Steven Emanuel Kahn

UNIVERSITY OF WASHINGTON, SEATTLE, WA

High-opportunity lead · 88/100

Likely hiring

Large award

Very recent

Active award

$1,421,361

FY 2026

Project Title

Diabetes Research Center

Grant Number:

5P30DK017047-50

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

12/1/1996

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The Diabetes Research Center at the University of Washington is part of the national program supported by NIDDK and acts as the focal point and umbrella for diabetes research in the Greater Seattle area. Its mission is to enhance research, education and training in diabetes, obesity, and related dis...

Research Terms

<Adult-Onset Diabetes Mellitus><Area><Basic Research><Basic Science><Bioinformatics><Bioinformatics core><Bioinformatics research core><Bioinformatics resource core><Biomedical Research><Body Weight><Brittle Diabetes Mellitus><Business-Friendly Atmosphere><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Causality><Cell Body><Cell Culture Techniques><Cells><Clinical Research><Clinical Study><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Communities><Complications of Diabetes Mellitus><Confocal Microscopy><Development><Diabetes Complications><Diabetes Mellitus><Diabetes-Related Complications><Diabetic Complications><Direct Costs><Discipline><Disease><Disorder><Dysfunction><Education><Education and Training><Educational aspects><Educational workshop><Ensure><Environment><Etiology><Faculty><Fellowship><Financial Support><Fostering><Functional disorder><Funding><Generations><Goals><Grant><Histopathology><IDDM><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Institution><Insulin-Dependent Diabetes Mellitus><Investigation><Investigators><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Ketosis-Resistant Diabetes Mellitus><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Maturity-Onset Diabetes Mellitus><Metabolic><Mice><Mice Mammals><Mission><Modernization><Murine><Mus><NIDDK><NIDDM><NIH><Names><National Institute of Diabetes and Digestive and Kidney Diseases><National Institutes of Health><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Obesity><Outcome><Pathogenesis><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Peer Review><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Phenotype><Physiopathology><Postdoc><Postdoctoral Fellow><Prevention><Proteomics><Regulation><Research><Research Associate><Research Methodology><Research Methods><Research Personnel><Research Resources><Research Support><Researchers><Resources><Salaries><Scientist><Services><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Sudden-Onset Diabetes Mellitus><Sum><T1 DM><T1 diabetes><T1D><T1DM><T2 DM><T2D><T2DM><Technology><Training><Training and Education><Transgenic Animals><Transgenic Mice><Translating><Translational Research><Translational Science><Type 1 Diabetes Mellitus><Type 1 diabetes><Type 2 Diabetes Mellitus><Type 2 diabetes><Type I Diabetes Mellitus><Type II Diabetes Mellitus><Type II diabetes><Underrepresented Ethnic Minority><Underrepresented Minority><United States National Institutes of Health><Universities><Viral Vector><Wages><Washington><Work><Workshop><adiposity><adult onset diabetes><base><bases><business-friendly environment><causation><cell culture><cell cultures><cell imaging><cellular imaging><clinical care><clinical investigation><collaborative atmosphere><collaborative environment><conference><convention><corpulence><developmental><diabetes><disease causation><disease prevention><disorder prevention><diversity, equity, and inclusiveness><doctoral student><epidemiology research study><epidemiology study><epidemiology survey><equity, diversity, and inclusion><financial aid><financial assistance><glucose metabolism><graduate student><improved><in vivo><innovate><innovation><innovative><insulin dependent diabetes><insulin dependent type 1><interactive atmosphere><interactive environment><interdisciplinary atmosphere><interdisciplinary environment><islet><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><ketosis resistant diabetes><lectures><maturity onset diabetes><molecular imaging><molecule imaging><name><named><naming><pathophysiology><patient oriented outcomes><peer-group atmosphere><peer-group environment><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><programs><research and methods><research associates><response><summit><symposia><symposium><tool><translation research><translational investigation><type 2 DM><type I diabetes><type II DM><type one diabetes><type two diabetes><under-representation of minorities><under-represented minority><underrepresentation of minorities><vector>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

YONG-HUI JIANG

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 88/100

Likely hiring

Large award

Very recent

Active award

$1,379,599

FY 2026

Project Title

MAPT-targeting genome editing therapy for Alzheimer's Disease

Grant Number:

1U01NS145214-01

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Alzheimer’s disease (AD) is a devastating condition without effective treatment. Novel approaches to improving treatment are greatly needed. Accumulating evidence suggests tau as a viable target for AD therapy. Recent preclinical studies have shown promise in tau-targeting molecular therapy through ...

Research Terms

<21+ years old><AD dementia><AD pathology><AD patients><AD therapy><AD treatment><AD3-like protein><AD3LP><Ablation><Achievement><Achievement Attainment><Adult><Adult Human><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's patient><Alzheimer's precursor protein><Alzheimer's therapy><Alzheimers Dementia><Amentia><Amyloid A4 Protein Precursor><Amyloid Protein Precursor><Amyloid beta-Protein Precursor><Amyloid β-Protein Precursor><Angelman Syndrome><Antisense Agent><Antisense Oligonucleotides><Behavioral><Biodistribution><Biological Markers><Brain><Brain Nervous System><Brain Ventricle><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cells><Cerebellomedullary Cistern><Cerebral Dominance><Cerebral Ventricles><Clinic><Clinical><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><DNA mutation><Dementia><Development><Disease><Disease Management><Disorder><Disorder Management><Encephalon><Engineering><Exons><FTD dementia><Formulation><Frontal Temporal Dementia><Frontotemporal Dementia><Generations><Genes><Genetic><Genetic Change><Genetic Induction><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic defect><Genetic mutation><Genetic propensity><Genomics><Guide RNA><Happy Puppet Syndrome><Human><Inherited Predisposition><Inherited Susceptibility><KI mice><Knock-in Mouse><Knock-out><Knockout><Late Onset Alzheimer Disease><Late onset AD><Lead><Link><M mulatta><M. mulatta><MAPT gene><MAPT protein><MT-bound tau><MTBT1><Macaca mulatta><Macaca rhesus><Mediating><Mice><Mice Mammals><Modern Man><Monitor><Murine><Mus><Mutation><NIH><National Institutes of Health><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neural Stem Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron Degeneration><Neurons><Onset of illness><PET><PET Scan><PET imaging><PETSCAN><PETT><PSEN1><PSEN2><Pathogenesis><Patients><Pb element><Persons><Phase><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Preventative therapy><Preventive therapy><Primary Senile Degenerative Dementia><Public Health><Puppet Children><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Splicing><Rad.-PET><Regimen><Reporting><Research Grants><Research Project Grants><Research Projects><Rhesus Macaque><Rhesus Monkey><Ribonucleoproteins><S182 protein><Safety><Severities><Splicing><Stimulus><Syndrome><System><Tauopathies><Technology><Testing><Therapeutic><Therapeutic Effect><Therapeutic Gene Editing><Toxicology><Treatment Efficacy><United States National Institutes of Health><Validation><Work><aberrant tau><aberrant tau protein><abeta deposition><abnormal tau><abnormal tau protein><adulthood><amyloid beta deposition><amyloid precursor protein><amyloid β deposition><antisense oligo><aβ deposition><bio-markers><biologic marker><biomarker><brain laterality><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cerebral lateralization><cisterna magna><clinical applicability><clinical application><clinical translation><clinically translatable><customized therapy><customized treatment><design><designing><developmental><disease onset><disorder onset><effective therapy><effective treatment><familial AD><familial Alzheimer><familial Alzheimer disease><front temporal dementia><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><gRNA><gene-editing therapy><genetic vulnerability><genetically predisposed><genome editing><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genome mutation><genomic editing><heavy metal Pb><heavy metal lead><hemispheric specialization><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><intervention efficacy><knockin mice><late onset alzheimer><microtubule associated protein tau><microtubule associated protein tau mutation><microtubule bound tau><microtubule-associated protein tau><microtubule-associated protein tau mutation><microtubule-bound tau><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mouse model><murine model><mutant tau><mutant tau protein><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><neonate><nerve stem cell><neural degeneration><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodegeneration><neurodegenerative><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neurological degeneration><neuron progenitors><neuronal><neuronal degeneration><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuropathologic tau><neuropathological tau><neuroprogenitor><new approaches><next generation><non-human primate><nonhuman primate><novel><novel approaches><novel strategies><novel strategy><pathogenic tau><pathogenic tau gene mutation><pathogenic tau protein><pathological change in tau><pathological tau><pathological tau protein><patient living with Alzheimer's disease><patient specific therapies><patient specific treatment><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical study><preclinical study><presenilin 1 protein><presenilin 2 protein><presenilin-1><presenilin-2><preservation><primary degenerative dementia><progenitor and neural stem cells><programs><puppetlike syndrome><senile dementia of the Alzheimer type><somatic cell gene editing><somatic cell genome editing><somatic gene editing><somatic genome editing><success><tailored medical treatment><tailored therapy><tailored treatment><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau abnormality><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau intronic mutation><tau mediated neurodegeneration><tau mutation><tau neurodegenerative disease><tau neuropathology><tau pathological change><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><technology platform><technology system><therapeutic editing><therapeutic efficacy><therapeutic genome editing><therapeutic target><therapy efficacy><treatment effect><treatment strategy><unique treatment><validations><τ Proteins><τ mutation>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

STEPHEN M STRITTMATTER

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 88/100

Likely hiring

Large award

Very recent

Active award

$1,379,599

FY 2026

Project Title

MAPT-targeting genome editing therapy for Alzheimer's Disease

Grant Number:

1U01NS145214-01

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Alzheimer’s disease (AD) is a devastating condition without effective treatment. Novel approaches to improving treatment are greatly needed. Accumulating evidence suggests tau as a viable target for AD therapy. Recent preclinical studies have shown promise in tau-targeting molecular therapy through ...

Research Terms

<21+ years old><AD dementia><AD pathology><AD patients><AD therapy><AD treatment><AD3-like protein><AD3LP><Ablation><Achievement><Achievement Attainment><Adult><Adult Human><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's patient><Alzheimer's precursor protein><Alzheimer's therapy><Alzheimers Dementia><Amentia><Amyloid A4 Protein Precursor><Amyloid Protein Precursor><Amyloid beta-Protein Precursor><Amyloid β-Protein Precursor><Angelman Syndrome><Antisense Agent><Antisense Oligonucleotides><Behavioral><Biodistribution><Biological Markers><Brain><Brain Nervous System><Brain Ventricle><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cells><Cerebellomedullary Cistern><Cerebral Dominance><Cerebral Ventricles><Clinic><Clinical><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><DNA mutation><Dementia><Development><Disease><Disease Management><Disorder><Disorder Management><Encephalon><Engineering><Exons><FTD dementia><Formulation><Frontal Temporal Dementia><Frontotemporal Dementia><Generations><Genes><Genetic><Genetic Change><Genetic Induction><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic defect><Genetic mutation><Genetic propensity><Genomics><Guide RNA><Happy Puppet Syndrome><Human><Inherited Predisposition><Inherited Susceptibility><KI mice><Knock-in Mouse><Knock-out><Knockout><Late Onset Alzheimer Disease><Late onset AD><Lead><Link><M mulatta><M. mulatta><MAPT gene><MAPT protein><MT-bound tau><MTBT1><Macaca mulatta><Macaca rhesus><Mediating><Mice><Mice Mammals><Modern Man><Monitor><Murine><Mus><Mutation><NIH><National Institutes of Health><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neural Stem Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron Degeneration><Neurons><Onset of illness><PET><PET Scan><PET imaging><PETSCAN><PETT><PSEN1><PSEN2><Pathogenesis><Patients><Pb element><Persons><Phase><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Preventative therapy><Preventive therapy><Primary Senile Degenerative Dementia><Public Health><Puppet Children><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Splicing><Rad.-PET><Regimen><Reporting><Research Grants><Research Project Grants><Research Projects><Rhesus Macaque><Rhesus Monkey><Ribonucleoproteins><S182 protein><Safety><Severities><Splicing><Stimulus><Syndrome><System><Tauopathies><Technology><Testing><Therapeutic><Therapeutic Effect><Therapeutic Gene Editing><Toxicology><Treatment Efficacy><United States National Institutes of Health><Validation><Work><aberrant tau><aberrant tau protein><abeta deposition><abnormal tau><abnormal tau protein><adulthood><amyloid beta deposition><amyloid precursor protein><amyloid β deposition><antisense oligo><aβ deposition><bio-markers><biologic marker><biomarker><brain laterality><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cerebral lateralization><cisterna magna><clinical applicability><clinical application><clinical translation><clinically translatable><customized therapy><customized treatment><design><designing><developmental><disease onset><disorder onset><effective therapy><effective treatment><familial AD><familial Alzheimer><familial Alzheimer disease><front temporal dementia><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><gRNA><gene-editing therapy><genetic vulnerability><genetically predisposed><genome editing><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genome mutation><genomic editing><heavy metal Pb><heavy metal lead><hemispheric specialization><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><intervention efficacy><knockin mice><late onset alzheimer><microtubule associated protein tau><microtubule associated protein tau mutation><microtubule bound tau><microtubule-associated protein tau><microtubule-associated protein tau mutation><microtubule-bound tau><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mouse model><murine model><mutant tau><mutant tau protein><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><neonate><nerve stem cell><neural degeneration><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodegeneration><neurodegenerative><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neurological degeneration><neuron progenitors><neuronal><neuronal degeneration><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuropathologic tau><neuropathological tau><neuroprogenitor><new approaches><next generation><non-human primate><nonhuman primate><novel><novel approaches><novel strategies><novel strategy><pathogenic tau><pathogenic tau gene mutation><pathogenic tau protein><pathological change in tau><pathological tau><pathological tau protein><patient living with Alzheimer's disease><patient specific therapies><patient specific treatment><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical study><preclinical study><presenilin 1 protein><presenilin 2 protein><presenilin-1><presenilin-2><preservation><primary degenerative dementia><progenitor and neural stem cells><programs><puppetlike syndrome><senile dementia of the Alzheimer type><somatic cell gene editing><somatic cell genome editing><somatic gene editing><somatic genome editing><success><tailored medical treatment><tailored therapy><tailored treatment><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau abnormality><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau intronic mutation><tau mediated neurodegeneration><tau mutation><tau neurodegenerative disease><tau neuropathology><tau pathological change><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><technology platform><technology system><therapeutic editing><therapeutic efficacy><therapeutic genome editing><therapeutic target><therapy efficacy><treatment effect><treatment strategy><unique treatment><validations><τ Proteins><τ mutation>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kevin Navin Sheth

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 88/100

Likely hiring

Large award

Very recent

Active award

$1,379,599

FY 2026

Project Title

MAPT-targeting genome editing therapy for Alzheimer's Disease

Grant Number:

1U01NS145214-01

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Alzheimer’s disease (AD) is a devastating condition without effective treatment. Novel approaches to improving treatment are greatly needed. Accumulating evidence suggests tau as a viable target for AD therapy. Recent preclinical studies have shown promise in tau-targeting molecular therapy through ...

Research Terms

<21+ years old><AD dementia><AD pathology><AD patients><AD therapy><AD treatment><AD3-like protein><AD3LP><Ablation><Achievement><Achievement Attainment><Adult><Adult Human><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's patient><Alzheimer's precursor protein><Alzheimer's therapy><Alzheimers Dementia><Amentia><Amyloid A4 Protein Precursor><Amyloid Protein Precursor><Amyloid beta-Protein Precursor><Amyloid β-Protein Precursor><Angelman Syndrome><Antisense Agent><Antisense Oligonucleotides><Behavioral><Biodistribution><Biological Markers><Brain><Brain Nervous System><Brain Ventricle><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cells><Cerebellomedullary Cistern><Cerebral Dominance><Cerebral Ventricles><Clinic><Clinical><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><DNA mutation><Dementia><Development><Disease><Disease Management><Disorder><Disorder Management><Encephalon><Engineering><Exons><FTD dementia><Formulation><Frontal Temporal Dementia><Frontotemporal Dementia><Generations><Genes><Genetic><Genetic Change><Genetic Induction><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic defect><Genetic mutation><Genetic propensity><Genomics><Guide RNA><Happy Puppet Syndrome><Human><Inherited Predisposition><Inherited Susceptibility><KI mice><Knock-in Mouse><Knock-out><Knockout><Late Onset Alzheimer Disease><Late onset AD><Lead><Link><M mulatta><M. mulatta><MAPT gene><MAPT protein><MT-bound tau><MTBT1><Macaca mulatta><Macaca rhesus><Mediating><Mice><Mice Mammals><Modern Man><Monitor><Murine><Mus><Mutation><NIH><National Institutes of Health><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neural Stem Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron Degeneration><Neurons><Onset of illness><PET><PET Scan><PET imaging><PETSCAN><PETT><PSEN1><PSEN2><Pathogenesis><Patients><Pb element><Persons><Phase><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Preventative therapy><Preventive therapy><Primary Senile Degenerative Dementia><Public Health><Puppet Children><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Splicing><Rad.-PET><Regimen><Reporting><Research Grants><Research Project Grants><Research Projects><Rhesus Macaque><Rhesus Monkey><Ribonucleoproteins><S182 protein><Safety><Severities><Splicing><Stimulus><Syndrome><System><Tauopathies><Technology><Testing><Therapeutic><Therapeutic Effect><Therapeutic Gene Editing><Toxicology><Treatment Efficacy><United States National Institutes of Health><Validation><Work><aberrant tau><aberrant tau protein><abeta deposition><abnormal tau><abnormal tau protein><adulthood><amyloid beta deposition><amyloid precursor protein><amyloid β deposition><antisense oligo><aβ deposition><bio-markers><biologic marker><biomarker><brain laterality><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cerebral lateralization><cisterna magna><clinical applicability><clinical application><clinical translation><clinically translatable><customized therapy><customized treatment><design><designing><developmental><disease onset><disorder onset><effective therapy><effective treatment><familial AD><familial Alzheimer><familial Alzheimer disease><front temporal dementia><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><gRNA><gene-editing therapy><genetic vulnerability><genetically predisposed><genome editing><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genome mutation><genomic editing><heavy metal Pb><heavy metal lead><hemispheric specialization><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><intervention efficacy><knockin mice><late onset alzheimer><microtubule associated protein tau><microtubule associated protein tau mutation><microtubule bound tau><microtubule-associated protein tau><microtubule-associated protein tau mutation><microtubule-bound tau><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mouse model><murine model><mutant tau><mutant tau protein><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><neonate><nerve stem cell><neural degeneration><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodegeneration><neurodegenerative><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neurological degeneration><neuron progenitors><neuronal><neuronal degeneration><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuropathologic tau><neuropathological tau><neuroprogenitor><new approaches><next generation><non-human primate><nonhuman primate><novel><novel approaches><novel strategies><novel strategy><pathogenic tau><pathogenic tau gene mutation><pathogenic tau protein><pathological change in tau><pathological tau><pathological tau protein><patient living with Alzheimer's disease><patient specific therapies><patient specific treatment><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical study><preclinical study><presenilin 1 protein><presenilin 2 protein><presenilin-1><presenilin-2><preservation><primary degenerative dementia><progenitor and neural stem cells><programs><puppetlike syndrome><senile dementia of the Alzheimer type><somatic cell gene editing><somatic cell genome editing><somatic gene editing><somatic genome editing><success><tailored medical treatment><tailored therapy><tailored treatment><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau abnormality><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau intronic mutation><tau mediated neurodegeneration><tau mutation><tau neurodegenerative disease><tau neuropathology><tau pathological change><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><technology platform><technology system><therapeutic editing><therapeutic efficacy><therapeutic genome editing><therapeutic target><therapy efficacy><treatment effect><treatment strategy><unique treatment><validations><τ Proteins><τ mutation>

View Full Project Details on NIH Reporter

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Jiangbing Zhou

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 88/100

Likely hiring

Large award

Very recent

Active award

$1,379,599

FY 2026

Project Title

MAPT-targeting genome editing therapy for Alzheimer's Disease

Grant Number:

1U01NS145214-01

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Alzheimer’s disease (AD) is a devastating condition without effective treatment. Novel approaches to improving treatment are greatly needed. Accumulating evidence suggests tau as a viable target for AD therapy. Recent preclinical studies have shown promise in tau-targeting molecular therapy through ...

Research Terms

<21+ years old><AD dementia><AD pathology><AD patients><AD therapy><AD treatment><AD3-like protein><AD3LP><Ablation><Achievement><Achievement Attainment><Adult><Adult Human><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's patient><Alzheimer's precursor protein><Alzheimer's therapy><Alzheimers Dementia><Amentia><Amyloid A4 Protein Precursor><Amyloid Protein Precursor><Amyloid beta-Protein Precursor><Amyloid β-Protein Precursor><Angelman Syndrome><Antisense Agent><Antisense Oligonucleotides><Behavioral><Biodistribution><Biological Markers><Brain><Brain Nervous System><Brain Ventricle><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cells><Cerebellomedullary Cistern><Cerebral Dominance><Cerebral Ventricles><Clinic><Clinical><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><DNA mutation><Dementia><Development><Disease><Disease Management><Disorder><Disorder Management><Encephalon><Engineering><Exons><FTD dementia><Formulation><Frontal Temporal Dementia><Frontotemporal Dementia><Generations><Genes><Genetic><Genetic Change><Genetic Induction><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic defect><Genetic mutation><Genetic propensity><Genomics><Guide RNA><Happy Puppet Syndrome><Human><Inherited Predisposition><Inherited Susceptibility><KI mice><Knock-in Mouse><Knock-out><Knockout><Late Onset Alzheimer Disease><Late onset AD><Lead><Link><M mulatta><M. mulatta><MAPT gene><MAPT protein><MT-bound tau><MTBT1><Macaca mulatta><Macaca rhesus><Mediating><Mice><Mice Mammals><Modern Man><Monitor><Murine><Mus><Mutation><NIH><National Institutes of Health><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neural Stem Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron Degeneration><Neurons><Onset of illness><PET><PET Scan><PET imaging><PETSCAN><PETT><PSEN1><PSEN2><Pathogenesis><Patients><Pb element><Persons><Phase><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Preventative therapy><Preventive therapy><Primary Senile Degenerative Dementia><Public Health><Puppet Children><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Splicing><Rad.-PET><Regimen><Reporting><Research Grants><Research Project Grants><Research Projects><Rhesus Macaque><Rhesus Monkey><Ribonucleoproteins><S182 protein><Safety><Severities><Splicing><Stimulus><Syndrome><System><Tauopathies><Technology><Testing><Therapeutic><Therapeutic Effect><Therapeutic Gene Editing><Toxicology><Treatment Efficacy><United States National Institutes of Health><Validation><Work><aberrant tau><aberrant tau protein><abeta deposition><abnormal tau><abnormal tau protein><adulthood><amyloid beta deposition><amyloid precursor protein><amyloid β deposition><antisense oligo><aβ deposition><bio-markers><biologic marker><biomarker><brain laterality><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cerebral lateralization><cisterna magna><clinical applicability><clinical application><clinical translation><clinically translatable><customized therapy><customized treatment><design><designing><developmental><disease onset><disorder onset><effective therapy><effective treatment><familial AD><familial Alzheimer><familial Alzheimer disease><front temporal dementia><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><gRNA><gene-editing therapy><genetic vulnerability><genetically predisposed><genome editing><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genome mutation><genomic editing><heavy metal Pb><heavy metal lead><hemispheric specialization><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><intervention efficacy><knockin mice><late onset alzheimer><microtubule associated protein tau><microtubule associated protein tau mutation><microtubule bound tau><microtubule-associated protein tau><microtubule-associated protein tau mutation><microtubule-bound tau><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mouse model><murine model><mutant tau><mutant tau protein><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><neonate><nerve stem cell><neural degeneration><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodegeneration><neurodegenerative><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neurological degeneration><neuron progenitors><neuronal><neuronal degeneration><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuropathologic tau><neuropathological tau><neuroprogenitor><new approaches><next generation><non-human primate><nonhuman primate><novel><novel approaches><novel strategies><novel strategy><pathogenic tau><pathogenic tau gene mutation><pathogenic tau protein><pathological change in tau><pathological tau><pathological tau protein><patient living with Alzheimer's disease><patient specific therapies><patient specific treatment><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical study><preclinical study><presenilin 1 protein><presenilin 2 protein><presenilin-1><presenilin-2><preservation><primary degenerative dementia><progenitor and neural stem cells><programs><puppetlike syndrome><senile dementia of the Alzheimer type><somatic cell gene editing><somatic cell genome editing><somatic gene editing><somatic genome editing><success><tailored medical treatment><tailored therapy><tailored treatment><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau abnormality><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau intronic mutation><tau mediated neurodegeneration><tau mutation><tau neurodegenerative disease><tau neuropathology><tau pathological change><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><technology platform><technology system><therapeutic editing><therapeutic efficacy><therapeutic genome editing><therapeutic target><therapy efficacy><treatment effect><treatment strategy><unique treatment><validations><τ Proteins><τ mutation>

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Jeffrey Ohmann Bush

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

High-opportunity lead · 80/100

Likely hiring

Large award

Very recent

Active award

$1,032,684

FY 2026

Project Title

Signaling control and cellular basis of craniofacial morphogenesis and congenital disease

Grant Number:

5R35DE031926-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Congenital craniofacial anomalies are common and arise from cellular changes that cause aberrant tissue-level alterations in shape. Though significant understanding of the gene regulatory networks that pattern craniofacial development has been achieved, knowledge regarding the cellul...

Research Terms

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Megan Sykes

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Large award

Active award

Team-scale grant

$3,278,603

FY 2026

Project Title

A Tolerance Approach to Xenotransplantation

Grant Number:

5P01AI045897-25

Activity Code:

P01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2000

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

This proposal represents the renewal of a highly integrated PPG aimed at induction of tolerance to porcine organs transplanted into primates. We propose to combine two unique tolerance induction platforms, one based on mixed hematopoietic chimerism and the other on vascularized thymus transplantatio...

Research Terms

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Mark S Anderson

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

High-opportunity lead · 74/100

Likely hiring

Large award

Active award

Team-scale grant

$1,764,521

FY 2026

Project Title

STAT3 variants as a rheostat of immune tolerance

Grant Number:

5P01AI155393-05

Activity Code:

P01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/17/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary/Abstract (Overall) Dysregulation of the immune system can have severe consequences on health and wellbeing. Although this is often a complex process, recent progress in human genetics has allowed for the identification of single gene variants that are strongly associated with immune ...

Research Terms

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RONALD ANTHONY DEPINHO

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Recent

Active award

$967,037

FY 2026

Project Title

Identifying and targeting collateral lethal vulnerabilities in cancers

Grant Number:

5U01CA275886-04

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Identifying and targeting collateral lethal vulnerabilities in cancers Abstract/Summary Genomic deletions targeting major tumor suppressor genes frequently include adjacent passenger genes, encoding cell essential housekeeping functions. These cancer cells survive due to co-expressing functionally r...

Research Terms

<1p36><21+ years old><5-Phospho-alpha-D-Ribose 1-Diphosphate Synthetase><ARID1A><ARID1A gene><AT- rich interactive domain-containing protein 1A><AT-rich interactive domain 1A gene><Adult><Adult Human><Alleles><Allelomorphs><Anti-Oncogenes><Antioncogene Protein p53><Antioncogenes><Apoptotic><Assay><Bioassay><Biochemical><Biological><Biological Assay><CDK4I><CDKN2><CDKN2 Genes><CDKN2A><CDKN2A gene><CDP Diacylglycerol-Serine O-Phosphatidyltransferase><CDP Diglyceride Serine O-Phosphatidyltransferase><CDP-DG Synthase><CDPdiacylglycerol-Serine O-Phosphatidyltransferase><CMM2><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Suppressor Genes><Cancer Treatment><Cancer cell line><Cancers><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Function><Cell Growth in Number><Cell Line><Cell Multiplication><Cell Physiology><Cell Process><Cell Proliferation><Cell Signaling><Cell Survival><Cell Viability><Cell division><CellLine><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Proliferation><Cellular Tumor Antigen P53><Chromosomes><Cleavage Stimulation Factor><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Common Neoplasm><Common Tumor><Complex><Computer Analysis><Computing Methodologies><Coupled><CstF Protein><Cultured Cells><Cyclin-Dependent Kinase Inhibitor 2A Gene><DPC4><Data><Defect><Deleted in Pancreatic Carcinoma><Deletion of DNA Sequences><Dependence><Diphosphates><Drosophila Homolog of Mothers Against Decapentaplegic 4><EC 1.1.1.27><Emerogenes><Endoplasmic Reticulum><Engineering><Enzyme Gene><Enzymes><Ergastoplasm><Event><Extinction><Face><Gene Deletion><Gene Family><Gene Transcription><Genes><Genetic><Genetic Transcription><Genome><Goals><Housekeeping><Housework><Human><INK4><INK4A><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Individual><Intermediary Metabolism><Intracellular Communication and Signaling><Knock-out><Knockout><L-Lactate Dehydrogenase><L-Lactic Acid Dehydrogenase><Lactate Dehydrogenase><Ligase><Ligase Gene><M Phase><MADH4><MADH4 gene><MMAC1><MMAC1 protein><MTS1><MTS1 Genes><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mammalian Cell><Maps><Measurement><Measures><Mediating><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Mitochondria><Mitosis><Mitosis Stage><Mitotic spindle><Modeling><Modern Man><Monitor><Murine><Mus><Mutated in Multiple Advanced Cancers 1><NAD-Lactate Dehydrogenase><NF-1><NF-1 Protein><NF-1 encoded protein><NF1><NF1 GRP><NF1 Protein><NF1 gene><NF1 tumor suppressor><NF1-GAP-Related Protein><Neurofibromatosis 1 Genes><Neurofibromatosis Type 1 Gene Product><Neurofibromatosis Type 1 Protein><Neurofibromin><Neurofibromin 1><Normal Cell><Nuclear Envelope><Nuclear Membrane><Nucleotide Synthesis><Onco-Suppressor Genes><Oncogenes-Tumor Suppressors><Oncoprotein p53><Organoids><Ortholog><Orthologous Gene><P53><PHTS gene><PHTS protein><PRPP Synthetase><PRibPP Synthetase><PTEN><PTEN gene><PTEN protein><PTEN1><Patients><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Phosphatidylserine Synthase><Phosphatidylserine Synthetase><Phosphatidylserines><Phosphoprotein P53><Phosphoprotein pp53><Phosphoribosyl Pyrophosphate Synthetase><Polyadenylation><Pre-mRNA><Precision cancer therapy><Precision cancer treatment><Probability><Protein TP53><Proteins><Proteomics><Purines/Pyrimidines/Nucleotides/Nucleic Acids Metabolism><Pyrophosphates><Pyruvate><RB1><RB1 gene><RNA Expression><RNA Polyadenylation><RNA, Messenger, Precursors><Recessive Oncogenes><Reiterated Genes><Ribose-Phosphate Pyrophosphokinase><Ribosephosphate Pyrophosphokinase><SMA- and MAD-Related Protein 4><SMAD4><SYS-TX><Sample Size><Sequence Deletion><Serine Phosphoglycerides><Signal Transduction><Signal Transduction Systems><Signaling><Strains Cell Lines><Subcellular Process><Survival Analyses><Survival Analysis><Synthetases><System><Systemic Therapy><TP16><TP53><TP53 gene><TRP53><TSG9A><Toxic effect><Toxicities><Transcription><Tumor Protein p53><Tumor Protein p53 Gene><Tumor Suppressing Genes><Tumor Suppressor Genes><Tumor Suppressor Proteins><U1 RNA><U1 small nuclear RNA><U1 snRNA><Validation><adulthood><anti-cancer therapy><biologic><biological signal transduction><cancer cell><cancer therapy><cancer type><cancer-directed therapy><candidate validation><cell culture><cell cultures><computational analyses><computational analysis><computational methodology><computational methods><computer analyses><computer based method><computer methods><computing method><cultured cell line><deep learning><deep learning method><deep learning strategy><design><designing><drug discovery><entire genome><enzyme activity><faces><facial><full genome><gain of function><gene deletion mutation><gene locus><gene redundancy><genetic locus><genome scale><genome-wide><genomewide><genomic deletion><genomic location><genomic locus><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved outcome><in vivo><lactic acid dehydrogenase><live cell image><live cell imaging><live cellular image><live cellular imaging><mRNA Precursor><malic enzyme><malignancy><member><metabolism measurement><metabolomics><metabonomics><mitochondrial><model organism><mutant><mutated in multiple advanced cancers 1 protein><neoplasm/cancer><neurofibromatosis type 1 gene><neurofibromatosis type 1 protein/gene><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><nf 1 Genes><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><nucleotide metabolism><oncosuppressor gene><overexpress><overexpression><p14ARF><p16 Genes><p16INK4 Genes><p16INK4A Genes><p16INK4a><p53 Antigen><p53 Genes><p53 Tumor Suppressor><paralog><paralogous gene><pharmacologic><phosphatase and tensin homologue on chromosome ten><precision anticancer therapy><precision cancer therapeutic><protein p53><public data base><public database><publicly accessible data base><publicly accessible database><publicly available data base><publicly available database><pyruvic-malic carboxylase><receptor expression><research study><response><retinoblastoma-1><screening><screenings><shRNA><short hairpin RNA><synthetic lethal interaction><synthetic lethality><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><transcriptomics><tumor><tumor suppressor><validation studies><validations><vector><whole genome>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Traver Hart

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Recent

Active award

$967,037

FY 2026

Project Title

Identifying and targeting collateral lethal vulnerabilities in cancers

Grant Number:

5U01CA275886-04

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Identifying and targeting collateral lethal vulnerabilities in cancers Abstract/Summary Genomic deletions targeting major tumor suppressor genes frequently include adjacent passenger genes, encoding cell essential housekeeping functions. These cancer cells survive due to co-expressing functionally r...

Research Terms

<1p36><21+ years old><5-Phospho-alpha-D-Ribose 1-Diphosphate Synthetase><ARID1A><ARID1A gene><AT- rich interactive domain-containing protein 1A><AT-rich interactive domain 1A gene><Adult><Adult Human><Alleles><Allelomorphs><Anti-Oncogenes><Antioncogene Protein p53><Antioncogenes><Apoptotic><Assay><Bioassay><Biochemical><Biological><Biological Assay><CDK4I><CDKN2><CDKN2 Genes><CDKN2A><CDKN2A gene><CDP Diacylglycerol-Serine O-Phosphatidyltransferase><CDP Diglyceride Serine O-Phosphatidyltransferase><CDP-DG Synthase><CDPdiacylglycerol-Serine O-Phosphatidyltransferase><CMM2><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Suppressor Genes><Cancer Treatment><Cancer cell line><Cancers><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Function><Cell Growth in Number><Cell Line><Cell Multiplication><Cell Physiology><Cell Process><Cell Proliferation><Cell Signaling><Cell Survival><Cell Viability><Cell division><CellLine><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Proliferation><Cellular Tumor Antigen P53><Chromosomes><Cleavage Stimulation Factor><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Common Neoplasm><Common Tumor><Complex><Computer Analysis><Computing Methodologies><Coupled><CstF Protein><Cultured Cells><Cyclin-Dependent Kinase Inhibitor 2A Gene><DPC4><Data><Defect><Deleted in Pancreatic Carcinoma><Deletion of DNA Sequences><Dependence><Diphosphates><Drosophila Homolog of Mothers Against Decapentaplegic 4><EC 1.1.1.27><Emerogenes><Endoplasmic Reticulum><Engineering><Enzyme Gene><Enzymes><Ergastoplasm><Event><Extinction><Face><Gene Deletion><Gene Family><Gene Transcription><Genes><Genetic><Genetic Transcription><Genome><Goals><Housekeeping><Housework><Human><INK4><INK4A><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Individual><Intermediary Metabolism><Intracellular Communication and Signaling><Knock-out><Knockout><L-Lactate Dehydrogenase><L-Lactic Acid Dehydrogenase><Lactate Dehydrogenase><Ligase><Ligase Gene><M Phase><MADH4><MADH4 gene><MMAC1><MMAC1 protein><MTS1><MTS1 Genes><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mammalian Cell><Maps><Measurement><Measures><Mediating><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Mitochondria><Mitosis><Mitosis Stage><Mitotic spindle><Modeling><Modern Man><Monitor><Murine><Mus><Mutated in Multiple Advanced Cancers 1><NAD-Lactate Dehydrogenase><NF-1><NF-1 Protein><NF-1 encoded protein><NF1><NF1 GRP><NF1 Protein><NF1 gene><NF1 tumor suppressor><NF1-GAP-Related Protein><Neurofibromatosis 1 Genes><Neurofibromatosis Type 1 Gene Product><Neurofibromatosis Type 1 Protein><Neurofibromin><Neurofibromin 1><Normal Cell><Nuclear Envelope><Nuclear Membrane><Nucleotide Synthesis><Onco-Suppressor Genes><Oncogenes-Tumor Suppressors><Oncoprotein p53><Organoids><Ortholog><Orthologous Gene><P53><PHTS gene><PHTS protein><PRPP Synthetase><PRibPP Synthetase><PTEN><PTEN gene><PTEN protein><PTEN1><Patients><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Phosphatidylserine Synthase><Phosphatidylserine Synthetase><Phosphatidylserines><Phosphoprotein P53><Phosphoprotein pp53><Phosphoribosyl Pyrophosphate Synthetase><Polyadenylation><Pre-mRNA><Precision cancer therapy><Precision cancer treatment><Probability><Protein TP53><Proteins><Proteomics><Purines/Pyrimidines/Nucleotides/Nucleic Acids Metabolism><Pyrophosphates><Pyruvate><RB1><RB1 gene><RNA Expression><RNA Polyadenylation><RNA, Messenger, Precursors><Recessive Oncogenes><Reiterated Genes><Ribose-Phosphate Pyrophosphokinase><Ribosephosphate Pyrophosphokinase><SMA- and MAD-Related Protein 4><SMAD4><SYS-TX><Sample Size><Sequence Deletion><Serine Phosphoglycerides><Signal Transduction><Signal Transduction Systems><Signaling><Strains Cell Lines><Subcellular Process><Survival Analyses><Survival Analysis><Synthetases><System><Systemic Therapy><TP16><TP53><TP53 gene><TRP53><TSG9A><Toxic effect><Toxicities><Transcription><Tumor Protein p53><Tumor Protein p53 Gene><Tumor Suppressing Genes><Tumor Suppressor Genes><Tumor Suppressor Proteins><U1 RNA><U1 small nuclear RNA><U1 snRNA><Validation><adulthood><anti-cancer therapy><biologic><biological signal transduction><cancer cell><cancer therapy><cancer type><cancer-directed therapy><candidate validation><cell culture><cell cultures><computational analyses><computational analysis><computational methodology><computational methods><computer analyses><computer based method><computer methods><computing method><cultured cell line><deep learning><deep learning method><deep learning strategy><design><designing><drug discovery><entire genome><enzyme activity><faces><facial><full genome><gain of function><gene deletion mutation><gene locus><gene redundancy><genetic locus><genome scale><genome-wide><genomewide><genomic deletion><genomic location><genomic locus><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved outcome><in vivo><lactic acid dehydrogenase><live cell image><live cell imaging><live cellular image><live cellular imaging><mRNA Precursor><malic enzyme><malignancy><member><metabolism measurement><metabolomics><metabonomics><mitochondrial><model organism><mutant><mutated in multiple advanced cancers 1 protein><neoplasm/cancer><neurofibromatosis type 1 gene><neurofibromatosis type 1 protein/gene><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><nf 1 Genes><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><nucleotide metabolism><oncosuppressor gene><overexpress><overexpression><p14ARF><p16 Genes><p16INK4 Genes><p16INK4A Genes><p16INK4a><p53 Antigen><p53 Genes><p53 Tumor Suppressor><paralog><paralogous gene><pharmacologic><phosphatase and tensin homologue on chromosome ten><precision anticancer therapy><precision cancer therapeutic><protein p53><public data base><public database><publicly accessible data base><publicly accessible database><publicly available data base><publicly available database><pyruvic-malic carboxylase><receptor expression><research study><response><retinoblastoma-1><screening><screenings><shRNA><short hairpin RNA><synthetic lethal interaction><synthetic lethality><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><transcriptomics><tumor><tumor suppressor><validation studies><validations><vector><whole genome>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Steven K. Reilly

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$791,465

FY 2026

Project Title

Multi-scale functional dissection and modeling of regulatory variation associated with human traits

Grant Number:

5R01HG012872-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/16/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Our ability to identify genetic sequence variation in humans has thus far outstripped the field’s ability to interpret these mutations. Genome-wide association studies have identified hundreds of thousands of genomic loci associated with disease risk and human phenotypic traits, yet in few instances...

Research Terms

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Samantha A Brugmann

JACKSON LABORATORY, BAR HARBOR, ME

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$757,088

FY 2026

Project Title

Predicting Tissue Specific Gli3 Regulatory Activity Using Hand2

Grant Number:

5R01DE031750-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/16/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The Hedgehog (Hh) signaling pathway is essential for normal embryonic development and when perturbed, frequently results in human disease, including those that impact development of the craniofacial complex. The Gli transcription factors are the downstream effectors of the pathway an...

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Kevin Anthony Peterson

JACKSON LABORATORY, BAR HARBOR, ME

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$757,088

FY 2026

Project Title

Predicting Tissue Specific Gli3 Regulatory Activity Using Hand2

Grant Number:

5R01DE031750-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/16/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The Hedgehog (Hh) signaling pathway is essential for normal embryonic development and when perturbed, frequently results in human disease, including those that impact development of the craniofacial complex. The Gli transcription factors are the downstream effectors of the pathway an...

Research Terms

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Wenhui Hu

TEXAS BIOMEDICAL RESEARCH INSTITUTE, SAN ANTONIO, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$754,354

FY 2026

Project Title

Brain myeloid cell-targeted multiplexed gene editing for SIV/HIV eradication

Grant Number:

5R01MH130193-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/5/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The long-lived myeloid cells such as perivascular macrophages and microglia in the central nervous system (CNS) persistently harbor HIV. These infected cells could contribute to the source of residual viremia during long-term antiretroviral therapy (ART) or to rebounding virus upon ...

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Binhua Julie Ling

TEXAS BIOMEDICAL RESEARCH INSTITUTE, SAN ANTONIO, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$754,354

FY 2026

Project Title

Brain myeloid cell-targeted multiplexed gene editing for SIV/HIV eradication

Grant Number:

5R01MH130193-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/5/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The long-lived myeloid cells such as perivascular macrophages and microglia in the central nervous system (CNS) persistently harbor HIV. These infected cells could contribute to the source of residual viremia during long-term antiretroviral therapy (ART) or to rebounding virus upon ...

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BRIAN Joseph MITCHELL

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$726,576

FY 2026

Project Title

Identification and characterization of novel genes causative for primary ciliary dyskinesia

Grant Number:

5R01HL173147-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/10/2024

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Primary Ciliary Dyskinesia (PCD) is a rare genetic disorder that affects multiple tissues leading to increased risk for situs inversus, infertility, hydrocephalus and respiratory disease. In the lung, PCD phenotypes are driven by the failure of multi-ciliated cells (MCCs) to generate...

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Yanling Wang

RUSH UNIVERSITY MEDICAL CENTER, CHICAGO, IL

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$700,994

FY 2026

Project Title

Uncovering cell-type-specific driver genes of Alzheimer's Disease by pathology-indexing scRNA-seq, spatial transcriptomics, and CRISPR screens

Grant Number:

5R01AG074082-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Although amyloid-β plaques and neurofibrillary tangles are the current criteria for pathologic diagnosis of Alzheimer’s Diseases (AD), only 9% of clinically diagnosed AD patients have "pure" AD pathology and most AD cases have mixed pathologies, which significantly increase the odds ...

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Cynthia Casson Morton

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$693,926

FY 2026

Project Title

Genetic Approach to Therapy for DFNA9

Grant Number:

5R01DC021104-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/20/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT/PROJECT SUMMARY Impressive advances in gene discovery in the auditory system have occurred in the last decades, making specific targeted approaches for therapeutics realistic goals of great interest in the field of hearing and deafness. Hearing loss (HL) is an increasingly significant healt...

Research Terms

<21+ years old><Adult><Adult Human><Age><Alleles><Allelomorphs><Auditory system><Biological><Biology><Body Tissues><Boston><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CX26><Cas nuclease technology><Categories><Characteristics><Children's Hospital><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Connexin-26><DNA><DNA Therapy><DNA mutation><Deoxyribonucleic Acid><Dermal><Dermatologic biopsy><Development><Disease><Disorder><Dysfunction><Early Intervention><Engineering><Enzyme Gene><Enzymes><Equilibrium><Evaluation><Fibroblasts><Functional disorder><GJB2><GJB2 gene><Gap Junction Protein, 26-KD><Gap Junction Protein, Beta-2><Gene Delivery><Gene Targeting><Gene Transcription><Gene Transfer Clinical><Genes><Genetic><Genetic Change><Genetic Intervention><Genetic Transcription><Genetic defect><Genetic mutation><Goals><Guide RNA><Health><Hearing><Hearing Loss><Heterozygote><Histologic><Histologically><Human><Hypoacuses><Hypoacusis><In Vitro><Individual><Injections><Internal Ear><KI mice><Knock-in><Knock-in Mouse><Laboratories><Labyrinth><Mediating><Mesenchymal><Messenger RNA><Methods><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Mutation><NGS Method><NGS system><Non-sense Mediated Decay><Nonsense-Mediated Decay><Organism><Organoids><Pathogenicity><Pathology><Patients><Pediatric Hospitals><Phenotype><Physiopathology><Plasmids><Pluripotent Stem Cells><Population><Procedures><Proteins><Protocol><Protocols documentation><RNA Expression><Reagent><Research><Research Resources><Resources><Safety><Sensorineural Deafness><Sensorineural Hearing Loss><Sensory Hearing Loss><Severities><Site><Skin><Specificity><System><Temporal Bone><Temporal bone structure><Testing><Therapeutic><Therapeutic Intervention><Time><Tissue Sample><Tissues><Transcript><Transcription><Transfection><Treatment Efficacy><Variant><Variation><Vestibular><Vestibular System Impairment><Vestibular defect><Vestibular dysfunction><Vestibular problems><adulthood><ages><balance><balance disorder><balance function><balance impairment><biologic><cell type><cochlear window><cutaneous biopsy><cutaneous stem cells><deafness><dermal progenitor><dermal stem cell><design><design and construct><design and construction><design validation><design verification><designing><developmental><discover genes><disease model><disorder model><disturbed balance><dysfunctional hearing><early onset><equilibration disorder><equilibrium disorder><experiment><experimental research><experimental study><experiments><fenestra cochleae><gRNA><gain of function><gain of function mutation><gene corrected><gene correction><gene discovery><gene editing method><gene editing methodology><gene editing platform><gene editing strategy><gene editing system><gene editing techniques><gene editing technology><gene editing tools><gene repair therapy><gene therapy><gene-based therapy><gene-editing approach><gene-editing toolkit><genetic approach><genetic hearing impairment><genetic hearing loss><genetic strategy><genetic therapy><genome mutation><genomic correction><genomic therapy><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><hereditary hearing impairment><hereditary hearing loss><heterozygosity><iPS><iPSC><iPSCs><in vivo><indel><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inherited hearing impairment><inherited hearing loss><inner ear><inner ear development><innovate><innovation><innovative><insertion/deletion><insertion/deletion mutation><interest><intervention efficacy><intervention therapy><knockin><knockin mice><living system><mRNA><mRNA Expression><mouse model><murine model><mutant><new approaches><next gen sequencing><next generation sequencing><nextgen sequencing><novel approaches><novel strategies><novel strategy><nucleofection><pathophysiology><pluripotent progenitor><postnatal><preservation><prevent><preventing><progressive hearing loss><round window><safety assessment><sensorineural hearing impairment><skin biopsy><skin progenitor><skin stem cell><success><therapeutic efficacy><therapy efficacy><tool development><transduction efficiency><translational goal><translational mission><vector><vestibular deficit><vestibular impairment><vestibular system><vestibular system dysfunction>

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Sarah Anne Tishkoff

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$688,506

FY 2026

Project Title

Integrative Genomic Analyses of Human Evolution and Complex Traits in Africa

Grant Number:

1R35GM161902-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Africa is the site of origin of modern humans, contains the greatest levels of human genomic variation, and is the source of the worldwide range expansion of modern humans in the past 100,000 years. However, a fundamental gap in knowledge exists regarding African genomic and phenotypic variation, re...

Research Terms

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Julia C Carnevale

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$680,597

FY 2026

Project Title

Genome-Wide In Vivo CRISPR Screens in Human T Cells Identify GPCR Pathway Targets to Enhance CAR-T Therapies for Solid Tumors

Grant Number:

1R01CA309039-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Background: T cell therapies have been transformative for certain leukemias and lymphomas, however solid tumors have proven far more difficult due to challenges such as poor infiltration, harsh metabolic environments, and a myriad of suppressive factors in the tumor microenvironment (TME). Most larg...

Research Terms

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Eirini Papapetrou

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$677,959

FY 2026

Project Title

Mechanisms and targeting of aberrant Gas activation in myeloid neoplasms

Grant Number:

5R01CA271418-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Myelodysplastic syndromes (MDS) are myeloid neoplasms with dismal prognosis, frequent progression to acute myeloid leukemia (AML) and no effective treatment. A decade ago, a development with transformative potential for this disease was the discovery that more than half of ...

Research Terms

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Changchun Liu

UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, FARMINGTON, CT

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$643,849

FY 2026

Project Title

Asymmetric CRISPR Approach for Nucleic Acid Quantification

Grant Number:

2R01EB023607-06A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract The quantitative detection of nucleic acids plays an increasingly important role in the early detection and screening of cancers. Although the real-time quantitative PCR method has become the gold standard for nucleic acid quantification, its reliance on expensive equipment and trained pers...

Research Terms

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Kate E Keller

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Recent

Active award

$624,000

FY 2026

Project Title

Ophthalmology Core Facility

Grant Number:

5P30EY010572-32

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

5/1/1997

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

OVERALL CORE PROJECT SUMMARY This P30 Ophthalmology Core Facility provides ongoing support for NEI-funded Oregon Health and Science University (OHSU) and Casey Eye Institute vision researchers. The four resource cores are: Bioimaging & Confocal Microscopy; Gene Expression & Manipulation; Proteomics;...

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Jian Xu

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$614,231

FY 2026

Project Title

Dissecting Enhancer-Centric Mechanisms for Therapeutic Targeting of BCL11A

Grant Number:

2R01DK111430-11

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/19/2016

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The transcription factor BCL11A is a genetically and clinically validated regulator of the fetal-to-adult hemoglobin switch in human erythroid cells. BCL11A directly represses fetal hemoglobin (HbF) genes, and reactivation of HbF can alleviate the severity of β-hemoglobinopathies, su...

Research Terms

<21+ years old><3-D><3-Dimensional><3D><Ablation><Adult><Adult Human><Affect><Antisense Agent><Antisense Oligonucleotides><Architecture><Assay><B-thalassemia><BCL11A gene><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biological Assay><Blood Diseases><CD34><CD34 gene><CRISPR><CRISPR approach><CRISPR based approach><CRISPR based therapeutics><CRISPR based treatment><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR therapeutics><CRISPR tools><CRISPR treatment><CRISPR-CAS-9><CRISPR-Cas based therapeutics><CRISPR-based disease therapeutics><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based therapy><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas therapeutics><CRISPR/Cas9><CRISPR/Cas9 technology><CRISPR/Cas9 therapeutics><CRISPR/Cas9 therapy><CRISPR/Cas9 treatment><CRISPR/Cas9-based therapy><Cas nuclease technology><Cas9 based therapeutics><Cell Body><Cells><Chemicals><Chromatin><Chromatin Loop><Chromatin Loop Domains><Clinical><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats based therapeutics><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Clustered Regularly Interspaced Short Palindromic Repeats therapeutics><DNA Loop><DNA Therapy><DNA mutation><Data><Development><Disease><Disorder><Engineering / Architecture><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Erythroblasts><Erythroid><Erythroid Cells><Erythropoiesis><Fetal Hb><Fetal Hemoglobin><Funding><Gene Action Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Gene Transfer Clinical><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Change><Genetic Intervention><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Goals><HPCA1><HSC differentiation><Hb SS disease><HbAS><HbF><HbSS disease><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hemoglobin><Hemoglobin F><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hemoglobinopathies><Hereditary><Human><Inherited><Link><Maps><Mediating><Modern Man><Modification><Molecular><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Mutation><Non-Polyadenylated RNA><Normoblasts><Nucleated Erythrocytes><Nucleated red blood cell><Nucleated red cell><Outcome><Patients><Persons><Polycomb><Post-Transcriptional Gene Silencing><Production><RNA><RNA Expression><RNA Gene Products><RNA Interference><RNA Silencing><RNA and protein interaction><RNA-Protein Interaction><RNAi><Regulation><Regulatory approval><Repression><Ribonucleic Acid><Risk><Role><Sequence-Specific Posttranscriptional Gene Silencing><Severities><Sickle Cell Anemia><Sickle Cell Trait><Structure><Symptoms><Testing><Therapeutic><Transcription><Transcription Factor Proto-Oncogene><Transcription Initiation><Transcription factor genes><Treatment Efficacy><Validation><Work><adulthood><antisense oligo><base editing><beta Thalassemia><blood cell formation><blood disorder><burden of disease><burden of illness><clinical development><clinical validation><cohesin><conformation><conformational><conformational state><conformationally><conformations><cost><developmental><disease burden><epigenetic gene silencing><epigenetic silencing><epigenetically><erythroid development><fetal><fetal form of hemoglobin><fetal globin><gamma Globin><gene repair therapy><gene therapy><gene-based therapy><genetic association><genetic therapy><genome mutation><genomic therapy><hematopoietic progenitor cell differentiation><hematopoietic progenitor differentiation><hematopoietic stem cell differentiation><improved><insight><interdisciplinary approach><intervention efficacy><multidisciplinary approach><nucleated RBCs><p-Thalassemia><prevent><preventing><regulatory authorization><regulatory certification><regulatory clearance><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><single molecule><social role><success><therapeutic efficacy><therapeutic target><therapy efficacy><three dimensional><transcription factor><validations><β-thalassemia><γ-Globin>

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Isabelle M.A. Lombaert

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$601,942

FY 2026

Project Title

Epigenetic Therapy to Treat Radiation-induced Xerostomia

Grant Number:

5R01DE032014-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Most head-and-neck cancer patients receiving radiotherapy treatment develop life-long adverse effects. Side effects presented as hyposalivation and chronic xerostomia result from radiation damage to nearby salivary glands. Limited palliative options are currently available for these patien...

Research Terms

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KATHRYN M ROEDER

CARNEGIE-MELLON UNIVERSITY, PITTSBURGH, PA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$592,551

FY 2026

Project Title

Methods for single-cell CRISPR screens and multiomic data: constructing powerful well-calibrated tests, circumventing unmeasured confounding, and accounting for denoising and imputation

Grant Number:

5R01MH123184-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project summary/abstract In this application, we request continuation of MH123184, which aimed to understand how genetic variation alters transcription in specific cells and thereby produces psychopathology. Our research developed statistical methods to integrate single cell and tissue-level transcr...

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ROY H. Perlis

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$592,223

FY 2026

Project Title

Characterization of schizophrenia liability genes in models of human microglial synaptic pruning

Grant Number:

5R01MH131687-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/12/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Schizophrenia is a chronic, disabling, and strongly heritable illness. Existing treatments do not restore function for many patients, nor do they modify the disease process, and development of novel therapeutics is hindered by a lack of biological targets. Postmortem studies demonstrate reduced cort...

Research Terms

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Steven D Sheridan

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$592,223

FY 2026

Project Title

Characterization of schizophrenia liability genes in models of human microglial synaptic pruning

Grant Number:

5R01MH131687-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/12/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Schizophrenia is a chronic, disabling, and strongly heritable illness. Existing treatments do not restore function for many patients, nor do they modify the disease process, and development of novel therapeutics is hindered by a lack of biological targets. Postmortem studies demonstrate reduced cort...

Research Terms

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Angelique Bordey

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$583,646

FY 2026

Project Title

Cilia disassembly and dysfunction in malformations of cortical development

Grant Number:

1R01NS146115-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/20/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Malformations of cortical development (MCDs) are neurological disorders characterized by altered organization and function of cortical neurons, often leading to intractable epileptic seizures. Somatic mutations in more than 60 genes have been found in MCDs, with pathogenic variants c...

Research Terms

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David King Breslow

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$583,646

FY 2026

Project Title

Cilia disassembly and dysfunction in malformations of cortical development

Grant Number:

1R01NS146115-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/20/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Malformations of cortical development (MCDs) are neurological disorders characterized by altered organization and function of cortical neurons, often leading to intractable epileptic seizures. Somatic mutations in more than 60 genes have been found in MCDs, with pathogenic variants c...

Research Terms

View Full Project Details on NIH Reporter

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FARHAD R DANESH

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$565,025

FY 2026

Project Title

Regulation of Mitochondrial Respiration in Diabetic Kidney Disease

Grant Number:

5R01DK142664-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Current treatments of diabetic kidney disease (DKD) mainly focus on managing the symptoms of diabetes and do not address the root causes of DKD. Among causal mechanisms associated with the progression of DKD, there is growing recognition of the central role of mitochondrial dysfuncti...

Research Terms

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EKTA KHURANA

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$544,073

FY 2026

Project Title

Computational and experimental methods for scalable identification of oncogenic non-coding regions

Grant Number:

5R01CA218668-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2018

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Abstract In this project, we will identify context-specific enhancers, whose activity is essential for either the growth of primary tumors or for evolution of treatment-resistance in metastatic tumors by modulation of target gene expression. We will identify open chromatin sites in metastati...

Research Terms

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Neville Sanjana

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$544,073

FY 2026

Project Title

Computational and experimental methods for scalable identification of oncogenic non-coding regions

Grant Number:

5R01CA218668-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2018

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Abstract In this project, we will identify context-specific enhancers, whose activity is essential for either the growth of primary tumors or for evolution of treatment-resistance in metastatic tumors by modulation of target gene expression. We will identify open chromatin sites in metastati...

Research Terms

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MICHAEL S LAWRENCE

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$530,113

FY 2026

Project Title

Mechanisms of APOBEC3A-induced cancer evolution and cancer vulnerability

Grant Number:

5R01CA262874-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/9/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Cancer evolution driven by DNA-mutating APOBEC enzymes (apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like), and the emergence of resistance to therapy, present a pressing clinical challenge. In particular, the APOBEC3A (A3A) enzyme is implicated in a range of ...

Research Terms

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Dongwon Lee

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$506,574

FY 2026

Project Title

An ensemble framework for regulatory variant prediction.

Grant Number:

5R01HG012871-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/10/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Transcriptional cis-regulatory elements (CREs), such as enhancers and promoters, play an essential role in all biological processes by controlling the expression of their target genes. Sequence variants in these CREs can perturb their target gene expression by altering the binding of...

Research Terms

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JOSEPH CORBO

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$500,157

FY 2026

Project Title

Targeting Nr2e3 to prevent photoreceptor degeneration

Grant Number:

5R01EY033810-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/28/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Retinitis pigmentosa (RP) is the most common form of retinal dystrophy and can be caused by mutations in any one of dozens of rod-enriched genes. The genetic heterogeneity of RP represents a major challenge for the development of effective therapies. For this reason, gene-independent...

Research Terms

<21+ years old><Acute><Adeno-Associated Viruses><Adult><Adult Human><Adverse effects><Affect><Animal Disease Models><Animal Model><Animal Models and Related Studies><Assay><Basal Transcription Factor><Basal transcription factor genes><Behavioral><Behavioral Assay><Bioassay><Biological Assay><Blindness><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Candidate Disease Gene><Candidate Gene><Cas nuclease technology><Cell Body><Cell Reprogramming><Cells><Cessation of life><Clinical Research><Clinical Study><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cone><DNA mutation><Data><Death><Dependoparvovirus><Dependovirus><Development><Disabling><Disease><Disease Progression><Disorder><Dysfunction><Electron Microscopy><Electrophysiology><Electrophysiology (science)><Functional disorder><Future><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Change><Genetic Heterogeneity><Genetic defect><Genetic mutation><Goals><Histologic><Histologically><Human><Hybrid Cells><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Knock-out><Knockout><Light><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Morbidity><Morphology><Motivation><Murine><Mus><Mutation><Neurophysiology / Electrophysiology><Patients><Persons><Photoradiation><Photoreceptor Cell><Photoreceptors><Photosensitive Cell><Physiologic><Physiological><Physiopathology><Pigmentary Retinopathy><RNA Seq><RNA sequencing><RNAseq><Retinal Degeneration><Retinal Dystrophy><Retinitis Pigmentosa><Rod><Rod Photoreceptors><Sight><Somatic Cell Hybrids><Source><Structure><Tapetoretinal Degeneration><Testing><Therapeutic><Transcript Expression Analyses><Transcript Expression Analysis><Transcription Factor Proto-Oncogene><Transcription factor genes><Treatment Efficacy><Vision><Vision research><Visual Receptor><Wild Type Mouse><Work><adeno associated virus group><adulthood><analyze gene expression><behavior phenotype><behavioral phenotyping><candidate selection><cell type><cellular reprogramming><degenerative retina diseases><determine efficacy><developmental><disease model><disorder model><effective therapy><effective treatment><effectiveness testing><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electrophysiological><evaluate efficacy><examine efficacy><gene expression analysis><gene expression assay><genome mutation><inherited retinal degeneration><intervention efficacy><model of animal><mouse model><murine model><neuroprotection><neuroprotective><new approaches><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel approaches><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><overexpress><overexpression><pathophysiology><photoreceptor degeneration><preservation><prevent><preventing><retina degeneration><retinal degenerative><retinal degenerative diseases><retinal rods><rho><rod and cone dystrophy><rod cell><rod-cone dystrophy><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy><transcription factor><transcriptional profiling><transcriptome sequencing><transcriptomic sequencing><vision loss><visual function><visual loss><wildtype mouse>

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Vladimir Jivkov Kefalov

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$500,157

FY 2026

Project Title

Targeting Nr2e3 to prevent photoreceptor degeneration

Grant Number:

5R01EY033810-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/28/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Retinitis pigmentosa (RP) is the most common form of retinal dystrophy and can be caused by mutations in any one of dozens of rod-enriched genes. The genetic heterogeneity of RP represents a major challenge for the development of effective therapies. For this reason, gene-independent...

Research Terms

<21+ years old><Acute><Adeno-Associated Viruses><Adult><Adult Human><Adverse effects><Affect><Animal Disease Models><Animal Model><Animal Models and Related Studies><Assay><Basal Transcription Factor><Basal transcription factor genes><Behavioral><Behavioral Assay><Bioassay><Biological Assay><Blindness><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Candidate Disease Gene><Candidate Gene><Cas nuclease technology><Cell Body><Cell Reprogramming><Cells><Cessation of life><Clinical Research><Clinical Study><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cone><DNA mutation><Data><Death><Dependoparvovirus><Dependovirus><Development><Disabling><Disease><Disease Progression><Disorder><Dysfunction><Electron Microscopy><Electrophysiology><Electrophysiology (science)><Functional disorder><Future><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Change><Genetic Heterogeneity><Genetic defect><Genetic mutation><Goals><Histologic><Histologically><Human><Hybrid Cells><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Knock-out><Knockout><Light><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Morbidity><Morphology><Motivation><Murine><Mus><Mutation><Neurophysiology / Electrophysiology><Patients><Persons><Photoradiation><Photoreceptor Cell><Photoreceptors><Photosensitive Cell><Physiologic><Physiological><Physiopathology><Pigmentary Retinopathy><RNA Seq><RNA sequencing><RNAseq><Retinal Degeneration><Retinal Dystrophy><Retinitis Pigmentosa><Rod><Rod Photoreceptors><Sight><Somatic Cell Hybrids><Source><Structure><Tapetoretinal Degeneration><Testing><Therapeutic><Transcript Expression Analyses><Transcript Expression Analysis><Transcription Factor Proto-Oncogene><Transcription factor genes><Treatment Efficacy><Vision><Vision research><Visual Receptor><Wild Type Mouse><Work><adeno associated virus group><adulthood><analyze gene expression><behavior phenotype><behavioral phenotyping><candidate selection><cell type><cellular reprogramming><degenerative retina diseases><determine efficacy><developmental><disease model><disorder model><effective therapy><effective treatment><effectiveness testing><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electrophysiological><evaluate efficacy><examine efficacy><gene expression analysis><gene expression assay><genome mutation><inherited retinal degeneration><intervention efficacy><model of animal><mouse model><murine model><neuroprotection><neuroprotective><new approaches><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel approaches><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><overexpress><overexpression><pathophysiology><photoreceptor degeneration><preservation><prevent><preventing><retina degeneration><retinal degenerative><retinal degenerative diseases><retinal rods><rho><rod and cone dystrophy><rod cell><rod-cone dystrophy><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy><transcription factor><transcriptional profiling><transcriptome sequencing><transcriptomic sequencing><vision loss><visual function><visual loss><wildtype mouse>

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Thomas L. Kash

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

High-opportunity lead · 74/100

Likely hiring

Solid budget

Very recent

Active award

$448,712

FY 2026

Project Title

5/8 INIA Stress and Chronic Alcohol Interactions: Probing brain circuits that regulate alcohol stress interactions

Grant Number:

5U01AA020911-15

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/10/2012

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary In this project we will mechanistically explore two neuromodulatory systems within the extended amydala and how they regulate plasticity and behavior following alcohol exposure and stress. In particular, in aims 1 and 2 we will utilize novel CRISPR technology to manipulate signaling ...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><Address><Adrenergic Receptor><Adrenoceptors><Affect><Affective><Agonist><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohol dependence><Alcohols><Aminalon><Aminalone><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anabolism><Anatomic Sites><Anatomic structures><Anatomy><Area><Bed Nucleus of Stria Terminalis><Behavior><Behavior assessment><Biosensor><Brain><Brain Nervous System><Brain imaging><Brain region><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Communication and Signaling><Cell Signaling><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Consumption><Coping Behavior><Coupled><Differences between sexes><Differs between sexes><Disease><Disorder><Dopamine><Dynorphins><Electrophysiology><Electrophysiology (science)><Encephalon><Epinephrine Receptors><EtOH drinking><EtOH use><Evaluation><Exposure to><Female><Fiber><Functional MRI><Functional Magnetic Resonance Imaging><Funding><GABA><Glutamates><Goals><Grant><Heavy Drinking><Hydroxytyramine><Individual><Intracellular Communication and Signaling><Investigation><Knock-out><Knockout><L-Glutamate><Lab Findings><Laboratory Finding><Levarterenol><Levonorepinephrine><Mice><Mice Mammals><Modality><Modeling><Molecular><Murine><Mus><NE system><Nerve Cells><Nerve Unit><Network Analysis><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Noradrenaline><Norepinephrine><Outcome><Outcome Measure><Output><Pathway Analysis><Persons><Photometry><Physiology><Play><Prevalence><Property><R-Series Research Projects><R01 Mechanism><R01 Program><Receptor Signaling><Regulation><Research Grants><Research Project Grants><Research Projects><Role><Sex Differences><Sexual differences><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Stress><Stress and Coping><Stria Terminalis Nucleus><Structure><Structure of terminal stria nuclei of preoptic region><System><Testing><United States><Ventral Tegmental Area><Withdrawal><Work><activity marker><adenoreceptor><alcohol addiction><alcohol dependency><alcohol dependent><alcohol exposed><alcohol exposure><alcohol ingestion><alcohol intake><alcohol product use><alcohol response><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><amygdaloid nuclear complex><anxiety-like behavior><behavioral assessment><biological sensor><biological signal transduction><biosynthesis><brain visualization><coping with stress><drink heavily><electrophysiological><ethanol consumption><ethanol drinking><ethanol exposed><ethanol exposure><ethanol ingestion><ethanol intake><ethanol product use><ethanol response><ethanol use><ethanol use disorder><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><exposed to alcohol><exposed to ethanol><exposure to alcohol><exposure to ethanol><extreme drinking><fMRI><gamma-Aminobutyric Acid><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><glutamatergic><heavy alcohol use><in vivo><individual heterogeneity><individual variability><individual variation><insight><kappa opiate><kappa opioid><kappa opioid receptors><male><measurable outcome><multidrug abuse><multiple drug abuse><negative affect><negative affectivity><neural control><neural regulation><neurobiological mechanism><neuromodulation><neuromodulatory><neuronal><neuroregulation><non-human primate><nonhuman primate><noradrenergic><norepinephrine system><novel><outcome measurement><pharmacologic><polydrug abuse><response><response to alcohol><response to ethanol><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><stress-related coping><ventral tegmentum><γ-Aminobutyric Acid><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR><♀><♂>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Zoe Anastasia McElligott

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

High-opportunity lead · 74/100

Likely hiring

Solid budget

Very recent

Active award

$448,712

FY 2026

Project Title

5/8 INIA Stress and Chronic Alcohol Interactions: Probing brain circuits that regulate alcohol stress interactions

Grant Number:

5U01AA020911-15

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/10/2012

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary In this project we will mechanistically explore two neuromodulatory systems within the extended amydala and how they regulate plasticity and behavior following alcohol exposure and stress. In particular, in aims 1 and 2 we will utilize novel CRISPR technology to manipulate signaling ...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><Address><Adrenergic Receptor><Adrenoceptors><Affect><Affective><Agonist><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohol dependence><Alcohols><Aminalon><Aminalone><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anabolism><Anatomic Sites><Anatomic structures><Anatomy><Area><Bed Nucleus of Stria Terminalis><Behavior><Behavior assessment><Biosensor><Brain><Brain Nervous System><Brain imaging><Brain region><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Communication and Signaling><Cell Signaling><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Consumption><Coping Behavior><Coupled><Differences between sexes><Differs between sexes><Disease><Disorder><Dopamine><Dynorphins><Electrophysiology><Electrophysiology (science)><Encephalon><Epinephrine Receptors><EtOH drinking><EtOH use><Evaluation><Exposure to><Female><Fiber><Functional MRI><Functional Magnetic Resonance Imaging><Funding><GABA><Glutamates><Goals><Grant><Heavy Drinking><Hydroxytyramine><Individual><Intracellular Communication and Signaling><Investigation><Knock-out><Knockout><L-Glutamate><Lab Findings><Laboratory Finding><Levarterenol><Levonorepinephrine><Mice><Mice Mammals><Modality><Modeling><Molecular><Murine><Mus><NE system><Nerve Cells><Nerve Unit><Network Analysis><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Noradrenaline><Norepinephrine><Outcome><Outcome Measure><Output><Pathway Analysis><Persons><Photometry><Physiology><Play><Prevalence><Property><R-Series Research Projects><R01 Mechanism><R01 Program><Receptor Signaling><Regulation><Research Grants><Research Project Grants><Research Projects><Role><Sex Differences><Sexual differences><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Stress><Stress and Coping><Stria Terminalis Nucleus><Structure><Structure of terminal stria nuclei of preoptic region><System><Testing><United States><Ventral Tegmental Area><Withdrawal><Work><activity marker><adenoreceptor><alcohol addiction><alcohol dependency><alcohol dependent><alcohol exposed><alcohol exposure><alcohol ingestion><alcohol intake><alcohol product use><alcohol response><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><amygdaloid nuclear complex><anxiety-like behavior><behavioral assessment><biological sensor><biological signal transduction><biosynthesis><brain visualization><coping with stress><drink heavily><electrophysiological><ethanol consumption><ethanol drinking><ethanol exposed><ethanol exposure><ethanol ingestion><ethanol intake><ethanol product use><ethanol response><ethanol use><ethanol use disorder><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><exposed to alcohol><exposed to ethanol><exposure to alcohol><exposure to ethanol><extreme drinking><fMRI><gamma-Aminobutyric Acid><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><glutamatergic><heavy alcohol use><in vivo><individual heterogeneity><individual variability><individual variation><insight><kappa opiate><kappa opioid><kappa opioid receptors><male><measurable outcome><multidrug abuse><multiple drug abuse><negative affect><negative affectivity><neural control><neural regulation><neurobiological mechanism><neuromodulation><neuromodulatory><neuronal><neuroregulation><non-human primate><nonhuman primate><noradrenergic><norepinephrine system><novel><outcome measurement><pharmacologic><polydrug abuse><response><response to alcohol><response to ethanol><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><stress-related coping><ventral tegmentum><γ-Aminobutyric Acid><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR><♀><♂>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Paul J. Kenny

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$2,350,996

FY 2026

Project Title

Mining SCORCH transcriptomics data to resolve functionally relevant striatal cell types

Grant Number:

1R01DA065101-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY This application is submitted in response to RFA-DA-26-001: SCORCH Data Mining and Functional Validation. Human immunodeficiency virus (HIV) infects non-neuronal cells in the brain, particularly microglia, which serve as reservoirs of latent infection. HIV has deleterious effects on ...

Research Terms

<2-dimensional><3-D><3-Dimensional><3D><AIDS Virus><Abstinence><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Affective><Architecture><Archives><Atlases><Axon><Behavior><Behavioral><Behavioral Assay><Brain><Brain Nervous System><Brain region><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Classification><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cognition><Cognitive><Common Rat Strains><Corpus Striatum><Corpus striatum structure><D2 receptor><DRD2 Receptor><Data><Data Set><Dihydrohydroxycodeinone><Dopamine D2 Receptor><Drugs><Electrophysiology><Electrophysiology (science)><Emotions><Encephalon><Engineering / Architecture><Exhibits><Gene Transcription><General Population><General Public><Genes><Genetic><Genetic Transcription><Genomics><Glia><Glial Cells><Goals><HIV><HIV Infections><HIV individuals><HIV infected individuals><HIV infected persons><HIV latency><HIV people><HIV positive individuals><HIV positive people><HIV viral infection><HIV virus infection><HIV-1 infection><History><Hortega cell><Human><Human Immunodeficiency Viruses><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Intravenous><Investigation><Kolliker's reticulum><LAV-HTLV-III><Lymphadenopathy-Associated Virus><MAPseq><Macrophage><Maps><Mediating><Medication><Mice><Mice Mammals><Microglia><Mining><Modern Man><Molecular><Motivation><Multiplexed Analysis of Projections by Sequencing><Murine><Mus><Mφ><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Non-neuronal cell><Nonneuronal cell><Nucleus Accumbens><Opiate replacement therapy><Opiate substitution therapy><Opiate substitution treatment><Opiates><Opioid><Opioid maintenance therapy><Opioid maintenance treatment><Opioid replacement therapy><Opioid replacement treatment><Opioid substitution therapy><Opioid substitution treatment><Output><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><PLWH><PWH><Pharmaceutical Preparations><Phenotype><Population><Property><Public Health><RNA Expression><Rat><Rats Mammals><Rattus><Recording of previous events><Research><Resolution><Rewards><Risk><Risk Factors><Role><Roxicodone><Self Administered><Self Administration><Severities><Single-Nucleus Sequencing><Spatial Distribution><Specificity><Striate Body><Striatum><Subcellular Process><Synapses><Synaptic><System><Systematics><T4 Cells><T4 Lymphocytes><Testing><Transcription><Validation><Virus-HIV><abused drug><abused drugs><antiretroviral therapy><antiretroviral treatment><asymptomatic HIV infection><cell type><chronic HIV infection><co-morbid><co-morbidity><comorbidity><data mining><datamining><differential expression><differentially expressed><drug abused><drug of abuse><drug/agent><drugs abused><drugs of abuse><electrophysiological><experience><functional adaptation><gitter cell><histories><human immunodeficiency virus infection><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><innovate><innovation><innovative><intravenous opiate><intravenous opioid><latent HIV infection><latent infection><mesoglia><microglial cell><microgliocyte><multiomics><multiple omics><nerve cement><neural circuit><neural circuitry><neural mechanism><neurocircuitry><neuromechanism><neuronal><non-human primate><non-medical opioid use><nonhuman primate><nonmedical opioid use><novel><opiate consumption><opiate deaths><opiate drug use><opiate exposure><opiate injection><opiate intake><opiate misuse><opiate mortality><opiate use><opiate use disorder><opioid consumption><opioid deaths><opioid drug use><opioid exposure><opioid injection><opioid injector><opioid intake><opioid misuse><opioid mortality><opioid overdose death><opioid related death><opioid use><opioid use disorder><panomics><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><perivascular glial cell><population based><programs><resolutions><response><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><striatal><synapse><synaptic circuit><synaptic circuitry><three dimensional><transcriptional differences><transcriptomics><two-dimensional><validations>

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Molly OhAinle

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$2,057,334

FY 2026

Project Title

Lentiviral Restriction: capsid and beyond

Grant Number:

2R01AI147877-08A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/14/2019

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

HIV-1 infection of humans is a recently acquired cross-species infection from related primates. In contrast to recent human infection, the HIV-related primate lentiviruses have infected and co- evolved with their primate hosts for millions of years. Understanding how host cells allow for or restrict...

Research Terms

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Christina A Cuomo

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,233,501

FY 2026

Project Title

Mapping the genomic and molecular mechanisms of antifungal resistance in the emerging fungal pathogen Candida auris

Grant Number:

5R01AI169066-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/6/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT Candida auris is an emerging multidrug-resistant fungal pathogen of great clinical concern that is associated with outbreaks on six continents. A critical barrier to overcoming the high antifungal resistance in C. auris is the significant lack of understanding of its genetic...

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P. David Rogers

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,233,501

FY 2026

Project Title

Mapping the genomic and molecular mechanisms of antifungal resistance in the emerging fungal pathogen Candida auris

Grant Number:

5R01AI169066-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/6/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT Candida auris is an emerging multidrug-resistant fungal pathogen of great clinical concern that is associated with outbreaks on six continents. A critical barrier to overcoming the high antifungal resistance in C. auris is the significant lack of understanding of its genetic...

Research Terms

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Thomas Gaj

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Good lead · 68/100

Likely hiring

Above-average budget

Active award

Team-scale grant

$859,980

FY 2026

Project Title

Optimization of an in vivo base editing strategy to treat SOD1-linked ALS

Grant Number:

5U01NS122102-05

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/23/2021

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, paralytic and ultimately fatal disease characterized by the selective loss of motor neurons in the spinal cord and brain. The overarching objective of this application to the Optimization Track of the CREATE Bio Program is...

Research Terms

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Pablo Perez-Pinera

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Good lead · 68/100

Likely hiring

Above-average budget

Active award

Team-scale grant

$859,980

FY 2026

Project Title

Optimization of an in vivo base editing strategy to treat SOD1-linked ALS

Grant Number:

5U01NS122102-05

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/23/2021

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, paralytic and ultimately fatal disease characterized by the selective loss of motor neurons in the spinal cord and brain. The overarching objective of this application to the Optimization Track of the CREATE Bio Program is...

Research Terms

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David Terry Curiel

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Large award

Active award

$1,394,808

FY 2026

Project Title

Vectored HIV Immunotherapy via in vivo B cell editing

Grant Number:

5R01AI174270-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT A variety of gene therapy strategies have been developed to achieve HIV cure. These strategies include genetic methods to render immune cells resistant to infection or to enhance immune effector cell anti-HIV activity. In this latter instance, genetic engineering of B cells has provided a h...

Research Terms

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Michael R. Farzan

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Large award

Active award

$1,394,808

FY 2026

Project Title

Vectored HIV Immunotherapy via in vivo B cell editing

Grant Number:

5R01AI174270-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT A variety of gene therapy strategies have been developed to achieve HIV cure. These strategies include genetic methods to render immune cells resistant to infection or to enhance immune effector cell anti-HIV activity. In this latter instance, genetic engineering of B cells has provided a h...

Research Terms

View Full Project Details on NIH Reporter

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Mauricio A Martins

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Large award

Active award

$1,394,808

FY 2026

Project Title

Vectored HIV Immunotherapy via in vivo B cell editing

Grant Number:

5R01AI174270-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT A variety of gene therapy strategies have been developed to achieve HIV cure. These strategies include genetic methods to render immune cells resistant to infection or to enhance immune effector cell anti-HIV activity. In this latter instance, genetic engineering of B cells has provided a h...

Research Terms

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MICHAEL P CZECH

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$823,098

FY 2026

Project Title

CRISPR-enhanced adipocyte browning to improve glucose tolerance in obesity and diabetes

Grant Number:

2R01DK130852-05A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/17/2021

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract The long term goal of this project is to understand the mechanisms by which human “beige” adipocytes improve metabolic health. We leverage CRISPR-based technology that enables human white adipocytes to maintain a maximally “beige” thermogenic phenotype. These CRISPR-modified cells greatly e...

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David Martin McCandlish

PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$806,828

FY 2026

Project Title

Evolutionary and drug resistance landscape of human tyrosine kinases

Grant Number:

1R01HG013692-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/16/2026

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Tyrosine kinases cause Mendelian disorders, cancer, contribute to polygenic risk scores in common diseases, and have led to 62 approved drugs for cancer, inflammatory disorders, and lung fibrosis. However, the function of every kinase domain residue across the large number of existin...

Research Terms

<ATP-protein phosphotransferase><Affect><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Assay><Beds><Benchmarking><Best Practice Analysis><Bioassay><Biological Assay><Biophysics><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Drug><Cancers><Cas nuclease technology><Cell Line><CellLine><Cellular Expansion><Cellular Growth><Characteristics><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Coupled><DNA mutation><Data><Data Set><Disease><Disorder><Drug resistance><Drugs><EPH- and ELK-Related Tyrosine Kinase><EPH-and ELK-Related Kinase><Ephrin Type-A Receptor 8><Ephrin Type-A Receptor 8 Precursor><Epistasis><Epistatic Deviation><Evolution><Family><Family Research><Family member><Foundations><Gene Family><Generalized Growth><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Epistasis><Genetic Variation><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genome><Genomics><Genotype><Germ-Line Mutation><Goals><Growth><Hereditary Disease><Hereditary Mutation><Homologous Protein><Human><Hybrids><Inborn Genetic Diseases><Inflammatory><Inherited disorder><Interaction Deviation><Joints><Kinase Family Gene><Kinases><Knowledge><Language><Lung Tissue Fibrosis><Malignant Neoplasms><Malignant Tumor><Maps><Measurement><Measures><Medical><Medication><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Methods><Modeling><Modern Man><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Neoplastic Disease Chemotherapeutic Agents><PTK Inhibitors><Pattern><Pharmaceutical Preparations><Phenotype><Phosphotransferase Gene><Phosphotransferases><Phylogenetic Analysis><Phylogenetics><Point Mutation><Population Genetics><Position><Positioning Attribute><Process><Protein Family><Protein Homolog><Protein Kinase><Protein Region><Protein Tyrosine Kinase><Protein Tyrosine Kinase EEK><Protein Tyrosine Kinase Inhibitors><ProteinHomolog><Proteins><Pulmonary Fibrosis><Role><Sequence Alignment><Site><Somatic Mutation><Strains Cell Lines><Structure><TK Inhibitors><Techniques><Testing><Time><Tissue Growth><Transphosphorylases><Tumor-Specific Treatment Agents><Tyrosine Kinase><Tyrosine Kinase Inhibitor><Tyrosine-Protein Kinase Receptor EEK><Tyrosine-Specific Protein Kinase><Tyrosylprotein Kinase><Variant><Variation><Work><Xenobiotics><anti-cancer drug><base><base editing><base editor><bases><benchmark><biophysical foundation><biophysical principles><biophysical sciences><cell growth><cultured cell line><drug efficacy><drug resistant><drug safety><drug/agent><epistatic interaction><epistatic relationship><experiment><experimental research><experimental study><experiments><family based research><family centered research><family focused research><family investigation><fibrosis in the lung><fitness><gene x gene interaction><genetic epistases><genome mutation><genome scale><genome-wide><genomewide><germ-line defect><germline variant><glycogen synthase a kinase><hereditary disorder><heritable disorder><human disease><hydroxyalkyl protein kinase><hydroxyaryl protein kinase><inborn error><inherited diseases><inherited genetic disease><inherited genetic disorder><investigate family><lung fibrosis><malignancy><medication safety><monogenic disease><monogenic disorder><mutation scanning><mutation screening><neoplasm/cancer><ontogeny><pharmaceutical safety><phosphorylase b kinase kinase><polygenetic risk scores><polygenic risk score><reconstruction><reference assembly><reference genome><resistance to Drug><resistant to Drug><scale up><segregation><sequencing alignment><single-gene disease><single-gene disorder><social role><somatic variant><study family><survey family><tool><tyrosyl protein kinase>

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Justin Pritchard

PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$806,828

FY 2026

Project Title

Evolutionary and drug resistance landscape of human tyrosine kinases

Grant Number:

1R01HG013692-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/16/2026

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Tyrosine kinases cause Mendelian disorders, cancer, contribute to polygenic risk scores in common diseases, and have led to 62 approved drugs for cancer, inflammatory disorders, and lung fibrosis. However, the function of every kinase domain residue across the large number of existin...

Research Terms

<ATP-protein phosphotransferase><Affect><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Assay><Beds><Benchmarking><Best Practice Analysis><Bioassay><Biological Assay><Biophysics><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Drug><Cancers><Cas nuclease technology><Cell Line><CellLine><Cellular Expansion><Cellular Growth><Characteristics><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Coupled><DNA mutation><Data><Data Set><Disease><Disorder><Drug resistance><Drugs><EPH- and ELK-Related Tyrosine Kinase><EPH-and ELK-Related Kinase><Ephrin Type-A Receptor 8><Ephrin Type-A Receptor 8 Precursor><Epistasis><Epistatic Deviation><Evolution><Family><Family Research><Family member><Foundations><Gene Family><Generalized Growth><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Epistasis><Genetic Variation><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genome><Genomics><Genotype><Germ-Line Mutation><Goals><Growth><Hereditary Disease><Hereditary Mutation><Homologous Protein><Human><Hybrids><Inborn Genetic Diseases><Inflammatory><Inherited disorder><Interaction Deviation><Joints><Kinase Family Gene><Kinases><Knowledge><Language><Lung Tissue Fibrosis><Malignant Neoplasms><Malignant Tumor><Maps><Measurement><Measures><Medical><Medication><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Methods><Modeling><Modern Man><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Neoplastic Disease Chemotherapeutic Agents><PTK Inhibitors><Pattern><Pharmaceutical Preparations><Phenotype><Phosphotransferase Gene><Phosphotransferases><Phylogenetic Analysis><Phylogenetics><Point Mutation><Population Genetics><Position><Positioning Attribute><Process><Protein Family><Protein Homolog><Protein Kinase><Protein Region><Protein Tyrosine Kinase><Protein Tyrosine Kinase EEK><Protein Tyrosine Kinase Inhibitors><ProteinHomolog><Proteins><Pulmonary Fibrosis><Role><Sequence Alignment><Site><Somatic Mutation><Strains Cell Lines><Structure><TK Inhibitors><Techniques><Testing><Time><Tissue Growth><Transphosphorylases><Tumor-Specific Treatment Agents><Tyrosine Kinase><Tyrosine Kinase Inhibitor><Tyrosine-Protein Kinase Receptor EEK><Tyrosine-Specific Protein Kinase><Tyrosylprotein Kinase><Variant><Variation><Work><Xenobiotics><anti-cancer drug><base><base editing><base editor><bases><benchmark><biophysical foundation><biophysical principles><biophysical sciences><cell growth><cultured cell line><drug efficacy><drug resistant><drug safety><drug/agent><epistatic interaction><epistatic relationship><experiment><experimental research><experimental study><experiments><family based research><family centered research><family focused research><family investigation><fibrosis in the lung><fitness><gene x gene interaction><genetic epistases><genome mutation><genome scale><genome-wide><genomewide><germ-line defect><germline variant><glycogen synthase a kinase><hereditary disorder><heritable disorder><human disease><hydroxyalkyl protein kinase><hydroxyaryl protein kinase><inborn error><inherited diseases><inherited genetic disease><inherited genetic disorder><investigate family><lung fibrosis><malignancy><medication safety><monogenic disease><monogenic disorder><mutation scanning><mutation screening><neoplasm/cancer><ontogeny><pharmaceutical safety><phosphorylase b kinase kinase><polygenetic risk scores><polygenic risk score><reconstruction><reference assembly><reference genome><resistance to Drug><resistant to Drug><scale up><segregation><sequencing alignment><single-gene disease><single-gene disorder><social role><somatic variant><study family><survey family><tool><tyrosyl protein kinase>

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MICHAEL H. CHO

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$786,047

FY 2026

Project Title

Uncovering the genetically-driven differential susceptibility to chronic obstructive pulmonary disease and pulmonary fibrosis

Grant Number:

5R01HL162813-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Chronic obstructive pulmonary disease (COPD) and idiopathic pulmonary fibrosis (IPF) are two devastating chronic lung diseases associated with aging and with a common environmental risk factor, cigarette smoking, but with differing physiology and pathology, which may be due to genetics. Our...

Research Terms

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Zach N. Adelman

TEXAS A&M AGRILIFE RESEARCH, College Station, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$749,703

FY 2026

Project Title

Self-Eliminating Strategy To Control Gene Drive

Grant Number:

2R01AI148787-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/25/2020

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The ability to deliver pathogen-resistance genes into mosquito populations has long been sought as a potential alternative for disrupting dengue or malaria transmission where funds and infrastructure are the limiting factors in effective mosquito control. While effective gene drive transgenes based ...

Research Terms

<A. aegypti><Abscission><Acceleration><Ades aegypti><Ae. Aegypti><Aedes aegypti><Affect><Anopheles><Anopheles Genus><Anophelines><Arboviral><Arboviruses><Arthropod-Borne Viruses><Biologic Models><Biological><Biological Models><CHIKV><CHIKV fever><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Chikungunya fever><Chikungunya virus><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Culicidae><DNA Damage Repair><DNA Nicking Enzyme><DNA Recombination><DNA Repair><DNA Repair Gene><DNA Repair Pathway><DNA analysis><DNA repair protein><Dengue><Dengue Fever><Dengue disease><Development><Disease Vectors><Drosophila><Drosophila genus><Drosophila melanogaster><Endonuclease I><Engineering><Eukaryota><Eukaryote><Excision><Extirpation><Flies><Funding><Future><Generations><Genes><Genetic><Genetic Recombination><Genome><Genome engineering><Goals><Guide RNA><Homing><I-SceI><Infrastructure><International><Knowledge><Mediating><Medical><Meiotic Recombination><Methods><Model System><Mosquito Control><Mosquito-borne disease><Mosquito-borne infectious disease><Mosquitoes><Nickase><Outcome><Performance><Population><Process><Proteins><Recombination><Removal><Research><Resistance><Role><Safety><SceI endonuclease><Structure><Surgical Removal><System><Technology><Testing><Transgenes><Transgenic Organisms><Unscheduled DNA Synthesis><Work><Yellow Fever><ZIKV fever><Zika virus fever><analyze DNA><biologic><breakbone fever><chromosomal location><chromosomal position><chromosome location><communicable disease transmission><developmental><disease control><disease transmission><disorder control><endo.SceI><endodeoxyribonuclease Sce I><endodeoxyribonuclease SceI><endonuclease><expectation><experiment><experimental research><experimental study><experiments><fly><fruit fly><gRNA><gene drive approach><gene drive strategy><gene drive system><gene drive technology><gene locus><genetic locus><genome analysis><genomic location><genomic locus><global health><high throughput technology><homing driver><homing gene drive><improved><infectious disease transmission><innovate><innovation><innovative><malaria mosquito><malaria transmission><meganuclease I-SceI><model organism><next-generation gene drive><novel><nuclease><pathogen><recruit><repair><repaired><resection><resistance gene><resistance locus><resistant><resistant gene><response><social role><tool><trait><transgene><transgenic><vector><vector control><vector mosquito><zika fever>

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KEVIN M MYLES

TEXAS A&M AGRILIFE RESEARCH, College Station, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$749,703

FY 2026

Project Title

Self-Eliminating Strategy To Control Gene Drive

Grant Number:

2R01AI148787-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/25/2020

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The ability to deliver pathogen-resistance genes into mosquito populations has long been sought as a potential alternative for disrupting dengue or malaria transmission where funds and infrastructure are the limiting factors in effective mosquito control. While effective gene drive transgenes based ...

Research Terms

<A. aegypti><Abscission><Acceleration><Ades aegypti><Ae. Aegypti><Aedes aegypti><Affect><Anopheles><Anopheles Genus><Anophelines><Arboviral><Arboviruses><Arthropod-Borne Viruses><Biologic Models><Biological><Biological Models><CHIKV><CHIKV fever><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Chikungunya fever><Chikungunya virus><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Culicidae><DNA Damage Repair><DNA Nicking Enzyme><DNA Recombination><DNA Repair><DNA Repair Gene><DNA Repair Pathway><DNA analysis><DNA repair protein><Dengue><Dengue Fever><Dengue disease><Development><Disease Vectors><Drosophila><Drosophila genus><Drosophila melanogaster><Endonuclease I><Engineering><Eukaryota><Eukaryote><Excision><Extirpation><Flies><Funding><Future><Generations><Genes><Genetic><Genetic Recombination><Genome><Genome engineering><Goals><Guide RNA><Homing><I-SceI><Infrastructure><International><Knowledge><Mediating><Medical><Meiotic Recombination><Methods><Model System><Mosquito Control><Mosquito-borne disease><Mosquito-borne infectious disease><Mosquitoes><Nickase><Outcome><Performance><Population><Process><Proteins><Recombination><Removal><Research><Resistance><Role><Safety><SceI endonuclease><Structure><Surgical Removal><System><Technology><Testing><Transgenes><Transgenic Organisms><Unscheduled DNA Synthesis><Work><Yellow Fever><ZIKV fever><Zika virus fever><analyze DNA><biologic><breakbone fever><chromosomal location><chromosomal position><chromosome location><communicable disease transmission><developmental><disease control><disease transmission><disorder control><endo.SceI><endodeoxyribonuclease Sce I><endodeoxyribonuclease SceI><endonuclease><expectation><experiment><experimental research><experimental study><experiments><fly><fruit fly><gRNA><gene drive approach><gene drive strategy><gene drive system><gene drive technology><gene locus><genetic locus><genome analysis><genomic location><genomic locus><global health><high throughput technology><homing driver><homing gene drive><improved><infectious disease transmission><innovate><innovation><innovative><malaria mosquito><malaria transmission><meganuclease I-SceI><model organism><next-generation gene drive><novel><nuclease><pathogen><recruit><repair><repaired><resection><resistance gene><resistance locus><resistant><resistant gene><response><social role><tool><trait><transgene><transgenic><vector><vector control><vector mosquito><zika fever>

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Rami Khoriaty

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$744,722

FY 2026

Project Title

The molecular pathophysiology of the congenital dyserythropoietic anemias

Grant Number:

5R01HL148333-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2019

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Anemia due to defects in erythropoiesis (red blood cell production) is a major source of mortality and morbidity worldwide. The Congenital Dyserythropoietic Anemias (CDAs) are a group of disorders of terminal erythroid maturation defects characterized by ineffective erythropoiesis an...

Research Terms

<21+ years old><5-Azadeoxycytidine><5-deoxyazacytidine><AOF2><Adult><Adult Human><Alleles><Allelomorphs><Anemia><Binding><Blood Precursor Cell><Blood erythrocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><CD34><CD34 gene><CRE Recombinase><CRISPR><CRISPR activation><CRISPR activator><CRISPR based activation><CRISPR editing screen><CRISPR gene activation><CRISPR screen><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-based screen><CRISPR-dCAS9 Activator><CRISPR-mediated transcriptional activation><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/Cas system><CRISPR/Cas9 screen><CRISPR/dCas9 activation><CRISPR/dCas9-based transcriptional activation><CRISPRa><Capsid Proteins><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Line><Cell Survival><Cell Viability><CellLine><Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Coat Proteins><Complete Blood Count><Congenital dyserythropoietic anemia><Cultured Cells><DNA mutation><Decitabine><Defect><Deoxyazacytidine><Development><Dezocitidine><Disease><Disorder><Dose><Dysfunction><Embryo Development><Embryogenesis><Embryonic Development><Endoplasmic Reticulum><Enterobacteria phage P1 Cre recombinase><Epistasis><Epistatic Deviation><Ergastoplasm><Erythrocytes><Erythrocytic><Erythroid><Erythroid Cells><Erythropoiesis><Exhibits><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Foundations><Functional disorder><Funding><Genes><Genetic><Genetic Change><Genetic Diseases><Genetic Epistasis><Genetic defect><Genetic mutation><Golgi><Golgi Apparatus><Golgi Complex><HPCA1><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Histology><Human><Impairment><In Vitro><Interaction Deviation><KDM1A><KDM1A gene><Knock-out><Knockout><Knowledge><LSD1><Libraries><Lysine-Specific Demethylase 1><Lysine-Specific Demethylase 1A><Marrow erythrocyte><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Interaction><Morbidity><Murine><Mus><Mutation><Pathogenesis><Pathway interactions><Peripheral><Phenotype><Phlebotomy><Physiopathology><Play><Production><Proerythroblast><Pronormoblasts><Red Blood Cells><Red Cell><Reporter><Role><Source><Spleen><Spleen Reticuloendothelial System><Strains Cell Lines><Stress><Testing><Therapeutic><Validation><Variant><Variation><Venous blood sampling><Vesicle><Viral Coat Proteins><Viral Outer Coat Protein><activating CRISPR technology><adulthood><autosome><bacteriophage P1 recombinase Cre><blood cell progenitor><blood corpuscles><blood progenitor><blood stem cell><blood-forming stem cell><cellular differentiation><clustered regularly interspaced short palindromic repeats screen><combinatorial><compound repositioning><compound repurposing><cultured cell line><developmental><drug repositioning><drug repurposing><epistatic interaction><epistatic relationship><erythroid development><erythroid differentiation><experiment><experimental research><experimental study><experiments><flow cytophotometry><gene x gene interaction><genetic condition><genetic disorder><genetic epistases><genome mutation><genome scale><genome-wide><genomewide><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><in vivo><inhibitor><loss of function mutation><mortality><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic uses for existing drugs><new therapeutics><new therapy><new use of drug><new uses for an approved drug><new uses for existing drugs><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><paralog><paralogous gene><pathophysiology><pathway><pharmacological repurposing><phenylhydrazide><phenylhydrazine><promoter><promotor><protein complex><repositioning approved drugs><repositioning existing drugs><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><secretory protein><social role><therapeutic repositioning><therapeutic repurposing><validations>

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Bo Ning

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$738,400

FY 2026

Project Title

CRISPR detection of circulating cell-free Mycobacterium avium complex (MAC) DNA for rapid diagnosis and monitoring of MAC pulmonary disease

Grant Number:

5R01AI177986-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/19/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Nontuberculous mycobacteria (NTM) are opportunistic environmental pathogens that are present in soil and water. NTMpulmonary infections, most commonly due to Mycobacterium avium complex (MAC), may result in chronic, debilitating pulmonary disease (MAC-PD). Treatment, when ne...

Research Terms

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Kevin Loring Winthrop

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$738,400

FY 2026

Project Title

CRISPR detection of circulating cell-free Mycobacterium avium complex (MAC) DNA for rapid diagnosis and monitoring of MAC pulmonary disease

Grant Number:

5R01AI177986-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/19/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Nontuberculous mycobacteria (NTM) are opportunistic environmental pathogens that are present in soil and water. NTMpulmonary infections, most commonly due to Mycobacterium avium complex (MAC), may result in chronic, debilitating pulmonary disease (MAC-PD). Treatment, when ne...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Gerd A Blobel

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$729,938

FY 2026

Project Title

Targeted protein degraders for the treatment of b-hemoglobinopathies

Grant Number:

5R01HL176850-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Globally, 300,000 babies are born annually with Sickle Cell Disease (SCD). Current therapies for SCD revolve around induction of fetal hemoglobin (HbF), as it critically antagonizes red blood cell sickling. For example, hydroxyurea, a ribonucleotide reductase inhibitor, increases HbF levels. While h...

Research Terms

<21+ years old><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Assay><Attention><B-globin><Basal Transcription Factor><Basal transcription factor genes><Binding><Bioassay><Bioavailability><Biological><Biological Assay><Biological Availability><Birth><Blood><Blood Reticuloendothelial System><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><CD34><CD34 gene><CHD4><CHD4 gene><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Carrying Capacities><Cas nuclease technology><Casein Kinase 1><Cell Body><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Survival><Cell Viability><Cell surface><Cells><Cellular Proliferation><Chromodomain Helicase DNA-Binding Protein 4><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Complete Blood Count><Control Animal><Crystallization><DNA Therapy><DNA mutation><Data><Disease><Disorder><Drug Therapy><Drugs><E3 Ligase><E3 Ubiquitin Ligase><Enhancers><Erythroid><Erythroid Cells><Fetal Hb><Fetal Hemoglobin><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Gene Expression><Gene Transfer Clinical><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genetic Change><Genetic Intervention><Genetic Screening><Genetic defect><Genetic mutation><Globin><HPCA1><HPLC><Hb SS disease><HbF><HbSS disease><Hemoglobin><Hemoglobin F><Hemoglobin S Disease><Hemoglobin concentration result><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hemoglobinopathies><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Histologic><Histologically><Human><Hydroxycarbamid><Hydroxycarbamide><Hypoxia><Hypoxic><IMiD><IMiD3 cpd><Immune modulatory therapeutic><In vivo analysis><K562 Cells><Laboratories><Libraries><Luciferase Immunologic><Luciferases><Measurement><Medical><Medication><Medicinal Chemistry><Messenger RNA><Metabolic><Methods><Mi2-Beta><Mice><Mice Mammals><Modern Man><Molecular><Molecular Interaction><Monitor><Murine><Mus><Mutation><O element><O2 element><Oral><Osmolar Concentration><Osmolarity><Oxygen><Oxygen Deficiency><Parturition><Patients><Pharmaceutic Chemistry><Pharmaceutical Chemistry><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiologic Availability><Point Mutation><Prevention><Production><Proliferating><Property><Protein Kinase CK1><Protein Kinase CKI><Proteins><Publishing><Renal function><Reticulocyte Number><Reticulocyte count><Ribonucleotide Reductase Inhibitor><Risk><Severity of illness><Sickle Cell><Sickle Cell Anemia><Specificity><Spleen><Spleen Reticuloendothelial System><Structure><System><Therapeutic><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Promotion><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Urine><Variant><Variation><Zinc Finger Domain><Zinc Finger Motifs><Zinc Fingers><adulthood><analog><beta Globin><biologic><casein kinase I><co-repressor><corepressor><cost><disease model><disease severity><disorder model><drug intervention><drug treatment><drug/agent><experience><fetal><fetal form of hemoglobin><fetal globin><flow cytophotometry><gamma Globin><gene co-repressor><gene corepressor><gene editing method><gene editing methodology><gene editing strategy><gene editing techniques><gene repair therapy><gene therapy><gene-based therapy><gene-based treatment><gene-directed therapy><gene-editing approach><gene-targeted therapy><gene-targeted treatment><genetic co-repressor><genetic corepressor><genetic therapy><genome mutation><genomic therapy><global gene expression><global transcription profile><hemoglobin level><humanized mice><humanized mouse><hydroxy-urea><hydroxyurea><immune modulating agents><immune modulating drug><immune modulating therapeutics><immune modulatory agents><immune modulatory drugs><immunomodulating agents><immunomodulating drugs><immunomodulator agent><immunomodulator drug><immunomodulator medication><immunomodulator prodrug><immunomodulator therapeutic><immunomodulatory agents><immunomodulatory drugs><immunomodulatory therapeutics><improved><in vivo><in vivo evaluation><in vivo testing><kidney function><lenalidomide><mRNA><member><model of animal><mouse model><murine model><novel><p-Globin><patient variability><patient variation><peripheral blood><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pre-clinical><preclinical><prevent><preventing><sickle RBC><sickle cell crisis><sickle cell disease><sickle cell disorder><sickle crisis><sickle disease><sickle erythrocyte><sickle erythroid><sickle red blood cell><sicklemia><sickling><standard of care><therapeutic agent development><therapeutic development><transcription factor><transcriptome><tumor><ubiquitin-protein ligase><variability between patients><variation between patients><β-globin><γ-Globin>

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CRAIG M CREWS

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$729,938

FY 2026

Project Title

Targeted protein degraders for the treatment of b-hemoglobinopathies

Grant Number:

5R01HL176850-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Globally, 300,000 babies are born annually with Sickle Cell Disease (SCD). Current therapies for SCD revolve around induction of fetal hemoglobin (HbF), as it critically antagonizes red blood cell sickling. For example, hydroxyurea, a ribonucleotide reductase inhibitor, increases HbF levels. While h...

Research Terms

<21+ years old><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Assay><Attention><B-globin><Basal Transcription Factor><Basal transcription factor genes><Binding><Bioassay><Bioavailability><Biological><Biological Assay><Biological Availability><Birth><Blood><Blood Reticuloendothelial System><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><CD34><CD34 gene><CHD4><CHD4 gene><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Carrying Capacities><Cas nuclease technology><Casein Kinase 1><Cell Body><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Survival><Cell Viability><Cell surface><Cells><Cellular Proliferation><Chromodomain Helicase DNA-Binding Protein 4><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Complete Blood Count><Control Animal><Crystallization><DNA Therapy><DNA mutation><Data><Disease><Disorder><Drug Therapy><Drugs><E3 Ligase><E3 Ubiquitin Ligase><Enhancers><Erythroid><Erythroid Cells><Fetal Hb><Fetal Hemoglobin><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Gene Expression><Gene Transfer Clinical><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genetic Change><Genetic Intervention><Genetic Screening><Genetic defect><Genetic mutation><Globin><HPCA1><HPLC><Hb SS disease><HbF><HbSS disease><Hemoglobin><Hemoglobin F><Hemoglobin S Disease><Hemoglobin concentration result><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hemoglobinopathies><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Histologic><Histologically><Human><Hydroxycarbamid><Hydroxycarbamide><Hypoxia><Hypoxic><IMiD><IMiD3 cpd><Immune modulatory therapeutic><In vivo analysis><K562 Cells><Laboratories><Libraries><Luciferase Immunologic><Luciferases><Measurement><Medical><Medication><Medicinal Chemistry><Messenger RNA><Metabolic><Methods><Mi2-Beta><Mice><Mice Mammals><Modern Man><Molecular><Molecular Interaction><Monitor><Murine><Mus><Mutation><O element><O2 element><Oral><Osmolar Concentration><Osmolarity><Oxygen><Oxygen Deficiency><Parturition><Patients><Pharmaceutic Chemistry><Pharmaceutical Chemistry><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiologic Availability><Point Mutation><Prevention><Production><Proliferating><Property><Protein Kinase CK1><Protein Kinase CKI><Proteins><Publishing><Renal function><Reticulocyte Number><Reticulocyte count><Ribonucleotide Reductase Inhibitor><Risk><Severity of illness><Sickle Cell><Sickle Cell Anemia><Specificity><Spleen><Spleen Reticuloendothelial System><Structure><System><Therapeutic><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Promotion><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Urine><Variant><Variation><Zinc Finger Domain><Zinc Finger Motifs><Zinc Fingers><adulthood><analog><beta Globin><biologic><casein kinase I><co-repressor><corepressor><cost><disease model><disease severity><disorder model><drug intervention><drug treatment><drug/agent><experience><fetal><fetal form of hemoglobin><fetal globin><flow cytophotometry><gamma Globin><gene co-repressor><gene corepressor><gene editing method><gene editing methodology><gene editing strategy><gene editing techniques><gene repair therapy><gene therapy><gene-based therapy><gene-based treatment><gene-directed therapy><gene-editing approach><gene-targeted therapy><gene-targeted treatment><genetic co-repressor><genetic corepressor><genetic therapy><genome mutation><genomic therapy><global gene expression><global transcription profile><hemoglobin level><humanized mice><humanized mouse><hydroxy-urea><hydroxyurea><immune modulating agents><immune modulating drug><immune modulating therapeutics><immune modulatory agents><immune modulatory drugs><immunomodulating agents><immunomodulating drugs><immunomodulator agent><immunomodulator drug><immunomodulator medication><immunomodulator prodrug><immunomodulator therapeutic><immunomodulatory agents><immunomodulatory drugs><immunomodulatory therapeutics><improved><in vivo><in vivo evaluation><in vivo testing><kidney function><lenalidomide><mRNA><member><model of animal><mouse model><murine model><novel><p-Globin><patient variability><patient variation><peripheral blood><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pre-clinical><preclinical><prevent><preventing><sickle RBC><sickle cell crisis><sickle cell disease><sickle cell disorder><sickle crisis><sickle disease><sickle erythrocyte><sickle erythroid><sickle red blood cell><sicklemia><sickling><standard of care><therapeutic agent development><therapeutic development><transcription factor><transcriptome><tumor><ubiquitin-protein ligase><variability between patients><variation between patients><β-globin><γ-Globin>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JESSE M ENGREITZ

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$721,450

FY 2026

Project Title

Genome-wide maps of enhancer-gene regulation to link variants to functions

Grant Number:

1R01HG014216-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The human genome encodes over 2 million DNA regulatory elements called enhancers that control gene expression in specific cell types and states. Enhancers harbor tens of thousands of genetic variants that influence risk for common diseases and traits. Each of these enhancer variants ...

Research Terms

<21+ years old><ATAC sequencing><ATAC-seq><ATACseq><Address><Adult><Adult Human><Affect><Age><Assay for Transposase-Accessible Chromatin using sequencing><Benchmarking><Best Practice Analysis><Biological><Biology><Body Tissues><CRISPR><CRISPR approach><CRISPR based approach><CRISPR interference><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR-dCas9-mediated repression><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiovascular Diseases><Cas nuclease technology><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chromatin><Chromosome Mapping><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats interference><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Communities><Complex><Computer Models><Computer software><Computerized Models><Computing Methodologies><Congenital Cardiac Defects><Congenital Heart Defects><DNA><DNase I hypersensitive sites sequencing><DNase-seq><DNaseI-seq><Data><Data Set><Deoxyribonucleic Acid><Disease><Disorder><Elements><Enhancers><Fetal Heart><Functional RNA><Future><GWA study><GWAS><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Regulation><Gene Regulation Process><Gene variant><Genes><Genetic Diversity><Genetic Risk><Genetic Variation><Genome><Genomics><Glean><Guidelines><Health><Heart><Heart Diseases><Human><Human Figure><Human Genome><Human body><Individual><Investigators><Link><Linkage Mapping><Maps><Measurement><Methods><Modeling><Modern Man><Molecular><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Organoids><Outcome><Pathway interactions><Play><Predicting Risk><RNA><RNA Gene Products><Regulation><Regulatory Element><Research Personnel><Research Resources><Researchers><Resources><Ribonucleic Acid><Risk><Risk-associated variant><Role><Software><Stress Tests><Structure><Subcellular Process><System><Technology><Testing><Tissues><Total Human and Non-Human Gene Mapping><Untranslated RNA><Variant><Variation><Work><adulthood><ages><allelic variant><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><benchmark><biologic><biological sex><cardiovascular disorder><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cell type><computational methodology><computational methods><computational modeling><computational models><computer based method><computer based models><computer based prediction><computer methods><computerized modeling><computing method><disease risk><disorder risk><drug development><epigenomics><forecasting risk><gene interaction><gene locus><genetic locus><genetic mapping><genetic variant><genome scale><genome wide analysis><genome wide association><genome wide association scan><genome wide association study><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><genomewide association scan><genomewide association study><genomic location><genomic locus><genomic variant><heart disorder><human disease><human whole genome><innovate><innovation><innovative><insight><multiomics><multiple omics><noncoding><novel><panomics><pathway><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive modeling><predictive risk><predicts risk><repressing CRISPR-dCas9 system><risk allele><risk gene><risk genotype><risk loci><risk locus><risk prediction><risk predictions><risk variant><sex><social role><tool><trait><whole genome association analysis><whole genome association study>

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RON R KOPITO

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$704,810

FY 2026

Project Title

Pharmacogenomic discovery of therapeutic targets for corrector-refractory cystic fibrosis

Grant Number:

5R01HL172845-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/10/2024

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Chronic lung disease is the main cause of morbidity and mortality in cystic fibrosis (CF), a fatal genetic disorder caused by mutations in CFTR, a Cl– ion channel in the plasma membrane (PM) of the airway mucosa. Over 80% of people with CF (pwCF) have mutations that interfere with folding o...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><AAT deficiency><Affect><Airway failure><Airway infections><Airway mucosa><American><Assay><Binding><Bioassay><Biological Assay><Biological Response Modifier Therapy><Biological Therapy><Bronchiectasis><CFTR><CFTR Protein><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><Cell Body><Cell membrane><Cells><Chaperone><Chemicals><Chloride Channels><Chloride Ion Channels><Chronic lung disease><Clinic><Clustered Regularly Interspaced Short Palindromic Repeats><Cystic Fibrosis><Cystic Fibrosis Transmembrane Conductance Regulator><Cytoplasmic Membrane><DNA mutation><Data><Delta F508 mutation><Development><Drug Combinations><Drug Targeting><Drug Therapy><Drugs><Electrophysiology><Electrophysiology (science)><Eligibility><Eligibility Determination><Endoplasmic Reticulum><Epistasis><Epistatic Deviation><Epithelial Cells><Ergastoplasm><F508 deletion><F508 mutation><F508-del><F508del><FDA approved><Generations><Genes><Genetic><Genetic Change><Genetic Diseases><Genetic Epistasis><Genetic defect><Genetic mutation><Goals><Hospital Admission><Hospitalization><Human><Human Genetics><Impairment><In Vitro><Interaction Deviation><Ion Channel><Ionic Channels><Ivacaftor><Kinetics><Knowledge><Length><Lung Diseases><Macropain><Macroxyproteinase><Maps><Measures><Mediating><Medical><Medication><Membrane Channels><Methodology><Modern Man><Molecular Chaperones><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Morbidity><Mucociliary Clearance><Mucociliary Transport><Mucoviscidosis><Multicatalytic Proteinase><Mutation><Neurophysiology / Electrophysiology><Pathway interactions><Patients><Persons><Pharmaceutical Preparations><Pharmacogenomics><Pharmacological Treatment><Pharmacotherapy><Plasma Membrane><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteosome><Protocol Screening><Publishing><Pulmonary Diseases><Pulmonary Disorder><Qualifying><Quality Control><Recurrence><Recurrent><Refractory><Reporter><Reporting><Resistance><Respiratory Epithelium><Respiratory Failure><Respiratory Infections><Respiratory Mucosa><Respiratory Tract Infections><Secondary to><Structural defect><Structural malformation><Structure of respiratory epithelium><System><Technology><Testing><Therapeutic><Therapeutic Uses><Triage><VX-770><Validation><Variant><Variation><Work><a1-antitrypsin deficiency><airway epithelium><airway injury><alpha 1-Antitrypsin Deficiency><alpha-1-anti-trypsin deficiency><alpha1-antitrypsin deficiency><basal progenitor><basal stem cell><biological therapeutic><biological treatment><biologically based therapeutics><biotherapeutics><biotherapy><candidate validation><cellular targeting><chronic pulmonary disease><clustered regularly interspaced short palindromic repeats screen><conformation><conformational><conformational state><conformationally><conformations><cystic fibrosis transmembrane regulator><design><designing><developmental><disease of the lung><disorder of the lung><drug intervention><drug treatment><drug/agent><electrophysiological><epistatic interaction><epistatic relationship><functional genomics><gain of function><gene x gene interaction><genetic condition><genetic disorder><genetic epistases><genome mutation><genome scale><genome-wide><genomewide><impaired airway><improved><injured airway><loss of function><loss of function mutation><lung disorder><lung function><mortality><multicatalytic endopeptidase complex><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><pathway><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><plasmalemma><posters><protein complex><pulmonary function><resistant><respiratory injury><respiratory tract epithelium><respiratory tract injury><response><standard of care><structural abnormalities><structural anomalies><success><synergism><therapeutic target><trafficking><validations><ΔF508><α-1 anti-trypsin deficiency><α-1-antitrypsin deficiency><α1-Antitrypsin Deficiency>

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Gustavo Enrique Ayala

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$683,166

FY 2026

Project Title

Artificial intelligence enabled Stroma-Weighted Automated Grading system to improve risk stratification in Black Men

Grant Number:

5R01CA290438-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/12/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY / ABSTRACT A significant disparity in prostate cancer (PCa)-associated mortality is observed in Black men, who are twice as likely to die of prostate cancer than White men. Multiple factors contribute to Black men’s disproportionately higher cancer burden. Our group and others have d...

Research Terms

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Surinder K. Batra

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$683,166

FY 2026

Project Title

Artificial intelligence enabled Stroma-Weighted Automated Grading system to improve risk stratification in Black Men

Grant Number:

5R01CA290438-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/12/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY / ABSTRACT A significant disparity in prostate cancer (PCa)-associated mortality is observed in Black men, who are twice as likely to die of prostate cancer than White men. Multiple factors contribute to Black men’s disproportionately higher cancer burden. Our group and others have d...

Research Terms

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Ashutosh K Tewari

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$683,166

FY 2026

Project Title

Artificial intelligence enabled Stroma-Weighted Automated Grading system to improve risk stratification in Black Men

Grant Number:

5R01CA290438-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/12/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY / ABSTRACT A significant disparity in prostate cancer (PCa)-associated mortality is observed in Black men, who are twice as likely to die of prostate cancer than White men. Multiple factors contribute to Black men’s disproportionately higher cancer burden. Our group and others have d...

Research Terms

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Claire Clelland

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$680,792

FY 2026

Project Title

CRISPR for tauopathy

Grant Number:

1R01AG092420-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Dementia, including Alzheimer’s disease (AD) and frontotemporal dementia (FTD), are major contributors to mortality, morbidity, and worldwide healthcare expenditure. FTD is fatal and incurable and represents 10-20% of all dementia cases. Approximately 9% of all FTD cases are caused b...

Research Terms

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Kevin J Bender

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$672,761

FY 2026

Project Title

CRISPRa-based rescue of sensorimotor deficits in the Scn2a+/- mouse model of autism spectrum disorder

Grant Number:

5R01MH136475-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Title: CRISPRa-based rescue of sensorimotor deficits in the Scn2a+/- mouse model of autism spectrum disorder Project Summary: Heterozygous loss-of-function mutations in the sodium channel gene SCN2A are strongly associated with autism spectrum disorder. SCN2A encodes the neuronal sodium channel NaV1...

Research Terms

<12-20 years old><21+ years old><ASD><Action Potentials><Acute><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Alleles><Allelic Loss><Allelomorphs><Animals><Area><Autism><Autistic Disorder><Axon><Behavior><Behavioral><Biological Markers><Brain><Brain Nervous System><Brain region><CRISPR activation><CRISPR activator><CRISPR based activation><CRISPR gene activation><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-dCAS9 Activator><CRISPR-mediated transcriptional activation><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/dCas9 activation><CRISPR/dCas9-based transcriptional activation><CRISPRa><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cerebellum><Code><Coding System><Cytoplasmic Granules><DNA Therapy><Data><Dendrites><Development><Disease><Disorder><Dysfunction><EEG><Early Infantile Autism><Electrocorticogram><Electroencephalogram><Electroencephalography><Encephalon><Enhancers><Exhibits><Frequencies><Functional disorder><Gene Expression><Gene Transfer Clinical><Genes><Genetic><Genetic Intervention><Goals><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Impairment><Infantile Autism><Intervention><Kanner's Syndrome><Laboratories><Learning><Link><Loss of Heterozygosity><Maps><Membrane><Methods><Mice><Mice Mammals><Modeling><Modern Man><Morbid Obesity><Motor><Murine><Mus><Nav1.2><Neocortex><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Phenotype><Physiologic><Physiological><Physiology><Physiopathology><Population><Position><Positioning Attribute><Prefrontal Cortex><Preparation><Proteins><Purkinje Cells><Purkinje's Corpuscles><Pyramidal Cells><Reagent><Reflex><Reflex action><Risk-associated variant><SCN2A protein><Sensory><Severe obesity><Sodium Channel><Sodium Ion Channels><Somatosensory Cortex><Space Perception><Spatial Discrimination><Specificity><Subcellular Process><Synapses><Synaptic><Synaptic plasticity><System><Testing><Therapeutic><Therapeutic Intervention><Touch><Touch sensation><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcriptional Activator/Coactivator><Transmission><Upregulation><Vibrissae><Visual><Whiskers><Work><activating CRISPR technology><adolescence (12-20)><adulthood><assess effectiveness><autism model><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior phenotype><behavioral impairment><behavioral phenotyping><bio-markers><biologic marker><biomarker><cerebellar Purkinje cell><critical developmental period><critical period><determine effectiveness><determine efficacy><developmental><effective intervention><effectiveness assessment><effectiveness evaluation><effectiveness testing><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electrocorticography><evaluate effectiveness><evaluate efficacy><examine effectiveness><examine efficacy><experiment><experimental research><experimental study><experiments><extreme obesity><functional genomics><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><granule><granule cell><homotypical cortex><iPS><iPSC><iPSCs><impaired behavior><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intervention therapy><isocortex><juvenile><juvenile human><loss of function><loss of function mutation><membrane structure><model of autism spectrum disorder><mouse model><murine model><na(v)1.2><neocortical><neopallium><neural><neurodevelopmental disease><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oculovestibular reflex><pathophysiology><perceptual spatial orientation><postsynaptic><preparations><promoter><promotor><repetitive behavior><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sensory cortex><social communication impairment><somatosensory><somesthetic sensory cortex><spatial orientation><spatial perception><synapse><synapse function><synaptic function><tactile sensation><transmission process><vestibo-ocular reflexes><vestibulo-occular system><vestibulo-ocular reflex><vestibulo-oculomotor reflex><vestibuloocular reflexes><voltage>

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Daniel Feldman

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$672,761

FY 2026

Project Title

CRISPRa-based rescue of sensorimotor deficits in the Scn2a+/- mouse model of autism spectrum disorder

Grant Number:

5R01MH136475-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Title: CRISPRa-based rescue of sensorimotor deficits in the Scn2a+/- mouse model of autism spectrum disorder Project Summary: Heterozygous loss-of-function mutations in the sodium channel gene SCN2A are strongly associated with autism spectrum disorder. SCN2A encodes the neuronal sodium channel NaV1...

Research Terms

<12-20 years old><21+ years old><ASD><Action Potentials><Acute><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Alleles><Allelic Loss><Allelomorphs><Animals><Area><Autism><Autistic Disorder><Axon><Behavior><Behavioral><Biological Markers><Brain><Brain Nervous System><Brain region><CRISPR activation><CRISPR activator><CRISPR based activation><CRISPR gene activation><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-dCAS9 Activator><CRISPR-mediated transcriptional activation><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/dCas9 activation><CRISPR/dCas9-based transcriptional activation><CRISPRa><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cerebellum><Code><Coding System><Cytoplasmic Granules><DNA Therapy><Data><Dendrites><Development><Disease><Disorder><Dysfunction><EEG><Early Infantile Autism><Electrocorticogram><Electroencephalogram><Electroencephalography><Encephalon><Enhancers><Exhibits><Frequencies><Functional disorder><Gene Expression><Gene Transfer Clinical><Genes><Genetic><Genetic Intervention><Goals><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Impairment><Infantile Autism><Intervention><Kanner's Syndrome><Laboratories><Learning><Link><Loss of Heterozygosity><Maps><Membrane><Methods><Mice><Mice Mammals><Modeling><Modern Man><Morbid Obesity><Motor><Murine><Mus><Nav1.2><Neocortex><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Phenotype><Physiologic><Physiological><Physiology><Physiopathology><Population><Position><Positioning Attribute><Prefrontal Cortex><Preparation><Proteins><Purkinje Cells><Purkinje's Corpuscles><Pyramidal Cells><Reagent><Reflex><Reflex action><Risk-associated variant><SCN2A protein><Sensory><Severe obesity><Sodium Channel><Sodium Ion Channels><Somatosensory Cortex><Space Perception><Spatial Discrimination><Specificity><Subcellular Process><Synapses><Synaptic><Synaptic plasticity><System><Testing><Therapeutic><Therapeutic Intervention><Touch><Touch sensation><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcriptional Activator/Coactivator><Transmission><Upregulation><Vibrissae><Visual><Whiskers><Work><activating CRISPR technology><adolescence (12-20)><adulthood><assess effectiveness><autism model><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior phenotype><behavioral impairment><behavioral phenotyping><bio-markers><biologic marker><biomarker><cerebellar Purkinje cell><critical developmental period><critical period><determine effectiveness><determine efficacy><developmental><effective intervention><effectiveness assessment><effectiveness evaluation><effectiveness testing><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electrocorticography><evaluate effectiveness><evaluate efficacy><examine effectiveness><examine efficacy><experiment><experimental research><experimental study><experiments><extreme obesity><functional genomics><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><granule><granule cell><homotypical cortex><iPS><iPSC><iPSCs><impaired behavior><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intervention therapy><isocortex><juvenile><juvenile human><loss of function><loss of function mutation><membrane structure><model of autism spectrum disorder><mouse model><murine model><na(v)1.2><neocortical><neopallium><neural><neurodevelopmental disease><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oculovestibular reflex><pathophysiology><perceptual spatial orientation><postsynaptic><preparations><promoter><promotor><repetitive behavior><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sensory cortex><social communication impairment><somatosensory><somesthetic sensory cortex><spatial orientation><spatial perception><synapse><synapse function><synaptic function><tactile sensation><transmission process><vestibo-ocular reflexes><vestibulo-occular system><vestibulo-ocular reflex><vestibulo-oculomotor reflex><vestibuloocular reflexes><voltage>

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Trey Ideker

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$665,655

FY 2026

Project Title

Next generation massively multiplexed combinatorial genetic screens

Grant Number:

5R01HG012351-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Genes and variants often act in combination to drive cellular and organismal phenotypes. Mapping these functional interactions advances our fundamental understanding of biological systems and has broad applicability to therapeutics development. Gene-gene interactions also li...

Research Terms

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Prashant Mali

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$665,655

FY 2026

Project Title

Next generation massively multiplexed combinatorial genetic screens

Grant Number:

5R01HG012351-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Genes and variants often act in combination to drive cellular and organismal phenotypes. Mapping these functional interactions advances our fundamental understanding of biological systems and has broad applicability to therapeutics development. Gene-gene interactions also li...

Research Terms

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Xiaoqiu Wang

NORTH CAROLINA STATE UNIVERSITY RALEIGH, RALEIGH, NC

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$650,546

FY 2026

Project Title

Deciphering molecular mechanisms controlling age-associated uterine adaptabilityto pregnancy

Grant Number:

5R01HD111463-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Advanced maternal age (i.e., ≥35 years old) is considered a major risk factor for birth defects. In women over 40 years of age, the incidence of spontaneous abortion can increase to >30%. Much attention has been focused on ovarian function and oocyte quality, but we provide evidence ...

Research Terms

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Shana O Kelley

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$650,480

FY 2026

Project Title

A microfluidic platform for high performance sorting of immune cells based on their distinct secretion patterns

Grant Number:

5R01AI181023-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/9/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Cellular heterogeneity limits the identification of regulatory networks that control specific cellular functions such as cell secretion. This is particularly challenging for deciphering cellular immunity as immune responses often involve intermediate extracellular signalling acting a...

Research Terms

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IRFAN RAHMAN

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$635,461

FY 2026

Project Title

Aberrant Micro-managing of the Airway Epithelial Transcriptome in HIV-associated COPD

Grant Number:

5R01HL167655-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The long-term goal of this proposal is to identify the pathophysiology underlying HIV associated COPD. People living with HIV (PLWH) show increased incidence of COPD even when compensated for smoking status. MicroRNAs manage the cellular transcriptome and play important roles in hea...

Research Terms

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HOSHANG JEHANGIR UNWALLA

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$635,461

FY 2026

Project Title

Aberrant Micro-managing of the Airway Epithelial Transcriptome in HIV-associated COPD

Grant Number:

5R01HL167655-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The long-term goal of this proposal is to identify the pathophysiology underlying HIV associated COPD. People living with HIV (PLWH) show increased incidence of COPD even when compensated for smoking status. MicroRNAs manage the cellular transcriptome and play important roles in hea...

Research Terms

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Hong Li

VAN ANDEL RESEARCH INSTITUTE, GRAND RAPIDS, MI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$625,736

FY 2026

Project Title

Mechanisms and Applications of RNA-mediated Enzymes in Translation and Immunity

Grant Number:

5R35GM152081-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/12/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Description: RNA-guided, or ribonucleoprotein particle (RNP), enzymes comprise an emerging class of molecules that function in a wide range of biological pathways. Unlike most of the protein-based enzymes, RNP enzymes rely on the guide RNA to secure the substrates and on the partner proteins to cata...

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SCOTT H SODERLING

DUKE UNIVERSITY, DURHAM, NC

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$619,580

FY 2026

Project Title

Neuronal Kinase Signaling in Health and Disease

Grant Number:

1R01NS147032-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Kinase signaling plays a pivotal role in regulating neuronal physiology, yet the mechanisms underlying kinase specificity, subcellular compartmentalization, and disease-associated dysfunction remain poorly understood. Dysregulated kinase activity is a key driver of neurodegenerative disorde...

Research Terms

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Kodi S Ravichandran

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$610,767

FY 2026

Project Title

Solute carrier proteins and metal ion-based signaling during efferocytosis

Grant Number:

2R01AI159551-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/25/2021

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Abstract The phagocytosis of apoptotic cells or “efferocytosis, represents a fascinating and complex challenge for phagocytes. These specialized cells must simultaneously process the various components of ingested cellular debris, produce anti-inflammatory mediators, and maintain their own h...

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Mats Ljungman

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$582,849

FY 2026

Project Title

Precision targeting of bladder cancer using CRISPR

Grant Number:

5R01CA285730-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/9/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Chromosome rearrangements (structural variants) are common in cancer and they drive tumor development by altering the expression or function of oncogenes and tumor suppressor genes by copy number alterations, formation of oncogenic fusions or by alterations of DNA elements responsible for r...

Research Terms

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MATTHEW N RASBAND

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$558,467

FY 2026

Project Title

Oligodendroglial ANK3 and its role in CNS function

Grant Number:

2R01MH121544-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2019

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Bipolar disorder (BD) is a severe neuropsychiatric disease that affects ~3 million Americans. Importantly, BD is highly heritable, suggesting the cause is mostly genetic. Genome-wide association studies (GWAS) revealed ~30 genes linked to BD. Among these, ANK3 (the gene coding for A...

Research Terms

<21+ years old><ANK3><ANK3 gene><Adhesion Molecule><Adult><Adult Human><Affect><Affinity><Age><Aging><American><Ankyrin 3><Ankyrin-G><Axon><Behavior><Behavioral><Binding><Biotin><Biotinylation><Bipolar Affective Psychosis><Bipolar Disorder><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Communication and Signaling><Cell Junctions><Cell Signaling><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complex><Defect><Demyelinations><Development><Disease><Disorder><Disturbance in cognition><Electron Microscopy><Electrophysiology><Electrophysiology (science)><GWA study><GWAS><Gene Expression><Genes><Genetic><Glia><Glial Cells><Heritability><Immunofluorescence Microscopy><Impaired cognition><Intercellular Junctions><Intracellular Communication and Signaling><K channel><KI mice><Knock-in Mouse><Knock-out><Knockout><Kolliker's reticulum><Link><Location><Maintenance><Manic-Depressive Psychosis><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mice><Mice Mammals><Molecular><Molecular Interaction><Moods><Murine><Mus><Myelin><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Neurophysiology / Electrophysiology><Non-neuronal cell><Nonneuronal cell><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Pathology><Phenotype><Potassium Channel><Potassium Ion Channels><Proteins><Proteome><Proteomics><RNA Splicing><Ranvier's Nodes><Receptor Protein><Reporting><Reproducibility><Risk-associated variant><Role><Scaffolding Protein><Signal Transduction><Signal Transduction Systems><Signaling><Site><Splicing><Strepavidin><Streptavidin><Structure><Symptoms><Treatment Efficacy><Variant><Variation><Vitamin H><White Matter Hyperintensity><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged mice><aged mouse><ages><biological signal transduction><bipolar affective disorder><bipolar disease><bipolar illness><bipolar mood disorder><cell adhesion protein><coenzyme R><cognitive dysfunction><cognitive loss><demyelinate><developmental><elderly mice><electrophysiological><experiment><experimental research><experimental study><experiments><gene editing platform><gene editing system><gene editing technology><gene editing tools><gene-editing toolkit><genome editing><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic editing><in vivo><intervention efficacy><knockin mice><knockout gene><manic depressive disorder><manic depressive illness><myelination><nerve cement><neurofascin><neuronal><neuropsychiatric disease><neuropsychiatric disorder><old mice><overexpress><overexpression><protein function><receptor><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><screening><screenings><social role><substantia alba><superresolution imaging><therapeutic efficacy><therapy efficacy><white matter><whole genome association analysis><whole genome association study>

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Alice Berger

FRED HUTCHINSON CANCER CENTER, SEATTLE, WA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$530,439

FY 2026

Project Title

Expanding the cancer paralog genetic interaction map to enable precision oncology

Grant Number:

5R01CA262556-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Recent advances in targeted therapies have prolonged the survival of non-small cell lung cancer patients. However, lung cancer still remains the leading cause of cancer deaths in the U.S. and worldwide, and the 5-year survival rate for non-small cell lung cancer is a dismal ...

Research Terms

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Daniel Charles Castro

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$523,855

FY 2026

Project Title

Investigating non-canonical mechanisms of endogenous opioids on motivation in dorsal midbrain

Grant Number:

5R01MH132504-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/9/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The primary goal of this R01 is to determine the computational and functional role of endogenous opioids in specific dorsal midbrain nuclei on motivated behaviors. The preponderance of mental illness in the United States results in tens of millions of dollars in healthcare costs. Whi...

Research Terms

<21+ years old><Active Follow-up><Adult><Adult Human><Affect><Affective><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anatomic Sites><Anatomic structures><Anatomy><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Appetite><Appetite stimulated><Behavior><Behavioral><Biological><Bite><Brain><Brain Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Calcium><Cas nuclease technology><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Characteristics><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Color><Data><Desire for food><Devices><Dissociation><Dorsal><E-stim><Eating><Electric Stimulation><Encephalon><Endoscopy><Enkephalin Receptors><Enkephalins><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Food Intake><Genetic><Goals><Health Care Costs><Health Costs><Image><Increased food appetite><Individual><Infumorph><Intracellular Communication and Signaling><Kadian><Lateral><Ligands><MS Contin><MSir><Measures><Mediating><Mental disorders><Mental health disorders><Mesencephalic Central Gray><Mesencephalon><Mice><Mice Mammals><Microinjections><Mid-brain><Midbrain><Midbrain Central Gray><Midbrain structure><Moods><Morphia><Morphine><Motivation><Murine><Mus><NIMH><National Institute of Mental Health><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nucleus><Nucleus Accumbens><Opiate Peptides><Opiate Receptors><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid Peptide><Opioid Receptor><Opioid agonist><Opioid receptor agonist><Opsin><Oramorph><Oramorph SR><Pattern><Peptides><Periaqueductal Gray><Pharmacology><Phenotype><Photons><Pilot Projects><Play><Process><Psychiatric Disease><Psychiatric Disorder><Receptor Protein><Regulation><Rewards><Rod-Opsin><Role><Roxanol><Signal Transduction><Signal Transduction Systems><Signaling><Site><Statex SR><Strategic Planning><System><Tail><Technology><Testing><Therapeutic Intervention><United States><Virus><active followup><adulthood><annulus of the aqueduct><antagonism><antagonist><behavior test><behavioral test><biologic><biological adaptation to stress><biological signal transduction><calcium indicator><cell type><delta opioid receptor><design><designing><dorsal raphe nucleus><electrostimulation><endogenous opiate><endogenous opioids><endoscopic imaging><experience><experiment><experimental research><experimental study><experiments><fluorophore><follow up><follow-up><followed up><followup><imaging><imaging in vivo><in vivo imaging><increased appetite><increased hunger><insight><intervention therapy><knock-down><knockdown><mental illness><midbrain central gray substance><motivated behavior><mu receptors><neural><neural circuit><neural circuitry><neural control><neural regulation><neurobiological mechanism><neurochemical><neurochemistry><neurocircuitry><neuromodulation><neuromodulatory><neuronal><neuropsychiatric><neuropsychiatric disease><neuropsychiatric disorder><neuropsychiatry><neuroregulation><next generation><optogenetics><pain killer><pain medication><pain reliever><painkiller><periaqueductal gray matter><pharmacologic><pilot study><psychiatric illness><psychological disorder><reactioncrisis><receptor><receptor expression><redshift><response><social role><stress response><stressreaction><synaptic circuit><synaptic circuitry><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><wireless><wireless implant><δ OR><δ ORs><δ opioid receptors><δ-OR><δ-ORs><δOR><δORs><μ receptors>

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Qing Zhang

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$521,579

FY 2026

Project Title

Genome-wide CRISPR screening identifies critical regulators controlling ccRCC lung metastasis

Grant Number:

5R01CA294133-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Clear cell renal cell carcinoma (ccRCC), which accounts for approximately 85% of all renal cancers, is resistant to a variety of cancer therapies and is highly lethal. Metastasis poses a significant challenge in the treatment of kidney cancer, with lung metastasis accounting for approximately 40-50%...

Research Terms

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Jesse Warren Williams

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$517,890

FY 2026

Project Title

Regulation of Foamy Macrophage Differentiation and Survival in Atherosclerosis

Grant Number:

5R01HL166843-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract: Atherosclerosis is a disease of the mid- and large-sized arteries that promotes plaque formation. Plaque development can lead to restricted blood flow, vessel rigidity, and in some cases thrombosis. Atherosclerosis is a major underlying condition that promotes the morbidity...

Research Terms

<1-Phosphatidylinositol 3-Kinase><AKT><ASCVD><Address><Adipose tissue><Agonist><Akt protein><Antibodies><Aorta><Apoplexy><Arterial Fatty Streak><Arterial Intimas><Arteries><Atheroma><Atheromatous><Atheromatous degeneration><Atheromatous plaque><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Binding><Blood Serum><Blood flow><Blood monocyte><Brain Vascular Accident><CRISPR approach><CRISPR based approach><CRISPR editing screen><CRISPR method><CRISPR methodology><CRISPR screen><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based screen><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 screen><CRISPR/Cas9 technology><Cardiac Diseases><Cardiac Disorders><Cardiovascular Diseases><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Death><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cell Survival><Cell Viability><Cells><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chimera><Chimera organism><Cholesterol><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complement><Complement Proteins><Data><Deposit><Deposition><Development><Disease><Disease Progression><Disorder><Drugs><Dysfunction><ER stress><Exposure to><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Fatty Tissue><Foamy Macrophage><Functional disorder><Future><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Genes><Heart Diseases><Hortega cell><Hypercholesteremia><Immune><Immunes><In Vitro><Infiltration><Inflammatory><Intervention><Intracellular Communication and Signaling><Ischemia><Knock-out><Knockout><Knowledge><LXR-alpha protein><LXRA gene product><LXRalpha><LXRalpha protein><LXRα><Lesion><Lipid-Laden Macrophage><Lipids><Macrophage><Maps><Marrow monocyte><Mechanistic Target of Rapamycin><Mediating><Medication><Metabolic><Metabolic dysfunction><Mice><Mice Mammals><Microglia><Modeling><Molecular Interaction><Morbidity><Murine><Mus><Myelogenous><Myeloid><Myeloid Cells><MΦ foam cell><Mφ><Necrosis><Necrotic><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><Pathway interactions><Patients><Pharmaceutical Preparations><Phenotype><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Physiopathology><Plaque Instability><Play><Position><Positioning Attribute><Predisposition><Proliferating><Protein Kinase B><Proto-Oncogene Proteins c-akt><PtdIns 3-Kinase><Publishing><RAC-PK protein><RAFT1><Regulation><Resolution><Risk Factors><Role><Rupture><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Stroke><Susceptibility><TREM2><TREM2 gene><Tamoxifen><Testing><Therapeutic><Thrombosis><Transcript Expression Analyses><Transcript Expression Analysis><Translations><Triggering Receptor Expressed in Myeloid Cells 2><Triggering Receptor Expressed on Myeloid Cells 2><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><Viral><adipose><analyze gene expression><atheromatosis><atherosclerosis plaque><atherosclerotic disease><atherosclerotic lesions><atherosclerotic plaque><atherosclerotic vascular disease><biological signal transduction><brain attack><c-akt protein><cardiovascular disorder><cell type><cellular differentiation><cerebral vascular accident><cerebrovascular accident><chimeras><clustered regularly interspaced short palindromic repeats screen><complementation><developmental><drug/agent><endoplasmic reticulum stress><experience><experiment><experimental research><experimental study><experiments><fat metabolism><gene expression analysis><gene expression assay><genome editing><genome scale><genome-wide><genomewide><genomic editing><gitter cell><heart disorder><high blood cholesterol><high risk><hypercholesterolemia><improved outcome><in vivo><knowledge translation><lipid metabolism><liver X receptor alpha><liver X receptor α><mTOR><mammalian target of rapamycin><mesoglia><microglial cell><microgliocyte><monocyte><mortality><mouse model><murine model><mutant><necrocytosis><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><orphan nuclear receptor LXR-alpha><ox-LDL><oxidized LDL><oxidized low density lipoprotein><oxysterols receptor LXR-alpha><pathophysiology><pathway><perivascular glial cell><plaque vulnerability><plaques in atherosclerosis><primary outcome><proto-oncogene protein RAC><proto-oncogene protein akt><rac protein kinase><recruit><related to A and C-protein><resolutions><scRNA sequencing><scRNA-seq><sensor><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stroked><strokes><survival outcome><therapeutic target><thrombotic disease><thrombotic disorder><tool><transcriptional profiling><translation><unstable plaque><uptake><white adipose tissue><yellow adipose tissue>

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Peng Yao

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$497,488

FY 2026

Project Title

uORF-mediated Translational Control of Cardiac Transcription Factor Expression

Grant Number:

5R01HL164584-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Short peptide-encoding sequences in the 5' untranslated region of messenger ribonucleic acids (mRNA), called upstream open reading frames (uORFs), are widespread in ~50% of human mRNAs. Translating these uORF sequences reduces the protein output of an mRNA main open reading frame (mORF). Our bioinfo...

Research Terms

<5' Untranslated Regions><5'UTR><Animals><Antisense Agent><Antisense Oligonucleotides><Assay><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biochemical><Bioinformatics><Biological><Biological Assay><Biology><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiomyopathies><Cas nuclease technology><Cell Body><Cell Culture System><Cells><Chemistry><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Data Analyses><Data Analysis><Data Bases><Databases><Development><Disease Progression><Double-Stranded RNA><Elements><Exhibits><GATA binding protein 4><GATA4><GATA4 gene><GATA4 transcription factor><Gene Action Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><General Transcription Factor Gene><General Transcription Factors><Genetic><Heart><Heart Diseases><Heart Hypertrophy><Heart Muscle Cells><Heart failure><Heart myocyte><Homeostasis><Human><Hypertrophy><Initiation Codon><Initiator Codon><Intervention><KI mice><Knock-in Mouse><Left><Mediating><Mice><Mice Mammals><Modality><Modeling><Modern Man><Molecular><Morbidity><Murine><Mus><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><Non-Polyadenylated RNA><ORFs><Open Reading Frames><Output><Pathogenicity><Pathologic><Peptides><Phenotype><Physiological Homeostasis><Physiology><Preventative intervention><Protein Biosynthesis><Protein Coding Region><Proteins><RNA><RNA Gene Products><RNA Helicase><RNA based therapeutics><RNA based therapy><RNA therapy><Regulation><Repression><Ribo-seq><Ribonucleic Acid><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Role><Specificity><Start Codon><Stress><Structure><Technology><Therapeutic Intervention><Trans-Acting Factors><Trans-Activators><Transactivators><Transcript><Transcription Factor Proto-Oncogene><Transcription factor genes><Translating><Translational Inhibition><Translational Repression><Translations><United States><antisense oligo><aorta constriction><biologic><cardiac failure><cardiac function><cardiac hypertrophy><cardiomyocyte><data base><data interpretation><design><designing><developmental><dsRNA><function of the heart><genome editing><genomic editing><hESC><heart disorder><heart function><human ES cell><human ESC><human disease><human embryonic stem cell><innovate><innovation><innovative><insight><intervention for prevention><intervention therapy><knockin mice><loss of function><mRNA Leader Sequences><mortality><mouse model><murine model><mutant><myocardium disease><myocardium disorder><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><pressure><prevention intervention><preventional intervention strategy><preventive intervention><protein expression><protein synthesis><ribosome footprint profiling><ribosome profiling><social role><synergism><therapeutic RNA><transcription factor><translation>

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Beth A Weaver

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$469,883

FY 2026

Project Title

Non-canonical roles of Mitotic Arrest Deficient 1 (Mad1) in tumor promotion

Grant Number:

5R01CA270133-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Breast cancer is the most commonly diagnosed malignancy in women worldwide. Mitotic Arrest Deficient 1 (Mad1) is commonly upregulated in breast cancer where it serves as a marker of poor prognosis, and upregulation of Mad1 is sufficient for tumorigenesis in orthotopic breast cancer models. Mad1 was ...

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Jason A. Hanna

PURDUE UNIVERSITY, WEST LAFAYETTE, IN

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$437,654

FY 2026

Project Title

Dissecting the role of tumor suppressing microRNAs in angiosarcoma

Grant Number:

1R01CA299902-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/19/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Angiosarcomas are aggressive soft tissue sarcomas arising in endothelial cells with a poor prognosis and inadequate treatment options. Due to the rarity of the disease, there are limited resources for studying angiosarcoma and therefore little progress in identifying novel t...

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Daniel A. Haber

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$420,000

FY 2026

Project Title

Modeling Metastasis and Acquired Drug Resistance Using Circulating Tumor Cells

Grant Number:

5R01CA129933-19

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2008

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Advanced hormone receptor positive (HR+) breast cancers, the most common subtype, are initially responsive to multiple endocrine interventions, but they ultimately develop drug resistance. Circulating tumor cells (CTCs) underlie the blood-borne metastatic spread of cancer, and they a...

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Ricardo Mouro Pinto

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$412,058

FY 2026

Project Title

Somatic Repeat Expansions as a Therapeutic Target for Trinucleotide Repeat Disorders

Grant Number:

5R01NS126420-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Huntington’s disease (HD) and Friedreich ataxia (FA) are rare neurodegenerative diseases caused by expanded trinucleotide repeats (CAG and GAA, respectively) in the HTT and FXN genes, respectively, with larger alleles being associated with earlier disease onset and more severe clinical phe...

Research Terms

<0-11 years old><Address><Affect><Alleles><Allelomorphs><Antisense Agent><Antisense Oligonucleotides><Biological Markers><Biopsy><Body Tissues><Brain><Brain Nervous System><CAG repeat><CAG trinucleotide repeat><CRISPR><CRISPR based therapeutics><CRISPR based treatment><CRISPR therapeutics><CRISPR treatment><CRISPR-Cas based therapeutics><CRISPR-based disease therapeutics><CRISPR-based therapy><CRISPR/Cas system><CRISPR/Cas therapeutics><CRISPR/Cas9 therapeutics><CRISPR/Cas9 therapy><CRISPR/Cas9 treatment><CRISPR/Cas9-based therapy><Candidate Disease Gene><Candidate Gene><Cas9 based therapeutics><Cell Body><Cell model><Cells><Cellular model><Child><Child Youth><Children (0-21)><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats based therapeutics><Clustered Regularly Interspaced Short Palindromic Repeats therapeutics><Corpus Striatum><Corpus striatum structure><DNA Nicking Enzyme><DNA Repair Gene><DNA Repair Pathway><DNA Repeat Expansion><DNA mutation><DNA repair protein><Degenerative Neurologic Disorders><Development><Disease><Disease Progression><Disorder><Dorsal Root Ganglia><Drug Targeting><Encephalon><Endonuclease I><Exhibits><Expanded DNA Repeat><Fibroblasts><Freidreich's Ataxia><Friedreich Ataxia><Friedreich Disease><Friedreich Spinocerebellar Ataxia><Friedreich's Familial Ataxia><Friedreich's Hereditary Ataxia><Friedreich's Hereditary Spinal Ataxia><Friedreich's tabes><GWA study><GWAS><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Heart><Hereditary Spinal Sclerosis><Human><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><Investigation><Knock-out><Knockout><Knowledge><Length><Liver><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Methodology><Methods><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Mutation><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuromuscular Diseases><Neuron Degeneration><Neurons><Nickase><Oligo><Oligonucleotides><Onset of illness><Parents><Pathogenicity><Pathway interactions><Patients><Phenotype><Process><RNA Splicing><Reagent><Reporting><Research><Role><Sampling><Spinal Ganglia><Splicing><Striate Body><Striatum><System><Testing><Therapeutic><Therapeutic Intervention><Time><Tissues><Translating><Trinucleotide Repeat Expansion><Trinucleotide Repeats><Triplet Repeats><Validation><antisense oligo><base editor><bio-markers><biologic marker><biomarker><candidate validation><clinical phenotype><codon reiteration><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><disease onset><disorder onset><dorsal root ganglion><effective therapy><effective treatment><efficacy testing><endonuclease><experiment><experimental research><experimental study><experiments><family ataxia><fecal sample><genome mutation><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><hepatic body system><hepatic organ system><in vivo><insight><intergenerational><intervention therapy><kids><long read seq><long-read sequencing><long-read transcript sequencing><minimally invasive><monogenic disease><monogenic disorder><mouse model><murine model><myoneural disorder><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuromuscular degenerative disorder><neuromuscular disorder><neuronal><neuronal degeneration><new approaches><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel approaches><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><oligos><parent><pathway><potential biological marker><potential biomarker><promoter><promotor><single-gene disease><single-gene disorder><social role><stool sample><stool specimen><striatal><therapeutic target><tool><validations><whole genome association analysis><whole genome association study><youngster>

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Tingting Yang

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$411,250

FY 2026

Project Title

Interacting Partners of Bestrophin Channels

Grant Number:

5R35GM149252-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract The bestrophin proteins are a family of Ca2+-activated anion channels widely distributed from bacteria to mammals, with representatives in most metazoans including four in humans (Best1-4). They open in response to increases of intracellular Ca2+ to mediate the passive flow...

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Li Jia

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$409,463

FY 2026

Project Title

MMS22L loss and PARP inhibition in prostate cancer

Grant Number:

5R01CA279410-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Metastatic castration-resistant prostate cancer (mCRPC) is an incurable disease that is expected to account for ~ 34,500 deaths each year in the United States. Therapeutic options are limited for mCRPC patients that extend life. There is an urgent need for developing novel targeted therapi...

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PETER J. ESPENSHADE

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$409,375

FY 2026

Project Title

Regulation of Membrane Lipid Homeostasis

Grant Number:

5R35GM149312-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The lipid composition of cell membranes controls bilayer permeability and fluidity as well as the folding and activity of integral membrane proteins, which comprise ~30% of the human proteome. Consequently, the lipid composition of membranes is subject to tight homeostatic control. O...

Research Terms

<21+ years old><Address><Adult><Adult Human><Autoregulation><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Function><Cell Membrane Lipids><Cell Physiology><Cell Process><Cell membrane><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular biology><Cholesterol><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cytoplasmic Membrane><Endocytosis><Fatty Acids><Genes><Genetic><Homeostasis><Human><Hypercholesteremia><Integral Membrane Protein><Intervention><Intrinsic Membrane Protein><LDL><LDL Lipoproteins><LDL Receptors><LDLR gene><Learning><Lipid Trafficking><Lipids><Lipoprotein LDL Receptors><Low Density Lipoprotein Receptor><Low-Density Lipoproteins><Mammalian Cell><Membrane><Membrane Biology><Membrane Lipids><Modern Man><Pathway interactions><Permeability><Physiological Homeostasis><Plasma Membrane><Proteome><Regulation><Research><Subcellular Process><Transmembrane Protein><Transmembrane Protein Gene><United States><adulthood><beta-Lipoproteins><cell biology><fluidity><forward genetics><heart disease prevention><heart disorder prevention><high blood cholesterol><hypercholesterolemia><lipid transport><membrane structure><model organism><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><plasmalemma><prevent heart disease><receptor function>

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Yanlin He

LSU PENNINGTON BIOMEDICAL RESEARCH CTR, BATON ROUGE, LA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$397,707

FY 2026

Project Title

GABA neurons in the ventromedial hypothalamus contribute to the counterregulatory response

Grant Number:

5R01DK129548-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Glucose is the primary fuel in the brain. Glucose-sensing neurons in the brain respond to glucose fall by altering their firing activities, which trigger the counterregulatory responses to prevent severe hypoglycemia. The ventromedial hypothalamus (VMH) is a critical component of neu...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD4BP protein><Ad4-binding protein><Address><Aminalon><Aminalone><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Animals><Arcuate Nucleus><Blood Glucose><Blood Sugar><Brain><Brain Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Calcium><Calcium Channel><Calcium Channel Antagonist Receptor><Calcium Channel Blocker Receptors><Calcium Ion Channels><Cas nuclease technology><Clampings><Closure by clamp><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><D-Glucose><DNA><Data><Deoxyribonucleic Acid><Development><Dextrose><ERalpha><ERα><ESR1><ESR1 gene><Electrophysiology><Electrophysiology (science)><Encephalon><Endocrine Gland Secretion><Equilibrium><Estradiol Receptor alpha><Estradiol Receptor α><Estrogen Receptor 1><Estrogen Receptor alpha><Estrogen Receptor α><Event><FTZF1 protein><Failure><Fiber><Fushi tarazu factor homolog 1><GABA><Genes><Genetic><Glucose><Glutamates><Hormones><Hyperinsulinemia><Hyperinsulinism><Hypoglycemia><Hypothalamic structure><Hypothalamus><Impairment><Infundibular Nucleus><Ion Channel><Ionic Channels><L-Glutamate><Lateral><Life><Maps><Medial><Mediating><Mediator><Membrane Channels><Mice><Mice Mammals><Modeling><Molecular><Molecular Target><Monitor><Murine><Mus><NR3A1><NR5A1 protein><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Paraventricular Nucleus of Thalamus><Paraventricular Thalamic Nucleus><Photometry><Physiologic><Physiological><Play><Population><Property><Reporting><Role><SF 1><SF-1 transcription factor><SF1><Slice><Structure of nucleus infundibularis hypothalami><Structure of paraventricular nucleus of thalamus><Subgroup><Substantia Nigra><Substantia nigra structure><Testing><Therapeutic Hormone><VDCC><VGAT transporter><Voltage-Dependent Calcium Channels><Work><adrenal 4 binding protein><amygdaloid nuclear complex><balance><balance function><blood glucose regulation><counterregulation><developmental><diabetic><diabetic patient><electrophysiological><falls><gamma-Aminobutyric Acid><glucose control><glucose homeostasis><glucose regulation><glutamatergic><glycemic control><hypoglycemic><hypoglycemic episodes><hypothalamic><in vivo><neural><neural circuit><neural circuitry><neural network><neurochemical><neurochemistry><neurocircuitry><neuronal><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><nuclear receptor 5A1 protein><optogenetics><patch sequencing><patch-seq><patchseq><prevent><preventing><response><social role><steroid hormone receptor Ad4BP><steroidogenic factor 1><synaptic circuit><synaptic circuitry><transcription factor sf1><type 1 diabetic><type I diabetic><ventromedial hypothalamic nucleus><vesicular GABA transporter><voltage><γ-Aminobutyric Acid>

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Daniel John Siegwart

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$391,721

FY 2026

Project Title

Multiplexed nanoparticle delivery to increase CRISPR/Cas gene editing for enhanced cancer therapy

Grant Number:

5R01CA269787-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The programmable CRISPR/Cas gene editing system has great potential for cancer treatment due to the ability to precisely inactivate or repair cancer-related genes. However, delivery of CRISPR to solid tumors for efficient cancer therapy remains limited by the uniquely stiff and fibro...

Research Terms

<3D cell culture><3D culture><Affect><Antibodies><Applications Grants><B7-H1><Biological Markers><Body Tissues><Brain><Brain Nervous System><CD274><CRISPR><CRISPR/Cas system><Cancer Model><Cancer Treatment><CancerModel><Cancers><Cell Body><Cell-Extracellular Matrix><Cells><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Coupled><Data><ECM><Encapsulated><Encephalon><Endocytosis><Exhibits><Extracellular Matrix><Focal Adhesion Kinase 1><Formulation><Future><GEM model><GEMM model><Gene Inactivation><Gene Proteins><Gene Silencing><Generalized Growth><Genes><Genetic Enhancement><Genetic Suppression><Genetically Engineered Mouse><Grant Proposals><Growth><Hepatic Cancer><Hepatocarcinoma><Hepatocarcinoma model><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Immune infiltrates><Intravenous><Kinetics><Lipids><Liver><Liver Cells Carcinoma><Lung><Lung Respiratory System><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of liver><Malignant neoplasm of lung><Measures><Mechanics><Mediating><Messenger RNA><Mice><Mice Mammals><Modeling><Modification><Murine><Mus><Muscle><Muscle Tissue><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><Nucleic Acids><Organ><Outcome><PD-L1><PDL-1><PTK2 Protein Tyrosine Kinase 2><Pathway interactions><Penetration><Primary carcinoma of the liver cells><Programmed Cell Death 1 Ligand 1><Programmed Death Ligand 1><Protein Gene Products><Proteins><Pulmonary Cancer><Pulmonary malignant Neoplasm><Series><Short interfering RNA><Single-Stranded DNA><Solid Neoplasm><Solid Tumor><Spleen><Spleen Reticuloendothelial System><System><Therapeutic><Therapeutic Gene Editing><Tissue Growth><Tissues><Toxic effect><Toxicities><Treatment Efficacy><Tropism><Tumor Burden><Tumor Cell><Tumor Load><Tumor Tissue><Work><anti-cancer immunotherapy><anti-cancer therapy><anticancer immunotherapy><bio-markers><biologic marker><biomarker><cancer immunotherapy><cancer microenvironment><cancer progression><cancer therapy><cancer-directed therapy><deliver mRNA><deliver messenger RNA><delivery system for mRNA><design><designing><endogenous substrate pp120><focal adhesion kinase><focal adhesion protein tyrosine kinase><focal adhesion-associated protein tyrosine kinase pp125FAK><gene corrected><gene correction><gene editing platform><gene editing system><gene editing technology><gene editing tools><gene repair><gene-editing therapy><gene-editing toolkit><genetically engineered mouse model><genetically engineered murine model><genome editing><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genomic correction><genomic editing><hepatic body system><hepatic organ system><hepatocellular carcinoma cancer model><hepatocellular carcinoma model><immune cell infiltrate><immune-based cancer therapies><immunotherapy for cancer><immunotherapy of cancer><improved><in vivo><innovate><innovation><innovative><intervention efficacy><intravenous administration><knock-down><knockdown><lipid based nanoparticle><lipid nanoparticle><liver cancer><liver cancer model><liver carcinoma><liver malignancy><lung cancer><lung cancer cell><mRNA><mRNA delivery><malignancy><malignant liver tumor><mechanic><mechanical><mechanical force><mechanical properties><messenger RNA delivery><muscular><nano particle><nano particle delivery><nano-sized particle><nanoparticle><nanoparticle delivered><nanoparticle delivery><nanosized particle><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><nucleic acid delivery><ontogeny><pathway><programmed cell death ligand 1><programmed cell death protein ligand 1><protein death-ligand 1><repair><repaired><siRNA><spheroids><ssDNA><synergism><therapeutic editing><therapeutic efficacy><therapeutic genome editing><therapy efficacy><three dimensional cell culture><transcriptional silencing><tumor><tumor microenvironment><tumor progression><uptake>

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Anjon Audhya

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$375,430

FY 2026

Project Title

Mechanisms Underlying Axonopathy in Hereditary Spastic Paraplegia

Grant Number:

5R01NS124165-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Axonal degeneration within the corticospinal tract leads to several neurological diseases, including hereditary spastic paraplegias (HSPs), which are a clinically and genetically heterogeneous group of gait disorders characterized by poor balance, spasticity, and progressive muscle ...

Research Terms

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Dino Di Carlo

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$363,766

FY 2026

Project Title

Engineering Yeast towards High Titer Production of Monoterpene Indole Alkaloid Natural Products

Grant Number:

5R01AT010001-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2018

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Reconstruction of plant natural product pathways in genetically well-characterized microbial organisms such as Saccharomyces cerevisiae is a sustainable and scalable method of producing high value pharmaceutical compounds. The family of monoterpene indole alkaloids (MIAs) represent a divers...

Research Terms

<12-Methoxyibogamine><12-methoxy-ibogamine><Achievement><Achievement Attainment><Anabolism><Baker's Yeast><Behavior><Biologic Models><Biological><Biological Models><Biotransformation><Botanical natural products><Brewer's Yeast><CRISPR><CRISPR activation><CRISPR activator><CRISPR based activation><CRISPR gene activation><CRISPR interference><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-dCAS9 Activator><CRISPR-dCas9-mediated repression><CRISPR-mediated transcriptional activation><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/Cas system><CRISPR/dCas9 activation><CRISPR/dCas9 interference><CRISPR/dCas9-based transcriptional activation><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRa><CRISPRi><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Chemicals><Chemistry><Cloning><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats interference><Collaborations><Collection><Complex><Data><Derivation><Derivation procedure><Directed Molecular Evolution><Disease><Disorder><Drugs><Encapsulated><Engineering><Enzymatic Biochemistry><Enzyme Gene><Enzymes><Enzymology><Evaluation><Family><Fluorescence><Generalized Growth><Genes><Genetic Screening><Genetics-Mutagenesis><Genome><Grant><Growth><High Throughput Assay><Hydrogels><Ibogaine><Indole Alkaloids><Investigation><Letters><Liquid substance><Maintenance><Medication><Metabolic><Metabolic Biotransformation><Methods><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Microfluidics><Model System><Monoterpenes><Monoterpenoids><Mutagenesis><Mutagenesis Molecular Biology><Natural Products><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Organism><Pathway interactions><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phytochemical><Plant alkaloid><Plant derived metabolites><Plant natural product><Plant-based Natural Product><Plant-derived natural products><Plants><Position><Positioning Attribute><Process><Production><Psychoactive Agents><Psychoactive Compound><Psychoactive Drugs><Psychopharmaceuticals><Psychotropic Drugs><R-Series Research Projects><R01 Mechanism><R01 Program><Reporter><Reporting><Research Grants><Research Project Grants><Research Projects><S cerevisiae><S. cerevisiae><Saccharomyces cerevisiae><Signaling Molecule><Sorting><Source><System><Technology><Therapeutic><Tissue Growth><Vinblastine><Vincaleucoblastine><Vincaleukoblastine><Yeasts><activating CRISPR technology><addiction><addictive disorder><biologic><bionano technology><bionanotechnology><biosynthesis><cell sorting><directed evolution><drug/agent><fluid><genome scale><genome wide screen><genome-wide><genomewide><glucosidase><healthy lifestyle><high throughput screening><improved><interest><isovincoside><liquid><living system><microbial><microbial host><microfluidic chip><mutant><nanobiotechnology><naturally occurring product><new approaches><novel approaches><novel strategies><novel strategy><ontogeny><opioid addiction><opioid dependence><opioid dependent><particle><pathway><pharmaceutical><pharmacologic><plant compound><plant derived compound><plant metabolites><promoter><promotor><prophylactic><reconstitute><reconstitution><reconstruction><repressing CRISPR-dCas9 system><screening><screenings><strictosidine><success><synthetic biology><tool><µfluidic>

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Yi Tang

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$363,766

FY 2026

Project Title

Engineering Yeast towards High Titer Production of Monoterpene Indole Alkaloid Natural Products

Grant Number:

5R01AT010001-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2018

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Reconstruction of plant natural product pathways in genetically well-characterized microbial organisms such as Saccharomyces cerevisiae is a sustainable and scalable method of producing high value pharmaceutical compounds. The family of monoterpene indole alkaloids (MIAs) represent a divers...

Research Terms

<12-Methoxyibogamine><12-methoxy-ibogamine><Achievement><Achievement Attainment><Anabolism><Baker's Yeast><Behavior><Biologic Models><Biological><Biological Models><Biotransformation><Botanical natural products><Brewer's Yeast><CRISPR><CRISPR activation><CRISPR activator><CRISPR based activation><CRISPR gene activation><CRISPR interference><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-dCAS9 Activator><CRISPR-dCas9-mediated repression><CRISPR-mediated transcriptional activation><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/Cas system><CRISPR/dCas9 activation><CRISPR/dCas9 interference><CRISPR/dCas9-based transcriptional activation><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRa><CRISPRi><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Chemicals><Chemistry><Cloning><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats interference><Collaborations><Collection><Complex><Data><Derivation><Derivation procedure><Directed Molecular Evolution><Disease><Disorder><Drugs><Encapsulated><Engineering><Enzymatic Biochemistry><Enzyme Gene><Enzymes><Enzymology><Evaluation><Family><Fluorescence><Generalized Growth><Genes><Genetic Screening><Genetics-Mutagenesis><Genome><Grant><Growth><High Throughput Assay><Hydrogels><Ibogaine><Indole Alkaloids><Investigation><Letters><Liquid substance><Maintenance><Medication><Metabolic><Metabolic Biotransformation><Methods><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Microfluidics><Model System><Monoterpenes><Monoterpenoids><Mutagenesis><Mutagenesis Molecular Biology><Natural Products><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Organism><Pathway interactions><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phytochemical><Plant alkaloid><Plant derived metabolites><Plant natural product><Plant-based Natural Product><Plant-derived natural products><Plants><Position><Positioning Attribute><Process><Production><Psychoactive Agents><Psychoactive Compound><Psychoactive Drugs><Psychopharmaceuticals><Psychotropic Drugs><R-Series Research Projects><R01 Mechanism><R01 Program><Reporter><Reporting><Research Grants><Research Project Grants><Research Projects><S cerevisiae><S. cerevisiae><Saccharomyces cerevisiae><Signaling Molecule><Sorting><Source><System><Technology><Therapeutic><Tissue Growth><Vinblastine><Vincaleucoblastine><Vincaleukoblastine><Yeasts><activating CRISPR technology><addiction><addictive disorder><biologic><bionano technology><bionanotechnology><biosynthesis><cell sorting><directed evolution><drug/agent><fluid><genome scale><genome wide screen><genome-wide><genomewide><glucosidase><healthy lifestyle><high throughput screening><improved><interest><isovincoside><liquid><living system><microbial><microbial host><microfluidic chip><mutant><nanobiotechnology><naturally occurring product><new approaches><novel approaches><novel strategies><novel strategy><ontogeny><opioid addiction><opioid dependence><opioid dependent><particle><pathway><pharmaceutical><pharmacologic><plant compound><plant derived compound><plant metabolites><promoter><promotor><prophylactic><reconstitute><reconstitution><reconstruction><repressing CRISPR-dCas9 system><screening><screenings><strictosidine><success><synthetic biology><tool><µfluidic>

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Rintaro Hashizume

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$360,285

FY 2026

Project Title

Targeting Transcriptional Elongation in Pediatric Glioma

Grant Number:

5R01NS126513-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT - Diffuse intrinsic pontine glioma (DIPG) is one of the most devastating pediatric cancers. Numerous clinical trials in decades, involving different combinations of chemotherapeutic agents and radiation, have been ineffective in treating DIPG. The identification of efficacio...

Research Terms

<0-11 years old><Acetylation><Animals><Astrocytes><Astrocytus><Astroglia><Biological><Brain><Brain Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Patient><Cas nuclease technology><Cell Body><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Characteristics><Child><Child Youth><Childhood Brain Neoplasm><Childhood Brain Tumor><Childhood Cancers><Childhood Glioma><Children (0-21)><Chromatin><Clinical Evaluation><Clinical Testing><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Combined Modality Therapy><Complex><DIPG><DNA Damage><DNA Damage Repair><DNA Injury><DNA Repair><DNA Repair Pathway><DNA mutation><DNA-Dependent RNA Polymerase II><Data><Dependence><Development><Diagnosis><Diffuse intrinsic pontine glioma><Disease><Disorder><Drug Kinetics><Elongation Factor><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Expression Profiling><Foundations><Gene Alteration><Gene Expression><Gene Mutation><Gene Transcription><Generalized Growth><Genes><Genetic><Genetic Change><Genetic Screening><Genetic Transcription><Genetic defect><Genetic mutation><Goals><Growth><Heterograft><Heterologous Transplantation><Histone H3><Histones><Human><In Vitro><Individual><Knock-out><Knockout><Knowledge><L-Lysine><Lysine><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant childhood cancer><Mediating><Methionine><Methylation><Mission><Modeling><Modern Man><Modification><Molecular><Multimodal Therapy><Multimodal Treatment><Mutation><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nature><Nervous System><Nervous System Diseases><Nervous System Disorder><Neurologic Body System><Neurologic Disorders><Neurologic Organ System><Neurological Disorders><Non-Polyadenylated RNA><Oncogenic><Orphan Disease><P-TEFb><PDX model><Pathogenesis><Patient derived xenograft><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pediatric Glioma><Pediatric high-grade glioma><Peptide Domain><Pharmacokinetics><Polymerase><Positive Transcription Elongation Factor B><Positive Transcriptional Elongation Factor B><Property><Protein Domains><Public Health><RNA><RNA Expression><RNA Gene Products><RNA Polymerase B><RNA Polymerase II><RNA Seq><RNA sequencing><RNAseq><Radiation><Radiation Sensitivity><Radiation Tolerance><Radiation enhancer><Radiation therapy><Radiosensitivity><Radiotherapeutics><Radiotherapy><Rare Diseases><Rare Disorder><Research><Resistance><Ribonucleic Acid><SEQ-AN><Sequence Analyses><Sequence Analysis><Tertiary Protein Structure><Testing><Therapeutic><Therapeutic Intervention><Tissue Growth><Toxic effect><Toxicities><Transcription><Transcription Activation><Transcription Elongation><Transcription Initiation><Transcriptional Activation><Treatment outcome><Tumor Cell><Unscheduled DNA Synthesis><Xenograft><Xenograft procedure><Xenotransplantation><astrocytic glia><biologic><bioluminescence imaging><bioluminescent imaging><cancer in a child><cancer in children><cancer progression><chemotherapeutic agent><chemotherapeutic compounds><chemotherapeutic drugs><chemotherapeutic medications><child with cancer><childhood malignancy><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><clinical practice><clinical test><combination therapy><combinatorial><combined modality treatment><combined treatment><developmental><early clinical trial><early phase clinical trial><effective therapy><effective treatment><epigenetically><experiment><experimental research><experimental study><experiments><gene defect><genome mutation><genome scale><genome-wide><genomewide><global gene expression><global transcription profile><improved><in vivo><inhibitor><inhibitor drug><inhibitor therapeutic><inhibitor therapy><intervention therapy><kids><knock-down><knockdown><multi-modal therapy><multi-modal treatment><mutant><mutant allele><neoplasm progression><neoplastic cell><neoplastic progression><neurological disease><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><ontogeny><orphan disorder><patient derived xenograft model><patient oriented outcomes><patient screening><pediatric brain neoplasm><pediatric brain tumor><pediatric cancer><pediatric malignancy><pharmacologic><prevent><preventing><protein H(3)><protein H3><radiation enhancing agent><radiation treatment><radio-sensitivity><radiosensitive><research clinical testing><resistance to therapy><resistant><resistant to therapy><shRNA><short hairpin RNA><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tat-Associated Kinase><therapeutic resistance><therapeutic target><therapeutically effective><therapy resistant><transcriptional reprogramming><transcriptome><transcriptome sequencing><transcriptomic sequencing><treatment resistance><treatment with radiation><tumor><tumor growth><tumor progression><xeno-transplant><xeno-transplantation><youngster>

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Alejandro Chavez

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$955,050

FY 2026

Project Title

Methods to Rapidly Explore Combinatorial Diversity and their Application to CRISPR-Cas9 Systems

Grant Number:

4DP2NS131566-03

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT For decades, biologists have taken parts from disparate proteins and fused them in various combinations to create engineered variants with user defined properties. Despite the success of many of the generated tools (e.g. chimeric antigen receptors and enhanced CRISPR variants) the methods b...

Research Terms

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Michael Lee Stitzel

JACKSON LABORATORY, BAR HARBOR, ME

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$891,736

FY 2026

Project Title

Dissecting cell type-specific genetic programming of islet (dys)function in type 2 diabetes

Grant Number:

5R01DK118011-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/3/2020

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Type 2 diabetes (T2D) is a complex genetic disease that occurs when pancreatic islets cannot secrete sufficient insulin to overcome peripheral tissue insulin resistance. Genome-wide association studies (GWAS) have identified DNA sequence variants associated with T2D (T2D SNVs) in >60...

Research Terms

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Chun-Jun Guo

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$828,994

FY 2026

Project Title

Investigation of gut microbiota metabolite-mediated transkingdom interactions with fungi

Grant Number:

5R01AI178683-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The human intestinal tract supports a complex microbial environment consisting of bacterial (or microbiota) and fungal (or mycobiota) constituents. Although the role of each of these communities has been a subject of multiple studies, the role of transkingdom interactions between fu...

Research Terms

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ILIYAN Dimitrov ILIEV

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$828,994

FY 2026

Project Title

Investigation of gut microbiota metabolite-mediated transkingdom interactions with fungi

Grant Number:

5R01AI178683-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The human intestinal tract supports a complex microbial environment consisting of bacterial (or microbiota) and fungal (or mycobiota) constituents. Although the role of each of these communities has been a subject of multiple studies, the role of transkingdom interactions between fu...

Research Terms

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Laurence Alexandra Florens

UNIVERSITY OF CALIFORNIA RIVERSIDE, RIVERSIDE, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$768,340

FY 2026

Project Title

Deciphering the Role of Non-Coding RNAs in Gene Regulation

Grant Number:

5R01AI188634-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract: Nearly half of the world’s population lives in countries where malaria is endemic. Plasmodium falciparum, the causative agent of the most severe form of human malaria, is responsible for 95% of malaria deaths worldwide. The main goal of this project is to identify the molecular factors tha...

Research Terms

<3-D><3-Dimensional><3C-based approach><3C-based assay><3C-based method><3C-based strategy><3C-based technique><3C-based technology><3D><Address><Affect><Antigen Variation><Antigenic Variability><Antigenic Variation><Architecture><Biological><Biological Function><Biological Process><Biology><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Nucleus><Cessation of life><Chars><Chromatin><Chromatin Structure><Chromosomal Organization><Chromosomal Structure><Chromosome Organization><Chromosome Structures><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Complex><Country><Culicidae><DNA><Data><Death><Deoxyribonucleic Acid><Development><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Eukaryotic Cell><Functional RNA><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic><Genetic Transcription><Genome><Genomic Segment><Genomics><Goals><Heterochromatin><Hi-C><Human><Immune Evasion><Infection><Infectious Agent><Knowledge><Laboratories><Lead><Life Cycle><Life Cycle Stages><Maintenance><Malaria><Methodology><Modern Man><Molecular><Mosquitoes><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Nucleus><Outcomes Research><P. falciparum><P.falciparum><Paludism><Parasite Control><Parasites><Pattern><Pb element><Plasmodium><Plasmodium Infections><Plasmodium falciparum><Play><Population><Process><Proteins><RNA><RNA Expression><RNA Gene Products><Research><Ribonucleic Acid><Role><Salvelinus><Scientist><Sex Differentiation><Sexual Development><Site><Technology><Testing><Therapeutic><Transcript><Transcription><Transcriptional Control><Transcriptional Regulation><Transmission><Untranslated RNA><Virulence><Work><asexual><biologic><candidate selection><chromatin conformation capture><chromosome capture><chromosome conformation capture><communicable disease transmission><deep sequencing><design><designing><developmental><disease transmission><epigenetic regulation><epigenetically><experiment><experimental research><experimental study><experiments><genetic information><genome scale><genome segment><genome wide analysis><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><genomic region><heavy metal Pb><heavy metal lead><immune evasive><infectious disease transmission><infectious organism><insight><life course><multidisciplinary><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><noncoding><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><parasite genome><programs><promoter><promotor><sex development><sex-differentiation><sexual differentiation><social role><three dimensional><transmission process>

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Karine Gaelle Le Roch

UNIVERSITY OF CALIFORNIA RIVERSIDE, RIVERSIDE, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$768,340

FY 2026

Project Title

Deciphering the Role of Non-Coding RNAs in Gene Regulation

Grant Number:

5R01AI188634-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract: Nearly half of the world’s population lives in countries where malaria is endemic. Plasmodium falciparum, the causative agent of the most severe form of human malaria, is responsible for 95% of malaria deaths worldwide. The main goal of this project is to identify the molecular factors tha...

Research Terms

<3-D><3-Dimensional><3C-based approach><3C-based assay><3C-based method><3C-based strategy><3C-based technique><3C-based technology><3D><Address><Affect><Antigen Variation><Antigenic Variability><Antigenic Variation><Architecture><Biological><Biological Function><Biological Process><Biology><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Nucleus><Cessation of life><Chars><Chromatin><Chromatin Structure><Chromosomal Organization><Chromosomal Structure><Chromosome Organization><Chromosome Structures><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Complex><Country><Culicidae><DNA><Data><Death><Deoxyribonucleic Acid><Development><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Eukaryotic Cell><Functional RNA><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic><Genetic Transcription><Genome><Genomic Segment><Genomics><Goals><Heterochromatin><Hi-C><Human><Immune Evasion><Infection><Infectious Agent><Knowledge><Laboratories><Lead><Life Cycle><Life Cycle Stages><Maintenance><Malaria><Methodology><Modern Man><Molecular><Mosquitoes><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Nucleus><Outcomes Research><P. falciparum><P.falciparum><Paludism><Parasite Control><Parasites><Pattern><Pb element><Plasmodium><Plasmodium Infections><Plasmodium falciparum><Play><Population><Process><Proteins><RNA><RNA Expression><RNA Gene Products><Research><Ribonucleic Acid><Role><Salvelinus><Scientist><Sex Differentiation><Sexual Development><Site><Technology><Testing><Therapeutic><Transcript><Transcription><Transcriptional Control><Transcriptional Regulation><Transmission><Untranslated RNA><Virulence><Work><asexual><biologic><candidate selection><chromatin conformation capture><chromosome capture><chromosome conformation capture><communicable disease transmission><deep sequencing><design><designing><developmental><disease transmission><epigenetic regulation><epigenetically><experiment><experimental research><experimental study><experiments><genetic information><genome scale><genome segment><genome wide analysis><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><genomic region><heavy metal Pb><heavy metal lead><immune evasive><infectious disease transmission><infectious organism><insight><life course><multidisciplinary><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><noncoding><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><parasite genome><programs><promoter><promotor><sex development><sex-differentiation><sexual differentiation><social role><three dimensional><transmission process>

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Vasant Muralidharan

UNIVERSITY OF CALIFORNIA RIVERSIDE, RIVERSIDE, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$768,340

FY 2026

Project Title

Deciphering the Role of Non-Coding RNAs in Gene Regulation

Grant Number:

5R01AI188634-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract: Nearly half of the world’s population lives in countries where malaria is endemic. Plasmodium falciparum, the causative agent of the most severe form of human malaria, is responsible for 95% of malaria deaths worldwide. The main goal of this project is to identify the molecular factors tha...

Research Terms

<3-D><3-Dimensional><3C-based approach><3C-based assay><3C-based method><3C-based strategy><3C-based technique><3C-based technology><3D><Address><Affect><Antigen Variation><Antigenic Variability><Antigenic Variation><Architecture><Biological><Biological Function><Biological Process><Biology><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Nucleus><Cessation of life><Chars><Chromatin><Chromatin Structure><Chromosomal Organization><Chromosomal Structure><Chromosome Organization><Chromosome Structures><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Complex><Country><Culicidae><DNA><Data><Death><Deoxyribonucleic Acid><Development><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Eukaryotic Cell><Functional RNA><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic><Genetic Transcription><Genome><Genomic Segment><Genomics><Goals><Heterochromatin><Hi-C><Human><Immune Evasion><Infection><Infectious Agent><Knowledge><Laboratories><Lead><Life Cycle><Life Cycle Stages><Maintenance><Malaria><Methodology><Modern Man><Molecular><Mosquitoes><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Nucleus><Outcomes Research><P. falciparum><P.falciparum><Paludism><Parasite Control><Parasites><Pattern><Pb element><Plasmodium><Plasmodium Infections><Plasmodium falciparum><Play><Population><Process><Proteins><RNA><RNA Expression><RNA Gene Products><Research><Ribonucleic Acid><Role><Salvelinus><Scientist><Sex Differentiation><Sexual Development><Site><Technology><Testing><Therapeutic><Transcript><Transcription><Transcriptional Control><Transcriptional Regulation><Transmission><Untranslated RNA><Virulence><Work><asexual><biologic><candidate selection><chromatin conformation capture><chromosome capture><chromosome conformation capture><communicable disease transmission><deep sequencing><design><designing><developmental><disease transmission><epigenetic regulation><epigenetically><experiment><experimental research><experimental study><experiments><genetic information><genome scale><genome segment><genome wide analysis><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><genomic region><heavy metal Pb><heavy metal lead><immune evasive><infectious disease transmission><infectious organism><insight><life course><multidisciplinary><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><noncoding><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><parasite genome><programs><promoter><promotor><sex development><sex-differentiation><sexual differentiation><social role><three dimensional><transmission process>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

William Stafford Noble

UNIVERSITY OF CALIFORNIA RIVERSIDE, RIVERSIDE, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$768,340

FY 2026

Project Title

Deciphering the Role of Non-Coding RNAs in Gene Regulation

Grant Number:

5R01AI188634-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract: Nearly half of the world’s population lives in countries where malaria is endemic. Plasmodium falciparum, the causative agent of the most severe form of human malaria, is responsible for 95% of malaria deaths worldwide. The main goal of this project is to identify the molecular factors tha...

Research Terms

<3-D><3-Dimensional><3C-based approach><3C-based assay><3C-based method><3C-based strategy><3C-based technique><3C-based technology><3D><Address><Affect><Antigen Variation><Antigenic Variability><Antigenic Variation><Architecture><Biological><Biological Function><Biological Process><Biology><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Nucleus><Cessation of life><Chars><Chromatin><Chromatin Structure><Chromosomal Organization><Chromosomal Structure><Chromosome Organization><Chromosome Structures><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Complex><Country><Culicidae><DNA><Data><Death><Deoxyribonucleic Acid><Development><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Eukaryotic Cell><Functional RNA><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic><Genetic Transcription><Genome><Genomic Segment><Genomics><Goals><Heterochromatin><Hi-C><Human><Immune Evasion><Infection><Infectious Agent><Knowledge><Laboratories><Lead><Life Cycle><Life Cycle Stages><Maintenance><Malaria><Methodology><Modern Man><Molecular><Mosquitoes><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Nucleus><Outcomes Research><P. falciparum><P.falciparum><Paludism><Parasite Control><Parasites><Pattern><Pb element><Plasmodium><Plasmodium Infections><Plasmodium falciparum><Play><Population><Process><Proteins><RNA><RNA Expression><RNA Gene Products><Research><Ribonucleic Acid><Role><Salvelinus><Scientist><Sex Differentiation><Sexual Development><Site><Technology><Testing><Therapeutic><Transcript><Transcription><Transcriptional Control><Transcriptional Regulation><Transmission><Untranslated RNA><Virulence><Work><asexual><biologic><candidate selection><chromatin conformation capture><chromosome capture><chromosome conformation capture><communicable disease transmission><deep sequencing><design><designing><developmental><disease transmission><epigenetic regulation><epigenetically><experiment><experimental research><experimental study><experiments><genetic information><genome scale><genome segment><genome wide analysis><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><genomic region><heavy metal Pb><heavy metal lead><immune evasive><infectious disease transmission><infectious organism><insight><life course><multidisciplinary><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><noncoding><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><parasite genome><programs><promoter><promotor><sex development><sex-differentiation><sexual differentiation><social role><three dimensional><transmission process>

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Photini Sinnis

UNIVERSITY OF CALIFORNIA RIVERSIDE, RIVERSIDE, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$768,340

FY 2026

Project Title

Deciphering the Role of Non-Coding RNAs in Gene Regulation

Grant Number:

5R01AI188634-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract: Nearly half of the world’s population lives in countries where malaria is endemic. Plasmodium falciparum, the causative agent of the most severe form of human malaria, is responsible for 95% of malaria deaths worldwide. The main goal of this project is to identify the molecular factors tha...

Research Terms

<3-D><3-Dimensional><3C-based approach><3C-based assay><3C-based method><3C-based strategy><3C-based technique><3C-based technology><3D><Address><Affect><Antigen Variation><Antigenic Variability><Antigenic Variation><Architecture><Biological><Biological Function><Biological Process><Biology><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Nucleus><Cessation of life><Chars><Chromatin><Chromatin Structure><Chromosomal Organization><Chromosomal Structure><Chromosome Organization><Chromosome Structures><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Complex><Country><Culicidae><DNA><Data><Death><Deoxyribonucleic Acid><Development><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Eukaryotic Cell><Functional RNA><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic><Genetic Transcription><Genome><Genomic Segment><Genomics><Goals><Heterochromatin><Hi-C><Human><Immune Evasion><Infection><Infectious Agent><Knowledge><Laboratories><Lead><Life Cycle><Life Cycle Stages><Maintenance><Malaria><Methodology><Modern Man><Molecular><Mosquitoes><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Nucleus><Outcomes Research><P. falciparum><P.falciparum><Paludism><Parasite Control><Parasites><Pattern><Pb element><Plasmodium><Plasmodium Infections><Plasmodium falciparum><Play><Population><Process><Proteins><RNA><RNA Expression><RNA Gene Products><Research><Ribonucleic Acid><Role><Salvelinus><Scientist><Sex Differentiation><Sexual Development><Site><Technology><Testing><Therapeutic><Transcript><Transcription><Transcriptional Control><Transcriptional Regulation><Transmission><Untranslated RNA><Virulence><Work><asexual><biologic><candidate selection><chromatin conformation capture><chromosome capture><chromosome conformation capture><communicable disease transmission><deep sequencing><design><designing><developmental><disease transmission><epigenetic regulation><epigenetically><experiment><experimental research><experimental study><experiments><genetic information><genome scale><genome segment><genome wide analysis><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><genomic region><heavy metal Pb><heavy metal lead><immune evasive><infectious disease transmission><infectious organism><insight><life course><multidisciplinary><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><noncoding><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><parasite genome><programs><promoter><promotor><sex development><sex-differentiation><sexual differentiation><social role><three dimensional><transmission process>

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Varghese John

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$753,804

FY 2026

Project Title

Optimization and preclinical evaluation of brain permeant SE-CRISPR to edit ApoE4 after IV infusion in AD models

Grant Number:

5R01AG090773-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT This proposal is based on our successful SE-CRISPR editing of the APOE4 gene at the codon for amino acid 112 distinguishing it from APOE3 (1), in the brain E4-5XFAD AD model mice (2) by a single IV infusion of microfluidic synthetic exosome (SE)-encapsulated CRISPR sgRNA+CBE...

Research Terms

<21+ years old><AD brain><AD dementia><AD model><AD risk><AD risk factor><AD therapy><AD treatment><APOE e3><APOE e4><APOE-ε4><APOEε4><Address><Aducanumab><Adult><Adult Human><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's therapy><Alzheimers Dementia><Amino Acids><Ammon Horn><Amyloid><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Amyloidosis><Antibodies><Arginine><Astrocytes><Astrocytus><Astroglia><Astroprotein><Azides><Aβ><BBB crossing><BBB permeabilization><BBB permeable><BIIB037><Behavior><Behavioral><Benign><Binding Proteins><Biochemical><Biological Markers><Blood - brain barrier anatomy><Blood Plasma><Blood leukocyte><Blood-Brain Barrier><Body Tissues><Brain><Brain Nervous System><Brain region><CRISPR><CRISPR based therapeutics><CRISPR based treatment><CRISPR therapeutics><CRISPR treatment><CRISPR-Cas based therapeutics><CRISPR-based disease therapeutics><CRISPR-based therapy><CRISPR/Cas system><CRISPR/Cas therapeutics><CRISPR/Cas9 therapeutics><CRISPR/Cas9 therapy><CRISPR/Cas9 treatment><CRISPR/Cas9-based therapy><Cas9 based therapeutics><Cell Body><Cells><Chemistry><Chronic><Clinic><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats based therapeutics><Clustered Regularly Interspaced Short Palindromic Repeats therapeutics><Codon><Codon Nucleotides><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Collection><Common Rat Strains><Consensus><Cornu Ammonis><Cysteine><Cytosine><Data><Development><Diffusion><Disease><Disorder><Disturbance in cognition><Doctor of Medicine><Dose><ELISA><Encapsulated><Encephalon><Enzyme-Linked Immunosorbent Assay><Euthanasia><Evaluation><Female><Frequencies><GFA-Protein><GFAP><Genes><Genetic Diseases><Genetic predisposing factor><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Glycols><Goals><Guide RNA><Half-Cystine><Half-Life><Hb SS disease><HbSS disease><Hemato-Encephalic Barrier><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hepatic Disorder><Heterozygote><Hippocampus><Human><IV Infusion><Impaired cognition><In Vitro><Inflammation><Injections><Interphase Cell><Intravenous infusion procedures><Knock-in><L-Arginine><L-Cysteine><Label><Leukocytes><Leukocytes Reticuloendothelial System><Life><Ligand Binding Protein><Ligand Binding Protein Gene><Lipids><Liver><Liver diseases><M.D.><Macrogols><Marrow leukocyte><Measures><Memory><Memory Deficit><Memory impairment><Mercy Killing><Messenger RNA><Mice><Mice Mammals><Microfluidics><Modeling><Modern Man><Modification><Monitor><Murine><Mus><NGS Method><NGS system><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neuritic Plaques><Neurocyte><Neuron Degeneration><Neurons><Non-Polyadenylated RNA><Non-dividing Cell><Nondividing Cell><Nucleotides><Pathology><Penetrance><Peptides><Peripheral><Phase><Phenotype><Phosphatides><Phospholipids><Plasma><Plasma Enhancement><Plasma Proteins><Plasma Serum><Polyethylene Glycols><Polyethylene Oxide><Polyethyleneoxide><Polyoxyethylenes><Prealbumin><Primary Senile Degenerative Dementia><Proalbumin><Production><Protein Binding><Proteins><RNA><RNA Gene Products><Rat><Rats Mammals><Rattus><Regimen><Resting Cell><Reticuloendothelial System, Serum, Plasma><Ribonucleic Acid><Safety><Schedule><Senile Plaques><Sickle Cell Anemia><Siderophilin><Single Base Polymorphism><Single Nucleotide Polymorphism><Surface><Surrogate Markers><Tail><Tauopathies><Technology><Testing><Therapeutic><Tissues><Transferrin><Transgenic Mice><Translations><Transthyretin><Variant><Variation><Veins><White Blood Cells><White Cell><a beta peptide><abeta><aduhelm><adulthood><age associated effects><age effect><age related effects><aging effect><alzheimer model><alzheimer risk><aminoacid><amyloid beta><amyloid beta plaque><amyloid disease><amyloid-b plaque><amyloid-b protein><apo E-3><apo E-4><apo E3><apo E4><apo epsilon4><apoE epsilon 4><apoE-3><apoE-4><apoE3><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-3><apolipoprotein E-4><apolipoprotein E3><apolipoprotein E4><astrocytic glia><aβ plaques><base editing><beta amyloid fibril><bio-markers><biologic marker><biomarker><blood-brain barrier crossing><blood-brain barrier permeabilization><blood-brain barrier permeable><bloodbrain barrier><bloodbrain barrier crossing><bloodbrain barrier permeabilization><bloodbrain barrier permeable><bound protein><brain cell><brain parenchyma><brain tissue><cell type><clinical development><cognitive dysfunction><cognitive loss><cohort><cored plaque><developmental><diffuse plaque><diffused><diffuses><diffusing><diffusions><diol><dosage><enzyme linked immunoassay><exosome><gRNA><genetic condition><genetic disorder><genetic risk factor><hepatic body system><hepatic disease><hepatic organ system><hepatopathy><heterozygosity><hippocampal><impact of age><inflammation marker><inflammatory marker><influence of age><inherited factor><intravenous infusion><knockin><lipid based nanoparticle><lipid nanoparticle><liver disorder><mRNA><mRNA Expression><macromolecule><male><memory dysfunction><mouse model><murine model><nano vesicle><nanovesicle><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal><neuronal degeneration><neuropathologic tau><neuropathological tau><neurotoxic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next gen sequencing><next generation sequencing><nextgen sequencing><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><p-tau><p-τ><phospho-tau><phospho-τ><phosphorylated tau><post-translational modification of tau><posttranslational modification of tau><pre-clinical evaluation><preclinical evaluation><primary degenerative dementia><protein expression><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><single nucleotide variant><soluble amyloid precursor protein><surrogate bio-markers><surrogate biomarkers><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau phosphorylation><tau posttranslational modification><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic target><translation><translation strategy><translational approach><translational strategy><white blood cell><white blood corpuscle><work group><working group><µfluidic><τ phosphorylation><♀><♂>

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Alexander Marson

J. DAVID GLADSTONE INSTITUTES, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$749,187

FY 2026

Project Title

Decoding and reprogramming T cells through synthetic biology for cancer immunotherapy

Grant Number:

5R01CA276368-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Engineered T cell-based cancer therapies are a major advancement in cancer treatment; however the majority of cancers still do not respond to adoptive cellular therapy. We need to “design” new T cell therapies with increased potency, and we need to overcome cell dysfunction that occurs as T...

Research Terms

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Kole T Roybal

J. DAVID GLADSTONE INSTITUTES, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$749,187

FY 2026

Project Title

Decoding and reprogramming T cells through synthetic biology for cancer immunotherapy

Grant Number:

5R01CA276368-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Engineered T cell-based cancer therapies are a major advancement in cancer treatment; however the majority of cancers still do not respond to adoptive cellular therapy. We need to “design” new T cell therapies with increased potency, and we need to overcome cell dysfunction that occurs as T...

Research Terms

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Richard T Pomerantz

THOMAS JEFFERSON UNIVERSITY, PHILADELPHIA, PA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$741,972

FY 2026

Project Title

Novel Mechanisms and Regulation of Mammalian Double-Strand Break Repair

Grant Number:

5R35GM152198-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project summary. Cell proliferation under normal and adverse environmental conditions depends on multiple DNA damage response (DDR) pathways. Replicative stress and cellular exposure to genotoxic agents can lead to double- strand breaks (DSBs) which are the most lethal DNA lesions. Major DSB repair ...

Research Terms

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Megan T Baldridge

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$739,788

FY 2026

Project Title

Structural and functional definition of human astrovirus-receptor interactions

Grant Number:

5R01AI181955-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/19/2024

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Human astroviruses (HAstVs) are a global cause of pediatric gastroenteritis, and can cause disseminated infection in immunocompromised hosts. Seroprevalence studies indicate almost universal HAstV infection during childhood. Despite their clinical importance, HAstVs are hig...

Research Terms

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Joshua Frederick Robinson

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$715,736

FY 2026

Project Title

Delineating mechanisms underlying azole-induced developmental toxicity using single cell transcriptomic approaches, genome editing tools, and alternative models

Grant Number:

5R01ES033617-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/4/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary Azoles are antifungal agents widely-used in clinical applications and agriculture. Despite evident exposures in humans, the developmental health risks associated with azole exposures during pregnancy remains undefined. In vertebrate models, azoles cause developmental toxicity, including a sp...

Research Terms

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Christine Mayr

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$708,000

FY 2026

Project Title

Regulation of protein multi-functionality by 3 UTRs

Grant Number:

5R35GM144046-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/14/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Regulation of protein multi-functionality by 3′UTRs SUMMARY Many protein functions are mediated by protein complexes whose formation is often regulated by abundance as higher levels increase the chance to encounter an interaction partner. mRNAs contain a coding region that is translated into protein...

Research Terms

<3' Untranslated Regions><3'UTR><Binding Proteins><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Death><Cells><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Cytoplasmic Granules><Cytosol><Development><Elements><Engineering><Environment><Genes><Goals><Isoforms><Length><Ligand Binding Protein><Ligand Binding Protein Gene><Mediating><Membrane><Messenger RNA><Methods><Organelles><Phase><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Protein Binding><Protein Biosynthesis><Protein Isoforms><Protein Modification><Proteins><Regulation><Research><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Role><Therapeutic><Transcript><Translating><Translations><UTRs><Untranslated Regions><bound protein><developmental><granule><insoluble aggregate><mRNA><membrane structure><migration><necrocytosis><protein aggregate><protein aggregation><protein complex><protein function><protein protein interaction><protein synthesis><recruit><scaffold><scaffolding><social role><translation>

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Alexander Y Rudensky

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$698,720

FY 2026

Project Title

Self-Peptides Bound to MHC Class II in T Cell Selection

Grant Number:

5R01AI034206-32

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/1992

End Date:

10/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract Regulatory T (Treg) cells, serving as life-long guardians of the immune system, are distinguished by constitutive expression of transcription factor (TF) Foxp3, playing a critical role in their differentiation, function and fitness. Our previous studies showed that Foxp3 expression is stabl...

Research Terms

<21+ years old><Ablation><Abscission><Adult><Adult Human><Autoimmune><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Auxins><Basal Transcription Factor><Basal transcription factor genes><Binding><C57BL/6 Mouse><CRE Recombinase><CRISPR><CRISPR approach><CRISPR based approach><CRISPR interference><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR-dCas9-mediated repression><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Cancers><Cas nuclease technology><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell Therapy><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chromatin><Class II Genes><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats interference><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><Degenerative Disorder><Dependence><Development><Disease><Disorder><Ensure><Enterobacteria phage P1 Cre recombinase><Excision><Extirpation><FOXP3><FOXP3 gene><Forkhead Box P3><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic Transcription><Genetic propensity><Genetic study><HLA Class II Genes><Health><Immune system><In Vitro><Infection><Inflammation><Inflammatory><Inherited Predisposition><Inherited Susceptibility><Investigation><JM2><Life><Light><MHC Class II><MHC Class II Genes><Malignant Neoplasms><Malignant Tumor><Modeling><Molecular><Molecular Interaction><Organ><Pathogenesis><Peptides><Peripheral><Photoradiation><Physiologic><Physiological><Play><Process><Proteins><Publishing><RNA Expression><Recombinant DNA Technology><Regulatory T-Lymphocyte><Removal><Role><SCURFIN><Subcellular Process><Surgical Removal><Syndrome><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell differentiation><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cells><T-Lymphocyte><T-cell therapeutics><T-cell transfer therapy><Testing><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Treg><X Chromosome><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><adulthood><autoimmune condition><autoimmune disorder><autoimmunity disease><bacteriophage P1 recombinase Cre><cell based intervention><cell mediated intervention><cell mediated therapies><cell resilience><cell resiliency><cell-based therapeutic><cell-based therapy><cellular resilience><cellular resiliency><cellular therapeutic><cellular therapy><clinical significance><clinically significant><constitutive expression><constitutive gene expression><degenerative condition><degenerative disease><developmental><epigenome><fitness><gain of function><gene regulatory network><genetic vulnerability><genetically engineered><genetically predisposed><genome scale><genome-wide><genomewide><global gene expression><global transcription profile><in vivo><loss of function><malignancy><neoplasm/cancer><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><precursor cell><programs><regulatory T-cells><repressing CRISPR-dCas9 system><resection><resilience><resilient><social role><therapeutic T-cell platform><therapeutic target><thymus derived lymphocyte><transcription factor><transcriptome>

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L. David Sibley

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$676,502

FY 2026

Project Title

Genetic Basis of Host Infectivity by Cryptosporidium

Grant Number:

5R01AI175150-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/9/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Cryptosporidium is a wide-spread enteric pathogen that causes severe diarrheal disease in immunocompromised patients and infants, especially in the developing world. There are more than 20 described species of Cryptosporidium some of which show narrow host ranges while other...

Research Terms

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CHRISTOPHER D VULPE

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$667,789

FY 2026

Project Title

CRISPR screens of population relevant genes governing toxicant resilience

Grant Number:

5R01ES033625-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2022

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

People vary considerably in their response to and in the effects of exposure to chemical toxicants and biological toxins. As a result, the risk of adverse outcomes associated with exposure for different individuals and populations can be widely divergent. Gene by environment (G x E) interactions lik...

Research Terms

<3-D><3-Dimensional><3D><Adverse effects><Affect><Biological><CRISPR><CRISPR editing screen><CRISPR library><CRISPR screen><CRISPR-based library><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 library><CRISPR/Cas9 screen><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Growth in Number><Cell Line><Cell Multiplication><Cell Proliferation><Cell model><CellLine><Cells><Cellular Proliferation><Cellular model><Chemicals><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats library><Complex><Coupled><DNA mutation><Data Bases><Databases><Dose><Environment><Environmental Exposure><Evaluation><Exposure to><Frequencies><Gene Expression><Gene Transcription><Gene variant><Gene x Environment Interaction><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic Transcription><Genetic Variation><Genetic defect><Genetic mutation><Genetic propensity><GxE interaction><Health><Human><Human Genetics><Individual><Inherited Predisposition><Inherited Susceptibility><Libraries><Measures><Metabolic><Modern Man><Mutation><Organoids><Outcome><Pathway interactions><Persons><Phenotype><Physiologic><Physiological><Population><Predisposition><Preventive><Public Health><RNA Expression><Reporter><Research Resources><Resources><Risk><Risk Assessment><Role><Strains Cell Lines><Stress><Susceptibility><Therapeutic><Toxicant exposure><Toxicogenomics><Toxicology><Toxin><Transcription><Validation><Variant><Variation><adverse consequence><adverse outcome><allelic variant><biologic><biological adaptation to stress><candidate identification><cellular differentiation><clustered regularly interspaced short palindromic repeats screen><comparative><cultured cell line><data base><drug candidate><environment effect on gene><environmental stresses><environmental stressor><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><gene environment interaction><genetic association><genetic variant><genetic vulnerability><genetically predisposed><genome mutation><genomic variant><improved><loss of function><loss of function mutation><pathway><reactioncrisis><resilience><resilient><response><risk mitigation><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stress response><stressreaction><stressor><success><three dimensional><tool><toxic exposure><toxicant><validations><vector>

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David Cristopher Bragg

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$662,257

FY 2026

Project Title

Assembling the Genetic Architecture of X-linked Dystonia Parkinsonism

Grant Number:

5R01NS102423-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2017

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT X-linked dystonia-parkinsonism (XDP) is a fully penetrant and lethal neurodegenerative disorder in which symptoms of dystonia overlap with degenerative parkinsonism, reflective of the gradual loss of striatal neurons as the disease progresses. XDP represents a unique Mendelian disorder that...

Research Terms

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Clotilde Lagier-Tourenne

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$662,257

FY 2026

Project Title

Assembling the Genetic Architecture of X-linked Dystonia Parkinsonism

Grant Number:

5R01NS102423-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2017

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT X-linked dystonia-parkinsonism (XDP) is a fully penetrant and lethal neurodegenerative disorder in which symptoms of dystonia overlap with degenerative parkinsonism, reflective of the gradual loss of striatal neurons as the disease progresses. XDP represents a unique Mendelian disorder that...

Research Terms

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MICHAEL E TALKOWSKI

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$662,257

FY 2026

Project Title

Assembling the Genetic Architecture of X-linked Dystonia Parkinsonism

Grant Number:

5R01NS102423-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2017

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT X-linked dystonia-parkinsonism (XDP) is a fully penetrant and lethal neurodegenerative disorder in which symptoms of dystonia overlap with degenerative parkinsonism, reflective of the gradual loss of striatal neurons as the disease progresses. XDP represents a unique Mendelian disorder that...

Research Terms

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Thales Papagiannakopoulos

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$655,478

FY 2026

Project Title

Investigating the therapeutic potential of a novel glutamine antagonist in KEAP1 mutant lung cancer

Grant Number:

5R01CA262562-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/19/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Treating KRAS mutant lung adenocarcinoma (LUAD) remains a major challenge for clinical oncology. Approximately 20% of KRAS mutant LUAD tumors carry loss-of-function mutations in KEAP1, a negative regulator of NRF2, which is the master transcriptional regulator of the endogen...

Research Terms

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Robert F. Schwabe

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$655,429

FY 2026

Project Title

Understanding and Targeting Transcriptional Master Regulators in Hepatocellular Carcinoma

Grant Number:

5R01CA289606-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Hepatocellular carcinoma (HCC) causes nearly 800,000 deaths worldwide and represents one of the fastest- rising tumors in the US. Despite recent FDA approval of combination therapies for HCC, the majority of patients die within two years. A major challenge in this context is the high genetic diversi...

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Kirk J Wangensteen

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$655,429

FY 2026

Project Title

Understanding and Targeting Transcriptional Master Regulators in Hepatocellular Carcinoma

Grant Number:

5R01CA289606-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Hepatocellular carcinoma (HCC) causes nearly 800,000 deaths worldwide and represents one of the fastest- rising tumors in the US. Despite recent FDA approval of combination therapies for HCC, the majority of patients die within two years. A major challenge in this context is the high genetic diversi...

Research Terms

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Michael Berney

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$636,812

FY 2026

Project Title

Identification of new inhibitors of essential functions in M. tuberculosis by high-throughput metabolic profiling

Grant Number:

5R01AI173328-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/18/2022

End Date:

10/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract While the emergence of multi-drug resistant tuberculosis raises an urgent need for antimicrobials with new Modes of Action, their discovery remains a major challenge. Many of the techniques to unravel drug Modes of Action rely on low-throughput, time-consuming and target-spe...

Research Terms

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Mauricio Henriques Pontes

PENNSYLVANIA STATE UNIV HERSHEY MED CTR, HERSHEY, PA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$631,996

FY 2026

Project Title

Genetics and physiology of the tsetse fly bacterial endosymbiont Sodalis glossinidius

Grant Number:

5R01AI175509-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/8/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Tsetse flies (Glossina spp.; Diptera: Glossinidae) are the vectors of Trypanosoma spp., parasitic protozoa and causative agents of human sleeping sickness and Animal African trypanosomiasis. Natural populations of tsetse flies can be infected with strains of the endosymbiotic bacteri...

Research Terms

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MICHAEL T MCMANUS

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$629,170

FY 2026

Project Title

Orthogonal CRISPR GEMMs

Grant Number:

5R01CA279801-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The heart of this proposal is to overturn the existing one-gene-at-a-time paradigm for studying human genes in organismal model studies, and to push the envelope for studying genetic interactions in vivo. We have developed a technology to study gene interactions in mouse models using...

Research Terms

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Stephanie Cherqui

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$581,440

FY 2026

Project Title

Microgial contribution and therapeutic potential in Friedreich's ataxia

Grant Number:

5R01NS135162-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Friedreich’s ataxia (FRDA) is a multi-systemic autosomal recessive disorder that is predominantly caused by a homozygous GAA repeat expansion mutation within the first intron of the frataxin (FXN) gene leading to a decrease of protein expression. Frataxin is a mitochondrial protein i...

Research Terms

<15 year old><15 years of age><3-D><3-Dimensional><3D><Address><Affect><Allogenic><Ataxia><Ataxy><Autologous><Autoregulation><Binding><Biologic Models><Biological Models><Blood Cells><Blood Precursor Cell><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Brain><Brain Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiac><Cardiomyopathies><Cas nuclease technology><Cell Body><Cell Therapy><Cells><Cellular Stress><Cellular Stress Response><Cerebellum><Cerebrum><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Complex><Coordination Impairment><DNA mutation><Data><Degenerative Neurologic Disorders><Disease><Disorder><Disturbance in cognition><Dyssynergia><Encephalon><Exhibits><Fe metabolism><Fibroblasts><Freidreich's Ataxia><Friedreich Ataxia><Friedreich Disease><Friedreich Spinocerebellar Ataxia><Friedreich's Familial Ataxia><Friedreich's Hereditary Ataxia><Friedreich's Hereditary Spinal Ataxia><Friedreich's tabes><Genes><Genetic Change><Genetic Materials><Genetic defect><Genetic mutation><HSC transplantation><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Hereditary Spinal Sclerosis><Heterograft><Heterologous Transplantation><Homeostasis><Hortega cell><Human><Immune><Immunes><Impaired cognition><In Vitro><Inflammation><Inflammatory><Infusion><Infusion procedures><Intervening Sequences><Introns><Investigational Drugs><Investigational New Drugs><Macrophage><Mediating><Methods><Mice><Mice Mammals><Microglia><Mitochondria><Mitochondrial Proteins><Model System><Modern Man><Molecular Interaction><Murine><Mus><Muscle><Muscle Tissue><Muscle Weakness><Muscular Weakness><Mutation><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><Mφ><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological><Neurological Disorders><Neuron Degeneration><Neurons><Organoids><Pathogenesis><Pathologic><Pathology><Patients><Peripheral Blood Cell><Phenotype><Physiological Homeostasis><Progenitor Cell Transplantation><Proteins><Research Resources><Resources><Risk><Role><Route><Sensory><Stem Cell Transplantation><Stem cell transplant><Symptoms><System><Testing><Therapeutic><Time><Tissues><Translating><Transplantation><Trinucleotide Repeat Expansion><Wheel Chairs><Wheelchairs><Work><Xenograft><Xenograft Model><Xenograft procedure><Xenotransplantation><age 15><age 15 years><autosome><blood cell progenitor><blood progenitor><blood stem cell><blood stem cell transplantation><blood-forming stem cell><brain cell><cell based intervention><cell mediated intervention><cell mediated therapies><cell stress><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><cerebral><clinical applicability><clinical application><clinical translation><clinically translatable><cognitive dysfunction><cognitive loss><cohort><curative intervention><curative therapeutic><curative therapy><curative treatments><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><disease model><disorder model><exosome><expectation><family ataxia><fifteen year old><fifteen years of age><frataxin><gene corrected><gene correction><genome mutation><genomic correction><gitter cell><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><human derived model><human derived platform><human derived system><human like model><human like platform><human like system><human model><human specific alternative><human specific model><human specific platform><human specific system><human-based alternative><human-based biological models><human-based model><human-based nonanimal models><human-based platform><human-based research><human-based system><human-based tools><human-centered model><human-centered platform><human-centered research><human-centered system><human-focused research><human-relevant alternative><human-relevant model><human-relevant platform><human-relevant system><humanized mice><humanized mouse><iPS><iPSC><iPSCs><in vitro Model><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infusions><insight><iron metabolism><mesoglia><microglial cell><microgliocyte><mitochondrial><mitochondrial dysfunction><model of human><molecular phenotype><mouse model><murine model><muscular><myocardium disease><myocardium disorder><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neurological disease><neuronal><neuronal degeneration><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><perivascular glial cell><prevent><preventing><progenitor transplantation><protein expression><response><social role><stem and progenitor cell transplantations><success><three dimensional><transcriptomics><translation strategy><translational approach><translational strategy><transplant><xeno-transplant><xeno-transplantation><xenograft transplant model><xenotransplant model>

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Nicole Gabriele Coufal

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$581,440

FY 2026

Project Title

Microgial contribution and therapeutic potential in Friedreich's ataxia

Grant Number:

5R01NS135162-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Friedreich’s ataxia (FRDA) is a multi-systemic autosomal recessive disorder that is predominantly caused by a homozygous GAA repeat expansion mutation within the first intron of the frataxin (FXN) gene leading to a decrease of protein expression. Frataxin is a mitochondrial protein i...

Research Terms

<15 year old><15 years of age><3-D><3-Dimensional><3D><Address><Affect><Allogenic><Ataxia><Ataxy><Autologous><Autoregulation><Binding><Biologic Models><Biological Models><Blood Cells><Blood Precursor Cell><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Brain><Brain Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiac><Cardiomyopathies><Cas nuclease technology><Cell Body><Cell Therapy><Cells><Cellular Stress><Cellular Stress Response><Cerebellum><Cerebrum><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Complex><Coordination Impairment><DNA mutation><Data><Degenerative Neurologic Disorders><Disease><Disorder><Disturbance in cognition><Dyssynergia><Encephalon><Exhibits><Fe metabolism><Fibroblasts><Freidreich's Ataxia><Friedreich Ataxia><Friedreich Disease><Friedreich Spinocerebellar Ataxia><Friedreich's Familial Ataxia><Friedreich's Hereditary Ataxia><Friedreich's Hereditary Spinal Ataxia><Friedreich's tabes><Genes><Genetic Change><Genetic Materials><Genetic defect><Genetic mutation><HSC transplantation><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Hereditary Spinal Sclerosis><Heterograft><Heterologous Transplantation><Homeostasis><Hortega cell><Human><Immune><Immunes><Impaired cognition><In Vitro><Inflammation><Inflammatory><Infusion><Infusion procedures><Intervening Sequences><Introns><Investigational Drugs><Investigational New Drugs><Macrophage><Mediating><Methods><Mice><Mice Mammals><Microglia><Mitochondria><Mitochondrial Proteins><Model System><Modern Man><Molecular Interaction><Murine><Mus><Muscle><Muscle Tissue><Muscle Weakness><Muscular Weakness><Mutation><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><Mφ><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological><Neurological Disorders><Neuron Degeneration><Neurons><Organoids><Pathogenesis><Pathologic><Pathology><Patients><Peripheral Blood Cell><Phenotype><Physiological Homeostasis><Progenitor Cell Transplantation><Proteins><Research Resources><Resources><Risk><Role><Route><Sensory><Stem Cell Transplantation><Stem cell transplant><Symptoms><System><Testing><Therapeutic><Time><Tissues><Translating><Transplantation><Trinucleotide Repeat Expansion><Wheel Chairs><Wheelchairs><Work><Xenograft><Xenograft Model><Xenograft procedure><Xenotransplantation><age 15><age 15 years><autosome><blood cell progenitor><blood progenitor><blood stem cell><blood stem cell transplantation><blood-forming stem cell><brain cell><cell based intervention><cell mediated intervention><cell mediated therapies><cell stress><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><cerebral><clinical applicability><clinical application><clinical translation><clinically translatable><cognitive dysfunction><cognitive loss><cohort><curative intervention><curative therapeutic><curative therapy><curative treatments><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><disease model><disorder model><exosome><expectation><family ataxia><fifteen year old><fifteen years of age><frataxin><gene corrected><gene correction><genome mutation><genomic correction><gitter cell><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><human derived model><human derived platform><human derived system><human like model><human like platform><human like system><human model><human specific alternative><human specific model><human specific platform><human specific system><human-based alternative><human-based biological models><human-based model><human-based nonanimal models><human-based platform><human-based research><human-based system><human-based tools><human-centered model><human-centered platform><human-centered research><human-centered system><human-focused research><human-relevant alternative><human-relevant model><human-relevant platform><human-relevant system><humanized mice><humanized mouse><iPS><iPSC><iPSCs><in vitro Model><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infusions><insight><iron metabolism><mesoglia><microglial cell><microgliocyte><mitochondrial><mitochondrial dysfunction><model of human><molecular phenotype><mouse model><murine model><muscular><myocardium disease><myocardium disorder><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neurological disease><neuronal><neuronal degeneration><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><perivascular glial cell><prevent><preventing><progenitor transplantation><protein expression><response><social role><stem and progenitor cell transplantations><success><three dimensional><transcriptomics><translation strategy><translational approach><translational strategy><transplant><xeno-transplant><xeno-transplantation><xenograft transplant model><xenotransplant model>

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Michael A Erb

SCRIPPS RESEARCH INSTITUTE, THE, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$580,318

FY 2026

Project Title

Cancer-specific dependencies within the NuRD chromatin remodeler complex: new targets and chemical tools

Grant Number:

5R01CA280720-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Histone deacetylases (HAT) are zinc-dependent enzymes that catalyze the removal of acetyl groups from the epsilon amine of lysine side chains. These proteins have been widely pursued as anti-cancer drug targets, but therapeutic development has been largely unsuccessful given...

Research Terms

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Gregory M Barton

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$541,171

FY 2026

Project Title

Regulation of TLR trafficking for proper self versus non-self discrimination

Grant Number:

5R01AI072429-18

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2008

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Inappropriate recognition of self nucleic acids (NA) by members of the Toll-like receptor (TLR) family can result in autoimmune diseases such as lupus and psoriasis. TLR7 (and TLR8 in humans) and TLR9 can be activated by self RNA and DNA, respectively, so defining the mechanisms tha...

Research Terms

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Iannis Aifantis

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$540,134

FY 2026

Project Title

mRNA stability and its impact on hematopoiesis and acute leukemia

Grant Number:

5R01CA266212-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract This application focuses on acute myeloid leukemia (AML), a blood cancer that is characterized by low survival rates and few available targeted therapies. The five-year overall survival rate for AML is below 30 percent in adults and around 65% in children. Interestingly, one type of interve...

Research Terms

<0-11 years old><21+ years old><3' Untranslated Regions><3'UTR><AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Acute Promyelocytic Leukemia><Acute leukemia><Adult><Adult Human><Affect><Apoptosis><Apoptosis Pathway><Binding><Binding Proteins><Blood monocyte><CRISPR approach><CRISPR based approach><CRISPR editing screen><CRISPR method><CRISPR methodology><CRISPR screen><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based screen><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 screen><CRISPR/Cas9 technology><Cancers><Cas nuclease technology><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Physiology><Cell Process><Cell Surface Antigens><Cells><Cellular Expansion><Cellular Function><Cellular Growth><Cellular Physiology><Cellular Process><Child><Child Youth><Children (0-21)><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Data><Differentiation Therapy><Drugs><EGF-Response Factor 2><ERF2><Elements><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Family><Gene Expression><Genetic Diseases><Granulocytic Leukemia><Hematopoiesis><Hematopoietic><Hematopoietic Cell Tumor><Hematopoietic Cellular Control Mechanisms><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Human><Human Genetics><Immunological Surface Markers><In Vitro><Intervention><Laboratories><Length><Leukemic Cell><Leukemic progenitor and stem cell><Ligand Binding Protein><Ligand Binding Protein Gene><Maintenance><Malignant><Malignant - descriptor><Malignant Hematopoietic Neoplasm><Malignant Neoplasms><Malignant Tumor><Maps><Marrow monocyte><Medication><Messenger RNA><Mice><Mice Mammals><Modern Man><Modification><Molecular Interaction><Mouse Homolog of TIS11D><Murine><Mus><Myelocytic Leukemia><Myelogenous><Myelogenous Leukemia><Myeloid><Myeloid Leukemia><Myeloid Leukemia, Acute, M3><Non-Lymphoblastic Leukemia><Non-Lymphocytic Leukemia><Non-Polyadenylated RNA><Nonlymphoblastic Leukemia><Nonlymphocytic Leukemia><Patients><Pattern><Pharmaceutical Preparations><Poly(A) Tail><Post-Transcriptional Control><Post-Transcriptional Regulation><Progenitor Cells><Programmed Cell Death><Progranulocytic Leukemia><Protein Binding><Proteins><Putative RNA-Binding Region><RNA><RNA Binding Domain><RNA Gene Products><RNA Recognition Motif><RNA Splicing><RNA-Binding Proteins><RNP Domain><RNP Motif><RNP-1 Signature><Regulator Genes><Regulon><Ribonucleic Acid><Role><Shapes><Spliceosomes><Splicing><Stem Cell like><Subcellular Process><Surface Antigens><Survival Rate><TIS11D><Testing><Transcript><Transcriptional Regulatory Elements><Tumor Cell><Undifferentiated><Yin><ZFP36-Like 2><ZFP36L2><ZFP36L2 gene><Zinc Finger Domain><Zinc Finger Motifs><Zinc Finger Protein 36-Like 2><Zinc Fingers><acute granulocytic leukemia><acute granulocytic leukemia cell><acute myeloblastic leukemia cell><acute myelocytic leukemia cell><acute myelogenous leukemia cell><acute myeloid leukemia><acute myeloid leukemia cell><acute nonlymphocytic leukemia cell><adulthood><blood cancer><blood cell formation><bound protein><cancer of blood><cancer of the blood><cancer progression><cell growth><cellular differentiation><clustered regularly interspaced short palindromic repeats screen><drug/agent><epigenetically><epigenome profiling><epigenomic profiling><gain of function><genetic condition><genetic disorder><genetic trans acting element><genome scale><genome-wide><genomewide><hemopoietic><in vivo><kids><leukemia><leukemia stem/initiating cells><leukemic progenitor><leukemic stem cell><leukemic transformation><mRNA><mRNA Degradation><mRNA Stability><mRNA Transcript Degradation><mRNA Translation><malignancy><member><monocyte><myeloid granulocytic leukemia><myelosis><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><novel><overexpress><overexpression><paralog><paralogous gene><post-transcriptional gene regulation><posttranscriptional><progenitor><progenitor capacity><progenitor cell differentiation><progenitor cell like><progenitor differentiation><progenitor-like><promyelocytic leukemia><regulatory gene><screening><screenings><self-renew><self-renewal><social role><stem><stem and progenitor differentiation><stem cell characteristics><stem cell differentiation><stem cells><stem-like><stemness><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><trans acting element><tumor initiation><tumor progression><youngster>

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Kimberly Lynn Cooper

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$521,400

FY 2026

Project Title

Development of approaches to apply CRISPR/Cas9-mediated gene conversion to model complex genetic traits in mice

Grant Number:

5R01GM148640-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Decades of research using laboratory mice and rats have revealed mechanisms of human development and disease. It is highly likely that rodents have provided critical supporting data for clinical trials of every pharmaceutical or therapeutic approach currently used to improve human h...

Research Terms

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Chris Tonkin

WALTER AND ELIZA HALL INST MEDICAL RES, AUSTRALIA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$520,009

FY 2026

Project Title

Regulation of latent stage differentiation through central carbon metabolism and ubiquitination

Grant Number:

5R01AI172823-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/5/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project summary Toxoplasma latently infects approximately 30% of the human population and is refractory to acute stage therapies. Latent Toxoplasma can act as a reservoir for acute stage reactivation in immunocompromised individuals and can cause progressive blindness in otherwise healthy individual...

Research Terms

<APF-1><ATP-Dependent Proteolysis Factor 1><Acute><Amino Acids><Biochemical><Biology><Blindness><Body Tissues><Brain><Brain Nervous System><CNS Nervous System><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas9 screen><Carbon><Cell Communication and Signaling><Cell Signaling><Central Nervous System><Clinical><Complex><Country><Cues><Development><Differentiation in cell culture><Disease><Disorder><Drug resistance><Drugs><E3 Ligase><E3 Ubiquitin Ligase><Encephalon><Environment><Enzyme Gene><Enzymes><Exposure to><Gene Transcription><Genes><Genetic><Genetic Screening><Genetic Transcription><Gln><Glutamine><HMG-20><High Mobility Protein 20><Human><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><In vitro cell differentiation><Individual><Intermediary Metabolism><Intracellular Communication and Signaling><L-Glutamine><Life><Link><Medication><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Methodology><Modern Man><Muscle><Muscle Tissue><Neuraxis><Nutritional><Parasites><Pathogenesis><Patients><Pharmaceutical Preparations><Play><Population><Prevalence><Proteomics><Publishing><Q Levoglutamide><Q. Levoglutamide><RNA Expression><Refractory><Regulation><Role><Signal Transduction><Signal Transduction Systems><Signaling><Source><Structure><Techniques><Tissues><Toxoplasma><Transcription><Translations><Ubiquitilation><Ubiquitin><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><Work><aminoacid><biological signal transduction><brain tissue><clustered regularly interspaced short palindromic repeats screen><developmental><differentiation in culture><differentiation in vitro><drug resistant><drug/agent><entire genome><full genome><genome scale><genome-wide><genomewide><immunosuppressed patient><in vitro cellular differentiation><in vivo><insight><latent infection><metabolism measurement><metabolomics><metabonomics><model organism><muscular><nutritious><programs><resistance to Drug><resistance to therapy><resistant to Drug><resistant to therapy><social role><therapeutic resistance><therapy resistant><translation><treatment resistance><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase><vision loss><visual loss><whole genome>

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Abhinav Diwan

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$489,248

FY 2026

Project Title

Mitophagy and Cardiac Myocyte Protein Aggregation

Grant Number:

5R01HL107594-14

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2011

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Cardiac myocyte protein quality control is critical for maintenance of the contractile apparatus and cardiac function. Mutations in chaperone proteins that affect protein quality control induce proteotoxicity, sarcomere dysfunction and cardiac myocyte cell death. One such point mutation in the CRYAB...

Research Terms

<21+ years old><Ablation><Abscission><Adaptor Protein><Adaptor Protein Gene><Adaptor Signaling Protein><Adaptor Signaling Protein Gene><Adult><Adult Human><Adverse effects><Affect><Aminoacetic Acid><Arginine><Attenuated><Autophagocytosis><Biologic Models><Biological Models><Body Tissues><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac Transplantation><Cardiocyte><Cardiomyopathies><Cas nuclease technology><Cell Body><Cell Death><Cell Line><CellLine><Cells><Cessation of life><Chaperone><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Coupled><Crystallins><Cytosol><DNA mutation><Data><Death><Development><Dysfunction><Ensure><Excision><Extirpation><Functional disorder><Funding><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Glycine><Grant><Heart Grafting><Heart Muscle Cells><Heart Transplantation><Heart failure><Heart myocyte><Heat shock proteins><Human><Impairment><Innate Immunity><Knock-in><L-Arginine><Lysosomes><Maintenance><Mammalian Cell><Mediating><Mice><Mice Mammals><Mitochondria><Mitochondrial Proteins><Model System><Modeling><Modern Man><Molecular Chaperones><Murine><Mus><Muscle Proteins><Muscle Weakness><Muscular Weakness><Mutation><Myocardial Diseases><Myocardial Disorder><Myocardial depression><Myocardial dysfunction><Myocardiopathies><Myocardium><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Pathology><Pathway interactions><Physiopathology><Point Mutation><Position><Positioning Attribute><Premature Mortality><Process><Proteins><Quality Control><Reagent><Removal><Role><Sarcomeres><Strains Cell Lines><Structure><Surgical Removal><TRAF2><TRAF2 gene><TRAP3><Testing><Therapeutic><Tissues><Transgenic Mice><Treatment Efficacy><Troponin T><Visualization><Work><Yeast Model System><Yeasts><adapter protein><adulthood><attenuate><attenuates><autophagy><autosome><cardiac dysfunction><cardiac failure><cardiac function><cardiac graft><cardiac muscle><cardiac myocytes differentiated from induced pluripotent stem cell><cardiomyocyte><cultured cell line><developmental><experiment><experimental research><experimental study><experiments><function of the heart><genome mutation><heart dysfunction><heart function><heart muscle><heart transplant><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPS cell derived cardiomyocytes><iPSC><iPSC derived cardiomyocytes><iPSCs><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell derived cardiac myocytes><induced pluripotent stem cell derived cardiomyocytes><inducible pluripotent cell><inducible pluripotent stem cell><inducible pluripotent stem cell derived cardiac myocytes><inducible pluripotent stem cells derived cardiomyocytes><insoluble aggregate><intervention efficacy><knockin><lens protein><life span><lifespan><mitochondrial><mouse model><murine model><mutant><myocardium disease><myocardium disorder><necrocytosis><neonatal mice><novel><overexpress><overexpression><pathophysiology><pathway><pharmacologic><premature><prematurity><preservation><prevent><preventing><promoter><promotor><protein aggregate><protein aggregation><protein expression><proteotoxic><proteotoxicity><resection><social role><stress protein><superresolution imaging><therapeutic efficacy><therapy efficacy><tropomyosin binding protein troponin T><uptake><yeast model>

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Michael Buszczak

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$488,952

FY 2026

Project Title

Genetic Dissection of Germ Cell Differentiation and Function

Grant Number:

5R35GM144043-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Summary The study of germ cells has shaped our understanding of many basic fundamental processes across different species. Germ cells share a number of features that have long fascinated biologists. These cells undergo meiosis to form haploid gametes, they are exceptionally good at repairing DNA dam...

Research Terms

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MIRIAM H MEISLER

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$465,915

FY 2026

Project Title

Functional Genetics of the Neuronal Sodium Channel Gene SCN8A

Grant Number:

5R01NS034509-29

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/1996

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT During the previous funding period, we generated a conditional mouse model of the recurrent sodium channel mutation SCN8A-p.R1872W that is responsible for the rare, devastating disorder Developmental Epileptic Encephalopathy (DEE). We demonstrated that expression of the mutant channel in ex...

Research Terms

<0-11 years old><AAV vector><AAV-based vector><ASO therapeutics><ASO therapy><ASO treatment><Action Potentials><Affect><Alleles><Allelomorphs><Ammon Horn><Antisense Agent><Antisense Oligonucleotide Therapy><Antisense Oligonucleotides><Ataxia><Ataxy><Brain><Brain Nervous System><Brain region><CRISPR><CRISPR approach><CRISPR based approach><CRISPR based therapeutics><CRISPR based treatment><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR therapeutics><CRISPR tools><CRISPR treatment><CRISPR-CAS-9><CRISPR-Cas based therapeutics><CRISPR-based disease therapeutics><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based therapy><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas therapeutics><CRISPR/Cas9><CRISPR/Cas9 technology><CRISPR/Cas9 therapeutics><CRISPR/Cas9 therapy><CRISPR/Cas9 treatment><CRISPR/Cas9-based therapy><Cas nuclease technology><Cas9 based therapeutics><Cerebellum><Child><Child Youth><Children (0-21)><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats based therapeutics><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Clustered Regularly Interspaced Short Palindromic Repeats therapeutics><Cognition><Cognitive><Coordination Impairment><Cornu Ammonis><DNA Therapy><DNA mutation><Decreased Muscle Tone><Dependence><Development><Disease><Disorder><Dorsal><Down-Regulation><Drug Therapy><Drugs><Dysfunction><Dyssynergia><EEG><Effectiveness><Electroencephalogram><Electroencephalography><Encephalon><Engineering><Entorhinal Area><Epilepsy><Epileptic Seizures><Epileptics><Fore-Brain><Forebrain><Functional disorder><Funding><Future><Gene Alteration><Gene Mutation><Gene Transfer Clinical><Genes><Genetic><Genetic Change><Genetic Intervention><Genetic defect><Genetic mutation><Goals><Heterozygote><Hippocampus><Human><Hypomyotonia><Hypotonia><Impairment><In Vitro><Increase lifespan><Individual><Injections><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Investigators><Knock-out><Knockout><Length><Life><LoxP-flanked allele><Medication><Mice><Mice Mammals><Missense Mutation><Modern Man><Motor><Movement><Murine><Mus><Muscle Hypotony><Muscle Tone Poor><Muscle hypotonia><Muscular Hypotonia><Mutation><Myoclonic Jerk><Myoclonus><NAV1.6><NaCh6><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Nucleotides><Pathogenicity><Pathology><Patients><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Physiopathology><Property><Prosencephalon><Purkinje Cells><Purkinje's Corpuscles><Recurrence><Recurrent><Reporting><Research Personnel><Researchers><Role><SCN8A><SCN8A gene><Seizure Disorder><Seizures><Sodium Channel><Sodium Ion Channels><Source><Sudden Death><Syndrome><Thalamic structure><Thalamus><Therapeutic><Therapeutic Effect><Therapeutic Intervention><Transcript><Transgenic Organisms><Treatment Efficacy><Variant><Variation><Viral><Viral Vector><Work><adeno-associated viral vector><adeno-associated virus vector><anti-sense oligonucleotide drug><anti-sense oligonucleotide therapy><anti-sense oligonucleotide treatment><anti-sense therapy><antisense drug><antisense oligo><antisense oligonucleotide therapeutic><antisense therapeutics><antisense therapy><assess effectiveness><auditory stimulus><body movement><boost longevity><cerebellar Purkinje cell><co-morbid><co-morbidity><comorbidity><determine effectiveness><developmental><developmental disease><developmental disorder><developmental epileptic encephalopathy><disease causing variant><disease-causing allele><disease-causing mutation><drug intervention><drug treatment><drug/agent><early onset><effective therapy><effective treatment><effectiveness assessment><effectiveness evaluation><elongating the lifespan><enhance longevity><entorhinal cortex><epilepsia><epileptic encephalopathies><epileptogenic><evaluate effectiveness><examine effectiveness><excitatory neuron><exome sequencing><exome-seq><experience><experiment><experimental research><experimental study><experiments><extend life span><extend lifespan><extend longevity><floxed><floxed allele><foster longevity><gain of function mutation><gene defect><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genome mutation><genomic therapy><heterozygosity><hippocampal><improve lifespan><improve longevity><improved><insight><intellectual and developmental disability><intervention efficacy><intervention therapy><kids><lifespan extension><limited intellectual functioning><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><motor impairment><mouse model><movement impairment><movement limitation><murine model><mutant><mutant allele><neurological disease><neuronal><neuronal excitability><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><pathogenic allele><pathogenic variant><pathophysiology><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pre-clinical><preclinical><prevent><preventing><prolong lifespan><prolong longevity><promote lifespan><promote longevity><response><shRNA><short hairpin RNA><side effect><social role><sodium channel, voltage gated, type VIII, alpha subunit><standard care><standard treatment><support longevity><thalamic><therapeutic effectiveness><therapeutic efficacy><therapeutically effective><therapy efficacy><transgenic><translational opportunities><translational potential><voltage><youngster>

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Luciano A Marraffini

ROCKEFELLER UNIVERSITY, NEW YORK, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$435,464

FY 2026

Project Title

Spacer acquisition during the type III-A CRISPR-Cas immune response

Grant Number:

5R01GM149834-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary CRISPR-Cas systems provide bacteria and archaea with adaptive immunity against their viruses (phages). The hallmark of the CRISPR-Cas immune response is the acquisition of a “memory” of infection in the form of a short DNA sequence from the invading phage genome. This sequence, known...

Research Terms

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Valerie Cortez

UNIVERSITY OF CALIFORNIA SANTA CRUZ, SANTA CRUZ, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$422,677

FY 2026

Project Title

The multifaceted pathways of astrovirus entry and egress

Grant Number:

1R35GM162359-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/24/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Astroviruses are a major cause of pediatric diarrhea worldwide. Despite causing one of the most common early childhood infections, astroviruses are one of the least studied enteric RNA viruses. We previously discovered that the virus infects small intestinal goblet cells, specialized...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Address><Astrovirus><Biochemical><Biology><COVID-19 virus><COVID19 virus><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell model><Cells><Cellular model><Childhood><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><CoV-2><CoV2><Cryo-electron Microscopy><Cryoelectron Microscopy><Development><Diarrhea><Electron Cryomicroscopy><Endocytosis><Engineering><Ensure><Enteral><Enteric><Family><Foundations><Future><Goblet Cells><Grippe><Human><Infection><Influenza><Intestinal><Intestines><Knowledge><Light><Liquid substance><Mediating><Mice><Mice Mammals><Microscopy><Modeling><Modern Man><Mucous body substance><Mucus><Mucus-Secreting Cell><Murine><Mus><Pathway interactions><Phase><Photoradiation><Play><Population><Preventative strategy><Prevention strategy><Preventive strategy><RNA Viruses><Receptor Protein><Resolution><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Specialized Epithelial Cell><Surface><Techniques><Viral><Viral Diseases><Virus><Virus Diseases><Virus Replication><Work><Wuhan coronavirus><apical membrane><bowel><coronavirus disease 2019 virus><coronavirus disease-19 virus><cryo-EM><cryoEM><cryogenic electron microscopy><developmental><early childhood><enteric viral infection><enteric virus infection><fluid><hCoV19><in vitro Model><insight><interest><liquid><mucous><nCoV2><novel><pathway><pediatric><receptor><resolutions><respiratory><social role><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><treatment strategy><viral infection><viral multiplication><viral replication><virus host interaction><virus infection><virus multiplication><virus-induced disease>

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MING CHEN

DUKE UNIVERSITY, DURHAM, NC

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$416,540

FY 2026

Project Title

Engineering Large Chromosomal Deletions in Mice to Advance Precision Oncology

Grant Number:

5R01CA261949-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract Genomic deletions, including both focal and large arm-level chromosomal deletions, are frequent genetic events that promote cancer initiation and progression. Focal deletions have yielded significant insights into mechanisms underlying tumorigenesis by helping identify tumor...

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Peter Z Qin

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$412,500

FY 2026

Project Title

Elucidating the Role of DNA Shape in CRISPR Target Discrimination

Grant Number:

5R35GM145341-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary This proposal centers on uncovering intrinsic physical properties of DNA duplex (i.e., DNA shape) and elucidating their roles in CRSIPR Cas9 and Cas12a target discrimination. CRISPR (Clustered-Regularly- Interspaced-Short-Palindromic-Repeats) systems have been adapted into versatile...

Research Terms

<3-D><3-Dimensional><3D><Affect><Algorithms><Base Pairing><Basic Research><Basic Science><Biology><CRISPR><CRISPR/Cas system><Cell Body><Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Cognitive Discrimination><Complex><DNA><DNA Sequence><DNA-Binding Proteins><Deoxyribonucleic Acid><Development><Development and Research><Discrimination><Distal><Double-Stranded DNA><Engineering><Gene Targeting><Genes><Genome><Guide RNA><Learning><Methods><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Non-Polyadenylated RNA><Nucleic Acids><Peripheral><Proteins><R & D><R&D><RNA><RNA Gene Products><Ribonucleic Acid><Role><Shapes><Site><Specificity><Spin Labels><System><Technology><Therapeutic><Work><conformation><conformational><conformational state><conformationally><conformations><developmental><ds-DNA><dsDNA><gRNA><genome editing><genome scale><genome-wide><genomewide><genomic editing><improved><next generation><physical property><research and development><social role><therapeutic agent development><therapeutic development><three dimensional>

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Jingshu Wang

UNIVERSITY OF CHICAGO, CHICAGO, IL

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$410,000

FY 2026

Project Title

Causal Inference in Genetics: Integrative Methods for Mendelian Randomization and Single-Cell CRISPR Screening

Grant Number:

1R35GM162500-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

This research project aims to develop innovative computational methods to enhance causal inference in genetics and genomics, addressing key challenges in understanding how genetic variation drives disease mechanisms. Advances in sequencing technologies, biobanks, and multi-omics datasets have provid...

Research Terms

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Sabrina Absalon

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$396,250

FY 2026

Project Title

Defining Centriolar Plaque Architecture and Function Across Eukaryotic Diversity Using Expansion Microscopy and Proteomics

Grant Number:

1R35GM161216-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

This research proposal aims to decode the structural and molecular architecture of centriolar plaques (CPs), a non-centrosomal microtubule organizing center, in the context of atypical eukaryotic cell division. Using expansion microscopy (U-ExM), we will map CP composition and dynamics with high res...

Research Terms

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Alice Accorsi

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$393,008

FY 2026

Project Title

Regulation of cell fate specification to regenerate complex sensory organs

Grant Number:

1R35GM162505-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Some animals have very robust regenerative capacities while others, like humans, have more limited ones. The severity of the injury, as well as the type of the tissue damaged and the animal age, can all impact the regeneration outcomes. Sensory organs are of particular interest to r...

Research Terms

<21+ years old><Adult><Adult Human><Age><Amputation><Animals><Apple><Automobile Driving><Body Tissues><CNS Nervous System><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Fate Control><Cell Fate Regulation><Central Nervous System><Cephalic><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><Cranial><Data Set><Developmental Gene><Embryo Development><Embryogenesis><Embryonic Development><Environment><Eye><Eyeball><Fresh Water><Freshwater><Future><Gene Transcription><Genetic Transcription><Genetics-Mutagenesis><Genome><Goals><Human><Injury><Knowledge><Laboratories><Malus domestica><Messenger RNA><Methods><Modern Man><Molecular><Mutagenesis><Mutagenesis Molecular Biology><Natural regeneration><Neuraxis><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Organ><Organism><Outcome><Play><Process><RNA Expression><Regeneration><Regenerative Medicine><Regenerative capacity><Regulatory Regions><Research><Role><Sensory><Severities><Snails><System><Tissues><Transcription><adult animal><adulthood><ages><cell fate specification><cell type><driving><eye regeneration><gene function><gene regulatory network><genetic regulatory element><injuries><insight><interest><living system><mRNA><mature animal><new approaches><novel approaches><novel strategies><novel strategy><organ regeneration><overexpress><overexpression><programs><regenerate><regeneration ability><regeneration capacity><regenerative><response><social role><tool><transcriptomics>

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Tina Y Liu

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$392,500

FY 2026

Project Title

Exploring Diverse Mechanisms of Type III CRISPR-Cas signaling.

Grant Number:

5R35GM156941-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/3/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Exploring Diverse Mechanisms of Type III CRISPR-Cas signaling Microbes called bacteria and archaea are the most abundant organisms on Earth and play an essential role in our health and well-being. Like us, they use sophisticated mechanisms to defend themselves from viral infection. O...

Research Terms

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Jingshi Shen

UNIVERSITY OF COLORADO, Boulder, CO

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$391,250

FY 2026

Project Title

Discovering protein networks underlying regulated exocytosis

Grant Number:

5R35GM126960-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2018

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Regulated exocytosis – stimulus-dependent exocytic vesicle fusion – mediates a broad range of fundamental biological processes including nutrient homeostasis, cell-to-cell signaling, and elimination of transformed or virally infected cells. Imbalances in these exocytic pathways lead ...

Research Terms

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NEIL J. GANEM

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$386,685

FY 2026

Project Title

Regulation of cell growth and proliferation by the Hippo pathway

Grant Number:

5R01GM117150-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/23/2016

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Precise regulation of cell growth and proliferation is necessary to maintain tissue homeostasis and organ size, and this regulation is predominantly controlled by two highly conserved signaling pathways: the Hippo and mammalian target of rapamycin (mTOR) pathways. Deregulati...

Research Terms

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Mohammed Abdul Muneer

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$368,750

FY 2026

Project Title

Neutrophil extracellular traps and associated pathogenesis in TBI: a novel peptide therapeutic strategy

Grant Number:

7R01NS133233-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/6/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT Traumatic brain injury (TBI) causes the blood-brain barrier (BBB) dysfunction and transmigration of inflammatory immune cells into the brain, an important mechanism underlying neurovascular damage and neuroinflammation. Adhesion of leukocytes to endothelial cells is a critical step in the m...

Research Terms

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Thomas Gaj

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$365,804

FY 2026

Project Title

Development of a CRISPR-Cas13 Gene Therapy for SOD1-Linked ALS

Grant Number:

5R01NS123556-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Amyotrophic lateral sclerosis (ALS) is a rapidly progressive, paralytic disorder characterized by the selective loss of motor neurons in the spinal cord and brain. While most cases of ALS are sporadic, toxic gain-of-function mutations in superoxide dismutase 1 (SOD1) are responsible ...

Research Terms

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Sean Patrick Ryder

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$360,125

FY 2026

Project Title

Unmasking the role of maternal transcript UTRs in reproductive fecundity

Grant Number:

5R01HD111505-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary: My lab is interested in defining how the maternal load is established during oogenesis and decoded af- ter fertilization. We know the identity of the most important maternal transcripts and maternally supplied RNA- binding proteins. We know which factors are required for germline d...

Research Terms

<0-11 years old><21+ years old><3' Untranslated Regions><3'UTR><Address><Adult><Adult Human><Affect><Animals><Bacteria><Buffers><C elegans><C. elegans><C.elegans><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Caenorhabditis elegans><Cas nuclease technology><Cell Body><Cells><Child><Child Youth><Children (0-21)><Clinic><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cues><Cytoplasm><DNA><DNA mutation><Data><Deoxyribonucleic Acid><Development><Double-Stranded RNA><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Ensure><Environment><Environmental Factor><Environmental Risk Factor><Event><Exposure to><Failure><Fecundability><Fecundity><Female><Fertility><Fertilization><Fertilized Egg><Fertilized Ovum><Fishes><Food Chain><Gametes><Gametogenesis><Gender><Gene Action Regulation><Gene Activation><Gene Deletion><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Targeting><Gene Transcription><Generalized Growth><Generations><Genes><Genetic Change><Genetic Models><Genetic Screening><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genomics><Germ Cells><Germ Lines><Germ-Line Cells><Gestation><Growth><Health><Heat Stress><Hereditary><High temperature of physical object><Hives><Hornets><Individual><Inherited><Instruction><Invertebrata><Invertebrates><Investigation><Laboratories><Learning><Mammalia><Mammals><Maps><Masked mRNA><Maternal Messenger RNA><Maternal mRNA><Measures><Meiosis><Messenger RNA><Molecular><Molecular Genetics><Mutate><Mutation><Nematoda><Nematodes><Non-Polyadenylated RNA><Oocytes><Oogenesis><Ovocytes><Parents><Pathway interactions><Pattern><Pattern Formation><Phenotype><Physiologic><Physiological><Plants><Play><Position><Positioning Attribute><Post-Transcriptional Control><Post-Transcriptional Gene Silencing><Post-Transcriptional Regulation><Pregnancy><Process><Property><Proteins><RNA><RNA Expression><RNA Gene Products><RNA Interference><RNA Silencing><RNA interference screen><RNA, Messenger, Masked><RNA, Messenger, Stored><RNA-Binding Proteins><RNAi><RNAi screen><RNAi-based screen><Regulation><Reiterated Genes><Reporter><Reproduction><Reproductive Biology><Reproductive Cells><Reptiles><Reptilia><Ribonucleic Acid><Risk><Role><Sequence-Specific Posttranscriptional Gene Silencing><Sex Cell><Sex Ratio><Sexual Reproduction><Sterility><Stored mRNA><Stress><Survey Instrument><Surveys><Temperature><Testing><Time><Tissue Growth><Transcript><Transcription><Translating><Translations><Turtles><UTRs><Untranslated Regions><Urticaria><Visualization><Wing><adulthood><cell fate specification><climate change><climatic changes><defined contribution><developmental><dsRNA><environmental change><environmental risk><experiment><experimental research><experimental study><experiments><feeding><fertilizations><gene deletion mutation><gene redundancy><gene replacement><genome editing><genome mutation><genome scale><genome-wide><genomewide><genomic editing><global climate change><high temperature><initial cell><interdisciplinary approach><interest><kids><mRNA><male><meiotic><model organism><multidisciplinary approach><mutant><notch><notch protein><notch receptors><ontogeny><oocyte maturation><parent><pathway><post-transcriptional gene regulation><reproductive><reproductive success><roundworm><sex determination><sexual cell><social role><spatial and temporal><spatial temporal><spatiotemporal><sterile><success><tool><tortoise><translation><ventilation><youngster><zygote><♀><♂>

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MICHAEL T LONGAKER

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$355,466

FY 2026

Project Title

Reprogramming fibroblasts embryonic origins to overcome skin fibrosis and scarring.

Grant Number:

5R01DE032677-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

7. Project Summary/Abstract Adult human skin heals by developing fibrotic scar tissue, which can result in devastating disfigurement, growth restriction, and permanent functional loss. Despite a plethora of clinical options, no current treatment strategies successfully prevent or reverse this fibrot...

Research Terms

<21+ years old><Abdomen><Accounting><Adult><Adult Human><BET bromodomain inhibitor><BET inhibitor><BETi><Back><Body Tissues><Bromodomain><Bromodomain and Extra-Terminal motif inhibitor><Bromodomains and extra-terminal domain inhibitor><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cell Transplantation><Cell-Extracellular Matrix><Cells><Cessation of life><Characteristics><Cicatrix><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Computational algorithm><Cutaneous><Data><Death><Deposit><Deposition><Dermal injury><Development><Differentiation Inhibitor><Dorsal><Dorsum><E1A Binding Protein p300><ECM><EP300><EP300 gene><Embryo><Embryonic><Evaluation><Extracellular Matrix><Extracellular Matrix Proteins><F-Box Domain Protein><F-Box Protein Family><F-Box Proteins><Face><Fiber><Fibroblasts><Fibrosis><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Gene Transcription><Generalized Growth><Genetic Transcription><Growth><Harvest><Heterogeneity><Histologic><Histologically><Histology><Histone Acetylase><Histone Acetylation><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Injury><Intracellular Communication and Signaling><KAT3B><Knock-out><Knockout><Lateral><Light><Measures><Mechanics><Medical><Mesoderm><Mice><Mice Mammals><Molecular><Morbidity><Murine><Mus><Natural regeneration><Neural Crest><Organ><Outcome><Pathway interactions><Pattern><Phenotype><Photoradiation><Process><Proteins><Proteomics><RNA Expression><Regeneration><Regenerative capacity><Regenerative wound healing><Role><Scalp><Scalp structure><Scars><Signal Transduction><Signal Transduction Systems><Signaling><Site><Skin><Skin injury><Skin wound healing><Societies><Somites><Surgical Models><Therapeutic><Tissue Growth><Tissues><Transcription><Transgenic Organisms><Transplantation><United States><Work><Wound Repair><adulthood><biological signal transduction><bromodomain extra-terminal inhibitor><cell type><cellular differentiation><cellular transplant><computer algorithm><cutaneous fibrosis><cutaneous injury><cutaneous wound><cutaneous wound healing><dermal fibrosis><dermal wound><dermal wound healing><develop therapy><developmental><epidermal injury><face skin><faces><facial><facial skin><fibrotic skin><flow cytophotometry><functional loss><healing><histone acetyltransferase><histone acetyltransferase p300><inhibitor><injuries><injuries to skin><intervention development><machine learned algorithm><machine learning algorithm><machine learning based algorithm><mechanic><mechanical><mortality><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><ontogeny><overexpress><overexpression><p300><pathway><prevent><preventing><protein protein interaction><psychosocial outcome><psychosocial sequelae><regenerate><regeneration ability><regeneration capacity><regeneration healing><regenerative><regenerative healing><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skin fibrosis><skin healing><skin wound><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><therapeutic target><therapy development><tissue wound><tool><transgenic><translational goal><translational mission><transplant><transplant model><treat wound><treatment development><treatment strategy><wound><wound healing><wound management><wound recovery><wound resolution><wound therapeutics><wound therapy><wound treatment><wounding><wounds>

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Derrick Wan

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$355,466

FY 2026

Project Title

Reprogramming fibroblasts embryonic origins to overcome skin fibrosis and scarring.

Grant Number:

5R01DE032677-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

7. Project Summary/Abstract Adult human skin heals by developing fibrotic scar tissue, which can result in devastating disfigurement, growth restriction, and permanent functional loss. Despite a plethora of clinical options, no current treatment strategies successfully prevent or reverse this fibrot...

Research Terms

<21+ years old><Abdomen><Accounting><Adult><Adult Human><BET bromodomain inhibitor><BET inhibitor><BETi><Back><Body Tissues><Bromodomain><Bromodomain and Extra-Terminal motif inhibitor><Bromodomains and extra-terminal domain inhibitor><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cell Transplantation><Cell-Extracellular Matrix><Cells><Cessation of life><Characteristics><Cicatrix><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Computational algorithm><Cutaneous><Data><Death><Deposit><Deposition><Dermal injury><Development><Differentiation Inhibitor><Dorsal><Dorsum><E1A Binding Protein p300><ECM><EP300><EP300 gene><Embryo><Embryonic><Evaluation><Extracellular Matrix><Extracellular Matrix Proteins><F-Box Domain Protein><F-Box Protein Family><F-Box Proteins><Face><Fiber><Fibroblasts><Fibrosis><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Gene Transcription><Generalized Growth><Genetic Transcription><Growth><Harvest><Heterogeneity><Histologic><Histologically><Histology><Histone Acetylase><Histone Acetylation><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Injury><Intracellular Communication and Signaling><KAT3B><Knock-out><Knockout><Lateral><Light><Measures><Mechanics><Medical><Mesoderm><Mice><Mice Mammals><Molecular><Morbidity><Murine><Mus><Natural regeneration><Neural Crest><Organ><Outcome><Pathway interactions><Pattern><Phenotype><Photoradiation><Process><Proteins><Proteomics><RNA Expression><Regeneration><Regenerative capacity><Regenerative wound healing><Role><Scalp><Scalp structure><Scars><Signal Transduction><Signal Transduction Systems><Signaling><Site><Skin><Skin injury><Skin wound healing><Societies><Somites><Surgical Models><Therapeutic><Tissue Growth><Tissues><Transcription><Transgenic Organisms><Transplantation><United States><Work><Wound Repair><adulthood><biological signal transduction><bromodomain extra-terminal inhibitor><cell type><cellular differentiation><cellular transplant><computer algorithm><cutaneous fibrosis><cutaneous injury><cutaneous wound><cutaneous wound healing><dermal fibrosis><dermal wound><dermal wound healing><develop therapy><developmental><epidermal injury><face skin><faces><facial><facial skin><fibrotic skin><flow cytophotometry><functional loss><healing><histone acetyltransferase><histone acetyltransferase p300><inhibitor><injuries><injuries to skin><intervention development><machine learned algorithm><machine learning algorithm><machine learning based algorithm><mechanic><mechanical><mortality><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><ontogeny><overexpress><overexpression><p300><pathway><prevent><preventing><protein protein interaction><psychosocial outcome><psychosocial sequelae><regenerate><regeneration ability><regeneration capacity><regeneration healing><regenerative><regenerative healing><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skin fibrosis><skin healing><skin wound><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><therapeutic target><therapy development><tissue wound><tool><transgenic><translational goal><translational mission><transplant><transplant model><treat wound><treatment development><treatment strategy><wound><wound healing><wound management><wound recovery><wound resolution><wound therapeutics><wound therapy><wound treatment><wounding><wounds>

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Ann Mullally

PALO ALTO VETERANS INSTIT FOR RESEARCH, PALO ALTO, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$355,000

FY 2026

Project Title

Functional and Molecular Dissection of Mutant Calreticulin in Myeloproliferative Neoplasms

Grant Number:

5R01HL131835-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/20/2024

End Date:

9/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Although the mechanism by which calreticulin (CALR) mutations cause myeloproliferative neoplasms (MPN) has been elucidated, there is currently a fundamental gap in translating this knowledge into innovative therapeutic strategies. The long-term goal is to advance the treatment of CAL...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><55-kDa High-Affinity Calcium Binding Protein><AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Acute leukemia><Biochemical><Bioinformatics><Biology><Bleeding><Blood Cells><Blood Clotting><Blood Diseases><Blood Grouping><Blood Precursor Cell><Blood Typing><Blood coagulation><Blood typing procedure><Bone Marrow><Bone Marrow Fibrosis><Bone Marrow Reticuloendothelial System><CAB-63><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Calcium-Binding Protein-3><Calregulin><Cas nuclease technology><Cell Body><Cells><Chemicals><Chromatin><Clinic><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><DNA mutation><Data><Dependence><Development><Disease><Disease Progression><Disorder><Dissection><ERp60><Event><FDA approved><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><HACBP><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoietic><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Hemorrhage><Human><In Vitro><JAK-2><JAK2><JAK2 gene><JAK2 protein><Janus kinase 2><KI mice><Knock-in Mouse><Knock-out><Knockout><Knowledge><Macropain><Macroxyproteinase><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Metabolic Glycosylation><Mission><Modern Man><Molecular><Multicatalytic Proteinase><Mutate><Mutation><Myelofibrosis><Myeloid Disease><Myeloid Malignancy><Myeloid Neoplasm><Myeloid Tumor><Myeloproliferative Disorders><Myeloproliferative Tumors><Myeloproliferative disease><Myelosclerosis><NIH><National Institutes of Health><Natural History><Oncogenic><Outcome><Pathway interactions><Patients><Peripheral Blood Cell><Phenotype><Production><Progenitor Cell Transplantation><Prognosis><Property><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteasome Inhibition><Protein Biosynthesis><Protein Secretion><Proteomics><Proteosome><Public Health><Publishing><Reagent><Repression><Research><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Risk><Single cell seq><Stem Cell Transplantation><Stem cell transplant><Testing><Therapeutic><Thrombocythemia><Transcription Activation><Transcriptional Activation><Translating><Tyrosine-Protein Kinase JAK2><United States National Institutes of Health><Work><acute granulocytic leukemia><acute myeloid leukemia><blood cell progenitor><blood disorder><blood loss><blood progenitor><blood stem cell><blood-forming stem cell><cC1qR Protein><calreticulin><curative intervention><curative therapeutic><curative therapy><curative treatments><developmental><entire genome><full genome><functional genomics><genome mutation><global gene expression><global transcription profile><glycosylation><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><histone modification><human disease><in vivo><inhibitor><innovate><innovation><innovative><insight><knockin mice><mouse model><multicatalytic endopeptidase complex><murine model><mutant><myeloproliferative neoplasm><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><palliative><pathway><pharmacologic><progenitor transplantation><prognostic><protein homeostasis><protein synthesis><proteostasis><screening><screenings><single cell next generation sequencing><single cell sequencing><stem and progenitor cell transplantations><thrombocytosis><transcriptome><translational impact><treatment strategy><whole genome>

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JONATHAN A GREEN

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Good lead · 56/100

Above-average budget

Very recent

Active award

Team-scale grant

$886,875

FY 2026

Project Title

Swine Somatic Cell Gene Editing Testing Center (Targeted Challenge)

Grant Number:

3U42OD035738-03S1

Activity Code:

U42

Mechanism:

Research Centers

Agency:

NIH

Start Date:

4/1/2026

End Date:

8/31/2027

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The objective of this supplement project is to perform a side-by-side assessment of various gene editing (GE) formulations to identify those most effective as reagents for tissue editing. The project involves the delivery of CRISPR/Cas9 gene editing ribonucleoprotein complexes intrav...

Research Terms

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Kevin Dale Wells

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Good lead · 56/100

Above-average budget

Very recent

Active award

Team-scale grant

$886,875

FY 2026

Project Title

Swine Somatic Cell Gene Editing Testing Center (Targeted Challenge)

Grant Number:

3U42OD035738-03S1

Activity Code:

U42

Mechanism:

Research Centers

Agency:

NIH

Start Date:

4/1/2026

End Date:

8/31/2027

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The objective of this supplement project is to perform a side-by-side assessment of various gene editing (GE) formulations to identify those most effective as reagents for tissue editing. The project involves the delivery of CRISPR/Cas9 gene editing ribonucleoprotein complexes intrav...

Research Terms

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Anna M. Krichevsky

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 56/100

Above-average budget

Very recent

Active award

Team-scale grant

$790,474

FY 2026

Project Title

miR-10b Gene Editing Therapy for Glioblastoma

Grant Number:

1UG3NS143075-01A1

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Malignant glioma, particularly glioblastoma (GBM), remains among the most lethal forms of cancer and represents a significant unmet need in current medicine. The median survival of GBM patients is approximately 15-20 months with highly aggressive standard care, and the five-year survival ra...

Research Terms

<21+ years old><ASO therapeutics><ASO therapy><ASO treatment><Abscission><Adult><Adult Human><Allografting><Angiogenesis Antagonists><Angiogenesis Blockers><Angiogenesis Inhibitors><Angiogenetic Antagonists><Angiogenetic Inhibitors><Angiogenic Antagonists><Angiogenic Inhibitors><Angiostatic Agents><Animal Model><Animal Models and Related Studies><Animals><Anti-Angiogenetic Agents><Anti-Angiogenic Agents><Anti-Angiogenic Drugs><Anti-VEGF><Anti-VEGF Humanized Monoclonal Antibody><Anti-VEGF RhuMAb><Antiangiogenesis Agents><Antiangiogenic Agents><Antiangiogenic Drugs><Antisense Agent><Antisense Oligonucleotide Therapy><Antisense Oligonucleotides><Apoptosis><Apoptosis Pathway><BCL2L11><BCL2L11 gene><BIM><BIMEL><BIML><BimMEL><Biodistribution><Brain><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><CDK-Interacting Protein 1><CDK4I><CDKN1><CDKN1A><CDKN1A gene><CDKN2><CDKN2 Genes><CDKN2A><CDKN2A gene><CIP1><CMM2><COVID-19><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CV-19><Cancers><Cas nuclease technology><Cell Body><Cell Cycle><Cell Differentiation><Cell Differentiation process><Cell Division Cycle><Cell Protection><Cell model><Cells><Cellular model><Clinical Paths><Clinical Pathways><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Coronavirus Infectious Disease 2019><Cyclin-Dependent Kinase Inhibitor 1A><Cyclin-Dependent Kinase Inhibitor 2A Gene><Cytoprotection><DNA Therapy><DNA mutation><Development><Diagnosis><Disease><Disorder><Dose><Drug Formulations><Drugs><EGF Receptor><EGFR><EGFRvIII Peptide><ERBB Protein><Encephalon><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><Excision><Exhibits><Extirpation><FDA approved><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Formulation><Gene Expression><Gene Transfer Clinical><Generalized Growth><Genes><Genetic Change><Genetic Intervention><Genetic defect><Genetic mutation><Glia><Gliadel><Glial Cell Tumors><Glial Cells><Glial Neoplasm><Glial Tumor><Glioblastoma><Glioma><Gliomagenesis><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Growth><Guidelines><HER1><Heterograft><Heterologous Transplantation><Human><IND Filing><IND application><IND package><IND submission><INK4><INK4A><Immune mediated therapy><Immunocompetent><Immunologically Directed Therapy><Immunotherapy><Invaded><Investigational New Drug Application><Kolliker's reticulum><Lead><MTS1><MTS1 Genes><Malignant Glial Neoplasm><Malignant Glial Tumor><Malignant Glioma><Malignant Neoplasms><Malignant Neuroglial Neoplasm><Malignant Neuroglial Tumor><Malignant Tumor><Mediating><Medication><Medicine><Messenger RNA><Mice><Mice Mammals><MicroRNAs><MoAb VEGF><Modeling><Modern Man><Molecular Target><Monoclonal Antibody Anti-VEGF><Murine><Mus><Mutation><Neovascularization Inhibitors><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neuroglial Neoplasm><Neuroglial Tumor><Neurons><Newly Diagnosed><Non-neuronal cell><Nonneuronal cell><Organoids><PK/PD><Patients><Pb element><Peptide Vaccines><Pharmaceutical Preparations><Phase><Play><Programmed Cell Death><RNA Splicing><RNA delivery><RNA vaccine><RNA-based vaccine><Recombinant Humanized Anti-VEGF Monoclonal Antibody><Recombinant Humanized Monoclonal Antibody to Vascular Endothelial Growth Factor><Recurrence><Recurrent><Regimen><Removal><Research Contracts><Resistance><RhuMAb VEGF><Rodent><Rodentia><Rodents Mammals><Role><Safety><Schedule><Signal Pathway><Splicing><Surgical Removal><Survival Rate><System><TGF-alpha Receptor><TP16><TSG9A><Temodal><Temodar><Testing><Therapeutic><Therapeutic Gene Editing><Tissue Growth><Toxic effect><Toxicities><Toxicology><Transcription Activation><Transcriptional Activation><Transforming Growth Factor alpha Receptor><Tumor Cell Nuclei><Tumor Subtype><U6 RNA><U6 small nuclear RNA><U6 snRNA><Urogastrone Receptor><WAF1><Wildtype p53-Activated Fragment 1><Work><Writing><Xenograft><Xenograft procedure><Xenotransplantation><addiction><addictive disorder><adulthood><anti-sense oligonucleotide drug><anti-sense oligonucleotide therapy><anti-sense oligonucleotide treatment><anti-sense therapy><antiangiogenic><antisense drug><antisense oligo><antisense oligonucleotide therapeutic><antisense therapeutics><antisense therapy><bevacizumab><c-erbB-1><c-erbB-1 Protein><cellular differentiation><check point inhibition><checkpoint inhibition><chemo-/radio-therapy><chemo-radiotherapy><chemoradiation><chemoradiation therapy><chemoradiation treatment><chemoradiotherapy><chemotherapy><clinical lot><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><cytoprotective><developmental><disease heterogeneity><drug development><drug/agent><effective therapy><effective treatment><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><first in man><first-in-human><gene repair therapy><gene therapy><gene-based therapy><gene-editing therapy><genetic therapy><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genome mutation><genomic therapy><glial-derived tumor><glioblastoma multiforme><glioma genesis><heavy metal Pb><heavy metal lead><immune check point inhibition><immune checkpoint inhibition><immune competent><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><improve symptom><in vivo><inhibitor><lipid based nanoparticle><lipid nanoparticle><mRNA><mRNA vaccine><mRNA-based vaccine><malignancy><manufacture><methazolastone><miRNA><model of animal><mouse model><murine model><mutational status><neoplasm/cancer><nerve cement><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neuro-oncology><neurogenic progenitors><neurogenic stem cell><neuroglia neoplasm><neuroglia tumor><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neurooncology><neuroprogenitor><neurosurgery><oligonucleotide drug><oligonucleotide therapeutics><oligonucleotide therapies><oligonucleotide treatment><ontogeny><p14ARF><p16 Genes><p16INK4 Genes><p16INK4A Genes><p16INK4a><p21 gene><p21 protein><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><pharmacokinetics and pharmacodynamics><pre-clinical><precision medicine><precision-based medicine><preclinical><pro-apoptotic protein><progenitor and neural stem cells><proto-oncogene protein c-erbB-1><radio-chemo-therapy><radio-chemotherapy><radiochemotherapy><resection><resistant><rhuMabVEGF><social role><spongioblastoma multiforme><standard care><standard of care><standard treatment><success><symptom improvement><symptomatic improvement><targeted drug therapy><targeted drug treatments><targeted drug trials><targeted pharmaceutical trials><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted therapy trials><targeted treatment><targeted treatment trials><technology platform><technology system><temozolomide><therapeutic editing><therapeutic genome editing><therapeutic target><tumor><tumor growth><tumors in the brain><uncontrolled cell growth><uptake><xeno-transplant><xeno-transplantation>

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Yun Young Yim

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$177,606

FY 2026

Project Title

From synapse to function: cocaine-induced cell-type- and circuit-specific accumbal proteome changes

Grant Number:

5K01DA060334-02

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Projection Summary/Abstract Substance use disorders remain a major public health issue in the US and have proven exceptionally difficult to treat due to their complex neurobiological underpinnings. Dysregulated signaling within the nucleus accumbens (NAc) appears to play a critical role in promoting...

Research Terms

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Xiaoyun Ding

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$120,902

FY 2026

Project Title

Mechanisms of axoglial interactions at the paranodal junction

Grant Number:

1K99EY037780-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY. Proper CNS function requires intricate axon-glia interactions. In the optic nerve, for example, each myelinating oligodendrocyte (OL) physically contacts up to 60 axons, forming the largest intercellular junction in vertebrates - the paranodal junction (PNJ). The PNJ anchors the my...

Research Terms

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JACQUELYN J. MAHER

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 54/100

Large award

Very recent

Active award

$1,614,997

FY 2026

Project Title

Establishing patient-derived iPSCs as a platform for discovery research in NAFLD

Grant Number:

5RC2DK136052-04

Activity Code:

RC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Our research group studies human NAFLD using patient-derived induced pluripotent stem cells (iPSCs) for in vitro disease modeling. We recently showed that iPSCs from a cohort of NAFLD patients, when differentiated to hepatocytes (iPSC-Heps), display a spontaneous disease sig...

Research Terms

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Aras Nikodemas Mattis

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 54/100

Large award

Very recent

Active award

$1,614,997

FY 2026

Project Title

Establishing patient-derived iPSCs as a platform for discovery research in NAFLD

Grant Number:

5RC2DK136052-04

Activity Code:

RC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Our research group studies human NAFLD using patient-derived induced pluripotent stem cells (iPSCs) for in vitro disease modeling. We recently showed that iPSCs from a cohort of NAFLD patients, when differentiated to hepatocytes (iPSC-Heps), display a spontaneous disease sig...

Research Terms

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Holger Willenbring

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 54/100

Large award

Very recent

Active award

$1,614,997

FY 2026

Project Title

Establishing patient-derived iPSCs as a platform for discovery research in NAFLD

Grant Number:

5RC2DK136052-04

Activity Code:

RC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Our research group studies human NAFLD using patient-derived induced pluripotent stem cells (iPSCs) for in vitro disease modeling. We recently showed that iPSCs from a cohort of NAFLD patients, when differentiated to hepatocytes (iPSC-Heps), display a spontaneous disease sig...

Research Terms

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ANGELIKA DOETZLHOFER

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 52/100

Likely hiring

Solid budget

Active award

$484,777

FY 2026

Project Title

The function of LIN28B and follistatin in supporting cell reprogramming and hair cell regeneration in the murine cochlea

Grant Number:

5R01DC019359-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2021

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project summary Our proposed study aims to address the function of LIN28B and follistatin in supporting cell reprogramming and hair cell regeneration in the murine cochlea. Loss of auditory hair cells (HCs) due to disease or trauma is permanent and is a leading cause for hearing impairments and deaf...

Research Terms

<21+ years old><Ablation><Activin-Binding Protein><Activins><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Alleles><Allelomorphs><Assay><Attenuated><Auditory><BSC-1 Cell Growth Inhibitor><Bioassay><Biological Assay><CIF-B><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cartilage-Inducing Factor-B><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Reprogramming><Cell Signaling><Cells><Cellular Proliferation><Cellular injury><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cochlea><Cochlear Organ><Corti Cell><Corynebacterium Diphtheriae Toxin><Cre Lox technology><Cre LoxP system><Cre lox recombination><Cre lox recombination system><Cre lox system><Cre recombinase/LoxP technology><Cre system><Cues><Data><Diphtheria Toxin><Disease><Disorder><Doxycycline><Ear><Expression Signature><FISH Technic><FISH Technique><FISH analysis><FISH assay><FSH-Releasing Protein><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Follistatin><GSC-1GI><Gene Expression Profile><Generations><Genes><Glioblastoma-Derived T-Cell Suppressor Factor><Hair Cells><Hearing><Hearing Loss><Human><Hypoacuses><Hypoacusis><In Vitro><Internal Ear><Intracellular Communication and Signaling><Knock-out><Knockout><Labyrinth><LoxP-flanked allele><Mediating><Mice><Mice Mammals><Mitotic><Modern Man><Murine><Mus><Natural regeneration><Neonatal><Organoids><Persons><Polyergin><Publishing><RNA-Binding Proteins><Regeneration><Regenerative capacity><Regenerative response><Role><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell like><Supporting Cell><TGF-Beta 2><TGF-Beta2><TGF-b2><TGF-β2><Testing><Therapeutic><Transforming Growth Factor Beta 2><Transgenes><Transgenic Mice><Transgenic Organisms><Trauma><Upregulation><Vibramycin><adult animal><adulthood><alpha-6-Deoxyoxytetracycline><antagonism><antagonist><attenuate><attenuates><biological signal transduction><candidate selection><cell damage><cell dedifferentiation><cell determination><cell injury><cellular damage><cellular reprogramming><cochlear development><damage to cells><deafness><dysfunctional hearing><ear hair cell><experiment><experimental research><experimental study><experiments><floxed><floxed allele><gene expression pattern><gene expression signature><gene function><gene network><global gene expression><global transcription profile><hair cell regeneration><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><hearing restoration><in vitro Model><in vivo><in vivo regeneration><induced Cre><inducible Cre><injury to cells><inner ear><insight><juvenile><juvenile human><mature animal><mouse genetics><mouse model><murine model><neonatal mice><notch><notch protein><notch receptors><novel><overexpress><overexpression><paralog><paralogous gene><pluripotency><pluripotent state><progenitor><progenitor capacity><progenitor cell like><progenitor-like><progenitor-like cell><programs><regenerate><regeneration ability><regeneration capacity><regeneration response><regenerative><repair strategy><response><restore hearing><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single molecule><single-cell RNA sequencing><social role><sound><stem cell characteristics><stem-like><stem-like cell><stemness><tool><transcriptional profile><transcriptional signature><transcriptome><transforming growth factor beta2><transforming growth factor β2><transgene><transgenic>

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DAVID J BEGUN

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$483,000

FY 2026

Project Title

Evolutionary and functional genomics of genetic novelties and expression adaptation in Drosophila

Grant Number:

5R35GM156525-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/10/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Adaptive transcriptome evolution likely underlies a substantial component of all adaptations. Here I propose to study two main types of transcriptome evolution using Drosophila. First, we will identify transcriptome novelties in Drosophila melanogaster, focusing on reproductive tissues. We will then...

Research Terms

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Sandy S Chang

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 52/100

Likely hiring

Solid budget

Active award

$461,313

FY 2026

Project Title

Mechanisms regulating telomere length, protection and replication

Grant Number:

5R35GM156405-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/21/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Telomeres are TTAGGG repetitive DNA-protein complexes at chromosome ends required to solve three significant problems critical for the maintenance of genome stability. The “end replication problem” is due to the inability of DNA polymerase to completely copy the lagging strand of chr...

Research Terms

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Victor Lopez del Amo

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

Good lead · 52/100

Likely hiring

Solid budget

Active award

$455,157

FY 2026

Project Title

Advancing CRISPR-Based Genome Editing Strategies for managing Aedes aegypti mosquito populations

Grant Number:

5R01AI187493-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/13/2024

End Date:

10/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Several viruses such as yellow fever, Zika, Chikungunya, and dengue affect millions of people, causing over 300,000 deaths every year. These viruses are vectored through Aedes mosquito bites, transmitting the pathogens between people. The use of insecticides to kill mosquito...

Research Terms

<A. aegypti><Address><Ades aegypti><Ae. Aegypti><Aedes><Aedes aegypti><Affect><Alleles><Allelomorphs><Biomedical Research><Bite><CRISPR><CRISPR gene drive><CRISPR-Cas9 gene drive><CRISPR-Cas9 mediated gene drive><CRISPR/Cas system><CRISPR/Cas9 based gene drive><Cannot achieve a pregnancy><Cas9-based gene drive><Cessation of life><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats gene drive><Communities><Consumption><Country><Crossbreeding><Culicidae><DNA mutation><Data><Death><Dengue><Dengue Fever><Dengue disease><Difficulty conceiving><Disease><Disease Management><Disease Outbreaks><Disease Vectors><Disorder><Disorder Management><Economic Burden><Elements><Endemic Diseases><Engineering><Environment><Female><Future><Generations><Genes><Genetic><Genetic Change><Genetic Crosses><Genetic Hybridization><Genetic defect><Genetic mutation><Guide RNA><Health><High temperature of physical object><Human><Incidence><Infertility><Insecta><Insecticides><Insects><Insects Invertebrates><Investigation><Laboratories><Maintenance><Malaria><Male Sterility><Modern Man><Modification><Mosquito Control><Mosquitoes><Mutation><Outbreaks><Paludism><Partner in relationship><Pathology><Persons><Pest Control><Pesticides><Plasmodium Infections><Population><Population Control><Population Study><Preparedness><Process><Production><Public Health><Readiness><Resistance><Site><System><Technology><Temperature><Testing><Time><Transgenes><Transgenic Organisms><Transmission><Vaccines><Virus><Yellow Fever><ZIKA><ZIKV fever><Zika virus fever><antibody engineering><breakbone fever><chikungunya><cold temperature><combat><design><designing><egg><experiment><experimental research><experimental study><experiments><fertility cessation><fertility loss><fighting><gRNA><gene drive approach><gene drive strategy><gene drive system><gene drive technology><gene editing platform><gene editing system><gene editing technology><gene editing tools><gene-editing toolkit><genetic approach><genetic strategy><genome editing><genome mutation><genomic editing><high temperature><human disease><improved><indel><infertile><insertion/deletion><insertion/deletion mutation><insight><low temperature><male><mate><new technology><next-generation gene drive><novel><novel technologies><nuclease><pathogen><population research study><population survey><population-based study><population-level study><prevent><preventing><repair><repaired><resistance allele><resistant><resistant allele><response><sex><sterile insect technique><tool><trait><transgene><transgenic><transmission process><vector><vector control><vector mosquito><zika fever><♀><♂>

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Ravindra Majeti

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$443,413

FY 2026

Project Title

Functional Interrogation of Human Acute Myeloid Leukemia Stem Cells

Grant Number:

5R01CA288731-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Studies over the last several decades have led to a model that human AML is organized as a cellular hierarchy initiated and maintained by self-renewing leukemia stem cells (LSCs). The lack of functional studies has limited the understanding of human AML LSCs and the utility of this s...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AML - Acute Myeloid Leukemia><APAF-3><APAF3><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Adult><Adult Human><Affect><Aged 65 and Over><Allogenic><Apaf-3 protein><Apoptosis><Apoptosis Pathway><Apoptosis-Related Cysteine Protease Caspase 9><Apoptosis-Related Cysteine Protease Gene Caspase 9><Apoptotic Protease Activating Factor 3><Apoptotic Protease Activating Factor 3 Gene><Apoptotic Protease MCH-6><Apoptotic Protease MCH-6 Gene><B23><Bar Codes><Blood><Blood Reticuloendothelial System><Bone Marrow><Bone Marrow Reticuloendothelial System><CASP-9><CASP9><CASP9 Protein><CASP9 gene><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancers><Cas nuclease technology><Caspase-9 Gene><Cell Body><Cells><Chromatin><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><DNA mutation><DNMT3a><Data><Development and Research><Disease><Disorder><Engineering><Engraftment><Frequencies><Gene Expression><Genes><Genetic Change><Genetic defect><Genetic mutation><Genome><Genome engineering><Genomics><HSC transplantation><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Heterogeneity><Heterograft><Heterologous Transplantation><High Dose Chemotherapy><Human><ICE-LAP6><ICE-LAP6 Gene><ICE-LAP6 protein><ICE-Like Apoptotic Protease 6><ICE-Like Apoptotic Protease 6 Gene><Individual><Leukemic progenitor and stem cell><Lineage Tracing><MCH6><Maintenance><Malignant Neoplasms><Malignant Tumor><Mch6 protein><Mediating><Methods><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Murine><Mus><Mutation><Myeloid Cells><NPM><NPM1><NPM1 gene><Non-Polyadenylated RNA><Patients><Population><Programmed Cell Death><Property><Proteins><R & D><R&D><RNA><RNA Gene Products><Recombinant adeno-associated virus><Recombinant adeno-associated virus (rAAV)><Relapse><Resolution><Ribonucleic Acid><Sampling><Stem Cell Research><Therapeutic><Translational Research><Translational Science><Transplantation><United States><Xenograft><Xenograft procedure><Xenotransplantation><above age 65><acute granulocytic leukemia><acute granulocytic leukemia cell><acute myeloblastic leukemia cell><acute myelocytic leukemia cell><acute myelogenous leukemia cell><acute myeloid leukemia><acute myeloid leukemia cell><acute nonlymphocytic leukemia cell><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><aggressive therapy><aggressive treatment><barcode><blood stem cell transplantation><caspase-9><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><genome mutation><hDNA methyltransferase 3a><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><human old age (65+)><iPS><iPSC><iPSCs><in vivo><in vivo engraftment><induced Cre><induced pluripotent cell><induced pluripotent stem cell><inducible Cre><inducible pluripotent cell><inducible pluripotent stem cell><leukemia><leukemia stem/initiating cells><leukemia treatment><leukemic progenitor><leukemic stem cell><leukemic therapy><malignancy><mitochondrial><mutation correction><neoplasm/cancer><novel><over 65 years><progenitor biology><progenitor cell biology><progenitor cell model><progenitor model><rAAV><recombinant AAV><repair><repaired><research and development><resolutions><response to therapy><response to treatment><scATAC sequencing><scATAC-seq><self-renew><self-renewal><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell sequencing assay for transposase accessible chromatin><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><standard of care><stem and progenitor biology><stem and progenitor cell model><stem cell based model><stem cell biology><stem cell depletion><stem cell derived model><stem cell exhaustion><stem cell fatigue><stem cell model><stem cell study><therapeutic response><therapy response><translation research><translational investigation><translational model><translational study><transplant><treatment response><treatment responsiveness><xeno-transplant><xeno-transplantation><≥65 years>

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Denis Vasilievich Titov

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$441,375

FY 2026

Project Title

Toward a quantitative understanding of metabolic homeostasis

Grant Number:

5R35GM152114-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project summary/abstract The long-term goal of my research is to understand how the kinetic and thermodynamic properties of enzymes maintain metabolic homeostasis. The function of metabolic homeostasis is to maintain appropriate levels of ATP and biosynthetic precursors. Understanding metabolic hom...

Research Terms

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Xiaodong Cheng

TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, COLLEGE STATION, TX

Good lead · 52/100

Likely hiring

Solid budget

Active award

$435,931

FY 2026

Project Title

Mutual reinforcement between somatic mutations and transcription factors in clonal hematopoiesis

Grant Number:

5R01DK132286-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/ Abstract Recent highthroughput exome sequencing has revealed various somatic mutations in individuals with clonal hematopoiesis (CH) and myelodysplastic syndromes (MDS) patients. Among these mutations, C-to-T mutations is among the most common type of single mutations observed in CH...

Research Terms

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Yun Huang

TEXAS A&M UNIVERSITY HEALTH SCIENCE CTR, COLLEGE STATION, TX

Good lead · 52/100

Likely hiring

Solid budget

Active award

$435,931

FY 2026

Project Title

Mutual reinforcement between somatic mutations and transcription factors in clonal hematopoiesis

Grant Number:

5R01DK132286-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/ Abstract Recent highthroughput exome sequencing has revealed various somatic mutations in individuals with clonal hematopoiesis (CH) and myelodysplastic syndromes (MDS) patients. Among these mutations, C-to-T mutations is among the most common type of single mutations observed in CH...

Research Terms

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WENDY RYAN GORDON

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 52/100

Likely hiring

Solid budget

Active award

$422,872

FY 2026

Project Title

Decoding mechanotransduction mechanisms of cell-surface receptors

Grant Number:

5R35GM119483-10

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/20/2016

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Recently, it has become apparent that mechanical cues in the cellular microenvironment drive cell migration, stem cell differentiation into distinct cell types and even how a surveilling T-cells is triggered by its correct antigen, solidifying tension-sensing as a key regulatory swit...

Research Terms

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Amanda Marie Larracuente

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 52/100

Likely hiring

Solid budget

Active award

$421,050

FY 2026

Project Title

The evolutionary and functional genomics of satellite DNA

Grant Number:

5R35GM119515-10

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2016

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project summary Eukaryotic genomes contain arrays of tandemly repeated non-coding sequences that we currently know little about—satellite DNAs. Typically found near centromeres, telomeres, and on Y chromosomes, satellite DNAs can comprise over 50% of some eukaryotic genomes. They are known to change...

Research Terms

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ERIKS ROZNERS

STATE UNIVERSITY OF NY,BINGHAMTON, BINGHAMTON, NY

Good lead · 52/100

Likely hiring

Solid budget

Active award

$418,548

FY 2026

Project Title

Chemical Approaches to Control the Function of Regulatory RNAs

Grant Number:

5R35GM130207-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2019

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Recent decades have dramatically changed our view of RNA. While RNA was initially believed to be barely a passive messenger in the transfer of genetic information from DNA to proteins, it is now clear that RNA is an exciting and underexplored regulatory molecule that will continue to deliver new dis...

Research Terms

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Hiten D Madhani

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$415,863

FY 2026

Project Title

Mechanisms of Gene Expression

Grant Number:

5R01GM071801-20

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2005

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT Most of understanding of how the spliceosome operates in vivo comes from studies of mutants in S. cerevisiae, yet human splicing displays major differences, including massive variation in length, much more variable intron signals, numerous additional subunits in the spliceosome, and much mo...

Research Terms

<3' Splice Site><Alleles><Allelomorphs><Amino Acids><Assay><Baker's Yeast><Binding><Bioassay><Biological Assay><Brewer's Yeast><C-terminal><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancers><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cells><Chicago><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><Conserved Sequence><Cytosine><DNA Helicases><DNA Unwinding Proteins><DNA mutation><DNA unwinding enzyme><Decision Making><Family><Gene Expression><GeneHomolog><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetic study><Genotoxins><Goals><Hand><Haploid><Haploid Cells><Haploidy><Homolog><Homologous Gene><Homologue><Human><In Vitro><Individual><Intervening Sequences><Intracellular Communication and Signaling><Introns><Isoforms><L-Proline><Label><Lead><Length><Malignant Neoplasms><Malignant Tumor><Methods><Missense Mutation><Modern Man><Molecular><Molecular Interaction><Mutagens><Mutate><Mutation><Pb element><Phenotype><Point Mutation><Pre-mRNA><Proline><Protein Isoforms><Proteins><RNA Seq><RNA Splicing><RNA sequencing><RNA, Messenger, Precursors><RNA-Binding Proteins><RNAseq><Reagent><Regulation><Reporter><Reporter Genes><Resistance><Ribonucleoproteins><Ribonucleoproteins, Small, U2><Role><S cerevisiae><S. cerevisiae><Saccharomyces cerevisiae><Signal Transduction><Signal Transduction Systems><Signaling><Site><Splice Acceptor Sites><Spliceosomes><Splicing><Strains Cell Lines><System><Testing><U1 small nuclear ribonucleoprotein A><U1 snRNP protein A><U1A protein><U2 Small Nuclear Ribonucleoprotein><U2 snRNP><Validation><Variant><Variation><Work><Yeasts><aminoacid><base editing><biological signal transduction><computer based prediction><cost><cultured cell line><design><designing><experiment><experimental research><experimental study><experiments><flexibility><flexible><forward genetics><genetic approach><genetic strategy><genome mutation><genotoxic agent><hands><heavy metal Pb><heavy metal lead><helicase><improved><in vivo><inhibitor><mRNA Precursor><malignancy><member><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><molecular phenotype><mutant><mutation scanning><mutation screening><neoplasm/cancer><predictive modeling><preference><programs><resistance mutation><resistant><resistant mutation><social role><transcriptome sequencing><transcriptomic sequencing><validations>

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Carolyn Sarah McBride

PRINCETON UNIVERSITY, Princeton, NJ

Good lead · 52/100

Likely hiring

Solid budget

Active award

$405,000

FY 2026

Project Title

Molecular and functional characterization of olfactory pathways in the arbovirus vector mosquito Aedes aegypti

Grant Number:

5R01AI175490-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/2/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Abstract Mosquitoes infect hundreds of millions of people with deadly pathogens every year. Since mosquitoes identify humans and other important resources primarily via their sense of smell, the disruption of mosquito olfactory systems has long been recognized as a potential strategy...

Research Terms

<A. aegypti><Acceleration><Ades aegypti><Ae. Aegypti><Aedes aegypti><Afferent Neurons><Arboviral><Arboviruses><Area><Arthropod-Borne Viruses><Axon><Basal Transcription Factor><Basal transcription factor genes><Behavior><Blossoms><Brain><Brain Nervous System><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Nucleus><Chemicals><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Culicidae><Data><Detection><Disease Vectors><Drosophila><Drosophila genus><Encephalon><Equation><Female><Flowers><Gene Library><General Transcription Factor Gene><General Transcription Factors><Genetic><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Human Bites><Image><Individual><Label><Ligands><Lobe><Logic><Maps><Maxilla><Modern Man><Molecular><Mosquito Control><Mosquito-borne disease><Mosquito-borne infectious disease><Mosquitoes><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nucleus><Odors><Olfaction><Olfactory Pathways><Olfactory system><Oviposition><Pattern><Peripheral><Persons><Plant Blooms><Population><Property><Reagent><Receptor Protein><Research><Research Resources><Resolution><Resources><Sensory Neurons><Single-Nucleus Sequencing><Site><Smell><Smell Perception><Sorting><Stop Codon><Technology><Termination Codon><Terminator Codon><Transcription Factor Proto-Oncogene><Transcription factor genes><Translation Stop Signal><Volatilization><Work><cell type><design><designing><experiment><experimental research><experimental study><experiments><flexibility><flexible><fruit fly><genetic library><genome editing><genomic editing><global gene expression><global transcription profile><imaging><in vivo><lobes><maxillary><neural><neuronal><odor perception><olfactory circuitry><olfactory circuits><olfactory perception><olfactory receptor><olfactory sensory neurons><pathogen><rational design><receptor><resolutions><response><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><tool><transcription factor><transcriptome><vector control><vector mosquito><vinegar fly><♀>

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Baljit Khakh

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$393,750

FY 2026

Project Title

Functions and mechanisms of a subpopulation of striatal astrocytes

Grant Number:

5R01MH134926-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT Astrocytes are ubiquitous CNS glial cells that make extensive contacts with neurons. Astrocytes serve diverse roles, including ion homeostasis, neurotransmitter clearance, synapse formation/removal, synaptic modulation, and contributions to neurovascular coupling. Astrocytes are widely impl...

Research Terms

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Elizabeth Kellogg

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

Good lead · 52/100

Likely hiring

Solid budget

Active award

$382,200

FY 2026

Project Title

Structural Basis of Programmable DNA-Insertion via Cryo-EM Studies of CRISPR-Associated TnsC

Grant Number:

5R01GM144566-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Recently, new macromolecular systems have been discovered which marries the benefits of both CRISPR and TNP systems and shows tremendous promise as programmable DNA-insertion tools for genome-editing, complementing the power of tools such as CRISPR-Cas9. This proposal aims to uncove...

Research Terms

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Rebecca A Butcher

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 52/100

Likely hiring

Solid budget

Active award

$381,250

FY 2026

Project Title

Small-molecule signals controlling nematode development

Grant Number:

5R35GM144076-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2021

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract The nematode Caenorhabditis elegans relies on small-molecule signals to control its development, metabolism, physiology, and behavior, and these signals play conserved roles in many parasitic nematode species. This MIRA application outlines our ongoing efforts to understand ...

Research Terms

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Philipp W Messer

CORNELL UNIVERSITY, ITHACA, NY

Good lead · 52/100

Likely hiring

Solid budget

Active award

$377,739

FY 2026

Project Title

Population genetics of rapid evolutionary processes

Grant Number:

5R35GM152242-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary. Rapid evolution lies at the core of some of the greatest challenges humanity faces today, ranging from the evolution of drug and antibiotic resistance to the rapid emergence of new Covid variants. Researchers are now envisioning even faster evolutionary dynamics brought about by CRI...

Research Terms

<2019-nCoV variant><2019-nCoV variant forms><2019-nCoV variant strains><Address><Affect><Alleles><Allelomorphs><Antibiotic Resistance><Biological><COVID-19 variant><COVID-19 variant forms><COVID-19 variant strains><CRISPR gene drive><CRISPR-Cas9 gene drive><CRISPR-Cas9 mediated gene drive><CRISPR/Cas9 based gene drive><Cas9-based gene drive><Clustered Regularly Interspaced Short Palindromic Repeats gene drive><Computational toolkit><Culicidae><Dengue><Development><Disease><Disorder><Drug resistance><Engineering><Evaluation><Evolution><Face><Genes><Genetic><Genetic Models><Goals><Humanities><Individual><Investigators><Malaria><Methods><Modeling><Mosquitoes><Outcome><Paludism><Partner in relationship><Plasmodium Infections><Population><Population Dynamics><Population Genetics><Process><Research><Research Personnel><Researchers><Resistance to antibiotics><Resistant to antibiotics><Risk><SARS-CoV-2 variant><SARS-CoV-2 variant forms><SARS-CoV-2 variant strains><Structure><Target Populations><Transgenes><Transmission><Vector-borne disease><Vector-borne infectious disease><Vector-transmitted disease><Vector-transmitted infectious disease><Work><antibiotic drug resistance><antibiotic resistant><biologic><computational toolbox><computational tools><computational toolset><computerized tools><coronavirus disease 2019 variant><coronavirus disease 2019 variant forms><coronavirus disease 2019 variant strains><developmental><drug resistant><faces><facial><fascinate><gene drive approach><gene drive strategy><gene drive system><gene drive technology><genomic data><genomic dataset><improved><insight><mate><new approaches><new technology><next-generation gene drive><novel approaches><novel strategies><novel strategy><novel technologies><outcome prediction><pathogen><real world application><resistance to Drug><resistant to Drug><severe acute respiratory syndrome coronavirus 2 variant><severe acute respiratory syndrome coronavirus 2 variant forms><severe acute respiratory syndrome coronavirus 2 variant strains><simulation><supervised learning><supervised machine learning><transgene><transmission process><vector><vector control><vector mosquito><vector-borne illness><vectorborne disease><vectorborne illness><vectorborne infectious disease>

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Joseph E Peters

CORNELL UNIVERSITY, ITHACA, NY

Good lead · 52/100

Likely hiring

Solid budget

Active award

$372,889

FY 2026

Project Title

CRISPR-Cas-directed transposition in Tn7-like elements

Grant Number:

5R35GM152260-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary / Abstract Transposons are mobile genetic elements that provide an important mechanism for the acquisition of pathogenesis functions and antibiotic resistance in bacteria. A family of these elements, Tn7 and Tn7- like elements, tightly control transposition allowing them to be parti...

Research Terms

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JUNWEI SHI

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$372,301

FY 2026

Project Title

Investigating novel synthetic lethal epigenetic interactions in Acute Myeloid Leukemia

Grant Number:

5R01CA258904-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/13/2021

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract Acute myeloid leukemia (AML) is a hematopoietic malignancy characterized by aberrant self-renewal and blocked differentiation of myeloid progenitor cells. Many of the oncogenic drivers of AML converge in dysregulation of epigenetic and transcriptional regulation pathways, ge...

Research Terms

<2-Oxoglutarate 5-Dioxygenase Procollagen-Lysine><AML - Acute Myeloid Leukemia><Acetyltransferase><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><Arginine><Assay><BRG-1><BRG-1 Gene><BRG1><BRG1 Gene><BRM/SWI2-Related Gene-1><Bioassay><Biological><Biological Assay><Bromodomain><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer cell line><Cancers><Candidate Disease Gene><Candidate Gene><Cas nuclease technology><Cell Line><CellLine><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Chromosomal dislocation><Chromosomal translocation><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collagen Lysyl Hydroxylase><Collection><Complement><Complement Proteins><Complementary DNA><Complex><Data><Dependence><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Essential Genes><Family><GEM model><GEMM model><Gene Transcription><Generalized Growth><Genes><Genetic><Genetic Screening><Genetic Transcription><Genetic Translocation><Genetically Engineered Mouse><Goals><Growth><Hematopoietic Cell Tumor><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Histone Acetylase><Histones><Human Cell Line><In Vitro><Knock-out><Knockout><Knowledge><L-Arginine><L-Lysine><Lead><Lysine><Lysine 2-Oxoglutarate Dioxygenase><Lysine Hydroxylase><Lysyl Hydroxylase><Maintenance><Malignant><Malignant - descriptor><Malignant Hematopoietic Neoplasm><Malignant Neoplasms><Malignant Tumor><Masks><Mating Type Switching/Sucrose Nonfermenting Protein><Mediating><Methods><Modification><Molecular><Mouse Cell Line><Myeloid Cells><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><Non-Polyadenylated RNA><Oncogenic><PDX model><Pathogenesis><Pathway interactions><Patient derived xenograft><Patients><Pb element><Phenotype><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Proliferating><Protein Modification><Proteins><Protocollagen Lysyl Hydroxylase><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Reader><Regulation of transcriptional activity by PML><Ribonucleic Acid><Role><SMARCA4><SMARCA4 gene><SNF2-Beta><SWI/SNF Complex><SWI/SNF Family Complex><SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 4 Gene><Scanning><Strains Cell Lines><Stress><Therapeutic><Therapeutically Targetable><Tissue Growth><Transcription><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcription Regulation Pathway><Transcriptional Activator/Coactivator><Treatment Efficacy><Tumor Cell><acute granulocytic leukemia><acute granulocytic leukemia cell><acute myeloblastic leukemia cell><acute myelocytic leukemia cell><acute myelogenous leukemia cell><acute myeloid leukemia><acute myeloid leukemia cell><acute nonlymphocytic leukemia cell><biologic><blood cancer><cDNA><cancer of blood><cancer of the blood><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chromatin modification><chromatin remodeling><chromosome dislocation><chromosome translocation><combinatorial><complementation><cultured cell line><epigenetic regulation><epigenetically><expression subtypes><genetically engineered mouse model><genetically engineered murine model><heavy metal Pb><heavy metal lead><histone acetyltransferase><improved><in vivo><inhibitor><innovate><innovation><innovative><insight><intervention efficacy><leukemia><malignancy><molecular sub-types><molecular subsets><molecular subtypes><mouse model><murine model><mutant><myeloid precursor><myeloid stem and progenitor cell><neoplasm/cancer><neoplastic cell><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><ontogeny><overexpress><overexpression><pathway><patient derived xenograft model><programs><protein complex><screening><screenings><self-renew><self-renewal><social role><synthetic lethal interaction><synthetic lethality><therapeutic efficacy><therapeutic target><therapy efficacy><transcriptome sequencing><transcriptomic sequencing><transcriptomics>

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HOSHANG JEHANGIR UNWALLA

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Good lead · 52/100

Likely hiring

Solid budget

Active award

$368,034

FY 2026

Project Title

A CRISP(e)R way to silence HIV

Grant Number:

5R01AI174269-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/14/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY: In aging HIV-infected populations comorbid diseases are important determinants of morbidity and mortality. HIV patients die of non-AIDS comorbidities almost a decade earlier that their non-HIV counterparts. cART is unable to eradicate HIV due to established HIV reservoirs. Mounting...

Research Terms

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Eduardo Molina Jijon

RUSH UNIVERSITY MEDICAL CENTER, CHICAGO, IL

Good lead · 52/100

Likely hiring

Solid budget

Active award

$343,650

FY 2026

Project Title

Hodgkin’s Lymphoma-induced Nephrotic Syndrome

Grant Number:

5R01DK141612-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY / ABSTRACT (max 30 lines) Hodgkin Lymphoma (HL) is a malignant condition most prevalent in adolescents and young adults (3 new cases per 100,000 individuals per year). About 0.5 to 1% of HL patients develop nephrotic syndrome (NS). Hodgkin Reed–Sternberg (HRS) cells, representing about 1% of...

Research Terms

<(TNF)-α><A-152E5.3><ABCD-2><ABCD-2 protein><Acute Nasopharyngitis><Adolescent and Young Adult><Albuminuria><Antibodies><Atopic Allergy><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cells><B-Lymphocytes><B-cell><BALB C Mouse><BALB/c><BALB/cJ Mouse><BCDF><BSF-2><BSF2><Blood><Blood Reticuloendothelial System><CC Chemokine TARC><CCL17><CCL17 gene><CCL2><CCL2 gene><CCL5><CD 120a Antigen><CD120a Antigens><CD183><CD54 Antigens><CKR-L2><CMKAR3><CRG-2><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CXCL10><CXCL10 gene><CXCR3><CXCR3 gene><Cachectin><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Line><Cell Lineage><Cell Nucleus><Cell Signaling><CellLine><Cells><Chemokine (C-C Motif) Ligand 17><Chemokine (C-C Motif) Ligand 5><Chemokine (C-X-C Motif) Receptor 3><Chemokine, CC Motif, Ligand 2><Chronic><Circulation><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Common Cold><Culture Media><D17S136E><Data><Defect><Development><Disease><Disorder><Dose><FSGS><Focal and Segmental Glomerulosclerosis><Focal segmental glomerular sclerosis><G Protein-Coupled Receptor 9><GP130><GPR9><Genetic><Genomic DNA><Genomics><HPGF><Hepatocyte-Stimulating Factor><Heterograft><Heterologous Transplantation><Histologic><Histologically><Hodgkin Disease><Hodgkin Disorder><Hodgkin lymphoma><Hodgkin's><Hodgkin's Lymphoma><Hodgkin's disease><Hodgkins lymphoma><Human><Hybridoma Growth Factor><ICAM-1><IFI10><IFN-Gamma><IFN-beta 2><IFN-g><IFN-γ><IFNB2><IFNG><IFNγ><IL-13><IL-6><IL13><IL6 Protein><IL6ST><IL6ST gene><INP10><IP-10><IP10><IP10 Receptor><IP10-Mig receptor><IP10-R><Immune Interferon><Inbred BALB C Mice><Incidence><Individual><Injections><Injury><Integrins><Integrins Extracellular Matrix><Intercellular adhesion molecule 1><Interferon Gamma><Interferon Type II><Interleukin 6 Signal Transducer><Interleukin-13><Interleukin-6><Intracellular Communication and Signaling><Kidney><Kidney Urinary System><Lesion><Literature><LoxP-flanked allele><Lymphoma cell><Lymphotoxin><Lymphotoxin A><Lymphotoxin-alpha><Lymphotoxin-α><MCAF><MCP-1><MCP1><MGC17164><MGI-2><MOB-1><Macrophage-Derived TNF><Malignant><Malignant - descriptor><Malignant Lymphogranuloma><Member 1 TNF Superfamily><Mice><Mice Mammals><Mig Receptor><Mig-R><MigR><Modeling><Modern Man><Monocyte Chemoattractant Protein-1><Monocyte Chemotactic Protein-1><Monocyte Chemotactic and Activating Factor><Monocyte Chemotactic and Activating Protein><Monocyte Chemotactive and Activating Factor><Monocyte Secretory Protein JE><Monocyte-Derived TNF><Murine><Mus><Myeloid Differentiation-Inducing Protein><Nephrotic Syndrome><Nuclear><Nucleus><Patients><Plasmacytoma Growth Factor><Proteins><Publishing><RANTES><RNA Splicing><Receptor Protein><Recurrent disease><Reed-Sternberg Cells><Relapsed Disease><Rhinovirus><Rodent Model><SCYA17><SCYA2><SCYA5><SCYB10><SIS delta><SIS-delta><SISd><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Source><Splicing><Strains Cell Lines><T-Cell RANTES Protein><T-Cell Specific Protein p288><TARC><TCP228><TIMP-1><TNF><TNF A><TNF Alpha><TNF Receptor p55><TNF gene><TNF-b><TNF-beta><TNF-sR55><TNF-α><TNF-α receptor><TNF-β><TNFA><TNFAR><TNFR p60><TNFR, 55-kD><TNFR, 60-kD><TNFR-I><TNFR1><TNFR55><TNFR60><TNFRSF1A><TNFRSF1A Receptor><TNFRSF1A gene><TNFSF1><TNFalpha receptor><TNFα><TNFα receptor><TNFβ><Therapeutic><Tissue Inhibitor of Metalloproteinase-1><Tumor Cell><Tumor Necrosis Factor><Tumor Necrosis Factor Receptor 1><Tumor Necrosis Factor Receptor 55><Tumor Necrosis Factor-Beta><Tumor Necrosis Factor-alpha><Tumor Necrosis Factor-β><Visceral Epithelial Cell><Xenograft><Xenograft procedure><Xenotransplantation><atopic triad><atopy><biological signal transduction><cultured cell line><cytokine><cytokine release syndrome><cytokine storm><developmental><experiment><experimental research><experimental study><experiments><floxed><floxed allele><gDNA><gIP-10><glomerular visceral epithelial cell><gp130 Transducer Chain><growth media><hypoimmunity><immune deficiency><immunodeficiency><improved><injuries><interferon beta 2><kidney biopsy><lFN-Gamma><mouse model><murine model><neoplastic cell><podocyte><prevent><preventing><promoter><promotor><receptor><renal><renal biopsy><response to therapy><response to treatment><therapeutic response><therapy response><treatment response><treatment responsiveness><tumor><tumor necrosis factor alpha receptor><tumor necrosis factor receptor 1A><tumor necrosis factor α receptor><xeno-transplant><xeno-transplantation>

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Jochen Meyer

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 52/100

Likely hiring

Solid budget

Active award

$337,770

FY 2026

Project Title

RECIPROCAL FEEDBACK MECHANISMS OF GLIOBLASTOMA AND NEURONAL NETWORK HYPEREXCITABILITY

Grant Number:

5R01CA263628-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/14/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Glioblastoma (GBM) and tumor-related epilepsy (TRE) are intimately linked and devastating neurological disorders lacking effective therapies despite decades of promising pre-clinical and clinical research. TRE is reported in 40-60% of all GBM patients, often as the presenting symptom, and therefore ...

Research Terms

<2-photon><AMPA Receptors><Acceleration><Acute><Address><Affect><Antioncogene Protein p53><Area><Astrocytes><Astrocytus><Astroglia><Autoregulation><Behavior monitoring><Behavioral><Body Tissues><Brain><Brain Nervous System><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Calcium><Cas nuclease technology><Cell Body><Cell Death><Cell Growth in Number><Cell Locomotion><Cell Migration><Cell Movement><Cell Multiplication><Cell Proliferation><Cells><Cellular Migration><Cellular Motility><Cellular Proliferation><Cellular Tumor Antigen P53><Chronic><Clinical Research><Clinical Study><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Communication><Connector Neuron><Coupled><Coupling><Cystine><DREADDs><Death Rate><Deceleration><Disease><Disease Progression><Disorder><Distant><EEG><Electroencephalogram><Electroencephalography><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Epileptogenesis><Evolution><Feedback><Flooding><Floods><GPC3><GPC3 gene><Gene variant><Generalized Growth><Genes><Genetic><Genetic Models><Genetic study><Glia><Glial Cells><Glioblastoma><Glutamate Receptor><Glutamates><Glypican><Glypican 3><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Growth><Homeostasis><Hyperactivity><Image><Immunocompetent><Impairment><Inflammation><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intervention><Invaded><Kolliker's reticulum><L-Cystine><L-Glutamate><Link><Malignant><Malignant - descriptor><Measures><Mediating><Methods><Mice><Mice Mammals><Modeling><Monitor><Motility><Motion><Murine><Mus><N Methyl D aspartic Acid><N methyl D aspartate><N-Methyl-D-Aspartate Receptors><N-Methyl-D-aspartate><N-Methylaspartate><N-Methylaspartate Receptors><NF-1><NF-1 Protein><NF-1 encoded protein><NF1><NF1 GRP><NF1 Protein><NF1 gene><NF1-GAP-Related Protein><NMDA><NMDA Receptor-Ionophore Complex><NMDA Receptors><Nature><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Neoplasm><Neural Tumor><Neurocyte><Neuroepithelial, Perineurial, and Schwann Cell Neoplasm><Neurofibromatosis 1 Genes><Neurofibromatosis Type 1 Gene Product><Neurofibromatosis Type 1 Protein><Neurofibromin><Neurofibromin 1><Neuroglia><Neuroglial Cells><Neurologic><Neurologic Disorders><Neurological><Neurological Disorders><Neurons><Non-neuronal cell><Nonneuronal cell><Oncoprotein p53><P53><Pathway interactions><Patients><Pattern><Phase><Phosphoprotein P53><Phosphoprotein pp53><Photons><Physiological Homeostasis><Population><Process><Proliferating><Protein Secretion><Protein TP53><Publishing><QOL><Quality of life><Rat Homolog of OCI-5><Reporting><Resolution><Risk Reduction><Runaway><Seizure Disorder><Seizures><Signal Pathway><Source><Symptoms><Synapses><Synaptic><TP53><TP53 gene><TRP53><Techniques><Testing><Therapeutic><Time><Tissue Growth><Tissues><Tumor Cell><Tumor Cell Invasion><Tumor Invasion><Tumor Protein p53><Tumor Protein p53 Gene><Tumor Tissue><Variant><Variation><allelic variant><antiporter><astrocytic glia><awake><behavioral monitoring><cancer progression><cell motility><co-morbid><co-morbidity><comorbidity><curative intervention><curative therapeutic><curative therapy><curative treatments><density><designer receptors exclusively activated by designer drugs><effective intervention><effective therapy><effective treatment><epilepsia><epileptogenic><experience><experiment><experimental research><experimental study><experiments><gain of function><genetic variant><genomic variant><glioblastoma multiforme><glutamate signaling><glutamatergic><glutamatergic dendrodendritic synapses><glutamatergic signaling><human disease><imaging><imaging in vivo><imaging study><immune competent><improved><in vivo><in vivo imaging><indexing><insight><islet><mRNA Expression><model organism><mortality><mortality rate><necrocytosis><neoplasm progression><neoplastic cell><neoplastic progression><nerve cement><neural><neural control><neural network><neural regulation><neurofibromatosis type 1 gene><neurofibromatosis type 1 protein/gene><neurological disease><neuromodulation><neuromodulatory><neuronal><neuronal tumor><neuroregulation><nf 1 Genes><novel><ontogeny><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pathway><pre-clinical research><preclinical research><protein p53><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resolutions><risk-reducing><spatial and temporal><spatial temporal><spatiotemporal><spongioblastoma multiforme><synapse><synapse formation><synapse inhibition><synaptic inhibition><synaptogenesis><tumor><tumor growth><tumor progression><tumor xenograft><two-photon>

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ERIK M JORGENSEN

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 52/100

Likely hiring

Solid budget

Active award

$317,240

FY 2026

Project Title

Genome engineering in the nematode C. elegans

Grant Number:

5R01GM146005-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary CRISPR offers the promise of total control over genes in model organisms, such as the nematode C. elegans. To make this a reality, we need functional tags on all proteins that we can use as handles to influence the biology of any cell. However, each individual edit requires unique r...

Research Terms

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MATTHEW N RASBAND

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 52/100

Likely hiring

Solid budget

Active award

$306,000

FY 2026

Project Title

Mechanisms of sodium channel clustering at the neuromuscular junction

Grant Number:

5R01AR074988-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/20/2020

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Na+ channels are highly clustered at the neuromuscular junction (NMJ) deep in the junctional folds below acetylcholine receptors (AChRs) and in a sub-micron, highly specialized perijunctional zone (PJZ) surrounding the AChRs and synapse; intriguingly, dystrophin is also enriched in t...

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Peter B Lillehoj

RICE UNIVERSITY, HOUSTON, TX

Good lead · 48/100

Above-average budget

Very recent

Active award

$769,792

FY 2026

Project Title

CRISPR-Cas13-based rapid HIV-1 test

Grant Number:

4R33AI167037-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/24/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

HIV is one of the most deadly infectious diseases in the world. HIV transmission is largely driven by acutely infected individuals who are unaware of their status or those receiving antiretroviral therapy but not virally suppressed. Currently available rapid HIV tests, including fourth-generation HI...

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Laura Marie Prolo

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$209,177

FY 2026

Project Title

Targeting the MAP4K4 pathway to inhibit pediatric high-grade glioma invasion

Grant Number:

1K08NS140556-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Hemispheric high-grade gliomas (HGGs) in children are fast-growing and become rapidly widespread; the median survival rates for these diagnoses are measured in months, not years. It is therefore critical to discover more about the pathophysiology of pediatric HGGs (pHGGs), particular...

Research Terms

<0-11 years old><Abscission><Acceleration><Animal Model><Animal Models and Related Studies><Apoptosis><Apoptosis Pathway><Assay><Behavior><Bioassay><Biochemical><Biological Assay><Body Tissues><Brain><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><CNS Nervous System><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancers><Cas nuclease technology><Cell Body><Cell Function><Cell Line><Cell Physiology><Cell Process><Cell-Extracellular Matrix><CellLine><Cells><Cellular Function><Cellular Physiology><Cellular Process><Central Nervous System><Characteristics><Chemistry><Child><Child Youth><Childhood><Childhood Brain Neoplasm><Childhood Brain Tumor><Childhood Glioma><Children (0-21)><Children's Hospital><Classification><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Colorectal Cancer><Communities><Cultured Neoplastic Cells><Cultured Tumor Cells><DNA Alteration><DNA Sequence Alteration><Data><Data Bases><Databases><Development><Diagnosis><Dissection><Doctor of Philosophy><Drug Design><Drug Targeting><Drugs><Dysfunction><ECM><Effectiveness><Encephalon><Excision><Extirpation><Extracellular Matrix><Functional disorder><Future><Generalized Growth><Genes><Genetic><Genetic Alteration><Genomics><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioblastoma><Glioma><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Growth><Hepatocarcinoma><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Heterograft><Heterologous Transplantation><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><IVIS SpectrumCT><IVIS imaging><IVIS optical imaging><IVIS spectral imaging><IVIS spectrum><IVIS system><Image><Imaging Device><Imaging Instrument><Imaging Tool><In Vitro><Infiltration><Invaded><JNKK1 Protein Kinase><Kinases><Laboratories><Liver Cells Carcinoma><Luciferase Immunologic><Luciferases><MAP Kinase 4><MAP Kinase Isoform P63><MAP Kinase Kinase 4><MAP2K4 gene><MEK4 Protein Kinase><Malignant Glial Neoplasm><Malignant Glial Tumor><Malignant Glioma><Malignant Neoplasms><Malignant Neuroglial Neoplasm><Malignant Neuroglial Tumor><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Malignant neoplasm of pancreas><Malignant neoplasm of prostate><Malignant prostatic tumor><Measures><Medication><Medulloblastoma><Methods><Methylation><Mice><Mice Mammals><Mitogen-Activated Protein Kinase Kinase 4><Molecular><Molecular Probes><Murine><Mus><Nature><Neuraxis><Neuroglial Neoplasm><Neuroglial Tumor><Normal Cell><Operative Procedures><Operative Surgical Procedures><Outcome><Pancreas Cancer><Pancreatic Cancer><Paraffin Embedding><Pathway interactions><Patients><Pediatric Glioma><Pediatric Hospitals><Pediatric high-grade glioma><Peripheral><Ph.D.><PhD><Pharmaceutical Preparations><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiological><Physiopathology><Play><Primary Neoplasm><Primary Tumor><Primary carcinoma of the liver cells><Prognosis><Prognostic Marker><Programmed Cell Death><Proliferating><Prostate CA><Prostate Cancer><Prostate malignancy><Publishing><Pulmonary Cancer><Pulmonary malignant Neoplasm><Randomized><Recurrent Neoplasm><Recurrent tumor><Regulation><Removal><Reporter Genes><Research><Research Specimen><Role><SAP Kinase Kinase 1><SAP Kinase-Extracellular Signal-Regulated Kinase Kinase 1><SAPK-ERK Kinase 1><SEK1 Protein Kinase><Scientist><Sequence Alteration><Specificity><Specimen><Speed><Strains Cell Lines><Stress-Activated Protein Kinase Kinase 1><Stromal Cells><Subcellular Process><Subgroup><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Survival Rate><Systematics><Techniques><Testing><Therapeutic><Time><Tissue Growth><Tissues><Translational Research><Translational Science><Transphosphorylases><Tumor Cell><Tumor Cell Invasion><Tumor Cell Line><Tumor Invasion><Variant><Variation><Visualization><Xenograft><Xenograft procedure><Xenotransplantation><brain parenchyma><cancer imaging><cancer microenvironment><cancer type><chemotherapy><clinical prognosis><cohort><cultured cell line><data base><developmental><drug/agent><druggable target><epigenomics><expression subtypes><extracellular signal-regulated kinase 4><genomic alteration><glial-derived tumor><glioblastoma multiforme><imaging><improved><in vivo><in vivo imaging system><inhibitor><innovate><innovation><innovative><intervention design><kids><liver carcinoma><lung cancer><malignancy><methylomics><mitogen-activated protein kinase 4><model of animal><molecular phenotype><molecular sub-types><molecular subsets><molecular subtypes><mouse model><murine model><neoplasm recurrence><neoplasm/cancer><neoplastic cell><neuro-oncology><neuroglia neoplasm><neuroglia tumor><neurooncology><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oncologic imaging><oncology imaging><ontogeny><pancreatic malignancy><pathophysiology><pathway><pediatric><pediatric brain neoplasm><pediatric brain tumor><pharmacologic><prevent><preventing><prognostic biomarker><prognostic indicator><randomisation><randomization><randomly assigned><rat Erk3-related mitogen activated kinase><rat Mapk4 protein><rat extracellular signal-regulated kinase 4><rat mitogen-activated protein kinase 4><rat p63MAPK protein><resection><social role><spheroids><spongioblastoma multiforme><surgery><therapeutic evaluation><therapeutic testing><therapy design><tool><translation research><translational investigation><treatment design><treatment strategy><tumor><tumor imaging><tumor microenvironment><tumors in the brain><xeno-transplant><xeno-transplantation><youngster>

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Jonathan Douglas Rumley

COLUMBIA UNIV NEW YORK MORNINGSIDE, NEW YORK, NY

Good lead · 48/100

Training-friendly

Very recent

Active award

$85,224

FY 2026

Project Title

Dissecting regulation and function of unc-6/Netrin via the generation of cis-regulatory alleles

Grant Number:

5F32MH136667-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/7/2024

End Date:

2/28/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The “Netrin system” has well-studied roles in axon pathfinding and less studied roles in synapse formation in animals from worms to humans. I propose to study the relative contribution of UNC- 6/Netrin derived from multiple neuronal and non-neuronal sources by characterizing the expr...

Research Terms

<21+ years old><Abscission><Adult><Adult Human><Alleles><Allelomorphs><Animal Model><Animal Models and Related Studies><Animals><Axon><Basal Transcription Factor><Basal transcription factor genes><Binding Sites><Biologic Models><Biological Models><C elegans><C. elegans><C.elegans><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Caenorhabditis elegans><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Collection><Color><Combining Site><Communication><Cues><Embryo><Embryonic><Environment><Event><Excision><Extirpation><Functional RNA><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genome engineering><Glia><Glial Cells><Goals><Hermaphroditism><Human><Individual><Institution><Intersexuality><Intervening Sequences><Intracellular Communication and Signaling><Introns><Investigators><Kolliker's reticulum><Label><Ligands><Link><Location><Logic><Maintenance><Mediating><Mentorship><Model System><Modern Man><Nematoda><Nematodes><Nerve><Nerve Cells><Nerve Unit><Neural Cell><Neurites><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurological Development Disorder><Neurons><Neurosciences><Non-neuronal cell><Noncoding RNA><Nonneuronal cell><Nontranslated RNA><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Pattern><Phenotype><Play><Reactive Site><Reagent><Receptor Protein><Regulation><Regulatory Element><Regulatory Regions><Removal><Reporter><Reporting><Research><Research Personnel><Researchers><Review Literature><Role><Signal Transduction><Signal Transduction Systems><Signaling><Source><Surgical Removal><Synapses><Synaptic><System><Testing><Training><Transcription Factor Proto-Oncogene><Transcription Initiation Site><Transcription Start Site><Transcription factor genes><Transgenes><Universities><Untranslated RNA><Upstream Stimulatory Factor><Upstream Transcription Factor><Vertebrate Animals><Vertebrates><Visualization><Work><Writing><adulthood><axon growth cone guidance><axon guidance><axonal pathfinding><biological signal transduction><cell type><experiment><experimental research><experimental study><experiments><genetic regulatory element><helix-loop-helix activator USF><improved><model of animal><mutant><nerve cement><neurodevelopmental disease><neurogenetics><neuronal><neuronal circuit><neuronal circuitry><new approaches><noncoding><novel approaches><novel strategies><novel strategy><oral communication><post-doctoral training><receptor><resection><roundworm><scRNA sequencing><scRNA-seq><selective expression><selectively expressed><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><synapse><synapse formation><synaptogenesis><transcription factor><transcription factor MLTF><transcription factor USF><transgene><vertebrata>

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Daniel Andrés Colon-Rios

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 48/100

Training-friendly

Very recent

Active award

$55,114

FY 2026

Project Title

Elucidating mechanisms of PARP inhibitor resistance in IDH-mutant cancers

Grant Number:

5F30CA291077-02

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Isocitrate dehydrogenase (IDH) mutations are found in many malignancies including gliomas, cholangiocarcinomas, and acute myeloid leukemia. Mutations in the IDH gene lead to the neomorphic production of 2-hydroxyglurate (2HG), a competitive inhibitor of -ketoglutarate. A series of clinical studies ...

Research Terms

<53BP1><AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Assay><BRCA1><BRCA1 Gene Product><BRCA1 Protein><BRCA1 gene><BRCA2><BRCA2 gene><Bioassay><Biological Assay><Breast Cancer><Breast Cancer 1 Gene><Breast Cancer 1 Gene Product><Breast Cancer 2 Gene><Breast Cancer Type 1 Susceptibility Gene><Breast Cancer Type 1 Susceptibility Protein><Breast Cancer Type 2 Susceptibility Gene><Breast-Ovarian Cancer Protein><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Drug><Cancer Treatment><Cancers><Cas nuclease technology><Cell Body><Cell Line><Cell Survival><Cell Viability><CellLine><Cells><ChIP assay><Chemotherapy and Radiation><Chemotherapy and/or radiation><Cholangiocarcinoma><Cholangiocellular Carcinoma><Chromatin><Chromatin Structure><Citric Acid Cycle><Clinical Research><Clinical Study><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Comet Assay><Complement><Complement Proteins><DNA Damage><DNA Damage Repair><DNA Double Strand Break><DNA Injury><DNA Repair><DNA mutation><DNA replication fork><Data><Defect><Dioxygenases><Down-Regulation><Drug resistance><Early Onset Gene Breast Cancer 1><Early Onset Gene Breast Cancer 2><Early Onset Protein Breast Cancer 1><Enzyme Gene><Enzymes><Exhibits><FANCD1><Foundations><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioma><Hereditary Breast Cancer 1><Hereditary Breast Cancer 2><Heterogeneity><Human><Human Genome><Immunofluorescence><Immunofluorescence Immunologic><Impairment><Individual><Isocitrate Dehydrogenase><Isoforms><Knock-out><Knockout><Krebs Cycle><Lead><Libraries><Link><Malignant Breast Neoplasm><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Ovarian Neoplasm><Malignant Ovarian Tumor><Malignant Tumor><Malignant Tumor of the Ovary><Malignant neoplasm of ovary><Mediating><Methodology><Methods><Methylation><Modeling><Modern Man><Mutation><NGS Method><NGS system><Neoplastic Disease Chemotherapeutic Agents><Neuroglial Neoplasm><Neuroglial Tumor><Output><Ovary Cancer><PARP Inhibitor><PARP Polymerase><PARP protein><PARP-1 inhibitor><PARPi><PARS><Parents><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Physical condensation><Physicians><Poly(ADP-ribose) Polymerase Inhibitor><Poly(ADP-ribose) Polymerases><Poly(ADP-ribose) polymerase 1 inhibitor><Poly(ADPribose) Polymerase><Production><Protein Isoforms><Proteins><RNA Seq><RNA analysis><RNA sequencing><RNAseq><RNF53><Radiation therapy><Radiotherapeutics><Radiotherapy><Regulation><Research><Resistance><Scientist><Series><Single-Cell Gel Electrophoresis><Site><Strains Cell Lines><TCA cycle><TP53BP1><Techniques><Testing><Therapeutic><Training><Tricarboxylic Acid Cycle><Tumor-Specific Treatment Agents><Unscheduled DNA Synthesis><Visualization><Work><acute granulocytic leukemia><acute myeloid leukemia><anti-cancer drug><anti-cancer therapy><biliary cancer><brca 1 gene><brca 2 gene><cancer cell><cancer therapy><cancer-directed therapy><chemo/radiation therapy><chemotherapy and radiotherapy><cholangiosarcoma><chromatin immunoprecipitation><chromatin remodeling><combinatorial><complementation><condensation><cultured cell line><drug resistant><exome sequencing><exome-seq><genome mutation><genome scale><genome-wide><genomewide><glial-derived tumor><graduate student><heavy metal Pb><heavy metal lead><human whole genome><inhibitor><insight><interest><malignancy><malignant breast tumor><mutant><neoplasm/cancer><neuroglia neoplasm><neuroglia tumor><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next gen sequencing><next generation sequencing><next generation therapeutics><nextgen sequencing><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ovarian cancer><p202><p53-binding protein 1><p53BP1><parent><pathway><patient oriented outcomes><poly ADP polymerase><poly ADP ribose synthetase><pre-clinical study><preclinical study><radiation or chemotherapy><radiation treatment><recruit><repair><repaired><replication fork><resistance mechanism><resistance to Drug><resistant><resistant mechanism><resistant to Drug><response><restoration><synergism><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcriptome sequencing><transcriptomic sequencing><transcriptomics><treatment with radiation><tumor><tumor xenograft>

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Saeed F Tavazoie

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 42/100

Likely hiring

Active award

$195,845

FY 2026

Project Title

Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival

Grant Number:

5R01CA257153-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/12/2021

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Summary Our preliminary results support a prominent role for dysregulation of RNA binding proteins (RBPs) in cancer progression. In fact, our analysis of the cancer genome atlas (TCGA) transcriptome data shows that RBPs, as a group, are significantly more dysregulated in cancer than transcription fa...

Research Terms

<3' Untranslated Regions><3'UTR><5' Untranslated Regions><5'UTR><Algorithms><Area><Basal Transcription Factor><Basal transcription factor genes><Binding><Binding Proteins><Binding Sites><Biochemical><Biological><Biology><Breast Metastasis><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><Cancers><Cell Body><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cells><Cellular Proliferation><Clinical><Clinical Oncology><Clinical stratification><Clustered Regularly Interspaced Short Palindromic Repeats><Collaborations><Combining Site><Computer Analysis><Data><Diagnosis><Diagnostic><Differential Gene Expression><Elements><Epistasis><Epistatic Deviation><Exhibits><Functional RNA><Gene Proteins><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Epistasis><Genetic Screening><Goals><History><Human Genome><In Vitro><Individual><Interaction Deviation><Knowledge><Laboratories><Ligand Binding Protein><Ligand Binding Protein Gene><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Maps><Mediating><Messenger RNA><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Mice><Mice Mammals><MicroRNAs><Molecular><Molecular Interaction><Murine><Mus><Neoplasm Metastasis><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Oncogenesis><Orphan><Pathway interactions><Patients><Phenotype><Play><Position><Positioning Attribute><Precision therapeutics><Primary Neoplasm><Primary Tumor><Process><Protein Binding><Protein Gene Products><RNA><RNA Gene Products><RNA Sequences><RNA-Binding Proteins><Reactive Site><Recording of previous events><Regulatory Element><Regulatory Pathway><Regulatory Protein><Regulon><Research><Ribonucleic Acid><Role><Sampling><Secondary Neoplasm><Secondary Tumor><Stratification><TCGA><Technology><The Cancer Genome Atlas><Therapeutic Intervention><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Transcript><Transcription Factor Proto-Oncogene><Transcription factor genes><Universities><Untranslated RNA><Work><Xenograft Model><biologic><bound protein><breast cancer metastasis><cancer cell><cancer metastasis><cancer progression><cancer type><clinical prognostic><clinical relevance><clinical significance><clinically relevant><clinically significant><clustered regularly interspaced short palindromic repeats screen><cohort><computational analyses><computational analysis><computational framework><computational studies><computer analyses><computer framework><computer studies><epistatic interaction><epistatic relationship><experiment><experimental research><experimental study><experiments><gene x gene interaction><genetic epistases><genetic regulatory protein><global gene expression><global transcription profile><histories><human whole genome><in vivo><intervention therapy><knock-down><knockdown><large data sets><large datasets><loss of function><mRNA><mRNA Expression><mRNA Leader Sequences><mRNA Stability><malignancy><miRNA><neoplasm progression><neoplasm/cancer><neoplastic progression><noncoding><novel><pathway><patient stratification><posttranscriptional><precision therapies><precision treatment><prognostic><regulatory gene product><shRNA><short hairpin RNA><social role><stratified patient><transcription factor><transcriptome><tumor><tumor cell metastasis><tumor growth><tumor progression><tumorigenesis><xenograft transplant model><xenotransplant model>

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Sohail F. Tavazoie

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 42/100

Likely hiring

Active award

$195,845

FY 2026

Project Title

Mapping the regulatory landscape of RNA binding proteins and their causal roles in tumorigenesis and patient survival

Grant Number:

5R01CA257153-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/12/2021

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Summary Our preliminary results support a prominent role for dysregulation of RNA binding proteins (RBPs) in cancer progression. In fact, our analysis of the cancer genome atlas (TCGA) transcriptome data shows that RBPs, as a group, are significantly more dysregulated in cancer than transcription fa...

Research Terms

<3' Untranslated Regions><3'UTR><5' Untranslated Regions><5'UTR><Algorithms><Area><Basal Transcription Factor><Basal transcription factor genes><Binding><Binding Proteins><Binding Sites><Biochemical><Biological><Biology><Breast Metastasis><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><Cancers><Cell Body><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cells><Cellular Proliferation><Clinical><Clinical Oncology><Clinical stratification><Clustered Regularly Interspaced Short Palindromic Repeats><Collaborations><Combining Site><Computer Analysis><Data><Diagnosis><Diagnostic><Differential Gene Expression><Elements><Epistasis><Epistatic Deviation><Exhibits><Functional RNA><Gene Proteins><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Epistasis><Genetic Screening><Goals><History><Human Genome><In Vitro><Individual><Interaction Deviation><Knowledge><Laboratories><Ligand Binding Protein><Ligand Binding Protein Gene><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Maps><Mediating><Messenger RNA><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Mice><Mice Mammals><MicroRNAs><Molecular><Molecular Interaction><Murine><Mus><Neoplasm Metastasis><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Oncogenesis><Orphan><Pathway interactions><Patients><Phenotype><Play><Position><Positioning Attribute><Precision therapeutics><Primary Neoplasm><Primary Tumor><Process><Protein Binding><Protein Gene Products><RNA><RNA Gene Products><RNA Sequences><RNA-Binding Proteins><Reactive Site><Recording of previous events><Regulatory Element><Regulatory Pathway><Regulatory Protein><Regulon><Research><Ribonucleic Acid><Role><Sampling><Secondary Neoplasm><Secondary Tumor><Stratification><TCGA><Technology><The Cancer Genome Atlas><Therapeutic Intervention><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Transcript><Transcription Factor Proto-Oncogene><Transcription factor genes><Universities><Untranslated RNA><Work><Xenograft Model><biologic><bound protein><breast cancer metastasis><cancer cell><cancer metastasis><cancer progression><cancer type><clinical prognostic><clinical relevance><clinical significance><clinically relevant><clinically significant><clustered regularly interspaced short palindromic repeats screen><cohort><computational analyses><computational analysis><computational framework><computational studies><computer analyses><computer framework><computer studies><epistatic interaction><epistatic relationship><experiment><experimental research><experimental study><experiments><gene x gene interaction><genetic epistases><genetic regulatory protein><global gene expression><global transcription profile><histories><human whole genome><in vivo><intervention therapy><knock-down><knockdown><large data sets><large datasets><loss of function><mRNA><mRNA Expression><mRNA Leader Sequences><mRNA Stability><malignancy><miRNA><neoplasm progression><neoplasm/cancer><neoplastic progression><noncoding><novel><pathway><patient stratification><posttranscriptional><precision therapies><precision treatment><prognostic><regulatory gene product><shRNA><short hairpin RNA><social role><stratified patient><transcription factor><transcriptome><tumor><tumor cell metastasis><tumor growth><tumor progression><tumorigenesis><xenograft transplant model><xenotransplant model>

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Ryan William Nelson

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$194,935

FY 2026

Project Title

Lung resident Treg suppression of Th2 resident memory T cells in allergicasthma

Grant Number:

5K08AI171176-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/4/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Defining how FoxP3+ regulatory T cells (Tregs) limit amnestic responses to common allergens has the potential to provide new and effective therapies for asthma and other atopic diseases. Recent work has demonstrated that T helper type 2 (Th2) tissue-resident memory T cells (Trm) pers...

Research Terms

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Rebecca A Butcher

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 42/100

Likely hiring

Active award

$68,960

FY 2026

Project Title

Small-molecule signals controlling nematode development

Grant Number:

3R35GM144076-05S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2021

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract The nematode Caenorhabditis elegans relies on small-molecule signals to control its development, metabolism, physiology, and behavior, and these signals play conserved roles in many parasitic nematode species. This MIRA application outlines our ongoing efforts to understand ...

Research Terms

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CHRISTOPHER D VULPE

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 42/100

Likely hiring

Active award

$25,917

FY 2026

Project Title

CRISPR screens of population relevant genes governing toxicant resilience

Grant Number:

3R01ES033625-05S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2022

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

People vary considerably in their response to and in the effects of exposure to chemical toxicants and biological toxins. As a result, the risk of adverse outcomes associated with exposure for different individuals and populations can be widely divergent. Gene by environment (G x E) interactions lik...

Research Terms

<3-D><3-Dimensional><3D><Adverse effects><Affect><Biological><CRISPR><CRISPR editing screen><CRISPR library><CRISPR screen><CRISPR-based library><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 library><CRISPR/Cas9 screen><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Growth in Number><Cell Line><Cell Multiplication><Cell Proliferation><Cell model><CellLine><Cells><Cellular Proliferation><Cellular model><Chemicals><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats library><Complex><Coupled><DNA mutation><Data Bases><Databases><Dose><Environment><Environmental Exposure><Evaluation><Exposure to><Frequencies><Gene Expression><Gene Transcription><Gene variant><Gene x Environment Interaction><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic Transcription><Genetic Variation><Genetic defect><Genetic mutation><Genetic propensity><GxE interaction><Health><Human><Human Genetics><Individual><Inherited Predisposition><Inherited Susceptibility><Libraries><Measures><Metabolic><Modern Man><Mutation><Organoids><Outcome><Pathway interactions><Persons><Phenotype><Physiologic><Physiological><Population><Predisposition><Preventive><Public Health><RNA Expression><Reporter><Research Resources><Resources><Risk><Risk Assessment><Role><Strains Cell Lines><Stress><Susceptibility><Therapeutic><Toxicant exposure><Toxicogenomics><Toxicology><Toxin><Transcription><Validation><Variant><Variation><adverse consequence><adverse outcome><allelic variant><biologic><biological adaptation to stress><candidate identification><cellular differentiation><clustered regularly interspaced short palindromic repeats screen><comparative><cultured cell line><data base><drug candidate><environment effect on gene><environmental stresses><environmental stressor><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><gene environment interaction><genetic association><genetic variant><genetic vulnerability><genetically predisposed><genome mutation><genomic variant><improved><loss of function><loss of function mutation><pathway><reactioncrisis><resilience><resilient><response><risk mitigation><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stress response><stressreaction><stressor><success><three dimensional><tool><toxic exposure><toxicant><validations><vector>

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VIVEK KUMAR

PENNSYLVANIA STATE UNIV HERSHEY MED CTR, HERSHEY, PA

Exploratory lead · 40/100

Large award

Active award

$3,835,481

FY 2026

Project Title

Cross Scale Interrogation of NPD Genes (SING) in mice

Grant Number:

5RM1MH138309-02

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2025

End Date:

11/30/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Neurodevelopmental and psychiatric disorders (NPDs) are highly prevalent and devasting neurological conditions without cure. Recent genetic studies on NPDs identified hundreds of high-risk NPD-related genes, yet it remains unclear how these genes individually or collectively affect neurodev...

Research Terms

<2 year old><2 years of age><3-D><3-Dimensional><3D><Acceleration><Affect><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Antibodies><Architecture><Assay><Atlases><Behavior><Behavioral><Bioassay><Biological><Biological Assay><Biology><Body Tissues><Brachydanio rerio><Brain><Brain Nervous System><Brain Vascular><Breeding><Bypass><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cells><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cognitive><Communities><Complex><Consumption><DNA mutation><Danio rerio><Data><Data Analyses><Data Analysis><Data Set><Development><Disease><Disorder><Disparate><Dysfunction><Eating><Encephalon><Engineering / Architecture><Essential Genes><Ethology><Food Intake><Functional disorder><Funding><Future><Gene Deletion><Gene Expression><Generations><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetic study><Genomics><Glia><Glial Cells><Home><Human Genetics><In Situ><Individual><Injections><Internet><Intervention><Investigators><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Kolliker's reticulum><Label><Laboratory mice><MR Imaging><MR Tomography><MRI><MRIs><Machine Learning><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental disorders><Mental health disorders><Methodology><Methods><Mice><Mice Mammals><Molecular><Monitor><Murine><Mus><Mutation><NMR Imaging><NMR Tomography><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurologic><Neurologic Body System><Neurologic Organ System><Neurological><Neurological Development Disorder><Neurons><Neurosciences><Non-Polyadenylated RNA><Non-neuronal cell><Nonneuronal cell><Nuclear Magnetic Resonance Imaging><Null Mouse><Organoids><Output><Pathologic><Pathway interactions><Pattern><Physiopathology><Pilot Projects><Prefrontal Cortex><Process><Psychiatric Disease><Psychiatric Disorder><RNA><RNA Gene Products><Research Personnel><Research Resources><Researchers><Resolution><Resources><Ribonucleic Acid><Risk-associated variant><Shapes><Sleep><Structure><System><The Jackson Laboratory><Therapeutic><Therapeutic Intervention><Time><Tissues><Viral><Visualization><WWW><Work><Zebra Danio><Zebra Fish><Zebrafish><Zeugmatography><age 2><age 2 years><aged 2 years><aged two years><big imaging data><biologic><brain based><brain volume><cell type><cerebral vascular><cerebro-vascular><cerebrovascular><data integration><data interpretation><data sharing><developmental><drinking><endophenotype><experience><gene deletion mutation><gene function><genome mutation><global gene expression><global transcription profile><high risk><homes><innovate><innovation><innovative><insight><intervention therapy><knock out mouse project><large imaging data><large-scale imaging data><loss of function><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><mental illness><model of animal><mouse genetics><multi-modal data><multi-modal datasets><multi-modality><multi-scale data><multimodal data><multimodal datasets><multimodality><multiscale data><neonatal brain><nerve cement><neural circuit><neural circuitry><neurocircuitry><neurodevelopment effect><neurodevelopmental disease><neurodevelopmental effect><neuronal><novel><pathophysiology><pathway><pilot study><psychiatric illness><psychological disorder><resolutions><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social><synaptic circuit><synaptic circuitry><three dimensional><transcriptome><transcriptomics><two year old><two years of age><web><world wide web>

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Yongsoo Kim

PENNSYLVANIA STATE UNIV HERSHEY MED CTR, HERSHEY, PA

Exploratory lead · 40/100

Large award

Active award

$3,835,481

FY 2026

Project Title

Cross Scale Interrogation of NPD Genes (SING) in mice

Grant Number:

5RM1MH138309-02

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2025

End Date:

11/30/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Neurodevelopmental and psychiatric disorders (NPDs) are highly prevalent and devasting neurological conditions without cure. Recent genetic studies on NPDs identified hundreds of high-risk NPD-related genes, yet it remains unclear how these genes individually or collectively affect neurodev...

Research Terms

<2 year old><2 years of age><3-D><3-Dimensional><3D><Acceleration><Affect><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Antibodies><Architecture><Assay><Atlases><Behavior><Behavioral><Bioassay><Biological><Biological Assay><Biology><Body Tissues><Brachydanio rerio><Brain><Brain Nervous System><Brain Vascular><Breeding><Bypass><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cells><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cognitive><Communities><Complex><Consumption><DNA mutation><Danio rerio><Data><Data Analyses><Data Analysis><Data Set><Development><Disease><Disorder><Disparate><Dysfunction><Eating><Encephalon><Engineering / Architecture><Essential Genes><Ethology><Food Intake><Functional disorder><Funding><Future><Gene Deletion><Gene Expression><Generations><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetic study><Genomics><Glia><Glial Cells><Home><Human Genetics><In Situ><Individual><Injections><Internet><Intervention><Investigators><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Kolliker's reticulum><Label><Laboratory mice><MR Imaging><MR Tomography><MRI><MRIs><Machine Learning><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental disorders><Mental health disorders><Methodology><Methods><Mice><Mice Mammals><Molecular><Monitor><Murine><Mus><Mutation><NMR Imaging><NMR Tomography><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurologic><Neurologic Body System><Neurologic Organ System><Neurological><Neurological Development Disorder><Neurons><Neurosciences><Non-Polyadenylated RNA><Non-neuronal cell><Nonneuronal cell><Nuclear Magnetic Resonance Imaging><Null Mouse><Organoids><Output><Pathologic><Pathway interactions><Pattern><Physiopathology><Pilot Projects><Prefrontal Cortex><Process><Psychiatric Disease><Psychiatric Disorder><RNA><RNA Gene Products><Research Personnel><Research Resources><Researchers><Resolution><Resources><Ribonucleic Acid><Risk-associated variant><Shapes><Sleep><Structure><System><The Jackson Laboratory><Therapeutic><Therapeutic Intervention><Time><Tissues><Viral><Visualization><WWW><Work><Zebra Danio><Zebra Fish><Zebrafish><Zeugmatography><age 2><age 2 years><aged 2 years><aged two years><big imaging data><biologic><brain based><brain volume><cell type><cerebral vascular><cerebro-vascular><cerebrovascular><data integration><data interpretation><data sharing><developmental><drinking><endophenotype><experience><gene deletion mutation><gene function><genome mutation><global gene expression><global transcription profile><high risk><homes><innovate><innovation><innovative><insight><intervention therapy><knock out mouse project><large imaging data><large-scale imaging data><loss of function><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><mental illness><model of animal><mouse genetics><multi-modal data><multi-modal datasets><multi-modality><multi-scale data><multimodal data><multimodal datasets><multimodality><multiscale data><neonatal brain><nerve cement><neural circuit><neural circuitry><neurocircuitry><neurodevelopment effect><neurodevelopmental disease><neurodevelopmental effect><neuronal><novel><pathophysiology><pathway><pilot study><psychiatric illness><psychological disorder><resolutions><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social><synaptic circuit><synaptic circuitry><three dimensional><transcriptome><transcriptomics><two year old><two years of age><web><world wide web>

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ANIRBAN PAUL

PENNSYLVANIA STATE UNIV HERSHEY MED CTR, HERSHEY, PA

Exploratory lead · 40/100

Large award

Active award

$3,835,481

FY 2026

Project Title

Cross Scale Interrogation of NPD Genes (SING) in mice

Grant Number:

5RM1MH138309-02

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2025

End Date:

11/30/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Neurodevelopmental and psychiatric disorders (NPDs) are highly prevalent and devasting neurological conditions without cure. Recent genetic studies on NPDs identified hundreds of high-risk NPD-related genes, yet it remains unclear how these genes individually or collectively affect neurodev...

Research Terms

<2 year old><2 years of age><3-D><3-Dimensional><3D><Acceleration><Affect><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Antibodies><Architecture><Assay><Atlases><Behavior><Behavioral><Bioassay><Biological><Biological Assay><Biology><Body Tissues><Brachydanio rerio><Brain><Brain Nervous System><Brain Vascular><Breeding><Bypass><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cells><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cognitive><Communities><Complex><Consumption><DNA mutation><Danio rerio><Data><Data Analyses><Data Analysis><Data Set><Development><Disease><Disorder><Disparate><Dysfunction><Eating><Encephalon><Engineering / Architecture><Essential Genes><Ethology><Food Intake><Functional disorder><Funding><Future><Gene Deletion><Gene Expression><Generations><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetic study><Genomics><Glia><Glial Cells><Home><Human Genetics><In Situ><Individual><Injections><Internet><Intervention><Investigators><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Kolliker's reticulum><Label><Laboratory mice><MR Imaging><MR Tomography><MRI><MRIs><Machine Learning><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental disorders><Mental health disorders><Methodology><Methods><Mice><Mice Mammals><Molecular><Monitor><Murine><Mus><Mutation><NMR Imaging><NMR Tomography><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurologic><Neurologic Body System><Neurologic Organ System><Neurological><Neurological Development Disorder><Neurons><Neurosciences><Non-Polyadenylated RNA><Non-neuronal cell><Nonneuronal cell><Nuclear Magnetic Resonance Imaging><Null Mouse><Organoids><Output><Pathologic><Pathway interactions><Pattern><Physiopathology><Pilot Projects><Prefrontal Cortex><Process><Psychiatric Disease><Psychiatric Disorder><RNA><RNA Gene Products><Research Personnel><Research Resources><Researchers><Resolution><Resources><Ribonucleic Acid><Risk-associated variant><Shapes><Sleep><Structure><System><The Jackson Laboratory><Therapeutic><Therapeutic Intervention><Time><Tissues><Viral><Visualization><WWW><Work><Zebra Danio><Zebra Fish><Zebrafish><Zeugmatography><age 2><age 2 years><aged 2 years><aged two years><big imaging data><biologic><brain based><brain volume><cell type><cerebral vascular><cerebro-vascular><cerebrovascular><data integration><data interpretation><data sharing><developmental><drinking><endophenotype><experience><gene deletion mutation><gene function><genome mutation><global gene expression><global transcription profile><high risk><homes><innovate><innovation><innovative><insight><intervention therapy><knock out mouse project><large imaging data><large-scale imaging data><loss of function><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><mental illness><model of animal><mouse genetics><multi-modal data><multi-modal datasets><multi-modality><multi-scale data><multimodal data><multimodal datasets><multimodality><multiscale data><neonatal brain><nerve cement><neural circuit><neural circuitry><neurocircuitry><neurodevelopment effect><neurodevelopmental disease><neurodevelopmental effect><neuronal><novel><pathophysiology><pathway><pilot study><psychiatric illness><psychological disorder><resolutions><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social><synaptic circuit><synaptic circuitry><three dimensional><transcriptome><transcriptomics><two year old><two years of age><web><world wide web>

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Prem P Chapagain

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Exploratory lead · 40/100

Large award

Active award

$1,319,674

FY 2026

Project Title

CRISPR/dCas9-Targeted Histone Demethylation Interplays with DNA Repair to Contract GAA Repeats in Friedreich's Ataxia

Grant Number:

1RM1NS143850-01

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/26/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

Friedreich’s ataxia (FRDA) is the most common autosomal recessive ataxia. It is caused by expanded GAA repeats at the first intron of the frataxin (FXN) gene. No effective treatments are available for the disease due to the inherited expanded GAA repeats in the patient’s genome. Thus, there is an ur...

Research Terms

<3-D><3-Dimensional><3D><AI Augmented><AI assisted><AI driven><AI enhanced><AI integrated><AI powered><AI system><Affect><Architecture><Artificial Intelligence><Artificial Intelligence enhanced><Ataxia><Ataxy><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><BBB function><Base Excision Repairs><Basic Research><Basic Science><Binding Proteins><Biochemistry><Biological Chemistry><Blood - brain barrier anatomy><Blood-Brain Barrier><Brain><Brain Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiac><Cas nuclease technology><Cell Body><Cell Communication><Cell Differentiation><Cell Differentiation process><Cell Interaction><Cell-to-Cell Interaction><Cells><Cerebrum><Chemistry><Chromatin><Clinical Research><Clinical Study><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Computer Reasoning><Contracting Opportunities><Contracts><Coordination Impairment><Country><DNA Base Excision Repair><DNA Damage Repair><DNA Repair><DNA Therapy><Dimensions><Disease><Disorder><Dyssynergia><Encapsulated><Encephalon><Engineering><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Florida><Freidreich's Ataxia><Friedreich Ataxia><Friedreich Disease><Friedreich Spinocerebellar Ataxia><Friedreich's Familial Ataxia><Friedreich's Hereditary Ataxia><Friedreich's Hereditary Spinal Ataxia><Friedreich's tabes><Gene Activation><Gene Targeting><Gene Transfer Clinical><Genes><Genetic Intervention><Genome><Goals><Health Care Systems><Hemato-Encephalic Barrier><Hereditary><Hereditary Spinal Sclerosis><Heterochromatin><Histone H3><Histones><Human><Inherited><International><Intervening Sequences><Introns><L-Lysine><Ligand Binding Protein><Ligand Binding Protein Gene><Lysine><Machine Intelligence><Machine Learning><Mediating><Methylation><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Mission><Modern Man><Molecular><Molecular Dynamics Simulation><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Nucleosomes><Other Genetics><Oxidative Stress><Patients><Phenotype><Physics><Plasmids><Population><Production><Protein Binding><Proteins><Recombinants><Research><System><Testing><Tissue Engineering><Transfection><Transgenic Mice><Trinucleotide Repeats><Triplet Repeats><United States><United States National Institutes of Health><Universities><Unscheduled DNA Synthesis><Upregulation><Work><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><autosome><bioengineered tissue><blood-brain barrier function><bloodbrain barrier><bloodbrain barrier function><bound protein><cellular differentiation><cerebral><codon reiteration><demethylation><design><designing><disability><effective therapy><effective treatment><engineered tissue><enhanced with AI><enhanced with Artificial Intelligence><epigenetically><fabrication><family ataxia><frataxin><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><histone demethylase><human disease><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><machine based learning><microfluidic chip><molecular dynamics><nano particle><nano-sized particle><nanoparticle><nanosized particle><neural><neurological disease><neuronal><next generation><novel><public health relevance><simulation><single cell analysis><single cell technology><three dimensional><tool>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jin He

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Exploratory lead · 40/100

Large award

Active award

$1,319,674

FY 2026

Project Title

CRISPR/dCas9-Targeted Histone Demethylation Interplays with DNA Repair to Contract GAA Repeats in Friedreich's Ataxia

Grant Number:

1RM1NS143850-01

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/26/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

Friedreich’s ataxia (FRDA) is the most common autosomal recessive ataxia. It is caused by expanded GAA repeats at the first intron of the frataxin (FXN) gene. No effective treatments are available for the disease due to the inherited expanded GAA repeats in the patient’s genome. Thus, there is an ur...

Research Terms

<3-D><3-Dimensional><3D><AI Augmented><AI assisted><AI driven><AI enhanced><AI integrated><AI powered><AI system><Affect><Architecture><Artificial Intelligence><Artificial Intelligence enhanced><Ataxia><Ataxy><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><BBB function><Base Excision Repairs><Basic Research><Basic Science><Binding Proteins><Biochemistry><Biological Chemistry><Blood - brain barrier anatomy><Blood-Brain Barrier><Brain><Brain Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiac><Cas nuclease technology><Cell Body><Cell Communication><Cell Differentiation><Cell Differentiation process><Cell Interaction><Cell-to-Cell Interaction><Cells><Cerebrum><Chemistry><Chromatin><Clinical Research><Clinical Study><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Computer Reasoning><Contracting Opportunities><Contracts><Coordination Impairment><Country><DNA Base Excision Repair><DNA Damage Repair><DNA Repair><DNA Therapy><Dimensions><Disease><Disorder><Dyssynergia><Encapsulated><Encephalon><Engineering><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Florida><Freidreich's Ataxia><Friedreich Ataxia><Friedreich Disease><Friedreich Spinocerebellar Ataxia><Friedreich's Familial Ataxia><Friedreich's Hereditary Ataxia><Friedreich's Hereditary Spinal Ataxia><Friedreich's tabes><Gene Activation><Gene Targeting><Gene Transfer Clinical><Genes><Genetic Intervention><Genome><Goals><Health Care Systems><Hemato-Encephalic Barrier><Hereditary><Hereditary Spinal Sclerosis><Heterochromatin><Histone H3><Histones><Human><Inherited><International><Intervening Sequences><Introns><L-Lysine><Ligand Binding Protein><Ligand Binding Protein Gene><Lysine><Machine Intelligence><Machine Learning><Mediating><Methylation><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Mission><Modern Man><Molecular><Molecular Dynamics Simulation><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Nucleosomes><Other Genetics><Oxidative Stress><Patients><Phenotype><Physics><Plasmids><Population><Production><Protein Binding><Proteins><Recombinants><Research><System><Testing><Tissue Engineering><Transfection><Transgenic Mice><Trinucleotide Repeats><Triplet Repeats><United States><United States National Institutes of Health><Universities><Unscheduled DNA Synthesis><Upregulation><Work><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><autosome><bioengineered tissue><blood-brain barrier function><bloodbrain barrier><bloodbrain barrier function><bound protein><cellular differentiation><cerebral><codon reiteration><demethylation><design><designing><disability><effective therapy><effective treatment><engineered tissue><enhanced with AI><enhanced with Artificial Intelligence><epigenetically><fabrication><family ataxia><frataxin><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><histone demethylase><human disease><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><machine based learning><microfluidic chip><molecular dynamics><nano particle><nano-sized particle><nanoparticle><nanosized particle><neural><neurological disease><neuronal><next generation><novel><public health relevance><simulation><single cell analysis><single cell technology><three dimensional><tool>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Cheng-Yu Lai

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Exploratory lead · 40/100

Large award

Active award

$1,319,674

FY 2026

Project Title

CRISPR/dCas9-Targeted Histone Demethylation Interplays with DNA Repair to Contract GAA Repeats in Friedreich's Ataxia

Grant Number:

1RM1NS143850-01

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/26/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

Friedreich’s ataxia (FRDA) is the most common autosomal recessive ataxia. It is caused by expanded GAA repeats at the first intron of the frataxin (FXN) gene. No effective treatments are available for the disease due to the inherited expanded GAA repeats in the patient’s genome. Thus, there is an ur...

Research Terms

<3-D><3-Dimensional><3D><AI Augmented><AI assisted><AI driven><AI enhanced><AI integrated><AI powered><AI system><Affect><Architecture><Artificial Intelligence><Artificial Intelligence enhanced><Ataxia><Ataxy><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><BBB function><Base Excision Repairs><Basic Research><Basic Science><Binding Proteins><Biochemistry><Biological Chemistry><Blood - brain barrier anatomy><Blood-Brain Barrier><Brain><Brain Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiac><Cas nuclease technology><Cell Body><Cell Communication><Cell Differentiation><Cell Differentiation process><Cell Interaction><Cell-to-Cell Interaction><Cells><Cerebrum><Chemistry><Chromatin><Clinical Research><Clinical Study><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Computer Reasoning><Contracting Opportunities><Contracts><Coordination Impairment><Country><DNA Base Excision Repair><DNA Damage Repair><DNA Repair><DNA Therapy><Dimensions><Disease><Disorder><Dyssynergia><Encapsulated><Encephalon><Engineering><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Florida><Freidreich's Ataxia><Friedreich Ataxia><Friedreich Disease><Friedreich Spinocerebellar Ataxia><Friedreich's Familial Ataxia><Friedreich's Hereditary Ataxia><Friedreich's Hereditary Spinal Ataxia><Friedreich's tabes><Gene Activation><Gene Targeting><Gene Transfer Clinical><Genes><Genetic Intervention><Genome><Goals><Health Care Systems><Hemato-Encephalic Barrier><Hereditary><Hereditary Spinal Sclerosis><Heterochromatin><Histone H3><Histones><Human><Inherited><International><Intervening Sequences><Introns><L-Lysine><Ligand Binding Protein><Ligand Binding Protein Gene><Lysine><Machine Intelligence><Machine Learning><Mediating><Methylation><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Mission><Modern Man><Molecular><Molecular Dynamics Simulation><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Nucleosomes><Other Genetics><Oxidative Stress><Patients><Phenotype><Physics><Plasmids><Population><Production><Protein Binding><Proteins><Recombinants><Research><System><Testing><Tissue Engineering><Transfection><Transgenic Mice><Trinucleotide Repeats><Triplet Repeats><United States><United States National Institutes of Health><Universities><Unscheduled DNA Synthesis><Upregulation><Work><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><autosome><bioengineered tissue><blood-brain barrier function><bloodbrain barrier><bloodbrain barrier function><bound protein><cellular differentiation><cerebral><codon reiteration><demethylation><design><designing><disability><effective therapy><effective treatment><engineered tissue><enhanced with AI><enhanced with Artificial Intelligence><epigenetically><fabrication><family ataxia><frataxin><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><histone demethylase><human disease><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><machine based learning><microfluidic chip><molecular dynamics><nano particle><nano-sized particle><nanoparticle><nanosized particle><neural><neurological disease><neuronal><next generation><novel><public health relevance><simulation><single cell analysis><single cell technology><three dimensional><tool>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Yuan Liu

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Exploratory lead · 40/100

Large award

Active award

$1,319,674

FY 2026

Project Title

CRISPR/dCas9-Targeted Histone Demethylation Interplays with DNA Repair to Contract GAA Repeats in Friedreich's Ataxia

Grant Number:

1RM1NS143850-01

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/26/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

Friedreich’s ataxia (FRDA) is the most common autosomal recessive ataxia. It is caused by expanded GAA repeats at the first intron of the frataxin (FXN) gene. No effective treatments are available for the disease due to the inherited expanded GAA repeats in the patient’s genome. Thus, there is an ur...

Research Terms

<3-D><3-Dimensional><3D><AI Augmented><AI assisted><AI driven><AI enhanced><AI integrated><AI powered><AI system><Affect><Architecture><Artificial Intelligence><Artificial Intelligence enhanced><Ataxia><Ataxy><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><BBB function><Base Excision Repairs><Basic Research><Basic Science><Binding Proteins><Biochemistry><Biological Chemistry><Blood - brain barrier anatomy><Blood-Brain Barrier><Brain><Brain Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiac><Cas nuclease technology><Cell Body><Cell Communication><Cell Differentiation><Cell Differentiation process><Cell Interaction><Cell-to-Cell Interaction><Cells><Cerebrum><Chemistry><Chromatin><Clinical Research><Clinical Study><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Computer Reasoning><Contracting Opportunities><Contracts><Coordination Impairment><Country><DNA Base Excision Repair><DNA Damage Repair><DNA Repair><DNA Therapy><Dimensions><Disease><Disorder><Dyssynergia><Encapsulated><Encephalon><Engineering><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Florida><Freidreich's Ataxia><Friedreich Ataxia><Friedreich Disease><Friedreich Spinocerebellar Ataxia><Friedreich's Familial Ataxia><Friedreich's Hereditary Ataxia><Friedreich's Hereditary Spinal Ataxia><Friedreich's tabes><Gene Activation><Gene Targeting><Gene Transfer Clinical><Genes><Genetic Intervention><Genome><Goals><Health Care Systems><Hemato-Encephalic Barrier><Hereditary><Hereditary Spinal Sclerosis><Heterochromatin><Histone H3><Histones><Human><Inherited><International><Intervening Sequences><Introns><L-Lysine><Ligand Binding Protein><Ligand Binding Protein Gene><Lysine><Machine Intelligence><Machine Learning><Mediating><Methylation><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Mission><Modern Man><Molecular><Molecular Dynamics Simulation><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Nucleosomes><Other Genetics><Oxidative Stress><Patients><Phenotype><Physics><Plasmids><Population><Production><Protein Binding><Proteins><Recombinants><Research><System><Testing><Tissue Engineering><Transfection><Transgenic Mice><Trinucleotide Repeats><Triplet Repeats><United States><United States National Institutes of Health><Universities><Unscheduled DNA Synthesis><Upregulation><Work><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><autosome><bioengineered tissue><blood-brain barrier function><bloodbrain barrier><bloodbrain barrier function><bound protein><cellular differentiation><cerebral><codon reiteration><demethylation><design><designing><disability><effective therapy><effective treatment><engineered tissue><enhanced with AI><enhanced with Artificial Intelligence><epigenetically><fabrication><family ataxia><frataxin><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><histone demethylase><human disease><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><machine based learning><microfluidic chip><molecular dynamics><nano particle><nano-sized particle><nanoparticle><nanosized particle><neural><neurological disease><neuronal><next generation><novel><public health relevance><simulation><single cell analysis><single cell technology><three dimensional><tool>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jef D BOEKE

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Exploratory lead · 40/100

Above-average budget

Recent

Active award

$844,954

FY 2026

Project Title

Genomically rewritten and tailored humanized mouse models for various organ disorders

Grant Number:

5R24OD037800-02

Activity Code:

R24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2025

End Date:

2/28/2029

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

Summary This proposal leverages Big DNA technology to produce mouse models of a variety of human diseases. The underlying hypothesis tested in our earlier work and continued in this proposal is that changes in human non- coding DNA that underlie human disease susceptibility will translate into appro...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Shane Liddelow

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Exploratory lead · 40/100

Above-average budget

Recent

Active award

$844,954

FY 2026

Project Title

Genomically rewritten and tailored humanized mouse models for various organ disorders

Grant Number:

5R24OD037800-02

Activity Code:

R24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2025

End Date:

2/28/2029

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

Summary This proposal leverages Big DNA technology to produce mouse models of a variety of human diseases. The underlying hypothesis tested in our earlier work and continued in this proposal is that changes in human non- coding DNA that underlie human disease susceptibility will translate into appro...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Yongqiang Feng

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

Exploratory lead · 40/100

Above-average budget

Recent

Active award

$508,750

FY 2026

Project Title

A method for engineering high-fidelity regulatory T cells

Grant Number:

1R21AI191010-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/13/2026

End Date:

1/31/2028

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Regulatory T cells (Tregs) dominantly suppress effector T cells, serving as a living therapeutic agent for immunological diseases such as type I diabetes and multiple sclerosis. However, Tregs exhibit a plastic fate at inflammatory conditions characterized by the loss of lineage identity an...

Research Terms

<3' Untranslated Regions><3'UTR><Address><Adoptive Transfer><Antigen Receptors><Antigens><Autoimmune Status><Autoimmunity><Bacteriophages><Basic Research><Basic Science><Brittle Diabetes Mellitus><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Creativeness><DNA><DNA Recombination><Deoxyribonucleic Acid><Differential Gene Expression><Disease><Disorder><Disseminated Sclerosis><Drugs><Engineering><Exhibits><FOXP3><FOXP3 gene><Face><Forkhead Box P3><Gene Expression><Gene Transcription><Genes><Genetic Recombination><Genetic Transcription><Germ Lines><Goals><High Affinity Interleukin-2 Receptor><Human><Human Engineering><IDDM><IL-2 Receptors><IL2 Receptors><IRES><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunes><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><In Vitro><Inflammation><Inflammatory><Initiation Codon><Initiator Codon><Injections><Insulin-Dependent Diabetes Mellitus><Integrase><Interleukin 2 Receptor><Internal Ribosome Entry Segment><Internal Ribosome Entry Site><Intervening Sequences><Introns><JM2><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Knock-in><MGF protein><MGSNF protein><MOG glycoprotein><Mediating><Medication><Methods><Mice><Mice Mammals><Modern Man><Mouse Strains><Multiple Sclerosis><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Outcome><Peptides><Performance><Phages><Pharmaceutical Preparations><Position><Positioning Attribute><Predisposition><Proteins><Protocol><Protocols documentation><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Receptor Signaling><Recombination><Regulatory T-Lymphocyte><Research><Resistance><Ribosome Entry Site><SCURFIN><STAT protein><STAT5><STAT5A><STAT5A gene><STAT5a Transcription Factor><Sampling><Signal Transducer and Activator of Transcription><Signal Transducer and Activator of Transcription 5A><Site><Sorting><Source><Start Codon><Stat5 protein><Stat5a protein><Stat5alpha protein><Stop Codon><Subcellular Process><Sudden-Onset Diabetes Mellitus><Surface><Susceptibility><System><Systems Integration><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cell Development><T-Cell Growth Factor Receptors><T-Cell Ontogeny><T-Cells><T-Lymphocyte><T-Lymphocyte Development><T-cell therapeutics><T-cell transfer therapy><T1 DM><T1 diabetes><T1D><T1DM><TCGF Receptors><Teff cell><Termination Codon><Terminator Codon><Testing><Therapeutic><Therapeutic Agents><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Transcription><Translation Stop Signal><Treg><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><UTRs><Uncertainty><Untranslated Regions><Variant><Variation><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><bacterial virus><chimeric antigen receptor><creativity><doubt><drug/agent><effector T cell><empowerment><engineered T cells><experiment><experimental research><experimental study><experiments><faces><facial><genetically engineered T-cells><genome editing><genomic editing><high risk><homologous recombination><immune suppression><immune suppressive activity><immune suppressive function><immunogen><immunosuppressive activity><immunosuppressive function><immunosuppressive response><innovate><innovation><innovative><insular sclerosis><insulin dependent diabetes><insulin dependent type 1><integrated system><integration site><interest><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><knockin><mammary gland factor><mammary gland-specific nuclear factor><myelin oligodendrocyte glycoprotein><neuronal><new approaches><novel approaches><novel strategies><novel strategy><oligodendrocyte-myelin glycoprotein><peptide immunization><peptide vaccination><prevent><preventing><programs><receptor><regulatory T-cells><resistant><response><signal tranducer and activator of transcription 5><system integration><therapeutic T-cell platform><thymus derived lymphocyte><tool><transcriptome sequencing><transcriptomic sequencing><transdifferentiation><transgenic T- cells><translational applications><type I diabetes><type one diabetes>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Moonjung Jung

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$372,282

FY 2026

Project Title

Protection of hematopoietic stem progenitor cells from endogenous DNA damage

Grant Number:

5R00HL177829-02

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/21/2025

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Maintaining genome integrity is critical for hematopoietic stem cells (HSCs) as they self-renew and differentiate into all blood cells throughout one’s life with enormous regenerative capacity. HSCs depend on the Fanconi anemia DNA repair pathway that removes DNA interstrand crosslin...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kathryn I Braden

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$82,348

FY 2026

Project Title

Investigating the role of dorsal raphe nucleus enkephalin neurons in motivational and affective behaviors during chronic pain

Grant Number:

5F32DA062455-02

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The primary goal of this NRSA F32 proposal is to determine the contribution of endogenous opioids in dorsal raphe nucleus to motivational and affective dysregulation during chronic pain. Chronic pain is a complex disease state which is associated with comorbidities such as depression...

Research Terms

<21+ years old><Absence of pain sensation><Absence of sensibility to pain><Acute><Acute Pain><Acutely painful><Adult><Adult Human><Affect><Affective><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Animals><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Anxiety><Applications Grants><Area><Behavior><Behavioral><Behavioral Assay><Biological><Blood><Blood Reticuloendothelial System><Brain><Brain Nervous System><Brain region><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Color><Communities><Complex><Coupled><DREADDs><Data><Development><Disease><Disorder><Dorsal><Dysfunction><Emotional><Emotions><Encephalon><Endoscopy><Enkephalins><Epidemic><Feels no pain><Functional disorder><Goals><Grant Proposals><Human><Individual><Intracellular Communication and Signaling><Investigators><Journals><Label><Learning><Ligands><Magazine><Mental Depression><Mesencephalic Central Gray><Mesencephalon><Mice><Mice Mammals><Mid-brain><Midbrain><Midbrain Central Gray><Midbrain structure><Modern Man><Monitor><Motivation><Murine><Mus><NRSA><National Research Service Awards><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuropathy><Neurosciences><No sensitivity to pain><Nociception><Nucleus><Odors><Opiate Peptides><Opiates><Opioid><Opioid Peptide><Pain><Painful><Pathologic><Pattern><Peptides><Periaqueductal Gray><Peripheral><Permeability><Phenotype><Photons><Physiopathology><Population><Process><Publications><Research><Research Personnel><Researchers><Rewards><Role><Saccharose><Saline><Saline Solution><Scientific Publication><Scientist><Self Administered><Self Administration><Signal Transduction><Signal Transduction Systems><Signaling><Site><Spinal><Sucrose><System><Technology><Therapeutic><Therapeutic Intervention><Time><Training><United States><Universities><Viral><Virus><Washington><Work><Writing><adulthood><allodynia><analgesia><annulus of the aqueduct><anxiety-like behavior><behavior test><behavioral test><biologic><biological signal transduction><calcium indicator><chronic pain><co-morbid><co-morbidity><comorbidity><conditioned place preference><conference><convention><depression><designer receptors exclusively activated by designer drugs><developmental><dorsal raphe nucleus><endogenous opiate><endogenous opioids><endoscopic imaging><experience><experiment><experimental research><experimental study><experiments><fluorophore><in vivo><insight><intervention therapy><knock-down><knockdown><midbrain central gray substance><mood regulation><motivated behavior><nerve injury><neural><neural circuit><neural circuitry><neural injury><neurochemical><neurochemistry><neurocircuitry><neuronal><neuropathic><neuropathic pain><next generation><nociceptive><novel><pain behavior><pain catastrophizing><pain killer><pain medication><pain relief><pain reliever><painful neuropathy><painkiller><pathophysiology><periaqueductal gray matter><place conditioning><pre-proenkephalin><prepro-enkephalin><preproenkephalin><pro-enkephalin><proenkephalin><redshift><relieve pain><response><sensory mechanism><side effect><skills><social role><spared nerve><spontaneous pain><suicidal risk><suicide risk><summit><symposia><symposium><synaptic circuit><synaptic circuitry><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic evaluation><therapeutic testing><training opportunity>

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Elektra Kantzari Robinson

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$81,580

FY 2026

Project Title

Understanding mechanisms by which microbially derived metabolites regulate host gut inflammation.

Grant Number:

5F32DK138598-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary: Chronic inflammation is a rising health issue that affects millions of people worldwide. Emerging evidence shows that dysbiosis of the gut microbiota can lead to changes in the production of microbial-derived metabolites (MDMs), which contribute to inflammation and the onset of infl...

Research Terms

<(TNF)-α><5-HTP><5-hydroxy-tryptophan><Acids><Acute><Acute Disease><Address><Affect><Animal Model><Animal Models and Related Studies><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Autoregulation><Beta Proprotein Interleukin 1><Biochemical Pathway><Biochemistry><Biological Chemistry><Biology><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR interference><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR-dCas9-mediated repression><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Cachectin><Calibration><Cancers><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cells><Chemical Structure><Chemicals><Chronic><Circulation><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats interference><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Colonic inflammation><Cues><DNA mutation><Data><Development><Diabetes Mellitus><Dietary Intervention><Dietary fiber fermentation><Disease><Disorder><ELISA><Ecologic Systems><Ecological Systems><Ecosystem><Enzyme-Linked Immunosorbent Assay><Fluorescence><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GI microbiota><GPCR><Gastrointestinal microbiota><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genomic approach><Gnotobiotic><Gnotobiotics><Health><Histology><Homeostasis><Human><Human Biology><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immune system><Immunes><Immunochemical Immunologic><Immunologic><Immunologic Diseases><Immunological><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunologically><Immunologics><Immunomodulation><In Vitro><Individuality><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Interleukin 1beta><Interleukin-1 beta><Interleukin-1β><Intervention Studies><Intestinal><Intestines><Intracellular Communication and Signaling><Investigators><Knock-in><Knock-out><Knockout><Knowledge><Learning Skill><Libraries><Location><Macrophage><Macrophage-Derived TNF><Malignant Neoplasms><Malignant Tumor><Measures><Medicine><Mentors><Metabolic Networks><Metabolic Pathway><Mice><Mice Mammals><Microbe><Microbial Genetics><Modeling><Modern Man><Molecular><Molecular Genetics><Monocyte-Derived TNF><Murine><Mus><Mutation><Mφ><NAFLD><Nutrient><Nutrition Interventions><Nutritional Interventions><Oxitriptan><Oxytryptophan><Pathway interactions><Persons><Physiological Homeostasis><Precision therapeutics><Preinterleukin 1 Beta><Production><Property><Proteins><Publishing><Receptor Protein><Regulatory Pathway><Reporter><Research><Research Personnel><Researchers><Role><Science of Microbial Genetics><Series><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Strains Cell Lines><Syndrome><System><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Technology><Testing><Tissues><Training><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Universities><Volatile Fatty Acids><Work><absorption><acute disease/disorder><acute disorder><biological signal transduction><bowel><bowel inflammation><career><cell type><chemical colitis><chemical induction of colitis><chemically induced colitis><comparative genomics><cultured cell line><developmental><diabetes><diet intervention><dietary fiber digestion><enteric microbial community><enteric microbiota><enzyme linked immunoassay><experience><experiment><experimental research><experimental study><experiments><gain of function><gastrointestinal microbial flora><genome mutation><genomic effort><genomic strategy><gut community><gut dysbiosis><gut flora><gut inflammation><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiota><gut microbiotic><gut microflora><host microbe association><host microbe relationship><host microbiota><host microflora><host response><host-microbe interactions><host-microbial interactions><host-microorganism interactions><humanized mice><humanized mouse><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><in vivo><inflamed bowel><inflamed colon><inflamed gut><inflamed intestine><inflammation marker><inflammatory disease of the intestine><inflammatory disorder of the intestine><inflammatory marker><interdisciplinary approach><intervention research><interventional research><interventional study><interventions research><intestinal autoinflammation><intestinal flora><intestinal inflammation><intestinal microbiota><intestinal microflora><intestinal tract microflora><knockin><malignancy><metabolism measurement><metabolomics><metabonomics><microbial><microbial consortia><microbial flora><microbial host><microbiota><microflora><microorganism><microorganism genetics><model of animal><mouse model><multidisciplinary approach><multispecies consortia><murine model><neoplasm/cancer><non-alcohol fatty liver disease><non-alcoholic fatty liver disease><non-alcoholic liver disease><nonalcoholic fatty liver disease><novel><pathway><precision therapies><precision treatment><prevent><preventing><receptor><repressing CRISPR-dCas9 system><resident microbes><resident microflora><social role><tool><translational pipeline><translational spectrum>

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Jordan Trent Roach

UNIVERSITY OF TENNESSEE HEALTH SCI CTR, MEMPHIS, TN

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$54,854

FY 2026

Project Title

Identifying a transcriptional core regulatory circuitry and other critical transcription factor dependencies in H3.3 G34R/V high-grade glioma

Grant Number:

5F30CA271570-05

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Pediatric high-grade gliomas (HGGs) are devastating central nervous system malignancies. Despite decades of investigation into these lethal childhood brain tumors, aggressive surgical resection combined with conventional chemotherapy and radiation therapy remains the standard of care...

Research Terms

<0-11 years old><ATAC sequencing><ATAC-seq><ATACseq><Abscission><Address><Adolescent and Young Adult><Age><Anatomic Sites><Anatomic structures><Anatomy><Apoptotic><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biological Assay><Biology><Brain><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><CNS Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR correction><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based correction><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Cause><Cancer Etiology><Cancers><Cas nuclease technology><Cas9-based correction><Cas9-mediated correction><Causality><Cell Body><Cell Growth in Number><Cell Line><Cell Multiplication><Cell Proliferation><Cell Survival><Cell Viability><CellLine><Cells><Cellular Proliferation><Central Nervous System><Cerebral cortex><ChIP Sequencing><ChIP-seq><ChIPseq><Chemotherapy and Radiation><Chemotherapy and/or radiation><Child><Child Youth><Childhood><Childhood Brain Neoplasm><Childhood Brain Tumor><Childhood Cancers><Childhood Glioma><Children (0-21)><Chromatin><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Collection><Complex><Connector Neuron><DNA Binding><DNA Binding Domain><DNA Binding Interaction><DNA Methylation><DNA bound><DNA mutation><DNA-Binding Protein Motifs><Data><Dependence><Development><Developmental Gene><Disease><Disorder><Encephalon><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Essential Genes><Etiology><Excision><Exclusion><Exhibits><Expression Signature><Extirpation><Frequencies><Functional dependence><Gene Expression><Gene Expression Profile><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genomics><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioma><Heterograft><Heterologous Transplantation><Histone H3><Histone H3.3><Immunoblotting><In Situ Nick-End Labeling><Individual><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Investigation><Label><Laboratories><Malignant Cell><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Neoplasms><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant Tumor><Malignant childhood cancer><Maps><Mediating><Mentors><Modeling><Molecular><Molecular Fingerprinting><Molecular Profiling><Morbidity><Mutate><Mutation><Neoplastic Colony-Forming Units><Neoplastic Stem Cells><Nerve Cells><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neuroglial Neoplasm><Neuroglial Tumor><Neurons><Oncogenesis><Oncogenic><Operative Procedures><Operative Surgical Procedures><Patients><Pattern><Pediatric Glioma><Pediatric high-grade glioma><Physiologic><Physiological><Post-Transcriptional Gene Silencing><Primary Neoplasm><Primary Tumor><Progenitor Cells><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><RNA Expression><RNA Interference><RNA Seq><RNA Silencing><RNA sequencing><RNAi><RNAseq><Radiation therapy><Radiotherapeutics><Radiotherapy><Recurrence><Recurrent><Removal><Research><Role><Sequence-Specific Posttranscriptional Gene Silencing><Short interfering RNA><Specific qualifier value><Specified><Stem Cell like><Strains Cell Lines><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><TUNEL><Techniques><Therapeutic><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Cell><Tumor Stem Cells><Western Blotting><Western Immunoblotting><Xenograft><Xenograft procedure><Xenotransplantation><ages><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><cancer cell><cancer in a child><cancer in children><causation><chemo/radiation therapy><chemotherapy and radiotherapy><child with cancer><childhood malignancy><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><clinical training><cultured cell line><curative intervention><curative therapeutic><curative therapy><curative treatments><developmental><disease causation><epigenetically><experience><gene expression pattern><gene expression signature><genome mutation><genome scale><genome-wide><genomewide><genomic platform><glial-derived tumor><glioma cell line><human progenitor><human stem cells><improved><kids><knock-down><knockdown><loss of function><malignancy><member><molecular profile><molecular signature><mortality><mutant><neoplasm/cancer><neoplastic cell><neuro-oncology><neuroglia neoplasm><neuroglia tumor><neuronal><neurooncology><neurosurgery><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><pediatric><pediatric brain neoplasm><pediatric brain tumor><pediatric cancer><pediatric malignancy><progenitor capacity><progenitor cell like><progenitor cell model><progenitor model><progenitor-like><programs><protein blotting><qRTPCR><radiation or chemotherapy><radiation treatment><resection><siRNA><social role><spatial and temporal><spatial temporal><spatiotemporal><standard of care><stem and progenitor cell model><stem cell based model><stem cell characteristics><stem cell derived model><stem cell model><stem cells><stem-like><stemness><surgery><terminal nick end labeling><transcription factor><transcriptional profile><transcriptional signature><transcriptome sequencing><transcriptomic sequencing><treatment with radiation><tumor><tumor progenitor><tumorigenesis><tumors in the brain><xeno-transplant><xeno-transplantation><youngster>

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Maggie Marie Kane

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$50,114

FY 2026

Project Title

Mechanisms of NBR2, a Long Non-Coding RNA, in Human Ovarian Aging

Grant Number:

1F31AG099640-01

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT This research proposal is in response to the NOT-OD-24-079 “Notice of Special Interest: Women’s Health Research” focused on health conditions that are female-specific. The ovary is the first organ to age in the human body. Ovarian aging negatively influences lifespan and a b...

Research Terms

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Mason T Myers

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$43,589

FY 2026

Project Title

Leveraging a 'sliding-window' Type I CRISPR base editing platform to correct CFTR null mutations

Grant Number:

5F31HL177911-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Cystic Fibrosis (CF) is an autosomal recessive genetic disorder affecting nearly 160,000 patients worldwide. It is caused by mutations in the CF transmembrane conductance regulator (CFTR) gene, which encodes a chloride ion channel crucial for salt and water homeostasis across epithel...

Research Terms

<1H-Purin-6-amine><Adenine><Adverse effects><Affect><Ailmentary System><Alimentary System><Alleles><Allelomorphs><Arginine><Assay><Autoregulation><Bioassay><Biological Assay><CF patients><CFTR><CFTR Protein><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Line><CellLine><Cells><Chloride Channels><Chloride Ion Channels><ClinVar><Clinical><Clone Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><Computer Analysis><Cystic Fibrosis><Cystic Fibrosis Transmembrane Conductance Regulator><DNA><DNA Double Strand Break><DNA Therapy><DNA mutation><Data Bases><Databases><Deaminase><Deoxyribonucleic Acid><Development><Digestive System><Disease><Disorder><Drug Modulation><Drug Therapy><Drugs><Dysfunction><Effectiveness><Electrophysiology><Electrophysiology (science)><Electroporation><Epithelial Cells><Epithelium><FDA approved><Face><Fluid Balance><Fluid Homeostasis><Functional disorder><Gastrointestinal Body System><Gastrointestinal Organ System><Gene Transfer Clinical><Genes><Genetic><Genetic Change><Genetic Diseases><Genetic Intervention><Genetic defect><Genetic mutation><Genome engineering><Genotype><Goals><Guanine><Guide RNA><Hb SS disease><HbSS disease><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Homeostasis><Human><Hydrogen Oxide><Impairment><Individual><Intestinal><Intestines><Ions><Ivacaftor><L-Arginine><Length><Life><Lung><Lung Respiratory System><Lung damage><Measures><Mediating><Medical><Medication><Membrane><Messenger RNA><Modeling><Modern Man><Monitor><Morbidity><Mucous body substance><Mucoviscidosis><Mucus><Mutation><Neurophysiology / Electrophysiology><Non-Polyadenylated RNA><Nonsense Codon><Organoids><Outcome Measure><Pancreas><Pancreatic><Pathogenicity><Patients><Persons><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiological Homeostasis><Physiology><Physiopathology><Premature Stop Codon><Property><Proteins><RNA><RNA Gene Products><Regulator Genes><Ribonucleic Acid><Safety><Sickle Cell Anemia><Site><Slide><Societies><Sodium Chloride><Strains Cell Lines><Swelling><System><Testing><Therapeutic><Therapeutic Gene Editing><Transcriptional Regulatory Elements><VX-770><Variant><Variation><Vitamin B4><Water><autosome><base><base editing><base editor><bases><bowel><bronchial epithelium><burden of disease><burden of illness><computational analyses><computational analysis><computer analyses><cost><cultured cell line><cystic fibrosis patients><cystic fibrosis transmembrane regulator><data base><deep sequencing><design><designing><developmental><disease burden><drug detection><drug development><drug intervention><drug testing><drug treatment><drug/agent><electrophysiological><electroporative delivery><faces><facial><flexibility><flexible><functional restoration><gRNA><gastrointestinal system><gene corrected><gene correction><gene editing method><gene editing methodology><gene editing platform><gene editing strategy><gene editing system><gene editing techniques><gene editing technology><gene editing tools><gene electrotransfer><gene locus><gene null><gene repair therapy><gene therapy><gene-based therapy><gene-editing approach><gene-editing therapy><gene-editing toolkit><genetic condition><genetic disorder><genetic locus><genetic recessive><genetic therapy><genetic trans acting element><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genome mutation><genomic correction><genomic location><genomic locus><genomic therapy><individuals with CF><individuals with cystic fibrosis><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><lung injury><mRNA><measurable outcome><membrane structure><mortality><mucous><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><nuclease><null mutation><off-target site><outcome measurement><pathophysiology><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient-derived pluripotent stem cells><patients with CF><patients with cystic fibrosis><pharmaceutical><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pre-clinical><preclinical><protein function><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><recessive genetic trait><recessive trait><regulatory gene><restoration><restore function><restore functionality><restore lost function><salt><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><side effect><stoichiometry><success><synergism><theories><therapeutic editing><therapeutic genome editing><therapeutic outcome><therapy outcome><tool><trans acting element><unpublished works>

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Deirdre Logsdon

UNIVERSITY OF COLORADO, Boulder, CO

Exploratory lead · 34/100

Training-friendly

Active award

$79,300

FY 2026

Project Title

Defining the link between trisomy 21 and placentation defects

Grant Number:

5F32HD116568-02

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Down’s Syndrome (T21) is the most common aneuploidy disorder in humans. T21 pregnancies are at an increased risk of adverse pregnancy outcomes including stillbirth and intrauterine growth restriction resulting from placental insufficiency. T21 is also accompanied by comorbidities including congenita...

Research Terms

<1st trimester><21+ years old><2nd trimester><3'5'-cyclic ester of AMP><AVSD><Abnormal placentation><Address><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adult><Adult Human><Affect><Age><Aneuploid><Aneuploidy><Anti-Estrogens><Aquadiol><BMP4><Binding><Body System><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Candidate Disease Gene><Candidate Gene><Cardiac><Cardiac Malformation><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac defect><Cardiocyte><Cas nuclease technology><Causality><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><Cell fusion><CellLine><Cells><Cells Placenta-Tissue><Chromosome 21><Chromosomes><Chronic Disease><Chronic Illness><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Coleonol><Conditioned Culture Media><Conditioned Medium><Cre Lox technology><Cre LoxP system><Cre lox recombination><Cre lox recombination system><Cre lox system><Cre recombinase/LoxP technology><Cre system><Culturing, in vitro Vertebrate, Primary><Cyclic AMP><Defect><Development><Diagnosis><Differentation Markers><Differentiation Antigens><Differentiation Markers><Dimenformon><Diogyn><Diogynets><Disease><Disorder><Dose><Down Syndrome><Dysfunction><ERalpha><ERα><ESR1><ESR1 gene><Early Placental Phase><Estrace><Estradiol><Estradiol Receptor alpha><Estradiol Receptor α><Estradiol-17 beta><Estradiol-17beta><Estraldine><Estrogen Antagonists><Estrogen Receptor 1><Estrogen Receptor alpha><Estrogen Receptor α><Estrogen Receptors><Estrogens><Etiology><Exposure to><Fetal Growth Restriction><Fetal Growth Retardation><First Pregnancy Trimester><First Trimester><Forskolin><Foundations><Functional disorder><Future><Gene Transcription><Genes><Genetic Transcription><Gestation><Goals><Health><Heart><Heart Malformation><Heart Muscle Cells><Heart myocyte><Human><IUGR><Immunofluorescence><Immunofluorescence Immunologic><Impairment><In Vitro><Incidence><Individual><Individuals with down syndrome><Intracellular Communication and Signaling><Intrauterine Growth Retardation><Langdon Down syndrome><Life><Link><Marker Antigens><Maternal-Fetal Exchange><Measures><Mediating><Membrane><Mice><Mice Mammals><Midtrimester><Modeling><Modern Man><Molecular><Molecular Interaction><Mongolism><Morphology><Murine><Mus><NR3A1><NRIP1><NRIP1 gene><Normal Placentoma><Nuclear Receptor Interacting Protein 1><Organ System><Ovocyclin><Ovocylin><Pathology><Persons><Phenocopy><Phenotype><Physiopathology><Placenta><Placenta Embryonic Tissue><Placental Development><Placental Insufficiency><Placentation><Placentome><Pregnancy><Primary Cell Cultures><Progynon><RIP140><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Receptor Inhibition><Receptor Interacting Protein 140><Reporting><Repression><Research><Risk><Role><Second Pregnancy Trimester><Second Trimester><Signal Transduction><Signal Transduction Systems><Signaling><Strains Cell Lines><Syncytiotrophoblast><Techniques><Testing><Therapeutic Estradiol><Therapeutic Estrogen><Therapeutic Intervention><Tissues><Transcript><Transcription><Transplacental Exposure><Trisomy><Trisomy 21><abnormal heart development><adenosine 3'5' monophosphate><adulthood><adverse pregnancy outcome><ages><antiestrogen><antiestrogenic><atrioventricular canal defect><atrioventricular septal defect><biological signal transduction><cAMP><cardiomyocyte><causation><chromosome 21 trisomy><chromosome 21 trisomy syndrome><chronic disorder><co-morbid><co-morbidity><comorbidity><congenital acromicria syndrome><congenital cardiac abnormality><congenital cardiac anomalies><congenital cardiac disease><congenital cardiac disorder><congenital cardiac malformation><congenital heart abnormality><congenital heart anomaly><congenital heart disease><congenital heart disorder><congenital heart malformation><critical congenital heart disease><cultured cell line><developmental><differential expression><differentially expressed><differentiation protocol><disease causation><disease phenotype><dosage><down syndrome individuals><down syndrome patients><estrogen inhibitor><experiment><experimental research><experimental study><experiments><fetal><global gene expression><global transcription profile><heart defect><iPS><iPSC><iPSCs><impaired fetal growth><implantation><improved><in utero><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><intervention therapy><intra-uterine growth restriction><intra-uterine growth retardation><intrauterine growth restriction><knock-down><knockdown><later in life><later life><lentiviral-transduced><lentivirally transduced><lentivirus transduced><malformation><maternal-fetal interface><membrane structure><morbus Down><overexpress><overexpression><pathophysiology><patients with down syndrome><people with down syndrome><placental trophoblasts><prenatal growth disorder><programs><pseudohypertrophic progressive muscular dystrophy><risk mitigation><sex><social role><stillbirth><stillborn><transcriptional differences><transcriptome><transcriptome sequencing><transcriptomic sequencing><trisomy 21 syndrome><trophoblast>

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Jada Summerville

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Exploratory lead · 34/100

Training-friendly

Active award

$50,114

FY 2026

Project Title

Non-Canonical Roles for Cell-Adhesion Molecules in Presynaptic Assembly

Grant Number:

5F31NS134338-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/15/2023

End Date:

12/14/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The proper formation of synapses is integral to the function of neural circuits. Disruptions in synaptogenesis during early development can lead to neurodevelopmental disorders, such as autism or intellectual disability. Yet despite decades of study, precisely how synapses form, matu...

Research Terms

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Mira N Antonopoulos

UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 34/100

Training-friendly

Active award

$49,538

FY 2026

Project Title

Targeting transcription and translation of the antisense CCCCGG repeat expansion in C9ORF72 ALS/FTD

Grant Number:

5F31NS141619-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Amyotrophic lateral sclerosis (ALS) and frontotemporal degeneration (FTD) are devastating neurodegenerative diseases with no cure to date. The most common genetic cause of ALS/FTD is a hexanucleotide GGGGCC (G4C2) repeat expansion mutation in the C9ORF72 gene. The repeat is transcrib...

Research Terms

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Ainul Huda

VIRGINIA POLYTECHNIC INST AND ST UNIV, BLACKSBURG, VA

Exploratory lead · 34/100

Training-friendly

Active award

$45,503

FY 2026

Project Title

Understanding the Molecular Mechanisms of Thermoreceptors

Grant Number:

5F31NS139648-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/23/2025

End Date:

1/22/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Temperature significantly influences physiological processes and behaviors, impacting chemical reactions, biomolecule activity, and species distribution. Mosquitoes, vectors of diseases like malaria and dengue, are responsive to temperature cues, shaping survival, reproduct...

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Curtis Ryan Carlson

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Exploratory lead · 34/100

Training-friendly

Active award

$43,471

FY 2026

Project Title

Investigating the molecular mechanisms underlying sleep disruption in Smith-Kingsmore Syndrome

Grant Number:

1F31NS147396-01

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2026

End Date:

11/30/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Smith-Kingsmore Syndrome (SKS) is a recently discovered human genetic disorder caused by gain-of-function mutations in the mechanistic target of rapamycin (mTOR) gene. SKS patients exhibit variable symptoms, including sleep disruptions, intellectual disability, developmental...

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Nathan Tharp

RICE UNIVERSITY, HOUSTON, TX

Exploratory lead · 34/100

Training-friendly

Active award

$33,003

FY 2026

Project Title

Investigating PEX11 roles in shaping peroxisome architecture and dynamics

Grant Number:

5F31GM150269-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/5/2024

End Date:

7/4/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Investigating the role of PEX11 in peroxisome architecture Peroxisomes are critical organelles housing numerous metabolic reactions including fatty acid β-oxidation and reactive oxidative species decomposition. Although peroxisomes are classically thought to be single membrane-bound organelles enclo...

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Matthew Brewer

IOWA STATE UNIVERSITY, AMES, IA

Exploratory lead · 32/100

Solid budget

Recent

Active award

$453,063

FY 2026

Project Title

Overcoming innate drug efflux systems to expand anthelmintic vulnerability

Grant Number:

1R21AI190535-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/13/2026

End Date:

1/31/2028

Project Abstract

Project Summary Nematode parasites are present nearly every place in the world inhabited by humans. Our strategy for controlling these diseases is to use small molecule therapy, however, there has not been a new drug class on the market in 40 years. We propose that endogenous transporter systems of ...

Research Terms

<21+ years old><ABC Transport Protein><ABC Transporter Protein><ABC Transporters><ABC20><ABCB1><ABCB1 gene><ATP-Binding Cassette Transporters><Address><Adult><Adult Human><Amino Acids><Anthelmintics><Antihelminthic Agent><Antihelminthic Drugs><Antiparasitic Agents><Antiparasitic Drugs><Antiparasitics><Ascaris><Binding><Blood - brain barrier anatomy><Blood-Brain Barrier><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Isolation><Cell Line><Cell Segregation><Cell Separation><Cell Separation Technology><CellLine><Cells><Cessation of life><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collection><Communicable Diseases><Cytometry><Death><Defense Mechanisms><Disease><Disorder><Drug Efflux><Drugs><Eukaryotic Cell><Exhibits><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Face><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Future><GP170><GeneHomolog><Genes><Glycoproteins><Goals><Hemato-Encephalic Barrier><Homolog><Homologous Gene><Homologue><Human><Image Cytometry><Impoverished><Individual><Infectious Diseases><Infectious Disorder><Intestinal><Intestines><Investigators><Kidney><Kidney Urinary System><Knock-out><Knockout><Knowledge><Larva><Lead><Libraries><Licensing><Life Cycle><Life Cycle Stages><Liver><MDR-1><MDR1><MDR1 Protein><Mammalia><Mammals><Marketing><Measures><Mediating><Medication><Messenger RNA><Mission><Modern Man><Molecular Interaction><Molecular Target><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><NIH><National Institutes of Health><Nature><Nematoda><Nematodes><Outcome><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PGY-1 Protein><PGY1><Parasites><Parasitic nematode><Parasiticides><Pb element><Pharmaceutical Preparations><Pharmacological Study><Pharmacology><Pharmacology Study><Phenotype><Physiology><Population><Poverty><Property><RNA Seq><RNA sequencing><RNAseq><Research Personnel><Researchers><Rest><Scientist><Strains Cell Lines><System><Techniques><Toxin><United States National Institutes of Health><Vermifuges><Xenobiotics><adulthood><aminoacid><antihelminthic><bloodbrain barrier><bowel><cell sorting><cultured cell line><develop drug resistance><disease control><disorder control><drug resistance development><drug/agent><efflux pump><faces><facial><frontier><global gene expression><global transcription profile><heavy metal Pb><heavy metal lead><hepatic body system><hepatic organ system><improved><inhibitor><innovate><innovation><innovative><life course><long read seq><long-read sequencing><long-read transcript sequencing><mRNA><mutant><neglect><new drug class><novel><novel drug class><parasitic roundworm><prevent><preventing><psychological defense mechanism><renal><restoration><roundworm><seal><tool><transcriptome><transcriptome sequencing><transcriptomic sequencing>

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Francis Alonzo

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Exploratory lead · 32/100

Solid budget

Recent

Active award

$440,908

FY 2026

Project Title

Extracellular Vesicle Inspired Nano Vesicles for CRISPR-based Targeting of MRSA

Grant Number:

1R21AI197496-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2026

End Date:

1/31/2028

Project Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) strains are antibiotic resistant bacteria that are the leading cause of healthcare associated infections in the United States and around the world. While research has focused on the development of new and more powerful antibiotics, the strains keep ...

Research Terms

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Sriram Ravindran

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Exploratory lead · 32/100

Solid budget

Recent

Active award

$440,908

FY 2026

Project Title

Extracellular Vesicle Inspired Nano Vesicles for CRISPR-based Targeting of MRSA

Grant Number:

1R21AI197496-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2026

End Date:

1/31/2028

Project Abstract

Methicillin-resistant Staphylococcus aureus (MRSA) strains are antibiotic resistant bacteria that are the leading cause of healthcare associated infections in the United States and around the world. While research has focused on the development of new and more powerful antibiotics, the strains keep ...

Research Terms

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Omar Sultan Akbari

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 32/100

Solid budget

Recent

Active award

$439,375

FY 2026

Project Title

MitoPac female killing systems in mosquitoes

Grant Number:

1R21AI196522-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/19/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Dengue, chikungunya, and Zika are diseases transmitted by Aedes aegypti. One strategy to reduce Ae. aegypti populations is to release non-biting male mosquitoes that pass female killing genes to their progeny. Over time and with many releases, this can lead to a significant suppress...

Research Terms

<A. aegypti><Address><Ades aegypti><Advanced Development><Ae. Aegypti><Aedes aegypti><Anopheles><Anopheles Genus><Anophelines><Automobile Driving><Biology><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Coupled><Culicidae><DNA Restriction Enzymes><Data><Data Set><Dengue><Development><Development and Research><Disease Vectors><Drosophila><Drosophila genus><Elements><Engineering><Ensure><Essential Genes><Feasibility Studies><Female><Future><Gene Expression><Gene Transcription><Genes><Genetic><Genetic Transcription><Genome engineering><Goals><Health><Heat Shock><Heat-Shock Reaction><Heat-Shock Response><Human><Insecta><Insects><Insects Invertebrates><Intervening Sequences><Introns><Location><Malaria><Mitochondria><Mitochondrial DNA><Modeling><Modern Man><Mosquito Control><Mosquito-borne disease><Mosquito-borne infectious disease><Mosquitoes><Ortholog><Orthologous Gene><Paludism><Phenotype><Plasmodium Infections><Polycomb><Population><Population Study><R & D><R&D><RNA Expression><Regulation><Regulatory Element><Research><Response Elements><Restriction Endonucleases><Sex Ratio><Specificity><System><Technology><Temperature><Tetracyclines><Time><Toxin><Transcription><Transmission><Work><ZIKV disease><Zika virus disease><chikungunya><cold temperature><communicable disease transmission><design><designing><developmental><disease transmission><driving><expectation><experience><fitness><flexibility><flexible><fruit fly><genetic technology><human pathogen><improved><infectious disease transmission><innovate><innovation><innovative><low temperature><male><mitochondrial><mtDNA><novel><pathogen><population research study><population survey><population-based study><population-level study><promoter><promotor><research and development><selective expression><selectively expressed><sex><tech development><technology development><timeline><tool><transmission process><vector><vector mosquito><zika disease><♀><♂>

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Yifan Wang

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 32/100

Solid budget

Recent

Active award

$411,780

FY 2026

Project Title

Deciphering Virulence Determinants of Human-Pathogenic Atypical Toxoplasma gondii

Grant Number:

1R21AI187670-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/3/2026

End Date:

1/31/2028

Project Abstract

1 PROJECT SUMMARY 2 3 Apicomplexan parasites are a major cause of mortality and morbidity in humans and animals. As a 4 model apicomplexan parasite, Toxoplasma gondii is highlighted by the CDC as the 2nd leading cause of 5 foodborne illness in the US and is classified as an NIAID Emerging/Re-eme...

Research Terms

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Joshua John Breunig

CEDARS-SINAI MEDICAL CENTER, LOS ANGELES, CA

Exploratory lead · 32/100

Solid budget

Recent

Active award

$404,788

FY 2026

Project Title

Enabling in vivo barcoded single-cell multiomics-compatible genome-wide screens in personalized tumor models using defined-copy somatic transgenesis

Grant Number:

5R33CA278564-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/8/2024

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY / ABSTRACT CRISPR technology have massively expanded our ability to interrogate the genetic mechanisms of cancer and define therapeutic avenues. Techniques have evolved over the past five years for the generation of massive scale CRISPR genetic screens linked to single cell transcrip...

Research Terms

<0-11 years old><3-D><3-Dimensional><3D><Abscission><Advanced Development><Applications Grants><Bar Codes><Biological><Biology><Brain Neoplasia><Brain Neoplasms><Brain Tumors><CRISPR><CRISPR activation><CRISPR activator><CRISPR approach><CRISPR based activation><CRISPR based approach><CRISPR editing screen><CRISPR gene activation><CRISPR method><CRISPR methodology><CRISPR screen><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-CAS-9><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-based method><CRISPR-based screen><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR-dCAS9 Activator><CRISPR-mediated transcriptional activation><CRISPR/CAS approach><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 screen><CRISPR/Cas9 technology><CRISPR/dCas9 activation><CRISPR/dCas9-based transcriptional activation><CRISPRa><Cancer Cause><Cancer Etiology><Cancers><Cas nuclease technology><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chemicals><Chemotherapy and Radiation><Chemotherapy and/or radiation><Child><Child Youth><Children (0-21)><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><DNA Insertion Elements><DNA mutation><Electroporation><Elements><Engineering><Ependymoma><Evolution><Excision><Extirpation><Gene Transfer Techniques><Generalized Growth><Generations><Genes><Genetic><Genetic Change><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Screening><Genetic defect><Genetic mutation><Genomics><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioblastoma><Glioma><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Grant Proposals><Growth><Hour><Human><Human Engineering><Immunocompetent><In Vitro><Intracellular Communication and Signaling><Intratumoral heterogeneity><Learning><Libraries><Lineage Tracing><Link><Malignant Neoplasms><Malignant Tumor><Mediating><Methodology><Methods><Mice><Mice Mammals><Modeling><Modern Man><Modernization><Molecular><Murine><Mus><Mutation><NFKB3><Neuroglial Neoplasm><Neuroglial Tumor><ORFs><Oncogenesis><Open Reading Frames><Organoids><Patients><Plasmids><Protein Coding Region><Proteins><RELA><RELA gene><Radiation therapy><Radiotherapeutics><Radiotherapy><Recombinant DNA Technology><Recurrence><Recurrent><Removal><Reporter><Resistance><Resolution><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Somatic Mutation><Supratentorial><Surgical Removal><Survival Rate><System><Techniques><Technology><Temodal><Temodar><Testing><Therapeutic><Tissue Growth><Transgenesis><Transgenic Organisms><Validation><Variant><Variation><Viral><WHO Grade II Ependymal Neoplasm><WHO Grade II Ependymal Tumor><Work><activating CRISPR technology><adult youth><anti-cancer research><barcode><biologic><biological signal transduction><cancer research><cancer type><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><chemo/radiation therapy><chemotherapy and radiotherapy><clustered regularly interspaced short palindromic repeats screen><cost effective><diffuse midline glioma><driver lesion><driver mutation><electroporative delivery><experience><experiment><experimental research><experimental study><experiments><fitness><gain of function><gene electrotransfer><gene locus><genetic element><genetic locus><genetically engineered><genome editing><genome mutation><genome wide screen><genomic editing><genomic location><genomic locus><glial-derived tumor><glioblastoma multiforme><global gene expression><global transcription profile><heterogeneity in tumors><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human model><iPS><iPSC><iPSCs><immune competent><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insertion element><insertion sequence><insight><intra-tumoral heterogeneity><intratumor heterogeneity><kids><large scale data><large scale data sets><large scale datasets><life history><loss of function><malignancy><methazolastone><model of human><mosaic analysis><multiomics><multiple omics><neoplasm/cancer><neuroglia neoplasm><neuroglia tumor><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><panomics><radiation or chemotherapy><radiation treatment><rapid method><rapid technique><recombinase><recombinase-mediated cassette exchange><recombination-mediated cassette exchange><resection><resistant><resolutions><scRNA sequencing><scRNA-seq><screening><screenings><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell next generation sequencing><single cell sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><somatic variant><spongioblastoma multiforme><standard of care><temozolomide><three dimensional><tool><transcriptome><transcriptomics><transgenic><treatment with radiation><tumor><tumor heterogeneity><tumorigenesis><tumors in the brain><validations><young adult><young adult age><young adulthood><youngster>

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Naama Aviram

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Exploratory lead · 30/100

Very recent

Active award

$249,000

FY 2026

Project Title

Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systems

Grant Number:

5R00GM148720-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary CRISPR-Cas are prokaryotic adaptive immune systems that protect bacteria and archaea from invading mobile genetic elements, such as phages and plasmids. CRISPR-Cas systems acquire immunological memories during infection by integrating short fragments from the invader’s genome into th...

Research Terms

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Nicole D. Marino

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 30/100

Very recent

Active award

$249,000

FY 2026

Project Title

Discovery of novel phage-bacterial interactions

Grant Number:

5R00GM143476-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/7/2021

End Date:

12/31/2026

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Interactions between bacteria and their viruses (phages) are among the most ubiquitous in nature and have yielded transformative tools for genetic engineering, such as restriction enzymes and CRISPR-Cas. More than three dozen new bacterial immune systems have recently been discovered...

Research Terms

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KEITH R JEROME

FRED HUTCHINSON CANCER CENTER, SEATTLE, WA

Exploratory lead · 30/100

Very recent

Active award

$232,558

FY 2026

Project Title

AAV-delivered meganucleases for durable control of genital HSV disease

Grant Number:

1R21AI195413-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/13/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project summary Herpes simplex virus (HSV) establishes latency in ganglionic neurons of the peripheral nervous system. Latent HSV can later reactivate, causing recurrent disease and possible transmission to new hosts. Current anti-HSV therapy is inadequate, in that it does not eliminate latent HSV, ...

Research Terms

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William Tswenching Pu

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Exploratory lead · 30/100

Very recent

Active award

$202,920

FY 2026

Project Title

A modular system for murine CRISPR genome and epigenome editing

Grant Number:

5R21OD037909-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary RNA-guided DNA sequence recognition by CRISPR/Cas9 has been exploited to develop an array of genome and epigenome editors, including base editors, primer editors, CRISPR-activators (CRISPR-a) and CRISPR-interference (CRISPR-i). These editors consist of either nuclease dead (dCas9) o...

Research Terms

<1H-Purin-6-amine><AAV delivered><AAV delivery><AAV vector><AAV-based delivery><AAV-based vector><AAV-based viral delivery><AAV-mediated delivery><Adenine><Adeno-Associated Viruses><Adeno-associated-virus-based delivery><Biocompatible Materials><Biological Function><Biological Process><Biology><Biomaterials><Body Tissues><C-terminal><CRISPR><CRISPR activation><CRISPR activator><CRISPR approach><CRISPR based activation><CRISPR based approach><CRISPR editing screen><CRISPR gene activation><CRISPR interference><CRISPR method><CRISPR methodology><CRISPR screen><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-CAS-9><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-based method><CRISPR-based screen><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR-dCAS9 Activator><CRISPR-dCas9-mediated repression><CRISPR-mediated transcriptional activation><CRISPR/CAS approach><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 screen><CRISPR/Cas9 technology><CRISPR/dCas9 activation><CRISPR/dCas9 interference><CRISPR/dCas9-based transcriptional activation><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRa><CRISPRi><Canine Species><Canis familiaris><Cas nuclease technology><Chimera Protein><Chimeric Proteins><Closure by Ligation><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats interference><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cultured Cells><Cytosine Aminohydrolase><Cytosine deaminase><DNA><DNA Nicking Enzyme><DNA Sequence><Deaminase><Deoxyribonucleic Acid><Dependoparvovirus><Dependovirus><Development><Disease><Disorder><Dogs><Dogs Mammals><EC 2.7.7.49><Elements><Endonuclease I><Engineering><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Fusion Protein><Gene Delivery><Gene Modified><Genetic Screening><Genome><Genomics><Guide RNA><Intervening Protein Sequence><Ligation><LoxP-flanked allele><Mediating><Mice><Mice Mammals><Modification><Murine><Mus><Names><Nickase><Protein Introns><Protein Splicing><Proteins><RNA Transcriptase><RNA-Dependent DNA Polymerase><RNA-Directed DNA Polymerase><Reagent><Research><Reverse Transcriptase><Revertase><Site><Specificity><System><Technology><Testing><Therapeutic Gene Editing><Time><Tissues><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcription Repressor><Transcriptional Activator/Coactivator><Transcriptional Repressor><Transgenes><Transgenic Mice><Treatment Efficacy><Variant><Variation><Vitamin B4><activating CRISPR technology><adeno associated virus group><adeno-associated viral vector><adeno-associated viral vector delivery><adeno-associated virus delivery><adeno-associated virus mediated delivery><adeno-associated virus vector><adenovirus mediated delivery><animal model development><base editing><base editor><biological material><canine><clustered regularly interspaced short palindromic repeats screen><delivered with AAV><delivery with AAV><developmental><domestic dog><empowerment><epigenetically><epigenome><epigenome editing><epigenomic editing><flexibility><flexible><floxed><floxed allele><gRNA><gene delivery system><gene modification><gene-editing therapy><genetic repressor><genetically modified><genome editing><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genomic editing><improved><in vivo><intein><intervention efficacy><name><named><naming><novel><nuclease><prime editing><prime editor><rate of change><repressing CRISPR-dCas9 system><therapeutic editing><therapeutic efficacy><therapeutic genome editing><therapy efficacy><tool><transgene><vector>

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Jialiang Liang

UNIVERSITY OF CINCINNATI, CINCINNATI, OH

Exploratory lead · 30/100

Very recent

Active award

$202,500

FY 2026

Project Title

Engineering RNA biodevices for precise modulation of fibroblasts to boost cardiac reprogramming

Grant Number:

5R21HL177541-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY: Myocardial infarction (MI)-induced cardiovascular diseases remain a major global cause of death. Post-MI excessive fibrosis can lead to adverse remodeling and eventual heart failure. Unfortunately, there are limited therapies to prevent fibrosis and hinder heart failure progression. In vivo...

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Ralph R. Isberg

TUFTS UNIVERSITY BOSTON, BOSTON, MA

Exploratory lead · 30/100

Very recent

Active award

$199,506

FY 2026

Project Title

Optical Sequencing to Link Quantitative Bacterial Phenotypes to Human Mutations

Grant Number:

5R21AI190788-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Numerous bacterial pathogens, such as Legionella pneumophila, grow within host cells during disease. Pathogen growth within cells allows them to grow in a protected site, sequestered from attack by inflammatory cells and protected from antibody attack. In spite of these advantages, the host cell has...

Research Terms

<Ab-mediated immunity><Ab-mediated protection><Antibody immunity><Antibody protection><Antibody-mediated protection><Autophagocytosis><Bacteria><Behavior><Binding><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><Cell membrane><CellLine><Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cytoplasm><Cytoplasmic Membrane><Cytosol><DNA mutation><DNA seq><DNA sequencing><DNAseq><Data><Defect><Disease><Disorder><Dissection><Endoplasmic Reticulum><Ergastoplasm><Failure><Fe element><Fluorescence Light Microscopy><Fluorescence Microscopy><Gene Targeting><Generalized Growth><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genotype><Goals><Growth><Human><Image><Individual><Inflammatory><Intracellular Communication and Signaling><Iron><Knock-out><Knockout><L pneumophila><L. pneumophila><Laboratories><Legionella><Legionella pneumophila><Libraries><Link><Manuals><Measures><Membrane><Microscope><Microscopic><Microscopy><Mitochondria><Modern Man><Molecular Interaction><Mutation><Mutation Analysis><Nutritional><Nutritional Immunity><Optics><Organism><Pathway interactions><Phagocytes><Phagocytic Cell><Phenotype><Phorbol Esters><Plasma Membrane><Play><Process><Property><Protein translocation><Proteins><Reporter><Reproducibility><Role><Running><Signal Transduction><Signal Transduction Systems><Signaling><Site><Starvation><Statistical Methods><Strains Cell Lines><System><T4SS><Technology><Testing><Tissue Growth><Transmembrane Protein Transport><Type IV Secretion System><Type IV Secretion System Pathway><U937 Cells><UV laboratory microscope><Ultraviolet Microscopes><Vacuole><Visualization><Work><amebocyte><anti-microbial><antibody-mediated immunity><antimicrobial><autophagy><bacteria pathogen><bacterial fitness><bacterial pathogen><biological signal transduction><cell fixing><comparative><cultured cell line><deep sequencing><experiment><experimental research><experimental study><experiments><fitness><fluorescence microscope><fluorescence/UV microscope><fluorescent microscope><genome mutation><imaging><in situ sequencing><innate immune sensing><laboratory fluorescence light microscope><living system><membrane structure><mitochondrial><monolayer><mutant><nutritious><ontogeny><optical><pathogen><pathogenic bacteria><pathway><plasmalemma><prevent><preventing><sequencing platform><social role><statistic methods><tool><trait><type 4 secretion system>

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ARIANNA L KIM

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 30/100

Very recent

Active award

$192,259

FY 2026

Project Title

Targeting Tumor-Driven Immune Tolerance to Overcome Resistance to Hedgehog Inhibition

Grant Number:

5R21CA301201-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Patients with basal cell nevus syndrome (BCNS) typically develop hundreds of basal cell carcinomas (BCCs) due to germline mutations that drive aberrant activation of the Hedgehog (Hh) signaling pathway. Affected individuals develop tumors even in early childhood and are at substantially incr...

Research Terms

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Narendra Wajapeyee

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 30/100

Very recent

Active award

$173,559

FY 2026

Project Title

A Novel Approach to Enhance Therapeutic Efficacy of Tarlatamab for Small Cell Lung Cancer Treatment

Grant Number:

5R21CA298890-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Small cell lung cancer (SCLC) is a highly aggressive form of lung cancer with a dismal survival rate. The response of SCLC to current therapies is short-lived and the disease progression is inevitable in most patients. Furthermore, unlike other lung cancer types, there is a notable s...

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Walter Isaiah Adams

SAN JOSE STATE UNIVERSITY, SAN JOSE, CA

Exploratory lead · 30/100

Very recent

Active award

$146,500

FY 2026

Project Title

Mechanism of Toxin Mediated Damage to the Lung Epithelium during S. pneumoniae Infection

Grant Number:

5R16AI182337-03

Activity Code:

R16

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Streptococcus pneumoniae causes over 150,000 hospitalizations annually in the U.S., with a mortality rate of 5- 7%, making the disease both a significant health and financial burden. A key virulence factor during S. pneumoniae infection is pneumolysin (PLY), a cholesterol dependent c...

Research Terms

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JENNIFER R CURTISS

NEW MEXICO STATE UNIVERSITY LAS CRUCES, LAS CRUCES, NM

Exploratory lead · 30/100

Very recent

Active award

$145,948

FY 2026

Project Title

Determining the role of a TENT5 family non-canonical polyA polymerase in Drosophila spermatogenesis

Grant Number:

5R16GM153674-03

Activity Code:

R16

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Translational repression and reactivation play critical roles in the development and homeostasis of multicellular organisms. These processes have been best studied in oocytes, which are often generated but not fertilized for weeks, months or even years. Studies of Xenopus oo...

Research Terms

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Matthew Gilbert Oser

DANA-FARBER CANCER INST, BOSTON, MA

Exploratory lead · 26/100

Solid budget

Active award

$459,546

FY 2026

Project Title

Mechanisms by which LSD1 Promotes Neuroendocrine Differentiation and Small Cell Lung Cancer

Grant Number:

5R37CA269990-04

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/6/2022

End Date:

11/30/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Small cell lung cancer (SCLC) is a high-grade neuroendocrine tumor currently without any approved targeted therapies. Inhibitors of the histone demethylase LSD1 are currently in clinical trials in SCLC inspired by strong preclinical data demonstrating that some SCLCs are hi...

Research Terms

<3' Untranslated Regions><3'UTR><ACSL1><ACSL1 Gene><AOF2><ASCL1><ASCL1 gene><ASCL1 protein><ASH1><Achaete-Scute Complex Homolog-Like 1 Protein><Achaete-Scute Complex-Like 1 Protein><Achaete-Scute Homolog 1 Protein><Binding><Binding Proteins><Biological><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Patient><Cancer cell line><Cancers><Cas nuclease technology><Cell Line><CellLine><Chromatin><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><Data><Engineering><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Extracellular Signal-Regulated Kinase Gene><Foundations><GEM model><GEMM model><Gene Down-Regulation><Gene Expression><Genes><Genetic><Genetic study><Genetically Engineered Mouse><Goals><HASH1><HASH1 protein><Immunocompetent><In Vitro><Induction of Apoptosis><KDM1A><KDM1A gene><LSD1><Laboratories><Ligand Binding Protein><Ligand Binding Protein Gene><Link><Lysine-Specific Demethylase 1><Lysine-Specific Demethylase 1A><MAP Kinase Gene><MAPK><MASH 1 protein><MASH1><MASH1 protein><MEK inhibition><Malignant Neoplasms><Malignant Tumor><Mammalian Achaete-Scute Homolog 1><Messenger RNA><Mice><Mice Mammals><Minority><Mitogen-Activated Protein Kinase Gene><Modeling><Molecular><Molecular Interaction><Murine><Mus><Neuroendocrine><Neuroendocrine Cell><Neuroendocrine Neoplasm><Neuroendocrine System><Neuroendocrine Tumors><Neurosecretory Systems><Oat cell carcinoma><Oncogenesis><PDX model><Pathway interactions><Patient Selection><Patient derived xenograft><Pre-Clinical Model><Preclinical Models><Preclinical data><Principal Investigator><Proliferating><Protein Binding><Repression><Research><Resistance><Strains Cell Lines><Testing><Therapeutic><Transcription Repression><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><Validation><Writing><biologic><bound protein><cultured cell line><derepression><epigenetically><experiment><experimental research><experimental study><experiments><gene locus><gene repression><genetic locus><genetically engineered mouse model><genetically engineered murine model><genome scale><genome-wide><genomewide><genomic location><genomic locus><histone demethylase><hypoimmunity><immune competent><immune deficiency><immunodeficiency><immunogenicity><in vivo><inhibitor><insight><loss of function><lung oat cell carcinoma><lung small cell neuroendocrine carcinoma><mRNA><malignancy><mouse model><murine model><mutant><neoplasm/cancer><neuroendocrine differentiation><neuroendocrine phenotype><novel><oat cell cancer><pathway><patient derived xenograft model><pre-clinical><preclinical><preclinical findings><preclinical information><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><resistant><screening><screenings><selective expression><selectively expressed><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><treatment strategy><tumor><tumor initiation><tumorigenesis><ubiquitin ligase><validations>

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Piyush K Jain

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 26/100

Solid budget

Active award

$411,727

FY 2026

Project Title

A rapid CRISPR-based self-testing platform for early detection of HIV

Grant Number:

5R61AI181016-03

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/19/2024

End Date:

12/31/2026

Project Abstract

PROJECT ABSTRACT/SUMMARY In 2018 alone, the WHO reported 1.7 million new cases and estimated 770,000 HIV-related deaths due to gaps in HIV services. Early detection of HIV would allow quicker intervention and can significantly reduce the risk of death and further transmission. Therefore, this propo...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><AIDS><AIDS Virus><AIDS focused research><AIDS related research><AIDS research><AIDS science><AIDS specific research><AIDS test><AIDS/HIV test><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Advanced HIV><Antibodies><Assay><Binding><Bioassay><Biological Assay><Blood Plasma><Blood Sample><Blood Serum><Blood Volume><Blood specimen><COVID detection><COVID-19 detection><COVID-19 virus><COVID19 detection><COVID19 virus><CRISPR><CRISPR/Cas system><Cell Body><Cell Phone><Cells><Cellular Phone><Cellular Telephone><Cessation of life><Clinic><Clinical><Clinical Evaluation><Clinical Testing><Clinical assessments><Clustered Regularly Interspaced Short Palindromic Repeats><CoV-2><CoV2><Cohort Studies><Coupled><Cytolysis><DNA><DNA amplification><Data><Death><Deoxyribonucleic Acid><Detection><Development><Devices><Diagnostic><Diagnostic Reagent Kits><Disease Outbreaks><Early Diagnosis><Early Intervention><Early treatment><Engineering><Enrollment><Env trimer><Equipment><Eye><Eyeball><FRET><Feedback><Fingers><Fluorescence><Fluorescence Resonance Energy Transfer><Freeze Drying><Freeze Dryings><Förster Resonance Energy Transfer><Genes><Goals><HCV><HIV><HIV Env><HIV envelope><HIV envelope protein><HIV focused research><HIV glycoprotein Env><HIV in patients><HIV individuals><HIV infected individuals><HIV infected persons><HIV investigation><HIV patient><HIV people><HIV positive individuals><HIV positive patient><HIV positive people><HIV related research><HIV research><HIV science><HIV specific research><HIV test><HIV-1><HIV-1 Env><HIV-1 envelope><HIV-1 glycoprotein Env><HIV-1 test><HIV-2 test><HIV-I><HIV1><Hepatitis C virus><Home><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Human immunodeficiency virus infected patients><Human immunodeficiency virus positive patients><Human immunodeficiency virus test><Infection><Intervention><Investigation on HIV><LAV-HTLV-III><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Lymphadenopathy-Associated Virus><Lyophilization><Lysis><Magnetism><Methods><Microfluidic Device><Microfluidic Lab-On-A-Chip><Microfluidic Microchips><Microfluidics><Mobile Phones><Molecular Interaction><Monitor><Non-Polyadenylated RNA><Nucleic Acids><Ortholog><Orthologous Gene><Outbreaks><PLWH><PWH><Paper><Participant><Patient Compliance><Patients><Patients living with HIV><Patients suffering from HIV><Performance><Phase><Pilot Projects><Plasma><Plasma Serum><Preparation><RNA><RNA Gene Products><Reaction><Reagent><Recommendation><Reporter><Reporting><Research Resources><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Reticuloendothelial System, Serum, Plasma><Ribonucleic Acid><Risk Reduction><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 detection><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Saliva><Sampling><Sensitivity and Specificity><Serum><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe HIV Disease><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Specificity><Survey Instrument><Surveys><System><Technology><Temperature><Testing><Transmission><Virus-HIV><World Health Organization><Wuhan coronavirus><alcohol related research><alcohol research><clinical test><cohort research study><cohort survey><coronavirus detection><coronavirus disease 2019 detection><coronavirus disease 2019 virus><coronavirus disease detection><coronavirus disease-19 virus><cost><death risk><detect COVID><detect COVID-19><detect COVID19><detect SARS-CoV-2><detect coronavirus><detect coronavirus disease><detect severe acute respiratory syndrome coronavirus 2><detection limit><detection platform><detection system><developmental><diagnostic approach><diagnostic kit><diagnostic platform><diagnostic strategy><diagnostic system><early detection><early therapy><enroll><env Genes><ethanol research><experience><hCoV19><high reward><high risk><homes><human immunodeficiency virus patient><human immunodeficiency virus research><iPhone><improved><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><innovate><innovation><innovative><instrumentation><lateral flow assay><lateral flow test><magnetic><magnetic beads><microfluidic chip><mortality risk><nCoV2><new approaches><novel approaches><novel strategies><novel strategy><nuclease><nucleic acid detection><patient adherence><patient cooperation><patient infected with HIV><patient with HIV><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><pilot study><point of care><point-of-care diagnostics><preparations><prevent><preventing><recruit><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><research addressing HIV><research clinical testing><research in HIV><research into HIV><research on HIV><research on human immunodeficiency virus><research to address HIV><risk-reducing><science on HIV><science to address HIV><self testing><severe acute respiratory syndrome coronavirus 2 detection><smart phone><smartphone><studies on HIV><test kit><thermophile><thermophilic organism><transmission process><usability><user-friendly><validation studies><viral RNA><virus RNA><µfluidic>

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ALAN George Smulian

UNIVERSITY OF CINCINNATI, CINCINNATI, OH

Exploratory lead · 26/100

Solid budget

Active award

$398,810

FY 2026

Project Title

Development of a Molecular Toolbox for Pneumocystis

Grant Number:

5R61AI187097-02

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2027

Project Abstract

Abstract Pneumocystis jirovecii (Pj) is a fungal pathogen responsible for pneumonia (PjP) in immunocompromised individuals. Understanding the pathobiology of the organism and its infection is limited by the inability to cultivate pneumocystis outside the mammalian lung and a lack of molecular tools ...

Research Terms

<3-D><3-Dimensional><3D><AIDS Virus><Abscission><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Amino Acids><Animals><Antigen Switching><Antigenic Determinants><Antigenic Switching><Binding Determinants><Biology><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Surface Glycoproteins><Cell Wall><Characteristics><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Common Rat Strains><Complex><D-Glucan><DNA><DNA Packaging><DNA Recombination><DNA mutation><Deoxyribonucleic Acid><Development><Drugs><Elements><Epidemic><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epitopes><Essential Genes><Excision><Extirpation><Extracellular Signal-Regulated Kinase Gene><Family member><Fluorochrome><Folate><Folic Acid><Frequencies><Gene Action Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Generalized Growth><Genes><Genetic><Genetic Change><Genetic Recombination><Genetic Transcription><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genomics><Glutamic Acid><Goals><Growth><HIV><Human><Human Immunodeficiency Viruses><Immune><Immune Evasion><Immune system><Immunes><Immunocompetent><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Individual><Infection><Interstitial Plasma Cell Pneumonia><Investigators><Knock-in><Knock-out><Knockout><L-Glutamic Acid><L-Threonine><LAV-HTLV-III><Label><Life Cycle><Life Cycle Stages><Lung><Lung Respiratory System><Lymphadenopathy-Associated Virus><MAP Kinase Cascades><MAP Kinase Gene><MAP Kinase Modules><MAP Kinase Signaling Cascades><MAP kinase><MAPK><Mediating><Medication><Membrane Glycoproteins><Methodology><Methods><Mice><Mice Mammals><Mitogen-Activated Protein Kinase Gene><Mitogen-Activated Protein Kinases><Modern Man><Modernization><Modification><Molecular><Murine><Mus><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Organism><Ortholog><Orthologous Gene><P. carinii><P. jirovecii><P. jirovecii Pneumonia><Partner in relationship><Pathogenesis><Pathway interactions><Pharmaceutical Preparations><Phase><Phenylalanine><Pheromone><Phosphorylation><Plasmids><Play><Pneumocystis><Pneumocystis Infections><Pneumocystis Pneumonia><Pneumocystis carini><Pneumocystis carinii><Pneumocystis carinii Infections><Pneumocystis carinii Pneumonia><Pneumocystis jirovecii><Pneumocystis jirovecii pneumonia><Pneumocystosis><Pneumonia><Preventative strategy><Prevention strategy><Preventive strategy><Proliferating><Protein Phosphorylation><Proteins><Pteroylglutamic Acid><RNA Expression><Rat><Rats Mammals><Rattus><Recombinant Proteins><Recombination><Removal><Reporter Genes><Research><Research Personnel><Researchers><Resistance><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><SMX><Sexual Reproduction><Signal Pathway><Site><Sulfamethoxazole><Sulfamethylisoxazole><Sulfisomezole><Surface Glycoproteins><Surgical Removal><System><Techniques><Technology><Terminator Regions><Terminator Sequence><Threonine><Time><Tissue Growth><Transcript><Transcription><Transcriptional Terminator Regions><Transmission><Virus-HIV><Vitamin M><Work><aminoacid><constitutive expression><constitutive gene expression><developmental><drug/agent><epigenetically><extracellular vesicles><fungal pathogen><fungi pathogen><fungus><gene editing platform><gene editing system><gene editing technology><gene editing tools><gene manipulation><gene product><gene-editing toolkit><genetic manipulation><genetic termination sequence><genetic terminator element><genetically manipulate><genetically perturb><genome analysis><genome mutation><global gene expression><global transcription profile><immune competent><immune evasive><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressed><immunosuppressed patient><immunosuppressive activity><immunosuppressive function><immunosuppressive response><in vivo><innovate><innovation><innovative><knockin><knockout gene><life course><living system><mate><ontogeny><overexpress><overexpression><pathogen><pathogenic fungus><pathway><plasmid DNA><polyglucosan><prevent><preventing><promoter><promotor><protein expression><resection><resistant><response><sex><social role><termination sequence><three dimensional><tool><transcriptome><transmission process><vitamin Bc><β-Glucans>

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Abbey Blake

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Exploratory lead · 24/100

Training-friendly

$17,283

FY 2026

Project Title

Evaluating the Role of Human Obesity Genes in Specific Neuronal Populations in vivo by CRISPRi

Grant Number:

5F31DK137538-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2024

End Date:

12/31/2025

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT ABSTRACT Obesity leads to an increased risk for type 2 diabetes, heart attack, hypertension, stroke, and many types of cancer—conditions which are among the leading causes of death in the US. Through twin and family studies, obesity has been found to have a 40-70% heritability rate, pointing...

Research Terms

<21+ years old><ACTH-beta-Lipotropin Precursor><Ablation><Adeno-Associated Viruses><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><Alleles><Allelomorphs><Alstrom syndrome><Alstrom-Hallgren syndrome><Alström Syndrome><Anatomic Sites><Anatomic structures><Anatomy><Apoplexy><Arcuate Nucleus><Autoregulation><Bardet Biedel syndrome><Bardet-Biedl Syndrome><Body Weight><Brain Vascular Accident><CRISPR><CRISPR interference><CRISPR-dCas9-mediated repression><CRISPR/Cas system><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Cancers><Cardiac infarction><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Membrane Extensions><Cell Membrane Projections><Cell Membrane Protrusions><Cell Signaling><Cell Surface Extensions><Cell Surface Projections><Cell Surface Protrusions><Cell model><Cells><Cellular model><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cilia><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats interference><Complex><Corticotropin-beta-Lipotropin Precursor><DNA mutation><Data><Defect><Dependoparvovirus><Dependovirus><Development><Down-Regulation><Eating><Endorphin-ACTH Precursor><Epistasis><Epistatic Deviation><Family Study><Food Intake><Gene Alteration><Gene Down-Regulation><Gene Expression><Gene Mutation><Gene Transcription><Genes><Genetic Change><Genetic Diversity><Genetic Epistasis><Genetic Transcription><Genetic Variation><Genetic defect><Genetic mutation><Guide RNA><Heritability><Homeostasis><Human><Hypertension><Hypothalamic structure><Hypothalamus><Infundibular Nucleus><Interaction Deviation><Intracellular Communication and Signaling><Ketosis-Resistant Diabetes Mellitus><Laboratories><Leptin><MC4 Receptor><Malignant Neoplasms><Malignant Tumor><Maturity-Onset Diabetes Mellitus><Mediating><Melanocortin 4 Receptor><Mice><Mice Mammals><Modeling><Modern Man><Morbid Obesity><Murine><Mus><Mutation><Myocardial Infarct><Myocardial Infarction><NIDDM><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Ob Gene Product><Ob Protein><Obese Gene Product><Obese Protein><Obesity><Organelles><Output><Paraventricular Hypothalamic Nucleus><Patients><Persons><Physiologic><Physiological><Physiological Homeostasis><Population><Pro-ACTH-Endorphin><Pro-Opio-Melanocortin><Pro-Opiocortin><Pro-Opiomelanocortin><Proopiocortin><Proopiomelanocortin><Proteins><Public Health><Quality Control><RNA Expression><Receptor, Melanocortin, Type 4><Regulation><Research><Research Proposals><Risk><Role><Severe obesity><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Specificity><Stable Diabetes Mellitus><Stroke><Structure of nucleus infundibularis hypothalami><System><T2 DM><T2D><T2DM><Technology><Testing><Therapeutic><Transcription><Transcription Repression><Twin Studies><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Validation><Variant><Variation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Work><adeno associated virus group><adenylyl cyclase III><adenylyl cyclase type III><adiposity><adult onset diabetes><adulthood><biological signal transduction><brain attack><cancer type><cardiac infarct><cell type><cerebral vascular accident><cerebrovascular accident><ciliopathy><coronary attack><coronary infarct><coronary infarction><corpulence><developmental><epistatic interaction><epistatic relationship><extreme obesity><family focused study><family survey><gRNA><gene defect><gene manipulation><gene repression><gene x gene interaction><genetic epistases><genetic etiology><genetic manipulation><genetic mechanism of disease><genetically manipulate><genetically perturb><genome mutation><heart attack><heart infarct><heart infarction><high blood pressure><human disease><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><hypothalamic><improved><in vivo><induced Cre><inducible Cre><ketosis resistant diabetes><malignancy><maturity onset diabetes><mutant allele><neoplasm/cancer><neuronal><paraventricular nucleus><repressing CRISPR-dCas9 system><social role><stroked><strokes><tool><type 2 DM><type II DM><type two diabetes><validations>

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Saba Parvez

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Exploratory lead · 22/100

Recent

Active award

$249,000

FY 2026

Project Title

In vivo functional screen of noncoding genetic elements

Grant Number:

5R00HG012593-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2024

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY It has been almost two decades since the completion of the Human Genome Project, yet much of the genome remains poorly understood. In particular, the function of most of the noncoding genome, which makes up almost 98% of the human genome, is unknown. To be sure, these noncoding seque...

Research Terms

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Hao Li

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Exploratory lead · 22/100

Recent

Active award

$249,000

FY 2026

Project Title

Determining how neurotensin mediates valence processing and compulsive cocaine seeking

Grant Number:

5R00DA055111-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT A hallmark of substance use disorders is continued drug use despite profound adverse consequences. While studies in rodents have suggested that leveraging both positive and negative valence processing can affect this compulsive pattern of reward-seeking behavior in conflict ...

Research Terms

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REBECCA M SHANSKY

NORTHEASTERN UNIVERSITY, BOSTON, MA

Exploratory lead · 22/100

Recent

Active award

$197,000

FY 2026

Project Title

The path to the parous brain: allopregnanolone-mediated mechanisms at GABAA receptors.

Grant Number:

5R21MH138857-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

Project Summary By age 49, nearly 85% of women in the US will have given birth at least once. The pregnancy and postpartum periods are marked by extreme hormonal fluctuations that can induce long-lasting changes in the brain, but mechanistic insight into how the unique hormonal milieu that character...

Research Terms

<21+ years old><3rd trimester><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><Adult><Adult Human><Age><Allopregnanolone><Aminalon><Aminalone><Animals><Area><Behavior><Behavioral><Binding><Birth><Brain><Brain Nervous System><Brain region><CNS plasticity><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Communication and Signaling><Cell Signaling><Child Rearing><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Common Rat Strains><Corpus Luteum Hormone><Cues><DREADDs><Data><Decision Making><Delta4-pregnene-3,20-dione><Development><Discipline of Nursing><Encephalon><Endocrine Gland Secretion><Ensure><Exhibits><Fiber><First Births><Freezing><GABA><Genetic><Gestation><Goals><Hormonal><Hormones><Hyperactivity><Individual><Intracellular Communication and Signaling><Knock-out><Knockout><Last Trimester><Late pregnancy><Learning><Link><Long-Term Effects><Measures><Medial><Mediating><Memory><Modeling><Molecular Interaction><Neural Inhibition><Neurobiology><Neuronal Plasticity><Neurosciences Research><Nulliparas><Nulliparity><Nulliparous><Nursing><Nursing Field><Nursing Profession><Parenting><Parenting behavior><Parturition><Phenotype><Photometry><Play><Population><Postpartum Period><Prefrontal Cortex><Pregn-4-ene-3,20-dione><Pregnancy><Pregnenedione><Primiparity><Process><Progesterone><Rat><Rats Mammals><Rattus><Receptor Protein><Reporting><Reproductive Process><Rodent><Rodentia><Rodents Mammals><Role><Signal Transduction><Signal Transduction Systems><Signaling><Stress><Testing><Therapeutic Hormone><Therapeutic Progesterone><Third Pregnancy Trimester><Third Trimester><Time><Weaning><Woman><Work><adulthood><after pregnancy><ages><biological signal transduction><central nervous system plasticity><childrearing><conditioned fear><designer receptors exclusively activated by designer drugs><developmental><emotion regulation><emotional regulation><executive control><executive function><experience><experiment><experimental research><experimental study><experiments><fear conditioning><gamma-Aminobutyric Acid><hormones associated with pregnancy><hormones during pregnancy><hormones in pregnancy><insight><neural><neural plasticity><neuroactive steroids><neurobiological><neurogenesis><neuroplastic><neuroplasticity><neurosteroids><parous><pharmacologic><positive allosteric modulator><post pregnancy><post-partum><pre-clinical><preclinical><pregnancy associated hormones><pregnancy hormones><pregnancy related hormones><pregnant><prepregnancy><prevent><preventing><primipara><primiparous><receptor><receptor binding><receptor bound><social role><tool><γ-Aminobutyric Acid>

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Elizabeth (Betsy) Schock

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Exploratory lead · 22/100

Recent

Active award

$154,000

FY 2026

Project Title

Elucidating the etiology for Schneckenbecken dysplasia, a rare disease, using a vetrebrate model system

Grant Number:

1R03DE035681-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2027

Project Abstract

Project Summary Schneckenbecken dysplasia (SBD) is a rare congenital disease characterized by severe skeletal dysplasia, caused by mutations in the nucleotide-sugar transporter gene, SLC35D1. SLC35D1 resides in the endoplasmic reticulum and facilitates transport of UDP-sugars for post-translational ...

Research Terms

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Andrew Santiago-Frangos

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 16/100

Active award

$249,000

FY 2026

Project Title

Mechanisms of CRISPR-mediated immunity and applications beyond editing

Grant Number:

5R00GM147842-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2022

End Date:

1/19/2027

Project Abstract

The discovery of CRISPR (Clustered Regularly Interspaced Short Palindromic Repeats) systems led to creative new applications that are transforming science and medicine. However, the rapid discovery of new CRISPR systems outpaces our understanding of their biological roles in anti-phage defense and t...

Research Terms

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Lisa Soyeon Baik

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Exploratory lead · 16/100

Active award

$238,502

FY 2026

Project Title

Taste perception of host cues in the invasive disease vector mosquito Aedes albopictus

Grant Number:

4R00DC021504-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2028

Project Abstract

PROJECT SUMMARY Aedes albopictus (Ae. albopictus), also known as the Asian tiger mosquito, is a highly invasive and aggressive disease vector that has rapidly invaded every continent on earth except Antarctica. Ae. albopictus spreads diseases including Zika, Chikungunya, yellow fever, and dengue. D...

Research Terms

<A. albopictus><Address><Ae. Albopictus><Aedes albopictus><Affect><Antarctica><Asian><Attention><Behavior><Behavioral><Bite><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Chemicals><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Cues><Culicidae><Dangerousness><Dengue><Detection><Development><Development and Research><Disease><Disease Vectors><Disorder><Earth><Electrophysiology><Electrophysiology (science)><Environment><Funding><Genetic><Gustation><Health><Human><Human Bites><Individual><Invaded><Investigation><Investigators><Machine Learning><Mentors><Methods><Modern Man><Molecular><Molecular Genetics><Mosquito Control><Mosquitoes><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Panthera tigris><Persons><Phase><Physiologic><Physiological><Physiology><Planet Earth><Position><Positioning Attribute><Prevention><R & D><R&D><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Research Personnel><Researchers><Role><Secure><Skin><Surface><System><Taste><Taste Buds><Taste Perception><Techniques><Testing><Tigers><Training><Transgenic Organisms><Universities><Visual><Yellow Fever><ZIKA><base><bases><behavior response><behavioral response><blood meal><career development><chikungunya><climate change><climatic changes><communicable disease transmission><design><designing><developmental><disease transmission><electrophysiological><global climate change><gustatory perception><gustatory processing><gustatory response><gustatory system><improved><infectious disease transmission><interdisciplinary approach><interest><machine based learning><multidisciplinary approach><mutant><neuronal><novel><old age><prevent><preventing><professor><receptor><research and development><response><sensory system><social role><taste processing><taste receptor><taste response><taste stimuli><taste system><tool><transcriptome sequencing><transcriptomic sequencing><transgenic><vector control><vector mosquito><vector-borne pathogen><vectorborne pathogen><virtual>

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Suzhao Li

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 16/100

Active award

$234,000

FY 2026

Project Title

Identify new regulators of outer membrane vesicle entry into macrophages

Grant Number:

5R21AI183060-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/18/2024

End Date:

10/31/2026

Project Abstract

PROJECT SUMMARY Outer membrane vesicles (OMVs) released by extracellular Gram-negative bacteria can deliver lipopolysaccharide (LPS) and other bacterial molecules to the cytosol of macrophages. OMVs enter macrophages through endocytosis and reach the endosome of macrophages. Subsequently, components...

Research Terms

<Apoptosis-Related Cysteine Protease Caspase 1><Assay><Bacteria><Bacterial Infections><Beta Proprotein Interleukin 1><Binding><Bioassay><Biological Assay><CASP-1><CASP1><CASP1 gene><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><Candidate Disease Gene><Candidate Gene><Caspase><Caspase Gene><Caspase-1><Caspase-1 Gene><Cell Body><Cell Communication and Signaling><Cell Death><Cell Signaling><Cell-Death Protease><Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Communicable Diseases><Cysteine Endopeptidases><Cysteine Protease><Cysteine Proteinases><Cytosol><Data><Development><Disease><Disorder><Endocytosis><Endosomes><Endotoxins><Enzyme Precursors><Event><Genes><Genetic Screening><Glean><Goals><Gram-Negative Bacteria><Homolog of Drosophila TOLL><Human><ICE Protease><ICE-like protease><IL-1 beta><IL-1 beta Convertase><IL-1 beta-Converting Enzyme><IL-1 β><IL-1-b><IL-1BC><IL-1b Converting Enzyme><IL-1β><IL1-Beta><IL1-β><IL1B Protein><IL1B-Convertase><IL1BC><IL1BCE><IL1F2><IL1β><Immune><Immunes><Individual><Infectious Diseases><Infectious Disorder><Inflammasome><Inflammation><Inflammatory><Inflammatory Response><Innate Immune Response><Innate Immunity><Interleukin 1-B Converting Enzyme><Interleukin 1-Beta Convertase><Interleukin 1beta><Interleukin-1 Beta Converting Enzyme><Interleukin-1 Converting Enzyme><Interleukin-1 beta><Interleukin-1β><Intracellular Communication and Signaling><Knowledge><Link><Lipopolysaccharides><Macrophage><Measures><Mediating><Mediator><Membrane><Mice><Mice Mammals><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Mφ><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Pathogen detection><Pathogenesis><Pathway interactions><Pattern><Phosphatides><Phospholipids><Preinterleukin 1 Beta><Proenzymes><Receptosomes><Research><Role><Signal Transduction><Signal Transduction Systems><Signaling><Source><Surface><TLR4><TLR4 gene><Toll Homologue><Vesicle><Zymogens><bacteria infection><bacterial disease><biological signal transduction><candidate identification><candidate selection><clustered regularly interspaced short palindromic repeats screen><combat><cystein protease><cystein proteinase><cysteine endopeptidase><cytokine><developmental><endosome membrane><experiment><experimental research><experimental study><experiments><extracellular><genome scale><genome-wide><genomewide><insight><membrane structure><necrocytosis><pathogen><pathway><social role><toll-like receptor 4><vesicle release><vesicular release>

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Lei Stanley Qi

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 16/100

Active award

$231,000

FY 2026

Project Title

An inducible dual up/down gene regulation CRISPR system to study neuronal activity and regeneration

Grant Number:

5R21NS140949-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Project Abstract

ABSTRACT The dynamic processes of axon regeneration and neuronal repair are governed by an intricate network of genetic pathways that involve multiple genes to be activated and repressed, but a full comprehension of how these genes interact remains elusive. While many individual genes that influence...

Research Terms

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Jeffrey Ohmann Bush

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 16/100

Active award

$211,752

FY 2026

Project Title

Developmental and molecular basis for a craniofacial metabolic syndrome

Grant Number:

5R21DE033889-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/3/2025

End Date:

1/31/2027

Project Abstract

Project Summary While causal genetic variants have been identified for many craniofacial syndromes, the functions of these genes in normal development and the mechanisms by which these variants lead to disease often remain unknown. Catel-Manzke syndrome (CMS) is a condition in which patients exhibit...

Research Terms

<3-Pyridinecarboxylic Acid><Ablation><Affect><Alleles><Allelomorphs><Anabolism><Assay><Bilateral><Bioassay><Biological Assay><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cas nuclease technology><Causality><Characteristics><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Craniofacial Abnormalities><D-Glucose><DNA mutation><Data><Dehydratases><Dehydrogenases><Developed Countries><Development><Developmental Process><Dextrose><Diet><Dihydronicotinamide Adenine Dinucleotide><Diphosphopyridine Nucleotide><Disease><Disorder><Drug Therapy><Electroporation><Embryo><Embryonic><Enzyme Gene><Enzymes><Etiology><Exhibits><Extremities><Fingers><Foundations><Gene Expression><Gene variant><Gene x Environment Interaction><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Glucose><Glycosaminoglycans><Goals><GxE interaction><Heart Vascular><Human><Human Genome><Hydrases><Hydro-Lyases><Hydrogenase><Hydrogenlyase><Industrialized Countries><Industrialized Nations><Infant Mortality><Infant Mortality Total><Inferior Maxillary Bone><Intermediary Metabolism><Knowledge><Kynureninase><Kynurenine><Lead><Limb structure><Limbs><Mandible><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolic syndrome><Metabolism><Mice><Mice Mammals><Micrognathism><Missense Mutation><Modeling><Modern Man><Molecular><Molecular Disease><Mucopolysaccharides><Murine><Mus><Mutant Strains Mice><Mutation><Nadide><Neural Crest><Niacin><Nicotinamide adenine dinucleotide><Nicotinamide-Adenine Dinucleotide><Nicotinic Acids><Non-Trunk><Nucleotide Sugars Metabolism><Nucleotide Sugars Metabolism Pathway><Outcome><Oxidoreductase><Oxidoreductase Gene><Pathway interactions><Patients><Pb element><Perinatal><Peripartum><Phalanx><Pharmacological Treatment><Pharmacotherapy><Phenotype><Pierre Robin Syndrome><Pierre Robin sequence><Point Mutation><Preventative strategy><Prevention strategy><Preventive><Preventive strategy><Protein Family><Reductases><Regulation><Reporting><Role><Secondary Palate><Sequence Homology><Series><Skeletal Development><Specificity><Supplementation><Syndrome><Testing><Therapeutic><Tissues><Tongue><Variant><Variation><allelic variant><biosynthesis><causation><cell type><circulatory system><congenital anomaly><craniofacial><craniofacial anomalies><craniofacial complex><craniofacial defects><craniofacial development><craniofacial malformation><craniofacies><death among infants><death in first year of life><death in infancy><death in infants><developed country><developed nation><developed nations><developmental><dietary><diets><disease causation><disease phenotype><dosage><drug intervention><drug treatment><electroporative delivery><environment effect on gene><gene editing method><gene editing methodology><gene editing strategy><gene editing techniques><gene electrotransfer><gene environment interaction><gene function><gene-editing approach><genetic variant><genome mutation><genomic variant><heavy metal Pb><heavy metal lead><high risk><human whole genome><improved><in vivo><indexing><infant death><infant demise><infant morbidity><infantile death><insight><kynurenine hydrolase><loss of function><malformation><mandibular><member><metabolism measurement><metabolomics><metabonomics><micrognathia><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><mortality in infants><mouse genetics><mouse model><mouse mutant><murine model><next generation><novel><pathway><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spatial and temporal><spatial temporal><spatiotemporal><tool><transcriptomics>

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Ophir D Klein

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 16/100

Active award

$211,752

FY 2026

Project Title

Developmental and molecular basis for a craniofacial metabolic syndrome

Grant Number:

5R21DE033889-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/3/2025

End Date:

1/31/2027

Project Abstract

Project Summary While causal genetic variants have been identified for many craniofacial syndromes, the functions of these genes in normal development and the mechanisms by which these variants lead to disease often remain unknown. Catel-Manzke syndrome (CMS) is a condition in which patients exhibit...

Research Terms

<3-Pyridinecarboxylic Acid><Ablation><Affect><Alleles><Allelomorphs><Anabolism><Assay><Bilateral><Bioassay><Biological Assay><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cas nuclease technology><Causality><Characteristics><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Craniofacial Abnormalities><D-Glucose><DNA mutation><Data><Dehydratases><Dehydrogenases><Developed Countries><Development><Developmental Process><Dextrose><Diet><Dihydronicotinamide Adenine Dinucleotide><Diphosphopyridine Nucleotide><Disease><Disorder><Drug Therapy><Electroporation><Embryo><Embryonic><Enzyme Gene><Enzymes><Etiology><Exhibits><Extremities><Fingers><Foundations><Gene Expression><Gene variant><Gene x Environment Interaction><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Glucose><Glycosaminoglycans><Goals><GxE interaction><Heart Vascular><Human><Human Genome><Hydrases><Hydro-Lyases><Hydrogenase><Hydrogenlyase><Industrialized Countries><Industrialized Nations><Infant Mortality><Infant Mortality Total><Inferior Maxillary Bone><Intermediary Metabolism><Knowledge><Kynureninase><Kynurenine><Lead><Limb structure><Limbs><Mandible><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolic syndrome><Metabolism><Mice><Mice Mammals><Micrognathism><Missense Mutation><Modeling><Modern Man><Molecular><Molecular Disease><Mucopolysaccharides><Murine><Mus><Mutant Strains Mice><Mutation><Nadide><Neural Crest><Niacin><Nicotinamide adenine dinucleotide><Nicotinamide-Adenine Dinucleotide><Nicotinic Acids><Non-Trunk><Nucleotide Sugars Metabolism><Nucleotide Sugars Metabolism Pathway><Outcome><Oxidoreductase><Oxidoreductase Gene><Pathway interactions><Patients><Pb element><Perinatal><Peripartum><Phalanx><Pharmacological Treatment><Pharmacotherapy><Phenotype><Pierre Robin Syndrome><Pierre Robin sequence><Point Mutation><Preventative strategy><Prevention strategy><Preventive><Preventive strategy><Protein Family><Reductases><Regulation><Reporting><Role><Secondary Palate><Sequence Homology><Series><Skeletal Development><Specificity><Supplementation><Syndrome><Testing><Therapeutic><Tissues><Tongue><Variant><Variation><allelic variant><biosynthesis><causation><cell type><circulatory system><congenital anomaly><craniofacial><craniofacial anomalies><craniofacial complex><craniofacial defects><craniofacial development><craniofacial malformation><craniofacies><death among infants><death in first year of life><death in infancy><death in infants><developed country><developed nation><developed nations><developmental><dietary><diets><disease causation><disease phenotype><dosage><drug intervention><drug treatment><electroporative delivery><environment effect on gene><gene editing method><gene editing methodology><gene editing strategy><gene editing techniques><gene electrotransfer><gene environment interaction><gene function><gene-editing approach><genetic variant><genome mutation><genomic variant><heavy metal Pb><heavy metal lead><high risk><human whole genome><improved><in vivo><indexing><infant death><infant demise><infant morbidity><infantile death><insight><kynurenine hydrolase><loss of function><malformation><mandibular><member><metabolism measurement><metabolomics><metabonomics><micrognathia><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><mortality in infants><mouse genetics><mouse model><mouse mutant><murine model><next generation><novel><pathway><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spatial and temporal><spatial temporal><spatiotemporal><tool><transcriptomics>

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Jeffrey R Johnson

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Exploratory lead · 16/100

Active award

$211,250

FY 2026

Project Title

CRISPR-Cas9 base editing approaches to discover ubiquitination events promoting flavivirus infection

Grant Number:

5R21AI187731-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/14/2024

End Date:

10/31/2026

Project Abstract

PROJECT SUMMARY Viruses extensively remodel the cells that they infect. Ubiquitination networks are frequent targets of viral manipulation, but compared to other modifications such as phosphorylation, our general understanding of functional ubiquitination events is limited. In this project, we will ...

Research Terms

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Guang Yang

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 16/100

Active award

$205,625

FY 2026

Project Title

Targeting the Mesocortical Glutamatergic Pathway for Chronic Pain Treatment

Grant Number:

5R21NS137066-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

Project Summary The malfunction of the mesocortical pathway, connecting the ventral tegmental area (VTA) to the prefrontal cortex (PFC), has been associated with nerve injury-induced neuropathic pain. While extensive research has focused on dopamine transmission in reward and aversion within this pa...

Research Terms

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Lamba Omar Sangare

TEXAS A&M UNIVERSITY, COLLEGE STATION, TX

Exploratory lead · 16/100

Active award

$189,486

FY 2026

Project Title

Determining the mechanisms of Toxoplasma gondii colonization and crossing of the placental barrier

Grant Number:

5R21AI185518-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY Our understanding of Toxoplasma gondii (T. gondii) and other pathogens transmitted from mother to fetus is limited. However, they significantly contribute to fetal illness and death worldwide. This proposal aims to address this knowledge gap by identifying and characterizing T. gondi...

Research Terms

<0-11 years old><Address><Adhesion Molecule><Adhesions><Affect><Animal Model><Animal Models and Related Studies><Brain><Brain Nervous System><CD54 Antigens><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cavia><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Body><Cell Surface Antigens><Cell fusion><Cell membrane><Cells><Cells Placenta-Tissue><Cessation of life><Child><Child Youth><Children (0-21)><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Congenital Toxoplasma Infections><Congenital Toxoplasma gondii Infection><Congenital Toxoplasmosis><Cytoplasmic Membrane><Data><Death><Defect><Development><ERK MAP Kinases><Encephalon><Environment><Epithelium><Extracellular Signal Regulated Kinases><Extracellular Signal-Regulated MAP Kinases><Fetus><Foundations><Future><GPI Membrane Anchors><GeneHomolog><Genes><Genetic><Glycoinositol Phospholipid Membrane Anchor><Glycosyl-Phosphatidylinositol Membrane Protein Anchors><Glycosylphosphatidylinositol Anchors><Goals><Guide RNA><Guinea Pigs><Guinea Pigs Mammals><High Throughput Assay><Homolog><Homologous Gene><Homologue><Human><ICAM-1><Immunological Surface Markers><In Vitro><Incidence><Infection><Ingestion><Integral Membrane Protein><Intercellular adhesion molecule 1><Intrinsic Membrane Protein><Investigators><Knock-out><Knockout><Knowledge><Libraries><MAPK ERK Kinases><Macrophage><Mediating><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Methods><Modern Man><Mothers><Mφ><Normal Placentoma><Parasites><Phosphorylation><Placenta><Placenta Embryonic Tissue><Placentome><Plasma Membrane><Pregnancy Complications><Process><Progenitor Cells><Protein Phosphorylation><Proteins><Recombinant Proteins><Recombinants><Research><Research Personnel><Researchers><Resistance><Role><Side><Structure><Surface><Surface Antigens><Surface Proteins><System><T gondii><T. gondii><Testing><Threonine/Tyrosine Protein Kinase><Time><Toxoplasma gondii><Transmembrane Protein><Transmembrane Protein Gene><Transmission><Upregulation><Vertical Transmission><Work><cell adhesion protein><complications during pregnancy><congenital infection><cytokine><design><designing><develop therapy><developmental><extracellular><extracellular signal related kinase><fetal><fetal infection><gRNA><guinea pig model><high throughput screening><in utero><in vivo><ingest><innovate><innovation><innovative><insight><intervention development><intestinal epithelium><kids><loss of function><malformation><migration><model of animal><mouse model><murine model><mutant><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathogen><plasmalemma><pregnancy-related complications><pregnant><prevent><preventing><resistant><secretory protein><social role><stem cells><therapy development><tool><transmission process><treatment development><trophoblast><trophoblast progenitor><trophoblast progenitor cell><trophoblast stem cell><youngster>

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Erin Hisey

VA BOSTON HEALTH CARE SYSTEM, BOSTON, MA

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Effects of cumulative trauma on hippocampal activity and gene function

Grant Number:

1IK2BX006528-01A2

Activity Code:

IK2

Mechanism:

Other

Agency:

VA

Start Date:

10/1/2025

End Date:

9/30/2030

Project Abstract

Accumulation of trauma throughout the lifespan is more strongly associated with the development of threat-related disorders and suicidality than exposure to a single trauma. As a large proportion of veterans are exposed to abuse and neglect in childhood in addition to deployment-related trauma in ad...

Research Terms

<21+ years old><Adaptive Behaviors><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Allopregnanolone><Ammon Horn><Animals><Armed Forces Personnel><Behavior><Behavioral><Biological Markers><Brain><Brain Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Calcium><Candidate Disease Gene><Candidate Gene><Cas nuclease technology><Cell Body><Cells><Child Abuse><Childhood><Childhood Abuse><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cornu Ammonis><Coupled><Data><Development><Diagnosis><Disease><Disorder><Drug Targeting><Early Trauma><Early-life trauma><Electrophysiology><Electrophysiology (science)><Emotional><Encephalon><Exposure to><FDA approved><Fear><Fright><Future><GABA Receptor><Gene Down-Regulation><Gene Expression><Genes><Genetic><Glutamates><Hippocampus><Hyperactivity><Image><In vivo two-photon calcium imaging><Infusion><Infusion procedures><Investigators><L-Glutamate><Life><Mice><Mice Mammals><Military><Military Personnel><Modeling><Molecular><Murine><Mus><Neurophysiology / Electrophysiology><Normal Cell><PTSD><Population><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Predisposition><Prefrontal Cortex><Prevalence><Process><Regulation><Research Personnel><Researchers><Role><Severities><Shapes><Single-Nucleus Sequencing><Social Interaction><Stimulus><Stress><Susceptibility><Symptoms><Techniques><Testing><Time><Training><Transcription Repression><Trauma><Upregulation><Veterans><abuse neglect><adaptation behavior><adaptive behavior><adulthood><alleviate symptom><ameliorating symptom><behavior response><behavioral response><bio-markers><biologic marker><biomarker><career><decrease symptom><design><designing><developmental><drug candidate><effective therapy><effective treatment><electrophysiological><excitatory neuron><experience><experiment><experimental research><experimental study><experiments><fewer symptoms><gamma-Aminobutyric Acid Receptors><gene function><gene manipulation><gene repression><genetic manipulation><genetically manipulate><genetically perturb><glutamatergic><hippocampal><imaging><in vivo><in vivo calcium imaging><infusions><juvenile><juvenile human><life span><lifespan><maladaptive behavior><military member><military population><mouse model><murine model><neglect and abuse><neural><neural circuit><neural circuitry><neural imaging><neuro-imaging><neuroactive steroids><neurocircuitry><neuroimaging><neurological imaging><neuronal excitability><neurosteroids><novel><pediatric><physical model><post-trauma stress disorder><post-traumatic stress symptoms><post-traumatic symptoms><posttrauma stress disorder><posttraumatic stress symptoms><posttraumatic symptoms><psychiatric symptom><reduce symptoms><relieves symptoms><response><restoration><sNuc-Seq><service member><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social><social role><suicidal><suicidality><symptom alleviation><symptom reduction><symptom relief><synaptic circuit><synaptic circuitry><tool><trait><traumatic neurosis>

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VERONICA SHUBAYEV

VA SAN DIEGO HEALTHCARE SYSTEM, SAN DIEGO, CA

Exploratory lead · 10/100

Active award

$0

FY 2026

Project Title

Pathogenesis of Nerve Injury: Role of Tissue Inhibitor of Metalloproteinases-1

Grant Number:

5I01BX000638-14

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2009

End Date:

9/30/2028

Project Abstract

Extremity (e.g., leg) trauma accounts for the majority of combat wounds and causes peripheral nerve injury. Despite the high regenerative capacity of the peripheral nervous system (PNS), patients develop severe sensorimotor abnormalities and neuropathic pain (NP) sustaining for years after injury. I...

Research Terms

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TOHRU FUKAI

CHARLIE NORWOOD VA MEDICAL CENTER, AUGUSTA, GA

Exploratory lead · 10/100

Active award

$0

FY 2026

Project Title

Cu importer CTR1 Cys189 oxidation in atherosclerosis

Grant Number:

5I01BX001232-16

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2011

End Date:

9/30/2028

Project Abstract

The aim of this grant is to elucidate the novel role of endothelial Cu importer CTR1 Cys189 oxidation to protect against Cu-dependent senescence and cuproptosis involved in inflammatory vascular disease. Oxidative stress, inflammation, mitochondrial (mito) ROS/dysfunction in endothelial cells (ECs) ...

Research Terms

<(TNF)-α><22kD Caveolae Protein><APOE><ASCVD><ATAC sequencing><ATAC-seq><ATACseq><Acceleration><Anaplastic T-Lymphocyte with Horseshoe-Shaped Nucleus><Anaplastic T-Lymphocyte with Kidney-Shaped Nucleus><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Aorta><Apo-E><ApoE protein><Apolipoprotein E><Apoptosis><Apoptosis Pathway><Arterial Fatty Streak><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Atherogenicity><Atheroma><Atheromatous><Atheromatous degeneration><Atheromatous plaque><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Basal Transcription Factor><Basal transcription factor genes><Binding><Bioassay><Bioavailability><Biological Assay><Biological Availability><Biosensor><Biotin><Biotinylation><Blood Vessels><C-terminal><CDK4I><CDKN2><CDKN2 Genes><CDKN2A><CDKN2A gene><CMM2><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cachectin><Carrier Proteins><Cas nuclease technology><Caveolae><Caveolas><Caveolin 1, Caveolae Protein, 22kD><Caveolin Proteins><Caveolins><Cell Communication and Signaling><Cell Death><Cell Membrane Lipid Rafts><Cell Senescence Induction><Cell Signaling><Cell surface><Chaperone><Chelating Agents><Chelators><Chronic><Citric Acid Cycle><Closure by Ligation><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complexons><Copper><Cu element><Cyclin-Dependent Kinase Inhibitor 2A Gene><Cysteine><Cytosol><Data><Diet><Disease><Disorder><Dysfunction><Endocytosis><Endothelial Cells><Endothelium><Exhibits><FLK1><Fluorescence><Fluorescence Light Microscopy><Fluorescence Microscopy><Functional disorder><Gene Transfer><General Transcription Factor Gene><General Transcription Factors><Genes><Grant><Growth Agents><Growth Factor><Growth Substances><H2O2><Half-Cystine><Hallmark Cell><High Fat Diet><Human><Hydrogen Peroxide><Hydroperoxide><ICP-MS><INK4><INK4A><Immunofluorescence><Immunofluorescence Immunologic><Inductively Coupled Plasma Mass Spectrometry><Inflammation><Inflammatory><Intracellular Communication and Signaling><KDR gene><Knock-in><Krebs Cycle><L-Cysteine><Label><Ligation><MTS1><MTS1 Genes><Macrophage-Derived TNF><Measures><Mediating><Membrane Microdomains><Mice><Mice Mammals><Micronutrients><Mitochondria><Modeling><Modern Man><Molecular Chaperones><Molecular Interaction><Monocyte-Derived TNF><Murine><Mus><Nuclear><Oxidation-Reduction><Oxidative Stress><Oxygen Consumption><Phenotype><Physiologic Availability><Physiopathology><Play><Programmed Cell Death><Proteins><Proteins Growth Factors><RNA Seq><RNA sequencing><RNAseq><Redox><Reporting><Roentgen Rays><Role><Short interfering RNA><Signal Transduction><Signal Transduction Systems><Signaling><Source><Sphingolipid Microdomains><Sphingolipid-Cholesterol Rafts><Staining method><Stains><TCA cycle><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><TP16><TSG9A><Testing><Therapeutic><Toxic effect><Toxicities><Transcription Factor Proto-Oncogene><Transcription factor genes><Transfection><Transmission Electron Microscopy><Transport Protein Gene><Transport Proteins><Transporter Protein><Tricarboxylic Acid Cycle><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><VEGF><VEGF Receptors><VEGFR><VEGFR-2><VEGFR2><VEGFs><VIP21><VIP21 protein><VPF Receptor><Vascular Diseases><Vascular Disorder><Vascular Endothelial Cell Growth Factor Receptor><Vascular Endothelial Growth Factor Receptor 2><Vascular Endothelial Growth Factors><Vascular Permeability Factor Receptor><Vasodilatation><Vasodilation><Vasorelaxation><Vitamin H><X-Radiation><X-Ray Radiation><X-ray><Xray><angiogenesis><antioxidant therapy><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><atheromatosis><atherosclerosis plaque><atherosclerotic disease><atherosclerotic lesions><atherosclerotic plaque><atherosclerotic vascular disease><biological sensor><biological signal transduction><blood vessel disorder><caveolin 1><cellular aging induction><cellular senescence induction><coenzyme R><cytokine><diets><in vivo><innovate><innovation><innovative><insight><knockin><lipid raft><military veteran><mitochondrial><mitochondrial dysfunction><mortality><mutant><nano particle><nano-sized particle><nanoparticle><nanosized particle><necrocytosis><novel><oxidation><oxidation reduction reaction><p14ARF><p16 Genes><p16INK4 Genes><p16INK4A Genes><p16INK4a><pathophysiology><plaques in atherosclerosis><prevent><preventing><protein biomarkers><protein markers><response><scATAC sequencing><scATAC-seq><scRNA sequencing><scRNA-seq><senescence><senescence induction><senescent><senescent cell><shRNA><short hairpin RNA><siRNA><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell sequencing assay for transposase accessible chromatin><single cell transcriptomic profiling><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell RNA sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><social role><therapeutic target><transcription factor><transcriptome sequencing><transcriptomic sequencing><uptake><vascular><vascular dysfunction><vasculopathy><vesicular integral membrane protein 21 kDa><veteran population>

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Sarah Anne Tishkoff

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Project Abstract

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