator drug><immunomodulator medication><immunomodulator prodrug><immunomodulator therapeutic><immunomodulatory agents><immunomodulatory drugs><immunomodulatory therapeutics><improved><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><interest><intestinal autoinflammation><intestinal biome><intestinal microbiome><malignancy><medical college><medical schools><meta data><metagenome><metatranscriptomics><microbe community><microbial><microbial community><microbial composition><microbial consortia><microbial disease><microbial flora><microbial imbalance><microbiome><microbiome analysis><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><microorganism community><multidisciplinary><multispecies consortia><neoplasm/cancer><new technology><novel><novel technologies><ontogeny><oral microbiome><oral mucosae><oral mucosal><oral tissue><pathway><polymicrobial community><precision medicine><precision-based medicine><predict therapeutic response><predict therapy response><predictive modeling><predictive tools><programs><psoriasiform><psoriatic><rRNA><reconstruction><resolutions><responders and non-responders><responders from non-responders><responders or non-responders><responders versus non-responders><responders vs non-responders><responders/nonresponders><response><response to therapy><response to treatment><rheumatic arthritis><rheumatologist><scRNA sequencing><scRNA-seq><school of medicine><shot gun><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skin biome><skin microbiome><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><systemic lupus erythematosis><therapeutic response><therapy prediction><therapy response><transcriptional profiling><transcriptome><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><xerodermosteosis>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

ADRIANA HEGUY

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 62/100
Large award
Very recent
Active award
Team-scale grant
$1,500,000
FY 2026

Project Title

Micro-TeACH (Microbiome Technology and Analytic Center Hub)

Grant Number:

5UC2AR081034-05

Activity Code:

UC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Despite many advances in the field, the pathogenesis of autoimmune and immune-mediated diseases (AIMDs) remains incompletely understood but appears to be multifactorial; genetic and environmental factors are implicated in the aberrant inflammatory responses in many AIMDs, including lupus, ...

Research Terms

<Address><Affect><Assay><Atopic Dermatitis><Atopic Eczema><Atopic Neurodermatitis><Atrophic Arthritis><Autoimmune><Bioassay><Biological Assay><Biological Markers><Biological Response Modifier Therapy><Biological Therapy><Biopsy><Body Tissues><Buccal Cavity><Buccal Cavity Head and Neck><Buccal Mucosa><Cancers><Cavitas Oris><Cell Body><Cell Communication><Cell Interaction><Cell-to-Cell Interaction><Cells><Clinical><Collaborations><Communities><Computer software><Cues><Custom><Data><Democracy><Dermatology><Development><Disease><Disease Pathway><Disorder><Disseminated Neurodermatitis><Drug toxicity><Drugs><Environmental Factor><Environmental Risk Factor><Event><Functional Metagenomics><GI microbiome><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Genes><Genetic><Goals><Growth><Heterogeneity><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Human Microbiome><IMiD><IgA><Immune><Immune Cell Activation><Immune modulatory therapeutic><Immunes><Immunoglobulin A><Individual Differences><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Inflammatory Response><Intervention><Investigation><Investigators><Knowledge Portal><Knowledge base Portal><Knowledgebase Portal><Link><Lupus><Lupus Erythematosus Disseminatus><Malignant Neoplasms><Malignant Tumor><Mediating><Medication><Metadata><Metagenomics><Methods><Methotrexate><Methotrexate Methylaminopterin><Methotrexatum><Metotrexato><Mice><Mice Mammals><Microbe><Microbiomics><Modern Man><Molecular><Mouth><Mouth Mucosa><Mouth microbiome><Murine><Mus><Onset of illness><Oral Mucosa><Oral cavity><Oral mucous membrane structure><Outcome><Pathogenesis><Pathway interactions><Patients><Pharmaceutical Preparations><Phase><Phenotype><Prediction of Response to Therapy><Psoriasis><Psoriasis Arthropathica><Psoriatic Arthritis><Publications><QOL><Quality of life><Research Personnel><Research Resources><Researchers><Resolution><Resources><Rheumatoid Arthritis><Rheumatology><Ribosomal RNA><Role><SLE><Salivary Glands><Sampling><Scientific Publication><Shotguns><Sicca Syndrome><Site><Sjogren's Disease><Sjogren's Syndrome><Sjogrens><Sjögren Syndrome><Skin><Skin Tissue><Software><Surface><Systemic Lupus Erythematosus><Systemic Lupus Erythematous><Systemic Lupus Erythmatosus><Systems Biology><Technology><Therapeutic><Tissue Banks><Tissue Collection><Tissue Growth><Tissue repository><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Variant><Variation><Work><allergic dermatitis><allergic eczema><analyze gene expression><analyze microbiome><autoimmune attack><autoimmune destruction><autoimmune pathogenesis><bio-markers><biologic marker><biological therapeutic><biological treatment><biologically based therapeutics><biomarker><biotherapeutics><biotherapy><clinical phenotype><cohort><community microbes><computer based prediction><customs><cutaneous microbiome><cutaneous tissue><dermal microbiome><developmental><digestive tract microbiome><disease heterogeneity><disease onset><disorder onset><disseminated lupus erythematosus><drug metabolism><drug response prediction><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><early onset><enteric microbiome><environmental risk><epidermal microbiome><experience><field based data><field learning><field study><field test><gastrointestinal microbiome><gene expression analysis><gene expression assay><global gene expression><global transcription profile><gut microbiome><gut-associated microbiome><high dimensionality><human-associated microbiome><immune activation><immune modulating agents><immune modulating drug><immune modulating therapeutics><immune modulatory agents><immune modulatory drugs><immunomodulating agents><immunomodulating drugs><immunomodulator agent><immunomodulator drug><immunomodulator medication><immunomodulator prodrug><immunomodulator therapeutic><immunomodulatory agents><immunomodulatory drugs><immunomodulatory therapeutics><improved><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><interest><intestinal autoinflammation><intestinal biome><intestinal microbiome><malignancy><medical college><medical schools><meta data><metagenome><metatranscriptomics><microbe community><microbial><microbial community><microbial composition><microbial consortia><microbial disease><microbial flora><microbial imbalance><microbiome><microbiome analysis><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><microorganism community><multidisciplinary><multispecies consortia><neoplasm/cancer><new technology><novel><novel technologies><ontogeny><oral microbiome><oral mucosae><oral mucosal><oral tissue><pathway><polymicrobial community><precision medicine><precision-based medicine><predict therapeutic response><predict therapy response><predictive modeling><predictive tools><programs><psoriasiform><psoriatic><rRNA><reconstruction><resolutions><responders and non-responders><responders from non-responders><responders or non-responders><responders versus non-responders><responders vs non-responders><responders/nonresponders><response><response to therapy><response to treatment><rheumatic arthritis><rheumatologist><scRNA sequencing><scRNA-seq><school of medicine><shot gun><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skin biome><skin microbiome><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><systemic lupus erythematosis><therapeutic response><therapy prediction><therapy response><transcriptional profiling><transcriptome><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><xerodermosteosis>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jose U. Scher

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 62/100
Large award
Very recent
Active award
Team-scale grant
$1,500,000
FY 2026

Project Title

Micro-TeACH (Microbiome Technology and Analytic Center Hub)

Grant Number:

5UC2AR081034-05

Activity Code:

UC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Despite many advances in the field, the pathogenesis of autoimmune and immune-mediated diseases (AIMDs) remains incompletely understood but appears to be multifactorial; genetic and environmental factors are implicated in the aberrant inflammatory responses in many AIMDs, including lupus, ...

Research Terms

<Address><Affect><Assay><Atopic Dermatitis><Atopic Eczema><Atopic Neurodermatitis><Atrophic Arthritis><Autoimmune><Bioassay><Biological Assay><Biological Markers><Biological Response Modifier Therapy><Biological Therapy><Biopsy><Body Tissues><Buccal Cavity><Buccal Cavity Head and Neck><Buccal Mucosa><Cancers><Cavitas Oris><Cell Body><Cell Communication><Cell Interaction><Cell-to-Cell Interaction><Cells><Clinical><Collaborations><Communities><Computer software><Cues><Custom><Data><Democracy><Dermatology><Development><Disease><Disease Pathway><Disorder><Disseminated Neurodermatitis><Drug toxicity><Drugs><Environmental Factor><Environmental Risk Factor><Event><Functional Metagenomics><GI microbiome><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Genes><Genetic><Goals><Growth><Heterogeneity><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Human Microbiome><IMiD><IgA><Immune><Immune Cell Activation><Immune modulatory therapeutic><Immunes><Immunoglobulin A><Individual Differences><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Inflammatory Response><Intervention><Investigation><Investigators><Knowledge Portal><Knowledge base Portal><Knowledgebase Portal><Link><Lupus><Lupus Erythematosus Disseminatus><Malignant Neoplasms><Malignant Tumor><Mediating><Medication><Metadata><Metagenomics><Methods><Methotrexate><Methotrexate Methylaminopterin><Methotrexatum><Metotrexato><Mice><Mice Mammals><Microbe><Microbiomics><Modern Man><Molecular><Mouth><Mouth Mucosa><Mouth microbiome><Murine><Mus><Onset of illness><Oral Mucosa><Oral cavity><Oral mucous membrane structure><Outcome><Pathogenesis><Pathway interactions><Patients><Pharmaceutical Preparations><Phase><Phenotype><Prediction of Response to Therapy><Psoriasis><Psoriasis Arthropathica><Psoriatic Arthritis><Publications><QOL><Quality of life><Research Personnel><Research Resources><Researchers><Resolution><Resources><Rheumatoid Arthritis><Rheumatology><Ribosomal RNA><Role><SLE><Salivary Glands><Sampling><Scientific Publication><Shotguns><Sicca Syndrome><Site><Sjogren's Disease><Sjogren's Syndrome><Sjogrens><Sjögren Syndrome><Skin><Skin Tissue><Software><Surface><Systemic Lupus Erythematosus><Systemic Lupus Erythematous><Systemic Lupus Erythmatosus><Systems Biology><Technology><Therapeutic><Tissue Banks><Tissue Collection><Tissue Growth><Tissue repository><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Variant><Variation><Work><allergic dermatitis><allergic eczema><analyze gene expression><analyze microbiome><autoimmune attack><autoimmune destruction><autoimmune pathogenesis><bio-markers><biologic marker><biological therapeutic><biological treatment><biologically based therapeutics><biomarker><biotherapeutics><biotherapy><clinical phenotype><cohort><community microbes><computer based prediction><customs><cutaneous microbiome><cutaneous tissue><dermal microbiome><developmental><digestive tract microbiome><disease heterogeneity><disease onset><disorder onset><disseminated lupus erythematosus><drug metabolism><drug response prediction><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><early onset><enteric microbiome><environmental risk><epidermal microbiome><experience><field based data><field learning><field study><field test><gastrointestinal microbiome><gene expression analysis><gene expression assay><global gene expression><global transcription profile><gut microbiome><gut-associated microbiome><high dimensionality><human-associated microbiome><immune activation><immune modulating agents><immune modulating drug><immune modulating therapeutics><immune modulatory agents><immune modulatory drugs><immunomodulating agents><immunomodulating drugs><immunomodulator agent><immunomodulator drug><immunomodulator medication><immunomodulator prodrug><immunomodulator therapeutic><immunomodulatory agents><immunomodulatory drugs><immunomodulatory therapeutics><improved><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><interest><intestinal autoinflammation><intestinal biome><intestinal microbiome><malignancy><medical college><medical schools><meta data><metagenome><metatranscriptomics><microbe community><microbial><microbial community><microbial composition><microbial consortia><microbial disease><microbial flora><microbial imbalance><microbiome><microbiome analysis><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><microorganism community><multidisciplinary><multispecies consortia><neoplasm/cancer><new technology><novel><novel technologies><ontogeny><oral microbiome><oral mucosae><oral mucosal><oral tissue><pathway><polymicrobial community><precision medicine><precision-based medicine><predict therapeutic response><predict therapy response><predictive modeling><predictive tools><programs><psoriasiform><psoriatic><rRNA><reconstruction><resolutions><responders and non-responders><responders from non-responders><responders or non-responders><responders versus non-responders><responders vs non-responders><responders/nonresponders><response><response to therapy><response to treatment><rheumatic arthritis><rheumatologist><scRNA sequencing><scRNA-seq><school of medicine><shot gun><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skin biome><skin microbiome><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><systemic lupus erythematosis><therapeutic response><therapy prediction><therapy response><transcriptional profiling><transcriptome><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><xerodermosteosis>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Qibin Qi

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$887,696
FY 2026

Project Title

Blood proteomic signatures of diabetes and gut dysbiosis

Grant Number:

1R01DK143633-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

11/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Summary/Abstract The Hispanic/Latino population, one of the fastest growing segments in the US, is disproportionately affected by type 2 diabetes (T2D), but the underlying mechanisms are largely unknown. There is an urgent need to better understand this phenomenon thus to develop more effective appr...

Research Terms

<Acculturation><Active Follow-up><Address><Adult-Onset Diabetes Mellitus><Affect><Apoptosis><Apoptosis Pathway><Asian><Asian group><Asian individual><Asian people><Asian population><Asians><Atherosclerosis Risk in Communities><Behavioral><Biological><Black><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Blood><Blood Plasma><Blood Reticuloendothelial System><Body Tissues><Causality><Characteristics><Chronic Disease><Chronic Illness><Cluster Analyses><Cluster Analysis><Coronary Artery Risk Development in Young Adults><Coronary Artery Risk Development in Young Adults Study><County><Cultural Assimilation><Data><Development><Diabetes Mellitus><Diabetes prevention><Dysfunction><Environmental Factor><Environmental Risk Factor><Etiology><Functional disorder><GI microbiome><GI microbiota><GTEx><GWA study><GWAS><Gastrointestinal microbiota><Gene Action Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Generations><Genetic><Genomics><Genotype-Tissue Expression Project><Goals><HCHS/SOL Study><HCHS/SOL cohort><High Prevalence><Hispanic><Hispanic Community Health Study/Study of Latinos><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Human><Immune Cell Activation><Impoverished><Individual><Inflammation><Insulin Resistance><Intermediary Metabolism><Intestinal><Intestines><Ketosis-Resistant Diabetes Mellitus><Knowledge><Latino Population><Latino group><Latino individual><Latino people><Latinos><Link><Maturity-Onset Diabetes Mellitus><Measures><Mendelian randomization><Metabolic Processes><Metabolism><Modern Man><Multi-Ethnic Study of Atherosclerosis><NIDDM><Network Analysis><Non-Hispanic><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Nonhispanic><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Not Hispanic or Latino><OGTT><Obesity><Oral Glucose Tolerance Test><Participant><Pathogenesis><Pathway Analysis><Pathway interactions><Physiopathology><Plasma><Plasma Proteins><Plasma Serum><Play><Population><Population Group><Poverty><Process><Programmed Cell Death><Prospective cohort><Proteins><Proteome><Proteomics><Public Health><QTL><Quantitative Trait Loci><Reporting><Research Design><Residencies><Reticuloendothelial System, Serum, Plasma><Risk><Role><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Study Type><T2 DM><T2D><T2DM><Technology><Testing><Tissues><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Validation><active followup><adiposity><adult onset diabetes><biobank><biologic><biorepository><bowel><burden of disease><burden of illness><cartilage link protein><causation><chronic disorder><cohort><corpulence><developmental><diabetes><diabetes risk><digestive tract microbiome><disease burden><disease causation><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><fat metabolism><follow up><follow-up><followed up><followup><gastrointestinal microbial flora><gastrointestinal microbiome><gene function><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><high risk group><high risk individual><high risk people><high risk population><immune activation><improved><insight><insulin resistant><insulin secretion><insulin tolerance><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><ketosis resistant diabetes><link protein><lipid metabolism><maturity onset diabetes><microbial><microbial consortia><microbial flora><microbiome><microbiota><microflora><multi-ethnic><multiethnic><multiomics><multiple omics><multispecies consortia><neural network><novel><panomics><pathophysiology><pathway><prevent><preventing><proteomic signature><social culture><social role><socio-cultural><sociocultural><statistics><study design><trait><transcriptomics><type 2 DM><type II DM><type two diabetes><validations><whole genome association analysis><whole genome association study>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Bing Yu

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$887,696
FY 2026

Project Title

Blood proteomic signatures of diabetes and gut dysbiosis

Grant Number:

1R01DK143633-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

11/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Summary/Abstract The Hispanic/Latino population, one of the fastest growing segments in the US, is disproportionately affected by type 2 diabetes (T2D), but the underlying mechanisms are largely unknown. There is an urgent need to better understand this phenomenon thus to develop more effective appr...

Research Terms

<Acculturation><Active Follow-up><Address><Adult-Onset Diabetes Mellitus><Affect><Apoptosis><Apoptosis Pathway><Asian><Asian group><Asian individual><Asian people><Asian population><Asians><Atherosclerosis Risk in Communities><Behavioral><Biological><Black><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Blood><Blood Plasma><Blood Reticuloendothelial System><Body Tissues><Causality><Characteristics><Chronic Disease><Chronic Illness><Cluster Analyses><Cluster Analysis><Coronary Artery Risk Development in Young Adults><Coronary Artery Risk Development in Young Adults Study><County><Cultural Assimilation><Data><Development><Diabetes Mellitus><Diabetes prevention><Dysfunction><Environmental Factor><Environmental Risk Factor><Etiology><Functional disorder><GI microbiome><GI microbiota><GTEx><GWA study><GWAS><Gastrointestinal microbiota><Gene Action Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Generations><Genetic><Genomics><Genotype-Tissue Expression Project><Goals><HCHS/SOL Study><HCHS/SOL cohort><High Prevalence><Hispanic><Hispanic Community Health Study/Study of Latinos><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Human><Immune Cell Activation><Impoverished><Individual><Inflammation><Insulin Resistance><Intermediary Metabolism><Intestinal><Intestines><Ketosis-Resistant Diabetes Mellitus><Knowledge><Latino Population><Latino group><Latino individual><Latino people><Latinos><Link><Maturity-Onset Diabetes Mellitus><Measures><Mendelian randomization><Metabolic Processes><Metabolism><Modern Man><Multi-Ethnic Study of Atherosclerosis><NIDDM><Network Analysis><Non-Hispanic><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Nonhispanic><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Not Hispanic or Latino><OGTT><Obesity><Oral Glucose Tolerance Test><Participant><Pathogenesis><Pathway Analysis><Pathway interactions><Physiopathology><Plasma><Plasma Proteins><Plasma Serum><Play><Population><Population Group><Poverty><Process><Programmed Cell Death><Prospective cohort><Proteins><Proteome><Proteomics><Public Health><QTL><Quantitative Trait Loci><Reporting><Research Design><Residencies><Reticuloendothelial System, Serum, Plasma><Risk><Role><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Study Type><T2 DM><T2D><T2DM><Technology><Testing><Tissues><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Validation><active followup><adiposity><adult onset diabetes><biobank><biologic><biorepository><bowel><burden of disease><burden of illness><cartilage link protein><causation><chronic disorder><cohort><corpulence><developmental><diabetes><diabetes risk><digestive tract microbiome><disease burden><disease causation><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><fat metabolism><follow up><follow-up><followed up><followup><gastrointestinal microbial flora><gastrointestinal microbiome><gene function><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><high risk group><high risk individual><high risk people><high risk population><immune activation><improved><insight><insulin resistant><insulin secretion><insulin tolerance><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><ketosis resistant diabetes><link protein><lipid metabolism><maturity onset diabetes><microbial><microbial consortia><microbial flora><microbiome><microbiota><microflora><multi-ethnic><multiethnic><multiomics><multiple omics><multispecies consortia><neural network><novel><panomics><pathophysiology><pathway><prevent><preventing><proteomic signature><social culture><social role><socio-cultural><sociocultural><statistics><study design><trait><transcriptomics><type 2 DM><type II DM><type two diabetes><validations><whole genome association analysis><whole genome association study>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Tal Korem

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$825,395
FY 2026

Project Title

Microbial biomarkers of intestinal MDR colonization after solid organ transplantation

Grant Number:

5R01AI183668-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/2/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Novel approaches are needed to tackle the increasing global public health threat of antimicrobial resistance (AMR). Multi-drug resistant organisms (MDRO), such as Enterobacterales resistant to carbapenems (CRE), extended spectrum beta-lactamases (ESBL) and vancomycin-resistant Enterococci (...

Research Terms

<Active Follow-up><Address><Affect><Algorithms><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Antimicrobial Resistance><Bacteriophages><Biological Markers><Carbapenem resistance in Enterobacterales><Cardiac Transplantation><Characteristics><Clinical><Clinical Management><Collection><Complex><Data><Data Analyses><Data Analysis><Development><Disease><Disorder><Ecologic Systems><Ecological Systems><Ecosystem><Event><Extended-spectrum beta-lactamase><Extended-spectrum β-lactamase><Functional Metagenomics><Future><GI colonization><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Taxonomy><Generalized Growth><Genes><Genomics><Grafting Procedure><Growth><Heart><Heart Grafting><Heart Transplantation><Hepatic Transplantation><Horizontal Gene Transfer><Hospitals><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><Individual><Infection><Intervention><Intestinal><Intestines><Joints><Kidney><Kidney Grafting><Kidney Transplantation><Kidney Transplants><Kidney Urinary System><Lateral Gene Transfer><Link><Liver><Liver Grafting><Liver Transplant><MDR organism><MDR pathogen><Machine Learning><Measures><Medical><Metagenomics><Methods><Miscellaneous Antibiotic><Modeling><Morbidity><Operon><Organ Transplantation><Organ Transplants><Outcome><Patients><Phages><Population><Predicting Risk><Predictive Factor><Property><Prophylactic treatment><Prophylaxis><Public Health><Renal Grafting><Renal Transplantation><Renal Transplants><Research><Resistance><Resistance to antibiotics><Resistant to antibiotics><Resolution><Risk><Risk Factors><Risk Management><Sampling><Solid><Source><Subgroup><Systemic infection><Taxonomy><Testing><Therapeutic><Time><Tissue Growth><Transmission><Transplant Recipients><Treatment Protocols><Treatment Regimen><Treatment Schedule><Validation><Vancomycin resistant enterococcus><Vancomycin-resistant enterococci><Work><active followup><adverse consequence><adverse outcome><anti-microbial resistance emergence><anti-microbial resistant><antibiotic drug resistance><antibiotic resistant><antimicrobial resistance emergence><bacterial disease treatment><bacterial infectious disease treatment><bacterial virus><bio-markers><biobank><biologic marker><biomarker><biomarker identification><biorepository><bowel><carbapenem resistance><carbapenem resistant><carbapenem resistant Enterobacterales><carbapenem resistant Enterobacteriales><cardiac graft><clinical decision-making><clinical predictors><clinical sequencing><cohort><computer based prediction><data interpretation><developmental><digestive tract microbiome><effective therapy><effective treatment><emerging anti-microbial resistance><emerging antimicrobial resistance><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><experience><follow up><follow-up><followed up><followup><forecasting risk><full genome><gastrointestinal><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><genome sequencing><genomic variation><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heart transplant><hepatic body system><hepatic organ system><high risk><identification of biomarkers><identification of new biomarkers><immunosuppressed patient><improved><infection risk><intestinal biome><intestinal colonization><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kidney tx><liver transplantation><long read seq><long-read sequencing><long-read transcript sequencing><machine based learning><machine learning based model><machine learning based prediction model><machine learning based predictive model><machine learning model><machine learning prediction><machine learning prediction model><marker identification><metagenome><metagenome sequencing><metagenomic sequencing><microbial><microbial signature><microbiome><mortality><multi-drug resistant organism><multi-drug resistant pathogen><multidrug resistant organism><multidrug resistant pathogen><multiple drug resistant organism><multiple drug resistant pathogen><new approaches><novel><novel approaches><novel strategies><novel strategy><ontogeny><organ allograft><organ graft><organ transplant patient><organ transplant recipient><organ xenograft><patient population><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive modeling><predictive risk><predictive signature><predicts risk><prevent><preventing><renal><resistance against carbapenems><resistance gene><resistance locus><resistance to anti-microbial><resistance to carbapenem><resistant><resistant gene><resistant to antimicrobial><resistant to carbapenem><resolutions><risk prediction><risk predictions><therapeutic target><tool><transmission process><transplant patient><treatment strategy><validations><vancomycin resistance enterococci><vancomycin resistance in enterococci><whole genome>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Anne-Catrin Uhlemann

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$825,395
FY 2026

Project Title

Microbial biomarkers of intestinal MDR colonization after solid organ transplantation

Grant Number:

5R01AI183668-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/2/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Novel approaches are needed to tackle the increasing global public health threat of antimicrobial resistance (AMR). Multi-drug resistant organisms (MDRO), such as Enterobacterales resistant to carbapenems (CRE), extended spectrum beta-lactamases (ESBL) and vancomycin-resistant Enterococci (...

Research Terms

<Active Follow-up><Address><Affect><Algorithms><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Antimicrobial Resistance><Bacteriophages><Biological Markers><Carbapenem resistance in Enterobacterales><Cardiac Transplantation><Characteristics><Clinical><Clinical Management><Collection><Complex><Data><Data Analyses><Data Analysis><Development><Disease><Disorder><Ecologic Systems><Ecological Systems><Ecosystem><Event><Extended-spectrum beta-lactamase><Extended-spectrum β-lactamase><Functional Metagenomics><Future><GI colonization><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Taxonomy><Generalized Growth><Genes><Genomics><Grafting Procedure><Growth><Heart><Heart Grafting><Heart Transplantation><Hepatic Transplantation><Horizontal Gene Transfer><Hospitals><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><Individual><Infection><Intervention><Intestinal><Intestines><Joints><Kidney><Kidney Grafting><Kidney Transplantation><Kidney Transplants><Kidney Urinary System><Lateral Gene Transfer><Link><Liver><Liver Grafting><Liver Transplant><MDR organism><MDR pathogen><Machine Learning><Measures><Medical><Metagenomics><Methods><Miscellaneous Antibiotic><Modeling><Morbidity><Operon><Organ Transplantation><Organ Transplants><Outcome><Patients><Phages><Population><Predicting Risk><Predictive Factor><Property><Prophylactic treatment><Prophylaxis><Public Health><Renal Grafting><Renal Transplantation><Renal Transplants><Research><Resistance><Resistance to antibiotics><Resistant to antibiotics><Resolution><Risk><Risk Factors><Risk Management><Sampling><Solid><Source><Subgroup><Systemic infection><Taxonomy><Testing><Therapeutic><Time><Tissue Growth><Transmission><Transplant Recipients><Treatment Protocols><Treatment Regimen><Treatment Schedule><Validation><Vancomycin resistant enterococcus><Vancomycin-resistant enterococci><Work><active followup><adverse consequence><adverse outcome><anti-microbial resistance emergence><anti-microbial resistant><antibiotic drug resistance><antibiotic resistant><antimicrobial resistance emergence><bacterial disease treatment><bacterial infectious disease treatment><bacterial virus><bio-markers><biobank><biologic marker><biomarker><biomarker identification><biorepository><bowel><carbapenem resistance><carbapenem resistant><carbapenem resistant Enterobacterales><carbapenem resistant Enterobacteriales><cardiac graft><clinical decision-making><clinical predictors><clinical sequencing><cohort><computer based prediction><data interpretation><developmental><digestive tract microbiome><effective therapy><effective treatment><emerging anti-microbial resistance><emerging antimicrobial resistance><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><experience><follow up><follow-up><followed up><followup><forecasting risk><full genome><gastrointestinal><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><genome sequencing><genomic variation><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heart transplant><hepatic body system><hepatic organ system><high risk><identification of biomarkers><identification of new biomarkers><immunosuppressed patient><improved><infection risk><intestinal biome><intestinal colonization><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kidney tx><liver transplantation><long read seq><long-read sequencing><long-read transcript sequencing><machine based learning><machine learning based model><machine learning based prediction model><machine learning based predictive model><machine learning model><machine learning prediction><machine learning prediction model><marker identification><metagenome><metagenome sequencing><metagenomic sequencing><microbial><microbial signature><microbiome><mortality><multi-drug resistant organism><multi-drug resistant pathogen><multidrug resistant organism><multidrug resistant pathogen><multiple drug resistant organism><multiple drug resistant pathogen><new approaches><novel><novel approaches><novel strategies><novel strategy><ontogeny><organ allograft><organ graft><organ transplant patient><organ transplant recipient><organ xenograft><patient population><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive modeling><predictive risk><predictive signature><predicts risk><prevent><preventing><renal><resistance against carbapenems><resistance gene><resistance locus><resistance to anti-microbial><resistance to carbapenem><resistant><resistant gene><resistant to antimicrobial><resistant to carbapenem><resolutions><risk prediction><risk predictions><therapeutic target><tool><transmission process><transplant patient><treatment strategy><validations><vancomycin resistance enterococci><vancomycin resistance in enterococci><whole genome>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

PHILLIP SCOTT

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$793,161
FY 2026

Project Title

Deciphering the ontogeny of CD4+ resident memory T cells that globally seed the skin and protect against cutaneous leishmaniasis

Grant Number:

5R01AI189513-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Dermal resident memory CD4+ T cells (dTrm) are uniquely positioned to protect against vector-borne pathogens such as Leishmania major. However, despite their significance, the ontogeny of dTrm cells and the influence of the skin microbiome and T cell intrinsic signals that promote their retention fo...

Research Terms

<Adoptive Transfer><Antibiotic Therapy><Antibiotic Treatment><Antibodies><Antigenic Determinants><Antigens><Automobile Driving><Bacteria><Basal Transcription Factor><Basal transcription factor genes><Binding Determinants><Body Tissues><CD54 Antigens><CD62E Antigens><CITE sequencing><CITE-seq><CITEseq><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CSIF><CSIF-10><CXCR><Cas nuclease technology><Cell Adhesion Molecule E-Selectin><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Mediated Immunology><Cell Signaling><Cell-Mediated Immunity><Cells><Cellular Immunity><Cellular Indexing of Transcriptomes and Epitopes by Sequencing><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Comparative Study><Curiosities><Cutaneous><Cutaneous Disorder><Cutaneous Leishmaniasis><Cytokine Synthesis Inhibitory Factor><Dermal><Dermatoses><Development><Disease><Disorder><Distal><Drugs><E-Selectin><ELAM-1><Ectopic Expression><Edodekin Alfa><Endothelial Adhesion Molecule 1><Endothelial Leukocyte Adhesion Molecule-1><Epitopes><Expression Signature><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Frequencies><GI microbiome><Gene Deletion><Gene Expression><Gene Expression Profile><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Germ-Free><Goals><Growth><Hepatic><Homing><ICAM-1><IL-10><IL-12><IL-12 receptor><IL-12R><IL10><IL10A><IL12><Immune><Immunes><Immunization><Immunize><Infection><Inflammatory><Intercellular adhesion molecule 1><Interleukin 10 Precursor><Interleukin-10><Interleukin-12><Intracellular Communication and Signaling><Intramuscular><LECAM-2><Leishmania (Leishmania) major><Leishmania major><Leishmania tropica major><Leishmaniasis><Leukocyte Endothelial Cell Adhesion Molecule 2><Ligands><Mediating><Medication><Messenger RNA><Mice><Mice Mammals><Microbe><Murine><Mus><NKSF><Natural Killer Cell Stimulatory Factor><PEPCK><Peptide Vaccines><Peptides><Pharmaceutical Preparations><Phosphoenolpyruvate Carboxylase><Play><Population><Position><Positioning Attribute><Primary Infection><Proteins><RNA vaccine><RNA-based vaccine><Recombinant DNA Technology><Role><Route><Signal Transduction><Signal Transduction Systems><Signaling><Site><Skin><Skin Diseases><Skin Diseases and Manifestations><Skin colonization><T cell response><T memory cell><T-Cell Development><T-Cell Ontogeny><T-Cells><T-Lymphocyte><T-Lymphocyte Development><Technology><Testing><Tissue Growth><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Vaccination><Vaccines><Vector-borne disease><Vector-borne infectious disease><Vector-transmitted disease><Vector-transmitted infectious disease><bacterial disease treatment><bacterial infectious disease treatment><biological signal transduction><cellular development><cellular indexing of transcriptomes and epitopes by single cell sequencing><comparative><cutaneous disease><cutaneous lesions><cutaneous microbiome><cutaneous microbiota><cytokine><dermal disease><dermal disorder><dermal leishmaniasis><dermal lesion><dermal microbiome><dermal microbiota><develop a vaccine><develop vaccines><development of a vaccine><developmental><digestive tract microbiome><draining lymph node><driving><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><endothelial leukocyte adhesion molecule><enteric microbiome><epidermal microbiome><flow cytophotometry><gastrointestinal microbiome><gene deletion mutation><gene expression pattern><gene expression signature><gene signatures><genetic signature><genetically engineered><global gene expression><global transcription profile><gut microbiome><gut-associated microbiome><healing><immunogen><in vivo><indexing><interleukin-12 receptor><intestinal biome><intestinal microbiome><lipid based nanoparticle><lipid nanoparticle><mRNA><mRNA lipid nano particle vaccine><mRNA vaccine><mRNA-LNP based vaccine><mRNA-LNP combination vaccines><mRNA-LNP vaccines><mRNA-based vaccine><memory CD4 T cell><memory CD4 T lymphocyte><memory T lymphocyte><microbial imbalance><microbiome><mouse model><murine model><nano particle delivery><nanoparticle delivered><nanoparticle delivery><neglect><neglected tropical diseases><novel><ontogeny><peptide based vaccine><phosphoenolpyruvate carboxykinase><recruit><regional lymph node><resident memory T cell><response><retroviral transduction><skin biome><skin disorder><skin flora><skin lesion><skin microbial community><skin microbiome><skin microbiota><skin microflora><social role><thymus derived lymphocyte><tissue resident memory T cell><transcription factor><transcriptional profile><transcriptional signature><transcriptome><vaccine development><vaccine response><vaccine responsiveness><vaccine strategy><vaccine-induced response><vector-borne illness><vector-borne pathogen><vectorborne disease><vectorborne illness><vectorborne infectious disease><vectorborne pathogen>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Robert C Kaplan

UNIVERSITY OF MASSACHUSETTS LOWELL, LOWELL, MA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$769,275
FY 2026

Project Title

Microbiome and AD/ADRD Risk in SOL

Grant Number:

5R01AG085320-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Alzheimer’s disease and related dementias (AD/ADRD) is a growing public health burden, further accentuated by the rapid aging of the US population and increased life expectancy. The gut microbiome, sometimes called the ‘second brain’ engages in bi-directional communication w...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><AD therapy><AD treatment><ADRD><Address><Aging><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's amyloid><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's therapy><Alzheimers Dementia><Amentia><Aminalon><Aminalone><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Astroprotein><Automobile Driving><Aβ><B fragilis><B. fragilis><Bacteria><Bacteroides fragilis><Bifidobacterium><Bile Acids><Biological Markers><Blood Plasma><Blood Serum><Blood Vessels><Brain><Brain Nervous System><Branched-Chain Amino Acids><CNS Nervous System><Central Nervous System><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><D-Glucose><Data><Data Bases><Databases><Dementia><Dextrose><Diabetes Mellitus><Diagnosis><Diet><Disparity population><Disturbance in cognition><Drugs><Early Diagnosis><Encephalon><Enterotoxins><Escherichia><Fasting><Fatty Acid Metabolism Pathway><Feces><Functional Metagenomics><Future><GABA><GFA-Protein><GFAP><GI microbiome><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Glucose><Glycohemoglobin A><Glycosylated hemoglobin A><Goals><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Hemoglobin A(1)><High Prevalence><Human><Humulin R><Impaired cognition><Individual><Inflammation><Inflammatory><Insulin><Intermediary Metabolism><Isoleucine><L-Tryptophan><L-Valine><Laboratories><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Leucine><Levotryptophan><Life Expectancy><Light><Link><Lipopolysaccharides><Longitudinal Studies><Longitudinal Surveys><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Metabolic><Metabolic Processes><Metabolism><Metagenomics><Microbiomics><Modern Man><NMR Imaging><NMR Tomography><Nerve Degeneration><Neuraxis><Neuron Degeneration><Novolin R><Nuclear Magnetic Resonance Imaging><Outcome><Participant><Pharmaceutical Preparations><Photoradiation><Physical activity><Plasma><Plasma Serum><Population><Prevention><Primary Senile Degenerative Dementia><Production><Psychosocial Factor><Public Health><Regular Insulin><Reticuloendothelial System, Serum, Plasma><Risk Factors><Role><Sample Size><Serum><Shigella><Short-Chain Fatty Acids><Stimulus><Study of Latinos><Time><Tryptophan><Valine><Volatile Fatty Acids><Work><Zeugmatography><a beta peptide><abeta><abeta accumulation><abeta aggregation><alzheimer risk><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid β accumulation><amyloid β aggregation><amyloid-b protein><aβ accumulation><aβ aggregation><beta amyloid fibril><bio-markers><biologic marker><biomarker><brain MR imaging><brain MRI><brain magnetic resonance imaging><branched amino acids><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><cognitive dysfunction><cognitive function><cognitive loss><cohort><data base><dementia risk><design><designing><diabetes><diets><digestive tract microbiome><disadvantaged group><disadvantaged individual><disadvantaged people><disadvantaged population><disadvantaged subgroup><disparities across groups><disparity across subgroups><disparity among groups><disparity among subgroups><disparity between groups><disparity between subgroups><disparity in health><driving><drug/agent><early detection><endophenotype><enteric microbiome><fasted><fasts><fatty acid metabolism><gamma-Aminobutyric Acid><gastrointestinal microbiome><gene function><glycemic control><group disparity><group inequality><group inequity><gut microbiome><gut-associated microbiome><health disparity><hemoglobin A1c><high risk><high risk group><high risk individual><high risk people><high risk population><hyper-phosphorylated tau><hyperphosphorylated tau><improved><inequalities among populations><inequalities between populations><inequalities in populations><inequality across populations><inequality among groups><inequality between groups><inequality in groups><inequities among populations><inequities between populations><inequities in populations><inequity across groups><inequity across populations><inequity between groups><inequity in groups><insight><interest><intestinal biome><intestinal microbiome><long-term study><longitudinal outcome studies><longitudinal research study><metabolism measurement><metabolomics><metabonomics><microbial><microbiome><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microtubule bound tau><microtubule-bound tau><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><multiomics><multiple omics><neural degeneration><neural inflammation><neurocognitive test><neurodegeneration><neurodegenerative><neurofilament><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal degeneration><panomics><population inequality><population inequity><pre-clinical><precision medicine><precision-based medicine><preclinical><primary degenerative dementia><psychosocial variables><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social factors><social role><soluble amyloid precursor protein><stool><subgroup disparity><tau><tau Proteins><tau factor><translational impact><unequal group><unequal population><vascular><γ-Aminobutyric Acid><τ Proteins>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Natalia Palacios

UNIVERSITY OF MASSACHUSETTS LOWELL, LOWELL, MA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$769,275
FY 2026

Project Title

Microbiome and AD/ADRD Risk in SOL

Grant Number:

5R01AG085320-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Alzheimer’s disease and related dementias (AD/ADRD) is a growing public health burden, further accentuated by the rapid aging of the US population and increased life expectancy. The gut microbiome, sometimes called the ‘second brain’ engages in bi-directional communication w...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><AD therapy><AD treatment><ADRD><Address><Aging><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's amyloid><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's therapy><Alzheimers Dementia><Amentia><Aminalon><Aminalone><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Astroprotein><Automobile Driving><Aβ><B fragilis><B. fragilis><Bacteria><Bacteroides fragilis><Bifidobacterium><Bile Acids><Biological Markers><Blood Plasma><Blood Serum><Blood Vessels><Brain><Brain Nervous System><Branched-Chain Amino Acids><CNS Nervous System><Central Nervous System><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><D-Glucose><Data><Data Bases><Databases><Dementia><Dextrose><Diabetes Mellitus><Diagnosis><Diet><Disparity population><Disturbance in cognition><Drugs><Early Diagnosis><Encephalon><Enterotoxins><Escherichia><Fasting><Fatty Acid Metabolism Pathway><Feces><Functional Metagenomics><Future><GABA><GFA-Protein><GFAP><GI microbiome><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Glucose><Glycohemoglobin A><Glycosylated hemoglobin A><Goals><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Hemoglobin A(1)><High Prevalence><Human><Humulin R><Impaired cognition><Individual><Inflammation><Inflammatory><Insulin><Intermediary Metabolism><Isoleucine><L-Tryptophan><L-Valine><Laboratories><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Leucine><Levotryptophan><Life Expectancy><Light><Link><Lipopolysaccharides><Longitudinal Studies><Longitudinal Surveys><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Metabolic><Metabolic Processes><Metabolism><Metagenomics><Microbiomics><Modern Man><NMR Imaging><NMR Tomography><Nerve Degeneration><Neuraxis><Neuron Degeneration><Novolin R><Nuclear Magnetic Resonance Imaging><Outcome><Participant><Pharmaceutical Preparations><Photoradiation><Physical activity><Plasma><Plasma Serum><Population><Prevention><Primary Senile Degenerative Dementia><Production><Psychosocial Factor><Public Health><Regular Insulin><Reticuloendothelial System, Serum, Plasma><Risk Factors><Role><Sample Size><Serum><Shigella><Short-Chain Fatty Acids><Stimulus><Study of Latinos><Time><Tryptophan><Valine><Volatile Fatty Acids><Work><Zeugmatography><a beta peptide><abeta><abeta accumulation><abeta aggregation><alzheimer risk><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid β accumulation><amyloid β aggregation><amyloid-b protein><aβ accumulation><aβ aggregation><beta amyloid fibril><bio-markers><biologic marker><biomarker><brain MR imaging><brain MRI><brain magnetic resonance imaging><branched amino acids><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><cognitive dysfunction><cognitive function><cognitive loss><cohort><data base><dementia risk><design><designing><diabetes><diets><digestive tract microbiome><disadvantaged group><disadvantaged individual><disadvantaged people><disadvantaged population><disadvantaged subgroup><disparities across groups><disparity across subgroups><disparity among groups><disparity among subgroups><disparity between groups><disparity between subgroups><disparity in health><driving><drug/agent><early detection><endophenotype><enteric microbiome><fasted><fasts><fatty acid metabolism><gamma-Aminobutyric Acid><gastrointestinal microbiome><gene function><glycemic control><group disparity><group inequality><group inequity><gut microbiome><gut-associated microbiome><health disparity><hemoglobin A1c><high risk><high risk group><high risk individual><high risk people><high risk population><hyper-phosphorylated tau><hyperphosphorylated tau><improved><inequalities among populations><inequalities between populations><inequalities in populations><inequality across populations><inequality among groups><inequality between groups><inequality in groups><inequities among populations><inequities between populations><inequities in populations><inequity across groups><inequity across populations><inequity between groups><inequity in groups><insight><interest><intestinal biome><intestinal microbiome><long-term study><longitudinal outcome studies><longitudinal research study><metabolism measurement><metabolomics><metabonomics><microbial><microbiome><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microtubule bound tau><microtubule-bound tau><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><multiomics><multiple omics><neural degeneration><neural inflammation><neurocognitive test><neurodegeneration><neurodegenerative><neurofilament><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal degeneration><panomics><population inequality><population inequity><pre-clinical><precision medicine><precision-based medicine><preclinical><primary degenerative dementia><psychosocial variables><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social factors><social role><soluble amyloid precursor protein><stool><subgroup disparity><tau><tau Proteins><tau factor><translational impact><unequal group><unequal population><vascular><γ-Aminobutyric Acid><τ Proteins>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Nancie MacIver

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$753,296
FY 2026

Project Title

Identifying mechanisms by which metformin regulates T cell responses in obesity

Grant Number:

5R01DK139107-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/20/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Obesity is associated with chronic inflammation and an impaired immune response to infection from select viruses, including influenza and SARS-CoV-2, leading to increased morbidity and mortality. Many studies have demonstrated a critical role for CD4+ and CD8+ T cells in this setting...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><3'5'-cyclic ester of AMP><3,5 cyclic AMP synthetase><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine Receptors><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adenyl Cyclase><Adenylate Cyclase><Adenylyl Cyclase><Adipose tissue><Affect><Animals><Attenuated><Blood Serum><Body Tissues><Body Weight decreased><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><COVID-19><COVID-19 virus><COVID19 virus><CV-19><Caloric Restriction><Cell Body><Cell Function><Cell Isolation><Cell Physiology><Cell Process><Cell Respiration><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Cellular Function><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Cellular Respiration><Chronic><CoV-2><CoV2><Communicable Diseases><Coronaviridae><Coronavirus><Coronavirus Infectious Disease 2019><Cryofixation><Cryopreservation><Cyclic AMP><Data><Diabetes Mellitus><Dimethylbiguanidine><Dimethylguanylguanidine><Disease><Disorder><Drugs><Dysfunction><Equilibrium><Eragrostis><Fatty Tissue><Functional disorder><Funding><G-Proteins><GI microbiome><GTP-Binding Proteins><GTP-Regulatory Proteins><Grippe><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><High Prevalence><History><Human><Immune><Immune response><Immunes><Impairment><In Vitro><Infection><Infectious Diseases><Infectious Disorder><Inflammation><Inflammatory><Influenza><Influenza Virus><Leanness><Link><Medication><Memory><Metabolic dysfunction><Metformin><Mice><Mice Mammals><Mitochondria><Modern Man><Molecular><Monitor><Morbidity><Murine><Mus><N,N-dimethyl-imidodicarbonimidic diamide><NIH><National Institutes of Health><Obese Mice><Obesity><Observational Study><Orthocoronavirinae><Outcome><P1 Purinoceptors><PBMC><Patients><Peripheral Blood Mononuclear Cell><Pharmaceutical Preparations><Physiopathology><Production><Purinergic P1 Receptors><Receptor Signaling><Recording of previous events><Regulatory T-Lymphocyte><Retrospective Studies><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sampling><Serum><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Severity of illness><Signal Induction><Subcellular Process><T cell response><T memory cell><T-Cell Activation><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><T8 Cells><T8 Lymphocytes><Teff><Teff cell><Testing><Thinness><Tissues><Treg><United States National Institutes of Health><Viral Diseases><Virus><Virus Diseases><Vulnerable Populations><Weight><Weight Loss><Weight Reduction><Wuhan coronavirus><activate T cells><adenosine 3'5' monophosphate><adipose><adiposity><aerobic metabolism><aerobic respiration><attenuate><attenuates><balance><balance function><bariatric surgery><biobank><biorepository><body weight loss><cAMP><calorie restriction><cell metabolism><cell sorting><cellular metabaolism><clinical relevance><clinically relevant><cold preservation><cold storage><corona virus><coronavirus disease 2019><coronavirus disease 2019 virus><coronavirus disease-19><coronavirus disease-19 virus><coronavirus infectious disease-19><corpulence><cytokine><diabetes><digestive tract microbiome><disease severity><drug discovery><drug/agent><effector T cell><enteric microbiome><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><flu infection><flu virus infection><flu virus pandemic><gastric banding><gastric bypass surgery><gastrointestinal microbiome><glucose uptake><gut microbiome><gut-associated microbiome><hCoV19><high risk group><high risk individual><high risk people><high risk population><histories><host response><human subject><immune system response><immunoresponse><implantable gastric stimulation banding><improved><infected with flu><infected with flu virus><infected with influenza><infected with influenza virus><influenza infection><influenza virus infection><influenza virus pandemic><influenzavirus><intestinal biome><intestinal microbiome><memory T lymphocyte><metabolic phenotype><metabolic profile><metabotype><mitochondrial><mortality><mouse model><murine model><nCoV2><new approaches><novel><novel approaches><novel strategies><novel strategy><ob/ob mouse><obese individuals><obese patients><obese people><obese person><obese population><obese subjects><obesity intervention><obesity surgery><obesity therapy><obesity treatment><observational research study><observational survey><oxidation><oxidative metabolism><pandemic flu><pandemic influenza><pandemic strain of influenza><pathophysiology><patients with obesity><regulatory T-cells><response><retrospective research study><retrospective survey><seasonal flu><seasonal influenza><social role><stomach stapling><systemic inflammation><systemic inflammatory response><thymus derived lymphocyte><viral infection><virus infection><virus-induced disease><vulnerable group><vulnerable individual><vulnerable people><weight loss surgery><weights><white adipose tissue><wt-loss><yellow adipose tissue>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kirk Edward Hevener

UNIVERSITY OF TENNESSEE HEALTH SCI CTR, MEMPHIS, TN

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$735,299
FY 2026

Project Title

Development of Microbiome-Sparing Antibacterials for Clostridioides difficile Infection

Grant Number:

5R01AI182231-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/4/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Hypervirulent, drug-resistant strains of Clostridioides difficile now greatly contribute to the overall morbidity and mortality of C. difficile infection (CDI), resulting in relapse rates of up to 35%, nearly 30,000 deaths per year, and a national burden over $4.5 billion a...

Research Terms

<Acyl Carrier Protein><Address><Adopted><After Care><After-Treatment><Aftercare><Animal Model><Animal Models and Related Studies><Anti-Bacterial Agents><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Assay><Bacteroides><Bacteroidetes><Binding Sites><Bioassay><Biochemical><Biologic Models><Biological><Biological Assay><Biological Models><Biophysics><C diff><C difficile><C. diff><C. difficile><Cell Body><Cells><Cessation of life><Chemicals><Clinical Trials><Clostridioides difficile><Clostridium difficile><Combining Site><Crystallographies><Crystallography><Death><Dehydrogenases><Development><Diarrhea><Drug resistance><Drugs><Ensure><Environment><Enzymatic Biochemistry><Enzyme Antagonist><Enzyme Gene><Enzyme Inhibition><Enzyme Inhibitor><Enzyme Inhibitor Agent><Enzyme Inhibitor Drugs><Enzyme Interaction><Enzymes><Enzymology><Epidemic><Evaluation><Exhibits><Fatty Acids><Firmicutes><Flagyl><Friends><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Generations><Goals><Growth><High Throughput Assay><Hospitals><Imidazole><In Vitro><Infection><Intestinal><Intestines><Isoenzymes><Isonicotinic Acid Hydrazide><Isozymes><Knowledge><Lead><Libraries><Medication><Medicinal Chemistry><Membrane><Metronidazole><Mice><Mice Mammals><Microbiology><Miscellaneous Antibiotic><Model System><Morbidity><Murine><Mus><Oral><Oxidoreductase><Oxidoreductase Gene><Pathway interactions><Patients><Pb element><Pharmaceutic Chemistry><Pharmaceutical Chemistry><Pharmaceutical Preparations><Pharmacology><Physiologic><Physiological><Position><Positioning Attribute><Property><Protein Biochemistry><Protein/Amino Acid Biochemistry><Proteins><Public Health><Reactive Site><Recurrence><Recurrent><Reductases><Relapse><Reporting><Reproduction spores><Research><Resistance><Resistant Clostridium difficile><Risk><Satric><Series><Spores><Structure><Synthesis Chemistry><Synthetic Chemistry><Testing><Thiazoles><Tissue Growth><Validation><Vancomycin><absorption><anti-bacterial><anti-microbial><anti-microbial agent><anti-microbial drug><antimicrobial><biologic><biophysical foundation><biophysical principles><biophysical sciences><bowel><clinical candidate><cost><developmental><digestive tract microbiome><drug candidate><drug discovery><drug resistant><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><essential phospholipids><fat metabolism><fatty acid biosynthesis><fecal microbial community><fecal microbiota><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heavy metal Pb><heavy metal lead><high throughput screening><improved><in vivo><inhibitor><insight><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><isoniazid><lead optimization><lead series><lipid metabolism><membrane structure><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiota><microflora><model of animal><mortality><mouse model><multispecies consortia><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><normal flora><normal microbial flora><normal microbiota><normal microflora><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><pathogen><pathway><pharmacokinetic model><pharmacologic><post treatment><preservation><programs><protective effect><rational design><recurrence prevention><remediation><resistance in Clostridioides difficile><resistance to Drug><resistant><resistant Clostridioides difficile><resistant strains of Clostridioides difficile><resistant to Drug><scaffold><scaffolding><skills><small molecule><standard of care><structural biology><tool><validations>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ryan Walker

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$729,507
FY 2026

Project Title

The effects of a high fructose diet on the gut microbiome and metabolic health: A controlled clinical intervention study

Grant Number:

5R01DK137968-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2024

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Americans commonly consume excess amounts of dietary fructose. Added fructose has been shown to have an adverse impact on metabolic health, including increased insulin resistance and type 2 diabetes (T2D) risk. However, the mechanisms that link dietary fructose and metabolic health a...

Research Terms

<0-11 years old><21+ years old><Address><Adult><Adult Human><Adult-Onset Diabetes Mellitus><American><Animals><Bacteria><Calories><Carbohydrates><Carbon><Causality><Characteristics><Child><Child Youth><Children (0-21)><Clinical><Clinical Treatment><Clinical Trials><Colon><Complex><Computing Methodologies><Consumption><Cross-Over Trials><Crossover Trials><D-Glucose><Data><Dextrose><Diet><Dietary Intervention><Dimensions><Disease><Disorder><Endotoxemia><Etiology><Fats><Fatty Liver><Fatty acid glycerol esters><Feces><Fructose><Future><GI microbiome><GI microbiota><Gases><Gastrointestinal microbiota><Germ-Free><Glucose><Goals><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><Health><Human><Inflammation><Inflammatory><Inflammatory Response><Insulin Resistance><Intermediary Metabolism><Intervention Studies><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Isocaloric><Isotopes><Ketosis-Resistant Diabetes Mellitus><Knowledge><Label><Large Intestine><Levulose><Link><Liver><Liver Steatosis><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malabsorption Syndromes><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Maturity-Onset Diabetes Mellitus><Measures><Mediating><Mediator><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolism><Mice><Mice Mammals><Microbe><Microbiomics><Modeling><Modern Man><Murine><Mus><NIDDM><NMR Imaging><NMR Tomography><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nuclear Magnetic Resonance Imaging><Nutrition Interventions><Nutritional Interventions><Obesity><Outcome><Participant><Population><Prevalence><Prevention><Process><Production><Randomized><Research><Research Design><Risk><Rodent Model><Role><Sampling><Serum Markers><Slow-Onset Diabetes Mellitus><Small Intestines><Stable Diabetes Mellitus><Statistical Methods><Structure><Study Type><T2 DM><T2D><T2DM><Testing><Thesaurismosis><Transplantation><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Vulnerable Populations><Zeugmatography><adiposity><adult onset diabetes><adulthood><alter microbiome><arm><blood glucose regulation><calorie><causation><clinical intervention><clinical therapy><computational methodology><computational methods><computer based method><computer methods><computing method><corpulence><cross-sectional investigation><cross-sectional research><cytokine><design><designing><diabetes risk><diet intervention><dietary><dietary excess><diets><digestive tract microbiome><disease causation><disease risk><disorder risk><elastic imaging><elasticity imaging><elastography><enteric microbial community><enteric microbiome><enteric microbiota><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal sample><fecal transplant><fecal transplantation><gastrointestinal absorption disorder><gastrointestinal microbial flora><gastrointestinal microbiome><glucose control><glucose homeostasis><glucose regulation><gut community><gut flora><gut health><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hepatic body system><hepatic organ system><hepatic steatosis><hepatosteatosis><human disease><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiota><improved><inflammation marker><inflammatory marker><insulin resistant><insulin tolerance><intervention research><interventional research><interventional study><interventions research><intestinal biome><intestinal flora><intestinal malabsorption><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><investigate cross-sectional><ketosis resistant diabetes><kids><large bowel><malabsorption><maturity onset diabetes><metabolism disorder><metabolism measurement><metabolomics><metabonomics><metagenome sequencing><metagenomic sequencing><microbial><microbial consortia><microbial flora><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><microbiome research><microbiome science><microbiome studies><microbiota><microbiota community><microflora><mouse model><multispecies consortia><murine model><novel><oxidation><randomisation><randomization><randomly assigned><small bowel><social role><statistic methods><stool><stool sample><stool specimen><study cross-sectional><study design><sugar><survey cross-sectional><sweetened beverage><transplant><trial regimen><trial treatment><type 2 DM><type II DM><type two diabetes><vulnerable group><vulnerable individual><vulnerable people><youngster>
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Vanni Bucci

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$702,553
FY 2026

Project Title

Aging Microbiome, Immunosenescence, and risk of Multi-drug Resistant Organism Colonization and Infection in the Nursing Home

Grant Number:

5R01AG075283-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Multidrug resistant organisms (MDROs) are bacteria that have become resistant to more than one antimicrobial agent. Intestinal MDROs constitute a major threat to public health because they are increasingly difficult to treat and result in increased costs, morbidity, and mortality when they ...

Research Terms

<Acceleration><Active Follow-up><Address><Affect><Age><Aging><Algorithms><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Autoregulation><Bacteria><Bacterial Infections><Blood Sample><Blood specimen><C diff><C difficile><C. diff><C. difficile><Cellular Immune Function><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Characteristics><Chronic><Clinical><Clostridioides difficile><Clostridium difficile><Colon><Colonic inflammation><Communicable Diseases><Communities><Data><Data Collection><Deterioration><Development><Diagnostic Method><Diagnostic Procedure><Diagnostic Technique><Disease><Disorder><Drugs><Dysfunction><Elderly><Enrollment><Epithelium><Exhibits><Frail Elderly><Frail Elders><Frail Older Adults><Frail Seniors><Functional disorder><Future><GI colonization><GI microbiome><Genomics><Genotype><Goals><Health><Health Policy><High Prevalence><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Home environment><Homeostasis><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune system><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><In Vitro><Individual><Infection><Infectious Agent><Infectious Diseases><Infectious Disorder><Inflammaging><Inflammation><Inflammatory><Intervention><Intestinal><Intestines><Knowledge><Label><MDR organism><MDR pathogen><Medication><Methods><Miscellaneous Antibiotic><Modeling><Molecular><Morbidity><Multi-Drug Resistance><Multidrug Resistance><Multiple Drug Resistance><Multiple Drug Resistant><Nursing Homes><Organism><Organism Strains><Pathogenicity><Performance><Peripheral><Pharmaceutical Preparations><Physiological Homeostasis><Physiopathology><Population><Predicting Risk><Predisposition><Prevalence><Prevention><Public Health><Residencies><Resistance><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistant to Multiple Drug><Resistant to multi-drug><Resistant to multidrug><Resolution><Risk><Risk Factors><Sampling><Shapes><Site><Susceptibility><System><T-Cells><T-Lymphocyte><Technology><Testing><Time><Transmission><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Vulnerable Populations><active followup><advanced age><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><age-related inflammation><ages><aging associated inflammation><alter microbiome><analyze microbiome><anti-microbial agent><anti-microbial drug><bacteria infection><bacterial disease><bowel><bowel inflammation><cohort><combat><cost><cost effective><developmental><digestive tract microbiome><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><enroll><enteric microbiome><epidemiology research study><epidemiology study><epidemiology survey><fecal sample><follow up><follow-up><followed up><followup><forecasting risk><frail older adult><frailty><gastrointestinal microbiome><gastrointestinal tract colonization><geriatric><gut colonization><gut dysbiosis><gut inflammation><gut microbiome><gut-associated microbiome><health care policy><healthy aging><healthy human aging><host microbiome><immune function><immune senescence><immunosenescence><improved><in vivo><indexing><infectious organism><inflamed bowel><inflamed colon><inflamed gut><inflamed intestine><inflamm-ageing><inflamm-aging><inflammation associated with aging><intestinal biome><intestinal colonization><intestinal epithelium><intestinal inflammation><intestinal microbiome><large scale data><large scale data sets><large scale datasets><living system><microbe pathogen><microbial><microbial imbalance><microbial pathogen><microbiome><microbiome adaptation><microbiome alteration><microbiome analysis><microbiome community composition><microbiome composition><microbiome intervention><microbiome perturbation><microbiome signature><microbiome species composition><microbiome structure><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><mortality><multi-drug resistant><multi-drug resistant organism><multi-drug resistant pathogen><multidrug resistant><multidrug resistant organism><multidrug resistant pathogen><multiple drug resistant organism><multiple drug resistant pathogen><new approaches><novel><novel approaches><novel strategies><novel strategy><nursing home><older adult><older adulthood><pathogen><pathogenic microbe><pathophysiology><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predictive tools><predicts risk><prevent><preventing><prospective><residence><residential building><residential site><resistant><resolutions><risk prediction><risk predictions><senior citizen><stool sample><stool specimen><systemic inflammation><systemic inflammatory response><thymus derived lymphocyte><transmission process><vulnerable group><vulnerable individual><vulnerable people>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

John Patrick Haran

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$702,553
FY 2026

Project Title

Aging Microbiome, Immunosenescence, and risk of Multi-drug Resistant Organism Colonization and Infection in the Nursing Home

Grant Number:

5R01AG075283-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Multidrug resistant organisms (MDROs) are bacteria that have become resistant to more than one antimicrobial agent. Intestinal MDROs constitute a major threat to public health because they are increasingly difficult to treat and result in increased costs, morbidity, and mortality when they ...

Research Terms

<Acceleration><Active Follow-up><Address><Affect><Age><Aging><Algorithms><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Autoregulation><Bacteria><Bacterial Infections><Blood Sample><Blood specimen><C diff><C difficile><C. diff><C. difficile><Cellular Immune Function><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Characteristics><Chronic><Clinical><Clostridioides difficile><Clostridium difficile><Colon><Colonic inflammation><Communicable Diseases><Communities><Data><Data Collection><Deterioration><Development><Diagnostic Method><Diagnostic Procedure><Diagnostic Technique><Disease><Disorder><Drugs><Dysfunction><Elderly><Enrollment><Epithelium><Exhibits><Frail Elderly><Frail Elders><Frail Older Adults><Frail Seniors><Functional disorder><Future><GI colonization><GI microbiome><Genomics><Genotype><Goals><Health><Health Policy><High Prevalence><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Home environment><Homeostasis><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune system><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><In Vitro><Individual><Infection><Infectious Agent><Infectious Diseases><Infectious Disorder><Inflammaging><Inflammation><Inflammatory><Intervention><Intestinal><Intestines><Knowledge><Label><MDR organism><MDR pathogen><Medication><Methods><Miscellaneous Antibiotic><Modeling><Molecular><Morbidity><Multi-Drug Resistance><Multidrug Resistance><Multiple Drug Resistance><Multiple Drug Resistant><Nursing Homes><Organism><Organism Strains><Pathogenicity><Performance><Peripheral><Pharmaceutical Preparations><Physiological Homeostasis><Physiopathology><Population><Predicting Risk><Predisposition><Prevalence><Prevention><Public Health><Residencies><Resistance><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistant to Multiple Drug><Resistant to multi-drug><Resistant to multidrug><Resolution><Risk><Risk Factors><Sampling><Shapes><Site><Susceptibility><System><T-Cells><T-Lymphocyte><Technology><Testing><Time><Transmission><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Vulnerable Populations><active followup><advanced age><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><age-related inflammation><ages><aging associated inflammation><alter microbiome><analyze microbiome><anti-microbial agent><anti-microbial drug><bacteria infection><bacterial disease><bowel><bowel inflammation><cohort><combat><cost><cost effective><developmental><digestive tract microbiome><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><enroll><enteric microbiome><epidemiology research study><epidemiology study><epidemiology survey><fecal sample><follow up><follow-up><followed up><followup><forecasting risk><frail older adult><frailty><gastrointestinal microbiome><gastrointestinal tract colonization><geriatric><gut colonization><gut dysbiosis><gut inflammation><gut microbiome><gut-associated microbiome><health care policy><healthy aging><healthy human aging><host microbiome><immune function><immune senescence><immunosenescence><improved><in vivo><indexing><infectious organism><inflamed bowel><inflamed colon><inflamed gut><inflamed intestine><inflamm-ageing><inflamm-aging><inflammation associated with aging><intestinal biome><intestinal colonization><intestinal epithelium><intestinal inflammation><intestinal microbiome><large scale data><large scale data sets><large scale datasets><living system><microbe pathogen><microbial><microbial imbalance><microbial pathogen><microbiome><microbiome adaptation><microbiome alteration><microbiome analysis><microbiome community composition><microbiome composition><microbiome intervention><microbiome perturbation><microbiome signature><microbiome species composition><microbiome structure><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><mortality><multi-drug resistant><multi-drug resistant organism><multi-drug resistant pathogen><multidrug resistant><multidrug resistant organism><multidrug resistant pathogen><multiple drug resistant organism><multiple drug resistant pathogen><new approaches><novel><novel approaches><novel strategies><novel strategy><nursing home><older adult><older adulthood><pathogen><pathogenic microbe><pathophysiology><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predictive tools><predicts risk><prevent><preventing><prospective><residence><residential building><residential site><resistant><resolutions><risk prediction><risk predictions><senior citizen><stool sample><stool specimen><systemic inflammation><systemic inflammatory response><thymus derived lymphocyte><transmission process><vulnerable group><vulnerable individual><vulnerable people>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sukirth Murthy Ganesan

UNIVERSITY OF IOWA, IOWA CITY, IA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$699,184
FY 2026

Project Title

Determining the Impact of Metabolic Syndrome on the Oral Microbiome and Periodontal Health Using a Longitudinal Systems Biology Approach

Grant Number:

1R01DE034679-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Metabolic Syndrome (MetS) affects over one-third of U.S. adults and is closely linked with oral health issues, particularly periodontitis. The bidirectional relationship between MetS and periodontitis exacerbates both conditions, but the underlying mechanisms remain unclear. Our prel...

Research Terms

<21+ years old><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><BMI><BMI percentile><BMI z-score><Bacteroides gingivalis><Biochemical><Biological Markers><Blood Pressure><Body mass index><Buccal Cavity><Buccal Cavity Head and Neck><Cardiovascular Diseases><Cavitas Oris><Chronic><Chronic Periodontitis><Clinical><Clinical Research><Clinical Study><Data><Development><Disease><Disorder><Dissociation><Dose><Drug Therapy><Ecologic Systems><Ecological Systems><Ecosystem><Environment><Epidemic><Equation><Foundations><Funding><Future><Gas Chromatography><Gingival Crevicular Fluid><Gingival Exudate><Goals><Gum Disease><Health><High Prevalence><Immune system><Inflammation><Inflammation Mediators><Inflammatory><Insulin Resistance><Interdisciplinary Research><Interdisciplinary Study><Intervention><Investigation><Ketosis-Resistant Diabetes Mellitus><Knowledge><LC/MS><Life Style Modification><Link><Lipids><Longitudinal Studies><Longitudinal Surveys><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Maturity-Onset Diabetes Mellitus><Mediating><Mediation><Medical><Metabolic><Metabolic syndrome><Modeling><Molecular><Monitor><Mouth><Mouth microbiome><Multidisciplinary Collaboration><Multidisciplinary Research><NIDDM><Natural History><Nature><Negotiating><Negotiation><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Obesity><Operative Procedures><Operative Surgical Procedures><Oral><Oral cavity><Oral health><P gingivalis><P. gingivalis><Parodontosis><Pathogenicity><Pathway interactions><Patients><Periodontal Diseases><Periodontitis><Pharmacological Treatment><Pharmacotherapy><Physiologic><Physiological><Porphyromonas gingivalis><Prognostic Marker><Public Health><Quetelet index><Resolution><Risk><Sampling><Selenomonas><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Surgical><Surgical Interventions><Surgical Procedure><System><Systems Biology><T2 DM><T2D><T2DM><Techniques><Testing><Therapeutic><Time><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Variant><Variation><Virulent><Weight><adipocytokines><adipokines><adiposity><adult onset diabetes><adulthood><alter microbiome><bio-markers><biologic marker><biomarker><cardiovascular disorder><clinical effect><cohort><corpulence><cytokine><decision tree learning><dental health><design><designing><developmental><drug intervention><drug treatment><dysbacteriosis><dysbiosis><dysbiotic><healthy weight><high risk><host microbiota><host microflora><improved><inflammatory mediator><insight><insulin resistant><insulin tolerance><intervention effect><ketosis resistant diabetes><learning algorithm><life style intervention><lifestyle intervention><lifestyle modification><liquid chromatography mass spectrometry><long-term study><longitudinal outcome studies><longitudinal research study><maturity onset diabetes><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbial><microbial imbalance><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><molecular biomarker><molecular marker><obese patients><oral microbiome><pathway><patients with obesity><periodontal disorder><periodontium disease><periodontium disorder><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><post intervention><prognostic><prognostic biomarker><prognostic indicator><programs><resident microbes><resident microflora><resolutions><response><small molecule><subgingival microbiome><surgery><type 2 DM><type II DM><type two diabetes><vapor phase chromatography><weights>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Toni Darville

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$679,850
FY 2026

Project Title

Natural History of Chlamydia trachomatis genital tract infection in women

Grant Number:

5R01AI170959-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/2/2024

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Chlamydia trachomatis is a well-recognized PID pathogen for which no vaccine is available. Women are at risk for reproductive sequelae when infection ascends into the upper reproductive tract, driving inflammatory processes that trigger immune pathology. However, the bacterial and/or host factors th...

Research Terms

<Acceleration><Automobile Driving><Bacteria><Binding><Biological Markers><Biometrics><Biometry><Biopsy><Biostatistics><C trachomatis><C. trachomatis><Cannot achieve a pregnancy><Cell Body><Cell Culture Techniques><Cells><Cervical><Cervix><Cervix Uteri><Chlamydia><Chlamydia Infections><Chlamydia trachomatis><Chlamydial Infection><Clinical><Clinical Evaluation><Clinical Testing><Complex><Data><Data Set><Development><Diagnosis><Difficulty conceiving><Disease><Disorder><Ectopic Pregnancy><Endocervix><Endometrial><Endometritis><Endometrium><Environment><Environmental Factor><Environmental Risk Factor><Epithelial Cell Proliferation><Epithelial Cells><Evaluation><Expression Signature><Fallopian Tubes><Focal Infection><Funding><Gene Expression><Gene Expression Profile><Gene Transcription><Generalized Growth><Genetic Transcription><Goals><Growth><Health><High Risk Woman><Host Factor><Host Factor Protein><Human><Immune><Immune response><Immunes><Immunity><Indoles><Infection><Infection Control><Infertility><Inflammation><Inflammatory><Inflammatory Response><Innate Immunity><Integration Host Factors><Investigation><Knowledge><Lactobacillus><Lead><Life><Link><Mammalian Oviducts><Mediating><Mission><Miyagawanella><Modeling><Modern Man><Molecular Interaction><Multiomic Data><NIH><National Institutes of Health><Native Immunity><Natural History><Natural Immunity><Non-Invasive Detection><Non-Specific Immunity><Noninvasive Detection><Nonspecific Immunity><Oral Contraceptives><Outcome><Pathogenesis><Pathology><Pathway interactions><Pattern><Pb element><Pelvic Inflammatory Disease><Persons><Pilot Projects><Population><Predisposition><Primary Infection><Process><Public Health><RNA Expression><Research><Research Specimen><Rickettsia trachomae><Risk><Salpinx><Severities><Sexual Partners><Sexual Transmission><Sexually Transmitted Diseases><Sexually Transmitted Disorder><Sexually Transmitted Infection><Site><Specimen><Susceptibility><Systems Biology><Technology><Testing><Therapeutic><Tissue Growth><Transcription><Translating><United States National Institutes of Health><Uterine Cervix><Uterine Tubes><Uterine lining><Vaccine Design><Vaccines><Vagina><Venereal Diseases><Venereal Disorders><Venereal Infections><Woman><at-risk females><at-risk women><bedsonia><bio-markers><biologic marker><biomarker><biomarker development><biomarker identification><birth control pill><candidate biomarker><candidate marker><cell culture><cell cultures><cervicovaginal><cervicovaginal microbiome><chlamydia vaccine><chlamydial disease><chronic pelvic floor pain><chronic pelvic pain><chronic pelvic pain syndrome><clinical relevance><clinical test><clinically relevant><co-infection><cohort><coinfection><community microbes><data integration><develop a vaccine><develop vaccines><development of a vaccine><developmental><diagnostic biomarker><diagnostic development><diagnostic marker><disability><driving><dysbacteriosis><dysbiosis><dysbiotic><environmental change><environmental risk><environmental stresses><environmental stressor><evaluate vaccines><extrauterine pregnancy><female genital tract infection><female infections><female reproductive tract infection><females at high risk><fertility cessation><fertility loss><fitness><gene expression pattern><gene expression signature><genital infection><genital tract><genital tract infection in women><heavy metal Pb><heavy metal lead><high risk females><host response><identification of biomarkers><identification of new biomarkers><immune system response><immunoresponse><improved><in vivo><infected females><infected women><infection in the female genital tract><infection in the female reproductive tract><infection localized><infections among women><infections in females><infections in women><infertile><innovate><innovation><innovative><insight><knowledge base><local infection><marker identification><member><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metatranscriptomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><microorganism community><molecular biomarker><molecular marker><multiple omic data><multispecies consortia><new diagnostics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation diagnostics><next generation therapeutics><novel><novel diagnostics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><oviduct><pathogen><pathway><pelvic inflammation disease><pelvic inflammation disorder><pelvic inflammatory disorder><pelvic inflammatory syndrome><pelvic myofascial pain><pilot study><polymicrobial community><predict responsiveness><predicting response><pressure><prevent><preventing><reproductive><reproductive morbidity><reproductive outcome><reproductive tract><reproductive tract infection in women><research clinical testing><response><screening><screenings><sex partner><sexually acquired infection><sexually transmitted><transcriptional profile><transcriptional signature><transcriptomics><vaccine development><vaccine evaluation><vaccine screening><vaccine testing><women at high risk><women experiencing infections><women infections><women with infections>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

CATHERINE MARY O'CONNELL

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$679,850
FY 2026

Project Title

Natural History of Chlamydia trachomatis genital tract infection in women

Grant Number:

5R01AI170959-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/2/2024

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Chlamydia trachomatis is a well-recognized PID pathogen for which no vaccine is available. Women are at risk for reproductive sequelae when infection ascends into the upper reproductive tract, driving inflammatory processes that trigger immune pathology. However, the bacterial and/or host factors th...

Research Terms

<Acceleration><Automobile Driving><Bacteria><Binding><Biological Markers><Biometrics><Biometry><Biopsy><Biostatistics><C trachomatis><C. trachomatis><Cannot achieve a pregnancy><Cell Body><Cell Culture Techniques><Cells><Cervical><Cervix><Cervix Uteri><Chlamydia><Chlamydia Infections><Chlamydia trachomatis><Chlamydial Infection><Clinical><Clinical Evaluation><Clinical Testing><Complex><Data><Data Set><Development><Diagnosis><Difficulty conceiving><Disease><Disorder><Ectopic Pregnancy><Endocervix><Endometrial><Endometritis><Endometrium><Environment><Environmental Factor><Environmental Risk Factor><Epithelial Cell Proliferation><Epithelial Cells><Evaluation><Expression Signature><Fallopian Tubes><Focal Infection><Funding><Gene Expression><Gene Expression Profile><Gene Transcription><Generalized Growth><Genetic Transcription><Goals><Growth><Health><High Risk Woman><Host Factor><Host Factor Protein><Human><Immune><Immune response><Immunes><Immunity><Indoles><Infection><Infection Control><Infertility><Inflammation><Inflammatory><Inflammatory Response><Innate Immunity><Integration Host Factors><Investigation><Knowledge><Lactobacillus><Lead><Life><Link><Mammalian Oviducts><Mediating><Mission><Miyagawanella><Modeling><Modern Man><Molecular Interaction><Multiomic Data><NIH><National Institutes of Health><Native Immunity><Natural History><Natural Immunity><Non-Invasive Detection><Non-Specific Immunity><Noninvasive Detection><Nonspecific Immunity><Oral Contraceptives><Outcome><Pathogenesis><Pathology><Pathway interactions><Pattern><Pb element><Pelvic Inflammatory Disease><Persons><Pilot Projects><Population><Predisposition><Primary Infection><Process><Public Health><RNA Expression><Research><Research Specimen><Rickettsia trachomae><Risk><Salpinx><Severities><Sexual Partners><Sexual Transmission><Sexually Transmitted Diseases><Sexually Transmitted Disorder><Sexually Transmitted Infection><Site><Specimen><Susceptibility><Systems Biology><Technology><Testing><Therapeutic><Tissue Growth><Transcription><Translating><United States National Institutes of Health><Uterine Cervix><Uterine Tubes><Uterine lining><Vaccine Design><Vaccines><Vagina><Venereal Diseases><Venereal Disorders><Venereal Infections><Woman><at-risk females><at-risk women><bedsonia><bio-markers><biologic marker><biomarker><biomarker development><biomarker identification><birth control pill><candidate biomarker><candidate marker><cell culture><cell cultures><cervicovaginal><cervicovaginal microbiome><chlamydia vaccine><chlamydial disease><chronic pelvic floor pain><chronic pelvic pain><chronic pelvic pain syndrome><clinical relevance><clinical test><clinically relevant><co-infection><cohort><coinfection><community microbes><data integration><develop a vaccine><develop vaccines><development of a vaccine><developmental><diagnostic biomarker><diagnostic development><diagnostic marker><disability><driving><dysbacteriosis><dysbiosis><dysbiotic><environmental change><environmental risk><environmental stresses><environmental stressor><evaluate vaccines><extrauterine pregnancy><female genital tract infection><female infections><female reproductive tract infection><females at high risk><fertility cessation><fertility loss><fitness><gene expression pattern><gene expression signature><genital infection><genital tract><genital tract infection in women><heavy metal Pb><heavy metal lead><high risk females><host response><identification of biomarkers><identification of new biomarkers><immune system response><immunoresponse><improved><in vivo><infected females><infected women><infection in the female genital tract><infection in the female reproductive tract><infection localized><infections among women><infections in females><infections in women><infertile><innovate><innovation><innovative><insight><knowledge base><local infection><marker identification><member><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metatranscriptomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><microorganism community><molecular biomarker><molecular marker><multiple omic data><multispecies consortia><new diagnostics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation diagnostics><next generation therapeutics><novel><novel diagnostics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><oviduct><pathogen><pathway><pelvic inflammation disease><pelvic inflammation disorder><pelvic inflammatory disorder><pelvic inflammatory syndrome><pelvic myofascial pain><pilot study><polymicrobial community><predict responsiveness><predicting response><pressure><prevent><preventing><reproductive><reproductive morbidity><reproductive outcome><reproductive tract><reproductive tract infection in women><research clinical testing><response><screening><screenings><sex partner><sexually acquired infection><sexually transmitted><transcriptional profile><transcriptional signature><transcriptomics><vaccine development><vaccine evaluation><vaccine screening><vaccine testing><women at high risk><women experiencing infections><women infections><women with infections>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Priti Balchandani

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$676,608
FY 2026

Project Title

Investigating the role of the gut-brain axis in Alzheimer's Disease mitigation: 7T MRI, iNOS inhibition and inulin diet

Grant Number:

1R01AG089493-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Alzheimer’s disease (AD) is the most common form of dementia with hallmarks of extracellular beta amyloid (A) plaques (A), intraneuronal tau tangles (T), and neurodegeneration (N), known as the A/T/N framework, a descriptive classification for AD biomarkers. Accumulating evidence s...

Research Terms

<3xTg><3xTg-AD mice><3xTg-AD mouse><AD biological marker><AD biomarker><AD dementia><AD patients><AD related biomarker><AD risk><AD risk factor><Acceleration><Address><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease patient><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's patient><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Ammon Horn><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Experiments><Animal Model><Animal Models and Related Studies><Animals><Area><Assay><Award><Aβ><Bacteria><Bioassay><Biochemical><Biological Assay><Blood Vessels><Brain><Brain Nervous System><Cerebrovascular Circulation><Classification><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Dementia><Diet><Dietary Intervention><Disease><Disorder><Disturbance in cognition><E coli><E. coli><Encephalon><Equilibrium><Escherichia coli><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Expression><Goals><Hippocampus><Human><INOS><Impaired cognition><Individual><Inducible Nitric Oxide Synthase><Inflammatory><Intervention><Intervention Studies><Inulin><Knock-out><Knockout><Knowledge><Lactobacillus><Link><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Macrophage Nitric Oxide Synthase><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mice><Mice Mammals><Microbe><Modeling><Modern Man><Murine><Mus><NIH><NMR Imaging><NMR Tomography><NOS2><NOS2A><NOS2A gene><NOS2A, Inducible, Hepatocyte><National Institutes of Health><Nerve Degeneration><Neuritic Plaques><Neurofibrillary Tangles><Neuron Degeneration><Nitric Oxide Synthase 2A><Nuclear Magnetic Resonance Imaging><Nutrition Interventions><Nutritional Interventions><PET><PET Scan><PET imaging><PETSCAN><PETT><Participant><Pathologic><Pathology><Pathway interactions><Physiology><Pilot Projects><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Pre-Clinical Model><Preclinical Models><Primary Senile Degenerative Dementia><Production><Protocol><Protocols documentation><Rad.-PET><Research Design><Role><Senile Plaques><Severities><Short-Chain Fatty Acids><Staining method><Stains><Study Type><Supplementation><Systematics><Testing><Time><Transgenic Organisms><Transplantation><United States National Institutes of Health><Volatile Fatty Acids><Zeugmatography><a beta peptide><abeta><alzheimer risk><amyloid beta><amyloid beta plaque><amyloid-b plaque><amyloid-b protein><animal experiment><aβ plaques><balance><balance function><beta amyloid fibril><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><blood flow in brain><brain blood circulation><brain blood flow><brain volume><cerebral blood flow><cerebral circulation><cerebrocirculation><cerebrovascular blood flow><cognitive assessment><cognitive dysfunction><cognitive function><cognitive loss><cognitive testing><community microbes><cored plaque><design><designing><diet control><diet intervention><dietary control><diets><diffuse plaque><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><effective intervention><enteric microbial community><enteric microbiome><enteric microbiota><experimental animal><experimental animals><extracellular><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal sample><fecal transplant><fecal transplantation><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><hippocampal><human model><imaging biomarker><imaging marker><imaging-based biological marker><imaging-based biomarker><imaging-based marker><individual heterogeneity><individual variability><individual variation><innovate><innovation><innovative><intervention research><interventional research><interventional study><interventions research><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><microbe community><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome sequencing><microbiota><microflora><microorganism community><microtubule bound tau><microtubule-bound tau><model of animal><model of human><mouse model><multi-modality><multimodality><multispecies consortia><murine model><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuroimaging biomarker><neuroimaging marker><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal degeneration><neuropathologic><neuropathological><neuropathology><neuroprotection><neuroprotective><novel><pathogenic E coli><pathogenic E. coli><pathogenic Escherichia coli><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><pilot study><polymicrobial community><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><prebiotics><preclinical><primary degenerative dementia><recruit><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social role><soluble amyloid precursor protein><stool sample><stool specimen><study design><substantia alba><super high resolution><superresolution><tangle><tau><tau Proteins><tau factor><transcriptomics><transgenic><translational study><transplant><ultra high resolution><vascular><white matter><τ Proteins>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ai-Ling Lin

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$676,608
FY 2026

Project Title

Investigating the role of the gut-brain axis in Alzheimer's Disease mitigation: 7T MRI, iNOS inhibition and inulin diet

Grant Number:

1R01AG089493-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Alzheimer’s disease (AD) is the most common form of dementia with hallmarks of extracellular beta amyloid (A) plaques (A), intraneuronal tau tangles (T), and neurodegeneration (N), known as the A/T/N framework, a descriptive classification for AD biomarkers. Accumulating evidence s...

Research Terms

<3xTg><3xTg-AD mice><3xTg-AD mouse><AD biological marker><AD biomarker><AD dementia><AD patients><AD related biomarker><AD risk><AD risk factor><Acceleration><Address><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease patient><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's patient><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Ammon Horn><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Experiments><Animal Model><Animal Models and Related Studies><Animals><Area><Assay><Award><Aβ><Bacteria><Bioassay><Biochemical><Biological Assay><Blood Vessels><Brain><Brain Nervous System><Cerebrovascular Circulation><Classification><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Dementia><Diet><Dietary Intervention><Disease><Disorder><Disturbance in cognition><E coli><E. coli><Encephalon><Equilibrium><Escherichia coli><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Expression><Goals><Hippocampus><Human><INOS><Impaired cognition><Individual><Inducible Nitric Oxide Synthase><Inflammatory><Intervention><Intervention Studies><Inulin><Knock-out><Knockout><Knowledge><Lactobacillus><Link><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Macrophage Nitric Oxide Synthase><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mice><Mice Mammals><Microbe><Modeling><Modern Man><Murine><Mus><NIH><NMR Imaging><NMR Tomography><NOS2><NOS2A><NOS2A gene><NOS2A, Inducible, Hepatocyte><National Institutes of Health><Nerve Degeneration><Neuritic Plaques><Neurofibrillary Tangles><Neuron Degeneration><Nitric Oxide Synthase 2A><Nuclear Magnetic Resonance Imaging><Nutrition Interventions><Nutritional Interventions><PET><PET Scan><PET imaging><PETSCAN><PETT><Participant><Pathologic><Pathology><Pathway interactions><Physiology><Pilot Projects><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Pre-Clinical Model><Preclinical Models><Primary Senile Degenerative Dementia><Production><Protocol><Protocols documentation><Rad.-PET><Research Design><Role><Senile Plaques><Severities><Short-Chain Fatty Acids><Staining method><Stains><Study Type><Supplementation><Systematics><Testing><Time><Transgenic Organisms><Transplantation><United States National Institutes of Health><Volatile Fatty Acids><Zeugmatography><a beta peptide><abeta><alzheimer risk><amyloid beta><amyloid beta plaque><amyloid-b plaque><amyloid-b protein><animal experiment><aβ plaques><balance><balance function><beta amyloid fibril><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><blood flow in brain><brain blood circulation><brain blood flow><brain volume><cerebral blood flow><cerebral circulation><cerebrocirculation><cerebrovascular blood flow><cognitive assessment><cognitive dysfunction><cognitive function><cognitive loss><cognitive testing><community microbes><cored plaque><design><designing><diet control><diet intervention><dietary control><diets><diffuse plaque><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><effective intervention><enteric microbial community><enteric microbiome><enteric microbiota><experimental animal><experimental animals><extracellular><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal sample><fecal transplant><fecal transplantation><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><hippocampal><human model><imaging biomarker><imaging marker><imaging-based biological marker><imaging-based biomarker><imaging-based marker><individual heterogeneity><individual variability><individual variation><innovate><innovation><innovative><intervention research><interventional research><interventional study><interventions research><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><microbe community><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome sequencing><microbiota><microflora><microorganism community><microtubule bound tau><microtubule-bound tau><model of animal><model of human><mouse model><multi-modality><multimodality><multispecies consortia><murine model><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuroimaging biomarker><neuroimaging marker><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal degeneration><neuropathologic><neuropathological><neuropathology><neuroprotection><neuroprotective><novel><pathogenic E coli><pathogenic E. coli><pathogenic Escherichia coli><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><pilot study><polymicrobial community><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><prebiotics><preclinical><primary degenerative dementia><recruit><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social role><soluble amyloid precursor protein><stool sample><stool specimen><study design><substantia alba><super high resolution><superresolution><tangle><tau><tau Proteins><tau factor><transcriptomics><transgenic><translational study><transplant><ultra high resolution><vascular><white matter><τ Proteins>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Tanya Lynn Alderete

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$671,716
FY 2026

Project Title

Pre- and Postnatal Exposure to Air Pollutants and the Gut Microbiome: Implications for Brain Development in Early and Mid-Childhood

Grant Number:

5R01ES035056-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Early life exposure to air pollution (AP), which disproportionately affects underserved communities, is thought to disrupt cognitive, emotional, and behavioral development. Human studies show that exposure during the prenatal and early postnatal periods are associated with developmental del...

Research Terms

<0-11 years old><21+ years old><AD/HD><ADHD><ASD><Active Follow-up><Address><Adult><Adult Human><Affect><Age Months><Air Pollutants><Air Pollution><Amino Acids><Ammon Horn><Animal Model><Animal Models and Related Studies><Anxiety><Archives><Attention deficit hyperactivity disorder><Attenuated><Autism><Autistic Disorder><Bacteroides><Behavioral><Bile Acids><Birth><Blood flow><Brain><Brain Nervous System><Child><Child Youth><Childhood><Children (0-21)><Clostridium><Cognition><Cognitive><Cornu Ammonis><County><DNA seq><DNA sequencing><DNAseq><Data><Development><Developmental Delay><Developmental Delay Disorders><Early Infantile Autism><Emotional><Encephalon><Environmental Exposure><Exposure to><Feces><Functional Metagenomics><Funding><GI microbiome><Generalized Growth><Growth><Health><Hippocampus><Hortega cell><Human><Impairment><Infant><Infantile Autism><Inflammation><Intervention><Investigators><Kanner's Syndrome><Knowledge><Language><Lateral><Latino><Learning Disabilities><Learning disability><Life><Link><Lipid Peroxidation><Lipids><Literature><Longitudinal Studies><Longitudinal Surveys><Los Angeles><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Maternal Health><Maternal Nutrition><Maternal diet><Measures><Mediating><Mediator><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental Depression><Mental disorders><Mental health disorders><Metabolic Pathway><Metagenomics><Microglia><Modern Man><Mothers><Motor><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Neural Development><Neurocognitive><Neurodevelopmental Disorder><Neurological Development Disorder><Nuclear Magnetic Resonance Imaging><Nutritional><Outcome><Oxidative Stress><Parietal Lobe><Parturition><Pathway interactions><Physiology><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Production><Psychiatric Disease><Psychiatric Disorder><Research><Research Personnel><Researchers><Rest><Role><School-Age Population><Short-Chain Fatty Acids><Specific Child Development Disorders><Structure><Temporal Lobe><Testing><Tissue Growth><United States National Institutes of Health><Variant><Variation><Volatile Fatty Acids><Zeugmatography><active followup><adulthood><aminoacid><attenuate><attenuates><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><bacteria in the gut><brain MR imaging><brain MRI><brain magnetic resonance imaging><brain tissue><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><cognitive ability><cognitive assessment><cognitive development><cognitive performance><cognitive testing><cohort><depression><developmental><digestive tract microbiome><early life exposure><economic cost><enteric microbiome><exposed in utero><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal metabolome><fecal sample><feeding><fetal exposure><follow up><follow-up><followed up><followup><frontal cortex><frontal lobe><gastrointestinal microbiome><gitter cell><gut bacteria><gut microbiome><gut microbiome of infant><gut-associated microbiome><hippocampal><in utero exposure><infancy><infant gut microbiome><infantile><intestinal biome><intestinal microbiome><intra-uterine environmental exposure><intrauterine environmental exposure><kids><knowledge base><long-term study><longitudinal outcome studies><longitudinal research study><maternal nutrition during pregnancy><mental illness><mesoglia><metabolic profile><metabolism measurement><metabolomics><metabonomics><microbial><microglial cell><microgliocyte><model of animal><mother nutrition><multi-modality><multidisciplinary><multimodality><myelination><neonate gut microbiome><neurodevelopment><neurodevelopmental disease><neurogenesis><newborn gut microbiome><novel><nutritious><ontogeny><parietal cortex><pathway><pediatric><perivascular glial cell><post-natal period><postnatal><postnatal period><prenatal><prenatal exposure><prenatally exposed><prevent><preventing><prospective><psychiatric illness><psychological disorder><school age><social role><stool><stool sample><stool specimen><substantia alba><temporal cortex><unborn><under served community><underserved community><white matter><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

BRADLEY S PETERSON

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$671,716
FY 2026

Project Title

Pre- and Postnatal Exposure to Air Pollutants and the Gut Microbiome: Implications for Brain Development in Early and Mid-Childhood

Grant Number:

5R01ES035056-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Early life exposure to air pollution (AP), which disproportionately affects underserved communities, is thought to disrupt cognitive, emotional, and behavioral development. Human studies show that exposure during the prenatal and early postnatal periods are associated with developmental del...

Research Terms

<0-11 years old><21+ years old><AD/HD><ADHD><ASD><Active Follow-up><Address><Adult><Adult Human><Affect><Age Months><Air Pollutants><Air Pollution><Amino Acids><Ammon Horn><Animal Model><Animal Models and Related Studies><Anxiety><Archives><Attention deficit hyperactivity disorder><Attenuated><Autism><Autistic Disorder><Bacteroides><Behavioral><Bile Acids><Birth><Blood flow><Brain><Brain Nervous System><Child><Child Youth><Childhood><Children (0-21)><Clostridium><Cognition><Cognitive><Cornu Ammonis><County><DNA seq><DNA sequencing><DNAseq><Data><Development><Developmental Delay><Developmental Delay Disorders><Early Infantile Autism><Emotional><Encephalon><Environmental Exposure><Exposure to><Feces><Functional Metagenomics><Funding><GI microbiome><Generalized Growth><Growth><Health><Hippocampus><Hortega cell><Human><Impairment><Infant><Infantile Autism><Inflammation><Intervention><Investigators><Kanner's Syndrome><Knowledge><Language><Lateral><Latino><Learning Disabilities><Learning disability><Life><Link><Lipid Peroxidation><Lipids><Literature><Longitudinal Studies><Longitudinal Surveys><Los Angeles><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Maternal Health><Maternal Nutrition><Maternal diet><Measures><Mediating><Mediator><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental Depression><Mental disorders><Mental health disorders><Metabolic Pathway><Metagenomics><Microglia><Modern Man><Mothers><Motor><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Neural Development><Neurocognitive><Neurodevelopmental Disorder><Neurological Development Disorder><Nuclear Magnetic Resonance Imaging><Nutritional><Outcome><Oxidative Stress><Parietal Lobe><Parturition><Pathway interactions><Physiology><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Production><Psychiatric Disease><Psychiatric Disorder><Research><Research Personnel><Researchers><Rest><Role><School-Age Population><Short-Chain Fatty Acids><Specific Child Development Disorders><Structure><Temporal Lobe><Testing><Tissue Growth><United States National Institutes of Health><Variant><Variation><Volatile Fatty Acids><Zeugmatography><active followup><adulthood><aminoacid><attenuate><attenuates><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><bacteria in the gut><brain MR imaging><brain MRI><brain magnetic resonance imaging><brain tissue><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><cognitive ability><cognitive assessment><cognitive development><cognitive performance><cognitive testing><cohort><depression><developmental><digestive tract microbiome><early life exposure><economic cost><enteric microbiome><exposed in utero><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal metabolome><fecal sample><feeding><fetal exposure><follow up><follow-up><followed up><followup><frontal cortex><frontal lobe><gastrointestinal microbiome><gitter cell><gut bacteria><gut microbiome><gut microbiome of infant><gut-associated microbiome><hippocampal><in utero exposure><infancy><infant gut microbiome><infantile><intestinal biome><intestinal microbiome><intra-uterine environmental exposure><intrauterine environmental exposure><kids><knowledge base><long-term study><longitudinal outcome studies><longitudinal research study><maternal nutrition during pregnancy><mental illness><mesoglia><metabolic profile><metabolism measurement><metabolomics><metabonomics><microbial><microglial cell><microgliocyte><model of animal><mother nutrition><multi-modality><multidisciplinary><multimodality><myelination><neonate gut microbiome><neurodevelopment><neurodevelopmental disease><neurogenesis><newborn gut microbiome><novel><nutritious><ontogeny><parietal cortex><pathway><pediatric><perivascular glial cell><post-natal period><postnatal><postnatal period><prenatal><prenatal exposure><prenatally exposed><prevent><preventing><prospective><psychiatric illness><psychological disorder><school age><social role><stool><stool sample><stool specimen><substantia alba><temporal cortex><unborn><under served community><underserved community><white matter><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

STEVEN R. GILL

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$666,383
FY 2026

Project Title

Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy

Grant Number:

5R01DE031025-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Early childhood caries (ECC) is the most common chronic childhood disease. Although largely preventable, ECC affects one third of socioeconomically disadvantaged and racial/ethnic minority preschool children in the US. Effectively reducing ECC disparity requires a better understanding of it...

Research Terms

<0-11 years old><1-5 years old><Address><Advisory Committees><Affect><African American><Afro American><Afroamerican><Archives><Bacteria><Biologic Factor><Biological><Biological Factors><Biometrics><Biometry><Biostatistics><Birth><Black><Black race><Caries><Caries prevention><Child><Child Development><Child Youth><Childhood><Children (0-21)><Chronic><Collection><Communicable Diseases><Communities><Computer Models><Computerized Models><Data><Data Sources><Dental><Dental Decay><Dental caries><Development><Disadvantaged minority><Discipline><Disease><Disorder><Disparities><Disparity><Ensure><Environment><Environmental Factor><Environmental Risk Factor><Exposure to><Functional Metagenomics><Fungus Diseases><Genes><Genetic><Goals><Health><Health Disparities Research><Health disparities related research><Human><Immune><Immune Markers><Immunes><Immunologic Factors><Immunologic Markers><Immunological Factors><Infant><Infant Development><Infant and Child Development><Infectious Diseases><Infectious Disorder><Investigators><Life><Life Cycle><Life Cycle Stages><Low income><Machine Learning><Medical><Metagenomics><Methods><Minority><Modeling><Modern Man><Mothers><Mouth microbiome><Mycoses><NIDCR><NIDR><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><Oral><Oral health><Parturition><Pattern><Perinatal><Peripartum><Preschool Child><Prevention><Professional Organizations><Public Health><Race><Races><Racial Group><Research Personnel><Researchers><Risk Factors><S mutans><S. mutans><SES disparity><Saliva><Salivary><Sampling><Severities><Shapes><Socio-economic status><Socioeconomic Status><Socioeconomically disadvantaged><Streptococcus mutans><Task Forces><Testing><Time><Training><Transmission><Underserved Population><Work><adolescent minority><advisory team><biologic><cohort><computational modeling><computational models><computer based models><computer based prediction><computerized modeling><craniofacial><craniofacies><data driven platform><data platform><dental caries prevention><dental health><developmental><disparities in race><disparity due to race><disparity in health><early childhood><early onset><environmental risk><ethnic minority><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><fungal infection><fungus><fungus infection><health disparities science><health disparity><health record><high dimensionality><immune-based biomarkers><immunologic substance><immunological biomarkers><immunological markers><immunological substance><inequality due to race><inequity due to race><infancy><infantile><innovate><innovation><innovative><kids><life course><machine based learning><machine learning based prediction model><machine learning based predictive model><machine learning prediction><machine learning prediction model><machine statistical learning><metagenome sequencing><metagenomic sequencing><microbial><microbial consortia><microbial flora><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microflora><minority children><minority youth><multidisciplinary><multispecies consortia><oral bacteria><oral flora><oral microbial community><oral microbiome><oral microbiota><oral microflora><pediatric><pediatric minority><predictive modeling><prenatal><preschool child (1-5)><professional association><professional membership><professional society><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial minority><racial minority group><racial minority individual><racial minority people><racial minority population><racial origin><racial population><racial subgroup><racially unequal><socio-economic disadvantage><socio-economic disparity><socio-economic inequality><socio-economic inequity><socio-economic position><socio-economically disadvantaged><socio-economically underprivileged><socioeconomic disadvantage><socioeconomic disparity><socioeconomic inequality><socioeconomic inequity><socioeconomic position><socioeconomically underprivileged><statistical and machine learning><success><tool><tooth decay><transmission process><unborn><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><young minority><youngster>
View Full Project Details on NIH Reporter
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Tongtong Wu

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$666,383
FY 2026

Project Title

Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy

Grant Number:

5R01DE031025-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Early childhood caries (ECC) is the most common chronic childhood disease. Although largely preventable, ECC affects one third of socioeconomically disadvantaged and racial/ethnic minority preschool children in the US. Effectively reducing ECC disparity requires a better understanding of it...

Research Terms

<0-11 years old><1-5 years old><Address><Advisory Committees><Affect><African American><Afro American><Afroamerican><Archives><Bacteria><Biologic Factor><Biological><Biological Factors><Biometrics><Biometry><Biostatistics><Birth><Black><Black race><Caries><Caries prevention><Child><Child Development><Child Youth><Childhood><Children (0-21)><Chronic><Collection><Communicable Diseases><Communities><Computer Models><Computerized Models><Data><Data Sources><Dental><Dental Decay><Dental caries><Development><Disadvantaged minority><Discipline><Disease><Disorder><Disparities><Disparity><Ensure><Environment><Environmental Factor><Environmental Risk Factor><Exposure to><Functional Metagenomics><Fungus Diseases><Genes><Genetic><Goals><Health><Health Disparities Research><Health disparities related research><Human><Immune><Immune Markers><Immunes><Immunologic Factors><Immunologic Markers><Immunological Factors><Infant><Infant Development><Infant and Child Development><Infectious Diseases><Infectious Disorder><Investigators><Life><Life Cycle><Life Cycle Stages><Low income><Machine Learning><Medical><Metagenomics><Methods><Minority><Modeling><Modern Man><Mothers><Mouth microbiome><Mycoses><NIDCR><NIDR><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><Oral><Oral health><Parturition><Pattern><Perinatal><Peripartum><Preschool Child><Prevention><Professional Organizations><Public Health><Race><Races><Racial Group><Research Personnel><Researchers><Risk Factors><S mutans><S. mutans><SES disparity><Saliva><Salivary><Sampling><Severities><Shapes><Socio-economic status><Socioeconomic Status><Socioeconomically disadvantaged><Streptococcus mutans><Task Forces><Testing><Time><Training><Transmission><Underserved Population><Work><adolescent minority><advisory team><biologic><cohort><computational modeling><computational models><computer based models><computer based prediction><computerized modeling><craniofacial><craniofacies><data driven platform><data platform><dental caries prevention><dental health><developmental><disparities in race><disparity due to race><disparity in health><early childhood><early onset><environmental risk><ethnic minority><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><fungal infection><fungus><fungus infection><health disparities science><health disparity><health record><high dimensionality><immune-based biomarkers><immunologic substance><immunological biomarkers><immunological markers><immunological substance><inequality due to race><inequity due to race><infancy><infantile><innovate><innovation><innovative><kids><life course><machine based learning><machine learning based prediction model><machine learning based predictive model><machine learning prediction><machine learning prediction model><machine statistical learning><metagenome sequencing><metagenomic sequencing><microbial><microbial consortia><microbial flora><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microflora><minority children><minority youth><multidisciplinary><multispecies consortia><oral bacteria><oral flora><oral microbial community><oral microbiome><oral microbiota><oral microflora><pediatric><pediatric minority><predictive modeling><prenatal><preschool child (1-5)><professional association><professional membership><professional society><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial minority><racial minority group><racial minority individual><racial minority people><racial minority population><racial origin><racial population><racial subgroup><racially unequal><socio-economic disadvantage><socio-economic disparity><socio-economic inequality><socio-economic inequity><socio-economic position><socio-economically disadvantaged><socio-economically underprivileged><socioeconomic disadvantage><socioeconomic disparity><socioeconomic inequality><socioeconomic inequity><socioeconomic position><socioeconomically underprivileged><statistical and machine learning><success><tool><tooth decay><transmission process><unborn><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><young minority><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jin Xiao

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$666,383
FY 2026

Project Title

Understand biological factors underlying early childhood caries disparity from the oral microbiome in early infancy

Grant Number:

5R01DE031025-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Early childhood caries (ECC) is the most common chronic childhood disease. Although largely preventable, ECC affects one third of socioeconomically disadvantaged and racial/ethnic minority preschool children in the US. Effectively reducing ECC disparity requires a better understanding of it...

Research Terms

<0-11 years old><1-5 years old><Address><Advisory Committees><Affect><African American><Afro American><Afroamerican><Archives><Bacteria><Biologic Factor><Biological><Biological Factors><Biometrics><Biometry><Biostatistics><Birth><Black><Black race><Caries><Caries prevention><Child><Child Development><Child Youth><Childhood><Children (0-21)><Chronic><Collection><Communicable Diseases><Communities><Computer Models><Computerized Models><Data><Data Sources><Dental><Dental Decay><Dental caries><Development><Disadvantaged minority><Discipline><Disease><Disorder><Disparities><Disparity><Ensure><Environment><Environmental Factor><Environmental Risk Factor><Exposure to><Functional Metagenomics><Fungus Diseases><Genes><Genetic><Goals><Health><Health Disparities Research><Health disparities related research><Human><Immune><Immune Markers><Immunes><Immunologic Factors><Immunologic Markers><Immunological Factors><Infant><Infant Development><Infant and Child Development><Infectious Diseases><Infectious Disorder><Investigators><Life><Life Cycle><Life Cycle Stages><Low income><Machine Learning><Medical><Metagenomics><Methods><Minority><Modeling><Modern Man><Mothers><Mouth microbiome><Mycoses><NIDCR><NIDR><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><Oral><Oral health><Parturition><Pattern><Perinatal><Peripartum><Preschool Child><Prevention><Professional Organizations><Public Health><Race><Races><Racial Group><Research Personnel><Researchers><Risk Factors><S mutans><S. mutans><SES disparity><Saliva><Salivary><Sampling><Severities><Shapes><Socio-economic status><Socioeconomic Status><Socioeconomically disadvantaged><Streptococcus mutans><Task Forces><Testing><Time><Training><Transmission><Underserved Population><Work><adolescent minority><advisory team><biologic><cohort><computational modeling><computational models><computer based models><computer based prediction><computerized modeling><craniofacial><craniofacies><data driven platform><data platform><dental caries prevention><dental health><developmental><disparities in race><disparity due to race><disparity in health><early childhood><early onset><environmental risk><ethnic minority><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><fungal infection><fungus><fungus infection><health disparities science><health disparity><health record><high dimensionality><immune-based biomarkers><immunologic substance><immunological biomarkers><immunological markers><immunological substance><inequality due to race><inequity due to race><infancy><infantile><innovate><innovation><innovative><kids><life course><machine based learning><machine learning based prediction model><machine learning based predictive model><machine learning prediction><machine learning prediction model><machine statistical learning><metagenome sequencing><metagenomic sequencing><microbial><microbial consortia><microbial flora><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microflora><minority children><minority youth><multidisciplinary><multispecies consortia><oral bacteria><oral flora><oral microbial community><oral microbiome><oral microbiota><oral microflora><pediatric><pediatric minority><predictive modeling><prenatal><preschool child (1-5)><professional association><professional membership><professional society><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial minority><racial minority group><racial minority individual><racial minority people><racial minority population><racial origin><racial population><racial subgroup><racially unequal><socio-economic disadvantage><socio-economic disparity><socio-economic inequality><socio-economic inequity><socio-economic position><socio-economically disadvantaged><socio-economically underprivileged><socioeconomic disadvantage><socioeconomic disparity><socioeconomic inequality><socioeconomic inequity><socioeconomic position><socioeconomically underprivileged><statistical and machine learning><success><tool><tooth decay><transmission process><unborn><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><young minority><youngster>
View Full Project Details on NIH Reporter
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SHARON Marie DONOVAN

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$660,357
FY 2026

Project Title

Elucidating Gene-Environment-Behavior Interactions to Uncover Causal Mechanisms for Obesity in Early Life

Grant Number:

5R01DK138032-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Trajectories leading to childhood obesity result from multifactorial Gene x Environment x Behavior interactions during a period of high developmental plasticity. Defining the causal mechanisms that mediate risk for obesity development in early life and how risk can be modified by psychosocial, conte...

Research Terms

<0-11 years old><5-HT><5-HT pathway><5-HT system><5-Hydroxytryptamine><5HT><5HT transporter><5HTT protein><Adipose tissue><Affect><Application Context><Bayesian Network><Behavior><Behavioral><Biological><Biological Markers><Birth><Body Composition><Child><Child Youth><Childhood><Children (0-21)><Computational Biology><Data><Data Set><Development><Diet><Diet Composition><Dietary Component><Dietary intake><Dimensions><EWAS><Eating><Eating Behavior><Emotional><Emotions><Enteramine><Environment><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Evidence based practice guidelines><Exhibits><Fatty Tissue><Firmicutes><Food Intake><GI microbiome><GWA study><GWAS><Generalized Growth><Genes><Genetic><Genetic Diversity><Genetic Risk><Genetic Variation><Genome><Growth><Health><Hippophaine><Human><Individual><Inflammation><Informal Social Control><Intervention><Knowledge><Life><Link><Maps><Measures><Mediating><Methylation><Modeling><Modern Man><Network Analysis><Nutrition><Obesity><Outcome><Parturition><Pathway Analysis><Pathway interactions><Phenotype><Phylogenetic Analysis><Phylogenetics><Predisposition><Process><Psychosocial Factor><Questionnaires><Regulation><Research><Risk><Risk Factors><Risk-associated variant><Sampling><Self Regulation><Serotonergic System><Serotonin><Susceptibility><System><Systems Biology><Temperament><Testing><Time><Tissue Growth><Training><Tryptophan Metabolism><Tryptophan Metabolism Pathway><Variant><Variation><Weight><Weight Gain><Weight Increase><adipose><adiposity><algorithm development><bio-markers><biobank><biologic><biologic marker><biomarker><biorepository><body weight gain><body weight increase><child adiposity><child obesity><childhood adiposity><childhood obesity><cognitive control><cohort><community microbes><computer biology><contextual factors><corpulence><data integration><developmental><developmental plasticity><dietary><dietary composition><diets><digestive tract microbiome><dopamine system><dysbacteriosis><dysbiosis><dysbiotic><early childhood><early-life nutrition><enteric microbiome><environmental risk><epigenetically><epigenome><epigenome wide association analysis><epigenome-wide association studies><evidence based guidelines><evidence based recommendations><executive control><executive function><fast weight gain><fecal microbial community><fecal microbiota><gastrointestinal microbiome><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><gut microbiome><gut-associated microbiome><improved><indexing><individualized predictions><infancy><infantile><intestinal biome><intestinal microbiome><kids><microbe community><microbial><microbial community><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota composition><microorganism community><network models><neural network><new approaches><novel><novel approaches><novel strategies><novel strategy><obese children><obesity development><obesity during childhood><obesity in children><obesity risk><ontogeny><pathway><pediatric><pediatric obesity><personalized predictions><polymicrobial community><precision nutrition><predict responsiveness><predicting response><prediction algorithm><prevent><preventing><psychosocial variables><rapid growth><rapid weight gain><risk allele><risk for obesity><risk gene><risk genotype><risk loci><risk locus><risk of obesity><risk variant><serotonergic pathway><serotonin pathway><serotonin system><serotonin transporter><sodium-dependent serotonin transporter><sudden weight gain><theories><weights><white adipose tissue><whole genome association analysis><whole genome association study><wt gain><yellow adipose tissue><youngster>
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Conor James McMeniman

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$659,296
FY 2026

Project Title

Chemosensory Mechanisms Driving Malaria Transmission

Grant Number:

5R01AI182234-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/15/2024

End Date:

10/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

To hunt humans and transmit malaria parasites, the African malaria mosquito Anopheles gambiae relies on its sense of smell to track volatile organic compounds emitted by the human body. Human body odor comprises a complex blend of hundreds of airborne chemicals derived from our primary metabolism re...

Research Terms

<Africa South of the Sahara><African><Alcohol Chemical Class><Alcohols><Aldehydes><Alkanes><Anopheles><Anopheles Genus><Anopheles gambiae><Anophelines><Assay><Automobile Driving><Behavior><Bioassay><Biological><Biological Assay><Biological Markers><Bite><Body Temperature><Body part><CO2><Carbon Dioxide><Carbonic Anhydride><Carboxylic Acids><Chemicals><Chemistry><Complex><Cues><Culicidae><Development><Disease Vectors><Engineering><Epidemiology><Esters><Exposure to><Female><Formulation><Functional Metagenomics><Goals><Grant><Heterogeneity><Human><Human Figure><Human Microbiome><Human body><Individual><Infrastructure><Intermediary Metabolism><Ketones><Knowledge><Lactic acid><Length><Malaria><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Metagenomics><Methods><Microbe><Modern Man><Mosquito Control><Mosquito-borne disease><Mosquito-borne infectious disease><Mosquitoes><Motion><Mouth microbiome><Northern Rhodesia><Odors><Olfaction><Paludism><Parasites><Participant><Pathway interactions><Persons><Plasmodium Infections><Population Control><Population Surveillance><Process><Province><Public Health><Public Health Surveillance><Research><Resolution><Reverse engineering><Risk><Role><Sampling><Seasons><Sensory><Series><Shapes><Sight><Site><Skin><Sleep><Smell><Smell Perception><Sub-Saharan Africa><Subsaharan Africa><Supplementation><Survey Instrument><Surveys><Swab><System><Testing><Transmission><Variant><Variation><Vision><Volatilization><Zambia><bio-markers><biologic><biologic marker><biomarker><biomarker identification><candidate identification><cohort><combat><community living><community microbes><comparative><cutaneous microbiome><dermal microbiome><developmental><driving><epidemiologic><epidemiological><epidermal microbiome><human subject><human-associated microbiome><identification of biomarkers><identification of new biomarkers><improved><insight><inter-individual variability><inter-individual variation><malaria mosquito><malaria transmission><marker identification><microbe community><microbial><microbial community><microbiome><microbiome community><microorganism community><multi-modality><multimodality><nasal microbiome><novel><odor perception><olfactory perception><oral microbiome><pathway><polymicrobial community><preference><prevent><preventing><recruit><resolutions><secondary metabolite><sensory mechanism><sinonasal microbiome><skin biome><skin microbiome><social role><synergism><translation strategy><translational approach><translational strategy><transmission process><vector><visual function><volatile organic chemical><volatile organic compound><♀>
View Full Project Details on NIH Reporter
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Elise Chong

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$650,210
FY 2026

Project Title

Targeting Lymphoma: A Multimodal Approach using Radiation, CART-19 Therapy, and Gut Microbiome Modulation

Grant Number:

5R01CA288473-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Our previous groundbreaking research, published in 2020 and 2023, unveiled the remarkable synergy achieved by combining oral Vancomycin with radiation therapy (RT) or Chimeric Antigen Receptor T-cell therapy (CART) in enhancing the antitumor response. This innovative approach exploited Vancomycin's ...

Research Terms

<Adjuvant><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antigen Presentation><Antigen Presentation Pathway><Antigen Processing and Presentation><Antitumor Response><Autologous><B lymphoma><B-Cell Lymphomas><Biopsy><CAR T cell therapy><CAR T therapy><CD19><CD19 gene><Cancer Treatment><Cancers><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chemical Fractionation><Clinical Trials><Collecting Cell><Combined Modality Therapy><Communication><Controlled Clinical Trials><Cross Presentation><Dendritic Cells><Dendritic cell neoplasm><Dendritic cell tumor><Disease><Disorder><Dose><Evaluation><FRACN><Feces><Fractionation><Fractionation Radiotherapy><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Expression><Germinoblastic Sarcoma><Germinoblastoma><Gram-Positive Bacteria><Immune response><Immune system><Investigation><Liquid substance><Lymphatic><Lymphoma><Malignant Cell><Malignant Lymphoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mediating><Mediator><Melanoma Metastasis><Metabolic><Metabolic Pathway><Metastatic Melanoma><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Molecular><Multimodal Therapy><Multimodal Treatment><Murine><Mus><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Network Analysis><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><Oncology><Oncology Cancer><Oral><PBMC><Pathway Analysis><Pathway interactions><Patient Schedules><Patients><Pennsylvania><Peripheral Blood Mononuclear Cell><Phase><Pilot Projects><Population><Predisposition><Progression-Free Survivals><Property><Publishing><Pulmonary Cancer><Pulmonary malignant Neoplasm><Radiation><Radiation Chimera><Radiation therapy><Radiotherapeutics><Radiotherapy><Randomized><Regimen><Relapse><Research><Reticulolymphosarcoma><Role><Route><Safety><Short-Chain Fatty Acids><Subcellular Process><Susceptibility><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cells><T-Lymphocyte><T-cell therapeutics><T-cell transfer therapy><Testing><Toxic effect><Toxicities><Tumor Antigens><Tumor Volume><Tumor-Associated Antigen><Universities><Utah><Vancomycin><Vancomycin Resistance><Veiled Cells><Vesicle><Volatile Fatty Acids><Work><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><anti-cancer therapy><anti-microbial><anti-tumor effect><anti-tumor immune response><anti-tumor response><antimicrobial><antitumor effect><arm><cancer antigens><cancer cell><cancer therapy><cancer-directed therapy><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor T cell therapy><chimeric antigen receptor T therapy><clinical relevance><clinically relevant><combination therapy><combined modality treatment><combined treatment><digestive tract microbiome><disease control><disorder control><effective therapy><effective treatment><enteric microbial community><enteric microbiome><enteric microbiota><experience><experiment><experimental research><experimental study><experiments><fecal sample><fluid><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbiome><host response><immune system response><immunogenic><immunogenic apoptosis><immunogenic cell death><immunogenicity><immunoresponse><improved><in vivo><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><liquid><lung cancer><lung lesion><malignancy><manufacturing process><microbial><microbiome community composition><microbiome composition><microbiome signature><microbiome species composition><microbiome structure><microbiota patterns><microbiota profiles><microbiota signature><mouse model><multi-modal therapy><multi-modal treatment><multi-modality><multimodality><murine model><neoplasm/cancer><new approaches><novel approaches><novel strategies><novel strategy><pathway><pilot study><pilot trial><pre-clinical study><preclinical study><prevent><preventing><primary end point><primary endpoint><pulmonary lesion><radiation treatment><randomisation><randomization><randomly assigned><recruit><resistance to vancomycin><resistant to vancomycin><secondary end point><secondary endpoint><single cell technology><social role><stool><stool sample><stool specimen><synergism><therapeutic T-cell platform><thymus derived lymphocyte><treatment strategy><treatment with radiation><tumor><tumor-specific antigen><vancomycin resistant>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Andrea Facciabene

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$650,210
FY 2026

Project Title

Targeting Lymphoma: A Multimodal Approach using Radiation, CART-19 Therapy, and Gut Microbiome Modulation

Grant Number:

5R01CA288473-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Our previous groundbreaking research, published in 2020 and 2023, unveiled the remarkable synergy achieved by combining oral Vancomycin with radiation therapy (RT) or Chimeric Antigen Receptor T-cell therapy (CART) in enhancing the antitumor response. This innovative approach exploited Vancomycin's ...

Research Terms

<Adjuvant><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antigen Presentation><Antigen Presentation Pathway><Antigen Processing and Presentation><Antitumor Response><Autologous><B lymphoma><B-Cell Lymphomas><Biopsy><CAR T cell therapy><CAR T therapy><CD19><CD19 gene><Cancer Treatment><Cancers><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chemical Fractionation><Clinical Trials><Collecting Cell><Combined Modality Therapy><Communication><Controlled Clinical Trials><Cross Presentation><Dendritic Cells><Dendritic cell neoplasm><Dendritic cell tumor><Disease><Disorder><Dose><Evaluation><FRACN><Feces><Fractionation><Fractionation Radiotherapy><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Expression><Germinoblastic Sarcoma><Germinoblastoma><Gram-Positive Bacteria><Immune response><Immune system><Investigation><Liquid substance><Lymphatic><Lymphoma><Malignant Cell><Malignant Lymphoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mediating><Mediator><Melanoma Metastasis><Metabolic><Metabolic Pathway><Metastatic Melanoma><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Molecular><Multimodal Therapy><Multimodal Treatment><Murine><Mus><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Network Analysis><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><Oncology><Oncology Cancer><Oral><PBMC><Pathway Analysis><Pathway interactions><Patient Schedules><Patients><Pennsylvania><Peripheral Blood Mononuclear Cell><Phase><Pilot Projects><Population><Predisposition><Progression-Free Survivals><Property><Publishing><Pulmonary Cancer><Pulmonary malignant Neoplasm><Radiation><Radiation Chimera><Radiation therapy><Radiotherapeutics><Radiotherapy><Randomized><Regimen><Relapse><Research><Reticulolymphosarcoma><Role><Route><Safety><Short-Chain Fatty Acids><Subcellular Process><Susceptibility><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cells><T-Lymphocyte><T-cell therapeutics><T-cell transfer therapy><Testing><Toxic effect><Toxicities><Tumor Antigens><Tumor Volume><Tumor-Associated Antigen><Universities><Utah><Vancomycin><Vancomycin Resistance><Veiled Cells><Vesicle><Volatile Fatty Acids><Work><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><anti-cancer therapy><anti-microbial><anti-tumor effect><anti-tumor immune response><anti-tumor response><antimicrobial><antitumor effect><arm><cancer antigens><cancer cell><cancer therapy><cancer-directed therapy><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor T cell therapy><chimeric antigen receptor T therapy><clinical relevance><clinically relevant><combination therapy><combined modality treatment><combined treatment><digestive tract microbiome><disease control><disorder control><effective therapy><effective treatment><enteric microbial community><enteric microbiome><enteric microbiota><experience><experiment><experimental research><experimental study><experiments><fecal sample><fluid><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbiome><host response><immune system response><immunogenic><immunogenic apoptosis><immunogenic cell death><immunogenicity><immunoresponse><improved><in vivo><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><liquid><lung cancer><lung lesion><malignancy><manufacturing process><microbial><microbiome community composition><microbiome composition><microbiome signature><microbiome species composition><microbiome structure><microbiota patterns><microbiota profiles><microbiota signature><mouse model><multi-modal therapy><multi-modal treatment><multi-modality><multimodality><murine model><neoplasm/cancer><new approaches><novel approaches><novel strategies><novel strategy><pathway><pilot study><pilot trial><pre-clinical study><preclinical study><prevent><preventing><primary end point><primary endpoint><pulmonary lesion><radiation treatment><randomisation><randomization><randomly assigned><recruit><resistance to vancomycin><resistant to vancomycin><secondary end point><secondary endpoint><single cell technology><social role><stool><stool sample><stool specimen><synergism><therapeutic T-cell platform><thymus derived lymphocyte><treatment strategy><treatment with radiation><tumor><tumor-specific antigen><vancomycin resistant>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Boyu Hu

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$650,210
FY 2026

Project Title

Targeting Lymphoma: A Multimodal Approach using Radiation, CART-19 Therapy, and Gut Microbiome Modulation

Grant Number:

5R01CA288473-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Our previous groundbreaking research, published in 2020 and 2023, unveiled the remarkable synergy achieved by combining oral Vancomycin with radiation therapy (RT) or Chimeric Antigen Receptor T-cell therapy (CART) in enhancing the antitumor response. This innovative approach exploited Vancomycin's ...

Research Terms

<Adjuvant><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antigen Presentation><Antigen Presentation Pathway><Antigen Processing and Presentation><Antitumor Response><Autologous><B lymphoma><B-Cell Lymphomas><Biopsy><CAR T cell therapy><CAR T therapy><CD19><CD19 gene><Cancer Treatment><Cancers><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chemical Fractionation><Clinical Trials><Collecting Cell><Combined Modality Therapy><Communication><Controlled Clinical Trials><Cross Presentation><Dendritic Cells><Dendritic cell neoplasm><Dendritic cell tumor><Disease><Disorder><Dose><Evaluation><FRACN><Feces><Fractionation><Fractionation Radiotherapy><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Expression><Germinoblastic Sarcoma><Germinoblastoma><Gram-Positive Bacteria><Immune response><Immune system><Investigation><Liquid substance><Lymphatic><Lymphoma><Malignant Cell><Malignant Lymphoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mediating><Mediator><Melanoma Metastasis><Metabolic><Metabolic Pathway><Metastatic Melanoma><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Molecular><Multimodal Therapy><Multimodal Treatment><Murine><Mus><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Network Analysis><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><Oncology><Oncology Cancer><Oral><PBMC><Pathway Analysis><Pathway interactions><Patient Schedules><Patients><Pennsylvania><Peripheral Blood Mononuclear Cell><Phase><Pilot Projects><Population><Predisposition><Progression-Free Survivals><Property><Publishing><Pulmonary Cancer><Pulmonary malignant Neoplasm><Radiation><Radiation Chimera><Radiation therapy><Radiotherapeutics><Radiotherapy><Randomized><Regimen><Relapse><Research><Reticulolymphosarcoma><Role><Route><Safety><Short-Chain Fatty Acids><Subcellular Process><Susceptibility><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cells><T-Lymphocyte><T-cell therapeutics><T-cell transfer therapy><Testing><Toxic effect><Toxicities><Tumor Antigens><Tumor Volume><Tumor-Associated Antigen><Universities><Utah><Vancomycin><Vancomycin Resistance><Veiled Cells><Vesicle><Volatile Fatty Acids><Work><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><anti-cancer therapy><anti-microbial><anti-tumor effect><anti-tumor immune response><anti-tumor response><antimicrobial><antitumor effect><arm><cancer antigens><cancer cell><cancer therapy><cancer-directed therapy><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor T cell therapy><chimeric antigen receptor T therapy><clinical relevance><clinically relevant><combination therapy><combined modality treatment><combined treatment><digestive tract microbiome><disease control><disorder control><effective therapy><effective treatment><enteric microbial community><enteric microbiome><enteric microbiota><experience><experiment><experimental research><experimental study><experiments><fecal sample><fluid><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbiome><host response><immune system response><immunogenic><immunogenic apoptosis><immunogenic cell death><immunogenicity><immunoresponse><improved><in vivo><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><liquid><lung cancer><lung lesion><malignancy><manufacturing process><microbial><microbiome community composition><microbiome composition><microbiome signature><microbiome species composition><microbiome structure><microbiota patterns><microbiota profiles><microbiota signature><mouse model><multi-modal therapy><multi-modal treatment><multi-modality><multimodality><murine model><neoplasm/cancer><new approaches><novel approaches><novel strategies><novel strategy><pathway><pilot study><pilot trial><pre-clinical study><preclinical study><prevent><preventing><primary end point><primary endpoint><pulmonary lesion><radiation treatment><randomisation><randomization><randomly assigned><recruit><resistance to vancomycin><resistant to vancomycin><secondary end point><secondary endpoint><single cell technology><social role><stool><stool sample><stool specimen><synergism><therapeutic T-cell platform><thymus derived lymphocyte><treatment strategy><treatment with radiation><tumor><tumor-specific antigen><vancomycin resistant>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Julia Yue Cui

OREGON STATE UNIVERSITY, CORVALLIS, OR

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$645,113
FY 2026

Project Title

Developmental flame retardant exposure, gut microbiome, and obesity

Grant Number:

5R01ES030197-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/12/2025

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Obesity and type-II diabetes are a pandemic, causing grave social and economic burdens in the United States. Epidemiological and animal studies showed that the flame retardants polybrominated diphenyl ethers (PBDEs) and a most widely used current PBDE-alternative – tetrabromobispheno...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><21+ years old><AH Receptors><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Animal Model><Animal Models and Related Studies><Animals><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-diabetic Agents><Anti-diabetic Drugs><Anti-inflammatory><Aryl Hydrocarbon Receptor><Behavioral><Blood Serum><CP34><CYP3><CYP3A><CYP3A4><CYP3A4 gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chemicals><Complex><Cytochrome P-450><Cytochrome P-450 Enzyme System><Cytochrome P450><Cytochrome P450 3A4><Cytochrome P450 Family Gene><Cytochrome P450, Subfamily IIIA, Polypeptide 4><Cytochrome P450PCN1><Development><Diabetes Mellitus><Diet><Dietary Factors><Dioxin Receptors><Disease><Disorder><Economic Burden><Effectiveness><Endocrine><Endocrine disruption><Environmental Factor><Environmental Risk Factor><Epidemiology><Exposure to><FAMILY III P450><Fire Retardants><Flame Retardants><Functional Metagenomics><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Expression><Gene Modified><Genes><Genetic><Genotype><Germ-Free><Gestation><Glucocorticoid-Inducible P450><Grant><Hepatic><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><High Fat Diet><Human><Immune><Immunes><Indoles><Industrialization><Inflammation><Inflammatory><Injury to Liver><Intermediary Metabolism><Intervention><Intestinal><Intestinal Content><Intestinal Leakage><Intestines><Intracellular Communication and Signaling><Isotopes><Ketosis-Resistant Diabetes Mellitus><L-Tryptophan><Leaky Gut><Levotryptophan><Life><Link><Liver><Liver Cells><Maturity-Onset Diabetes Mellitus><Mediating><Mediator><Metabolic Processes><Metabolism><Metagenomics><Mice><Mice Mammals><Microbe><Modern Man><Murine><Mus><NIDDM><Nifedipine Oxidase><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nuclear Receptors><Nuclear Translocator><Obesity><Oral><Organ><Outcome><P450><P450C3><P450PCN1><PXR receptor><Pancreas><Pancreatic><Pathogenesis><Phenotype><Physiologic><Physiological><Polyaromatic Hydrocarbon Receptors><Pregnancy><Prevalence><Propionic Acids><Receptor Activation><Receptor Protein><Receptor Signaling><Research><Risk Factors><Role><Sampling><Serum><Short-Chain Fatty Acids><Shotgun Sequencing><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Steroid-Inducible P450- III><T2 DM><T2D><T2DM><TCDD Receptors><Testing><Thyroid Gland Hormone><Thyroid Hormones><Time><Transgenic Mice><Tryptophan><Tryptophan Metabolism><Tryptophan Metabolism Pathway><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><Volatile Fatty Acids><Weaning><adiposity><adult adiposity><adult obesity><adult onset diabetes><adulthood><adults with obesity><ahr ligand><anti-diabetic><aryl hydrocarbon receptor ligand><biological signal transduction><bowel><bowel inflammation><cell type><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><constitutive androstane receptor><corpulence><developmental><diabetes><diabetic><diet-associated obesity><diet-induced obesity><diet-related obesity><diets><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><early life exposure><endocrine disrupting><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><epidemiologic><epidemiological><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbial flora><gastrointestinal microbiome><gene modification><genetically modified><gut community><gut dysbiosis><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><gut-liver axis><hepatic body system><hepatic damage><hepatic injury><hepatic organ system><high risk><hormone metabolism><human model><inflamed bowel><inflamed gut><inflamed intestine><inflammation marker><inflammatory marker><intestinal biome><intestinal flora><intestinal inflammation><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><ketosis resistant diabetes><later in life><later life><lens><lenses><liver damage><liver injury><maturity onset diabetes><metabolism measurement><metabolomics><metabonomics><microbial><microbial imbalance><microbial signature><microbiome><mimicry><model of animal><model of human><mouse model><murine model><novel><obesigenic><obesogenic><offspring><pandemic><pandemic disease><polybrominated biphenyl ether><polybrominated diphenyl ether><postnatal><pregnane X receptor><prevent><preventing><propanoic acid><pup><receptor><remediation><response><social><social role><species difference><tetrabromobisphenol A><transcriptomics><type 2 DM><type II DM><type two diabetes><western diet><western-style diet><western-type diet>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Haiwei Gu

OREGON STATE UNIVERSITY, CORVALLIS, OR

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$645,113
FY 2026

Project Title

Developmental flame retardant exposure, gut microbiome, and obesity

Grant Number:

5R01ES030197-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/12/2025

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Obesity and type-II diabetes are a pandemic, causing grave social and economic burdens in the United States. Epidemiological and animal studies showed that the flame retardants polybrominated diphenyl ethers (PBDEs) and a most widely used current PBDE-alternative – tetrabromobispheno...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><21+ years old><AH Receptors><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Animal Model><Animal Models and Related Studies><Animals><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-diabetic Agents><Anti-diabetic Drugs><Anti-inflammatory><Aryl Hydrocarbon Receptor><Behavioral><Blood Serum><CP34><CYP3><CYP3A><CYP3A4><CYP3A4 gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chemicals><Complex><Cytochrome P-450><Cytochrome P-450 Enzyme System><Cytochrome P450><Cytochrome P450 3A4><Cytochrome P450 Family Gene><Cytochrome P450, Subfamily IIIA, Polypeptide 4><Cytochrome P450PCN1><Development><Diabetes Mellitus><Diet><Dietary Factors><Dioxin Receptors><Disease><Disorder><Economic Burden><Effectiveness><Endocrine><Endocrine disruption><Environmental Factor><Environmental Risk Factor><Epidemiology><Exposure to><FAMILY III P450><Fire Retardants><Flame Retardants><Functional Metagenomics><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Expression><Gene Modified><Genes><Genetic><Genotype><Germ-Free><Gestation><Glucocorticoid-Inducible P450><Grant><Hepatic><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><High Fat Diet><Human><Immune><Immunes><Indoles><Industrialization><Inflammation><Inflammatory><Injury to Liver><Intermediary Metabolism><Intervention><Intestinal><Intestinal Content><Intestinal Leakage><Intestines><Intracellular Communication and Signaling><Isotopes><Ketosis-Resistant Diabetes Mellitus><L-Tryptophan><Leaky Gut><Levotryptophan><Life><Link><Liver><Liver Cells><Maturity-Onset Diabetes Mellitus><Mediating><Mediator><Metabolic Processes><Metabolism><Metagenomics><Mice><Mice Mammals><Microbe><Modern Man><Murine><Mus><NIDDM><Nifedipine Oxidase><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nuclear Receptors><Nuclear Translocator><Obesity><Oral><Organ><Outcome><P450><P450C3><P450PCN1><PXR receptor><Pancreas><Pancreatic><Pathogenesis><Phenotype><Physiologic><Physiological><Polyaromatic Hydrocarbon Receptors><Pregnancy><Prevalence><Propionic Acids><Receptor Activation><Receptor Protein><Receptor Signaling><Research><Risk Factors><Role><Sampling><Serum><Short-Chain Fatty Acids><Shotgun Sequencing><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Steroid-Inducible P450- III><T2 DM><T2D><T2DM><TCDD Receptors><Testing><Thyroid Gland Hormone><Thyroid Hormones><Time><Transgenic Mice><Tryptophan><Tryptophan Metabolism><Tryptophan Metabolism Pathway><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><Volatile Fatty Acids><Weaning><adiposity><adult adiposity><adult obesity><adult onset diabetes><adulthood><adults with obesity><ahr ligand><anti-diabetic><aryl hydrocarbon receptor ligand><biological signal transduction><bowel><bowel inflammation><cell type><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><constitutive androstane receptor><corpulence><developmental><diabetes><diabetic><diet-associated obesity><diet-induced obesity><diet-related obesity><diets><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><early life exposure><endocrine disrupting><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><epidemiologic><epidemiological><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbial flora><gastrointestinal microbiome><gene modification><genetically modified><gut community><gut dysbiosis><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><gut-liver axis><hepatic body system><hepatic damage><hepatic injury><hepatic organ system><high risk><hormone metabolism><human model><inflamed bowel><inflamed gut><inflamed intestine><inflammation marker><inflammatory marker><intestinal biome><intestinal flora><intestinal inflammation><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><ketosis resistant diabetes><later in life><later life><lens><lenses><liver damage><liver injury><maturity onset diabetes><metabolism measurement><metabolomics><metabonomics><microbial><microbial imbalance><microbial signature><microbiome><mimicry><model of animal><model of human><mouse model><murine model><novel><obesigenic><obesogenic><offspring><pandemic><pandemic disease><polybrominated biphenyl ether><polybrominated diphenyl ether><postnatal><pregnane X receptor><prevent><preventing><propanoic acid><pup><receptor><remediation><response><social><social role><species difference><tetrabromobisphenol A><transcriptomics><type 2 DM><type II DM><type two diabetes><western diet><western-style diet><western-type diet>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sridhar Mani

OREGON STATE UNIVERSITY, CORVALLIS, OR

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$645,113
FY 2026

Project Title

Developmental flame retardant exposure, gut microbiome, and obesity

Grant Number:

5R01ES030197-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/12/2025

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Obesity and type-II diabetes are a pandemic, causing grave social and economic burdens in the United States. Epidemiological and animal studies showed that the flame retardants polybrominated diphenyl ethers (PBDEs) and a most widely used current PBDE-alternative – tetrabromobispheno...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><21+ years old><AH Receptors><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Animal Model><Animal Models and Related Studies><Animals><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-diabetic Agents><Anti-diabetic Drugs><Anti-inflammatory><Aryl Hydrocarbon Receptor><Behavioral><Blood Serum><CP34><CYP3><CYP3A><CYP3A4><CYP3A4 gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chemicals><Complex><Cytochrome P-450><Cytochrome P-450 Enzyme System><Cytochrome P450><Cytochrome P450 3A4><Cytochrome P450 Family Gene><Cytochrome P450, Subfamily IIIA, Polypeptide 4><Cytochrome P450PCN1><Development><Diabetes Mellitus><Diet><Dietary Factors><Dioxin Receptors><Disease><Disorder><Economic Burden><Effectiveness><Endocrine><Endocrine disruption><Environmental Factor><Environmental Risk Factor><Epidemiology><Exposure to><FAMILY III P450><Fire Retardants><Flame Retardants><Functional Metagenomics><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Expression><Gene Modified><Genes><Genetic><Genotype><Germ-Free><Gestation><Glucocorticoid-Inducible P450><Grant><Hepatic><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><High Fat Diet><Human><Immune><Immunes><Indoles><Industrialization><Inflammation><Inflammatory><Injury to Liver><Intermediary Metabolism><Intervention><Intestinal><Intestinal Content><Intestinal Leakage><Intestines><Intracellular Communication and Signaling><Isotopes><Ketosis-Resistant Diabetes Mellitus><L-Tryptophan><Leaky Gut><Levotryptophan><Life><Link><Liver><Liver Cells><Maturity-Onset Diabetes Mellitus><Mediating><Mediator><Metabolic Processes><Metabolism><Metagenomics><Mice><Mice Mammals><Microbe><Modern Man><Murine><Mus><NIDDM><Nifedipine Oxidase><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nuclear Receptors><Nuclear Translocator><Obesity><Oral><Organ><Outcome><P450><P450C3><P450PCN1><PXR receptor><Pancreas><Pancreatic><Pathogenesis><Phenotype><Physiologic><Physiological><Polyaromatic Hydrocarbon Receptors><Pregnancy><Prevalence><Propionic Acids><Receptor Activation><Receptor Protein><Receptor Signaling><Research><Risk Factors><Role><Sampling><Serum><Short-Chain Fatty Acids><Shotgun Sequencing><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Steroid-Inducible P450- III><T2 DM><T2D><T2DM><TCDD Receptors><Testing><Thyroid Gland Hormone><Thyroid Hormones><Time><Transgenic Mice><Tryptophan><Tryptophan Metabolism><Tryptophan Metabolism Pathway><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><Volatile Fatty Acids><Weaning><adiposity><adult adiposity><adult obesity><adult onset diabetes><adulthood><adults with obesity><ahr ligand><anti-diabetic><aryl hydrocarbon receptor ligand><biological signal transduction><bowel><bowel inflammation><cell type><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><constitutive androstane receptor><corpulence><developmental><diabetes><diabetic><diet-associated obesity><diet-induced obesity><diet-related obesity><diets><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><early life exposure><endocrine disrupting><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><epidemiologic><epidemiological><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbial flora><gastrointestinal microbiome><gene modification><genetically modified><gut community><gut dysbiosis><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><gut-liver axis><hepatic body system><hepatic damage><hepatic injury><hepatic organ system><high risk><hormone metabolism><human model><inflamed bowel><inflamed gut><inflamed intestine><inflammation marker><inflammatory marker><intestinal biome><intestinal flora><intestinal inflammation><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><ketosis resistant diabetes><later in life><later life><lens><lenses><liver damage><liver injury><maturity onset diabetes><metabolism measurement><metabolomics><metabonomics><microbial><microbial imbalance><microbial signature><microbiome><mimicry><model of animal><model of human><mouse model><murine model><novel><obesigenic><obesogenic><offspring><pandemic><pandemic disease><polybrominated biphenyl ether><polybrominated diphenyl ether><postnatal><pregnane X receptor><prevent><preventing><propanoic acid><pup><receptor><remediation><response><social><social role><species difference><tetrabromobisphenol A><transcriptomics><type 2 DM><type II DM><type two diabetes><western diet><western-style diet><western-type diet>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Christopher A Gaulke

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$643,212
FY 2026

Project Title

Defining the impact of developmental herbicide exposures on gut microbiome physiology and interactions with health

Grant Number:

5R01ES036174-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/5/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

This project will define how interactions between herbicide exposure, the microbiome, and the host promote adiposity. Billions worldwide are overweight or obese. The gut microbiota regulate host energy metabolism, and imbalance in these communities correlates with increased body mass, adiposity, and...

Research Terms

<2,4-D><2,4-Dichlorophenoxyacetic Acid><Acceleration><Acute><Agricultural Chemicals><Agrochemicals><Animals><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Atrazine><Awareness><BMI><BMI percentile><BMI z-score><Body mass index><Brachydanio rerio><Caloric Intake><Cell Culture Techniques><Chemicals><Communities><Danio rerio><Data><Development><Developmental Diagnostic><Dose><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Early Diagnosis><Early Intervention><Endocrine disruption><Energy Expenditure><Energy Intake><Energy Metabolism><Environment><Exposure to><Functional Metagenomics><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genes><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><Health><Herbicides><Image><Individual><Intermediary Metabolism><Life><Link><Mammalia><Mammalian Cell><Mammals><Measurement><Measures><Mediating><Mediation><Metabolic Drug Detoxications><Metabolic Processes><Metabolism><Metabolism of Toxic Agents><Metagenomics><Microbe><Microbiomics><Miscellaneous Antibiotic><Modeling><Molecular><Multiomic Data><N-(phosphonomethyl)glycine><Negotiating><Negotiation><Obesity><Overweight><PPAR gamma><PPAR-g><PPAR-γ><PPARgamma><PPARγ><Pathway interactions><Pattern><Peroxisome Proliferative Activated Receptor Gamma><Peroxisome Proliferator-Activated Receptor gamma><Peroxisome Proliferator-Activated Receptor γ><Persons><Phenotype><Physiologic><Physiological><Physiology><Quetelet index><Research><Resistance><Role><Sample Size><Series><Shapes><Shotguns><System><Testing><Therapeutic><Thiazolidinedione Receptor><Toxicology><Weight><Weight Gain><Weight Increase><Weights and Measures><Work><Zebra Danio><Zebra Fish><Zebrafish><acute toxicity><adipogenesis><adiposity><body weight gain><body weight increase><caloric dietary content><candidate identification><cell culture><cell cultures><community microbes><corpulence><detoxification><developmental><diagnostic biomarker><diagnostic marker><diet-associated obesity><diet-induced obesity><diet-related obesity><digestive tract microbiome><early detection><early life exposure><endocrine disrupting><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><fat metabolism><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbial flora><gastrointestinal microbiome><gliphosate><glyphosate><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hazard><imaging><in vitro Assay><in vivo><innovate><innovation><innovative><insight><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><later in life><later life><life span><lifespan><lipid biosynthesis><lipid metabolism><lipogenesis><metabolism measurement><metabolomics><metabonomics><metagenome sequencing><metagenomic sequencing><metatranscriptomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial genomics><microbial products><microbiome><microbiome research><microbiome science><microbiome studies><microbiome transplant><microbiome transplantation><microbiota><microbiota transplant><microbiota transplantation><microflora><microorganism community><multiomics><multiple omic data><multiple omics><multispecies consortia><obese individuals><obese people><obese person><obese population><obese subjects><obesigenic><obesity development><obesity management><obesity prevention><obesity risk><obesogenic><operation><operations><panomics><pathway><polymicrobial community><prevent><prevent obesity><preventing><resilience><resilient><resistant><risk for obesity><risk mitigation><risk of obesity><shot gun><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><weights><wt gain>
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Tanya Lynn Alderete

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$632,567
FY 2026

Project Title

Perfluoroalkyl Substances and the Gut Microbiome and Fecal Metabolome: Implications for Obesity Risk in Hispanic Children

Grant Number:

5R01ES035035-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Childhood obesity is a high priority public health issue as it increases the risk of co-morbid diseases, including cardiovascular disease, fatty liver disease, and type 2 diabetes. An improved understanding of the factors that trigger the development of early life obesity is urgently needed...

Research Terms

<0-11 years old><0-4 weeks old><2 year old><2 years of age><21+ years old><Actinomyces><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Age><Age Months><Amino Acids><Archives><BMI><BMI percentile><BMI z-score><Bacteria><Bacteroides><Bile Acids><Biological><Blood><Blood Reticuloendothelial System><Body mass index><Breast Cancer Detection><Breast Feeding><Breast Milk><Breast cancer screening><Breast screening><Breastmilk><California><Canada><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Chemicals><Child><Child Youth><Childhood><Children (0-21)><Data><Development><Disease><Disorder><Dryness><Event><Excretory function><Exposure to><Feeding behaviors><Functional Metagenomics><Funding><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Gestation><Goals><Growth><Heart Vascular><Hispanic><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Human><Human Milk><Human Mother's Milk><Individuals from minority><Individuals of minority><Infant><Ingestive Behavior><Intervention><Investigators><Ketosis-Resistant Diabetes Mellitus><Lactation><Lactobacillus><Life><Link><Lipids><Literature><Longitudinal Studies><Longitudinal Surveys><Mammary Gland Milk><Maternal Health><Maturity-Onset Diabetes Mellitus><Measures><Metabolic Pathway><Metabolic syndrome><Metagenomics><Milk><Minority Groups><Minority People><Minority Population><Minority individual><Modality><Modern Man><Mother's Milk><Mothers><NIDDM><NIH><National Institutes of Health><Newborn Infant><Newborns><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Obesity><Obesity Epidemic><PFAS><Physical activity><Poly-fluoroalkyl substances><Predisposition><Pregnancy><Preventative measure><Preventive measure><Probiotics><Production><Quetelet index><Reporting><Research><Research Personnel><Researchers><Risk><Sampling><Short-Chain Fatty Acids><Slow-Onset Diabetes Mellitus><Source><Spottings><Stable Diabetes Mellitus><Subgroup><Susceptibility><T2 DM><T2D><T2DM><Testing><Tissue Growth><Transmission><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Unhealthy Diet><United States National Institutes of Health><Volatile Fatty Acids><Weight><Youth><Youth 10-21><adipogenesis><adiposity><adult onset diabetes><adulthood><age 2><age 2 years><aged 2 years><aged two years><ages><aminoacid><bacteria in the gut><bile acid metabolism><bile metabolism><biologic><cardiovascular disorder><child adiposity><child obesity><childhood adiposity><childhood obesity><circulatory system><co-morbid><co-morbidity><cohort><comorbidity><corpulence><critical period><developmental><digestive tract microbiome><drinking water><early life exposure><early-onset obesity><energy balance><enteric microbial community><enteric microbiome><enteric microbiota><environmental chemical><excretion><experiment><experimental research><experimental study><experiments><exposed human population><exposed in utero><fatty liver disease><fecal metabolome><fecal sample><feeding-related behaviors><fetal exposure><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiome of infant><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><high risk><human exposure><improved><in utero exposure><infancy><infant gut microbiome><infantile><insight><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intra-uterine environmental exposure><intrauterine environmental exposure><ketosis resistant diabetes><kids><lack of physical activity><lactating><lactational><later in life><later life><lipid biosynthesis><lipogenesis><long-term study><longitudinal outcome studies><longitudinal research study><mammary cancer detection><mammary screening><maternal milk><maturity onset diabetes><metabolism measurement><metabolomics><metabonomics><microbial><multidisciplinary><multiomics><multiple omics><neonate gut microbiome><newborn child><newborn children><newborn gut microbiome><novel><nutrient intake activity><obese children><obesigenic><obesity during childhood><obesity in children><obesity intervention><obesity prevention><obesity risk><obesity therapy><obesity treatment><obesogenic><ontogeny><panomics><pediatric><pediatric obesity><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><physical inactivity><polyfluorinated alkyl substances><polyfluoroalkyl substances><poor diet><postnatal><prenatal><prenatal exposure><prenatally exposed><prevent><prevent obesity><preventing><public health priorities><rapid growth><rapid infant weight gain><risk for obesity><risk of obesity><screening><screenings><stool sample><stool specimen><transmission process><two year old><two years of age><type 2 DM><type II DM><type two diabetes><unborn><under served community><underserved community><weights><youngster><youth age>
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Jeremiah James Faith

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$617,193
FY 2026

Project Title

Uncovering the rules of gut microbiome strain transmission

Grant Number:

5R01DK124133-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/20/2020

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY As biological scientists and even as members of an educated society, we all have some familiarity with the fundamental concept that some aspects of our health are influenced by the set of genes we obtained from our parents. We are also increasingly aware that our body surfaces, from ...

Research Terms

<0-11 years old><21+ years old><Acute><Address><Adult><Adult Human><Algorithms><Awareness><Bacteria><Basic Research><Basic Science><Biological><Biological Response Modifier Therapy><Biological Therapy><Birth><Body Surface><C diff><C difficile><C. diff><C. difficile><Child><Child Youth><Children (0-21)><Clostridioides difficile><Clostridium difficile><Communicable Diseases><Complex><Computational algorithm><Data><Development><Disease><Disorder><Dose><Engraftment><Familiarity><Family><Family member><Feces><Fostering><Frequencies><Functional Metagenomics><Funding><GI commensal><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Taxonomy><Genes><Genome><Grant><Health><Health Status><Human><Immune><Immunes><Individual><Infection><Infectious Diseases><Infectious Disorder><Intestinal><Intestines><Knowledge><Level of Health><Life><MDR organism><MDR pathogen><Metagenomics><Microbe><Modern Man><Monitor><NASH><Parents><Parturition><Pathogenesis><Play><Recurrence><Recurrent><Research Resources><Resources><Role><Route><Sampling><Scientist><Siblings><Skin><Societies><Structure><Taxonomy><Testing><Therapeutic><Therapeutic Trials><Time><Transmission><Transplant Recipients><Ulcerated Colitis><Ulcerative Colitis><Variant><Variation><adulthood><biobank><biologic><biological therapeutic><biological treatment><biologically based therapeutics><biorepository><biotherapeutics><biotherapy><bowel><colonization resistance><commensal bacteria in the gastrointestinal tract><commensal bacteria in the gut><commensal bacteria in the intestine><community microbes><computational framework><computer algorithm><computer framework><developmental><digestive tract microbiome><disease control><disease prevention><disease risk><disorder control><disorder prevention><disorder risk><dosage><enteric commensal><enteric microbial community><enteric microbiome><enteric microbiota><family structure><fecal microbial transplantation><fecal microbiome><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal sample><fecal transplant><fecal transplantation><gastrointestinal commensal><gastrointestinal microbial flora><gastrointestinal microbiome><gut commensal><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><health level><host microbiota><host microflora><human disease><immunogenicity><improved><intestinal biome><intestinal commensal><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kids><later in life><later life><member><microbe community><microbe pathogen><microbial><microbial community><microbial consortia><microbial disease><microbial flora><microbial pathogen><microbial products><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microflora><microorganism community><multi-drug resistant organism><multi-drug resistant pathogen><multidrug resistant organism><multidrug resistant pathogen><multiple drug resistant organism><multiple drug resistant pathogen><multispecies consortia><non-alcohol induced steatohepatitis><non-alcoholic steato-hepatitis><non-alcoholic steatohepatitis><nonalcoholic steato-hepatitis><nonalcoholic steatohepatitis><parent><pathogen><pathogenic microbe><polymicrobial community><resident microbes><resident microflora><social role><stool><stool microbiome><stool sample><stool specimen><stool-associated microbiome><tool><translational study><transmission process><transplant patient><trial design><youngster>
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Ru Chen

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$615,878
FY 2026

Project Title

Elucidating the role of gut microbiota in colitis-associated colorectal cancer

Grant Number:

5R01CA276173-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Patients with ulcerative colitis (UC), an inflammatory bowel disease (IBD), have an increased risk of developing colitis-associated colorectal cancer (CAC). Human gut microbiome composition has recently been associated with a wide array of diseases, including IBD and colorectal cancer. Stud...

Research Terms

<Affect><Animal Model><Animal Models and Related Studies><Apoptosis><Apoptosis Pathway><Bacteria><Bacterial Genes><Bioinformatics><Biologic Models><Biological><Biological Models><Biopsy><Bowel Cancer><Cancer Detection><Cancer Induction><Cancer Treatment><Cancers><Chronic><Clinical><Clinical Research><Clinical Study><Colitis associated colon cancer><Colitis associated colorectal cancer><Colitis induced colorectal cancer><Colon><Colorectal Cancer><DNA Damage><DNA Injury><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Development><Disease><Disorder><Enzyme Gene><Enzymes><Epithelium><Event><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Taxonomy><Genes><Genome Instability><Genomic Instability><Gut Mucosa><Host Factor><Host Factor Protein><Human><Immune response><In Vitro><Individual><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Integration Host Factors><Intermediary Metabolism><Intestinal Cancer><Investigation><Knowledge><Laboratories><Light><Longitudinal Studies><Longitudinal Surveys><Malignant Intestinal Neoplasm><Malignant Intestinal Tumor><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Metabolic Processes><Metabolism><Mice><Mice Mammals><Model System><Modeling><Modern Man><Molecular><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Organoids><Oxidative Stress><Pathogenesis><Pathway interactions><Patients><Photoradiation><Programmed Cell Death><Proliferating><Proteome><Proteomics><Rectum><Research><Research Resources><Research Specimen><Resources><Risk><Role><Sampling><Signal Pathway><Specimen><Structure><Study models><Surface><System><Systems Biology><Taxonomy><Techniques><Technology><Ulcerated Colitis><Ulcerative Colitis><Work><anti-cancer therapy><biologic><cancer prevention><cancer progression><cancer risk><cancer therapy><cancer-directed therapy><carcinogenesis><colitis associated cancer><colitis induced colon cancer><colitis-induced dysbiosis><community microbes><design><designing><developmental><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><fecal microbial community><fecal microbiota><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host response><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiota><immune system response><immunoresponse><in vivo><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><interest><intestinal autoinflammation><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intestine cancer><long-term study><longitudinal outcome studies><longitudinal research study><malignancy><malignant intestine neoplasm><malignant intestine tumor><metaproteomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microbiota composition><microbiota patterns><microbiota profiles><microbiota signature><microflora><microorganism community><model of animal><mouse model><mucosa-associated microbes><mucosa-associated microbial community><mucosa-associated microbiota><mucosal flora><mucosal microbes><mucosal microbiota><mucosal microflora><multispecies consortia><murine model><neoplasm progression><neoplasm/cancer><neoplastic progression><new approaches><new diagnostics><new technology><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation diagnostics><novel approaches><novel diagnostics><novel strategies><novel strategy><novel technologies><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathway><phospho-proteomics><phosphoproteomics><polymicrobial community><protein expression><response><social role><statistics><tool><translational opportunities><translational potential><tumor progression><tumorigenic>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sheng Pan

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$615,878
FY 2026

Project Title

Elucidating the role of gut microbiota in colitis-associated colorectal cancer

Grant Number:

5R01CA276173-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Patients with ulcerative colitis (UC), an inflammatory bowel disease (IBD), have an increased risk of developing colitis-associated colorectal cancer (CAC). Human gut microbiome composition has recently been associated with a wide array of diseases, including IBD and colorectal cancer. Stud...

Research Terms

<Affect><Animal Model><Animal Models and Related Studies><Apoptosis><Apoptosis Pathway><Bacteria><Bacterial Genes><Bioinformatics><Biologic Models><Biological><Biological Models><Biopsy><Bowel Cancer><Cancer Detection><Cancer Induction><Cancer Treatment><Cancers><Chronic><Clinical><Clinical Research><Clinical Study><Colitis associated colon cancer><Colitis associated colorectal cancer><Colitis induced colorectal cancer><Colon><Colorectal Cancer><DNA Damage><DNA Injury><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Development><Disease><Disorder><Enzyme Gene><Enzymes><Epithelium><Event><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Taxonomy><Genes><Genome Instability><Genomic Instability><Gut Mucosa><Host Factor><Host Factor Protein><Human><Immune response><In Vitro><Individual><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Integration Host Factors><Intermediary Metabolism><Intestinal Cancer><Investigation><Knowledge><Laboratories><Light><Longitudinal Studies><Longitudinal Surveys><Malignant Intestinal Neoplasm><Malignant Intestinal Tumor><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Metabolic Processes><Metabolism><Mice><Mice Mammals><Model System><Modeling><Modern Man><Molecular><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Organoids><Oxidative Stress><Pathogenesis><Pathway interactions><Patients><Photoradiation><Programmed Cell Death><Proliferating><Proteome><Proteomics><Rectum><Research><Research Resources><Research Specimen><Resources><Risk><Role><Sampling><Signal Pathway><Specimen><Structure><Study models><Surface><System><Systems Biology><Taxonomy><Techniques><Technology><Ulcerated Colitis><Ulcerative Colitis><Work><anti-cancer therapy><biologic><cancer prevention><cancer progression><cancer risk><cancer therapy><cancer-directed therapy><carcinogenesis><colitis associated cancer><colitis induced colon cancer><colitis-induced dysbiosis><community microbes><design><designing><developmental><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><fecal microbial community><fecal microbiota><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host response><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiota><immune system response><immunoresponse><in vivo><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><interest><intestinal autoinflammation><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intestine cancer><long-term study><longitudinal outcome studies><longitudinal research study><malignancy><malignant intestine neoplasm><malignant intestine tumor><metaproteomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microbiota composition><microbiota patterns><microbiota profiles><microbiota signature><microflora><microorganism community><model of animal><mouse model><mucosa-associated microbes><mucosa-associated microbial community><mucosa-associated microbiota><mucosal flora><mucosal microbes><mucosal microbiota><mucosal microflora><multispecies consortia><murine model><neoplasm progression><neoplasm/cancer><neoplastic progression><new approaches><new diagnostics><new technology><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation diagnostics><novel approaches><novel diagnostics><novel strategies><novel strategy><novel technologies><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathway><phospho-proteomics><phosphoproteomics><polymicrobial community><protein expression><response><social role><statistics><tool><translational opportunities><translational potential><tumor progression><tumorigenic>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Daniel N Frank

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$585,206
FY 2026

Project Title

CRS Microbiome: Multi-omic Integrative Longitudinal Experimental (CRS-MILE) study

Grant Number:

5R01AI175239-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/16/2023

End Date:

10/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY: Chronic rhinosinusitis (CRS) is a highly prevalent disease that inflicts a severe quality-of- life (QOL) impairment. QOL-measures have ranked CRS among severe ailments such as congestive heart failure, chronic obstructive pulmonary disease, and end-stage renal disease. Its high prevalence, ...

Research Terms

<Accessory Sinuses><Activities of Daily Living><Activities of everyday life><Address><Affect><Algorithms><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Attenuated><Autoregulation><Body Tissues><COPD><Cardiac Failure Congestive><Causality><Cell Culture Techniques><Cellular Immune Function><Chronic><Chronic Disease><Chronic Illness><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clinical Management><Communicable Diseases><Communities><Congestive Heart Failure><Data><Development><Disease><Disease Management><Disease Outcome><Disorder><Disorder Management><Dysfunction><ESKD><ESRD><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Epithelial Cells><Epithelium><Etiology><Functional disorder><Goals><Health><Heart Decompensation><High Prevalence><Homeostasis><Host Factor><Host Factor Protein><Human><Immune><Immunes><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Impairment><In Vitro><Infectious Diseases><Infectious Disorder><Inflammation><Inflammatory><Institution><Integration Host Factors><Intervention><Intervention Studies><Kidney Diseases><Knowledge><Laboratories><Lipids><Lipoxins><Measures><Mediating><Mediator><Medical Care Costs><Microbe><Microbiomics><Miscellaneous Antibiotic><Mission><Modern Man><Molecular><Molecular Disease><Mucosa><Mucosal Immunity><Mucosal Inflammation><Mucosal Tissue><Mucositis><Mucous Membrane><NIH><Nasal Sinuses><Nasal cavity/Paranasal><Nasal cavity/Paranasal sinuses><National Institutes of Health><Nature><Nephropathy><Onset of illness><Operative Procedures><Operative Surgical Procedures><Organism><Outcome><P aeruginosa><P. aeruginosa><Paranasal Sinuses><Patients><Phenotype><Physiological Homeostasis><Physiopathology><Population><Process><Prognosis><Pseudomonas aeruginosa><Pseudomonas pyocyanea><Public Health><Publications><Publishing><QOL><Quality of life><Refractory><Renal Disease><Research><Research Specimen><Resolution><Role><S aureus><S. aureus><Sampling><Science><Scientific Publication><Severities><Severity of illness><Sinus><Specimen><Staph aureus><Staphylococcus aureus><Surface><Surgical><Surgical Interventions><Surgical Procedure><Systems Biology><Testing><Therapeutic><Therapeutic Intervention><Tissues><Translating><United States National Institutes of Health><airway microbial community><airway microbiota><alter microbiome><anti-microbial><antimicrobial><attenuate><attenuates><causation><cell culture><cell cultures><cell type><chronic disorder><chronic heart failure><chronic obstructive pulmonary disorder><chronic rhinosinusitis><clinical phenotype><clinical practice><conventional therapy><conventional treatment><cost><daily living function><daily living functionality><developmental><disability><disease causation><disease onset><disease severity><disorder onset><dysbacteriosis><dysbiosis><dysbiotic><functional ability><functional capacity><global gene expression><global transcription profile><host microbe association><host microbe relationship><host microbiome><host-microbe interactions><host-microbial interactions><host-microorganism interactions><human tissue><immune function><improved><innovative technologies><insight><intervention research><intervention therapy><interventional research><interventional study><interventions research><kidney disorder><lipidome><living system><medical costs><medical expenses><metabolome><metabonome><microbial><microbial consortia><microbial flora><microbial host><microbial imbalance><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><microbiome research><microbiome science><microbiome studies><microbiota><microflora><multiomics><multiple omics><multispecies consortia><nasal microbial community><nasal microbiota><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><panomics><pathogen><pathophysiology><prognostic ability><prognostic power><prognostic utility><prognostic value><programs><renal disorder><resolutions><respiratory microbiota><response><response to therapy><response to treatment><restoration><sinonasal microbiota><social role><surgery><therapeutic outcome><therapeutic response><therapy outcome><therapy response><transcriptome><treatment response><treatment responsiveness><treatment strategy>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Vijay Ramakrishnan

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$585,206
FY 2026

Project Title

CRS Microbiome: Multi-omic Integrative Longitudinal Experimental (CRS-MILE) study

Grant Number:

5R01AI175239-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/16/2023

End Date:

10/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY: Chronic rhinosinusitis (CRS) is a highly prevalent disease that inflicts a severe quality-of- life (QOL) impairment. QOL-measures have ranked CRS among severe ailments such as congestive heart failure, chronic obstructive pulmonary disease, and end-stage renal disease. Its high prevalence, ...

Research Terms

<Accessory Sinuses><Activities of Daily Living><Activities of everyday life><Address><Affect><Algorithms><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Attenuated><Autoregulation><Body Tissues><COPD><Cardiac Failure Congestive><Causality><Cell Culture Techniques><Cellular Immune Function><Chronic><Chronic Disease><Chronic Illness><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clinical Management><Communicable Diseases><Communities><Congestive Heart Failure><Data><Development><Disease><Disease Management><Disease Outcome><Disorder><Disorder Management><Dysfunction><ESKD><ESRD><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Epithelial Cells><Epithelium><Etiology><Functional disorder><Goals><Health><Heart Decompensation><High Prevalence><Homeostasis><Host Factor><Host Factor Protein><Human><Immune><Immunes><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Impairment><In Vitro><Infectious Diseases><Infectious Disorder><Inflammation><Inflammatory><Institution><Integration Host Factors><Intervention><Intervention Studies><Kidney Diseases><Knowledge><Laboratories><Lipids><Lipoxins><Measures><Mediating><Mediator><Medical Care Costs><Microbe><Microbiomics><Miscellaneous Antibiotic><Mission><Modern Man><Molecular><Molecular Disease><Mucosa><Mucosal Immunity><Mucosal Inflammation><Mucosal Tissue><Mucositis><Mucous Membrane><NIH><Nasal Sinuses><Nasal cavity/Paranasal><Nasal cavity/Paranasal sinuses><National Institutes of Health><Nature><Nephropathy><Onset of illness><Operative Procedures><Operative Surgical Procedures><Organism><Outcome><P aeruginosa><P. aeruginosa><Paranasal Sinuses><Patients><Phenotype><Physiological Homeostasis><Physiopathology><Population><Process><Prognosis><Pseudomonas aeruginosa><Pseudomonas pyocyanea><Public Health><Publications><Publishing><QOL><Quality of life><Refractory><Renal Disease><Research><Research Specimen><Resolution><Role><S aureus><S. aureus><Sampling><Science><Scientific Publication><Severities><Severity of illness><Sinus><Specimen><Staph aureus><Staphylococcus aureus><Surface><Surgical><Surgical Interventions><Surgical Procedure><Systems Biology><Testing><Therapeutic><Therapeutic Intervention><Tissues><Translating><United States National Institutes of Health><airway microbial community><airway microbiota><alter microbiome><anti-microbial><antimicrobial><attenuate><attenuates><causation><cell culture><cell cultures><cell type><chronic disorder><chronic heart failure><chronic obstructive pulmonary disorder><chronic rhinosinusitis><clinical phenotype><clinical practice><conventional therapy><conventional treatment><cost><daily living function><daily living functionality><developmental><disability><disease causation><disease onset><disease severity><disorder onset><dysbacteriosis><dysbiosis><dysbiotic><functional ability><functional capacity><global gene expression><global transcription profile><host microbe association><host microbe relationship><host microbiome><host-microbe interactions><host-microbial interactions><host-microorganism interactions><human tissue><immune function><improved><innovative technologies><insight><intervention research><intervention therapy><interventional research><interventional study><interventions research><kidney disorder><lipidome><living system><medical costs><medical expenses><metabolome><metabonome><microbial><microbial consortia><microbial flora><microbial host><microbial imbalance><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><microbiome research><microbiome science><microbiome studies><microbiota><microflora><multiomics><multiple omics><multispecies consortia><nasal microbial community><nasal microbiota><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><panomics><pathogen><pathophysiology><prognostic ability><prognostic power><prognostic utility><prognostic value><programs><renal disorder><resolutions><respiratory microbiota><response><response to therapy><response to treatment><restoration><sinonasal microbiota><social role><surgery><therapeutic outcome><therapeutic response><therapy outcome><therapy response><transcriptome><treatment response><treatment responsiveness><treatment strategy>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Eleonore Beurel

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, CORAL GABLES, FL

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$524,579
FY 2026

Project Title

Autoinducer-2 and depression

Grant Number:

5R01MH136006-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Stress often has deleterious effects, particularly in the context of chronic stress, when harm to the individual occurs and often leads to the development of psychiatric diseases. A better understanding of mechanisms mediating stress is critically needed to develop new interventions....

Research Terms

<AI-2 autoinducer><Affect><Bacteria><Behavior><Behavior Control><Behavioral Manipulation><Brain><Brain Nervous System><Cancers><Cardiovascular Diseases><Catecholamine Receptor><Catecholamines><Cell Body><Cell Communication and Signaling><Cell Count><Cell Density><Cell Number><Cell Signaling><Cells><Cellular Immune Function><Chemicals><Chronic stress><Communication><Communities><Complex><Corticosterone><Dendritic Spines><Development><Disease><Disorder><E coli><E. coli><Encephalon><Endocrine Gland Secretion><Engineering><Environment><Escherichia coli><GI microbiome><Hormones><Hortega cell><Immune><Immune response><Immune system><Immunes><Immunity><Individual><Infection><Infiltration><Interleukins><Intervention><Intracellular Communication and Signaling><Knowledge><Malignant Neoplasms><Malignant Tumor><Mediating><Mental Depression><Mental disorders><Mental health disorders><Mice><Mice Mammals><Microbial Biofilms><Microglia><Murine><Mus><N-octanoyl-L-homoserine lactone><Nature><Nerve Cells><Nerve Transmitter Substances><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neuroendocrine><Neuroendocrine System><Neurons><Neurosecretory Systems><Neurotransmitters><Pathway interactions><Physiologic><Physiological><Physiology><Poison><Predisposition><Production><Psychiatric Disease><Psychiatric Disorder><Regulation><Risk><Role><Shotgun Sequencing><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Stress><Susceptibility><Sympathins><System><Testing><Therapeutic><Therapeutic Hormone><Toxic Chemical><Toxic Substance><Transgenic Mice><VAI-2><alter microbiome><autoinducer 2><behavior response><behavioral control><behavioral response><beta-2 Adrenergic Receptors><biofilm><biological adaptation to stress><biological signal transduction><cardiovascular disorder><dendrite spine><density><depression><developmental><digestive tract microbiome><enteric microbiome><gastrointestinal microbiome><gitter cell><gut microbiome><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><host response><immune function><immune system response><immunoresponse><innovate><innovation><innovative><intestinal biome><intestinal microbiome><luminescence><malignancy><mental illness><mesoglia><metabolism measurement><metabolomics><metabonomics><microbial consortia><microbial flora><microbiome adaptation><microbiome alteration><microbiome community composition><microbiome composition><microbiome perturbation><microbiome species composition><microbiome structure><microbiota><microflora><microglial cell><microgliocyte><multispecies consortia><neoplasm/cancer><neurobiological><neuronal><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathway><perivascular glial cell><psychiatric illness><psychological disorder><quorum sensing><reactioncrisis><response><social role><stress related disorder><stress response><stressreaction><toxic compound><β-2 Adrenoceptor><β2 Adrenergic Receptor>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Constantinos G. Broustas

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100
Likely hiring
Solid budget
Active award
Team-scale grant
$495,545
FY 2026

Project Title

Development of a Novel Therapeutic for Mitigating Radiation-Induced Microbiome Dysbiosis and Acute Gastrointestinal Syndrome

Grant Number:

5U01AI172853-04

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY A mass casualty radiation event, such as the detonation of an improvised nuclear device or radiological dispersal device, could lead to severe hemorrhage, multi-organ failure, and infection, potentially leading to sepsis and/or death. The hematopoietic system and the gastrointestinal (GI) tr...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Accidents><Acute><Acute Radiation Syndrome><Address><Affect><Alimentary Canal><Amphoterin><Amphoterin Gene><Animal Model><Animal Models and Related Studies><Animals><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Architecture><Assay><Autoregulation><Bacteria><Bioassay><Biological Assay><Bleeding><Blood monocyte><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><C57BL/6 Mouse><Cell Body><Cell Count><Cell Death><Cell Number><Cells><Cellular injury><Cessation of life><Chromosomal Protein, Nonhistone, HMG1><Chromosomal Protein, Nonhistone, HMG1 Gene><Colon><Death><Development><Devices><Digestive Tract><Dose><Drugs><Dysfunction><Engineering / Architecture><Epithelial Cells><Epithelium><Event><Exposure to><FDA approved><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><FM1 Gene Product><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Functional disorder><Funding><GI Tract><GI commensal><GI microbiota><Gastrointestinal Injury><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><General Radiology><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><HMG-1><HMG-1 Gene><HMG-1 Protein><HMG1><HMG1 Gene><HMG3><HMG3 Gene><HMGB1><HMGB1 Protein><HMGB1 gene><HT-29><HT-29 Cells><HT29 Cells><Hematologic Body System><Hematologic Organ System><Hematopoietic><Hematopoietic Body System><Hematopoietic System><Hemorrhage><Heparin-Binding Protein p30><High Mobility Group Box Protein 1><High Mobility Group Protein 1><High Mobility Group Protein 1 Gene><High-Mobility Group (Nonhistone Chromosomal) Protein 1><High-Mobility Group (Nonhistone Chromosomal) Protein 1 Gene><High-Mobility Group Box 1><High-Mobility Group Box 1 Gene><Homeostasis><Homolog of Drosophila TOLL><Hour><Human><Immune><Immunes><In Vitro><Infection><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Inflammatory Response><Injury><Intestinal><Intestines><Invaded><KO mice><Knock-out Mice><Knockout Mice><LD-50><LD50><Length><Lethal Dose 50><Ligands><Lipopolysaccharides><MOF syndrome><Macrophage><Marrow monocyte><Medication><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Molecular Target><Morphology><Mucosa><Mucosal Tissue><Mucous Membrane><Mucous body substance><Mucus><Multiple Organ Dysfunction Syndrome><Multiple Organ Failure><Murine><Mus><Mφ><Nonhistone Chromosomal Protein HGM1><Nonhistone Chromosomal Protein HGM1 Gene><Nuclear><Null Mouse><Oral Administration><Oral Drug Administration><Pathway interactions><Pattern><Permeability><Pharmaceutical Preparations><Physiological Homeostasis><Physiopathology><Production><Public Health><Radiation><Radiation Accidents><Radiation Dose><Radiation Dose Unit><Radiation Injuries><Radiation Protection><Radiation Toxicity><Radiation exposure><Radiology><Radiology Specialty><Radioprotection><Radioprotective><Radiotoxicity><Resolution><Ribosomal RNA Genes><Role><SBP-1><SBP-1 Gene><Sepsis><Severities><Signal Pathway><Structure><Sulfoglucuronyl Carbohydrate Binding Protein><Sulfoglucuronyl Carbohydrate Binding Protein Gene><Surface><Syndrome><TLR protein><TLR4><TLR4 gene><Testing><Therapeutic><Time><Tissues><Toll Homologue><Toll-Like Receptor Family Gene><Toll-like receptors><Toxic effect><Toxicities><Transgenic Mice><access restrictions><alimentary tract><animal rule><bacterial community><blood loss><bowel><bowel inflammation><cell damage><cell injury><cellular damage><commensal bacteria in the gastrointestinal tract><commensal bacteria in the gut><commensal bacteria in the intestine><commensal flora><commensal microbes><commensal microbiota><commensal microflora><cytokine><damage to cells><determine efficacy><developmental><digestive canal><drug development><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><enteric commensal><enteric microbial community><enteric microbiota><evaluate efficacy><examine efficacy><fecal microbial community><fecal microbiota><gastrointestinal><gastrointestinal commensal><gastrointestinal microbial flora><gut commensal><gut community><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><hemopoietic><improved><in vivo><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><injuries><injury to cells><injury to the intestines><intestinal autoinflammation><intestinal barrier><intestinal commensal><intestinal epithelium><intestinal flora><intestinal inflammation><intestinal injury><intestinal microbiota><intestinal microflora><intestinal mucosal barrier><intestinal tract microflora><intraoral drug delivery><irradiation><irradiation injury><irradiation response><mass casualty><medical countermeasure><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota composition><model of animal><monocyte><mouse model><mucous><multiorgan failure><multiple organ system failure><murine model><necrocytosis><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathogen><pathophysiology><pathway><preservation><public health emergency><rRNA Genes><radiation disaster><radiation effect><radiation event><radiation incident><radiation mitigation><radiation mitigator><radiation poisoning><radiation response><radio-protection><radio-protective><radiological accident><radiological disaster><radiological event><radiological incident><radiological mitigation><radiological mitigator><radiomitigation><radiomitigator><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><resolutions><response><response to radiation><social role><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><timeline><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><toll-like receptor 4><transplant model><treatment group>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Helen C Turner

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100
Likely hiring
Solid budget
Active award
Team-scale grant
$495,545
FY 2026

Project Title

Development of a Novel Therapeutic for Mitigating Radiation-Induced Microbiome Dysbiosis and Acute Gastrointestinal Syndrome

Grant Number:

5U01AI172853-04

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY A mass casualty radiation event, such as the detonation of an improvised nuclear device or radiological dispersal device, could lead to severe hemorrhage, multi-organ failure, and infection, potentially leading to sepsis and/or death. The hematopoietic system and the gastrointestinal (GI) tr...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Accidents><Acute><Acute Radiation Syndrome><Address><Affect><Alimentary Canal><Amphoterin><Amphoterin Gene><Animal Model><Animal Models and Related Studies><Animals><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Architecture><Assay><Autoregulation><Bacteria><Bioassay><Biological Assay><Bleeding><Blood monocyte><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><C57BL/6 Mouse><Cell Body><Cell Count><Cell Death><Cell Number><Cells><Cellular injury><Cessation of life><Chromosomal Protein, Nonhistone, HMG1><Chromosomal Protein, Nonhistone, HMG1 Gene><Colon><Death><Development><Devices><Digestive Tract><Dose><Drugs><Dysfunction><Engineering / Architecture><Epithelial Cells><Epithelium><Event><Exposure to><FDA approved><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><FM1 Gene Product><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Functional disorder><Funding><GI Tract><GI commensal><GI microbiota><Gastrointestinal Injury><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><General Radiology><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><HMG-1><HMG-1 Gene><HMG-1 Protein><HMG1><HMG1 Gene><HMG3><HMG3 Gene><HMGB1><HMGB1 Protein><HMGB1 gene><HT-29><HT-29 Cells><HT29 Cells><Hematologic Body System><Hematologic Organ System><Hematopoietic><Hematopoietic Body System><Hematopoietic System><Hemorrhage><Heparin-Binding Protein p30><High Mobility Group Box Protein 1><High Mobility Group Protein 1><High Mobility Group Protein 1 Gene><High-Mobility Group (Nonhistone Chromosomal) Protein 1><High-Mobility Group (Nonhistone Chromosomal) Protein 1 Gene><High-Mobility Group Box 1><High-Mobility Group Box 1 Gene><Homeostasis><Homolog of Drosophila TOLL><Hour><Human><Immune><Immunes><In Vitro><Infection><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Inflammatory Response><Injury><Intestinal><Intestines><Invaded><KO mice><Knock-out Mice><Knockout Mice><LD-50><LD50><Length><Lethal Dose 50><Ligands><Lipopolysaccharides><MOF syndrome><Macrophage><Marrow monocyte><Medication><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Molecular Target><Morphology><Mucosa><Mucosal Tissue><Mucous Membrane><Mucous body substance><Mucus><Multiple Organ Dysfunction Syndrome><Multiple Organ Failure><Murine><Mus><Mφ><Nonhistone Chromosomal Protein HGM1><Nonhistone Chromosomal Protein HGM1 Gene><Nuclear><Null Mouse><Oral Administration><Oral Drug Administration><Pathway interactions><Pattern><Permeability><Pharmaceutical Preparations><Physiological Homeostasis><Physiopathology><Production><Public Health><Radiation><Radiation Accidents><Radiation Dose><Radiation Dose Unit><Radiation Injuries><Radiation Protection><Radiation Toxicity><Radiation exposure><Radiology><Radiology Specialty><Radioprotection><Radioprotective><Radiotoxicity><Resolution><Ribosomal RNA Genes><Role><SBP-1><SBP-1 Gene><Sepsis><Severities><Signal Pathway><Structure><Sulfoglucuronyl Carbohydrate Binding Protein><Sulfoglucuronyl Carbohydrate Binding Protein Gene><Surface><Syndrome><TLR protein><TLR4><TLR4 gene><Testing><Therapeutic><Time><Tissues><Toll Homologue><Toll-Like Receptor Family Gene><Toll-like receptors><Toxic effect><Toxicities><Transgenic Mice><access restrictions><alimentary tract><animal rule><bacterial community><blood loss><bowel><bowel inflammation><cell damage><cell injury><cellular damage><commensal bacteria in the gastrointestinal tract><commensal bacteria in the gut><commensal bacteria in the intestine><commensal flora><commensal microbes><commensal microbiota><commensal microflora><cytokine><damage to cells><determine efficacy><developmental><digestive canal><drug development><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><enteric commensal><enteric microbial community><enteric microbiota><evaluate efficacy><examine efficacy><fecal microbial community><fecal microbiota><gastrointestinal><gastrointestinal commensal><gastrointestinal microbial flora><gut commensal><gut community><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><hemopoietic><improved><in vivo><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><injuries><injury to cells><injury to the intestines><intestinal autoinflammation><intestinal barrier><intestinal commensal><intestinal epithelium><intestinal flora><intestinal inflammation><intestinal injury><intestinal microbiota><intestinal microflora><intestinal mucosal barrier><intestinal tract microflora><intraoral drug delivery><irradiation><irradiation injury><irradiation response><mass casualty><medical countermeasure><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota composition><model of animal><monocyte><mouse model><mucous><multiorgan failure><multiple organ system failure><murine model><necrocytosis><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathogen><pathophysiology><pathway><preservation><public health emergency><rRNA Genes><radiation disaster><radiation effect><radiation event><radiation incident><radiation mitigation><radiation mitigator><radiation poisoning><radiation response><radio-protection><radio-protective><radiological accident><radiological disaster><radiological event><radiological incident><radiological mitigation><radiological mitigator><radiomitigation><radiomitigator><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><resolutions><response><response to radiation><social role><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><timeline><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><toll-like receptor 4><transplant model><treatment group>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

RADHAKRISHNA RAO

UNIVERSITY OF TENNESSEE HEALTH SCI CTR, MEMPHIS, TN

Good lead · 60/100
Likely hiring
Solid budget
Active award
Team-scale grant
$487,801
FY 2026

Project Title

Mitigation of GI-ARS by Lactobacillus species

Grant Number:

5U01AI172991-04

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/22/2022

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Public radiation exposure due to large-scale radiation incidents is a rising global concern. Gastrointestinal Acute Radiation Syndrome (GI-ARS) is associated with high morbidity and mortality. However, FDA- approved therapeutics for GI-ARS are unavailable. Therefore, outlining the mechanisms of radi...

Research Terms

<ASVSRC1><Actins><Acute Radiation Syndrome><Adenosine Cyclic Monophosphate-Dependent Protein Kinases><Animal Model><Animal Models and Related Studies><Anti-Bacterial Agents><Bacteria><Biological><Biology><C-jun Amino-Terminal Kinase><C-jun Kinase-1><C-jun N-Terminal Kinase 1><CaCo2><Caco-2 Cells><Calcium Phospholipid-Dependent Protein Kinase><Calcium-Activated Phospholipid-Dependent Kinase><Cancer Patient><Cancer Radiotherapy><Cell Body><Cells><Cellular Matrix><Colon><Cyclic AMP-Dependent Protein Kinases><Cytoskeletal System><Cytoskeleton><Data><Diet><Dose><Down-Regulation><Dysfunction><EGF Receptor><EGFR><ERBB Protein><Effectiveness><Endotoxemia><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><Epithelium><Exhibits><Exposure to><FDA approved><Filtration><Filtration Fractionation><Functional disorder><GI microbiome><GI microbiota><Gastrointestinal microbiota><Goals><Gut Epithelium><HDAC><HDAC Proteins><HER1><Histone Deacetylase><Histone Deacetylation><Hour><Human><Intestinal><Intestinal Mucosa><Intestines><Ionizing Electromagnetic Radiation><Ionizing radiation><JN Kinase><JNK><JNK Mitogen-Activated Protein Kinases><JNK1><JNK1 Kinase><JNK1 protein><JNK1A2><JNK21B1/2><KO mice><Knock-out Mice><Knockout Mice><L casei><L plantarum><L. casei><L. plantarum><Lactic acid><Lactobacillus><Lactobacillus casei><Lactobacillus plantarum><MAP Kinase 8><MAP Kinase 8 Gene><MAPK8><MAPK8 Mitogen-Activated Protein Kinase><MAPK8 gene><Mediating><Mice><Mice Mammals><Mitogen-Activated Protein Kinase 8><Modern Man><Molecular><Morbidity><Mouse Strains><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Nuclear Accidents><Null Mouse><Occluding Junctions><Oral Administration><Oral Drug Administration><Organoids><Outcome Study><PKA><PRKM8><Paneth Cells><Pathogenesis><Peptides><Phospholipid-Sensitive Calcium-Dependent Protein Kinase><Physiopathology><Play><Predisposition><Probiotics><Protein Kinase A><Protein Kinase C><Proteins><Qualifying><Radiation><Radiation Accidents><Radiation Enteritis><Radiation Injuries><Radiation Toxicity><Radiation exposure><Radiation-Ionizing Total><Radiotoxicity><Research><Role><SAP Kinase-1><SAPK/JNK><SAPK1 Mitogen-Activated Protein Kinase><SAPK1/JNK><SRC Family Gene><SRC gene><Stress-Activated Protein Kinase JNK1><Stress-Activated Protein Kinase gamma><Survival Rate><Susceptibility><TGF-alpha Receptor><Testing><Therapeutic><Tight Junctions><Time><Transforming Growth Factor alpha Receptor><Tyrosine Phosphorylation><Urogastrone Receptor><Zonula Occludens><alpha-Defensins><alter microbiome><analyze microbiome><animal rule><anti-bacterial><attenuation><biologic><bowel><c src><c-erbB-1><c-erbB-1 Protein><c-jun N-Terminal Kinase><c-src Genes><c-src Proto-Oncogenes><cAMP-Dependent Protein Kinases><cancer radiation therapy><defensin A><diets><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><gastrointestinal><gastrointestinal epithelium><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><insect defensin A><intestinal barrier><intestinal biome><intestinal epithelium><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal mucosal barrier><intestinal tract microflora><intracellular skeleton><intraoral drug delivery><ionizing output><irradiation><irradiation injury><irradiation response><jun-NH2-Terminal Kinase><knockout gene><medical countermeasure><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome adaptation><microbiome alteration><microbiome analysis><microbiome perturbation><microbiota><microbiota composition><microflora><model of animal><monolayer><mortality><mouse model><multispecies consortia><murine model><novel><nuclear disaster><nuclear event><nuclear incident><pathophysiology><probiotic therapeutic><probiotic therapy><probiotic treatment><protein kinase C receptor><proto-oncogene protein c-erbB-1><radiation disaster><radiation event><radiation incident><radiation mitigation><radiation poisoning><radiation response><radiological accident><radiological disaster><radiological event><radiological incident><radiological mitigation><radiomitigation><receptors for activated C kinase><response to radiation><social role><stress-activated protein kinase 1><systemic inflammation><systemic inflammatory response><v-SRC Avian Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog><α-Defensins>
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MARTIN J BLASER

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Good lead · 60/100
Likely hiring
Solid budget
Active award
Team-scale grant
$443,788
FY 2026

Project Title

Microbial, immune, metabolic perturbations by antibiotics (MIME study)

Grant Number:

5U01AI122285-09

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2019

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Over 250 million courses of antibiotics are prescribed annually to out-patients in the United States. The perception that antibiotic use has minimal adverse side effects contributes to their over-use. Since deploying antibiotics seems to be relatively free of toxicity, there are few ...

Research Terms

<21+ years old><Acute><Address><Adult><Adult Human><Affect><After Care><After-Treatment><Aftercare><Amoxicillin><Amoxicilline><Amoxil><Amoxycillin><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Assay><Azadose><Azithromycin><Azitrocin><Azythromycin><Bioassay><Biological><Biological Assay><Blood><Blood Circulation><Blood Plasma><Blood Reticuloendothelial System><Blood leukocyte><Bloodstream><COVID-19><CV-19><Carbohydrates><Circadian Rhythms><Clinical><Clinical Medical Sciences><Clinical Medicine><Cognitive><Communities><Complex><Conduct Clinical Trials><Control Groups><Coronavirus Infectious Disease 2019><Data><Data Analyses><Data Analysis><Development><Diet><Diffuse><Disincentive><Dysfunction><ECG><EKG><EXTMR><Electrocardiogram><Electrocardiography><Energy Expenditure><Energy Metabolism><Enrollment><Evaluation><Exposure to><Extramural><Extramural Activities><Fats><Fatty acid glycerol esters><Functional Metagenomics><Functional disorder><Gene Expression><Gene Transcription><General Taxonomy><Genes><Genetic Transcription><Goals><Health><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Hormonal><Hour><Human><Human Microbiome><Hydroxyampicillin><Immune><Immune Markers><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Markers><Immunological><Immunologically><Immunologics><Immunology><Informatics><Innate Immunity><Intermediary Metabolism><Interruption><Intramural Program><Intramural Research Program><Investigators><Leukocytes><Leukocytes Reticuloendothelial System><Link><Macrolides><Marrow leukocyte><Measurable><Measures><Metabolic><Metabolic Marker><Metabolic Pathway><Metabolic Processes><Metabolism><Metadata><Metagenomics><Miscellaneous Antibiotic><Modeling><Modern Man><NIAID><NIH><National Institute of Allergy and Infectious Disease><National Institutes of Health><Native Immunity><Natural Immunity><Nature><Non-Specific Immunity><Nonspecific Immunity><Nyctohemeral Rhythm><Oral><Out-patients><Outpatients><Participant><Perception><Physiology><Physiopathology><Plasma><Plasma Serum><Polymox><Population><Population Sizes><Procedures><RNA Expression><Radar><Random Allocation><Random Selection><Randomization trial><Regimen><Research><Research Design><Research Personnel><Research Specimen><Researchers><Resistance><Rest><Reticuloendothelial System, Serum, Plasma><Ribosomal RNA Genes><Sampling><Series><Serum Proteins><Shotgun Sequencing><Site><Skin Temperature><Sleep><Specimen><Study Type><Taxonomy><Testing><Therapeutic><Time><Toxic effect><Toxicities><Transcription><Trimox><Twenty-Four Hour Rhythm><Ultreon><United States><United States National Institutes of Health><Urine><Utimox><White Blood Cells><White Cell><Work><Wymox><Zithromax><Zitromax><absorption><adaptive immunity><adult youth><adulthood><alter microbiome><analyze microbiome><bacterial disease treatment><bacterial infectious disease treatment><beta lactam antibiotic><beta-Lactams><biologic><circadian process><circadian rhythmicity><clinical center><clinical significance><clinically significant><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><daily biorhythm><data interpretation><developmental><diets><enroll><fungus><healthy volunteer><human-associated microbiome><immune-based biomarkers><immunological biomarkers><immunological markers><improved><insight><meta data><metagenome><microbial><microbial consortia><microbial flora><microbiome><microbiome adaptation><microbiome alteration><microbiome analysis><microbiome perturbation><microbiota><microflora><model of animal><multiomics><multiple omics><multispecies consortia><oxidation><pandemic><pandemic disease><panomics><pathophysiology><peripheral blood><pharmacologic><post treatment><programs><prospective><rRNA Genes><randomized trial><randomized, clinical trials><recruit><resistant><response><side effect><study design><treatment group><white blood cell><white blood corpuscle><young adult><young adult age><young adulthood><β lactam antibiotic><β-Lactams>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Steven M Holland

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Good lead · 60/100
Likely hiring
Solid budget
Active award
Team-scale grant
$443,788
FY 2026

Project Title

Microbial, immune, metabolic perturbations by antibiotics (MIME study)

Grant Number:

5U01AI122285-09

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2019

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Over 250 million courses of antibiotics are prescribed annually to out-patients in the United States. The perception that antibiotic use has minimal adverse side effects contributes to their over-use. Since deploying antibiotics seems to be relatively free of toxicity, there are few ...

Research Terms

<21+ years old><Acute><Address><Adult><Adult Human><Affect><After Care><After-Treatment><Aftercare><Amoxicillin><Amoxicilline><Amoxil><Amoxycillin><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Assay><Azadose><Azithromycin><Azitrocin><Azythromycin><Bioassay><Biological><Biological Assay><Blood><Blood Circulation><Blood Plasma><Blood Reticuloendothelial System><Blood leukocyte><Bloodstream><COVID-19><CV-19><Carbohydrates><Circadian Rhythms><Clinical><Clinical Medical Sciences><Clinical Medicine><Cognitive><Communities><Complex><Conduct Clinical Trials><Control Groups><Coronavirus Infectious Disease 2019><Data><Data Analyses><Data Analysis><Development><Diet><Diffuse><Disincentive><Dysfunction><ECG><EKG><EXTMR><Electrocardiogram><Electrocardiography><Energy Expenditure><Energy Metabolism><Enrollment><Evaluation><Exposure to><Extramural><Extramural Activities><Fats><Fatty acid glycerol esters><Functional Metagenomics><Functional disorder><Gene Expression><Gene Transcription><General Taxonomy><Genes><Genetic Transcription><Goals><Health><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Hormonal><Hour><Human><Human Microbiome><Hydroxyampicillin><Immune><Immune Markers><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Markers><Immunological><Immunologically><Immunologics><Immunology><Informatics><Innate Immunity><Intermediary Metabolism><Interruption><Intramural Program><Intramural Research Program><Investigators><Leukocytes><Leukocytes Reticuloendothelial System><Link><Macrolides><Marrow leukocyte><Measurable><Measures><Metabolic><Metabolic Marker><Metabolic Pathway><Metabolic Processes><Metabolism><Metadata><Metagenomics><Miscellaneous Antibiotic><Modeling><Modern Man><NIAID><NIH><National Institute of Allergy and Infectious Disease><National Institutes of Health><Native Immunity><Natural Immunity><Nature><Non-Specific Immunity><Nonspecific Immunity><Nyctohemeral Rhythm><Oral><Out-patients><Outpatients><Participant><Perception><Physiology><Physiopathology><Plasma><Plasma Serum><Polymox><Population><Population Sizes><Procedures><RNA Expression><Radar><Random Allocation><Random Selection><Randomization trial><Regimen><Research><Research Design><Research Personnel><Research Specimen><Researchers><Resistance><Rest><Reticuloendothelial System, Serum, Plasma><Ribosomal RNA Genes><Sampling><Series><Serum Proteins><Shotgun Sequencing><Site><Skin Temperature><Sleep><Specimen><Study Type><Taxonomy><Testing><Therapeutic><Time><Toxic effect><Toxicities><Transcription><Trimox><Twenty-Four Hour Rhythm><Ultreon><United States><United States National Institutes of Health><Urine><Utimox><White Blood Cells><White Cell><Work><Wymox><Zithromax><Zitromax><absorption><adaptive immunity><adult youth><adulthood><alter microbiome><analyze microbiome><bacterial disease treatment><bacterial infectious disease treatment><beta lactam antibiotic><beta-Lactams><biologic><circadian process><circadian rhythmicity><clinical center><clinical significance><clinically significant><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><daily biorhythm><data interpretation><developmental><diets><enroll><fungus><healthy volunteer><human-associated microbiome><immune-based biomarkers><immunological biomarkers><immunological markers><improved><insight><meta data><metagenome><microbial><microbial consortia><microbial flora><microbiome><microbiome adaptation><microbiome alteration><microbiome analysis><microbiome perturbation><microbiota><microflora><model of animal><multiomics><multiple omics><multispecies consortia><oxidation><pandemic><pandemic disease><panomics><pathophysiology><peripheral blood><pharmacologic><post treatment><programs><prospective><rRNA Genes><randomized trial><randomized, clinical trials><recruit><resistant><response><side effect><study design><treatment group><white blood cell><white blood corpuscle><young adult><young adult age><young adulthood><β lactam antibiotic><β-Lactams>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sarah E Clark

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$491,669
FY 2026

Project Title

Airway Prevotella enhance innate immune-mediated protection against lung infection

Grant Number:

5R01AI172958-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/20/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary These studies address the large gap in knowledge regarding how commensal bacteria in the airway protect against bacterial pneumonia. Next generation sequencing studies of the airway microbiome have revealed that specific respiratory bacteria are associated with a reduced abundance of...

Research Terms

<(TNF)-α><Address><Alveolar Macrophages><Animal Model><Animal Models and Related Studies><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibiotic Therapy><Antibiotic Treatment><Bacteria><Bacterial Pneumonia><Bacteroides melaninogenicus><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><CD 120a Antigen><CD120a Antigens><CSIF><CSIF-10><Cachectin><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Infiltration><Clinical Treatment><Cytokine Synthesis Inhibitory Factor><D pneumoniae><D. pneumoniae><Data><Development><Digestion><Diplococcus pneumoniae><Exposure to><Goals><Homolog of Drosophila TOLL><Host Factor><Host Factor Protein><Hour><Human><IL-10><IL10><IL10A><Immune><Immune mediated therapy><Immunes><Immunologic Receptors><Immunological Receptors><Immunologically Directed Therapy><Immunotherapeutic agent><Immunotherapy><Individual><Infection><Inflammation><Inflammatory><Inflammatory Response><Injury><Innate Immune Response><Integration Host Factors><Interleukin 10 Precursor><Interleukin-10><Intracellular Communication and Signaling><Invaded><Kinetics><Knowledge><Ligands><Lipopolysaccharides><Lipoproteins><Lobar Pneumonia><Lung><Lung Respiratory System><Lung infections><Macrophage-Derived TNF><Marrow Neutrophil><Mediating><Mice><Mice Mammals><Modern Man><Molecular><Monocyte-Derived TNF><Murine><Mus><Myeloid Cell Activation><Myeloid Cells><NGS Method><NGS system><Neutrophil Activation><Neutrophil Infiltration><Neutrophil Recruitment><Neutrophilic Granulocyte><Neutrophilic Infiltrate><Neutrophilic Leukocyte><Outcome><P melaninogenicus><P. melaninogenicus><Pathology><Pathway interactions><Persons><Phenotype><Pneumococcal Pneumonia><Pneumococcus><Pneumonia><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Predisposition><Prevotella><Prevotella melaninogenica><Prevotella melaninogenicus><Probiotics><Production><Pulmonary Macrophages><Pulmonary Pathology><Receptor Protein><Regulation><Resolution><Respiratory Disease><Respiratory System Disease><Respiratory System Disorder><Role><S pneumoniae><S. pneumoniae><Signal Transduction><Signal Transduction Systems><Signaling><Source><Streptococcus pneumoniae><Susceptibility><TIL4><TLR2><TLR2 gene><TLR2 receptor><TLR4><TLR4 gene><TNF><TNF A><TNF Alpha><TNF Receptor p55><TNF gene><TNF-sR55><TNF-α><TNF-α receptor><TNFA><TNFAR><TNFR p60><TNFR, 55-kD><TNFR, 60-kD><TNFR-I><TNFR1><TNFR55><TNFR60><TNFRSF1A><TNFRSF1A Receptor><TNFRSF1A gene><TNFalpha receptor><TNFα><TNFα receptor><Toll Homologue><Toll-Like Receptor 2><Toll/Interleukin 1 Receptor-Like 4><Toll/Interleukin 1 Receptor-Like 4 Gene><Toll/Interleukin 1 Receptor-Like Protein 4><Translations><Tumor Necrosis Factor><Tumor Necrosis Factor Receptor 1><Tumor Necrosis Factor Receptor 55><Tumor Necrosis Factor-alpha><Vulnerable Populations><Work><airway microbiome><antagonism><antagonist><bacteria pneumonia><bacterial disease treatment><bacterial infectious disease treatment><biological signal transduction><cellular targeting><clinical intervention><clinical relevance><clinical therapy><clinically relevant><co-infection><coinfection><commensal bacteria><commensal bacterial species><community acquired pneumonia><community associated pneumonia><cytokine><defined contribution><design><designing><developmental><host microbiome><immune drugs><immune receptor><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapeutics><immune-based therapies><immune-based treatments><immuno therapy><immunologic therapeutics><immunotherapeutics><immunotherapy agent><improved><infection risk><injuries><lung health><lung microbiome><lung pathology><member><microbial><microbial consortia><microbial flora><microbiota><microflora><model of animal><mouse model><multispecies consortia><murine model><neutrophil><next gen sequencing><next generation sequencing><nextgen sequencing><novel><opportunistic pathogen><overexpress><overexpression><pathway><prevent><preventing><protective effect><pulmonary health><pulmonary infections><pulmonary microbiome><receptor><recruit><resolutions><respiratory><respiratory microbiome><respiratory tract microbiome><restraint><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><synergism><toll-like receptor 4><translation><trial regimen><trial treatment><tumor necrosis factor alpha receptor><tumor necrosis factor receptor 1A><tumor necrosis factor α receptor><vulnerable group><vulnerable individual><vulnerable people>
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Iman Hajirasouliha

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$464,101
FY 2026

Project Title

Improving Metagenomic Analysis with Novel Algorithms and Technologies

Grant Number:

2R35GM138152-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2020

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Microbiomes are diverse ecosystems, critical for ecological studies and human health, consisting of numerous species across known or unexplored domains of life. Metagenomic sequencing is essential for studying microbiomes due to the difficulty of culturing many organisms, addressing the challenge of...

Research Terms

<AI based model><AI language models><AI model><AI system><Activities of Daily Living><Activities of everyday life><Address><Algorithms><Artificial Intelligence><Benchmarking><Best Practice Analysis><Cities><Collaborations><Communities><Computer Reasoning><Computer software><Data><Data Set><Dependence><Ecologic Systems><Ecological Systems><Ecosystem><Face><Functional Metagenomics><Genome><Genomics><Goals><Health><Hi-C><Hong Kong><Hongkong><Human><Human Genome><Life><London><Machine Intelligence><Manuals><Metagenomics><Microbiomics><Modeling><Modern Man><Organism><Reference Standards><Reproducibility><Research><Sampling><Series><Shapes><Software><Surface><Technology><Transformer language model><Validation><Visualization><artificial intelligence language models><artificial intelligence model><artificial intelligence-based model><benchmark><bio-informatics tool><bioinformatics tool><daily living function><daily living functionality><faces><facial><flexibility><flexible><functional ability><functional capacity><human whole genome><improved><innovate><innovation><innovative><insight><large language model><large scale language model><living system><massive scale language models><metagenome><metagenome sequencing><metagenomic sequencing><method development><microbiome><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><model development><model developments><nano pore><nanopore><novel><reconstruction><sequencing platform><success><tool><user-friendly><validations>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Amir Mitchell

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$460,625
FY 2026

Project Title

Interactions underlying resilient bacterial communities and successful colonization of host niches

Grant Number:

5R35GM133775-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2019

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Bacteria naturally inhabit different niches in the human host, such as the gut, and can opportunistically colonize sterile niches, such as tumors. Bacterial success in these complex environments depends on multiple factors that include the niche conditions and interactions with neighboring microorga...

Research Terms

<Address><Area><Bacteria><Bacterial Infections><Bar Codes><Biologic Models><Biological Models><Biotech><Biotechnology><Cancers><Collection><Communities><Complex><Computer Analysis><DNA><Death Rate><Deoxyribonucleic Acid><E coli><E. coli><Environment><Escherichia coli><Generalized Growth><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Growth><Human><In Vitro><Intestinal><Intestines><Malignant Neoplasms><Malignant Tumor><Math Models><Measurement><Microbiomics><Model System><Modern Man><Nature><Pathway interactions><Pattern><Population><Population Dynamics><Process><Property><Recombinant DNA Technology><Research><Solid><Sterility><Testing><Time><Tissue Growth><Work><bacteria infection><bacterial community><bacterial disease><barcode><bowel><community microbes><computational analyses><computational analysis><computer analyses><dynamic system><dynamical system><experience><feeding><functional genomics><genetically engineered><host colonization><in vivo><interdisciplinary approach><malignancy><mathematic model><mathematical model><mathematical modeling><member><microbe community><microbial community><microbiome><microbiome research><microbiome science><microbiome studies><microorganism><microorganism community><mortality rate><multidisciplinary approach><mutant><neoplasm/cancer><ontogeny><pathway><polymicrobial community><resilience><resilient><spatial and temporal><spatial temporal><spatiotemporal><sterile><success><tumor><tumor microbiome><tumor-associated microbiome>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Hyun Koo

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$445,260
FY 2026

Project Title

C. albicans interactions with S. mutans modulate cariogenic biofilm formation and virulence

Grant Number:

5R01DE034383-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2025

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Clinical microbiome studies show that C. albicans, along with elevated levels of S. mutans, in plaque (biofilm) is strongly associated with severe early-childhood caries (S-ECC). Previously, we demonstrated that C. albicans interacts with S. mutans and enhances the accumulation and virulence of plaq...

Research Terms

<0-11 years old><ATP-protein phosphotransferase><Acids><Affect><Apatites><Bacteria><Basal Transcription Factor><Basal transcription factor genes><Behavior><Binding><Biomass><C albicans><C. albicans><C.albicans><Candida albicans><Caries><Cell Body><Cell Wall><Cells><Child><Child Youth><Childhood><Children (0-21)><Clinical><Cost Containment><Cost Control><Data><Dental><Dental Decay><Dental Enamel><Dental caries><Development><Diagnostic><Diffusion><Disease><Disorder><Early Diagnosis><Enamel><Environment><Event><Expression Signature><Filament><Gene Expression Profile><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Glucans><Glucose Polymer><Glucosyltransferases><Goals><Growth><Human><Hyphae><Intermediary Metabolism><Investigation><Kinase Family Gene><Knowledge><Laboratory Study><Lesion><Libraries><Mediating><Metabolic Processes><Metabolism><Microbe><Microbial Biofilms><Microbiomics><Microfluidics><Modeling><Modern Man><Molecular Interaction><Morphogenesis><Mouth Diseases><Mouth microbiome><Nature><Onset of illness><Oral Cavity Disease><Oral Cavity Disorder><Oral Disease><Oral Disorder><Output><Pain><Painful><Pathogenicity><Patients><Phenotype><Play><Polyglucoses><Preventative measure><Preventive measure><Process><Production><Property><Protein Kinase><Public Health><Regulation><Rodent><Rodentia><Rodents Mammals><Role><S mutans><S. mutans><Saliva><Severities><Severity of illness><Streptococcus mutans><Structure><Surface><System><Testing><Tissue Growth><Toddler><Transcription Factor Proto-Oncogene><Transcription factor genes><Virulence><Virulent><biofilm><candidate identification><cariogenic bacteria><cariogenic biofilm><cell type><co-infection><coinfection><cost><demineralization><dental biofilm><developmental><diffused><diffuses><diffusing><diffusions><disease onset><disease severity><disorder onset><early childhood><early detection><exoenzyme><extracellular><feeding><fungus><gene expression pattern><gene expression signature><glycogen synthase a kinase><host microbiota><host microflora><hydroxyalkyl protein kinase><in vivo><insight><kids><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><morphogenetic process><mouth disorder><mutant><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><oral microbiome><pediatric><phosphorylase b kinase kinase><plaque biofilm><prevent><preventing><programs><resident microbes><resident microflora><social role><sugar><tooth decay><tooth enamel><tooth surface><transcription factor><transcriptional profile><transcriptional signature><youngster><µfluidic>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Yolanda Yue Huang

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$434,169
FY 2026

Project Title

Polysaccharide utilization and antimicrobial resistance in abundant gut bacteria

Grant Number:

1R35GM162515-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY The trillions of microbes residing in the human gut play critical roles in health and diseases. One critical function of the gut microbiota is to provide colonization resistance to prevent pathogenic invasion and growth. Ingested and host-synthesized nutrients and antimicrobials are ...

Research Terms

<Anaerobic Bacteria><Antibiotic Resistance><Antimicrobial Resistance><Assay><Atlases><Bar Codes><Bile Acids><Bioassay><Biochemistry><Bioinformatics><Biological Assay><Biological Chemistry><Biological Function><Biological Process><Chromosome Mapping><DNA><Data><Deoxyribonucleic Acid><Development><Diagnostic tests><Dietary Fiber><Discipline><Disease><Disorder><Drug Targeting><Drugs><Environment><Expression Library><Foundations><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Localization><Gene Mapping><Gene Mapping Genetics><Generalized Growth><Genes><Genetic><Glycans><Goals><Growth><Health><Health Benefit><Health Promotion><Human><Ingestion><Intermediary Metabolism><Invaded><Knowledge><Linkage Mapping><Medication><Metabolic Processes><Metabolism><Methods><Microbe><Microbiomics><Mission><Modern Man><Molecular><NIGMS><National Institute of General Medical Sciences><Nutrient><Pathogenicity><Pathway interactions><Pharmaceutical Preparations><Phenotype><Play><Polysaccharides><Population><Prevention><Public Health><Research><Resistance to antibiotics><Resistant to antibiotics><Role><Salutogenesis><Shapes><Sight><Tissue Growth><Total Human and Non-Human Gene Mapping><Vision><anaerobe><anti-microbial><anti-microbial resistant><antibiotic drug resistance><antibiotic resistant><antibiotic tolerance><antimicrobial><bacteria in the gut><barcode><colonization resistance><developmental><digestive tract microbiome><disease diagnosis><drug/agent><enteric microbial community><enteric microbiome><enteric microbiota><fitness><functional genomics><gastrointestinal microbial flora><gastrointestinal microbiome><gene function><genetic mapping><genomic platform><gut bacteria><gut community><gut flora><gut health><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbe association><host microbe relationship><host-microbe interactions><host-microbial interactions><host-microorganism interactions><improved><ingest><interest><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><metagenome><microbial consortia><microbial flora><microbiome research><microbiome science><microbiome studies><microbiota><microbiota composition><microflora><multispecies consortia><novel><ontogeny><overexpress><overexpression><pathway><prevent><preventing><programs><promoting health><resistance to anti-microbial><resistant to antimicrobial><social role><tolerance to antibiotics><tolerate antibiotics><visual function>
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SIYUAN MA

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$433,985
FY 2026

Project Title

Advancing Statistical Methods for Next-Generation Microbiome Data Analytics

Grant Number:

1R35GM162668-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

TITLE: Advancing Statistical Methods for Next-Generation Microbiome Data Analytics Abstract: The focus of our research lab is to support human microbiome research with rigorous, robust, and practical statistical and quantitative methodology. In the next five years, our goals are to address critical ...

Research Terms

<AI language models><AI system><Activities of Daily Living><Activities of everyday life><Address><Artificial Intelligence><Benchmarking><Best Practice Analysis><Bioinformatics><Bionomics><Computer Reasoning><Computer software><Data><Data Analyses><Data Analysis><Data Analytics><Data Bases><Databases><Disease><Disorder><Drugs><Ecology><Epidemiology><Functional dependence><Genes><Genetic><Genomics><Goals><Health><Human Microbiome><In Situ><Machine Intelligence><Measurement><Medication><Methodology><Methods><Microbe><Microbiomics><Modeling><Modernization><Nature><Ortholog><Orthologous Gene><Pharmaceutical Preparations><Phase><Population><Population Heterogeneity><Protocol><Protocols documentation><Research><Role><Sight><Software><Source><Statistical Methods><Structure><Techniques><Testing><Transformer language model><Vision><analytical method><artificial intelligence language models><benchmark><daily living function><daily living functionality><dark matter><data base><data collected in real world><data interpretation><data resource><differential expression><differentially expressed><diverse populations><drug/agent><empowerment><epidemiologic><epidemiological><functional ability><functional capacity><heterogeneous population><human-associated microbiome><improved><large language model><large scale language model><massive scale language models><metatranscriptomics><microbial><microbiome><microbiome research><microbiome science><microbiome studies><next generation><novel><open source><population diversity><public data base><public database><publicly accessible data base><publicly accessible database><publicly available data base><publicly available database><real world data><social role><statistic methods><tool><transcriptional differences><visual function>
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Hannah S Shafaat

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$377,558
FY 2026

Project Title

Metallobiochemistry of Mn/Fe protein cofactors

Grant Number:

2R35GM128852-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT The overarching objective of the PI’s research program is to understand how Nature harnesses new types of transition metal active sites within protein environments to carry out challenging chemical transformations, including selectively breaking unreactive carbon-hydrogen bo...

Research Terms

<Active Sites><Bacteria><Benign><Biochemical><Biological Function><Biological Process><Carbon><Chemicals><Chlamydia><Environment><Enzyme Gene><Enzymes><Fe element><Foundations><GI microbiome><Genus Mycobacterium><Geometry><Goals><H-bond><Human><Hydrogen Bonding><Immune system><Iron><Isomerism><M smegmatis><M tb><M tuberculosis><M. smegmatis><M. tb><M. tuberculosis><Manganese><Metabolic><Metalloproteins><Metals><Methods><Miyagawanella><Mn element><Modeling><Modern Man><Modernization><Mycobacterium><Mycobacterium smegmatis><Mycobacterium tuberculosis><Nature><Ni element><Nickel><Nitrogen><O element><O2 element><Organism><Oxidants><Oxidases><Oxidizing Agents><Oxygen><Pathogenicity><Pathway interactions><Physiologic><Physiological><Property><Proteins><Racemases><Reaction><Reporting><Research><Resistance><Role><Scaffolding Protein><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Structure><Structure-Activity Relationship><Substrate Specificity><Techniques><Transition Elements><Variant><Variation><Work><bacteria pathogen><bacterial pathogen><bedsonia><chemical structure function><cofactor><digestive tract microbiome><electron acceptor><electronic structure><enteric microbiome><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><insight><intestinal biome><intestinal microbiome><isomer><lactic acid bacteria><living system><metalloenzyme><microbiome><mtb><mutant><pathogenic bacteria><pathway><programs><resistant><scaffold><scaffolding><social role><structure function relationship><therapeutic agent development><therapeutic development><therapeutic target><transition metal>
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Louis Jared Cohen

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$371,800
FY 2026

Project Title

Characterization of lectins to understand human microbiome functions and develop live biotherapeutics

Grant Number:

5R01DK135675-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Almost all living cells use specific non-enzymatic carbohydrate binding proteins (e.g. lectins) to recognize carbohydrate ligands for cellular trafficking, signaling and defense. The systematic study of lectins and their carbohydrate ligands has improved our understanding of human he...

Research Terms

<Architecture><Autoregulation><Bacteria><Binding><Bioinformatics><Biological Response Modifier Therapy><Biological Therapy><Blood monocyte><Carbohydrates><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Signaling><Cell-to-Cell Interaction><Cells><Clinical Trials><Colitis><Collaborations><Complex><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Data><Data Set><Dendritic Cells><Disease><Disorder><Dysfunction><Engineering><Engineering / Architecture><Environment><Functional disorder><Future><GI microbiota><Gastrointestinal microbiota><Gene Family><Genes><Glycans><Gnotobiotic><Gnotobiotics><Grant><Health><Homeostasis><Human><Human Microbiome><Immune><Immunes><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal><Intestines><Intracellular Communication and Signaling><Laboratories><Lectin><Length><Libraries><Ligands><Macrophage><Maintenance><Maps><Marrow monocyte><Mediating><Mice><Mice Mammals><Modern Man><Molecular Interaction><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Myeloid Cells><Mφ><New York><PBMC><Patients><Pattern recognition receptor><Peripheral Blood Mononuclear Cell><Persons><Physiological Homeostasis><Physiopathology><Polysaccharides><Population><Preclinical data><Proteins><Regulation><Research><Research Methodology><Research Methods><Research Resources><Resources><Role><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Site><Specificity><Target Populations><Testing><Therapeutic><Veiled Cells><biological signal transduction><biological therapeutic><biological treatment><biologically based therapeutics><biotherapeutics><biotherapy><bowel><carbohydrate binding protein><carbohydrate receptor><cell sorting><cellular targeting><colitis mouse model><colitis murine model><colitis-induced dysbiosis><commensal bacteria><commensal bacterial species><commensal flora><commensal microbes><commensal microbiota><commensal microflora><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><effective therapy><effective treatment><enteric microbial community><enteric microbiota><experiment><experimental research><experimental study><experiments><functional genomics><gastrointestinal homeostasis><gastrointestinal microbial flora><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><host microbe association><host microbe relationship><host-microbe interactions><host-microbial interactions><host-microorganism interactions><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiome><human-associated microbiota><improved><inflammatory disease of the intestine><inflammatory disorder of the intestine><intestinal autoinflammation><intestinal flora><intestinal homeostasis><intestinal microbiota><intestinal microflora><intestinal tract microflora><microbial><microbial consortia><microbial flora><microbiome><microbiome sequencing><microbiota><microflora><monocyte><mouse colitis><mouse model><multispecies consortia><murine colitis><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><pathophysiology><preclinical findings><preclinical information><protein bound carbohydrate><protein complex><research and methods><response><scRNA sequencing><scRNA-seq><screening><screenings><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><structural biology><therapeutic agent development><therapeutic development><trafficking>
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Alyssa K Mezochow

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$196,020
FY 2026

Project Title

Impact of Mechanical Circulatory Support and Microbiome Change on Outcomes in Heart Transplant Recipients

Grant Number:

1K23AI190127-01A1

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/14/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Heart failure is a major cause of morbidity and mortality, with orthotopic heart transplant (OHT) considered the gold standard treatment for those eligible. As a result of improving mechanical circulatory support (MCS) technology, in 2018 the national heart allocation polic...

Research Terms

<Acute><Address><Advisory Committees><Affect><Allogenic><Bacteria><Benchmarking><Best Practice Analysis><Biological Response Modifier Therapy><Biological Specimen Banks><Biological Substance Banks><Biological Therapy><Biometrics><Biometry><Biostatistics><Blood Circulation><Bloodstream><Cardiac Transplantation><Caring><Cessation of life><Characteristics><Clinical><Collection><Complication><Data><Death><Development><Devices><Dose><Education><Educational aspects><Eligibility><Eligibility Determination><Epidemiology><Exposure to><Extracorporeal Membrane Oxygenation><FDA approved><Foundations><Future><GI microbiome><Graft Survival><Grafting Procedure><Heart><Heart Grafting><Heart Transplantation><Heart failure><Heterogeneity><Hospital Admission><Hospitalization><Immune response><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Incidence><Individual><Infection><Infection prevention><International><Intervention><Intra-Aortic Balloon Pumping><Intraaortic Balloon Pumping><Investigators><Knowledge><LVAD><Long-term cohort study><Longitudinal cohort study><Mediating><Mentors><Morbidity><Organ><Organ Transplantation><Organ Transplants><Outcome><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Perfusion><Policies><Population><Prevent infection><Progenitor Cell Transplantation><Prophylactic treatment><Prophylaxis><Prospective cohort><Prospective, cohort study><Protocol Screening><Research><Research Personnel><Researchers><Retrospective cohort><Retrospective cohort study><Risk><Risk Factors><Site><Skin><Solid><Statistical Methods><Stem Cell Transplantation><Stem cell transplant><Task Forces><Technology><Time><Training><Training Programs><Transplant Recipients><Transplantation><advisory team><alter microbiome><analyze microbiome><anti-microbial><antimicrobial><bacterial community><benchmark><biological specimen repository><biological therapeutic><biological treatment><biologically based therapeutics><biosample repository><biospecimen bank><biospecimen repository><biotherapeutics><biotherapy><blood infection><bloodstream infection><cardiac failure><cardiac graft><career><cohort><conference><convention><cutaneous microbiome><dermal microbiome><developmental><digestive tract microbiome><enteric microbiome><epidemiologic><epidemiological><epidermal microbiome><experience><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbiome><graft failure><graft function><gut dysbiosis><gut microbiome><gut-associated microbiome><heart transplant><high risk><host response><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved><improved outcome><infection in the blood><infection of the blood><infection risk><intestinal biome><intestinal microbiome><left ventricular assist device><mechanical cardiac support><mechanical circulatory assist><mechanical circulatory support><mechanical circulatory therapy><mechanical heart support><microbial><microbiome><microbiome adaptation><microbiome alteration><microbiome analysis><microbiome perturbation><mortality><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><optimal therapies><optimal treatments><organ allocation><organ allograft><organ graft><organ xenograft><patient oriented outcomes><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><post-transplant><post-transplantation><posttransplant><posttransplantation><prevent><preventing><progenitor transplantation><programs><prospective><restoration><skin biome><skin microbiome><specimen bank><specimen repository><standard care><standard treatment><statistic methods><stem and progenitor cell transplantations><summit><symposia><symposium><transplant><transplant centers><transplant patient><transplant registry>
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Chinenye Rebecca Dike

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$171,056
FY 2026

Project Title

A Double Blinded Randomized Feasibility Trial on the Use of Plant Based Omega-3-Fatty Acids (Flaxseed) to Improve Inflammation Driven Pain Outcomes in Children with Sickle Cell Anemia

Grant Number:

5K23HL173704-03

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ ABSTRACT Sickle cell disease (SCD) affects millions worldwide, 100,000 individuals in USA, and nearly 1000 children in UAB. Sickle cell anemia (SCA, HbSS or HbSB0 thalassemia) is the most severe form of SCD and is associated with morbidity, mortality, and health care burden. Acute ...

Research Terms

<(TNF)-α><0-11 years old><21+ years old><Acute><Acute Pain><Acutely painful><Adherence><Adult><Adult Human><Adverse effects><Affect><Alabama><American><Analgesia Tests><Anemia><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antioxidants><Atrophic Arthritis><Award><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Benchmarking><Best Practice Analysis><Bioinformatics><Blood Plasma><Cachectin><Caring><Child><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Sciences><Clinical Trials><Clinical Trials Design><Complement><Complement Proteins><Complication><Data><Dedications><Dependence><Diet><Dietary Intervention><Dietary Lignans><Disease><Disorder><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Double-blind trial><Enrollment><Environment><Family><Feasibility Studies><Fiber><Fish Oils><Flax><Flaxseed><Food><Functional Metagenomics><GI microbiome><GI microbiota><Gastroenterologist><Gastrointestinal microbiota><Genotype><Goals><Gustation><HPGF><Hb SS disease><HbAS><HbSS disease><Hemoglobin><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hepatocyte-Stimulating Factor><Hybridoma Growth Factor><Hyperalgesia><Hyperalgesic Sensations><IFN-beta 2><IFNB2><IL-1><IL-6><IL1><IL6 Protein><Immunology><Individual><Inflammation><Ingestion><Institution><Intake><Interleukin I><Interleukin-1><Interleukin-6><Intervention><Intervention Studies><K23 Award><K23 Mechanism><K23 Program><Lead><Lignans><Link><Linseed><Linum><Linum usitatissimum><Lymphocyte-Stimulating Hormone><MGI-2><Macrophage Cell Factor><Macrophage-Derived TNF><Measures><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentorship><Metagenomics><Mice><Mice Mammals><Microbial Taxonomy><Monitor><Monocyte-Derived TNF><Morbidity><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Myeloid Differentiation-Inducing Protein><N-3 polyunsaturated fatty acid><Nociception Tests><Nutrition><Nutrition Interventions><Nutritional Interventions><Obesity><Odors><Omega-3 Fatty Acids><Omega-3 PUFA><Omega-3 Polyunsaturated Fatty Acid><Opiates><Opioid><Organ><Outcome><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Therapy><Pain management><Pain measure><Painful><Participant><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patients><Pattern><Pb element><Perception><Physicians><Plant Sources><Plants><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Population><Property><Prospective Studies><Psychology><QOL><Quality of life><Questionnaires><Randomized><Regimen><Reporting><Research><Research Infrastructure><Reticuloendothelial System, Serum, Plasma><Rheumatoid Arthritis><Risk><Scientist><Seafood Oil><Sickle Cell Anemia><Sickle Cell Trait><Source><Supplementation><T Helper Factor><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Taste><Taste Perception><Testing><Thalassemia><Training><Translational Research><Translational Science><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Universities><Work><adiposity><adulthood><arm><benchmark><bowel inflammation><career><chronic pain><clinical center><complementation><corpulence><diet intervention><dietary><dietary approach><dietary manipulation><diets><digestive tract microbiome><drug adherence><drug compliance><dysbacteriosis><dysbiosis><dysbiotic><enroll><enteric microbial community><enteric microbiome><enteric microbiota><enterolactone><feasibility trial><flax seed><gastrointestinal microbial flora><gastrointestinal microbiome><gustatory perception><gustatory processing><gustatory response><gut community><gut dysbiosis><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><health care burden><heavy metal Pb><heavy metal lead><hyperalgia><improved><improved outcome><inflamed bowel><inflamed gut><inflamed intestine><inflammation marker><inflammatory marker><ingest><interferon beta 2><intervention research><interventional research><interventional study><interventions research><intestinal biome><intestinal flora><intestinal inflammation><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kids><life span><lifespan><lymphocyte activating factor><marine><marine environment><medical college><medical schools><medication adherence><medication compliance><metabolism measurement><metabolomics><metabonomics><microbial><microbial imbalance><microbial signature><microbiome><microbiota patterns><microbiota profiles><microbiota signature><mortality><n-3 Fatty Acids><n-3 PUFA><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><nutritional approach><omega-3><omega-3s><opioid sparing><pain assay><pain intervention><pain outcome><pain reduction><pain treatment><pain-related outcome><pediatric><pediatric department><prospective><prospective research study><prospective survey><randomisation><randomization><randomly assigned><recruit><reduce pain><rheumatic arthritis><school of medicine><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><side effect><skill acquisition><skill development><statistics><success><taste processing><taste response><translation research><translational investigation><willingness><youngster>
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Vaibhav Upadhyay

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$169,020
FY 2026

Project Title

Impact of gut bacterial metabolites on lung function and disease

Grant Number:

5K08HL165106-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Acute respiratory distress syndrome (ARDS), the most severe form of acute lung injury (ALI), is common in COVID-19 and was a major driver of the now >1 million deaths in the USA since March 2020. Rigorous work has emphasized the key role the immune system and the microbiome ...

Research Terms

<3 Hydroxybutyrate><ARDS><Ablation><Acute Lung Injury><Acute Pulmonary Injury><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Adult ARDS><Adult RDS><Adult Respiratory Distress Syndrome><Advisory Committees><Alveolar><Area><Bacteria><Bifidobacterium><Biology><Blood Serum><COVID-19><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><CV-19><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Cessation of life><Clinical><Communication><Coronavirus Infectious Disease 2019><Coupled><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Da Nang Lung><Data><Data Analyses><Data Analysis><Death><Disease><Disorder><Foundations><Future><GI microbiome><Generalized Growth><Genes><Germ-Free><Gnotobiotic><Gnotobiotics><Grant><Growth><Gut Epithelium><Health><Human><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immune system><Impairment><In Situ><In Vitro><Inflammation><Inflammatory><Injury><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Ketone Bodies><Ketones><Knowledge><Laboratories><Learning><Link><Liquid substance><Lobar Pneumonia><Lung><Lung Diseases><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lung damage><Measurement><Measures><Mediating><Mentors><Mice><Mice Mammals><Microbiology><Microbiomics><Modeling><Modern Man><Molecular><Murine><Mus><NHLBI><National Heart, Lung, and Blood Institute><Organism><Pathology><Pathway interactions><Patients><Phenotype><Physicians><Physiologic><Physiological><Play><Pneumococcal Pneumonia><Pneumonia><Position><Positioning Attribute><Pulmonary Diseases><Pulmonary Disorder><Research><Research Infrastructure><Research Resources><Resources><Role><Scientist><Serum><Severities><Shock Lung><Stiff lung><Strategic vision><Structure of parenchyma of lung><Subcellular Process><T-Cells><T-Lymphocyte><Task Forces><Technology><Testing><Tissue Growth><Training><Work><advisory team><bacteria in the gut><bacteria metabolism><bacterial metabolism><beta-Hydroxybutyrate><career><career development><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><data interpretation><digestive tract microbiome><disease of the lung><disorder of the lung><enteric microbiome><experiment><experimental research><experimental study><experiments><fluid><gastrointestinal epithelium><gastrointestinal microbiome><gut bacteria><gut microbiome><gut-associated microbiome><immune function><in vivo><injuries><innovate><innovation><innovative><intestinal biome><intestinal epithelium><intestinal microbiome><ketogenic><ketogentic><liquid><living system><lung disorder><lung function><lung injury><microbiome><microbiome research><microbiome science><microbiome studies><microorganism><ontogeny><pathway><programs><pulmonary><pulmonary damage><pulmonary function><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><response><skills><small molecule><social role><thymus derived lymphocyte><tool><training opportunity><wet lung><β-Hydroxybutyrate>
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Kale S Bongers

UNIVERSITY OF IOWA, IOWA CITY, IA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$166,428
FY 2026

Project Title

The Role of the Gut Microbiome in Post-Sepsis Skeletal Muscle Atrophy

Grant Number:

5K08AR083015-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This K08 proposal outlines the plan for Kale Bongers, M.D. Ph.D.’s to complete training toward his long-term goal of improving our understanding of post-sepsis muscle atrophy and weakness through investigation of the microbiome. Dr. Bongers is a physician-scientist in Pulmonary and C...

Research Terms

<Affect><Anabolism><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Atrophic><Atrophy><Award><Bacteria><Biology><Bionomics><Blood><Blood Reticuloendothelial System><Body Tissues><Calibration><Cessation of life><Complement><Complement Proteins><Critical Care><Critical Illness><Critically Ill><Data><Death><Debility><Development><Development Plans><Doctor of Medicine><Doctor of Pharmacy><Doctor of Philosophy><Drug Therapy><Dysfunction><Early Intervention><Ecology><Financial cost><Five-Year Plans><Foundations><Functional Metagenomics><Functional disorder><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Expression><Germ-Free><Goals><Health><Hospital Admission><Hospitalization><Human><Hypertrophy><Immune><Immunes><In Vitro><Infection><Intestinal><Intestines><Investigation><Investigators><Kale><Kale - dietary><Left><Lower GI Tract><Lower Gastrointestinal Tract><M.D.><Measures><Mediating><Mediator><Medical><Medicine><Mentors><Mentorship><Metabolic><Metabolic Pathway><Metagenomics><Mice><Mice Mammals><Michigan><Microbiomics><Miscellaneous Antibiotic><Modern Man><Morbidity><Murine><Mus><Muscle><Muscle Atrophy><Muscle Fibers><Muscle Tissue><Muscle Weakness><Muscular Atrophy><Muscular Weakness><Myotubes><Obesity><Organ><Outcome><Output><Pathogenesis><Patients><Ph.D.><PhD><Pharm.D.><PharmD><Pharmacological Treatment><Pharmacotherapy><Physical Rehabilitation><Physicians><Physiopathology><Play><Productivity><Publishing><QOL><Quality of life><Regulation><Research><Research Personnel><Researchers><Rhabdomyocyte><Risk><Role><Scientist><Secondary to><Sepsis><Severities><Short-Chain Fatty Acids><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Supplementation><Survivors><Swab><Techniques><Testing><Therapeutic><Tissues><Training><Translating><United States><Universities><Variant><Variation><Volatile Fatty Acids><Voluntary Muscle><Work><adiposity><after sepsis><after septic><antisepsis treatment><bacteria in the gut><bacterial disease treatment><bacterial infectious disease treatment><biosynthesis><bowel><career development><complementation><corpulence><developmental><digestive tract microbiome><drug intervention><drug treatment><endurance exercise><enteric microbial community><enteric microbiome><enteric microbiota><exercise capacity><experience><experiment><experimental research><experimental study><experiments><following sepsis><following septic><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><improved><in vitro Model><in vivo><in vivo Model><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><metabolism measurement><metabolomics><metabonomics><microbial><microbiome><microbiome research><microbiome science><microbiome studies><model of animal><monetary cost><mortality><mouse model><murine model><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle metabolism><muscle physiology><muscle wasting><muscular><pathophysiology><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><physical rehab><post sepsis><post septic><post-doctoral training><prevent><preventing><pulmonary><response><sepsis care><sepsis interventions><sepsis management><sepsis survivor><sepsis survivorship><sepsis therapeutics><sepsis therapy><sepsis treatment><septic survival><septic survivor><septic therapy><septic treatment><skeletal muscle atrophy><skeletal muscle breakdown><skeletal muscle loss><skeletal muscle protein loss><skeletal muscle wasting><skill acquisition><skill development><skills><social role><success><survive sepsis><treat sepsis>
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Zheng Wang

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$165,639
FY 2026

Project Title

Multiomics analysis of the microbiome and subclinical cardiovascular disease in HIV infection

Grant Number:

5K01HL169019-03

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This K01 Career Development Award application proposes a multidisciplinary 5-year training program to provide the candidate, Dr. Zheng Wang, with the experience and resources necessary to launch a successful career as an independent investigator. The training plan, developed closely ...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><4E-BP1><ABCD-3><AIDS Virus><ASCVD><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Follow-up><Advisory Committees><Affect><Algorithms><Anti-HIV Positivity><Area><Arterial Fatty Streak><Atheroma><Atheromatous><Atheromatous degeneration><Atheromatous plaque><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Bacteria><Bacterial Infections><Biological Markers><Blood Serum><Blood Vessels><Body Tissues><Buccal Cavity><Buccal Cavity Head and Neck><C fusiforme><C. fusiforme><C3Xkine><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CX3CL1><CX3CL1 gene><CXC3><CXC3C><Cardiac><Cardiomyopathies><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Carotid Artery Plaques><Carotid Atheroscleroses><Carotid Atherosclerotic Disease><Cavitas Oris><Cell Count><Cell Number><Ch'i><Cohort Studies><Corynebacterium fusiforme><Data><Development><Drugs><EIF4EBP1><EIF4EBP1 gene><F fusiformis><F nucleatum><F nucleatus><F. fusiformis><F. nucleatum><F. nucleatus><Functional Metagenomics><Fusiformis fusiformis><Fusiformis nucleatus><Fusobacterium><Fusobacterium nucleatum><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gram-Negative Anaerobic Bacteria><HAART><HIV><HIV Infections><HIV Positive><HIV Positivity><HIV Seroconversion><HIV Seropositivity><HIV antibody positive><HIV disease status><HIV individuals><HIV infected individuals><HIV infected persons><HIV infection status><HIV load><HIV people><HIV plasma viral load><HIV positive individuals><HIV positive people><HIV serostatus><HIV status><HIV viral burden><HIV viral infection><HIV viral load><HIV virus infection><HIV+><HIV-1><HIV-1 infection><HIV-1 load><HIV-1 viral burden><HIV-1 viral load><HIV-I><HIV1><HIV1 infection status><HIV1 status><HTLV-III Seroconversion><HTLV-III Seropositivity><Heart Vascular><Highly Active Antiretroviral Therapy><Histidine><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Immunity><Individual><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Inflammation><Inflammatory><Intermediary Metabolism><Intervention><Investigators><K-Awards><K-Series Research Career Programs><LAV-HTLV-III><Life Expectancy><Link><Lymphadenopathy-Associated Virus><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Mentors><Metabolic Processes><Metabolism><Metagenomics><Morbidity><Mouth><Mouth microbiome><Myocardial><Myocardial Diseases><Myocardial Disorder><Myocardial depression><Myocardial dysfunction><Myocardiopathies><NMR Imaging><NMR Tomography><Nuclear Magnetic Resonance Imaging><Oral><Oral cavity><Oscines><PLWH><PWH><Participant><Pathology><Patients><Persons><Pharmaceutical Preparations><Physiology><Play><Population><Predicting Risk><Prevention><Prize><Proteins><Proteome><Proteomics><Qi><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Career Program><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Risk Factors><Role><SCYD1><Serum><Shotgun Sequencing><Shotguns><Songbirds><Source><Sphaerophorus><T4 Cells><T4 Lymphocytes><Task Forces><The Multi-center AIDS Cohort Study><The Multicenter AIDS Cohort Study><Therapeutic><Tissues><Training><Training Programs><Virus-HIV><Woman><Women's Interagency HIV Study><Work><Zeugmatography><active followup><advisory team><alter microbiome><analyze microbiome><atheromatosis><atherosclerosis plaque><atherosclerotic disease><atherosclerotic lesions><atherosclerotic plaque><atherosclerotic vascular disease><bacteria in the gut><bacteria infection><bacteria pathogen><bacterial disease><bacterial pathogen><bio-markers><biologic marker><biomarker><cardiac MRI><cardiac dysfunction><cardiac magnetic resonance imaging><cardiovascular disease epidemiology><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder epidemiology><cardiovascular disorder risk><cardiovascular epidemiology><career><carotid plaque><circulatory system><cohort><cohort research study><cohort survey><commensal community><commensal microbiome><commensal species><developmental><digestive tract microbiome><drug/agent><enteric microbial community><enteric microbiome><enteric microbiota><experience><follow up><follow-up><followed up><followup><forecasting risk><forest><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heart dysfunction><highly active antiretroviral treatment><human flora><human immunodeficiency virus infection><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiota><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><inflammation marker><inflammatory marker><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><life span><lifespan><men><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metagenome sequencing><metagenomic sequencing><microbial><microbial consortia><microbial flora><microbiome><microbiome adaptation><microbiome alteration><microbiome analysis><microbiome perturbation><microbiota><microflora><mortality><multidisciplinary><multiomics><multiple omics><multispecies consortia><myocardium disease><myocardium disorder><novel><oral bacteria><oral flora><oral microbial community><oral microbiome><oral microbiota><oral microflora><panomics><pathogenic bacteria><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><plaques in atherosclerosis><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><prospective><resident commensals><risk prediction><risk predictions><saliva sample><salivary sample><segregation><shot gun><social role><song bird><ultrasound><vascular>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Erica N Grodin

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$150,837
FY 2026

Project Title

Characterizing the Microbiome-Gut-Brain Axis in Individuals with Alcohol Use Disorder

Grant Number:

5K01AA029712-05

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract This K01 Mentored Research Scientist Development Award is designed to prepare the candidate to become an independent investigator in the emerging field of the gut microbiome in alcohol use disorder (AUD). AUD is a chronic relapsing disease with a major public health impact....

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Alcohol Chemical Class><Alcoholic><Alcohols><Animal Model><Animal Models and Related Studies><Anxiety><Autoregulation><Award><Bacteria><Beverages><Big Data><BigData><Biological Markers><Blood Sample><Blood Serum><Blood specimen><Boozer><CNS Nervous System><Cell Body><Cells><Central Nervous System><Chronic><Clinical><Clinical assessments><Corpus Striatum><Corpus striatum structure><Cues><Data><Dependent drinker><Development><Emotional><Executive Dysfunction><Executive Function Deficit><Executive Impairment><FABP2><FABP2 gene><FABPI><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Goals><Growth><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><Homeostasis><Human><I-FABP><Individual><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Investigation><Investigators><K01 Award><K01 Mechanism><K01 Program><Link><Machine Learning><Mental Depression><Mentored Research Scientist Development Award><Mentored Training Award><Mentors><Methods><Modeling><Modern Man><Neuraxis><Neurosciences><Participant><Pathogenesis><Phenotype><Physiological Homeostasis><Position><Positioning Attribute><Process><Public Health><Recurrent disease><Relapsed Disease><Research><Research Personnel><Research Scientist Development Award><Researchers><Role><Sampling><Scientist><Serum><Striate Body><Striatum><Testing><Tissue Growth><Training><Work><addiction><addictive disorder><alcohol craving><alcohol cue><alcohol related cue><alcohol response><alcohol use disorder><analyze microbiome><bacteria in the gut><bacteria pathogen><bacterial pathogen><bio-markers><biologic marker><biomarker><brain based><chronic EtOH drinking><chronic alcohol consumption><chronic alcohol drinking><chronic alcohol ingestion><chronic alcohol use><chronic ethanol consumption><chronic ethanol drinking><chronic ethanol ingestion><cue reactivity><depression><design><designing><develop therapy><developmental><digestive tract microbiome><disease control><disorder control><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><ethanol craving><ethanol cue><ethanol response><ethanol use disorder><experience><fecal sample><gastrointestinal homeostasis><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><incentive salience><intervention development><intestinal biome><intestinal flora><intestinal homeostasis><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><machine based learning><microbial><microbial consortia><microbial flora><microbial imbalance><microbiome analysis><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microbiota-gut-brain axis><microbiota-gut-brain interactions><microbiota-gut-brain signaling><microflora><model of animal><multispecies consortia><neural><neural circuit><neural circuitry><neural imaging><neuro-imaging><neurocircuitry><neuroimaging><neurological imaging><non-alcoholic><nonalcoholic><ontogeny><pathogenic bacteria><phenomenological models><phenomenology><pre-clinical><preclinical><problem drinker><random forest><response to alcohol><response to ethanol><social role><stool sample><stool specimen><striatal><synaptic circuit><synaptic circuitry><therapy development><treatment development>
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Jonathan Brent Clayton

UNIVERSITY OF NEBRASKA OMAHA, OMAHA, NE

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$126,733
FY 2026

Project Title

A Model of Antibiotic-induced Gut Dysbiosis and Depressive Symptomatology

Grant Number:

5K01OD030514-05

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Emerging microbiota-gut-brain axis research demonstrates an important role of gut microbes in the establishment and treatment of nervous system disorders, including depression. An estimated 300 million or nearly 4% of the human population suffers from depression globally. Depression ...

Research Terms

<Aeroseb-HC><Anhedonia><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Appetite><Behavior><Behavioral><Biological><Brain><Brain Nervous System><Callithrix><Callithrix jacchus><Callithrix jacchus jacchus><Cetacort><Clinical Research><Clinical Study><Clinical Treatment><Common Marmoset><Communication><Complex><Control Groups><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Data><Data Analyses><Data Analysis><Dermacort><Desire for food><Development><Disease><Disorder><EXTMR><Eldecort><Emotional Depression><Encephalon><Endocrine><Endocrine Gland Secretion><Event><Extramural><Extramural Activities><Fluoxetin><Fluoxetine><Funding><GI microbiome><GI microbiota><Gastrointestinal microbiota><Goals><Hapale><Hormones><Human><Hydrocortisone><Hydrocortone><Hytone><Immune><Immune system><Immunes><Inflammatory><Intervention><Investigators><K01 Award><K01 Mechanism><K01 Program><Knowledge acquisition><Life><Marmosets><Measures><Mental Depression><Mentored Research Scientist Development Award><Mentored Training Award><Mentorship><Metabolic><Miscellaneous Antibiotic><Modeling><Modern Man><Morbidity><Multiomic Data><NHP models><Neomycin><Nervous System Diseases><Nervous System Disorder><Neurobiology><Neuroendocrine><Neuroendocrine System><Neurologic Disorders><Neurological Disorders><Neurosecretory Systems><Nutracort><Pathologic><Patients><Persons><Physiologic><Physiological><Population><Predisposition><Probiotics><Proctocort><Production><Prozac><Research><Research Personnel><Research Scientist Development Award><Researchers><Risk><Rodent Model><Role><Short-Tusked Marmoset><Signal Pathway><Social Characteristics><Social Controls><Social isolation><Study models><Susceptibility><Testing><Therapeutic><Therapeutic Effect><Therapeutic Hormone><Training><Vancomycin><animal model development><anti-depressant agent><anti-depressant drugs><anti-depressants><anti-depressive agents><anti-microbial><antimicrobial><bacteria in the gut><bacteria metabolism><bacterial disease treatment><bacterial infectious disease treatment><bacterial metabolism><biologic><clinical intervention><clinical therapy><cytokine><data interpretation><depression><depression symptom><depressive><depressive behavior><depressive symptoms><design><designing><developmental><dietary><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><epidemiology research study><epidemiology study><epidemiology survey><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><inflammation marker><inflammatory marker><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><metabolism measurement><metabolomics><metabonomics><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota-gut-brain axis><microbiota-gut-brain interactions><microbiota-gut-brain signaling><model of animal><multiple omic data><neurobiological><neurological disease><neuropsychiatric disease><neuropsychiatric disorder><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><nonhuman primate models><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><prevent><preventing><skills><social role><social separation><stressor><symptomatology><translational model><trial regimen><trial treatment><vocalization><white ear-tufted marmoset><white-tufted marmoset>
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Curtis Huttenhower

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 54/100
Large award
Recent
Active award
Team-scale grant
$2,903,140
FY 2026

Project Title

A consortium facilitation, coordination, and data management center for the HVP

Grant Number:

5U24HL175772-02

Activity Code:

U24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/15/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

The Human Virome Project (HVP) is an ambitious initiative aimed at characterizing the lesser- explored communities of bacteriophage and eukaryotic viruses associated with the human body, collectively known as the virome. While the virome's impact on human well-being is comparable to the more extensi...

Research Terms

<Address><Advocacy><Assay><Bacteria><Bacteriophages><Bioassay><Biological Assay><Collaborations><Communication><Communities><Computer Analysis><Computer software><Data><Data Analyses><Data Analysis><Data Bases><Data Management Core><Data Set><Databases><Dedications><Democracy><Disease><Disorder><Documentation><Education><Education and Outreach><Educational aspects><Educational workshop><Ensure><Equity><Event><Feedback><Funding><Generations><Genomics><Goals><Health><Human><Human Figure><Human Microbiome><Human Resources><Human body><Individual><Infrastructure><Instruction and Outreach><Investigators><Knowledge><Liquid substance><Manpower><Metadata><Methodology><Methods><Mission><Modality><Modern Man><Monitor><Multiomic Data><NIH><National Institutes of Health><Personal Satisfaction><Phages><Policies><Procedures><Process><Quality Control><Relationship-Building><Reproducibility><Research><Research Personnel><Research Resources><Researchers><Resources><Role><Science><Secure><Self-Help Groups><Software><Support Groups><Training><Training Activity><Training and Outreach><Tutoring and Outreach><United States National Institutes of Health><Viral><Virus><Visualization><Work><Workshop><analyze microbiome><bacterial microbiome><bacterial virus><bacteriome><cloud storage><cloud-based storage><community engagement><computational analyses><computational analysis><computational resources><computer analyses><computing resources><data base><data deposition><data dissemination><data ecosystem><data ingestion><data interpretation><data management><data management and coordinating center><data management center><data portal><data resource><data sharing ecosystem><data sharing portal><data submission><design><designing><engagement with communities><experience><fluid><human virome><human-associated microbiome><improved><liquid><meeting><meetings><member><meta data><microbiome><microbiome analysis><multiomics><multiple omic data><multiple omics><new approaches><novel><novel approaches><novel strategies><novel strategy><operation><operations><outreach><panomics><personnel><programs><self help organization><social integration><social role><tool><training module><viral microbiome><virome><virus host interaction><web site><webinar><website><well-being><wellbeing><work group><working group>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Owen R White

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 54/100
Large award
Recent
Active award
Team-scale grant
$2,903,140
FY 2026

Project Title

A consortium facilitation, coordination, and data management center for the HVP

Grant Number:

5U24HL175772-02

Activity Code:

U24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/15/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

The Human Virome Project (HVP) is an ambitious initiative aimed at characterizing the lesser- explored communities of bacteriophage and eukaryotic viruses associated with the human body, collectively known as the virome. While the virome's impact on human well-being is comparable to the more extensi...

Research Terms

<Address><Advocacy><Assay><Bacteria><Bacteriophages><Bioassay><Biological Assay><Collaborations><Communication><Communities><Computer Analysis><Computer software><Data><Data Analyses><Data Analysis><Data Bases><Data Management Core><Data Set><Databases><Dedications><Democracy><Disease><Disorder><Documentation><Education><Education and Outreach><Educational aspects><Educational workshop><Ensure><Equity><Event><Feedback><Funding><Generations><Genomics><Goals><Health><Human><Human Figure><Human Microbiome><Human Resources><Human body><Individual><Infrastructure><Instruction and Outreach><Investigators><Knowledge><Liquid substance><Manpower><Metadata><Methodology><Methods><Mission><Modality><Modern Man><Monitor><Multiomic Data><NIH><National Institutes of Health><Personal Satisfaction><Phages><Policies><Procedures><Process><Quality Control><Relationship-Building><Reproducibility><Research><Research Personnel><Research Resources><Researchers><Resources><Role><Science><Secure><Self-Help Groups><Software><Support Groups><Training><Training Activity><Training and Outreach><Tutoring and Outreach><United States National Institutes of Health><Viral><Virus><Visualization><Work><Workshop><analyze microbiome><bacterial microbiome><bacterial virus><bacteriome><cloud storage><cloud-based storage><community engagement><computational analyses><computational analysis><computational resources><computer analyses><computing resources><data base><data deposition><data dissemination><data ecosystem><data ingestion><data interpretation><data management><data management and coordinating center><data management center><data portal><data resource><data sharing ecosystem><data sharing portal><data submission><design><designing><engagement with communities><experience><fluid><human virome><human-associated microbiome><improved><liquid><meeting><meetings><member><meta data><microbiome><microbiome analysis><multiomics><multiple omic data><multiple omics><new approaches><novel><novel approaches><novel strategies><novel strategy><operation><operations><outreach><panomics><personnel><programs><self help organization><social integration><social role><tool><training module><viral microbiome><virome><virus host interaction><web site><webinar><website><well-being><wellbeing><work group><working group>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Eleonore Beurel

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, CORAL GABLES, FL

Good lead · 52/100
Likely hiring
Solid budget
Active award
$499,894
FY 2026

Project Title

Adolescent exposure to PCBs as a risk factor for the development of depression

Grant Number:

5R01ES036983-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/17/2024

End Date:

10/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT This proposal addresses an urgent need to understand and analyze the impact of environmental factors on the development of psychiatric diseases, such as depression. Adolescents are particularly vulnerable to both developing depression and health impacts of environmental exposures. Emerging ...

Research Terms

<0-11 years old><12-20 years old><2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><AH Receptors><Acceleration><Actinobacteria><Actinobacteria class><Actinomycetes><Address><Adolescence><Adolescent><Adolescent Youth><Affect><American male><American man><American men><Appetite><Approaches to prevention><Aryl Hydrocarbon Receptor><BBB disruption><Bacteria><Biota><Blood - brain barrier anatomy><Blood brain barrier dysfunction><Blood-Brain Barrier><Brain><Brain Nervous System><Cancer Causing Agents><Carcinogens><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Child><Child Youth><Children (0-21)><Chronic><Coliform Bacilli><Contamination in food><Data><Data Set><Depressive Syndromes><Depressive disorder><Desire for food><Development><Dioxin Receptors><Disease><Disorder><Drug Therapy><Ecological impact><Emotional Depression><Encephalon><Enteric Bacteria><Enterobacteria><Enterobacteriaceae><Environment><Environmental Exposure><Environmental Factor><Environmental Health><Environmental Health Science><Environmental Impact><Environmental Risk Factor><Environmental Toxin><Epidemiology><Event><Exposure to><Food Contamination><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Goals><Health><Hemato-Encephalic Barrier><High G+C Gram-Positive Bacteria><Human><Individual><Inflammatory Response><Inherited Predisposition><Inherited Susceptibility><Intervention><Intracellular Communication and Signaling><Knowledge><Laboratories><Life Expectancy><Major Depressive Disorder><Medical><Mental Depression><Mental disorders><Mental health disorders><Mice><Mice Mammals><Modern Man><Murine><Mus><Nuclear Translocator><Oncogens><Oral><Outcome><PCBs><Persons><Pharmacological Treatment><Pharmacotherapy><Polyaromatic Hydrocarbon Receptors><Polychlorinated Biphenyls><Polychlorobiphenyl Compounds><Predisposition><Prevalence><Prevention approach><Psychiatric Disease><Psychiatric Disorder><Public Health><Receptor Cell><Research Proposals><Resistance><Risk><Risk Factors><Role><Schools><Signal Transduction><Signal Transduction Systems><Signaling><Sleep><Susceptibility><TCDD Receptors><Therapeutic><Toxic Environmental Agents><Toxic Environmental Substances><Translations><U.S. Males><US Men><US male><Woman><adolescence (12-20)><adolescent depression><adolescents with depression><bacteria in the gut><biological signal transduction><blood-brain barrier disruption><bloodbrain barrier><bloodbrain barrier disruption><child depression><childhood depression><childhood onset depression><clinical depression><co-morbid><co-morbidity><comorbidity><depressed adolescents><depression><depression in adolescence><depression symptom><depressive><depressive symptoms><developmental><digestive tract microbiome><drug intervention><drug treatment><economic implication><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><environmental toxicant><epidemiologic><epidemiological><experience><exposed human population><exposure route><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><gastrointestinal microbial flora><gastrointestinal microbiome><genetic vulnerability><genetically predisposed><gut bacteria><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><human exposure><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><juvenile><juvenile human><kids><major depression><major depression disorder><males in America><males in the U.S.><males in the US><males in the USA><males in the United States><manufacturing process><men in America><men in the U.S.><men in the US><men in the USA><men in the United States><mental illness><mouse model><murine model><neural inflammation><neuroinflammation><neuroinflammatory><novel><oncogenic agent><pediatric depression><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pleasure><polychlorobiphenyl><prevent><preventing><psychiatric illness><psychological disorder><resistant><response><social implication><social role><suicidal risk><suicide risk><translation><youngster><youth depression>
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Michal Toborek

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, CORAL GABLES, FL

Good lead · 52/100
Likely hiring
Solid budget
Active award
$499,894
FY 2026

Project Title

Adolescent exposure to PCBs as a risk factor for the development of depression

Grant Number:

5R01ES036983-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/17/2024

End Date:

10/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT This proposal addresses an urgent need to understand and analyze the impact of environmental factors on the development of psychiatric diseases, such as depression. Adolescents are particularly vulnerable to both developing depression and health impacts of environmental exposures. Emerging ...

Research Terms

<0-11 years old><12-20 years old><2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><AH Receptors><Acceleration><Actinobacteria><Actinobacteria class><Actinomycetes><Address><Adolescence><Adolescent><Adolescent Youth><Affect><American male><American man><American men><Appetite><Approaches to prevention><Aryl Hydrocarbon Receptor><BBB disruption><Bacteria><Biota><Blood - brain barrier anatomy><Blood brain barrier dysfunction><Blood-Brain Barrier><Brain><Brain Nervous System><Cancer Causing Agents><Carcinogens><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Child><Child Youth><Children (0-21)><Chronic><Coliform Bacilli><Contamination in food><Data><Data Set><Depressive Syndromes><Depressive disorder><Desire for food><Development><Dioxin Receptors><Disease><Disorder><Drug Therapy><Ecological impact><Emotional Depression><Encephalon><Enteric Bacteria><Enterobacteria><Enterobacteriaceae><Environment><Environmental Exposure><Environmental Factor><Environmental Health><Environmental Health Science><Environmental Impact><Environmental Risk Factor><Environmental Toxin><Epidemiology><Event><Exposure to><Food Contamination><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Goals><Health><Hemato-Encephalic Barrier><High G+C Gram-Positive Bacteria><Human><Individual><Inflammatory Response><Inherited Predisposition><Inherited Susceptibility><Intervention><Intracellular Communication and Signaling><Knowledge><Laboratories><Life Expectancy><Major Depressive Disorder><Medical><Mental Depression><Mental disorders><Mental health disorders><Mice><Mice Mammals><Modern Man><Murine><Mus><Nuclear Translocator><Oncogens><Oral><Outcome><PCBs><Persons><Pharmacological Treatment><Pharmacotherapy><Polyaromatic Hydrocarbon Receptors><Polychlorinated Biphenyls><Polychlorobiphenyl Compounds><Predisposition><Prevalence><Prevention approach><Psychiatric Disease><Psychiatric Disorder><Public Health><Receptor Cell><Research Proposals><Resistance><Risk><Risk Factors><Role><Schools><Signal Transduction><Signal Transduction Systems><Signaling><Sleep><Susceptibility><TCDD Receptors><Therapeutic><Toxic Environmental Agents><Toxic Environmental Substances><Translations><U.S. Males><US Men><US male><Woman><adolescence (12-20)><adolescent depression><adolescents with depression><bacteria in the gut><biological signal transduction><blood-brain barrier disruption><bloodbrain barrier><bloodbrain barrier disruption><child depression><childhood depression><childhood onset depression><clinical depression><co-morbid><co-morbidity><comorbidity><depressed adolescents><depression><depression in adolescence><depression symptom><depressive><depressive symptoms><developmental><digestive tract microbiome><drug intervention><drug treatment><economic implication><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><environmental toxicant><epidemiologic><epidemiological><experience><exposed human population><exposure route><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><gastrointestinal microbial flora><gastrointestinal microbiome><genetic vulnerability><genetically predisposed><gut bacteria><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><human exposure><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><juvenile><juvenile human><kids><major depression><major depression disorder><males in America><males in the U.S.><males in the US><males in the USA><males in the United States><manufacturing process><men in America><men in the U.S.><men in the US><men in the USA><men in the United States><mental illness><mouse model><murine model><neural inflammation><neuroinflammation><neuroinflammatory><novel><oncogenic agent><pediatric depression><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pleasure><polychlorobiphenyl><prevent><preventing><psychiatric illness><psychological disorder><resistant><response><social implication><social role><suicidal risk><suicide risk><translation><youngster><youth depression>
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Mark E Hahn

WOODS HOLE OCEANOGRAPHIC INSTITUTION, WOODS HOLE, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$494,631
FY 2026

Project Title

Understanding the origins and mechanisms of aryl hydrocarbon receptor promiscuity

Grant Number:

5R01ES035261-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/9/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract The aryl hydrocarbon receptor (AHR) is a bHLH-PAS protein that in vertebrate animals is a ligand-activated transcription factor that plays essential roles in the regulation of xenobiotic-metabolizing enzymes and in the mechanisms of toxicity of numerous environmental contami...

Research Terms

<2, 3, 7, 8-Tetrachlorodibenzo-p-dioxin><2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><AH Receptors><Address><Agonist><Allosteric Regulation><Amino Acid Sequence><Amino Acids><Animals><Aromatic Hydrocarbons><Aromatic Polycyclic Hydrocarbons><Aryl Hydrocarbon Receptor><Basal Transcription Factor><Basal transcription factor genes><Basic Research><Basic Science><Binding><Biological Function><Biological Process><Cancers><Causality><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cellular Immune Function><Chemicals><Chordata><Chordates><Circadian Rhythms><DNA mutation><Dependence><Development><Dietary Phytochemical><Dioxin Compound><Dioxin Receptors><Dioxins><Disease><Disorder><Docking><Embryo Development><Embryogenesis><Embryonic Development><Engineering><Environmental Exposure><Environmental Pollutants><Enzyme Gene><Enzymes><Etiology><Eukaryota><Eukaryote><Evolution><Exposure to><Family><Foundations><GI microbiome><General Transcription Factor Gene><General Transcription Factors><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><HTH DNA Binding Domain><HTH Motifs><Helix-Turn-Helix Motifs><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hypoxia Inducible Factor><Immunity><Inflammatory><Intracellular Communication and Signaling><Invertebrata><Invertebrates><L-Tryptophan><Laboratories><Levotryptophan><Ligand Binding><Ligands><Malignant Neoplasms><Malignant Tumor><Mediating><Modernization><Molecular><Molecular Interaction><Molecular Modeling Nucleic Acid Biochemistry><Molecular Modeling Protein/Amino Acid Biochemistry><Molecular Models><Mutate><Mutation><NPAS4><NPAS4 gene><Natural Products><Nuclear Receptors><Nuclear Translocator><Nyctohemeral Rhythm><Organ><Organism-Level Process><Organismal Process><PCBs><Phylogenetic Analysis><Phylogenetics><Physiologic><Physiologic Processes><Physiological><Physiological Processes><Physiology><Play><Polyaromatic Hydrocarbon Receptors><Polychlorinated Biphenyls><Polychlorobiphenyl Compounds><Primary Protein Structure><Process><Property><Proteins><Receptor Protein><Regulation><Research><Role><Sampling><Sensitivity and Specificity><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Statistical Methods><Structure><TCDD><TCDD Receptors><Testing><Tetrachlorodibenzodioxin><Time><Toxic effect><Toxicities><Transcription Activation><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activation><Trees><Tryptophan><Twenty-Four Hour Rhythm><Vertebrate Animals><Vertebrates><Work><Xenobiotics><ahr ligand><aminoacid><anthropogenesis><anthropogenic><aryl hydrocarbon receptor ligand><biological signal transduction><blood cell formation><candidate identification><causation><cellular differentiation><circadian process><circadian rhythmicity><daily biorhythm><developmental><digestive tract microbiome><disease causation><enteric microbiome><environmental contaminant><exposed human population><exposome><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><gastrointestinal microbiome><genome mutation><gut microbiome><gut-associated microbiome><halogenation><helix loop helix><helix turn helix><host microbiome><human exposure><immune function><innovate><innovation><innovative><insight><intestinal biome><intestinal microbiome><malignancy><member><microbial><microbiome><molecular modeling><naturally occurring product><neoplasm/cancer><neuronal PAS domain protein 4><polyaromatic hydrocarbons><polychlorobiphenyl><polynuclear aromatic hydrocarbon><protein sequence><receptor><receptor function><reconstruction><response><sensor><sim gene product><sim protein><single-minded gene product><single-minded protein><social role><statistic methods><transcription factor><vertebrata>
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Zheng Sun

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 52/100
Likely hiring
Solid budget
Active award
$472,448
FY 2026

Project Title

Inter- and transgenerational effects of paternal arsenic exposure

Grant Number:

5R01ES034768-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/8/2023

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT/SUMMARY Industrialization had created widespread pollution, which has been steadily declining in developed countries for decades. It is unclear whether and how long-lasting effects of environmental exposure persist across generations and contribute to chronic diseases in later life. Inorgan...

Research Terms

<Address><Adipose tissue><Affect><Air Pollution><Animal Model><Animal Models and Related Studies><Aquadiol><Arsenic><BS-seq><Bisulfite-based sequencing><Blood><Blood Reticuloendothelial System><Brain><Brain Nervous System><C57BL/6 Mouse><Causality><Cell Communication and Signaling><Cell Signaling><Chemicals><Chronic Disease><Chronic Illness><D-Glucose><DNA Methylation><Developed Countries><Development><Dextrose><Diabetes Mellitus><Dimenformon><Diogyn><Diogynets><Dyslipidemias><ERalpha><ERα><ESR1><ESR1 gene><Eating><Encephalon><Endocrine disruption><Endocrine system><Endocrine/Metabolic Organ System><Energy Expenditure><Energy Metabolism><Environmental Exposure><Enzyme Gene><Enzymes><Epidemic><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Estrace><Estradiol><Estradiol Receptor alpha><Estradiol Receptor α><Estradiol-17 beta><Estradiol-17beta><Estraldine><Estrogen Receptor 1><Estrogen Receptor alpha><Estrogen Receptor α><Estrogen Receptors><Estrogens><Etiology><Exposure to><Fats><Fatty Tissue><Fatty acid glycerol esters><Female><Fertilized Egg><Fertilized Ovum><Food Energy><Food Intake><Free Fatty Acids><Functional RNA><GI microbiome><Gene Expression><Generalized Growth><Generations><Genes><Germ-Free><Glucose><Glucose Intolerance><Gonadal Hormones><Growth><HAZMAT><Hazardous Materials><Hazardous Substances><Hepatic><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Hormonal System><Hypophysis><Hypophysis Cerebri><Hypothalamic structure><Hypothalamus><Industrialization><Industrialized Countries><Industrialized Nations><Intermediary Metabolism><Intracellular Communication and Signaling><KO mice><Knock-out Mice><Knockout Mice><Lead><Length><Lipids><Liver><Liver Cells><Malabsorption Syndromes><Mammalia><Mammals><Masks><Metabolic><Metabolic Processes><Metabolic syndrome><Metabolic/Endocrine Body System><Metabolism><Methylation><Mice><Mice Mammals><Molecular><Murine><Mus><Muscle><Muscle Tissue><NR3A1><Noncoding RNA><Nonesterified Fatty Acids><Nontranslated RNA><Null Mouse><Nutrient><Obesity><Oophorectomy><Ovariectomy><Ovocyclin><Ovocylin><Pb element><Phenotype><Physiology><Pituitary><Pituitary Gland><Pituitary Nervous System><Poison><Pollution><Predisposition><Progynon><Role><Signal Transduction><Signal Transduction Systems><Signaling><Solid><Sperm><Spermatozoa><Susceptibility><Therapeutic Estradiol><Therapeutic Estrogen><Tissue Growth><Toxic Chemical><Toxic Substance><Triacylglycerol><Triglycerides><Untranslated RNA><Urbanization><Water Pollution><adipogenesis><adipose><adiposity><alter microbiome><arsenics><biological signal transduction><bisulfite sequencing><bisulfite-seq><causation><chronic disorder><compare to control><comparison control><corpulence><developed country><developed nation><developed nations><developmental><diabetes><digestive tract microbiome><disease causation><disease registry><drinking water><endocrine disrupting><endocrine gland/system><enteric microbiome><entire genome><environmental chemical><epigenetically><exposed in utero><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fat metabolism><fatty acid oxidation><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><female gonadectomy><fetal exposure><focus on male><focused on men><full genome><gastrointestinal absorption disorder><gastrointestinal microbiome><glucose RA><glucose metabolism><glucose production><glucose rate of appearance><gut microbiome><gut-associated microbiome><haz mat><heavy metal Pb><heavy metal lead><hepatic body system><hepatic organ system><hormonal signals><hormone signals><hypothalamic><in utero exposure><insight><intergenerational><intestinal biome><intestinal malabsorption><intestinal microbiome><intra-uterine environmental exposure><intrauterine environmental exposure><later in life><later life><lipid biosynthesis><lipid metabolism><lipogenesis><malabsorption><male><male focused><male specific><male targeted><metabolic phenotype><metabotype><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><model of animal><mouse model><murine model><muscular><noncoding><nutrient absorption><offspring><ontogeny><pharmacologic><pituitary gonadal axis><prenatal exposure><prenatally exposed><prototype><sex><social role><sperm cell><targeted to men><toxic compound><transcriptomics><wasting><white adipose tissue><whole genome><yellow adipose tissue><younger age><zoosperm><zygote><♀><♂>
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Catherine Elizabeth Oldenburg

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$469,343
FY 2026

Project Title

Azithromycin as adjunctive treatment for uncomplicated severe acute malnutrition: the AMOUR trial

Grant Number:

5R01HD111532-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/8/2023

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Amoxicillin is recommended by the World Health Organization (WHO) as adjunctive therapy for the treatment of uncomplicated severe acute malnutrition (SAM). Because children with uncomplicated SAM may have asymptomatic infection due to immune suppression, presumptive treatmen...

Research Terms

<0-11 years old><1 year of age><1 year old><6 year old><6 years of age><Active Follow-up><Acute><Africa South of the Sahara><Amoxicillin><Amoxicilline><Amoxil><Amoxycillin><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Area><Azadose><Azithromycin><Azitrocin><Azythromycin><Burkina Faso><Burkina Fasso><Campylobacter><Causality><Cessation of life><Child><Child Care><Child Mortality><Child Youth><Children (0-21)><Clinical><Co-Trimoxazole><Communities><Cotrimoxazole><Data><Death><Dose><Enrollment><Equipoise><Etiology><Evaluation><GI microbiome><Genetic><Government><Guidelines><Half-Life><Health Care Facility><Health Facilities><Hydroxyampicillin><Immune system><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Incidence><Individual><Infant><Infection><Malawi><Malnutrition><Miscellaneous Antibiotic><Morbidity><NICHD><National Institute of Child Health and Human Development><Niger><Nutritional><Nutritional Deficiency><Nyasaland><Oral><Out-patients><Outcome><Outpatients><Participant><Persons><Placebos><Policies><Polymox><Population><Primary Health Care><Probability><Protocol><Protocols documentation><Puericulture><Randomization trial><Randomized><Randomized, Controlled Trials><Recommendation><Recovery><Resistance to antibiotics><Resistant to antibiotics><Role><Running><Sampling><Sham Treatment><Sub-Saharan Africa><Subgroup><Subsaharan Africa><Tanzania><Trimox><Ultreon><Undernutrition><Upper Volta><Utimox><Weight><Weight Gain><Weight Increase><World Health Organization><Wymox><Zithromax><Zitromax><active followup><age 1><age 1 year><age 6><age 6 years><aged 1 year><aged one year><antibiotic drug resistance><antibiotic resistant><bacteria pathogen><bacterial disease treatment><bacterial infectious disease treatment><bacterial pathogen><body weight gain><body weight increase><care facilities><causation><death risk><determine efficacy><dietary deficiency><digestive tract microbiome><disease causation><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><enroll><enteric microbiome><evaluate efficacy><evidence base><examine efficacy><follow up><follow-up><followed up><followup><gastrointestinal microbiome><gut dysbiosis><gut microbiome><gut-associated microbiome><hospital re-admission><hospital readmission><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved outcome><infection risk><insight><intestinal biome><intestinal microbiome><kids><malnourished><mortality><mortality risk><nutrition deficiency><nutrition deficiency disorder><nutritional deficiency disorder><nutritious><one year of age><one year old><pathogenic bacteria><peer><population based><prevent><prevent relapse><preventing><programs><randomisation><randomization><randomized control trial><randomized placebo control trial><randomized placebo controlled trial><randomized trial><randomly assigned><re-admission><re-hospitalization><readmission><recruit><rehospitalization><relapse prevention><resistome><routine care><screening><screenings><sham therapy><six year old><six years of age><social role><treatment guidelines><weights><wt gain><youngster>
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Mustafa Ozcam

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 52/100
Likely hiring
Solid budget
Active award
$466,500
FY 2026

Project Title

Gut Microbial Protein Metabolism in Food Allergy and Oral Immunotherapy Efficacy

Grant Number:

1DP2AI192747-01

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract Food allergies are common and life-threatening pediatric conditions, predominantly triggered by specific protein motifs in foods, such as Ara h proteins in peanuts (e.g., Ara h 2). Allergen-specific oral immunotherapy (OIT), in which patients are exposed to increasing doses ...

Research Terms

<0-11 years old><Affect><Alimentary Canal><Allergen Immunotherapy><Allergens><Allergic><Allergic Reaction><Allergic to food><Allergy><Allergy immunotherapy><Allergy to food><Allergy to peanuts><Amino Acid Motifs><Antigenic Determinants><Bacteria><Binding Determinants><Bioreactors><Cell Body><Cells><Child><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Trials><Co-culture><Cocultivation><Coculture><Coculture Techniques><Data><Development><Dietary Proteins><Digestion><Digestive Tract><Disease remission><Dose><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Effectiveness><Encapsulated><Engineered Probiotics><Engineering><Enzyme Gene><Enzymes><Epitopes><Esteroproteases><Exhibits><Exposure to><FDA approved><Failure><Fermentation><Food><Food Allergy><Food Hypersensitivity><GI Tract><GI microbiome><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Copy Number><Gene Dosage><Genes><Gnotobiotic><Gnotobiotics><Groundnut Hypersensitivity><Human><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><IgE><Immune><Immune mediated therapy><Immune system><Immunes><Immunoglobulin E><Immunologically Directed Therapy><Immunotherapeutic agent><Immunotherapy><In Situ><In Vitro><Individual><Individual Differences><Ingestion><Intermediary Metabolism><Investigation><L-Proline><Life><Lower GI Tract><Lower Gastrointestinal Tract><Metabolic Processes><Metabolism><Microbial Genetics><Microbiomics><Modern Man><Modified Probiotics><Molecular><Mucosal Immune System><Multi-Institutional Clinical Trial><Multi-center clinical trial><Multi-site clinical trial><Multicenter clinical trial><Multisite clinical trial><N-terminal><NGS Method><NGS system><NH2-terminal><Oral Administration><Oral Drug Administration><Patients><Peanut Hypersensitivity><Peptidases><Peptide Hydrolases><Peptides><Persons><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phase><Placebo Control><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Powder dose form><Powders><Probiotic Engineering><Production><Proline><Property><Protease Gene><Proteases><Protein Cleavage><Protein Motifs><Proteinases><Proteins><Proteolysis><Proteolytic Enzymes><Proteomics><Randomized><Remission><Remission Induction><Research><Research Associate><Resistance><Role><Sampling><Science of Microbial Genetics><Severities><Small Intestines><Structure><System><Testing><Therapeutic><Training><United States><alimentary tract><allergic reaction to peanut><allergic response to peanut><allergic to peanuts><customized therapy><customized treatment><delivery vector><delivery vehicle><desensitization><determine efficacy><developmental><digestive canal><digestive tract microbiome><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><enteric microbiome><evaluate efficacy><examine efficacy><fecal sample><gastrointestinal microbiome><genome editing><genomic editing><gut microbes><gut microbial species><gut microbiome><gut-associated microbiome><immune drugs><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapeutics><immune-based therapies><immune-based treatments><immuno therapy><immunologic therapeutics><immunotherapeutics><immunotherapy agent><immunotherapy clinical trials><individual response><individualized medicine><individualized patient treatment><individualized response><individualized therapeutic strategy><individualized therapy><individualized treatment><ingest><intestinal biome><intestinal microbes><intestinal microbiome><intraoral drug delivery><kids><lactic acid bacteria><microbial><microbiome><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbioreactor><microorganism><microorganism genetics><mouse model><multiomics><multiple omics><murine model><next gen sequencing><next generation sequencing><nextgen sequencing><novel><oral immunotherapy><panomics><patient response><patient specific response><patient specific therapies><patient specific treatment><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><peanut allergic><peanut allergy><pediatric><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pharmaceutical><placebo controlled><polypeptide><post-doc><post-doctoral><post-doctoral trainee><programs><protein metabolism><randomisation><randomization><randomly assigned><research associates><resistant><responders and non-responders><responders from non-responders><responders or non-responders><responders versus non-responders><responders vs non-responders><responders/nonresponders><response><response to therapy><response to treatment><responsive patient><small bowel><social role><stool sample><stool specimen><tailored medical treatment><tailored therapy><tailored treatment><therapeutic response><therapy response><treatment response><treatment responsiveness><tripeptidyl aminopeptidase><tripeptidyl peptidase><unique treatment><youngster>
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Melanie R Rutkowski

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$447,799
FY 2026

Project Title

Gut microbiome-mediated differences within the pre-malignant mammary tissue environment enhance early breast tumor metastasis

Grant Number:

5R01CA262634-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

A critical unmet medical need is to understand why some patients diagnosed with hormone receptor (HR+, estrogen- and progesterone-receptor positive; Her2 negative) breast cancer experience recurrences with distant metastatic disease whereas others do not, despite similar treatment. This is a signifi...

Research Terms

<Adoptive Transfer><Affect><Autoregulation><Benign><Bile Acids><Biodiversity><Biological Diversity><Blood><Blood Reticuloendothelial System><Body Tissues><Breast><Breast Cancer><Breast Cancer Patient><Breast Neoplasms><Breast Tissue><Breast Tumor Patient><Breast Tumors><CCL2><CCL2 gene><Cell Body><Cell Communication><Cell Degranulation><Cell Interaction><Cell-to-Cell Interaction><Cells><Chemokine, CC Motif, Ligand 2><Clinical><Data><Detection><Diagnosis><Dinoprostone><Disease><Disease Outcome><Disorder><Distal><Distant><Drug Combinations><Drugs><Environment><Estrogen Receptors><Fibroblasts><GI commensal><GI microbiome><Gene Expression><Generalized Growth><Genomics><Goals><Growth><HR positive><Histologic><Histologically><Homeostasis><Hormone Receptor><Immune><Immunes><Immunofluorescence><Immunofluorescence Immunologic><Incidence><Individual><Inflammation><Inflammatory><Insulin Resistance><Intermediary Metabolism><Intervention><Link><Lung><Lung Respiratory System><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphatic nodes><MCAF><MCP-1><MCP1><Macrophage><Malignant Breast Neoplasm><Mammary Cancer><Mammary Gland Parenchyma><Mammary Gland Tissue><Mammary Neoplasms><Marrow Mast Cell><Mediating><Medical><Medication><Metabolic><Metabolic Processes><Metabolism><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Metastatic breast cancer><Mice><Mice Mammals><Modeling><Modification><Molecular><Monocyte Chemoattractant Protein-1><Monocyte Chemotactic Protein-1><Monocyte Chemotactic and Activating Factor><Monocyte Chemotactic and Activating Protein><Monocyte Chemotactive and Activating Factor><Monocyte Secretory Protein JE><Murine><Mus><Mφ><Neoplasm Metastasis><Newly Diagnosed><Normal Tissue><Normal tissue morphology><Outcome><PGE2><PGE2 alpha><PGE2alpha><PR Positive><Pathway interactions><Patients><Pharmaceutical Preparations><Phenotype><Physiological Homeostasis><Predisposition><Prevention><Primary Neoplasm><Primary Tumor><Prostaglandin E2><Prostaglandin E2 alpha><Prostaglandin E2alpha><Recurrence><Recurrent><Relapse><Reporter><Risk><Role><SCYA2><Sampling><Secondary Neoplasm><Secondary Tumor><Signal Pathway><Small Inducible Cytokine A2><Susceptibility><Testing><Therapeutic><Tissue Basophils><Tissue Growth><Tissues><Tumor Cell><Tumor-associated macrophages><Upregulation><Woman><Work><acylcarnitine><cancer metastasis><cancer microenvironment><clinical relevance><clinically relevant><commensal bacteria in the gastrointestinal tract><commensal bacteria in the gut><commensal bacteria in the intestine><cost><digestive tract microbiome><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><enteric commensal><enteric microbiome><epidemiology research study><epidemiology study><epidemiology survey><experience><gastrointestinal commensal><gastrointestinal microbiome><gut commensal><gut microbiome><gut-associated microbiome><high risk><hormone receptor +><hormone receptor-positive><individuals with breast cancer><insulin resistant><insulin tolerance><intestinal biome><intestinal commensal><intestinal microbiome><lymph gland><lymph nodes><lymphnodes><malignant breast tumor><mammary><mammary tumor><mast cell><mastocyte><metastatic breast tumor><metastatic mammary cancer><metastatic mammary tumor><microbial><microbial imbalance><microbiome><mortality><mouse model><murine model><neoplastic cell><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><ontogeny><pathway><patients with breast cancer><person with breast cancer><pharmacologic><precancer><precancerous><premalignant><prevent><preventing><progesterone receptor positive><recruit><repurposing><response><response to therapy><response to treatment><restoration><social role><therapeutic response><therapy response><treatment response><treatment responsiveness><tumor><tumor cell metastasis><tumor diagnosis><tumor growth><tumor initiation><tumor microenvironment>
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NANCY P KELLER

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 52/100
Likely hiring
Solid budget
Active award
$427,625
FY 2026

Project Title

Accessing the hidden biosynthetic capabilities of fungi

Grant Number:

5R35GM156119-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Filamentous fungi are a major source of valuable natural products (e.g. antibacterial penicillin, the immunosuppressant cyclosporin, the cholesterol-lowering drug lovastatin, the fungicide azoxystrobin and the pesticide paraherquamide). Yet despite progress in genomic sequencing and ...

Research Terms

<6-Methylcompactin><Address><Anti-Bacterial Agents><Anticholesteremic Agents><Anticholesteremic Drugs><Anticholesteremics><Area><Bioinformatics><Biological><Bionomics><Chemicals><Chemistry><Cholesterol Inhibitors><Cholesterol-Lowering Drugs><Cholesterol-Lowering agents><Complex><Computational toolkit><Copper><Cu element><Cyclosporines><Cyclosporins><Drugs><Ecology><Filamentous Fungi><Foundations><Fungal natural products><Fungi natural product><Gene Cluster><Genes><Genome><Genomics><Health><Human><Immunosuppressants><Immunosuppressive Agents><Immunosuppressive drug><Immunosuppressive treatment><Investigation><Knowledge><Logic><Lovastatin><Medication><Metals><Methods><Mevinolin><Mining><Modern Man><Molds><Molecular><Monacolin K><Natural Products><Penicillins><Pesticides><Pharmaceutical Preparations><Procedures><Production><Proteins><Role><Route><Source><Structure><Technology><Work><anti-bacterial><anti-cholesterol agents><anti-cholesterol drugs><antihypercholesterolemic agent><biologic><chemical synthesis><computational toolbox><computational tools><computational toolset><computerized tools><drug/agent><fungicidal><fungicide><fungus><immune suppressive agent><immune suppressor><immunosuppressive substance><immunosuppressor><innovate><innovation><innovative><isocyanide><mevacor><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><naturally occurring product><paraherquamide><secondary metabolite><small molecule><social role><tool>
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Steven L. Salzberg

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 52/100
Likely hiring
Solid budget
Active award
$420,660
FY 2026

Project Title

Computational Methods for Microbial and Microbiome Sequence Analysis

Grant Number:

5R35GM130151-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2019

End Date:

1/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract This project will support work on computational methods for microbial and microbiome sequence analysis, including new and improved algorithms for metagenomic classification, genome assembly, and contamination screening. Over the years we have developed multiple systems to so...

Research Terms

<Address><Algorithms><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Area><Bacteria><Blood><Blood Reticuloendothelial System><Brain><Brain Nervous System><Cancers><Cerebrospinal Fluid><Classification><Collaborations><Communities><Complex><Computer software><Computers><Computing Methodologies><ConvNet><Data><Data Bases><Data Science><Databases><Development><Diagnosis><Effectiveness><Encephalon><Environment><Eukaryota><Eukaryote><Eye><Eyeball><Functional Metagenomics><Genes><Genome><Human Microbiome><Infection><Lead><Machine Learning><Malignant Neoplasms><Malignant Tumor><Memory><Metagenomics><Methods><Microbiomics><Organ><Organism><Pathogenicity><Pb element><Problem Solving><Publishing><Reporting><Research><Running><SEQ-AN><Scientist><Sequence Analyses><Sequence Analysis><Software><Source><System><Systematics><Systems Analyses><Systems Analysis><Techniques><Training><Virus><Work><analyze microbiome><cerebral spinal fluid><computational methodology><computational methods><computer based method><computer methods><computing method><convolutional network><convolutional neural nets><convolutional neural network><data base><data quality><developmental><fungus><genome database><genomic data><genomic dataset><heavy metal Pb><heavy metal lead><human disease><human tissue><human-associated microbiome><improved><insight><laptop><living system><machine based learning><malignancy><metagenome sequencing><metagenomic sequencing><microbes genome><microbial><microbial genome><microbiome><microbiome analysis><microbiome research><microbiome science><microbiome studies><microorganism><neoplasm/cancer><public data base><public database><publicly accessible data base><publicly accessible database><publicly available data base><publicly available database><rapid growth><screening><screenings><spinal fluid>
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JOHN Joseph MCCARTHY

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Good lead · 52/100
Likely hiring
Solid budget
Active award
$399,502
FY 2026

Project Title

Using the gut microbiome to treat skeletal muscle atrophy

Grant Number:

5R01AR084282-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY When skeletal muscle is not used on a regular basis it becomes smaller as a result of myofiber atrophy; not surprisingly, this muscle atrophy is accompanied by a loss of strength. Disuse atrophy is most often caused by disease, surgery, injury or aging. Although there is a good understanding...

Research Terms

<Adult females><Adult women><Affect><Aging><Animals><Antibiotic Therapy><Antibiotic Treatment><Area><Atrophic><Atrophy><Attenuated><Bacteria><Cancer Cachexia><Cell Body><Cell Culture Techniques><Cells><Computer Simulation><Computer based Simulation><Contralateral><Data><Development><Disease><Disorder><Disuse Atrophy><Disuse-Induced Bone Loss><Earth><Effectiveness><Environment><Epithelium><Eukaryotic Cell><Evolution><Exercise><Extremities><Female><Females in adulthood><Fiber><Flexor><Food><Formulation><Functional Metagenomics><Future><GI colonization><GI microbiome><Gel><Generalized Growth><Genome><Germ-Free><Goals><Growth><Health><Human><Immobilization><Immunoblotting><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Individual><Injury><Leg><Life><Limb structure><Limbs><Mammalia><Mammals><Measures><Mediating><Metabolic><Metabolic Protein Degradation><Metagenomics><Methods><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Muscle><Muscle Atrophy><Muscle Tissue><Muscle function><Muscular Atrophy><Non-Trunk><Operative Procedures><Operative Surgical Procedures><Persons><Pipecolic Acids><Planet Earth><Probiotics><Production><Protein Biosynthesis><Protein Turnover><RNA Seq><RNA sequencing><RNAseq><Regulation><Regulatory Protein Degradation><Reporting><Research><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Skeletal Muscle><Soleus><Soleus Muscle><Source><Squirrel><Succinates><Surgical><Surgical Interventions><Surgical Procedure><Testing><Tissue Growth><Training><Transplantation><Voluntary Muscle><Western Blotting><Western Immunoblotting><Women in adulthood><Work><attenuate><attenuates><bacteria in the gut><bacterial disease treatment><bacterial infectious disease treatment><bone disuse atrophy><cancer associated cachexia><cancer induced cachexia><cancer-associated muscle wasting><cancer-induced muscle atrophy><cancer-induced muscle loss><cancer-induced muscle wasting><cancer-related cachexia><cell culture><cell cultures><commensal flora><commensal microbes><commensal microbiota><commensal microflora><computational simulation><computerized simulation><developmental><digestive tract microbiome><disuse - associated bone loss><disuse - induced atrophy><disuse osteoporosis><effective therapy><effective treatment><enteric microbiome><exercise training><experiment><experimental research><experimental study><experiments><gastrointestinal microbiome><gastrointestinal tract colonization><gut bacteria><gut colonization><gut microbiome><gut-associated microbiome><in vivo><injuries><intestinal biome><intestinal colonization><intestinal microbiome><male><metabolism measurement><metabolomics><metabonomics><microbial><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle hypertrophy><muscle loss><muscle mass><muscle strength><muscle wasting><muscular><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><orthopedic freezing><preservation><probiotic supplement><probiotic supplementation><protein biomarkers><protein blotting><protein degradation><protein markers><protein synthesis><resistance exercise><resistance training><response><sedentary><skeletal muscle atrophy><skeletal muscle breakdown><skeletal muscle loss><skeletal muscle protein loss><skeletal muscle wasting><supplementation with probiotics><surgery><transcriptome sequencing><transcriptomic sequencing><transplant><true squirrel><tumor-induced cachexia><tumor-induced muscle wasting><♀><♂>
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Paul David Morton

VIRGINIA POLYTECHNIC INST AND ST UNIV, BLACKSBURG, VA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$395,123
FY 2026

Project Title

Evaluation of Pb-induced perturbations in the central and enteric nervous system

Grant Number:

5R01ES035013-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Lead (Pb) is an everyday contaminant with low level exposure rates of one in every three children worldwide. A major source of exposure to this heavy metal is via drinking water delivered through Pb lines. Children are particularly vulnerable, with an exposure rate of up to 800 milli...

Research Terms

<0-11 years old><21+ years old><ASD><Acceleration><Adult><Adult Human><Affect><Alimentary Canal><American><Animal Model><Animal Models and Related Studies><Animals><Assay><Attention><Autism><Autistic Disorder><BBB crossing><Bacteria resistance><Bacteria resistant><Bacterial resistant><Binding><Bioassay><Biological Assay><Blood><Blood - brain barrier anatomy><Blood Circulation><Blood Reticuloendothelial System><Blood-Brain Barrier><Bloodstream><Brachydanio rerio><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><CNS Nervous System><Calcium><Calcium-Binding Proteins><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Chemicals><Child><Child Nutrition><Child Youth><Children (0-21)><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Colitis><Communication><Confocal Microscopy><Congresses><Connector Neuron><Danio rerio><Development><Differences between sexes><Differs between sexes><Digestive Tract><Disease><Disorder><Disturbance in cognition><Dose><Early Infantile Autism><Electron Microscopy><Encephalon><Encephalon Diseases><Enteral><Enteric><Enteric Nervous System><Environmental Exposure><Evaluation><Exocytosis><Exposure to><Exposure to Pb2+><Family suidae><Feces><Funding><GI Tract><GI microbiome><GI microbiota><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><General Population><General Public><Generalized Growth><Genes><Germ-Free><Growth><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><Heavy Metals><Hemato-Encephalic Barrier><High Prevalence><Histology><Human><Hydrogen Oxide><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Immune system><Impaired cognition><In Vitro><Individual><Infant><Infantile Autism><Infrastructure><Ingestion><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intestinal><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><Lead><Lead levels><Link><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mice><Mice Mammals><Michigan><Modeling><Modern Man><Molecular Interaction><Murine><Mus><NMR Imaging><NMR Tomography><Neocortex><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Development><Neuraxis><Neurocyte><Neurodevelopmental Disorder><Neuroendocrine><Neuroendocrine System><Neurologic Disorders><Neurologic outcome><Neurological Development Disorder><Neurological Disorders><Neurological outcome><Neurons><Neurosecretory Systems><Nuclear Magnetic Resonance Imaging><Nutrition Research><Nutritional Study><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Oral><Organ><Paralysis Agitans><Parkinson><Parkinson Disease><Pb contaminated><Pb contamination><Pb element><Pb exposed><Pb exposure><Pb levels><Pb2+ Exposure><Pb2+ contaminated><Pb2+ contamination><Pb2+ exposed><Physiology><Pigs><Play><Policies><Pre-Clinical Model><Preclinical Models><Predisposition><Primary Parkinsonism><Proteins><Reporting><Rodent><Rodentia><Rodents Mammals><Role><Series><Services><Sex Differences><Sexual differences><Signal Transduction><Signal Transduction Systems><Signaling><Source><Suidae><Susceptibility><Swine><System><Techniques><Teratogenic><Teratogenicity><Teratogens><Testing><Therapeutic Intervention><Tissue Growth><Training><Water><Water Intake><Water Supply><Water consumption><Work><Zebra Danio><Zebra Fish><Zebrafish><Zeugmatography><absorption><adulthood><alimentary tract><alter microbiome><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><bacterial resistance><biological signal transduction><blood-brain barrier crossing><bloodbrain barrier><bloodbrain barrier crossing><bowel><cell type><cognitive dysfunction><cognitive loss><contaminated to lead><contamination to lead><developmental><developmental disease><developmental disorder><digestive canal><digestive tract microbiome><drinking water><enteric microbial community><enteric microbiome><enteric microbiota><experience><experiment><experimental research><experimental study><experiments><exposed to lead><exposure to Pb><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><exposure to lead><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><heavy metal Pb><heavy metal lead><homotypical cortex><imaging><impaired brain development><improved><in vivo><ingest><insight><intervention therapy><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><isocortex><kids><lead contaminated><lead contamination><lead exposed><lead exposure><lead level><level of lead><loss of function mutation><microbial><microbial consortia><microbial flora><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><microbiota><microflora><microorganism><model of animal><model organism><multiomics><multiple omics><multispecies consortia><neopallium><nervous system development><neurodevelopment><neurodevelopmental disease><neurological disease><neuronal><neurotoxic><new approaches><novel><novel approaches><novel strategies><novel strategy><ontogeny><panomics><pediatric nutrition><pig model><piglet model><porcine><porcine model><pre-clinical><preclinical><resistance to Bacteria><resistance to Bacterial><resistant to Bacteria><resistant to Bacterial><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><stool><substantia alba><suid><swine model><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><white matter><youngster>
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George A. O'Toole

DARTMOUTH COLLEGE, HANOVER, NH

Good lead · 52/100
Likely hiring
Solid budget
Active award
$387,254
FY 2026

Project Title

Arsenic, the Microbiome & Health Outcomes: Mechanisms to Methods of Intervention

Grant Number:

5R01ES033988-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/7/2022

End Date:

10/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT The gut microbiome is directly impacted by metals exposure and changes in the gut microbiome affect downstream health. An individual’s microbiome also modifies the health effects of toxicants such as arsenic by transforming them into potentially more or less harmful substances. Thus, unders...

Research Terms

<0-11 years old><12 year old><12 years of age><3 year old><3 years of age><3-10C><AMCF-I><Address><Affect><Airway health><Animals><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Arsenic><Back><Bacteroides><CF Preschoolers><CXCL8><Cell Culture Techniques><Cell model><Cellular model><Child><Child Youth><Children (0-21)><Children with CF><Clinical><Clinical Research><Clinical Study><Development><Dorsum><Enrollment><Environmental Epidemiology><Environmental Pollutants><Environmental Toxin><Epidemiological data><Epidemiology><Epidemiology data><Exposure to><Feces><Food><Future><GCP1><GI microbiome><GI microbiota><Gastrointestinal microbiota><Goals><Health><Human><Hydrogen Oxide><IL-8><IL8><IL8 gene><Immune><Immune system><Immunes><Immunity><In Vitro><Individual><Infant><Inflammation><Intervention><Intestinal><Intestines><K60><Laboratories><Life><Link><Lung><Lung Respiratory System><Mediating><Metal exposure><Metals><Methods><Microbe><Microbiomics><Miscellaneous Antibiotic><Modern Man><Molecular><Mothers><NIEHS><National Institute of Environmental Health Sciences><New Hampshire><Organoids><Outcome><Pattern><Pneumonia><Policies><Prevention><Probiotics><Propionates><Regulation><Research Resources><Resources><Respiratory Disease><Respiratory System Disease><Respiratory System Disorder><Risk><Rural Community><Rural Population><Rural group><Rural people><SCYB8><Short-Chain Fatty Acids><TSG-1><Testing><Time><Toxic Environmental Agents><Toxic Environmental Substances><Training><Upper Respiratory Infections><Upper Respiratory Tract Infection><Volatile Fatty Acids><Water><Wheezing><Work><age 12><age 12 years><age 3><age 3 years><alter microbiome><arsenics><b-ENAP><bio-informatics tool><bioinformatics tool><birth cohort study><birth cohort survey><bowel><cell culture><cell cultures><children with cystic fibrosis><cystic fibrosis preschoolers><developmental><dietary><digestive tract microbiome><drinking water><dysbacteriosis><dysbiosis><dysbiotic><early childhood><enroll><enteric microbial community><enteric microbiome><enteric microbiota><environmental contaminant><environmental toxicant><epidemiologic><epidemiologic data><epidemiological><epigenome><epigenomics><exposure to metal><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><insight><intestinal biome><intestinal epithelium><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kids><later in life><later life><lung function><lung health><metabolome><metabonome><microbial imbalance><microbiome><microbiome adaptation><microbiome alteration><microbiome community composition><microbiome composition><microbiome perturbation><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiota composition><mouse model><murine model><novel><pediatric cystic fibrosis><pulmonary function><pulmonary health><respiratory health><risk mitigation><rural individual><sex><stool><three year old><three years of age><toxic metal><toxicant><twelve year old><twelve years of age><wheeze><youngster>
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Huilin Li

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 52/100
Likely hiring
Solid budget
Active award
$381,375
FY 2026

Project Title

Novel Computational Methods for Microbiome Data Analysis in Longitudinal Study

Grant Number:

5R01LM014085-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/5/2023

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

With the steady growth of longitudinal microbiome studies, microbiomes are now on the cusp of clinical utility for several diseases, including obesity, diabetes, inflammatory bowel disease, and cancer. Motivated by the PI’s broad microbiome collaborations at New York University Langone Health and bu...

Research Terms

<Address><Affect><Bioconductor><Bioinformatics><COVID infected patient><COVID patient><COVID positive patient><COVID-19><COVID-19 infected patient><COVID-19 patient><COVID-19 positive patient><COVID19 patient><COVID19 positive patient><CV-19><Cancers><Cardiovascular Diseases><Cessation of life><Characteristics><Clinical><Code><Coding System><Collaborations><Communities><Companions><Complex><Computer software><Computing Methodologies><Coronavirus Infectious Disease 2019><Critical Illness><Critically Ill><Data><Data Analyses><Data Analysis><Death><Diabetes Mellitus><Disease><Disease Progression><Disorder><Ecologic Systems><Ecological Systems><Ecosystem><Environmental Exposure><Functional Metagenomics><Future><Galaxy><Gene variant><General Taxonomy><Generalized Growth><Genes><Genetic><Genetic Diversity><Genetic Models><Genetic Variation><Growth><Health><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Human Characteristics><Human Microbiome><Human Nature><Infant><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Investigators><Link><Longitudinal Studies><Longitudinal Surveys><Malignant Neoplasms><Malignant Tumor><Mechanical ventilation><Mediating><Metagenomics><Methods><Microbe><Microbiomics><Modern Man><Nature><New York><Obesity><Organ><Outcome><Pathway interactions><Performance><Phenotype><Phylogenetic Analysis><Phylogenetics><Population Genetics><Predicting Risk><Probabilistic Models><Probability Models><Process><Property><Research Design><Research Methodology><Research Methods><Research Personnel><Researchers><Risk><Role><SARS-CoV-2 infected patient><SARS-CoV-2 patient><SARS-CoV-2 positive patient><Sampling><Scheme><Software><Source><Statistical Models><Structure><Study Type><System><Systems Analyses><Systems Analysis><Taxonomy><Techniques><Technology><Time><Tissue Growth><Trees><Universities><Variant><Variation><Work><adiposity><airway microbiome><allelic variant><analytical method><analytical tool><analyze microbiome><bacterial community><bio-informatics tool><bioinformatics tool><cardiovascular disorder><cohort><computational methodology><computational methods><computer based method><computer methods><computing method><coronavirus disease 2019><coronavirus disease 2019 infected patient><coronavirus disease 2019 patient><coronavirus disease 2019 positive patient><coronavirus disease infected patient><coronavirus disease patient><coronavirus disease positive patient><coronavirus disease-19><coronavirus disease-19 patient><coronavirus infectious disease-19><coronavirus patient><corpulence><data interpretation><depository><design><designing><develop software><developing computer software><diabetes><disease risk><disorder risk><experience><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><forecasting risk><gene function><genetic variant><genome scale><genome-wide><genomewide><genomic variant><holistic approach><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiome><human-associated microbiota><improved><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><insight><intestinal autoinflammation><long-term study><longitudinal outcome studies><longitudinal research study><malignancy><mechanical respiratory assist><mechanically ventilated><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome analysis><microbiome community><microbiome research><microbiome science><microbiome signature><microbiome studies><multidisciplinary><neoplasm/cancer><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><ontogeny><open source><pathway><patient infected with COVID><patient infected with COVID-19><patient infected with SARS-CoV-2><patient infected with coronavirus disease><patient infected with coronavirus disease 2019><patient infected with severe acute respiratory syndrome coronavirus 2><patient with COVID><patient with COVID-19><patient with COVID19><patient with SARS-CoV-2><patient with coronavirus disease><patient with coronavirus disease 2019><patient with severe acute respiratory distress syndrome coronavirus 2><population based><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><prevent><preventing><repository><research and methods><respiratory microbiome><respiratory tract microbiome><risk prediction><risk predictions><severe acute respiratory syndrome coronavirus 2 infected patient><severe acute respiratory syndrome coronavirus 2 patient><severe acute respiratory syndrome coronavirus 2 positive patient><social role><software development><statistical linear mixed models><statistical linear models><study design><tool><trait><web based interface>
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Feng Tao

TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, COLLEGE STATION, TX

Good lead · 52/100
Likely hiring
Solid budget
Active award
$359,813
FY 2026

Project Title

Short-chain fatty acids and chronic temporomandibular joint pain

Grant Number:

5R01DE031255-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/5/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary: Temporomandibular disorders (TMDs) are the most common temporomandibular joint (TMJ) pain condition; however, the underlying mechanisms remain poorly understood. As such, TMJ pain has long confounded medical and dental health care providers, and current treatment of chronic TMJ pain...

Research Terms

<Acetic Acids><Address><Affect><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Arthralgia><Butanoic Acids><Butyric Acids><Carbohydrates><Cell Communication and Signaling><Cell Signaling><Chronic><Closure by Ligation><Cranial Nerve X><Development><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Face Pain><Facial Pain><Fermentation><Freund's Adjuvant><Freund's Complete Adjuvant><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Transcription><Genes><Genetic Transcription><Germ-Free><Glutamate Carboxy-Lyase><Glutamate Decarboxylase><Glutamic Acid Decarboxylase><Goals><HDAC><HDAC Proteins><Health Care Providers><Health Personnel><Histone Acetylation><Histone Deacetylase><Histone Deacetylation><Inflammatory><Injections><Intracellular Communication and Signaling><Jaw Joint><Joint Pain><KO mice><Knock-out Mice><Knockout Mice><L-Glutamate-1-carboxy-lyase><Ligation><Maintenance><Mandibular joint><Masseter Muscle><Mediating><Medical><Mice><Mice Mammals><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nociception><Nucleus of the Spinal Tract of the Trigeminal Nerve><Null Mouse><Oral health><Pain><Painful><Pathogenesis><Patients><Play><Pneumogastric Nerve><Promoter Regions><Promotor Regions><Property><Propionic Acids><Publishing><RNA Expression><Receptor Protein><Regulation><Research><Resveratrol><Role><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Spinal Trigeminal Nucleus><Structure of trigeminal nerve spinal tract nucleus><System><TMJ><TMJ Diseases><TMJ Disorders><TMJD><Temporomandibular Disorders><Temporomandibular Joint><Temporomandibular Joint Diseases><Temporomandibular Joint Disorders><Temporomandibular Joint and Muscle Disorder><Tendon structure><Tendons><Tenth Cranial Nerve><Testing><Therapeutic Effect><Transcription><Trigeminal System><Vagotomy><Vagus Nerve><Vagus nerve structure><Volatile Fatty Acids><Work><alter microbiome><bacteria in the gut><biological signal transduction><chronic pain><dental health><developmental><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><epigenetic regulation><epigenetically><fatty acid supplementation><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbial flora><gastrointestinal microbiome><gene manipulation><genetic manipulation><genetic promoter element><genetic promoter sequence><genetically manipulate><genetically perturb><gut bacteria><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><health care personnel><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><inhibit pain><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><lower sensory nucleus of trigeminal nerve><medical care providers><medical personnel><microbiome adaptation><microbiome alteration><microbiome perturbation><mouse model><murine model><neuronal><nociceptive><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><pain inhibition><promoter sequence><propanoic acid><receptor><social role><supplementation with fatty acids><treatment provider><trigeminal><vagus nerve stimulation>
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Timothy Robert Sampson

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$346,685
FY 2026

Project Title

Interaction of Pyrethroid Exposure and the Microbiome on Parkinson's Disease related Pathologies

Grant Number:

5R01ES032440-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/9/2022

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Pesticide exposures are a significant risk factor for many neurodegenerative diseases, including Parkinson’s disease (PD). Sporadic PD, with no known etiology accounts for ~90% of disease incidences, as highly penetrant genetic risks are not very prevalent. Experimental models have l...

Research Terms

<Acceleration><Acute><Affect><Ailmentary System><Alimentary Canal><Alimentary System><Animal Model><Animal Models and Related Studies><Architecture><Bacterial Genes><Brain Pathology><CNS Nervous System><Causality><Cell Communication and Signaling><Cell Signaling><Cell Survival><Cell Viability><Central Nervous System><Colon><Constipation><DA Neuron><Data><Degenerative Neurologic Disorders><Digestive System><Digestive Tract><Disease><Disorder><Dopamine neuron><Dysfunction><Engineering / Architecture><Enteric Nervous System><Enteroendocrine Cell><Environment><Environmental Exposure><Environmental Toxin><Epidemiology><Etiology><Exhibits><Experimental Models><Exposure to><Family><Foundations><Functional disorder><GI Tract><GI microbiome><GI microbiota><Gastrointestinal Body System><Gastrointestinal Organ System><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Gene x Environment Interaction><General Taxonomy><Genes><Genetic Risk><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><GxE interaction><Human><Immune><Immunes><Impairment><Incidence><Indigenous><Individual><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Inflammatory Response><Intestinal><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal Motility><Intestinal permeability><Intestines><Intracellular Communication and Signaling><Lactobacillus><Link><Mediating><Mice><Mice Mammals><Microbe><Modern Man><Molecular><Motility><Murine><Mus><NAC precursor><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Neuropeptides><Oral><Organ><Outcome><PARK1 protein><PARK4 protein><Pain><Painful><Paralysis Agitans><Parkinson><Parkinson Disease><Parkinsonian><Parkinsonian Condition><Parkinsonian Diseases><Parkinsonian Disorders><Parkinsonian Syndrome><Parkinsonism><Pathology><Peripheral><Pesticides><Physiologic><Physiological><Physiopathology><Population><Primary Parkinsonism><Primates><Primates Mammals><Production><Resistance><Risk><Risk Factors><Rodent><Rodentia><Rodents Mammals><Role><Rotenone><SNCA><SNCA protein><Severity of illness><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Taxonomy><Testing><Toxic Environmental Agents><Toxic Environmental Substances><Toxicant exposure><Transgenic Mice><Xenobiotic Metabolism><a-syn><a-synuclein><alimentary tract><alpha synuclein><alpha synuclein gene><alphaSP22><alter microbiome><asyn><biological signal transduction><bowel><bowel inflammation><causation><decamethrin><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><deltamethrin><digestive canal><digestive tract microbiome><disease causation><disease diagnosis><disease severity><dopamine system><dopaminergic neuron><dysbacteriosis><dysbiosis><dysbiotic><enteral infection><enteric infection><enteric microbial community><enteric microbiome><enteric microbiota><enteric pathogen infection><enteropathogen infection><enteropathogenic infection><environment effect on gene><environmental toxicant><epidemiologic><epidemiological><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><gastrointestinal><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal system><gene environment interaction><gut community><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><infected with enteropathogen><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><inflammatory modulation><innervation><insight><intestinal autoinflammation><intestinal biome><intestinal flora><intestinal infection><intestinal inflammation><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intestine infection><microbial><microbial imbalance><microbiome><microbiome adaptation><microbiome alteration><microbiome community composition><microbiome components><microbiome composition><microbiome members><microbiome perturbation><microbiome species composition><microbiome structure><model of animal><monoamine><motor disease><motor disorder><motor dysfunction><mouse model><murine model><nerve cell death><nerve cell loss><nerve supply><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><nigrostriatal system><non A-beta component of AD amyloid><non A4 component of amyloid precursor><overexpress><overexpression><pathophysiology><pesticide exposure><pyrethroid><resistant><social role><sporadic Parkinson's Disease><tool><toxic exposure><α synuclein gene><α-syn><α-synuclein>
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Jun Chen

MAYO CLINIC ROCHESTER, ROCHESTER, MN

Good lead · 52/100
Likely hiring
Solid budget
Active award
$327,876
FY 2026

Project Title

Methods for microbiome compositional data

Grant Number:

5R01GM144351-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary The broad and long-term objective of this project concerns the development of novel quantitative methods and biostatistical tools for microbiome data analytics to aid in microbiome-based discovery sciences. The microbiome, also called the second genome of the human, has received much...

Research Terms

<2-dimensional><Accounting><Address><Attention><Biological Markers><Biometrics><Biometry><Biostatistics><Cell Communication and Signaling><Cell Signaling><Characteristics><Charge><Clinic><Collaborations><Communities><Complex><Computer software><Consensus><Data><Data Analyses><Data Analysis><Data Analytics><Data Correlations><Data Set><Development><Disease><Disorder><Experimental Designs><Functional Metagenomics><Genome><Genomics><Goals><Grant><Health><Human><Human Microbiome><Intracellular Communication and Signaling><Investigators><Lead><Linear Models><Manuscripts><Medical><Medicine><Metagenomics><Methodology><Methods><Microbiomics><Modeling><Modern Man><Multiomic Data><Nature><Pb element><Phylogenetic Analysis><Phylogenetics><Phylogeny><Procedures><Prognosis><Proteome><Regression Analyses><Regression Analysis><Regression Diagnostics><Research Design><Research Personnel><Researchers><Role><Sample Size><Sampling><Scheme><Science><Scientific Advances and Accomplishments><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Software><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Statistical Methods><Statistical Regression><Structure><Study Type><Testing><Trees><analytical method><analytical tool><analyze microbiome><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker discovery><customized therapy><customized treatment><data imputation><data interpretation><design><designing><developmental><disease diagnosis><flexibility><flexible><global gene expression><global transcription profile><heavy metal Pb><heavy metal lead><high dimensional data><human-associated microbiome><improved><imputation method><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><inter-individual variability><inter-individual variation><interest><metabolome><metabonome><methylome><microbial><microbiome><microbiome analysis><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><multidimensional data><multidimensional datasets><multiple omic data><novel><open source><patient specific therapies><patient specific treatment><programs><scientific accomplishments><scientific advances><simulation><social role><statistic methods><statistical analysis><statistical analysis core><statistical core><statistics><statistics core><statistics research core><study design><tailored medical treatment><tailored therapy><tailored treatment><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><theories><tool><transcriptome><two-dimensional><unique treatment><user friendly computer software><user friendly software><user-friendly>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Xianyang Zhang

MAYO CLINIC ROCHESTER, ROCHESTER, MN

Good lead · 52/100
Likely hiring
Solid budget
Active award
$327,876
FY 2026

Project Title

Methods for microbiome compositional data

Grant Number:

5R01GM144351-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary The broad and long-term objective of this project concerns the development of novel quantitative methods and biostatistical tools for microbiome data analytics to aid in microbiome-based discovery sciences. The microbiome, also called the second genome of the human, has received much...

Research Terms

<2-dimensional><Accounting><Address><Attention><Biological Markers><Biometrics><Biometry><Biostatistics><Cell Communication and Signaling><Cell Signaling><Characteristics><Charge><Clinic><Collaborations><Communities><Complex><Computer software><Consensus><Data><Data Analyses><Data Analysis><Data Analytics><Data Correlations><Data Set><Development><Disease><Disorder><Experimental Designs><Functional Metagenomics><Genome><Genomics><Goals><Grant><Health><Human><Human Microbiome><Intracellular Communication and Signaling><Investigators><Lead><Linear Models><Manuscripts><Medical><Medicine><Metagenomics><Methodology><Methods><Microbiomics><Modeling><Modern Man><Multiomic Data><Nature><Pb element><Phylogenetic Analysis><Phylogenetics><Phylogeny><Procedures><Prognosis><Proteome><Regression Analyses><Regression Analysis><Regression Diagnostics><Research Design><Research Personnel><Researchers><Role><Sample Size><Sampling><Scheme><Science><Scientific Advances and Accomplishments><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Software><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Statistical Methods><Statistical Regression><Structure><Study Type><Testing><Trees><analytical method><analytical tool><analyze microbiome><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker discovery><customized therapy><customized treatment><data imputation><data interpretation><design><designing><developmental><disease diagnosis><flexibility><flexible><global gene expression><global transcription profile><heavy metal Pb><heavy metal lead><high dimensional data><human-associated microbiome><improved><imputation method><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><inter-individual variability><inter-individual variation><interest><metabolome><metabonome><methylome><microbial><microbiome><microbiome analysis><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><multidimensional data><multidimensional datasets><multiple omic data><novel><open source><patient specific therapies><patient specific treatment><programs><scientific accomplishments><scientific advances><simulation><social role><statistic methods><statistical analysis><statistical analysis core><statistical core><statistics><statistics core><statistics research core><study design><tailored medical treatment><tailored therapy><tailored treatment><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><theories><tool><transcriptome><two-dimensional><unique treatment><user friendly computer software><user friendly software><user-friendly>
View Full Project Details on NIH Reporter
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Shilpa Kodati

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 52/100
Training-friendly
Solid budget
Active award
Career award
$286,534
FY 2026

Project Title

Longitudinal changes in the Gut Microbiota in Non-infectious Uveitis

Grant Number:

5K23EY036928-02

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT To date, the immunological mechanisms that underpin non-infectious uveitis (NIU) are not fully understood. The contribution of the gut microbiota and their metabolites to the development of autoimmune diseases is increasingly being recognized. Recent evidence suggests that alterations in th...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Antigen Mimicry><Antigenic Mimicry><Antimetabolites><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Bioinformatics><Biometrics><Biometry><Biostatistics><Blindness><Butyrates><Cell Body><Cells><Clinical><Clinical Data><Complement><Complement Proteins><Data><Development><Disease><Disorder><Enrollment><Ensure><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Eye><Eyeball><Flare><Frequencies><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Goals><Human><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Immunomodulation><Inflammation><Inflammatory><Institution><Investigators><Laboratories><Lead><Longitudinal Studies><Longitudinal Surveys><Machine Learning><Mentors><Methodology><Michigan><Microbiomics><Modeling><Modern Man><Molecular><Pathway interactions><Patients><Pb element><Peptides><Physicians><Pilot Projects><Prediction of Response to Therapy><Property><Recurrent disease><Relapsed Disease><Reporting><Research><Research Design><Research Personnel><Researchers><Ribosomal RNA><Role><Sampling><Scientist><Short-Chain Fatty Acids><Sight><Structure><Study Type><Therapeutic><Training><Translational Research Enterprise><Treatment Failure><United States><Universities><Uveitis><Vision><Volatile Fatty Acids><Work><alter microbiome><applied learning><autoimmune condition><autoimmune disorder><autoimmune uveitis><autoimmunity disease><biobank><biorepository><career><clinical phenotype><clinical relevance><clinically relevant><comparative><complementation><computer based prediction><developmental><digestive tract microbiome><enroll><enteric microbial community><enteric microbiome><enteric microbiota><epigenetically><fecal metabolome><fecal sample><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hands-on learning><heavy metal Pb><heavy metal lead><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><improved><interactive engagement><interactive learning><intestinal barrier><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal mucosal barrier><intestinal tract microflora><investigate longitudinal><large data sets><large datasets><long-term study><longitudinal investigation><longitudinal outcome studies><longitudinal research><longitudinal research study><machine based learning><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbial><microbial consortia><microbial flora><microbial signature><microbiome><microbiome adaptation><microbiome alteration><microbiome community composition><microbiome composition><microbiome perturbation><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiota><microbiota composition><microflora><mouse model><multispecies consortia><murine model><new drug target><new druggable target><new marker><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel biomarker><novel drug target><novel druggable target><novel marker><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><pathway><patient response><patient specific response><pilot study><precision medicine><precision-based medicine><predict therapeutic response><predict therapy response><predictive modeling><rRNA><response><response to therapy><response to treatment><responsive patient><restoration><skills><social role><stool sample><stool specimen><study design><study longitudinal><survey longitudinal><systemic autoimmune disease><systemic autoimmune disorder><therapeutic response><therapy failure><therapy optimization><therapy prediction><therapy response><translation research enterprise><translational research program><treatment optimization><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><treatment risk><treatment strategy><vision loss><visual function><visual loss>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JAMES R CERHAN

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 48/100
Large award
Active award
Team-scale grant
$4,059,994
FY 2026

Project Title

Human Virome Characterization Center for the Oral-Gut-Brain Axis

Grant Number:

5U54AG089335-02

Activity Code:

U54

Mechanism:

Research Centers

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Overall-Project Summary/Abstract The NIH Human Microbiome Project has redefined our understanding of the human bacteriome, opening new avenues of research in the biomedical and behavioral sciences and improving healthcare delivery. However, the human virome remains largely unexplored. In response to...

Research Terms

<AI system><Acquired brain injury><Age><Area><Arizona><Artificial Intelligence><Behavioral Sciences><Bioinformatics><Biological Specimen Banks><Biological Substance Banks><Biomedical Research><Bionomics><Body System><Brain><Brain Injuries><Brain Nervous System><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 negative><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><COVID19 negative><Cerebrospinal Fluid><Clinic><Clinical><Collaborations><Collection><Communication><Communication Methods><Communities><Computational toolkit><Computer Reasoning><Data><Data Analyses><Data Analysis><Data Analysis and Submission Core><Data Banks><Data Management Resources><Data Management System><Data Science><Databanks><Dental><Deposit><Deposition><Diagnosis><Disease><Disorder><ELSI><Ecology><Emergent Technologies><Emerging Technologies><Encephalon><Ensure><Ethics><Ethnic Origin><Ethnicity><Feces><Florida><Future><Genetic><Genomics><Goals><Health><Human><Human Microbiome><India><Individual><Institution><Investigators><Knowledge><Learning><Life><Long-term cohort><Longitudinal cohort><Machine Intelligence><Machine Learning><Medicine><Mental Depression><Methods><Modern Man><NIDCR><NIDR><NIH><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><National Institutes of Health><Oral><Organ><Organ System><Outcome><Participant><Patient Recruitments><Patients><Physiologic><Physiological><Physiology><Pilot Projects><Policies><Prevalence><Prospective cohort><Publications><Publishing><Race><Races><Research><Research Personnel><Research Specimen><Researchers><Resource Sharing><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 negative><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Saliva><Sampling><Scientific Publication><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shapes><Sight><Specimen><Structure><Swab><Technology><Time><Tissue Banks><Tissue Collection><Tissue repository><Tooth><Tooth structure><United States National Institutes of Health><Update><Viral><Virus><Vision><Work><Zoonoses><Zoonotic><Zoonotic Infection><ages><assess effectiveness><bacterial microbiome><bacteriome><biobank><biological specimen repository><biomed informatics><biomedical informatics><biorepository><biosample repository><biospecimen bank><biospecimen repository><brain damage><brain-injured><cerebral spinal fluid><cohort><college><collegiate><computational toolbox><computational tools><computational toolset><computerized tools><conference><convention><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 negative><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><data access><data deposition><data depository><data harmonization><data interpretation><data repository><data set repository><data sharing><data submission><dataset repository><depository><depression><design><designing><determine effectiveness><effectiveness assessment><effectiveness evaluation><ethical><ethical legal and social><ethical, legal, and social implication><evaluate effectiveness><examine effectiveness><experience><gut to brain axis><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><harmonized data><health and care delivery><health care delivery><health delivery systems><health services delivery><healthspan><healthy life span><human virome><human-associated microbiome><improved><innovate><innovation><innovative><life span><lifespan><machine based learning><microbiome><microbiome sequencing><multiple data types><neural imaging><neuro-imaging><neuroimaging><neurological imaging><novel><operation><operations><participant recruitment><pathogen><pathogenic virus><pilot study><programs><prospective><racial><racial background><racial origin><repository><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 negative><social health determinants><social role><specimen bank><specimen repository><spinal fluid><stool><success><summit><symposia><symposium><synergism><teeth><tool><viral microbiome><viral pathogen><virome><virus pathogen><visual function><web site><website>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Yvonne L Kapila

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 48/100
Large award
Active award
Team-scale grant
$4,059,994
FY 2026

Project Title

Human Virome Characterization Center for the Oral-Gut-Brain Axis

Grant Number:

5U54AG089335-02

Activity Code:

U54

Mechanism:

Research Centers

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Overall-Project Summary/Abstract The NIH Human Microbiome Project has redefined our understanding of the human bacteriome, opening new avenues of research in the biomedical and behavioral sciences and improving healthcare delivery. However, the human virome remains largely unexplored. In response to...

Research Terms

<AI system><Acquired brain injury><Age><Area><Arizona><Artificial Intelligence><Behavioral Sciences><Bioinformatics><Biological Specimen Banks><Biological Substance Banks><Biomedical Research><Bionomics><Body System><Brain><Brain Injuries><Brain Nervous System><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 negative><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><COVID19 negative><Cerebrospinal Fluid><Clinic><Clinical><Collaborations><Collection><Communication><Communication Methods><Communities><Computational toolkit><Computer Reasoning><Data><Data Analyses><Data Analysis><Data Analysis and Submission Core><Data Banks><Data Management Resources><Data Management System><Data Science><Databanks><Dental><Deposit><Deposition><Diagnosis><Disease><Disorder><ELSI><Ecology><Emergent Technologies><Emerging Technologies><Encephalon><Ensure><Ethics><Ethnic Origin><Ethnicity><Feces><Florida><Future><Genetic><Genomics><Goals><Health><Human><Human Microbiome><India><Individual><Institution><Investigators><Knowledge><Learning><Life><Long-term cohort><Longitudinal cohort><Machine Intelligence><Machine Learning><Medicine><Mental Depression><Methods><Modern Man><NIDCR><NIDR><NIH><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><National Institutes of Health><Oral><Organ><Organ System><Outcome><Participant><Patient Recruitments><Patients><Physiologic><Physiological><Physiology><Pilot Projects><Policies><Prevalence><Prospective cohort><Publications><Publishing><Race><Races><Research><Research Personnel><Research Specimen><Researchers><Resource Sharing><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 negative><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Saliva><Sampling><Scientific Publication><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shapes><Sight><Specimen><Structure><Swab><Technology><Time><Tissue Banks><Tissue Collection><Tissue repository><Tooth><Tooth structure><United States National Institutes of Health><Update><Viral><Virus><Vision><Work><Zoonoses><Zoonotic><Zoonotic Infection><ages><assess effectiveness><bacterial microbiome><bacteriome><biobank><biological specimen repository><biomed informatics><biomedical informatics><biorepository><biosample repository><biospecimen bank><biospecimen repository><brain damage><brain-injured><cerebral spinal fluid><cohort><college><collegiate><computational toolbox><computational tools><computational toolset><computerized tools><conference><convention><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 negative><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><data access><data deposition><data depository><data harmonization><data interpretation><data repository><data set repository><data sharing><data submission><dataset repository><depository><depression><design><designing><determine effectiveness><effectiveness assessment><effectiveness evaluation><ethical><ethical legal and social><ethical, legal, and social implication><evaluate effectiveness><examine effectiveness><experience><gut to brain axis><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><harmonized data><health and care delivery><health care delivery><health delivery systems><health services delivery><healthspan><healthy life span><human virome><human-associated microbiome><improved><innovate><innovation><innovative><life span><lifespan><machine based learning><microbiome><microbiome sequencing><multiple data types><neural imaging><neuro-imaging><neuroimaging><neurological imaging><novel><operation><operations><participant recruitment><pathogen><pathogenic virus><pilot study><programs><prospective><racial><racial background><racial origin><repository><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 negative><social health determinants><social role><specimen bank><specimen repository><spinal fluid><stool><success><summit><symposia><symposium><synergism><teeth><tool><viral microbiome><viral pathogen><virome><virus pathogen><visual function><web site><website>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JANICE S LEE

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 48/100
Large award
Active award
Team-scale grant
$4,059,994
FY 2026

Project Title

Human Virome Characterization Center for the Oral-Gut-Brain Axis

Grant Number:

5U54AG089335-02

Activity Code:

U54

Mechanism:

Research Centers

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Overall-Project Summary/Abstract The NIH Human Microbiome Project has redefined our understanding of the human bacteriome, opening new avenues of research in the biomedical and behavioral sciences and improving healthcare delivery. However, the human virome remains largely unexplored. In response to...

Research Terms

<AI system><Acquired brain injury><Age><Area><Arizona><Artificial Intelligence><Behavioral Sciences><Bioinformatics><Biological Specimen Banks><Biological Substance Banks><Biomedical Research><Bionomics><Body System><Brain><Brain Injuries><Brain Nervous System><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 negative><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><COVID19 negative><Cerebrospinal Fluid><Clinic><Clinical><Collaborations><Collection><Communication><Communication Methods><Communities><Computational toolkit><Computer Reasoning><Data><Data Analyses><Data Analysis><Data Analysis and Submission Core><Data Banks><Data Management Resources><Data Management System><Data Science><Databanks><Dental><Deposit><Deposition><Diagnosis><Disease><Disorder><ELSI><Ecology><Emergent Technologies><Emerging Technologies><Encephalon><Ensure><Ethics><Ethnic Origin><Ethnicity><Feces><Florida><Future><Genetic><Genomics><Goals><Health><Human><Human Microbiome><India><Individual><Institution><Investigators><Knowledge><Learning><Life><Long-term cohort><Longitudinal cohort><Machine Intelligence><Machine Learning><Medicine><Mental Depression><Methods><Modern Man><NIDCR><NIDR><NIH><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><National Institutes of Health><Oral><Organ><Organ System><Outcome><Participant><Patient Recruitments><Patients><Physiologic><Physiological><Physiology><Pilot Projects><Policies><Prevalence><Prospective cohort><Publications><Publishing><Race><Races><Research><Research Personnel><Research Specimen><Researchers><Resource Sharing><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 negative><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Saliva><Sampling><Scientific Publication><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shapes><Sight><Specimen><Structure><Swab><Technology><Time><Tissue Banks><Tissue Collection><Tissue repository><Tooth><Tooth structure><United States National Institutes of Health><Update><Viral><Virus><Vision><Work><Zoonoses><Zoonotic><Zoonotic Infection><ages><assess effectiveness><bacterial microbiome><bacteriome><biobank><biological specimen repository><biomed informatics><biomedical informatics><biorepository><biosample repository><biospecimen bank><biospecimen repository><brain damage><brain-injured><cerebral spinal fluid><cohort><college><collegiate><computational toolbox><computational tools><computational toolset><computerized tools><conference><convention><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 negative><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><data access><data deposition><data depository><data harmonization><data interpretation><data repository><data set repository><data sharing><data submission><dataset repository><depository><depression><design><designing><determine effectiveness><effectiveness assessment><effectiveness evaluation><ethical><ethical legal and social><ethical, legal, and social implication><evaluate effectiveness><examine effectiveness><experience><gut to brain axis><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><harmonized data><health and care delivery><health care delivery><health delivery systems><health services delivery><healthspan><healthy life span><human virome><human-associated microbiome><improved><innovate><innovation><innovative><life span><lifespan><machine based learning><microbiome><microbiome sequencing><multiple data types><neural imaging><neuro-imaging><neuroimaging><neurological imaging><novel><operation><operations><participant recruitment><pathogen><pathogenic virus><pilot study><programs><prospective><racial><racial background><racial origin><repository><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 negative><social health determinants><social role><specimen bank><specimen repository><spinal fluid><stool><success><summit><symposia><symposium><synergism><teeth><tool><viral microbiome><viral pathogen><virome><virus pathogen><visual function><web site><website>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Clara M Lajonchere

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 48/100
Large award
Active award
Team-scale grant
$4,059,994
FY 2026

Project Title

Human Virome Characterization Center for the Oral-Gut-Brain Axis

Grant Number:

5U54AG089335-02

Activity Code:

U54

Mechanism:

Research Centers

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Overall-Project Summary/Abstract The NIH Human Microbiome Project has redefined our understanding of the human bacteriome, opening new avenues of research in the biomedical and behavioral sciences and improving healthcare delivery. However, the human virome remains largely unexplored. In response to...

Research Terms

<AI system><Acquired brain injury><Age><Area><Arizona><Artificial Intelligence><Behavioral Sciences><Bioinformatics><Biological Specimen Banks><Biological Substance Banks><Biomedical Research><Bionomics><Body System><Brain><Brain Injuries><Brain Nervous System><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 negative><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><COVID19 negative><Cerebrospinal Fluid><Clinic><Clinical><Collaborations><Collection><Communication><Communication Methods><Communities><Computational toolkit><Computer Reasoning><Data><Data Analyses><Data Analysis><Data Analysis and Submission Core><Data Banks><Data Management Resources><Data Management System><Data Science><Databanks><Dental><Deposit><Deposition><Diagnosis><Disease><Disorder><ELSI><Ecology><Emergent Technologies><Emerging Technologies><Encephalon><Ensure><Ethics><Ethnic Origin><Ethnicity><Feces><Florida><Future><Genetic><Genomics><Goals><Health><Human><Human Microbiome><India><Individual><Institution><Investigators><Knowledge><Learning><Life><Long-term cohort><Longitudinal cohort><Machine Intelligence><Machine Learning><Medicine><Mental Depression><Methods><Modern Man><NIDCR><NIDR><NIH><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><National Institutes of Health><Oral><Organ><Organ System><Outcome><Participant><Patient Recruitments><Patients><Physiologic><Physiological><Physiology><Pilot Projects><Policies><Prevalence><Prospective cohort><Publications><Publishing><Race><Races><Research><Research Personnel><Research Specimen><Researchers><Resource Sharing><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 negative><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Saliva><Sampling><Scientific Publication><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shapes><Sight><Specimen><Structure><Swab><Technology><Time><Tissue Banks><Tissue Collection><Tissue repository><Tooth><Tooth structure><United States National Institutes of Health><Update><Viral><Virus><Vision><Work><Zoonoses><Zoonotic><Zoonotic Infection><ages><assess effectiveness><bacterial microbiome><bacteriome><biobank><biological specimen repository><biomed informatics><biomedical informatics><biorepository><biosample repository><biospecimen bank><biospecimen repository><brain damage><brain-injured><cerebral spinal fluid><cohort><college><collegiate><computational toolbox><computational tools><computational toolset><computerized tools><conference><convention><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 negative><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><data access><data deposition><data depository><data harmonization><data interpretation><data repository><data set repository><data sharing><data submission><dataset repository><depository><depression><design><designing><determine effectiveness><effectiveness assessment><effectiveness evaluation><ethical><ethical legal and social><ethical, legal, and social implication><evaluate effectiveness><examine effectiveness><experience><gut to brain axis><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><harmonized data><health and care delivery><health care delivery><health delivery systems><health services delivery><healthspan><healthy life span><human virome><human-associated microbiome><improved><innovate><innovation><innovative><life span><lifespan><machine based learning><microbiome><microbiome sequencing><multiple data types><neural imaging><neuro-imaging><neuroimaging><neurological imaging><novel><operation><operations><participant recruitment><pathogen><pathogenic virus><pilot study><programs><prospective><racial><racial background><racial origin><repository><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 negative><social health determinants><social role><specimen bank><specimen repository><spinal fluid><stool><success><summit><symposia><symposium><synergism><teeth><tool><viral microbiome><viral pathogen><virome><virus pathogen><visual function><web site><website>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Joseph Frank Petrosino

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 48/100
Large award
Active award
Team-scale grant
$4,059,994
FY 2026

Project Title

Human Virome Characterization Center for the Oral-Gut-Brain Axis

Grant Number:

5U54AG089335-02

Activity Code:

U54

Mechanism:

Research Centers

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Overall-Project Summary/Abstract The NIH Human Microbiome Project has redefined our understanding of the human bacteriome, opening new avenues of research in the biomedical and behavioral sciences and improving healthcare delivery. However, the human virome remains largely unexplored. In response to...

Research Terms

<AI system><Acquired brain injury><Age><Area><Arizona><Artificial Intelligence><Behavioral Sciences><Bioinformatics><Biological Specimen Banks><Biological Substance Banks><Biomedical Research><Bionomics><Body System><Brain><Brain Injuries><Brain Nervous System><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 negative><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><COVID19 negative><Cerebrospinal Fluid><Clinic><Clinical><Collaborations><Collection><Communication><Communication Methods><Communities><Computational toolkit><Computer Reasoning><Data><Data Analyses><Data Analysis><Data Analysis and Submission Core><Data Banks><Data Management Resources><Data Management System><Data Science><Databanks><Dental><Deposit><Deposition><Diagnosis><Disease><Disorder><ELSI><Ecology><Emergent Technologies><Emerging Technologies><Encephalon><Ensure><Ethics><Ethnic Origin><Ethnicity><Feces><Florida><Future><Genetic><Genomics><Goals><Health><Human><Human Microbiome><India><Individual><Institution><Investigators><Knowledge><Learning><Life><Long-term cohort><Longitudinal cohort><Machine Intelligence><Machine Learning><Medicine><Mental Depression><Methods><Modern Man><NIDCR><NIDR><NIH><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><National Institutes of Health><Oral><Organ><Organ System><Outcome><Participant><Patient Recruitments><Patients><Physiologic><Physiological><Physiology><Pilot Projects><Policies><Prevalence><Prospective cohort><Publications><Publishing><Race><Races><Research><Research Personnel><Research Specimen><Researchers><Resource Sharing><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 negative><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Saliva><Sampling><Scientific Publication><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shapes><Sight><Specimen><Structure><Swab><Technology><Time><Tissue Banks><Tissue Collection><Tissue repository><Tooth><Tooth structure><United States National Institutes of Health><Update><Viral><Virus><Vision><Work><Zoonoses><Zoonotic><Zoonotic Infection><ages><assess effectiveness><bacterial microbiome><bacteriome><biobank><biological specimen repository><biomed informatics><biomedical informatics><biorepository><biosample repository><biospecimen bank><biospecimen repository><brain damage><brain-injured><cerebral spinal fluid><cohort><college><collegiate><computational toolbox><computational tools><computational toolset><computerized tools><conference><convention><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 negative><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><data access><data deposition><data depository><data harmonization><data interpretation><data repository><data set repository><data sharing><data submission><dataset repository><depository><depression><design><designing><determine effectiveness><effectiveness assessment><effectiveness evaluation><ethical><ethical legal and social><ethical, legal, and social implication><evaluate effectiveness><examine effectiveness><experience><gut to brain axis><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><harmonized data><health and care delivery><health care delivery><health delivery systems><health services delivery><healthspan><healthy life span><human virome><human-associated microbiome><improved><innovate><innovation><innovative><life span><lifespan><machine based learning><microbiome><microbiome sequencing><multiple data types><neural imaging><neuro-imaging><neuroimaging><neurological imaging><novel><operation><operations><participant recruitment><pathogen><pathogenic virus><pilot study><programs><prospective><racial><racial background><racial origin><repository><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 negative><social health determinants><social role><specimen bank><specimen repository><spinal fluid><stool><success><summit><symposia><symposium><synergism><teeth><tool><viral microbiome><viral pathogen><virome><virus pathogen><visual function><web site><website>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jack Anthony Gilbert

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 48/100
Large award
Active award
Team-scale grant
$3,314,158
FY 2026

Project Title

The UCSD Microbiome and Metagenomics Center

Grant Number:

5U24DK131617-05

Activity Code:

U24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/23/2021

End Date:

11/30/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary The University of California San Diego (UCSD) Microbiome and Metagenomics Center (MMC) as part of the Nutrition for Precision Health (NPH) consortium will provide rapid, robust stool sample processing, high-quality metagenomic and metatranscriptomic data generation, and best-in-class...

Research Terms

<AI system><Acceleration><Address><Agreement><Algorithms><American><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Area><Artificial Intelligence><Bacteria><Benchmarking><Best Practice Analysis><Bioinformatics><Biological Markers><California><Collaborations><Collection><Communication><Communities><Community Outreach><Computer Reasoning><Computer software><Consensus><Core Facility><Cost efficiency><DNA><Data><Data Analyses><Data Analysis><Data Provenance><Dedications><Democracy><Deoxyribonucleic Acid><Detection><Development><Earth><Elements><Ensure><Eukaryota><Eukaryote><Faculty><Feces><Feedback><Fellowship><Functional Metagenomics><General Taxonomy><Generations><Goals><Health><History><Human><Infrastructure><Institution><International><Investments><Laboratory Research><Leadership><Libraries><Machine Intelligence><Metagenomics><Microbe><Microbiomics><Mission><Modern Man><NIDDK><NIH><National Institute of Diabetes and Digestive and Kidney Diseases><National Institutes of Health><Non-Polyadenylated RNA><Nutrition><Nutrition Research><Nutritional Study><Participant><Persons><Pilot Projects><Planet Earth><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Precision Health><Preparation><Procedures><Process><Production><Protocol><Protocols documentation><QOL><Quality Control><Quality of life><RNA><RNA Gene Products><Recording of previous events><Reproducibility><Research><Research Associate><Research Design><Research Support><Resolution><Ribonucleic Acid><Sampling><Scientific Advances and Accomplishments><Scientist><Services><Software><Study Type><Supercomputing><System><Taxonomy><Technology><Time><United States National Institutes of Health><Universities><Virus><Visualization><analyze microbiome><benchmark><beta diversity><bio-informatics infrastructure><bio-markers><biobank><bioinformatics infrastructure><biologic marker><biomarker><biorepository><cost><cost efficient><data access><data analysis core><data analysis research core><data analytics core><data analytics research core><data format><data interpretation><data management><data sharing><data visualization><density><detection sensitivity><developmental><experience><fecal sample><histories><improved><innovate><innovation><innovative><innovative technologies><interest><laptop><metagenome><metaproteomics><metatranscriptomics><microbial><microbiome><microbiome analysis><microbiome research><microbiome science><microbiome studies><multidisciplinary><open source><operation><operations><pilot study><post-doc><post-doctoral><post-doctoral trainee><precision nutrition><preparations><recruit><research associates><resolutions><sample collection><scientific accomplishments><scientific advances><specimen collection><statistics><stool><stool sample><stool specimen><study design><success><super computing><super high resolution><superresolution><synthetic DNA><synthetic construct><tool><ultra high resolution><undergrad><undergraduate><undergraduate student>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

ROB KNIGHT

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 48/100
Large award
Active award
Team-scale grant
$3,314,158
FY 2026

Project Title

The UCSD Microbiome and Metagenomics Center

Grant Number:

5U24DK131617-05

Activity Code:

U24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/23/2021

End Date:

11/30/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary The University of California San Diego (UCSD) Microbiome and Metagenomics Center (MMC) as part of the Nutrition for Precision Health (NPH) consortium will provide rapid, robust stool sample processing, high-quality metagenomic and metatranscriptomic data generation, and best-in-class...

Research Terms

<AI system><Acceleration><Address><Agreement><Algorithms><American><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Area><Artificial Intelligence><Bacteria><Benchmarking><Best Practice Analysis><Bioinformatics><Biological Markers><California><Collaborations><Collection><Communication><Communities><Community Outreach><Computer Reasoning><Computer software><Consensus><Core Facility><Cost efficiency><DNA><Data><Data Analyses><Data Analysis><Data Provenance><Dedications><Democracy><Deoxyribonucleic Acid><Detection><Development><Earth><Elements><Ensure><Eukaryota><Eukaryote><Faculty><Feces><Feedback><Fellowship><Functional Metagenomics><General Taxonomy><Generations><Goals><Health><History><Human><Infrastructure><Institution><International><Investments><Laboratory Research><Leadership><Libraries><Machine Intelligence><Metagenomics><Microbe><Microbiomics><Mission><Modern Man><NIDDK><NIH><National Institute of Diabetes and Digestive and Kidney Diseases><National Institutes of Health><Non-Polyadenylated RNA><Nutrition><Nutrition Research><Nutritional Study><Participant><Persons><Pilot Projects><Planet Earth><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Precision Health><Preparation><Procedures><Process><Production><Protocol><Protocols documentation><QOL><Quality Control><Quality of life><RNA><RNA Gene Products><Recording of previous events><Reproducibility><Research><Research Associate><Research Design><Research Support><Resolution><Ribonucleic Acid><Sampling><Scientific Advances and Accomplishments><Scientist><Services><Software><Study Type><Supercomputing><System><Taxonomy><Technology><Time><United States National Institutes of Health><Universities><Virus><Visualization><analyze microbiome><benchmark><beta diversity><bio-informatics infrastructure><bio-markers><biobank><bioinformatics infrastructure><biologic marker><biomarker><biorepository><cost><cost efficient><data access><data analysis core><data analysis research core><data analytics core><data analytics research core><data format><data interpretation><data management><data sharing><data visualization><density><detection sensitivity><developmental><experience><fecal sample><histories><improved><innovate><innovation><innovative><innovative technologies><interest><laptop><metagenome><metaproteomics><metatranscriptomics><microbial><microbiome><microbiome analysis><microbiome research><microbiome science><microbiome studies><multidisciplinary><open source><operation><operations><pilot study><post-doc><post-doctoral><post-doctoral trainee><precision nutrition><preparations><recruit><research associates><resolutions><sample collection><scientific accomplishments><scientific advances><specimen collection><statistics><stool><stool sample><stool specimen><study design><success><super computing><super high resolution><superresolution><synthetic DNA><synthetic construct><tool><ultra high resolution><undergrad><undergraduate><undergraduate student>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Rhonda S Oates

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 48/100
Above-average budget
Recent
Active award
Team-scale grant
$904,759
FY 2026

Project Title

Production of Pedigreed SPF Rhesus Macaques

Grant Number:

5U42OD010990-26

Activity Code:

U42

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/30/2000

End Date:

1/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Overall Abstract The CNPRC has maintained a pedigreed colony of Indian-origin rhesus macaques for over 22 years. The SPF Pedigreed Indian origin rhesus colony includes both an SPF level 1 colony negative for Simian Retrovirus (SRV), Simian Immmunodeficiency Virus (SIV), Simian T Cell Lymphotrophic V...

Research Terms

<21+ years old><AIDS Virus><AIDS focused research><AIDS related research><AIDS research><AIDS science><AIDS specific research><AIDS/HIV><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adult><Adult Human><American trypanosome><Animals><Assay><Bioassay><Biological Assay><Breeding><CMV><COVID surveillance><COVID-19 surveillance><COVID19 surveillance><California><Censuses><Collection><Cytomegalovirus><Data><Data Analyses><Data Analysis><Development><Diagnostic><Diagnostic tests><GI microbiome><Genetic><Genetic Services><Geography><Goals><HCMV><HIV><HIV Infections><HIV focused research><HIV investigation><HIV related research><HIV research><HIV science><HIV specific research><HIV viral infection><HIV virus infection><HIV-1 infection><HIV/AIDS><Haplotypes><Histocompatibility Complex><Histocompatibility Complices><History><Human Immunodeficiency Viruses><Immune response><Immune system><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Inflammation><Investigation on HIV><Investigators><Knowledge><LAV-HTLV-III><Laboratories><Light><Lymphadenopathy-Associated Virus><Lymphoid Cell><M mulatta><M tuberculosis infection><M. mulatta><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Macaca mulatta><Macaca rhesus><Maintenance><Major Histocompatibility Complex><Major Histocompatibility Complices><Modeling><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Parasitic infection><Pedigree><Peripheral Blood Lymphocyte><Photoradiation><Population><Population Genetics><Primates><Primates Mammals><Production><R-Series Research Projects><R01 Mechanism><R01 Program><Recording of previous events><Reproducibility><Research><Research Design><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Rhadinovirus><Rhesus><Rhesus Macaque><Rhesus Monkey><Rhesus macaque colony><SARS-CoV-2 surveillance><SIV><Salivary Gland Viruses><Sampling><Simian Foamy Virus><Simian Immunodeficiency Viruses><Simian Retroviruses><Study Type><T cruzi><T. cruzi><TB infection><Testing><Trypanosoma cruzi><Tuberculosis><Viral><Virus><Virus-HIV><Wisconsin><Work><adulthood><animal resource><biobank><biorepository><coronavirus disease 2019 surveillance><coronavirus disease surveillance><cytomegalovirus group><data interpretation><detection test><detection tests><developmental><diagnostic assay><digestive tract microbiome><disseminated TB><disseminated tuberculosis><enteric microbiome><fecal microbiome><flexibility><flexible><gastrointestinal><gastrointestinal microbiome><gene testing><gene-based testing><genetic analysis><genetic pedigree><genetic testing><gut microbiome><gut-associated microbiome><histories><host microbiome><host response><human immunodeficiency virus infection><human immunodeficiency virus research><immune system response><immunoresponse><improved><infected with HIV><infected with human immunodeficiency virus><infected with parasites><infection due to Mycobacterium tuberculosis><instrument><intestinal biome><intestinal microbiome><new diagnostics><next generation diagnostics><novel><novel diagnostics><parasite infection><pathogen><pedigree structure><peripheral blood><pilot test><programs><research addressing HIV><research in HIV><research into HIV><research on HIV><research on human immunodeficiency virus><research to address HIV><respiratory><rhesus breeding colony><rhesus colony><rhesus macaque breeding colony><rhesus monkey breeding colony><rhesus monkey colony><science on HIV><science to address HIV><screening><screenings><severe acute respiratory syndrome coronavirus 2 surveillance><simian T cell lymphotrophic virus><stool microbiome><stool-associated microbiome><studies on HIV><study design><testing services><tuberculosis infection><tuberculous spondyloarthropathy><virology>
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Jeffrey A Roberts

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 48/100
Above-average budget
Recent
Active award
Team-scale grant
$904,759
FY 2026

Project Title

Production of Pedigreed SPF Rhesus Macaques

Grant Number:

5U42OD010990-26

Activity Code:

U42

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/30/2000

End Date:

1/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Overall Abstract The CNPRC has maintained a pedigreed colony of Indian-origin rhesus macaques for over 22 years. The SPF Pedigreed Indian origin rhesus colony includes both an SPF level 1 colony negative for Simian Retrovirus (SRV), Simian Immmunodeficiency Virus (SIV), Simian T Cell Lymphotrophic V...

Research Terms

<21+ years old><AIDS Virus><AIDS focused research><AIDS related research><AIDS research><AIDS science><AIDS specific research><AIDS/HIV><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adult><Adult Human><American trypanosome><Animals><Assay><Bioassay><Biological Assay><Breeding><CMV><COVID surveillance><COVID-19 surveillance><COVID19 surveillance><California><Censuses><Collection><Cytomegalovirus><Data><Data Analyses><Data Analysis><Development><Diagnostic><Diagnostic tests><GI microbiome><Genetic><Genetic Services><Geography><Goals><HCMV><HIV><HIV Infections><HIV focused research><HIV investigation><HIV related research><HIV research><HIV science><HIV specific research><HIV viral infection><HIV virus infection><HIV-1 infection><HIV/AIDS><Haplotypes><Histocompatibility Complex><Histocompatibility Complices><History><Human Immunodeficiency Viruses><Immune response><Immune system><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Inflammation><Investigation on HIV><Investigators><Knowledge><LAV-HTLV-III><Laboratories><Light><Lymphadenopathy-Associated Virus><Lymphoid Cell><M mulatta><M tuberculosis infection><M. mulatta><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Macaca mulatta><Macaca rhesus><Maintenance><Major Histocompatibility Complex><Major Histocompatibility Complices><Modeling><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Parasitic infection><Pedigree><Peripheral Blood Lymphocyte><Photoradiation><Population><Population Genetics><Primates><Primates Mammals><Production><R-Series Research Projects><R01 Mechanism><R01 Program><Recording of previous events><Reproducibility><Research><Research Design><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Rhadinovirus><Rhesus><Rhesus Macaque><Rhesus Monkey><Rhesus macaque colony><SARS-CoV-2 surveillance><SIV><Salivary Gland Viruses><Sampling><Simian Foamy Virus><Simian Immunodeficiency Viruses><Simian Retroviruses><Study Type><T cruzi><T. cruzi><TB infection><Testing><Trypanosoma cruzi><Tuberculosis><Viral><Virus><Virus-HIV><Wisconsin><Work><adulthood><animal resource><biobank><biorepository><coronavirus disease 2019 surveillance><coronavirus disease surveillance><cytomegalovirus group><data interpretation><detection test><detection tests><developmental><diagnostic assay><digestive tract microbiome><disseminated TB><disseminated tuberculosis><enteric microbiome><fecal microbiome><flexibility><flexible><gastrointestinal><gastrointestinal microbiome><gene testing><gene-based testing><genetic analysis><genetic pedigree><genetic testing><gut microbiome><gut-associated microbiome><histories><host microbiome><host response><human immunodeficiency virus infection><human immunodeficiency virus research><immune system response><immunoresponse><improved><infected with HIV><infected with human immunodeficiency virus><infected with parasites><infection due to Mycobacterium tuberculosis><instrument><intestinal biome><intestinal microbiome><new diagnostics><next generation diagnostics><novel><novel diagnostics><parasite infection><pathogen><pedigree structure><peripheral blood><pilot test><programs><research addressing HIV><research in HIV><research into HIV><research on HIV><research on human immunodeficiency virus><research to address HIV><respiratory><rhesus breeding colony><rhesus colony><rhesus macaque breeding colony><rhesus monkey breeding colony><rhesus monkey colony><science on HIV><science to address HIV><screening><screenings><severe acute respiratory syndrome coronavirus 2 surveillance><simian T cell lymphotrophic virus><stool microbiome><stool-associated microbiome><studies on HIV><study design><testing services><tuberculosis infection><tuberculous spondyloarthropathy><virology>
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Rachel E Diner

UNIVERSITY OF MEMPHIS, MEMPHIS, TN

Good lead · 48/100
Above-average budget
Very recent
Active award
$506,270
FY 2026

Project Title

Microbiome modulation of environmental contaminant concentrations in shellfish

Grant Number:

1R15ES038670-01

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/17/2026

End Date:

4/16/2029

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Oysters are an important global seafood resource that provide nutrition, economic value, and ecosystem services for coastal communities. However, oysters also bioaccumulate environmental contaminants, including polycyclic aromatic hydrocarbons (PAHs) and human microbial pathogens suc...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Address><Affect><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Aquaculture><Aromatic Polycyclic Hydrocarbons><Assay><Attention><Bacteria><Beneckea><Bioassay><Biologic Factor><Biological><Biological Assay><Biological Factors><Biomedical Research><Body Tissues><Chemicals><Clinical><Communities><Consumption><Development><Ecologic Systems><Ecological Systems><Economics><Ecosystem><Environment><Environmental Factor><Environmental Health><Environmental Health Science><Environmental Pollutants><Environmental Risk Factor><Exhibits><Exposure to><Food><Food Safety><Harvest><Health><Human><Impairment><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Knowledge><Link><Listonella><Mediating><Microbe><Miscellaneous Antibiotic><Mission><Modern Man><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><Nutrition><Nutritional><Organism><Oysters><Pathogenicity><Physiologic><Physiological><Public Health><Recreation><Research><Research Personnel><Research Resources><Researchers><Resources><Risk><Role><Safety><Sea-Food><Seafood><Services><Shapes><Shellfish><Stress><Students><Study models><Testing><Tissues><Training><United States><United States National Institutes of Health><V parahaemolyticus><V parahemolyticus><V vulnificus><V. parahaemolyticus><V. parahemolyticus><V. vulnificus><Vibrio><Vibrio parahaemolyticus><Vibrio parahemolyticus><Vibrio vulnificus><alter microbiome><bacteria pathogen><bacterial pathogen><bioaccumulation><biologic><biomedical scientist><carcinogenicity><developmental><economic><economic value><environmental contaminant><environmental risk><exposed human population><food protection><food supply protection><food-born illness><food-borne disease><food-borne illness><foodborn illness><foodborne disease><foodborne illness><host-associated microbes><host-associated microbial communities><host-associated microbiota><host-associated microorganisms><human exposure><improved><insight><living system><marine culture><microbe pathogen><microbial><microbial pathogen><microbiome><microbiome adaptation><microbiome alteration><microbiome community composition><microbiome composition><microbiome perturbation><microbiome species composition><microbiome structure><monetary value><next generation><novel><nutritious><outcome prediction><pathogen><pathogenic bacteria><pathogenic microbe><phenanthrene><pollutant><polyaromatic hydrocarbons><polynuclear aromatic hydrocarbon><programs><social role><training opportunity><undergrad><undergraduate><undergraduate student><uptake>
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Bernard Fongang

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$220,967
FY 2026

Project Title

Delineating the role of the gut microbiota and its derived metabolites in the development of dementia in multi-ethnic populations

Grant Number:

5K01NS126489-04

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Abstract. Alzheimer's disease (AD) and AD-related dementias (AD/ADRD), with a worldwide prevalence of 50 million in 2018, will surpass cancer as the leading cause of death by 2040. However, efforts to prevent, cure, or even treat AD/ADRD have been unsuccessful. Genetic, blood, and MRI biomarkers ca...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><AD therapy><AD treatment><ADRD><Acceleration><Address><Affect><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's therapy><Alzheimers Dementia><Amentia><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Applications Grants><Award><Bacteria><Bacteroides><Benign senescent forgetfulness><Biochemistry><Bioinformatics><Biological Chemistry><Biology><Blood><Blood - brain barrier anatomy><Blood Plasma><Blood Reticuloendothelial System><Blood-Brain Barrier><Brain><Brain Nervous System><CNS Nervous System><Cancers><Caring><Causality><Cause of Death><Cell Communication and Signaling><Cell Signaling><Central Nervous System><Chronology><Collaborations><Communication><Data><Degenerative Neurologic Disorders><Dementia><Dependence><Development><Diagnosis><Diet><Differences between sexes><Differs between sexes><Disease><Disorder><Drugs><Dysfunction><Encephalon><Episodic memory><Escherichia><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Etiology><Foundations><Framingham Heart Study><Functional disorder><Funding><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genetic><Goals><Grant Proposals><Groups at risk><Hemato-Encephalic Barrier><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Human Microbiome><Individual><Inflammatory><Infrastructure><Intermediary Metabolism><Intracellular Communication and Signaling><K01 Award><K01 Mechanism><K01 Program><Learning><Link><Longitudinal Studies><Longitudinal Surveys><MR Imaging><MR Tomography><MRI><MRI biomarker><MRI marker><MRIs><Magnetic Resonance Imaging><Malignant Neoplasms><Malignant Tumor><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Math Models><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Memory><Mentored Research Scientist Development Award><Mentored Training Award><Mentors><Metabolic><Metabolic Processes><Metabolism><Methods><Microvascular Dysfunction><Modeling><NMR Imaging><NMR Tomography><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neurocognitive><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuropsychologies><Neuropsychology><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Nuclear Magnetic Resonance Imaging><Nutrient><Obesity><Outcome Measure><Pathogenicity><Pathology><People at risk><Persons at risk><Pharmaceutical Preparations><Physiology><Physiopathology><Plasma><Plasma Serum><Population><Population Research><Population-based research><Population-level research><Populations at Risk><Prevalence><Prevotella><Primary Senile Degenerative Dementia><Reporting><Research><Research Scientist Development Award><Reticuloendothelial System, Serum, Plasma><Risk Factors><Role><Sex Differences><Sexual differences><Shigella><Signal Transduction><Signal Transduction Systems><Signaling><South Texas><Structure><Testing><Texas><Therapeutic><Thinking><Time><Zeugmatography><adiposity><age associated cognitive impairment><age associated memory decline><age associated memory deficit><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related memory dysfunction><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><aging related cognitive decline><alzheimer risk><bacteria metabolism><bacterial community><bacterial metabolism><biological signal transduction><bloodbrain barrier><brain atrophy><brain health><career><causation><cerebral atrophy><cohort><community microbes><corpulence><cortical atrophy><declining cognitive functions with aging><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diets><digestive tract microbiome><disease causation><drug development><drug/agent><endophenotype><enteric microbial community><enteric microbiome><enteric microbiota><ethnic difference><ethnic subgroup><ethnicity difference><ethnicity group><ethnoracial minority><executive control><executive function><experience><fecal microbial community><fecal microbiota><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><high risk><human-associated microbiome><innovate><innovation><innovative><insight><interest><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><investigate population><lipidomics><long-term study><longitudinal outcome studies><longitudinal research study><magnetic resonance imaging biomarker><magnetic resonance imaging marker><malignancy><malleable risk><mathematic model><mathematical model><mathematical modeling><measurable outcome><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbiome><microbiota><microbiota derived metabolites><microbiota metabolites><microbiota-gut-brain axis><microbiota-gut-brain interactions><microbiota-gut-brain signaling><microflora><microorganism community><microvascular complications><microvascular disease><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><minority patient><modifiable risk><multi-ethnic><multiethnic><multispecies consortia><neoplasm/cancer><neural imaging><neuro-imaging><neurodegenerative illness><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological imaging><neuropsychologic><new approaches><new drug target><new druggable target><new marker><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel approaches><novel biomarker><novel drug target><novel druggable target><novel marker><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><outcome measurement><pathophysiology><patients from minority><patients of minority><polymicrobial community><population investigation><population level investigation><population specific research><population stratification><prevent><preventing><primary degenerative dementia><processing speed><public health relevance><response><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><risk stratification><senile dementia of the Alzheimer type><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><small vessel disease><social role><stratify risk><structural biology><studies of populations><study of the population><study population><substantia alba><survey population><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><thoughts><visual memory><white matter>
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Laurel Elizabeth Redding

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$178,886
FY 2026

Project Title

Impact of pet contact on antimicrobial-associated dysbiosis and Clostridioides difficile infection

Grant Number:

5K23AI163351-05

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/9/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Clostridioides difficile infection (CDI) is one of the most common causes of healthcare-associated infectious diarrhea and results in significant morbidity and mortality. CDI occurs when the native gut microbiome is disrupted, most often following antimicrobial therapy, and the cons...

Research Terms

<Age Years><Animals><Asthma><Atopic Allergy><Bioinformatics><Bionomics><Bronchial Asthma><C diff><C difficile><C. diff><C. difficile><C. difficile colitis><Cessation of life><Characteristics><Clinical><Clostridioides difficile><Clostridioides difficile colitis><Clostridium difficile><Clostridium difficile colitis><Communities><Data><Death><Dedications><Dental Implants><Development><Development Plans><Diarrhea><Disease><Disorder><Ecology><Elderly><Environment><Epidemiology><Foundations><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Health><Health Care><Human Microbiome><Indigenous><Infection><Infectious Disease Epidemiology><Infectious Epidemiology><Intervention><Investigators><Long-term cohort study><Longitudinal cohort study><Mentors><Metabolic><Methods><Microbiology><Microbiomics><Morbidity><Outcome><Ownership><Patients><Pennsylvania><Persons><Physical activity><Proliferating><Pseudomembranous Colitis><Recovery><Recurrence><Recurrent><Research><Research Personnel><Research Proposals><Researchers><Risk><Sampling><Source><Testing><Therapeutic><Therapeutic Intervention><Training><University resources><advanced age><anti-microbial><antimicrobial><atopic triad><atopy><bacteria pathogen><bacterial pathogen><career><career development><colonization resistance><deep sequencing><developmental><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><elderly patient><enteric microbial community><enteric microbiome><enteric microbiota><epidemiologic><epidemiological><experience><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><functional restoration><gastrointestinal microbial flora><gastrointestinal microbiome><geriatric><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><human-associated microbiome><improved><intervention therapy><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><microbial><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome intervention><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><mortality><multispecies consortia><novel><older patient><pathogen><pathogenic bacteria><patient oriented research><patient oriented study><pet animal><pets><prevent><preventing><prophylactic><prospective><protective effect><restoration><restore function><restore functionality><restore lost function><senior citizen><statistics><stress reduction><success><user-friendly>
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Sasha Zheng Prisco

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$175,068
FY 2026

Project Title

Modulating the Microbiome to Enhance Right Ventricular Function in Pulmonary Arterial Hypertension

Grant Number:

5K08HL168166-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/8/2023

End Date:

11/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary The goals of this proposal are to help Sasha Prisco, MD, PhD, a cardiovascular physician-scientist, transition to independence and to further the understanding of mechanisms of right ventricular dysfunction in pulmonary arterial hypertension. Pulmonary arterial hypertension is a prog...

Research Terms

<Address><Adverse effects><Affect><Attenuated><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Bacterial Translocation><Blood Serum><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac infarction><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Matrix><Cessation of life><Common Rat Strains><Cytokine Activation><Cytokine Receptors><Cytoskeletal System><Cytoskeleton><Data><Death><Depressed mood><Development><Disease><Disorder><Doctor of Philosophy><Down-Regulation><Drug Therapy><Echocardiogram><Echocardiography><Exercise Test><Family><Fibrosis><Functional Metagenomics><Funding><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Goals><Goblet Cells><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><Heart Muscle Cells><Heart Vascular><Heart myocyte><Histologic><Histologically><Hypertrophy><Hypoxia><Hypoxic><Immune><Immune Cell Activation><Immunes><Immunofluorescence><Immunofluorescence Immunologic><Inflammation><Intermittent fasting><Intestinal><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Intracellular Communication and Signaling><Intraventricular Pressure><Knowledge><Lactobacillus><Left Ventricular Dysfunction><Length><Macrophage><Measures><Mediating><Mentors><Metagenomics><Micro-tubule><Microtubules><Modeling><Molecular><Monocrotaline><Morphology><Mucins><Mucus Glycoprotein><Myocardial Infarct><Myocardial Infarction><Mφ><Oxygen Deficiency><Pathologic><Ph.D.><PhD><Pharmacological Treatment><Pharmacotherapy><Physicians><Physiologic intraventricular pressure><Physiology><Preclinical data><Proliferating><Proteins><Proteomics><Pulmonary Hypertension><Rat><Rats Mammals><Rattus><Receptor Activation><Research><Right Ventricles><Right Ventricular Dysfunction><Right Ventricular Function><Right heart dysfunction><Right ventricle dysfunction><Right ventricular structure><Right-sided heart dysfunction><Rodent Model><Scientist><Serum><Serum Proteins><Signal Transduction><Signal Transduction Systems><Signaling><Structure><Supplementation><T-Cells><T-Lymphocyte><Techniques><Testing><Time><Training><Translational Research><Translational Science><Transthoracic Echocardiography><Vascular Diseases><Vascular Disorder><Ventricular><Ventricular Pressure><Villus><analyze microbiome><attenuate><attenuates><beta Tubulin><biological signal transduction><blood vessel disorder><bowel><cardiac infarct><cardiomyocyte><career><circulatory system><clinical relevance><clinically relevant><coronary attack><coronary infarct><coronary infarction><cytokine><depressed><design><designing><developmental><dietary><digestive tract microbiome><drug intervention><drug treatment><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><gastrointestinal microbial flora><gastrointestinal microbiome><glycoprotein 130><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heart attack><heart infarct><heart infarction><heart sonography><hemodynamics><immune activation><improved><in vivo><intestinal barrier><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal mucosal barrier><intestinal tract microflora><intestinal villi><intracellular skeleton><jejunum><junctophilin><junctophilin-1><junctophilin-2><junctophilin-3><left ventricle abnormality><microbiome><microbiome analysis><mortality><multiomics><multiple omics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><panomics><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pre-clinical><preclinical><preclinical findings><preclinical information><prevent><preventing><pulmonary><pulmonary arterial hypertension><pulmonary artery hypertension><right heart failure><right sided heart failure><right ventricle failure><right ventricular failure><right ventricular heart failure><sadness><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><survival prediction><systemic inflammation><systemic inflammatory response><thymus derived lymphocyte><translation research><translational investigation><treadmill><vascular dysfunction><vasculopathy><α Tubulin><β-Tubulin>
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Theodora Katerina Karagounis

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$172,005
FY 2026

Project Title

Contributions of gastrointestinal Staphylococcus aureus and other gut microbiota to pediatric atopic dermatitis

Grant Number:

5K08AR084045-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Atopic dermatitis (AD) is the most common inflammatory skin disease in children worldwide and has a substantial detrimental impact on patients’ quality of life. Staphylococcus aureus is known to contribute to AD pathogenesis and is also found at high rates in the gut of infants. Howe...

Research Terms

<0-11 years old><16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><21+ years old><Accounting><Adult><Adult Human><Affect><Age><Alimentary Canal><Alleles><Allelomorphs><Atopic Dermatitis><Atopic Eczema><Atopic Neurodermatitis><Attention><Biology><Child><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Trials><Collection><Comparative Genomic Analysis><Core Facility><Cutaneous><Cutaneous Disorder><Cytokine Gene><DNA mutation><Data><Dermatoses><Digestive Tract><Disease><Disease remission><Disorder><Disseminated Neurodermatitis><Environment><Evaluation><Faculty><Failure><Feces><Flare><GI Tract><GI colonization><GI microbiome><GI microbiota><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Gene Expression><Genetic Change><Genetic defect><Genetic mutation><Genome><Genomics><Germ><Germ-Free><Health><Histologic><Histologically><Individual><Infant><Inflammation><Inflammatory><Intestinal><Intestines><Investigators><Measures><Mediating><Mentors><Mice><Mice Mammals><Microbe><Microbiology><Molecular Epidemiology><Morbidity><Murine><Mus><Mutation><Pathogenesis><Patients><Physicians><Population><Position><Positioning Attribute><Probability><QOL><Quality of life><Rectum><Regulator Genes><Remission><Research><Research Personnel><Research Training><Researchers><Role><S aureus><S. aureus><Sampling><Scientist><Severities><Site><Skin><Skin Diseases><Skin Diseases and Manifestations><Skin colonization><Source><Staph aureus><Staphylococcus aureus><Swab><Techniques><Testing><Therapeutic><Therapeutic Intervention><Training><Transcriptional Regulatory Elements><Transmission><Variant><Variation><Virulence><Work><adulthood><ages><alimentary tract><allergic dermatitis><allergic eczema><analyze microbiome><bowel><burden of disease><burden of illness><child patients><clinical phenotype><clinical relevance><clinically relevant><cohort><cutaneous disease><cutaneous microbiome><density><dermal disease><dermal disorder><dermal microbiome><digestive canal><digestive tract microbiome><disease burden><enteric microbial community><enteric microbiome><enteric microbiota><epidermal microbiome><fecal sample><fitness><gastrointestinal><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><genetic trans acting element><genome mutation><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><high risk><human subject><improved><in vivo Model><intervention therapy><intestinal biome><intestinal colonization><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><kids><microbial consortia><microbial flora><microbiome><microbiome analysis><microbiota><microflora><mouse model><multispecies consortia><murine model><mutant><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><pediatric><pediatric patients><pressure><rectal microbiota><regulatory gene><sample collection><skin biome><skin disorder><skin microbiome><social role><specimen collection><stool><stool sample><stool specimen><therapeutic target><trans acting element><translational genetics><transmission process><youngster>
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Nicole Beaulieu Perez

NEW YORK UNIVERSITY, NEW YORK, NY

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$168,480
FY 2026

Project Title

Reducing Disparities in Mental and Metabolic Health among Predominantly Low-Income, Black and Hispanic Women with and without HIV

Grant Number:

5K08MD019998-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/21/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT In the United States, Black and Hispanic women (BHW) have the greatest risks of poverty, type 2 diabetes (T2D), and depression, problems which represent overlapping and mutually reinforcing epidemics. In the context of HIV, the economic, metabolic, and mental health risks are even greater, ...

Research Terms

<AIDS Virus><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adult-Onset Diabetes Mellitus><Affect><Aging><Anti-HIV Positivity><Behavioral><Bioinformatics><Biological><Biological Markers><Biology><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Causality><Clinical><Clinical Data><Cohort Studies><Collection><Communities><Critical Paths><Critical Pathways><Cross-Sectional Studies><Cross-Sectional Survey><Data><Data Collection><Decrease disparity><Development><Diagnosis><Disease Frequency Surveys><Disproportionate number of females><Disproportionate number of women><Disproportionately affects females><Disproportionately affects women><Disproportionately impacts females><Disproportionately impacts women><Disproportionately in females><Disproportionately in women><Ecological impact><Economically Deprived><Economics><Emotional Depression><Environmental Factor><Environmental Impact><Environmental Risk Factor><Epidemic><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Ethnic Origin><Ethnicity><Etiology><Exposure to><Functional MRI><Functional Magnetic Resonance Imaging><Funding><Future><GI microbiome><Glycohemoglobin A><Glycosylated hemoglobin A><Goals><Grant><HIV><HIV Positive><HIV Positivity><HIV Seroconversion><HIV Seropositivity><HIV antibody positive><HIV disease status><HIV infection status><HIV serostatus><HIV status><HIV+><HIV1 infection status><HIV1 status><HTLV-III Seroconversion><HTLV-III Seropositivity><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Hemoglobin A(1)><Heterogeneity><Hispanic Females><Hispanic Women><Human Immunodeficiency Viruses><Impoverished><Individual><K-Awards><K-Series Research Career Programs><Ketosis-Resistant Diabetes Mellitus><LAV-HTLV-III><Link><Low income><Lower disparity><Lymphadenopathy-Associated Virus><Maps><Maturity-Onset Diabetes Mellitus><Mental Depression><Mental Health><Mental Hygiene><Mentors><Metabolic><Metabolic dysfunction><Methods><Molecular><NCMHD><NIDDM><NIH><NIMH><NIMHD><National Center on Minority Health and Health Disparities><National Institute of Mental Health><National Institute of Minority Health and Health Disparities><National Institute on Minority Health and Health Disparities><National Institutes of Health><Neurobiology><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nutrition><Outcome><Pathway interactions><Poverty><Psyche structure><Psychological Health><Race><Races><Research><Research Career Program><Risk><Risk Factors><Role><Sentinel><Severities><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Stress><Symptoms><T2 DM><T2D><T2DM><The Multi-center AIDS Cohort Study><The Multicenter AIDS Cohort Study><Training><Translating><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><United States National Institutes of Health><Variant><Variation><Virus-HIV><Woman><Women's Interagency HIV Study><Women's cohort><Work><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><adult onset diabetes><aging induced epigenetic change><aging-associated epigenetic change><aging-related epigenetic change><alter microbiome><bio-markers><biologic><biologic marker><biomarker><black female><black women><brain based><built environment><causation><co-morbid><co-morbidity><cohort><cohort in women><cohort on women><cohort research study><cohort survey><comorbidity><cross-sectional research study><depression><depression symptom><depressive><depressive symptoms><design><designing><developmental><diagnostic biomarker><diagnostic marker><digestive tract microbiome><disease causation><disparity in health><disparity reduction><early life stress><economic><economic disparity><economically disadvantaged><enteric microbiome><environmental risk><epigenetic aging><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic regulation of aging><epigenetically><experience><fMRI><faster epigenetic aging><faster rates of epigenetic aging><female bias><female cohort><female predominance><female preponderance><food insecure><food insecurity><food scarcity><gastrointestinal microbiome><gut microbes><gut microbial species><gut microbiome><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><health disparity><hemoglobin A1c><improved><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><indexing><inflammation marker><inflammatory marker><intestinal biome><intestinal microbes><intestinal microbiome><ketosis resistant diabetes><low SES><low food security><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><maturity onset diabetes><mental><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><mitigate disparity><multimorbidity><multiomics><multiple chronic conditions><multiple omics><neural imaging><neuro-imaging><neurobiological><neuroimaging><neurological imaging><panomics><pathway><predominance in females><predominance in women><programs><protective factors><racial><racial background><racial origin><rapid epigenetic aging><reduce disparity><reduction in disparity><social><social culture><social disadvantage><social disparities><social factors><social inequality><social role><social stress><socially stressed><socio-cultural><socio-economic><socio-economically><sociocultural><socioeconomically><socioeconomics><type 2 DM><type II DM><type two diabetes><women's predominance><women's preponderance>
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Sean Paul Spencer

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$165,996
FY 2026

Project Title

Defining Small Intestinal Microbial Landscapes To Improve Therapeutics For Gastrointestinal Disease

Grant Number:

5K08DK134856-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/3/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary: Defining Small Intestinal Microbial Landscapes To Improve Therapeutics For Gastrointestinal Disease Disease Relevance: Irritable Bowel Syndrome (IBS) is a chronic disorder characterized by altered bowel function (consistency and/or frequency) in additional to abdominal pain, effecti...

Research Terms

<Abdominal Pain><Alimentary Canal><Antigens><Award><Bacteria><Bile Acids><Biology><Bionomics><Capsules><Carbohydrates><Characteristics><Chronic Disease><Chronic Illness><Clinical Data><Clinical Research><Clinical Study><Communities><Complement 2><Data><Deglutition><Development><Development Plans><Devices><Diagnosis><Dietary intake><Digestive Tract><Disease><Disorder><Distal><Ecologic Systems><Ecological Systems><Ecology><Ecosystem><Ensure><Environment><Feces><Frequencies><Functional Metagenomics><GI Tract><GI microbiota><Gastroenterology><Gastrointestinal Diseases><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><Health Care Costs><Health Costs><Human><Human Microbiome><Immune><Immune system><Immunes><Immunity><Immunologic Stimulation><Immunological Stimulation><Immunology><Immunostimulation><In Vitro><Inflammatory><Institution><Intestinal><Intestines><Investigators><Irritable Bowel Syndrome><Irritable Colon><Leadership><Libraries><Maps><Medicine><Mentors><Mentorship><Metagenomics><Methods><Mice><Mice Mammals><Microbe><Microbiomics><Modern Man><Molecular Genetics><Mucous Colitis><Murine><Mus><Outcome><Patients><Phenotype><Phylogenetic Analysis><Phylogenetics><Physicians><Physiology><Population><Preclinical Testing><Property><Research><Research Personnel><Research Resources><Research Training><Researchers><Resolution><Resources><Ribosomal RNA><Role><Sampling><Sampling Studies><Science><Scientist><Severities><Site><Small Intestines><Swallowing><Symptoms><Technology><Testing><Therapeutic><Training><Universities><Work><alimentary tract><bacterial community><bile acid metabolism><bile metabolism><bowel><capsule><career><career development><chronic disorder><clinical training><colon microbes><colon microbial community><colon microbiota><colonic microbiota><depository><developmental><dietary><digestive canal><dysbacteriosis><dysbiosis><dysbiotic><effective therapy><effective treatment><enteric microbial community><enteric microbiota><entire genome><experience><fecal sample><full genome><gastrointestinal disorder><gastrointestinal microbial flora><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><host microbe association><host microbe relationship><host microbiota><host microflora><host-microbe interactions><host-microbial interactions><host-microorganism interactions><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiome><human-associated microbiota><immunogen><improved><intestinal flora><intestinal microbiota><intestinal microflora><intestinal tract microflora><knowledge base><metabolism measurement><metabolomics><metabonomics><microbial><microbial consortia><microbial flora><microbial imbalance><microbiome research><microbiome science><microbiome studies><microbiota><microbiota composition><microflora><mouse model><multispecies consortia><murine model><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pre-clinical testing><programs><rRNA><repository><resident microbes><resident microflora><resolutions><sample collection><skill acquisition><skill development><skills><small bowel><social role><spastic colon><specimen collection><stool><stool sample><stool specimen><success><tool><whole genome>
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Caitlin Walfoort Elgarten

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$164,052
FY 2026

Project Title

Understanding longitudinal microbiome change in relation to immunologic outcomes in pediatric SCT recipients.

Grant Number:

5K23HL161309-05

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT This Mentored Patient-Oriented Research Career Development Award proposal will provide didactic and experiential training, expert mentorship, and an exceptional research environment to facilitate Dr. Caitlin Elgarten's development as an independent clinician scientist. Dr. E...

Research Terms

<0-11 years old><Acute GVHD><Acute Graft Versus Host Disease><Address><Advisory Committees><Alimentary Canal><Allogenic><Anti-Infective Agents><Anti-Infective Drugs><Anti-Infectives><Anti-infective Preparation><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Behavior><Bioinformatics><Biological Markers><Biology><Blood Diseases><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood leukocyte><Carbapenems><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Child><Child Youth><Childhood><Childhood Leukemia><Children (0-21)><Children's Hospital><Children's Oncology Group><Clinical><Clinical Research><Clinical Study><Complex><Concentration measurement><Data><Development><Digestive Tract><Disease><Disorder><Drug Kinetics><Drug Targeting><Drugs><Engraftment><Ensure><Environment><Epidemiologist><Epidemiology><Event><Exposure to><Foundations><Functional Metagenomics><Future><GI Tract><Gastrointestinal Tract><Gastrointestinal tract structure><Goals><GvHD><Health Care><Hematologic Body System><Hematologic Diseases><Hematologic Organ System><Hematological Disease><Hematological Disorder><Hematopoietic Body System><Hematopoietic System><Hemoglobinopathies><High-dimensional Modeling><Homologous Wasting Disease><Human><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune system><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Diseases><Immunological><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunologically><Immunologics><Individual><Infection><Intervention><Intervention Studies><Intracellular Communication and Signaling><Investigation><Investigators><K23 Award><K23 Mechanism><K23 Program><Kinetics><Knowledge><Leukocytes><Leukocytes Reticuloendothelial System><Life><Link><Long-term cohort><Longitudinal cohort><Lymphocytopenia><Lymphopenia><Marrow Neutrophil><Marrow leukocyte><Measurement><Measures><Mediating><Medication><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentorship><Metagenomics><Methods><Microbiomics><Miscellaneous Antibiotic><Modeling><Modern Man><Nature><Neutropenia><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Outcome><Pathogenesis><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pediatric Hospitals><Pediatric Leukemia><Pediatric Oncologist><Pediatric Oncology Group><Pediatric cohort><Pennsylvania><Peripheral><Pharmaceutical Epidemiology><Pharmaceutical Preparations><Pharmacoepidemiology><Pharmacokinetics><Philadelphia><Physicians><Physiologic><Physiological><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Progenitor Cell Transplantation><Progenitor Cells><Prospective cohort><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><Recovery><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Residual><Residual state><Resources><Risk><Runt Disease><Sampling><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Statistical Methods><Stem Cell Transplantation><Stem cell transplant><Subcellular Process><Supportive Therapy><Supportive care><System><Systems Development><Task Forces><Therapeutic><Time><Training><Transplant Recipients><Transplantation and Immune System><Universities><Validation><White Blood Cells><White Cell><Work><acute graft vs host disease><acute graft vs. host disease><adverse consequence><adverse outcome><advisory team><alimentary tract><analyze microbiome><analyzing longitudinal><behavior study><behavioral study><bio-markers><biologic marker><biological signal transduction><biomarker><blood disorder><bone marrow failure syndrome><career><children with leukemia><clinical relevance><clinical significance><clinically relevant><clinically significant><cohort><communicable disease control agent><deep sequencing><developmental><digestive canal><drug epidemiology><drug/agent><epidemiologic><epidemiological><experience><graft versus host disease><graft vs host disease><graft vs. host disease><host microbiome><hypoimmunity><immune deficiency><immune reconstitution><immunodeficiency><improved><infection risk><inter-patient variability><interpatient variability><intervention design><intervention research><interventional research><interventional study><interventions research><investigate longitudinal><kids><kinetic model><leukemia><leukemia in children><longitudinal analysis><longitudinal investigation><longitudinal research><microbial consortia><microbial flora><microbiome><microbiome analysis><microbiome research><microbiome science><microbiome sequencing><microbiome studies><microbiota><microflora><multidimensional modeling><multispecies consortia><neutrophil><new marker><novel biomarker><novel marker><patient oriented outcomes><patient oriented research><patient oriented study><patient variability><patient variation><pediatric><pharmacodynamic model><pharmacoepidemiologic><pharmacoepidemiological><pharmacologic><prevent><preventing><progenitor transplantation><rational design><response><skills><statistic methods><stem and progenitor cell transplantations><stem cells><study longitudinal><success><survey longitudinal><therapy design><transplant patient><treatment design><validations><variability between patients><variation between patients><white blood cell><white blood corpuscle><youngster>
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Jennifer Jane Schoch

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$161,568
FY 2026

Project Title

Characterizing the preterm infant skin microbiome and microbial shifts that precede neonatal late onset sepsis (LOS)

Grant Number:

5K23AR081568-04

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Despite recent emphasis on the microbiome, there are few skin microbiome studies in infants; even fewer have been performed in preterm infants. Currently, there is a significant gap in our knowledge of the normal evolution of the preterm infant skin microbiome from birth to an indepe...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Abdominal Delivery><Address><Affect><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antisepsis><Award><Bacteria><Bathing><Baths><Bioinformatics><Birth><C section><Calymmatobacterium><Candida><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Catheters><Cesarean><Cesarean section><Childhood><Chronologic Fetal Maturity><Clinical><Clinical Trials><Collection><Control Groups><Corynebacterium><Cutaneous><Data><Dermatology><Development><Disease><Disorder><Donovania><Early identification><Environment><Ethnic Origin><Ethnicity><Evolution><Exhibits><Failure><Fetal Age><Florida><Functional Metagenomics><Future><Genus staphylococcus><Gestational Age><Goals><Hospital Admission><Hospitalization><Hospitals><Humidity><Incidence><Infant><Intervention Strategies><K-Awards><K-Series Research Career Programs><Klebsiella><Knowledge><Laboratories><Lactobacillus><Lead><Leadership><Learning><Life><Medicine><Mentors><Metagenomics><Methods><Microbe><Microbiomics><Miscellaneous Antibiotic><Monilia><Natural History><Neonatal><Out-patients><Outcome><Outpatients><Parents><Parturition><Pathogenicity><Pb element><Physicians><Predisposition><Premature Infant><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Race><Races><Research><Research Activity><Research Career Program><Research Design><Research Resources><Resources><Risk><Role><Sample Size><Sampling><Science><Scientist><Sepsis><Serratia><Shotguns><Site><Skin><Skin development><Staphylococcus><Streptococcus><Study Type><Susceptibility><Swab><Testing><Therapeutic><Training><Training Activity><Training Programs><Translational Research><Translational Science><Universities><VLBW><Vaginal delivery><Vaginal delivery procedure><Very Low Birth Weight Infant><Work><bacteria pathogen><bacterial pathogen><career><career development><career fair><career networking><cohort><college><collegiate><cutaneous barrier><cutaneous microbiome><cutaneous microbiota><deliver vaginally><dermal barrier><dermal microbiome><dermal microbiota><design><designing><developmental><epidermal barrier><epidermal microbiome><experience><extreme prematurity><extremely premature infant><extremely preterm><extremely preterm infant><feeding><gut microbes><gut microbial species><heavy metal Pb><heavy metal lead><indexing><infants born premature><infants born prematurely><innovate><innovation><innovative><insight><intestinal microbes><investigate longitudinal><large data sets><large datasets><late onset sepsis><longitudinal investigation><longitudinal research><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome community composition><microbiome composition><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiome transplant><microbiome transplantation><microbiota transplant><microbiota transplantation><mortality><neonatal sepsis><novel><opportunistic pathogen><parent><pathogen><pathogen exposure><pathogenic bacteria><pediatric><perinatal complications><premature baby><premature infant human><premature neonates><premature newborn><preterm baby><preterm infant><preterm infant human><preterm neonate><preterm newborn><professional networking><programs><racial><racial background><racial origin><recruit><sex><shot gun><skills><skin barrier><skin biome><skin flora><skin microbial community><skin microbiome><skin microbiota><skin microflora><skin organogenesis><social role><speed networking><statistics><study design><study longitudinal><surveillance strategy><survey longitudinal><training module><translation research><translational investigation><vaginal flora><vaginal microbial community><vaginal microbiota><vaginal microflora><very low birth weight><very premature><very preterm>
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Hanseul Kim

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$151,136
FY 2026

Project Title

Multi-omic approaches to exploring the gut microbiome and metabolic dysfunction-associated steatotic liver disease (MASLD)

Grant Number:

1K01DK141967-01A1

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY While gut microbial communities are implicated in the development and progression of metabolic dysfunction- associated steatotic liver disease (MASLD), formerly known as non-alcoholic fatty liver disease, significant gaps remain in translating this knowledge into patient benefits. Pr...

Research Terms

<Address><Advisory Committees><Bacteria><Bacteriophages><Bifidobacterium><Bile Acids><Biochemical><Biochemistry><Bioinformatics><Biological><Biological Chemistry><Bionomics><Carnitine><Cell Communication and Signaling><Cell Signaling><Chronic><Clinical Trials><Collection><Communities><Computational toolkit><Computing Methodologies><Data><Data Set><Development><Disease><Disorder><Ecology><Enzyme Gene><Enzymes><Epidemiology><Extrahepatic><Feces><Foundations><Functional Metagenomics><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Gnotobiotic><Gnotobiotics><Growth><Health><Hepatic Disorder><Hepatocarcinoma><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Heterogeneity><Human Microbiome><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><In Vitro><Individual><Individual Differences><Inflammatory><Interdisciplinary Research><Interdisciplinary Study><Intermediary Metabolism><Intracellular Communication and Signaling><Investigation><Knowledge><Lactococcus><Lead><Link><Literature><Liver><Liver Cells Carcinoma><Liver diseases><Mediating><Mentorship><Meta-Analysis><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolic dysfunction><Metabolism><Metagenomics><Microbial Genetics><Microbiology><Microbiomics><Mission><Molecular><Molecular Computations><Molecular Fingerprinting><Molecular Profiling><Multidisciplinary Collaboration><Multidisciplinary Research><NAFLD><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Non obese><Nonobese><Nurses><Nurses' Health Study><Obesity><Output><PPAR alpha><PPAR-α><PPARalpha><PPARα><Pathogenicity><Pathway interactions><Patients><Pb element><Peroxisome Proliferator-Activated Receptor alpha><Peroxisome Proliferator-Activated Receptor α><Phages><Position><Positioning Attribute><Prevalence><Primary carcinoma of the liver cells><RNA Expression><Reporting><Research><Risk><Role><Science of Microbial Genetics><Sight><Signal Transduction><Signal Transduction Systems><Signaling><Streptococcus><Task Forces><Tissue Growth><Transcription><Translating><Validation><Variant><Variation><Viral><Vision><acylcarnitine><adiposity><advisory team><bacterial virus><biologic><biological signal transduction><cardiometabolic><cardiometabolism><chronic hepatic disease><chronic hepatic disorder><chronic liver disease><chronic liver disorder><cohort><computational methodology><computational methods><computational toolbox><computational tools><computational toolset><computer based method><computer methods><computerized tools><computing method><corpulence><data integration><design><designing><developmental><dietary><digestive tract microbiome><disease epidemiology><disease risk><disorder risk><enteric microbial community><enteric microbiome><enteric microbiota><epidemiologic><epidemiological><experiment><experimental research><experimental study><experiments><gastrointestinal microbial flora><gastrointestinal microbiome><global gene expression><global transcription profile><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heavy metal Pb><heavy metal lead><hepatic body system><hepatic disease><hepatic organ system><hepatopathy><host microbe association><host microbe relationship><host-microbe interactions><host-microbial interactions><host-microorganism interactions><human-associated microbiome><innovate><innovation><innovative><insight><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><life-style data><lifestyle data><liver carcinoma><liver disorder><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metatranscriptomics><microbial><microbiome><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microorganism genetics><molecular profile><molecular signature><multiomics><multiple omics><non-alcohol fatty liver disease><non-alcoholic fatty liver disease><non-alcoholic liver disease><nonalcoholic fatty liver disease><novel><nurse><ontogeny><panomics><pathway><programs><skills><social role><stool><systematic review><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><transcriptome><transcriptomics><translation strategy><translational approach><translational strategy><translational study><validations><viral microbiome><virome><visual function>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Diana Marie Tordoff

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$131,247
FY 2026

Project Title

The Impact of Menopause Treatments on the Vaginal Microbiome of Peri-menopausal and Post-menopausal Women

Grant Number:

5K01AI182507-03

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/22/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Peri- and post-menopausal women experience dysbiosis of the vaginal microbiota, characterized by a non-Lactobacillus dominant microbiome and higher microbial richness. However, there is a critical need to better characterize how the initiation and cessation of interventions used to manage menopause ...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Address><Age><Atrophic><Atrophy><Bioinformatics><Biologic Factor><Biological Factors><Body Tissues><Clinical><Clinical Management><Clinical Trials><Complementarity Determining Regions><Complimentarity Determining Region><Cytology><Data><Decision Making><Development><Development Plans><Drug Therapy><Endocrine><Endometrial Cancer><Endometrial Carcinoma><Endometrium Cancer><Endometrium Carcinoma><Environment><Epidemiologic Determinants><Epidemiologic Factors><Epidemiologic Research><Epidemiological Factors><Epidemiology><Evidence based intervention><Female Health><Fostering><Funding><General Taxonomy><Genital Organs><Genitalia><Genitourinary><Genitourinary system><Goals><Gynecologic><HPV infection><HPV-High Risk><Health><High Risk Oncogenic HPV><High risk HPV><High risk Human Papillomavirus><High risk Human papilloma virus><Human papilloma virus infection><Human papillomavirus infection><Hypervariable Loop><Hypervariable Regions><Hysterectomy><Immunoglobulin Hypervariable Region><Individual><Infection><Intervention><Investigators><Lactobacillus><Measures><Mediating><Menopausal Symptom><Menopause><Mentors><Mentorship><Microbiomics><Miscarriage><Ovarian><Participant><Patients><Perimenopausal><Perimenopause><Pharmacological Treatment><Pharmacotherapy><Post-Menopause><Post-menopausal Period><Postmenopausal Period><Postmenopause><Premature Birth><Prematurely delivering><Preterm Birth><Psyche structure><Qualifying><Recurrence><Recurrent><Research><Research Infrastructure><Research Personnel><Researchers><Risk><Severities><Sexual Health><Spontaneous abortion><Swab><Symptoms><Taxonomy><Time><Tissues><Training><Translational Research><Translational Science><Universities><Urogenital><Urogenital System><Vagina><Vasomotor><Withholding Treatment><Woman><Women's Health><after menopause><ages><career><career development><cessation of treatment><cohort><developmental><drug intervention><drug treatment><dysbacteriosis><dysbiosis><dysbiotic><epidemiologic><epidemiologic investigation><epidemiological><experience><following menopause><healthy aging><healthy human aging><hrHPV><improved><indexing><infected vaginally><innovate><innovation><innovative><investigate epidemiology><life span><lifespan><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><menopausal aging><menopause transition><mental><microbial><microbial composition><microbial imbalance><microbiome><microbiome research><microbiome science><microbiome studies><microbiota composition><past menopause><peri-menopausal><peri-menopause><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><post-menopausal><postmenopausal><postmenopausal status><premature childbirth><premature delivery><preterm delivery><prevent><preventing><programs><recruit><social><study epidemiology><survey epidemiology><transition to menopause><transitional menopause><translation research><translational investigation><treatment cessation><vaginal biome><vaginal flora><vaginal infection><vaginal microbial community><vaginal microbiome><vaginal microbiota><vaginal microflora>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Darby Jack

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 48/100
Likely hiring
Recent
Active award
$118,029
FY 2026

Project Title

Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the GRAPHS randomized controlled trial

Grant Number:

3R01ES035791-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/17/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project summary In low- and middle-income countries ~2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M disability adjusted life years in 2019. A large proportion of HAP-attributable deaths are due t...

Research Terms

<0-11 years old><1 year of age><1 year old><13 year old><13 years of age><16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><3-D><3-Dimensional><3D><4 year old><4 years of age><5 year old><5 years of age><Address><Age><Air Pollution><Animal Model><Animal Models and Related Studies><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Asthma><Bacteria><Bacteriophages><Biogenesis><Birth><Breathing><Bronchial Asthma><Carbon Monoxide><Causality><Cessation of life><Child><Child Youth><Childhood><Children (0-21)><Communities><Crude Oil><DALY><Death><Development><Disease><Disorder><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Epidemiology><Etiology><Exposure Assessment><Feces><Fire - disasters><Fires><Functional Metagenomics><Future><GI microbiome><Gases><Generalized Growth><Gestation><Ghana><Gold Coast><Grant><Growth><Health><Heterogeneity><Household><Household Air Pollution><Human><Human Microbiome><Hybrid capture><Hybridization capture><Infant><Intention><Intervention><Investments><LMIC><Life><Life Cycle><Life Cycle Stages><Link><Lung Diseases><Measurement><Mediating><Metagenomics><Methods><Modern Man><Origin of Life><Outcome Assessment><PM2.5><Parturition><Persons><Petroleum><Phages><Phenotype><Pneumonia><Policies><Pregnancy><Pregnant Women><Preventative intervention><Process><Public Health><Pulmonary Diseases><Pulmonary Disorder><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Randomized, Controlled Trials><Research><Research Grants><Research Project Grants><Research Projects><Respiratory Aspiration><Respiratory Disease><Respiratory Inspiration><Respiratory System Disease><Respiratory System Disorder><Risk><Risk Reduction><Shotguns><Smoke><Therapeutic Intervention><Time><Tissue Growth><Viral><Virus><Wood><Wood material><Work><age 1><age 1 year><age 13><age 13 years><age 4><age 4 years><age 5><age 5 years><aged 1 year><aged one year><ages><arm><attributable death><attributable mortality><bacterial microbiome><bacterial virus><bacteriome><biomarker identification><candidate identification><causation><childhood gut microbiome><cohort><compare to control><comparison control><cooking><cost effective><developmental><digestive tract microbiome><disability-adjusted life years><discrete time><disease causation><disease of the lung><disease risk><disorder of the lung><disorder risk><early biomarkers><early detection biomarkers><early detection markers><enteric microbiome><environmental risk><epidemiologic><epidemiological><evidence base><expectant mother><expectant women><expecting mother><expecting women><exposure analysis><exposure evaluation><exposure measurement><exposure profiling><exposure survey><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><fine particles><fine particulate matter><fire><five year old><five years of age><four year old><four years of age><fungus><gastrointestinal microbiome><gut microbiome><gut microbiome of infant><gut-associated microbiome><human flora><human microbial communities><human microbiota><human microflora><human virome><human-associated microbial communities><human-associated microbiome><human-associated microbiota><hybridization-based capture><identification of biomarkers><identification of new biomarkers><improved><individuals who are pregnant><infancy><infant gut microbiome><infantile><inspiration><intervention for prevention><intervention therapy><intestinal biome><intestinal microbiome><kids><life course><low and middle-income countries><lung disorder><lung function><lung health><marker identification><maternal microbiome><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome signature><model of animal><neonate gut microbiome><newborn gut microbiome><novel><one year of age><one year old><ontogeny><pediatric><pediatric gut microbiome><people who are pregnant><petroleum oil><pollutant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prevention intervention><preventional intervention strategy><preventive intervention><programs><public health intervention><pulmonary function><pulmonary health><randomisation><randomization><randomized control study><randomized control trial><randomized, controlled study><randomly assigned><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><residential air pollution><response><risk-reducing><shot gun><stool><stool sample><stool specimen><thirteen year old><thirteen years of age><those who are pregnant><three dimensional><treatment group><unborn><viral microbiome><virome><women who are pregnant><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Peggy Sue Lai

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 48/100
Likely hiring
Recent
Active award
$118,029
FY 2026

Project Title

Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the GRAPHS randomized controlled trial

Grant Number:

3R01ES035791-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/17/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project summary In low- and middle-income countries ~2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M disability adjusted life years in 2019. A large proportion of HAP-attributable deaths are due t...

Research Terms

<0-11 years old><1 year of age><1 year old><13 year old><13 years of age><16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><3-D><3-Dimensional><3D><4 year old><4 years of age><5 year old><5 years of age><Address><Age><Air Pollution><Animal Model><Animal Models and Related Studies><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Asthma><Bacteria><Bacteriophages><Biogenesis><Birth><Breathing><Bronchial Asthma><Carbon Monoxide><Causality><Cessation of life><Child><Child Youth><Childhood><Children (0-21)><Communities><Crude Oil><DALY><Death><Development><Disease><Disorder><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Epidemiology><Etiology><Exposure Assessment><Feces><Fire - disasters><Fires><Functional Metagenomics><Future><GI microbiome><Gases><Generalized Growth><Gestation><Ghana><Gold Coast><Grant><Growth><Health><Heterogeneity><Household><Household Air Pollution><Human><Human Microbiome><Hybrid capture><Hybridization capture><Infant><Intention><Intervention><Investments><LMIC><Life><Life Cycle><Life Cycle Stages><Link><Lung Diseases><Measurement><Mediating><Metagenomics><Methods><Modern Man><Origin of Life><Outcome Assessment><PM2.5><Parturition><Persons><Petroleum><Phages><Phenotype><Pneumonia><Policies><Pregnancy><Pregnant Women><Preventative intervention><Process><Public Health><Pulmonary Diseases><Pulmonary Disorder><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Randomized, Controlled Trials><Research><Research Grants><Research Project Grants><Research Projects><Respiratory Aspiration><Respiratory Disease><Respiratory Inspiration><Respiratory System Disease><Respiratory System Disorder><Risk><Risk Reduction><Shotguns><Smoke><Therapeutic Intervention><Time><Tissue Growth><Viral><Virus><Wood><Wood material><Work><age 1><age 1 year><age 13><age 13 years><age 4><age 4 years><age 5><age 5 years><aged 1 year><aged one year><ages><arm><attributable death><attributable mortality><bacterial microbiome><bacterial virus><bacteriome><biomarker identification><candidate identification><causation><childhood gut microbiome><cohort><compare to control><comparison control><cooking><cost effective><developmental><digestive tract microbiome><disability-adjusted life years><discrete time><disease causation><disease of the lung><disease risk><disorder of the lung><disorder risk><early biomarkers><early detection biomarkers><early detection markers><enteric microbiome><environmental risk><epidemiologic><epidemiological><evidence base><expectant mother><expectant women><expecting mother><expecting women><exposure analysis><exposure evaluation><exposure measurement><exposure profiling><exposure survey><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><fine particles><fine particulate matter><fire><five year old><five years of age><four year old><four years of age><fungus><gastrointestinal microbiome><gut microbiome><gut microbiome of infant><gut-associated microbiome><human flora><human microbial communities><human microbiota><human microflora><human virome><human-associated microbial communities><human-associated microbiome><human-associated microbiota><hybridization-based capture><identification of biomarkers><identification of new biomarkers><improved><individuals who are pregnant><infancy><infant gut microbiome><infantile><inspiration><intervention for prevention><intervention therapy><intestinal biome><intestinal microbiome><kids><life course><low and middle-income countries><lung disorder><lung function><lung health><marker identification><maternal microbiome><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome signature><model of animal><neonate gut microbiome><newborn gut microbiome><novel><one year of age><one year old><ontogeny><pediatric><pediatric gut microbiome><people who are pregnant><petroleum oil><pollutant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prevention intervention><preventional intervention strategy><preventive intervention><programs><public health intervention><pulmonary function><pulmonary health><randomisation><randomization><randomized control study><randomized control trial><randomized, controlled study><randomly assigned><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><residential air pollution><response><risk-reducing><shot gun><stool><stool sample><stool specimen><thirteen year old><thirteen years of age><those who are pregnant><three dimensional><treatment group><unborn><viral microbiome><virome><women who are pregnant><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Alison G Lee

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 48/100
Likely hiring
Recent
Active award
$118,029
FY 2026

Project Title

Prenatal and infant household air pollution exposure, the human microbiome and virome, and childhood lung function: the GRAPHS randomized controlled trial

Grant Number:

3R01ES035791-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/17/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project summary In low- and middle-income countries ~2.8 billion people are exposed daily to smoke from cooking fires, termed household air pollution (HAP), resulting in an estimated 2.3M deaths and 91.4M disability adjusted life years in 2019. A large proportion of HAP-attributable deaths are due t...

Research Terms

<0-11 years old><1 year of age><1 year old><13 year old><13 years of age><16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><3-D><3-Dimensional><3D><4 year old><4 years of age><5 year old><5 years of age><Address><Age><Air Pollution><Animal Model><Animal Models and Related Studies><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Asthma><Bacteria><Bacteriophages><Biogenesis><Birth><Breathing><Bronchial Asthma><Carbon Monoxide><Causality><Cessation of life><Child><Child Youth><Childhood><Children (0-21)><Communities><Crude Oil><DALY><Death><Development><Disease><Disorder><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Epidemiology><Etiology><Exposure Assessment><Feces><Fire - disasters><Fires><Functional Metagenomics><Future><GI microbiome><Gases><Generalized Growth><Gestation><Ghana><Gold Coast><Grant><Growth><Health><Heterogeneity><Household><Household Air Pollution><Human><Human Microbiome><Hybrid capture><Hybridization capture><Infant><Intention><Intervention><Investments><LMIC><Life><Life Cycle><Life Cycle Stages><Link><Lung Diseases><Measurement><Mediating><Metagenomics><Methods><Modern Man><Origin of Life><Outcome Assessment><PM2.5><Parturition><Persons><Petroleum><Phages><Phenotype><Pneumonia><Policies><Pregnancy><Pregnant Women><Preventative intervention><Process><Public Health><Pulmonary Diseases><Pulmonary Disorder><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Randomized, Controlled Trials><Research><Research Grants><Research Project Grants><Research Projects><Respiratory Aspiration><Respiratory Disease><Respiratory Inspiration><Respiratory System Disease><Respiratory System Disorder><Risk><Risk Reduction><Shotguns><Smoke><Therapeutic Intervention><Time><Tissue Growth><Viral><Virus><Wood><Wood material><Work><age 1><age 1 year><age 13><age 13 years><age 4><age 4 years><age 5><age 5 years><aged 1 year><aged one year><ages><arm><attributable death><attributable mortality><bacterial microbiome><bacterial virus><bacteriome><biomarker identification><candidate identification><causation><childhood gut microbiome><cohort><compare to control><comparison control><cooking><cost effective><developmental><digestive tract microbiome><disability-adjusted life years><discrete time><disease causation><disease of the lung><disease risk><disorder of the lung><disorder risk><early biomarkers><early detection biomarkers><early detection markers><enteric microbiome><environmental risk><epidemiologic><epidemiological><evidence base><expectant mother><expectant women><expecting mother><expecting women><exposure analysis><exposure evaluation><exposure measurement><exposure profiling><exposure survey><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><fine particles><fine particulate matter><fire><five year old><five years of age><four year old><four years of age><fungus><gastrointestinal microbiome><gut microbiome><gut microbiome of infant><gut-associated microbiome><human flora><human microbial communities><human microbiota><human microflora><human virome><human-associated microbial communities><human-associated microbiome><human-associated microbiota><hybridization-based capture><identification of biomarkers><identification of new biomarkers><improved><individuals who are pregnant><infancy><infant gut microbiome><infantile><inspiration><intervention for prevention><intervention therapy><intestinal biome><intestinal microbiome><kids><life course><low and middle-income countries><lung disorder><lung function><lung health><marker identification><maternal microbiome><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome signature><model of animal><neonate gut microbiome><newborn gut microbiome><novel><one year of age><one year old><ontogeny><pediatric><pediatric gut microbiome><people who are pregnant><petroleum oil><pollutant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prevention intervention><preventional intervention strategy><preventive intervention><programs><public health intervention><pulmonary function><pulmonary health><randomisation><randomization><randomized control study><randomized control trial><randomized, controlled study><randomly assigned><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><residential air pollution><response><risk-reducing><shot gun><stool><stool sample><stool specimen><thirteen year old><thirteen years of age><those who are pregnant><three dimensional><treatment group><unborn><viral microbiome><virome><women who are pregnant><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Golnaz Morad

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$112,026
FY 2026

Project Title

The role of oral microbiota in metastatic brain tumors

Grant Number:

5K99CA296780-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/10/2025

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Brain metastasis is a major clinical challenge associated with high morbidity and mortality. Growing evidence suggests a critical role for the immune system in the pathophysiology of brain metastasis. Our group and others have demonstrated that microbiota, i.e. the assembly of micro...

Research Terms

<21+ years old><Adult><Adult Human><Advisory Committees><Anti-Bacterial Response><Antibacterial Response><Award><Bacterial Translocation><Biological Response Modifiers><Biomodulators><Brain><Brain Metastasis><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><Buccal Cavity><Buccal Cavity Head and Neck><Cancer Center><Cancers><Cavitas Oris><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Characteristics><Clinical><Clinical Research><Clinical Study><Development><Development Plans><Development and Research><Diagnostic><Dimensions><Disease><Disease Outcome><Disorder><Dysfunction><Encephalon><Environment><Exhibits><Foundations><Functional disorder><Goals><Gum Disease><Hortega cell><Human Figure><Human body><Immune><Immune Mediators><Immune Mediators/Modulators><Immune infiltrates><Immune response><Immune system><Immunes><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Infiltration><Innate Immunity><Intracellular Communication and Signaling><Investigation><Knowledge><MDACC><Malignant Melanoma><Malignant Neoplasms><Malignant Tumor><Melanoma><Mentors><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Brain><Metastatic Tumor><Metastatic Tumor to the Brain><Metastatic malignant neoplasm to brain><Methods><Mice><Mice Mammals><Microbe><Microglia><Monitor><Morbidity><Mouth><Mouth microbiome><Murine><Mus><Native Immunity><Natural Immunity><Neoplasm Metastasis><Non-Specific Immunity><Nonspecific Immunity><Oral><Oral cavity><Outcome><Parodontosis><Patients><Periodontal Diseases><Phagocytes><Phagocytic Cell><Phase><Physiopathology><Play><Postdoc><Postdoctoral Fellow><Preventative intervention><Preventive><Primary Neoplasm><Primary Tumor><R & D><R&D><Radio><Research><Research Associate><Role><Route><Sampling><Secondary Neoplasm><Secondary Tumor><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Source><Supervision><Task Forces><Therapeutic><Therapeutic Intervention><Time><Training><Training Activity><Transcription Alteration><Translational Research><Translational Science><Tumor Cell><Tumor Immunity><University of Texas M D Anderson Cancer Center><University of Texas MD Anderson Cancer Center><Visualization><adulthood><advisory team><amebocyte><anti-cancer research><anti-tumor effect><anti-tumor immune response><anti-tumor immunity><antitumor effect><antitumor immunity><behavior change><biological signal transduction><brain micrometastasis><brain tissue><cancer immunity><cancer immunology><cancer metastasis><cancer microenvironment><cancer research><career><career development><chemotherapy><clinical care><cohort><community microbes><cost effective><developmental><digital><dysbacteriosis><dysbiosis><dysbiotic><gitter cell><host response><immune cell infiltrate><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved><improved outcome><inflammatory environment><inflammatory milieu><insight><intervention for prevention><intervention therapy><malignancy><melanoma cancer model><melanoma model><melanoma tumor model><mesoglia><microbe community><microbial community><microbial consortia><microbial flora><microbial imbalance><microbial signature><microbiome><microbiota><microflora><microglial cell><microgliocyte><microorganism community><migration><mortality><mouse model><multispecies consortia><murine model><neoplasm immunology><neoplasm/cancer><neoplastic cell><neural inflammation><neuroinflammation><neuroinflammatory><new diagnostics><next generation diagnostics><novel><novel diagnostics><oral bacteria><oral flora><oral microbial community><oral microbiome><oral microbiota><oral microflora><pathophysiology><periodontal disorder><periodontium disease><periodontium disorder><perivascular glial cell><polymicrobial community><post-doc><post-doctoral><post-doctoral trainee><prevention intervention><preventional intervention strategy><preventive intervention><prospective><research and development><research associates><response><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><training module><translation research><translational investigation><tumor><tumor cell metastasis><tumor immunology><tumor microbiome><tumor microenvironment><tumor-associated microbiome><tumors in the brain>
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Tadashi Takeuchi

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$91,500
FY 2026

Project Title

Harnessing Metabolic Machinery of Gut Bacteria for Metabolic Dysfunction-Associated Steatohepatitis

Grant Number:

1K99DK146142-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/6/2026

End Date:

1/31/2028

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  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Metabolic dysfunction-associated steatohepatitis (MASH) is a growing public health concern in industrialized nations, with an estimated cost of $1.66 trillion in the U.S. by 2039. Despite its prevalence, therapeutic strategies remain limited due to an incomplete understandin...

Research Terms

<Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antiinflammatory Effect><Award><Bacteria><Bacterial Genes><Biological><Biology><Biomedical Research><Bionomics><C butyricum><C. butyricum><Cell Body><Cells><Clostridium butyricum><Collection><Complex><Data Bases><Databases><Developed Countries><Diet><Dietary Polysaccharide><Ecology><Engraftment><Equipment><Experimental Models><Fibrosis><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional Metagenomics><GI colonization><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Genes><Genome><Glycans><Goals><Growth><Health><Health Promotion><Hepatic Disorder><Human><Hydroxy Acids><Immune><Immunes><Individual><Indoles><Industrialization><Industrialized Countries><Industrialized Nations><Inflammation><Inflammatory><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Liver><Liver diseases><Macrophage><Maps><Mentors><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic dysfunction><Metagenomics><Methods><Mice><Mice Mammals><Microbiology><Microbiomics><Modeling><Modern Man><Molecular><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Mφ><NK T cell><NKT cell><Natural Killer T cell><Nutrient><Oral Administration><Oral Drug Administration><Pathogenesis><Plants><Play><Polysaccharides><Population><Portal Vein><Portal vein structure><Prevalence><Process><Production><Public Health><Research><Research Personnel><Research Resources><Researchers><Resolution><Resources><Role><Salutogenesis><Short-Chain Fatty Acids><Steatohepatitis><Tanzania><Therapeutic><Therapeutic Effect><Thesaurismosis><Tissue Growth><Training><Universities><Volatile Fatty Acids><anti-inflammatory effect><bacteria in the gut><bacteria metabolism><bacterial metabolism><biologic><branched chain fatty acid><career development><combat><cost estimate><cost estimation><cytokine><data base><developed country><developed nation><developed nations><dietary><diets><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal sample><fecal transplant><fecal transplantation><flow cytophotometry><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><gut bacteria><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hepatic body system><hepatic disease><hepatic inflammation><hepatic organ system><hepatopathy><hydroxyacid><improved><inflamed liver><insight><intestinal biome><intestinal colonization><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intraoral drug delivery><liver disorder><liver inflammation><metabolism disorder><metabolism measurement><metabolomics><metabonomics><microbial consortia><microbial flora><microbiome><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><mouse model><multispecies consortia><murine model><natural killer T lymphocyte><new approaches><novel approaches><novel strategies><novel strategy><ontogeny><programs><promoting health><rational design><resolutions><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skill acquisition><skill development><skills><social role><stool sample><stool specimen><translation strategy><translational approach><translational strategy>
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Magdalena Sevilla Gonzalez

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$90,000
FY 2026

Project Title

Integration of dietary factors and multi-omic signatures of genetic subtypes to understand diabetes heterogeneity

Grant Number:

5K99DK139461-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Why this may be worth a closer look

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Project Abstract

PROJECT SUMMARY/ABSTRACT Type 2 diabetes (T2D) is a heterogeneous disease that is the result of the interaction between environmental and genetic factors. T2D heterogeneity has been described with a set of reproducible T2D genetic subtypes representing the contribution of specific pathways such as i...

Research Terms

<Adult-Onset Diabetes Mellitus><Affect><American><Amino Acids><Biological><Black Populations><Black group><Black individual><Black people><Blacks><Ch'i><Complex><Data><Diabetes Mellitus><Diagnosis><Diet><Dietary Factors><Dietary Intervention><Dietary Practices><Disease><Disorder><Doctor of Philosophy><Environment><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Fats><Fatty acid glycerol esters><GI microbiome><Genetic><Genetic Diversity><Genetic Models><Genetic Variation><Genomics><Goals><Heterogeneity><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Individual><Insulin Resistance><Intermediary Metabolism><Intervention><Ketosis-Resistant Diabetes Mellitus><Lipids><Maturity-Onset Diabetes Mellitus><Measures><Mediating><Mediation><Mentorship><Metabolic><Metabolic Processes><Metabolism><Mission><Modeling><Modification><Molecular><Molecular Fingerprinting><Molecular Profiling><NIDDK><NIDDM><NIH><National Institute of Diabetes and Digestive and Kidney Diseases><National Institutes of Health><Negotiating><Negotiation><Non-Hispanic><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Nonhispanic><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Not Hispanic or Latino><Nutrient><Nutrition><Nutrition Interventions><Nutritional Interventions><Outcome><Pathway interactions><Patients><Ph.D.><PhD><Phase><Physiology><Population><Population Genetics><Population Heterogeneity><Position><Positioning Attribute><Precision Health><Process><Public Health><Qi><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Reproducibility><Research><Research Grants><Research Project Grants><Research Projects><Slow-Onset Diabetes Mellitus><Source><Stable Diabetes Mellitus><Strategic Planning><Subgroup><T2 DM><T2D><T2DM><TOPMed><Technology><Testing><Training><Trans-Omics for Precision Medicine><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States National Institutes of Health><Variant><Variation><Work><adult onset diabetes><aminoacid><biologic><career><clinical applicability><clinical application><clinical epidemiology><cohort><diabetes><diabetes genetics><diabetes mellitus genetics><diabetes risk><diet intervention><dietary pattern><diets><digestive tract microbiome><diverse populations><enteric microbiome><environmental risk><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><gastrointestinal microbiome><gene signatures><genetic signature><gut microbiome><gut-associated microbiome><heterogeneous population><human disease><improved><insulin resistant><insulin secretion><insulin tolerance><inter-individual variability><inter-individual variation><intestinal biome><intestinal microbiome><ketosis resistant diabetes><maturity onset diabetes><member><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbiome signature><molecular profile><molecular signature><multiomics><multiple omics><panomics><pathway><polygenetic risk scores><polygenic predictors><polygenic risk score><polygenic scores><population diversity><precision medicine><precision nutrition><precision-based medicine><prevent><preventing><programs><randomisation><randomization><randomly assigned><response><therapeutic target><type 2 DM><type II DM><type two diabetes>
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David M. James

UNIVERSITY OF OREGON, EUGENE, OR

Good lead · 48/100
Training-friendly
Very recent
Active award
$81,580
FY 2026

Project Title

Microbiome Modulation of Visual System Development

Grant Number:

5F32EY035578-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

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Project Abstract

PROJECT SUMMARY Visual system dysfunction is a common and debilitating comorbidity for individuals diagnosed with a variety of neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), schizophrenia, and attention deficit hyperactivity disorder. The microbiome is emerging as an ...

Research Terms

<AD/HD><ADHD><ASD><Ablation><Anatomic Sites><Anatomic structures><Anatomy><Anterior Quadrigeminal Body><Antimorphic mutation><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Automobile Driving><Behavior><Behavioral><Bioinformatics><Biologic Models><Biological Models><Brachydanio rerio><Brain><Brain Nervous System><CNS Nervous System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell secretion><Cells><Cellular Secretion><Central Nervous System><Communication><Complex><Connector Neuron><Cranial Nerve X><Cues><Danio rerio><Data><Development><Diagnosis><Dominant Negative><Dominant-Negative Mutant><Dominant-Negative Mutation><Dysfunction><Early Infantile Autism><Encephalon><Enteroendocrine Cell><Foundations><Functional disorder><GI microbiome><Germ-Free><Glycohydrolases><Glycosidases><Glycoside Hydrolases><Gnotobiotic><Gnotobiotics><Goals><Gut Epithelium><Health><Human><Individual><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Interneuron function><Interneurons><Internuncial Cell><Internuncial Neuron><Intervention><Intestinal><Intestines><Intracellular Communication and Signaling><Kanner's Syndrome><Knowledge><Larva><Link><Location><Mediating><Model System><Modeling><Modern Man><Molecular><Molecular Weight><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neuraxis><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Neurosciences><Optic Tectum><Outcome><Output><Pathway interactions><Peripheral><Phenotype><Photic Stimulation><Physiopathology><Play><Pneumogastric Nerve><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Research><Role><Schizophrenia><Schizophrenic Disorders><Sensory><Shewanella><Sight><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Superior Colliculus><Swimming><Systems Development><TLR protein><Tenth Cranial Nerve><Testing><Toll-Like Receptor Family Gene><Toll-like receptors><Vagus Nerve><Vagus nerve structure><Vision><Visual><Visual Stimulation><Visual System><Work><Zebra Danio><Zebra Fish><Zebrafish><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><bacteria in the gut><biological signal transduction><bowel><cell type><co-morbid><co-morbidity><comorbidity><dementia praecox><developmental><digestive tract microbiome><driving><dysbacteriosis><dysbiosis><dysbiotic><effective therapy><effective treatment><enteric microbiome><gastrointestinal epithelium><gastrointestinal microbiome><gut bacteria><gut microbiome><gut-associated microbiome><host microbe association><host microbe relationship><host-associated microbes><host-associated microbial communities><host-associated microbiota><host-associated microorganisms><host-microbe interactions><host-microbial interactions><host-microorganism interactions><intestinal biome><intestinal microbiome><microbial><microbial consortia><microbial flora><microbial imbalance><microbial products><microbiome><microbiota><microflora><multispecies consortia><mutant><nervous system development><neural><neurodevelopment><neurodevelopmental disease><neuronal><pathophysiology><pathway><prevent><preventing><response><schizophrenic><social role><superior colliculus Corpora quadrigemina><symbiont><vision development><visual development><visual function><visual process><visual processing><visual stimulus><visual system development><visual tectum>
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Anna Thuy Nhu Nguyen

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 48/100
Training-friendly
Very recent
Active award
$43,925
FY 2026

Project Title

Evaluating the causal effects of anti-malarial chemoprevention in pregnancy and childhood on growth outcomes

Grant Number:

5F31AI179107-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/11/2024

End Date:

8/10/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Malaria and growth faltering continue to be major causes of child morbidity and mortality in sub- Saharan Africa where over 400,000 children under the age of 5 die from malaria1 and 57 million children are stunted2 each year. Given the high co-prevalence of these conditions in the r...

Research Terms

<0-11 years old><1 year of age><1 year old><2 year old><2 years of age><5 year old><5 years of age><Address><Affect><Africa South of the Sahara><Anti-malarials><Award><Biological><Biological Markers><Birth><Birth Weight><Blood Sample><Blood specimen><Chemoprevention><Child><Child Development><Child Health><Child Youth><Childhood><Children (0-21)><Communicable Diseases><Data><Data Analyses><Data Analysis><Development><Dietary Intervention><Effectiveness><Epidemiology><Equation><Failure><Fellowship><Foundations><Future><GI microbiome><Generalized Growth><Geography><Gestation><Goals><Growth><Height><Incidence><Individual><Infant><Infant and Child Development><Infection><Infectious Disease Epidemiology><Infectious Diseases><Infectious Disorder><Infectious Epidemiology><Inflammation><Inflammatory><Influentials><Intervention><Intervention Trial><Interventional trial><Investigators><LMIC><Lead><Life><Low Birth Weight Infant><Malaria><Malaria prevention><Measurement><Measures><Mediating><Mediation><Mediator><Mentorship><Methodology><Methods><Morbidity><Mothers><Negotiating><Negotiation><Neonatal><Nutrition Interventions><Nutritional Interventions><Outcome><Paludism><Parturition><Pathway interactions><Pb element><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Placebos><Plasmodium Infections><Population><Position><Positioning Attribute><Pregnancy><Pregnant Women><Prevalence><Preventative treatment><Prevention><Preventive treatment><Randomization trial><Randomized><Regimen><Research><Research Personnel><Researchers><Risk><Risk Factors><Sampling><Series><Sham Treatment><Sub-Saharan Africa><Subsaharan Africa><Sulfadoxine><Sulformethoxine><Sulformetoxine><Sulforthomidine><Sulphormetoxin><Tissue Growth><Training><Transmission><Uganda><Weight><Work><age 1><age 1 year><age 2><age 2 years><age 5><age 5 years><aged 1 year><aged 2 years><aged one year><aged two years><analyze microbiome><anti-malarial agents><anti-malarial drugs><bio-markers><biologic><biologic marker><biomarker><career><career development><data interpretation><design><designing><developmental><diet intervention><digestive tract microbiome><doctoral student><dysbacteriosis><dysbiosis><dysbiotic><early childhood><early onset><effective intervention><enteric microbiome><epidemiologic><epidemiological><expectant mother><expectant women><expecting mother><expecting women><fecal sample><five year old><five years of age><future implementation><gastrointestinal microbiome><global health><gut microbiome><gut-associated microbiome><heavy metal Pb><heavy metal lead><high risk><improved><individuals who are pregnant><infancy><infantile><inflammation in mothers><intestinal biome><intestinal microbiome><kids><low and middle-income countries><low birth weight><low birthweight><malaria infection><malaria transmission><malaria-infected><malarial infection><maternal inflammation><medical college><medical schools><microbial imbalance><microbiome><microbiome analysis><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><mortality><mother inflammation><one year of age><one year old><ontogeny><pathway><pediatric><people who are pregnant><population health><post-natal period><postnatal period><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prevent><prevent malaria><preventing><programs><randomisation><randomization><randomized trial><randomly assigned><school of medicine><sham therapy><site targeted delivery><skills><stool sample><stool specimen><systemic inflammation><systemic inflammatory response><targeted delivery><those who are pregnant><transmission process><two year old><two years of age><unborn><wasting><weights><women who are pregnant><youngster>
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Yelizaveta Rassadkina

DUKE UNIVERSITY, DURHAM, NC

Good lead · 48/100
Training-friendly
Very recent
Active award
$43,459
FY 2026

Project Title

Genetic analysis of competition dependent fitness determinants in the human gut bacterium Phocaeicola vulgatus

Grant Number:

5F31AI181537-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

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Project Abstract

ABSTRACT The mammalian gut harbors complex communities of microbes that interact and compete with each other while also influencing the physiology of the host. Discerning the mechanisms by which major members of these microbial communities colonize the gut is a fundamentally important research goal....

Research Terms

<21+ years old><Address><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><Alimentary Canal><Amines><Anaerobic Bacteria><Antibodies><Assay><Binding><Binding Proteins><Bioassay><Biological Assay><Birth><Carrier Proteins><Cell Body><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Code><Coding System><Complex><Coupled><DNA-Binding Proteins><Data><Development><Digestive Tract><Disease><Disorder><Ecologic Systems><Ecological Systems><Ecosystem><Environment><Fatty Acids><GI Tract><GI colonization><GI microbiome><GI microbiota><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Gene Down-Regulation><Gene Transcription><Genes><Genetic Transcription><Genome><Germ-Free><Goals><Health><Health Promotion><Human><Immobilization><Immune Precipitation><Immunoblotting><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Immunoprecipitation><In Vitro><Infiltration><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal><Intestines><Invaded><Ketosis-Resistant Diabetes Mellitus><Knock-out><Knockout><Knowledge><Label><Large Intestine><Libraries><Ligand Binding Protein><Ligand Binding Protein Gene><Link><Lipid Binding><Lipid Trafficking><Lipids><Location><Mammalia><Mammals><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Maturity-Onset Diabetes Mellitus><Mediating><Metabolic Diseases><Metabolic Disorder><Mice><Mice Mammals><Microbe><Mission><Modern Man><Molecular><Molecular Interaction><Murine><Mus><NAFLD><NIDDM><NIH><National Institutes of Health><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Operon><Outcome><Outcome Study><Parturition><Peptide Signal Sequences><Phosphatides><Phospholipids><Physiologic><Physiological><Physiology><Play><Polycystic Ovarian Disease><Polycystic Ovarian Syndrome><Polycystic Ovary Syndrome><Probiotics><Protein Binding><Protein Secretion><Protein Trafficking><Proteins><Public Health><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Research><Role><Salutogenesis><Sclerocystic Ovarian Degeneration><Sclerocystic Ovary Syndrome><Signal Peptide><Signal Sequences><Slow-Onset Diabetes Mellitus><Small Intestines><Stable Diabetes Mellitus><T2 DM><T2D><T2DM><Testing><Thesaurismosis><Tissue Sample><Transcription><Transcription Repression><Transcription Repressor><Transcriptional Repressor><Transport Protein Gene><Transport Proteins><Transporter Protein><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States National Institutes of Health><Western Blotting><Western Immunoblotting><Work><adult onset diabetes><adulthood><alimentary tract><amine><anaerobe><bacteria in the gut><bound protein><bowel><burden of disease><burden of illness><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><community microbes><developmental><digestive canal><digestive tract microbiome><disease burden><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><fatty acid-transport protein><fitness><fluorescence imaging><fluorescent imaging><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><gene function><gene manipulation><gene product><gene repression><genetic analysis><genetic manipulation><genetic repressor><genetically manipulate><genetically perturb><germ free condition><gut bacteria><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><improved><in vivo><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><intestinal autoinflammation><intestinal biome><intestinal colonization><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><ketosis resistant diabetes><large bowel><lipid bound><lipid transport><maturity onset diabetes><member><metabolism disorder><metabolism measurement><metabolomics><metabonomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microflora><microorganism><microorganism community><multispecies consortia><mutant><new approaches><non-alcohol fatty liver disease><non-alcoholic fatty liver disease><non-alcoholic liver disease><nonalcoholic fatty liver disease><novel approaches><novel strategies><novel strategy><orthopedic freezing><polycystic ovary><polycystic ovary disease><polycystic ovary disorder><polymicrobial community><promoting health><protein blotting><protein function><protein signal sequence><protein transport><small bowel><social role><specific pathogen free><tool><transcriptome sequencing><transcriptomic sequencing><type 2 DM><type II DM><type two diabetes>
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Elizabeth A Brown

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 48/100
Training-friendly
Very recent
Active award
$43,313
FY 2026

Project Title

The Impact of Bile Salt Hydrolase on Intestinal T Cells in Colitis

Grant Number:

1F31DK145221-01A1

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/26/2026

End Date:

3/25/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Inflammatory bowel disease (IBD) affects up to 3.1 million adults in the U.S. Bile acids are recognized as key signaling molecules in microbe-immune communication and may therefore be new therapeutic targets for IBD. Microbes deconjugate bile acids with bile salt hydrolases...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Amino Acids><Animal Model><Animal Models and Related Studies><Bacteria><Bile Acids><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Causality><Cecum><Chemicals><Colitis><Colon><Communication><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Data><Development><Development Plans><Development and Research><Disease><Disorder><E coli><E. coli><Engineering><Enzyme Gene><Enzymes><Escherichia coli><Etiology><Experimental Designs><Fluorescence Activated Cell Sorting Fractionation><Fluorescence-Activated Cell Sorting><Fluorescence-Activated Cell Sortings><GI microbiome><GI microbiota><Gastrointestinal microbiota><Goals><Histologic><Histologically><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immune><Immune response><Immune system><Immunes><Immunomodulation><Immunosuppressants><Immunosuppressive Agents><Immunosuppressive drug><Immunosuppressive treatment><In Vitro><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Intestinal><Intestines><Investigators><Knowledge><Lactobacillus><Lamina Propria><Link><Measures><Mediating><Mentorship><Mice><Mice Mammals><Microbe><Modeling><Murine><Mus><Outcome Study><Pathogenesis><Patients><Phylogenetic Analysis><Phylogenetics><Population><Production><Public Health><R & D><R&D><Receptor Protein><Research><Research Personnel><Researchers><Scientist><Series><Severities><Signaling Molecule><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Testing><Training><adulthood><amidation><aminoacid><bile salts><bowel><career development><career fair><career networking><causation><colitis-induced dysbiosis><commensal flora><commensal microbes><commensal microbiota><commensal microflora><developmental><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><digestive tract microbiome><disease causation><enteric microbial community><enteric microbiome><enteric microbiota><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbiome><host response><immune modulation><immune regulation><immune suppressive agent><immune suppressor><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><immunosuppressive substance><immunosuppressor><in vivo><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><insight><intestinal autoinflammation><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><manage symptom><meeting><meetings><metabolism measurement><metabolomics><metabonomics><microbial><microbial consortia><microbial flora><microbiome><microbiota><microflora><model of animal><multispecies consortia><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><overexpress><overexpression><preference><professional networking><protective effect><receptor><research and development><skill acquisition><skill development><speed networking><symptom management><thymus derived lymphocyte><tool><translational impact>
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Jesse Pak

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 48/100
Training-friendly
Very recent
Active award
$37,249
FY 2026

Project Title

Characterizing a Novel Toxin in Interbacterial Competition Among B. fragilis

Grant Number:

1F30AI197460-01

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2026

End Date:

5/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Bacteroides fragilis is a gram-negative intestinal commensal that comprises up to 1% of total gut bacteria. While often considered harmless, this microbe remains a leading cause of anaerobic sepsis and abdominopelvic infections. The rise of antimicrobial resistance (AMR) in B. fragil...

Research Terms

<21+ years old><Adult><Adult Human><Alanine><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antimicrobial Resistance><B fragilis><B. fragilis><Bacteroides><Bacteroides fragilis><Binding><Biochemical><Biology><Biotin><Body Tissues><Carbapenems><Carbohydrates><Cell Body><Cells><Cellular Morphology><Clinical><Clinical Medical Sciences><Clinical Medicine><Clinical Treatment><Co-Immunoprecipitations><Colon><Coloring Agents><Complement><Complement Proteins><Complex><Confocal Microscopy><Cytolysis><Development><Drug resistance><Dyes><Environment><Family><Fe element><Future><G24 protein><GI colonization><GI commensal><GI microbiome><Genetic><Genetic Risk><Genetic Screening><Genetics-Mutagenesis><Genomics><Germ-Free><Gnotobiotic><Gnotobiotics><Human><Impairment><In Vitro><Individual><Infection><Intervention><Iron><Label><Link><Lysis><Measures><Mediating><Membrane><Methods><Mice><Mice Mammals><Microbe><Microbiomics><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Mutagenesis><Mutagenesis Molecular Biology><Nature><Needles><Neonatal><Nucleotides><Nutrient><Nutritional><Ortholog><Orthologous Gene><Pathogenicity><Phenotype><Play><Predisposition><Propidium Diiodide><Propidium Iodide><Protein Secretion><Proteins><Recombinants><Research><Risk><Role><Sepsis><Specificity><Staining method><Stains><Stealing><Susceptibility><System><Testing><Theft><Time><Tissues><Toxin><Translating><Transmission><Vertical Transmission><Visualization><Vitamin H><Vitamins><Work><adulthood><antagonism><antagonist><anti-microbial><anti-microbial resistant><antimicrobial><bacteria in the gut><beta lactam hydrolase><beta-Lactamase><beta-Lactamhydrolase><carbapenem resistance><carbapenem resistant><cell morphology><clinical intervention><clinical therapy><coenzyme R><commensal bacteria in the gastrointestinal tract><commensal bacteria in the gut><commensal bacteria in the intestine><community microbes><complementation><confocal imaging><developmental><digestive tract microbiome><drug resistant><enteric commensal><enteric microbiome><fitness><gastrointestinal commensal><gastrointestinal microbiome><gastrointestinal tract colonization><gene locus><genetic locus><genomic location><genomic locus><gut bacteria><gut colonization><gut commensal><gut microbiome><gut-associated microbiome><in vivo><insight><interest><intestinal biome><intestinal colonization><intestinal commensal><intestinal microbiome><lipophilicity><member><membrane structure><microbe community><microbial community><microbial consortia><microbial flora><microbiome><microbiome research><microbiome science><microbiome studies><microbiota><microflora><microorganism community><model of animal><multispecies consortia><mutant><novel><nutritious><polymicrobial community><prevent><preventing><resistance against carbapenems><resistance mechanism><resistance to Drug><resistance to anti-microbial><resistance to carbapenem><resistant mechanism><resistant to Drug><resistant to antimicrobial><resistant to carbapenem><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transmission process><trial regimen><trial treatment><uptake><β-Lactamase>
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Benjamin Macadangdang

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$170,492
FY 2026

Project Title

Diversity generation in the gastrointestinal microbiome

Grant Number:

5K08DK138316-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/3/2024

End Date:

11/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT ABSTRACT Colonization factors that facilitate establishment in the complex and competitive environment of the gastrointestinal (GI) microbiome are still relatively unknown, but knowledge of these factors will be crucial for understanding the formation of this ecosystem and reveal novel thera...

Research Terms

<Acceleration><Adhesives><Adult-Onset Diabetes Mellitus><Advisory Committees><Anatomic Sites><Anatomic structures><Anatomy><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Award><Bacteria><Bacterial Adhesins><Bacterial Genes><Bacteroides><Binding Proteins><Bioinformatics><Bionomics><Cardiovascular Diseases><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Codon><Codon Nucleotides><Communities><Complex><Computing Methodologies><Development Plans><Diet><Disease><Disorder><Ecologic Systems><Ecological Systems><Ecology><Ecosystem><Engineering><Engraftment><Environment><Evolution><Exhibits><Funding><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Generations><Genes><Genetic><Genetics-Mutagenesis><Genome><Genotype><Gnotobiotic><Gnotobiotics><Goals><Growth><Health><Human><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intracellular Communication and Signaling><Ketosis-Resistant Diabetes Mellitus><Knowledge><Ligand Binding><Ligand Binding Protein><Ligand Binding Protein Gene><Ligands><Maintenance><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Maturity-Onset Diabetes Mellitus><Measures><Mediating><Membrane><Mentors><Microbe><Miscellaneous Antibiotic><Modern Man><Mutagenesis><Mutagenesis Molecular Biology><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nucleotides><Nutritional><Obesity><Pattern><Periplasmic Proteins><Permeability><Phenotype><Pilum><Protein Binding><Proteins><Regulation><Research><Retroelements><Role><Scientific Inquiry><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Structure><System><T2 DM><T2D><T2DM><Task Forces><Technology><Testing><Therapeutic Intervention><Tissue Growth><Training><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Variant><Variation><Virus><Work><adhesin><adiposity><adult onset diabetes><advisory team><beneficial flora><beneficial microbes><beneficial microflora><beneficial microorganism><biological signal transduction><bound protein><cardiovascular disorder><career development><community microbes><competitive atmosphere><competitive environment><computational methodology><computational methods><computer based method><computer methods><computing method><corpulence><deep sequencing><diets><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><experience><fitness><gastrointestinal microbial flora><gastrointestinal microbiome><genetic element><genome scale><genome-wide><genomewide><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><in vivo><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><intervention therapy><intestinal autoinflammation><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><ketosis resistant diabetes><maturity onset diabetes><member><membrane structure><microbe community><microbial colonization><microbial community><microbial imbalance><microbiome><microorganism community><mouse model><multidisciplinary><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><nutritious><ontogeny><pilus><polymicrobial community><programs><protein function><response><social role><structural biology><timeline><tool><type 2 DM><type II DM><type two diabetes>
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Xiao Tan

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$169,560
FY 2026

Project Title

Machine learning-based methods for the analysis of microbial glycomes and proteomes in inflammatory bowel disease.

Grant Number:

5K08DK132516-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/4/2023

End Date:

11/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Inflammatory bowel disease (IBD) affects over 1.2 million patients in the United States and causes significant morbidity and healthcare expenditures. Studies have associated the development of IBD with changes in the human gut microbiome, which together with genetic and environmental factors alter i...

Research Terms

<Affect><Algorithms><American><Automated Annotation><Bacterial Gene Products><Bacterial Gene Proteins><Bacterial Proteins><Binding><Biochemical><Biological><Biological Function><Biological Process><Biomedical Research><Carbohydrates><Catalogs><Cell Body><Cell surface><Cells><Characteristics><Chemicals><Chronic><Chronic Disease><Chronic Illness><Classification><Collection><Complex><Computing Methodologies><DNA><Data><Data Bases><Databases><Deoxyribonucleic Acid><Development><Digestive Diseases><Digestive System Diseases><Digestive System Disorders><Disease><Disorder><Environment><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Enzyme Gene><Enzymes><Esteroproteases><Evaluation><Event><Functional Metagenomics><GI microbiome><GI microbiota><GI tract disorder><Gastroenterology><Gastrointestinal microbiota><General Hospitals><General Taxonomy><Genes><Genetic><Glycans><Glycobiology><Goals><Health Expenditures><Human><Human Genetics><Immune><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Information Retrieval><Information extraction><Intestinal><Intestines><Investigation><Label><Life><Machine Learning><Massachusetts><Mediating><Medicine><Membrane><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Mentors><Metagenomics><Methods><Microbe><Modern Man><Modification><Molecular Interaction><Morbidity><Natural Language Processing><Nucleic Acids><Pathogenesis><Pathogenicity><Pathway interactions><Patients><Peptidases><Peptide Hydrolases><Performance><Physicians><Polymers><Polysaccharides><Process><Program Development><Protease Gene><Proteases><Protein Secretion><Proteinases><Proteins><Proteolytic Enzymes><Proteome><Proteomics><Regulation><Research><Scientist><Semantics><Series><Source><Speech><Structure><Surface><Surface Proteins><Systematics><Taxonomy><Techniques><Testing><Text><Training><Translations><United States><Validation><Writing><analyze microbiome><annotation schema><anti-microbial peptide><biologic><bowel><career development><catalog><chronic disorder><colitis mouse model><colitis murine model><complex data><computational annotation><computational methodology><computational methods><computational pipelines><computer annotation><computer based method><computer methods><computing method><data base><deep learning><deep learning algorithm><deep learning based neural network><deep learning method><deep learning neural network><deep learning strategy><deep neural net><deep neural network><density><design><designing><developmental><dietary><digestive disorder><digestive tract disease><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><experiment><experimental research><experimental study><experiments><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract disease><gastrointestinal tract disorder><gene product><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><health care expenditure><high dimensional data><high dimensionality><host microbe association><host microbe relationship><host response><host-microbe interactions><host-microbial interactions><host-microorganism interactions><immune system response><immunogenicity><immunoresponse><improved><in vitro Assay><in vivo><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><instructor><intestinal autoinflammation><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><large data sets><large datasets><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><machine learning based method><machine learning method><machine learning methodologies><medical college><medical expenditure><medical schools><membrane structure><metabolism measurement><metabolomics><metabonomics><metagenome><microbial><microbiome analysis><mouse colitis><multidimensional data><multidimensional datasets><murine colitis><natural language understanding><novel><pathway><polymer><polymeric><protein function><school of medicine><skills><stool sample><stool specimen><sugar><tool><translation><validation studies><validations><vector>
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Tibor Krisko

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$168,480
FY 2026

Project Title

Leveraging the Gut Microbiome to Regulate Hepatic Gluconeogenesis

Grant Number:

5K08DK129867-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract: The objective of this Mentored Clinical Scientist Career Development Award is to elucidate the underlying mechanisms by which gut microbes regulate hepatic gluconeogenesis and thereby coordinate host nutrient homeostasis in health and disease. Non-alcoholic fatty liver dise...

Research Terms

<Advisory Committees><Amino Acids><Assay><Autoregulation><Bioassay><Bioinformatics><Biological Assay><Blood Serum><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Chronic><Circulation><Cirrhosis><Citric Acid Cycle><Clinical><Complex Mixtures><D-Glucose><Data><Development Plans><Dextrose><Diet><Disease><Disorder><Drug Therapy><Engineering><Equilibrium><Feces><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gluconeogenesis><Glucose><Goals><Health><Hepatic><Hepatic Cancer><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Homeostasis><Human><Human Figure><Human Microbiome><Human body><Hyperglycemia><Hyperglycemic Mice><In Vitro><Institution><Intermediary Metabolism><Investigation><Investigators><K-Awards><K-Series Research Career Programs><Krebs Cycle><Liver><Liver Cells><MSKCC><Malignant neoplasm of liver><Memorial Sloan-Kettering Cancer Center><Mentors><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Pathway><Metabolic Processes><Metabolism><Mice><Mice Mammals><Microbe><Microbe Genome Sequencing><Microbial Genome Sequencing><Mission><Modern Man><Molecular><Murine><Mus><NAFLD><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Nutrient><Obesity><Outcome><Pathogenesis><Pathologic><Pathway interactions><Patients><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Pharmacological Treatment><Pharmacotherapy><Physiological Homeostasis><Play><Portal Vein><Portal vein structure><Process><Production><Public Health><Publishing><R-Series Research Projects><R01 Mechanism><R01 Program><Regulation><Research><Research Career Program><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Role><Scientist><Serum><Short-Chain Fatty Acids><TCA cycle><Task Forces><Testing><Therapeutic><Thesaurismosis><Transplantation><Tricarboxylic Acid Cycle><Tricarboxylic Acids><Universities><Volatile Fatty Acids><Work><adiposity><advisory team><aminoacid><balance><balance function><blood glucose regulation><career development><chronic hepatic disease><chronic hepatic disorder><chronic liver disease><chronic liver disorder><cirrhotic><corpulence><diets><digestive tract microbiome><drug intervention><drug treatment><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><euglycemia><experiment><experimental research><experimental study><experiments><full genome><gastrointestinal microbial flora><gastrointestinal microbiome><genome sequencing><glucose RA><glucose biosynthesis><glucose control><glucose homeostasis><glucose metabolism><glucose production><glucose rate of appearance><glucose regulation><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><gut-liver axis><hepatic body system><hepatic gluconeogenesis><hepatic metabolism><hepatic organ system><host microbe association><host microbe relationship><host-microbe interactions><host-microbial interactions><host-microorganism interactions><human-associated microbiome><hyperglycemic><in vivo><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><liver cancer><liver malignancy><liver metabolism><malignant liver tumor><medical college><medical schools><metabolism disorder><metabolism measurement><metabolomics><metabonomics><microbial><microbial consortia><microbial flora><microbial imbalance><microbial whole genome sequencing><microbiome><microbiota><microflora><mouse model><multispecies consortia><murine model><non-alcohol fatty liver disease><non-alcoholic fatty liver disease><non-alcoholic liver disease><nonalcoholic fatty liver disease><novel><pathway><pharmaceutical><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><programs><school of medicine><social role><stool><transplant><western diet><western-style diet><western-type diet><whole genome>
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Dustin R Long

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$166,320
FY 2026

Project Title

Targeting the Patient Microbiome for the Prevention of Surgical Site Infection in Spine Surgery

Grant Number:

5K23AR080209-05

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Surgical site infection (SSI) is a major public health problem with devastating perioperative outcomes, affecting as many as 1 in 20 patients undergoing instrumented spine surgery. Procedures such as spinal fusion comprise the largest overall category of US spending on surg...

Research Terms

<Affect><Age><Anatomic Sites><Anatomic structures><Anatomy><Anesthesiology><Anterior><Antibiotic Premedication><Antibiotic Prophylaxis><Antibiotic Therapy><Antibiotic Treatment><Antimicrobial Resistance><Award><Back><Bacteria><Bacterial Genome><Biological><Calymmatobacterium><Caring><Categories><Cefazolin><Cervical><Cessation of life><Chest><Clinical><Clinical Data><Complex><Data Set><Death><Degenerative Disorder><Development><Development Plans><Development and Research><Disease><Disorder><Disproportionate number of men><Disproportionately impacts males><Disproportionately in men><Donovania><Dorsum><Environment><Escherichia><Foundations><Future><GWA study><GWAS><Genetic><Genetic Determinism><Genomics><Goals><Hospitals><Individual><Infection><Infection prevention><Klebsiella><MRSA><Measures><Medical center><Mentors><Methicillin Resistance><Methicillin Resistant S. Aureus><Methods><Microbiology><Microbiomics><Molecular><Molecular Epidemiology><Musculoskeletal><Nasal><Nasal Passages Nose><Nose><Operative Procedures><Operative Surgical Procedures><Otomy><Outcome><Pain><Painful><Pathogenesis><Patients><Perioperative><Perioperative Care><Personalized medical approach><Powder dose form><Powders><Prevent infection><Preventative strategy><Prevention><Prevention Measures><Prevention strategy><Preventive strategy><Procedures><Prophylactic treatment><Prophylaxis><Proteus><Protocol><Protocols documentation><Public Health><R & D><R&D><Registries><Reoperation><Repeat Surgery><Research><Research Activity><Research Specimen><Resistance><Resistance to infection><Resistance to methicillin><Resistant to methicillin><Respiratory System, Nose, Nasal Passages><Risk><Risk Factors><Role><S aureus><S. aureus><Safety><Sampling><Skin><Source><Specimen><Spinal><Spinal Column><Spinal Fusion><Spinal surgery><Spine><Spine surgery><Spondylosyndeses><Staph aureus><Staphylococcus aureus><Surgical><Surgical Interventions><Surgical Procedure><Surgical Wound Infection><Surgical incisions><Techniques><Thorace><Thoracic><Thorax><Training><Translational Research><Translational Science><Trauma><Vancomycin><Vertebral column><Woman><Work><Wound Infection><ages><anti-microbial resistant><backbone><bacterial disease treatment><bacterial genetics><bacterial infectious disease treatment><biologic><biomedical referral center><career><career development><clinical risk><clinically actionable><commensal bacteria><commensal bacterial species><cost><cutaneous microbiome><degenerative condition><degenerative disease><dermal microbiome><developmental><disability><disproportionately affects males><disproportionately affects men><disproportionately concentrated among men><disproportionately distributed among men><disproportionately higher among men><disproportionately impacts men><disproportionately occurs in men><epidermal microbiome><fecal microbiome><functional outcomes><genetic determinant><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><high risk><hospital re-admission><hospital readmission><improved><incision><individualized approach><infected wound><infection rate><infection resistance><instrument><instrumentation><male bias><male predominance><malleable risk><men disproportionately diagnosed><men disproportionately experience><men experience disproportionate rates><methicillin resistance Staphylococcus aureus><methicillin resistant><methicillin resistant Staphylococcus aureus><methicillin resistant strains of Staphylococcus aureus><microbiome><microbiome research><microbiome science><microbiome studies><modifiable risk><molecular biomarker><molecular marker><nasal microbiome><neoplastic><novel><pathogen><patient population><personalized approach><precision approach><predominantly affecting men><preservation><prospective><rate of infection><re-admission><re-hospitalization><readmission><referral center><rehospitalization><research and development><resistance to anti-microbial><resistant><resistant to antimicrobial><screening><screenings><sex><sinonasal microbiome><skin biome><skin microbiome><social role><stool microbiome><stool-associated microbiome><surgery><surgery risk><surgical risk><surgical site infection><tailored approach><tissue wound><tool><trait><translation research><translational investigation><whole genome association analysis><whole genome association study><wound><wounding><wounds>
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Catherine Elizabeth Oldenburg

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 42/100
Likely hiring
Active award
$146,513
FY 2026

Project Title

Azithromycin as adjunctive treatment for uncomplicated severe acute malnutrition: the AMOUR trial

Grant Number:

3R01HD111532-03S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/8/2023

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Amoxicillin is recommended by the World Health Organization (WHO) as adjunctive therapy for the treatment of uncomplicated severe acute malnutrition (SAM). Because children with uncomplicated SAM may have asymptomatic infection due to immune suppression, presumptive treatmen...

Research Terms

<0-11 years old><1 year of age><1 year old><6 year old><6 years of age><Active Follow-up><Acute><Africa South of the Sahara><Amoxicillin><Amoxicilline><Amoxil><Amoxycillin><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Area><Azadose><Azithromycin><Azitrocin><Azythromycin><Burkina Faso><Burkina Fasso><Campylobacter><Causality><Cessation of life><Child><Child Care><Child Mortality><Child Youth><Children (0-21)><Clinical><Co-Trimoxazole><Communities><Cotrimoxazole><Data><Death><Dose><Enrollment><Equipoise><Etiology><Evaluation><GI microbiome><Genetic><Government><Guidelines><Half-Life><Health Care Facility><Health Facilities><Hydroxyampicillin><Immune system><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Incidence><Individual><Infant><Infection><Malawi><Malnutrition><Miscellaneous Antibiotic><Morbidity><NICHD><National Institute of Child Health and Human Development><Niger><Nutritional><Nutritional Deficiency><Nyasaland><Oral><Out-patients><Outcome><Outpatients><Participant><Persons><Placebos><Policies><Polymox><Population><Primary Health Care><Probability><Protocol><Protocols documentation><Puericulture><Randomization trial><Randomized><Randomized, Controlled Trials><Recommendation><Recovery><Resistance to antibiotics><Resistant to antibiotics><Role><Running><Sampling><Sham Treatment><Sub-Saharan Africa><Subgroup><Subsaharan Africa><Tanzania><Trimox><Ultreon><Undernutrition><Upper Volta><Utimox><Weight><Weight Gain><Weight Increase><World Health Organization><Wymox><Zithromax><Zitromax><active followup><age 1><age 1 year><age 6><age 6 years><aged 1 year><aged one year><antibiotic drug resistance><antibiotic resistant><bacteria pathogen><bacterial disease treatment><bacterial infectious disease treatment><bacterial pathogen><body weight gain><body weight increase><care facilities><causation><death risk><determine efficacy><dietary deficiency><digestive tract microbiome><disease causation><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><enroll><enteric microbiome><evaluate efficacy><evidence base><examine efficacy><follow up><follow-up><followed up><followup><gastrointestinal microbiome><gut dysbiosis><gut microbiome><gut-associated microbiome><hospital re-admission><hospital readmission><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved outcome><infection risk><insight><intestinal biome><intestinal microbiome><kids><malnourished><mortality><mortality risk><nutrition deficiency><nutrition deficiency disorder><nutritional deficiency disorder><nutritious><one year of age><one year old><pathogenic bacteria><peer><population based><prevent><prevent relapse><preventing><programs><randomisation><randomization><randomized control trial><randomized placebo control trial><randomized placebo controlled trial><randomized trial><randomly assigned><re-admission><re-hospitalization><readmission><recruit><rehospitalization><relapse prevention><resistome><routine care><screening><screenings><sham therapy><six year old><six years of age><social role><treatment guidelines><weights><wt gain><youngster>
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John Ganley

PRINCETON UNIVERSITY, Princeton, NJ

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$137,484
FY 2026

Project Title

Leveraging Ecological Interactions to Unearth Cryptic Metabolites and Regulatory Pathways from Algal and Plant Microbiomes

Grant Number:

1K99GM159067-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Bacterial natural products are essential for various industries, particularly those essential for human health. However, bacteria only synthesize a small portion of their metabolome under typical laboratory conditions due to the absence of environmental triggers that activate their ...

Research Terms

<2-Phenyl-Benzopyrans><2-Phenyl-Chromenes><Advisory Committees><Agriculture><Algae><Anabolism><Arabidopsis><Arthrobacter><Assay><Automobile Driving><Award><Bacteria><Bacterial Genome><Bacterial natural products><Bacterial-derived natural product><Bioassay><Bioinformatics><Biological><Biological Assay><Bionomics><Biotech><Biotechnology><Ceramides><Chemical Structure><Chemicals><Communicable Diseases><Communication><Cues><Custom><Drug Industry><Ecology><Engineering><Environment><Finding natural products><Flavonoids><Foundations><Future><Gene Cluster><Health><Human><Hybrids><Industry><Infectious Diseases><Infectious Disorder><Intermediary Metabolism><Laboratories><Libraries><Link><Lipids><Mediating><Metabolic><Metabolic Processes><Metabolism><Methods><Microbe><Microbiomics><Modern Man><Molecular><Names><Natural Products><Natural Products Chemistry><Natural product discovery><Natural products from bacteria><Organism><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Pathway interactions><Pharmaceutic Industry><Pharmaceutical Agent><Pharmaceutical Industry><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Plant Roots><Plant derived metabolites><Plants><Postdoc><Postdoctoral Fellow><Process><Production><Protein Biochemistry><Protein/Amino Acid Biochemistry><Regulation><Regulatory Pathway><Reporter><Research><Research Associate><Research Proposals><Respiration><Role><Science><Secondary to><Stress><Structure><Symbiosis><System><Task Forces><Testing><Training><Work><advisory team><anti-microbial><antimicrobial><biologic><biological adaptation to stress><biosynthesis><career><commensalism><customs><cytotoxic><driving><drug candidate><drug discovery><experience><experiment><experimental research><experimental study><experiments><host microbe association><host microbe relationship><host-microbe interactions><host-microbial interactions><host-microorganism interactions><insight><living system><marine><marine environment><metabolome><metabonome><microbial><microbiome><microbiome research><microbiome science><microbiome studies><myricetin><name><named><naming><naturally occurring product><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><pharmaceutical><plant metabolites><post-doc><post-doctoral><post-doctoral trainee><reactioncrisis><research associates><respiratory><respiratory mechanism><scaffold><scaffolding><screening><screenings><secondary metabolite><skills><social role><stress response><stressreaction><symbiont>
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Samaneh Farsijani

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$125,928
FY 2026

Project Title

The relationship between protein intake, gut microbiome, inflammaging and loss of mobility in older adults

Grant Number:

5K01AG071855-05

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/15/2022

End Date:

11/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

This K01 application is for Dr. Samaneh Farsijani to establish a research career in Nutritional Epidemiology and acquire skills to integrate omics (gut microbiome) and non-omics (dietary intake) data towards her long-term goal in “Precision Nutrition” to develop age-specific dietary recommendations,...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Address><Adopted><Aging><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BMI><BMI percentile><BMI z-score><BSF-2><BSF2><Biology><Biometrics><Biometry><Biostatistics><Blood Plasma><Blood Serum><Body Composition><Body Weight><Body mass index><C-reactive protein><Chronic><Clinical Research><Clinical Study><Communities><Compensation><Data><Decline in mobility><Decrease in mobility><Decreased mobility><Diet><Dietary Epidemiology><Dietary Proteins><Dietary intake><Diminished mobility><Eligibility><Eligibility Determination><Epidemiology><Food><Functional impairment><GI microbiome><GI microbiota><Gait speed><Gastrointestinal microbiota><Goals><HPGF><Health><Health Policy><Hepatocyte-Stimulating Factor><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immunoassay><Inflammaging><Inflammation><Inflammatory><Interdisciplinary Research><Interdisciplinary Study><Interleukin-6><Knowledge><Link><Long-Term Effects><MGI-2><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Mediating><Mediation><Mediator><Mobility decline><Mobility disability><Mobility impairment><Multidisciplinary Collaboration><Multidisciplinary Research><Muscle><Muscle Proteins><Muscle Tissue><Muscle function><Myeloid Differentiation-Inducing Protein><Negotiating><Negotiation><Nutrition><Nutrition Research><Nutritional Study><Observational Study><Older Population><Outcome><Outcome Study><Participant><Patient Self-Report><Pattern><Physical Function><Plants><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Play><Pragmatic clinical trial><Prevention><Principal Investigator><Probabilistic Models><Probability Models><Production><Protein Biosynthesis><Proteins><Proteins, specific or class, C-reactive><Protocol Screening><Public Health><Quetelet index><Randomized><Recommendation><Recommended Dietary Allowance><Reduced mobility><Reduction in mobility><Regression Analyses><Regression Analysis><Regression Diagnostics><Research><Resistance><Reticuloendothelial System, Serum, Plasma><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Risk><Risk Reduction><Role><Sampling><Self-Report><Serum><Shapes><Source><Statistical Models><Statistical Regression><Training><Walking><Woman><absorption><age associated><age associated muscle atrophy><age correlated><age dependent><age linked><age related><age specific><age-associated decline in muscle><age-associated muscle decline><age-associated muscle deterioration><age-associated muscle loss><age-associated muscle wasting><age-related decline in muscle><age-related inflammation><age-related muscle decline><age-related muscle deterioration><age-related muscle loss><age-related muscle wasting><aging associated inflammation><aging prevention><ameliorating inflammaging><anti aging><anti geronic><anti-inflammaging><antiaging><attenuate inflammaging><bowel inflammation><career><career development><cohort><decrease disability><decrease in disability><dietary><dietary guidelines><diets><digestive tract microbiome><disability reduction><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><epidemiologic><epidemiological><frailty><functional loss><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut dysbiosis><gut flora><gut health><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><health care policy><health data><healthy aging><healthy human aging><improved><improved mobility><inflamed bowel><inflamed gut><inflamed intestine><inflamm-ageing><inflamm-aging><inflammaging mitigation><inflammation associated with aging><inflammation marker><inflammatory marker><insight><interferon beta 2><intestinal biome><intestinal flora><intestinal inflammation><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><lessen disability><men><microbial><microbial composition><microbial imbalance><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><minimize disability><mitigate age related inflammation><mitigate disability><mobility enhancement><mobility improvement><muscle bulk><muscle form><muscle mass><muscular><nutritional epidemiology><nutritional guideline><observational research study><observational survey><older adult><older adulthood><older groups><older individuals><older person><optimized mobility><precision nutrition><prevent age related><prevent age related inflammation><prevent aging><prevent inflammaging><protein distribution><protein intake><protein metabolism><protein synthesis><randomisation><randomization><randomly assigned><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing age related inflammation><reducing risk><reducing the risk><reduction in disability><resistant><response><risk-reducing><skill acquisition><skill development><skills><slow disability><social role><statistical linear mixed models><statistical linear models><suppress aging><walking pace><walking speed>
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Lynn El Haddad

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$105,792
FY 2026

Project Title

Bacteriophages as Modulators of Bacterial Colonization

Grant Number:

7K01AI166096-05

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2025

End Date:

11/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Multidrug-resistant organisms (MDROs) remain major causes of morbidity and mortality in hematopoietic cell transplant (HCT) recipients. Because of the substantial use of antibiotics in these patients, their gut microbiome balance is perturbed and becomes dominated by MDROs, vancomyci...

Research Terms

<Address><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Applied Research><Applied Science><Bacteremia><Bacteria><Bacterial Infections><Bacteriophages><Bioinformatics><Biometrics><Biometry><Biostatistics><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Bone Marrow><Bone Marrow Reticuloendothelial System><Buffers><Caudovirales><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Clinical Data><Communicable Diseases><Data><Development><Environment><Equilibrium><Evaluation><Fatal Outcome><Feces><Future><GI colonization><GI microbiome><GI microbiota><Gastrointestinal microbiota><Germ-Free><Goals><GvHD><HSC transplantation><Health><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Homologous Wasting Disease><Human><Immune response><Immune system><Incidence><Individual><Infection><Infectious Diseases><Infectious Disorder><Inflammation><Inflammatory Response><Intervention><Investigators><Knowledge><Larva><MDR organism><MDR pathogen><Malignant Hematologic Neoplasm><Mice><Mice Mammals><Microviridae><Microvirus><Miscellaneous Antibiotic><Mission><Modeling><Modern Man><Monitor><Morbidity><Murine><Mus><NIAID><NIH><National Institute of Allergy and Infectious Disease><National Institutes of Health><Outcome><Pathology><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phages><Population><Public Health><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><RAG-1 Genes><RAG1 gene><Randomized><Recombination-Activating Genes-1><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Proposals><Researchers><Risk><Role><Runt Disease><Safety><Sampling><Scheme><Sterility><Testing><Therapeutic><Time><Training><Translating><Transplant Recipients><Transplantation><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><United States National Institutes of Health><Vancomycin resistant enterococcus><Vancomycin-resistant enterococci><Virus><Wild Type Mouse><Work><World Health Organization><analyze microbiome><anti-microbial><antimicrobial><bacteraemia><bacteria infection><bacterial bloodstream infection><bacterial disease><bacterial infection in the bloodstream><bacterial microbiome><bacterial virus><bacteriome><balance><balance function><biomarker identification><blood infection><blood stem cell transplantation><bloodstream infection><career><chemotherapy><cytokine><design><designing><developmental><digestive tract microbiome><efficacy testing><enteric microbial community><enteric microbiome><enteric microbiota><experience><experiment><experimental research><experimental study><experiments><fecal sample><fighting><gastrointestinal><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><germ free condition><graft versus host disease><graft vs host disease><graft vs. host disease><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><host microbe association><host microbe relationship><host response><host-microbe interactions><host-microbial interactions><host-microorganism interactions><hypoimmunity><identification of biomarkers><identification of new biomarkers><immune deficiency><immune system response><immunodeficiency><immunoresponse><improved><improved outcome><in vivo><in vivo Model><infection in the blood><infection of the blood><infectious disease model><innovate><innovation><innovative><insight><intestinal biome><intestinal colonization><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><marker identification><microbiome><microbiome analysis><mortality><mouse model><multi-drug resistant organism><multi-drug resistant pathogen><multidrug resistant organism><multidrug resistant pathogen><multiple drug resistant organism><multiple drug resistant pathogen><murine model><normal flora><normal microbial flora><normal microbiota><normal microflora><pathogen><patient oriented outcomes><prevent><preventing><randomisation><randomization><randomly assigned><reconstitute><reconstitution><restoration><risk mitigation><skill acquisition><skill development><social role><specific pathogen free><sterile><stool><stool sample><stool specimen><synergism><transplant><transplant patient><vancomycin resistance enterococci><vancomycin resistance in enterococci><wildtype mouse>
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Conor James McMeniman

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 42/100
Likely hiring
Active award
$103,760
FY 2026

Project Title

Chemosensory Mechanisms Driving Malaria Transmission

Grant Number:

3R01AI182234-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/1/2025

End Date:

10/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

To hunt humans and transmit malaria parasites, the African malaria mosquito Anopheles gambiae relies on its sense of smell to track volatile organic compounds emitted by the human body. Human body odor comprises a complex blend of hundreds of airborne chemicals derived from our primary metabolism re...

Research Terms

<Africa South of the Sahara><African><Alcohol Chemical Class><Alcohols><Aldehydes><Alkanes><Anopheles><Anopheles Genus><Anopheles gambiae><Anophelines><Assay><Automobile Driving><Behavior><Bioassay><Biological><Biological Assay><Biological Markers><Bite><Body Temperature><Body part><CO2><Carbon Dioxide><Carbonic Anhydride><Carboxylic Acids><Chemicals><Chemistry><Complex><Cues><Culicidae><Development><Disease Vectors><Engineering><Epidemiology><Esters><Exposure to><Female><Formulation><Functional Metagenomics><Goals><Grant><Heterogeneity><Human><Human Figure><Human Microbiome><Human body><Individual><Infrastructure><Intermediary Metabolism><Ketones><Knowledge><Lactic acid><Length><Malaria><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Metagenomics><Methods><Microbe><Modern Man><Mosquito Control><Mosquito-borne disease><Mosquito-borne infectious disease><Mosquitoes><Motion><Mouth microbiome><Northern Rhodesia><Odors><Olfaction><Paludism><Parasites><Participant><Pathway interactions><Persons><Plasmodium Infections><Population Control><Population Surveillance><Process><Province><Public Health><Public Health Surveillance><Research><Resolution><Reverse engineering><Risk><Role><Sampling><Seasons><Sensory><Series><Shapes><Sight><Site><Skin><Sleep><Smell><Smell Perception><Sub-Saharan Africa><Subsaharan Africa><Supplementation><Survey Instrument><Surveys><Swab><System><Testing><Transmission><Variant><Variation><Vision><Volatilization><Zambia><bio-markers><biologic><biologic marker><biomarker><biomarker identification><candidate identification><cohort><combat><community living><community microbes><comparative><cutaneous microbiome><dermal microbiome><developmental><driving><epidemiologic><epidemiological><epidermal microbiome><human subject><human-associated microbiome><identification of biomarkers><identification of new biomarkers><improved><insight><inter-individual variability><inter-individual variation><malaria mosquito><malaria transmission><marker identification><microbe community><microbial><microbial community><microbiome><microbiome community><microorganism community><multi-modality><multimodality><nasal microbiome><novel><odor perception><olfactory perception><oral microbiome><pathway><polymicrobial community><preference><prevent><preventing><recruit><resolutions><secondary metabolite><sensory mechanism><sinonasal microbiome><skin biome><skin microbiome><social role><synergism><translation strategy><translational approach><translational strategy><transmission process><vector><visual function><volatile organic chemical><volatile organic compound><♀>
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Rahul Suresh Shinde

WISTAR INSTITUTE, PHILADELPHIA, PA

Exploratory lead · 40/100
Above-average budget
Recent
Active award
$566,752
FY 2026

Project Title

Characterizing the sources, mechanisms, and translational relevance of microbial TMAO in driving anti-tumor immunity in pancreatic cancer.

Grant Number:

5R37CA280869-03

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/6/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The treatment of pancreatic ductal adenocarcinoma (PDAC) remains a major hurdle with 5-year survival of 12%. PDAC resistance to chemotherapy and immunotherapy is thought to arise from the immunosuppressive tumor microenvironment (TME), characterized by a fibrotic stroma and high infi...

Research Terms

<Amines><Antitumor Response><Automobile Driving><Bacteria><Basal Transcription Factor><Basal transcription factor genes><Betaine><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cancer Patient><Cancer Treatment><Cancers><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><ChIP Sequencing><ChIP-seq><ChIPseq><Choline><Clinical><Data><Development><Diet><Dose><E coli><E. coli><Engineering><Enterococcus><Escherichia coli><GEM model><GEMM model><GI microbiome><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Transcription><Genetically Engineered Mouse><Goals><IFN><Immune><Immune mediated therapy><Immunes><Immuno-Chemotherapy><Immunochemotherapy><Immunologically Directed Therapy><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunotherapy><Infiltration><Interferons><Intracellular Communication and Signaling><L Carnitine><Levocarnitine><Lycine><Macrophage><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant neoplasm of pancreas><Mice><Mice Mammals><Microbe><Modeling><Murine><Mus><Mφ><Organoids><Oxides><Oxyneurine><PD-1 antibody><PD1 antibody><PDA model><PDAC Model><Pancreas Cancer><Pancreas Ductal Adenocarcinoma><Pancreatic Cancer><Pancreatic Ductal Adenocarcinoma><Patients><Phenotype><Pre-Clinical Model><Preclinical Models><Publishing><RNA Expression><Research><Resistance><STAT1><STAT1 gene><STAT3><STAT3 gene><STAT91><STING agonists><Series><Shapes><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Source><Streptococcus enterococcus group><Subcellular Process><T cell response><T8 Cells><T8 Lymphocytes><Teff cell><Testing><Toxic effect><Toxicities><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Burden><Tumor Immunity><Tumor Load><Tumor-associated macrophages><Vitamin B T><Work><aPD-1><aPD1><amine><anti programmed cell death 1><anti-PD-1><anti-PD-1 Ab><anti-PD-1 antibodies><anti-PD-1 monoclonal antibodies><anti-PD1><anti-PD1 Ab><anti-PD1 antibodies><anti-PD1 monoclonal antibodies><anti-cancer therapy><anti-programmed cell death protein 1><anti-programmed cell death protein 1 antibodies><anti-programmed death-1 antibody><anti-tumor effect><anti-tumor immune response><anti-tumor immunity><anti-tumor response><antiPD-1><antitumor effect><antitumor immunity><biological signal transduction><cancer immunity><cancer microenvironment><cancer therapy><cancer-directed therapy><check point blockade><checkpoint blockade><chemo-immuno therapy><chemoimmunotherapy><chemotherapy><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><clinical relevance><clinically relevant><developmental><dietary><diets><digestive tract microbiome><driving><effector T cell><efficacy testing><enteric microbiome><exhaustion><gastrointestinal microbiome><genetically engineered mouse model><genetically engineered murine model><gut microbes><gut microbial species><gut microbiome><gut-associated microbiome><immune check point blockade><immune checkpoint blockade><immune microenvironment><immune suppression><immune suppressive activity><immune suppressive function><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunosuppressive activity><immunosuppressive function><immunosuppressive microenvironment><immunosuppressive response><immunosuppressive tumor microenvironment><improved><intestinal biome><intestinal microbes><intestinal microbiome><intraperitoneal><malignancy><metabolism measurement><metabolomics><metabonomics><microbial><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><neoplasm/cancer><novel><pancreatic ductal adenocarcinoma model><pancreatic malignancy><programs><resistant><response><response to therapy><response to treatment><therapeutic response><therapy response><transcription factor><treatment response><treatment responsiveness><treatment strategy><tumor><tumor growth><tumor immune microenvironment><tumor microenvironment><tumor-immune system interactions><αPD-1><αPD1>
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KERWYN C. HUANG

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$434,090
FY 2026

Project Title

The impact of low-abundance commensals on gut colonization resistance

Grant Number:

1R21AI196913-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Clostridioides difficile infection (CDI) poses a significant public health burden, with approximately half a million cases annually in the United States and recurrence rates of up to 25%. CDI is primarily driven by disruptions to the gut microbiome, often due to antibiotic treatment,...

Research Terms

<Address><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Assay><Bioassay><Biological Assay><Bionomics><C diff><C difficile><C. diff><C. difficile><Chlolincocin><Chlorlincocin><Classification><Clindamycin><Clostridioides difficile><Clostridium difficile><Communities><Complex><Data><Disease><Disorder><Dropout><Ecologic Systems><Ecological Systems><Ecology><Ecosystem><Engineering><Environment><Exclusion><Failure><Foundations><GI colonization><GI commensal><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genomics><Germ-Free><Gnotobiotic><Gnotobiotics><Health><Health Care><High Throughput Assay><Human><In Vitro><Infection><Insurance><Invaded><Knowledge><Maps><Measures><Metabolic><Methodology><Methods><Mice><Mice Mammals><Microbe><Miscellaneous Antibiotic><Modeling><Modern Man><Murine><Mus><Outcomes Research><Phenotype><Play><Process><Property><Public Health><Recovery><Recurrence><Recurrent><Reproducibility><Research><Resistance><Resolution><Role><Safety><Serial Passage><Structure><Systematics><Testing><Therapeutic><United States><Work><bacterial disease treatment><bacterial infectious disease treatment><clinical applicability><clinical application><colonization resistance><combat><commensal bacteria in the gastrointestinal tract><commensal bacteria in the gut><commensal bacteria in the intestine><community microbes><cost><design><designing><digestive tract microbiome><empowerment><enteral infection><enteral pathogen><enteric commensal><enteric infection><enteric microbial community><enteric microbiome><enteric microbiota><enteric pathogen><enteric pathogen infection><enteropathogen><enteropathogen infection><enteropathogenic infection><experiment><experimental research><experimental study><experiments><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal sample><fecal transplant><fecal transplantation><feeding><flexibility><flexible><gastrointestinal commensal><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><gut colonization><gut commensal><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><high throughput screening><in vivo><infected with enteropathogen><infection recurrence><innovate><innovation><innovative><insight><intestinal biome><intestinal colonization><intestinal commensal><intestinal flora><intestinal infection><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal pathogen><intestinal tract microflora><intestine infection><intestine pathogen><member><metabolism measurement><metabolomics><metabonomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><microorganism community><mouse model><multispecies consortia><murine model><next generation><pathogen><polymicrobial community><prevent><preventing><rational design><recurrent infection><recurring infection><resilience><resilient><resistant><resolutions><social role><stem><stool sample><stool specimen><tool>
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Guillaume Urtecho

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$428,855
FY 2026

Project Title

Integrative Computational and Experimental Approaches to Assess Metabolic Complementarity for Precision Microbiota Transplantation Therapies

Grant Number:

1R21AT013617-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT The gut microbiome is a cornerstone of host health, shaping immune responses, metabolism, and resilience to disease. However, attempts to treat dysbiosis via fecal microbiota transplantation (FMT) are frequently limited by colonization resistance, where resident microbes inhibit new strains...

Research Terms

<Address><Affect><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Bacteria><Biochemical><Bypass><Clinical Research><Clinical Study><Communities><Complement><Complement Proteins><Complementary intervention><Complementary therapies><Complementary treatment><Complex><Data><Data Set><Diathesis><Disease><Disease susceptibility><Disorder><Donor Screening><Donor Selection><Ecologic Systems><Ecological Systems><Ecosystem><Engraftment><Environment><Feces><Foundations><Functional Metagenomics><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Growth><Health><Human><Immune response><Immunomodulation><In Vitro><Individual><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intermediary Metabolism><Intervention><Invaded><Knowledge><Link><Metabolic><Metabolic Processes><Metabolic syndrome><Metabolism><Metagenomics><Methods><Mice><Mice Mammals><Microbe><Miscellaneous Antibiotic><Mission><Modeling><Modern Man><Molecular><Murine><Mus><NCCAM><NCCIH><National Center for Complementary and Integrative Health><National Center for Complementary and Integrative Medicine><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Obesity><Outcome><Pathway interactions><Phenotype><Regimen><Research Resources><Resources><Sampling><Shapes><Therapeutic><Time><Tissue Growth><Training><Transplant Recipients><Transplantation><Treatment Efficacy><Work><adiposity><assess effectiveness><candidate identification><clinical applicability><clinical application><cohort><colonization resistance><community microbes><complementation><computational framework><computer framework><corpulence><design><designing><determine effectiveness><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><effectiveness assessment><effectiveness evaluation><enteric microbial community><enteric microbiome><enteric microbiota><evaluate effectiveness><examine effectiveness><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbial flora><gastrointestinal microbiome><genome scale><genome-wide><genomewide><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbiota><host microflora><host response><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><intervention efficacy><intestinal autoinflammation><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><liability to disease><metabolic profile><metagenome sequencing><metagenomic sequencing><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome transplant><microbiome transplantation><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microbiota transplant><microbiota transplantation><microflora><microorganism community><multispecies consortia><next generation><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><novel><ontogeny><pathway><patient variability><patient variation><polymicrobial community><prevent><preventing><resident microbes><resident microflora><resilience><resilient><stool><therapeutic efficacy><therapy efficacy><translational impact><transplant><transplant patient><transplant therapy><transplant treatment><transplantation therapy><transplantation treatment><variability between patients><variation between patients><whole health><whole person health>
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Samuel Lai

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$427,625
FY 2026

Project Title

Phage-mediated in situ reprogramming of the complex human IBD gut microbiome for suppressing chronic inflammation in murine experimental colitis

Grant Number:

1R21AI197116-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/17/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

An imbalance in the gut microbiome (i.e. dysbiosis) is broadly implicated in the chronic inflammation leading to Inflammatory Bowel Diseases (IBD). Naturally, the gut microbiome holds promise as a therapeutic target, yet it remains under-exploited due to limited tools available to precisely modify t...

Research Terms

<(TNF)-α><Abdominal Pain><Abscess><Affect><Alimentary Canal><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Assay><Bacteria><Bacteriophage T7><Bacteriophages><Benchmarking><Best Practice Analysis><Bioassay><Biological Agent><Biological Assay><Biological Products><Biological Response Modifier Therapy><Biological Therapy><Bleeding><Blinded><Blood Serum><Bodily secretions><Body Weight decreased><Cachectin><Categories><Cell Body><Cells><Characteristics><Chronic><Chronic diarrhea><Clinical><Clinical Treatment Moab><Coliphage T7><Colitis><Complex><Cytolysis><DNA><DNA Replication><DNA Synthesis><DNA Therapy><DNA biosynthesis><Deoxyribonucleic Acid><Development><Digestive Tract><Distal><Dosage Forms><Dose><Drugs><E coli><E. coli><ELISA><Edodekin Alfa><Electron Microscopy><Engineering><Engraftment><Enterobacteria phage T7><Enzyme Gene><Enzyme-Linked Immunosorbent Assay><Enzymes><Escherichia coli><Exonuclease><Feces><Flare><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Formulation><Foundations><GI Tract><GI microbiome><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Transfer Clinical><Generations><Genetic><Genetic Intervention><Genomics><Goblet Cells><Hemorrhage><Histologic><Histologically><Horizontal Gene Transfer><Human><Hyperplasia><Hyperplastic><IL-12><IL-23><IL12><In Situ><In Vitro><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Injections><Interleukin-12><Intestinal><Intestines><Investigators><Lateral Gene Transfer><Leucocytic infiltrate><Liver><Local Therapy><Localized Therapy><Lysis><Lysogeny><Macrophage-Derived TNF><Mediating><Medication><Mice><Mice Mammals><Modeling><Modern Man><Modification><Monitor><Monoclonal Antibodies><Monocyte-Derived TNF><Morphology><Murine><Mus><NKSF><Natural Killer Cell Stimulatory Factor><Operative Procedures><Operative Surgical Procedures><Operon><Oral><Persons><Phages><Pharmaceutical Preparations><Probiotics><Prophage Integration><QOL improvement><Rectum><Reporter><Research><Research Personnel><Researchers><Risk><S marcescens><S. marcescens><Safety><Serratia marcescens><Serum><Severities><Shigella><Site><Surgical><Surgical Interventions><Surgical Procedure><T3SS><T7 Phage><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Therapeutic><Toxic effect><Toxicities><Transgenes><Transgenic Organisms><Treatment Efficacy><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Type III Secretion System><Type III Secretion System Pathway><VHH><VHH antibody><Vaccines><Viral Vector><Weight Loss><Weight Reduction><Work><alimentary tract><bacteria in the gut><bacteria vector><bacterial vector><bacterial virus><benchmark><biological therapeutic><biological treatment><biologically based therapeutics><biologics><biopharmaceutical><biotherapeutic agent><biotherapeutics><biotherapy><blood loss><body weight loss><bowel><bowel inflammation><burden of disease><burden of illness><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><cost><cost effective><cytokine><ddPCR><debilitating symptom><developmental><digestive canal><digestive tract microbiome><disease burden><droplet digital PCR><droplet digital Polymerase Chain Reaction><droplet-based digital PCR><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><enteric microbiome><enzyme linked immunoassay><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><flow cytophotometry><gastrointestinal><gastrointestinal microbiome><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><gut bacteria><gut inflammation><gut microbiome><gut-associated microbiome><hepatic body system><hepatic organ system><hospitalization rates><improved><improvements in QOL><improvements in quality of life><in vivo><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><inhibitor><interleukin-23><intervention efficacy><intestinal autoinflammation><intestinal biome><intestinal inflammation><intestinal microbiome><light scattering><mAbs><metagenome sequencing><metagenomic sequencing><microbial><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><monoclonal Abs><mouse model><multispecies consortia><murine model><nano-luciferase><nanobodies><nanobody><nanoluciferase><nanopore based sequencing><nanopore long read seq><nanopore long-read sequencing><nanopore seq><nanopore sequencing><nanopore-based long-read sequencing><new approaches><novel><novel approaches><novel strategies><novel strategy><phage vector><prebiotics><programs><quality of life improvement><response><sdAb><side effect><single domain antibodies><steroid addiction><steroid dependence><stool><success><surgery><synthetic biology><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapeutic target><therapy efficacy><tool><transduction efficiency><transgene><transgene expression><transgenic><type 3 secretion system><variable heavy chain antibody><vector><wt-loss>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ryan B Sartor

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$427,625
FY 2026

Project Title

Phage-mediated in situ reprogramming of the complex human IBD gut microbiome for suppressing chronic inflammation in murine experimental colitis

Grant Number:

1R21AI197116-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/17/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

An imbalance in the gut microbiome (i.e. dysbiosis) is broadly implicated in the chronic inflammation leading to Inflammatory Bowel Diseases (IBD). Naturally, the gut microbiome holds promise as a therapeutic target, yet it remains under-exploited due to limited tools available to precisely modify t...

Research Terms

<(TNF)-α><Abdominal Pain><Abscess><Affect><Alimentary Canal><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Assay><Bacteria><Bacteriophage T7><Bacteriophages><Benchmarking><Best Practice Analysis><Bioassay><Biological Agent><Biological Assay><Biological Products><Biological Response Modifier Therapy><Biological Therapy><Bleeding><Blinded><Blood Serum><Bodily secretions><Body Weight decreased><Cachectin><Categories><Cell Body><Cells><Characteristics><Chronic><Chronic diarrhea><Clinical><Clinical Treatment Moab><Coliphage T7><Colitis><Complex><Cytolysis><DNA><DNA Replication><DNA Synthesis><DNA Therapy><DNA biosynthesis><Deoxyribonucleic Acid><Development><Digestive Tract><Distal><Dosage Forms><Dose><Drugs><E coli><E. coli><ELISA><Edodekin Alfa><Electron Microscopy><Engineering><Engraftment><Enterobacteria phage T7><Enzyme Gene><Enzyme-Linked Immunosorbent Assay><Enzymes><Escherichia coli><Exonuclease><Feces><Flare><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Formulation><Foundations><GI Tract><GI microbiome><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Transfer Clinical><Generations><Genetic><Genetic Intervention><Genomics><Goblet Cells><Hemorrhage><Histologic><Histologically><Horizontal Gene Transfer><Human><Hyperplasia><Hyperplastic><IL-12><IL-23><IL12><In Situ><In Vitro><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Injections><Interleukin-12><Intestinal><Intestines><Investigators><Lateral Gene Transfer><Leucocytic infiltrate><Liver><Local Therapy><Localized Therapy><Lysis><Lysogeny><Macrophage-Derived TNF><Mediating><Medication><Mice><Mice Mammals><Modeling><Modern Man><Modification><Monitor><Monoclonal Antibodies><Monocyte-Derived TNF><Morphology><Murine><Mus><NKSF><Natural Killer Cell Stimulatory Factor><Operative Procedures><Operative Surgical Procedures><Operon><Oral><Persons><Phages><Pharmaceutical Preparations><Probiotics><Prophage Integration><QOL improvement><Rectum><Reporter><Research><Research Personnel><Researchers><Risk><S marcescens><S. marcescens><Safety><Serratia marcescens><Serum><Severities><Shigella><Site><Surgical><Surgical Interventions><Surgical Procedure><T3SS><T7 Phage><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Therapeutic><Toxic effect><Toxicities><Transgenes><Transgenic Organisms><Treatment Efficacy><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Type III Secretion System><Type III Secretion System Pathway><VHH><VHH antibody><Vaccines><Viral Vector><Weight Loss><Weight Reduction><Work><alimentary tract><bacteria in the gut><bacteria vector><bacterial vector><bacterial virus><benchmark><biological therapeutic><biological treatment><biologically based therapeutics><biologics><biopharmaceutical><biotherapeutic agent><biotherapeutics><biotherapy><blood loss><body weight loss><bowel><bowel inflammation><burden of disease><burden of illness><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><cost><cost effective><cytokine><ddPCR><debilitating symptom><developmental><digestive canal><digestive tract microbiome><disease burden><droplet digital PCR><droplet digital Polymerase Chain Reaction><droplet-based digital PCR><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><enteric microbiome><enzyme linked immunoassay><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><flow cytophotometry><gastrointestinal><gastrointestinal microbiome><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><gut bacteria><gut inflammation><gut microbiome><gut-associated microbiome><hepatic body system><hepatic organ system><hospitalization rates><improved><improvements in QOL><improvements in quality of life><in vivo><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><inhibitor><interleukin-23><intervention efficacy><intestinal autoinflammation><intestinal biome><intestinal inflammation><intestinal microbiome><light scattering><mAbs><metagenome sequencing><metagenomic sequencing><microbial><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><monoclonal Abs><mouse model><multispecies consortia><murine model><nano-luciferase><nanobodies><nanobody><nanoluciferase><nanopore based sequencing><nanopore long read seq><nanopore long-read sequencing><nanopore seq><nanopore sequencing><nanopore-based long-read sequencing><new approaches><novel><novel approaches><novel strategies><novel strategy><phage vector><prebiotics><programs><quality of life improvement><response><sdAb><side effect><single domain antibodies><steroid addiction><steroid dependence><stool><success><surgery><synthetic biology><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapeutic target><therapy efficacy><tool><transduction efficiency><transgene><transgene expression><transgenic><type 3 secretion system><variable heavy chain antibody><vector><wt-loss>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Johanna B. Holm

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$427,625
FY 2026

Project Title

Modeling the Vaginal Microbiome: Predicting BV Recurrence and Identifying Preventative Targets

Grant Number:

1R21AI196307-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/6/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Bacterial vaginosis (BV) is the most common form of vaginitis, affecting approximately one in three women at some point in their lives. Women with BV face serious and costly reproductive and obstetric complications, including the acquisition of sexually transmitted infections such as HIV, preterm de...

Research Terms

<AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Affect><Antibiotic Therapy><Antibiotic Treatment><Assay><Bacterial Vaginitis><Bacterial Vaginosis><Base Composition><Bioassay><Biological Assay><Cannot achieve a pregnancy><Case-Comparison Studies><Case-Compeer Studies><Case-Referent Studies><Case-Referrent Studies><Case/Control Studies><Causality><Cell Body><Cells><Classification><Clinical><Communities><Corynebacterium vaginale><Data><Data Set><Defense Mechanisms><Development><Diagnosis><Diagnostic Method><Diagnostic Procedure><Diagnostic Technique><Diagnostic tests><Difficulty conceiving><Discipline of obstetrics><Effectiveness><Elasticity><Engineering><Etiology><Event><Face><Foundations><Functional Metagenomics><Future><G vaginalis><G. vaginalis><GWA study><GWAS><Gardnerella><Gardnerella vaginalis><Gene Cluster><General Taxonomy><Genes><Genomics><Goals><Gynecologic><H vaginalis><H. vaginalis><HIV><Haemophilus vaginalis><Health><Health Expenditures><Human Immunodeficiency Viruses><In Vitro><Infection><Infertility><Intervention><Itching><LAV-HTLV-III><Lactobacillus><Lasso><Life><Link><Logistic Regressions><Longitudinal Studies><Longitudinal Surveys><Lymphadenopathy-Associated Virus><Measures><Metadata><Metagenomics><Methods><Mining><Miscarriage><Modeling><Molecular><NIH><National Institutes of Health><Nonspecific Vaginitis><Obstetrics><Odors><Ortholog><Orthologous Gene><Outcome><Pain><Painful><Participant><Pathogenesis><Pelvic Inflammatory Disease><Population><Population Attributable Risks><Premature Birth><Prematurely delivering><Preterm Birth><Prevention><Preventive><Process><Pruritic Disorder><Pruritis><Pruritus><Public Health><Recommendation><Recurrence><Recurrent><Reporting><Reproductive Health><Resolution><Risk><Sexually Transmitted Diseases><Sexually Transmitted Disorder><Sexually Transmitted Infection><Shotguns><Spontaneous abortion><Statistical Methods><Symptoms><Systematics><Taxonomy><Techniques><Therapeutic><Therapeutic Intervention><Time><Translating><United States National Institutes of Health><Urination><Vagina><Vagina Discharge><Vaginal Discharge><Vaginitis><Validation><Venereal Diseases><Venereal Disorders><Venereal Infections><Virus-HIV><Woman><Work><accurate diagnostics><attributable fraction><bacterial disease treatment><bacterial infectious disease treatment><case control><case-control survey><case-controlled><case-controlled studies><causation><co-morbid><co-morbidity><comorbidity><computer based prediction><cost><developmental><diagnostic assay><disease causation><effective therapy><effective treatment><efficacious therapy><efficacious treatment><efficacy validation><entire genome><experience><faces><facial><fertility cessation><fertility loss><full genome><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><health care expenditure><high dimensionality><improved><indexing><infertile><innovate><innovation><innovative><intervention therapy><irritation><itch sensation><long-term study><longitudinal outcome studies><longitudinal research study><machine learning based method><machine learning method><machine learning methodologies><medical expenditure><meta data><metagenome><metagenome sequencing><metagenomic sequencing><method development><microbial consortia><microbial flora><microbiota><microflora><micturition><multispecies consortia><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><non-specific vaginitis><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><obstetrical complication><pelvic inflammation disease><pelvic inflammation disorder><pelvic inflammatory disorder><pelvic inflammatory syndrome><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><predictive biological marker><predictive biomarkers><predictive marker><predictive modeling><predictive molecular biomarker><premature childbirth><premature delivery><preterm delivery><prevent><preventing><psychological defense mechanism><random forest><reproductive><resolutions><screening><screenings><self esteem><sexually acquired infection><shot gun><statistic methods><supervised learning><supervised machine learning><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><translational opportunities><translational potential><vaginal biome><vaginal flora><vaginal microbial community><vaginal microbiome><vaginal microbiota><vaginal microflora><validate efficacy><validation studies><validations><whole genome><whole genome association analysis><whole genome association study>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

KERWYN C. HUANG

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$423,500
FY 2026

Project Title

Effects of oxygen and bile acid processing on the small intestinal microbiome and colonization resistance

Grant Number:

1R21AI197001-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The small intestine (SI) is a critical site of host-microbe interactions and nutrient absorption, yet it remains severely understudied due to the difficulty of non-invasively sampling its microbiome and environment. Most microbiome studies rely on fecal samples, which primarily refle...

Research Terms

<Address><Aerobic><Alimentary Canal><Animals><Bile Acids><Bionomics><Causality><Chemicals><Collection><Colon><Communities><Data><Data Set><Development><Devices><Diathesis><Digestive Tract><Disease><Disease susceptibility><Disorder><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Earth><Ecology><Environment><Environmental Factor><Environmental Risk Factor><Enzyme Gene><Enzymes><Etiology><Exhibits><Feces><Foundations><Functional Metagenomics><GI Tract><GI colonization><GI microbiome><GI microbiota><Gastrointestinal Diseases><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Generalized Growth><Genomics><Goals><Growth><Habitats><Health><Human><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><In Vitro><Individual><Intermediary Metabolism><Irritable Bowel Syndrome><Irritable Colon><Knowledge><Laboratories><Large Intestine><Libraries><Link><Metabolic Drug Detoxications><Metabolic Processes><Metabolism><Metabolism of Toxic Agents><Metagenomics><Microbe><Microbiomics><Modeling><Modern Man><Mucous Colitis><O element><O2 element><Oxygen><Pathogenicity><Patients><Physiologic><Physiological><Physiology><Planet Earth><Play><Probiotics><Process><Research><Role><Sampling><Shapes><Site><Small Intestines><Stimulus><Structure><System><Technology><Tissue Growth><Toxic effect><Toxicities><Work><alimentary tract><anti-microbial><antimicrobial><bile acid metabolism><bile metabolism><bile salts><causation><colonization resistance><community microbes><community setting><cross immunity><cross protection><design><designing><detoxification><developmental><digestive canal><digestive tract microbiome><disease causation><enteral pathogen><enteric microbial community><enteric microbiome><enteric microbiota><enteric pathogen><enteropathogen><environmental risk><fecal sample><gastrointestinal><gastrointestinal disorder><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><gut colonization><gut community><gut flora><gut health><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><high throughput analysis><host microbe association><host microbe relationship><host-microbe interactions><host-microbial interactions><host-microorganism interactions><in vivo><inhibitor><innovate><innovation><innovative><insight><intestinal biome><intestinal colonization><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal pathogen><intestinal tract microflora><intestine pathogen><large bowel><liability to disease><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metagenome sequencing><metagenomic sequencing><microbe community><microbial><microbial community><microbial composition><microbiome><microbiome community composition><microbiome composition><microbiome intervention><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microorganism><microorganism community><new approaches><novel><novel approaches><novel strategies><novel strategy><nutrient absorption><ontogeny><pathogen><polymicrobial community><preference><pressure><probiotic therapeutic><probiotic therapy><probiotic treatment><response><small bowel><social role><spastic colon><stool><stool sample><stool specimen><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><translational applications>
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Helen Beilinson Lietuvninkas

UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 40/100
Training-friendly
Recent
Active award
$84,580
FY 2026

Project Title

The Role of Host Genetics in Shaping Intestinal Lactobacillus Population

Grant Number:

5F32AI179006-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Commensal microbes are indispensable for healthy physiology of their eukaryotic hosts and provide essential functions required for host survival, including nutrition and colonization resistance, and perform accessory functions, including immune system development, vascularization, a...

Research Terms

<0-4 weeks old><Acute><Autoimmune Status><Autoimmunity><Automobile Driving><BALB C Mouse><BALB/c><Bacteria><Basic Research><Basic Science><Behavior><Chicago><Chromosome Mapping><Complement><Complement Proteins><Computer Analysis><Correlative Study><Data><Dedications><Diet><Digestion><Dominant Genetic Conditions><Dominant trait><Environmental Factor><Environmental Risk Factor><Food><GI commensal><GI microbiome><Gene Localization><Gene Mapping><Gene Mapping Genetics><Generalized Growth><Genes><Genetic><Genetic Dominant><Genetic study><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><Growth><Health><Host Factor><Host Factor Protein><Human><Immune system><Immunologist><Immunology><Inbred BALB C Mice><Inbred Strains Mice><Individual><Infection><Innate Immune Response><Integration Host Factors><Intestinal><Intestines><Kinetics><Laboratories><Lactobacillus><Linkage Mapping><Location><Maintenance><Mentors><Mice><Mice Mammals><Microbe><Microbiology><Modeling><Modern Man><Mucous body substance><Mucus><Murine><Mus><Necrotizing Enterocolitis><Newborn Infant><Newborns><Nutrient><Nutrition><Phenotype><Physiology><Play><Population><Postdoc><Postdoctoral Fellow><Research Associate><Research Resources><Resources><Role><Shapes><Small Intestines><Systems Development><Testing><Time><Tissue Growth><Total Human and Non-Human Gene Mapping><Training><Twin Studies><Universities><Vascularization><adaptive immune response><alpha-Defensins><anti-microbial peptide><bacterial community><bowel><career><colonization resistance><commensal bacteria><commensal bacteria in the gastrointestinal tract><commensal bacteria in the gut><commensal bacteria in the intestine><commensal bacterial species><commensal community><commensal flora><commensal microbes><commensal microbiome><commensal microbiota><commensal microflora><commensal species><complementation><computational analyses><computational analysis><computer analyses><diets><digestive tract microbiome><driving><dysbacteriosis><dysbiosis><dysbiotic><enteric commensal><enteric microbiome><environmental risk><experiment><experimental research><experimental study><experiments><gastrointestinal><gastrointestinal commensal><gastrointestinal microbiome><genetic analysis><genetic mapping><gut commensal><gut dysbiosis><gut microbiome><gut-associated microbiome><host microbiome><in vivo><interdisciplinary approach><intestinal biome><intestinal commensal><intestinal microbiome><member><microbial composition><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microorganism><mouse model><mucosal site><mucous><multidisciplinary approach><murine model><newborn child><newborn children><non-human primate><nonhuman primate><ontogeny><pathogen><pathogenic virus><positional cloning><post-doc><post-doctoral><post-doctoral trainee><research associates><resident commensals><response><small bowel><social role><uptake><viral pathogen><virus pathogen><α-Defensins>
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Molly Nelson

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 40/100
Training-friendly
Recent
Active award
$49,538
FY 2026

Project Title

Early-Life Microbes Prevent Autoimmune Diabetes by Upregulating PD-1 on T Cells

Grant Number:

1F31DK143738-01A1

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary: Type 1 diabetes (T1D) is a chronic autoimmune disease that affects millions globally, and the incidence of T1D is increasing. Early-life disruptions of the gut microbiome have long-lasting impacts on the risk for developing type 1 diabetes (T1D), yet how the composition of the earl...

Research Terms

<21+ years old><Activities of Daily Living><Activities of everyday life><Address><Adult><Adult Human><Affect><Animals><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Autoimmune Diabetes><Autoimmune Diseases><Autoimmune Status><Autoimmunity><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><B9 endocrine pancreas><Bacteria><Brittle Diabetes Mellitus><Cell Communication and Signaling><Cell Locomotion><Cell Migration><Cell Movement><Cell Signaling><Cellular Migration><Cellular Motility><Childhood><Childhood diabetes><Children's Hospital><Communication><Communities><Complex><Computer Analysis><Data><Data Analyses><Data Analysis><Development><Diabetes Mellitus><Educational process of instructing><Endocrine Pancreas><Environmental Factor><Environmental Risk Factor><Experimental Designs><Fellowship><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Frequencies><Future><GI microbiome><Genetic><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><Humulin R><IDDM><Immune><Immune response><Immune system><Immunes><Immunologic Technics><Immunologic Techniques><Immunological Technics><Immunological Techniques><Immunology><Immunomodulation><In Vitro><Inbred NOD Mice><Incidence><Institution><Insulin><Insulin-Dependent Diabetes Mellitus><Intracellular Communication and Signaling><Investigation><Investigators><Islands of Langerhans><Islet Cell><Islets of Langerhans><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Laboratories><Life><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphatic nodes><Measures><Mediating><Mentors><Mentorship><Mice><Mice Mammals><Microbe><Miscellaneous Antibiotic><Modeling><Murine><Mus><NOD Mouse><Nesidioblasts><Non-Obese Diabetic Mice><Nonobese Diabetic Mouse><Novolin R><PD 1><PD-1><PD1><Pancreas><Pancreatic><Pancreatic Islets><Pars endocrina pancreatis><Pathway interactions><Patients><Pediatric Hospitals><Pennsylvania><Persons><Philadelphia><Population><Pre-DM><Prediabetes><Prediabetes syndrome><Prediabetic State><Predisposition><Receptor Protein><Regular Insulin><Research Personnel><Research Resources><Researchers><Resources><Risk><Science><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Spleen><Spleen Reticuloendothelial System><Structure><Students><Sudden-Onset Diabetes Mellitus><Susceptibility><Systems Development><T-Cells><T-Lymphocyte><T1 DM><T1 diabetes><T1D><T1DM><Teaching><Teff cell><Therapeutic><Time><Training><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Universities><Weaning><Work><Writing><adulthood><analog><autoimmune condition><autoimmune disorder><autoimmune reactivity><autoimmunity disease><autoreactive T cell><autoreactivity><biological signal transduction><career><career development><cell motility><chronic autoimmune disease><clinical relevance><clinically relevant><commensal flora><commensal microbes><commensal microbiota><commensal microflora><compare to control><comparison control><computational analyses><computational analysis><computer analyses><daily living function><daily living functionality><data interpretation><develop therapy><developmental><diabetes><diabetes during childhood><diabetes in childhood><diabetes in children><diabetes pathogenesis><digestive tract microbiome><disease risk><disorder risk><effector T cell><enteric microbiome><environmental risk><exhaust><flow cytophotometry><functional ability><functional capacity><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><high dimensionality><high risk><host response><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><improved><innovate><innovation><innovative><insulin dependent diabetes><insulin dependent type 1><intervention development><intestinal biome><intestinal microbiome><islet><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><lymph gland><lymph nodes><lymphnodes><meeting><meetings><member><microbial><microbial consortia><microbial flora><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><mouse model><multispecies consortia><murine model><non-obese diabetic (NOD) mice><nonobese diabetic (NOD) mice><novel><pathway><pediatric><pediatric diabetes><pre-diabetes><pre-diabetic><prediabetic><prevent><preventing><programmed cell death 1><programmed cell death protein 1><programmed death 1><programs><receptor><restraint><scRNA sequencing><scRNA-seq><self-reactive T cell><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><sle2><systemic lupus erythematosus susceptibility 2><therapy development><thymus derived lymphocyte><treatment development><type I diabetes><type one diabetes>
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Jenna Abusalim

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 40/100
Training-friendly
Recent
Active award
$46,138
FY 2026

Project Title

Dissecting the effect of diet on gut microbiome metabolism

Grant Number:

5F30DK139739-03

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/16/2024

End Date:

12/15/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Gut microbiome products such as indole and phenol metabolites have major impacts on host physiology. Decreased production of these important metabolites is linked with many diseases, and increasing circulating concentrations of indole or phenol metabolites ameliorates inflammatory b...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Affect><Amino Acids><Automobile Driving><Autoregulation><Bacteria><Biological Response Modifiers><Biomodulators><Blood Serum><Carbol><Carbolic Acid><Cellulose><Colon><Data><Diet><Diet Modification><Dietary Component><Dietary Fiber><Dietary Formulations><Dietary Modifications><Dietary Proteins><Dietary intake><Digestion><Disease><Disorder><Equilibrium><Feces><Fermentation><Fiber><Food Preferences><Food Processing><Foundations><GI microbiome><GI microbiota><Gastrointestinal microbiota><Goals><Gut Epithelium><Hippuric acid><Homeostasis><Hour><Hydroxybenzene><Immune Mediators><Immune Mediators/Modulators><Immune Tolerance><Immunologic Tolerance><Indoles><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Infusion><Infusion procedures><Intermediary Metabolism><Intestinal><Intestines><Inulin><Isotopes><L-Tryptophan><LC/MS><Label><Levotryptophan><Link><Measures><Mechanics><Mediating><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Mucins><Mucous body substance><Mucus><Mucus Glycoprotein><Murine><Mus><Obesity><Patients><Pectins><Phenols><Phenylalanine><Physiologic><Physiological><Physiological Homeostasis><Physiology><Polyanhydroglucuronic Acid><Process><Production><Protein Denaturation><Protein Secretion><Proteins><Route><Scheme><Serum><Small Intestines><Source><Techniques><Testing><Thick><Thickness><Tryptophan><Work><absorption><adiposity><ahr ligand><alpha-Cellulose><aminoacid><aryl hydrocarbon receptor ligand><balance><balance function><benzamidoacetic acid><benzoylglycine><bowel><cinnamic acid><cooking><corpulence><diet alteration><diet choice><diet control><diet preference><dietary><dietary alteration><dietary choice><dietary control><dietary preferences><diets><digestive tract microbiome><driving><enteric microbial community><enteric microbiome><enteric microbiota><fecal sample><feeding><food choice><gastrointestinal epithelium><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><histologic stains><histological stains><immune system tolerance><immune unresponsiveness><immunological paralysis><inflammatory disease of the intestine><inflammatory disorder of the intestine><infusions><insoluble aggregate><intestinal autoinflammation><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><liquid chromatography mass spectrometry><mechanic><mechanical><methoxy pectin><methoxylpectin><methoxypectin><microbial><microbial composition><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><mouse model><mucous><murine model><obesigenic><obesogenic><pectinic acid><protein aggregate><protein aggregation><small bowel><stool><stool sample><stool specimen><tool>
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Lucas Noah Patel

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 40/100
Training-friendly
Recent
Active award
$43,784
FY 2026

Project Title

Assessing the longitudinal impact of Mediterranean diet interventions to reduce cognitive decline on gut microbiota composition and bile acid variety

Grant Number:

1F30AG094275-01A1

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

2/2/2026

End Date:

2/1/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Alzheimer’s disease is a progressive neurodegenerative disorder with a complex etiology affecting over six million individuals in the United States alone, with numbers projected to rise significantly as the population ages. Concomitant changes in gut microbiome and metabolom...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><APOE><Adherence><Affect><Age><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's disease therapeutic><Alzheimer's therapeutic><Alzheimers Dementia><Amyloid (Aβ) plaques><Amyloid Plaques><Apo-E><ApoE protein><Apolipoprotein E><Awareness><Bile Acids><Blood Serum><Brain><Brain Nervous System><Causality><Cholesterol Homeostasis><Clinical Treatment><Clinical Trials><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complex><Computational toolkit><Control Groups><Data><Degenerative Neurologic Disorders><Development><Diagnostic><Diet><Diet Modification><Dietary Intervention><Dietary Modifications><Disease Progression><Disturbance in cognition><Encephalon><Etiology><Fats><Fatty acid glycerol esters><Functional Metagenomics><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genomics><Groups at risk><Health><Image><Impaired cognition><Individual><Inflammatory><Influentials><Intermediary Metabolism><Intervention><Intervention Studies><Investigation><Joints><Libraries><Life Style><Lifestyle><Link><Long-Term Effects><MR Imaging><MR Tomography><MRI><MRIs><Machine Learning><Magnetic Resonance Imaging><Measures><Mediating><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mediterranean Diet><Metabolic><Metabolic Processes><Metabolism><Metadata><Metagenomics><Methodology><Microbe><Mind><Modality><Modification><Molecular><NMR Imaging><NMR Tomography><Nervous System Degenerative Diseases><Network-based><Neural Degenerative Diseases><Neural degenerative Disorders><Neuritic Plaques><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Nuclear Magnetic Resonance Imaging><Nutrition Interventions><Nutritional Interventions><Outcome><Participant><Pathogenesis><Pathway interactions><People at risk><Persons at risk><Phenotype><Phylogenetic Analysis><Phylogenetics><Physicians><Plants><Play><Population><Populations at Risk><Prevalence><Preventive><Primary Senile Degenerative Dementia><Process><Production><Proliferating><Public Health><Reproducibility><Research><Resolution><Risk Factors><Role><Sampling><Scientist><Senile Plaques><Serum><Standardization><Structure><Subgroup><Testing><United States><Work><Zeugmatography><abeta accumulation><abeta aggregation><age associated><age correlated><age dependent><age linked><age related><age specific><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging population><alzheimer risk><amyloid beta accumulation><amyloid beta aggregation><amyloid beta plaque><amyloid β accumulation><amyloid β aggregation><amyloid-b plaque><analyzing longitudinal><arm><aβ accumulation><aβ aggregation><aβ plaques><brain health><career><causation><cholesterol metabolism><clinical intervention><clinical relevance><clinical therapy><clinically relevant><cognitive dysfunction><cognitive loss><cohort><community microbes><computational toolbox><computational tools><computational toolset><computerized tools><cored plaque><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><dementia risk><developmental><diet alteration><diet intervention><dietary><dietary alteration><diets><diffuse plaque><digestive tract microbiome><disease causation><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><experiment><experimental research><experimental study><experiments><fecal sample><full genome><gastrointestinal microbial flora><gastrointestinal microbiome><genome sequencing><group intervention><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><host microbiota><host microflora><imaging><improved><intervention arm><intervention research><interventional research><interventional study><interventions research><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><life style intervention><lifestyle intervention><longitudinal analysis><longitudinal course><machine based learning><machine learning based method><machine learning based model><machine learning method><machine learning methodologies><machine learning model><meta data><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbe community><microbial><microbial community><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota composition><microorganism community><multiomics><multiple omics><neurodegenerative illness><new diagnostics><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation diagnostics><next generation therapeutics><novel diagnostics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><panomics><pathway><polymicrobial community><population aging><post intervention><primary degenerative dementia><prognostic><resident microbes><resident microflora><resolutions><responders and non-responders><responders from non-responders><responders or non-responders><responders versus non-responders><responders vs non-responders><responders/nonresponders><response><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sex><social role><stool sample><stool specimen><therapeutic target><translational impact><treatment arm><trial regimen><trial treatment><whole genome>
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Sylvia Irene Becker-Dreps

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 38/100
Very recent
Active award
Career award
$197,612
FY 2026

Project Title

Understanding protection against norovirus at the maternal-child interface

Grant Number:

5K24AI141744-08

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/6/2018

End Date:

1/31/2029

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

MODIFIED ABSTRACT SECTION This K24 renewal builds upon the successful clinical research and mentorship performed by the candidate, Sylvia Becker-Dreps, MD, MPH. As a natural extension of Dr. Becker-Dreps’ previous work on human norovirus (NoV), this proposal expands her research skillset to investig...

Research Terms

<0-11 years old><Accounting><Antibodies><Assay><Bacteria><Bioassay><Biological Assay><Birth><Blood Group Antigens><Blood Serum><Breast Feeding><Breast Milk><Breastfed infant><Breastmilk><Cells Placenta-Tissue><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Investigator><Clinical Research><Clinical Study><Cohort Studies><Communicable Diseases><Complement><Complement Proteins><Complex><Data><Development><Epidemiology><Epithelial Cells><Family Practice><Feces><Funding><Future><GI microbiome><GI microbiota><Gastroenteritis><Gastrointestinal microbiota><Genotype><Glycobiology><Goals><HPLC><Health Instruction><Health Tutoring><Health education><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Human><Human Milk><Human Mother's Milk><Immune><Immunes><Immunity><Individual><Infant><Infection><Infectious Diseases><Infectious Disorder><Intervention><Investigators><K24 Award><Laboratories><Lactation><Leadership><Learning><Life><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Mammary Gland Milk><Maternal antibody><Measures><Mentors><Mentorship><Methods><Mid-Career Clinical Scientist Award (K24)><Modern Man><Mother's Milk><Mothers><NIH><National Institutes of Health><Natural History><Nicaraguan><Normal Placentoma><Norovirus><North Carolina><Norwalk-like Viruses><Oligosaccharides><Ownership><Parturition><Performance><Physicians><Placenta><Placenta Embryonic Tissue><Placentome><Play><Predisposing Factor><Predisposition><Prevention><R-Series Research Projects><R01 Mechanism><R01 Program><Receptor Protein><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Risk><Risk Factors><Role><Rotavirus Vaccines><Sampling><Sapovirus><Sapporo-like Viruses><Scientist><Serum><Shapes><Susceptibility><Time><Training Programs><United States National Institutes of Health><Universities><Viral Gastroenteritis><Weaning><Woman><Work><biobank><biorepository><breastfeeding infant><burden of disease><burden of illness><career><career development><cohort><cohort research study><cohort survey><complementation><develop a vaccine><develop vaccines><development of a vaccine><developmental><digestive tract microbiome><disease burden><early childhood><enteral infection><enteric infection><enteric microbial community><enteric microbiome><enteric microbiota><enteric pathogen infection><enteropathogen infection><enteropathogenic infection><epidemiologic><epidemiological><family medicine><gastrointestinal microbial flora><gastrointestinal microbiome><global health><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiome of infant><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><human milk oligosaccharides><infant gut microbiome><infected with enteropathogen><interdisciplinary approach><intestinal biome><intestinal epithelium><intestinal flora><intestinal infection><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intestine infection><kids><lactating><lactational><maternal milk><maternal serum><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><multidisciplinary approach><neonate gut microbiome><newborn gut microbiome><next generation><pathogen><patient oriented research><patient oriented study><pediatric><prevent><preventing><receptor><skill acquisition><skill development><skills><social role><stool><vaccine development><youngster>
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AARON M MILSTONE

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 38/100
Very recent
Active award
Career award
$160,988
FY 2026

Project Title

Mentoring in prevention of healthcare-associated infections and antibiotic resistance

Grant Number:

5K24AI141580-08

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

11/23/2018

End Date:

11/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Modified Project Summary/Abstract Section The applicant, Dr. Aaron Milstone, is a Pediatric Infectious Diseases Physician and Epidemiologist who has focused his career on the prevention of antibiotic resistance and healthcare-associated infections. The current proposal is a competitive renewal of...

Research Terms

<0-11 years old><AHCPR><AHRQ><Address><Advisory Committees><Agency for Health Care Policy and Research><Agency for Healthcare Research and Quality><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Area><Award><Biometrics><Biometry><Biostatistics><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Treatment><Collaborations><Communicable Diseases><Contracting Opportunities><Contracts><Dedications><Diagnostic><Epidemiologist><Epidemiology><Faculty><Funding><Genomics><Goals><Health><Health Care><Health Sciences><Hospitals><Human><Infection><Infection prevention><Infectious Diseases><Infectious Disorder><Intervention><Investigators><K-Awards><K-Series Research Career Programs><K24 Award><Knowledge><Laboratories><Learning><Manuscripts><Mentors><Mentorship><Microbiomics><Mid-Career Clinical Scientist Award (K24)><Miscellaneous Antibiotic><Modeling><Modern Man><NIH><Nasal><Nasal Passages Nose><National Institutes of Health><Neonatal><New Agents><Nose><Observational epidemiology><Organism><Paper><Parents><Patients><Physicians><Population><Postdoc><Postdoctoral Fellow><Prevent infection><Prevention><Productivity><Research><Research Associate><Research Career Program><Research Personnel><Research Resources><Research Support><Researchers><Resistance><Resistance to antibiotics><Resistance to infection><Resistant to antibiotics><Resources><Respiratory System, Nose, Nasal Passages><Risk Factors><S aureus><S. aureus><Sampling><Science><Societies><Source><Staph aureus><Staphylococcus aureus><Task Forces><Testing><Time><Training><Training Programs><Translating><Transmission><United States Agency for Health Care Policy and Research><United States Agency for Healthcare Research and Quality><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><United States National Institutes of Health><Universities><Vulnerable Populations><Work><advisory team><antibiotic drug resistance><antibiotic resistance emergence><antibiotic resistant><blood infection><bloodstream infection><career><career development><child health care><clinical intervention><clinical therapy><cohort><emerging antibiotic resistance><epidemiologic><epidemiological><health care associated infections><implementation science><infection in the blood><infection of the blood><infection resistance><infection risk><kids><knowledge base><living system><malleable risk><medical college><medical schools><member><microbiome><microbiome research><microbiome science><microbiome studies><microbiome transplant><microbiome transplantation><microbiota transplant><microbiota transplantation><modifiable risk><nasal microbiome><next generation><novel><parent><patient centered><patient oriented><patient oriented research><patient oriented study><pediatric><pediatric care><pediatric health care><post-doc><post-doctoral><post-doctoral trainee><pre-doc><pre-doctoral><prevent><preventing><programs><public health priorities><recruit><research associates><resistant><school of medicine><sinonasal microbiome><transmission process><trial regimen><trial treatment><vulnerable group><vulnerable individual><vulnerable people><youngster>
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Alexandra Patterson

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Exploratory lead · 38/100
Very recent
Active award
Career award
$86,874
FY 2026

Project Title

Enabling Novel Strategies for the Clinical Care of Urinary Tract Infection via Microbial Engineering

Grant Number:

4K00DK143562-02

Activity Code:

K00

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2030

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Each year, urinary tract infections (UTI) affect over 400 million people worldwide, such that nearly half of all women will have a UTI within their lifetime. However, the exponential rise in antibiotic resistance of uropathogenic bacteria profoundly threatens our ability to treat UTI. Thus, it is im...

Research Terms

<Address><Advisory Committees><Affect><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Antimicrobial Resistance><Bacteria><Bacteria resistance><Bacteria resistant><Bacterial resistant><Bacteriophages><Base Pairing><Base Sequence><Binding><Biological Markers><Biology><Biomedical Engineering><Biosensor><Cell Communication and Signaling><Cell Signaling><Cessation of life><Clinical><Clinical Microbiology><Closure by Ligation><Complement><Complement Proteins><Consumption><Coupled><Death><Detection><Diagnosis><Diagnostic><Diagnostic Sensitivity><EC 1.1.1.27><Engineering><Ensure><Environment><Evolution><Freeze Drying><Freeze Dryings><Funding><Gene Transcription><Genes><Genetic Transcription><Goals><Health><Hour><In Situ><In Vitro><Industry><Infection><Institution><Intracellular Communication and Signaling><Investigators><Kidney Diseases><L-Lactate Dehydrogenase><L-Lactic Acid Dehydrogenase><Lactate Dehydrogenase><Lactobacillus><Lead><Ligation><Lyophilization><Measures><Mentors><Mice><Mice Mammals><Microbiology><Miscellaneous Antibiotic><Modeling><Molecular Interaction><Murine><Mus><NAD-Lactate Dehydrogenase><Nature><Nephropathy><Nucleic Acids><Nucleotide Sequence><Out-patients><Outpatients><Pathogenesis><Pathogenicity><Patients><Pb element><Persons><Phages><Postdoc><Postdoctoral Fellow><Prevention><Probiotics><Pyelonephritis><RNA Expression><Renal Disease><Research><Research Associate><Research Personnel><Researchers><Resistance><Resistance to antibiotics><Resistant to antibiotics><Sepsis><Signal Transduction><Signal Transduction Systems><Signaling><Symptoms><System><Task Forces><Technology><Testing><Time><Training><Transcription><Translations><Urinary Microbiome><Urinary Tract Diseases><Urinary tract infection><Urinary tract infectious disease><Urine><Urologic Diseases><Urologic Disorder><Urological Diseases><Urological Disorders><Urology><Uropathogen><Woman><Work><advisory team><anti-microbial resistant><antibiotic drug resistance><antibiotic resistant><bacteria pathogen><bacterial pathogen><bacterial resistance><bacterial virus><bio-engineered><bio-engineers><bio-markers><bioengineering><biologic marker><biological engineering><biological sensor><biological signal transduction><biomarker><career><clinical care><commensal community><commensal microbiome><commensal species><complementation><debilitating symptom><design><designing><diagnostic approach><diagnostic strategy><efficacy testing><gene therapeutics><gene-based therapeutic><gene-based therapeutics><genes therapeutic><genes therapeutics><heavy metal Pb><heavy metal lead><in vivo Model><kidney disorder><kidney infection><lactic acid dehydrogenase><member><microbial><microbial consortia><microbial flora><microbiome><microbiota><microflora><multispecies consortia><new approaches><new diagnostics><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation diagnostics><novel><novel approaches><novel diagnostics><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><nucleic acid detection><nucleic acid sequence><pathogenic bacteria><point of care><point-of-care diagnostics><post-doc><post-doctoral><post-doctoral trainee><rapid detection><renal disorder><research associates><resident commensals><resistance gene><resistance locus><resistance to Bacteria><resistance to Bacterial><resistance to anti-microbial><resistant><resistant gene><resistant to Bacteria><resistant to Bacterial><resistant to antimicrobial><synthetic biology><theories><therapeutic gene><translation><treatment strategy><urinary infection><urinary tract disorder>
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Leopoldo Nicolas Segal

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Exploratory lead · 34/100
Above-average budget
Active award
$652,880
FY 2026

Project Title

Local microbiota signatures of pro-tumor immunity and checkpoint inhibition susceptibility in lung cancer

Grant Number:

5R37CA244775-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract. PD-1 blockade has become first line therapy of most non-small cell lung cancer (NSCLC). However, given the variable effectiveness of immunotherapy in this disease there is a need to better understand factors that affect individual’s response to this therapy. The lung microbiota plays an im...

Research Terms

<1-Phosphatidylinositol 3-Kinase><16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Affect><Airway Disease><B7-H1><Biological Markers><Blood><Blood Plasma><Blood Reticuloendothelial System><CD274><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cancer Model><Cancer Patient><CancerModel><Cancers><Causality><Cell Body><Cells><Characteristics><Clinical><Clinical Trials><Color><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Data><Disease><Disorder><Distant><Early identification><Effectiveness><Eligibility><Eligibility Determination><Environment><Etiology><Evaluation><Feces><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Taxonomy><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immune><Immune mediated therapy><Immune response><Immunes><Immunity><Immunologically Directed Therapy><Immunomodulation><Immunotherapy><Inflammation><Inflammatory><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Intervention><Investigation><Link><LoxP-flanked allele><Lung><Lung Adenocarcinoma><Lung Respiratory System><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mediating><Metabolic><Methods><Mice><Mice Mammals><Microbe><Microbiomics><Modeling><Modification><Murine><Mus><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Newly Diagnosed><Non-Polyadenylated RNA><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><Outcome><PD 1><PD-1><PD-L1><PD1><PDL-1><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><Parents><Pathway interactions><Patients><Phenotype><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Plasma><Plasma Serum><Play><Pre-Clinical Model><Preclinical Models><Predisposition><Prevalence><Prevotella><Programmed Cell Death 1 Ligand 1><Programmed Death Ligand 1><Progression-Free Survivals><Protocol Screening><PtdIns 3-Kinase><Pulmonary Cancer><Pulmonary malignant Neoplasm><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Reticuloendothelial System, Serum, Plasma><Ribonucleic Acid><Ribosomal RNA><Ribosomal RNA Genes><Role><Sampling><Susceptibility><T cell response><T-Cells><T-Lymphocyte><Taxonomy><Testing><Tumor Burden><Tumor Immunity><Tumor Load><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><Validation><Veillonella><airway microbial community><airway microbiome><airway microbiota><anti-tumor immune response><anti-tumor immunity><antitumor immunity><aspirate><bio-markers><biologic marker><biomarker><cancer immunity><cancer microenvironment><causation><check point inhibition><checkpoint inhibition><clinical relevance><clinically relevant><design><designing><digestive tract microbiome><disease causation><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><flow cytophotometry><floxed><floxed allele><gastrointestinal microbial flora><gastrointestinal microbiome><global gene expression><global transcription profile><gut community><gut flora><gut lung communication><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><gut-lung axis><host response><immune check point><immune check point inhibition><immune checkpoint><immune checkpoint inhibition><immune modulation><immune regulation><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immunecheckpoint><immuno therapy><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><individual response><individualized response><individualized therapeutic><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><lung cancer><lung carcinogenesis><lung microbial community><lung microbiota><malignancy><metabolism measurement><metabolomics><metabonomics><metatranscriptome><metatranscriptomics><microbial><microbial consortia><microbial flora><microbial imbalance><microbial signature><microbiome><microbiome research><microbiome science><microbiome studies><microbiota><microbiota patterns><microbiota profiles><microbiota signature><microflora><mortality><mouse model><mucosa-associated microbes><mucosa-associated microbial community><mucosa-associated microbiota><mucosal flora><mucosal microbes><mucosal microbiota><mucosal microflora><multiomics><multiple omics><multispecies consortia><murine model><neo-antigen><neo-epitopes><neoantigens><neoepitopes><neoplasm/cancer><novel><oral commensal><panomics><parent><pathway><personalized therapeutic><pre-clinical><preclinical><predict responsiveness><predicting response><primary outcome><programmed cell death 1><programmed cell death ligand 1><programmed cell death protein 1><programmed cell death protein ligand 1><programmed death 1><prospective><protein death-ligand 1><pulmonary><pulmonary microbial community><pulmonary microbiota><rRNA><rRNA Genes><respiratory microbiome><respiratory microbiota><respiratory tract microbiome><response><response to therapy><response to treatment><risk stratification><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><sle2><social role><stool><stratify risk><systemic lupus erythematosus susceptibility 2><therapeutic outcome><therapeutic response><therapy outcome><therapy responders><therapy response><thymus derived lymphocyte><trait><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><treatment responders><treatment response><treatment responsiveness><tumor><tumor microenvironment><validations>
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JOHN A GERLT

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Exploratory lead · 34/100
Above-average budget
Active award
$561,185
FY 2026

Project Title

Web-Based Resource for Genomic Enzymology Tools

Grant Number:

5R24GM141196-05

Activity Code:

R24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/10/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT This application requests support for a web-based resource that provides community access to “genomic enzymology” tools to 1) enable identification of uncharacterized proteins for functional discovery, including those that are present in human microbiome and other metagenomi...

Research Terms

<Adult-Onset Diabetes Mellitus><Amino Acid Sequence><Amino Acid Sequence Databases><Archaea><Archaeal Gene Products><Archaeal Gene Proteins><Archaeal Peptides><Archaeal Proteins><Archaebacteria><Archaeobacteria><Archaeon><Archives><Bacteria><Bacterial Gene Products><Bacterial Gene Proteins><Bacterial Proteins><Biochemical><Bioinformatics><Chemicals><Color><Communities><Data Bases><Data Set><Databases><Democracy><Development><Disease><Disorder><ESTs><Environment><Enzymatic Biochemistry><Enzyme Gene><Enzymes><Enzymology><European><Expressed Sequence Tags><Family><Functional Metagenomics><Fungal Gene Products><Fungal Gene Proteins><Fungal Proteins><Gene Transcription><Genes><Genetic Transcription><Genome><Genomics><Gestation><Guilt><Human Microbiome><Individual><International><Intestinal><Intestines><Jobs><Ketosis-Resistant Diabetes Mellitus><Knowledge><Legal patent><Maps><Maturity-Onset Diabetes Mellitus><Metabolic><Metabolic Pathway><Metagenomics><NIDDM><NIGMS><NIH RFA><National Institute of General Medical Sciences><Natural Products><Neighborhoods><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nucleotides><Occupations><Ontology><Patents><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Physiologic><Physiological><Pregnancy><Primary Protein Structure><Professional Positions><Protein Family><Protein Sequence Databases><Proteins><Publications><RNA Expression><Request for Applications><Research Resources><Resources><Running><SEQ-AN><Scientific Publication><Sequence Analyses><Sequence Analysis><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Survey Instrument><Surveys><Systems Biology><T2 DM><T2D><T2DM><Transcription><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Visualization><adult onset diabetes><bio-informatics tool><bioinformatics tool><biophysical characteristics><biophysical characterization><biophysical measurement><biophysical parameters><biophysical properties><bowel><candidate identification><cartilage link protein><chemical library><computational infrastructure><computer infrastructure><computer program><computer programming><data base><developmental><fungus><fungus protein><genome analysis><genome database><genome resource><genomic data resource><genomic resource><genomic sequencing resource><human-associated microbiome><improved><in vitro activity><in vivo><interest><internet resource><ketosis resistant diabetes><link protein><maturity onset diabetes><metagenome><metatranscriptome><microbial><microbiome><microbiome community><naturally occurring product><novel><on-line compendium><on-line resource><online compendium><online resource><pharmaceutical><protein sequence><prototype><response><screening><screenings><small molecule libraries><tool><type 2 DM><type II DM><type two diabetes><web resource><web-based resource>
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Julia Brown

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Exploratory lead · 34/100
Training-friendly
Active award
$91,324
FY 2026

Project Title

Defining the role of premature infant microbial dysbiosis in mediating immune development and response to infection

Grant Number:

5F32HD112151-02

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

11/1/2024

End Date:

10/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Abstract The gut microbiome plays a critical role in the development of the immune system during the first year of life. Contact between immune cells and commensal microbes during early life helps to fine-tune this balance, and early-life perturbations to the microbiome have been linked to later sus...

Research Terms

<Affect><Airway infections><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antibody Response><Antibody Therapy><Antigen Presentation><Asthma><Award><B blood cells><B cell><B cells><B thetaiotaomicron><B-Cells><B-Lymphocytes><B-cell><B. thetaiotaomicron><Bacillus thetaiotaomicron><Bacteria><Bacteroides><Bacteroides thetaiotaomicron><Birth><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Body Tissues><Bronchial Asthma><Bronchial Constriction><Bronchiolitis><Bronchoconstriction><COPD><Cell Body><Cells><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical Treatment Moab><Clinical Trials><Co-culture><Cocultivation><Coculture><Coculture Techniques><Coliform Bacilli><Collaborations><Complex><Data><Dendritic Cells><Dendritic cell activation><Development><Disease><Disorder><Eligibility><Eligibility Determination><Enteric Bacteria><Enterobacteria><Enterobacteriaceae><Equilibrium><Feces><Foundations><GI microbiome><Gastrointestinal Diseases><Generations><Germ-Free><Gestation><Health><IFN><Immune><Immune Regulators><Immune response><Immune system><Immunes><Immunity><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunomodulation><Immunomodulators><Immunosuppressed Host><Impairment><In Vitro><Infant><Infection><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Innate Immune Response><Interferons><Intravenous Feeding><Intravenous Hyperalimentation><Irritable Bowel Syndrome><Irritable Colon><Life><Link><Lung><Lung Respiratory System><Lung damage><Lung immune response><Macrophage><Marrow Neutrophil><Mediating><Mentors><Mice><Mice Mammals><Miscellaneous Antibiotic><Monoclonal Antibodies><Mucous Colitis><Murine><Mus><Mφ><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Outcome><Parenteral Feedings><Parenteral Nutrition><Parturition><Play><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Predisposition><Pregnancy><Premature Infant><Preventative intervention><Protocol Screening><RSV Vaccines><RSV infection><Regulatory T-Lymphocyte><Respiratory Infections><Respiratory Syncytial Virus Infections><Respiratory Syncytial Virus Vaccines><Respiratory Tract Infections><Respiratory syncytial virus><Risk><Role><S thetaiotaomicron><S. thetaiotaomicron><Shapes><Sphaerocillus thetaiotaomicron><Sphingolipids><Surface><Susceptibility><Therapeutic><Tissues><Transplantation><Treg><Vaccines><Veiled Cells><Viral><Work><adaptive immune response><adverse consequence><adverse outcome><airway immune response><alter microbiome><antibody based therapies><antibody treatment><antibody-based therapeutics><antibody-based treatment><bacteria in the gut><balance><balance function><child patients><chronic obstructive pulmonary disorder><commensal community><commensal flora><commensal microbes><commensal microbiome><commensal microbiota><commensal microflora><commensal species><defined contribution><developmental><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbiome><experience><gastrointestinal disorder><gastrointestinal microbiome><gut bacteria><gut microbiome><gut-associated microbiome><high risk><high risk infant><host response><hyperalimentation><hyperalimentation therapy><immune modulation><immune modulators><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunomodulatory molecules><immunoregulation><immunoregulator><immunoregulatory><immunoregulatory molecules><immunoresponse><immunosuppressed patient><improved><improved outcome><in vivo><infants born premature><infants born prematurely><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><intervention for prevention><intestinal autoinflammation><intestinal biome><intestinal microbiome><later in life><later life><long-term hospitalization><lung development><lung function><lung injury><mAbs><microbial><microbial imbalance><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><monoclonal Abs><neonatal immune system><neonatal mice><neutralizing antibody><neutrophil><pathogen><pediatric patients><premature><premature baby><premature infant human><prematurity><preterm baby><preterm infant><preterm infant human><prevention intervention><preventional intervention strategy><preventive intervention><pulmonary damage><pulmonary function><pulmonary immune response><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><regulatory T-cells><resident commensals><respiratory><respiratory immune response><response><social role><spastic colon><stool><trafficking><transplant><vulnerable infant>
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Brittany Anne Seibert

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 34/100
Training-friendly
Active award
$79,828
FY 2026

Project Title

Microbiome-induced changes following influenza infection during pregnancy

Grant Number:

5F32HD117584-02

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Influenza A virus (IAV) impacts pregnant women and their offspring to a greater extent than the general population during pandemics and seasonal epidemics. Pregnancy is a risk factor for severe outcomes from IAV infection, including increased risk of hospital admission and death, and...

Research Terms

<0-11 years old><Affect><Airway infections><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Antimicrobial Effect><Autoregulation><Bacteria><Bacteriology><Bifidobacterium><Blood><Blood Reticuloendothelial System><Body Tissues><Body Weight><Cell Body><Cells><Cells Placenta-Tissue><Cessation of life><Child><Child Youth><Children (0-21)><Clinical><Colon><Data><Death><Development><Developmental Delay><Developmental Delay Disorders><Disease><Disorder><Epidemic><FITC-dextran><Fetal Growth><Fetal Growth Restriction><Fetal Growth Retardation><Fetus><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Population><General Public><Generalized Growth><Germ-Free><Gestation><Goals><Growth><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><H1N1><H1N1 Virus><Homeostasis><Hospital Admission><Hospitalization><IUGR><Immune><Immune response><Immunes><Immunology><Immunomodulation><Individual><Infection><Inflammation><Inflammatory><Influenza A><Influenza A Virus, H1N1 Subtype><Influenza A virus><Influenza Viruses Type A><Influenzavirus A><Intestinal><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Intrauterine Growth Retardation><LPS-binding protein><Lactobacillus><Length><Low Birth Weight Infant><Lung><Lung Respiratory System><Measures><Metabolic Diseases><Metabolic Disorder><Mice><Mice Mammals><Microbe><Miscellaneous Antibiotic><Monitor><Morbidity><Morphology><Murine><Mus><Normal Placentoma><Nutrient><Orthomyxovirus Type A><Outcome><Pathway interactions><Perinatal><Peripartum><Permeability><Physiologic><Physiological><Physiological Homeostasis><Placenta><Placenta Embryonic Tissue><Placentome><Play><Population><Pregnancy><Pregnant Women><Premature Birth><Prematurely delivering><Preterm Birth><Probiotics><Production><Pulmonary Body System><Pulmonary Organ System><Regulatory T-Lymphocyte><Reporting><Research><Respiratory Infections><Respiratory System><Respiratory Tract Infections><Respiratory Tracts><Respiratory tract structure><Risk><Risk Factors><Role><Seasons><Short-Chain Fatty Acids><Specific Child Development Disorders><Steroid Compound><Steroids><Structure><Supplementation><Therapeutic><Therapeutic Uses><Thesaurismosis><Tissue Growth><Tissues><Training><Treg><Type A Influenza><Viral><Viral Diseases><Viral Respiratory Tract Infection><Virus><Virus Diseases><Virus Replication><Volatile Fatty Acids><Weaning><Weight><anti-microbial effect><bacteria pathogen><bacterial disease treatment><bacterial infectious disease treatment><bacterial pathogen><bowel><cytokine><developmental><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><expectant mother><expectant women><expecting mother><expecting women><experience><experiment><experimental research><experimental study><experiments><fatty acid-binding proteins><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><fetal><flu infection><flu virus infection><fluorescein isothiocyanate dextran><fluoresceinthiocarbamoyl dextrans><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut dysbiosis><gut flora><gut lung communication><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><gut-lung axis><host response><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><impaired fetal growth><improved><individuals who are pregnant><infected with flu><infected with flu virus><infected with influenza><infected with influenza virus><influenza infection><influenza virus infection><innovate><innovation><innovative><insight><intestinal barrier><intestinal biome><intestinal epithelium><intestinal fatty acid binding protein><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal mucosal barrier><intestinal tract microflora><intra-uterine growth><intra-uterine growth restriction><intra-uterine growth retardation><intrauterine growth><intrauterine growth restriction><kids><lipopolysaccharide-binding protein><low birth weight><low birthweight><maternal GI tract><maternal gut><maternal microbiome><maternal morbidity><metabolism disorder><microbial><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community><microbiota><microflora><model of animal><mother's gut><mouse model><multispecies consortia><murine model><neuropsychiatric disease><neuropsychiatric disorder><offspring><ontogeny><pandemic><pandemic concern><pandemic disease><pandemic potential><pandemic risk><pandemic threat><pathogenic bacteria><pathogenic virus><pathway><people who are pregnant><perinatal outcomes><prebiotics><pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><premature childbirth><premature delivery><prenatal growth disorder><preterm delivery><prevent><preventing><probiotic supplement><probiotic supplementation><regulatory T-cells><respiratory><social role><stillbirth><stillborn><supplementation with probiotics><those who are pregnant><viral infection><viral multiplication><viral pathogen><viral replication><viral respiratory infection><virus infection><virus multiplication><virus pathogen><virus-induced disease><weights><women who are pregnant><youngster>
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Christine Melody Tin

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 34/100
Training-friendly
Active award
$55,114
FY 2026

Project Title

Breast Milk IgA Exerts Selective Pressure on the Preterm Gut Microbiome

Grant Number:

5F30HD114316-03

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY This proposal aims to characterize how breast milk IgA shapes the ecological development of the preterm gut microbiome and promotes resistance to pathobionts. Aberrant gut bacterial colonization places the preterm infant at risk for necrotizing enterocolitis (NEC). NEC is a deadly i...

Research Terms

<Acceleration><Address><Affect><Anaerobic Bacteria><Anti-Bacterial Agents><Antibodies><Bacteria><Bar Codes><Bifidobacterium><Binding><Biological Function><Biological Process><Biology><Birth><Breast Milk><Breastmilk><Cell Body><Cells><Childhood><Clinical><Coliform Bacilli><Collaborations><Communities><DNA mutation><Data><Data Bases><Data Set><Databases><Development><Diagnosis><Disease><Disorder><Ecologic Systems><Ecological Systems><Ecosystem><Enteric Bacteria><Enterobacteria><Enterobacteriaceae><Evolution><Exhibits><Exocrine IgA><Failure to Thrive><Feces><Fetal health><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene variant><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genomics><Goals><Health><Human Milk><Human Mother's Milk><IgA><Immune><Immune Globulins><Immunes><Immunoglobulin A><Immunoglobulins><In Situ><Individual><Infant><Infant Development><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal><Intestines><Knowledge><Label><Laboratories><Life><Link><Mammary Gland Milk><Maternal-fetal medicine><Milk><Molecular Interaction><Mother's Milk><Mothers><Mutation><Necrotizing Enterocolitis><Neurodevelopmental Impairment><Non-Polyadenylated RNA><Outcome><Parturition><Pathogenesis><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Physicians><Population><Population Dynamics><Population Sizes><Predisposition><Premature Infant><Prospective Studies><Prospective, cohort study><RNA><RNA Gene Products><Reaction><Research><Resistance><Resolution><Ribonucleic Acid><Risk><Role><SIgA><Sampling><Scientist><Secretory IgA><Secretory Immunoglobulin A><Shapes><Source><Survivors><Susceptibility><Testing><Therapeutic><Time><Training><Variant><Variation><Work><allelic variant><alter microbiome><anaerobe><analyzing longitudinal><anti-IgA><anti-bacterial><barcode><bowel><career><cohort><curative intervention><curative therapeutic><curative therapy><curative treatments><data base><design><designing><developmental><digestive tract microbiome><driving force><enteric microbial community><enteric microbiome><enteric microbiota><fecal sample><flow cytophotometry><gastrointestinal microbial flora><gastrointestinal microbiome><genetic variant><genome mutation><genomic variant><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiome of infant><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><improved><infant gut microbiome><infants born premature><infants born prematurely><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><intestinal autoinflammation><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><longitudinal analysis><maternal milk><microbial><microbial consortia><microbial flora><microbial signature><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><microbiota><microbiota patterns><microbiota profiles><microbiota signature><microflora><mouse model><multispecies consortia><murine model><neonate gut microbiome><new approaches><new technology><newborn gut microbiome><novel approaches><novel strategies><novel strategy><novel technologies><pathobiont><patient centered><patient oriented><patient oriented outcomes><pediatric><premature baby><premature infant human><pressure><preterm baby><preterm infant><preterm infant human><prevent><preventing><prospective research study><prospective survey><resistant><resolutions><response><social role><stool><stool sample><stool specimen><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><trait>
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Tristan C. Sanford

UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OKLAHOMA CITY, OK

Exploratory lead · 34/100
Training-friendly
Active award
$47,542
FY 2026

Project Title

Human gut Bacteroidales defense mechanisms against emerging antibacterial toxins

Grant Number:

5F31AI189149-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The human colon harbors a rich microbial community engaged in fierce competition for nutrients and territory. In healthy individuals, the Gram-negative bacterial order Bacteroidales comprise a large component of the colonic bacteria and secrete many antibacterial molecules to antagon...

Research Terms

<1H-Purin-6-amine><Address><Adenine><Adenine Nucleotides><Adenosine Phosphates><Affect><Amino Acids><Anti-Bacterial Agents><B fragilis><B. fragilis><Bacterial Toxins><Bacteroides fragilis><Binding><Caspase><Caspase Gene><Cell Function><Cell Physiology><Cell Process><Cell Protection><Cell surface><Cell-Death Protease><Cellular Function><Cellular Physiology><Cellular Process><Cholesterol><Co-culture><Cocultivation><Coculture><Coculture Techniques><Colon><Complex><Coupled><Cysteine><Cysteine Endopeptidases><Cysteine Protease><Cysteine Proteinases><Cytolysins><Cytoprotection><DNA mutation><Data><Defense Mechanisms><Disease><Disorder><Distant><Environment><Environmental Factor><Environmental Risk Factor><Esteroproteases><FRET><Family><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Fluorescence><Fluorescence Resonance Energy Transfer><Frame Shift Mutation><Frameshift Mutation><Functional Metagenomics><Förster Resonance Energy Transfer><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genes><Genetic Change><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Gnotobiotic><Gnotobiotics><Half-Cystine><Health><Human><ICE-like protease><Individual><Intermediary Metabolism><L-Cysteine><Laboratories><Link><Measures><Mediating><Membrane><Metabolic Processes><Metabolism><Metagenomics><Methods><Mice><Mice Mammals><Modern Man><Molecular Interaction><Monitor><Murine><Mus><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Nutrient><Pattern><Peptidases><Peptide Hydrolases><Population><Process><Production><Protease Gene><Proteases><Protein Cleavage><Protein Secretion><Proteinases><Proteins><Proteolysis><Proteolytic Enzymes><Reading Frame Shift Mutation><Regulation><Resistance><Sigma Element><Sigma Factor><Sigma Initiation Factor><Sigma Subunit><Stress><Stretching><Subcellular Process><Surface><Targeted Toxins><Testing><Toxic effect><Toxicities><Toxin><Vitamin B4><aminoacid><antagonism><antagonist><anti-bacterial><arm><bacterial fitness><biological adaptation to stress><colon bacteria><colonic bacteria><community engagement><community microbes><cystein protease><cystein proteinase><cysteine endopeptidase><cytoprotective><digestive tract microbiome><engagement with communities><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><experiment><experimental research><experimental study><experiments><extracellular><flow cytophotometry><fluorophore><gastrointestinal microbial flora><gastrointestinal microbiome><genome mutation><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><indexing><insight><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><member><membrane structure><metabolic profile><microbe community><microbial community><microbial consortia><microbial flora><microbiota><microflora><microorganism community><monomer><multispecies consortia><mutant><novel><polymicrobial community><preservation><pressure><psychological defense mechanism><reactioncrisis><receptor binding><receptor bound><recruit><resistance mechanism><resistant><resistant mechanism><stress response><stressreaction>
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Jeremy K Lessing

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 34/100
Training-friendly
Active award
$46,714
FY 2026

Project Title

Caesarean Delivery's Effect on the Early Life Microbiome and Neurodevelopment

Grant Number:

5F30HD107912-04

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT The microbiome is the community of bacteria, fungi, and viruses that live in and on a host. Over the past few decades, advances in sequencing technology have allowed us to better understand the composition of the mammalian microbiome and the ways it affects host developmen...

Research Terms

<0-11 years old><0-4 weeks old><2nd trimester><A vaginae><A. vaginae><AD/HD><ADHD><ASD><Abdominal Delivery><Affect><Allergic to food><Allergy to food><Ammon Horn><Anesthesia><Anesthesia procedures><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Asthma><Atopobium vaginae><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Bacteria><Bacterial Genes><Biological><Bionomics><Birth><Body Tissues><Brain><Brain Hypoxia-Ischemia><Brain Nervous System><Brain region><Brittle Diabetes Mellitus><Bronchial Asthma><C section><Causality><Cecum><Cell Body><Cells><Cerebellum><Cesarean><Cesarean section><Child><Child Youth><Childhood><Children (0-21)><Cohort Studies><Communication><Communities><Cornu Ammonis><Development><Early Infantile Autism><Ecology><Emotional><Encephalon><Epidemiology><Etiology><Exclusion><Exhibits><Experimental Designs><Expression Signature><Feces><Food Allergy><Food Hypersensitivity><Fore-Brain><Forebrain><Fostering><Future><GI colonization><GI microbiome><GI microbiota><Gastrointestinal microbiota><Gene Expression><Gene Expression Profile><Genes><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Goals><Hippocampus><Histology><Human><IDDM><Impairment><Infant><Infantile Autism><Inherited Predisposition><Inherited Susceptibility><Insulin-Dependent Diabetes Mellitus><Investigators><Juvenile-Onset Diabetes Mellitus><Kanner's Syndrome><Ketosis-Prone Diabetes Mellitus><Knowledge><Label><Language><Large Intestine><Learning><Learning Disabilities><Learning disability><Life><Mammalia><Mammals><Medial><Medical><Memory><Messenger RNA><Methods><Mice><Mice Mammals><Microbe><Midtrimester><Miscellaneous Antibiotic><Modeling><Modern Man><Mothers><Motor><Murine><Mus><NGS Method><NGS system><Neural Development><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurodevelopmental Disorder><Neurological Development Disorder><Neurosciences><Newborn Infant><Newborns><Obesity><Parturition><Pathogenesis><Pathway interactions><Pattern><Phenotype><Physicians><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prefrontal Cortex><Prevalence><Proliferating><Prosencephalon><Regulation><Research><Research Personnel><Researchers><Ribosomal RNA><Risk><Rodent><Rodentia><Rodents Mammals><S Period><S phase><Sampling><Schizophrenia><Schizophrenic Disorders><Scientist><Second Pregnancy Trimester><Second Trimester><Social Interaction><Structure><Sudden-Onset Diabetes Mellitus><Synthesis Period><Synthesis Phase><System><T1 DM><T1 diabetes><T1D><T1DM><Technology><Testing><Tissues><Training><Transmission><Transplantation><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Universities><Vagina><Vaginal birth><Vaginal delivery><Vaginal delivery procedure><Virus><Weaning><Work><Writing><adiposity><analyze microbiome><autism spectral disorder><autism spectrum disorder><autistic behavior><autistic behaviour><autistic spectrum disorder><autistic-like behavior><beta diversity><biologic><causation><cohort research study><cohort survey><community microbes><corpulence><critical period><deliver vaginally><dementia praecox><design><designing><developmental><developmental disease><developmental disorder><digestive tract microbiome><disease causation><enteric microbial community><enteric microbiome><enteric microbiota><epidemiologic><epidemiological><fungus><gastrointestinal><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal tract colonization><gene expression pattern><gene expression signature><genetic vulnerability><genetically predisposed><gut colonization><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><hippocampal><human disease><human fetal brain><hypoxia/ischemia><ileum><insulin dependent diabetes><insulin dependent type 1><intestinal biome><intestinal colonization><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><ischemia injury><ischemic injury><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><kids><large bowel><later in life><later life><mRNA><mRNA Expression><maternal flora><maternal microbiota><microbe community><microbial><microbial community><microbial composition><microbial consortia><microbial flora><microbiome><microbiome analysis><microbiome community composition><microbiome composition><microbiome intervention><microbiome species composition><microbiome structure><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><microorganism community><model of animal><mouse model><multispecies consortia><murine model><myelination><neonatal period><neurodevelopment><neurodevelopmental disease><neurogenesis><newborn child><newborn children><next gen sequencing><next generation sequencing><nextgen sequencing><offspring><pathway><pediatric><polymicrobial community><post-natal development><post-natal period><postnatal><postnatal development><postnatal period><pregnant><protein expression><pup><rRNA><response><restoration><schizophrenic><sensory integration><skills><stool><stressor><transcriptional profile><transcriptional signature><transcriptomics><transmission process><transplant><type I diabetes><type one diabetes><vaginal flora><vaginal microbial community><vaginal microbiota><vaginal microflora><youngster>
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Benjamin Burke

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Exploratory lead · 34/100
Training-friendly
Active award
$45,071
FY 2026

Project Title

Using the gut microbiome to treat disuse atrophy in aging.

Grant Number:

5F31AG087618-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT The age-related loss of skeletal muscle mass and function has considerable effects on autonomy, quality of life, and disease prognosis. These negative outcomes can be exacerbated by diseases or treatments that induce immobilization. Older adults are especially susceptible to...

Research Terms

<Accidents><Affect><Age><Aging><Area><Atrophic><Atrophy><Attenuated><Award><Bioinformatics><Clinical><Communication><Data><Development><Discipline><Disease><Disorder><Disuse Atrophy><Elderly><Exercise><Experimental Designs><Extremities><Faculty><Fellowship><Flexor><GI microbiome><Gait><Generalized Growth><Goals><Growth><Health><Hindlimb><Hindlimb Elevation><Hindlimb Immobilization><Hindlimb Suspension><Hindlimb Unloading><Hospital Admission><Hospitalization><Immobilization><Immunoblotting><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><Injury><Limb structure><Limbs><Link><Literature><Maintenance><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measurement><Measures><Medical Rehabilitation><Mentorship><Mice><Mice Mammals><Microbiology><Microscopy><Modeling><Murine><Mus><Muscle><Muscle Atrophy><Muscle Tissue><Muscle function><Muscular Atrophy><Non-Trunk><Older Population><Oral><Outcome><Pathway interactions><Patients><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Population><Postdoc><Postdoctoral Fellow><Predisposition><QOL><Quality of life><Recovery><Regulation><Rehabilitation><Rehabilitation therapy><Research><Research Associate><Risk><Role><Skeletal Muscle><Succinates><Susceptibility><System><Testing><Therapeutic Intervention><Tissue Growth><Training><Universities><Voluntary Muscle><Western Blotting><Western Immunoblotting><Work><Writing><advanced age><age associated><age correlated><age dependent><age group><age linked><age related><age specific><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><ages><aging population><assess effectiveness><attenuate><attenuates><attenuation><candidate identification><decline in function><decline in functional status><determine effectiveness><developmental><digestive tract microbiome><disease prognosis><disease prognostication><drug candidate><effectiveness assessment><effectiveness evaluation><elderly mice><enteric microbiome><evaluate effectiveness><examine effectiveness><exercise training><experience><experiment><experimental research><experimental study><experiments><functional decline><functional status decline><gastrointestinal microbiome><geriatric><gut microbiome><gut-associated microbiome><injuries><intervention therapy><intestinal biome><intestinal microbiome><member><metabolism measurement><metabolomics><metabonomics><microbial><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle strength><muscle wasting><muscular><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><old mice><older adult><older adulthood><older groups><older individuals><older person><ontogeny><orthopedic freezing><pathway><pharmaceutical><population aging><post-doc><post-doctoral><post-doctoral trainee><preservation><prevent><preventing><protective effect><protein blotting><rehab therapy><rehabilitative><rehabilitative therapy><research associates><sedentary><senior citizen><skeletal muscle atrophy><skeletal muscle breakdown><skeletal muscle loss><skeletal muscle protein loss><skeletal muscle wasting><skeletal preservation><skills><social role><tenure process><tenure track>
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Ryan T Fansler

VANDERBILT UNIVERSITY, Nashville, TN

Exploratory lead · 34/100
Training-friendly
Active award
$35,435
FY 2026

Project Title

Iron homeostasis in sustaining commensal resilience in the inflamed gut

Grant Number:

5F31AI178950-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Abstract The homeostatic gut microbiota provides essential functions to multiple aspects of human health, including modulating the interactions between host and enteric pathogens. Perturbations, such as intestinal inflammation, can shift the beneficial microbiota to an imbalanced state frequently r...

Research Terms

<Affinity><Assay><Autoregulation><B thetaiotaomicron><B. thetaiotaomicron><Bacillus thetaiotaomicron><Bacteria><Bacteroides><Bacteroides thetaiotaomicron><Binding><Bioassay><Biochemical><Biological Assay><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cellular Function><Cellular Physiology><Cellular Process><Colitis><Couples><Coupling><Data><Disease><Disease Outcome><Disorder><Ecologic Systems><Ecological Systems><Ecosystem><Expenditure><Fe chelation><Fe element><Fe metabolism><GI commensal><GI microbiome><GI microbiota><Gastrointestinal microbiota><Generalized Growth><Genetic><Growth><Health><Homeostasis><Human><Immune system><In Vitro><Individual><Infection><Infection-induced colitis><Infectious colitis><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal><Intestines><Intracellular Communication and Signaling><Invaded><Iron><Iron Chelates><Iron Chelating Agents><Iron Chelation><Iron chelator><Knowledge><LCN2><LCN2 gene><Life><Lipocalin 2><Lipoproteins><Mediating><Membrane><Microbe><Micronutrients><Modeling><Modern Man><Molecular><Molecular Interaction><NGAL><Neutrophil Gelatinase-Associated Lipocalin><Nutrient><Nutritional><Nutritional Immunity><Oncogenic Lipocalin 24P3><Outcome><Physiological Homeostasis><Play><Predisposition><Process><Protein Secretion><Proteins><Regulation><Research><Role><S enterica serovar Typhimurium><S thetaiotaomicron><S typhimurium><S. enterica Typhimurium><S. enterica serovar Typhimurium><S. thetaiotaomicron><S. typhimurium><Salmonella enterica Typhimurium><Salmonella enterica serovar Typhimurium><Salmonella typhimurium><Shapes><Siderochromes><Siderophores><Signal Transduction><Signal Transduction Systems><Signaling><Small RNA><Sphaerocillus thetaiotaomicron><Starvation><Stress><Structure><Subcellular Process><Susceptibility><Testing><Therapeutic><Time><Tissue Growth><Uterocalin><Vesicle><Work><bacteria in the gut><biological signal transduction><bowel><bowel inflammation><clinical relevance><clinically relevant><colonization resistance><combat><commensal bacteria><commensal bacteria in the gastrointestinal tract><commensal bacteria in the gut><commensal bacteria in the intestine><commensal bacterial species><design><designing><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><effective therapy><effective treatment><enteral infection><enteral pathogen><enteric commensal><enteric infection><enteric microbial community><enteric microbiome><enteric microbiota><enteric pathogen><enteric pathogen infection><enteropathogen><enteropathogen infection><enteropathogenic infection><experiment><experimental research><experimental study><experiments><extracellular><fitness><gastrointestinal commensal><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut commensal><gut community><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><in vivo><infected with enteropathogen><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><insight><intestinal autoinflammation><intestinal biome><intestinal commensal><intestinal flora><intestinal infection><intestinal inflammation><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal pathogen><intestinal tract microflora><intestine infection><intestine pathogen><iron metabolism><kinetic model><membrane structure><microbial><microbial consortia><microbial flora><microbial imbalance><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microflora><model organism><mouse model><multispecies consortia><murine model><mutant><novel><nutritious><ontogeny><pathogen><resilience><resilient><response><small molecule><social role><therapeutic target><uptake>
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Elyza Amber Do

UNIVERSITY OF CALIFORNIA RIVERSIDE, RIVERSIDE, CA

Exploratory lead · 34/100
Training-friendly
Active award
$34,114
FY 2026

Project Title

Interpersonal variation in microbiome structure modulates inter-individual immune responses to Vibrio cholerae

Grant Number:

5F31AI179030-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/26/2023

End Date:

12/25/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Vibrio cholerae is a Gram-negative bacterium and the etiologic agent of cholera, a severe human diarrheal disease characterized by voluminous watery diarrhea and vomiting and when left untreated, severe dehydration, hypovolemic shock, and death. Several oral cholera vaccines (OCV) ha...

Research Terms

<Alimentary Canal><Antibody Response><Area><Automobile Driving><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Case Fatality Rates><Causality><Cell Body><Cells><Cessation of life><Characteristics><Cholera><Cholera Vaccine><Collection><Communities><Data><Death><Dehydration><Development><Diarrhea><Diet><Digestive Tract><East Indies><Economics><Emesis><Epidemic><Etiology><Exposure to><GI Tract><GI microbiota><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Geography><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><Gram-Negative Bacteria><Health Priorities><Human><Hypovolemic Shock><Immune><Immune response><Immune system><Immunes><Immunity><Immunization><Immunologic Subtyping><Immunology><Immunophenotyping><Impairment><Individual><Individual Differences><Indonesia><Infection><Infection with V cholerae><Infection with V. cholerae><Infection with Vibrio cholerae><Intestinal><Intestines><Lead><Left><Malay Archipelago><Malnutrition><Mediating><Mentorship><Mice><Mice Mammals><Microbe><Microbiology><Modeling><Modern Man><Morbidity><Murine><Mus><Nature><Netherlands East Indies><Nutritional Deficiency><Oral><Oral Rehydration Therapy><Outcome><Output><Pb element><Peripheral><Population><Predisposition><Probiotics><Prophylactic treatment><Prophylaxis><Regulatory T-Lymphocyte><Resolution><Role><Shapes><Structure><Susceptibility><System><T4 Cells><T4 Lymphocytes><Testing><Transplantation><Treg><Undernutrition><V cholerae><V cholerae infection><V. cholerae><V. cholerae infection><Vaccination><Variant><Variation><Vibrio cholerae><Vibrio cholerae infection><Vibrio comma><Vomiting><Work><alimentary tract><body water dehydration><bowel><causation><cholera infection><community microbes><developmental><diarrheal disease><diarrheal illness><dietary deficiency><diets><digestive canal><disease causation><driving><dysbacteriosis><dysbiosis><dysbiotic><economic><enteral infection><enteral pathogen><enteric infection><enteric microbial community><enteric microbiota><enteric pathogen><enteric pathogen infection><enteropathogen><enteropathogen infection><enteropathogenic infection><gastrointestinal microbial flora><geographic site><global health><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><heavy metal Pb><heavy metal lead><host microbiota><host microflora><host response><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiota><immune system response><immunoresponse><improved><infected with cholera><infected with enteropathogen><infection with cholera><insight><inter-individual variability><inter-individual variation><interest><intestinal flora><intestinal infection><intestinal microbiota><intestinal microflora><intestinal pathogen><intestinal tract microflora><intestine infection><intestine pathogen><malnourished><member><microbe community><microbial><microbial community><microbial composition><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome intervention><microbiome species composition><microbiome structure><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microbiota composition><microflora><microorganism community><mouse model><mucosal vaccination><mucosal vaccine><multispecies consortia><murine model><novel><nutrition deficiency><nutrition deficiency disorder><nutritional deficiency disorder><oral vaccine><outcome following vaccination><outcome following vaccine><polymicrobial community><prebiotics><prophylactic><protective efficacy><regulatory T-cells><resident microbes><resident microflora><resolutions><response><result following vaccination><result following vaccine><social role><transplant><vaccination outcome><vaccination result><vaccine efficacy><vaccine outcome><vaccine response><vaccine responsiveness><vaccine result><vaccine-induced response><volunteer>
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Andrew John Hryckowian

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 32/100
Solid budget
Recent
Active award
$434,684
FY 2026

Project Title

The impacts of glutathione on Clostridioides difficile infection

Grant Number:

1R21AI190655-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT Clostridioides difficile is a diarrheal pathogen that causes significant human morbidity and mortality. The status quo as it pertains to treating C. difficile infections (CDIs) is antibiotic use and, in recurrent cases, microbiome restoration therapy (MRT). Antibiotics contr...

Research Terms

<Address><Affect><Alimentary Canal><Amino Acids><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Antioxidants><Autoregulation><Bacteria><Bacterial Antibiotic Resistance><Body Tissues><C diff><C difficile><C. diff><C. difficile><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Cessation of life><Clostridioides difficile><Clostridium difficile><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Colon><Consumption><Coping Skills><Cysteine><DNA mutation><Data><Death><Diarrhea><Diet><Digestive Tract><Disabling><Disease><Disorder><Distal><Down-Regulation><Drugs><Environment><Enzyme Gene><Enzymes><Epithelial Cells><Feedback><Foundations><Funding><Future><GGTP><GI Tract><GI microbiome><Gamma-GT><Gamma-glutamyl transferase><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Deletion><Gene Expression><Generalized Growth><Genes><Genetic Change><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Gln><Glutamine><Glutamyl Transpeptidase><Glutathione><Growth><Half-Cystine><Health><Homeostasis><Human><In Vitro><Infection><Inflammation><Intermediary Metabolism><Intestinal><Intestinal Content><Intestines><Intoxication><Investigation><Isoleucine><Knowledge><L-Cysteine><L-Glutamine><L-Proline><L-Tryptophan><L-Valine><Leucine><Levotryptophan><Life><Mammalian Cell><Mediating><Medication><Mercaptans><Mercapto Compounds><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Microbe><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular Target><Molecular Weight><Murine><Mus><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Nutrient><Nutritional><Organism><Outcome><Pathogenesis><Peptides><Pharmaceutical Preparations><Phylogenetic Analysis><Phylogenetics><Physiological Homeostasis><Population><Probiotics><Production><Proline><Q Levoglutamide><Q. Levoglutamide><Recurrence><Recurrent><Resistance to antibiotics><Resistant to antibiotics><Risk><Risk Factors><Role><S element><Severities><Severity of illness><Signaling Molecule><Source><Sulfhydryl Compounds><Sulfur><Thiols><Tissue Growth><Tissues><Toxin><Trees><Tryptophan><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Valine><Work><alimentary tract><amino acid metabolism><aminoacid><antibiotic drug resistance><antibiotic resistant><antibiotic resistant bacteria><bacteria pathogen><bacterial antibiotic resistant><bacterial pathogen><bacterial resistance to antibiotic><beneficial flora><beneficial microbes><beneficial microflora><beneficial microorganism><bowel><coping strategy><diets><digestive canal><digestive tract microbiome><disease severity><drug development><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><enteric microbiome><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><fitness><gamma glutamyltranspeptidase><gamma-Glutamyl Transpeptidase><gamma-Glutamyltransferase><gamma-L-Glu-L-Cys-Gly><gamma-L-Glutamyl-L-Cysteinylglycine><gammaglutamyltransferase><gastrointestinal><gastrointestinal microbiome><gene deletion mutation><genome mutation><gut microbiome><gut-associated microbiome><human morbidity><human mortality><insight><intestinal biome><intestinal microbiome><living system><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><mouse model><murine model><mutant><new approaches><novel approaches><novel strategies><novel strategy><nutritious><ontogeny><pathogen><pathogenic bacteria><restoration><social role><sulfhydryl group><γ-Glutamyltransferase><γ-glutamyl transferase>
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MATTHEW D RAND

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Exploratory lead · 32/100
Solid budget
Recent
Active award
$415,613
FY 2026

Project Title

Influence of pregnancy and the gut microbiome on methylmercury metabolism and elimination in the mother and fetus

Grant Number:

1R21ES037489-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/24/2026

End Date:

1/31/2028

Project Abstract

Abstract. The developing fetus is exceptionally vulnerable to chemicals in the environment. Prenatal exposure to environmental contaminants, such as heavy metals, PFAS compounds and pesticides, impose a substantial societal cost due to the intellectual disability burden to children exposed early in ...

Research Terms

<0-11 years old><0-4 weeks old><1st trimester><21+ years old><3rd trimester><Ablation><Address><Adult><Adult Human><Assay><Bioassay><Bioinformatics><Biological Assay><Chemical Exposure><Chemicals><Child><Child Youth><Children (0-21)><Clinical><Consumption><Developing fetus><Early Placental Phase><Eating><Environment><Environmental Exposure><Environmental Pollutants><Environmental Toxin><Evaluation><Excretory function><Exposure to><Feces><Fetal Development><Fetus><First Pregnancy Trimester><First Trimester><Fishes><Food Intake><GI microbiome><Generalized Growth><Gestation><Goals><Growth><Guidelines><HAZMAT><Hair><Hazardous Materials><Hazardous Substances><Health><Health Benefit><Heavy Metals><Hg element><Human><In Vitro><Individual><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intermediary Metabolism><Kinetics><Knowledge><Laser Electromagnetic><Laser Radiation><Lasers><Last Trimester><Life><Link><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Maternal Health><Mediator><Mercury><Metabolic><Metabolic Processes><Metabolism><Methods><Methyl Mercury Compounds><Methylmercury Compounds><Modern Man><Modification><Monitor><Mothers><Neurotoxins><Newborn Infant><Newborns><Organism><Outcome Study><PFAS><Participant><Pathway interactions><Pesticides><Physiologic><Physiological><Poison><Poly-fluoroalkyl substances><Position><Positioning Attribute><Postpartum Period><Pregnancy><Pregnancy Trimesters><Pregnant Women><Prevention><Reporting><Risk><Self Administered><Self Administration><Testing><Third Pregnancy Trimester><Third Trimester><Time><Tissue Growth><Toxic Chemical><Toxic Environmental Agents><Toxic Environmental Substances><Toxic Substance><Toxic effect><Toxicant exposure><Toxicities><Toxicokinetics><Uncertainty><Upregulation><Variant><Variation><Woman><adulthood><changes associated with pregnancy><co-exposures><co-occurring exposure><combined exposure><complex exposure><concurrent exposure><contaminated drinking water><cost estimate><cost estimation><demethylation><dietary><digestive tract microbiome><disability burden><disease registry><doubt><drinking water contamination><enteric microbiome><environmental contaminant><environmental toxicant><excretion><expectant mother><expectant women><expecting mother><expecting women><exposed in utero><exposure mixture><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fecal sample><fetal><fetal exposure><gastrointestinal microbiome><gut microbes><gut microbial species><gut microbiome><gut-associated microbiome><haz mat><high reward><high risk><in utero exposure><in vivo><indexing><individuals who are pregnant><intellectual and developmental disability><intestinal biome><intestinal microbes><intestinal microbiome><intra-uterine environmental exposure><intrauterine environmental exposure><kids><limited intellectual functioning><living system><maternal GI tract><maternal gut><maternal microbiome><metagenome sequencing><metagenomic sequencing><methylmercury><microbial><microbial composition><mixed exposure><mother's gut><neurotoxicant><newborn child><newborn children><novel><ontogeny><pathway><people who are pregnant><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><polyfluorinated alkyl substances><polyfluoroalkyl substances><post-partum><pregnancy associated alterations><pregnancy associated changes><pregnancy induced alterations><pregnancy induced changes><pregnancy related alterations><pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal exposure><prenatally exposed><recruit><simultaneous exposures><societal costs><stool><stool sample><stool specimen><those who are pregnant><tool><toxic compound><toxic exposure><toxicant><trait><women who are pregnant><youngster>
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Kyla Ost

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 32/100
Solid budget
Recent
Active award
$412,422
FY 2026

Project Title

Investigating IgA regulation of Candida glabrata within the intestinal microbiome

Grant Number:

1R21AI191069-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Candida glabrata, also known as Nakaseomyces glabratus, is a leading cause of invasive candidiasis, which can have mortality rates as high as 60%. C. glabrata typically colonizes the intestinal microbiome, serving as the main source of infection. While it is recognized that strong an...

Research Terms

<Adherence><Adhesions><Adhesives><Alimentary Canal><Animal Model><Animal Models and Related Studies><Antibodies><Antibody Therapy><Antigens><Autoregulation><Bacterial Adhesins><C albicans><C. albicans><C. glabrata><C.albicans><Candida><Candida albicans><Candida glabrata><Candidiasis><Candidosis><Cessation of life><Clinical><Death><Death Rate><Detection><Digestive Tract><Exocrine IgA><Foundations><GI Tract><GI colonization><GI microbiome><Gastrointestinal Tract><Gastrointestinal tract structure><Genetics-Mutagenesis><Goals><Gut Mucosa><Homeostasis><Human><Hyphae><IgA><IgA Deficiency><Immune><Immune mediated therapy><Immune response><Immunes><Immunity><Immunoglobulin A><Immunologically Directed Therapy><Immunotherapy><In Vitro><Infection><Infection prevention><Inflammatory><Intestinal><Intestinal Mucosa><Intestines><Invaded><Knowledge><Mediating><Mice><Mice Mammals><Microbe><Modeling><Modern Man><Molecular Genetics><Monilia><Moniliasis><Mucosa><Mucosal Immune System><Mucosal Tissue><Mucous Membrane><Murine><Mus><Mutagenesis><Mutagenesis Molecular Biology><Opportunistic Infections><Ortholog><Orthologous Gene><Pathogenesis><Pathogenicity><Pathogenicity Factors><Patients><Physiological Homeostasis><Play><Prevent infection><Reaction><Regulation><Repression><Research><Resistance><Role><SIgA><Secretory IgA><Secretory Immunoglobulin A><Source><Specificity><Testing><Therapeutic><Therapeutic Fungicides><Torulopsis glabrata><Virulence Factors><Work><adhesin><alimentary tract><anti-fungal><anti-fungal agents><anti-fungal drug><antibody based therapies><antibody treatment><antibody-based therapeutics><antibody-based treatment><blood infection><bloodstream infection><bowel><commensal flora><commensal microbes><commensal microbiota><commensal microflora><develop a vaccine><develop vaccines><development of a vaccine><digestive canal><digestive tract microbiome><enteric microbiome><experiment><experimental research><experimental study><experiments><fitness><fungus><gastrointestinal><gastrointestinal microbiome><gastrointestinal tract colonization><genome wide screen><gut colonization><gut microbiome><gut-associated microbiome><host response><human model><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunoglobulin A deficiency><immunoresponse><in vivo><infection in the blood><infection of the blood><intestinal biome><intestinal colonization><intestinal epithelium><intestinal microbiome><medical vulnerability><member><microbial><microbial consortia><microbial flora><microbiota><microflora><model of animal><model of human><mortality rate><mouse model><multispecies consortia><murine model><opportunistic pathogen><prevent><preventing><resistant><response><social role><vaccine antibodies><vaccine development><vaccine induced antibodies><vaccine-induced antibodies><yeast infection>
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Hyun Jung Kim

CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH

Exploratory lead · 32/100
Solid budget
Recent
Active award
$400,890
FY 2026

Project Title

Microbiome-Mediated Tumor Immunomodulation in a Pathomimetic Colorectal Cancer Chip

Grant Number:

5R33CA286797-02

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2028

Project Abstract

ABSTRACT Immune checkpoint inhibitors (ICI) have demonstrated notable efficacy in various cancers, yet the majority of colorectal cancer (CRC) patients with mismatch repair-proficient (MMR-p) and microsatellite-stable (MSS) tumors do not respond to ICI-based immunotherapy. Recent research suggests t...

Research Terms

<3-D><3-D Imaging><3-Dimensional><3D><3D imaging><B7-H1><Bifidobacterium><CD152><CD152 Antigen><CD152 Gene><CD274><CTLA 4><CTLA-4 Gene><CTLA4><CTLA4 gene><CTLA4-TM><Cancers><Cell Body><Cell-Mediated Lympholytic Cells><Cells><Characteristics><Checkpoint inhibitor><Clinical><Co-culture><Cocultivation><Coculture><Coculture Techniques><Colon><Colorectal Cancer><Colorectal Neoplasms><Colorectal Tumors><Complex><Cytolytic T-Cell><Cytotoxic T Cell><Cytotoxic T-Lymphocyte Protein 4><Cytotoxic T-Lymphocyte-Associated Antigen 4><Cytotoxic T-Lymphocyte-Associated Protein 4><Cytotoxic T-Lymphocyte-Associated Serine Esterase-4><Cytotoxic T-Lymphocytes><Data Bases><Databases><Defecation><Demographic Impact><Demography><ELISA><Enzyme-Linked Immunosorbent Assay><Epithelial Cells><Epithelium><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Exploratory/Developmental Grant><Female><Fusobacterium><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genetic><Germ-Free><Goals><Image><Immune checkpoint inhibitor><Immune infiltrates><Immune mediated therapy><Immunofluorescence><Immunofluorescence Immunologic><Immunologically Directed Therapy><Immunomodulation><Immunotherapeutic agent><Immunotherapy><In Situ Hybridization><Intratumoral heterogeneity><Investigation><Knowledge><Large Bowel Tumor><Large Intestine Neoplasm><Large Intestine Tumor><Malignant Neoplasms><Malignant Tumor><Mediating><Microbe><Microbial Taxonomy><Microsatellite Markers><Microsatellite Repeats><Microsatellites><Mismatch Repair><Molecular><Molecular Analysis><Non-Polyadenylated RNA><Normal Tissue><Normal tissue morphology><O element><O2 element><Organoids><Outcome><Oxygen><PD 1><PD-1><PD-L1><PD1><PDL-1><Pathologic><Patients><Phenotype><Physiology><Post-Replication Mismatch Repair><Programmed Cell Death 1 Ligand 1><Programmed Death Ligand 1><Proteins><R21 Mechanism><R21 Program><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Racial Group><Reproducibility><Research><Ribonucleic Acid><Running><Solid Neoplasm><Solid Tumor><Sphaerophorus><Technology><Testing><Therapeutic><Three-Dimensional Imaging><Validation><Vascularization><Visual><Visualization><analyze microbiome><anti-cancer><anti-cancer immunotherapy><anti-cancer therapeutic><anti-tumor drug><anticancer immunotherapy><bowel movement><cancer immunotherapy><cancer microenvironment><chip model><chip system><colon cancer patients><colorectal cancer patients><colorectal neoplasia><cytotoxic T-lymphocyte antigen 4><data base><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><enzyme linked immunoassay><ethnic subgroup><ethnicity group><exploratory developmental study><fecal microbial community><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><fluid flow><gastrointestinal microbial flora><gastrointestinal microbiome><global gene expression><global transcription profile><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heterogeneity in tumors><host microbiome><imaging><immune cell infiltrate><immune check point><immune check point inhibitor><immune checkpoint><immune clearance><immune drugs><immune elimination><immune modulation><immune regulation><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapeutics><immune-based therapies><immune-based treatments><immunecheckpoint><immuno therapy><immunogenicity><immunologic reactivity control><immunologic therapeutics><immunomodulatory><immunoregulation><immunoregulatory><immunotherapeutics><immunotherapy agent><immunotherapy for cancer><immunotherapy of cancer><improved><in situ Hybridization Genetics><in situ Hybridization Staining Method><innovate><innovation><innovative><intestinal biome><intestinal epithelium><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intra-tumoral heterogeneity><intratumor heterogeneity><killer T cell><large bowel neoplasm><male><malignancy><microbial><microbial signature><microbiome><microbiome analysis><microphysiologic model><microphysiologic platform><microphysiologic system><microphysiology model><microphysiology platform><microphysiology system><molecular phenotype><neoplasm/cancer><new technology><novel technologies><on a chip><on chip><patient profile><pre-clinical><prebiotics><preclinical><probiotic supplement><probiotic supplementation><profiles in patients><programmed cell death 1><programmed cell death ligand 1><programmed cell death protein 1><programmed cell death protein ligand 1><programmed death 1><prophylactic><protein death-ligand 1><racial population><racial subgroup><response><sle2><socio-demographics><sociodemographics><supplementation with probiotics><systemic lupus erythematosus susceptibility 2><technology platform><technology system><therapeutic outcome><therapy outcome><three dimensional><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translational impact><tumor><tumor eradication><tumor heterogeneity><tumor microbiome><tumor microbiota><tumor microenvironment><tumor-associated microbiome><tumor-associated microbiota><validations><♀><♂>
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Douglas E. Brackney

CONNECTICUT AGRICULTURAL EXPERIMENT STA, NEW HAVEN, CT

Exploratory lead · 32/100
Solid budget
Recent
Active award
$322,096
FY 2026

Project Title

Uncovering the biological drivers of Aedes aegypti vector competence

Grant Number:

1R21AI196523-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2026

End Date:

1/31/2028

Project Abstract

Brackney & Steven Abstract: Aedes aegypti mosquitoes are the primary vector for numerous arthropod-borne (arbo) viruses including dengue virus (DENV; Flaviviridae, Flavivirus), Zika virus (ZIKV; Flaviviridae, Flavivirus), chikungunya virus (CHIKV; Togaviridae, Alphavirus) and yellow fever virus (YFV...

Research Terms

<21+ years old><A. aegypti><Ades aegypti><Adult><Adult Human><Ae. Aegypti><Aedes aegypti><Alpha Virus><Arboviral><Arboviruses><Arthropod Vectors><Arthropod-Borne Viruses><Assay><Bayesian Modeling><Bayesian adaptive designs><Bayesian adaptive models><Bayesian belief network><Bayesian belief updating model><Bayesian framework><Bayesian hierarchical model><Bayesian network model><Bayesian nonparametric models><Bayesian spatial data model><Bayesian spatial image models><Bayesian spatial models><Bayesian statistical models><Bayesian tracking algorithms><Bioassay><Biological><Biological Assay><Breakbone Fever Virus><CHIKV><CHIKV infection><Chikungunya virus><Communities><Competence><Culicidae><DENV><DENV infection><Data><Dengue Infection><Dengue Virus><Dengue fever virus><Dengue virus infection><Development><Diet><Dose><Expenditure><Exposure to><Flaviviridae><Flavivirus><Future><Genetic><Genotype><Goals><Group A Arboviruses><Group B Arbovirus><Health><Human><Hydrogen Oxide><Infection><Intervention><Laboratories><Larva><Maps><Measures><Mediating><Methods><Microbe><Modern Man><Mosquito Control><Mosquitoes><Orthoflavivirus><Outcome><Phenotype><Predisposition><Process><Public Health><QTL><Quantitative Trait Loci><Sampling><Series><Serotyping><Source><Standardization><Structure><Susceptibility><System><Temperature><Testing><Therapeutic><Togaviridae><Togaviruses><Transmission><Vaccines><Variant><Variation><Viral><Viral Genetics><Virus><Water><Yellow fever virus><ZIKV><Zika Virus><adulthood><arthropod transmission><arthropod transmitted><arthropod-borne><arthropodborne><biologic><chikungunya infection><chikungunya virus infection><community microbes><conditioning><dengue viral infection><density><developmental><diets><disease risk><disorder risk><experiment><experimental research><experimental study><experiments><human disease><human pathogen><infected with CHIKV><infected with chikungunya><infection rate><microbe community><microbial community><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microorganism community><novel><pathogen><polymicrobial community><rate of infection><spatial and temporal><spatial temporal><spatiotemporal><trait><transmission process><vector><vector competence><vectorial competence><virus genetics><zikav>
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Blaire T Steven

CONNECTICUT AGRICULTURAL EXPERIMENT STA, NEW HAVEN, CT

Exploratory lead · 32/100
Solid budget
Recent
Active award
$322,096
FY 2026

Project Title

Uncovering the biological drivers of Aedes aegypti vector competence

Grant Number:

1R21AI196523-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2026

End Date:

1/31/2028

Project Abstract

Brackney & Steven Abstract: Aedes aegypti mosquitoes are the primary vector for numerous arthropod-borne (arbo) viruses including dengue virus (DENV; Flaviviridae, Flavivirus), Zika virus (ZIKV; Flaviviridae, Flavivirus), chikungunya virus (CHIKV; Togaviridae, Alphavirus) and yellow fever virus (YFV...

Research Terms

<21+ years old><A. aegypti><Ades aegypti><Adult><Adult Human><Ae. Aegypti><Aedes aegypti><Alpha Virus><Arboviral><Arboviruses><Arthropod Vectors><Arthropod-Borne Viruses><Assay><Bayesian Modeling><Bayesian adaptive designs><Bayesian adaptive models><Bayesian belief network><Bayesian belief updating model><Bayesian framework><Bayesian hierarchical model><Bayesian network model><Bayesian nonparametric models><Bayesian spatial data model><Bayesian spatial image models><Bayesian spatial models><Bayesian statistical models><Bayesian tracking algorithms><Bioassay><Biological><Biological Assay><Breakbone Fever Virus><CHIKV><CHIKV infection><Chikungunya virus><Communities><Competence><Culicidae><DENV><DENV infection><Data><Dengue Infection><Dengue Virus><Dengue fever virus><Dengue virus infection><Development><Diet><Dose><Expenditure><Exposure to><Flaviviridae><Flavivirus><Future><Genetic><Genotype><Goals><Group A Arboviruses><Group B Arbovirus><Health><Human><Hydrogen Oxide><Infection><Intervention><Laboratories><Larva><Maps><Measures><Mediating><Methods><Microbe><Modern Man><Mosquito Control><Mosquitoes><Orthoflavivirus><Outcome><Phenotype><Predisposition><Process><Public Health><QTL><Quantitative Trait Loci><Sampling><Series><Serotyping><Source><Standardization><Structure><Susceptibility><System><Temperature><Testing><Therapeutic><Togaviridae><Togaviruses><Transmission><Vaccines><Variant><Variation><Viral><Viral Genetics><Virus><Water><Yellow fever virus><ZIKV><Zika Virus><adulthood><arthropod transmission><arthropod transmitted><arthropod-borne><arthropodborne><biologic><chikungunya infection><chikungunya virus infection><community microbes><conditioning><dengue viral infection><density><developmental><diets><disease risk><disorder risk><experiment><experimental research><experimental study><experiments><human disease><human pathogen><infected with CHIKV><infected with chikungunya><infection rate><microbe community><microbial community><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microorganism community><novel><pathogen><polymicrobial community><rate of infection><spatial and temporal><spatial temporal><spatiotemporal><trait><transmission process><vector><vector competence><vectorial competence><virus genetics><zikav>
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Erez N Baruch

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Exploratory lead · 30/100
Very recent
Active award
$248,658
FY 2026

Project Title

Adverse gut microbiome promotes resistance immune checkpoint inhibitors via chronic inflammation

Grant Number:

4R00CA296940-02

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project summary/abstract Immune checkpoint inhibitors (ICI) transformed oncological care for multiple cancers. Yet, 80% of ICI patients will eventually fail therapy. Colossal efforts are invested in overcoming ICI resistance. A promising candidate is the gut microbiome which was associated with ICI ...

Research Terms

<Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antigen-Presenting Cells><Antigens><Automobile Driving><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Bacteria><Blood Serum><CD11c><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cancer Patient><Cancers><Caring><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><Cell Wall><CellLine><Cells><Checkpoint inhibitor><Chronic><Clinical><Clinical Trials><Data><Dendritic Cells><Development><Donor person><Feces><GI microbiome><Genes><Grawitz Tumor><HPGF><Hepatocyte-Stimulating Factor><High-Frequency Microsatellite Instability><Hybridoma Growth Factor><Hypernephroid Carcinoma><Hypernephroma><IFN-beta 2><IFNB2><IL-1><IL-1 Receptors><IL-6><IL1><IL1 Receptors><IL6 Protein><ITGAX><ITGAX gene><Immune><Immune checkpoint inhibitor><Immune system><Immunes><Immunity><Impairment><Infiltration><Inflammation><Inflammation Mediators><Inflammatory><Inflammatory Response><Interleukin I><Interleukin-1><Interleukin-1 Receptors><Interleukin-6><Interleukins><Intracellular Communication and Signaling><Investments><Lipopolysaccharides><Lymphocyte-Stimulating Hormone><MGI-2><MSI-H><Macrophage Cell Factor><Malignant Melanoma><Malignant Neoplasms><Malignant Tumor><Measures><Mediating><Melanoma><Melanoma Metastasis><Melanoma patient><Mentors><Mentorship><Meta-Analysis><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Melanoma><Metastatic Neoplasm><Metastatic Tumor><Mice><Mice Mammals><Microsatellite Instability><Miscellaneous Antibiotic><Modeling><Molecular Mimicry><Murine><Mus><Myelogenous><Myeloid><Myeloid Cells><Myeloid Differentiation-Inducing Protein><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Neoplasm Metastasis><Nephroid Carcinoma><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><Oncology><Oncology Cancer><Outcome><PD-1 antibody therapy><PD-1 therapy><PD1 antibody therapy><PD1 based treatment><Patients><Phase><Physicians><Plasmacytoma Growth Factor><Position><Positioning Attribute><Probiotics><Receptor Activation><Receptor Signaling><Refractory><Renal Adenocarcinoma><Renal Cell Adenocarcinoma><Renal Cell Cancer><Renal Cell Carcinoma><Research><Resistance><Role><Sampling><Scientist><Secondary Neoplasm><Secondary Tumor><Seminal><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Strains Cell Lines><T Helper Factor><T cell receptor repertoire sequencing><T cell receptor sequencing><T-Cells><T-Lymphocyte><T8 Cells><T8 Lymphocytes><TCR repertoire sequencing><TCR sequencing><TCR-seq><TCRseq><TLR protein><Testing><Tissue Sample><Toll-Like Receptor Family Gene><Toll-like receptors><Tumor Immunity><Veiled Cells><Wild Type Mouse><Work><aCTLA-4><aCTLA-4 antibodies><aCTLA4><aPD-1 therapy><aPD-1 treatment><aPD1 therapy><aPD1 treatment><accessory cell><analyzing longitudinal><anti-CTLA-4><anti-CTLA-4 antibodies><anti-CTLA4><anti-CTLA4 antibodies><anti-PD-1 therapy><anti-PD-1 treatment><anti-PD1 therapy><anti-PD1 treatment><anti-cancer immunotherapy><anti-programmed cell death 1 therapy><anti-programmed cell death protein 1 therapy><anti-tumor immunity><anticancer immunotherapy><antitumor immunity><biological signal transduction><bowel inflammation><cancer immunity><cancer immunotherapy><cancer metastasis><cancer type><career development><check point immunotherapy><check point inhibitor therapy><check point inhibitory therapy><check point therapy><checkpoint immunotherapy><checkpoint inhibitor therapy><checkpoint inhibitory therapy><checkpoint therapy><clinical efficacy><cohort><cultured cell line><cytokine><developmental><digestive tract microbiome><driving><early clinical trial><early phase clinical trial><enteric microbiome><experiment><experimental research><experimental study><experiments><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbiome><gut inflammation><gut microbiome><gut-associated microbiome><immune check point inhibitor><immune check point therapy><immune checkpoint therapy><immune resistance><immune-based cancer therapies><immune-resistant><immunogen><immunogenic><immunoresistance><immunotherapy for cancer><immunotherapy of cancer><improved outcome><inflamed bowel><inflamed gut><inflamed intestine><inflammatory mediator><interferon beta 2><intestinal biome><intestinal inflammation><intestinal microbiome><kidney adenocarcinoma><longitudinal analysis><lymphocyte activating factor><malignancy><microbial><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><mouse model><multidisciplinary><murine model><neoplasm/cancer><next generation><patients suffering from melanoma><patients with melanoma><programmed cell death protein 1 therapy><programs><resistance mechanism><resistant><resistant mechanism><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stool><systemic inflammation><systemic inflammatory response><thymus derived lymphocyte><transplant donor><tumor><tumor cell metastasis><tumor growth><wildtype mouse><α-CTLA-4><α-CTLA4><αCTLA-4><αCTLA4>
View Full Project Details on NIH Reporter
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William Evan Johnson

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 30/100
Very recent
Active award
$210,302
FY 2026

Project Title

Novel Pediatric TB Diagnostics using Host and Microbial Biomarkers

Grant Number:

1R21AI197168-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/17/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT/SUMMARY Tuberculosis (TB) is a leading cause of death in children worldwide, with children contributing to an estimated 14% of global TB deaths and 96% of these deaths being undiagnosed. Children <5 years old have the highest risk of severe disease and mortality and are the most challenging...

Research Terms

<0-11 years old><21+ years old><5 year old><5 years of age><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adult><Adult Human><Age><Airway Disease><Airway infections><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Biological Markers><Biological Testing><Blood><Blood Reticuloendothelial System><Buccal Mucosa><Cause of Death><Cessation of life><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Collection><Communicable Diseases><Concurrent Studies><Country><Data><Death><Detection><Diagnosis><Diagnostic><Diagnostic tests><Disease><Disorder><Dysfunction><Enrollment><Expression Signature><Functional disorder><Funding><Future><Gender><Gene Expression><Gene Expression Profile><Genes><Geography><HIV><Human Immunodeficiency Viruses><Immune><Immune response><Immune system><Immunes><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Infant><Infectious Diseases><Infectious Disorder><Inflammatory><LAV-HTLV-III><Link><Longitudinal Studies><Longitudinal Surveys><Lower Respiratory Tract Infection><Lower respiratory infection><Lung><Lung Respiratory System><Lung TB><Lung Tuberculosis><Lung symptom><Lymphadenopathy-Associated Virus><M tuberculosis infection><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><Malnutrition><Miscellaneous Antibiotic><Molecular><Mouth Mucosa><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><NIH><Nasal><Nasal Mucosa><Nasal Passages Nose><Nasal cavity><Nasopharynx><National Institutes of Health><Nose><Nutritional Deficiency><Oral><Oral Mucosa><Oral mucous membrane structure><Oropharyngeal><Oropharynx><Oropharynxs><Parents><Pathway interactions><Performance><Phenotype><Physiopathology><Play><Proxy><Pulmonary TB><Pulmonary Tuberculosis><RNA Seq><RNA sequencing><RNAseq><Research Specimen><Respiratory Infections><Respiratory System, Nose, Nasal Passages><Respiratory Tract Infections><Rhinopharynx><Role><Sampling><Specimen><Sputum><Structure of mucous membrane of nose><Swab><Symptoms><TB diagnosis><TB diagnostics><TB infection><Techniques><Testing><Tuberculosis><Tuberculosis diagnosis><Uganda><Undernutrition><United States National Institutes of Health><Upper respiratory tract><Virus-HIV><Work><accurate diagnostics><adulthood><age 5><age 5 years><ages><airway immune response><airway microbiome><asthmatic><bio-markers><biologic marker><biomarker><biomarker development><biomarker identification><biomarker validation><blood-based biomarker><blood-based marker><cohort><community microbes><death risk><diagnosed with TB><diagnosed with Tuberculosis><diagnostic biomarker><diagnostic marker><dietary deficiency><differential expression><differentially expressed><disease diagnostic><disseminated TB><disseminated tuberculosis><dysbacteriosis><dysbiosis><dysbiotic><enroll><five year old><five years of age><gene expression pattern><gene expression signature><high risk><host microbe association><host microbe relationship><host microbiome><host response><host-microbe interactions><host-microbial interactions><host-microorganism interactions><identification of biomarkers><identification of new biomarkers><immune system response><immunoresponse><infection due to Mycobacterium tuberculosis><innovate><innovation><innovative><insight><kids><long-term study><longitudinal outcome studies><longitudinal research study><malnourished><marker identification><marker validation><microbe community><microbial><microbial community><microbial composition><microbial consortia><microbial flora><microbial host><microbial imbalance><microbiome><microbiota><microflora><microorganism community><mortality><mortality risk><multispecies consortia><nasopharnygeal><new diagnostics><new marker><next generation diagnostics><non-invasive diagnosis><non-invasive diagnostic><noninvasive diagnosis><noninvasive diagnostic><novel><novel biomarker><novel diagnostics><novel marker><nutrition deficiency><nutrition deficiency disorder><nutritional deficiency disorder><oral mucosae><oral mucosal><oral pharyngeal><parent><pathogen><pathophysiology><pathway><pediatric><point of care><polymicrobial community><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><pulmonary symptom><respiratory immune response><respiratory microbiome><respiratory tract microbiome><social role><tool><transcriptional differences><transcriptional profile><transcriptional signature><transcriptome sequencing><transcriptomic sequencing><transcriptomics><tuberculosis diagnostics><tuberculosis infection><tuberculous spondyloarthropathy><upper airway tract><youngster>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Gregory Robert Dion

UNIVERSITY OF CINCINNATI, CINCINNATI, OH

Exploratory lead · 30/100
Very recent
Active award
$199,872
FY 2026

Project Title

INJECTABLE, TUNABLE CO-DELIVERY THERAPEUTIC IMPLANT TO REDUCE AIRWAY STENOSIS

Grant Number:

5R21EB034840-03

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Laryngeal injury, defined as glottic mucosal ulceration or granulation or subglottic granulation/stenosis, leads to respiratory failure and requires intensive care unit (ICU) admission. More than 55,000 adults are treated daily in ICUs and 13-20 million worldwide require intubation e...

Research Terms

<21+ years old><Abscission><Absorbable Implants><Adjuvant><Adjuvant Therapy><Admission><Admission activity><Adrenal Cortex Hormones><Adult><Adult Human><After Care><After-Treatment><Aftercare><Airway failure><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Autoimmune Diseases><Bacteria><Bacterial Antibiotic Resistance><Bioabsorbable Implants><Biodegradable Implants><Biomechanics><Blood Vessels><Body Tissues><Breathing><Capsules><Cervical><Cicatrix><Clinical><Complex><Corticoids><Corticosteroids><Data><Deglutition><Development><Dexamethasone><Diameter><Disease><Disorder><Domestic Rabbit><Dose><Drug Delivery><Drug Delivery Systems><Drug Implants><Drug Kinetics><Drug usage><Drugs><Dysfunction><Effectiveness><Endotracheal Intubation><Excision><Extirpation><Fibrosis><Foundations><Functional disorder><Geometry><Glucocorticoids><Goals><Histologic><Histologically><Immune reaction><Immune response><Implant><Implantable Drug Delivery Systems><Implantable Infusion Pumps><Implantable Perfusion Pumps><In Vitro><Infection><Inflammatory><Injectable><Injections><Injury><Intensive Care Units><Intratracheal Intubation><Intubation><Investigation><Laryngeal Injury><Laryngeal Trauma><Laser Electromagnetic><Laser Radiation><Lasers><Lesion><Levaquin><Levofloxacin><Light><Measures><Medication><Miscellaneous Antibiotic><Modeling><Mucosa><Mucosal Inflammation><Mucosal Tissue><Mucositis><Mucous Membrane><Operative Procedures><Operative Surgical Procedures><Oryctolagus cuniculus><Outcome><Pathogenesis><Pathological Constriction><Patients><Pharmaceutical Preparations><Pharmacokinetics><Photoradiation><Physiopathology><Postoperative><Postoperative Period><Pre-Clinical Model><Preclinical Models><Procedures><Property><Public Health><Quixin><Rabbits><Rabbits Mammals><Removal><Reoperation><Repeat Surgery><Reporting><Research><Respiratory Aspiration><Respiratory Failure><Respiratory Inspiration><Risk><Role><Scars><Stenosis><Subglottis><Subglottis structure><Submucosa><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Swallowing><System><Technology><Testing><Therapeutic><Therapeutic Implant><Time><Tissues><Trachea><Trachea Proper><Tracheal Stenosis><Tracheostomy><Tracheostomy procedure><Treatment Efficacy><Tube><Ulcer><Ulceration><Upper respiratory tract><Voice><Work><Wound Repair><adjuvant treatment><adulthood><airway epithelium inflammation><airway inflammation><airway microbiome><anti-microbial><antibiotic resistant bacteria><antimicrobial><autoimmune condition><autoimmune disorder><autoimmunity disease><bacterial antibiotic resistant><bacterial resistance to antibiotic><biomechanical><capsule><clinical relevance><clinically relevant><developmental><drug release kinetics><drug release rate><drug use><drug/agent><endotracheal><entire genome><full genome><healing><high risk><host response><immune system response><immunoreaction><immunoresponse><implant design><implantation><improved><in vivo><injuries><innovate><innovation><innovative><inspiration><intervention efficacy><irradiation><microbial consortia><microbial flora><microbiome><microbiome sequencing><microbiota><microflora><minimally invasive><multispecies consortia><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><optical fiber><pathophysiology><post treatment><resection><respiratory><respiratory inflammation><respiratory microbiome><respiratory tract inflammation><respiratory tract microbiome><response><social role><surgery><therapeutic efficacy><therapy efficacy><therapy optimization><tracheal intubation><treatment optimization><treatment strategy><upper airway tract><vascular><whole genome><windpipe><wound healing><wound recovery><wound resolution>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Yoonjee Park

UNIVERSITY OF CINCINNATI, CINCINNATI, OH

Exploratory lead · 30/100
Very recent
Active award
$199,872
FY 2026

Project Title

INJECTABLE, TUNABLE CO-DELIVERY THERAPEUTIC IMPLANT TO REDUCE AIRWAY STENOSIS

Grant Number:

5R21EB034840-03

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Laryngeal injury, defined as glottic mucosal ulceration or granulation or subglottic granulation/stenosis, leads to respiratory failure and requires intensive care unit (ICU) admission. More than 55,000 adults are treated daily in ICUs and 13-20 million worldwide require intubation e...

Research Terms

<21+ years old><Abscission><Absorbable Implants><Adjuvant><Adjuvant Therapy><Admission><Admission activity><Adrenal Cortex Hormones><Adult><Adult Human><After Care><After-Treatment><Aftercare><Airway failure><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Autoimmune Diseases><Bacteria><Bacterial Antibiotic Resistance><Bioabsorbable Implants><Biodegradable Implants><Biomechanics><Blood Vessels><Body Tissues><Breathing><Capsules><Cervical><Cicatrix><Clinical><Complex><Corticoids><Corticosteroids><Data><Deglutition><Development><Dexamethasone><Diameter><Disease><Disorder><Domestic Rabbit><Dose><Drug Delivery><Drug Delivery Systems><Drug Implants><Drug Kinetics><Drug usage><Drugs><Dysfunction><Effectiveness><Endotracheal Intubation><Excision><Extirpation><Fibrosis><Foundations><Functional disorder><Geometry><Glucocorticoids><Goals><Histologic><Histologically><Immune reaction><Immune response><Implant><Implantable Drug Delivery Systems><Implantable Infusion Pumps><Implantable Perfusion Pumps><In Vitro><Infection><Inflammatory><Injectable><Injections><Injury><Intensive Care Units><Intratracheal Intubation><Intubation><Investigation><Laryngeal Injury><Laryngeal Trauma><Laser Electromagnetic><Laser Radiation><Lasers><Lesion><Levaquin><Levofloxacin><Light><Measures><Medication><Miscellaneous Antibiotic><Modeling><Mucosa><Mucosal Inflammation><Mucosal Tissue><Mucositis><Mucous Membrane><Operative Procedures><Operative Surgical Procedures><Oryctolagus cuniculus><Outcome><Pathogenesis><Pathological Constriction><Patients><Pharmaceutical Preparations><Pharmacokinetics><Photoradiation><Physiopathology><Postoperative><Postoperative Period><Pre-Clinical Model><Preclinical Models><Procedures><Property><Public Health><Quixin><Rabbits><Rabbits Mammals><Removal><Reoperation><Repeat Surgery><Reporting><Research><Respiratory Aspiration><Respiratory Failure><Respiratory Inspiration><Risk><Role><Scars><Stenosis><Subglottis><Subglottis structure><Submucosa><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Swallowing><System><Technology><Testing><Therapeutic><Therapeutic Implant><Time><Tissues><Trachea><Trachea Proper><Tracheal Stenosis><Tracheostomy><Tracheostomy procedure><Treatment Efficacy><Tube><Ulcer><Ulceration><Upper respiratory tract><Voice><Work><Wound Repair><adjuvant treatment><adulthood><airway epithelium inflammation><airway inflammation><airway microbiome><anti-microbial><antibiotic resistant bacteria><antimicrobial><autoimmune condition><autoimmune disorder><autoimmunity disease><bacterial antibiotic resistant><bacterial resistance to antibiotic><biomechanical><capsule><clinical relevance><clinically relevant><developmental><drug release kinetics><drug release rate><drug use><drug/agent><endotracheal><entire genome><full genome><healing><high risk><host response><immune system response><immunoreaction><immunoresponse><implant design><implantation><improved><in vivo><injuries><innovate><innovation><innovative><inspiration><intervention efficacy><irradiation><microbial consortia><microbial flora><microbiome><microbiome sequencing><microbiota><microflora><minimally invasive><multispecies consortia><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><optical fiber><pathophysiology><post treatment><resection><respiratory><respiratory inflammation><respiratory microbiome><respiratory tract inflammation><respiratory tract microbiome><response><social role><surgery><therapeutic efficacy><therapy efficacy><therapy optimization><tracheal intubation><treatment optimization><treatment strategy><upper airway tract><vascular><whole genome><windpipe><wound healing><wound recovery><wound resolution>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ran An

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 30/100
Very recent
Active award
$187,715
FY 2026

Project Title

Microbial modulation of mucosal wound healing in the larynx

Grant Number:

5R21DC021012-03

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT ABSTRACT Voice disorders are among the most common communication disorders and estimated to affect 3-9% of Americans annually. These disorders are often associated with laryngeal inflammation secondary to epithelial injuries following phonotrauma, surgical resection, radiation, and various i...

Research Terms

<Abscission><Affect><American><Animals><Antibiotic Therapy><Antibiotic Treatment><Automobile Driving><Autoregulation><Bacteria><Bacteriology><Blood Neutrophil><Blood Plasma Cell><Blood Polymorphonuclear Neutrophil><Body System><Body Tissues><Body part><Causality><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Locomotion><Cell Migration><Cell Movement><Cells><Cellular Migration><Cellular Motility><Cicatrix><Collection><Communication><Communication Disorders><Communication impairment><Communicative Disorders><Complex><Data><Disease><Disorder><Dysphonia><Endothelial Cells><Epithelial Cells><Epithelium><Etiology><Excision><Exposure to><Extirpation><Fibroblasts><Gene Expression><Genes><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><Health><Homeostasis><Human><IgA><Immune><Immune response><Immune system><Immunes><Immunity><Immunoglobulin A><Immunology><Infection><Inflammation><Inflammatory><Injury><Knowledge><Lamina Propria><Laryngeal><Laryngeal Diseases><Laryngeal Disorder><Laryngeal Epithelium><Laryngeal Injury><Laryngeal Mucosa><Laryngeal Trauma><Larynx><Larynx Diseases><Larynx Head and Neck><Longitudinal Studies><Longitudinal Surveys><Macrophage><Maintenance><Marrow Neutrophil><Mature T-Cell><Mature T-Lymphocyte><Measures><Mechanics><Methods><Mice><Mice Mammals><Microbe><Microbiomics><Modeling><Modern Man><Molecular><Mucosa><Mucosal Inflammation><Mucosal Tissue><Mucositis><Mucous Membrane><Mucous body substance><Mucus><Murine><Mus><Mφ><Naphthalene><Natural regeneration><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Operative Procedures><Operative Surgical Procedures><Organ><Organ System><Outcome><Pathogenicity><Performance at work><Phonation Disorders><Physiological Homeostasis><Plasma Cells><Plasmacytes><Play><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Process><Proliferating><QOL><Quality of life><Radiation><Regeneration><Regulation><Removal><Research><Role><Scars><Secondary to><Shapes><Stratified Squamous Epithelium><Structure><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><System><Time><Tissues><Vocal Fold><Voice Disorders><Work><Wound Repair><acute wound><bacterial disease treatment><bacterial infectious disease treatment><causation><cell motility><cell type><cellular differentiation><community microbes><disease causation><driving><dysbacteriosis><dysbiosis><dysbiotic><epithelial injury><epithelial repair><epithelial wound><epithelium regeneration><functional group><healing><host microbe association><host microbe relationship><host microbiome><host microbiota><host microflora><host response><host-microbe interactions><host-microbial interactions><host-microorganism interactions><immune system response><immunoresponse><improved><inflammation marker><inflammatory marker><injured><injuries><injury and repair><injury to tissue><innovate><innovation><innovative><job performance><larynx disorder><long-term study><longitudinal outcome studies><longitudinal research study><mechanic><mechanical><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome research><microbiome science><microbiome studies><microbiota><microflora><microorganism community><migration><model organism><mucous><multispecies consortia><neutrophil><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><plasmocyte><polymicrobial community><probiotic therapeutic><probiotic therapy><probiotic treatment><programs><protein expression><regenerate><regenerate epithelium><repair><repaired><resection><resident microbes><resident microflora><response><social communication><social role><surgery><tissue injury><tissue wound><treatment strategy><vocal cord><vocalis><vocalis muscle><voice box><work performance><wound><wound healing><wound recovery><wound resolution><wounding><wounds>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Tengteng Wang

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 30/100
Very recent
Active award
$170,930
FY 2026

Project Title

Longitudinal Dynamics of Blood Microbiome and Circulating Tumor Cell in Metastatic Breast Cancer

Grant Number:

1R03CA308463-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Metastatic breast cancer (mBC) is one of the most devastating diseases. More than 40,000 deaths in the U.S. each year are caused by breast cancer distant metastasis. Triple-negative breast cancer (TNBC) is the most aggressive mBC subtype, with a median overall survival of on...

Research Terms

<Active Follow-up><Address><After Care><After-Treatment><Aftercare><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Bacteria><Biological><Biological Markers><Biomass><Biopsy Sample><Biopsy Specimen><Blood><Blood Circulation><Blood Plasma><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Bloodstream><Body Tissues><Breast><Breast Cancer><Breast Cancer Patient><Breast Tumor Patient><Cancer Cause><Cancer Etiology><Cancer Patient><Cancer Prognosis><Cancer Treatment><Cancers><Cell Body><Cell Count><Cell Number><Cells><Cellular Matrix><Cessation of life><Characteristics><Clinical><Clinical Research><Clinical Study><Coupled><Cytoskeletal System><Cytoskeleton><DNA><DNA seq><DNA sequencing><DNAseq><Data Discovery><Data Set><Death><Demographic Factors><Deoxyribonucleic Acid><Development><Disease><Disease Progression><Disease stratification><Disorder><Distant Cancer><Distant Metastasis><ERBB2><ERBB2 gene><Epithelium><General Prognostic Factor><General Taxonomy><Goals><HER -2><HER-2><HER2><HER2 Genes><HER2/neu><Human><Human Microbiome><Immune><Immunes><Incidence><Intermediary Metabolism><Literature><Machine Learning><Malignant Breast Neoplasm><Malignant Melanoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Medical><Melanoma><Mesenchymal><Metabolic Processes><Metabolism><Metastasis><Metastasis Induction><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Metastatic breast cancer><Methods><Microbe><Microbiomics><Modern Man><Monitor><Morbidity><NEU Oncogene><NEU protein><Nature><Neoplasm Circulating Cells><Neoplasm Metastasis><Oncogene ErbB2><Outcome><Pathologic><Pathway interactions><Patients><Plasma><Plasma Serum><Population Study><Precision therapeutics><Prognosis><Prognostic Factor><Prognostic Marker><Prognostic/Survival Factor><Progression-Free Survivals><Research><Research Resources><Resistance><Resolution><Resources><Reticuloendothelial System, Serum, Plasma><Risk><Role><Sampling><Secondary Neoplasm><Secondary Tumor><Site><Sterility><Survival Rate><TKR1><TNBC><Taxonomy><Techniques><Testing><Time><Tissue Sample><Tissues><Travel><Treatment Efficacy><Tumor Cell><Universities><Validation><Virus><Woman><active followup><analyzing longitudinal><anti-cancer therapy><bio-markers><biologic><biologic marker><biomarker><blood treatment><breast cancer progression><burden of disease><burden of illness><c-erbB-2><c-erbB-2 Genes><c-erbB-2 Proto-Oncogenes><cancer metastasis><cancer sub-types><cancer subtypes><cancer therapy><cancer type><cancer-directed therapy><chemotherapy><circulating neoplastic cell><circulating tumor cell><cohort><community microbes><computer based prediction><death risk><developmental><disease burden><erbB-2 Genes><fecal sample><follow up><follow-up><followed up><followup><fungus><herstatin><human DNA><human-associated microbiome><individuals with breast cancer><innovate><innovation><innovative><intervention efficacy><intracellular skeleton><liquid biopsy><longitudinal analysis><machine based learning><machine learning based model><machine learning model><malignancy><malignant breast tumor><metagenome sequencing><metagenomic sequencing><metastatic breast tumor><metastatic mammary cancer><metastatic mammary tumor><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial signature><microbiome><microbiome research><microbiome science><microbiome sequencing><microbiome signature><microbiome studies><microbiota><microflora><microorganism community><mortality><mortality risk><multispecies consortia><neoplasm/cancer><neoplastic cell><neu Genes><novel><outcome prediction><pathway><patient population><patients with breast cancer><person with breast cancer><polymicrobial community><population research study><population survey><population-based study><population-level study><post treatment><precision therapies><precision treatment><predict clinical outcome><predictive modeling><prognostic biomarker><prognostic indicator><resistance to therapy><resistant><resistant to therapy><resolutions><response to therapy><response to treatment><social role><sterile><stool sample><stool specimen><therapeutic efficacy><therapeutic resistance><therapeutic response><therapy efficacy><therapy resistant><therapy response><treatment and outcome><treatment resistance><treatment response><treatment responsiveness><triple-negative breast cancer><triple-negative invasive breast carcinoma><tumor><tumor cell metastasis><tumor microbiome><tumor-associated microbiome><validations>
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Stephanie Maree Dillon

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 30/100
Very recent
Active award
$156,000
FY 2026

Project Title

Gut Check: The Impact of Gut Bacteria on Physical Function in Older Adults with and without HIV

Grant Number:

1R03AG094334-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT. Physical function refers to an individual's ability to perform daily tasks and activities and is a crucial aspect of overall health. Maintenance of physical function is the cornerstone of successful aging with declines in physical function associated with increased risk of hospitalization,...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><21+ years old><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Activities of Daily Living><Activities of everyday life><Address><Adult><Adult Human><Age><Aging><Algorithms><Bacteria><Bacterial Genes><Biological Markers><Causality><Chronic Disease><Chronic Illness><Cohort Studies><Complex><Cross Sectional Analysis><Data><Development><Disease><Disorder><Etiology><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genes><Goals><HIV><HIV disease status><HIV individuals><HIV infected individuals><HIV infected persons><HIV infection status><HIV people><HIV positive individuals><HIV positive people><HIV serostatus><HIV status><HIV-1><HIV-I><HIV1><HIV1 infection status><HIV1 status><Health><Health Promotion><Hospital Admission><Hospitalization><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Impairment><Individual><Inflammatory><Institutionalization><Intervention><Investigation><Knowledge><LAV-HTLV-III><Link><Literature><Lymphadenopathy-Associated Virus><Maintenance><Measurement><Measures><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Older Population><Outcome><Output><PLWH><PWH><Participant><Pathway interactions><Pattern><Persons><Physical Function><Physiologic><Physiological><Pilot Projects><Play><Polypharmacy><Population><Premature Mortality><Production><Public Health><Regulation><Reporting><Risk><Role><Salutogenesis><Sample Size><Specificity><Syndrome><Time><Virus-HIV><Visit><Woman><Work><adulthood><age associated decline><age associated difference><age based difference><age dependent decline><age dependent difference><age dependent variation><age difference><age related decline><age related difference><age related variation><age specific difference><ages><bacteria in the gut><bacteria pathogen><bacterial community><bacterial pathogen><bio-markers><biologic marker><biomarker><causation><chronic disorder><clinical relevance><clinically relevant><co-morbid><co-morbidity><cohort><cohort research study><cohort survey><comorbidity><cost><cost effective><daily living function><daily living functionality><decline with age><design><designing><developmental><differ by age><difference across age><difference in age><digestive tract microbiome><disease causation><dysbacteriosis><dysbiosis><dysbiotic><enhance healthspan><enteric microbial community><enteric microbiome><enteric microbiota><experience><extend healthspan><extending healthy lifespan><fecal microbiome><frailty><functional ability><functional capacity><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut community><gut dysbiosis><gut flora><gut health><gut homeostasis><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><healthspan extension><improve healthspan><improved><increase healthspan><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><men><microbial><microbial imbalance><microbiome><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><novel><older adult><older adulthood><older groups><older individuals><older person><pathobiont><pathogenic bacteria><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><pilot study><prevent><preventing><prolong healthspan><promote healthspan><promoting health><sedentary><sex><social role><stool microbiome><stool-associated microbiome><variation by age>
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Lucas R Hoffman

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 30/100
Recent
Active award
Career award
$125,068
FY 2026

Project Title

Patient-oriented microbiome and advanced culture approaches to identifying the microbial determinants of chronic pediatric disease

Grant Number:

5K24HL141669-08

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/22/2018

End Date:

12/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT This K24 renewal proposes salary and research support for Lucas Hoffman, MD, PhD to continue to spend at least 25% of his time mentoring students, fellows, and junior faculty in patient-oriented research (POR) on the microbial determinants of chronic, pediatric diseases. Thi...

Research Terms

<0-11 years old><21+ years old><Adult><Adult Human><Advisory Committees><Age><Airway Fibrosis><Airway infections><Airway scar><Alimentary Canal><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Bile Acids><Biological><Biological Markers><Bionomics><Body System><Bronchioalveolar Lavage><Bronchoalveolar Lavage><Bronchopulmonary Lavage><CF lung disease><CFTR><CFTR Protein><Caring><Child><Child Youth><Childhood><Children (0-21)><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Data><Clinical Research><Clinical Study><Collaborations><Communicable Diseases><Computer Analysis><Core Facility><Cystic Fibrosis><Cystic Fibrosis Transmembrane Conductance Regulator><Data><Detectable Residual Disease><Development><Development and Research><Digestive Tract><Discipline><Disease><Disorder><Doctor of Philosophy><Drugs><Ecology><Enrollment><Environment><Faculty><Failure><Fellowship><Funding><Future><GI Tract><GI microbiome><Gastroenterology><Gastrointestinal Diseases><Gastrointestinal Tract><Gastrointestinal tract structure><Genetic Diseases><Goals><IRB><IRBs><Impairment><Infant><Infectious Diseases><Infectious Disorder><Infrastructure><Inhalation><Inhaling><Institutional Review Boards><Investigators><Laboratories><Leadership><Link><Lower respiratory tract structure><Lung Lavage><Malabsorption Syndromes><Measures><Medication><Medicine><Mentors><Mentorship><Methods><Microbiologic Technic><Microbiologic Techniques><Microbiological Technics><Microbiological Techniques><Microbiology><Minimal Residual Disease><Miscellaneous Antibiotic><Molecular><Morbidity><Mucoviscidosis><Multi-center studies><Multicenter Studies><Nutrient><Nutrition><Nutritional><Observational Study><Organ><Organ System><Oropharyngeal><Oropharynx><Oropharynxs><Outcome><Parents><Participant><Pathogenesis><Patients><Persons><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D.><Ph.D. student><PhD><PhD student><PhD. student><Pharmaceutical Preparations><Physicians><Pneumology><Pneumonology><Process><Productivity><Program Development><Proteins><Proxy><Pulmonary Cystic Fibrosis><Pulmonary Medicine><Pulmonology><R & D><R&D><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Support><Researchers><Residual Neoplasm><Residual Tumors><Resources><Respiratory Infections><Respiratory Tract Infections><Respiratory fibrosis><Salaries><Sampling><Scientist><Sputum><Students><Study Subject><System><Task Forces><Testing><Time><Training><Translational Research><Translational Research Enterprise><Translational Science><Universities><Upper respiratory tract><Visit><Wages><Washington><Work><adulthood><advisory team><ages><airway microbiome><alimentary tract><analyze microbiome><bacterial disease treatment><bacterial infectious disease treatment><bench-to-bedside translation><bio-markers><biologic><biologic marker><biomarker><bronchiolar alveolar lavage><bronchopulmonary lavage therapy><career><chronic disorder><clinical center><computational analyses><computational analysis><computer analyses><cystic fibrosis lung><cystic fibrosis lung disease><cystic fibrosis transmembrane regulator><developmental><digestive canal><digestive tract microbiome><doctoral student><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><effective therapy><effective treatment><enroll><enteric microbiome><experience><fecal metabolome><fecal microbiome><fecal sample><gastrointestinal><gastrointestinal absorption disorder><gastrointestinal disorder><gastrointestinal function><gastrointestinal microbiome><genetic condition><genetic disorder><gut microbiome><gut-associated microbiome><improved><interest><intestinal biome><intestinal malabsorption><intestinal microbiome><kids><lower respiratory tract><malabsorption><metabolome><metabonome><microbial><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome analysis><microbiome sequencing><microbiota><microflora><mortality><multispecies consortia><novel><nutritious><observational research study><observational survey><oral pharyngeal><oronasal swab><oropharyngeal swab><parent><pathogen><patient centered><patient oriented><patient oriented research><patient oriented study><pediatric><programs><research and development><residual disease><respiratory><respiratory microbiome><respiratory tract microbiome><response><skills><stool microbiome><stool sample><stool specimen><stool-associated microbiome><student mentoring><student training><student-led learning><training opportunity><translation research><translation research enterprise><translational investigation><translational research program><upper airway tract><youngster>
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Richard Tobin

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 26/100
Solid budget
Active award
$356,850
FY 2026

Project Title

MAIT cell: microbiome crosstalk in antitumor immunity

Grant Number:

5R37CA279604-03

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

11/30/2028

Project Abstract

PROJECT SUMMARY The composition of microorganisms that inhabit the gut, known as the gut microbiome, has been strongly associated with the pathogenesis of several diseases including cancer, diabetes, and multiple sclerosis. Notably, several high-profile studies have reported that the composition of ...

Research Terms

<Accounting><Address><Anabolism><Antibiotic Therapy><Antibiotic Treatment><Antigens><Bacteria><Binding><CD152><CD152 Antigen><CD152 Gene><CTLA 4><CTLA-4 Gene><CTLA4><CTLA4 gene><CTLA4-TM><Cancer Patient><Cancers><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Checkpoint inhibitor><Clinical><Cytotoxic T-Lymphocyte Protein 4><Cytotoxic T-Lymphocyte-Associated Antigen 4><Cytotoxic T-Lymphocyte-Associated Protein 4><Cytotoxic T-Lymphocyte-Associated Serine Esterase-4><Data><Development><Diabetes Mellitus><Disease><Disorder><Disseminated Sclerosis><Frequencies><GI microbiome><Human><Immune><Immune Targeting><Immune checkpoint inhibitor><Immune mediated therapy><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologically Directed Therapy><Immunologics><Immunotherapy><In Vitro><Inflammation><Intermediary Metabolism><Link><Lytotoxicity><Malignant Melanoma><Malignant Neoplasms><Malignant Tumor><Melanoma><Melanoma Cell><Melanoma Tumor><Melanoma patient><Messenger RNA><Metabolic Processes><Metabolism><Mice><Mice Mammals><Microbe><Modality><Modern Man><Molecular Interaction><Mucosa><Mucosal Tissue><Mucous Membrane><Multiple Sclerosis><Murine><Mus><Outcome><PBMC><PD 1><PD-1><PD-1 antibody><PD-1 antibody therapy><PD-1 therapy><PD1><PD1 antibody><PD1 antibody therapy><PD1 based treatment><Pathogenesis><Pathway interactions><Patients><Peripheral Blood Mononuclear Cell><Play><Population><Production><Reporting><Research><Riboflavin><Role><Sampling><Site><Subcellular Process><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cells><T-Lymphocyte><T-cell therapeutics><T-cell transfer therapy><Testing><Therapeutic><Tumor Cell><Tumor Immunity><Tumor growth in melanoma><Vitamin B 2><Vitamin B2><Vitamin G><Vitamins><Wild Type Mouse><aPD-1><aPD-1 therapy><aPD-1 treatment><aPD1><aPD1 therapy><aPD1 treatment><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><anti programmed cell death 1><anti-PD-1><anti-PD-1 Ab><anti-PD-1 antibodies><anti-PD-1 monoclonal antibodies><anti-PD-1 therapy><anti-PD-1 treatment><anti-PD1><anti-PD1 Ab><anti-PD1 antibodies><anti-PD1 monoclonal antibodies><anti-PD1 therapy><anti-PD1 treatment><anti-melanoma immunity><anti-programmed cell death 1 therapy><anti-programmed cell death protein 1><anti-programmed cell death protein 1 antibodies><anti-programmed cell death protein 1 therapy><anti-programmed death-1 antibody><anti-tumor immunity><antiPD-1><antitumor immunity><bacteria in the gut><bacterial disease treatment><bacterial infectious disease treatment><biosynthesis><cancer immunity><cancer microenvironment><cancer type><cell killing><check point immunotherapy><check point inhibitor therapy><check point inhibitory therapy><check point therapy><checkpoint immunotherapy><checkpoint inhibitor therapy><checkpoint inhibitory therapy><checkpoint therapy><cytokine><cytotoxic><cytotoxic T-lymphocyte antigen 4><cytotoxicity><defined contribution><developmental><diabetes><digestive tract microbiome><enteric microbiome><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbiome><germ free condition><gut bacteria><gut microbes><gut microbial species><gut microbiome><gut-associated microbiome><immune check point inhibitor><immune check point therapy><immune checkpoint therapy><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immunity against melanoma><immuno therapy><immunogen><improved><improved outcome><in vivo Model><insular sclerosis><intestinal biome><intestinal microbes><intestinal microbiome><mRNA><malignancy><microbial><microbial products><microbiome><microorganism><mouse model><murine model><neoplasm/cancer><neoplastic cell><novel><pathway><patient response><patient specific response><patients suffering from melanoma><patients with melanoma><programmed cell death 1><programmed cell death protein 1><programmed cell death protein 1 therapy><programmed death 1><recruit><response><response to therapy><response to treatment><responsive patient><sle2><social role><specific pathogen free><systemic lupus erythematosus susceptibility 2><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic T-cell platform><therapeutic response><therapy response><thymus derived lymphocyte><transplant therapy><transplant treatment><transplantation therapy><transplantation treatment><treatment response><treatment responsiveness><tumor><tumor microenvironment><wildtype mouse><αPD-1><αPD1>
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Taryn Broe

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 24/100
Training-friendly
$13,980
FY 2026

Project Title

Identifying the Drivers and Consequences ofHost-Microbiome Composition and Function

Grant Number:

5F31GM156042-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2024

End Date:

12/31/2025

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Microbiomes are crucial to the physiological functioning of host organisms. Understanding what regulates microbiome assembly and function can therefore have critical implications for host health. The central hypothesis of this proposal is that host phylogenetics is a key driver of mi...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Address><Affect><Algae><Bacteria><Bioavailability><Biologic Models><Biological Availability><Biological Models><Carbon><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Morphology><Cellular Physiology><Cellular Process><Cellular Stress><Cellular Stress Response><Characteristics><Communities><Data><Diet><Disease><Disorder><Distant><Eating><Ecologic Systems><Ecological Systems><Ecosystem><Environment><Esters><Eukaryota><Eukaryote><Evolution><Fatty Acids><Feeds><Food><Food Intake><Fresh Water><Freshwater><Functional Metagenomics><Gastrointestinal Diseases><General Taxonomy><Genetic><Health><History><Hominidae><Hominids><Human><Hydrogen Oxide><Knowledge><Life><Lipids><Measurement><Measures><Membrane><Metagenomics><Microbe><Model System><Modern Man><Mucous body substance><Mucus><Neurodevelopmental Disorder><Neurological Development Disorder><Nitrogen><Nutrient><Nutritional><Organism><Phosphorous><Phosphorus><Phylogenetic Analysis><Phylogenetics><Phylogeny><Physiologic><Physiologic Availability><Physiological><Physiology><Phytoplankton><Plants><Play><Pongidae><Population><Prokaryotae><Prokaryotic Cells><Recording of previous events><Regulation><Ribosomal RNA><Role><Sampling><Shotgun Sequencing><Shotguns><Skin><Specificity><Subcellular Process><Taxonomy><Testing><Translating><Transplantation><Vitamins><Water><Work><Zooplankton><cell morphology><cell stress><climate change><climatic changes><community microbes><diets><expectation><experiment><experimental research><experimental study><experiments><fitness><gastrointestinal disorder><global climate change><great ape><histories><host microbiome><insight><living system><membrane structure><microbe community><microbial><microbial community><microbiome><microbiome community><microbiome community composition><microbiome composition><microbiome intervention><microbiome species composition><microbiome structure><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microorganism community><mucous><neurodevelopmental disease><nutrient requirement><nutritious><polymicrobial community><prokaryote><rRNA><recruit><response><sample archive><shot gun><social role><trait><transplant>
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Pamela K Den Besten

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 22/100
Recent
Active award
$246,000
FY 2026

Project Title

Effects of the oral microbiome on Adverse Outcomes of Pediatric Hematopoietic Cell Transplantation

Grant Number:

5R21DE035002-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/8/2025

End Date:

3/31/2027

Project Abstract

ABSTRACT: Dental clearance, to assure the absence of dental caries, is a routine process prior undergoing hematopoietic cell transplant (HCT). Dental caries is one of the most prevalent childhood diseases worldwide, affecting 25-50% of children in the United States, and in preliminary and published ...

Research Terms

<0-11 years old><Admission><Admission activity><Adverse effects><Affect><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Bacteria><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Blood><Blood Circulation><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Bloodstream><Bone Grafting><Bone Marrow Grafting><Bone Marrow Transplant><Bone Marrow Transplantation><Bone Transplantation><Buccal Cavity><Buccal Cavity Head and Neck><Caries><Cavitas Oris><Cell Transplantation><Cellular Immune Function><Chemotherapy and Radiation><Chemotherapy and/or radiation><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Clinical><Communities><Complex><Conditioning Therapy><Data Scientist><Dental><Dental Decay><Dental caries><Development><Disease><Disorder><Drugs><Fever><Foundations><Functional Metagenomics><General Taxonomy><Goals><HSC transplantation><Health><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Incidence><Interdisciplinary Research><Interdisciplinary Study><Life><Location><Malignant><Malignant - descriptor><Marrow Transplantation><Medication><Metabolic><Metagenomics><Microbe><Miscellaneous Antibiotic><Morbidity><Mouth><Mouth microbiome><Mucosal Inflammation><Mucositis><Multidisciplinary Collaboration><Multidisciplinary Research><Non-Malignant><Oral><Oral cavity><Organism><Outcome><Pediatric Hospitals><Pharmaceutical Preparations><Process><Property><Publishing><Pyrexia><QOL><Quality of life><Recovery><Regimen><Reporting><Resistance><Resolution><Risk><Risk Factors><Saliva><Sampling><Scientist><Shotguns><Taxonomy><Testing><Time><Transplant Recipients><Transplantation><Transplantation Conditioning><Treatment outcome><United States><Virus><Vulnerable Populations><Work><adverse consequence><adverse outcome><alter microbiome><behavior intervention><behavioral intervention><blood infection><blood stem cell transplantation><bloodstream infection><bone transplant><cariogenic biofilm><cellular transplant><chemo/radiation therapy><chemotherapy><chemotherapy and radiotherapy><child patients><childhood cancer survivor><co-morbid><co-morbidity><comorbidity><conditioning><curative intervention><curative therapeutic><curative therapy><curative treatments><dental biofilm><dental transplantation><developmental><drug/agent><febrile><febris><fungus><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><immune function><infection in the blood><infection of the blood><insight><kids><living system><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><microorganism><mortality><nonmalignant><oral bacteria><oral care><oral flora><oral microbiome><pediatric><pediatric cancer survivor><pediatric patients><plaque biofilm><post-transplant><post-transplantation><posttransplant><posttransplantation><programs><radiation or chemotherapy><rational design><recruit><resistant><resolutions><shot gun><success><tooth decay><tooth surface><transplant><transplant patient><transplant therapy><transplant treatment><transplantation therapy><transplantation treatment><vulnerable group><vulnerable individual><vulnerable people><youngster>
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Susan Veronica Lynch

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 22/100
Recent
Active award
$246,000
FY 2026

Project Title

Effects of the oral microbiome on Adverse Outcomes of Pediatric Hematopoietic Cell Transplantation

Grant Number:

5R21DE035002-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/8/2025

End Date:

3/31/2027

Project Abstract

ABSTRACT: Dental clearance, to assure the absence of dental caries, is a routine process prior undergoing hematopoietic cell transplant (HCT). Dental caries is one of the most prevalent childhood diseases worldwide, affecting 25-50% of children in the United States, and in preliminary and published ...

Research Terms

<0-11 years old><Admission><Admission activity><Adverse effects><Affect><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Archaea><Archaebacteria><Archaeobacteria><Archaeon><Bacteria><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Blood><Blood Circulation><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Bloodstream><Bone Grafting><Bone Marrow Grafting><Bone Marrow Transplant><Bone Marrow Transplantation><Bone Transplantation><Buccal Cavity><Buccal Cavity Head and Neck><Caries><Cavitas Oris><Cell Transplantation><Cellular Immune Function><Chemotherapy and Radiation><Chemotherapy and/or radiation><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Clinical><Communities><Complex><Conditioning Therapy><Data Scientist><Dental><Dental Decay><Dental caries><Development><Disease><Disorder><Drugs><Fever><Foundations><Functional Metagenomics><General Taxonomy><Goals><HSC transplantation><Health><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Incidence><Interdisciplinary Research><Interdisciplinary Study><Life><Location><Malignant><Malignant - descriptor><Marrow Transplantation><Medication><Metabolic><Metagenomics><Microbe><Miscellaneous Antibiotic><Morbidity><Mouth><Mouth microbiome><Mucosal Inflammation><Mucositis><Multidisciplinary Collaboration><Multidisciplinary Research><Non-Malignant><Oral><Oral cavity><Organism><Outcome><Pediatric Hospitals><Pharmaceutical Preparations><Process><Property><Publishing><Pyrexia><QOL><Quality of life><Recovery><Regimen><Reporting><Resistance><Resolution><Risk><Risk Factors><Saliva><Sampling><Scientist><Shotguns><Taxonomy><Testing><Time><Transplant Recipients><Transplantation><Transplantation Conditioning><Treatment outcome><United States><Virus><Vulnerable Populations><Work><adverse consequence><adverse outcome><alter microbiome><behavior intervention><behavioral intervention><blood infection><blood stem cell transplantation><bloodstream infection><bone transplant><cariogenic biofilm><cellular transplant><chemo/radiation therapy><chemotherapy><chemotherapy and radiotherapy><child patients><childhood cancer survivor><co-morbid><co-morbidity><comorbidity><conditioning><curative intervention><curative therapeutic><curative therapy><curative treatments><dental biofilm><dental transplantation><developmental><drug/agent><febrile><febris><fungus><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><immune function><infection in the blood><infection of the blood><insight><kids><living system><metagenome sequencing><metagenomic sequencing><microbial><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><microorganism><mortality><nonmalignant><oral bacteria><oral care><oral flora><oral microbiome><pediatric><pediatric cancer survivor><pediatric patients><plaque biofilm><post-transplant><post-transplantation><posttransplant><posttransplantation><programs><radiation or chemotherapy><rational design><recruit><resistant><resolutions><shot gun><success><tooth decay><tooth surface><transplant><transplant patient><transplant therapy><transplant treatment><transplantation therapy><transplantation treatment><vulnerable group><vulnerable individual><vulnerable people><youngster>
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Sonia Kupfer

UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 22/100
Recent
Active award
$191,675
FY 2026

Project Title

Colonic bile acid metabolism and responses in African Americans and non-Hispanic Whites

Grant Number:

5R21CA280578-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/13/2024

End Date:

11/30/2026

Project Abstract

African Americans (AA) have among the highest colorectal cancer (CRC) incidence and mortality in the US. Environmental factors influenced by social factors, especially high fat diets, are known to increase CRC risk, but how these factors contribute to CRC risk differences is largely unknown. Bile ac...

Research Terms

<African><African American><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><Age><American><Apoptosis><Apoptosis Pathway><Area><Ascending colon><Attention><Bacteria><Bile Acids><Biological Markers><Biopsy><Blood Serum><Body Tissues><Cancers><Cellular Assay><Chicago><Clinical><Colon><Colon Cancer><Colon Carcinoma><Colorectal Cancer><Data><Deoxycholic Acid><Desoxycholic Acid><Diagnostic><Diet><Dietary Fats><Dihydroxycholanoic Acid><Environment><Environmental Factor><Environmental Risk Factor><Epithelium><Ethnic Origin><Ethnicity><European><Fats><Fatty acid glycerol esters><Feces><Functional Metagenomics><Future><GI microbiome><Gene Transcription><Genetic Transcription><Genotype><Goals><Hand><Hepatic><Hepatic Flexture><High Fat Diet><Host Factor><Host Factor Protein><Human><Incidence><Individual><Integration Host Factors><Intermediary Metabolism><Investigation><Isolithocholic Acid><Linear Regressions><Lithocholic Acid><Malignant Neoplasms><Malignant Tumor><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Metabolic Processes><Metabolism><Metagenomics><Microbiomics><Modern Man><Neighborhoods><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Organoids><Participant><Pathway interactions><Phenotype><Population><Population Control><Population Heterogeneity><Position><Positioning Attribute><Prevention><Prevention trial><Production><Programmed Cell Death><Proliferating><Prospective Studies><Prospective cohort><Prospective, cohort study><RNA Expression><Role><Sampling><Secondary to><Serum><Testing><Tissues><Transcription><Translating><Validation><Work><ages><bile acid metabolism><bile metabolism><bio-markers><biologic marker><biomarker><burden of disease><burden of illness><cancer in the colon><carcinogenicity><cell assay><colon cancer tumorigenesis><colon carcinogenesis><colon tumorigenesis><colorectal cancer risk><colorectal carcinogenesis><colorectal tumorigenesis><dehydroxylation><demographics><deprivation><dietary lipid><diets><digestive tract microbiome><disease burden><diverse populations><enteric microbiome><environmental risk><epigenomics><experience><fecal sample><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><hands><heterogeneous population><individualized prevention><innovate><innovation><innovative><intestinal biome><intestinal microbiome><malignancy><microbial><microbiome><microbiome research><microbiome science><microbiome studies><mortality><multi-ethnic><multiethnic><neoplasm/cancer><pathway><personalized prevention><population diversity><precision prevention><primary outcome><prospective research study><prospective survey><response><secondary outcome><sex><social factors><social influence><social role><stool><stool sample><stool specimen><success><surveillance study><validations><western diet><western-style diet><western-type diet>
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Tengteng Wang

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 16/100
Active award
$248,930
FY 2026

Project Title

Identifying the role of the gut microbiome in the etiology of benign breast disease

Grant Number:

5R00CA267557-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT The overall goal of this project is to identify the role of the gut microbiome in the etiology of benign breast disease (BBD), and thereby shed light on its pathogenesis in relation to breast cancer. Approximately one out of every five women in the United States has been dia...

Research Terms

<16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Age><Age at Menarche><Applications Grants><Attention><Autoregulation><Award><Bacteria><Bacteroides><Benign><Bioinformatics><Biopsy><Breast><Breast Cancer><Breast Cancer Epidemiology><Breast Cancer Prevention><Breast Diseases><Breast Disorder><Breast biopsy><Cancer Cause><Cancer Etiology><Catalogs><Causality><Classification><Collaborations><Collection><Data><Data Analyses><Data Analysis><Data Set><Development><Diagnosis><Endocrine Gland Secretion><Environment><Estrogens><Etiology><Event><Exogenous Hormone Therapy><Exogenous Hormone Use><Feces><First Births><Fostering><Functional Metagenomics><Future><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Taxonomy><Goals><Grant Proposals><High Risk Woman><Homeostasis><Hormonal><Hormonal Risk Factor><Hormones><Hospitals><Human Microbiome><Intermediary Metabolism><Investigators><Knowledge><Lesion><Link><Liquid Chromatography><Malignant Breast Neoplasm><Measurement><Mediating><Mentors><Metabolic Processes><Metabolism><Metagenomics><Methods><Microbiomics><Morbidity><Multiomic Data><Nested Case-Control Study><Nulliparas><Nulliparity><Nulliparous><Nurses><Nurses' Health Study><Oral Contraceptives><Participant><Pathogenesis><Pathologic><Pathologist><Pathology><Pathway interactions><Physiological Homeostasis><Play><Predicting Risk><Productivity><Proliferative Breast Disease><Proliferative Breast Lesion><Proliferative Fibrocystic Change><Proliferative Type Breast Fibrocystic Change><Prospective Studies><Reporting><Reproductive Factors><Reproductive History><Reproductive History Epidemiology><Reproductive Issues><Research><Research Personnel><Researchers><Retrospective Studies><Risk><Risk Factors><Risk Reduction><Role><Sample Size><Shotguns><Strategic vision><Systematics><Taxonomy><Testing><Therapeutic Estrogen><Therapeutic Hormone><Tissue Sample><Training><United States><Variant><Variation><Woman><Women's mortality><Women's study><ages><at-risk females><at-risk women><benign proliferative breast disease><biomedical scientist><birth control pill><breast pathology><career><catalog><causation><cohort><community microbes><data interpretation><death among females><death among women><death in females><death in women><developmental><digestive tract microbiome><disease causation><disease diagnosis><disease epidemiology><disease risk><disease subgroups><disease subtype><disorder risk><disorder subtype><enteric microbial community><enteric microbiome><enteric microbiota><experience><fecal microbiome><fecal sample><female death><female mortality><female study><females at high risk><forecasting risk><gastrointestinal microbial flora><gastrointestinal microbiome><gut community><gut flora><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><high risk><high risk females><human-associated microbiome><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbes><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><malignant breast tumor><mammary cancer prevention><mammary disorder><mammary tumor prevention><menopausal hormone therapy><menopausal hormone treatment><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metagenome sequencing><metagenomic sequencing><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial signature><microbiome><microbiome community composition><microbiome composition><microbiome intervention><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microbiota derived metabolites><microbiota metabolites><microflora><microorganism community><mortality><mortality among females><mortality among women><mortality in females><mortality in women><multidisciplinary><multiomics><multiple omic data><multiple omics><multispecies consortia><novel><nurse><panomics><pathway><polymicrobial community><precancer><precancerous><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><premalignant><prevent breast cancer><programs><prospective><prospective research study><prospective survey><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><reproductive><retrospective research study><retrospective survey><risk prediction><risk predictions><risk-reducing><sample collection><shot gun><small molecule><social role><specimen collection><stool><stool microbiome><stool sample><stool specimen><stool-associated microbiome><study among females><study among women><study in females><study in women><study on females><study on women><study within women><tandem mass spectrometry><women at high risk><women's death>
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Snehal N. Chaudhari

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 16/100
Active award
$235,721
FY 2026

Project Title

Elucidating the role of the microbiome in inducing gut permeability and inflammation

Grant Number:

5R00DK128503-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2026

Project Abstract

Project Summary/Abstract Background – The microbiome affects host metabolism predominantly via metabolites synthesized or modified by gut bacteria. The identity of these metabolites and their mechanisms of action in the host remain largely unknown. Overarching metabolomic analyses have offered a gli...

Research Terms

<Acute><Affect><Assay><Attention><Automobile Driving><Autoregulation><Bacteria><Basal Transcription Factor><Basal transcription factor genes><Bile><Bile Acids><Bile Juice><Bile fluid><Binding Sites><Bioassay><Biochemical><Bioinformatics><Biological Assay><Biopsy><CRISPR><CRISPR/Cas system><Carbon><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chronic><Cirrhosis><Clustered Regularly Interspaced Short Palindromic Repeats><Collaborations><Colon><Combining Site><Common Rat Strains><Country><Coupled><Data><Development><Disease><Disorder><Epithelial Cells><Extracellular Signal-Regulated Kinase Gene><Fatty Liver><Feces><Folate><Folate fortification><Folic Acid><Folic acid fortification><Functional Metagenomics><Gene Transcription><General Hospitals><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genetic><Genetic Transcription><Germ-Free><Goals><Growth><Gut Epithelial Permeability><Gut Epithelium><Gut Hyperpermeability><Gut permeability><Health><Hepatic Cirrhosis><Hepatic Disorder><High Throughput Assay><Homeostasis><Human><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><In Vitro><In vivo analysis><Incubated><Individual><Induction of Apoptosis><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intermediary Metabolism><Intestinal><Intestinal Absorption><Intestinal Content><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Intracellular Communication and Signaling><Libraries><Link><Liver><Liver Cirrhosis><Liver Steatosis><Liver diseases><MAP Kinase Gene><MAP kinase><MAPK><Macrophage><Massachusetts><Measures><Mediating><Metabolic Processes><Metabolic syndrome><Metabolism><Metagenomics><Mice><Mice Mammals><Microbiomics><Mitochondria><Mitogen-Activated Protein Kinase Gene><Mitogen-Activated Protein Kinases><Modern Man><Morphology><Murine><Mus><Mφ><NASH><Nutrient><Obesity><Occluding Junctions><Pathogenesis><Pathway interactions><Patients><Phase><Phase Transition><Phenotype><Physiological Homeostasis><Pilot Projects><Policies><Portal Vein><Portal vein structure><Production><Prognosis><Proteins><Pteroylglutamic Acid><Public Health><RNA Expression><Rat><Rats Mammals><Rattus><Reactive Site><Receptor Activation><Receptor Signaling><Research><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><Sampling><Severities><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Targeted Research><Techniques><Testing><Therapeutic><Tight Junctions><Tissue Growth><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Upregulation><Vitamin M><Work><Zonula Occludens><absorption><adiposity><bacteria in the gut><bariatric surgery><bile salts><biological signal transduction><bowel><bowel inflammation><choline deficient diet><cirrhotic><co-morbid><co-morbidity><cohort><comorbidity><corpulence><developmental><dietary><disease prognosis><disease prognostication><driving><fecal sample><folate carrier><folate receptor><folate-binding protein><folate-methotrexate transporter><folic acid binding protein><folic acid receptor><gastric banding><gastric bypass surgery><gastrointestinal absorption><gastrointestinal epithelium><gastrointestinal homeostasis><gut bacteria><gut inflammation><hepatic body system><hepatic disease><hepatic organ system><hepatic steatosis><hepatopathy><hepatosteatosis><high throughput screening><ileum><implantable gastric stimulation banding><in vivo evaluation><in vivo testing><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><inflammatory modulation><inhibitor><intestinal autoinflammation><intestinal epithelium><intestinal homeostasis><intestinal inflammation><liver disorder><medical college><medical schools><metabolic engineering><metabolism measurement><metabolomics><metabonomics><methotrexate-binding protein><microbial><microbiome><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><mitochondrial><non-alcohol induced steatohepatitis><non-alcoholic steato-hepatitis><non-alcoholic steatohepatitis><nonalcoholic steato-hepatitis><nonalcoholic steatohepatitis><novel><obesity surgery><ontogeny><pathway><pilot study><prevent><preventing><school of medicine><screening><screenings><small molecule><social role><stomach stapling><stool><stool sample><stool specimen><therapeutic agent development><therapeutic development><transcription factor><vitamin Bc><weight loss surgery>
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JUSTIN L SONNENBURG

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 16/100
Active award
$215,985
FY 2026

Project Title

Modulating Human Microbiome Function to Enhance Immune Responses Against Cancer

Grant Number:

5R21CA290426-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY Cancer immunotherapy has been one of the great recent breakthroughs in cancer treatment options. Antibodies that antagonize immune-inhibitory receptors, a therapy type known as immune checkpoint blockade (ICB), show great promise and further improvements in response rates and durabil...

Research Terms

<Address><After Care><After-Treatment><Aftercare><Aggregated Data><Alimentary Canal><Amaze><Animal Cancer Model><Animal Model><Animal Models and Related Studies><Antibodies><Bacteria><Biological><Biological Response Modifiers><Biology><Biomodulators><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cancer Model><Cancer Patient><Cancer Treatment><CancerModel><Cancers><Candidate Disease Gene><Candidate Gene><Causality><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Clinical Data><Complex><DNA Molecular Biology><Data><Data Aggregation><Data Analyses><Data Analysis><Data Set><Digestive Tract><Dimensions><Disease remission><Distal><Etiology><Failure><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional Metagenomics><Future><GI Tract><GI microbiome><GI microbiota><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Gene Modified><General Taxonomy><Generations><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Germ-Free><Gnotobiotic><Gnotobiotics><Goals><Human><Human Microbiome><Immune><Immune Mediators><Immune Mediators/Modulators><Immune mediated therapy><Immune response><Immune system><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologically Directed Therapy><Immunologics><Immunotherapy><In complete remission><Individual><Individuality><Knowledge><Link><Lymphoid><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mediating><Mediator><Melanoma Metastasis><Melanoma patient><Metagenomics><Metastatic Melanoma><Mice><Mice Mammals><Microbe><Microbiomics><Modern Man><Molecular><Molecular Biology><Molecular Genetics><Murine><Mus><Operon><Outcome><PD-L1 antibody><Patients><Phenotype><Phylogenetic Analysis><Phylogenetics><Play><Process><Receptor Protein><Recombinant DNA Technology><Remission><Research><Resistance><Role><Sample Size><Sampling><Site><Source><Subcellular Process><Survival Rate><System><T8 Cells><T8 Lymphocytes><Taxonomy><Techniques><Testing><Transplantation><Tumor Immunity><aPD-L1><aPD-L1 antibodies><alimentary tract><analysis pipeline><anti programmed cell death ligand 1><anti programmed cell death protein ligand 1><anti-PD-(L)1><anti-PD-L1><anti-PD-L1 antibodies><anti-PD-L1 monoclonal antibodies><anti-PDL-1><anti-PDL1><anti-PDL1 antibodies><anti-cancer immunotherapy><anti-cancer therapy><anti-tumor immune response><anti-tumor immunity><antiPD-L1><anticancer immunotherapy><antitumor immunity><biologic><cancer immunity><cancer immunotherapy><cancer microenvironment><cancer therapy><cancer type><cancer-directed therapy><candidate identification><causation><check point blockade><checkpoint blockade><clinical relevance><clinically relevant><cohort><commensal flora><commensal microbes><commensal microbiota><commensal microflora><community microbes><complete response><data analysis pipeline><data interpretation><data modeling><data processing pipeline><develop therapy><digestive canal><digestive tract microbiome><disease causation><enteric microbial community><enteric microbiome><enteric microbiota><experiment><experimental research><experimental study><experiments><flow cytophotometry><gastrointestinal microbial flora><gastrointestinal microbiome><gene modification><genetically engineered><genetically modified><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host response><human-associated microbiome><immune check point blockade><immune checkpoint blockade><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapies><immune-based treatments><immuno therapy><immunological status><immunoresponse><immunotherapy for cancer><immunotherapy of cancer><improved><individualized therapeutic><insight><interest><intervention development><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><malignancy><melanoma cancer model><melanoma model><melanoma tumor model><metabolism measurement><metabolomics><metabonomics><metagenome><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbiome><microbiome community composition><microbiome composition><microbiome intervention><microbiome research><microbiome science><microbiome species composition><microbiome structure><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><microbiota><microflora><microorganism community><model of animal><model of data><model the data><modeling of the data><mouse model><multispecies consortia><murine model><neoplasm/cancer><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><patients suffering from melanoma><patients with melanoma><personalized therapeutic><polymicrobial community><post treatment><receptor><resistant><responders and non-responders><responders from non-responders><responders or non-responders><responders versus non-responders><responders vs non-responders><responders/nonresponders><response><response to therapy><response to treatment><social role><subcutaneous melanoma><success><therapeutic response><therapy development><therapy response><tool><transplant><treatment development><treatment response><treatment responsiveness><treatment strategy><tumor><tumor microenvironment><αPD-L1><αPD-L1 antibodies><αPDL1>
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Peter Belenky

BROWN UNIVERSITY, PROVIDENCE, RI

Exploratory lead · 16/100
Active award
$199,375
FY 2026

Project Title

Alleviating antibiotic-induced gut dysbiosis by restoring small intestinal bile acid metabolism

Grant Number:

5R21AI183146-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/8/2024

End Date:

10/31/2026

Project Abstract

PROJECT SUMMARY Antibiotic-induced damage to the natural flora of the human GI is associated with significant morbidity. As we advance more efficient strategies to fight the current antimicrobial resistance crisis, we must also develop therapeutic methodologies to reduce the collateral damage to th...

Research Terms

<Alimentary Canal><Amoxicillin><Amoxicilline><Amoxil><Amoxycillin><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotic susceptibility><Antibiotics><Antimicrobial Resistance><Attention><Bacteria><Bile Acids><Communities><Complex><Data><Data Set><Development><Dietary Supplementation><Digestive Tract><Distal><Drugs><Enzyme Gene><Enzymes><Face><Foundations><GI Tract><GI microbiome><GI microbiota><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Generalized Growth><Generations><Goals><Growth><Health><Hydrolase><Hydrolase Family Gene><Hydrolase Gene><Hydroxyampicillin><Immunity><Infection><Inflammation><Inflammatory><Intermediary Metabolism><Intervention><Intervention Strategies><Intestinal><Intestines><Invaded><Large Intestine><Length><Life><Link><Lipids><Location><Lower GI Tract><Lower Gastrointestinal Tract><Medication><Metabolic Processes><Metabolism><Methodology><Mice><Mice Mammals><Microbe><Miscellaneous Antibiotic><Morbidity><Multiomic Data><Murine><Mus><Nutrient availability><Obesity><Oral><Pathogenicity><Pharmaceutical Preparations><Polymox><Predisposition><Probiotics><Process><Property><Publishing><Research><Role><Shapes><Signaling Molecule><Small Intestines><Susceptibility><Testing><Therapeutic><Tissue Growth><Trimox><Upper GI><Upper GI Tract><Upper Gastrointestinal Tract><Upper digestive tract structure><Utimox><Work><Wymox><absorption><adiposity><alimentary tract><anti-microbial><anti-microbial resistant><antimicrobial><bacterial disease treatment><bacterial infectious disease treatment><bile acid metabolism><bile metabolism><bile salts><bowel><community microbes><corpulence><determine efficacy><developmental><diet supplement><diet supplementation><dietary supplements><digestive canal><digestive tract microbiome><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><enteric microbial community><enteric microbiome><enteric microbiota><entire genome><evaluate efficacy><examine efficacy><faces><facial><fighting><full genome><gastrointestinal microbial flora><gastrointestinal microbiome><genome sequencing><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbe association><host microbe relationship><host-microbe interactions><host-microbial interactions><host-microorganism interactions><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiota><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><large bowel><metabolism measurement><metabolomics><metabonomics><microbe community><microbial><microbial community><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microbiota composition><microflora><microorganism community><mortality><mouse model><multiple omic data><multispecies consortia><murine model><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><nutritional supplement><ontogeny><pathobiont><pathogen><pharmacologic><polymicrobial community><prebiotics><prevent><preventing><resistance to anti-microbial><resistant to antimicrobial><restoration><small bowel><social role><whole genome>
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Minsoo Kim

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Exploratory lead · 16/100
Active award
$192,500
FY 2026

Project Title

Microbiomes regulate neutrophil responses in sepsis

Grant Number:

5R21AI184402-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/3/2025

End Date:

1/31/2027

Project Abstract

Microbiomes regulate neutrophil responses in sepsis. Sepsis is defined as a systemic inflammatory response to infection that causes vital organ dysfunction. Although sepsis is one of the most common causes of hospital death, patient responses to this disease are highly heterogeneous, making it diffi...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Acute><Address><Adoptive Transfer><Antibiotic Therapy><Antibiotic Treatment><Autoregulation><Bacterial DNA><Blood><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood Reticuloendothelial System><Body System><Body Tissues><Brain><Brain Nervous System><COVID-19 virus><COVID19 virus><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cessation of life><Chronic><CoV-2><CoV2><Death><Disease><Disease Outbreaks><Disorder><Dysfunction><Encephalon><Exposure to><Failure><Functional disorder><Gene Transcription><Genetic Transcription><Goals><Homeostasis><Hospitals><Human><Hyperactivity><Immune><Immune response><Immune system><Immunes><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><In Vitro><Individual><Infection><Inflammation><Inflammatory><Inflammatory Response><Innate Immune Response><Intracellular Communication and Signaling><Kidney><Kidney Urinary System><Knowledge><Laboratories><Link><Liver><Lung><Lung Respiratory System><Marrow Neutrophil><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Molecular Target><Morbidity><Murine><Mus><Neutrophil Infiltration><Neutrophil Recruitment><Neutrophilic Granulocyte><Neutrophilic Infiltrate><Neutrophilic Leukocyte><Organ><Organ System><Outbreaks><Patients><Phenocopy><Phenotype><Physiological Homeostasis><Physiopathology><Play><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Prevention><Process><Property><RNA Expression><Recovery><Resolution><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sepsis><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Signal Transduction><Signal Transduction Systems><Signaling><Site><Spleen><Spleen Reticuloendothelial System><Supportive Therapy><Supportive care><Testing><Therapeutic><Tissues><Training><Transcription><Viral Diseases><Viral Respiratory Tract Infection><Virus Diseases><Wuhan coronavirus><arm><bacterial disease treatment><bacterial infectious disease treatment><biological signal transduction><coronavirus disease 2019 virus><coronavirus disease-19 virus><death due to sepsis><death related to sepsis><disease diagnosis><disease prognosis><disease prognostication><experience><functional adaptation><germ free condition><hCoV19><hepatic body system><hepatic organ system><host response><human flora><human microbial communities><human microbiota><human microflora><human-associated microbial communities><human-associated microbiota><immune system response><immunoresponse><improved><microbial consortia><microbial flora><microbiome><microbiota><microflora><migration><mortality><mortality associated with sepsis><mortality in sepsis><mouse model><multispecies consortia><murine model><nCoV2><neutrophil><pathogen><pathophysiology><patient response><patient specific response><renal><resolutions><response><responsive patient><sepsis associated death><sepsis associated mortality><sepsis caused deaths><sepsis death><sepsis induced death><sepsis induced mortality><sepsis lethality><sepsis mortality><sepsis related deaths><sepsis related mortality><sepsis survivor><sepsis survivorship><septic death><septic mortality><septic survival><septic survivor><social role><specific pathogen free><survive sepsis><systemic inflammation><systemic inflammatory response><viral infection><viral respiratory infection><virus infection><virus-induced disease>
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Justin Ray Kaspar

OHIO STATE UNIVERSITY, Columbus, OH

Exploratory lead · 16/100
Active award
$163,561
FY 2026

Project Title

Nutritional Niches within Supragingival Biofilms

Grant Number:

5R03DE034484-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2025

End Date:

2/28/2027

Project Abstract

PROJECT SUMMARY / ABSTRACT The bacteria that colonize the oral cavity, forming biofilms on surfaces such as the hard tissues of teeth, participate in complex exchanges with other microbes inhabiting the same niche. One such example is the relationship between Streptococcus mutans, one of the primary...

Research Terms

<21+ years old><Acids><Address><Adolescent><Adolescent Youth><Adult><Adult Dentition><Adult Human><Assay><Bacteria><Bioassay><Biological Assay><Bionomics><Buccal Cavity><Buccal Cavity Head and Neck><Carbohydrates><Carbon><Caries><Caries prevention><Cavitas Oris><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Chemistry><Clinical><Co-culture><Cocultivation><Coculture><Coculture Techniques><Communities><Complex><Confocal Microscopy><Coupled><Data><Data Set><Dental Decay><Dental Enamel><Dental caries><Development><Dietary Carbohydrates><Disease><Disorder><Ecology><Enamel><Engineering><Equilibrium><Fermentation><Foundations><Future><Gene Expression><Generalized Growth><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Goals><Growth><Habitats><Health><Human><In Vitro><Individual><Intervention Strategies><Kinases><Knowledge><Label><Lead><Measures><Metabolic><Methods><Microbe><Microbial Biofilms><Modeling><Modern Man><Mouth><Mouth microbiome><Nutritional><Oral><Oral cavity><Oral health><Outcome><Pathway interactions><Pattern><Pb element><Permanent Dentition><Phosphotransferase Gene><Phosphotransferases><Probiotics><Process><Production><Recombinant DNA Technology><Research><Role><S mutans><S. mutans><Saliva><Sampling><Secondary Dentition><Site><Source><Streptococcus><Streptococcus mutans><Structure><Surface><System><Testing><Therapeutic Intervention><Tissue Growth><Tooth Demineralization><Tooth Hypomineralization><Tooth Tissue><Transphosphorylases><Visualization><adulthood><balance><balance function><biofilm><biofilm community><cariogenic bacteria><cell sorting><commensal bacteria><commensal bacterial species><commensal community><commensal microbiome><commensal species><community microbes><demineralization><dental caries prevention><dental health><developmental><dysbacteriosis><dysbiosis><dysbiotic><fitness><genetically engineered><global gene expression><global transcription profile><heavy metal Pb><heavy metal lead><in silico><indexing><intervention therapy><juvenile><juvenile human><member><metagenome sequencing><metagenomic sequencing><microbe community><microbial><microbial community><microbial imbalance><microbial interaction><microbiome community><microorganism community><microorganism interaction><microscope imaging><microscopic imaging><microscopy imaging><mixed species biofilm><multi-microorganism biofilm><multispecies biofilm><mutant><network models><nutritious><ontogeny><oral bacteria><oral biofilm><oral commensal><oral flora><oral microbiome><oral streptococci><organic acid><pathway><permanent tooth><polymicrobial biofilm><polymicrobial community><prebiotics><preference><prevent><preventing><resident commensals><single cell analysis><social role><super high resolution><superresolution><superresolution microscopy><tooth decay><tooth enamel><tooth surface><transcriptome><transcriptomics><ultra high resolution><uptake>
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NASIA SAFDAR

WM S. MIDDLETON MEMORIAL VETERANS HOSP, MADISON, WI

Exploratory lead · 16/100
Active award
$0
FY 2026

Project Title

BCCMA: Targeting Gut-Microbiome in Veterans Deployment related Gastrointestinal and Liver diseases; CMA5- Functional metagenomics in GWI-related gut dysfunction

Grant Number:

5I01CX002471-03

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

7/1/2023

End Date:

6/30/2028

Project Abstract

Gulf War Illness (GWI) is estimated to affect 25-32% of the over 700,000 coalition troops deployed to the Persian Gulf as part of the First Gulf War. GWI causes a wide array of pain, fatigue, gastrointestinal, skin, neurologic, and respiratory symptoms. Longitudinal studies have shown little to no o...

Research Terms

<Address><Affect><Age><Appetite><Award><Bile Acids><Biological Markers><Blood Serum><Butyrates><Chronic><Chronic stress><Clinical Trials><Collaborations><Consumption><Cramp><Critical Illness><Critically Ill><Data><Desire for food><Development><Diarrhea><Diet><Dietary Fiber><Dietary fiber fermentation><Disease><Disorder><Dysfunction><Emesis><Enrollment><Fatigue><Feces><Fermentation><Fiber><Firmicutes><Functional Metagenomics><Functional disorder><Funding><GI microbiome><GI microbiota><GW veteran><Gastrointestinal Diseases><Gastrointestinal microbiota><Genes><Goals><Gulf War><Gulf War Illness><Gulf War Syndrome><Gulf War veteran><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><Health><Hepatic Disorder><Human><Immunity><Incidence><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intermediary Metabolism><Intervention><Intervention Studies><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Irritable Bowel Syndrome><Irritable Colon><Knowledge><Lack of Energy><Liver diseases><Long-term cohort><Longitudinal Studies><Longitudinal Surveys><Longitudinal cohort><Measures><Mediating><Metabolic Processes><Metabolism><Metagenomics><Mice><Mice Mammals><Modality><Modeling><Modern Man><Morbidity><Mucous Colitis><Murine><Mus><Muscle Cramp><Muscular Cramp><Nausea><Neurologic Manifestations><Neurologic Signs and Symptoms><Neurologic Symptoms><Neurological Manifestations><Neurological Signs and Symptoms><Non-digestible Fibers><Operation Desert Shield><Operation Desert Storm><Outcome><PTSD><Pain><Painful><Patients><Persian Gulf><Persian Gulf Syndrome><Physiopathology><Play><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Potato><Predisposition><Production><QOL><QOL improvement><Quality of life><Questionnaires><RNA Seq><RNA sequencing><RNAseq><Randomized><Reporting><Research><Resistance><Respiratory Signs and Symptoms><Risk><Role><Serum><Short-Chain Fatty Acids><Skin><Source><Starch><Structure><Supplementation><Susceptibility><Symptoms><Technology><Therapeutic><Time><Veterans><Volatile Fatty Acids><Vomiting><Work><ages><aging process><airway symptom><alleviate symptom><ameliorating symptom><assess effectiveness><associated symptom><bio-markers><biologic marker><biomarker><bowel inflammation><co-morbid><co-morbid symptom><co-morbidity><co-occuring symptom><cohort><combat><comorbid symptom><comorbidity><compare to control><comparison control><concurrent symptom><cooccuring symptom><cost><cytokine><decrease symptom><determine effectiveness><developmental><diarrheal disease><diarrheal illness><dietary fiber digestion><diets><digestive tract microbiome><effectiveness assessment><effectiveness evaluation><enroll><enteric microbial community><enteric microbiome><enteric microbiota><evaluate effectiveness><examine effectiveness><experience><fecal sample><fewer symptoms><gastrointestinal><gastrointestinal disorder><gastrointestinal microbial flora><gastrointestinal microbiome><gastrointestinal symptom><gut community><gut flora><gut homeostasis><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><hepatic disease><hepatopathy><humanized mice><humanized mouse><improved><improvements in QOL><improvements in quality of life><in vivo Model><indexing><inflamed bowel><inflamed gut><inflamed intestine><inflammation marker><inflammatory disease of the intestine><inflammatory disorder of the intestine><inflammatory marker><insight><intervention research><interventional research><interventional study><interventions research><intestinal autoinflammation><intestinal biome><intestinal flora><intestinal inflammation><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><knowledge base><liver disorder><long-term study><longitudinal outcome studies><longitudinal research study><metagenome sequencing><metagenomic sequencing><microbial consortia><microbial flora><microbiome><microbiota><microflora><mouse model><multispecies consortia><murine model><neural manifestation><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathophysiology><post-trauma stress disorder><posttrauma stress disorder><prebiotic fibers><prebiotics><quality of life improvement><randomisation><randomization><randomly assigned><reduce symptoms><relieves symptoms><resistant><respiratory symptom><social role><spastic colon><stool><stool sample><stool specimen><symptom alleviation><symptom association><symptom comorbidity><symptom reduction><symptom relief><transcriptome sequencing><transcriptomic sequencing><translational impact><traumatic neurosis>
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Jeffrey R Capadona

LOUIS STOKES CLEVELAND VA MEDICAL CENTER, CLEVELAND, OH

Exploratory lead · 16/100
Active award
$0
FY 2026

Project Title

Senior Research Career Scientist

Grant Number:

5IK6RX003077-08

Activity Code:

IK6

Mechanism:

Other

Agency:

VA

Start Date:

1/1/2019

End Date:

12/31/2030

Project Abstract

Overall goals: My laboratory strives to understand and facilitate the neuroinflammatory response to all implanted devices within the central nervous system. Such devices range from ventricular shunts to various types of stimulating and recording electrodes. However, most of my efforts have been on i...

Research Terms

<Activities of Daily Living><Activities of everyday life><Affect><American><Amputees><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Animal Model><Animal Models and Related Studies><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antioxidants><Apoplexy><Area><Armed Forces Personnel><Artificial Extremities><Artificial Limbs><Assistive Technology><Attenuated><BBB crossing><Basic Research><Basic Science><Bathing><Baths><Behavior><Belief><Biocompatible Materials><Biological><Biomaterials><Blood Circulation><Bloodstream><Body Tissues><Brain><Brain Nervous System><Brain Vascular Accident><CNS Nervous System><Care Givers><Caregivers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular immunotherapy><Central Nervous System><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cervical><Cervical Injury><Cervical spinal cord injury><Chemistry><Chronic><Clinical><Clinical Treatment><Computers><Corrosives><DNA Therapy><Dedications><Deep Brain Stimulation><Devices><Disabling><Disease><Disorder><Drugs><Electrodes><Encephalon><Engineering><Enzyme Gene><Enzymes><Failure><Feces><GI microbiome><Gehrig's Disease><Gene Transfer Clinical><Genes><Genetic Intervention><Geometry><Goals><Government><Health Care><Immunity><Implant><Individual><Infiltration><Inflammatory><Inflammatory Infiltrate><Inflammatory Response><Injury><Innate Immune System><Innate Immunity><Institution><Intracellular Communication and Signaling><Investigation><Investigators><Journals><Laboratories><Length of Life><Life Expectancy><Limb Prosthesis><Liquid substance><Literature><Longevity><Lou Gehrig Disease><Lower Extremity><Lower Limb><Magazine><Manuscripts><Mechanics><Mediating><Medical Rehabilitation><Medication><Membrum inferius><Membrum superius><Methods><Microelectrodes><Military><Military Personnel><Miniaturized Electrodes><Mission><Modeling><Modulus><Molecular><Motion><Movement><Muscle><Muscle Tissue><Names><Nanotechnology><Native Immunity><Natural Immunity><Nature><Nerve Cells><Nerve Degeneration><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neuraxis><Neurocyte><Neurologic Disorders><Neurological Disorders><Neuron Degeneration><Neuronal Transmission><Neurons><Neurosciences><Non-Specific Immunity><Nonspecific Immunity><Outcome><Oxidative Stress><Palsy><Paralysed><Pathologic><Pathway interactions><Patients><Peer Review><Performance><Persons><Pharmaceutical Preparations><Plegia><Polymers><Preclinical data><Privatization><Process><Proteins><Publishing><QOL><Quadriplegia><Quadriplegic><Quality of life><Recovery><Rehabilitation><Rehabilitation therapy><Reporting><Research><Research Personnel><Researchers><Resolution><Ribosomal RNA><Robotics><Role><SCI Patients><Science><Scientist><Self-Help Devices><Seminal><Services><Shunt><Shunt Device><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Spinal Cord Trauma><Spinal Trauma><Spinal cord injured><Spinal cord injury><Spinal cord injury patients><Sterility><Stroke><System><Technology><Tetraplegia><Therapeutic><Thinking><Time><Tissues><Translating><Traumatic Myelopathy><Upper Extremity><Upper Limb><Ventricular><Veterans><Work><arm><assisted device><assistive device><attenuate><attenuates><axon signaling><axon-glial signaling><axonal signaling><biologic><biological material><biological signal transduction><biomacromolecular><biomacromolecule><biomedical implant><blood-brain barrier crossing><bloodbrain barrier crossing><body movement><brain attack><brain computer interface><brain health><brain machine interface><brain tissue><career><cell-based immunotherapy><cerebral vascular accident><cerebrovascular accident><clinical applicability><clinical application><clinical intervention><clinical therapy><communication device><daily living function><daily living functionality><digestive tract microbiome><disability><disabled><drug/agent><enteric microbiome><epilepsy monitoring><epilepsy recording><epilepsy tracking><epileptic monitoring><epileptic recording><epileptiform monitoring><epileptiform recording><epileptiform tracking><epileptogenic monitoring><experience><falls><feeding><fluid><functional ability><functional capacity><gastrointestinal microbiome><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><glia signaling><glial signaling><gut microbiome><gut-associated microbiome><immune cell therapy><implant device><implantable device><implantation><improved><indexing><indwelling device><injured><injuries><interest><intestinal biome><intestinal microbiome><limb loss><liquid><lost limb><materials science><mechanic><mechanical><mechanical device><metallicity><microbiome><military population><mimetics><model of animal><multidisciplinary><muscular><name><named><naming><nano tech><nano technology><nano-technological><nanotech><nanotechnological><nerve signaling><neural><neural degeneration><neural inflammation><neural signaling><neurodegeneration><neurodegenerative><neuroinflammation><neuroinflammatory><neurological degeneration><neurological disease><neuronal><neuronal degeneration><neuronal signaling><neuroprotection><neuroprotective><neurotransmission><paralysis><paralytic><pathway><polymer><polymeric><preclinical findings><preclinical information><prosthetic limb><rRNA><rehab therapy><rehabilitative><rehabilitative therapy><resolutions><response><seizure detection><seizure monitoring><seizure recording><seizure tracking><shunts><social role><spatial and temporal><spatial temporal><spatiotemporal><sterile><stool><stroked><strokes><tetraplegic><thoughts><trial regimen><trial treatment>
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Seema Saksena

JESSE BROWN VA MEDICAL CENTER, CHICAGO, IL

Exploratory lead · 16/100
Active award
$0
FY 2026

Project Title

Mechanisms Underlying Role of Intestinal P-glycoprotein in Inflammatory Bowel Disease

Grant Number:

5I01BX002867-10

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2015

End Date:

12/31/2028

Project Abstract

Project Summary/Abstract Background and Innovation: P-glycoprotein (Pgp/MDR1), encoded by the ABCB1 gene protects intestinal epithelium by mediating the efflux of xenobiotics and bacterial toxins from the mucosa into the lumen. Polymorphisms in the human MDR1 gene have been associated with ulcerativ...

Research Terms

<ABC20><ABCB1><ABCB1 gene><Adrenal Cortex Hormones><Age><Animal Model><Animal Models and Related Studies><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Bacteria><Bacterial Toxins><Bacteroides><Biological Agent><Biological Products><C rodentium><C. rodentium><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Chromosome 7><Chronic><Citrobacter freundii Biotype 4280><Citrobacter rodentium><Colitis><Colon><Corticoids><Corticosteroids><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><Data><Defect><Development><Down-Regulation><Dysfunction><Elderly><Energy-Generating Resources><Epithelium><Event><Exhibits><Fc Receptor><Financial Hardship><Functional disorder><GI microbiome><GP170><Genes><Genetic Polymorphism><Germ-Free><Granulomatous Enteritis><Health><Health Care><Health Care Costs><Health Costs><Host Defense><Human><IL-10 receptor><Impairment><Incidence><Infection><Infection prevention><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal><Intestines><Invaded><KO mice><Knock-out Mice><Knockout Mice><Link><Lysozyme><MDR-1><MDR1><MDR1 Protein><Mediating><Mice><Mice Mammals><Mission><Modern Man><Molecular><Morbidity><Mucosa><Mucosal Inflammation><Mucosal Tissue><Mucositis><Mucous Membrane><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><Muramidase><Murine><Mus><N-Acetylmuramide Glycanhydrolase><Null Mouse><Occluding Junctions><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PGY-1 Protein><PGY1><Paneth Cells><Pathogenesis><Patients><Peptidoglycan N-acetylmuramoylhydrolase><Permeability><Physiopathology><Play><Predisposition><Predisposition gene><Prevent infection><Prevention><Proteins><Pump><Research Priority><Role><S sanguinis><S sanguis><S. sanguinis><S. sanguis><Short-Chain Fatty Acids><Spontaneous colitis><Staining method><Stains><Streptococcus sanguinis><Streptococcus sanguis><Subcellular Process><Susceptibility><Susceptibility Gene><Testing><Therapeutic Intervention><Tight Junctions><Time><Translations><Treatment outcome><Ulcerated Colitis><Ulcerative Colitis><Veterans><Volatile Fatty Acids><Xenobiotics><Zonula Occludens><advanced age><ages><angiogenin><anti-microbial><anti-microbial peptide><antibody receptor><antimicrobial><biologics><biopharmaceutical><biotherapeutic agent><bowel><bowel inflammation><design><designing><developmental><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><economic hardship><economic strain><eleocolitis><energy source><enteral infection><enteral pathogen><enteric infection><enteric microbiome><enteric pathogen><enteric pathogen infection><enteropathogen><enteropathogen infection><enteropathogenic infection><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><gastrointestinal homeostasis><gastrointestinal microbiome><geriatric><gut dysbiosis><gut inflammation><gut microbiome><gut-associated microbiome><healing><ileum><infected with enteropathogen><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><interleukin-10 receptor><intervention therapy><intestinal autoinflammation><intestinal biome><intestinal epithelium><intestinal homeostasis><intestinal infection><intestinal inflammation><intestinal microbiome><intestinal pathogen><intestine infection><intestine pathogen><microbial><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><microbiota><microflora><model of animal><mouse model><multispecies consortia><murine model><novel><oral supplement><oral supplementation><pathophysiology><polymorphism><pre-clinical><preclinical><predisposing gene><prevent><preventing><regional enteritis><response><restoration><senior citizen><social role><success><susceptibility allele><susceptibility locus><susceptibility variant><therapeutically effective><translation>
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Pradeep K Dudeja

JESSE BROWN VA MEDICAL CENTER, CHICAGO, IL

Exploratory lead · 10/100
Active award
$0
FY 2026

Project Title

BCCMA: Targeting Gut-Microbiome in Veterans Deployment Related Gastrointestinal and Liver Diseases; CMA1- The Role of GWI Gut Microbiome in Susceptibility to Diarrheal Diseases

Grant Number:

5I01BX005862-04

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2022

End Date:

9/30/2026

Project Abstract

This revised BLRD and CSRD Collaborative Merit Award (BCCMA) application is being submitted as part of a group of 5-linked CMAs from nationwide VA investigators in gastrointestinal (GI) and liver diseases, who formed a national steering committee after participating in a successful field-based meeti...

Research Terms

<Address><Animal Model><Animal Models and Related Studies><Apical><Award><Bicarbonates><Biological Response Modifier Therapy><Biological Therapy><Butyrates><C diff><C difficile><C rodentium><C. diff><C. difficile><C. rodentium><Cadherin-1><Chemicals><Chlorides><Chronic stress><Citrobacter freundii Biotype 4280><Citrobacter rodentium><Clostridioides difficile><Clostridium difficile><Collaborations><Colon><Data><Development><Diarrhea><Disease><Disorder><Down-Regulated in Adenoma><DownRegulated in Adenoma><Dysfunction><E-Cadherin><EPEC><Electrolytes><Epithelial Calcium-Dependent Adhesion Protein><Epithelial-Cadherin><Event><Exhibits><Exposure to><Fluids and Secretions><Functional Metagenomics><Functional disorder><Funding><GI microbiome><Gastroenterology><Gastrointestinal Diseases><Gulf War><Gulf War Illness><Gulf War Syndrome><HCO3><Hepatic Disorder><Human><Hydrogen Carbonates><Incidence><Infection><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal><Intestinal Absorption><Intestines><Investigators><Ions><Journals><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Link><Liver diseases><Magazine><Metagenomics><Mice><Mice Mammals><Microbe><Modality><Modeling><Modern Man><Morbidity><Murine><Mus><NHE-3 protein><Neutrophil Infiltration><Neutrophil Recruitment><Neutrophilic Infiltrate><Null Mouse><Operation Desert Shield><Operation Desert Storm><Outcome><PTSD><Pathogenesis><Persian Gulf Syndrome><Phenotype><Physiopathology><Play><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Predisposition><Probiotics><Proteins><Publishing><RNA Seq><RNA sequencing><RNAseq><Research><Research Personnel><Researchers><Risk><Role><SLC26A3><SLC26A3 gene><Source><Structure><Susceptibility><Symptoms><Technology><Therapeutic><Time><Transgenic Mice><Uvomorulin><Veterans><War><absorption><alter microbiome><beneficial flora><beneficial microbes><beneficial microflora><beneficial microorganism><biological therapeutic><biological treatment><biologically based therapeutics><biotherapeutics><biotherapy><bowel><bowel inflammation><determine efficacy><developmental><diarrheal disease><diarrheal illness><digestive tract microbiome><dysbacteriosis><dysbiosis><dysbiotic><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><enteric microbiome><enteropathogenic E coli><enteropathogenic E. coli><enteropathogenic E.coli><enteropathogenic Escherichia coli><evaluate efficacy><examine efficacy><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal absorption><gastrointestinal disorder><gastrointestinal microbiome><gut dysbiosis><gut inflammation><gut microbiome><gut-associated microbiome><health care burden><hepatic disease><hepatopathy><human subject><humanized mice><humanized mouse><imaging system><in vivo Model><in vivo optical imaging><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><intestinal autoinflammation><intestinal barrier><intestinal biome><intestinal inflammation><intestinal microbiome><intestinal mucosal barrier><liver disorder><meeting><meetings><microbial><microbial imbalance><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><model of animal><mouse model><murine model><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><occludin><overexpress><overexpression><pathogen><pathophysiology><post-trauma stress disorder><posttrauma stress disorder><social role><sodium-hydrogen exchanger 3><transcriptome sequencing><transcriptomic sequencing><translational impact><traumatic neurosis><treatment strategy>
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Ashutosh Kumar Mangalam

IOWA CITY VA MEDICAL CENTER, IOWA CITY, IA

Exploratory lead · 10/100
Active award
$0
FY 2026

Project Title

Role of HLA Class-II Polymorphism in the Regulation of Host-Microbiota Symbiosis

Grant Number:

5I01BX006112-03

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2023

End Date:

9/30/2027

Project Abstract

Both HLA class-II polymorphism and gut microbiota had been linked with the regulation of host immunity and pathobiology of multiple sclerosis (MS) However, it is not known whether there is a crosstalk between HLA class-II molecules and gut microbiota in the regulation of host immunity which can infl...

Research Terms

<0-4 weeks old><21+ years old><Adult><Adult Human><Affect><Alleles><Allelomorphs><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Autoimmune Diseases><Autoregulation><Bacteria><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CNS Diseases><CNS disorder><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Central Nervous System Diseases><Central Nervous System Disorders><Class II Genes><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Data><Dependence><Development><Diagnostic><Diathesis><Disease><Disease Outcome><Disease Resistance><Disease susceptibility><Disorder><Disseminated Sclerosis><EAE><Environmental Factor><Environmental Risk Factor><Experimental Allergic Encephalitis><Experimental Allergic Encephalomyelitis><Experimental Autoimmune Encephalitis><Experimental Autoimmune Encephalomyelitis><Fostering><Frequencies><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genes><Genetic><Genetic Polymorphism><Germ-Free><Goals><HLA Class II Genes><HLA-BR><HLA-BR Antigens><HLA-D-Related Antigens><HLA-DQ8><HLA-DQ8 antigen><HLA-DR><HLA-DR Antigens><HLA-DR3><HLA-DR3 Antigen><HLA-MT><HLA-MT Antigens><Homeostasis><Human><Human Figure><Human body><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immunes><Immunity><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunomodulation><Inflammatory><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Lactation><Life><Link><MHC Class II><MHC Class II Genes><MS patient><Mammalia><Mammals><Medical><Mice><Mice Mammals><Microbiomics><Miscellaneous Antibiotic><Modern Man><Multiple Sclerosis><Murine><Mus><Neonatal><Newborn Infant><Newborns><Pathogenesis><Pathogenicity><Pathologic><Persons><Physiological Homeostasis><Play><Predisposition><Reaction><Regulation><Regulatory T-Lymphocyte><Resistance><Role><Severities><Shapes><Subcellular Process><Susceptibility><Symbiosis><T4 Cells><T4 Lymphocytes><Teff cell><Therapeutic Agents><Transgenic Mice><Treg><Veterans><Weaning><adulthood><analyze microbiome><autoimmune condition><autoimmune disorder><autoimmune encephalomyelitis><autoimmunity disease><bacteria in the gut><chronic inflammatory disease><commensalism><cytokine><developmental><digestive tract microbiome><disease phenotype><dysbacteriosis><dysbiosis><dysbiotic><effector T cell><enteric microbial community><enteric microbiome><enteric microbiota><environmental risk><gastrointestinal microbial flora><gastrointestinal microbiome><gut bacteria><gut community><gut dysbiosis><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbiome><host microbiota><host microflora><host response><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><imprint><insular sclerosis><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><lactating><lactational><later in life><later life><liability to disease><microbial consortia><microbial flora><microbial imbalance><microbiome><microbiome analysis><microbiome research><microbiome science><microbiome studies><microbiome transplant><microbiome transplantation><microbiota><microbiota patterns><microbiota profiles><microbiota signature><microbiota transplant><microbiota transplantation><microflora><model of animal><multiple sclerosis patient><multispecies consortia><new diagnostics><newborn child><newborn children><next generation diagnostics><novel><novel diagnostics><pathobiont><patients with MS><patients with multiple sclerosis><people with Multiple sclerosis><polymorphism><prognostic><pup><regulatory T-cells><resident microbes><resident microflora><resistance strain><resistance to disease><resistant><resistant disease><resistant strain><resistant to disease><response><social role><symbiont><therapeutic target><translational opportunities><translational potential>
View Full Project Details on NIH Reporter
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Anoop Kumar

JESSE BROWN VA MEDICAL CENTER, CHICAGO, IL

Exploratory lead · 10/100
Active award
$0
FY 2026

Project Title

A Novel Role of Apical Chloride Transporter (DRA) in Mucosal Tissue Repair

Grant Number:

5I01BX006626-02

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2024

End Date:

9/30/2028

Project Abstract

Inflammatory bowel diseases (IBDs) comprising of Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by chronic inflammation of the GI tract with increasing incidence and prevalence worldwide. Remarkably, over 66,000 US veterans suffer from IBD and exhibit symptoms such as diarrhea, ...

Research Terms

<Abdominal Pain><Acute><Affect><Age><Alimentary Canal><Apical><Beta Cadherin-Associated Protein><Beta-1 Catenin><Bioenergetics><Body Tissues><CUL-2><Cell Communication and Signaling><Cell Cycle><Cell Division Cycle><Cell Lineage><Cell Signaling><Cell-Extracellular Matrix><Chlorides><Chronic><Chronic Disease><Chronic Illness><Colitis><Colon><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><Cytokines and Inflammatory Response><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Data><Diarrhea><Dietary Fats><Digestive Tract><Disease><Disease remission><Disorder><Down-Regulated in Adenoma><Down-Regulation><DownRegulated in Adenoma><ECM><Epithelium><Event><Exhibits><Extracellular Matrix><Ferricytochrome c><Ferrocytochrome c><Flare><GI Tract><GI microbiome><GWA study><GWAS><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Expression><General Population><General Public><Germ-Free><Granulomatous Enteritis><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><HG38><Health Care><Human><Impaired tissue repair><Impaired wound healing><Impairment><Incidence><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Inflammatory Response Pathway><Injury><Intestinal><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Intracellular Communication and Signaling><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><LGR5><LGR5 gene><MOPA><Maintenance><Mice><Mice Mammals><Microscopy><Mission><Mitochondria><Modality><Modeling><Modern Man><Molecular><Morbidity><Morphology><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Natural regeneration><Null Mouse><Outcome Study><Oxidative Stress><PRO2286><Pathogenesis><Pathway interactions><Patients><Permeability><Persons><Play><Population><Predisposition gene><Prevalence><Progenitor Cells><Protein C><RNA Seq><RNA sequencing><RNAseq><Recovery><Regeneration><Relapse><Remission><Research><Resting progenitor><Role><SLC26A3><SLC26A3 gene><Signal Transduction><Signal Transduction Systems><Signaling><Susceptibility Gene><Symptoms><Testing><Therapeutic><Time><Tissues><Transgenic Mice><Ulcerated Colitis><Ulcerative Colitis><United States><Upregulation><Veterans><Wild Type Mouse><Wound Repair><abnormal tissue repair><ages><alimentary tract><beta cat><beta catenin><biological signal transduction><bowel><bowel inflammation><chronic disorder><clinical remission><colitis-induced dysbiosis><cytochrome c><delayed wound healing><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><dietary lipid><digestive canal><digestive tract microbiome><dormant stem cell><dysbacteriosis><dysbiosis><dysbiotic><eleocolitis><enteric microbiome><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbiome><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><gut inflammation><gut microbiome><gut-associated microbiome><healing><health care burden><improved><inactive stem cell><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><injuries><innovate><innovation><innovative><intestinal autoinflammation><intestinal biome><intestinal epithelium><intestinal inflammation><intestinal microbiome><knock-down><knockdown><latent progenitor><latent stem cell><lysophosphatidic acid><microbial><microbial imbalance><mitochondrial><mitochondrial dysfunction><monooleylphosphatidate><monooleylphosphatidic acid><nanostring><novel><overexpress><overexpression><pathway><predisposing gene><prevent><preventing><progenitor cell function><progenitor cell markers><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor function><progenitor markers><progenitor niche><progenitor pool><progenitor population><progenitor stem cell markers><protein expression><quiescent progenitor><quiescent stem cells><regenerate><regional enteritis><repair><repaired><resting stem cell><restoration><social role><stem and progenitor cell function><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor function><stem cell biomarkers><stem cell function><stem cell markers><stem cell niche><stem cell pool><stem cell population><stem cell quiescence><stem cells><susceptibility allele><susceptibility locus><susceptibility variant><therapeutic target><tissue repair><transcriptome sequencing><transcriptomic sequencing><whole genome association analysis><whole genome association study><wildtype mouse><wound healing><wound recovery><wound resolution><β-catenin>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

How to Use PI Funding Data for Career Decisions

Finding the right principal investigator is one of the most important decisions in an academic career. Whether you are a postdoc looking for a mentor, a graduate student choosing a rotation lab, or a collaborator seeking a co-PI, NIH funding data provides objective signals about which investigators have active research programs and resources to support new team members.

A PI with a recently awarded R01 or equivalent grant is more likely to have budget for new personnel than one whose funding ended two years ago. The activity code tells you the type of grant: R01 and R35 awards typically support multiple lab members, while K-series awards are individual career development grants that may not fund additional positions. Understanding these distinctions helps you interpret search results accurately.

Look beyond the dollar amount. A $500,000 per year R01 at a high-cost institution may support fewer positions than a $300,000 award at a university with lower overhead rates. The project abstract and public health relevance statement reveal whether the PI's research direction aligns with your interests and expertise.

Understanding PI Grant Portfolios

A PI's grant portfolio reveals more than individual awards. Investigators with multiple active grants often run larger labs with more diverse projects, which can mean more opportunities for trainees. However, a PI with a single well-funded grant may offer more focused mentorship and a clearer path to publications.

Multi-PI grants (those with more than one principal investigator listed) indicate collaborative research and may involve trainees from multiple institutions. These can be excellent opportunities for interdisciplinary training but may also mean split attention from any single mentor.

Pay attention to the timing of awards. A PI who just received a new five-year R01 is in a different position than one whose grant ends next year. New awards often correspond to lab expansion and active recruiting, making them ideal targets for job seekers. The start and end dates shown in each result help you assess this timing.

Best Practices for Contacting Funded PIs

Once you identify a promising PI through this tool, the next step is outreach. NIH public records do not include email addresses, but you can usually find contact information through the PI's institutional profile page, lab website, or recent publications. Google Scholar, PubMed, and the PI's department website are reliable starting points.

When reaching out, reference the specific grant that caught your attention. Mentioning the project title and explaining how your skills relate to the funded work shows that you have done your homework. Keep your initial message concise: introduce yourself, explain your interest, attach your CV, and ask whether they anticipate openings.

Timing matters. Contacting a PI within the first year of a new award is ideal, as this is when they are most likely to be recruiting. If you find multiple promising PIs in the same field, prioritize those with the most recent award notices and activity codes that support trainee positions such as R01, U01, or P-series grants.

Frequently Asked Questions About PI Search

What does the opportunity score mean?

The opportunity score is a heuristic that combines award recency, funding amount, activity code type, and project characteristics to estimate how actionable a result might be for job seekers or collaborators. Higher scores suggest stronger signals, but always verify by reading the abstract and checking the PI's current lab page.

Why can't I find a PI I know has funding?

Name variations are the most common cause. Try searching with just the last name, or use different formats like "Smith, John" versus "John Smith." Some PIs also publish under different name variations or may have awards under a previous institutional affiliation.

Does this tool show all NIH-funded PIs?

The tool searches NIH RePORTER data for the keyword and year range you specify. It returns PIs whose funded projects match your search terms. PIs with grants in unrelated areas or whose projects use different terminology will not appear in keyword-filtered results.

What is the difference between "Likely hiring" and "Training-friendly" filters?

"Likely hiring" flags PIs with large new awards or activity codes typically associated with lab expansion. "Training-friendly" identifies awards that include training components or are at institutions known for postdoctoral programs. Both are heuristic filters to help prioritize your outreach.

How to use this well

Start broad, then narrow. Search a field first, then refine by timeframe once you understand who is currently active.

After you find a promising PI, cross-check them in Check PI Funding and review their institution, mechanism type, and project abstracts before reaching out.

What a match means

A result means the keyword appears relevant to the funded project data we searched. It does not guarantee the PI is hiring or that the grant is still active.

Use the abstract, award year, mechanism, and organization context to decide whether the record is strategically relevant.

Data limits

NIH records can lag, institutional names can vary, and some investigators publish or file awards under multiple name formats.

For details on source coverage and refresh cadence, read Data & Methodology.

Related guides

Companion guides for turning a PI search result into useful outreach or a job lead.

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A tactical job-search guide for identifying recently funded labs, judging fit, and timing outreach to principal investigators.

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How to Contact a PI: Finding Emails and Crafting the Perfect Message

Emailing strategies, outreach examples, and a workflow for turning NIH funding signals into focused PI conversations.

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How to Read a New NIH Award Like a Hiring Signal

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Recently Funded Labs in Trending Areas

Principal investigators who received NIH awards in the last 90 days, organized by research area. Use this as a starting point for postdoc searches, collaborator outreach, or competitor scans. Counts and labs refresh daily.

Alzheimer's disease

Neurodegeneration, biomarkers, and disease-modifying therapies.

  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $101,153 · awarded Feb 25, 2026 · 3U01AG084514-01A1S1
  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $3,086,339 · awarded Feb 19, 2026 · 1U01AG084514-01A1
  • Jonathan Haines — CASE WESTERN RESERVE UNIVERSITY, OH
    Alzheimer Disease Genetic Analysis to Identify Potential Therapeutic Targets (ADAPTT)
    $1,256,627 · awarded Feb 4, 2026 · 1R01AG096172-01
  • HARALD SONTHEIMER — UNIVERSITY OF VIRGINIA, VA
    Extracellular matrix and memory impairments in Alzheimer disease
    $709,066 · awarded Apr 7, 2026 · 5R01AG085359-03
  • Keith Josephs — MAYO CLINIC ROCHESTER, MN
    The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies
    $643,670 · awarded Apr 1, 2026 · 5R01DC014942-09
Search more PIs in Alzheimer's disease →

CRISPR & gene editing

Therapeutic gene editing, base editing, and prime editing.

  • Claire Clelland — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA
    CRISPR for tauopathy
    $680,792 · awarded Jan 30, 2026 · 1R01AG092420-01
  • Changchun Liu — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT
    Asymmetric CRISPR Approach for Nucleic Acid Quantification
    $643,849 · awarded Mar 30, 2026 · 2R01EB023607-06A1
  • William Pu — BOSTON CHILDREN'S HOSPITAL, MA
    A modular system for murine CRISPR genome and epigenome editing
    $202,920 · awarded Mar 27, 2026 · 5R21OD037909-02
  • Naama Aviram — SLOAN-KETTERING INST CAN RESEARCH, NY
    Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systems
    $249,000 · awarded Apr 2, 2026 · 5R00GM148720-04
  • Mats Ljungman — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Precision targeting of bladder cancer using CRISPR
    $582,849 · awarded Feb 17, 2026 · 5R01CA285730-03
Search more PIs in CRISPR & gene editing →

Cancer immunotherapy

Checkpoint inhibitors, CAR-T, TIL therapy, and beyond.

  • TERRY SHEPPARD — KEYSTONE SYMPOSIA, CO
    Cancer Immunotherapy: Basic Mechanisms Informing Clinical Applications & Combinations
    $5,000 · awarded Mar 3, 2026 · 1R13CA310704-01
  • Veronika Fedirko — UNIVERSITY OF TX MD ANDERSON CAN CTR, TX
    Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma
    $927,329 · awarded Mar 3, 2026 · 5R01CA255322-05
  • Yuwen Zhu — UNIVERSITY OF COLORADO DENVER, CO
    The GPR171 pathway in cancer immunotherapy
    $355,706 · awarded Apr 2, 2026 · 5R01CA279398-04
  • Wei Hu — YALE UNIVERSITY, CT
    Novel Treg inactivating approach for cancer immunotherapy via targeted protein degradation
    $482,312 · awarded Apr 6, 2026 · 1R01CA295942-01A1
  • Laurent Gapin — UNIVERSITY OF COLORADO DENVER, CO
    Development and Characterization of the MAIT-Boost Knock-In (MBKI) Mouse to Investigate MAIT Cell Biology and Cancer Immunotherapy
    $429,000 · awarded Jan 30, 2026 · 1R21AI195296-01
Search more PIs in Cancer immunotherapy →

GLP-1 & metabolic disease

Diabetes, obesity, and weight-loss therapeutic mechanisms.

  • Xiaomo Xiong — UNIVERSITY OF CINCINNATI, OH
    GLP-1 Agonists for Preventing Alzheimer's Disease in Mild Cognitive Impairment
    $324,000 · awarded Feb 5, 2026 · 1R03AG098738-01
  • STEVEN SCHWENDEMAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Remote Loading of Melanocortin and GLP-1 Peptides in Polymers for Treatment of Obesity
    $231,000 · awarded Apr 17, 2026 · 1R56DK141545-01A1
  • JENNIFER ST SAUVER — MAYO CLINIC ROCHESTER, MN
    Real world impact of glucagon-like peptide receptor agonist (GLP-1 RA) use on older adults
    $443,850 · awarded Mar 13, 2026 · 1R21AG097887-01
  • Naykky Singh Ospina — UNIVERSITY OF FLORIDA, FL
    Navigating the Uncertainties of Thyroid Cancer Risk in GLP-1RA Users
    $694,122 · awarded Mar 24, 2026 · 1R01CA299220-01A1
  • Patricia Grigson — PENNSYLVANIA STATE UNIV HERSHEY MED CTR, PA
    Cocaine Addition and the Need-State Hypothesis
    $667,063 · awarded Feb 26, 2026 · 5R01DA060250-02
Search more PIs in GLP-1 & metabolic disease →

Long COVID

Post-acute sequelae and chronic infection-driven illness.

  • Alexei Tumanov — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX
    Lymphotoxin-dependent control of long COVID
    $234,715 · awarded Feb 13, 2026 · 1R21AI185790-01A1
  • E ELY — VANDERBILT UNIVERSITY MEDICAL CENTER, TN
    REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (with Baricitinib) for Long COVID Related ADRD
    $6,778,156 · awarded Feb 6, 2026 · 5R01AG085873-03
  • Amal Amer — OHIO STATE UNIVERSITY, OH
    Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
    $2,974,582 · awarded Apr 21, 2026 · 5P01AI175399-03
  • Alba Azola — JOHNS HOPKINS UNIVERSITY, MD
    Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 onset ME/CFS versus Pre-Pandemic ME/CFS Patients
    $633,378 · awarded Apr 17, 2026 · 1R01NS147100-01
  • DANIELLE REED — MONELL CHEMICAL SENSES CENTER, PA
    Inflammation and chemosensory loss
    $2,654,249 · awarded Feb 26, 2026 · 1P50DC022549-01A1
Search more PIs in Long COVID →