Oscar L. Lopez

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

High-opportunity lead · 88/100

Likely hiring

Large award

Very recent

Active award

$4,514,197

FY 2026

Project Title

Alzheimer Disease Research Center

Grant Number:

5P30AG066468-07

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

5/15/2020

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Revised Overall Abstract: The University of Pittsburgh Alzheimer’s Disease Research Center (PITT-ADRC) has shown a clear scientific evolution over the past four decades. Since our inception, we have advanced the areas of ADRD neuropsychiatry, genetics, natural history of AD, validation of clinical c...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD pathology><AD related dementia><AD therapy><AD treatment><ADRD><Achievement><Achievement Attainment><Adult><Adult Human><Advocacy><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease pathology><Alzheimer's disease related dementia><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's therapy><Alzheimers Dementia><Amentia><Area><Awareness><Basic Research><Basic Science><Behavioral Symptoms><Biological><Biological Markers><Biology><Brain><Brain Nervous System><Care Givers><Caregivers><Caring><Causality><Clinical><Clinical Course of Disease><Clinical Data><Clinical Research><Clinical Study><Clinical assessments><Cognition><Cognition Disorders><Cognitive Disturbance><Cognitive Impairment><Cognitive Manifestations><Cognitive Symptoms><Cognitive decline><Cognitive function abnormal><Collaborations><Communication><Communities><Complex><Curriculum><Data><Data Bases><Data Collection><Data Management and Analysis Core><Data Management and Statistical Analysis Core><Data Management and Statistical Core><Databases><Dedications><Dementia><Development><Discipline><Disease><Disorder><Disturbance in cognition><Dysfunction><Early Diagnosis><Early treatment><Education><Education and Training><Educational Curriculum><Educational aspects><Encephalon><Environment><Environmental Factor><Environmental Risk Factor><Etiology><Evaluation><Event><Evolution><Exclusion><Faculty><Family><Foundations><Functional disorder><Genetic><Genetic predisposing factor><Goals><Grant><Health Care Professional><Health Professional><Human Resources><Imaging technology><Impaired cognition><Individual><Infrastructure><Institution><Interdisciplinary Research><Interdisciplinary Study><International><Investigators><Investments><Leadership><Liquid substance><Manpower><Mentors><Methodology><Methods><Modernization><Motivation><Multidisciplinary Collaboration><Multidisciplinary Research><Natural History><Neighborhoods><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Ohio><Outcome><Participant><Pathogenesis><Pathologic><Pathologic Processes><Pathological Processes><Patient Care><Patient Care Delivery><Patients><Pennsylvania><Physiopathology><Preventative therapy><Preventive therapy><Primary Senile Degenerative Dementia><Productivity><Protocol><Protocols documentation><Psychoses><Public Health><Qualifying><Research><Research Personnel><Research Resources><Researchers><Resources><Risk><Risk Factors><Role><Sampling><Scientist><Standardization><Students><Symptoms><Technology><Testing><Training><Training Programs><Training and Education><Universities><West Virginia><Work><adulthood><analytical tool><bio-markers><biologic><biologic marker><biomarker><biomarker development><care for patients><care of patients><career><caring for patients><causation><clinical validation><cognitive assessment><cognitive disease><cognitive disorder><cognitive dysfunction><cognitive loss><cognitive syndrome><cognitive testing><cohort><community factor><community-level factor><convict><data base><data sharing><data tools><developmental><disease causation><disease phenotype><early detection><early therapy><education research><environmental risk><fluid><genetic risk factor><health and care delivery><health care delivery><health delivery systems><health services delivery><imaging biomarker><imaging marker><imaging-based biological marker><imaging-based biomarker><imaging-based marker><improved><inherited factor><innovate><innovation><innovative><insight><interdisciplinary approach><international center><lesson plans><liquid><member><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><multidisciplinary><multidisciplinary approach><neural imaging><neuro-imaging><neurogenetics><neuroimaging><neurological imaging><neuronal><neuropathologic><neuropathological><neuropathology><neuropsychiatric><neuropsychiatry><novel><outreach><outreach program><pathophysiology><personnel><primary degenerative dementia><programs><recruit><resilience><resilient><rural area><rural location><rural region><senile dementia of the Alzheimer type><social role><suburb><suburban><suburbia>

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DAVID M. HOLTZMAN

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 88/100

Likely hiring

Large award

Very recent

Active award

$4,453,224

FY 2026

Project Title

Alzheimer's Disease Research Center

Grant Number:

5P30AG066444-07

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

5/15/2020

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Overall: Project Summary – 2P30AG066444-06 The Washington University Charles F. and Joanne Knight Alzheimer Disease Research Center (Knight ADRC) initiates, fosters, and supports the performance of innovative, cutting-edge research on Alzheimer disease (AD) and related dementias (ADRD) with regard t...

Research Terms

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Carlos Cruchaga

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 80/100

Likely hiring

Large award

Recent

Active award

$3,086,339

FY 2026

Project Title

CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"

Grant Number:

1U01AG084514-01A1

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Genetic studies in the context of Alzheimer Disease (AD) are significantly biased by information coming from the same homogeneous population: Non-Hispanics Whites (NHW). The ADSP Follow-Up Study (FUS) long term goals include to fully reveal the genetic architecture of AD in multiple ethnic groups an...

Research Terms

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Jorge Jesus Llibre-Guerra

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 80/100

Likely hiring

Large award

Recent

Active award

$3,086,339

FY 2026

Project Title

CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"

Grant Number:

1U01AG084514-01A1

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Genetic studies in the context of Alzheimer Disease (AD) are significantly biased by information coming from the same homogeneous population: Non-Hispanics Whites (NHW). The ADSP Follow-Up Study (FUS) long term goals include to fully reveal the genetic architecture of AD in multiple ethnic groups an...

Research Terms

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Michael Jay Corley

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 80/100

Likely hiring

Large award

Very recent

Active award

$1,191,371

FY 2026

Project Title

Social epigenetics of Alzheimer's disease and related dementias in Latin American countries

Grant Number:

5R01AG082056-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY (ABSTRACT) Alzheimer’s disease (AD) and related dementias like frontotemporal dementia (FTD) disproportionately affect Latinos and socioeconomically disadvantaged groups. Nevertheless, the bulk of the research exploring the multifaceted biology of dementia, which includes both geneti...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD and related dementia><AD dementia><AD related dementia><AD3-like protein><AD3LP><ADRD><APOE><Aberrant DNA Methylation><Address><Affect><Aged 65 and Over><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><Apo-E><ApoE protein><Apolipoprotein E><Area><Argentina><Atlases><Autopsy><BDNF><Biological><Biological Aging><Biological Markers><Biology><Blood><Blood Reticuloendothelial System><Body Tissues><Brain><Brain Nervous System><Brain-Derived Neurotrophic Factor><Candidate Disease Gene><Candidate Gene><Caucasian><Caucasian Race><Caucasians><Caucasoid><Caucasoid Race><Cell Body><Cells><Chile><Clinical><Cognitive><Cohort Studies><Collection><Colombia><Country><DNA Methylation><DNA methylation profiling><Data><Data Set><Dementia><Diagnosis><Disease><Disorder><Disparities><Disparity><Economic Income><Economical Income><Economically Deprived Population><Encephalon><Environment><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Ethnic Origin><Ethnicity><European><Exhibits><FTD dementia><Frontal Temporal Dementia><Frontotemporal Dementia><Funding><Generations><Genes><Genetic><Genome><Genomics><GrimAge clock><Hannum clock><Health Inequity><Health Status><Heterogeneity><Hispanic><Horvath clock><Human><Immune><Immunes><Income><Individual><Inequalities in Health><Inequality><Inequities in Health><Inflammation><Inflammatory><Intervention Strategies><Knowledge><LMIC><Latin America><Latin American><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Level of Health><Link><Lobe><MT-bound tau><Measures><Mediating><Methyl-Seq><MethylSeq><Methylation sequencing><Modern Man><Modification><Molecular><NIH><National Institutes of Health><Neuropsychologies><Neuropsychology><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Occidental><Outcome><PSEN1><PSEN2><Participant><Persons><PhenoAge clocks><Phenotype><Play><Population><Prevalence><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Race><Races><Regulatory Regions><Research><Rest><Risk><Role><S182 protein><Sampling><Socio-economic status><Socioeconomic Status><Socioeconomically disadvantaged><Standardization><Stress><Study of Latinos><Testing><Tissues><Underrepresented Groups><Underrepresented Populations><United States National Institutes of Health><Validation><above age 65><accelerated aging><accelerated biological age><accelerated biological aging><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age acceleration><age associated dementia><age induced dementia><age of 65 years onward><age related dementia><aged 65 and greater><aged 65+><aged brain><aged ≥65><aging associated dementia><aging brain><aging related dementia><bio-markers><biologic><biologic marker><biological process of age><biomarker><brain health><brain tissue><cardiometabolic><cardiometabolism><cohort><cohort research study><cohort survey><death risk><dementia risk><disparity in health><economically deprived group><economically deprived people><economically disadvantaged group><economically disadvantaged individual><economically disadvantaged people><economically disadvantaged population><environmental risk><epigenetic age clocks><epigenetic biomarker><epigenetic clock><epigenetic marker><epigenetic molecular clocks><epigenetically><epigenomics><ethnic identity><front temporal dementia><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><gene regulatory network><genetic regulatory element><genome scale><genome-wide><genomewide><health data><health disparity><health inequalities><health level><human old age (65+)><incomes><lens><lenses><lobes><low and middle-income countries><low income country><methylation biomarker><methylation clock><methylation marker><methylation pattern><microtubule bound tau><microtubule-bound tau><mortality risk><necropsy><neural correlate><neural imaging><neuro-imaging><neuroimaging><neurological imaging><neuropsychologic><new approaches><novel approaches><novel strategies><novel strategy><over 65 years><postmortem><presenilin 1 protein><presenilin 2 protein><presenilin-1><presenilin-2><primary degenerative dementia><racial><racial background><racial origin><recruit><risk factor for dementia><risk for dementia><senile dementia of the Alzheimer type><social><social adversity><social disadvantage><social disparities><social health determinants><social inequality><social role><socio-economic disadvantage><socio-economic position><socio-economically disadvantaged><socio-economically underprivileged><socioeconomic disadvantage><socioeconomic position><socioeconomically underprivileged><tau><tau Proteins><tau factor><under representation of groups><under represented groups><under represented people><under represented populations><underclass><underrepresentation of groups><underrepresented people><validations><white race><τ Proteins><≥65 years>

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CHRISTIAN J PIKE

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

High-opportunity lead · 80/100

Likely hiring

Large award

Very recent

Active award

$1,041,827

FY 2026

Project Title

Dietary protection against APOE4 phenotypes in aging and Alzheimer's

Grant Number:

5R01AG084485-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The ɛ4 allele of apolipoprotein E (APOE4) is associated with accelerated aging and mortality as well increased vulnerability to Alzheimer’s disease (AD). Although the causal links between APOE4, aging, and AD risk remain to be fully defined, candidate mechanisms include regulation of energy metaboli...

Research Terms

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Rachel Frances Buckley

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$982,110

FY 2026

Project Title

Building predictive algorithms to identify resilience and resistance to Alzheimer's disease

Grant Number:

5R01AG079142-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY There are two observed phenomena that defy the traditional Alzheimer’s disease (AD) trajectory; those who resist the accumulation of AD pathology (amyloid and/or tau) despite evidence of risk factors, and those who present with AD pathology but remain resilient to cognitive decline. ...

Research Terms

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Michael C Donohue

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$982,110

FY 2026

Project Title

Building predictive algorithms to identify resilience and resistance to Alzheimer's disease

Grant Number:

5R01AG079142-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY There are two observed phenomena that defy the traditional Alzheimer’s disease (AD) trajectory; those who resist the accumulation of AD pathology (amyloid and/or tau) despite evidence of risk factors, and those who present with AD pathology but remain resilient to cognitive decline. ...

Research Terms

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Timothy J Hohman

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$982,110

FY 2026

Project Title

Building predictive algorithms to identify resilience and resistance to Alzheimer's disease

Grant Number:

5R01AG079142-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY There are two observed phenomena that defy the traditional Alzheimer’s disease (AD) trajectory; those who resist the accumulation of AD pathology (amyloid and/or tau) despite evidence of risk factors, and those who present with AD pathology but remain resilient to cognitive decline. ...

Research Terms

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KARIN M REINISCH

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$837,500

FY 2026

Project Title

Mechanisms in Membrane Dynamics

Grant Number:

5R35GM131715-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2019

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract: A defining feature of cells are membrane bilayers that separate them from their environment and, in eukaryotic cells, delineate intracellular organelles with specialized functions. For cells to live and replicate, they must be able to maintain and expand these membranes. In eukaryotes, the...

Research Terms

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Chongzhao Ran

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$825,292

FY 2026

Project Title

Molecular Chemiluminescence Probes for Imaging of Amyloid beta in Animal Models

Grant Number:

5R01AG083759-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The highly exciting results from the recent clinical trial of Lecanemab for Alzheimer’s disease (AD) reignite tremendous enthusiasm for AD drug development. Lecanemab is the first drug to meet all the clinical endpoints without controversy over the past decades. However, compared to other diseases l...

Research Terms

<2-photon><3-D><3-Dimensional><3D><AD dementia><AD model><AD therapy><AD transgenic mice><AD treatment><Acceleration><Active Oxygen><Address><Advanced Development><Age><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease therapeutic><Alzheimer's disease therapy><Alzheimer's disease transgenic mice><Alzheimer's therapeutic><Alzheimer's therapy><Alzheimer's transgenic mice><Alzheimers Dementia><Amaze><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Anti-Cancer Agents><Antibodies><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Aβ><Body Tissues><Brain><Brain Nervous System><Brain imaging><Cancer Drug><Cancers><Cell Communication and Signaling><Cell Signaling><Clinical><Clinical Trials><Data><Dependence><Deposit><Deposition><Disease><Disorder><Drug Evaluation><Drug Evaluation Studies><Drug usage><Drugs><Dwarfism><Effectiveness><Encephalon><Exhibits><Fees><Fluorescence><Future><Goals><Image><In Vitro><Inflammation><Injectable><Intracellular Communication and Signaling><Label><Language><Malignant Neoplasms><Malignant Tumor><Medication><Mice><Mice Mammals><Molecular><Monitor><Murine><Mus><Nanism><Neoplastic Disease Chemotherapeutic Agents><Noise><Optics><Oxygen Radicals><PET><PET Scan><PET imaging><PETSCAN><PETT><Penetration><Pharmaceutical Preparations><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Pro-Oxidants><Process><Property><Rad.-PET><Reactive Oxygen Species><Reporting><Research><Rotation><Signal Transduction><Signal Transduction Systems><Signaling><System><Therapeutic Effect><Therapeutic Intervention><Therapeutic Studies><Therapy Research><Tissues><Transgenic Organisms><Tumor-Specific Treatment Agents><Validation><Wild Type Mouse><a beta peptide><abeta><ages><alzheimer model><amyloid beta><amyloid-b protein><anti-cancer drug><anti-cancer research><beta amyloid fibril><biological signal transduction><bioluminescence imaging><bioluminescent imaging><brain visualization><cancer research><cost effective><cost effectiveness><design><design validation><design verification><designing><determine efficacy><drug development><drug discovery><drug use><drug/agent><dwarf><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><enzyme activity><evaluate efficacy><examine efficacy><fluorescence imaging><fluorescent imaging><histologic image><histological image><image-based method><imaging><imaging in vivo><imaging method><imaging modality><imaging probe><improved><in vivo><in vivo imaging><in vivo two-photon imaging><intervention therapy><malignancy><model of animal><mouse model><murine model><neoplasm/cancer><novel><optic imaging><optical><optical imaging><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><pre-clinical imaging><preclinical><preclinical imaging><primary degenerative dementia><response to therapy><response to treatment><senile dementia of the Alzheimer type><soluble amyloid precursor protein><therapeutic response><therapy response><three dimensional><tool><transgenic><treatment response><treatment responsiveness><two-photon><validations><water solubility><wildtype mouse>

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Can Martin Zhang

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$825,292

FY 2026

Project Title

Molecular Chemiluminescence Probes for Imaging of Amyloid beta in Animal Models

Grant Number:

5R01AG083759-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The highly exciting results from the recent clinical trial of Lecanemab for Alzheimer’s disease (AD) reignite tremendous enthusiasm for AD drug development. Lecanemab is the first drug to meet all the clinical endpoints without controversy over the past decades. However, compared to other diseases l...

Research Terms

<2-photon><3-D><3-Dimensional><3D><AD dementia><AD model><AD therapy><AD transgenic mice><AD treatment><Acceleration><Active Oxygen><Address><Advanced Development><Age><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease therapeutic><Alzheimer's disease therapy><Alzheimer's disease transgenic mice><Alzheimer's therapeutic><Alzheimer's therapy><Alzheimer's transgenic mice><Alzheimers Dementia><Amaze><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Anti-Cancer Agents><Antibodies><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Aβ><Body Tissues><Brain><Brain Nervous System><Brain imaging><Cancer Drug><Cancers><Cell Communication and Signaling><Cell Signaling><Clinical><Clinical Trials><Data><Dependence><Deposit><Deposition><Disease><Disorder><Drug Evaluation><Drug Evaluation Studies><Drug usage><Drugs><Dwarfism><Effectiveness><Encephalon><Exhibits><Fees><Fluorescence><Future><Goals><Image><In Vitro><Inflammation><Injectable><Intracellular Communication and Signaling><Label><Language><Malignant Neoplasms><Malignant Tumor><Medication><Mice><Mice Mammals><Molecular><Monitor><Murine><Mus><Nanism><Neoplastic Disease Chemotherapeutic Agents><Noise><Optics><Oxygen Radicals><PET><PET Scan><PET imaging><PETSCAN><PETT><Penetration><Pharmaceutical Preparations><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Pro-Oxidants><Process><Property><Rad.-PET><Reactive Oxygen Species><Reporting><Research><Rotation><Signal Transduction><Signal Transduction Systems><Signaling><System><Therapeutic Effect><Therapeutic Intervention><Therapeutic Studies><Therapy Research><Tissues><Transgenic Organisms><Tumor-Specific Treatment Agents><Validation><Wild Type Mouse><a beta peptide><abeta><ages><alzheimer model><amyloid beta><amyloid-b protein><anti-cancer drug><anti-cancer research><beta amyloid fibril><biological signal transduction><bioluminescence imaging><bioluminescent imaging><brain visualization><cancer research><cost effective><cost effectiveness><design><design validation><design verification><designing><determine efficacy><drug development><drug discovery><drug use><drug/agent><dwarf><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><enzyme activity><evaluate efficacy><examine efficacy><fluorescence imaging><fluorescent imaging><histologic image><histological image><image-based method><imaging><imaging in vivo><imaging method><imaging modality><imaging probe><improved><in vivo><in vivo imaging><in vivo two-photon imaging><intervention therapy><malignancy><model of animal><mouse model><murine model><neoplasm/cancer><novel><optic imaging><optical><optical imaging><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><pre-clinical imaging><preclinical><preclinical imaging><primary degenerative dementia><response to therapy><response to treatment><senile dementia of the Alzheimer type><soluble amyloid precursor protein><therapeutic response><therapy response><three dimensional><tool><transgenic><treatment response><treatment responsiveness><two-photon><validations><water solubility><wildtype mouse>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Feixiong Cheng

CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$794,088

FY 2026

Project Title

TREM2 Genotype-Informed Drug Repurposing and Combination Therapy Design for Alzheimers Disease

Grant Number:

5R01AG076448-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The cumulative evidence indicates neuro-inflammation play crucial roles in Alzheimer’s disease (AD) and anti- inflammatory agents (i.e., microglia-targeted therapies) show potential treatments for AD. The treatment window for microglia-targeted therapies may at least be open later in...

Research Terms

<3-D><3-Dimensional><3D><AD dementia><AD pathology><AD patients><AD risk><AD risk factor><AD therapy><AD treatment><AKT inhibition><APOE><Affect><African American><Afro American><Afroamerican><Age><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease risk><Alzheimer's disease therapeutic><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's patient><Alzheimer's therapeutic><Alzheimer's therapy><Alzheimers Dementia><American><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Apo-E><ApoE protein><Apolipoprotein E><Area><Asthma><Attention><Aβ><Biology><Brain><Brain Nervous System><Bronchial Asthma><Cell Body><Cell Communication and Signaling><Cell Line><Cell Nucleus><Cell Signaling><CellLine><Cells><Cerebrum><Clinic><Clinical Trials><Combination Drug Therapy><Combined Modality Therapy><Communication><Computers><DNA mutation><Data><Data Bases><Databases><Degenerative Neurologic Disorders><Development><Disease><Disease Outcome><Disease Progression><Disease associated microglia><Disorder><Dose><Drug Combinations><Drug Screening><Drug Targeting><Drug Therapy><Drug usage><Drugs><Electronic Health Record><Encephalon><Gene Targeting><Gene Transcription><Generations><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genomics><Genotype><Glia><Glial Cells><Health system><Hortega cell><Human><Human Genetics><Immune><Immunes><Incidence><Inflammation><Inflammatory><Intracellular Communication and Signaling><Investigation><KI mice><Knock-in Mouse><Knowledge Portal><Knowledge base Portal><Knowledgebase Portal><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Link><MT-bound tau><Machine Learning><Medication><Medicine><Methodology><Methods><Mice><Mice Mammals><Microglia><Modern Man><Molecular><Molecular Target><Multimodal Therapy><Multimodal Treatment><Murine><Mus><Mutation><Nature><Nerve Degeneration><Nervous System Degenerative Diseases><Network-based><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroglia><Neuroglial Cells><Neurologic Degenerative Conditions><Neuron Degeneration><New York City><Non-neuronal cell><Nonneuronal cell><Nucleus><Observational Study><Organoids><Pathogenesis><Patients><Penetration><Persons><Pharmaceutical Epidemiology><Pharmaceutical Preparations><Pharmacoepidemiology><Pharmacological Treatment><Pharmacotherapy><Play><Polychemotherapy><Population><Primary Senile Degenerative Dementia><Process><Property><RNA Expression><Research><Risk><Risk-associated variant><Role><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Source><Strains Cell Lines><System><Systems Biology><TREM2><TREM2 gene><Tauopathies><Testing><Toxic effect><Toxicities><Transcription><Triggering Receptor Expressed in Myeloid Cells 2><Triggering Receptor Expressed on Myeloid Cells 2><United States><Validation><Variant><Variation><a beta peptide><abeta><ages><alzheimer risk><amyloid beta><amyloid-b protein><analytical tool><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><beta amyloid fibril><biological signal transduction><brain based><brain endothelial cell><brain microvascular endothelial cell><brain vascular endothelial cell><candidate identification><cell type><cerebral><cerebral endothelial cell><cerebral microvascular endothelial cell><cerebral vascular endothelial cell><clinical efficacy><clinical validation><cohort><combination chemotherapy><combination pharmacotherapy><combination therapy><combined modality treatment><combined treatment><compound repositioning><compound repurposing><cultured cell line><data base><data collected in real world><deep learning><deep learning method><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><drug candidate><drug detection><drug discovery><drug epidemiology><drug intervention><drug repositioning><drug repurposing><drug testing><drug treatment><drug use><drug/agent><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><experiment><experimental research><experimental study><experiments><fluticasone><genome mutation><genome scale><genome-wide><genomewide><genomic data><genomic dataset><gitter cell><human disease><iPS><iPSC><iPSCs><in vitro Assay><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><inducible pluripotent cell><inducible pluripotent stem cell><intervention design><knockin mice><knowledge graph><late onset alzheimer><machine based learning><mesoglia><metropolitan><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mouse model><multi-modal therapy><multi-modal treatment><multi-modality><multimodality><multiomics><multiple omics><murine model><mutant><nerve cement><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal degeneration><neuropathologic tau><neuropathological tau><new therapeutic uses for existing drugs><new use of drug><new uses for an approved drug><new uses for existing drugs><novel><observational research study><observational survey><panomics><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patient-derived pluripotent stem cells><patients with AD><perivascular glial cell><pharmaceutical intervention><pharmacoepidemiologic><pharmacoepidemiological><pharmacologic><pharmacological intervention><pharmacological repurposing><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><population based><pre-clinical efficacy><preclinical efficacy><prevent><preventing><primary degenerative dementia><real world data><repositionable compounds><repositionable drugs><repositioning approved drugs><repositioning existing drugs><repurposable drugs><repurposable medication><repurposable medicine><repurposable therapeutic><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><risk allele><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk gene><risk genotype><risk loci><risk locus><risk of developing Alzheimer's><risk variant><sNuc-Seq><senile dementia of the Alzheimer type><side effect><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><soluble amyloid precursor protein><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic repositioning><therapeutic repurposing><therapy design><three dimensional><treatment design><treatment effect><trial design><validations><τ Proteins>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Li Gan

CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$794,088

FY 2026

Project Title

TREM2 Genotype-Informed Drug Repurposing and Combination Therapy Design for Alzheimers Disease

Grant Number:

5R01AG076448-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The cumulative evidence indicates neuro-inflammation play crucial roles in Alzheimer’s disease (AD) and anti- inflammatory agents (i.e., microglia-targeted therapies) show potential treatments for AD. The treatment window for microglia-targeted therapies may at least be open later in...

Research Terms

<3-D><3-Dimensional><3D><AD dementia><AD pathology><AD patients><AD risk><AD risk factor><AD therapy><AD treatment><AKT inhibition><APOE><Affect><African American><Afro American><Afroamerican><Age><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease risk><Alzheimer's disease therapeutic><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's patient><Alzheimer's therapeutic><Alzheimer's therapy><Alzheimers Dementia><American><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Apo-E><ApoE protein><Apolipoprotein E><Area><Asthma><Attention><Aβ><Biology><Brain><Brain Nervous System><Bronchial Asthma><Cell Body><Cell Communication and Signaling><Cell Line><Cell Nucleus><Cell Signaling><CellLine><Cells><Cerebrum><Clinic><Clinical Trials><Combination Drug Therapy><Combined Modality Therapy><Communication><Computers><DNA mutation><Data><Data Bases><Databases><Degenerative Neurologic Disorders><Development><Disease><Disease Outcome><Disease Progression><Disease associated microglia><Disorder><Dose><Drug Combinations><Drug Screening><Drug Targeting><Drug Therapy><Drug usage><Drugs><Electronic Health Record><Encephalon><Gene Targeting><Gene Transcription><Generations><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genomics><Genotype><Glia><Glial Cells><Health system><Hortega cell><Human><Human Genetics><Immune><Immunes><Incidence><Inflammation><Inflammatory><Intracellular Communication and Signaling><Investigation><KI mice><Knock-in Mouse><Knowledge Portal><Knowledge base Portal><Knowledgebase Portal><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Link><MT-bound tau><Machine Learning><Medication><Medicine><Methodology><Methods><Mice><Mice Mammals><Microglia><Modern Man><Molecular><Molecular Target><Multimodal Therapy><Multimodal Treatment><Murine><Mus><Mutation><Nature><Nerve Degeneration><Nervous System Degenerative Diseases><Network-based><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroglia><Neuroglial Cells><Neurologic Degenerative Conditions><Neuron Degeneration><New York City><Non-neuronal cell><Nonneuronal cell><Nucleus><Observational Study><Organoids><Pathogenesis><Patients><Penetration><Persons><Pharmaceutical Epidemiology><Pharmaceutical Preparations><Pharmacoepidemiology><Pharmacological Treatment><Pharmacotherapy><Play><Polychemotherapy><Population><Primary Senile Degenerative Dementia><Process><Property><RNA Expression><Research><Risk><Risk-associated variant><Role><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Source><Strains Cell Lines><System><Systems Biology><TREM2><TREM2 gene><Tauopathies><Testing><Toxic effect><Toxicities><Transcription><Triggering Receptor Expressed in Myeloid Cells 2><Triggering Receptor Expressed on Myeloid Cells 2><United States><Validation><Variant><Variation><a beta peptide><abeta><ages><alzheimer risk><amyloid beta><amyloid-b protein><analytical tool><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><beta amyloid fibril><biological signal transduction><brain based><brain endothelial cell><brain microvascular endothelial cell><brain vascular endothelial cell><candidate identification><cell type><cerebral><cerebral endothelial cell><cerebral microvascular endothelial cell><cerebral vascular endothelial cell><clinical efficacy><clinical validation><cohort><combination chemotherapy><combination pharmacotherapy><combination therapy><combined modality treatment><combined treatment><compound repositioning><compound repurposing><cultured cell line><data base><data collected in real world><deep learning><deep learning method><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><drug candidate><drug detection><drug discovery><drug epidemiology><drug intervention><drug repositioning><drug repurposing><drug testing><drug treatment><drug use><drug/agent><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><experiment><experimental research><experimental study><experiments><fluticasone><genome mutation><genome scale><genome-wide><genomewide><genomic data><genomic dataset><gitter cell><human disease><iPS><iPSC><iPSCs><in vitro Assay><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><inducible pluripotent cell><inducible pluripotent stem cell><intervention design><knockin mice><knowledge graph><late onset alzheimer><machine based learning><mesoglia><metropolitan><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mouse model><multi-modal therapy><multi-modal treatment><multi-modality><multimodality><multiomics><multiple omics><murine model><mutant><nerve cement><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal degeneration><neuropathologic tau><neuropathological tau><new therapeutic uses for existing drugs><new use of drug><new uses for an approved drug><new uses for existing drugs><novel><observational research study><observational survey><panomics><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patient-derived pluripotent stem cells><patients with AD><perivascular glial cell><pharmaceutical intervention><pharmacoepidemiologic><pharmacoepidemiological><pharmacologic><pharmacological intervention><pharmacological repurposing><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><population based><pre-clinical efficacy><preclinical efficacy><prevent><preventing><primary degenerative dementia><real world data><repositionable compounds><repositionable drugs><repositioning approved drugs><repositioning existing drugs><repurposable drugs><repurposable medication><repurposable medicine><repurposable therapeutic><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><risk allele><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk gene><risk genotype><risk loci><risk locus><risk of developing Alzheimer's><risk variant><sNuc-Seq><senile dementia of the Alzheimer type><side effect><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><soluble amyloid precursor protein><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic repositioning><therapeutic repurposing><therapy design><three dimensional><treatment design><treatment effect><trial design><validations><τ Proteins>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Fei Wang

CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$794,088

FY 2026

Project Title

TREM2 Genotype-Informed Drug Repurposing and Combination Therapy Design for Alzheimers Disease

Grant Number:

5R01AG076448-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The cumulative evidence indicates neuro-inflammation play crucial roles in Alzheimer’s disease (AD) and anti- inflammatory agents (i.e., microglia-targeted therapies) show potential treatments for AD. The treatment window for microglia-targeted therapies may at least be open later in...

Research Terms

<3-D><3-Dimensional><3D><AD dementia><AD pathology><AD patients><AD risk><AD risk factor><AD therapy><AD treatment><AKT inhibition><APOE><Affect><African American><Afro American><Afroamerican><Age><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease risk><Alzheimer's disease therapeutic><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's patient><Alzheimer's therapeutic><Alzheimer's therapy><Alzheimers Dementia><American><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Apo-E><ApoE protein><Apolipoprotein E><Area><Asthma><Attention><Aβ><Biology><Brain><Brain Nervous System><Bronchial Asthma><Cell Body><Cell Communication and Signaling><Cell Line><Cell Nucleus><Cell Signaling><CellLine><Cells><Cerebrum><Clinic><Clinical Trials><Combination Drug Therapy><Combined Modality Therapy><Communication><Computers><DNA mutation><Data><Data Bases><Databases><Degenerative Neurologic Disorders><Development><Disease><Disease Outcome><Disease Progression><Disease associated microglia><Disorder><Dose><Drug Combinations><Drug Screening><Drug Targeting><Drug Therapy><Drug usage><Drugs><Electronic Health Record><Encephalon><Gene Targeting><Gene Transcription><Generations><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genomics><Genotype><Glia><Glial Cells><Health system><Hortega cell><Human><Human Genetics><Immune><Immunes><Incidence><Inflammation><Inflammatory><Intracellular Communication and Signaling><Investigation><KI mice><Knock-in Mouse><Knowledge Portal><Knowledge base Portal><Knowledgebase Portal><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Link><MT-bound tau><Machine Learning><Medication><Medicine><Methodology><Methods><Mice><Mice Mammals><Microglia><Modern Man><Molecular><Molecular Target><Multimodal Therapy><Multimodal Treatment><Murine><Mus><Mutation><Nature><Nerve Degeneration><Nervous System Degenerative Diseases><Network-based><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroglia><Neuroglial Cells><Neurologic Degenerative Conditions><Neuron Degeneration><New York City><Non-neuronal cell><Nonneuronal cell><Nucleus><Observational Study><Organoids><Pathogenesis><Patients><Penetration><Persons><Pharmaceutical Epidemiology><Pharmaceutical Preparations><Pharmacoepidemiology><Pharmacological Treatment><Pharmacotherapy><Play><Polychemotherapy><Population><Primary Senile Degenerative Dementia><Process><Property><RNA Expression><Research><Risk><Risk-associated variant><Role><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Source><Strains Cell Lines><System><Systems Biology><TREM2><TREM2 gene><Tauopathies><Testing><Toxic effect><Toxicities><Transcription><Triggering Receptor Expressed in Myeloid Cells 2><Triggering Receptor Expressed on Myeloid Cells 2><United States><Validation><Variant><Variation><a beta peptide><abeta><ages><alzheimer risk><amyloid beta><amyloid-b protein><analytical tool><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><beta amyloid fibril><biological signal transduction><brain based><brain endothelial cell><brain microvascular endothelial cell><brain vascular endothelial cell><candidate identification><cell type><cerebral><cerebral endothelial cell><cerebral microvascular endothelial cell><cerebral vascular endothelial cell><clinical efficacy><clinical validation><cohort><combination chemotherapy><combination pharmacotherapy><combination therapy><combined modality treatment><combined treatment><compound repositioning><compound repurposing><cultured cell line><data base><data collected in real world><deep learning><deep learning method><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><drug candidate><drug detection><drug discovery><drug epidemiology><drug intervention><drug repositioning><drug repurposing><drug testing><drug treatment><drug use><drug/agent><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><experiment><experimental research><experimental study><experiments><fluticasone><genome mutation><genome scale><genome-wide><genomewide><genomic data><genomic dataset><gitter cell><human disease><iPS><iPSC><iPSCs><in vitro Assay><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><inducible pluripotent cell><inducible pluripotent stem cell><intervention design><knockin mice><knowledge graph><late onset alzheimer><machine based learning><mesoglia><metropolitan><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mouse model><multi-modal therapy><multi-modal treatment><multi-modality><multimodality><multiomics><multiple omics><murine model><mutant><nerve cement><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal degeneration><neuropathologic tau><neuropathological tau><new therapeutic uses for existing drugs><new use of drug><new uses for an approved drug><new uses for existing drugs><novel><observational research study><observational survey><panomics><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patient-derived pluripotent stem cells><patients with AD><perivascular glial cell><pharmaceutical intervention><pharmacoepidemiologic><pharmacoepidemiological><pharmacologic><pharmacological intervention><pharmacological repurposing><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><population based><pre-clinical efficacy><preclinical efficacy><prevent><preventing><primary degenerative dementia><real world data><repositionable compounds><repositionable drugs><repositioning approved drugs><repositioning existing drugs><repurposable drugs><repurposable medication><repurposable medicine><repurposable therapeutic><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><risk allele><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk gene><risk genotype><risk loci><risk locus><risk of developing Alzheimer's><risk variant><sNuc-Seq><senile dementia of the Alzheimer type><side effect><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><soluble amyloid precursor protein><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic repositioning><therapeutic repurposing><therapy design><three dimensional><treatment design><treatment effect><trial design><validations><τ Proteins>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

ROBIA G PAUTLER

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$782,443

FY 2026

Project Title

Incorporating Spatial Proteomics to Understand the Basis of Hyper and Hypoconnectivity in mouse models of AD

Grant Number:

5R01AG081192-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

In this proposal, we propose studies to elucidate the basis of the hyper and hypoconnectivity observed in AD. We will combine high resolution in vivo MRI imaging strategies with state-of the-art spatial proteomics. By combining these methods, we will obtain these two types of data in the same animal...

Research Terms

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Md. Abul Hassan Samee

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$782,443

FY 2026

Project Title

Incorporating Spatial Proteomics to Understand the Basis of Hyper and Hypoconnectivity in mouse models of AD

Grant Number:

5R01AG081192-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

In this proposal, we propose studies to elucidate the basis of the hyper and hypoconnectivity observed in AD. We will combine high resolution in vivo MRI imaging strategies with state-of the-art spatial proteomics. By combining these methods, we will obtain these two types of data in the same animal...

Research Terms

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Hong-Bo Zhao

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$775,658

FY 2026

Project Title

The effect of noise induced hearing loss on Alzheimer's disease development and progression

Grant Number:

4R01AG082216-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary Alzheimer's disease (AD) is a common neurodegenerative disease characterized by a progressive loss of memory and cognitive decline. Over the last decade, the prevalence of AD and AD-related dementia (ADRD) has been rapidly growing. It is predicted that there will be 150 million AD patients ...

Research Terms

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Da Ma

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$770,558

FY 2026

Project Title

Neuroimage-genomic fingerprints for subtyping and prediction of Alzheimer's Disease and related dementia

Grant Number:

5R01AG093792-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Alzheimer’s disease (AD) is a multifactorial neurodegenerative disease with heterogeneous pathologies that affect the cognitive function of the brain, eventually leading to dementia. The heterogeneity of AD is manifested both in terms of diverse neurodegeneration patterns an...

Research Terms

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Pengfei Liu

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$747,195

FY 2026

Project Title

Determine the role of atmospheric particulate matter pollutants in contributing to Lewy Body Dementia

Grant Number:

4R01AG079487-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

There is a consensus that environmental pollutants are a risk factor for Alzheimer's Disease Related Dementias (ADRD). Emerging evidence has shown that environmental stressors (e.g., urban and roadside air pollution) contribute to dementia. Our supporting epidemiological results have determined that...

Research Terms

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Xiaobo Mao

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$747,195

FY 2026

Project Title

Determine the role of atmospheric particulate matter pollutants in contributing to Lewy Body Dementia

Grant Number:

4R01AG079487-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

There is a consensus that environmental pollutants are a risk factor for Alzheimer's Disease Related Dementias (ADRD). Emerging evidence has shown that environmental stressors (e.g., urban and roadside air pollution) contribute to dementia. Our supporting epidemiological results have determined that...

Research Terms

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Zhang Xuan

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$747,195

FY 2026

Project Title

Determine the role of atmospheric particulate matter pollutants in contributing to Lewy Body Dementia

Grant Number:

4R01AG079487-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

There is a consensus that environmental pollutants are a risk factor for Alzheimer's Disease Related Dementias (ADRD). Emerging evidence has shown that environmental stressors (e.g., urban and roadside air pollution) contribute to dementia. Our supporting epidemiological results have determined that...

Research Terms

View Full Project Details on NIH Reporter

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Iuliana Ionita

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$725,202

FY 2026

Project Title

Statistical Framework for Unraveling Age-Dependent Genetic Landscape of Alzheimer's Disease and Related Dementias: Harnessing Large-Scale EHR and DNA-Biobank Integration

Grant Number:

5R01AG087496-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary This proposal seeks to improve our understanding of Alzheimer's Disease (AD) and related dementias (ADRD) by developing a more comprehensive view of its genetic architecture. It aims to leverage large-scale biobanks and Electronic Medical Records (EMR) to systematically study the gen...

Research Terms

<2-dimensional><AD and related dementia><AD dementia><AD pathway><AD related dementia><AD-associated pathways><AD-related pathways><AD-specific pathways><ADRD><Address><Affect><Age><Aging><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Amentia><Area><Biological><Blood Vessels><Complex><Computerized Medical Record><DNA><Data><Degenerative Neurologic Disorders><Dementia><Deoxyribonucleic Acid><Dependence><Detection><Development><Disease><Disease Progression><Disorder><Electronic Medical Record><Ensure><GWA study><GWAS><Gene Expression><Gene variant><Genetic><Genetic Diseases><Genetic Structures><Genetic study><Genotype><Goals><Heritability><Heterogeneity><Immune system><Individual><Knowledge><Late Onset Alzheimer Disease><Late onset AD><Life><Life Cycle><Life Cycle Stages><Link><Machine Learning><Metabolic><Methodology><Methods><Modeling><Motivation><Nervous System Degenerative Diseases><Network-based><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Persons><Phenotype><Physiologic><Physiological><Population><Population Heterogeneity><Predisposition gene><Preventative strategy><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Process><Records><Research><Research Design><Study Type><Susceptibility Gene><Techniques><Therapeutic Intervention><Time><Validation><Variant><Variation><age associated><age associated alterations><age associated changes><age associated dementia><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age induced dementia><age linked><age related><age related alterations><age related changes><age related dementia><age specific><age specific alterations><age specific changes><ages><aging associated alterations><aging associated changes><aging associated dementia><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related dementia><aging specific alterations><aging specific changes><allelic variant><alterations with age><analytical method><analytical tool><biobank><biologic><biorepository><changes with age><co-morbid><co-morbidity><comorbidity><data fusion><data imputation><data resource><deep learning><deep learning method><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><diverse populations><early onset><effective therapy><effective treatment><genetic architecture><genetic condition><genetic disorder><genetic variant><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic variant><heterogeneous population><high dimensionality><improved><imputation method><innovate><innovation><innovative><insight><intervention therapy><late onset alzheimer><learning algorithm><life course><life span><lifespan><machine based learning><mechanisms in AD><mechanisms in Alzheimer's disease><neural network><neurodegenerative illness><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><phenome><phenotyping algorithm><population diversity><predisposing gene><primary degenerative dementia><senile dementia of the Alzheimer type><statistical learning><study design><supervised learning><supervised machine learning><susceptibility allele><susceptibility locus><susceptibility variant><therapeutic target><tool><treatment strategy><two-dimensional><validations><vascular><whole genome association analysis><whole genome association study>

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Kaizheng Wang

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$725,202

FY 2026

Project Title

Statistical Framework for Unraveling Age-Dependent Genetic Landscape of Alzheimer's Disease and Related Dementias: Harnessing Large-Scale EHR and DNA-Biobank Integration

Grant Number:

5R01AG087496-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary This proposal seeks to improve our understanding of Alzheimer's Disease (AD) and related dementias (ADRD) by developing a more comprehensive view of its genetic architecture. It aims to leverage large-scale biobanks and Electronic Medical Records (EMR) to systematically study the gen...

Research Terms

<2-dimensional><AD and related dementia><AD dementia><AD pathway><AD related dementia><AD-associated pathways><AD-related pathways><AD-specific pathways><ADRD><Address><Affect><Age><Aging><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Amentia><Area><Biological><Blood Vessels><Complex><Computerized Medical Record><DNA><Data><Degenerative Neurologic Disorders><Dementia><Deoxyribonucleic Acid><Dependence><Detection><Development><Disease><Disease Progression><Disorder><Electronic Medical Record><Ensure><GWA study><GWAS><Gene Expression><Gene variant><Genetic><Genetic Diseases><Genetic Structures><Genetic study><Genotype><Goals><Heritability><Heterogeneity><Immune system><Individual><Knowledge><Late Onset Alzheimer Disease><Late onset AD><Life><Life Cycle><Life Cycle Stages><Link><Machine Learning><Metabolic><Methodology><Methods><Modeling><Motivation><Nervous System Degenerative Diseases><Network-based><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Persons><Phenotype><Physiologic><Physiological><Population><Population Heterogeneity><Predisposition gene><Preventative strategy><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Process><Records><Research><Research Design><Study Type><Susceptibility Gene><Techniques><Therapeutic Intervention><Time><Validation><Variant><Variation><age associated><age associated alterations><age associated changes><age associated dementia><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age induced dementia><age linked><age related><age related alterations><age related changes><age related dementia><age specific><age specific alterations><age specific changes><ages><aging associated alterations><aging associated changes><aging associated dementia><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related dementia><aging specific alterations><aging specific changes><allelic variant><alterations with age><analytical method><analytical tool><biobank><biologic><biorepository><changes with age><co-morbid><co-morbidity><comorbidity><data fusion><data imputation><data resource><deep learning><deep learning method><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><diverse populations><early onset><effective therapy><effective treatment><genetic architecture><genetic condition><genetic disorder><genetic variant><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic variant><heterogeneous population><high dimensionality><improved><imputation method><innovate><innovation><innovative><insight><intervention therapy><late onset alzheimer><learning algorithm><life course><life span><lifespan><machine based learning><mechanisms in AD><mechanisms in Alzheimer's disease><neural network><neurodegenerative illness><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><phenome><phenotyping algorithm><population diversity><predisposing gene><primary degenerative dementia><senile dementia of the Alzheimer type><statistical learning><study design><supervised learning><supervised machine learning><susceptibility allele><susceptibility locus><susceptibility variant><therapeutic target><tool><treatment strategy><two-dimensional><validations><vascular><whole genome association analysis><whole genome association study>

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Ying Wei

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$725,202

FY 2026

Project Title

Statistical Framework for Unraveling Age-Dependent Genetic Landscape of Alzheimer's Disease and Related Dementias: Harnessing Large-Scale EHR and DNA-Biobank Integration

Grant Number:

5R01AG087496-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary This proposal seeks to improve our understanding of Alzheimer's Disease (AD) and related dementias (ADRD) by developing a more comprehensive view of its genetic architecture. It aims to leverage large-scale biobanks and Electronic Medical Records (EMR) to systematically study the gen...

Research Terms

<2-dimensional><AD and related dementia><AD dementia><AD pathway><AD related dementia><AD-associated pathways><AD-related pathways><AD-specific pathways><ADRD><Address><Affect><Age><Aging><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Amentia><Area><Biological><Blood Vessels><Complex><Computerized Medical Record><DNA><Data><Degenerative Neurologic Disorders><Dementia><Deoxyribonucleic Acid><Dependence><Detection><Development><Disease><Disease Progression><Disorder><Electronic Medical Record><Ensure><GWA study><GWAS><Gene Expression><Gene variant><Genetic><Genetic Diseases><Genetic Structures><Genetic study><Genotype><Goals><Heritability><Heterogeneity><Immune system><Individual><Knowledge><Late Onset Alzheimer Disease><Late onset AD><Life><Life Cycle><Life Cycle Stages><Link><Machine Learning><Metabolic><Methodology><Methods><Modeling><Motivation><Nervous System Degenerative Diseases><Network-based><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Persons><Phenotype><Physiologic><Physiological><Population><Population Heterogeneity><Predisposition gene><Preventative strategy><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Process><Records><Research><Research Design><Study Type><Susceptibility Gene><Techniques><Therapeutic Intervention><Time><Validation><Variant><Variation><age associated><age associated alterations><age associated changes><age associated dementia><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age induced dementia><age linked><age related><age related alterations><age related changes><age related dementia><age specific><age specific alterations><age specific changes><ages><aging associated alterations><aging associated changes><aging associated dementia><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related dementia><aging specific alterations><aging specific changes><allelic variant><alterations with age><analytical method><analytical tool><biobank><biologic><biorepository><changes with age><co-morbid><co-morbidity><comorbidity><data fusion><data imputation><data resource><deep learning><deep learning method><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><diverse populations><early onset><effective therapy><effective treatment><genetic architecture><genetic condition><genetic disorder><genetic variant><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic variant><heterogeneous population><high dimensionality><improved><imputation method><innovate><innovation><innovative><insight><intervention therapy><late onset alzheimer><learning algorithm><life course><life span><lifespan><machine based learning><mechanisms in AD><mechanisms in Alzheimer's disease><neural network><neurodegenerative illness><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><phenome><phenotyping algorithm><population diversity><predisposing gene><primary degenerative dementia><senile dementia of the Alzheimer type><statistical learning><study design><supervised learning><supervised machine learning><susceptibility allele><susceptibility locus><susceptibility variant><therapeutic target><tool><treatment strategy><two-dimensional><validations><vascular><whole genome association analysis><whole genome association study>

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HARALD W SONTHEIMER

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$709,066

FY 2026

Project Title

Extracellular matrix and memory impairments in Alzheimer disease

Grant Number:

5R01AG085359-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Alzheimer disease (AD) is the most common form of dementia worldwide[1]. AD is histopathologically defined by plaque- forming amyloid beta-protein (Aβ) and neurofibrillary tangles of phosphorylated tau protein. Amyloid and tau pathology typically begins in hippocampus and en...

Research Terms

<3-D analysis><3-dimensional analysis><3D analysis><3xTg><3xTg-AD mice><3xTg-AD mouse><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD brain><AD dementia><AD model><AD pathology><Abscission><Acceleration><Address><Age><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's pathology><Alzheimers Dementia><Amentia><Aminalon><Aminalone><Ammon Horn><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animals><Anterior><Astrocytes><Astrocytus><Astroglia><Autopsy><Aβ><Body Tissues><Brain><Brain Inflammation><Brain Nervous System><Brain region><C-jun Amino-Terminal Kinase><C-jun Kinase-1><C-jun N-Terminal Kinase 1><Candidate Disease Gene><Candidate Gene><Cell-Extracellular Matrix><Chondroitin ABC Lyase><Chondroitinase ABC><Clinical><Cornu Ammonis><Dementia><ECM><Encapsulated><Encephalitis><Encephalon><Ensure><Entorhinal Area><Enzyme Gene><Enzymes><Esteroproteases><Excision><Extirpation><Extracellular Matrix><GABA><Generalized Growth><Genes><Growth><Hippocampus><Histocytochemistry><Hortega cell><Human><Impairment><In Situ><Individual><Inflammation><Injections><JN Kinase><JNK><JNK Mitogen-Activated Protein Kinases><JNK1><JNK1 Kinase><JNK1 protein><JNK1A2><JNK21B1/2><Lateral><Learning><LoxP-flanked allele><MAP Kinase 8><MAP Kinase 8 Gene><MAPK8><MAPK8 Mitogen-Activated Protein Kinase><MAPK8 gene><MMPs><MT-bound tau><Maintenance><Matrix Metalloproteinases><Measures><Memory><Memory Deficit><Memory Loss><Memory impairment><Mice><Mice Mammals><Microglia><Mitogen-Activated Protein Kinase 8><Modern Man><Molecular><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurofibrillary Tangles><Neurons><PRKM8><Paper><Pathologic><Pathology><Peptidases><Peptide Hydrolases><Phenocopy><Phenotype><Play><Population><Primary Senile Degenerative Dementia><Process><Protease Gene><Proteases><Protein Cleavage><Proteinases><Proteoglycan><Proteolysis><Proteolytic Enzymes><Pyramidal Cells><Pyramidal neuron><Reactive Inhibition><Receptor Protein><Removal><Reporting><Resolution><Role><SAP Kinase-1><SAPK/JNK><SAPK1 Mitogen-Activated Protein Kinase><SAPK1/JNK><STAT3><STAT3 gene><Stress-Activated Protein Kinase JNK1><Stress-Activated Protein Kinase gamma><Structure><Surgical Removal><Synapses><Synaptic><Synaptic Receptors><Tauopathies><Three-dimensional analysis><Time><Tissue Growth><Tissues><Tyrphostins><a beta peptide><abeta><ages><alzheimer model><amyloid beta><amyloid pathology><amyloid-b protein><astrocytic glia><astrogliosis><behavior study><behavioral study><beta amyloid fibril><brain tissue><c-jun N-Terminal Kinase><candidate identification><cell type><entorhinal cortex><experiment><experimental research><experimental study><experiments><extracellular><floxed><floxed allele><gamma-Aminobutyric Acid><gitter cell><global gene expression><global transcription profile><hippocampal><hippocampal pyramidal neuron><histochemistry><histochemistry/cytochemistry><human disease><inhibitor><inhibitory neuron><jun-NH2-Terminal Kinase><life span><lifespan><memory decline><memory dysfunction><memory recognition><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><mouse model><murine model><natural aging><necropsy><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuronal><neuropathologic tau><neuropathological tau><normal aging><normative aging><novel><ontogeny><p-tau><p-τ><patch clamp><perivascular glial cell><phospho-tau><phospho-τ><phosphorylated tau><post-translational modification of tau><postmortem><posttranslational modification of tau><pre-clinical><preclinical><prevent><preventing><primary degenerative dementia><receptor><receptor density><resection><resolutions><senile dementia of the Alzheimer type><social><social cognition><social role><soluble amyloid precursor protein><spatial and temporal><spatial temporal><spatiotemporal><stress-activated protein kinase 1><synapse><tangle><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau phosphorylation><tau posttranslational modification><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><timeline><transcriptome><uptake><γ-Aminobutyric Acid><τ Proteins><τ phosphorylation>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Miles Berger

DUKE UNIVERSITY, DURHAM, NC

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$678,075

FY 2026

Project Title

APOE4 dependent regulation of CSF Complement Pathway Activation in the development of Alzheimer's Disease

Grant Number:

5R01AG076903-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Dementia is a common disorder that increases in frequency in the elderly. Dementia is a progressive loss of thinking and memory skills that eventually results in an inability to care for oneself and to live independently. The most common cause of dementia in older Americans ...

Research Terms

<18 year old><18 years of age><21+ years old><AD dementia><AD pathology><AD prevention><AD risk><AD risk factor><APOE><APOE e3><APOE e4><APOE-ε4><APOEε4><Acquired brain injury><Adult><Adult Human><Age><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease prevention><Alzheimer prevention><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's pathology><Alzheimers Dementia><Amentia><American><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Apo-E><ApoE protein><Apolipoprotein E><Appearance><Assay><Autopsy><Aβ><Bacteria><Bathing><Baths><Bioassay><Biological Assay><Biological Markers><Biology><Brain><Brain Inflammation><Brain Injuries><Brain Nervous System><C1 q><C1q><Caring><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cerebrospinal Fluid><Chemicals><Classical Complement Pathway><Code><Coding System><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complement><Complement 1q><Complement Activation><Complement C1q><Complement Inactivators><Complement Inhibitors><Complement Proteins><DNA><Data><Dementia><Deoxyribonucleic Acid><Deposit><Deposition><Development><Disease><Disease Resistance><Disorder><Disturbance in cognition><Drug Targeting><Drugs><ELISA><Eating><Elderly><Encephalitis><Encephalon><Enrollment><Environmental Factor><Environmental Risk Factor><Enzyme-Linked Immunosorbent Assay><Food Intake><Frequencies><Gender><Gene variant><Genetic><Genetic Carriers><Genetic predisposing factor><HLA-DR Associated Protein II><Hereditary><Hereditary Disease><Human><Hybrids><IGAAD><Immune><Immunes><Impaired cognition><In Vitro><Inborn Genetic Diseases><Inherited><Inherited disorder><Inhibitor of GZMA-Activated DNase><Intracellular Communication and Signaling><Late Onset Alzheimer Disease><Late onset AD><Lead><Life><Life Style><Lifestyle><Liquid substance><Lumbar Puncture><MT-bound tau><Measures><Medication><Medulla Spinalis><Memory><Methods><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurites><Neuritic Plaques><Neurocyte><Neurofibrillary Tangles><Neurologic Disorders><Neurological Disorders><Neurons><Operative Procedures><Operative Surgical Procedures><Outcome><Pathology><Pathway interactions><Patients><Pb element><Peripheral><Persons><Pharmaceutical Preparations><Phase 2 Clinical Trials><Phase II Clinical Trials><Phosphatase 2A Inhibitor I2PP2A><Postoperative><Postoperative Period><Primary Senile Degenerative Dementia><Process><Proteins><Proteomics><Regulation><Risk><Role><SET Translocation Inhibitor-2 of Protein Phosphatase-2A><Sampling><Senile Plaques><Set protein><Signal Transduction><Signal Transduction Systems><Signaling><Spinal Cord><Spinal Puncture><Surgical><Surgical Interventions><Surgical Procedure><Synapses><Synaptic><Tauopathies><Template Activating Factor I Beta><Testing><Thinking><Work><a beta peptide><abeta><abeta deposition><adulthood><advanced age><age 18><age 18 years><ages><allele carriers><allelic variant><alzheimer risk><amyloid beta><amyloid beta deposition><amyloid beta plaque><amyloid β deposition><amyloid-b plaque><amyloid-b protein><apo E-3><apo E-4><apo E3><apo E4><apo epsilon4><apoE epsilon 4><apoE-3><apoE-4><apoE3><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-3><apolipoprotein E-4><apolipoprotein E3><apolipoprotein E4><aβ deposition><aβ plaques><beta amyloid fibril><bio-markers><biologic marker><biological signal transduction><biomarker><brain damage><brain-injured><cerebral spinal fluid><cognitive dysfunction><cognitive loss><cohort><complement pathway><complement pathway regulation><complementation><cored plaque><developmental><diffuse plaque><drug/agent><eighteen year old><eighteen years of age><enroll><environmental risk><enzyme linked immunoassay><fluid><genetic risk factor><genetic variant><genomic variant><geriatric><heavy metal Pb><heavy metal lead><hereditary disorder><heritable disorder><in vivo><inborn error><inherited diseases><inherited factor><inherited genetic disease><inherited genetic disorder><insight><late onset alzheimer><life span><lifespan><liquid><microtubule bound tau><microtubule-bound tau><mimetics><necropsy><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurological disease><neuronal><neuropathologic tau><neuropathological tau><novel><older adult><older adulthood><p-tau><p-τ><pathway><peptide mimetic><peptide mimic><peptidomimetics><phase II protocol><phospho-tau><phospho-τ><phosphorylated tau><post-operative delirium><post-translational modification of tau><postmortem><postoperative delirium><posttranslational modification of tau><prevent><preventing><primary degenerative dementia><protein function><resistance to disease><resistant disease><resistant to disease><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><senior citizen><sex><skills><social role><soluble amyloid precursor protein><spinal fluid><surgery><synapse><tangle><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau phosphorylation><tau posttranslational modification><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><thoughts><trait><τ Proteins><τ phosphorylation>

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Jamie R Privratsky

DUKE UNIVERSITY, DURHAM, NC

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$678,075

FY 2026

Project Title

APOE4 dependent regulation of CSF Complement Pathway Activation in the development of Alzheimer's Disease

Grant Number:

5R01AG076903-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Dementia is a common disorder that increases in frequency in the elderly. Dementia is a progressive loss of thinking and memory skills that eventually results in an inability to care for oneself and to live independently. The most common cause of dementia in older Americans ...

Research Terms

<18 year old><18 years of age><21+ years old><AD dementia><AD pathology><AD prevention><AD risk><AD risk factor><APOE><APOE e3><APOE e4><APOE-ε4><APOEε4><Acquired brain injury><Adult><Adult Human><Age><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease prevention><Alzheimer prevention><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's pathology><Alzheimers Dementia><Amentia><American><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Apo-E><ApoE protein><Apolipoprotein E><Appearance><Assay><Autopsy><Aβ><Bacteria><Bathing><Baths><Bioassay><Biological Assay><Biological Markers><Biology><Brain><Brain Inflammation><Brain Injuries><Brain Nervous System><C1 q><C1q><Caring><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cerebrospinal Fluid><Chemicals><Classical Complement Pathway><Code><Coding System><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complement><Complement 1q><Complement Activation><Complement C1q><Complement Inactivators><Complement Inhibitors><Complement Proteins><DNA><Data><Dementia><Deoxyribonucleic Acid><Deposit><Deposition><Development><Disease><Disease Resistance><Disorder><Disturbance in cognition><Drug Targeting><Drugs><ELISA><Eating><Elderly><Encephalitis><Encephalon><Enrollment><Environmental Factor><Environmental Risk Factor><Enzyme-Linked Immunosorbent Assay><Food Intake><Frequencies><Gender><Gene variant><Genetic><Genetic Carriers><Genetic predisposing factor><HLA-DR Associated Protein II><Hereditary><Hereditary Disease><Human><Hybrids><IGAAD><Immune><Immunes><Impaired cognition><In Vitro><Inborn Genetic Diseases><Inherited><Inherited disorder><Inhibitor of GZMA-Activated DNase><Intracellular Communication and Signaling><Late Onset Alzheimer Disease><Late onset AD><Lead><Life><Life Style><Lifestyle><Liquid substance><Lumbar Puncture><MT-bound tau><Measures><Medication><Medulla Spinalis><Memory><Methods><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurites><Neuritic Plaques><Neurocyte><Neurofibrillary Tangles><Neurologic Disorders><Neurological Disorders><Neurons><Operative Procedures><Operative Surgical Procedures><Outcome><Pathology><Pathway interactions><Patients><Pb element><Peripheral><Persons><Pharmaceutical Preparations><Phase 2 Clinical Trials><Phase II Clinical Trials><Phosphatase 2A Inhibitor I2PP2A><Postoperative><Postoperative Period><Primary Senile Degenerative Dementia><Process><Proteins><Proteomics><Regulation><Risk><Role><SET Translocation Inhibitor-2 of Protein Phosphatase-2A><Sampling><Senile Plaques><Set protein><Signal Transduction><Signal Transduction Systems><Signaling><Spinal Cord><Spinal Puncture><Surgical><Surgical Interventions><Surgical Procedure><Synapses><Synaptic><Tauopathies><Template Activating Factor I Beta><Testing><Thinking><Work><a beta peptide><abeta><abeta deposition><adulthood><advanced age><age 18><age 18 years><ages><allele carriers><allelic variant><alzheimer risk><amyloid beta><amyloid beta deposition><amyloid beta plaque><amyloid β deposition><amyloid-b plaque><amyloid-b protein><apo E-3><apo E-4><apo E3><apo E4><apo epsilon4><apoE epsilon 4><apoE-3><apoE-4><apoE3><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-3><apolipoprotein E-4><apolipoprotein E3><apolipoprotein E4><aβ deposition><aβ plaques><beta amyloid fibril><bio-markers><biologic marker><biological signal transduction><biomarker><brain damage><brain-injured><cerebral spinal fluid><cognitive dysfunction><cognitive loss><cohort><complement pathway><complement pathway regulation><complementation><cored plaque><developmental><diffuse plaque><drug/agent><eighteen year old><eighteen years of age><enroll><environmental risk><enzyme linked immunoassay><fluid><genetic risk factor><genetic variant><genomic variant><geriatric><heavy metal Pb><heavy metal lead><hereditary disorder><heritable disorder><in vivo><inborn error><inherited diseases><inherited factor><inherited genetic disease><inherited genetic disorder><insight><late onset alzheimer><life span><lifespan><liquid><microtubule bound tau><microtubule-bound tau><mimetics><necropsy><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurological disease><neuronal><neuropathologic tau><neuropathological tau><novel><older adult><older adulthood><p-tau><p-τ><pathway><peptide mimetic><peptide mimic><peptidomimetics><phase II protocol><phospho-tau><phospho-τ><phosphorylated tau><post-operative delirium><post-translational modification of tau><postmortem><postoperative delirium><posttranslational modification of tau><prevent><preventing><primary degenerative dementia><protein function><resistance to disease><resistant disease><resistant to disease><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><senior citizen><sex><skills><social role><soluble amyloid precursor protein><spinal fluid><surgery><synapse><tangle><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau phosphorylation><tau posttranslational modification><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><thoughts><trait><τ Proteins><τ phosphorylation>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Lei Xie

NORTHEASTERN UNIVERSITY, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$662,161

FY 2026

Project Title

AI-Powered Quantitative Systems Pharmacology for AD Drug Repurposing

Grant Number:

7R01AG057555-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2017

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Alzheimer's disease (AD) poses a triple threat to public health, as its prevalence is on the rise, its costs are immense, and there is no effective therapy. However, drug development attempts for the treatment of AD have met with minimal success. The failure is largely attributable to a red...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Michael Wehr

UNIVERSITY OF OREGON, EUGENE, OR

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$659,684

FY 2026

Project Title

Circuit mechanisms underlying network disruption and temporal processing deficits in Alzheimer's

Grant Number:

5R01AG077681-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract: Despite substantial knowledge of the molecular and genetic mechanisms contributing to amyloid pathology, very little is known about how these molecular mechanisms affect the operation of neural circuits, and how this disrupts neural computation to ultimately produce behavioral deficits in ...

Research Terms

<2-photon><AD biological marker><AD biomarker><AD dementia><AD detection><AD model><AD pathology><AD related biomarker><Address><Affect><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease detection><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's detection><Alzheimer's diagnosis><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease diagnosis><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's pathology><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Appearance><Area><Auditory><Auditory Cortex><Auditory area><Auditory system><Aβ><Behavior><Behavioral><Biological><Biological Markers><Brain region><Cell Death><Chronic><Cognitive deficits><Consensus><Data><Detection><Development><Disease><Disease Progression><Disorder><Early Diagnosis><Electrophysiology><Electrophysiology (science)><Failure><Feedback><Functional MRI><Functional Magnetic Resonance Imaging><Functional impairment><Genetic><Goals><Image><Impairment><Investigation><Knowledge><Measures><Memory Deficit><Memory impairment><Mice><Mice Mammals><Molecular><Motor><Motor Cortex><Murine><Mus><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neuritic Plaques><Neurobiology><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Output><Primary Senile Degenerative Dementia><Pyramidal neuron><Research><Resolution><Rest><Senile Plaques><Sensory><Synapses><Synaptic><Testing><Therapeutic Intervention><Time><a beta peptide><abeta><alzheimer model><amyloid beta><amyloid beta plaque><amyloid pathology><amyloid-b plaque><amyloid-b protein><aβ plaques><behavioral impairment><beta amyloid fibril><bio-markers><biologic><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><cognitive defects><cored plaque><density><developmental><diffuse plaque><early biomarkers><early detection><early detection biomarkers><early detection markers><early onset><electrophysiological><fMRI><hippocampal pyramidal neuron><imaging><impaired behavior><innovate><innovation><innovative><insight><intervention therapy><memory dysfunction><molecular pathology><mouse model><murine model><necrocytosis><neural><neural circuit><neural circuitry><neurobiological><neurocircuitry><neuronal><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><operation><operations><potential biological marker><potential biomarker><primary degenerative dementia><resolutions><senile dementia of the Alzheimer type><sensory cortex><soluble amyloid precursor protein><synapse><synaptic circuit><synaptic circuitry><two-photon>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

LING LI

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$645,802

FY 2026

Project Title

Impact of Mitochondrial Lipidomic Dynamics and its Interaction with APOE Isoforms on Brain Aging and Alzheimers Disease

Grant Number:

5R01AG081426-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The pathogenesis of Alzheimer's disease (AD) remains elusive. Inheritance of the apolipoprotein (APO) E4 allele is the strongest genetic risk factor for sporadic late onset AD, whereas the APOE2 allele is protective and the most common APOE3 allele is neutral. While the mechanisms by...

Research Terms

<3-D Imaging><3D imaging><AD dementia><AD pathology><AD pathway><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><APOE><APOE e3><APOE e4><APOE-ε4><APOEε4><APP-PS1><APP/PS1><Acceleration><Affect><Age><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's pathology><Alzheimer's related pathways><Alzheimers Dementia><Amentia><American><Amyloid deposition><Amyloidosis><Animal Model><Animal Models and Related Studies><Apo-E><ApoE protein><Apolipoprotein E><Astrocytes><Astrocytus><Astroglia><Autopsy><Autoregulation><Axon Terminals><Behavioral><Blood Plasma><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Cell Body><Cell Fractionation><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cell model><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular model><Cerebrum><Clinical><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive Manifestations><Cognitive Symptoms><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Coupled><Data><Dementia><Development><Disturbance in cognition><EC 3.1.1.4><Encephalon><Encephalon Diseases><Energy Expenditure><Energy Metabolism><Evaluation><Family><Genes><Genetic predisposing factor><Genotype><Glia><Glial Cells><Homeostasis><Human><Impaired cognition><Impairment><Individual><Induced pluripotent stem cell derived human neuron><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Isoforms><Knock-in><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Lead><Lecithinase A2><Lipids><Literature><Mediating><Metabolic><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Molecular><Molecular Target><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neuron Degeneration><Neurons><Non-neuronal cell><Nonneuronal cell><Nucleus><Organelles><Organoids><PLA2><Participant><Pathogenesis><Pathogenicity><Pathologic><Pathway interactions><Patients><Pb element><Phospholipase A2><Physiological Homeostasis><Plasma><Plasma Serum><Population><Presynaptic Nerve Endings><Presynaptic Terminals><Prevalence><Primary Senile Degenerative Dementia><Protein Isoforms><Research><Research Specimen><Reticuloendothelial System, Serum, Plasma><Severities><Specimen><Structure><Subcellular Process><Synapses><Synaptic><Synaptic Boutons><Synaptic Terminals><Technology><Testing><Three-Dimensional Imaging><Tissue Sample><Transgenic Organisms><Wild Type Mouse><acylcarnitine><age associated><age correlated><age dependent><age linked><age related><age specific><aged brain><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging brain><aging population><alzheimer risk><amyloid disease><amyloid pathology><apo E-3><apo E-4><apo E3><apo E4><apo epsilon4><apoE epsilon 4><apoE-3><apoE-4><apoE3><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-3><apolipoprotein E-4><apolipoprotein E3><apolipoprotein E4><astrocytic glia><brain tissue><cell type><cerebral><cognitive defects><cognitive dysfunction><cognitive function><cognitive loss><developmental><diagnostic biomarker><diagnostic marker><disease phenotype><genetic risk factor><heavy metal Pb><heavy metal lead><hiPSC-derived neurons><human iPSC-derived sensory neuron><human induced pluripotent stem cell derived sensory neuron><human tissue><iPSC-derived human neuron><inducible pluripotent stem cell derived human neuron><inducible pluripotent stem cell derived human sensory neuron><inherited factor><innovate><innovation><innovative><knockin><late onset alzheimer><lecithinase A><lipidome><lipidomics><mechanisms in AD><mechanisms in Alzheimer's disease><metabolism measurement><metabolomics><metabonomics><mid life><mid-life><middle age><middle aged><midlife><mitochondrial><mitochondrial dysfunction><model of animal><mouse model><multiomics><multiple omics><murine model><necropsy><nerve cement><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuron toxicity><neuronal><neuronal degeneration><neuronal toxicity><neurons differentiated from human induced pluripotent stem cells><neuropathologic><neuropathological><neuropathology><neurotoxicity><novel><old age><panomics><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><phosphatidase><phosphatidolipase><phosphatidylcholine 2 acylhydrolase><population aging><postmortem><primary degenerative dementia><religious order study><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sex><subcellular fractionation><synapse><therapeutic agent development><therapeutic development><transcriptomics><transgenic><wildtype mouse><younger age>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Danni Li

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$645,802

FY 2026

Project Title

Impact of Mitochondrial Lipidomic Dynamics and its Interaction with APOE Isoforms on Brain Aging and Alzheimers Disease

Grant Number:

5R01AG081426-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The pathogenesis of Alzheimer's disease (AD) remains elusive. Inheritance of the apolipoprotein (APO) E4 allele is the strongest genetic risk factor for sporadic late onset AD, whereas the APOE2 allele is protective and the most common APOE3 allele is neutral. While the mechanisms by...

Research Terms

<3-D Imaging><3D imaging><AD dementia><AD pathology><AD pathway><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><APOE><APOE e3><APOE e4><APOE-ε4><APOEε4><APP-PS1><APP/PS1><Acceleration><Affect><Age><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's pathology><Alzheimer's related pathways><Alzheimers Dementia><Amentia><American><Amyloid deposition><Amyloidosis><Animal Model><Animal Models and Related Studies><Apo-E><ApoE protein><Apolipoprotein E><Astrocytes><Astrocytus><Astroglia><Autopsy><Autoregulation><Axon Terminals><Behavioral><Blood Plasma><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Cell Body><Cell Fractionation><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cell model><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular model><Cerebrum><Clinical><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive Manifestations><Cognitive Symptoms><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Coupled><Data><Dementia><Development><Disturbance in cognition><EC 3.1.1.4><Encephalon><Encephalon Diseases><Energy Expenditure><Energy Metabolism><Evaluation><Family><Genes><Genetic predisposing factor><Genotype><Glia><Glial Cells><Homeostasis><Human><Impaired cognition><Impairment><Individual><Induced pluripotent stem cell derived human neuron><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Isoforms><Knock-in><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Lead><Lecithinase A2><Lipids><Literature><Mediating><Metabolic><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Molecular><Molecular Target><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neuron Degeneration><Neurons><Non-neuronal cell><Nonneuronal cell><Nucleus><Organelles><Organoids><PLA2><Participant><Pathogenesis><Pathogenicity><Pathologic><Pathway interactions><Patients><Pb element><Phospholipase A2><Physiological Homeostasis><Plasma><Plasma Serum><Population><Presynaptic Nerve Endings><Presynaptic Terminals><Prevalence><Primary Senile Degenerative Dementia><Protein Isoforms><Research><Research Specimen><Reticuloendothelial System, Serum, Plasma><Severities><Specimen><Structure><Subcellular Process><Synapses><Synaptic><Synaptic Boutons><Synaptic Terminals><Technology><Testing><Three-Dimensional Imaging><Tissue Sample><Transgenic Organisms><Wild Type Mouse><acylcarnitine><age associated><age correlated><age dependent><age linked><age related><age specific><aged brain><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging brain><aging population><alzheimer risk><amyloid disease><amyloid pathology><apo E-3><apo E-4><apo E3><apo E4><apo epsilon4><apoE epsilon 4><apoE-3><apoE-4><apoE3><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-3><apolipoprotein E-4><apolipoprotein E3><apolipoprotein E4><astrocytic glia><brain tissue><cell type><cerebral><cognitive defects><cognitive dysfunction><cognitive function><cognitive loss><developmental><diagnostic biomarker><diagnostic marker><disease phenotype><genetic risk factor><heavy metal Pb><heavy metal lead><hiPSC-derived neurons><human iPSC-derived sensory neuron><human induced pluripotent stem cell derived sensory neuron><human tissue><iPSC-derived human neuron><inducible pluripotent stem cell derived human neuron><inducible pluripotent stem cell derived human sensory neuron><inherited factor><innovate><innovation><innovative><knockin><late onset alzheimer><lecithinase A><lipidome><lipidomics><mechanisms in AD><mechanisms in Alzheimer's disease><metabolism measurement><metabolomics><metabonomics><mid life><mid-life><middle age><middle aged><midlife><mitochondrial><mitochondrial dysfunction><model of animal><mouse model><multiomics><multiple omics><murine model><necropsy><nerve cement><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuron toxicity><neuronal><neuronal degeneration><neuronal toxicity><neurons differentiated from human induced pluripotent stem cells><neuropathologic><neuropathological><neuropathology><neurotoxicity><novel><old age><panomics><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><phosphatidase><phosphatidolipase><phosphatidylcholine 2 acylhydrolase><population aging><postmortem><primary degenerative dementia><religious order study><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sex><subcellular fractionation><synapse><therapeutic agent development><therapeutic development><transcriptomics><transgenic><wildtype mouse><younger age>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Keith A Josephs

MAYO CLINIC ROCHESTER, ROCHESTER, MN

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$643,670

FY 2026

Project Title

The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies

Grant Number:

5R01DC014942-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Progressive apraxia of speech (PAOS) is a devastating neurodegenerative syndrome that ultimately shortens lifespan and is most commonly due to an Alzheimer’s disease related disorders (ADRD) four-repeat tauopathy. Nine years ago, we described two distinct subtypes of PAOS: phonetic P...

Research Terms

<4 repeat tau pathology><4 repeats tauopathies><4R tauopathies><AD and related dementia><AD dementia><AD related dementia><ADRD><Acoustics><Acquired brain injury><Address><Alogia><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Anatomic Sites><Anatomic structures><Anatomy><Anepia><Aphasia><Apraxia><Atrophic><Atrophy><Atypical Parkinson disorder><Autopsy><Biological><Brain><Brain Injuries><Brain Nervous System><Brain Stem><Brain scan><Brainstem><Cerebellum><Characteristics><Clinical><Clinical Trials><Collection><Communication><Corpus Striatum><Corpus striatum structure><Corticodentatonigral degeneration with neuronal achromasia><Cross Sectional Analysis><DWI (diffusion weighted imaging)><DWI-MRI><Data><Data Collection><Deposit><Deposition><Development><Diagnosis><Differential Diagnosis><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Disease><Disease Progression><Disorder><Dysarthosis><Dysarthria><Dyspraxia><Encephalon><Evolution><FDG PET><Fe element><Frequencies><Functional MRI><Functional Magnetic Resonance Imaging><Future><Genetic><Genetic Risk><Genetic predisposing factor><Grant><Haplotypes><Image><Intermediary Metabolism><Intervention><Iron><Knowledge><Language><Language Disorders><Logagnosia><Logamnesia><Logasthenia><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metabolic Processes><Metabolism><Methods><Mutism><NMR Imaging><NMR Tomography><Nerve Degeneration><Neurobiology><Neurologic><Neurological><Neurologist><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Outcome><Parkinson plus syndromes><Pathologic><Pathology><Patient Care><Patient Care Delivery><Patients><Phenotype><Phonetics><Play><Predisposition><Primary Senile Degenerative Dementia><Reporting><Risk-associated variant><Role><Severities><Speech><Speech Disorders><Speech Manifestations><Speech Pathologist><Striate Body><Striatum><Structure><Susceptibility><Syndrome><Tauopathies><Techniques><Time><Zeugmatography><atypical parkinsonian disorder><atypical parkinsonian syndrome><atypical parkinsonism><biologic><brain damage><brain volume><brain-injured><care for patients><care of patients><caring for patients><clinical development><clinical relevance><clinically relevant><cortical basal degeneration><corticobasal degeneration><cost><dMRI><developmental><diffusion tensor imaging><disease prognosis><disease prognostication><experience><fMRI><fluorodeoxyglucose PET><fluorodeoxyglucose positron emission tomography><four repeat tau pathology><four repeat tau tauopathies><four repeats tauopathies><genetic risk factor><imaging><improved><indexing><inherited factor><language deficit><life span><lifespan><metabolic rate><microtubule bound tau><microtubule-bound tau><morphometry><necropsy><nerve cell death><nerve cell loss><neural degeneration><neural imaging><neuro-imaging><neurobiological><neurodegeneration><neurodegenerative><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological degeneration><neurological imaging><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuropathologic><neuropathologic tau><neuropathological><neuropathological tau><neuropathology><novel><postmortem><primary degenerative dementia><prognostic><prospective><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><senile dementia of the Alzheimer type><social role><speech language intervention><speech language pathologist><speech language therapy><speech language treatment><striatal><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><τ Proteins>

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Rene Lynn Utianski

MAYO CLINIC ROCHESTER, ROCHESTER, MN

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$643,670

FY 2026

Project Title

The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies

Grant Number:

5R01DC014942-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Progressive apraxia of speech (PAOS) is a devastating neurodegenerative syndrome that ultimately shortens lifespan and is most commonly due to an Alzheimer’s disease related disorders (ADRD) four-repeat tauopathy. Nine years ago, we described two distinct subtypes of PAOS: phonetic P...

Research Terms

<4 repeat tau pathology><4 repeats tauopathies><4R tauopathies><AD and related dementia><AD dementia><AD related dementia><ADRD><Acoustics><Acquired brain injury><Address><Alogia><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Anatomic Sites><Anatomic structures><Anatomy><Anepia><Aphasia><Apraxia><Atrophic><Atrophy><Atypical Parkinson disorder><Autopsy><Biological><Brain><Brain Injuries><Brain Nervous System><Brain Stem><Brain scan><Brainstem><Cerebellum><Characteristics><Clinical><Clinical Trials><Collection><Communication><Corpus Striatum><Corpus striatum structure><Corticodentatonigral degeneration with neuronal achromasia><Cross Sectional Analysis><DWI (diffusion weighted imaging)><DWI-MRI><Data><Data Collection><Deposit><Deposition><Development><Diagnosis><Differential Diagnosis><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Disease><Disease Progression><Disorder><Dysarthosis><Dysarthria><Dyspraxia><Encephalon><Evolution><FDG PET><Fe element><Frequencies><Functional MRI><Functional Magnetic Resonance Imaging><Future><Genetic><Genetic Risk><Genetic predisposing factor><Grant><Haplotypes><Image><Intermediary Metabolism><Intervention><Iron><Knowledge><Language><Language Disorders><Logagnosia><Logamnesia><Logasthenia><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metabolic Processes><Metabolism><Methods><Mutism><NMR Imaging><NMR Tomography><Nerve Degeneration><Neurobiology><Neurologic><Neurological><Neurologist><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Outcome><Parkinson plus syndromes><Pathologic><Pathology><Patient Care><Patient Care Delivery><Patients><Phenotype><Phonetics><Play><Predisposition><Primary Senile Degenerative Dementia><Reporting><Risk-associated variant><Role><Severities><Speech><Speech Disorders><Speech Manifestations><Speech Pathologist><Striate Body><Striatum><Structure><Susceptibility><Syndrome><Tauopathies><Techniques><Time><Zeugmatography><atypical parkinsonian disorder><atypical parkinsonian syndrome><atypical parkinsonism><biologic><brain damage><brain volume><brain-injured><care for patients><care of patients><caring for patients><clinical development><clinical relevance><clinically relevant><cortical basal degeneration><corticobasal degeneration><cost><dMRI><developmental><diffusion tensor imaging><disease prognosis><disease prognostication><experience><fMRI><fluorodeoxyglucose PET><fluorodeoxyglucose positron emission tomography><four repeat tau pathology><four repeat tau tauopathies><four repeats tauopathies><genetic risk factor><imaging><improved><indexing><inherited factor><language deficit><life span><lifespan><metabolic rate><microtubule bound tau><microtubule-bound tau><morphometry><necropsy><nerve cell death><nerve cell loss><neural degeneration><neural imaging><neuro-imaging><neurobiological><neurodegeneration><neurodegenerative><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological degeneration><neurological imaging><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuropathologic><neuropathologic tau><neuropathological><neuropathological tau><neuropathology><novel><postmortem><primary degenerative dementia><prognostic><prospective><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><senile dementia of the Alzheimer type><social role><speech language intervention><speech language pathologist><speech language therapy><speech language treatment><striatal><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><τ Proteins>

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Sarah Cohen

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$571,695

FY 2026

Project Title

Assessing the role of APOE in glial lipid droplet metabolism and function

Grant Number:

5R01AG081421-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Alzheimer’s disease (AD) is one of the predominant causes of disability and dependency among older people, and the sixth leading cause of death in the United States. Late-onset AD is the most common form, with more than 99% of AD cases occurring after age 65. The strongest genetic risk fact...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><APOE><APOE e4><APOE-ε4><APOEε4><Affect><Age><Aged 65 and Over><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Amyloidosis><Apo-E><ApoE protein><Apolipoprotein E><Area><Astrocytes><Astrocytus><Astroglia><Autoregulation><Brain><Brain Nervous System><Brain region><CNS Nervous System><Cause of Death><Cell Death><Cellular biology><Central Nervous System><Code><Coding System><Communities><Cytoplasm><Data><Data Bases><Data Set><Databases><Dementia><Dependence><Deposit><Deposition><Drug Targeting><Educational workshop><Effector Cell><Encephalon><Endoplasmic Reticulum><Ergastoplasm><Fluorescence Activated Cell Sorting Fractionation><Fluorescence-Activated Cell Sorting><Fluorescence-Activated Cell Sortings><Future><Genetic predisposing factor><Genotype><Glia><Glial Cells><Glycolysis><Homeostasis><Hortega cell><Image><Immune><Immunes><Inflammation><Inflammatory><Innate Immunity><Intermediary Metabolism><Investigation><Isoforms><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Lipid Peroxidation><Lipid Trafficking><Lipids><Lipoproteins><Metabolic Processes><Metabolism><Mice><Mice Mammals><Microglia><Microscopy><Molecular><Murine><Mus><Native Immunity><Natural Immunity><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System><Neural Cell><Neuraxis><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic Body System><Neurologic Organ System><Neuron Degeneration><Neurons><Non-Specific Immunity><Non-neuronal cell><Nonneuronal cell><Nonspecific Immunity><Null Mouse><Older Population><Pathway interactions><Physiological Homeostasis><Play><Primary Senile Degenerative Dementia><Protein Isoforms><Proteins><Research><Research Resources><Resources><Risk><Role><Surface><Testing><Therapeutic><United States><Visualization><Work><Workshop><above age 65><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged brain><aged ≥65><ages><aging brain><alzheimer risk><amyloid disease><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><astrocytic glia><brain cell><cell biology><cell type><cytokine><data base><disability><fat metabolism><genetic risk factor><gitter cell><human old age (65+)><imaging><in vivo><inherited factor><insight><lab experience><lab training><laboratory experience><laboratory training><late onset alzheimer><lipid metabolism><lipid transport><mesoglia><microglial cell><microgliocyte><mouse model><murine model><natural aging><necrocytosis><nerve cement><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal><neuronal degeneration><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><normal aging><normative aging><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><older groups><older individuals><older person><over 65 years><particle><pathway><perivascular glial cell><prevent><preventing><primary degenerative dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social role><trafficking><≥65 years>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Lance Allen Johnson

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$571,695

FY 2026

Project Title

Assessing the role of APOE in glial lipid droplet metabolism and function

Grant Number:

5R01AG081421-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Alzheimer’s disease (AD) is one of the predominant causes of disability and dependency among older people, and the sixth leading cause of death in the United States. Late-onset AD is the most common form, with more than 99% of AD cases occurring after age 65. The strongest genetic risk fact...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><APOE><APOE e4><APOE-ε4><APOEε4><Affect><Age><Aged 65 and Over><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Amyloidosis><Apo-E><ApoE protein><Apolipoprotein E><Area><Astrocytes><Astrocytus><Astroglia><Autoregulation><Brain><Brain Nervous System><Brain region><CNS Nervous System><Cause of Death><Cell Death><Cellular biology><Central Nervous System><Code><Coding System><Communities><Cytoplasm><Data><Data Bases><Data Set><Databases><Dementia><Dependence><Deposit><Deposition><Drug Targeting><Educational workshop><Effector Cell><Encephalon><Endoplasmic Reticulum><Ergastoplasm><Fluorescence Activated Cell Sorting Fractionation><Fluorescence-Activated Cell Sorting><Fluorescence-Activated Cell Sortings><Future><Genetic predisposing factor><Genotype><Glia><Glial Cells><Glycolysis><Homeostasis><Hortega cell><Image><Immune><Immunes><Inflammation><Inflammatory><Innate Immunity><Intermediary Metabolism><Investigation><Isoforms><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Lipid Peroxidation><Lipid Trafficking><Lipids><Lipoproteins><Metabolic Processes><Metabolism><Mice><Mice Mammals><Microglia><Microscopy><Molecular><Murine><Mus><Native Immunity><Natural Immunity><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System><Neural Cell><Neuraxis><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic Body System><Neurologic Organ System><Neuron Degeneration><Neurons><Non-Specific Immunity><Non-neuronal cell><Nonneuronal cell><Nonspecific Immunity><Null Mouse><Older Population><Pathway interactions><Physiological Homeostasis><Play><Primary Senile Degenerative Dementia><Protein Isoforms><Proteins><Research><Research Resources><Resources><Risk><Role><Surface><Testing><Therapeutic><United States><Visualization><Work><Workshop><above age 65><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged brain><aged ≥65><ages><aging brain><alzheimer risk><amyloid disease><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><astrocytic glia><brain cell><cell biology><cell type><cytokine><data base><disability><fat metabolism><genetic risk factor><gitter cell><human old age (65+)><imaging><in vivo><inherited factor><insight><lab experience><lab training><laboratory experience><laboratory training><late onset alzheimer><lipid metabolism><lipid transport><mesoglia><microglial cell><microgliocyte><mouse model><murine model><natural aging><necrocytosis><nerve cement><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal><neuronal degeneration><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><normal aging><normative aging><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><older groups><older individuals><older person><over 65 years><particle><pathway><perivascular glial cell><prevent><preventing><primary degenerative dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social role><trafficking><≥65 years>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

PATRICIA M KANE

UPSTATE MEDICAL UNIVERSITY, SYRACUSE, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$570,500

FY 2026

Project Title

Regulation and Cellular Functions of V-ATPases

Grant Number:

5R35GM145256-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY V-ATPases are versatile, highly conserved, multi-subunit proton pumps responsible for organelle acidification in virtually all eukaryotic cells. Complete loss of V-ATPase activity is lethal in all eukaryotes except fungi, but mutations in subunit isoforms are linked to distal renal t...

Research Terms

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Shaojie Zhang

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Recent

Active award

$556,359

FY 2026

Project Title

PG4AD: Scaling up pangenome graph for genotyping complex structural variations for Alzheimer's disease genetics

Grant Number:

1U01AG098387-01

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT The Human Pangenome Reference Consortium (HPRC) has built a tremendously valuable resource of high- quality human pangenome reference assemblies of individuals and their corresponding pangenome graph that greatly reduced reference biases. However, uptake and utilization of t...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Degui Zhi

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Recent

Active award

$556,359

FY 2026

Project Title

PG4AD: Scaling up pangenome graph for genotyping complex structural variations for Alzheimer's disease genetics

Grant Number:

1U01AG098387-01

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT The Human Pangenome Reference Consortium (HPRC) has built a tremendously valuable resource of high- quality human pangenome reference assemblies of individuals and their corresponding pangenome graph that greatly reduced reference biases. However, uptake and utilization of t...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Marco Matthias Hefti

UNIVERSITY OF IOWA, IOWA CITY, IA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$555,197

FY 2026

Project Title

A non-canonical role for tau in early human brain development

Grant Number:

5R01NS136448-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Although best known for its role in Alzheimer disease, the tau protein is a significant driver of neuronal network dysfunction in neurodevelopmental disorders, including epilepsy and autism, which have a devastating lifelong impact on function and quality of life. Tau phosphorylation, detachment fro...

Research Terms

<21+ years old><AD dementia><ASD><Acquired brain injury><Adult><Adult Human><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Autism><Autistic Disorder><Axon><Binding><Biologic Models><Biological Models><Brain><Brain Injuries><Brain Nervous System><Cell Line><CellLine><Data><Dendrites><Development><Disease><Disorder><Drugs><Early Infantile Autism><Encephalon><Ensure><Epilepsy><Epileptic Seizures><Epileptics><FYN Protein><Goals><Human><Impairment><In Vitro><Infantile Autism><KI mice><Kanner's Syndrome><Kinases><Knock-in Mouse><Knock-out><Knockout><Knowledge><Life><Literature><MT-bound tau><Medication><Mice><Mice Mammals><Micro-tubule><Microtubules><Model System><Modern Man><Molecular Interaction><Murine><Mus><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><NMDA Receptor-Ionophore Complex><NMDA Receptors><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Outcome><Pathology><Pathway interactions><Pharmaceutical Preparations><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiological><Primary Senile Degenerative Dementia><Process><Protein Phosphorylation><Proto-Oncogene Proteins c-fyn><Publishing><QOL><Quality of life><Receptor Signaling><Reducing Agents><Reductants><Rodent><Rodentia><Rodents Mammals><Role><Safety><Seizure Disorder><Strains Cell Lines><Stress><Structure><Synapses><Synaptic><Testing><Therapeutic><Toxic effect><Toxicities><Translating><Transphosphorylases><Upregulation><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><brain damage><brain-injured><c-fyn protein><cultured cell line><developmental><drug/agent><epilepsia><epileptogenic><experiment><experimental research><experimental study><experiments><fetal><fyn tyrosine kinase><gain of function><human fetal brain><human model><human progenitor><human progenitor cell derived><human stem cell-derived><human stem cells><hypoxic ischemic injury><knockin mice><microtubule bound tau><microtubule-bound tau><model of human><network dysfunction><neurodevelopment><neurodevelopmental disease><neuron toxicity><neuronal><neuronal toxicity><neurotoxicity><p-tau><p-τ><pathway><phospho-tau><phospho-τ><phosphorylated tau><post-translational modification of tau><postnatal><posttranslational modification of tau><primary degenerative dementia><protein function><proto-oncogene protein c-syn><senile dementia of the Alzheimer type><social role><synapse><targeted agent><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau factor><tau function><tau phosphorylation><tau posttranslational modification><tau-1><therapeutic target><τ Proteins><τ function><τ phosphorylation>

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JEANNE Bentley LAWRENCE

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$535,709

FY 2026

Project Title

A Novel Approach to Molecular Cell Pathologies of Human Down Syndrome and DS-AD

Grant Number:

4R01HD091357-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/12/2017

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Down Syndrome (DS), or Trisomy 21 (T21), is a highly common cause of cognitive disability in children, and also impacts individuals throughout life, by increased risks of congenital heart disease, viral susceptibility, leukemia, and conditions such as metabolic, autoimmune and autism spectr...

Research Terms

<0-11 years old><21+ years old><AD dementia><AD model><ADAM10 protein><ASD><Aberrant Chromosome><Address><Adult><Adult Human><Affect><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimers Dementia><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Autism><Autistic Disorder><Autoimmune><Aβ><Body Tissues><Brain><Brain Nervous System><Cardiac Malformation><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Child><Child Youth><Children (0-21)><Chromosomal Aberrations><Chromosomal Abnormalities><Chromosomal Alterations><Chromosomal Amplification><Chromosomal Duplication><Chromosome 21><Chromosome Aberrations><Chromosome Alterations><Chromosome Anomalies><Chromosome abnormality><Chromosomes><Cilia><Cognitive deficits><Cytogenetic Aberrations><Cytogenetic Abnormalities><Development><Disease><Disorder><Down Syndrome><Drug Targeting><EOAD><Early Infantile Autism><Early Onset Alzheimer Disease><Encephalon><Endothelial Cells><Equilibrium><Functional RNA><Funding><Gene Cluster><Gene Expression><Genes><Genetic><Genome><Heart Malformation><Hematopoietic><Human><Human Pathology><In Vitro><Individual><Individuals with down syndrome><Infantile Autism><Intracellular Communication and Signaling><Kanner's Syndrome><Knowledge><Langdon Down syndrome><Life><Medical><Metabolic><Methods><Modeling><Modern Man><Molecular><Mongolism><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuron Degeneration><Neurons><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Organoids><Pathogenesis><Pathology><Pathway interactions><Persons><Phenotype><Population><Post-Transcriptional Gene Silencing><Predisposition><Premature Aging><Premature aging syndrome><Primary Senile Degenerative Dementia><Progenitor Cells><RNA><RNA Gene Products><RNA Interference><RNA Seq><RNA Silencing><RNA sequencing><RNAi><RNAseq><Repression><Research Resources><Resources><Ribonucleic Acid><Risk><Role><Sequence-Specific Posttranscriptional Gene Silencing><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Susceptibility><System><Testing><Therapeutic><Tissues><Trisomy><Trisomy 21><Untranslated RNA><Variant><Variation><Vascular System><Viral><Viral Diseases><Virus Diseases><Work><a beta peptide><abeta><abnormal heart development><adulthood><alzheimer model><amyloid beta><amyloid-b protein><angiogenesis><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><balance><balance function><beta amyloid fibril><biological signal transduction><cell type><cellular differentiation><chromosomal defect><chromosome 21 trisomy><chromosome 21 trisomy syndrome><chromosome defect><cognitive defects><cognitive disability><cognitively disabled><congenital acromicria syndrome><congenital cardiac abnormality><congenital cardiac anomalies><congenital cardiac disease><congenital cardiac disorder><congenital cardiac malformation><congenital heart abnormality><congenital heart anomaly><congenital heart disease><congenital heart disorder><congenital heart malformation><developmental><dosage><down syndrome individuals><down syndrome patients><drug development><early onset AD><early onset Alzheimer's><expectation><gamma secretase><gamma secretase complex><genome scale><genome-wide><genomewide><hemopoietic><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><kids><leukemia><morbus Down><neural degeneration><neurodegeneration><neurodegenerative><neurogenesis><neurological degeneration><neuronal><neuronal degeneration><new approaches><noncoding><novel><novel approaches><novel strategies><novel strategy><overexpress><overexpression><pathway><patients with down syndrome><people with down syndrome><primary degenerative dementia><pseudohypertrophic progressive muscular dystrophy><response><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><soluble amyloid precursor protein><stem cells><tool><transcriptome sequencing><transcriptomic sequencing><transcriptomics><trisomy 21 syndrome><viral infection><virus infection><virus-induced disease><youngster><γ-secretase>

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Stephanie Anne-Carine Debette

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,267,462

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

2R01AG059421-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Carole Dufouil

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,267,462

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

2R01AG059421-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

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Mohammad Arfan Ikram

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,267,462

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

2R01AG059421-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Claudia L Satizabal

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,267,462

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

2R01AG059421-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

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Sudha Seshadri

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,267,462

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

2R01AG059421-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

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Astrid M Suchy-Dicey

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,267,462

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

2R01AG059421-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

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Brian William Kunkle

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, CORAL GABLES, FL

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,232,914

FY 2026

Project Title

Integrative Analysis to Understand the Contribution of the X Chromosome to Alzheimer's Disease

Grant Number:

1RF1AG099026-01

Activity Code:

RF1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT The X chromosome constitutes about ~5% of the human genome and harbors approximately 800 protein-coding genes, many of which have important immune and brain-related functions. Recently, we and others have demonstrated that the X chromosome is involved in Alzheimer’s disease (AD) risk. Howev...

Research Terms

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Eden R. Martin

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, CORAL GABLES, FL

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,232,914

FY 2026

Project Title

Integrative Analysis to Understand the Contribution of the X Chromosome to Alzheimer's Disease

Grant Number:

1RF1AG099026-01

Activity Code:

RF1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT The X chromosome constitutes about ~5% of the human genome and harbors approximately 800 protein-coding genes, many of which have important immune and brain-related functions. Recently, we and others have demonstrated that the X chromosome is involved in Alzheimer’s disease (AD) risk. Howev...

Research Terms

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Lily Wang

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, CORAL GABLES, FL

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,232,914

FY 2026

Project Title

Integrative Analysis to Understand the Contribution of the X Chromosome to Alzheimer's Disease

Grant Number:

1RF1AG099026-01

Activity Code:

RF1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT The X chromosome constitutes about ~5% of the human genome and harbors approximately 800 protein-coding genes, many of which have important immune and brain-related functions. Recently, we and others have demonstrated that the X chromosome is involved in Alzheimer’s disease (AD) risk. Howev...

Research Terms

View Full Project Details on NIH Reporter

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Juan Isaac Young

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, CORAL GABLES, FL

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,232,914

FY 2026

Project Title

Integrative Analysis to Understand the Contribution of the X Chromosome to Alzheimer's Disease

Grant Number:

1RF1AG099026-01

Activity Code:

RF1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT The X chromosome constitutes about ~5% of the human genome and harbors approximately 800 protein-coding genes, many of which have important immune and brain-related functions. Recently, we and others have demonstrated that the X chromosome is involved in Alzheimer’s disease (AD) risk. Howev...

Research Terms

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Sarah Ann Flowers

WINIFRED MASTERSON BURKE MED RES INST, WHITE PLAINS, NY

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,557,123

FY 2026

Project Title

Mechanistic links between the benefits of pharmacologically high thiamine (vitamin B1) in Alzheimer's disease to Advanced Glycation Endproducts (AGE)

Grant Number:

5R01AG082228-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Experimental data linking thiamine (vitamin B1) deficiency to Alzheimer’s disease (AD) inspired our clinical trial, which generated preliminary evidence that pharmacological thiamine produced by the drug benfotiamine provides clinical benefit. We hypothesize that pharmacological thiamine is protecti...

Research Terms

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GARY E GIBSON

WINIFRED MASTERSON BURKE MED RES INST, WHITE PLAINS, NY

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,557,123

FY 2026

Project Title

Mechanistic links between the benefits of pharmacologically high thiamine (vitamin B1) in Alzheimer's disease to Advanced Glycation Endproducts (AGE)

Grant Number:

5R01AG082228-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Experimental data linking thiamine (vitamin B1) deficiency to Alzheimer’s disease (AD) inspired our clinical trial, which generated preliminary evidence that pharmacological thiamine produced by the drug benfotiamine provides clinical benefit. We hypothesize that pharmacological thiamine is protecti...

Research Terms

View Full Project Details on NIH Reporter

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Sheng Zhang

WINIFRED MASTERSON BURKE MED RES INST, WHITE PLAINS, NY

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,557,123

FY 2026

Project Title

Mechanistic links between the benefits of pharmacologically high thiamine (vitamin B1) in Alzheimer's disease to Advanced Glycation Endproducts (AGE)

Grant Number:

5R01AG082228-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Experimental data linking thiamine (vitamin B1) deficiency to Alzheimer’s disease (AD) inspired our clinical trial, which generated preliminary evidence that pharmacological thiamine produced by the drug benfotiamine provides clinical benefit. We hypothesize that pharmacological thiamine is protecti...

Research Terms

View Full Project Details on NIH Reporter

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HONG YU

UNIVERSITY OF MASSACHUSETTS LOWELL, LOWELL, MA

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,477,571

FY 2026

Project Title

Social and behavioral determinants of health and Alzheimer’s Disease: Cohort study of the US military veteran population

Grant Number:

5R01AG080670-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Social and behavioral determinants of health and Alzheimer’s Disease: Cohort study of the US military veteran population Alzheimer’s Disease (AD) affects an estimated 5.8 million US adults. Veterans are particularly susceptible to AD due to demographic, clinical, and economic factors. Social determ...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD dementia><AD prevention><AD risk><AD risk factor><AD therapy><AD treatment><Address><Adult><Adult Human><Affect><Age><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease prevention><Alzheimer disease treatment><Alzheimer prevention><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's diagnosis><Alzheimer's disease diagnosis><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's therapy><Alzheimers Dementia><Amentia><Behavioral><Black American><Brain Trauma><Cause of Death><Clinic><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cohort Studies><Data><Dementia><Development><Diagnostic Findings><Disturbance in cognition><Dose><Early Diagnosis><Economic Factors><Economical Factors><Electronic Health Record><Ethnic Origin><Ethnicity><Exposure to><Financial Hardship><Generations><Health><Health Care><Health Care Costs><Health Care Systems><Health Costs><Health Surveys><High Prevalence><Homelessness><Impaired cognition><Incidence><Informatics><Infrastructure><Integrated Health Care Systems><Intervention><Investigators><Job loss><Learning><Machine Learning><Maintenance><Measures><Mental Health><Mental Hygiene><Modeling><Natural Language Processing><Neurology><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Observational research><Outcome><PTSD><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Persons><Population><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Predisposition><Primary Care><Primary Senile Degenerative Dementia><Process><Psychological Health><Public Policy><Race><Races><Regression Analyses><Regression Analysis><Regression Diagnostics><Reporting><Research><Research Personnel><Research Resources><Researchers><Resources><Retrieval><Risk><Risk Reduction><Secure><Signs and Symptoms><Smoking><Social Service><Social Work><Social isolation><Statistical Regression><Stress><Structure><Susceptibility><System><Time><Traumatic Brain Injury><United States Department of Veterans Affairs><United States Veterans Administration><Update><Veterans><Veterans Administration><Veterans Affairs><Veterans Health Administration><Veterans Health Affairs><Vulnerable Populations><Woman><Work><above age 65><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><ages><alzheimer risk><behavioral health><case control><case-controlled><cognitive dysfunction><cognitive loss><cohort research study><cohort survey><computer based prediction><cost><cost effective><deep learning based model><deep learning model><dementia risk><design><designing><developmental><digital repositories><early detection><economic hardship><economic strain><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><electronic repositories><electronic structure><ethnic minority><experience><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><food insecure><food insecurity><food scarcity><health determinants><high risk group><high risk individual><high risk people><high risk population><homeless><houselessness><human old age (65+)><improved><innovate><innovation><innovative><integrated health system><integrated system of care><intersectionalities><intersectionality><investigate observational><low food security><machine based learning><malleable risk><men><military veteran><modifiable risk><natural language understanding><observational investigation><older adult><older adulthood><opiate overdose><opiate related overdose><opioid drug overdose><opioid induced overdose><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><over 65 years><patient oriented outcomes><population health><post-trauma stress disorder><posttrauma stress disorder><predictive modeling><prevent><preventing><primary degenerative dementia><racial><racial background><racial minority><racial origin><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><risk-reducing><senile dementia of the Alzheimer type><sex><social><social health determinants><structured data><study observational><substance use><substance using><survey observational><traumatic brain damage><traumatic neurosis><unhoused><veteran population><virtual><vulnerable group><vulnerable individual><vulnerable people><≥65 years>

View Full Project Details on NIH Reporter

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William S Bush

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,256,627

FY 2026

Project Title

Alzheimer Disease Genetic Analysis to Identify Potential Therapeutic Targets (ADAPTT)

Grant Number:

1R01AG096172-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Alzheimer disease (AD) is the fifth most frequent cause of death in the U.S. and currently affects nearly 55 million individuals of all ancestries worldwide; this number is predicted to double over the next 20 years. Clinical trials for effective therapeutics have almost all failed, and the few curr...

Research Terms

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Jonathan L Haines

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,256,627

FY 2026

Project Title

Alzheimer Disease Genetic Analysis to Identify Potential Therapeutic Targets (ADAPTT)

Grant Number:

1R01AG096172-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Alzheimer disease (AD) is the fifth most frequent cause of death in the U.S. and currently affects nearly 55 million individuals of all ancestries worldwide; this number is predicted to double over the next 20 years. Clinical trials for effective therapeutics have almost all failed, and the few curr...

Research Terms

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Eden R. Martin

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,256,627

FY 2026

Project Title

Alzheimer Disease Genetic Analysis to Identify Potential Therapeutic Targets (ADAPTT)

Grant Number:

1R01AG096172-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Alzheimer disease (AD) is the fifth most frequent cause of death in the U.S. and currently affects nearly 55 million individuals of all ancestries worldwide; this number is predicted to double over the next 20 years. Clinical trials for effective therapeutics have almost all failed, and the few curr...

Research Terms

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Margaret A. Pericak-Vance

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,256,627

FY 2026

Project Title

Alzheimer Disease Genetic Analysis to Identify Potential Therapeutic Targets (ADAPTT)

Grant Number:

1R01AG096172-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Alzheimer disease (AD) is the fifth most frequent cause of death in the U.S. and currently affects nearly 55 million individuals of all ancestries worldwide; this number is predicted to double over the next 20 years. Clinical trials for effective therapeutics have almost all failed, and the few curr...

Research Terms

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JEFFERY Marvin VANCE

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,256,627

FY 2026

Project Title

Alzheimer Disease Genetic Analysis to Identify Potential Therapeutic Targets (ADAPTT)

Grant Number:

1R01AG096172-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Alzheimer disease (AD) is the fifth most frequent cause of death in the U.S. and currently affects nearly 55 million individuals of all ancestries worldwide; this number is predicted to double over the next 20 years. Clinical trials for effective therapeutics have almost all failed, and the few curr...

Research Terms

View Full Project Details on NIH Reporter

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Kristine Yaffe

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Large award

Active award

$1,348,156

FY 2026

Project Title

Lifecourse Predictors and Mechanisms of Early Clinical ADRD among Black and White Adults in their Sixties

Grant Number:

5R01AG091431-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT The physiologic and neuropathologic processes in Alzheimer disease (AD) and Alzheimer disease related disorders (ADRD) are insidious and take decades to develop. Furthermore, the likelihood of developing AD/ADRD is influenced by the interplay of genetics and risk/resilience factors, especia...

Research Terms

<21+ years old><AD and related dementia><AD biological marker><AD biomarker><AD dementia><AD model><AD related biomarker><AD related dementia><ADRD><Acceleration><Address><Adult><Adult Human><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's biomarker><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease model><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related biomarker><Alzheimer's disease related dementia><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Apoplexy><Assay><Bioassay><Biological Assay><Biological Markers><Black><Black race><Blood><Blood Reticuloendothelial System><Blood Vessels><Brain><Brain Nervous System><Brain Vascular Accident><Cardiovascular Diseases><Care Givers><Caregivers><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Climacteric><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Coronary Artery Risk Development in Young Adults><Coronary Artery Risk Development in Young Adults Study><Data Element><Dementia><Development><Disease><Disorder><Disparities><Disparity><Disturbance in cognition><Early Diagnosis><Encephalon><Enrollment><Equilibrium><Exposure Assessment><Exposure to><Family><Future><Genetic><Genetic Risk><History><Hypertension><Impaired cognition><Incidence><Investigation><Life><Life Cycle><Life Cycle Stages><Link><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Mediating><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Modeling><NMR Imaging><NMR Tomography><Nerve Degeneration><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Outcome><Participant><Pathway interactions><Patients><Pattern><Persons><Phase><Physiologic><Physiological><Population Heterogeneity><Position><Positioning Attribute><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Primary Prevention><Primary Senile Degenerative Dementia><Probability><Process><Race><Races><Recording of previous events><Risk><Risk Factors><Sleep><Societies><Stroke><Time><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Work><Zeugmatography><accumulated exposure><accumulated long-term exposure><adjudication><adjudicative process and procedure><adulthood><ages><aggregate exposure><alzheimer model><balance><balance function><bi-racial><bio-markers><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><biracial><black male><black man><black men><brain MR imaging><brain MRI><brain attack><brain health><brain magnetic resonance imaging><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><cerebral vascular accident><cerebrovascular accident><cognitive assessment><cognitive change><cognitive dysfunction><cognitive loss><cognitive testing><cohort><computer based prediction><cumulative exposure><cumulative life exposure><cumulative long-term exposure><developmental><differences due to race><differences in race><differs by race><differs in race><disease prevention><disorder prevention><disparity in health><diverse populations><drug development><early detection><enroll><experience><exposure analysis><exposure evaluation><exposure measurement><exposure profiling><exposure survey><health disparity><heterogeneous population><high blood pressure><histories><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><innovate><innovation><innovative><insight><investigate prospective><late in life><late life><life change><life course><life-course exposure><lifelong exposure><lifespan exposure><lifetime exposure><male><mid life><mid-life><middle age><middle aged><midlife><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><neuropathologic><neuropathological><neuropathology><novel><pathway><polygenetic risk scores><polygenic risk score><population based><population diversity><predictive modeling><prevent><preventing><primary degenerative dementia><prognosis model><prognostic model><prognostication><prospective><prospective investigation><prospective research><race based differences><race differences><race related differences><racial><racial background><racial difference><racial origin><racially different><resilience factor><resiliency factor><senile dementia of the Alzheimer type><sex><social health determinants><social influence><stroked><strokes><study prospective><survey prospective><synergism><totality of exposures><vascular><♂>

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DAVID EISENBERG

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 66/100

Likely hiring

Large award

Active award

$1,192,535

FY 2026

Project Title

Towards Treatment of Alzheimer’s Disease by Targeting Pathogenic Tau and Beta-Amyloid Structures

Grant Number:

5R01AG070895-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary Aim 1 addresses the dearth of drugs for dementia, by structure-based drug design. This approach, so fruitful for treating cancer and HIV-AIDS, is opening for Alzheimer’s Disease (AD) because of advances in diffraction and cryoEM. Aggregation of protein Tau is strongly correlated with...

Research Terms

<3-D><3-Dimensional><3D><AD brain><AD dementia><AD model><AD patients><AD therapy><AD treatment><AIDS/HIV><Address><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease patient><Alzheimer's disease test><Alzheimer's disease therapy><Alzheimer's patient><Alzheimer's test><Alzheimer's therapy><Alzheimers Dementia><Amentia><American><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β oligomer><Amyloid β-Peptide><Amyloid β-Protein><Amyloidosis><Antibodies><Autopsy><Aβ><AβO><Brain><Brain Nervous System><Cancers><Causality><Cell Body><Cells><Collaborations><Complex><Cryo-electron Microscopy><Cryoelectron Microscopy><Data Collection><Dementia><Development><Disease><Disorder><Drug Binding Site><Drug Design><Drugs><EGCG><EGCG cpd><Electron Cryomicroscopy><Electron Microscopy><Encephalon><Epigallocatechin Gallate><Etiology><Exhibits><Frustration><Green Tea Extract><Green Tea Polyphenols><HIV/AIDS><Human><Investigators><Knowledge><Learning><Ligands><MT-bound tau><Malignant Neoplasms><Malignant Tumor><Medication><Mice><Mice Mammals><Modern Man><Murine><Mus><Nature><Negative Staining><Nerve Degeneration><Neuron Degeneration><Organoids><Pharmaceutical Preparations><Primary Senile Degenerative Dementia><Property><Proteins><Research Personnel><Researchers><Resolution><Science><Structure><Tau forming aggregates><Tauopathies><Tea catechin><Testing><Vacuum><Work><X ray diffraction><X ray diffraction analysis><Xray diffraction><a beta peptide><aberrant tau><aberrant tau protein><abeta><abeta oligomer><abnormal tau><abnormal tau protein><abnormally aggregated tau protein><aggregation in tau><alzheimer model><amyloid beta><amyloid beta oligomer><amyloid disease><amyloid structure><amyloid-b protein><aβ oligomer><beta amyloid fibril><brain behavior><causation><cell type><cryo-EM><cryoEM><cryogenic electron microscopy><cytotoxic><design><designing><determine efficacy><developmental><disease causation><drug candidate><drug detection><drug testing><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electrical property><epigallocatechin-3-gallate><evaluate efficacy><examine efficacy><filamentous tau inclusion><frontier><improved><inhibitor><malignancy><microtubule associated protein tau aggregation><microtubule associated protein tau deposit><microtubule associated protein tau mutation><microtubule bound tau><microtubule-associated protein tau mutation><microtubule-bound tau><mouse model><murine model><mutant tau><mutant tau protein><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><nano particle><nano-sized particle><nanoparticle><nanosized particle><necropsy><neoplasm/cancer><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><neuropathologic tau><neuropathological tau><oAβ><oligomeric amyloid beta><oligomeric amyloid-β><paired helical filament of tau><pathogenic tau><pathogenic tau gene mutation><pathogenic tau protein><pathological change in tau><pathological tau><pathological tau protein><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><pharmacophore><postmortem><primary degenerative dementia><reconstruction><resolutions><screening><screenings><self-aggregate tau><senile dementia of the Alzheimer type><soluble amyloid precursor protein><tau><tau PHF><tau Proteins><tau abnormality><tau accumulation><tau aggregate><tau aggregation><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau fibrillation><tau fibrillization><tau filament><tau inclusion><tau induced degeneration><tau induced neurodegeneration><tau intronic mutation><tau mediated neurodegeneration><tau mutation><tau neurodegenerative disease><tau neurofibrillary tangle><tau neuropathology><tau oligomer><tau paired helical filament><tau pathological change><tau pathology><tau pathophysiology><tau polymerization><tau protein accumulation><tau protein aggregation><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tau-tau interaction><tauopathic neurodegenerative disorder><tauopathy><test for Alzheimer><three dimensional><tool><τ Proteins><τ aggregation><τ mutation>

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Oleg Butovsky

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$829,912

FY 2026

Project Title

Role of a novel risk loci HAVCR2 of late-onset Alzheimer's disease in the regulation of microglial response in neurodegeneration

Grant Number:

5R01AG080992-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Recent largest GWAS identified HAVCR2 (TIM3) genetic risk factor for late-onset Alzheimer’s disease (LOAD). Our laboratory discovered and cloned Tim3 as an inhibitory molecule that induces T cell exhaustion in cancer1. Blocking antibodies to Tim3 are being approved for the treatment ...

Research Terms

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VIJAY K. KUCHROO

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$829,912

FY 2026

Project Title

Role of a novel risk loci HAVCR2 of late-onset Alzheimer's disease in the regulation of microglial response in neurodegeneration

Grant Number:

5R01AG080992-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Recent largest GWAS identified HAVCR2 (TIM3) genetic risk factor for late-onset Alzheimer’s disease (LOAD). Our laboratory discovered and cloned Tim3 as an inhibitory molecule that induces T cell exhaustion in cancer1. Blocking antibodies to Tim3 are being approved for the treatment ...

Research Terms

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Jun Li

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$827,317

FY 2026

Project Title

Identification of brain metabolomic profiles associated with dementia

Grant Number:

5R01AG087356-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ ABSTRACT Identifying mechanistic pathways underlying Alzheimer's Disease/Alzheimer's Disease-Related Dementias (AD/ADRD) is critical to discovering new targets to test for preventive and therapeutic interventions. Metabolic dysregulation, both systemic (e.g., diabetes) and cerebral ...

Research Terms

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JOSEPH M ANDREANO

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$825,324

FY 2026

Project Title

Influence of the Menopausal Transition and Lifetime Ovarian Exposure on Neural Metabolism, Connectivity and Pathology

Grant Number:

5R01AG085643-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Women are significantly more likely to develop Alzheimer’s disease than men, making up 2/3 of all AD cases. Growing evidence suggests that this difference is related to the decline in ovarian hormone levels experienced by women at midlife through menopause. Women who experience menopause later in li...

Research Terms

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BRADFORD C DICKERSON

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$825,324

FY 2026

Project Title

Influence of the Menopausal Transition and Lifetime Ovarian Exposure on Neural Metabolism, Connectivity and Pathology

Grant Number:

5R01AG085643-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Women are significantly more likely to develop Alzheimer’s disease than men, making up 2/3 of all AD cases. Growing evidence suggests that this difference is related to the decline in ovarian hormone levels experienced by women at midlife through menopause. Women who experience menopause later in li...

Research Terms

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William Olaf Hancock

PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$816,787

FY 2026

Project Title

Molecular mechanism of bidirectional transport

Grant Number:

2R35GM139568-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2021

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY In cells, bidirectional transport of vesicles and organelles involves a tug-of-war between kinesin and dynein motors as they carry cargo along microtubule tracks. This transport is particularly important in the elongated axons and dendrites of neurons, and transport defects are linke...

Research Terms

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Changning Wang

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$806,956

FY 2026

Project Title

New epigenetic inhibitors for Alzheimer's disease treatment

Grant Number:

5R01AG086433-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Alzheimer’s disease (AD) is a neurodegenerative disorder that is the primary cause of dementia, the mechanisms of AD have not been completely elucidated and there has yet to yield effective therapy that can prevent, stop or reverse cognitive deficits associated with AD. Epigenetics r...

Research Terms

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Can Martin Zhang

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$806,956

FY 2026

Project Title

New epigenetic inhibitors for Alzheimer's disease treatment

Grant Number:

5R01AG086433-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Alzheimer’s disease (AD) is a neurodegenerative disorder that is the primary cause of dementia, the mechanisms of AD have not been completely elucidated and there has yet to yield effective therapy that can prevent, stop or reverse cognitive deficits associated with AD. Epigenetics r...

Research Terms

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Li Gan

CORNELL UNIVERSITY, ITHACA, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$806,051

FY 2026

Project Title

Genome-wide identification and characterization of Alzheimer's Disease-associated enhancers

Grant Number:

5R01AG077899-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT The sequencing of many tens of thousands of human genomes has revealed a plethora of sequence differences or variants. Most variants appear to be of no or little functional consequence; however, a small fraction of these variants can alter genome regulation and the susceptib...

Research Terms

<3-D><3-Dimensional><3C-based approach><3C-based assay><3C-based method><3C-based strategy><3C-based technique><3C-based technology><3D><4C-seq><AD dementia><AD pathway><AD-associated pathways><AD-related pathways><AD-specific pathways><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Amentia><Architecture><Assay><Basal Transcription Factor><Basal transcription factor genes><Base Pairing><Binding><Bioassay><Biological Assay><CRISPR><CRISPR/Cas system><Cell Body><Cell Line><CellLine><Cells><Characteristics><Chromatin><Chromatin Conformation Capture and Sequencing><Clustered Regularly Interspaced Short Palindromic Repeats><DNA mutation><Data><Data Set><Dementia><Development><Disease><Disease Pathway><Disease Progression><Disorder><Distal><Drugs><Elements><Engineering / Architecture><Enhancer Elements><Enhancers><Functional RNA><GWA study><GWAS><Gene Action Regulation><Gene Alteration><Gene Expression Regulation><Gene Mutation><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Change><Genetic Diversity><Genetic Enhancer Element><Genetic Materials><Genetic Transcription><Genetic Variation><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genome><Genomics><Goals><Health Care Systems><High Throughput Assay><Hortega cell><Human Genome><Maps><Measures><Medication><Microglia><Modeling><Molecular><Molecular Interaction><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Needles><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><PRO-seq><Pathologic><Patients><Pattern><Persons><Pharmaceutical Preparations><Phenotype><Precision Run-On Sequencing><Precision nuclear run-on sequencing><Predisposition><Primary Senile Degenerative Dementia><Prognosis><Protocol><Protocols documentation><RNA><RNA Expression><RNA Gene Products><Regulation><Regulator Genes><Resolution><Ribonucleic Acid><Sampling><Strains Cell Lines><Susceptibility><Testing><Therapeutic Intervention><Transcription><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activator/Coactivator><Transcriptional Regulatory Elements><Untranslated RNA><Variant><Variation><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging population><cell type><chromatin conformation capture><chromosome capture><chromosome conformation capture><cultured cell line><developmental><disease phenotype><drug/agent><enhancer sequence><entire genome><excitatory neuron><full genome><gene defect><gene locus><gene regulatory network><genetic enhancer sequence><genetic locus><genetic trans acting element><genome mutation><genome scale><genome sequencing><genome wide analysis><genome wide association><genome wide association scan><genome wide association study><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><genomewide association scan><genomewide association study><genomic location><genomic locus><gitter cell><high throughput screening><human whole genome><iPS><iPSC><iPSCs><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intervention therapy><low-frequency mutation><mechanisms in AD><mechanisms in Alzheimer's disease><mesoglia><microglial cell><microgliocyte><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mutant><mutant allele><noncoding><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><perivascular glial cell><population aging><primary degenerative dementia><promoter><promotor><rare allele><rare mutation><rare variant><regulatory gene><resolutions><senile dementia of the Alzheimer type><synergism><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><three dimensional><trans acting element><transcription factor><whole genome><whole genome association analysis><whole genome association study>

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JOHN T LIS

CORNELL UNIVERSITY, ITHACA, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$806,051

FY 2026

Project Title

Genome-wide identification and characterization of Alzheimer's Disease-associated enhancers

Grant Number:

5R01AG077899-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT The sequencing of many tens of thousands of human genomes has revealed a plethora of sequence differences or variants. Most variants appear to be of no or little functional consequence; however, a small fraction of these variants can alter genome regulation and the susceptib...

Research Terms

<3-D><3-Dimensional><3C-based approach><3C-based assay><3C-based method><3C-based strategy><3C-based technique><3C-based technology><3D><4C-seq><AD dementia><AD pathway><AD-associated pathways><AD-related pathways><AD-specific pathways><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Amentia><Architecture><Assay><Basal Transcription Factor><Basal transcription factor genes><Base Pairing><Binding><Bioassay><Biological Assay><CRISPR><CRISPR/Cas system><Cell Body><Cell Line><CellLine><Cells><Characteristics><Chromatin><Chromatin Conformation Capture and Sequencing><Clustered Regularly Interspaced Short Palindromic Repeats><DNA mutation><Data><Data Set><Dementia><Development><Disease><Disease Pathway><Disease Progression><Disorder><Distal><Drugs><Elements><Engineering / Architecture><Enhancer Elements><Enhancers><Functional RNA><GWA study><GWAS><Gene Action Regulation><Gene Alteration><Gene Expression Regulation><Gene Mutation><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Change><Genetic Diversity><Genetic Enhancer Element><Genetic Materials><Genetic Transcription><Genetic Variation><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genome><Genomics><Goals><Health Care Systems><High Throughput Assay><Hortega cell><Human Genome><Maps><Measures><Medication><Microglia><Modeling><Molecular><Molecular Interaction><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Needles><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><PRO-seq><Pathologic><Patients><Pattern><Persons><Pharmaceutical Preparations><Phenotype><Precision Run-On Sequencing><Precision nuclear run-on sequencing><Predisposition><Primary Senile Degenerative Dementia><Prognosis><Protocol><Protocols documentation><RNA><RNA Expression><RNA Gene Products><Regulation><Regulator Genes><Resolution><Ribonucleic Acid><Sampling><Strains Cell Lines><Susceptibility><Testing><Therapeutic Intervention><Transcription><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activator/Coactivator><Transcriptional Regulatory Elements><Untranslated RNA><Variant><Variation><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging population><cell type><chromatin conformation capture><chromosome capture><chromosome conformation capture><cultured cell line><developmental><disease phenotype><drug/agent><enhancer sequence><entire genome><excitatory neuron><full genome><gene defect><gene locus><gene regulatory network><genetic enhancer sequence><genetic locus><genetic trans acting element><genome mutation><genome scale><genome sequencing><genome wide analysis><genome wide association><genome wide association scan><genome wide association study><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><genomewide association scan><genomewide association study><genomic location><genomic locus><gitter cell><high throughput screening><human whole genome><iPS><iPSC><iPSCs><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intervention therapy><low-frequency mutation><mechanisms in AD><mechanisms in Alzheimer's disease><mesoglia><microglial cell><microgliocyte><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mutant><mutant allele><noncoding><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><perivascular glial cell><population aging><primary degenerative dementia><promoter><promotor><rare allele><rare mutation><rare variant><regulatory gene><resolutions><senile dementia of the Alzheimer type><synergism><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><three dimensional><trans acting element><transcription factor><whole genome><whole genome association analysis><whole genome association study>

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Haiyuan Yu

CORNELL UNIVERSITY, ITHACA, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$806,051

FY 2026

Project Title

Genome-wide identification and characterization of Alzheimer's Disease-associated enhancers

Grant Number:

5R01AG077899-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT The sequencing of many tens of thousands of human genomes has revealed a plethora of sequence differences or variants. Most variants appear to be of no or little functional consequence; however, a small fraction of these variants can alter genome regulation and the susceptib...

Research Terms

<3-D><3-Dimensional><3C-based approach><3C-based assay><3C-based method><3C-based strategy><3C-based technique><3C-based technology><3D><4C-seq><AD dementia><AD pathway><AD-associated pathways><AD-related pathways><AD-specific pathways><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Amentia><Architecture><Assay><Basal Transcription Factor><Basal transcription factor genes><Base Pairing><Binding><Bioassay><Biological Assay><CRISPR><CRISPR/Cas system><Cell Body><Cell Line><CellLine><Cells><Characteristics><Chromatin><Chromatin Conformation Capture and Sequencing><Clustered Regularly Interspaced Short Palindromic Repeats><DNA mutation><Data><Data Set><Dementia><Development><Disease><Disease Pathway><Disease Progression><Disorder><Distal><Drugs><Elements><Engineering / Architecture><Enhancer Elements><Enhancers><Functional RNA><GWA study><GWAS><Gene Action Regulation><Gene Alteration><Gene Expression Regulation><Gene Mutation><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Change><Genetic Diversity><Genetic Enhancer Element><Genetic Materials><Genetic Transcription><Genetic Variation><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Genome><Genomics><Goals><Health Care Systems><High Throughput Assay><Hortega cell><Human Genome><Maps><Measures><Medication><Microglia><Modeling><Molecular><Molecular Interaction><Mutagenesis><Mutagenesis Molecular Biology><Mutation><Needles><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><PRO-seq><Pathologic><Patients><Pattern><Persons><Pharmaceutical Preparations><Phenotype><Precision Run-On Sequencing><Precision nuclear run-on sequencing><Predisposition><Primary Senile Degenerative Dementia><Prognosis><Protocol><Protocols documentation><RNA><RNA Expression><RNA Gene Products><Regulation><Regulator Genes><Resolution><Ribonucleic Acid><Sampling><Strains Cell Lines><Susceptibility><Testing><Therapeutic Intervention><Transcription><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activator/Coactivator><Transcriptional Regulatory Elements><Untranslated RNA><Variant><Variation><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging population><cell type><chromatin conformation capture><chromosome capture><chromosome conformation capture><cultured cell line><developmental><disease phenotype><drug/agent><enhancer sequence><entire genome><excitatory neuron><full genome><gene defect><gene locus><gene regulatory network><genetic enhancer sequence><genetic locus><genetic trans acting element><genome mutation><genome scale><genome sequencing><genome wide analysis><genome wide association><genome wide association scan><genome wide association study><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><genomewide association scan><genomewide association study><genomic location><genomic locus><gitter cell><high throughput screening><human whole genome><iPS><iPSC><iPSCs><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intervention therapy><low-frequency mutation><mechanisms in AD><mechanisms in Alzheimer's disease><mesoglia><microglial cell><microgliocyte><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mutant><mutant allele><noncoding><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><perivascular glial cell><population aging><primary degenerative dementia><promoter><promotor><rare allele><rare mutation><rare variant><regulatory gene><resolutions><senile dementia of the Alzheimer type><synergism><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><three dimensional><trans acting element><transcription factor><whole genome><whole genome association analysis><whole genome association study>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

CATHERINE COOK KACZOROWSKI

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$787,595

FY 2026

Project Title

Systems Genetics Analysis of Alzheimer's Disease-Related Sleep Loss and the Transition to Dementia

Grant Number:

5R01AG076129-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Our proposed research is expected to identify genetic factors that underlie disordered sleep associated with Alzheimer's disease (AD), and determine if they are intervenable to stave off cognitive symptoms. Detection and validation of these genes will promote possible treatments thro...

Research Terms

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John R Lukens

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$760,384

FY 2026

Project Title

Alzheimer's Disease Therapy via the MR Image-Guided Deletion of Microglial SHIP-1 with Focused Ultrasound

Grant Number:

5R01AG086344-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Microglia play a key role in Alzheimer’s disease (AD) pathogenesis and represent promising targets in the development of new Alzheimer’s Disease treatments. INPP5D, a gene that encodes for the SH2-domain- containing inositol phosphatase SHIP-1 and is predominantly expressed by microglia in the brain...

Research Terms

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Richard J. Price

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$760,384

FY 2026

Project Title

Alzheimer's Disease Therapy via the MR Image-Guided Deletion of Microglial SHIP-1 with Focused Ultrasound

Grant Number:

5R01AG086344-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Microglia play a key role in Alzheimer’s disease (AD) pathogenesis and represent promising targets in the development of new Alzheimer’s Disease treatments. INPP5D, a gene that encodes for the SH2-domain- containing inositol phosphatase SHIP-1 and is predominantly expressed by microglia in the brain...

Research Terms

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Jiang Bian

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$749,314

FY 2026

Project Title

Disparities of Alzheimer's disease progression in Sexual Minority Individuals

Grant Number:

5R01AG080624-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Sexual Minority (SM) individuals face unique health issues, but studies on SM health are scarce. In particular, limited data are available among SM individuals on age-related conditions such as Alzheimer’s disease (AD) and related dementias. AD is a fatal degenerative disease with a diverse range of...

Research Terms

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Yi Guo

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$749,314

FY 2026

Project Title

Disparities of Alzheimer's disease progression in Sexual Minority Individuals

Grant Number:

5R01AG080624-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Sexual Minority (SM) individuals face unique health issues, but studies on SM health are scarce. In particular, limited data are available among SM individuals on age-related conditions such as Alzheimer’s disease (AD) and related dementias. AD is a fatal degenerative disease with a diverse range of...

Research Terms

View Full Project Details on NIH Reporter

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Fei Wang

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$749,314

FY 2026

Project Title

Disparities of Alzheimer's disease progression in Sexual Minority Individuals

Grant Number:

5R01AG080624-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Sexual Minority (SM) individuals face unique health issues, but studies on SM health are scarce. In particular, limited data are available among SM individuals on age-related conditions such as Alzheimer’s disease (AD) and related dementias. AD is a fatal degenerative disease with a diverse range of...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Laura B Zahodne

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$741,260

FY 2026

Project Title

Mechanisms of ADRD risk disparities in the Michigan Cognitive Aging Project

Grant Number:

5R01AG082307-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Risk of Alzheimer’s disease and related dementias (ADRD) is higher for Black older adults than for White older adults. This disparity is not fully explained by commonly measured individual risk factors such as education, apolipoprotein-epsilon 4, or medical comorbidities. Thus, there is a critical n...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD model><AD pathway><AD related dementia><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><ADRD><Access to Care><Adult><Adult Human><Affect><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease model><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Ammon Horn><Apolipoproteins><Area><Attenuated><Behavioral><Black><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Brain><Brain Nervous System><Censuses><Characteristics><Childhood><Cognitive><Cognitive aging><Communities><Control Locus><Cornu Ammonis><Country><Data><Decrease health disparities><Diet><Disadvantaged><Disparities><Disparity><Economic Income><Economical Income><Education><Educational aspects><Emotional Depression><Encephalon><Ensure><Family><Generalized Growth><Goals><Growth><Health><Health Services><Health Services Accessibility><Health behavior><Health disparity mitigation><Health disparity reduction><Hippocampus><History><Income><Individual><Infrastructure><Internet><Interruption><Intervention><Knowledge><Leisure Activities><Life Cycle><Life Cycle Stages><Link><Longitudinal Studies><Longitudinal Surveys><Lower health disparities><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Michigan><Mitigate health disparities><Modeling><NMR Imaging><NMR Tomography><Neighborhoods><Neuropsychologies><Neuropsychology><Nuclear Magnetic Resonance Imaging><Outcome><Participant><Pathway interactions><Personal awareness><Physical activity><Policies><Population><Primary Senile Degenerative Dementia><Process><Race><Races><Racial Group><Recording of previous events><Reduce health disparities><Religion><Reporting><Research><Research Resources><Resources><Risk><Risk Factors><Self Perception><Self image><Self view><Social Service><Social Work><Social support><Socio-economic status><Socioeconomic Status><Stress><Thick><Thickness><Time><Tissue Growth><United States><WWW><White Matter Hyperintensity><Zeugmatography><access to health services><access to services><access to treatment><accessibility to health services><accumulated exposure><accumulated long-term exposure><adulthood><aggregate exposure><alzheimer model><alzheimer risk><analyzing longitudinal><attenuate><attenuates><attenuation><availability of services><care access><co-morbid><co-morbidity><cohort><comorbidity><critical period><cumulative exposure><cumulative life exposure><cumulative long-term exposure><data archive><data archives><dementia risk><depression symptom><depressive><depressive symptoms><diets><differences due to race><differences in race><differs by race><differs in race><disparity in health><experience><exposome><health disparity><health related behavior><health service access><health services availability><hippocampal><histories><incomes><late in life><late life><life course><life-course exposure><lifelong exposure><lifespan exposure><lifetime exposure><long-term study><longitudinal analysis><longitudinal outcome studies><longitudinal research study><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><mechanisms in AD><mechanisms in Alzheimer's disease><mid life><mid-life><middle age><middle aged><midlife><mortality><neuropsychologic><novel><older adult><older adulthood><ontogeny><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><pediatric><primary degenerative dementia><psychologic><psychological><psychosocial><race based differences><race differences><race related differences><racial><racial background><racial difference><racial origin><racial population><racial subgroup><racially different><recruit><religious><resilience factor><resiliency factor><response><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><self awareness><self knowledge><senile dementia of the Alzheimer type><service availability><social><social cohesion><social group><social support network><socio-economic position><socioeconomic position><theories><totality of exposures><treatment access><web><world wide web>

View Full Project Details on NIH Reporter

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Oleg Butovsky

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$738,078

FY 2026

Project Title

Sex-dependent APOE4 regulation of neutrophil-microglia crosstalk in Alzheimer's disease

Grant Number:

5R01AG075509-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

APOE4 is the strongest genetic risk factor for late-onset Alzheimer’s disease (LOAD). The role of human APOE variants in AD has been studied extensively in the regulation of microglia and astrocytes but not in neutrophils. APOE is also expressed in neutrophils and controls their activation. Moreover...

Research Terms

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Andrew James Sharp

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$729,672

FY 2026

Project Title

A comprehensive study of tandem repeat variation as a cause of Alzheimer's disease

Grant Number:

4R01AG075051-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Tandem Repeat Expansions (TREs), most commonly of triplet repeats such as poly(CAG), are known to underlie >40 different human neurological diseases. While the majority of TREs identified to date have been found in late-onset neuro-degenerative disorders such as hereditary ataxias and Huntington dis...

Research Terms

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Aliza Pham Wingo

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$712,490

FY 2026

Project Title

Integrative genomic, transcriptomic, and proteomic analyses to investigate sex-specific differences in Alzheimer's Disease

Grant Number:

5R01AG075827-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Alzheimer's disease (AD) affects 35 million people worldwide. However, there is no effective treatments to slow or halt the underlying neurodegeneration of AD. Strikingly, women are affected by AD about twice as much as men. Why women are disproportionately affected by AD is not well understood. He...

Research Terms

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Thomas Spurgeon Wingo

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$712,490

FY 2026

Project Title

Integrative genomic, transcriptomic, and proteomic analyses to investigate sex-specific differences in Alzheimer's Disease

Grant Number:

5R01AG075827-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Alzheimer's disease (AD) affects 35 million people worldwide. However, there is no effective treatments to slow or halt the underlying neurodegeneration of AD. Strikingly, women are affected by AD about twice as much as men. Why women are disproportionately affected by AD is not well understood. He...

Research Terms

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ANDREAS A LINNINGER

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$707,254

FY 2026

Project Title

Image-based cerebrovascular network snythesis(iCNS) to model Alzheimer's Disease

Grant Number:

5R01AG079894-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Significant resources on age-related neurodegeneration are directed toward animal research in the assumption that results will inform our understanding of parallel processes in human. Yet, no reliable method exists to accurately translate cerebral blood flow or metabolic data from animal to human. F...

Research Terms

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Chen Zhao

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$705,438

FY 2026

Project Title

Leveraging HSF1 Attenuation to Transform Clonal Hematopoiesis into Beneficial Hematopoiesis

Grant Number:

5R01HL176819-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/5/2024

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary_Abstract Age-related clonal hematopoiesis (CH), characterized by the enhanced fitness of hematopoietic stem/progenitor cells (HSPCs) carrying somatic mutations, is associated with increased risks of developing hematological malignancies such as myelodysplastic syndrome or acute myelo...

Research Terms

<21+ years old><5-FU><5-Fluracil><5FU><AD risk><AD risk factor><AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><Adult><Adult Human><Aging><Alzheimer risk factor><Alzheimer's disease risk><Blood Precursor Cell><Bone Marrow><Bone Marrow Blood-Deriving Cell><Bone Marrow Blood-Forming Cell><Bone Marrow Cells><Bone Marrow Reticuloendothelial System><CCAAT-Box Binding Transcription Factor><COPD><CUT&RUN><Cancers><Cardiovascular Diseases><Cell Body><Cells><Cellular Stress><Cellular Stress Response><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Cleavage Targets and Release Using Nuclease><Cleavage Under Targets and Release Using Nuclease><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Consensus><DNA Methylation><DNA methylation profiling><DNA mutation><DNMT3a><Data><Degenerative Neurologic Disorders><Development><Disease><Disorder><Dysmyelopoietic Syndromes><Ensure><Exhibits><Fluoro Uracil><Fluorouracil><Fluoruracil><Fluouracil><GVL><Gene set enrichment analysis><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Glycolysis><Glycolysis Pathway><HSC regeneration><HSC self-renewal><HSF2><Heat-Shock Transcription Factor 2><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoiesis><Hematopoietic Cancer><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Immunity><Incidence><Infection><Intermediary Metabolism><Intervention><Investigation><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Leukemic progenitor and stem cell><Link><Lymphocytic Neoplasm><Lymphocytic Tumor><Lymphocytic and Plasma Cell Neoplasm><Lymphocytic and Plasma Cell Tumour><Lymphocytic and Plasmacytic Neoplasm><Lymphoid Tumor><Lymphoid and Plasma Cell Tumour><Lymphoid and Plasmacytic Neoplasm><Lymphoid and Plasmacytic Tumour><Malignant Hematologic Neoplasm><Malignant Neoplasms><Malignant Tumor><Metabolic Processes><Metabolism><Methyl-Seq><MethylSeq><Methylation sequencing><Mitochondria><Molecular><Mutation><Myelodysplastic Disease><Myelodysplastic Syndromes><Myeloid Disease><Myeloid Malignancy><Myeloid Neoplasm><Myeloid Tumor><Myeloproliferative Disorders><Myeloproliferative Tumors><Myeloproliferative disease><NF-I Protein><NFI Transcription Factor><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Nuclear Factor I><Null Mouse><Oncogenic><Outcome><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Pathway interactions><Play><Precancerous Conditions><Premalignant Condition><Premalignant State><Prevention><Progenitor Cell Engraftment><RNA Seq><RNA sequencing><RNAseq><Radiation><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Regulation><Research><Risk><Role><Scheme><Smoldering Leukemia><Solid Neoplasm><Solid Tumor><Somatic Mutation><Stress><Symptoms><T-Cells><T-Lymphocyte><Therapeutic><Therapeutic Intervention><Upregulation><acute granulocytic leukemia><acute myeloid leukemia><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aging associated disease><aging associated disorders><aging related disease><aging related disorders><alzheimer risk><attenuation><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood stem cell regeneration><blood stem cell self-renewal><blood-forming stem cell><cardiovascular disorder><cell stress><chronic obstructive pulmonary disorder><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><cytokine><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><fitness><genome mutation><glucose uptake><graft versus leukemia><graft vs leukemia><graft vs leukemia effect><graft vs leukemia response><graft vs. leukemia><graft vs. leukemia effect><graft vs. leukemia response><hDNA methyltransferase 3a><heat shock transcription factor><hematopoietic cell clones><hematopoietic progenitor><hematopoietic progenitor cell self-renewal><hematopoietic stem cell clonality><hematopoietic stem cell regeneration><hematopoietic stem cell self-renewal><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><insight><intervention therapy><leukemia stem/initiating cells><leukemic progenitor><leukemic stem cell><lymphoid neoplasm><malignancy><microbial><mitochondrial><mouse model><multiomics><multiple omics><murine model><myelodysplasia><myeloproliferative neoplasm><neoplasm/cancer><neurodegenerative illness><nuclear factor 1><panomics><pathway><pharmacologic><precancerous state><preservation><prevent><preventing><progenitor cell function><progenitor cell homeostasis><progenitor function><protein expression><regeneration of blood stem cells><response><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><scRNA sequencing><scRNA-seq><self - renewal in hematopoietic stem cells><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><somatic variant><stem and progenitor cell function><stem and progenitor function><stem cell engraftment><stem cell function><stem cell homeostasis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><thymus derived lymphocyte><transcriptome sequencing><transcriptomic sequencing>

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John Patrick Haran

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$703,465

FY 2026

Project Title

Understanding the Microbiome-gut-brain axis in Alzheimers disease and its Role

Grant Number:

2R01AG067483-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2020

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT The gut microbiome is emerging as a possible causative trigger for disease progression in Alzheimer's disease (AD) via systemic immune dysfunction. While full progression to clinical disease is complex and multifactorial, our ongoing work points to a novel microbiome-gut-brain axis associat...

Research Terms

<21+ years old><AD brain><AD dementia><AD pathology><AD patients><AD prevention><AD risk><AD risk factor><AD transgenic mice><Adult><Adult Human><Affect><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease prevention><Alzheimer prevention><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease risk><Alzheimer's disease transgenic mice><Alzheimer's pathology><Alzheimer's patient><Alzheimer's transgenic mice><Alzheimers Dementia><Amentia><Automobile Driving><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Cellular Immune Function><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Complex><Data><Dementia><Development><Disease><Disease Progression><Disorder><Disturbance in cognition><Dysfunction><Feces><Functional disorder><Funding><Future><GI microbiome><Goals><Grant><Human><IQ Deficit><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunes><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Impaired cognition><Inflammation><Investigation><Investigators><Lead><Long-term cohort><Longitudinal cohort><Mediating><Methionine><Methionine Metabolism><Methionine Metabolism Pathway><Microbiomics><Modern Man><Neurocognitive><Neurocognitive Deficit><Neurologic Dysfunctions><Pathologic><Pathway interactions><Patients><Pb element><Peripheral><Phenotype><Physiopathology><Prevention><Primary Senile Degenerative Dementia><Process><Production><Research><Research Personnel><Researchers><Risk><Role><Sampling><Study Subject><Symptoms><T-Cells><T-Lymphocyte><Time><Transgenic Organisms><Transplantation><Vulnerable Populations><Work><abnormal brain function><absorption><adulthood><ages><alzheimer risk><brain dysfunction><brain impairment><cognitive change><cognitive dysfunction><cognitive loss><cohort><cohort investigation><cohort research><deep sequencing><developmental><diet control><dietary control><digestive tract microbiome><driving><dysbacteriosis><dysbiosis><dysbiotic><dysfunctional brain><enteric microbiome><fecal sample><gastrointestinal microbiome><gut microbes><gut microbial species><gut microbiome><gut to brain axis><gut-associated microbiome><gut-brain axis><gut-brain communication><gut-brain interactions><gut-brain relationship><gut-brain signaling><heavy metal Pb><heavy metal lead><immune function><immune senescence><immunopathology><immunosenescence><intelligence quotient deficit><intestinal biome><intestinal epithelium><intestinal microbes><intestinal microbiome><investigate cohort><metabolism measurement><metabolomics><metabonomics><microbial imbalance><microbiome><microbiome intervention><microbiome research><microbiome science><microbiome studies><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><mouse model><murine model><neural><neural inflammation><neurocognitive decline><neurocognitive impairment><neuroinflammation><neuroinflammatory><neurological dysfunction><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><older adult><older adulthood><pathophysiology><pathway><patient living with Alzheimer's disease><patient population><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><primary degenerative dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><scRNA sequencing><scRNA-seq><senescence and its associated secretory phenotype><senescence associated secretome><senescence associated secretory factors><senescence associated secretory pathway><senescence associated secretory phenotype><senescence associated secretory program><senescence associated secretory proteins><senescent associated secretome><senescent associated secretory phenotype><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stool><stool sample><stool specimen><study cohort><success><survey cohort><synergism><thymus derived lymphocyte><transgenic><transgenic AD model><transgenic Alzheimer's model><transgenic model of alzheimer disease><transplant><vulnerable group><vulnerable individual><vulnerable people>

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Kristen Knutson

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$691,009

FY 2026

Project Title

The Proteomic Signature of Sleep and its implication for Alzheimer's Disease

Grant Number:

1R01AG089354-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Alzheimer's Disease (AD) is characterized by progressive cognitive decline leading to mortality and is a leading cause of death among older adults. The disease involves the formation of plaques and tangles in the brain, which hinder cognitive functioning. Alzheimer's Disease is also ...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD and related dementia><AD biological marker><AD biomarker><AD dementia><AD pathway><AD related biomarker><AD related dementia><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><ADRD><Active Follow-up><Address><Adult><Adult Human><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's biomarker><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related biomarker><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's related biomarker><Alzheimer's related pathways><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Architecture><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Brain><Brain Nervous System><Brazil><CNS lymphatic system><Cause of Death><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Data><Dementia><Development><Dimensions><Disease><Disease Progression><Disorder><Disturbance in cognition><EEG><Electroencephalogram><Electroencephalography><Encephalon><Engineering / Architecture><Evaluation><Experimental Designs><Genes><Goals><Graph><Heart><Hour><Human><IFN><Impaired cognition><Individual><Interferons><Knowledge><Link><Long-term Follow-up><Longitudinal Studies><Longitudinal Surveys><MT-bound tau><Maintenance><Maps><Measures><Mediating><Memory><Modern Man><Molecular><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocognition><Neurocognitive><Neurocyte><Neurofibrillary Tangles><Neuron Degeneration><Neurons><Participant><Pathway interactions><Performance><Phenotype><Play><Polysomnography><Predisposing Factor><Primary Senile Degenerative Dementia><Process><Proteins><Proteomics><Protocol><Protocols documentation><Research><Risk><Risk Factors><Role><Sampling><Sleep><Sleep Architecture><Sleep Monitoring><Sleep disturbances><Somnography><System><Testing><Time><aberrant sleep><above age 65><active followup><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><alzheimer risk><bio-markers><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><brain health><brain lymph system><brain lymphatic system><cognitive assessment><cognitive change><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive testing><design><designing><developmental><disability><disrupted sleep><disturbed sleep><endophenotype><experiment><experimental research><experimental study><experiments><follow up><follow-up><followed up><followup><glia lymphatic circuit><glia-lymphatic system><glial lymphatic system><glialymphatic circuit><glialymphatic network><glialymphatic pathway><glialymphatic system><glymphatic clearance pathway><glymphatic pathway><glymphatic system><glymphatic-lymphatic system><glymphatics><human old age (65+)><impaired sleep><improved><inter-individual variability><inter-individual variation><irregular sleep><knowledge graph><long-term followup><long-term study><longitudinal outcome studies><longitudinal research study><mechanisms in AD><mechanisms in Alzheimer's disease><microtubule bound tau><microtubule-bound tau><molecular biomarker><molecular marker><mortality><neural degeneration><neurocognitive test><neurodegeneration><neurodegenerative><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurological degeneration><neuronal><neuronal degeneration><novel><older adult><older adulthood><over 65 years><paravascular system><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><primary degenerative dementia><protein biomarkers><protein markers><proteomic signature><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sleep disruption><sleep dysregulation><sleep measurement><sleep polysomnography><sleep/wake disruption><sleep/wake disturbance><social role><tangle><tau><tau Proteins><tau factor><τ Proteins><≥65 years>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Alexandre C Pereira

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$691,009

FY 2026

Project Title

The Proteomic Signature of Sleep and its implication for Alzheimer's Disease

Grant Number:

1R01AG089354-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Alzheimer's Disease (AD) is characterized by progressive cognitive decline leading to mortality and is a leading cause of death among older adults. The disease involves the formation of plaques and tangles in the brain, which hinder cognitive functioning. Alzheimer's Disease is also ...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD and related dementia><AD biological marker><AD biomarker><AD dementia><AD pathway><AD related biomarker><AD related dementia><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><ADRD><Active Follow-up><Address><Adult><Adult Human><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's biomarker><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related biomarker><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's related biomarker><Alzheimer's related pathways><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Architecture><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Brain><Brain Nervous System><Brazil><CNS lymphatic system><Cause of Death><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Data><Dementia><Development><Dimensions><Disease><Disease Progression><Disorder><Disturbance in cognition><EEG><Electroencephalogram><Electroencephalography><Encephalon><Engineering / Architecture><Evaluation><Experimental Designs><Genes><Goals><Graph><Heart><Hour><Human><IFN><Impaired cognition><Individual><Interferons><Knowledge><Link><Long-term Follow-up><Longitudinal Studies><Longitudinal Surveys><MT-bound tau><Maintenance><Maps><Measures><Mediating><Memory><Modern Man><Molecular><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocognition><Neurocognitive><Neurocyte><Neurofibrillary Tangles><Neuron Degeneration><Neurons><Participant><Pathway interactions><Performance><Phenotype><Play><Polysomnography><Predisposing Factor><Primary Senile Degenerative Dementia><Process><Proteins><Proteomics><Protocol><Protocols documentation><Research><Risk><Risk Factors><Role><Sampling><Sleep><Sleep Architecture><Sleep Monitoring><Sleep disturbances><Somnography><System><Testing><Time><aberrant sleep><above age 65><active followup><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><alzheimer risk><bio-markers><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><brain health><brain lymph system><brain lymphatic system><cognitive assessment><cognitive change><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive testing><design><designing><developmental><disability><disrupted sleep><disturbed sleep><endophenotype><experiment><experimental research><experimental study><experiments><follow up><follow-up><followed up><followup><glia lymphatic circuit><glia-lymphatic system><glial lymphatic system><glialymphatic circuit><glialymphatic network><glialymphatic pathway><glialymphatic system><glymphatic clearance pathway><glymphatic pathway><glymphatic system><glymphatic-lymphatic system><glymphatics><human old age (65+)><impaired sleep><improved><inter-individual variability><inter-individual variation><irregular sleep><knowledge graph><long-term followup><long-term study><longitudinal outcome studies><longitudinal research study><mechanisms in AD><mechanisms in Alzheimer's disease><microtubule bound tau><microtubule-bound tau><molecular biomarker><molecular marker><mortality><neural degeneration><neurocognitive test><neurodegeneration><neurodegenerative><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurological degeneration><neuronal><neuronal degeneration><novel><older adult><older adulthood><over 65 years><paravascular system><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><primary degenerative dementia><protein biomarkers><protein markers><proteomic signature><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sleep disruption><sleep dysregulation><sleep measurement><sleep polysomnography><sleep/wake disruption><sleep/wake disturbance><social role><tangle><tau><tau Proteins><tau factor><τ Proteins><≥65 years>

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Zhenyu Yue

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$673,953

FY 2026

Project Title

Neuronal Autophagy: a Cell-Autonomous Protection Mechanism

Grant Number:

5R01NS060123-19

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2008

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Our goal is to elucidate neuroprotective mechanisms of autophagy and harness the knowledge to develop therapeutic strategies for neurodegenerative diseases. Autophagy is a major catabolic process involving the synthesis, transport, and degradation of autophagosomes, which sequester and recycle large...

Research Terms

<21+ years old><A kinase anchoring protein><AD dementia><AD model><AD pathway><AD-associated pathways><AD-related pathways><AD-specific pathways><AKAP><Adenosine Cyclic Monophosphate-Dependent Protein Kinases><Adult><Adult Human><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's disease model><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Animal Model><Animal Models and Related Studies><Autophagocytosis><Autophagosome><Autoregulation><Axon><Behavioral><Brain><Brain Nervous System><Catabolic Process><Cell Body><Cell model><Cells><Cellular biology><Cellular model><Complex><Cyclic AMP-Dependent Protein Kinases><DA Neuron><DNA Molecular Biology><Degenerative Neurologic Disorders><Disease><Disorder><Dopamine neuron><Encephalon><Funding><Gehrig's Disease><Genetic><Genetic study><Goals><Homeostasis><Hortega cell><Human><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><Kinases><Knock-out><Knockout><Knowledge><Lou Gehrig Disease><Lysosomes><Maintenance><Maps><Mediating><Mesencephalon><Metabolic Protein Degradation><Mice><Mice Mammals><Microglia><Mid-brain><Midbrain><Midbrain structure><Modern Man><Molecular><Molecular Biology><Murine><Mus><Mutant Strains Mice><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurons><Organelles><PARK20><PKA><Paralysis Agitans><Parkinson><Parkinson Disease><Pathogenicity><Pathologic><Pathway interactions><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiological><Physiological Homeostasis><Primary Parkinsonism><Primary Senile Degenerative Dementia><Protein Kinase A><Protein Turnover><Proteins><Proteomics><Quality Control><Receptor Protein><Recycling><Regulation><Regulatory Protein Degradation><Reporting><Role><SYNJ1><SYNJ1 gene><Synaptic Vesicles><Therapeutic><Transphosphorylases><Validation><adulthood><age associated><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age correlated><age dependent><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age linked><age related><age related neurodegeneration><age specific><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><ages><aging associated neurodegeneration><aging associated neurodegenerative disease><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><alzheimer model><autophagy><cAMP-Dependent Protein Kinases><cell biology><cell type><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><dopaminergic neuron><gitter cell><insight><insoluble aggregate><mechanisms in AD><mechanisms in Alzheimer's disease><mesoglia><microglial cell><microgliocyte><model of animal><mouse mutant><mutant><neurodegenerative illness><neuromelanin><neuronal><neuropathologic><neuropathological><neuropathology><neuroprotection><neuroprotective><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><perivascular glial cell><prevent><preventing><primary degenerative dementia><protein aggregate><protein aggregation><protein degradation><receptor><senile dementia of the Alzheimer type><social role><synaptojanin><synaptojanin-1><synaptojanin1><synucleinopathy><trafficking><validations>

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Manu S Goyal

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$661,985

FY 2026

Project Title

Deep-Learning-Augmented Quantitative Gradient Recalled Echo (DLA-qGRE) MRI for in vivo Clinical Evaluation of Brain Microstructural Neurodegeneration in Alzheimer Disease

Grant Number:

4R01AG082030-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Alzheimer Disease (AD) is one of the major health problems in the US and worldwide; it is a neurodegenerative disorder that is characterized clinically by progressive dementia caused by pathological changes in brain tissue preceding clinical symptoms by 15-20 years. Clinically-accessible methods are...

Research Terms

<3-D><3-Dimensional><3D><AD dementia><AD diagnostic><AD pathology><Abscission><Acceleration><Age><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's diagnostic><Alzheimer's disease diagnostic><Alzheimer's disease pathology><Alzheimer's disease test><Alzheimer's pathology><Alzheimer's test><Alzheimers Dementia><Amentia><Amyloid><Amyloid Substance><Applications Grants><Architecture><Artifacts><Atrophic><Atrophy><Biologic Models><Biological><Biological Models><Biophysics><Black Box><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Cell Communication and Signaling><Cell Signaling><Clinical><Clinical Evaluation><Clinical Testing><Computer software><Darkness><Data><Data Analyses><Data Analysis><Degenerative Neurologic Disorders><Dementia><Detection><Development><Diagnostic><Diagnostic tests><Disease Progression><Drug Therapy><Drugs><Encephalon><Encephalon Diseases><Engineering / Architecture><Excision><Extirpation><Future><Goals><Grant Proposals><Health><Hour><Image><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Least Squares><Least-Squares Analyses><Least-Squares Analysis><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Manufacturer><Maps><Measurement><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Methodology><Methods><Model System><Modeling><Monitor><Morphologic artifacts><Motion><NMR Imaging><NMR Tomography><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Noise><Nuclear Magnetic Resonance Imaging><Outcome Measure><Participant><Pathologic><Patients><Pattern><Persons><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Physiologic pulse><Population><Predisposition><Primary Senile Degenerative Dementia><Procedures><Property><Protocol><Protocols documentation><Pulse><RF coil><Removal><Research><Resolution><Sampling><Scanning><Sensitivity and Specificity><Signal Transduction><Signal Transduction Systems><Signaling><Software><Surgical Removal><Susceptibility><Symptoms><System><Techniques><Testing><Time><Tissues><Training><Translating><Zeugmatography><ages><biologic><biological signal transduction><biophysical foundation><biophysical model><biophysical principles><biophysical sciences><brain tissue><clinical applicability><clinical application><clinical test><cohort><computerized data processing><cost><dark matter><data acquisition><data acquisitions><data analysis pipeline><data interpretation><data processing><data processing pipeline><data to train><dataset to train><deep learning><deep learning method><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><drug intervention><drug treatment><drug/agent><early biomarkers><early detection biomarkers><early detection markers><early screening><hemodynamics><high risk><image construction><image generation><image reconstruction><imaging><imaging approach><imaging based approach><imaging system><improved><in vivo><indexing><innovate><innovation><innovative><magnetic field><measurable outcome><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><neuropathologic><neuropathological><neuropathology><novel><outcome measurement><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><physical model><pre-clinical><preclinical><prevent><preventing><primary degenerative dementia><reconstruction><research clinical testing><resection><resolutions><senile dementia of the Alzheimer type><sex><structural imaging><test for Alzheimer><three dimensional><tool><training data>

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DMITRIY A YABLONSKIY

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$661,985

FY 2026

Project Title

Deep-Learning-Augmented Quantitative Gradient Recalled Echo (DLA-qGRE) MRI for in vivo Clinical Evaluation of Brain Microstructural Neurodegeneration in Alzheimer Disease

Grant Number:

4R01AG082030-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Alzheimer Disease (AD) is one of the major health problems in the US and worldwide; it is a neurodegenerative disorder that is characterized clinically by progressive dementia caused by pathological changes in brain tissue preceding clinical symptoms by 15-20 years. Clinically-accessible methods are...

Research Terms

<3-D><3-Dimensional><3D><AD dementia><AD diagnostic><AD pathology><Abscission><Acceleration><Age><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's diagnostic><Alzheimer's disease diagnostic><Alzheimer's disease pathology><Alzheimer's disease test><Alzheimer's pathology><Alzheimer's test><Alzheimers Dementia><Amentia><Amyloid><Amyloid Substance><Applications Grants><Architecture><Artifacts><Atrophic><Atrophy><Biologic Models><Biological><Biological Models><Biophysics><Black Box><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Cell Communication and Signaling><Cell Signaling><Clinical><Clinical Evaluation><Clinical Testing><Computer software><Darkness><Data><Data Analyses><Data Analysis><Degenerative Neurologic Disorders><Dementia><Detection><Development><Diagnostic><Diagnostic tests><Disease Progression><Drug Therapy><Drugs><Encephalon><Encephalon Diseases><Engineering / Architecture><Excision><Extirpation><Future><Goals><Grant Proposals><Health><Hour><Image><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Least Squares><Least-Squares Analyses><Least-Squares Analysis><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Manufacturer><Maps><Measurement><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Methodology><Methods><Model System><Modeling><Monitor><Morphologic artifacts><Motion><NMR Imaging><NMR Tomography><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Noise><Nuclear Magnetic Resonance Imaging><Outcome Measure><Participant><Pathologic><Patients><Pattern><Persons><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Physiologic pulse><Population><Predisposition><Primary Senile Degenerative Dementia><Procedures><Property><Protocol><Protocols documentation><Pulse><RF coil><Removal><Research><Resolution><Sampling><Scanning><Sensitivity and Specificity><Signal Transduction><Signal Transduction Systems><Signaling><Software><Surgical Removal><Susceptibility><Symptoms><System><Techniques><Testing><Time><Tissues><Training><Translating><Zeugmatography><ages><biologic><biological signal transduction><biophysical foundation><biophysical model><biophysical principles><biophysical sciences><brain tissue><clinical applicability><clinical application><clinical test><cohort><computerized data processing><cost><dark matter><data acquisition><data acquisitions><data analysis pipeline><data interpretation><data processing><data processing pipeline><data to train><dataset to train><deep learning><deep learning method><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><drug intervention><drug treatment><drug/agent><early biomarkers><early detection biomarkers><early detection markers><early screening><hemodynamics><high risk><image construction><image generation><image reconstruction><imaging><imaging approach><imaging based approach><imaging system><improved><in vivo><indexing><innovate><innovation><innovative><magnetic field><measurable outcome><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><neuropathologic><neuropathological><neuropathology><novel><outcome measurement><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><physical model><pre-clinical><preclinical><prevent><preventing><primary degenerative dementia><reconstruction><research clinical testing><resection><resolutions><senile dementia of the Alzheimer type><sex><structural imaging><test for Alzheimer><three dimensional><tool><training data>

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Adrian Lynn Oblak

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$660,563

FY 2026

Project Title

The Role of Aspergillus versicolor and the Th2 Lung-Brain Axis in Alzheimer's Disease-like Neuropathology

Grant Number:

5R01AG076142-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Alzheimer’s disease (AD) is the most prevalent neurodegenerative disease and the leading cause of dementia in the elderly. Available AD treatment is unable to halt disease progression, highlighting the urgent need to identify the potential etiology and pathobiology driving AD. The ro...

Research Terms

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ADAM C PUCHE

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$649,766

FY 2026

Project Title

HCN Channels Mediate Olfactory Dysfunction in Aging and Neurological Disease

Grant Number:

1R01AG092405-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Olfaction frequently declines during aging and in neurological diseases including Alzheimer’s disease. Hyperpolarization- activated cyclic nucleotide-gated cation (HCN) channels (isoforms 1-4) generate the Ih conductance, playing controlling roles in neuronal excitability an...

Research Terms

<21+ years old><AD dementia><AD model><Adult><Adult Human><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimers Dementia><Animal Disease Models><Animal Model><Animal Models and Related Studies><BCNG1><Behavior><Behavioral><Body Tissues><Brain Cyclic-Nucleotide Gated 1><Calcium><Categories><Cations><Cell Body><Cells><Characteristics><Cognitive><Cognitive deficits><Connector Neuron><Cyclic Nucleotides><Cyclicity><Data><Degenerative Neurologic Disorders><Disease><Disorder><Down-Regulation><Dysfunction><Electrophysiology><Electrophysiology (science)><Elements><Exhibits><Functional disorder><Genes><Genetic><HCN1><HCN1 gene><HCN4><HCN4 gene><Health><Hyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 1><Hyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 4><Image><Impairment><In Vitro><Individual><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Investigation><Isoforms><Link><Maps><Mediating><Messenger RNA><Mice><Mice Mammals><Molecular><Morphology><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Disorders><Neurons><Neurophysiology / Electrophysiology><Odors><Olfaction><Olfactory Pathways><Olfactory dysfunction><Olfactory system><Output><Pace Stimulators><Pacemakers><Pattern><Performance><Periodicals><Periodicity><Phenotype><Physiopathology><Play><Potassium Channel, Voltage-Gated, Brain, 1><Primary Senile Degenerative Dementia><Protein Isoforms><Proteins><Regulation><Rejuvenation><Reporting><Rhythmicity><Role><Sensory><Smell><Smell Perception><Subgroup><Testing><Tissues><Upregulation><Viral><adult youth><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged brain><ages><aging brain><alzheimer model><antagonism><antagonist><cell type><cognitive defects><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><electrophysiological><excitatory neuron><experiment><experimental research><experimental study><experiments><familial AD><familial Alzheimer><familial Alzheimer disease><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><imaging><in vivo><juvenile animal><knock-down><knockdown><mRNA><mitral cell><model of animal><multi-photon><natural aging><neural><neural network><neurodegenerative illness><neurological disease><neuronal><neuronal excitability><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><normal aging><normative aging><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><odor perception><olfactory bulb><olfactory circuitry><olfactory circuits><olfactory impairment><olfactory perception><overexpress><overexpression><pathophysiology><periodic><periodical><pharmacologic><primary degenerative dementia><protein expression><restoration><selective expression><selectively expressed><senile dementia of the Alzheimer type><social role><therapeutic target><young adult><young adult age><young adulthood><young animal><younger age>

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Fuwen Zhou

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$649,766

FY 2026

Project Title

HCN Channels Mediate Olfactory Dysfunction in Aging and Neurological Disease

Grant Number:

1R01AG092405-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Olfaction frequently declines during aging and in neurological diseases including Alzheimer’s disease. Hyperpolarization- activated cyclic nucleotide-gated cation (HCN) channels (isoforms 1-4) generate the Ih conductance, playing controlling roles in neuronal excitability an...

Research Terms

<21+ years old><AD dementia><AD model><Adult><Adult Human><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimers Dementia><Animal Disease Models><Animal Model><Animal Models and Related Studies><BCNG1><Behavior><Behavioral><Body Tissues><Brain Cyclic-Nucleotide Gated 1><Calcium><Categories><Cations><Cell Body><Cells><Characteristics><Cognitive><Cognitive deficits><Connector Neuron><Cyclic Nucleotides><Cyclicity><Data><Degenerative Neurologic Disorders><Disease><Disorder><Down-Regulation><Dysfunction><Electrophysiology><Electrophysiology (science)><Elements><Exhibits><Functional disorder><Genes><Genetic><HCN1><HCN1 gene><HCN4><HCN4 gene><Health><Hyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 1><Hyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 4><Image><Impairment><In Vitro><Individual><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Investigation><Isoforms><Link><Maps><Mediating><Messenger RNA><Mice><Mice Mammals><Molecular><Morphology><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Disorders><Neurons><Neurophysiology / Electrophysiology><Odors><Olfaction><Olfactory Pathways><Olfactory dysfunction><Olfactory system><Output><Pace Stimulators><Pacemakers><Pattern><Performance><Periodicals><Periodicity><Phenotype><Physiopathology><Play><Potassium Channel, Voltage-Gated, Brain, 1><Primary Senile Degenerative Dementia><Protein Isoforms><Proteins><Regulation><Rejuvenation><Reporting><Rhythmicity><Role><Sensory><Smell><Smell Perception><Subgroup><Testing><Tissues><Upregulation><Viral><adult youth><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged brain><ages><aging brain><alzheimer model><antagonism><antagonist><cell type><cognitive defects><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><electrophysiological><excitatory neuron><experiment><experimental research><experimental study><experiments><familial AD><familial Alzheimer><familial Alzheimer disease><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><imaging><in vivo><juvenile animal><knock-down><knockdown><mRNA><mitral cell><model of animal><multi-photon><natural aging><neural><neural network><neurodegenerative illness><neurological disease><neuronal><neuronal excitability><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><normal aging><normative aging><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><odor perception><olfactory bulb><olfactory circuitry><olfactory circuits><olfactory impairment><olfactory perception><overexpress><overexpression><pathophysiology><periodic><periodical><pharmacologic><primary degenerative dementia><protein expression><restoration><selective expression><selectively expressed><senile dementia of the Alzheimer type><social role><therapeutic target><young adult><young adult age><young adulthood><young animal><younger age>

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Michael G Anderson

UNIVERSITY OF IOWA, IOWA CITY, IA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$625,485

FY 2026

Project Title

Foundational Biology of Glaucoma GWAS Loci

Grant Number:

5R01EY035679-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons. Damage from glaucoma is permanent and may cause irreversible blindness. Glaucoma is a major public health problem in the United States and worldwide, where it is the leading cause...

Research Terms

<17q21><AD dementia><APP gene><Affect><Age><Alleles><Allelomorphs><Alzheimer Disease 1 Protein><Alzheimer Disease Protease Nexin-II><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease Amyloid Protein><Alzheimer's amyloid><Alzheimers Dementia><Amyloid><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta A4 Precursor Protein><Amyloid Beta A4 Protein Precursor><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid of Aging and Alzheimer Disease Protein><Amyloid β><Amyloid β A4 Protein Precursor><Amyloid β-Peptide><Amyloid β-Protein><Assay><Axon><Aβ><Binding Proteins><Bioassay><Biological><Biological Assay><Biology><Bite><Blindness><Body Tissues><Brain><Brain Nervous System><Candidate Disease Gene><Candidate Gene><Caring><Cell Body><Cell Survival><Cell Viability><Cells><Cerebralvascular Amyloid Peptide><Chromosomes><Code><Coding System><Compensated Glaucoma><Compensative Glaucoma><Complex><Cranial Nerve II><DNA><DNA mutation><Data><Degenerative Neurologic Disorders><Deoxyribonucleic Acid><Development><Disease><Disorder><Dysfunction><ELISA><Encephalon><Enhancers><Enzyme-Linked Immunosorbent Assay><Ethnic Origin><Ethnicity><Exons><Eye><Eyeball><Family><Family Medical History><Family Medical History Epidemiology><Family history of><Functional disorder><GWA study><GWAS><Ganglia><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Risk><Genetic Transcription><Genetic defect><Genetic mutation><Genetic predisposing factor><Genome><Genotype><Glaucoma><Glaucoma Simplex><Goals><Health><Heritability><History><Human><Intraocular Pressure><Knowledge><Ligand Binding Protein><Ligand Binding Protein Gene><Link><MT-bound tau><Maps><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Mutation><Nerve Degeneration><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural Ganglion><Neural degenerative Disorders><Neuritic Plaques><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurofibrillary Tangles><Neurologic Degenerative Conditions><Neuron Degeneration><Ocular Hypertension><Ocular Tension><Open-Angle Glaucoma><Optic Nerve><POAG><Pathogenesis><Pathway interactions><Patients><Physiologic Intraocular Pressure><Physiopathology><PreA4><Primary Open Angle Glaucoma><Primary Senile Degenerative Dementia><Protease Nexin II><Protein Binding><Protein Precursors><Proteins><Public Health><RNA Expression><Race><Races><Recording of previous events><Reporter><Research><Retina><Retinal Diseases><Retinal Disorder><Retinal Ganglion Cells><Risk><Risk Factors><Risk-associated variant><Role><Second Cranial Nerve><Selection Criteria><Senile Plaques><Serotyping><Sight><Simple Glaucoma><Single Base Polymorphism><Single Nucleotide Polymorphism><Source><Specificity><Testing><Therapeutic Intervention><Tissues><Transcript><Transcription><Translating><United States><Variant><Variation><Virus><Vision><a beta peptide><abeta><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age group><age related neurodegeneration><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><ages><aging associated neurodegeneration><aging associated neurodegenerative disease><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><amyloid beta><amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) protein, human><amyloid beta plaque><amyloid-b plaque><amyloid-b protein><aβ plaques><beta amyloid fibril><biologic><bound protein><cored plaque><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diffuse plaque><disease risk><disorder risk><effective therapy><effective treatment><enzyme linked immunoassay><experiment><experimental research><experimental study><experiments><gene locus><genetic locus><genetic risk factor><genome mutation><genome wide analysis><genome wide association><genome wide association scan><genome wide association study><genome wide studies><genome-wide analysis><genome-wide identification><genomewide association scan><genomewide association study><genomic location><genomic locus><glaucomatous><high risk><histories><human protease nexin 2><inherited factor><insight><intervention therapy><intra-ocular pressure><member><microtubule bound tau><microtubule-bound tau><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurological degeneration><neuronal degeneration><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><ocular hypertensive><pathophysiology><pathway><prevent><preventing><primary degenerative dementia><promoter><promotor><protease nexin 2><protein structure><protein structures><proteins structure><public health relevance><racial><racial background><racial origin><retina disease><retina disorder><retinal ganglion><retinopathy><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single nucleotide variant><single-cell RNA sequencing><social role><soluble amyloid precursor protein><tangle><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau factor><transcriptomics><vision loss><visual function><visual loss><whole genome association analysis><whole genome association study><τ Proteins>

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JOHN H FINGERT

UNIVERSITY OF IOWA, IOWA CITY, IA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$625,485

FY 2026

Project Title

Foundational Biology of Glaucoma GWAS Loci

Grant Number:

5R01EY035679-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons. Damage from glaucoma is permanent and may cause irreversible blindness. Glaucoma is a major public health problem in the United States and worldwide, where it is the leading cause...

Research Terms

<17q21><AD dementia><APP gene><Affect><Age><Alleles><Allelomorphs><Alzheimer Disease 1 Protein><Alzheimer Disease Protease Nexin-II><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease Amyloid Protein><Alzheimer's amyloid><Alzheimers Dementia><Amyloid><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta A4 Precursor Protein><Amyloid Beta A4 Protein Precursor><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid of Aging and Alzheimer Disease Protein><Amyloid β><Amyloid β A4 Protein Precursor><Amyloid β-Peptide><Amyloid β-Protein><Assay><Axon><Aβ><Binding Proteins><Bioassay><Biological><Biological Assay><Biology><Bite><Blindness><Body Tissues><Brain><Brain Nervous System><Candidate Disease Gene><Candidate Gene><Caring><Cell Body><Cell Survival><Cell Viability><Cells><Cerebralvascular Amyloid Peptide><Chromosomes><Code><Coding System><Compensated Glaucoma><Compensative Glaucoma><Complex><Cranial Nerve II><DNA><DNA mutation><Data><Degenerative Neurologic Disorders><Deoxyribonucleic Acid><Development><Disease><Disorder><Dysfunction><ELISA><Encephalon><Enhancers><Enzyme-Linked Immunosorbent Assay><Ethnic Origin><Ethnicity><Exons><Eye><Eyeball><Family><Family Medical History><Family Medical History Epidemiology><Family history of><Functional disorder><GWA study><GWAS><Ganglia><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Risk><Genetic Transcription><Genetic defect><Genetic mutation><Genetic predisposing factor><Genome><Genotype><Glaucoma><Glaucoma Simplex><Goals><Health><Heritability><History><Human><Intraocular Pressure><Knowledge><Ligand Binding Protein><Ligand Binding Protein Gene><Link><MT-bound tau><Maps><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Mutation><Nerve Degeneration><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural Ganglion><Neural degenerative Disorders><Neuritic Plaques><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurofibrillary Tangles><Neurologic Degenerative Conditions><Neuron Degeneration><Ocular Hypertension><Ocular Tension><Open-Angle Glaucoma><Optic Nerve><POAG><Pathogenesis><Pathway interactions><Patients><Physiologic Intraocular Pressure><Physiopathology><PreA4><Primary Open Angle Glaucoma><Primary Senile Degenerative Dementia><Protease Nexin II><Protein Binding><Protein Precursors><Proteins><Public Health><RNA Expression><Race><Races><Recording of previous events><Reporter><Research><Retina><Retinal Diseases><Retinal Disorder><Retinal Ganglion Cells><Risk><Risk Factors><Risk-associated variant><Role><Second Cranial Nerve><Selection Criteria><Senile Plaques><Serotyping><Sight><Simple Glaucoma><Single Base Polymorphism><Single Nucleotide Polymorphism><Source><Specificity><Testing><Therapeutic Intervention><Tissues><Transcript><Transcription><Translating><United States><Variant><Variation><Virus><Vision><a beta peptide><abeta><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age group><age related neurodegeneration><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><ages><aging associated neurodegeneration><aging associated neurodegenerative disease><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><amyloid beta><amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) protein, human><amyloid beta plaque><amyloid-b plaque><amyloid-b protein><aβ plaques><beta amyloid fibril><biologic><bound protein><cored plaque><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diffuse plaque><disease risk><disorder risk><effective therapy><effective treatment><enzyme linked immunoassay><experiment><experimental research><experimental study><experiments><gene locus><genetic locus><genetic risk factor><genome mutation><genome wide analysis><genome wide association><genome wide association scan><genome wide association study><genome wide studies><genome-wide analysis><genome-wide identification><genomewide association scan><genomewide association study><genomic location><genomic locus><glaucomatous><high risk><histories><human protease nexin 2><inherited factor><insight><intervention therapy><intra-ocular pressure><member><microtubule bound tau><microtubule-bound tau><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurological degeneration><neuronal degeneration><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><ocular hypertensive><pathophysiology><pathway><prevent><preventing><primary degenerative dementia><promoter><promotor><protease nexin 2><protein structure><protein structures><proteins structure><public health relevance><racial><racial background><racial origin><retina disease><retina disorder><retinal ganglion><retinopathy><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single nucleotide variant><single-cell RNA sequencing><social role><soluble amyloid precursor protein><tangle><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau factor><transcriptomics><vision loss><visual function><visual loss><whole genome association analysis><whole genome association study><τ Proteins>

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TODD E SCHEETZ

UNIVERSITY OF IOWA, IOWA CITY, IA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$625,485

FY 2026

Project Title

Foundational Biology of Glaucoma GWAS Loci

Grant Number:

5R01EY035679-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract Glaucoma is a neurodegenerative disease characterized by loss of retinal ganglion cells (RGCs) and their axons. Damage from glaucoma is permanent and may cause irreversible blindness. Glaucoma is a major public health problem in the United States and worldwide, where it is the leading cause...

Research Terms

<17q21><AD dementia><APP gene><Affect><Age><Alleles><Allelomorphs><Alzheimer Disease 1 Protein><Alzheimer Disease Protease Nexin-II><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease Amyloid Protein><Alzheimer's amyloid><Alzheimers Dementia><Amyloid><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta A4 Precursor Protein><Amyloid Beta A4 Protein Precursor><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid of Aging and Alzheimer Disease Protein><Amyloid β><Amyloid β A4 Protein Precursor><Amyloid β-Peptide><Amyloid β-Protein><Assay><Axon><Aβ><Binding Proteins><Bioassay><Biological><Biological Assay><Biology><Bite><Blindness><Body Tissues><Brain><Brain Nervous System><Candidate Disease Gene><Candidate Gene><Caring><Cell Body><Cell Survival><Cell Viability><Cells><Cerebralvascular Amyloid Peptide><Chromosomes><Code><Coding System><Compensated Glaucoma><Compensative Glaucoma><Complex><Cranial Nerve II><DNA><DNA mutation><Data><Degenerative Neurologic Disorders><Deoxyribonucleic Acid><Development><Disease><Disorder><Dysfunction><ELISA><Encephalon><Enhancers><Enzyme-Linked Immunosorbent Assay><Ethnic Origin><Ethnicity><Exons><Eye><Eyeball><Family><Family Medical History><Family Medical History Epidemiology><Family history of><Functional disorder><GWA study><GWAS><Ganglia><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Risk><Genetic Transcription><Genetic defect><Genetic mutation><Genetic predisposing factor><Genome><Genotype><Glaucoma><Glaucoma Simplex><Goals><Health><Heritability><History><Human><Intraocular Pressure><Knowledge><Ligand Binding Protein><Ligand Binding Protein Gene><Link><MT-bound tau><Maps><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Mutation><Nerve Degeneration><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural Ganglion><Neural degenerative Disorders><Neuritic Plaques><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurofibrillary Tangles><Neurologic Degenerative Conditions><Neuron Degeneration><Ocular Hypertension><Ocular Tension><Open-Angle Glaucoma><Optic Nerve><POAG><Pathogenesis><Pathway interactions><Patients><Physiologic Intraocular Pressure><Physiopathology><PreA4><Primary Open Angle Glaucoma><Primary Senile Degenerative Dementia><Protease Nexin II><Protein Binding><Protein Precursors><Proteins><Public Health><RNA Expression><Race><Races><Recording of previous events><Reporter><Research><Retina><Retinal Diseases><Retinal Disorder><Retinal Ganglion Cells><Risk><Risk Factors><Risk-associated variant><Role><Second Cranial Nerve><Selection Criteria><Senile Plaques><Serotyping><Sight><Simple Glaucoma><Single Base Polymorphism><Single Nucleotide Polymorphism><Source><Specificity><Testing><Therapeutic Intervention><Tissues><Transcript><Transcription><Translating><United States><Variant><Variation><Virus><Vision><a beta peptide><abeta><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age group><age related neurodegeneration><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><ages><aging associated neurodegeneration><aging associated neurodegenerative disease><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><amyloid beta><amyloid beta (A4) precursor protein (protease nexin-II, Alzheimer disease) protein, human><amyloid beta plaque><amyloid-b plaque><amyloid-b protein><aβ plaques><beta amyloid fibril><biologic><bound protein><cored plaque><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diffuse plaque><disease risk><disorder risk><effective therapy><effective treatment><enzyme linked immunoassay><experiment><experimental research><experimental study><experiments><gene locus><genetic locus><genetic risk factor><genome mutation><genome wide analysis><genome wide association><genome wide association scan><genome wide association study><genome wide studies><genome-wide analysis><genome-wide identification><genomewide association scan><genomewide association study><genomic location><genomic locus><glaucomatous><high risk><histories><human protease nexin 2><inherited factor><insight><intervention therapy><intra-ocular pressure><member><microtubule bound tau><microtubule-bound tau><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurological degeneration><neuronal degeneration><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><ocular hypertensive><pathophysiology><pathway><prevent><preventing><primary degenerative dementia><promoter><promotor><protease nexin 2><protein structure><protein structures><proteins structure><public health relevance><racial><racial background><racial origin><retina disease><retina disorder><retinal ganglion><retinopathy><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single nucleotide variant><single-cell RNA sequencing><social role><soluble amyloid precursor protein><tangle><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau factor><transcriptomics><vision loss><visual function><visual loss><whole genome association analysis><whole genome association study><τ Proteins>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Wei Pan

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$623,571

FY 2026

Project Title

Estimation and inference in directed acyclic graphical models for biological networks

Grant Number:

5R01AG074858-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary As biotechnology advances, biomedical investigations have become more complex due to high-throughput and high-dimensional data collected at a genomic scale. Of paramount importance is unraveling the regulatory roles of genetic variants on genes and gene-to-gene regulatory relationships. On ...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

XIAOTONG Tom SHEN

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$623,571

FY 2026

Project Title

Estimation and inference in directed acyclic graphical models for biological networks

Grant Number:

5R01AG074858-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary As biotechnology advances, biomedical investigations have become more complex due to high-throughput and high-dimensional data collected at a genomic scale. Of paramount importance is unraveling the regulatory roles of genetic variants on genes and gene-to-gene regulatory relationships. On ...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Tamar Gollan

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$615,977

FY 2026

Project Title

Language Switching with Alzheimer's Disease

Grant Number:

5R01AG076415-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2022

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

We propose a series of studies that apply a cognitive neuropsychological approach to investigate the behavioral presentation of Alzheimer’s disease (AD) in Spanish-English bilinguals. We use models of bilingual language processing and cognitive decline in AD to motivate experimental manipulations th...

Research Terms

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KEVIN M DUFF

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$607,706

FY 2026

Project Title

Short-term practice effects in Subjective Cognitive Decline: Moderators, prognostic value, and relationship to biomarker status

Grant Number:

1R01AG099149-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Subjective cognitive decline (SCD), or self-reported persistent changes in cognitive capacity without the presence of objective cognitive impairments, is regarded as the first manifestation of preclinical or asymptomatic Alzheimer’s disease (AD) – falling between normal cogn...

Research Terms

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Dustin Hammers

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$607,706

FY 2026

Project Title

Short-term practice effects in Subjective Cognitive Decline: Moderators, prognostic value, and relationship to biomarker status

Grant Number:

1R01AG099149-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Subjective cognitive decline (SCD), or self-reported persistent changes in cognitive capacity without the presence of objective cognitive impairments, is regarded as the first manifestation of preclinical or asymptomatic Alzheimer’s disease (AD) – falling between normal cogn...

Research Terms

View Full Project Details on NIH Reporter

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John R Lukens

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$590,989

FY 2026

Project Title

Making a case for CASS4 in Alzheimer's disease

Grant Number:

5R01AG087406-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Recent genome-wide association studies (GWAS) have consistently linked mutations in CASS4 (Cas Scaffold Protein Family Member 4) to an increased risk of developing late-onset Alzheimer’s disease. Yet, very little is currently known about the role of CASS4 in basic neurobiology or neurodegen...

Research Terms

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Jason Neil MacLean

UNIVERSITY OF CHICAGO, CHICAGO, IL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$584,759

FY 2026

Project Title

Thalamocortical interactions

Grant Number:

5R01NS094184-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The proposed research will test related hypotheses that thalamus plays a heretofore neglected and critical role in cortical processing. In particular, many thalamic nuclei, that together comprise the majority of thalamic volume and that were previously mysterious in function, we now suggest are crit...

Research Terms

<2-photon><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD dementia><Abbreviations><Acetylcholine><Address><Adeno-Associated Viruses><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Aminalon><Aminalone><Anatomic Sites><Anatomic structures><Anatomy><Area><Back><Behavioral><Binding><Biologic Models><Biological Models><Brain><Brain Nervous System><Cell Body><Cell Nucleus><Cells><Cognitive Discrimination><Cognitive deficits><Control Animal><Data><Dependoparvovirus><Dependovirus><Detection><Discrimination><Dorsal><Dorsum><EPSP><Electrodes><Electrophysiology><Electrophysiology (science)><Encephalon><Excitatory Postsynaptic Potentials><Explosion><Feedback><Fluorescence><Future><GABA><Generations><Geniculate Bodies><Geniculate body structure><Glutamates><Image><Immediate Memory><In Vitro><L-Glutamate><Label><Lateral Geniculate Body><Maps><Medial><Metabotropic Glutamate Receptors><Metathalamus><Mice><Mice Mammals><Model System><Modeling><Molecular Interaction><Monitor><Motor Cortex><Murine><Mus><Nerve><Nerve Cells><Nerve Unit><Network Analysis><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nucleus><Pathway Analysis><Pathway interactions><Pattern><Peripheral><Phase><Physiology><Play><Preparation><Primary Senile Degenerative Dementia><Progress Reports><Property><Pulvinar><Pulvinar structure><Research><Role><Route><Schizophrenia><Schizophrenic Disorders><Sensory><Short-Term Memory><Slice><Source><Spinal><Stimulus><Synapses><Synaptic><Synaptic Potentials><System><Tactile><Techniques><Testing><Thalamic Nuclei><Thalamic structure><Thalamus><Transmission><adeno associated virus group><barrel cortex><behavior test><behavioral test><cognitive defects><cognitive function><dementia praecox><density><electrophysiological><experiment><experimental research><experimental study><experiments><gamma-Aminobutyric Acid><geniculate nucleus><glutamatergic><imaging><in vivo><interest><lateral geniculate><lateral geniculate nucleus><neglect><neuronal><pathway><postsynaptic><preparations><primary degenerative dementia><programs><pulvinar thalami><redshift><response><schizophrenic><senile dementia of the Alzheimer type><sensory cortex><sensory input><social role><somatosensory><synapse><thalamic><transmission process><two-photon><working memory><γ-Aminobutyric Acid>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

S. Murray SHERMAN

UNIVERSITY OF CHICAGO, CHICAGO, IL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$584,759

FY 2026

Project Title

Thalamocortical interactions

Grant Number:

5R01NS094184-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The proposed research will test related hypotheses that thalamus plays a heretofore neglected and critical role in cortical processing. In particular, many thalamic nuclei, that together comprise the majority of thalamic volume and that were previously mysterious in function, we now suggest are crit...

Research Terms

<2-photon><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD dementia><Abbreviations><Acetylcholine><Address><Adeno-Associated Viruses><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Aminalon><Aminalone><Anatomic Sites><Anatomic structures><Anatomy><Area><Back><Behavioral><Binding><Biologic Models><Biological Models><Brain><Brain Nervous System><Cell Body><Cell Nucleus><Cells><Cognitive Discrimination><Cognitive deficits><Control Animal><Data><Dependoparvovirus><Dependovirus><Detection><Discrimination><Dorsal><Dorsum><EPSP><Electrodes><Electrophysiology><Electrophysiology (science)><Encephalon><Excitatory Postsynaptic Potentials><Explosion><Feedback><Fluorescence><Future><GABA><Generations><Geniculate Bodies><Geniculate body structure><Glutamates><Image><Immediate Memory><In Vitro><L-Glutamate><Label><Lateral Geniculate Body><Maps><Medial><Metabotropic Glutamate Receptors><Metathalamus><Mice><Mice Mammals><Model System><Modeling><Molecular Interaction><Monitor><Motor Cortex><Murine><Mus><Nerve><Nerve Cells><Nerve Unit><Network Analysis><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nucleus><Pathway Analysis><Pathway interactions><Pattern><Peripheral><Phase><Physiology><Play><Preparation><Primary Senile Degenerative Dementia><Progress Reports><Property><Pulvinar><Pulvinar structure><Research><Role><Route><Schizophrenia><Schizophrenic Disorders><Sensory><Short-Term Memory><Slice><Source><Spinal><Stimulus><Synapses><Synaptic><Synaptic Potentials><System><Tactile><Techniques><Testing><Thalamic Nuclei><Thalamic structure><Thalamus><Transmission><adeno associated virus group><barrel cortex><behavior test><behavioral test><cognitive defects><cognitive function><dementia praecox><density><electrophysiological><experiment><experimental research><experimental study><experiments><gamma-Aminobutyric Acid><geniculate nucleus><glutamatergic><imaging><in vivo><interest><lateral geniculate><lateral geniculate nucleus><neglect><neuronal><pathway><postsynaptic><preparations><primary degenerative dementia><programs><pulvinar thalami><redshift><response><schizophrenic><senile dementia of the Alzheimer type><sensory cortex><sensory input><social role><somatosensory><synapse><thalamic><transmission process><two-photon><working memory><γ-Aminobutyric Acid>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Stephanie Anne-Carine Debette

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$578,469

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S4

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Carole Dufouil

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$578,469

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S4

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Mohammad Arfan Ikram

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$578,469

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S4

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Claudia L Satizabal

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$578,469

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S4

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Sudha Seshadri

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$578,469

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S4

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Astrid M Suchy-Dicey

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$578,469

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S4

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Paul S Garcia

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$577,122

FY 2026

Project Title

EEG-guided analgesic titration during general anesthesia to improve early neurocognitive recovery in older patients

Grant Number:

1R01AG093122-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY We intend to improve brain health in elderly patients undergoing surgery by EEG-guided optimization of pharmacologic decision-making during anesthesia. Alzheimer's disease (AD), the most common form of dementia, frequently co-occurs with surgery in this population. A significant conc...

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Jeannette R. Mahoney

STATE UNIVERSITY NEW YORK STONY BROOK, STONY BROOK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$568,696

FY 2026

Project Title

Visual-somatosensory integration as a novel marker of Alzheimer's disease

Grant Number:

5R01AG075679-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Identification of novel, non-cognitive (i.e., sensory or motor), non-invasive markers of Alzheimer’s disease and related dementias are a national priority identified by the National Alzheimer Plan. Growing evidence suggests that Alzheimer’s pathology manifests in sensory association areas w...

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Yuhua Song

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$564,154

FY 2026

Project Title

Drugs repositioning to target TREM2 in Alzheimer disease

Grant Number:

5R01AG081228-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Single amino acid variants in TREM2 have been identified by genome-wide association studies to be one of the strongest genetic risk factors for late-onset Alzheimer's disease (AD). AD-associated variants in TREM2 impair TREM2's ability to bind and signal in response to ligands in the body, further a...

Research Terms

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Seong Su Kang

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$559,052

FY 2026

Project Title

Impact of APOE4 on sex-specific mechanism for Alzheimer's disease

Grant Number:

5R01AG087190-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Even though so many risk factors and the related hypotheses for Alzheimer’s disease (AD) have been proposed, the exact disease-modifying therapies have not been established. The female predominance in the development of AD also has been well demonstrated as a risk factor. Therefore, understanding se...

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Qingyun Li

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$553,216

FY 2026

Project Title

Dissecting the origin, regulation and function of microglial subsets in Alzheimer's disease

Grant Number:

5R01AG078512-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Recent advances in human genetics have unequivocally demonstrated mutations in microglia-specific genes, such as TREM2 R47H, to be some of the strongest risk factors for late-onset Alzheimer’s disease (AD). These breakthroughs point to microglia as a potential driver for AD pathology...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD and related dementia><AD dementia><AD model><AD pathology><AD pathway><AD patients><AD related dementia><AD risk><AD risk factor><AD therapy><AD treatment><AD-associated pathways><AD-related pathways><AD-specific pathways><ADRD><APOE><Adult><Adult Human><Affect><Aged 65 and Over><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer disease treatment><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease model><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's mechanism><Alzheimer's pathology><Alzheimer's patient><Alzheimer's related pathways><Alzheimer's therapy><Alzheimers Dementia><American><Amyloid (Aβ) plaques><Amyloid Plaques><Amyloidosis><Apo-E><ApoE protein><Apolipoprotein E><Basal Transcription Factor><Basal transcription factor genes><Bioinformatics><Brain><Brain Nervous System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Corynebacterium Diphtheriae Toxin><DNA mutation><Degenerative Neurologic Disorders><Deposit><Deposition><Development><Diphtheria Toxin><Disease><Disease Progression><Disease associated microglia><Disorder><Drug resistance><Elements><Encephalon><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><Gene Alteration><Gene Expression><Gene Modified><Gene Mutation><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Change><Genetic Markers><Genetic Transcription><Genetic defect><Genetic mutation><Goals><Heterogeneity><Hortega cell><Human><Human Genetics><Immune><Immunes><Immunity><In Vitro><Intervention><Intracellular Communication and Signaling><Knock-out><Knockout><Knowledge><Late Onset Alzheimer Disease><Late onset AD><Link><Maps><Memory><Mice><Mice Mammals><Microglia><Modern Man><Molecular><Murine><Mus><Mutation><Names><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neuritic Plaques><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Pathologic><Phenotype><Primary Senile Degenerative Dementia><RNA Expression><Regulation><Research><Risk Factors><Role><Senile Plaques><Signal Transduction><Signal Transduction Systems><Signaling><TREM2><TREM2 gene><Testing><Training><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Transplant-Related Disorder><Transplantation><Triggering Receptor Expressed in Myeloid Cells 2><Triggering Receptor Expressed on Myeloid Cells 2><above age 65><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><alzheimer model><alzheimer risk><amyloid beta plaque><amyloid disease><amyloid pathology><amyloid-b plaque><aβ plaques><biological signal transduction><cohort><cored plaque><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diffuse plaque><disease control><disorder control><drug resistant><epigenetic memory><epigenetic profiling><epigenetically><gene biomarker><gene defect><gene expression biomarker><gene locus><gene marker><gene modification><gene signature biomarker><gene signatures><genetic biomarker><genetic locus><genetic signature><genetically modified><genome mutation><genomic location><genomic locus><gitter cell><glial activation><glial cell activation><human old age (65+)><in vivo><insight><late onset alzheimer><later in life><later life><mechanisms in AD><mechanisms in Alzheimer's disease><mesoglia><microglial cell><microgliocyte><mouse model><murine model><mutant><mutant allele><name><named><naming><neurodegenerative illness><neuroprotection><neuroprotective><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><over 65 years><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><perivascular glial cell><postnatal><primary degenerative dementia><resistance to Drug><resistant to Drug><response><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><substantia alba><theories><transcription factor><transcriptomics><transplant><transplant disease><white matter><≥65 years>

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Masashi Kitazawa

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$537,718

FY 2026

Project Title

Microglia dysregulation and SYK signaling in Alzheimer's disease

Grant Number:

4R01AG078201-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Alzheimer's disease (AD) is the most prevalent neurodegenerative disease with dementia among the elderly, yet exact causes of the disease and underlying pathogenic mechanisms that lead to development of effective therapeutic interventions have not been identified. Recently, ...

Research Terms

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Jae-eun Kang Miller

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$529,744

FY 2026

Project Title

Unraveling a Vicious Cycle: Entorhinal Cortex Hyperactivity, Neuroinflammation, and the Progression of Tauopathy

Grant Number:

1R01AG086475-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The entorhinal cortex (EC) is ground zero for Alzheimer’s disease (AD), showing early signs of tauopathy and neuroinflammation, which then spread through the entorhinal-hippocampal (EC-HPC) circuit. There are major gaps in knowledge regarding why the EC is vulnerable early in AD, an...

Research Terms

<2-photon><2-photon microscopy><AD dementia><AD pathology><Acceleration><Acute><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease pathology><Alzheimer's pathology><Alzheimers Dementia><Ammon Horn><Brain><Brain Nervous System><Chronic><Cornu Ammonis><Disease><Disease Progression><Disorder><Elements><Encephalon><Entorhinal Area><Epilepsy><Epileptic Seizures><Epileptics><Genetic><Hippocampus><Hortega cell><Human><Hyperactivity><Image><Immunosuppressants><Immunosuppressive Agents><Immunosuppressive drug><Immunosuppressive treatment><Intervention><Knowledge><Link><MT-bound tau><Measures><Microglia><Modeling><Modern Man><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Primary Senile Degenerative Dementia><Proteins><Role><Seizure Disorder><Tacrolimus><Tauopathies><Testing><Time><Work><cytokine><entorhinal cortex><epilepsia><epileptogenic><gitter cell><glial activation><glial cell activation><hippocampal><imaging><immune suppressive agent><immune suppressor><immunosuppressive substance><immunosuppressor><in vivo><inhibitor><innovate><innovation><innovative><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><neural><neural inflammation><neuroinflammation><neuroinflammatory><neuronal><neuropathologic tau><neuropathological tau><novel><perivascular glial cell><primary degenerative dementia><senile dementia of the Alzheimer type><social role><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><two photon excitation microscopy><two photon microscopy><two-photon><τ Proteins>

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Zhiliang Wei

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$520,215

FY 2026

Project Title

Pathophysiological mechanisms of hypoperfusion in mouse models of Alzheimer?s disease and small vessel disease

Grant Number:

5R01AG081932-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project summary/Abstract Hypoperfusion is broadly reported as an important symptom of Alzheimer’s disease related dementia (ADRD). Severity of cerebral blood flow (CBF) loss correlates with severity of cognitive deficit. However, hypoperfusion is only one of the signs of microvascular dysfunction i...

Research Terms

<(TNF)-α><AD and related dementia><AD dementia><AD model><AD related dementia><ADRD><Age><Air><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's amyloid><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease model><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Amyloidosis><Anatomic Sites><Anatomic structures><Anatomy><Animal Disease Models><Arterial Disorder><Arteriopathy><Aβ><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BBB permeabilization><BBB permeable><BCDF><BSF-2><BSF2><Behavior><Binswanger Disease><Binswanger Encephalopathy><Biological Markers><Blood - brain barrier anatomy><Blood Sample><Blood Vessels><Blood specimen><Blood-Brain Barrier><Brain><Brain Nervous System><Brain Vascular reactivity><CADASIL><Cachectin><Cell Density><Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts Leukoencephalopathy><Cerebrovascular Circulation><Cerebrum><Chronic Progressive Subcortical Encephalopathy><Clinical Trials><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Contrast Agent><Contrast Drugs><Contrast Media><Coupling><Cross-Sectional Studies><Cross-Sectional Survey><Data><Dementia><Disease Frequency Surveys><Disturbance in cognition><ELISA><Encephalon><Enzyme-Linked Immunosorbent Assay><Euthanasia><FDG PET><Funding><Genetic><Goals><HPGF><Hemato-Encephalic Barrier><Hepatocyte-Stimulating Factor><Histologic><Histologically><Histology><Human><Hybridoma Growth Factor><Hypercapnia><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impaired cognition><Interleukin-6><Intermediary Metabolism><Investigators><Leanness><Leiomyocyte><Link><Longitudinal Studies><Longitudinal Surveys><MGI-2><MR Imaging><MR Tomography><MRI><MRIs><Macrophage-Derived TNF><Magnetic Resonance Imaging><Measurement><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Memory><Mercy Killing><Metabolic><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Microvascular Dysfunction><Modeling><Modern Man><Monocyte-Derived TNF><Murine><Mus><Myeloid Differentiation-Inducing Protein><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Nature><Neuritic Plaques><Neurofibrillary Tangles><Nuclear Magnetic Resonance Imaging><O element><O2 element><Occluding Junctions><Oxygen><Participant><Pathology><Pattern><Perfusion><Physiologic><Physiological><Physiology><Plasmacytoma Growth Factor><Position><Positioning Attribute><Primary Senile Degenerative Dementia><Proteins><Radiopaque Media><Reporting><Reproducibility of Findings><Reproducibility of Results><Research><Research Design><Research Personnel><Researchers><Senile Plaques><Severities><Skull><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Study Type><Subcortical Arteriosclerotic Encephalopathy><Subcortical Infarctions><Subcortical Infarcts><Subcortical Leukoencephalopathy><Symptoms><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Tauopathies><Techniques><Testing><Therapeutic><Thinness><Tight Junctions><Time><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><United States National Institutes of Health><Vascular Smooth Muscle><Wild Type Mouse><Work><Zeugmatography><Zonula Occludens><a beta peptide><abeta><ages><alzheimer model><amyloid beta><amyloid beta plaque><amyloid disease><amyloid-b plaque><amyloid-b protein><autosome><aβ plaques><behavior outcome><behavior test><behavioral outcome><behavioral test><beta amyloid fibril><bio-markers><biologic marker><biomarker><blood flow in brain><blood-brain barrier permeabilization><blood-brain barrier permeable><bloodbrain barrier><bloodbrain barrier permeabilization><bloodbrain barrier permeable><brain blood circulation><brain blood flow><brain metabolism><candidate biomarker><candidate marker><carbon dioxide retention><cardiac disease induced cognitive impairment><cerebral><cerebral blood flow><cerebral circulation><cerebral vascular reactivity><cerebrocirculation><cerebrovascular blood flow><cerebrovascular contribution to cognitive impairment and dementia><cerebrovascular reactivity><cingulate cortex><cognitive defects><cognitive dysfunction><cognitive function><cognitive loss><cohort><cored plaque><cranium><cross-sectional research study><density><diffuse plaque><disease model><disorder model><elevated carbon dioxide><enzyme linked immunoassay><fluorodeoxyglucose PET><fluorodeoxyglucose positron emission tomography><glucose metabolism><hypercarbia><hypoperfusion><imaging><imaging study><in vivo><increased level Carbon dioxide><indexing><inflammation marker><inflammatory marker><interferon beta 2><long-term study><longitudinal outcome studies><longitudinal research study><metabolic rate><microvascular complications><microvascular disease><mouse model><murine model><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuropathologic tau><neuropathological tau><novel><object recognition><optic imaging><optical imaging><primary degenerative dementia><processing speed><senile dementia of the Alzheimer type><soluble amyloid precursor protein><study design><tangle><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><vascular><vascular cognitive impairment and dementia><vascular contribution to impairment or dementia><vascular contributions to cognition/dementia><vascular contributions to cognitive decline and dementia><vascular contributions to cognitive impairment and dementia><wildtype mouse>

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JAMES J KNIERIM

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$516,603

FY 2026

Project Title

Multisite analysis of hippocampal neuronal ensembles

Grant Number:

5R01NS039456-26

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/1999

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The hippocampus is a brain structure that is critical for normal learning and memory functions. One of the first brain regions to deteriorate in Alzheimer's Disease is the hippocampal memory system, causing the memory deficits that are among the first cognitive symptoms of the disea...

Research Terms

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Jingjing Yang

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$499,101

FY 2026

Project Title

Investigating Cis- and Trans-Genetic Regulation of Brain Transcriptomics and Proteomics Associated with AD/ADRD

Grant Number:

5R01AG089703-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Although genome-wide association studies (GWAS) have discovered ~75 significant risk genes associated with AD/ADRD, the underlying molecular mechanisms remain elusive. This gap has been partially filled by integrating different omics data together with GWAS data. For example, tools d...

Research Terms

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GREGORY C DEANGELIS

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$472,926

FY 2026

Project Title

Influences of viewing geometry on neural computations of motion and depth

Grant Number:

5R01EY013644-21

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Vision is active—we move our eyes to acquire information and to track objects of interest. However, eye movements have visual consequences; for example, when we smoothly move our eyes to pursue an object of interest, this adds components of motion to the retinal image. These visual consequences of e...

Research Terms

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WEI-JEN TANG

UNIVERSITY OF CHICAGO, CHICAGO, IL

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$470,385

FY 2026

Project Title

R35 Investigate structure and function of human amyloid-peptide degrading proteases

Grant Number:

1R35GM162573-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Abstract/Summary: Aggregates of amyloid peptides are highly cytotoxic and associated with human illnesses such as Alzheimer's disease, Parkinson's disease, and systemic amyloidoses (e.g., AL and AA amyloidosis). These toxic amyloid aggregates form through cross-β-sheet formation between amy...

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Matthias Arnold

DUKE UNIVERSITY, DURHAM, NC

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$452,943

FY 2026

Project Title

Metabolic age to define influences of the lipidome on brain aging in Alzheimer's disease

Grant Number:

5R01AG081322-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Evidence for the roles of lipids in brain aging and Alzheimer (AD) and its related dementias (ADRD) is building. Lipidomics is providing new insights related to altered lipid turnover and metabolism in AD and their roles in brain aging. Our AD Metabolomics Consortium (ADMC) led by MPI Kaddurah-Daouk...

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Rima F Kaddurah-Daouk

DUKE UNIVERSITY, DURHAM, NC

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$452,943

FY 2026

Project Title

Metabolic age to define influences of the lipidome on brain aging in Alzheimer's disease

Grant Number:

5R01AG081322-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Evidence for the roles of lipids in brain aging and Alzheimer (AD) and its related dementias (ADRD) is building. Lipidomics is providing new insights related to altered lipid turnover and metabolism in AD and their roles in brain aging. Our AD Metabolomics Consortium (ADMC) led by MPI Kaddurah-Daouk...

Research Terms

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PETER JOHN MEIKLE

DUKE UNIVERSITY, DURHAM, NC

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$452,943

FY 2026

Project Title

Metabolic age to define influences of the lipidome on brain aging in Alzheimer's disease

Grant Number:

5R01AG081322-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Evidence for the roles of lipids in brain aging and Alzheimer (AD) and its related dementias (ADRD) is building. Lipidomics is providing new insights related to altered lipid turnover and metabolism in AD and their roles in brain aging. Our AD Metabolomics Consortium (ADMC) led by MPI Kaddurah-Daouk...

Research Terms

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ANIL G CASHIKAR

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$445,870

FY 2026

Project Title

Role of the microglial immune-oxysterol 25-hydroxycholesterol in mediating neuroinflammation and neurodegeneration in the P301S tau transgenic mouse model of Alzheimer's disease

Grant Number:

5R01AG081419-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Alzheimer disease (AD) is the most common neurodegenerative disorder characterized by neuroinflammation associated with amyloid plaques and tau-containing neurofibrillary tangles in the brain as well as severe neurodegeneration, neuroinflammation and lipid accumulation. The ...

Research Terms

<25-hydroxycholesterol><AD and related dementia><AD dementia><AD model><AD related dementia><AD risk><AD risk factor><ADRD><APOE><APOE e3><APOE e4><APOE-ε4><APOEε4><Acceleration><Acute><Affect><Age><Agonist><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease model><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Ammon Horn><Amyloid><Amyloid (Aβ) plaques><Amyloid Plaques><Amyloid Substance><Apo-E><ApoE protein><Apolipoprotein E><Astrocytes><Astrocytus><Astroglia><Brain><Brain Nervous System><Cell Body><Cells><Cholesterol><Cholesterol Esters><Cholesterol Homeostasis><Cholesterol Synthesis Inhibition><Cholesteryl Esters><Co-culture><Cocultivation><Coculture><Coculture Techniques><Cornu Ammonis><Data><Degenerative Neurologic Disorders><Development><Disease associated microglia><Dysfunction><Encephalon><Enzyme Gene><Enzymes><Esterification><Female><Functional disorder><Gene Expression><Genes><Genetic predisposing factor><Genotype><Glia><Glial Cells><Hippocampus><Homolog of Drosophila TOLL><Hortega cell><Hydroxylases><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunes><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Inflammatory><Isoforms><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Lipids><Lipopolysaccharides><MT-bound tau><Measures><Mediating><Mediator><Mice><Mice Mammals><Microglia><Mixed Function Oxidases><Mixed Function Oxygenases><Monooxygenases><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuritic Plaques><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurofibrillary Tangles><Neuroglia><Neuroglial Cells><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Non-neuronal cell><Nonneuronal cell><Pathogenesis><Pathogenicity><Pathologic><Pathway interactions><Phagocytes><Phagocytic Cell><Phagocytosis><Physiopathology><Play><Primary Senile Degenerative Dementia><Production><Protein Isoforms><Reporting><Role><SRE-2 binding protein><SREBP-2><Senile Plaques><Single-Nucleus Sequencing><Staining method><Stains><Synapses><Synaptic><TLR4><TLR4 gene><TREM2><TREM2 gene><Tauopathies><Testing><Toll Homologue><Transgenic Mice><Transgenic Organisms><Triggering Receptor Expressed in Myeloid Cells 2><Triggering Receptor Expressed on Myeloid Cells 2><Variant><Variation><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age related neurodegeneration><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><ages><aging associated neurodegeneration><aging associated neurodegenerative disease><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><alzheimer model><alzheimer risk><amebocyte><amyloid beta plaque><amyloid-b plaque><analyzing longitudinal><apo E-3><apo E-4><apo E3><apo E4><apo epsilon4><apoE epsilon 4><apoE-3><apoE-4><apoE3><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-3><apolipoprotein E-4><apolipoprotein E3><apolipoprotein E4><astrocytic glia><aβ plaques><brain tissue><cell type><cholest-5-ene-3 beta,25-diol><cholesterol biosynthesis><cholesterol metabolism><cored plaque><cytokine><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diffuse plaque><early onset><fat metabolism><genetic risk factor><gitter cell><hippocampal><inherited factor><inhibitor><late onset alzheimer><lateral ventricle><lipid metabolism><lipidomics><longitudinal analysis><male><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><mouse model><murine model><nerve cell death><nerve cell loss><nerve cement><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurodegenerative illness><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuroinflammation><neuroinflammatory><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuron toxicity><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuronal survival><neuronal toxicity><neuropathologic><neuropathologic tau><neuropathological><neuropathological tau><neuropathology><neurotoxicity><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><osmotic minipump><overexpress><overexpression><pathophysiology><pathway><perivascular glial cell><piriform cortex><prevent><preventing><primary degenerative dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><sNuc-Seq><senile dementia of the Alzheimer type><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><sterol-regulatory element-binding protein 2><synapse><tangle><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><toll-like receptor 4><transgenic><τ Proteins><♀><♂>

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Chunyu Liu

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$444,065

FY 2026

Project Title

Life's Essential 8, Digital Cognitive Markers, and Alzheimer's Disease Risk

Grant Number:

5R01AG086303-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Effective long-term drug treatments for Alzheimer’s disease (AD) remain elusive. Reducing major modifiable lifestyle and clinical risk factors, quantified by Life’s Essential 8 (LE8), may delay symptom onset or progression. The success of lifestyle intervention trials relies on the e...

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Wilma A. Bainbridge

UNIVERSITY OF CHICAGO, CHICAGO, IL

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$410,000

FY 2026

Project Title

The neural and behavioral causes underlying differences between visual perception and memory

Grant Number:

5R01EY034432-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Until recently, it was thought that our memories occur as a reactivation of perception – reconjuring the same visual information and neural patterns (dubbed the sensory reinstatement hypothesis; e.g., Buckner & Wheeler, 2001). However, in recent work, we observed surprising differenc...

Research Terms

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AMANDA G PAULOVICH

FRED HUTCHINSON CANCER CENTER, SEATTLE, WA

Good lead · 66/100

Likely hiring

Solid budget

Recent

Active award

$405,509

FY 2026

Project Title

Optimizing pre-analytical variables for reliable mass spectrometry-based quantification of immunomodulatory proteins in cerebrospinal fluid in pediatric neuro-oncology trials

Grant Number:

5U01CA295226-02

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/19/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT The core aim of this study is to systematically investigate and mitigate the impact of preanalytical variables on the accuracy and reliability of targeted, multiple reaction monitoring mass spectrometry (MRM-MS)-based immune protein measurements in cerebrospinal fluid (CSF) ...

Research Terms

<0-11 years old><21+ years old><AD dementia><Address><Adoption><Adult><Adult Human><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Analytic Chemistry><Analytical Chemistry><Apoplexy><Assay><Bioassay><Biological Assay><Biological Markers><Blood><Blood Plasma><Blood Reticuloendothelial System><Body Tissues><Brain Cancer><Brain Neoplasia><Brain Neoplasms><Brain Trauma><Brain Tumors><Brain Vascular Accident><CAR T cell therapy><CAR T therapy><Cancer Patient><Cause of Death><Cerebral Stroke><Cerebrospinal Fluid><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Checkpoint inhibitor><Child><Child Youth><Childhood><Childhood Brain Neoplasm><Childhood Brain Tumor><Children (0-21)><Clinical><Clinical Chemistry><Clinical Laboratory Improvement Amendments><Clinical Trials><Collaborations><Collection><Communities><Data><Disease Progression><Disseminated Sclerosis><Ensure><Evidence based practice><Gehrig's Disease><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><Immune><Immune Cell Activation><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune Markers><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune checkpoint inhibitor><Immune mediated therapy><Immune response><Immunes><Immunochemical Immunologic><Immunologic><Immunologic Diseases><Immunologic Markers><Immunological><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunologically><Immunologically Directed Therapy><Immunologics><Immunology procedure><Immunomodulation><Immunotherapy><Inflammatory Myelopathy><Link><Lou Gehrig Disease><Malignant Tumor of the Brain><Malignant neoplasm of brain><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measurement><Measures><Monitor><Multiple Sclerosis><Myelitis><Oncology><Oncology Cancer><Outcome><Paralysis Agitans><Parkinson><Parkinson Disease><Pathogenesis><Pathology><Patient Participation><Patients><Peer Review><Performance><Pharmacodynamics><Plasma><Plasma Serum><Predictive Value><Primary Parkinsonism><Primary Senile Degenerative Dementia><Process><Productivity><Prognosis><Proteins><Protocol><Protocols documentation><Publications><Quality Control><Reaction Time><Recommendation><Recovery><Reliability of Results><Research><Response RT><Response Time><Reticuloendothelial System, Serum, Plasma><Safety><Sampling><Scientific Publication><Source><Spinal Cord Inflammation><Standardization><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Stroke><Techniques><Testing><Time><Tissues><Traumatic Brain Injury><Tumor Tissue><Validation><Variant><Variation><Work><adulthood><bio-markers><biologic marker><biomarker><brain attack><cerebral spinal fluid><cerebral vascular accident><cerebrovascular accident><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor T cell therapy><chimeric antigen receptor T therapy><clinical relevance><clinically relevant><conference><convention><cytokine><evidence base><experiment><experimental research><experimental study><experiments><host response><immune activation><immune check point inhibitor><immune modulation><immune regulation><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based biomarkers><immune-based therapies><immune-based treatments><immuno therapy><immunologic assay><immunologic assay/test><immunologic reactivity control><immunological biomarkers><immunological markers><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><improved><improved outcome><insight><insular sclerosis><kids><multidisciplinary><multiple reaction monitoring><neural inflammation><neuro-oncology><neuroinflammation><neuroinflammatory><neurooncology><participant enrollment><patient enrollment><patient variability><patient variation><pediatric><pediatric brain neoplasm><pediatric brain tumor><primary degenerative dementia><prospective><protein biomarkers><protein markers><psychomotor reaction time><response><response biomarker><response markers><response to therapy><response to treatment><sample collection><senile dementia of the Alzheimer type><specimen collection><spinal fluid><statistical analysis><statistics><stroked><strokes><success><summit><symposia><symposium><therapeutic response><therapy response><tool><translational oncology><traumatic brain damage><treatment response><treatment responsiveness><tumors in the brain><validations><variability between patients><variation between patients><youngster>

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Soyeon Park

UNIVERSITY OF COLORADO, Boulder, CO

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$391,250

FY 2026

Project Title

Mechanisms of Chaperone-Mediated Control in the Assembly of the Proteasome

Grant Number:

5R35GM153336-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary In the current paradigm of protein degradation by the ubiquitin-proteasome system, ubiquitination of protein substrates has been considered as a major regulatory step. Hundreds of ubiquitinating enzymes regulate polyubiquitination, to target proteins to the proteasome for degradation...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><AD dementia><APF-1><ATP-Dependent Proteolysis Factor 1><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Binding><Biochemical><Biological><Cancers><Cell Body><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chaperone><Complex><Cytoplasm><Cytoplasmic Granules><Dedications><E3 Ligase><E3 Ubiquitin Ligase><Ensure><Enzyme Gene><Enzymes><Gankyrin><Goals><HMG-20><High Mobility Protein 20><Human><Knowledge><Macropain><Macroxyproteinase><Malignant Neoplasms><Malignant Tumor><Mediating><Metabolic Protein Degradation><Modeling><Modern Man><Molecular Chaperones><Molecular Interaction><Molecular Machines><Monitor><Multicatalytic Proteinase><NLS Peptide><Nerve Degeneration><Neuron Degeneration><Nuclear Localization Signal><Nuclear Localization Signal Peptide><Nucleus><Nutritional><Oncogene Products><Oncogene Proteins><Oncoproteins><PSMD10><PSMD10 gene><Paralysis Agitans><Parkinson><Parkinson Disease><Pathology><Polyubiquitin><Polyubiquitination><Primary Parkinsonism><Primary Senile Degenerative Dementia><Process><Prosome><Proteasome><Proteasome 26S Subunit Non-ATPase 10><Proteasome Endopeptidase Complex><Protein Turnover><Proteins><Proteomics><Proteosome><Public Health><Quality Control><Regulatory Protein Degradation><Research><Role><Series><Stress><Subcellular Process><Syndrome><System><Ubiquitilation><Ubiquitin><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><Yeast Model System><biologic><combat><granule><human disease><in vivo><malignancy><multicatalytic endopeptidase complex><neoplasm/cancer><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><nutritious><poly-ubiquitin><preservation><prevent><preventing><primary degenerative dementia><protein degradation><senile dementia of the Alzheimer type><social role><therapeutic target><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase><yeast model>

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Eillen Tecle

MEDICAL COLLEGE OF WISCONSIN, MILWAUKEE, WI

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$390,000

FY 2026

Project Title

Metabolic Regulation of Immunity in C. elegans

Grant Number:

1R35GM161455-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Dysregulation of fundamental signaling pathways due to perturbations of cellular metabolites can have devastating consequences for human health. For example, inborn errors of purine metabolism cause alterations in levels of purine nucleotides and their metabolites, resulting in a var...

Research Terms

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Paul Nils Valdmanis

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$388,750

FY 2026

Project Title

Novel approaches to identify tandem repeat expansions in neurodegenerative disease

Grant Number:

5R01NS122766-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Alzheimer’s disease (AD) is one of the most common neurodegenerative diseases and has a high global health burden. While several AD genetic risk loci have been identified, the causal variant at these genome- wide association study (GWAS) sites is still unknown despite intensive sequencing efforts. I...

Research Terms

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Steven W Barger

UNIV OF ARKANSAS FOR MED SCIS, LITTLE ROCK, AR

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$382,500

FY 2026

Project Title

Role of glucose transport in Alzheimer's disease pathogenesis

Grant Number:

5R01AG084473-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Alzheimer’s disease (AD) is associated with a decline in the brain’s use of glucose, its most important fuel. Astrocytes play a key role in shuttling glucose from the bloodstream to where it is needed by the neuronal units of activity deeper in the brain tissue. We find evidence of a defect in a key...

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Joan B Broderick

MONTANA STATE UNIVERSITY - BOZEMAN, BOZEMAN, MT

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$380,336

FY 2026

Project Title

Radical SAM Enzymes: Radical Mechanisms Central to Biology

Grant Number:

5R35GM131889-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2019

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary / Abstract Radical SAM is the largest enzyme superfamily known, with its members catalyzing a remarkable diversity of reactions in all domains of life. Radical SAM enzymes are involved in the synthesis of essential cofactors and antibiotics, repair of DNA damage, and the assembly of complex ...

Research Terms

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Esther Marian Blessing

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$377,253

FY 2026

Project Title

Sleep and Temperature Disturbance as risk factors for Alzheimer's Disease in Down Syndrome: a Longitudinal Study

Grant Number:

3R01AG080769-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Abstract Down syndrome (DS), the most frequent form of intellectual disability of genetic origin, involves a >95% cumulative risk of Alzheimer’s Disease (AD) by the seventh decade. Further, AD is now the most common cause of death in this population as life expectancy in DS individua...

Research Terms

<21+ years old><A β-42><A β42><A-beta 42><A-beta42><AD biological marker><AD biomarker><AD dementia><AD pathology><AD related biomarker><AD risk><AD risk factor><APOE e4><APOE-ε4><APOEε4><Abeta-42><Abeta42><Acceleration><Active Follow-up><Adult><Adult Human><Affect><Age><Age of Onset><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's pathology><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><Ammon Horn><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-42><Amyloid beta-Protein><Amyloid beta42><Amyloid β><Amyloid β-42><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β42><Amyloidβ-42><Amyloidβ42><Apnea><Aβ><Aβ-42><Aβ42><Biological Markers><Blood><Blood Plasma><Blood Reticuloendothelial System><Body Temperature><Body Temperature Regulation><Body Thermoregulation><Brain><Brain Nervous System><Brain region><Cause of Death><Cerebrospinal Fluid><Circadian Dysregulation><Circadian Rhythms><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Cornu Ammonis><Data><Data Collection><Delta Wave><Delta Wave sleep><Disease Marker><Disease Progression><Disturbance in cognition><Down Syndrome><Dysfunction><EOAD><Early Onset Alzheimer Disease><Encephalon><Evaluation><Functional disorder><Genetic><Genetic Diseases><Goals><Heterogeneity><High Prevalence><Hippocampus><Home><Hour><Impaired cognition><Individual><Individuals with down syndrome><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Langdon Down syndrome><Lead><Life Expectancy><Light><Literature><Longitudinal Studies><Longitudinal Surveys><Longitudinal observational study><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Measurement><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Modeling><Mongolism><NMR Imaging><NMR Tomography><Nerve Degeneration><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Nyctohemeral Rhythm><Obstructive Sleep Apnea><Onset of illness><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Pathology><Pb element><Persons><Photoradiation><Physiologic Thermoregulation><Physiopathology><Plasma><Plasma Serum><Polysomnography><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Rad.-PET><Research><Reticuloendothelial System, Serum, Plasma><Risk Factors><Severities><Sleep><Sleep Monitoring><Sleep disturbances><Slow-Wave Sleep><Somnography><Structure><Study models><Syndrome, Sleep Apnea, Obstructive><Tauopathies><Telemetries><Telemetry><Temperature><Testing><Thermoregulation><Thick><Thickness><Trisomy 21><Twenty-Four Hour Rhythm><Work><Wrist><Zeugmatography><a beta peptide><aberrant sleep><abeta><actigraph><actigraphy><active followup><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged><ages><alzheimer risk><amyloid beta><amyloid-b protein><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><autosomal dominant AD><autosomal dominant Alzheimer's disease><beta amyloid fibril><bio-markers><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><cerebral spinal fluid><chromosome 21 trisomy><chromosome 21 trisomy syndrome><circadian><circadian abnormality><circadian disruption><circadian disturbance><circadian dysfunction><circadian impairment><circadian process><circadian rhythmicity><cognitive assessment><cognitive change><cognitive dysfunction><cognitive loss><cognitive performance><cognitive testing><cohort><congenital acromicria syndrome><cumulative risk><daily biorhythm><disease onset><disorder onset><disrupted sleep><disturbed sleep><down syndrome individuals><down syndrome patients><early onset AD><early onset Alzheimer's><follow up><follow-up><followed up><followup><genetic condition><genetic disorder><heavy metal Pb><heavy metal lead><high risk><hippocampal><homes><impaired sleep><indexing><intellectual and developmental disability><irregular sleep><later in life><later life><life-time risk><lifetime risk><limited intellectual functioning><long term observational study><long-term study><longitudinal outcome studies><longitudinal research study><malleable risk><microtubule bound tau><microtubule-bound tau><modifiable risk><morbus Down><neural degeneration><neural imaging><neuro-imaging><neurodegeneration><neurodegenerative><neurofilament><neuroimaging><neurological degeneration><neurological imaging><neuronal degeneration><neuropathologic tau><neuropathological tau><novel><older adult><older adulthood><p-tau><p-τ><pathophysiology><patients with down syndrome><people with down syndrome><phospho-tau><phospho-τ><phosphorylated tau><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><post-translational modification of tau><posttranslational modification of tau><pre-clinical><preclinical><primary degenerative dementia><progression biomarker><progression marker><pseudohypertrophic progressive muscular dystrophy><rate of change><recruit><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><screening><screenings><senile dementia of the Alzheimer type><sex><sleep amount><sleep disruption><sleep duration><sleep dysregulation><sleep episode><sleep interval><sleep length><sleep measurement><sleep period><sleep polysomnography><sleep quantity><sleep time><sleep/wake disruption><sleep/wake disturbance><soluble amyloid precursor protein><spinal fluid><symptomatology><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau phosphorylation><tau posttranslational modification><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><telemetric><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><trisomy 21 syndrome><uptake><τ Proteins><τ phosphorylation>

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Juan Fortea

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$377,253

FY 2026

Project Title

Sleep and Temperature Disturbance as risk factors for Alzheimer's Disease in Down Syndrome: a Longitudinal Study

Grant Number:

3R01AG080769-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Abstract Down syndrome (DS), the most frequent form of intellectual disability of genetic origin, involves a >95% cumulative risk of Alzheimer’s Disease (AD) by the seventh decade. Further, AD is now the most common cause of death in this population as life expectancy in DS individua...

Research Terms

<21+ years old><A β-42><A β42><A-beta 42><A-beta42><AD biological marker><AD biomarker><AD dementia><AD pathology><AD related biomarker><AD risk><AD risk factor><APOE e4><APOE-ε4><APOEε4><Abeta-42><Abeta42><Acceleration><Active Follow-up><Adult><Adult Human><Affect><Age><Age of Onset><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's pathology><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><Ammon Horn><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-42><Amyloid beta-Protein><Amyloid beta42><Amyloid β><Amyloid β-42><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β42><Amyloidβ-42><Amyloidβ42><Apnea><Aβ><Aβ-42><Aβ42><Biological Markers><Blood><Blood Plasma><Blood Reticuloendothelial System><Body Temperature><Body Temperature Regulation><Body Thermoregulation><Brain><Brain Nervous System><Brain region><Cause of Death><Cerebrospinal Fluid><Circadian Dysregulation><Circadian Rhythms><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Cornu Ammonis><Data><Data Collection><Delta Wave><Delta Wave sleep><Disease Marker><Disease Progression><Disturbance in cognition><Down Syndrome><Dysfunction><EOAD><Early Onset Alzheimer Disease><Encephalon><Evaluation><Functional disorder><Genetic><Genetic Diseases><Goals><Heterogeneity><High Prevalence><Hippocampus><Home><Hour><Impaired cognition><Individual><Individuals with down syndrome><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Langdon Down syndrome><Lead><Life Expectancy><Light><Literature><Longitudinal Studies><Longitudinal Surveys><Longitudinal observational study><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Measurement><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Modeling><Mongolism><NMR Imaging><NMR Tomography><Nerve Degeneration><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Nyctohemeral Rhythm><Obstructive Sleep Apnea><Onset of illness><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Pathology><Pb element><Persons><Photoradiation><Physiologic Thermoregulation><Physiopathology><Plasma><Plasma Serum><Polysomnography><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Rad.-PET><Research><Reticuloendothelial System, Serum, Plasma><Risk Factors><Severities><Sleep><Sleep Monitoring><Sleep disturbances><Slow-Wave Sleep><Somnography><Structure><Study models><Syndrome, Sleep Apnea, Obstructive><Tauopathies><Telemetries><Telemetry><Temperature><Testing><Thermoregulation><Thick><Thickness><Trisomy 21><Twenty-Four Hour Rhythm><Work><Wrist><Zeugmatography><a beta peptide><aberrant sleep><abeta><actigraph><actigraphy><active followup><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged><ages><alzheimer risk><amyloid beta><amyloid-b protein><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><autosomal dominant AD><autosomal dominant Alzheimer's disease><beta amyloid fibril><bio-markers><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><cerebral spinal fluid><chromosome 21 trisomy><chromosome 21 trisomy syndrome><circadian><circadian abnormality><circadian disruption><circadian disturbance><circadian dysfunction><circadian impairment><circadian process><circadian rhythmicity><cognitive assessment><cognitive change><cognitive dysfunction><cognitive loss><cognitive performance><cognitive testing><cohort><congenital acromicria syndrome><cumulative risk><daily biorhythm><disease onset><disorder onset><disrupted sleep><disturbed sleep><down syndrome individuals><down syndrome patients><early onset AD><early onset Alzheimer's><follow up><follow-up><followed up><followup><genetic condition><genetic disorder><heavy metal Pb><heavy metal lead><high risk><hippocampal><homes><impaired sleep><indexing><intellectual and developmental disability><irregular sleep><later in life><later life><life-time risk><lifetime risk><limited intellectual functioning><long term observational study><long-term study><longitudinal outcome studies><longitudinal research study><malleable risk><microtubule bound tau><microtubule-bound tau><modifiable risk><morbus Down><neural degeneration><neural imaging><neuro-imaging><neurodegeneration><neurodegenerative><neurofilament><neuroimaging><neurological degeneration><neurological imaging><neuronal degeneration><neuropathologic tau><neuropathological tau><novel><older adult><older adulthood><p-tau><p-τ><pathophysiology><patients with down syndrome><people with down syndrome><phospho-tau><phospho-τ><phosphorylated tau><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><post-translational modification of tau><posttranslational modification of tau><pre-clinical><preclinical><primary degenerative dementia><progression biomarker><progression marker><pseudohypertrophic progressive muscular dystrophy><rate of change><recruit><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><screening><screenings><senile dementia of the Alzheimer type><sex><sleep amount><sleep disruption><sleep duration><sleep dysregulation><sleep episode><sleep interval><sleep length><sleep measurement><sleep period><sleep polysomnography><sleep quantity><sleep time><sleep/wake disruption><sleep/wake disturbance><soluble amyloid precursor protein><spinal fluid><symptomatology><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau phosphorylation><tau posttranslational modification><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><telemetric><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><trisomy 21 syndrome><uptake><τ Proteins><τ phosphorylation>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Joseph M Santin

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$376,339

FY 2026

Project Title

Homeostatic plasticity mechanisms regulate behavior in vivo

Grant Number:

5R01NS114514-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2021

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract A remarkable trait of the healthy brain is that it can generate stable behaviors that last for decades. When this fails to occur, a range of neurological disorders follow. An emerging view is that neurons can sense disturbances in their activity and then make compensatory adjustments to sta...

Research Terms

<21+ years old><AD dementia><Adaptive Behaviors><Address><Adult><Adult Human><Air><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Animals><Behavior><Bioinformatics><Biologic Models><Biological Models><Brain><Brain Nervous System><Brain Stem><Brainstem><Breathing><Cell Body><Cells><Compensation><Data><Disease><Disorder><Electromyography><Electrophysiology><Electrophysiology (science)><Encephalon><Ensure><Environment><Epilepsy><Epileptic Seizures><Epileptics><Exhibits><Failure><Frog><Funding Opportunities><Gene Expression><Goals><Hydrogen Oxide><Ice Cover><Ice Sheet><Individual><Intrinsic drive><K channel><Life><Link><Lung><Lung Respiratory System><Measures><Memory><Model System><Modeling><Modernization><Molecular><Motor><Motor Cell><Motor Neurons><Nature><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurobiology><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Neurophysiology - biologic function><Neurophysiology / Electrophysiology><Neurosciences><Output><Performance><Physiologic><Physiological><Physiology><Population><Potassium Channel><Potassium Ion Channels><Prevalence><Primary Senile Degenerative Dementia><Process><Pump><Rana><Regulation><Research><Respiratory Aspiration><Respiratory Inspiration><Seizure Disorder><Shapes><Stimulus><Synapses><Synaptic><Synaptic plasticity><System><Temperature><Testing><Time><Walking><Water><Work><adaptation behavior><adaptive behavior><adulthood><candidate identification><cold temperature><electrophysiological><epilepsia><epileptogenic><extracellular><gene regulatory network><ice floe><improved><in vivo><innovate><innovation><innovative><insight><inspiration><life span><lifespan><low temperature><motoneuron><motor behavior><neural><neural function><neurobiological><neurological disease><neuromuscular function><neuron component><neuronal><patch clamp><primary degenerative dementia><programs><respiratory><response><santin><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><synapse><trait><ventilation>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ching-On Wong

RUTGERS THE STATE UNIV OF NJ NEWARK, NEWARK, NJ

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$343,438

FY 2026

Project Title

Role of TTYH1 in mobilizing lipids and ApoE in glia: Implications for brain aging and neurodegeneration

Grant Number:

5R01AG081379-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Lipids occupy over half of the dry weight of human brain. Brain cells rely on lipid metabolism to meet energy needs, perform signaling functions, and regulate membrane integrity and dynamics. Alterations in lipidomic profiles have been observed in aging brains and in neurodegenerativ...

Research Terms

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RONALD G CRYSTAL

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Good lead · 62/100

Large award

Very recent

Active award

Team-scale grant

$3,252,734

FY 2026

Project Title

Gene Therapy for APOE4 Homozygous Alzheimer's Disease

Grant Number:

1UG3AG098024-01

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract. Variants of APOE are the major genetic risk factors for Alzheimer’s disease (AD). APOE has 3 common variants; APOE3 average risk, APOE4 high risk and APOE2 protective. This data, and in E2E4 heterozygotes, E2 cancels out deleterious effects of E4, led to the concept that gene therapy of a ...

Research Terms

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Rachel Frances Buckley

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$993,000

FY 2026

Project Title

The inactive X: discovering sex genes that influence female vulnerability to Alzheimer's disease

Grant Number:

4DP2AG082342-02

Activity Code:

DP2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Of the two hallmark proteinopathies, b-amyloid and tau, that define Alzheimer’s disease (AD), studies consistently show that women exhibit higher levels of tau than men. This finding is well-characterized in older women, even those who are considered clinically normal, but the biolog...

Research Terms

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YADONG HUANG

J. DAVID GLADSTONE INSTITUTES, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$941,364

FY 2026

Project Title

Study Alzheimer's Disease Protective APOE Variants

Grant Number:

5R01AG085468-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The complexity and multifactorial nature of Alzheimer’s disease (AD) pose unique challenges for mechanistic studies and developing therapies. Emerging evidence strongly suggests that AD is a consequence of age- dependent neural network dysfunction in brain regions that mostly affect ...

Research Terms

<3-D><3-Dimensional><3D><AD dementia><AD model><AD pathology><AD risk><AD risk factor><APOE><APOE e3><APOE e4><APOE-ε4><APOEε4><Affect><Age><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's pathology><Alzheimers Dementia><Ammon Horn><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Apo-E><ApoE protein><Apolipoprotein E><Aβ><Behavioral><Brain region><Cell Culture Techniques><Cognition><Cornu Ammonis><DNA mutation><Dose><EOAD><Early Onset Alzheimer Disease><FTD dementia><Frontal Temporal Dementia><Frontotemporal Dementia><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetic predisposing factor><Goals><Hippocampus><Human><Isoforms><Knock-in><Late Onset Alzheimer Disease><Late onset AD><MT-bound tau><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Mutation><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neuritic Plaques><Neurocyte><Neurofibrillary Tangles><Neurons><Onset of illness><PSEN1><Pathogenesis><Pathogenicity Factors><Pathologic><Pathology><Performance><Primary Senile Degenerative Dementia><Protein Isoforms><Role><S182 protein><Senile Plaques><Single-Nucleus Sequencing><Variant><Variation><Virulence Factors><a beta peptide><aberrant tau><aberrant tau protein><abeta><abeta accumulation><abeta aggregation><abnormal tau><abnormal tau protein><age associated><age correlated><age dependent><age linked><age related><age specific><ages><alzheimer model><alzheimer risk><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid beta plaque><amyloid β accumulation><amyloid β aggregation><amyloid-b plaque><amyloid-b protein><apo E-3><apo E-4><apo E3><apo E4><apo epsilon4><apoE epsilon 4><apoE-3><apoE-4><apoE3><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-3><apolipoprotein E-4><apolipoprotein E3><apolipoprotein E4><aβ accumulation><aβ aggregation><aβ plaques><beta amyloid fibril><cell culture><cell cultures><cored plaque><develop therapy><diffuse plaque><disease onset><disorder onset><early onset><early onset AD><early onset Alzheimer's><extracellular><front temporal dementia><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><genetic risk factor><genome mutation><hippocampal><hyper-phosphorylated tau><hyperphosphorylated tau><inherited factor><insight><intervention development><knockin><late onset alzheimer><low-frequency mutation><microtubule associated protein tau mutation><microtubule bound tau><microtubule-associated protein tau mutation><microtubule-bound tau><mouse model><murine model><mutant><mutant tau><mutant tau protein><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><network dysfunction><neural network><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuronal><novel><pathogenic tau><pathogenic tau gene mutation><pathogenic tau protein><pathological change in tau><pathological tau><pathological tau protein><presenilin 1 protein><presenilin-1><prevent><preventing><primary degenerative dementia><protective effect><rare allele><rare mutation><rare variant><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><sNuc-Seq><senile dementia of the Alzheimer type><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><soluble amyloid precursor protein><tangle><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau abnormality><tau factor><tau intronic mutation><tau mutation><tau pathological change><therapeutic agent development><therapeutic development><therapy development><three dimensional><transcriptomics><treatment development><τ Proteins><τ mutation>

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Misha Yuri Zilberter

J. DAVID GLADSTONE INSTITUTES, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$941,364

FY 2026

Project Title

Study Alzheimer's Disease Protective APOE Variants

Grant Number:

5R01AG085468-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The complexity and multifactorial nature of Alzheimer’s disease (AD) pose unique challenges for mechanistic studies and developing therapies. Emerging evidence strongly suggests that AD is a consequence of age- dependent neural network dysfunction in brain regions that mostly affect ...

Research Terms

<3-D><3-Dimensional><3D><AD dementia><AD model><AD pathology><AD risk><AD risk factor><APOE><APOE e3><APOE e4><APOE-ε4><APOEε4><Affect><Age><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's pathology><Alzheimers Dementia><Ammon Horn><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Apo-E><ApoE protein><Apolipoprotein E><Aβ><Behavioral><Brain region><Cell Culture Techniques><Cognition><Cornu Ammonis><DNA mutation><Dose><EOAD><Early Onset Alzheimer Disease><FTD dementia><Frontal Temporal Dementia><Frontotemporal Dementia><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetic predisposing factor><Goals><Hippocampus><Human><Isoforms><Knock-in><Late Onset Alzheimer Disease><Late onset AD><MT-bound tau><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Mutation><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neuritic Plaques><Neurocyte><Neurofibrillary Tangles><Neurons><Onset of illness><PSEN1><Pathogenesis><Pathogenicity Factors><Pathologic><Pathology><Performance><Primary Senile Degenerative Dementia><Protein Isoforms><Role><S182 protein><Senile Plaques><Single-Nucleus Sequencing><Variant><Variation><Virulence Factors><a beta peptide><aberrant tau><aberrant tau protein><abeta><abeta accumulation><abeta aggregation><abnormal tau><abnormal tau protein><age associated><age correlated><age dependent><age linked><age related><age specific><ages><alzheimer model><alzheimer risk><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid beta plaque><amyloid β accumulation><amyloid β aggregation><amyloid-b plaque><amyloid-b protein><apo E-3><apo E-4><apo E3><apo E4><apo epsilon4><apoE epsilon 4><apoE-3><apoE-4><apoE3><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-3><apolipoprotein E-4><apolipoprotein E3><apolipoprotein E4><aβ accumulation><aβ aggregation><aβ plaques><beta amyloid fibril><cell culture><cell cultures><cored plaque><develop therapy><diffuse plaque><disease onset><disorder onset><early onset><early onset AD><early onset Alzheimer's><extracellular><front temporal dementia><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><genetic risk factor><genome mutation><hippocampal><hyper-phosphorylated tau><hyperphosphorylated tau><inherited factor><insight><intervention development><knockin><late onset alzheimer><low-frequency mutation><microtubule associated protein tau mutation><microtubule bound tau><microtubule-associated protein tau mutation><microtubule-bound tau><mouse model><murine model><mutant><mutant tau><mutant tau protein><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><network dysfunction><neural network><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuronal><novel><pathogenic tau><pathogenic tau gene mutation><pathogenic tau protein><pathological change in tau><pathological tau><pathological tau protein><presenilin 1 protein><presenilin-1><prevent><preventing><primary degenerative dementia><protective effect><rare allele><rare mutation><rare variant><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><sNuc-Seq><senile dementia of the Alzheimer type><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><soluble amyloid precursor protein><tangle><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau abnormality><tau factor><tau intronic mutation><tau mutation><tau pathological change><therapeutic agent development><therapeutic development><therapy development><three dimensional><transcriptomics><treatment development><τ Proteins><τ mutation>

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Chongzhao Ran

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$826,732

FY 2026

Project Title

Development of sensitive PET tracers of pan-Amyloid-beta species for Alzheimer's disease

Grant Number:

5R01AG085562-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The recent FDA approval of Leqembi (Lecanemab) for Alzheimer’s disease (AD) has spurred great optimism, and this approval also likely opens a door for preventive treatment for AD. However, currently available PET tracers have limited capacity for this preventive purpose. More sensitive new PET trace...

Research Terms

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Rhoda Au

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$817,044

FY 2026

Project Title

Cognitive heterogeneity in those with high Alzheimer's Disease Risk

Grant Number:

5R01AG062109-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2018

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The insidious nature of Alzheimer’s disease (AD) spans decades and adds complexity to detect the disease earlier in its course. A significant consideration is that those identified as at risk for AD may not necessarily develop clinically expressed disease. Traditional methods for det...

Research Terms

<3-D><3-Dimensional><3D><AD biological marker><AD biomarker><AD dementia><AD pathology><AD related biomarker><AD risk><AD risk factor><AD therapy><AD treatment><APOE><Adoption><Affect><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's diagnosis><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease diagnosis><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's related biomarker><Alzheimer's therapy><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Apo-E><ApoE protein><Apolipoprotein E><Autopsy><Aβ><Back><Behavioral><Biological Markers><Blood Plasma><Body Tissues><Cardiovascular Diseases><Causality><Cell Communication and Signaling><Cell Signaling><Characteristics><Classification><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Communities><Data><Data Analytics><Data Bases><Databases><Dementia><Disease><Disease Progression><Disorder><Disturbance in cognition><Dorsum><Early Intervention><Etiology><Female><Framingham Heart Study><Genetic><Goals><Grain><Heterogeneity><Impaired cognition><Individual><Intervention><Intracellular Communication and Signaling><Learning><Link><Literature><MR Imaging><MR Tomography><MRI><MRI Scans><MRIs><MT-bound tau><Magnetic Resonance Imaging><Magnetic Resonance Imaging Scan><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Modeling><NIAAA><NMR Imaging><NMR Tomography><National Institute on Alcohol Abuse and Alcoholism><Nature><Nerve Degeneration><Neuron Degeneration><Neuropsychologic Tests><Neuropsychological Tests><Neuropsychologies><Neuropsychology><Nuclear Magnetic Resonance Imaging><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Participant><Persons><Plasma><Plasma Serum><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Rad.-PET><Reporting><Research Resources><Resources><Reticuloendothelial System, Serum, Plasma><Risk><Risk Assessment><Risk Factors><Signal Transduction><Signal Transduction Systems><Signaling><Standardization><Statistical Methods><Systematics><Tauopathies><Time><Tissues><Translating><Vascular Diseases><Vascular Disorder><Zeugmatography><a beta peptide><abeta><alzheimer risk><amyloid beta><amyloid-b protein><beta amyloid fibril><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><blood vessel disorder><brain MR imaging><brain MRI><brain magnetic resonance imaging><cardiovascular disorder><causation><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><clinical predictors><cognitive ability><cognitive change><cognitive dysfunction><cognitive loss><cognitive performance><cohort><data base><deep learning><deep learning method><deep learning strategy><detection method><detection procedure><detection technique><digital><digital measure><digital metric><disease causation><disease risk><disorder risk><effective therapy><effective treatment><high risk><high risk group><high risk individual><high risk people><high risk population><in vivo><indexing><microtubule bound tau><microtubule-bound tau><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><multi-modal data><multi-modal datasets><multi-modality><multimodal data><multimodal datasets><multimodality><necropsy><neural degeneration><neural imaging><neuro-imaging><neurodegeneration><neurodegenerative><neuroimaging><neurological degeneration><neurological imaging><neuronal degeneration><neuropathologic tau><neuropathological tau><neuropsychologic><novel><old age><performance tests><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><postmortem><pre-clinical><preclinical><primary degenerative dementia><prospective><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sex><soluble amyloid precursor protein><statistic methods><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><three dimensional><vascular dysfunction><vascular risk factor><vasculopathy><τ Proteins><♀>

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Vijaya B. Kolachalama

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$817,044

FY 2026

Project Title

Cognitive heterogeneity in those with high Alzheimer's Disease Risk

Grant Number:

5R01AG062109-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2018

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The insidious nature of Alzheimer’s disease (AD) spans decades and adds complexity to detect the disease earlier in its course. A significant consideration is that those identified as at risk for AD may not necessarily develop clinically expressed disease. Traditional methods for det...

Research Terms

<3-D><3-Dimensional><3D><AD biological marker><AD biomarker><AD dementia><AD pathology><AD related biomarker><AD risk><AD risk factor><AD therapy><AD treatment><APOE><Adoption><Affect><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's diagnosis><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease diagnosis><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's related biomarker><Alzheimer's therapy><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Apo-E><ApoE protein><Apolipoprotein E><Autopsy><Aβ><Back><Behavioral><Biological Markers><Blood Plasma><Body Tissues><Cardiovascular Diseases><Causality><Cell Communication and Signaling><Cell Signaling><Characteristics><Classification><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Communities><Data><Data Analytics><Data Bases><Databases><Dementia><Disease><Disease Progression><Disorder><Disturbance in cognition><Dorsum><Early Intervention><Etiology><Female><Framingham Heart Study><Genetic><Goals><Grain><Heterogeneity><Impaired cognition><Individual><Intervention><Intracellular Communication and Signaling><Learning><Link><Literature><MR Imaging><MR Tomography><MRI><MRI Scans><MRIs><MT-bound tau><Magnetic Resonance Imaging><Magnetic Resonance Imaging Scan><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Modeling><NIAAA><NMR Imaging><NMR Tomography><National Institute on Alcohol Abuse and Alcoholism><Nature><Nerve Degeneration><Neuron Degeneration><Neuropsychologic Tests><Neuropsychological Tests><Neuropsychologies><Neuropsychology><Nuclear Magnetic Resonance Imaging><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Participant><Persons><Plasma><Plasma Serum><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Rad.-PET><Reporting><Research Resources><Resources><Reticuloendothelial System, Serum, Plasma><Risk><Risk Assessment><Risk Factors><Signal Transduction><Signal Transduction Systems><Signaling><Standardization><Statistical Methods><Systematics><Tauopathies><Time><Tissues><Translating><Vascular Diseases><Vascular Disorder><Zeugmatography><a beta peptide><abeta><alzheimer risk><amyloid beta><amyloid-b protein><beta amyloid fibril><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><blood vessel disorder><brain MR imaging><brain MRI><brain magnetic resonance imaging><cardiovascular disorder><causation><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><clinical predictors><cognitive ability><cognitive change><cognitive dysfunction><cognitive loss><cognitive performance><cohort><data base><deep learning><deep learning method><deep learning strategy><detection method><detection procedure><detection technique><digital><digital measure><digital metric><disease causation><disease risk><disorder risk><effective therapy><effective treatment><high risk><high risk group><high risk individual><high risk people><high risk population><in vivo><indexing><microtubule bound tau><microtubule-bound tau><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><multi-modal data><multi-modal datasets><multi-modality><multimodal data><multimodal datasets><multimodality><necropsy><neural degeneration><neural imaging><neuro-imaging><neurodegeneration><neurodegenerative><neuroimaging><neurological degeneration><neurological imaging><neuronal degeneration><neuropathologic tau><neuropathological tau><neuropsychologic><novel><old age><performance tests><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><postmortem><pre-clinical><preclinical><primary degenerative dementia><prospective><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sex><soluble amyloid precursor protein><statistic methods><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><three dimensional><vascular dysfunction><vascular risk factor><vasculopathy><τ Proteins><♀>

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Lisa M Ellerby

BUCK INSTITUTE FOR RESEARCH ON AGING, NOVATO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$809,486

FY 2026

Project Title

Role of OXR1 and the retromer in brain aging and Alzheimer's disease and related dementias

Grant Number:

1R01AG095381-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Although some genetic risk factors for AD are known, the precise etiology of most cases of late-onset Alzheimer's disease (AD) is unknown. Unfortunately, AD therapies have been largely unsuccessful. Two important risk factors for AD, aging, and diet, remain poorly understood...

Research Terms

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Pankaj Kapahi

BUCK INSTITUTE FOR RESEARCH ON AGING, NOVATO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$809,486

FY 2026

Project Title

Role of OXR1 and the retromer in brain aging and Alzheimer's disease and related dementias

Grant Number:

1R01AG095381-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Although some genetic risk factors for AD are known, the precise etiology of most cases of late-onset Alzheimer's disease (AD) is unknown. Unfortunately, AD therapies have been largely unsuccessful. Two important risk factors for AD, aging, and diet, remain poorly understood...

Research Terms

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Erik Bradley Bloss

JACKSON LABORATORY, BAR HARBOR, ME

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$803,594

FY 2026

Project Title

Deconstruction of a Hypothalamic Exercise-responsive Circuit for Neuroprotection

Grant Number:

5R01AG079877-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Exercise slows the cognitive declines associated with aging and protects against the development and progression of neurodegenerative diseases such as Alzheimer's disease (AD). At the cellular level, exercise enhances synaptic connectivity and reduces markers of neuroinflammation in ...

Research Terms

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Liang Feng

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$797,780

FY 2026

Project Title

Molecular mechanisms of gamma-secretase modulation central to Alzheimer’s disease

Grant Number:

5R01AG080684-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Alzheimer’s disease (AD), a progressive neurodegenerative disease and leading cause of dementia, exacts a tremendous toll on both the healthcare system and society broadly. Although the pathogenesis of AD is poorly understood, it centers on the production of so-called β-amyloid (Aβ) peptides, which ...

Research Terms

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YUEMING LI

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$797,780

FY 2026

Project Title

Molecular mechanisms of gamma-secretase modulation central to Alzheimer’s disease

Grant Number:

5R01AG080684-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Alzheimer’s disease (AD), a progressive neurodegenerative disease and leading cause of dementia, exacts a tremendous toll on both the healthcare system and society broadly. Although the pathogenesis of AD is poorly understood, it centers on the production of so-called β-amyloid (Aβ) peptides, which ...

Research Terms

View Full Project Details on NIH Reporter

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MARCO COLONNA

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$775,250

FY 2026

Project Title

Spontaneous and Induced B cell and T cell responses in Alzheimer's Disease

Grant Number:

5R01AG081631-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Alzheimer disease (AD) is a neurodegenerative condition that causes progressive cognitive decline and death. The AD pathological hallmarks are extracellular amyloid β (Aβ) plaques and neurofibrillary tangles containing aggregated Tau protein. The US FDA recently approved aducanumab to promo...

Research Terms

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Edward S. Boyden

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$771,150

FY 2026

Project Title

Lipid imaging expansion microscopy to study Alzheimer's disease

Grant Number:

5R01AG087374-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Alzheimer's disease (AD) is a fatal neurodegenerative disease characterized by progressive cognitive decline and brain pathologies including amyloid-β (Aβ) peptide deposition, hyperphosphorylated tau accumulation, inflammation, and synaptic and neuronal loss. In addition to protein pathology, the ab...

Research Terms

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Li-Huei Tsai

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$771,150

FY 2026

Project Title

Lipid imaging expansion microscopy to study Alzheimer's disease

Grant Number:

5R01AG087374-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Alzheimer's disease (AD) is a fatal neurodegenerative disease characterized by progressive cognitive decline and brain pathologies including amyloid-β (Aβ) peptide deposition, hyperphosphorylated tau accumulation, inflammation, and synaptic and neuronal loss. In addition to protein pathology, the ab...

Research Terms

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Craig Lewis Duvall

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$761,386

FY 2026

Project Title

Targeting brain myeloid cells with siRNA-lipid conjugates for treatment of Alzheimer's disease

Grant Number:

5R01AG092015-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary Brain myeloid cells, including microglia and macrophages, selectively express several genes that confer risk for late-onset Alzheimer’s disease (AD)—for example CD33, which regulates amyloid beta clearance. As such, there is substantial interest in using oligonucleotide drugs—including siRNA...

Research Terms

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Ethan Lippmann

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$761,386

FY 2026

Project Title

Targeting brain myeloid cells with siRNA-lipid conjugates for treatment of Alzheimer's disease

Grant Number:

5R01AG092015-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary Brain myeloid cells, including microglia and macrophages, selectively express several genes that confer risk for late-onset Alzheimer’s disease (AD)—for example CD33, which regulates amyloid beta clearance. As such, there is substantial interest in using oligonucleotide drugs—including siRNA...

Research Terms

View Full Project Details on NIH Reporter

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Ze Wang

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$758,508

FY 2026

Project Title

Deep-Learning Enhanced ASL MRI For Early AD Assessment

Grant Number:

5R01AG081693-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary Alzheimer’s Disease (AD) is a fatal disease without a cure. Understanding its neuromechanisms is a top research priority as it may provide regional targets for early intervention or for monitoring disease progression. Cerebral blood flow (CBF) is a fundamental physiological parameter indicat...

Research Terms

<21+ years old><3-D><3-Dimensional><3D><AD dementia><AD detection><AD pathway><AD-associated pathways><AD-related pathways><AD-specific pathways><AI system><Address><Adopted><Adult><Adult Human><Affect><Algorithm Design><Algorithmic Design><Algorithmic Engineering><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease detection><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's detection><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Arteries><Artificial Intelligence><Basic Research><Basic Science><Brain><Brain Nervous System><Brain Vascular><Brain region><Cell Communication and Signaling><Cell Signaling><Cerebrovascular Circulation><Clinical><Clinical Research><Clinical Study><Code><Coding System><Cognitive Manifestations><Cognitive Symptoms><Communities><Compensation><Computer Reasoning><Conflict><Conflict (Psychology)><Data><Data Set><Degenerative Neurologic Disorders><Differential Diagnosis><Disease><Disease Progression><Disorder><Early Diagnosis><Early Intervention><Encephalon><Ensure><Episodic memory><Head><Image><Intracellular Communication and Signaling><Knowledge><Label><Learning><MR Imaging><MR Tomography><MRI><MRIs><Machine Intelligence><Machine Learning><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Memory><Methods><Modeling><Monitor><Motion><NMR Imaging><NMR Tomography><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic><Neurologic Degenerative Conditions><Neurological><Neurosciences><Noise><Nuclear Magnetic Resonance Imaging><Output><Patients><Pattern><Performance><Perfusion><Persons><Physiologic><Physiological><Primary Senile Degenerative Dementia><Process><Property><Protocol><Protocols documentation><Research><Research Priority><Residual><Residual state><Resolution><Risk><Scanning><Scheme><Signal Transduction><Signal Transduction Systems><Signaling><Spin Labels><Techniques><Testing><Therapeutic Intervention><Time><Training><Translational Research><Translational Science><Variant><Variation><Work><Zeugmatography><adulthood><algorithm engineering><algorithmic composition><analytical method><arterial spin labeling><arterial spin tagging><biological signal transduction><blood flow in brain><brain blood circulation><brain blood flow><cerebral blood flow><cerebral circulation><cerebral vascular><cerebro-vascular><cerebrocirculation><cerebrovascular><cerebrovascular blood flow><cost><data acquisition><data acquisitions><de-noising><deep learning><deep learning method><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><denoising><early detection><experience><high risk><hypoperfusion><imaging><improved><indexing><innovate><innovation><innovative><intervention therapy><learning activity><learning method><learning network><learning strategies><learning strategy><life span><lifespan><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><machine learning based method><machine learning based model><machine learning method><machine learning methodologies><machine learning model><mechanisms in AD><mechanisms in Alzheimer's disease><multi-modality><multimodality><neural mechanism><neuro-vascular><neurodegenerative illness><neuromechanism><neuropsychiatric><neuropsychiatry><neurovascular><novel><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><pre-clinical><preclinical><primary degenerative dementia><resolutions><senile dementia of the Alzheimer type><stability testing><success><super high resolution><superresolution><technique development><three dimensional><translation research><translational investigation><ultra high resolution>

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Jiang Bian

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$756,277

FY 2026

Project Title

Eligibility criteria design for Alzheimer's trials with real-world data and explainable AI

Grant Number:

5R01AG080991-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Clinical trials are often conducted under idealized and rigorously controlled conditions to ensure internal validity (maximizing potential treatment efficacy) while balancing patient safety (e.g., serious adverse events [SAEs]); but these conditions—often reflected in trials’ eligibility cr...

Research Terms

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Fei Wang

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$756,277

FY 2026

Project Title

Eligibility criteria design for Alzheimer's trials with real-world data and explainable AI

Grant Number:

5R01AG080991-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Clinical trials are often conducted under idealized and rigorously controlled conditions to ensure internal validity (maximizing potential treatment efficacy) while balancing patient safety (e.g., serious adverse events [SAEs]); but these conditions—often reflected in trials’ eligibility cr...

Research Terms

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Michael A. Johnson

UNIVERSITY OF KANSAS LAWRENCE, LAWRENCE, KS

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$727,492

FY 2026

Project Title

Analytical Tools for Light-Initiated Zn2+ Signaling in Neurodegenerative Disease

Grant Number:

5R01AG087372-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Overwhelming evidence has implicated oxidative stress and zinc dysregulation as mechanisms that underlie neurodegeneration, especially in Alzheimer’s disease (AD) and Parkinson’s disease (PD). In its free, ionic state, Zn2+ undergoes co-release with glutamate in selected brain region...

Research Terms

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Michelle L Bell

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$724,841

FY 2026

Project Title

Susceptibility and adverse health outcomes related to weather-sensitive events among older Medicare beneficiaries with Alzheimer and Dementia

Grant Number:

4R01AG080948-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The WHO listed air pollution as one of the top ten threats in 2019, and earlier research indicates links between weather exposures and brain health. Further, the burden of older persons with Alzheimer’s disease (AD) and related dementias (ADRD) is expected to double by 2060. Simultaneously, wildfire...

Research Terms

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Tarik Benmarhnia

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$724,841

FY 2026

Project Title

Susceptibility and adverse health outcomes related to weather-sensitive events among older Medicare beneficiaries with Alzheimer and Dementia

Grant Number:

4R01AG080948-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The WHO listed air pollution as one of the top ten threats in 2019, and earlier research indicates links between weather exposures and brain health. Further, the burden of older persons with Alzheimer’s disease (AD) and related dementias (ADRD) is expected to double by 2060. Simultaneously, wildfire...

Research Terms

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Thomas Michael Gill

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$724,841

FY 2026

Project Title

Susceptibility and adverse health outcomes related to weather-sensitive events among older Medicare beneficiaries with Alzheimer and Dementia

Grant Number:

4R01AG080948-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The WHO listed air pollution as one of the top ten threats in 2019, and earlier research indicates links between weather exposures and brain health. Further, the burden of older persons with Alzheimer’s disease (AD) and related dementias (ADRD) is expected to double by 2060. Simultaneously, wildfire...

Research Terms

View Full Project Details on NIH Reporter

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Frederick Bennett

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$723,765

FY 2026

Project Title

Amyloid Beta CAR Macrophages: a cell engineering strategy to clear pathogenic proteins

Grant Number:

5R01NS129737-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/21/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Phagocytosis by microglia, the brain's resident macrophages, is central to Alzheimer Disease (AD) risk and pathogenesis. Current β-amyloid (Aβ) clearing immunotherapies use monoclonal antibodies to indirectly elicit phagocytosis, in an attempt to reverse AD manifestations. This form of passive immun...

Research Terms

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Saar Gill

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$723,765

FY 2026

Project Title

Amyloid Beta CAR Macrophages: a cell engineering strategy to clear pathogenic proteins

Grant Number:

5R01NS129737-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/21/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Phagocytosis by microglia, the brain's resident macrophages, is central to Alzheimer Disease (AD) risk and pathogenesis. Current β-amyloid (Aβ) clearing immunotherapies use monoclonal antibodies to indirectly elicit phagocytosis, in an attempt to reverse AD manifestations. This form of passive immun...

Research Terms

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Ai Yamamoto

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$723,234

FY 2026

Project Title

Calcium signaling and autophagy defects in Alzheimer's disease neurons

Grant Number:

5R01AG090542-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT The broad, long-term objective of this grant application is to understand the mechanisms responsible for autophagy defects in neurons affected by Alzheimer’s disease (AD). Dysregulation of neuronal autophagy play important role in AD pathogenesis from the studies of both AD patients and ani...

Research Terms

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Erik Bradley Bloss

JACKSON LABORATORY, BAR HARBOR, ME

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$716,579

FY 2026

Project Title

Genetic dissection of microglia functions in complement-mediated synapse loss in Alzheimer s disease

Grant Number:

1R01AG096489-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2025

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Microglia are the macrophages of the brain and become activated in response to amyloid. Recently, single cell sequencing has defined multiple activated states of microglia including two states that are robustly induced in animals of Alzheimer’s disease (AD): disease associated microg...

Research Terms

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Gareth R Howell

JACKSON LABORATORY, BAR HARBOR, ME

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$716,579

FY 2026

Project Title

Genetic dissection of microglia functions in complement-mediated synapse loss in Alzheimer s disease

Grant Number:

1R01AG096489-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2025

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Microglia are the macrophages of the brain and become activated in response to amyloid. Recently, single cell sequencing has defined multiple activated states of microglia including two states that are robustly induced in animals of Alzheimer’s disease (AD): disease associated microg...

Research Terms

View Full Project Details on NIH Reporter

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Christopher G Burd

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$711,188

FY 2026

Project Title

Lipid Dynamics in the Golgi Apparatus

Grant Number:

5R35GM144096-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The organelle membrane system of the eukaryotic cell is constituted by two complementary lipid `territories'. One originates from the endoplasmic reticulum (ER), where lipid and protein synthesis occurs, and the other is encompasses the trans-Golgi network (TGN), plasma membrane, and organelles of e...

Research Terms

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Lyndsey Medora Anderson

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$705,901

FY 2026

Project Title

The RSELVES Study: Remote Sensing of (older adult partners') Engagement in Life and Variability in Everyday Support

Grant Number:

5R01AG080644-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Alzheimer’s disease is a leading cause of functional disability among older adults worldwide. Despite the inevitability of functional impairment in Alzheimer’s disease, large heterogeneity in the rate and order that specific functions are lost suggests that there are undiscovered way...

Research Terms

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Joel Summer Steele

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$705,901

FY 2026

Project Title

The RSELVES Study: Remote Sensing of (older adult partners') Engagement in Life and Variability in Everyday Support

Grant Number:

5R01AG080644-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Alzheimer’s disease is a leading cause of functional disability among older adults worldwide. Despite the inevitability of functional impairment in Alzheimer’s disease, large heterogeneity in the rate and order that specific functions are lost suggests that there are undiscovered way...

Research Terms

View Full Project Details on NIH Reporter

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QING WANG

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$704,981

FY 2026

Project Title

Quantitative Endogenous MRI Imaging of Neuroinflammation in AD

Grant Number:

5R01AG074909-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Neuroinflammation plays a central role in the pathogenesis of Alzheimer’s disease (AD) and links strongly with AD’s neuropathological hallmarks, including amyloid plaques and neurofibrillary tangles. While there have been tremendous strides over the last decade in the develo...

Research Terms

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Song Hu

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$683,028

FY 2026

Project Title

A fiber implant for long-term, deep-brain imaging and manipulation in mouse models of Alzheimer disease

Grant Number:

1R01AG095248-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Neurological disorders, such as Alzheimer disease (AD) and Parkinson disease, chronically affect critical regions of the deep brain, including the hippocampus and substantia nigra. Long-term monitoring of disease progression and responses to interventions in mouse models, which have ...

Research Terms

<2-photon><2-photon microscopy><AD dementia><AD model><Address><Affect><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimers Dementia><Ammon Horn><Amyloid><Amyloid Substance><Amyloidosis><Animal Model><Animal Models and Related Studies><Behavior><Behavioral><Biocompatible Materials><Biomaterials><Blood><Blood Reticuloendothelial System><Blood Tests><Blood Vessels><Blood flow><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain imaging><Brain region><Chronic><Cornu Ammonis><Development><Devices><Diameter><Disease Progression><Drug Delivery><Drug Delivery Systems><E-stim><Electric Stimulation><Encephalon><Encephalon Diseases><Evaluation><Face><Fiber><Functional Imaging><Goals><Hematologic Tests><Hematological Tests><Hematology Testing><Hippocampus><Histopathology><Hyperemia><Impairment><Implant><Inflammation><Intervention><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><J20><J20 mouse><Light><Link><Longitudinal Studies><Longitudinal Surveys><Memory><Memory Deficit><Memory Loss><Memory impairment><Methods><Mice><Mice Mammals><Microelectrodes><Microfluidics><Microscopy><Miniaturized Electrodes><Monitor><Murine><Mus><Nerve Degeneration><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Neuron Degeneration><O element><O2 element><Operative Procedures><Operative Surgical Procedures><Optics><Outcome><Oxygen><Paralysis Agitans><Parkinson><Parkinson Disease><Photoradiation><Physiologic Imaging><Primary Parkinsonism><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Public Health><Reporting><Resolution><Role><Secondary to><Specific qualifier value><Specified><Structure><Substantia Nigra><Substantia nigra structure><Surgical><Surgical Interventions><Surgical Procedure><Tauopathies><Techniques><Technology><Testing><Thallium><Therapeutic><Tissues><Tl element><Ultrasonic><Ultrasonics><Vascular Diseases><Vascular Disorder><Vasodilating Agent><Vasodilator Agents><Vasodilator Drugs><Vasodilators><Wild Type Mouse><Work><aged brain><ages><aging brain><alzheimer model><amyloid angiopathy><amyloid disease><amyloid pathology><aspirate><awake><biocompatibility><biological material><biomaterial compatibility><blood vessel disorder><brain visualization><design><designing><developmental><electrostimulation><endomicroscopy><endomicrosope><experiment><experimental research><experimental study><experiments><faces><facial><high resolution imaging><hippocampal><implantation><improved><indexing><innovate><innovation><innovative><insight><interest><lens><lenses><light microscopy><long-term study><longitudinal outcome studies><longitudinal research study><memory decline><memory dysfunction><microendoscope><microendoscopy><model of animal><molecular imaging><molecule imaging><mouse model><murine model><neural degeneration><neural stimulation><neurodegeneration><neurodegenerative><neurological degeneration><neurological disease><neuronal degeneration><neuropathologic tau><neuropathological tau><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><optical><optical fiber><pharmacologic><physiological imaging><prevent><preventing><primary degenerative dementia><resolutions><response><restoration><senile dementia of the Alzheimer type><site targeted delivery><social role><surgery><targeted delivery><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic target><timeline><tool><two photon excitation microscopy><two photon microscopy><two-photon><vascular><vascular amyloid><vascular amyloid accumulation><vascular amyloid build up><vascular amyloid deposition><vascular amyloid deposits><vascular amyloid pathology><vascular amyloidosis><vascular dysfunction><vasculopathy><wildtype mouse><µfluidic>

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Xiaoting Jia

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$683,028

FY 2026

Project Title

A fiber implant for long-term, deep-brain imaging and manipulation in mouse models of Alzheimer disease

Grant Number:

1R01AG095248-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Neurological disorders, such as Alzheimer disease (AD) and Parkinson disease, chronically affect critical regions of the deep brain, including the hippocampus and substantia nigra. Long-term monitoring of disease progression and responses to interventions in mouse models, which have ...

Research Terms

<2-photon><2-photon microscopy><AD dementia><AD model><Address><Affect><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimers Dementia><Ammon Horn><Amyloid><Amyloid Substance><Amyloidosis><Animal Model><Animal Models and Related Studies><Behavior><Behavioral><Biocompatible Materials><Biomaterials><Blood><Blood Reticuloendothelial System><Blood Tests><Blood Vessels><Blood flow><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain imaging><Brain region><Chronic><Cornu Ammonis><Development><Devices><Diameter><Disease Progression><Drug Delivery><Drug Delivery Systems><E-stim><Electric Stimulation><Encephalon><Encephalon Diseases><Evaluation><Face><Fiber><Functional Imaging><Goals><Hematologic Tests><Hematological Tests><Hematology Testing><Hippocampus><Histopathology><Hyperemia><Impairment><Implant><Inflammation><Intervention><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><J20><J20 mouse><Light><Link><Longitudinal Studies><Longitudinal Surveys><Memory><Memory Deficit><Memory Loss><Memory impairment><Methods><Mice><Mice Mammals><Microelectrodes><Microfluidics><Microscopy><Miniaturized Electrodes><Monitor><Murine><Mus><Nerve Degeneration><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Neuron Degeneration><O element><O2 element><Operative Procedures><Operative Surgical Procedures><Optics><Outcome><Oxygen><Paralysis Agitans><Parkinson><Parkinson Disease><Photoradiation><Physiologic Imaging><Primary Parkinsonism><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Public Health><Reporting><Resolution><Role><Secondary to><Specific qualifier value><Specified><Structure><Substantia Nigra><Substantia nigra structure><Surgical><Surgical Interventions><Surgical Procedure><Tauopathies><Techniques><Technology><Testing><Thallium><Therapeutic><Tissues><Tl element><Ultrasonic><Ultrasonics><Vascular Diseases><Vascular Disorder><Vasodilating Agent><Vasodilator Agents><Vasodilator Drugs><Vasodilators><Wild Type Mouse><Work><aged brain><ages><aging brain><alzheimer model><amyloid angiopathy><amyloid disease><amyloid pathology><aspirate><awake><biocompatibility><biological material><biomaterial compatibility><blood vessel disorder><brain visualization><design><designing><developmental><electrostimulation><endomicroscopy><endomicrosope><experiment><experimental research><experimental study><experiments><faces><facial><high resolution imaging><hippocampal><implantation><improved><indexing><innovate><innovation><innovative><insight><interest><lens><lenses><light microscopy><long-term study><longitudinal outcome studies><longitudinal research study><memory decline><memory dysfunction><microendoscope><microendoscopy><model of animal><molecular imaging><molecule imaging><mouse model><murine model><neural degeneration><neural stimulation><neurodegeneration><neurodegenerative><neurological degeneration><neurological disease><neuronal degeneration><neuropathologic tau><neuropathological tau><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><optical><optical fiber><pharmacologic><physiological imaging><prevent><preventing><primary degenerative dementia><resolutions><response><restoration><senile dementia of the Alzheimer type><site targeted delivery><social role><surgery><targeted delivery><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic target><timeline><tool><two photon excitation microscopy><two photon microscopy><two-photon><vascular><vascular amyloid><vascular amyloid accumulation><vascular amyloid build up><vascular amyloid deposition><vascular amyloid deposits><vascular amyloid pathology><vascular amyloidosis><vascular dysfunction><vasculopathy><wildtype mouse><µfluidic>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

HARALD W SONTHEIMER

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$683,028

FY 2026

Project Title

A fiber implant for long-term, deep-brain imaging and manipulation in mouse models of Alzheimer disease

Grant Number:

1R01AG095248-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Neurological disorders, such as Alzheimer disease (AD) and Parkinson disease, chronically affect critical regions of the deep brain, including the hippocampus and substantia nigra. Long-term monitoring of disease progression and responses to interventions in mouse models, which have ...

Research Terms

<2-photon><2-photon microscopy><AD dementia><AD model><Address><Affect><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimers Dementia><Ammon Horn><Amyloid><Amyloid Substance><Amyloidosis><Animal Model><Animal Models and Related Studies><Behavior><Behavioral><Biocompatible Materials><Biomaterials><Blood><Blood Reticuloendothelial System><Blood Tests><Blood Vessels><Blood flow><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain imaging><Brain region><Chronic><Cornu Ammonis><Development><Devices><Diameter><Disease Progression><Drug Delivery><Drug Delivery Systems><E-stim><Electric Stimulation><Encephalon><Encephalon Diseases><Evaluation><Face><Fiber><Functional Imaging><Goals><Hematologic Tests><Hematological Tests><Hematology Testing><Hippocampus><Histopathology><Hyperemia><Impairment><Implant><Inflammation><Intervention><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><J20><J20 mouse><Light><Link><Longitudinal Studies><Longitudinal Surveys><Memory><Memory Deficit><Memory Loss><Memory impairment><Methods><Mice><Mice Mammals><Microelectrodes><Microfluidics><Microscopy><Miniaturized Electrodes><Monitor><Murine><Mus><Nerve Degeneration><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Neuron Degeneration><O element><O2 element><Operative Procedures><Operative Surgical Procedures><Optics><Outcome><Oxygen><Paralysis Agitans><Parkinson><Parkinson Disease><Photoradiation><Physiologic Imaging><Primary Parkinsonism><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Public Health><Reporting><Resolution><Role><Secondary to><Specific qualifier value><Specified><Structure><Substantia Nigra><Substantia nigra structure><Surgical><Surgical Interventions><Surgical Procedure><Tauopathies><Techniques><Technology><Testing><Thallium><Therapeutic><Tissues><Tl element><Ultrasonic><Ultrasonics><Vascular Diseases><Vascular Disorder><Vasodilating Agent><Vasodilator Agents><Vasodilator Drugs><Vasodilators><Wild Type Mouse><Work><aged brain><ages><aging brain><alzheimer model><amyloid angiopathy><amyloid disease><amyloid pathology><aspirate><awake><biocompatibility><biological material><biomaterial compatibility><blood vessel disorder><brain visualization><design><designing><developmental><electrostimulation><endomicroscopy><endomicrosope><experiment><experimental research><experimental study><experiments><faces><facial><high resolution imaging><hippocampal><implantation><improved><indexing><innovate><innovation><innovative><insight><interest><lens><lenses><light microscopy><long-term study><longitudinal outcome studies><longitudinal research study><memory decline><memory dysfunction><microendoscope><microendoscopy><model of animal><molecular imaging><molecule imaging><mouse model><murine model><neural degeneration><neural stimulation><neurodegeneration><neurodegenerative><neurological degeneration><neurological disease><neuronal degeneration><neuropathologic tau><neuropathological tau><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><optical><optical fiber><pharmacologic><physiological imaging><prevent><preventing><primary degenerative dementia><resolutions><response><restoration><senile dementia of the Alzheimer type><site targeted delivery><social role><surgery><targeted delivery><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic target><timeline><tool><two photon excitation microscopy><two photon microscopy><two-photon><vascular><vascular amyloid><vascular amyloid accumulation><vascular amyloid build up><vascular amyloid deposition><vascular amyloid deposits><vascular amyloid pathology><vascular amyloidosis><vascular dysfunction><vasculopathy><wildtype mouse><µfluidic>

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Bistra Iordanova

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$664,619

FY 2026

Project Title

Multiscale Models of Age-Specific Neurometabolic Coupling

Grant Number:

1R01AG092661-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Cognition is intricately linked to the metabolic processes of the brain, yet existing computational models often overlook the metabolic costs associated with cognitive function. This oversight is critical, especially in neurodegenerative diseases like Alzheimer's, where metabolic dysfunctions play a...

Research Terms

<2-photon microscopy><AD biological marker><AD biomarker><AD dementia><AD model><AD pathway><AD related biomarker><AD-associated pathways><AD-related pathways><AD-specific pathways><Action Potentials><Address><Affect><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease model><Alzheimer's disease related biomarker><Alzheimer's mechanism><Alzheimer's related biomarker><Alzheimer's related pathways><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Amyloid><Amyloid Proteins><Amyloid Substance><Animal Model><Animal Models and Related Studies><Astrocytes><Astrocytus><Astroglia><Attention><Biological Markers><Blood capillaries><Blood erythrocyte><Brain><Brain Nervous System><Brain imaging><Budgets><Calcium><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Computer Models><Computerized Models><Coupling><Creatine><D-Glucose><DNA mutation><DWI (diffusion weighted imaging)><DWI-MRI><Data><Degenerative Neurologic Disorders><Dementia><Development><Dextrose><Differences between sexes><Differs between sexes><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Disturbance in cognition><Dysfunction><Early Diagnosis><Early Onset Familial Alzheimer's Disease><Encephalon><Equilibrium><Erythrocytes><Erythrocytic><Experimental Models><FDG PET><Female><Flavoproteins><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Genetic Change><Genetic defect><Genetic mutation><Glucose><Goals><Human><Hypoxia><Hypoxic><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Impaired cognition><Intermediary Metabolism><Intracellular Communication and Signaling><Investigation><Late Onset Alzheimer Disease><Late onset AD><Link><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Marrow erythrocyte><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metabolic><Metabolic Processes><Metabolic dysfunction><Metabolism><Mice><Mice Mammals><Microbeads><Microscopy><Microspheres><Mitochondria><Modeling><Modern Man><Modernization><Murine><Mus><Mutation><NMR Imaging><NMR Tomography><Nature><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic><Neurologic Degenerative Conditions><Neurological><Neurons><Neurosciences><Nuclear Magnetic Resonance Imaging><Obstruction><Optical reporter><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxygen Deficiency><Pathologic><Pattern><Performance><Physiopathology><Play><Population><Predisposition><Price><Primary Senile Degenerative Dementia><Property><Red Blood Cells><Red Cell><Research><Rest><Role><Sex Differences><Sexual differences><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Study models><Subgroup><Susceptibility><Testing><Therapeutic Intervention><Thermodynamic><Thermodynamics><Thinking><Traction><Validation><Vulnerable Populations><Zeugmatography><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged brain><ages><aging brain><alzheimer model><amyloid imaging><animal data><astrocytic glia><balance><balance function><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><blood corpuscles><blood oxygen level dependent><blood oxygenation level dependent><brain visualization><capillary><cerebral hypoperfusion><clinical relevance><clinically relevant><cognitive dysfunction><cognitive function><cognitive loss><cohort><computational modeling><computational models><computational network modeling><computer based models><computerized modeling><cost><dMRI><data integration><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><dementia risk><developmental><diffusion tensor imaging><early detection><extracellular><fMRI><familial AD><familial Alzheimer><familial Alzheimer disease><fluorodeoxyglucose PET><fluorodeoxyglucose positron emission tomography><genome mutation><hemodynamics><human data><imaging><in vivo><individualized therapeutic><insight><intervention therapy><late in life><late life><late onset alzheimer><mechanisms in AD><mechanisms in Alzheimer's disease><microtubule bound tau><microtubule-bound tau><mitochondrial><model of animal><mouse model><multi-modality><multi-scale computational modeling><multi-scale mathematical modeling><multi-scale modeling><multimodality><multiscale computational modeling><multiscale mathematical modeling><multiscale modeling><murine model><neglect><network models><neural><neural imaging><neuro-imaging><neurodegenerative illness><neuroimaging><neurological imaging><neuronal><novel><old age><overexpress><overexpression><pathophysiology><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><personalized therapeutic><potential biological marker><potential biomarker><prevent><preventing><pricing><primary degenerative dementia><risk factor for dementia><risk for dementia><senile dementia of the Alzheimer type><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><spatial and temporal><spatial temporal><spatiotemporal><tau><tau Proteins><tau factor><theories><thoughts><timeline><two photon excitation microscopy><two photon microscopy><validations><vulnerable group><vulnerable individual><vulnerable people><τ Proteins><♀>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

LIANG ZHAN

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$664,619

FY 2026

Project Title

Multiscale Models of Age-Specific Neurometabolic Coupling

Grant Number:

1R01AG092661-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Cognition is intricately linked to the metabolic processes of the brain, yet existing computational models often overlook the metabolic costs associated with cognitive function. This oversight is critical, especially in neurodegenerative diseases like Alzheimer's, where metabolic dysfunctions play a...

Research Terms

<2-photon microscopy><AD biological marker><AD biomarker><AD dementia><AD model><AD pathway><AD related biomarker><AD-associated pathways><AD-related pathways><AD-specific pathways><Action Potentials><Address><Affect><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease model><Alzheimer's disease related biomarker><Alzheimer's mechanism><Alzheimer's related biomarker><Alzheimer's related pathways><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Amyloid><Amyloid Proteins><Amyloid Substance><Animal Model><Animal Models and Related Studies><Astrocytes><Astrocytus><Astroglia><Attention><Biological Markers><Blood capillaries><Blood erythrocyte><Brain><Brain Nervous System><Brain imaging><Budgets><Calcium><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Computer Models><Computerized Models><Coupling><Creatine><D-Glucose><DNA mutation><DWI (diffusion weighted imaging)><DWI-MRI><Data><Degenerative Neurologic Disorders><Dementia><Development><Dextrose><Differences between sexes><Differs between sexes><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Disturbance in cognition><Dysfunction><Early Diagnosis><Early Onset Familial Alzheimer's Disease><Encephalon><Equilibrium><Erythrocytes><Erythrocytic><Experimental Models><FDG PET><Female><Flavoproteins><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Genetic Change><Genetic defect><Genetic mutation><Glucose><Goals><Human><Hypoxia><Hypoxic><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Impaired cognition><Intermediary Metabolism><Intracellular Communication and Signaling><Investigation><Late Onset Alzheimer Disease><Late onset AD><Link><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Marrow erythrocyte><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metabolic><Metabolic Processes><Metabolic dysfunction><Metabolism><Mice><Mice Mammals><Microbeads><Microscopy><Microspheres><Mitochondria><Modeling><Modern Man><Modernization><Murine><Mus><Mutation><NMR Imaging><NMR Tomography><Nature><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic><Neurologic Degenerative Conditions><Neurological><Neurons><Neurosciences><Nuclear Magnetic Resonance Imaging><Obstruction><Optical reporter><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxygen Deficiency><Pathologic><Pattern><Performance><Physiopathology><Play><Population><Predisposition><Price><Primary Senile Degenerative Dementia><Property><Red Blood Cells><Red Cell><Research><Rest><Role><Sex Differences><Sexual differences><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Study models><Subgroup><Susceptibility><Testing><Therapeutic Intervention><Thermodynamic><Thermodynamics><Thinking><Traction><Validation><Vulnerable Populations><Zeugmatography><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged brain><ages><aging brain><alzheimer model><amyloid imaging><animal data><astrocytic glia><balance><balance function><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><blood corpuscles><blood oxygen level dependent><blood oxygenation level dependent><brain visualization><capillary><cerebral hypoperfusion><clinical relevance><clinically relevant><cognitive dysfunction><cognitive function><cognitive loss><cohort><computational modeling><computational models><computational network modeling><computer based models><computerized modeling><cost><dMRI><data integration><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><dementia risk><developmental><diffusion tensor imaging><early detection><extracellular><fMRI><familial AD><familial Alzheimer><familial Alzheimer disease><fluorodeoxyglucose PET><fluorodeoxyglucose positron emission tomography><genome mutation><hemodynamics><human data><imaging><in vivo><individualized therapeutic><insight><intervention therapy><late in life><late life><late onset alzheimer><mechanisms in AD><mechanisms in Alzheimer's disease><microtubule bound tau><microtubule-bound tau><mitochondrial><model of animal><mouse model><multi-modality><multi-scale computational modeling><multi-scale mathematical modeling><multi-scale modeling><multimodality><multiscale computational modeling><multiscale mathematical modeling><multiscale modeling><murine model><neglect><network models><neural><neural imaging><neuro-imaging><neurodegenerative illness><neuroimaging><neurological imaging><neuronal><novel><old age><overexpress><overexpression><pathophysiology><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><personalized therapeutic><potential biological marker><potential biomarker><prevent><preventing><pricing><primary degenerative dementia><risk factor for dementia><risk for dementia><senile dementia of the Alzheimer type><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><spatial and temporal><spatial temporal><spatiotemporal><tau><tau Proteins><tau factor><theories><thoughts><timeline><two photon excitation microscopy><two photon microscopy><validations><vulnerable group><vulnerable individual><vulnerable people><τ Proteins><♀>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Costantino Iadecola

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$662,950

FY 2026

Project Title

Alzheimer Pathology and Neurovascular Dysfunction

Grant Number:

5R01NS037853-28

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/1998

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Alzheimer’s disease and related dementias (AD/ADRD) are leading causes of age-related cognitive impairment, currently untreatable. Increasing evidence indicates that functional alterations of the cerebral microcirculation may play a role in the pathogenesis of AD/ADRD by reducing the cerebral blood ...

Research Terms

<2-photon microscopy><AD and related dementia><AD pathology><AD related dementia><AD therapy><AD treatment><ADRD><Address><Age Years><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Alteplase><Alzheimer beta-Protein><Alzheimer disease treatment><Alzheimer treatment><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease and its related dementias><Alzheimer's amyloid><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease pathology><Alzheimer's disease related dementia><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's therapy><Amentia><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Aβ><Benign senescent forgetfulness><Blood Vessels><Blood capillaries><Blood flow><Body Tissues><Brain><Brain Nervous System><Brain Vascular><Brain imaging><Brain region><Burden on their caregivers><Caregiver Burden><Cell Communication and Signaling><Cell Signaling><Cerebrovascular Circulation><Cerebrum><Chronic><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Conscious><Consciousness><Consensus><Coupled><Coupling><D-Glucose><DNA mutation><Dementia><Development><Dextrose><Diagnostic><Disease><Disorder><Disturbance in cognition><EDRF Synthase><Educational workshop><Elderly><Encephalon><Endogenous Nitrate Vasodilator><Endothelium-Derived Growth Factor Synthase><Endothelium-Derived Nitric Oxide><Energy consumption><Event><FTD dementia><Failure><Frontal Temporal Dementia><Frontotemporal Dementia><Functional impairment><Funding><Genetic Change><Genetic defect><Genetic mutation><Glucose><Guanylyl Cyclase-Activating Factor Synthase><Health><Health Care Systems><Human><Hyperactivity><Hyperemia><Impaired cognition><Intracellular Communication and Signaling><Isoforms><Knowledge><Link><MAPT gene><MAPT protein><MT-bound tau><MTBT1><Mediating><Metabolic><Mice><Mice Mammals><Microcirculation><Modeling><Modern Man><Monitor><Mononitrogen Monoxide><Murine><Mus><Mutation><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><NIH><NMDA Receptor-Ionophore Complex><NMDA Receptors><NO Synthase><National Institutes of Health><Natural History><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuron Degeneration><Neurons><Neurovascular dysfunction><Nitric Oxide><Nitric Oxide Synthase><Nitric-Oxide Synthetase><Nitrogen Monoxide><Nitrogen Protoxide><Nutrient><O element><O2 element><Oxygen><Pathogenesis><Pathogenicity><Pathogenicity Factors><Penetration><Persons><Phosphorylation><Population><Production><Protein Isoforms><Protein Phosphorylation><Recombinant Tissue Plasminogen Activator><Regulation><Rest><Role><Signal Transduction><Signal Transduction Systems><Signaling><Starvation><Supplementation><T-Plasminogen Activator><Tauopathies><Testing><Therapeutic><Tissue Activator D-44><Tissue Plasminogen Activator><Tissue-Type Plasminogen Activator><Tissues><United States National Institutes of Health><Vascular Contributions to Alzheimer's Disease and Related Dementias><Vascular blood supply><Vasodilating Agent><Vasodilator Agents><Vasodilator Drugs><Vasodilators><Virulence Factors><Workshop><a beta peptide><aberrant tau><aberrant tau protein><abeta><abnormal tau><abnormal tau protein><advanced age><age associated cognitive impairment><age associated memory decline><age associated memory deficit><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related memory dysfunction><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><aging related cognitive decline><amyloid beta><amyloid-b protein><arteriole><awake><base><bases><beta amyloid associated pathology><beta amyloid fibril><beta amyloid pathology><biological signal transduction><blood flow in brain><blood supply><brain blood circulation><brain blood flow><brain health><brain oxygenation><brain visualization><burden in caregivers><burden of their caregivers><burden on caregivers><capillary><cerebral><cerebral blood flow><cerebral circulation><cerebral oxygenation><cerebral vascular><cerebro-vascular><cerebrocirculation><cerebrovascular><cerebrovascular blood flow><cerebrovascular contributions to ADRD><cognitive defects><cognitive disability><cognitive dysfunction><cognitive function><cognitive loss><cognitively disabled><declining cognitive functions with aging><developmental><endothelial cell derived relaxing factor><front temporal dementia><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><genome mutation><geriatric><imaging approach><imaging based approach><in vivo><microtubule associated protein tau><microtubule associated protein tau mutation><microtubule bound tau><microtubule-associated protein tau><microtubule-associated protein tau mutation><microtubule-bound tau><mutant tau><mutant tau protein><mutation in microtubule associated protein tau><mutation in microtubule-associated protein tau><neocortical><neural><neural degeneration><neural network><neuro-vascular><neuro-vascular coupling><neurodegeneration><neurodegenerative><neurological degeneration><neuronal><neuronal degeneration><neuropathologic tau><neuropathological tau><neurovascular><neurovascular abnormality><neurovascular coupling><neurovascular dysregulation><neurovascular impairment><neurovascular pathology><neurovasculopathy><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><p-tau><p-τ><pathogenic tau><pathogenic tau gene mutation><pathogenic tau protein><pathological change in tau><pathological tau><pathological tau protein><phospho-tau><phospho-τ><phosphorylated tau><post-translational modification of tau><posttranslational modification of tau><response><senior citizen><sensor><sex><social role><soluble amyloid precursor protein><t-PA><tau><tau Proteins><tau abnormality><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau intronic mutation><tau mediated neurodegeneration><tau mutation><tau neurodegenerative disease><tau neuropathology><tau pathological change><tau pathology><tau pathophysiology><tau phosphorylation><tau posttranslational modification><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><tissue oxygen saturation><tissue oxygenation><two photon excitation microscopy><two photon microscopy><vascular><vascular contributions to AD/ADRD><vascular contributions to ADRD><vascular supply><whole health><whole person health><β-amyloid pathology><τ Proteins><τ mutation><τ phosphorylation>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Toni R. Pak

LOYOLA UNIVERSITY CHICAGO, MAYWOOD, IL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$653,367

FY 2026

Project Title

Sex-specific regulation of microRNAs in Alzheimer Disease

Grant Number:

5R01AG082135-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Alzheimer’s Disease is more prevalent in women than men, yet a biological basis for this sex difference is not understood. The primary objective of this proposal is to understand how 17β-estradiol (E2) regulates microRNA (miR) biogenesis and stability across the lifespan and in Alzhe...

Research Terms

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Wang-Xia Wang

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$651,889

FY 2026

Project Title

MicroRNA lipid-nanoparticle based therapy targets neuroinflammation and ApoE dysregulation in Alzheimer’s disease

Grant Number:

5R01AG082142-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Title: MicroRNA lipid-nanoparticle based therapy targets neuroinflammation and ApoE dysregulation in Alzheimer’s disease Abstract MicroRNAs (miRNA) are small non-coding regulatory RNA that have large impacts in health and disease. While prior studies have implicated miRNA in Alzheimer’s dise...

Research Terms

<40-C-EBP Protein><AD dementia><AD pathology><AD risk><AD risk factor><AD therapy><AD treatment><AGP-EBP Transcription Factor><APOE><Acquired brain injury><Acute><Affect><Age><Aging><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's therapy><Alzheimers Dementia><Amentia><Amyloid (Aβ) plaques><Amyloid Plaques><Apo-E><ApoE protein><Apolipoprotein E><Basal Transcription Factor><Basal transcription factor genes><Behavioral Assay><Biochemical><Biological><Bone Marrow><Bone Marrow Reticuloendothelial System><Brain><Brain Injuries><Brain Nervous System><C-EBP-Related Protein 2><C-EBP-beta><C-EBP-β><C-EBPbeta><C-EBPβ><CCAAT-Enhancer-Binding Protein-beta><CCAAT-Enhancer-Binding Protein-β><CRP2 Protein><Cell Body><Cell Communication and Signaling><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Signaling><Cells><Data><Dementia><Disease><Disorder><Disproportionate number of females><Disproportionate number of women><Disproportionately affects females><Disproportionately affects women><Disproportionately impacts females><Disproportionately impacts women><Disproportionately in females><Disproportionately in women><Encephalon><Event><Female><Functional RNA><Funding><General Transcription Factor Gene><General Transcription Factors><Genotype><Goals><Health><Histologic><Histologically><Hortega cell><Human><Human X Chromosome><IL-6 DBP><IL-6-Dependent DNA Binding Protein><In Vitro><Inflammation><Inflammatory><Inflammatory Response><Injury><Interleukin-6 Nuclear Factor><Intracellular Communication and Signaling><Intravenous><KO mice><Kentucky><Knock-out Mice><Knockout Mice><Knowledge><LAP Transcription Factor><Late Onset Alzheimer Disease><Late onset AD><Link><Liposomal><Liposomes><Macrophage><Mediating><Methods><Mice><Mice Mammals><MicroRNAs><Microglia><Modeling><Modern Man><Molecular><Murine><Mus><Myeloid Cells><Mφ><NF-IL6><Nerve Degeneration><Nervous System Physiology><Neuritic Plaques><Neurologic function><Neurological function><Neuron Degeneration><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Null Mouse><Pathology><Pathway interactions><Primary Senile Degenerative Dementia><Proteins><Public Health><RNA><RNA Gene Products><Regulation><Ribonucleic Acid><Role><Sampling><Senile Plaques><Signal Transduction><Signal Transduction Systems><Signaling><System><Testing><Therapeutic><Therapeutically Targetable><Transcription Factor Proto-Oncogene><Transcription factor genes><Universities><Untranslated RNA><X Chromosome><aged><aged mice><aged mouse><ages><alzheimer risk><amyloid beta plaque><amyloid-b plaque><aβ plaques><biobank><biologic><biological signal transduction><biorepository><brain cell><brain damage><brain tissue><brain-injured><cell sorting><cored plaque><diffuse plaque><efficacy testing><elderly mice><female bias><female predominance><female preponderance><gitter cell><improved><in vivo><injuries><innovate><innovation><innovative><late onset alzheimer><lipid based nanoparticle><lipid nanoparticle><liposomal delivery><liposome delivery><male><mesoglia><miR therapy><miR-based therapeutic><miR-based therapy><miRNA><miRNA delivery><miRNA therapy><miRNA-based therapeutic><miRNA-based therapy><microRNA delivery><microRNA therapy><microRNA-based therapeutic><microRNA-based therapy><microglial cell><microgliocyte><mouse model><murine model><nervous system function><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal degeneration><neuropathologic><neuropathological><neuropathology><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><noncoding><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><old mice><pathway><perivascular glial cell><predominance in females><predominance in women><primary degenerative dementia><protein biomarkers><protein markers><response><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sex><sex dimorphism><sexual dimorphism><sexually dimorphic><social role><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic miRNA><therapeutic miRs><therapeutic microRNA><transcription factor><women's predominance><women's preponderance><♀><♂>

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Yinglong Miao

UNIVERSITY OF KANSAS LAWRENCE, LAWRENCE, KS

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$643,210

FY 2026

Project Title

Structure and Function of Gamma-Secretase in Alzheimer's Disease

Grant Number:

2R01AG066986-06A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Alzheimer’s disease (AD) is characterized pathologically by cerebral plaques of amyloid β-peptide (Aβ). The amyloid hypothesis posits that Aβ, particularly the aggregation-prone 42-residue form (Aβ42), triggers a cascade of events culminating in neuronal loss and dementia. Aβ is pro...

Research Terms

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Michael S Wolfe

UNIVERSITY OF KANSAS LAWRENCE, LAWRENCE, KS

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$643,210

FY 2026

Project Title

Structure and Function of Gamma-Secretase in Alzheimer's Disease

Grant Number:

2R01AG066986-06A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2020

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Alzheimer’s disease (AD) is characterized pathologically by cerebral plaques of amyloid β-peptide (Aβ). The amyloid hypothesis posits that Aβ, particularly the aggregation-prone 42-residue form (Aβ42), triggers a cascade of events culminating in neuronal loss and dementia. Aβ is pro...

Research Terms

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Hongwei Qin

AUGUSTA UNIVERSITY, AUGUSTA, GA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$641,097

FY 2026

Project Title

Astrocytic OSMR/JAK/STAT signaling in AD

Grant Number:

5R01AG075057-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The role of reactive astrocytes in Alzheimer’s disease (AD) pathogenesis remains largely understudied. Little is known about how astrocytes change their functions/properties under different reactive states and what consequences such changes cause under pathological conditions. The JAK/STAT pathway i...

Research Terms

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Qin Wang

AUGUSTA UNIVERSITY, AUGUSTA, GA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$641,097

FY 2026

Project Title

Astrocytic OSMR/JAK/STAT signaling in AD

Grant Number:

5R01AG075057-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The role of reactive astrocytes in Alzheimer’s disease (AD) pathogenesis remains largely understudied. Little is known about how astrocytes change their functions/properties under different reactive states and what consequences such changes cause under pathological conditions. The JAK/STAT pathway i...

Research Terms

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Mohanish P Deshmukh

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$633,496

FY 2026

Project Title

miR-29: A brain homeostasis molecule for Alzheimer’s disease prevention

Grant Number:

5R01AG082140-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary One of the underexplored aspects of neuronal biology is that as postmitotic neurons become mature, they undergo dynamic changes to ensure that the mature nervous system is capable of long-term survival and function. Understanding these mechanisms that are critical for the long-term ...

Research Terms

<21+ years old><A β-42><A β42><A-beta 42><A-beta42><AAV delivered><AAV delivery><AAV vector><AAV-based delivery><AAV-based vector><AAV-based viral delivery><AAV-mediated delivery><AD dementia><AD model><AD pathology><AD pathway><AD patients><AD prevention><AD-associated pathways><AD-related pathways><AD-specific pathways><Abeta synthesis><Abeta-42><Abeta42><Acquired brain injury><Adeno-associated-virus-based delivery><Adult><Adult Human><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer disease prevention><Alzheimer pathway><Alzheimer prevention><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's mechanism><Alzheimer's pathology><Alzheimer's patient><Alzheimer's related pathways><Alzheimers Dementia><Amyloid><Amyloid Substance><Amyloid beta-42><Amyloid beta42><Amyloid β production><Amyloid β synthesis><Amyloid β-42><Amyloid β42><Amyloidβ-42><Amyloidβ42><Autoregulation><Aβ production><Aβ synthesis><Aβ-42><Aβ42><BACE><BACE1><Behavior><Biology><Birth><Brain><Brain Diseases><Brain Disorders><Brain Injuries><Brain Nervous System><Cerebellum><DNA Methylation><DNMT3a><Defect><Degenerative Neurologic Disorders><Dendritic Spines><Development><Disease><Disorder><Dysfunction><EC 2.1.1><Embryo><Embryonic><Encephalon><Encephalon Diseases><Event><Exhibits><FYN><FYN gene><FYN oncogene related to SRC, FGR, YES><Family><Functional disorder><Gene Down-Regulation><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Genes><Homeostasis><Hypermethylation><Individual><Injury><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><MT-bound tau><Maintenance><Methylation><Methyltransferase><Mice><Mice Mammals><MicroRNAs><Modeling><Morphology><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic><Neurologic Body System><Neurologic Degenerative Conditions><Neurologic Organ System><Neurological><Neuron Degeneration><Neuronal Differentiation><Neurons><Organoids><Outcome><Parturition><Pathway interactions><Pattern><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Pre-Clinical Model><Preclinical Models><Primary Senile Degenerative Dementia><Proteins><Repression><SLK gene><SLK protein><SYN gene><SYN protein><Sampling><Synapses><Synaptic><Testing><Therapeutic><Transcript Expression Analyses><Transcript Expression Analysis><Transcription Repression><Treatment Efficacy><abeta accumulation><abeta aggregation><abeta production><adeno-associated viral vector><adeno-associated viral vector delivery><adeno-associated virus delivery><adeno-associated virus mediated delivery><adeno-associated virus vector><adenovirus mediated delivery><adulthood><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age related neurodegeneration><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><aging associated neurodegeneration><aging associated neurodegenerative disease><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><alzheimer model><amyloid beta accumulation><amyloid beta aggregation><amyloid beta production><amyloid beta synthesis><amyloid β accumulation><amyloid β aggregation><analyze gene expression><aβ accumulation><aβ aggregation><beta-secretase 1><beta-site APP cleaving enzyme 1><beta-site amyloid precursor protein cleaving enzyme 1><brain damage><brain-injured><cell type><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><delivered with AAV><delivery with AAV><dendrite spine><developmental><disease phenotype><experiment><experimental research><experimental study><experiments><gene expression analysis><gene expression assay><gene repression><hDNA methyltransferase 3a><healthy aging><healthy human aging><human progenitor><human stem cells><hyper-phosphorylated tau><hyperphosphorylated tau><injuries><intervention efficacy><mechanisms in AD><mechanisms in Alzheimer's disease><memapsin 2><member><methylase><miRNA><microtubule bound tau><microtubule-bound tau><mouse model><murine model><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><neurotoxic><overexpress><overexpression><pathophysiology><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><postmitotic><pre-clinical><preclinical><primary degenerative dementia><progenitor cell model><progenitor model><resilience><resilient><restoration><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><synapse><tau><tau Proteins><tau factor><therapeutic efficacy><therapy efficacy><transcriptional profiling><transmethylase><β-secretase 1><β-site APP cleaving enzyme 1><τ Proteins>

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Le Cong

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$618,688

FY 2026

Project Title

Combinatorial Perturbation with Multi-Omics Readout to Dissect Etiology of Alzheimer's Disease Using Stem Cell and In Vivo Models

Grant Number:

5R01AG091819-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Combinatorial Perturbation with Multi-Omics Readout to Dissect Etiology of Alzheimer's Disease Using Stem Cell and In Vivo Models Abstract Alzheimer's disease (AD) is a prevalent age-related neurodegenerative disorder. While early-onset AD is driven by well-characterized genes, the mechanistic links...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AAV delivered><AAV delivery><AAV-based delivery><AAV-based viral delivery><AAV-mediated delivery><ABCA1><ABCA1 protein><AD dementia><AD model><AD risk><AD risk factor><AD therapy><AD treatment><APOE><ATP binding cassette transporter 1><Adeno-associated-virus-based delivery><Affect><Age><Aged 65 and Over><Aging><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's diagnosis><Alzheimer's disease diagnosis><Alzheimer's disease model><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's therapy><Alzheimers Dementia><Animal Model><Animal Models and Related Studies><Apo-E><ApoE protein><Apolipoprotein E><Apoptosis-Related Cysteine Protease Caspase 7><Apoptosis-Related Cysteine Protease Gene Caspase 7><Apoptotic Protease MCH-3 Gene><Apoptotic Protease Mch-3><Automobile Driving><Bacteriophages><Brain><Brain Nervous System><CASP7><CASP7 gene><CASP7 protein><CMH-1><CRISPR approach><CRISPR based approach><CRISPR library><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based library><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 library><CRISPR/Cas9 technology><Cas nuclease technology><Caspase-7 Gene><Causality><Cell model><Cellular model><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats library><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complex><Computational Biology><DNA Alteration><DNA Sequence Alteration><Data><Data Set><Degenerative Neurologic Disorders><Development><Diagnosis><Diathesis><Disease><Disease susceptibility><Disorder><Disturbance in cognition><EOAD><Early Onset Alzheimer Disease><Encephalon><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Family><Gene variant><Genes><Genetic><Genetic Alteration><Genetic Diseases><Genetic study><Genome><HDLDT1><Heritability><HuBMAP><Human><Human BioMolecular Atlas Program><Human Genetics><ICE-LAP3><ICE-LAP3 Gene><ICE-Like Apoptotic Protease 3><ICE-Like Apoptotic Protease 3 Gene><Impaired cognition><Individual><Investigators><Label><Late Onset Alzheimer Disease><Late onset AD><Light><Link><MCH3><Memory Loss><Modeling><Modern Man><Mouse Strains><Multiomic Data><NIH><National Institutes of Health><Nerve Degeneration><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Older Population><Onset of illness><Pathogenesis><Patients><Phages><Phosphoproteins><Photoradiation><Primary Senile Degenerative Dementia><Progenitor Cells><Proteins><Research Personnel><Research Resources><Researchers><Resources><Risk Factors><Risk-associated variant><Sequence Alteration><Series><Shapes><Societies><Symptoms><System><TREM2><TREM2 gene><Technology><Testing><Time><Transgenic Organisms><Triggering Receptor Expressed in Myeloid Cells 2><Triggering Receptor Expressed on Myeloid Cells 2><United States National Institutes of Health><Work><above age 65><adeno-associated viral vector delivery><adeno-associated virus delivery><adeno-associated virus mediated delivery><adenovirus mediated delivery><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age of 65 years onward><age related neurodegeneration><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><aged 65 and greater><aged 65+><aged ≥65><ages><aging associated disease><aging associated disorders><aging associated neurodegeneration><aging associated neurodegenerative disease><aging process><aging related disease><aging related disorders><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><allelic variant><alzheimer model><alzheimer risk><bacterial virus><caspase-7><causation><cell type><cholesterol-efflux regulatory protein><cognitive dysfunction><cognitive loss><combinatorial><computer biology><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><delivered with AAV><delivery vector><delivery vehicle><delivery with AAV><developmental><disability><disease associated with aging><disease causation><disease of aging><disease onset><disorder of aging><disorder onset><disorders associated with aging><disorders related to aging><driving><early onset><early onset AD><early onset Alzheimer's><epigenetically><functional genomics><genetic condition><genetic disorder><genetic variant><genomic alteration><genomic variant><global gene expression><global transcription profile><hallmarks of aging><human old age (65+)><human progenitor><human stem cells><in vivo><in vivo Model><innovate><innovation><innovative><insight><late onset alzheimer><liability to disease><memory decline><model of animal><multiomics><multiple omic data><multiple omics><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal degeneration><novel><older adult><older adulthood><older groups><older individuals><older person><over 65 years><panomics><pillars of aging><primary degenerative dementia><prime editing><progenitor cell model><progenitor model><protective allele><protective variant><risk allele><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk gene><risk genotype><risk loci><risk locus><risk of developing Alzheimer's><risk variant><senile dementia of the Alzheimer type><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stem cells><synergism><tool><transcriptome><transgenic><vector><≥65 years>

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Gregory Bowman

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$606,541

FY 2026

Project Title

Structural basis for ApoE4-induced Alzheimer's disease

Grant Number:

5R01AG067194-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2021

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Alzheimer's disease (AD) is the 6th leading cause of death in the USA and there are no effective treatments. Moreover, the prevalence of this age-related neurodegenerative disease is likely to increase as the US population ages. Therefore, there is a great need to understand AD and develop therapeut...

Research Terms

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TERUNA J. SIAHAAN

UNIVERSITY OF KANSAS LAWRENCE, LAWRENCE, KS

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$590,023

FY 2026

Project Title

Reshaping ApoE4 and Alzheimer's Brains with ApoE2

Grant Number:

5R01AG071682-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2022

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The research we propose in this application seeks to translate our recent understanding of the neuroprotective mechanism associated with the human apolipoprotein E2 (ApoE2) genotype into a therapeutic opportunity to prevent and treat Alzheimer's disease (AD). The overarching hypothes...

Research Terms

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Liqin Zhao

UNIVERSITY OF KANSAS LAWRENCE, LAWRENCE, KS

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$590,023

FY 2026

Project Title

Reshaping ApoE4 and Alzheimer's Brains with ApoE2

Grant Number:

5R01AG071682-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2022

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The research we propose in this application seeks to translate our recent understanding of the neuroprotective mechanism associated with the human apolipoprotein E2 (ApoE2) genotype into a therapeutic opportunity to prevent and treat Alzheimer's disease (AD). The overarching hypothes...

Research Terms

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Andrew ASCHENBRENNER

UNIVERSITY OF KANSAS MEDICAL CENTER, KANSAS CITY, KS

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$589,614

FY 2026

Project Title

CoMTAD: Cognitive Monitoring during Treatment for Alzheimer disease

Grant Number:

1R01AG091310-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY There are now anti-amyloid therapies available to slow the clinical progression of Alzheimer’s disease (AD). These therapies come with the risk of negative side-effects including amyloid related imaging abnormalities (ARIA). Little is known about acute and long-term cognitive consequ...

Research Terms

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Jasmeet Pannu Hayes

OHIO STATE UNIVERSITY, Columbus, OH

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$581,198

FY 2026

Project Title

Neuroimaging and molecular markers of AD and neurodegenerative disease after concussion

Grant Number:

2R01AG058822-06A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2019

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Traumatic Brain Injury (TBI) has emerged as a significant risk factor for Alzheimer's Disease (AD) and related dementias. Epidemiological studies indicate that mild TBI more than doubles the risk for dementia; however, the mechanisms underlying this association remain poorly...

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YU YAMAGUCHI

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$580,960

FY 2026

Project Title

Microglial heparan sulfate in the modulation of APOE function and neurodegeneration

Grant Number:

5R01AG072468-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Heparan sulfate (HS), a sulfated glycan expressed at the cell surface and in extracellular matrix, has long attracted attention as a putative factor involved in Alzheimer's disease (AD), based on circumstantial evidence from in vitro and clinicopathological studies. Nevertheless, the functional sign...

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Bryan David James

RUSH UNIVERSITY MEDICAL CENTER, CHICAGO, IL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$575,478

FY 2026

Project Title

Predictors and consequences of the timing and accuracy of clinical dementia diagnosis

Grant Number:

5R01AG072559-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The overarching goal of this project is to develop the evidence base around the predictors and consequences of clinical underdiagnosis vs early clinical diagnosis of Alzheimer’s disease and related dementias (ADRD) in healthcare settings. Many older persons who would meet diagnostic criteria for dem...

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Roberto Zoncu

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$571,247

FY 2026

Project Title

Deciphering and disabling lysosome-dependent mechanisms of neurodegeneration

Grant Number:

5R01NS133575-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The survival of neuronal cells critically depends on the correct function of their lysosomes, catabolic organelles that play key roles in disposing damaged and harmful cellular components. Niemann-Pick type C (NPC) is a neurodegenerative and metabolic disease triggered by mutations of the NPC1 gene,...

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ATHANASSIOS SIAPAS

CALIFORNIA INSTITUTE OF TECHNOLOGY, PASADENA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$567,159

FY 2026

Project Title

Dopaminergic Modulation of Hippocampal-Cortical Interactions in Learning

Grant Number:

5R01NS135465-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The hippocampus plays a critical role in the formation of episodic memories. The current predominant hypothesis is that memories are gradually established across distributed cortical networks under the influence of hippocampal activity. Dopamine influences memory processing by signal...

Research Terms

<2-photon><AD dementia><Acceleration><Address><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Ammon Horn><Animals><Area><Association Learning><Associative Learning><Auditory><Auditory Cortex><Auditory area><Automobile Driving><Axon><Behavior><Behavioral><Brain><Brain Nervous System><Calcium><Cell Communication and Signaling><Cell Signaling><Chemosensitization><Chemosensitization/Potentiation><Cognitive Retention Disorders><Complex><Cornu Ammonis><Data><Decision Making><Delta Wave><Delta Wave sleep><Dopamine><EPSP><Elements><Encephalon><Episodic memory><Event><Evolution><Excitatory Postsynaptic Potentials><Fiber><Foundations><Hippocampus><Hydroxytyramine><Image><Injections><Intracellular Communication and Signaling><Learning><Light><Location><Measurement><Measures><Memory><Memory Disorders><Motivation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Output><Pathway interactions><Pavlovian conditioning><Phase><Photoradiation><Play><Potentiation><Primary Senile Degenerative Dementia><Process><Punishment><Research><Rewards><Role><Signal Transduction><Signal Transduction Systems><Signaling><Site><Sleep><Slow-Wave Sleep><Stimulus><Structure><Synapses><Synaptic><Testing><Wakefulness><Whole-Cell Recordings><associative conditioning><auditory stimulus><biological signal transduction><classical conditioning><driving><experiment><experimental research><experimental study><experiments><extracellular><hippocampal><image registration><imaging><in vivo><memory consolidation><memory encoding><memory process><memory processing><memory recall><motivated behavior><neocortical><neural><neural control><neural regulation><neuromodulation><neuromodulatory><neuronal><neuroregulation><optogenetics><pathway><pharmacologic><primary degenerative dementia><response><senile dementia of the Alzheimer type><signal processing><social role><synapse><two-photon>

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Anna Fracassi

UNIVERSITY OF TEXAS MED BR GALVESTON, GALVESTON, TX

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$564,098

FY 2026

Project Title

Microglia and Tau Oligomer Polymorphs Interplay in Cognitive Resilience in Alzheimers disease

Grant Number:

1R01AG097537-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is the most common and severe form of neurodegenerative disorder, affecting nearly 50 million people worldwide, for which there is still no resolving cure. Identifying novel, effective therapeutic strategies for AD is therefore urgent. The existence ...

Research Terms

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Kei M Igarashi

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$562,599

FY 2026

Project Title

Understanding output circuits of the lateral entorhinal cortex

Grant Number:

5R01MH137156-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/17/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract The entorhinal cortex (EC) and the hippocampus are the brain areas which are critically involved in the formation and retrieval of declarative memory, and damage to this circuit results in memory impairment. In order to cure dementias, including Alzheimer’s disease which currently affects 6...

Research Terms

<5-HT><5-Hydroxytryptamine><5HT><AD dementia><Address><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Ammon Horn><Anatomic Sites><Anatomic structures><Anatomy><Area><Association Learning><Associative Learning><Axon><Back><Brain><Brain Nervous System><Brain region><Cell Body><Cells><Common Rat Strains><Communication><Cornu Ammonis><Cues><Data><Dementia><Dimensions><Dopamine><Dorsal><Dorsum><Electrophysiology><Electrophysiology (science)><Encephalon><Enteramine><Entorhinal Area><Environment><Goals><Hippocampus><Hippophaine><Hydroxytyramine><Image><Individual><Knowledge><Lateral><Learning><Medial><Memory><Memory Deficit><Memory impairment><Methods><Mice><Mice Mammals><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Odors><Outcome><Output><Pathogenesis><Pavlovian conditioning><Persons><Photometry><Physiologic><Physiological><Plasma Retinol-Binding Protein><Play><Position><Positioning Attribute><Prefrontal Cortex><Primary Senile Degenerative Dementia><Process><Public Health><Punishment><RBP4><RBP4 gene><Rat><Rats Mammals><Rattus><Research><Retinol-Binding Protein 4><Retrieval><Rewards><Role><Sensory><Serotonin><Structure><Testing><Transgenic Mice><United States><Ventral Tegmental Area><analytical method><associative conditioning><cell type><classical conditioning><electrophysiological><entorhinal cortex><hippocampal><imaging><in vivo><memory dysfunction><memory retrieval><neural control><neural regulation><neuromodulation><neuromodulatory><neuronal><neuroregulation><novel><optogenetics><pharmacologic><primary degenerative dementia><promoter><promotor><segregation><senile dementia of the Alzheimer type><social role><spatial memory><spatial navigation><ventral tegmentum><way finding><wayfinding>

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Heng Du

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$551,382

FY 2026

Project Title

GOAT-mediated ghrelin deregulation and hippocampal pathology in Alzheimer's Disease

Grant Number:

7R01AG059753-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2018

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary: Hippocampal lesions constitute a characteristic brain pathology underlying memory loss in both familial and sporadic Alzheimer’s disease (AD). Ghrelin, a stomach-produced, acylated peptide hormone, is the endogenous agonist of growth hormone secretagogue receptor (GHSR, also known a...

Research Terms

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Gao Wang

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$548,357

FY 2026

Project Title

Multiomics data integration methods to discover putative causal variants, genes and patient heterogeneity for Alzheimers disease

Grant Number:

5R01AG076901-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Despite the success of genome-wide association studies (GWAS) in identifying over 70 susceptibility loci for Late-onset (LO) Alzheimer’s disease (AD), AD related disease and endophenotypes, it remains challenging to pinpoint 1) which are truly causal AD variants; 2) the molecular pro...

Research Terms

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Blaine Russell Roberts

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$547,556

FY 2026

Project Title

Deciphering the IgG glycosylation code of Alzheimer's Disease

Grant Number:

5R01AG085587-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Antibodies are critical components of the adaptive immune system. While their simplest mechanism of action is neutralization mediated by their hypervariable Fab domains, most of their functional effects are a result of their constant Fc domains engaging host Fc receptors to recruit and stimulate the...

Research Terms

<2-dimensional><7S Gamma Globulin><AD dementia><AD patients><AD therapy><AD treatment><Adaptive Immune System><Address><Affinity><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's disease patient><Alzheimer's disease therapy><Alzheimer's patient><Alzheimer's therapy><Alzheimers Dementia><Amino Acid Sequence><Amyloid><Amyloid Substance><Antibodies><Binding><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Serum><Brain><Brain Nervous System><C1 q><C1q><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cells><Cerebrospinal Fluid><Chemical Structure><Chemicals><Clinical Treatment Moab><Code><Coding System><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complement 1q><Complement C1q><Constant Region><Disease><Disorder><Dissociation><Disturbance in cognition><Electrons><Encephalon><Exhibits><Fab domain><Fc Receptor><Fc domain><Gender><Gene variant><Glycans><Glycopeptides><Glycoproteins><Human><Ig Constant Region><IgG><IgG Receptors><IgG1><IgG2><IgG3><IgG4><Image><Immune Globulins><Immune response><Immune system><Immunochemical Immunologic><Immunoglobulin Constant Region><Immunoglobulin G><Immunoglobulin G Receptor><Immunoglobulins><Immunologic><Immunologic Stimulation><Immunological><Immunological Stimulation><Immunologically><Immunologics><Immunostimulation><Impaired cognition><Individual><Inflammation><Inflammatory><Intracellular Communication and Signaling><Ions><Light><Link><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measurement><Measures><Mediating><Metabolic Glycosylation><Methods><Modern Man><Molecular><Molecular Interaction><Monitor><Monoclonal Antibodies><Negative Beta Particle><Negatrons><Onset of illness><Patients><Peptides><Photoradiation><Plasma><Plasma Serum><Polysaccharides><Preparation><Primary Protein Structure><Primary Senile Degenerative Dementia><Property><Proteins><Protomer><Race><Races><Receptor Protein><Research><Reticuloendothelial System, Serum, Plasma><Sampling><Serum><Severity of illness><Signal Transduction><Signal Transduction Systems><Signaling><Techniques><Technology><Time><Vaccines><Work><acquired immune system><ages><allelic variant><analyzing longitudinal><antibody receptor><biological signal transduction><cell culture><cell cultures><cerebral spinal fluid><cognitive dysfunction><cognitive loss><cohort><disease onset><disease severity><disorder onset><gamma Fc Receptors><genetic variant><genomic variant><glycosylated IgG><glycosylated immunoglobulin G><glycosylation><host response><imaging><immune system response><immunoresponse><individual patient><inflammation marker><inflammatory marker><innovate><innovation><innovative><liquid chromatography mass spectroscopy><longitudinal analysis><mAbs><monoclonal Abs><novel><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><preparations><primary degenerative dementia><protein sequence><racial><racial background><racial origin><receptor><receptor binding><receptor bound><recruit><senile dementia of the Alzheimer type><side effect><spinal fluid><sugar><tool><two-dimensional>

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ERIC JOHN SUNDBERG

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$547,556

FY 2026

Project Title

Deciphering the IgG glycosylation code of Alzheimer's Disease

Grant Number:

5R01AG085587-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Antibodies are critical components of the adaptive immune system. While their simplest mechanism of action is neutralization mediated by their hypervariable Fab domains, most of their functional effects are a result of their constant Fc domains engaging host Fc receptors to recruit and stimulate the...

Research Terms

<2-dimensional><7S Gamma Globulin><AD dementia><AD patients><AD therapy><AD treatment><Adaptive Immune System><Address><Affinity><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's disease patient><Alzheimer's disease therapy><Alzheimer's patient><Alzheimer's therapy><Alzheimers Dementia><Amino Acid Sequence><Amyloid><Amyloid Substance><Antibodies><Binding><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Serum><Brain><Brain Nervous System><C1 q><C1q><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cells><Cerebrospinal Fluid><Chemical Structure><Chemicals><Clinical Treatment Moab><Code><Coding System><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complement 1q><Complement C1q><Constant Region><Disease><Disorder><Dissociation><Disturbance in cognition><Electrons><Encephalon><Exhibits><Fab domain><Fc Receptor><Fc domain><Gender><Gene variant><Glycans><Glycopeptides><Glycoproteins><Human><Ig Constant Region><IgG><IgG Receptors><IgG1><IgG2><IgG3><IgG4><Image><Immune Globulins><Immune response><Immune system><Immunochemical Immunologic><Immunoglobulin Constant Region><Immunoglobulin G><Immunoglobulin G Receptor><Immunoglobulins><Immunologic><Immunologic Stimulation><Immunological><Immunological Stimulation><Immunologically><Immunologics><Immunostimulation><Impaired cognition><Individual><Inflammation><Inflammatory><Intracellular Communication and Signaling><Ions><Light><Link><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measurement><Measures><Mediating><Metabolic Glycosylation><Methods><Modern Man><Molecular><Molecular Interaction><Monitor><Monoclonal Antibodies><Negative Beta Particle><Negatrons><Onset of illness><Patients><Peptides><Photoradiation><Plasma><Plasma Serum><Polysaccharides><Preparation><Primary Protein Structure><Primary Senile Degenerative Dementia><Property><Proteins><Protomer><Race><Races><Receptor Protein><Research><Reticuloendothelial System, Serum, Plasma><Sampling><Serum><Severity of illness><Signal Transduction><Signal Transduction Systems><Signaling><Techniques><Technology><Time><Vaccines><Work><acquired immune system><ages><allelic variant><analyzing longitudinal><antibody receptor><biological signal transduction><cell culture><cell cultures><cerebral spinal fluid><cognitive dysfunction><cognitive loss><cohort><disease onset><disease severity><disorder onset><gamma Fc Receptors><genetic variant><genomic variant><glycosylated IgG><glycosylated immunoglobulin G><glycosylation><host response><imaging><immune system response><immunoresponse><individual patient><inflammation marker><inflammatory marker><innovate><innovation><innovative><liquid chromatography mass spectroscopy><longitudinal analysis><mAbs><monoclonal Abs><novel><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><preparations><primary degenerative dementia><protein sequence><racial><racial background><racial origin><receptor><receptor binding><receptor bound><recruit><senile dementia of the Alzheimer type><side effect><spinal fluid><sugar><tool><two-dimensional>

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Linda Valeri

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$544,303

FY 2026

Project Title

Bayesian Statistical Learning for Robust and Generalizable Causal Inferences in Alzheimer Disease and Related Disorders Research

Grant Number:

5R01AG077518-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY To develop multi-faceted interventions for Alzheimer’s Disease and Related Disorders (ADRD) prevention, it is key to quantify joint effects of environmental exposures throughout the life-span as well as the mechanisms through which the exposures operate, which involve dynamic disease proces...

Research Terms

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Pinar Ayata

ADVANCED SCIENCE RESEARCH CENTER, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$510,365

FY 2026

Project Title

Neurodegenerative reprograming of microglia in Alzheimer’s disease

Grant Number:

5R01AG085404-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Genetic studies implicate microglia—the brain's primary innate immune cells—as major determinants for the risk of Alzheimer's Disease (AD). In murine AD models, microglia can assume phenotypes with protective or neurodegenerative functions, such as driving aberrant synapse loss. This propos...

Research Terms

<2-ketoglutarate><2-oxoglutarate><AD dementia><AD model><AD pathology><AD patients><AD risk><AD risk factor><AD therapy><AD treatment><APOE e4><APOE-ε4><APOEε4><Address><Aging><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's patient><Alzheimer's therapy><Alzheimers Dementia><Amyloid><Amyloid Substance><Amyloidosis><Automobile Driving><Behavior assessment><Biotech><Biotechnology><Brain><Brain Nervous System><Causality><Cell Body><Cells><Cellular Stress><Cellular Stress Response><Chromatin><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Core Facility><Creativeness><Darkness><Data><Development><Disease><Disorder><Disturbance in cognition><EIF-2 alpha><EIF-2alpha><EIF-2α><Elements><Encephalon><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Event><Exposure to><Future><Genes><Genetic><Genetic study><Grant><Heterochromatin><Heterogeneity><Histones><Hortega cell><Human><Image><Immune><Immunes><Impaired cognition><In Vitro><Initiation Factors><Knowledge><Late Onset Alzheimer Disease><Late onset AD><MT-bound tau><Macrophage><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Metabolic><Metabolic Pathway><Mice><Mice Mammals><Microglia><Mitochondria><Modeling><Modern Man><Molecular><Morphology><Murine><Mus><Mφ><Nerve Degeneration><Neuron Degeneration><Neurosciences><New York><Outcome><Pathologic><Pathology><Pathway interactions><Peptide Initiation Factors><Phagocytes><Phagocytic Cell><Phenotype><Phosphorylation><Play><Prevention><Primary Senile Degenerative Dementia><Process><Productivity><Protein Phosphorylation><Regulation><Research><Response to stimulus physiology><Risk><Risk Factors><Role><Science><Signal Pathway><Stimulus><Stress><Synapses><Synaptic><Tau forming aggregates><Tauopathies><Techniques><Testing><Therapeutic><Translation Initiation Factor><Translational Initiation Factor><abnormally aggregated tau protein><aggregation in tau><alpha Subunit Eukaryotic Initiation Factor 2><alpha ketoglutarate><alzheimer model><alzheimer risk><amebocyte><amyloid disease><amyloid pathology><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><behavioral assessment><biological adaptation to stress><causation><cell stress><chromatin remodeling><cofactor><cognitive assessment><cognitive dysfunction><cognitive loss><cognitive testing><creativity><data integration><demethylation><developmental><disease causation><driving><effective therapy><effective treatment><epigenetically><filamentous tau inclusion><gitter cell><histone methylation><imaging><in vivo><innovate><innovation><innovative><insight><insoluble aggregate><late onset alzheimer><life span><lifespan><mesoglia><microglial cell><microgliocyte><microtubule associated protein tau aggregation><microtubule associated protein tau deposit><microtubule bound tau><microtubule-bound tau><mitochondrial><mouse model><multiomics><multiple omics><murine model><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><neuropathologic tau><neuropathological tau><neuroprotection><neuroprotective><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-genetic><nongenetic><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><paired helical filament of tau><panomics><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><perivascular glial cell><prevent><preventing><primary degenerative dementia><programs><protein aggregate><protein aggregation><reactioncrisis><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><self-aggregate tau><senile dementia of the Alzheimer type><social role><stimulus/response><stress response><stressreaction><synapse><tau><tau PHF><tau Proteins><tau accumulation><tau aggregate><tau aggregation><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau fibrillation><tau fibrillization><tau filament><tau inclusion><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neurofibrillary tangle><tau neuropathology><tau oligomer><tau paired helical filament><tau pathology><tau pathophysiology><tau polymerization><tau protein accumulation><tau protein aggregation><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tau-tau interaction><tauopathic neurodegenerative disorder><tauopathy><technological innovation><therapeutic agent development><therapeutic development><tool><α-ketoglutarate><α-oxoglutarate><αKG><τ Proteins><τ aggregation>

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Shaolin Liu

UNIVERSITY OF GEORGIA, ATHENS, GA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$450,212

FY 2026

Project Title

APOE4 effects on glia-neuron interaction in the olfactory bulb

Grant Number:

5R01AG074216-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2022

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY: Understanding the causality between risk factors and early symptoms is crucial to early and differential diagnosis of Alzheimer’s disease (AD). Expression of the -4 allele of human apolipoprotein E (APOE4) gene, the strongest genetic risk factor for development of the episodic lat...

Research Terms

<6 year old><6 years of age><AD dementia><AD pathology><AD patients><AD risk><AD risk factor><APOE><APOE e4><APOE-ε4><APOEε4><Acceleration><Affect><Age><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's diagnosis><Alzheimer's disease diagnosis><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease risk><Alzheimer's pathology><Alzheimer's patient><Alzheimers Dementia><Amentia><Animal Model><Animal Models and Related Studies><Animals><Apo-E><ApoE protein><Apolipoprotein E><Astrocytes><Astrocytus><Astroglia><Atrophic><Atrophy><Behavioral><Blood - brain barrier anatomy><Blood Vessels><Blood-Brain Barrier><Brain><Brain Nervous System><Causality><Cell Communication and Signaling><Cell Signaling><Clinical><Clinical Research><Clinical Study><Cognitive><Complex><Connector Neuron><Data><Dementia><Dendrodendritic Synapse><Detection><Development><Differential Diagnosis><Disease><Disease Progression><Disorder><Dysfunction><Early Diagnosis><Electrophysiology><Electrophysiology (science)><Elements><Emotional><Encapsulated><Encephalon><Energy Expenditure><Energy Metabolism><Energy Supply><Ethics><Etiology><Extracellular Space><Functional disorder><Genes><Genetic><Genetic predisposing factor><Genotype><Glia><Glial Cells><Hemato-Encephalic Barrier><Human><Hyperactivity><Impairment><In Vitro><Incidence><Intercalary Neuron><Intercalated Neurons><Intercellular Space><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><K+ element><Knowledge><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Lipoproteins><Medical><Mice><Mice Mammals><Modern Man><Morphology><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Transmission><Neurobiology><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic Disorders><Neurological Disorders><Neuron Degeneration><Neurons><Neurophysiology / Electrophysiology><Non-neuronal cell><Nonneuronal cell><Odors><Olfaction><Olfactory Cortex><Olfactory Pathways><Olfactory system><Output><Pathogenesis><Pathology><Pathway interactions><Patients><Peripheral><Physiologic><Physiological><Physiopathology><Pilot Projects><Play><Population><Position><Positioning Attribute><Preventive><Primary Senile Degenerative Dementia><Process><Progressive Disease><Proteins><Psyche structure><QOL><Quality of life><Research><Risk Factors><Role><Signal Transduction><Signal Transduction Systems><Signaling><Smell><Smell Perception><Societies><Structure><Symptoms><Synapses><Synaptic><Synaptic Cleft><Synaptic Transmission><Testing><Upregulation><Vascular blood supply><Work><accurate diagnosis><age 6><age 6 years><ages><alzheimer risk><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><astrocytic glia><awake><behavior test><behavioral test><biological signal transduction><blood supply><bloodbrain barrier><causation><design><designing><developmental><disease causation><disease prognosis><disease prognostication><early detection><electrophysiological><ethical><genetic risk factor><improved><in vivo><inherited factor><late onset alzheimer><mental><mitral cell><model of animal><nerve cement><network dysfunction><neural degeneration><neurobiological><neurodegeneration><neurodegenerative><neurological degeneration><neurological disease><neuronal><neuronal degeneration><neuronal excitability><neurotransmitter uptake><new approaches><new technology><novel approaches><novel strategies><novel strategy><novel technologies><odor perception><olfactory bulb><olfactory bulb glomeruli><olfactory bulb glomerulus><olfactory circuitry><olfactory circuits><olfactory glomeruli><olfactory glomerulus><olfactory perception><pathophysiology><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><pilot study><postsynaptic><potassium ion><pre-clinical><preclinical><presynaptic><primary degenerative dementia><prodromal AD><prodromal Alzheimer's><prodromal Alzheimer's disease><prognosis biomarker><prognosis marker><response><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><signal processing><six year old><six years of age><social><social role><synapse><vascular><vascular supply>

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CONSTANTINE E FRANGAKIS

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$440,326

FY 2026

Project Title

Statistical methods to characterize patients who highly benefit across multifaceted clinical outcomes, from treatments in Alzheimers Disease and Related Dementias (ADRD)

Grant Number:

5R01AG083423-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Methods to characterize patients who highly beneﬁt on multiple clinical outcomes, from treatments in Alzheimer's disease and related dementias (ADRD), are necessary to treat patients effectively. Treatments may beneﬁt some patients on targeted outcomes, but harm some patients on othe...

Research Terms

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Joshua Goodyear Jackson

DREXEL UNIVERSITY, PHILADELPHIA, PA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$430,678

FY 2026

Project Title

Dysregulation of glutamate transporter-dependent neurovascular coupling in Alzheimer's disease

Grant Number:

5R01AG081929-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Dysregulation of glutamate transporter-dependent neurovascular coupling in Alzheimer’s disease Decreases in cerebral blood flow, glucose metabolism, and impairment of neurovascular coupling are associated with a number of neurodegenerative disease and cognitive decline, including Alzheimer’s disease...

Research Terms

<2-photon><AD dementia><AD model><Ablation><Abscission><Adventitial Cell><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimers Dementia><Astrocytes><Astrocytus><Astroglia><Attenuated><Basal Metabolism><Basal metabolic rate><Bioenergetics><Blood Vessels><Blood capillaries><Blood flow><Brain><Brain Nervous System><Brain region><Buffers><Cell Communication and Signaling><Cell Signaling><Cerebrovascular Circulation><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><D-Glucose><Degenerative Neurologic Disorders><Development><Dextrose><Diameter><Disease><Disorder><Disturbance in cognition><Elements><Encephalon><Endothelial Cells><Excision><Extirpation><Gene Expression><Genetic><Glucose><Glutamate Translocase><Glutamate Transport Glycoprotein><Glutamate Transporter><Glutamates><Glycogen><Goals><Impaired cognition><Impairment><Intracellular Communication and Signaling><Isoforms><Kinetics><Knowledge><L-Glutamate><Leiomyocyte><Link><Location><Measures><Mediating><Membrane><Metabolic><Methods><Microscopy><Mitochondria><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurons><Neurovascular dysfunction><Pathology><Pathway interactions><Pericapillary Cell><Pericytes><Perivascular Cell><Position><Positioning Attribute><Primary Senile Degenerative Dementia><Process><Protein Isoforms><Proteomics><Regulation><Removal><Role><Rouget Cells><Shapes><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Somatosensory Cortex><Stimulus><Surgical Removal><Symptoms><Synapses><Synaptic><Synaptic Cleft><Testing><Trees><Vascular Smooth Muscle><Vasodilatation><Vasodilation><Vasorelaxation><alzheimer model><arteriole><astrocytic glia><attenuate><attenuates><biological signal transduction><blood flow in brain><brain blood circulation><brain blood flow><brain metabolism><capillary><cell type><cerebral blood flow><cerebral circulation><cerebrocirculation><cerebrovascular blood flow><cognitive dysfunction><cognitive loss><constriction><cost><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><glucose metabolism><glutamatergic><human disease><imaging in vivo><in vivo><in vivo imaging><membrane structure><mitochondrial><mitochondrial dysfunction><mouse model><murine model><neural><neuro-vascular><neuro-vascular coupling><neuro-vascular unit><neurodegenerative illness><neuronal><neurovascular><neurovascular abnormality><neurovascular coupling><neurovascular dysregulation><neurovascular impairment><neurovascular pathology><neurovascular unit><neurovasculopathy><operation><operations><pathway><pharmacologic><primary degenerative dementia><resection><response><resting metabolic rate><senile dementia of the Alzheimer type><social role><somesthetic sensory cortex><synapse><transcriptomics><two-photon><vascular><vascular constriction><vasoconstriction>

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Ambika Bhagi

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$423,500

FY 2026

Project Title

Decoding and Reprogramming Redox Signal Transduction Pathways

Grant Number:

2R35GM138277-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2020

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Cells have evolved intricate enzymatic machineries that help them exist and survive redox stresses in their microenvironment. Enzymatic redox sensing, signaling, and response mechanisms are critical for a diverse set of physiological processes in all forms of life ranging from bacter...

Research Terms

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MARK A PETERSEN

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$408,885

FY 2026

Project Title

Overcoming the Inhibitory Neurovascular Niche in Preterm Infant Brain Injury

Grant Number:

5R01NS126498-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Preterm infants are at risk for central nervous system (CNS) hemorrhage which can disrupt cerebellar maturation and lead to permanent neurodevelopmental impairment. The molecular signals in the disrupted neurovascular niche that block cerebellar development are not known. Th...

Research Terms

<21+ years old><AD dementia><Acquired brain injury><Active Oxygen><Adult><Adult Human><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Animal Model><Animal Models and Related Studies><Attenuated><BBB disruption><BMP receptor><BMP type I receptor><BMPR-I><Binding><Binding Sites><Bleeding><Blocking Antibodies><Blood - brain barrier anatomy><Blood Clotting><Blood Coagulation Factor I><Blood Coagulation Factor One><Blood Factor One><Blood Plasma><Blood Proteins><Blood Vessels><Blood coagulation><Blood-Brain Barrier><Bone Morphogenetic Protein Gene><Bone Morphogenetic Proteins><Brain><Brain Injuries><Brain Nervous System><Brain hemorrhage><CD11b><CD18><CNS Nervous System><CR3A><Cell Body><Cell Communication and Signaling><Cell Maturation><Cell Signaling><Cells><Central Nervous System><Cerebellar hypoplasia><Cerebellum><Child Development Disorders><Cicatrix><Clinical Treatment Moab><Clotting><Coagulation><Coagulation Factor I><Coagulation Factor One><Coagulation Process><Combining Site><Congenital cerebellar hypoplasia><Cytoplasmic Granules><Data><Deposit><Deposition><Development><Developmental Disabilities><Disease><Disorder><Disseminated Sclerosis><Dysfunction><EYDF><Encephalon><Environment><Factor I><Factor One><Fibrin><Fibrinogen><Fibrinogen Receptors><Functional disorder><Generalized Growth><Genetic><Goals><Growth><Hemato-Encephalic Barrier><Hemorrhage><Hortega cell><Human><ITGAM><ITGAM gene><ITGB2><ITGB2 gene><Immune Cell Activation><Impairment><Inflammation><Inflammatory><Injections><Injury><Innate Immune Response><Integrins><Integrins Extracellular Matrix><Intracellular Communication and Signaling><KI mice><Knock-in Mouse><LCAMB><Link><Lipopolysaccharides><Long-term disability><MAC1A><MF17><MO1A><Macrophage><Microglia><Modeling><Modern Man><Molecular><Molecular Fingerprinting><Molecular Interaction><Molecular Profiling><Monoclonal Antibodies><Multiple Sclerosis><Mutant Strains Mice><Mutate><Myelin><Mφ><Natural regeneration><Neonatal><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Stem Cell><Neuraxis><Neurocyte><Neurodevelopmental Impairment><Neurologic Disorders><Neurological Disorders><Neuron Degeneration><Neurons><Organoids><Outcome><Oxidative Stress><Oxygen Radicals><Pathway interactions><Physiopathology><Plasma><Plasma Serum><Premature Infant><Primary Senile Degenerative Dementia><Pro-Oxidants><Progenitor Cells><Proteins><Reactive Oxygen Species><Reactive Site><Receptor Protein><Receptor Signaling><Regeneration><Reticuloendothelial System, Serum, Plasma><Risk><Role><Scars><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Testing><Therapeutic><Tissue Growth><Trauma><Traumatic injury><Treatment Efficacy><Work><activin A><adulthood><attenuate><attenuates><biological signal transduction><bleeding in brain><blood loss><blood-brain barrier disruption><bloodbrain barrier><bloodbrain barrier disruption><bone morphogenetic protein receptor type I><bone morphogenetic protein receptors><bone morphogenic protein><brain damage><brain injury in infants><brain-injured><clinical relevance><clinically relevant><defined contribution><determine efficacy><developmental><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><erythroid differentiation factor><erythroid differentiation protein><evaluate efficacy><examine efficacy><gitter cell><granule><hemorrhagic stroke><hiPSC><homo-activin A><human disease><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSCs><immune activation><improved><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infant brain injury><infants born premature><infants born prematurely><inhibitor><injuries><insular sclerosis><intervention efficacy><knockin mice><mAbs><mesoglia><microglial cell><microgliocyte><model of animal><molecular profile><molecular signature><monoclonal Abs><mouse mutant><neonatal mice><nerve stem cell><nervous system development><neural degeneration><neural inflammation><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neuro-vascular><neurodegeneration><neurodegenerative><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuroinflammation><neuroinflammatory><neurological degeneration><neurological disease><neuron progenitors><neuronal><neuronal degeneration><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><neurovascular><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><pathophysiology><pathway><perivascular glial cell><pharmacologic><premature baby><premature infant human><preservation><preterm baby><preterm infant><preterm infant human><prevent><preventing><primary degenerative dementia><progenitor and neural stem cells><progenitor cell fate><progenitor cell pool><progenitor cell population><progenitor cell proliferation><progenitor fate><progenitor pool><progenitor population><progenitor proliferation><re-myelinate><re-myelination><receptor><regenerate><remyelinate><remyelination><repair><repaired><senile dementia of the Alzheimer type><social role><stem and progenitor cell fate><stem and progenitor cell population><stem and progenitor cell proliferation><stem cell fate><stem cell pool><stem cell population><stem cell proliferation><stem cells><systemic inflammation><systemic inflammatory response><therapeutic efficacy><therapy efficacy><transcriptomics><vascular>

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Shantanu P Jadhav

BRANDEIS UNIVERSITY, WALTHAM, MA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$404,159

FY 2026

Project Title

Role of physiological patterns in hippocampal-prefrontal interactions

Grant Number:

5R01MH112661-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2017

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/ Abstract The hippocampus and medial prefrontal cortex (PFC) are both critical for learning and memory-guided behavior. Coordination of neural activity between these regions is necessary for memory and cognitive processes, however, the nature of these interactions and their roles are...

Research Terms

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Stephanie Cherqui

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$395,000

FY 2026

Project Title

Understanding the mechanism of rescue of Alzheimers disease by hematopoietic stem cell transplantation

Grant Number:

5R01AG086443-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Alzheimer’s Disease (AD) is the most prevalent cause of dementia and the most common age-related neurodegenerative disorder characterized by the progressive degradation of neurons, inflammation, decline in memory and behavior, and the accumulation of β-amyloid (Aβ) plaque in the brai...

Research Terms

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Kevin Lin

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$380,371

FY 2026

Project Title

Decoding cellular history in longitudinally inaccessible tissues

Grant Number:

1R35GM162089-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

The overarching objective of this project is to develop computational methods to infer cellular history from single-cell sequencing data, enabling insights into disease progression in tissues that are not longitudinally accessible, such as the brain to study Alzheimer’s disease or the heart to study...

Research Terms

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Juhee Haam

LOUISIANA STATE UNIV A&M COL BATON ROUGE, BATON ROUGE, LA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$369,056

FY 2026

Project Title

Role of the Entorhinal Cortical Delta Oscillations in Systems Consolidation

Grant Number:

5R01MH140001-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary / Abstract Memory consolidation, a crucial step in memory formation that creates long-lasting engrams in the neocortex using labile memory created during waking, is severely impaired in Alzheimer’s disease. Memory consolidation occurs via two levels: Cellular consolidation, which sto...

Research Terms

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Stephanie Anne-Carine Debette

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$338,964

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S2

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Carole Dufouil

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$338,964

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S2

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Mohammad Arfan Ikram

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$338,964

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S2

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Claudia L Satizabal

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$338,964

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S2

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Sudha Seshadri

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$338,964

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S2

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Astrid M Suchy-Dicey

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$338,964

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S2

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Michael R Lawson

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$286,729

FY 2026

Project Title

Defining the dynamics of eukaryotic translation and mRNA decay

Grant Number:

1R35GM162831-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary / Abstract Protein synthesis, also known a translation, is a highly regulated process with deep significance to public health. Dysregulation of translation is a major driver of diseases such as cancer, and mutations that prematurely halt translation cause 11% of all heritable human d...

Research Terms

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Stephanie Anne-Carine Debette

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$267,160

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S3

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Carole Dufouil

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$267,160

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S3

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Mohammad Arfan Ikram

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$267,160

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S3

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Claudia L Satizabal

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$267,160

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S3

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sudha Seshadri

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$267,160

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S3

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Astrid M Suchy-Dicey

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$267,160

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S3

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Esther Marian Blessing

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 56/100

Likely hiring

Very recent

Active award

$239,898

FY 2026

Project Title

Sleep and Temperature Disturbance as risk factors for Alzheimer's Disease in Down Syndrome: a Longitudinal Study

Grant Number:

4R01AG080769-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Abstract Down syndrome (DS), the most frequent form of intellectual disability of genetic origin, involves a >95% cumulative risk of Alzheimer’s Disease (AD) by the seventh decade. Further, AD is now the most common cause of death in this population as life expectancy in DS individua...

Research Terms

<21+ years old><A β-42><A β42><A-beta 42><A-beta42><AD biological marker><AD biomarker><AD dementia><AD pathology><AD related biomarker><AD risk><AD risk factor><APOE e4><APOE-ε4><APOEε4><Abeta-42><Abeta42><Acceleration><Active Follow-up><Adult><Adult Human><Affect><Age><Age of Onset><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's pathology><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><Ammon Horn><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-42><Amyloid beta-Protein><Amyloid beta42><Amyloid β><Amyloid β-42><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β42><Amyloidβ-42><Amyloidβ42><Apnea><Aβ><Aβ-42><Aβ42><Biological Markers><Blood><Blood Plasma><Blood Reticuloendothelial System><Body Temperature><Body Temperature Regulation><Body Thermoregulation><Brain><Brain Nervous System><Brain region><Cause of Death><Cerebrospinal Fluid><Circadian Dysregulation><Circadian Rhythms><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Cornu Ammonis><Data><Data Collection><Delta Wave><Delta Wave sleep><Disease Marker><Disease Progression><Disturbance in cognition><Down Syndrome><Dysfunction><EOAD><Early Onset Alzheimer Disease><Encephalon><Evaluation><Functional disorder><Genetic><Genetic Diseases><Goals><Heterogeneity><High Prevalence><Hippocampus><Home><Hour><Impaired cognition><Individual><Individuals with down syndrome><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Langdon Down syndrome><Lead><Life Expectancy><Light><Literature><Longitudinal Studies><Longitudinal Surveys><Longitudinal observational study><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Measurement><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Modeling><Mongolism><NMR Imaging><NMR Tomography><Nerve Degeneration><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Nyctohemeral Rhythm><Obstructive Sleep Apnea><Onset of illness><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Pathology><Pb element><Persons><Photoradiation><Physiologic Thermoregulation><Physiopathology><Plasma><Plasma Serum><Polysomnography><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Rad.-PET><Research><Reticuloendothelial System, Serum, Plasma><Risk Factors><Severities><Sleep><Sleep Monitoring><Sleep disturbances><Slow-Wave Sleep><Somnography><Structure><Study models><Syndrome, Sleep Apnea, Obstructive><Tauopathies><Telemetries><Telemetry><Temperature><Testing><Thermoregulation><Thick><Thickness><Trisomy 21><Twenty-Four Hour Rhythm><Work><Wrist><Zeugmatography><a beta peptide><aberrant sleep><abeta><actigraph><actigraphy><active followup><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged><ages><alzheimer risk><amyloid beta><amyloid-b protein><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><autosomal dominant AD><autosomal dominant Alzheimer's disease><beta amyloid fibril><bio-markers><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><cerebral spinal fluid><chromosome 21 trisomy><chromosome 21 trisomy syndrome><circadian><circadian abnormality><circadian disruption><circadian disturbance><circadian dysfunction><circadian impairment><circadian process><circadian rhythmicity><cognitive assessment><cognitive change><cognitive dysfunction><cognitive loss><cognitive performance><cognitive testing><cohort><congenital acromicria syndrome><cumulative risk><daily biorhythm><disease onset><disorder onset><disrupted sleep><disturbed sleep><down syndrome individuals><down syndrome patients><early onset AD><early onset Alzheimer's><follow up><follow-up><followed up><followup><genetic condition><genetic disorder><heavy metal Pb><heavy metal lead><high risk><hippocampal><homes><impaired sleep><indexing><intellectual and developmental disability><irregular sleep><later in life><later life><life-time risk><lifetime risk><limited intellectual functioning><long term observational study><long-term study><longitudinal outcome studies><longitudinal research study><malleable risk><microtubule bound tau><microtubule-bound tau><modifiable risk><morbus Down><neural degeneration><neural imaging><neuro-imaging><neurodegeneration><neurodegenerative><neurofilament><neuroimaging><neurological degeneration><neurological imaging><neuronal degeneration><neuropathologic tau><neuropathological tau><novel><older adult><older adulthood><p-tau><p-τ><pathophysiology><patients with down syndrome><people with down syndrome><phospho-tau><phospho-τ><phosphorylated tau><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><post-translational modification of tau><posttranslational modification of tau><pre-clinical><preclinical><primary degenerative dementia><progression biomarker><progression marker><pseudohypertrophic progressive muscular dystrophy><rate of change><recruit><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><screening><screenings><senile dementia of the Alzheimer type><sex><sleep amount><sleep disruption><sleep duration><sleep dysregulation><sleep episode><sleep interval><sleep length><sleep measurement><sleep period><sleep polysomnography><sleep quantity><sleep time><sleep/wake disruption><sleep/wake disturbance><soluble amyloid precursor protein><spinal fluid><symptomatology><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau phosphorylation><tau posttranslational modification><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><telemetric><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><trisomy 21 syndrome><uptake><τ Proteins><τ phosphorylation>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Juan Fortea

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 56/100

Likely hiring

Very recent

Active award

$239,898

FY 2026

Project Title

Sleep and Temperature Disturbance as risk factors for Alzheimer's Disease in Down Syndrome: a Longitudinal Study

Grant Number:

4R01AG080769-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Abstract Down syndrome (DS), the most frequent form of intellectual disability of genetic origin, involves a >95% cumulative risk of Alzheimer’s Disease (AD) by the seventh decade. Further, AD is now the most common cause of death in this population as life expectancy in DS individua...

Research Terms

<21+ years old><A β-42><A β42><A-beta 42><A-beta42><AD biological marker><AD biomarker><AD dementia><AD pathology><AD related biomarker><AD risk><AD risk factor><APOE e4><APOE-ε4><APOEε4><Abeta-42><Abeta42><Acceleration><Active Follow-up><Adult><Adult Human><Affect><Age><Age of Onset><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's pathology><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><Ammon Horn><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-42><Amyloid beta-Protein><Amyloid beta42><Amyloid β><Amyloid β-42><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β42><Amyloidβ-42><Amyloidβ42><Apnea><Aβ><Aβ-42><Aβ42><Biological Markers><Blood><Blood Plasma><Blood Reticuloendothelial System><Body Temperature><Body Temperature Regulation><Body Thermoregulation><Brain><Brain Nervous System><Brain region><Cause of Death><Cerebrospinal Fluid><Circadian Dysregulation><Circadian Rhythms><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Cornu Ammonis><Data><Data Collection><Delta Wave><Delta Wave sleep><Disease Marker><Disease Progression><Disturbance in cognition><Down Syndrome><Dysfunction><EOAD><Early Onset Alzheimer Disease><Encephalon><Evaluation><Functional disorder><Genetic><Genetic Diseases><Goals><Heterogeneity><High Prevalence><Hippocampus><Home><Hour><Impaired cognition><Individual><Individuals with down syndrome><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Langdon Down syndrome><Lead><Life Expectancy><Light><Literature><Longitudinal Studies><Longitudinal Surveys><Longitudinal observational study><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Measurement><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Modeling><Mongolism><NMR Imaging><NMR Tomography><Nerve Degeneration><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Nyctohemeral Rhythm><Obstructive Sleep Apnea><Onset of illness><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Pathology><Pb element><Persons><Photoradiation><Physiologic Thermoregulation><Physiopathology><Plasma><Plasma Serum><Polysomnography><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Rad.-PET><Research><Reticuloendothelial System, Serum, Plasma><Risk Factors><Severities><Sleep><Sleep Monitoring><Sleep disturbances><Slow-Wave Sleep><Somnography><Structure><Study models><Syndrome, Sleep Apnea, Obstructive><Tauopathies><Telemetries><Telemetry><Temperature><Testing><Thermoregulation><Thick><Thickness><Trisomy 21><Twenty-Four Hour Rhythm><Work><Wrist><Zeugmatography><a beta peptide><aberrant sleep><abeta><actigraph><actigraphy><active followup><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged><ages><alzheimer risk><amyloid beta><amyloid-b protein><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><autosomal dominant AD><autosomal dominant Alzheimer's disease><beta amyloid fibril><bio-markers><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><cerebral spinal fluid><chromosome 21 trisomy><chromosome 21 trisomy syndrome><circadian><circadian abnormality><circadian disruption><circadian disturbance><circadian dysfunction><circadian impairment><circadian process><circadian rhythmicity><cognitive assessment><cognitive change><cognitive dysfunction><cognitive loss><cognitive performance><cognitive testing><cohort><congenital acromicria syndrome><cumulative risk><daily biorhythm><disease onset><disorder onset><disrupted sleep><disturbed sleep><down syndrome individuals><down syndrome patients><early onset AD><early onset Alzheimer's><follow up><follow-up><followed up><followup><genetic condition><genetic disorder><heavy metal Pb><heavy metal lead><high risk><hippocampal><homes><impaired sleep><indexing><intellectual and developmental disability><irregular sleep><later in life><later life><life-time risk><lifetime risk><limited intellectual functioning><long term observational study><long-term study><longitudinal outcome studies><longitudinal research study><malleable risk><microtubule bound tau><microtubule-bound tau><modifiable risk><morbus Down><neural degeneration><neural imaging><neuro-imaging><neurodegeneration><neurodegenerative><neurofilament><neuroimaging><neurological degeneration><neurological imaging><neuronal degeneration><neuropathologic tau><neuropathological tau><novel><older adult><older adulthood><p-tau><p-τ><pathophysiology><patients with down syndrome><people with down syndrome><phospho-tau><phospho-τ><phosphorylated tau><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><post-translational modification of tau><posttranslational modification of tau><pre-clinical><preclinical><primary degenerative dementia><progression biomarker><progression marker><pseudohypertrophic progressive muscular dystrophy><rate of change><recruit><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><screening><screenings><senile dementia of the Alzheimer type><sex><sleep amount><sleep disruption><sleep duration><sleep dysregulation><sleep episode><sleep interval><sleep length><sleep measurement><sleep period><sleep polysomnography><sleep quantity><sleep time><sleep/wake disruption><sleep/wake disturbance><soluble amyloid precursor protein><spinal fluid><symptomatology><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau phosphorylation><tau posttranslational modification><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><telemetric><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><trisomy 21 syndrome><uptake><τ Proteins><τ phosphorylation>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kristen Knutson

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 56/100

Likely hiring

Very recent

Active award

$101,947

FY 2026

Project Title

The Proteomic Signature of Sleep and its implication for Alzheimer's Disease

Grant Number:

3R01AG089354-01A1S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Alzheimer's Disease (AD) is characterized by progressive cognitive decline leading to mortality and is a leading cause of death among older adults. The disease involves the formation of plaques and tangles in the brain, which hinder cognitive functioning. Alzheimer's Disease is also ...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD and related dementia><AD biological marker><AD biomarker><AD dementia><AD pathway><AD related biomarker><AD related dementia><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><ADRD><Active Follow-up><Address><Adult><Adult Human><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's biomarker><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related biomarker><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's related biomarker><Alzheimer's related pathways><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Architecture><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Brain><Brain Nervous System><Brazil><CNS lymphatic system><Cause of Death><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Data><Dementia><Development><Dimensions><Disease><Disease Progression><Disorder><Disturbance in cognition><EEG><Electroencephalogram><Electroencephalography><Encephalon><Engineering / Architecture><Evaluation><Experimental Designs><Genes><Goals><Graph><Heart><Hour><Human><IFN><Impaired cognition><Individual><Interferons><Knowledge><Link><Long-term Follow-up><Longitudinal Studies><Longitudinal Surveys><MT-bound tau><Maintenance><Maps><Measures><Mediating><Memory><Modern Man><Molecular><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocognition><Neurocognitive><Neurocyte><Neurofibrillary Tangles><Neuron Degeneration><Neurons><Participant><Pathway interactions><Performance><Phenotype><Play><Polysomnography><Predisposing Factor><Primary Senile Degenerative Dementia><Process><Proteins><Proteomics><Protocol><Protocols documentation><Research><Risk><Risk Factors><Role><Sampling><Sleep><Sleep Architecture><Sleep Monitoring><Sleep disturbances><Somnography><System><Testing><Time><aberrant sleep><above age 65><active followup><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><alzheimer risk><bio-markers><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><brain health><brain lymph system><brain lymphatic system><cognitive assessment><cognitive change><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive testing><design><designing><developmental><disability><disrupted sleep><disturbed sleep><endophenotype><experiment><experimental research><experimental study><experiments><follow up><follow-up><followed up><followup><glia lymphatic circuit><glia-lymphatic system><glial lymphatic system><glialymphatic circuit><glialymphatic network><glialymphatic pathway><glialymphatic system><glymphatic clearance pathway><glymphatic pathway><glymphatic system><glymphatic-lymphatic system><glymphatics><human old age (65+)><impaired sleep><improved><inter-individual variability><inter-individual variation><irregular sleep><knowledge graph><long-term followup><long-term study><longitudinal outcome studies><longitudinal research study><mechanisms in AD><mechanisms in Alzheimer's disease><microtubule bound tau><microtubule-bound tau><molecular biomarker><molecular marker><mortality><neural degeneration><neurocognitive test><neurodegeneration><neurodegenerative><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurological degeneration><neuronal><neuronal degeneration><novel><older adult><older adulthood><over 65 years><paravascular system><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><primary degenerative dementia><protein biomarkers><protein markers><proteomic signature><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sleep disruption><sleep dysregulation><sleep measurement><sleep polysomnography><sleep/wake disruption><sleep/wake disturbance><social role><tangle><tau><tau Proteins><tau factor><τ Proteins><≥65 years>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Alexandre C Pereira

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 56/100

Likely hiring

Very recent

Active award

$101,947

FY 2026

Project Title

The Proteomic Signature of Sleep and its implication for Alzheimer's Disease

Grant Number:

3R01AG089354-01A1S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Alzheimer's Disease (AD) is characterized by progressive cognitive decline leading to mortality and is a leading cause of death among older adults. The disease involves the formation of plaques and tangles in the brain, which hinder cognitive functioning. Alzheimer's Disease is also ...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD and related dementia><AD biological marker><AD biomarker><AD dementia><AD pathway><AD related biomarker><AD related dementia><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><ADRD><Active Follow-up><Address><Adult><Adult Human><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's biomarker><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related biomarker><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's related biomarker><Alzheimer's related pathways><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Architecture><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Brain><Brain Nervous System><Brazil><CNS lymphatic system><Cause of Death><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Data><Dementia><Development><Dimensions><Disease><Disease Progression><Disorder><Disturbance in cognition><EEG><Electroencephalogram><Electroencephalography><Encephalon><Engineering / Architecture><Evaluation><Experimental Designs><Genes><Goals><Graph><Heart><Hour><Human><IFN><Impaired cognition><Individual><Interferons><Knowledge><Link><Long-term Follow-up><Longitudinal Studies><Longitudinal Surveys><MT-bound tau><Maintenance><Maps><Measures><Mediating><Memory><Modern Man><Molecular><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocognition><Neurocognitive><Neurocyte><Neurofibrillary Tangles><Neuron Degeneration><Neurons><Participant><Pathway interactions><Performance><Phenotype><Play><Polysomnography><Predisposing Factor><Primary Senile Degenerative Dementia><Process><Proteins><Proteomics><Protocol><Protocols documentation><Research><Risk><Risk Factors><Role><Sampling><Sleep><Sleep Architecture><Sleep Monitoring><Sleep disturbances><Somnography><System><Testing><Time><aberrant sleep><above age 65><active followup><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><alzheimer risk><bio-markers><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><brain health><brain lymph system><brain lymphatic system><cognitive assessment><cognitive change><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive testing><design><designing><developmental><disability><disrupted sleep><disturbed sleep><endophenotype><experiment><experimental research><experimental study><experiments><follow up><follow-up><followed up><followup><glia lymphatic circuit><glia-lymphatic system><glial lymphatic system><glialymphatic circuit><glialymphatic network><glialymphatic pathway><glialymphatic system><glymphatic clearance pathway><glymphatic pathway><glymphatic system><glymphatic-lymphatic system><glymphatics><human old age (65+)><impaired sleep><improved><inter-individual variability><inter-individual variation><irregular sleep><knowledge graph><long-term followup><long-term study><longitudinal outcome studies><longitudinal research study><mechanisms in AD><mechanisms in Alzheimer's disease><microtubule bound tau><microtubule-bound tau><molecular biomarker><molecular marker><mortality><neural degeneration><neurocognitive test><neurodegeneration><neurodegenerative><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurological degeneration><neuronal><neuronal degeneration><novel><older adult><older adulthood><over 65 years><paravascular system><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><primary degenerative dementia><protein biomarkers><protein markers><proteomic signature><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sleep disruption><sleep dysregulation><sleep measurement><sleep polysomnography><sleep/wake disruption><sleep/wake disturbance><social role><tangle><tau><tau Proteins><tau factor><τ Proteins><≥65 years>

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Carlos Cruchaga

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 56/100

Likely hiring

Recent

Active award

Team-scale grant

$101,153

FY 2026

Project Title

CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"

Grant Number:

3U01AG084514-01A1S1

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Genetic studies in the context of Alzheimer Disease (AD) are significantly biased by information coming from the same homogeneous population: Non-Hispanics Whites (NHW). The ADSP Follow-Up Study (FUS) long term goals include to fully reveal the genetic architecture of AD in multiple ethnic groups an...

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Jorge Jesus Llibre-Guerra

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 56/100

Likely hiring

Recent

Active award

Team-scale grant

$101,153

FY 2026

Project Title

CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"

Grant Number:

3U01AG084514-01A1S1

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Genetic studies in the context of Alzheimer Disease (AD) are significantly biased by information coming from the same homogeneous population: Non-Hispanics Whites (NHW). The ADSP Follow-Up Study (FUS) long term goals include to fully reveal the genetic architecture of AD in multiple ethnic groups an...

Research Terms

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Gary Allen Rosenberg

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Good lead · 56/100

Likely hiring

Recent

Active award

Team-scale grant

$96,505

FY 2026

Project Title

New Mexico Alzheimer's Disease Research Center

Grant Number:

3P30AG086404-02S1

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

5/1/2024

End Date:

4/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY The New Mexico Brain Bank, housing approximately 280 archived brains from New Mexicans, is a uniquely valuable resource for the New Mexico Alzheimer’s Disease Research Center (NM ADRC) and the national ADRC network. Relocation from the Office of the Medical Investigator to secure spa...

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Sue Tilton Griffin

UNIV OF ARKANSAS FOR MED SCIS, LITTLE ROCK, AR

Good lead · 52/100

Likely hiring

Solid budget

Active award

$470,331

FY 2026

Project Title

Neuroinflammation, Protein Aggregates, ApoE4 Drug Targeting, and Autophagy Rescue

Grant Number:

5R01AG084472-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

We established the pluripotent interleukin-1β (IL-1 β) cytokine as a significant player in the pathogenesis of Alzheimer’s disease as it sets in motion a self-amplifying positive-feedback cycle in which neuronal stress induces synthesis of the neuron's acute phase protein β APP and release of its fr...

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Heather Ferris

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$457,526

FY 2026

Project Title

Mevalonate Pathway Regulation of Astrocyte ApoE

Grant Number:

5R01AG080773-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract The ApoE 4 isoform is the strongest genetic link to Alzheimer’s disease for unclear reasons. ApoE is a lipid carrying protein. Both the content of the ApoE particles and their release from astrocytes varies by ApoE isoform. We have found that the mevalonate pathway can regulate both the rel...

Research Terms

<(TNF)-α><AD dementia><AD model><AD pathology><AD risk><AD risk factor><AD therapy><AD treatment><APOE><APOE e3><APOE e4><APOE-ε4><APOEε4><Abeta synthesis><Address><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's precursor protein><Alzheimer's therapy><Alzheimers Dementia><Amyloid (Aβ) plaques><Amyloid A4 Protein Precursor><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Protein Precursor><Amyloid beta-Protein><Amyloid beta-Protein Precursor><Amyloid β><Amyloid β production><Amyloid β synthesis><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β-Protein Precursor><Anticholesteremic Agents><Anticholesteremic Drugs><Anticholesteremics><Apo-E><ApoE protein><Apolipoprotein E><Astrocytes><Astrocytus><Astroglia><Automobile Driving><Aβ><Aβ production><Aβ synthesis><Behavior><Brain><Brain Nervous System><C1 q><C1q><Cachectin><Cell Death><Cell Function><Cell Membrane Lipid Rafts><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Chemicals><Cholesterol><Cholesterol Homeostasis><Cholesterol Inhibitors><Cholesterol Synthesis Inhibition><Cholesterol-Lowering Drugs><Cholesterol-Lowering agents><Complement 1q><Complement C1q><Confocal Microscopy><Data><Drops><ELISA><Encephalon><Enzyme-Linked Immunosorbent Assay><Ethidium><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Future><Genetic><Genetic Suppression><Genetic predisposing factor><Genotype><Human><IL-1 alpha><IL-1-a><IL-1A><IL-1alpha><IL-1α><IL1-Alpha><IL1-α><IL1A Protein><IL1F1><Individual><Interleukin 1alpha><Interleukin-1 alpha><Isoforms><KI mice><Knock-in Mouse><Knock-out><Knockout><Late Onset Alzheimer Disease><Late onset AD><Link><Lipids><Macrophage-Derived TNF><Measures><Mediating><Membrane Biology><Membrane Microdomains><Mice><Mice Mammals><Modern Man><Monocyte-Derived TNF><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neuritic Plaques><Neurocyte><Neurons><Pathway interactions><Pharmacology><Phenotype><Post-Translational Isoprenylation><Posttranslational Isoprenylation><Preinterleukin 1 Alpha><Prevention><Primary Senile Degenerative Dementia><Production><Protein Isoforms><Protein Isoprenylation><Protein Prenylation><Protein Secretion><Protein-Free Media><Proteins><Regulation><Risk><Role><Saturated Fatty Acids><Senile Plaques><Serum-Free Culture Media><Serum-Free Media><Sphingolipid Microdomains><Sphingolipid-Cholesterol Rafts><Subcellular Process><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Techniques><Testing><Therapeutic><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><a beta peptide><abeta><abeta production><alzheimer model><alzheimer risk><amyloid beta><amyloid beta plaque><amyloid beta production><amyloid beta synthesis><amyloid precursor protein><amyloid-b plaque><amyloid-b protein><anti-cholesterol agents><anti-cholesterol drugs><antihypercholesterolemic agent><apo E-2><apo E-3><apo E-4><apo E2><apo E3><apo E4><apo epsilon4><apoE epsilon 4><apoE-2><apoE-3><apoE-4><apoE3><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-2><apolipoprotein E-3><apolipoprotein E-4><apolipoprotein E2><apolipoprotein E3><apolipoprotein E4><arm><astrocytic glia><aβ plaques><beta amyloid fibril><chemoproteomics><cholesterol metabolism><conditional knock-out><conditional knockout><cored plaque><diffuse plaque><driving><enzyme linked immunoassay><experiment><experimental research><experimental study><experiments><flow cytophotometry><genetic risk factor><homidium><improved><in vivo><inherited factor><inhibitor><knockin mice><late onset alzheimer><lipid raft><mevalonate><mouse model><murine model><necrocytosis><nerve cell death><nerve cell loss><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal loss><neuronal survival><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><particle><pathway><prenylation><preservation><prevent><preventing><primary degenerative dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><shRNA><short hairpin RNA><social role><soluble amyloid precursor protein><superresolution imaging><tool>

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Paul Lieberman Greer

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$445,130

FY 2026

Project Title

Elucidation of the mechanisms by which Ms4a genes regulate neurodegeneration in Alzheimer's Disease and related disorders

Grant Number:

1R01AG089801-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract Current therapeutic interventions for treating neurodegenerative disorders, including Alzheimer’s Disease (AD), frontotemporal dementia (FTD), multiple sclerosis (MS), and Amyotrophic lateral sclerosis (ALS), are highly limited in both number and efficacy, suggesting novel approaches are ne...

Research Terms

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Mei Cheng Wang

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 52/100

Likely hiring

Solid budget

Active award

$442,688

FY 2026

Project Title

Statistical methods for analyzing risk of Alzheimer's Disease and biomarker measurements

Grant Number:

5R01AG088637-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY The objective of this project is to develop and apply statistical methods to improve scientiﬁc inferences in Alzheimer's disease (AD) research when cross-sectional or longitudinal study designs are employed. The proposed approaches are largely motivated by three large-scale studies (...

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RUI-MING LIU

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Good lead · 52/100

Likely hiring

Solid budget

Active award

$441,440

FY 2026

Project Title

Sex-dependent synergy between O3 exposure, APOE4 e4 genotype, and aging in the onset of Alzheimer's disease

Grant Number:

5R01AG077395-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

The etiology for late-onset Alzheimer’s disease (LOAD), which accounts for >95% of AD cases, is unknown. Aging is the greatest risk factor for LOAD, whereas APOE4 is believed to be a major genetic risk factor in acquiring LOAD, with female APOE4 carriers at the greatest risk. Yet, not all of APOE...

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XUELIN LOU

MEDICAL COLLEGE OF WISCONSIN, MILWAUKEE, WI

Good lead · 52/100

Likely hiring

Solid budget

Active award

$390,000

FY 2026

Project Title

Understanding the degeneration of axon and nerve terminals in Alzheimer's disease and related dementia brain

Grant Number:

5R01AG079257-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY A remarkable brain attribute is a lifelong ability to store and retrieve information for learning and memory. Alzheimer's disease (AD) destroys this function and generates enormous personal, familial, and societal impacts. This situation is further compounded by the lack of disease-m...

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ERIN G REED

NORTHEAST OHIO MEDICAL UNIVERSITY, ROOTSTOWN, OH

Good lead · 52/100

Likely hiring

Solid budget

Active award

$390,000

FY 2026

Project Title

The developmental effects of sex chromosomes and hormones specify microglial inflammation in Alzheimer's diseaes

Grant Number:

5R01AG075897-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Although women are known to be disproportionally affected by Alzheimer’s disease (AD), the underlying biology for this difference is unresolved. Our long-term goal is to help develop therapies that can be used in the prevention and treatment of Alzheimer’s disease and other...

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Christopher McKennan

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$378,325

FY 2026

Project Title

Statistical methods for population-level cell-type-specific analyses of tissue omics data for Alzheimer's disease

Grant Number:

5R01AG080590-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Alzheimer's disease (AD) accounts for 60-80% of dementia cases and causes progressive neurodegeneration that ultimately leads to death. While the number of US people with late-onset AD is expected to reach 13.8 million by 2050, its prevention and treatment remain only modest...

Research Terms

<0-11 years old><AD dementia><AD pathway><AD-associated pathways><AD-related pathways><AD-specific pathways><Acceleration><Address><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Amentia><Behavior><Biology><Body Tissues><Brain><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Signaling><Cells><Cessation of life><Child><Child Youth><Children (0-21)><Clinical Treatment><Communities><Complement><Complement Proteins><Complex><Computational algorithm><Computer software><Computing Methodologies><DNA><DNA Methylation><Data><Data Analyses><Data Analysis><Data Set><Death><Dementia><Deoxyribonucleic Acid><Dependence><Development><Dysfunction><Encephalon><Functional disorder><Future><Gene Expression><Genes><Genotype><Goals><Human><Intracellular Communication and Signaling><Knowledge><Late Onset Alzheimer Disease><Late onset AD><Learning><Masks><Mediation><Medicine><Methods><Methylation><Modern Man><Multiomic Data><National Institute of Aging><National Institute on Aging><Negotiating><Negotiation><Non-Polyadenylated RNA><Parents><Pathogenesis><Pathogenicity><Pathway interactions><Persons><Physiopathology><Population><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Probabilistic Models><Probability Models><Problem Solving><Proteins><Proteome><Proteomics><RNA><RNA Gene Products><Research><Resolution><Ribonucleic Acid><Role><Sample Size><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Site><Software><Solid><Specificity><Statistical Methods><Statistical Models><Techniques><Technology><Testing><Tissue Sample><Tissues><Variant><Variation><accelerated aging><accelerated biological age><accelerated biological aging><age acceleration><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging population><biological signal transduction><brain cell><brain tissue><cell type><clinical intervention><clinical therapy><cohort><complementation><computational methodology><computational methods><computer algorithm><computer based method><computer methods><computing method><cost><cost efficient><data interpretation><developmental><epigenome><genome scale><genome-wide><genomewide><global gene expression><global transcription profile><high dimensionality><improved><innovate><innovation><innovative><insight><kids><late onset alzheimer><mechanisms in AD><mechanisms in Alzheimer's disease><multiomics><multiple omic data><multiple omics><novel><panomics><parent><pathophysiology><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><population aging><primary degenerative dementia><progressive neurodegeneration><resolutions><sNuc-Seq><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell technology><single cell transcriptomic profiling><single nucleus RNA-sequencing><single nucleus seq><single-cell RNA sequencing><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><statistic methods><statistical linear mixed models><statistical linear models><statistics><tool><transcriptome><treatment strategy><trial regimen><trial treatment><youngster>

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Jiebiao Wang

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$378,325

FY 2026

Project Title

Statistical methods for population-level cell-type-specific analyses of tissue omics data for Alzheimer's disease

Grant Number:

5R01AG080590-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Alzheimer's disease (AD) accounts for 60-80% of dementia cases and causes progressive neurodegeneration that ultimately leads to death. While the number of US people with late-onset AD is expected to reach 13.8 million by 2050, its prevention and treatment remain only modest...

Research Terms

<0-11 years old><AD dementia><AD pathway><AD-associated pathways><AD-related pathways><AD-specific pathways><Acceleration><Address><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Amentia><Behavior><Biology><Body Tissues><Brain><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Signaling><Cells><Cessation of life><Child><Child Youth><Children (0-21)><Clinical Treatment><Communities><Complement><Complement Proteins><Complex><Computational algorithm><Computer software><Computing Methodologies><DNA><DNA Methylation><Data><Data Analyses><Data Analysis><Data Set><Death><Dementia><Deoxyribonucleic Acid><Dependence><Development><Dysfunction><Encephalon><Functional disorder><Future><Gene Expression><Genes><Genotype><Goals><Human><Intracellular Communication and Signaling><Knowledge><Late Onset Alzheimer Disease><Late onset AD><Learning><Masks><Mediation><Medicine><Methods><Methylation><Modern Man><Multiomic Data><National Institute of Aging><National Institute on Aging><Negotiating><Negotiation><Non-Polyadenylated RNA><Parents><Pathogenesis><Pathogenicity><Pathway interactions><Persons><Physiopathology><Population><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Probabilistic Models><Probability Models><Problem Solving><Proteins><Proteome><Proteomics><RNA><RNA Gene Products><Research><Resolution><Ribonucleic Acid><Role><Sample Size><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Site><Software><Solid><Specificity><Statistical Methods><Statistical Models><Techniques><Technology><Testing><Tissue Sample><Tissues><Variant><Variation><accelerated aging><accelerated biological age><accelerated biological aging><age acceleration><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging population><biological signal transduction><brain cell><brain tissue><cell type><clinical intervention><clinical therapy><cohort><complementation><computational methodology><computational methods><computer algorithm><computer based method><computer methods><computing method><cost><cost efficient><data interpretation><developmental><epigenome><genome scale><genome-wide><genomewide><global gene expression><global transcription profile><high dimensionality><improved><innovate><innovation><innovative><insight><kids><late onset alzheimer><mechanisms in AD><mechanisms in Alzheimer's disease><multiomics><multiple omic data><multiple omics><novel><panomics><parent><pathophysiology><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><population aging><primary degenerative dementia><progressive neurodegeneration><resolutions><sNuc-Seq><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell technology><single cell transcriptomic profiling><single nucleus RNA-sequencing><single nucleus seq><single-cell RNA sequencing><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><statistic methods><statistical linear mixed models><statistical linear models><statistics><tool><transcriptome><treatment strategy><trial regimen><trial treatment><youngster>

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Jingshen Wang

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$371,360

FY 2026

Project Title

Discovering Heterogeneous Causal Pathophysiology of Alzheimer's Disease

Grant Number:

5R01AG089512-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project summary Alzheimer's disease (AD) represents a critical public health burden. Fortunately, recent disease- modifying treatments for AD have demonstrated promising outcomes based on the successful trials of Lecanemab and Donanemab. Nevertheless, how and when these Amyloid-beta- lowering medica...

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Bradley C Lega

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 52/100

Likely hiring

Solid budget

Active award

$368,437

FY 2026

Project Title

Behavioral and pharmacological manipulation of time cell activity in the human mesial temporal lobe

Grant Number:

5R01NS125250-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2021

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Episodic memory describes our ability to weave temporally contiguous elements into recollections of rich and coherent experiences. Episodic memory formation is specifically degraded by degenerative conditions such as Alzheimer’s Disease. The activity of ‘time cells’ in the mesial tem...

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Erik Herzog

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 52/100

Likely hiring

Solid budget

Active award

$361,018

FY 2026

Project Title

Circadian regulation of neocortex

Grant Number:

5R01NS121161-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2021

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Little is known about the mechanisms that determine daily rhythms in rest-activity. We recently found that cells within the motor cortex can be synchronized to daily cycles of glucocorticoids. We hypothesize that daily suprachiasmatic nucleus activity and corticosterone secretion ent...

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DIANE C BASSHAM

IOWA STATE UNIVERSITY, AMES, IA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$325,530

FY 2026

Project Title

Crosstalk between brassinosteroid and autophagy pathways in the regulation of plant growth and stress responses

Grant Number:

5R01GM120316-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2017

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary The long-term goal of this project is to determine how growth, development and stress responses are coordinated in Arabidopsis, a model plant with extensive genetic, genomic and proteomic resources. This will be accomplished through detailed mechanistic studies that will provide insi...

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Justin William Walley

IOWA STATE UNIVERSITY, AMES, IA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$325,530

FY 2026

Project Title

Crosstalk between brassinosteroid and autophagy pathways in the regulation of plant growth and stress responses

Grant Number:

5R01GM120316-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2017

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary The long-term goal of this project is to determine how growth, development and stress responses are coordinated in Arabidopsis, a model plant with extensive genetic, genomic and proteomic resources. This will be accomplished through detailed mechanistic studies that will provide insi...

Research Terms

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YANHAI YIN

IOWA STATE UNIVERSITY, AMES, IA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$325,530

FY 2026

Project Title

Crosstalk between brassinosteroid and autophagy pathways in the regulation of plant growth and stress responses

Grant Number:

5R01GM120316-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2017

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary The long-term goal of this project is to determine how growth, development and stress responses are coordinated in Arabidopsis, a model plant with extensive genetic, genomic and proteomic resources. This will be accomplished through detailed mechanistic studies that will provide insi...

Research Terms

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Joshua Grill

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Good lead · 50/100

Training-friendly

Solid budget

Recent

Active award

$424,043

FY 2026

Project Title

NIA/AA for Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (NIA/AA IMPACT-AD Course)

Grant Number:

5R25AG076392-05

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary There is an urgent need for improved therapies for Alzheimer’s Disease and Related Dementias (ADRD). Critical to the mission to develop treatments for and curb the public health impact of ADRD will be a new generation of ADRD scientists, especially scientists with the unique training...

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Rema Raman

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Good lead · 50/100

Training-friendly

Solid budget

Recent

Active award

$424,043

FY 2026

Project Title

NIA/AA for Institute on Methods and Protocols for Advancement of Clinical Trials in ADRD (NIA/AA IMPACT-AD Course)

Grant Number:

5R25AG076392-05

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary There is an urgent need for improved therapies for Alzheimer’s Disease and Related Dementias (ADRD). Critical to the mission to develop treatments for and curb the public health impact of ADRD will be a new generation of ADRD scientists, especially scientists with the unique training...

Research Terms

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Bruce T Lamb

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 48/100

Large award

Active award

Team-scale grant

$8,319,175

FY 2026

Project Title

IUSM TREAT-AD Center

Grant Number:

5U54AG065181-07

Activity Code:

U54

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/30/2019

End Date:

11/30/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT The strategic goal of the Indiana University School of Medicine Purdue University TaRget Enablement to Accelerate Therapy Development for Alzheimer's Disease (IUSM-Purdue TREAT-AD) Center is to integrate sophisticated disease biology and drug discovery capabilities to creat...

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Alan D. Palkowitz

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 48/100

Large award

Active award

Team-scale grant

$8,319,175

FY 2026

Project Title

IUSM TREAT-AD Center

Grant Number:

5U54AG065181-07

Activity Code:

U54

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/30/2019

End Date:

11/30/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT The strategic goal of the Indiana University School of Medicine Purdue University TaRget Enablement to Accelerate Therapy Development for Alzheimer's Disease (IUSM-Purdue TREAT-AD) Center is to integrate sophisticated disease biology and drug discovery capabilities to creat...

Research Terms

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Timothy I Richardson

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 48/100

Large award

Active award

Team-scale grant

$8,319,175

FY 2026

Project Title

IUSM TREAT-AD Center

Grant Number:

5U54AG065181-07

Activity Code:

U54

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/30/2019

End Date:

11/30/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT The strategic goal of the Indiana University School of Medicine Purdue University TaRget Enablement to Accelerate Therapy Development for Alzheimer's Disease (IUSM-Purdue TREAT-AD) Center is to integrate sophisticated disease biology and drug discovery capabilities to creat...

Research Terms

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Xiaoyong Bao

UNIVERSITY OF TEXAS MED BR GALVESTON, GALVESTON, TX

Good lead · 48/100

Above-average budget

Very recent

Active award

$783,306

FY 2026

Project Title

tRNA-derived RNA Fragments (tRF) as Prognostic and Diagnostic Biomarkers for Alzheimer’s Disease

Grant Number:

4R33AG075725-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT tRNA-derived RNA Fragments (tRFs), a newly discovered family of non-coding RNAs (ncRNAs), are emerging as essential disease biomarkers and regulators. Our recent publication demonstrated that tRFs are the most impacted small ncRNAs (sncRNAs) by Alzheimer's disease (AD) in th...

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Xiang Fang

UNIVERSITY OF TEXAS MED BR GALVESTON, GALVESTON, TX

Good lead · 48/100

Above-average budget

Very recent

Active award

$783,306

FY 2026

Project Title

tRNA-derived RNA Fragments (tRF) as Prognostic and Diagnostic Biomarkers for Alzheimer’s Disease

Grant Number:

4R33AG075725-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT tRNA-derived RNA Fragments (tRFs), a newly discovered family of non-coding RNAs (ncRNAs), are emerging as essential disease biomarkers and regulators. Our recent publication demonstrated that tRFs are the most impacted small ncRNAs (sncRNAs) by Alzheimer's disease (AD) in th...

Research Terms

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Victor Han

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 48/100

Above-average budget

Very recent

Active award

$712,375

FY 2026

Project Title

A Single, Universal, and Digitally Programmable RF System Enables MRI of Any Nucleus

Grant Number:

1R37CA300386-01A1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract There are 118 known elements. Nearly all of them have nuclear magnetic resonance (NMR) active isotopes and at least 39 different nuclei from 33 elements have been used in biological and biomedical NMR studies. Despite the availability of dozens of NMR active isotopes (2H, 7Li, 13C, 17O, 23...

Research Terms

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Ali G Hamedani

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$235,577

FY 2026

Project Title

Vision and hallucinations in older adults

Grant Number:

5K23EY033438-05

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Visual hallucinations affect approximately 20% of Alzheimer disease and 50% of all Parkinson disease patients. Hallucinations are a leading source of patient and caregiver distress and are an independent risk factor for injury, nursing home placement, and mortality. Because treatment...

Research Terms

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Stephanie Anne-Carine Debette

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$154,789

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S5

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Carole Dufouil

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$154,789

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S5

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Mohammad Arfan Ikram

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$154,789

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S5

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Claudia L Satizabal

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$154,789

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S5

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Sudha Seshadri

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$154,789

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S5

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Astrid M Suchy-Dicey

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$154,789

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S5

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

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Yuliya Voskobiynyk

J. DAVID GLADSTONE INSTITUTES, SAN FRANCISCO, CA

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$122,850

FY 2026

Project Title

Microglial control of thalamocortical circuits in Alzheimer's disease

Grant Number:

1K99NS146256-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT Alzheimer’s disease (AD) is a neurodegenerative disorder affecting nearly five million Americans. Treatments are limited treatments and provide only modest benefits. Genome-wide association studies have identified TREM2 as one of the top AD risk genes. In particular, the T...

Research Terms

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Stephanie Anne-Carine Debette

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$102,360

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

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Carole Dufouil

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$102,360

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

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Mohammad Arfan Ikram

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$102,360

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

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Claudia L Satizabal

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$102,360

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

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Sudha Seshadri

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$102,360

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

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Astrid M Suchy-Dicey

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Likely hiring

Recent

Active award

$102,360

FY 2026

Project Title

Cognitively Healthy Nonagenarians in the Cross Cohort Collaboration (CCC)

Grant Number:

3R01AG059421-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Half of all persons who develop clinical dementia become symptomatic after age 85 years, whereas most studies of dementia have focused on younger patients in their 70s. Compared to dementia beginning at a younger age, dementia in the oldest-old has a more heterogeneous, multifactorial etiology. Alth...

Research Terms

View Full Project Details on NIH Reporter

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Nelly Cecile Joseph-Mathurin

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$94,049

FY 2026

Project Title

Evaluation of the neurovascular unit in the setting of pathogenesis and treatment of autosomal dominant Alzheimer disease

Grant Number:

5K01AG080123-04

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The overall objective of this proposal is to support the candidate’s career development and transition to that of an independent researcher. The outlined training plan will equip the applicant with the necessary skills to conduct innovative research in a rich, interdisciplinary, and ...

Research Terms

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Henry Matthew Lehrer

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$65,976

FY 2026

Project Title

Characterizing Alzheimer's Risk in Retired Night Shift Workers: Cognitive Function, Brain Volume, and Brain Bioenergetics - Supplement

Grant Number:

3K01AG075171-05S1

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/15/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Night shift work is common in the current 24-hour global society and is increasingly recognized as a risk factor for Alzheimer’s Disease (AD) and related dementias (ADRD). However, we know very little about the persistence, recovery from, or pathways through which shift work...

Research Terms

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Rory Cooley

UNIVERSITY OF CHICAGO, CHICAGO, IL

Good lead · 48/100

Training-friendly

Very recent

Active award

$50,114

FY 2026

Project Title

How do cortical hierarchies mediate visual categorization

Grant Number:

5F31EY036263-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project summary One of the primary goals of the primate brain is to learn about structure in the world, and to shape neural representations such that they encode this structure in an efficient, generalizable format. An important behavior that relies upon the formation of these abstract neural repres...

Research Terms

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Huaye Zhang

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Good lead · 48/100

Likely hiring

Recent

Active award

$50,000

FY 2026

Project Title

Polarity dysregulation in Alzheimer’s disease

Grant Number:

3RF1NS130881-01A1S1

Activity Code:

RF1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/6/2026

End Date:

1/5/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract This is an administrative supplement application to the parent grant to support the purchase of a new microscope system due to the unexpected failure of a critical component in our existing system. Due to the age of the existing microscope, manufacturing of the failed parts ...

Research Terms

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Sameer Afzal Ashaie

REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB, CHICAGO, IL

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$164,228

FY 2026

Project Title

Developing a daily life measure of depression for persons with aphasia and examining its relation with communicative confidence

Grant Number:

5K23DC020757-04

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Aphasia is a multi-modality disturbance of language that is often acquired after a left hemisphere stroke. Post-stroke depression is two times higher in persons with aphasia (PWAs) than in the general stroke population. Post-stroke depression is associated with worse language and cognitive performan...

Research Terms

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Dandan Diane Zheng

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, CORAL GABLES, FL

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$132,640

FY 2026

Project Title

Visual impairment and cognitive decline: understanding the longitudinal relationships and mechanisms

Grant Number:

5K01AG080120-04

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Visual impairment (VI) and cognitive impairment are chronic conditions that disproportionately affect older adults. Research has revealed a consistent relationship between VI and cognitive impairment and dementia in older adults. VI is a risk factor for Alzheimer disease (AD...

Research Terms

<21+ years old><AD and related dementia><AD associated neurodegeneration><AD dementia><AD neurodegeneration><AD related dementia><AD risk><AD risk factor><AD therapy><AD treatment><ADRD><Acceleration><Address><Adult><Adult Human><Affect><Aging><Alzheimer Type Dementia><Alzheimer associated neurodegeneration><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer related neurodegeneration><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease associated neurodegeneration><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease related neurodegeneration><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's therapy><Alzheimers Dementia><Amentia><Area><Brain><Brain Nervous System><Brain Vascular><Brain Vascular Disorders><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Causality><Cerebrovascular Disease><Cerebrovascular Disorders><Characteristics><Chronic><Clinical><Clinical assessments><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Complex><Contrast Sensitivity><Data><Data Sources><Dementia><Development><Diminished Vision><Disabling condition><Disabling health condition><Disease><Disorder><Disturbance in cognition><Encephalon><Epidemiology><Equation><Etiology><Eye diseases><Fostering><Future><Genetic><Genotype><Goals><Health><Impaired cognition><Intracranial Vascular Diseases><Intracranial Vascular Disorders><Investigators><K-Awards><K-Series Research Career Programs><Life><Link><Low Vision><Measures><Mediating><Mental Depression><Mentorship><Microvascular Dysfunction><Modeling><Nerve Degeneration><Neuron Degeneration><Older Population><Outcome><Partial Sight><Pathway interactions><Pattern><Play><Primary Senile Degenerative Dementia><Probabilistic Models><Probability Models><Psychological Factors><QOL><QOL improvement><Quality of life><Reduced Vision><Research><Research Career Program><Research Personnel><Researchers><Risk><Risk Factors><Role><Scientist><Sight><Social isolation><Statistical Methods><Statistical Models><Structure><Subnormal Vision><Techniques><Thick><Thickness><Training><Training Activity><Vision><Vision Disorders><Visual Acuity><Visual Contrast Sensitivity><Visual Disorder><Visual impairment><White Matter Hyperintensity><adulthood><aging process><alzheimer risk><biobank><biorepository><brain MR imaging><brain MRI><brain magnetic resonance imaging><brain vascular disease><brain vascular dysfunction><cardiovascular disease risk><cardiovascular disorder risk><causation><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><cerebral vascular><cerebral vascular disease><cerebral vascular dysfunction><cerebro-vascular><cerebrovascular><cerebrovascular dysfunction><cognitive dysfunction><cognitive function><cognitive loss><cognitive neuroscience><cognitive reserve><cohort><depression><developmental><disease causation><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><experience><eye disorder><improvements in QOL><improvements in quality of life><intracranial vascular dysfunction><malleable risk><microvascular complications><microvascular disease><mid life><mid-life><middle age><middle aged><midlife><modifiable risk><natural aging><neural degeneration><neural imaging><neuro-imaging><neurodegeneration><neurodegenerative><neuroimaging><neurological degeneration><neurological imaging><neuronal degeneration><normal aging><normative aging><novel><ocular disease><ocular disorder><older adult><older adulthood><older groups><older individuals><older person><ophthalmopathy><pathway><preservation><prevent><preventing><primary degenerative dementia><programs><psychologic><psychological><quality of life improvement><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sex><skills><social><social engagement><social involvement><social participation><social role><statistic methods><statistical linear mixed models><statistical linear models><statistics><training module><vision impairment><visual function><visually impaired>

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Ryan James Dougherty

RUTGERS, THE STATE UNIV OF N.J., PISCATAWAY, NJ

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$125,010

FY 2026

Project Title

Energy expenditure, cognitive function, and biomarker features of Alzheimer's disease

Grant Number:

5K01AG080122-05

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT This is an application for a Mentored Patient-Oriented Research Career Development Award (K01). The goal of the proposed project is to provide the candidate with advanced skills necessary to develop an independent research program focused on the association between physica...

Research Terms

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JIA-WEN GUO

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$423,500

FY 2026

Project Title

Decision-Making Capacity Assessment and Inclusive Decision-Making for Older Persons with Capacity Challenges

Grant Number:

1R21AG098947-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

An estimated 6.9 million Americans are currently living with Alzheimer’s dementia, a number expected to reach 12.7 million by 2050. People with dementia, along with others who have decisional limitations, face threats to their legal and autonomy rights to manage health care, residential, and other p...

Research Terms

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Maureen Henry

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$423,500

FY 2026

Project Title

Decision-Making Capacity Assessment and Inclusive Decision-Making for Older Persons with Capacity Challenges

Grant Number:

1R21AG098947-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

An estimated 6.9 million Americans are currently living with Alzheimer’s dementia, a number expected to reach 12.7 million by 2050. People with dementia, along with others who have decisional limitations, face threats to their legal and autonomy rights to manage health care, residential, and other p...

Research Terms

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Emily Drzymalla

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$41,757

FY 2026

Project Title

Metabolomic correlates of improved Alzheimer’s disease polygenic risk score for diverse populations

Grant Number:

1F31AG094260-01A1

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Alzheimer’s disease (AD), hypothesized to begin in midlife before symptoms appear, is the leading cause of dementia in the United States resulting in loss of cognitive function and eventual death. AD has a higher prevalence in non-Hispanic Black and Hispanic adults compared to non-Hi...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD pathway><AD related dementia><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><ADRD><Adult><Adult Human><Affect><African><African ancestry><African descent><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimers Dementia><Amentia><American><Amyloid><Amyloid Substance><Biological><Biological Markers><Biology><Black><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Cessation of life><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Computing Methodologies><Data><Data Set><Death><Degenerative Neurologic Disorders><Dementia><Development><Disease><Disorder><Disparities><Disparity><Disturbance in cognition><Epidemiology><Ethnic Origin><Ethnicity><European><Evaluation><Failure><GWA study><GWAS><Genetic><Genetic Research><Genetic Risk><Genomics><Heritability><High Prevalence><Hispanic><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Impaired cognition><Incidence><Individual><Intermediary Metabolism><Investigators><Knowledge><Link><Lipids><Measurement><Measures><Mentors><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Methods><Molecular><Molecular Epidemiology><NHLBI><National Heart, Lung, and Blood Institute><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurofibrillary Tangles><Neurologic Degenerative Conditions><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Participant><Pathogenesis><Pathologic><Pathway interactions><Performance><Population><Population Heterogeneity><Predicting Risk><Prevalence><Primary Senile Degenerative Dementia><Publishing><Race><Races><Research><Research Personnel><Researchers><Role><Sample Size><Scoring Method><Statistical Methods><Symptoms><Synapses><Synaptic><TOPMed><Testing><Time><Training><Trans-Omics for Precision Medicine><United States><Variant><Variation><adulthood><ages><alzheimer risk><bio-markers><biobank><biologic><biologic marker><biomarker><biomarker development><biorepository><blood lipid><career><cognitive dysfunction><cognitive function><cognitive loss><cohort><computational methodology><computational methods><computer based method><computer methods><computing method><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><dementia risk><developmental><disease epidemiology><disparity in health><diverse populations><epidemiologic><epidemiological><evidence base><experience><forecasting risk><genetic analysis><genetic architecture><genetic epidemiologic study><genetic epidemiology><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><health disparity><health disparity community><health disparity group><health disparity populations><heterogeneous population><improved><innovate><innovation><innovative><insight><instrument><mechanisms in AD><mechanisms in Alzheimer's disease><metabolism measurement><metabolomics><metabonomics><mid life><mid-life><middle age><middle aged><midlife><neurodegenerative illness><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><novel><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><polygenetic risk scores><polygenic risk score><population diversity><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><primary degenerative dementia><racial><racial background><racial origin><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><risk prediction><risk predictions><senile dementia of the Alzheimer type><skills><social role><statistic methods><statistics><synapse><tangle><therapeutic effectiveness><trait><whole genome association analysis><whole genome association study>

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Philip Anthony Anglewicz

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 38/100

Very recent

Active award

Team-scale grant

$166,376

FY 2026

Project Title

Building Research Infrastructure for Alzheimer's Disease and Related Dementias in Cote d'Ivoire

Grant Number:

5UG3AG090673-02

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Most research on Alzheimer’s Disease and Alzheimer’s-Related Dementias (AD/ADRD) is set in higher income contexts in North America, Europe, and Asia, yet (1) the burden of AD/ADRD is rapidly increasing in low- and middle-income countries (LMICs), particularly in sub-Saharan Africa (S...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><Address><Adult><Adult Human><Africa South of the Sahara><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Asia><Canada><Causality><Characteristics><Collaborations><Cote d'Ivoire><Country><Data><Data Collection><Dementia><Development><Disease><Disorder><Economic Income><Economical Income><Etiology><Europe><Faculty><Family Planning><Family Planning Services><Geography><Goals><Grant><Health Planning><Income><Infrastructure><Institution><Interviewer><Ivory Coast><LMIC><Language><Learning><Manuscripts><Measurement><Measures><Mentors><Monitor><Neurosciences><North America><Older Population><Pattern><Performance><Phase><Policies><Population><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Psychological Factors><Public Health Schools><Reproductive Health><Research><Research Infrastructure><Respondent><Risk Factors><Role><Sampling><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Sub-Saharan Africa><Subsaharan Africa><Supervision><Survey Instrument><Surveys><System><Training><Translating><United States><Weight><Woman><adulthood><aged><aging associated><aging related><alzheimer risk><causation><cognitive assessment><cognitive testing><data harmonization><data quality><developmental><disease causation><electronic data><harmonized data><incomes><instrument><labor force participation><low and middle-income countries><men><older groups><older individuals><older person><plan health><primary degenerative dementia><programs><psychosocial><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><rural area><rural location><rural region><scale up><senile dementia of the Alzheimer type><skills><social factors><social role><statistical analysis><tool><weights>

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Rosine Addy Mosso

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 38/100

Very recent

Active award

Team-scale grant

$166,376

FY 2026

Project Title

Building Research Infrastructure for Alzheimer's Disease and Related Dementias in Cote d'Ivoire

Grant Number:

5UG3AG090673-02

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Most research on Alzheimer’s Disease and Alzheimer’s-Related Dementias (AD/ADRD) is set in higher income contexts in North America, Europe, and Asia, yet (1) the burden of AD/ADRD is rapidly increasing in low- and middle-income countries (LMICs), particularly in sub-Saharan Africa (S...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><Address><Adult><Adult Human><Africa South of the Sahara><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Asia><Canada><Causality><Characteristics><Collaborations><Cote d'Ivoire><Country><Data><Data Collection><Dementia><Development><Disease><Disorder><Economic Income><Economical Income><Etiology><Europe><Faculty><Family Planning><Family Planning Services><Geography><Goals><Grant><Health Planning><Income><Infrastructure><Institution><Interviewer><Ivory Coast><LMIC><Language><Learning><Manuscripts><Measurement><Measures><Mentors><Monitor><Neurosciences><North America><Older Population><Pattern><Performance><Phase><Policies><Population><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Psychological Factors><Public Health Schools><Reproductive Health><Research><Research Infrastructure><Respondent><Risk Factors><Role><Sampling><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Sub-Saharan Africa><Subsaharan Africa><Supervision><Survey Instrument><Surveys><System><Training><Translating><United States><Weight><Woman><adulthood><aged><aging associated><aging related><alzheimer risk><causation><cognitive assessment><cognitive testing><data harmonization><data quality><developmental><disease causation><electronic data><harmonized data><incomes><instrument><labor force participation><low and middle-income countries><men><older groups><older individuals><older person><plan health><primary degenerative dementia><programs><psychosocial><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><rural area><rural location><rural region><scale up><senile dementia of the Alzheimer type><skills><social factors><social role><statistical analysis><tool><weights>

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Alexander Riordan

PRINCETON UNIVERSITY, Princeton, NJ

Exploratory lead · 38/100

Very recent

Active award

Career award

$90,325

FY 2026

Project Title

Circuit Reconstruction of Functionally-Identified Neurons in Deep Brain Regions: Application to Grid Cells

Grant Number:

5K00NS115338-06

Activity Code:

K00

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2019

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Abstract Specialized synaptic wiring motifs have been suspected to be essential building blocks of cognition since the birth of modern neuroscience. However the technology to test these ideas has been historically unavailable. The grid cell system in medial entorhinal cortex (MEC), a deep br...

Research Terms

<2-photon><3-D><3-Dimensional><3D><AD dementia><Academia><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Anatomic Sites><Anatomic structures><Anatomy><Animals><Architecture><Area><Autopsy><Behavior><Behavioral><Birth><Body Tissues><Brain><Brain Nervous System><Brain imaging><Brain region><Calcium><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cognition><Cognitive><Complex><Data><Development><Dorsal><Electron Microscopy><Encephalon><Engineering><Engineering / Architecture><Entorhinal Area><Environment><Foundations><Functional Imaging><Future><Head><Health><Hippocampal Formation><Image><Implant><Investigators><Location><Medial><Memory><Methods><Mice><Mice Mammals><Microscope><Modeling><Modernization><Monitor><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurosciences><Operative Procedures><Operative Surgical Procedures><Optics><Parturition><Pattern><Phase><Photons><Physiologic Imaging><Postdoc><Postdoctoral Fellow><Primary Senile Degenerative Dementia><Probability><Procedures><Productivity><Recurrence><Recurrent><Research><Research Associate><Research Personnel><Researchers><Rodent><Rodentia><Rodents Mammals><Rotation><Subcellular Process><Surface><Surgical><Surgical Interventions><Surgical Procedure><Synapses><Synaptic><System><Techniques><Technology><Testing><Tissues><Training><Work><anatomic imaging><anatomical imaging><awake><brain visualization><career><connectome><design><designing><developmental><entorhinal cortex><experiment><experimental research><experimental study><experiments><functional group><imaging><insight><instrument><instrumentation><method development><multi-modality><multi-photon><multi-photon imaging><multidisciplinary><multimodality><multiphoton imaging><necropsy><neural><neural circuit><neural circuitry><neurocircuitry><neuronal><next generation><novel><optical><physiological imaging><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><postmortem><primary degenerative dementia><reconstruction><research associates><response><senile dementia of the Alzheimer type><skills><surgery><synapse><synaptic circuit><synaptic circuitry><theories><three dimensional><two-photon><virtual><virtual reality>

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Frank Porreca

UNIVERSITY OF ARIZONA, TUCSON, AZ

Exploratory lead · 34/100

Training-friendly

Active award

$134,905

FY 2026

Project Title

High School Student NeuroResearch Program (HSNRP)

Grant Number:

5R25NS076437-13

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2011

End Date:

11/30/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

University of Arizona's High School Student NeuroResearch (NR) Program (HSNRP) nurtures, trains, and sustains the spirit of inquiry in a growing diverse, connected workforce pipeline and faculty peer/near peer support network. Over the next 5 years, HSNRP will offer annually 10 talented, motivated A...

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MARLYS Hearst WITTE

UNIVERSITY OF ARIZONA, TUCSON, AZ

Exploratory lead · 34/100

Training-friendly

Active award

$134,905

FY 2026

Project Title

High School Student NeuroResearch Program (HSNRP)

Grant Number:

5R25NS076437-13

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2011

End Date:

11/30/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

University of Arizona's High School Student NeuroResearch (NR) Program (HSNRP) nurtures, trains, and sustains the spirit of inquiry in a growing diverse, connected workforce pipeline and faculty peer/near peer support network. Over the next 5 years, HSNRP will offer annually 10 talented, motivated A...

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Russell S Witte

UNIVERSITY OF ARIZONA, TUCSON, AZ

Exploratory lead · 34/100

Training-friendly

Active award

$134,905

FY 2026

Project Title

High School Student NeuroResearch Program (HSNRP)

Grant Number:

5R25NS076437-13

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2011

End Date:

11/30/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

University of Arizona's High School Student NeuroResearch (NR) Program (HSNRP) nurtures, trains, and sustains the spirit of inquiry in a growing diverse, connected workforce pipeline and faculty peer/near peer support network. Over the next 5 years, HSNRP will offer annually 10 talented, motivated A...

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Matthew Francis Challman

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Exploratory lead · 34/100

Training-friendly

Active award

$55,114

FY 2026

Project Title

The regulation of the microglial response to amyloid-beta plaques by the polycomb repressive complex 2

Grant Number:

5F30AG079492-04

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract A gap exists in our understanding of the pathophysiology behind Alzheimer’s Disease (AD), which has led to virtually nonexistent treatment options. Recent studies have identified microglia, the innate immune cells of the brain, as key players in the response to AD that may h...

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Corey St. Romain

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Exploratory lead · 34/100

Training-friendly

Active award

$50,349

FY 2026

Project Title

Genetic resiliency to disease progression in Alzheimer's disease

Grant Number:

5F30AG085919-03

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Alzheimer’s disease (AD) is marked by impaired cognition and memory loss. AD patients also exhibit 5–10-fold increased incidence of seizure activity compared to age-matched controls, with one study finding 42% experienced subclinical epileptiform activity using extended EEG ...

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Kevin Kaiwen Qi

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Exploratory lead · 34/100

Training-friendly

Active award

$46,524

FY 2026

Project Title

Population dynamics in the medial entorhinal cortex of freely flying Egyptian fruit bats

Grant Number:

1F31NS143343-01A1

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2026

End Date:

2/28/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT The internal representation of space in the mammalian brain is crucial for supporting an animal's ability to navigate complex environments. Grid cells in the medial entorhinal cortex (MEC) are believed to provide a reliable and scalable representation of an animal's posit...

Research Terms

<3-D><3-Dimensional><3D><AD dementia><Address><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Ammon Horn><Animal Behavior><Animals><Bats><Behavior><Behavioral><Brain><Brain Nervous System><Brain region><Cell Body><Cell model><Cells><Cellular model><Chiroptera><Code><Coding System><Complex><Cornu Ammonis><Cyclicity><Egyptian><Electrophysiology><Electrophysiology (science)><Encephalon><Entorhinal Area><Environment><Episodic memory><Ethology><Evolution><Exhibits><Fellowship><Flying body movement><Fruit><Goals><Head><Hippocampus><Histologic><Histologically><Human><Intervention><Knowledge><Linear Regressions><Medial><Modeling><Modern Man><Nature><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Neurophysiology / Electrophysiology><Neurosciences><Pattern><Periodicals><Periodicity><Population><Population Dynamics><Position><Positioning Attribute><Primary Senile Degenerative Dementia><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Project Grants><Research Projects><Rhythmicity><Rodent><Rodentia><Rodents Mammals><Role><Spatial Behavior><Speed><Structure><Techniques><Technology><Testing><Therapeutic><Time><Training><Work><density><dietary fruit><electrophysiological><entorhinal cortex><flying><hippocampal><insight><medial temporal area><medial temporal lobe><mesial temporal area><mesial temporal lobe><network models><neural><neurological disease><periodic><periodical><preservation><primary degenerative dementia><response><senile dementia of the Alzheimer type><single cell analysis><social role><spatial memory><three dimensional><wireless>

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Jerry L Chen

BOSTON UNIVERSITY (CHARLES RIVER CAMPUS), BOSTON, MA

Exploratory lead · 32/100

Solid budget

Recent

Active award

$449,625

FY 2026

Project Title

Molecular Cellular and Circuit Level Mechanisms of Working Memory Maintenance

Grant Number:

1R21MH140102-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

3/14/2028

Project Abstract

PROJECT SUMMARY Working memory allows past events to be transiently maintained in the brain so that it can be compared with ongoing experiences to drive behavior. This cognitive process has been shown to be severely impacted by the progression of many neuropsychiatric diseases and disorders. Thus, i...

Research Terms

<2-photon><AD dementia><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Animals><Area><BRAIN initiative><Behavior><Behavioral><Biological><Brain><Brain Nervous System><Brain Research through Advancing Innovative Neurotechnologies initiative><Brain region><Calcium><Cell Body><Cells><Communication><Disease><Disorder><Dissection><Encephalon><Environment><Event><Expression Signature><Foundations><Gene Expression><Gene Expression Profile><Genes><Image><Immediate Memory><Information Storage><Ion Channel><Ionic Channels><Link><Maintenance><Maps><Measurement><Measures><Membrane><Membrane Channels><Mental Health><Mental Hygiene><Mice><Mice Mammals><Modeling><Molecular><Monitor><Murine><Mus><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neurocyte><Neurologic Body System><Neurologic Organ System><Neurons><Noise><Population><Population Dynamics><Position><Positioning Attribute><Primary Senile Degenerative Dementia><Process><Property><Psychological Health><Recurrence><Recurrent><Resistance><Resolution><Retrieval><Schizophrenia><Schizophrenic Disorders><Sensory><Short-Term Memory><Signaling Molecule><Specificity><Stimulus><Synapses><Synaptic><Testing><Thalamic structure><Thalamus><Tracer><United States National Institutes of Health><Work><anatomical tracing><biologic><cell type><cognitive function><cognitive process><dementia praecox><experience><frontal cortex><frontal lobe><gene expression pattern><gene expression signature><imaging><insight><membrane structure><mental function><neural><neural circuit><neural circuitry><neural network><neurocircuitry><neuronal><neuropsychiatric disease><neuropsychiatric disorder><optogenetics><primary degenerative dementia><resistant><resolutions><schizophrenic><segregation><senile dementia of the Alzheimer type><sensory cortex><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><synapse><synaptic circuit><synaptic circuitry><thalamic><theories><tool><transcriptional profile><transcriptional signature><two-photon><working memory>

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JAMES Gerard HEYS

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 32/100

Solid budget

Recent

Active award

$423,500

FY 2026

Project Title

An Integrated Circuit Model for Temporal Coding in Lateral and Medial Entorhinal Cortex

Grant Number:

1R21MH140161-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

3/14/2028

Project Abstract

Project Summary/Abstract Interval timing, the ability to estimate event durations on the scale of seconds to minutes, is crucial for adaptive behaviors. Prior work investigating the neural basis of interval timing has focused on brain circuits in the basal ganglia and frontal and parietal cortices. ...

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Carmen Varela

FLORIDA STATE UNIVERSITY, TALLAHASSEE, FL

Exploratory lead · 32/100

Solid budget

Recent

Active award

$296,232

FY 2026

Project Title

Investigating Thalamocortical Spike Dynamics to Increase Sleep Stability and Memory in Alzheimer’s Disease

Grant Number:

1R03AG093243-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/29/2028

Project Abstract

Our long-term objective is to determine how thalamic networks contribute to sleep and memory in the normal and diseased brain. The goal of this project is to investigate the basic mechanisms by which the spike dynamics in cognitive thalamic circuits contribute to sleep stability and memory consolida...

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Kaisu Marja Lankinen

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 30/100

Very recent

Active award

$208,750

FY 2026

Project Title

Role of connectivity between hippocampus and auditory cortex in adverse listening conditions

Grant Number:

5R21DC021766-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This project investigates the role of the hippocampus (HC) in adverse listening conditions in human subjects using high resolution 7 Tesla functional magnetic resonance imaging (fMRI). Although HC has traditionally been studied predominantly as a visuospatial processor, evidence is emerging that it ...

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KATHERINE ELIZABETH PRATER

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 30/100

Recent

Active award

Career award

$188,892

FY 2026

Project Title

Microglial subpopulations that contribute to resilience to Alzheimers disease

Grant Number:

5K22AG082712-02

Activity Code:

K22

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Alzheimer’s Disease (AD) is the most common form of dementia, with over 5 million individuals currently suffering from this neurodegenerative disorder. Despite the prevalence of AD, many individuals live into their 90s without any cognitive decline. A subset of these cogniti...

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Stacey J Rizzo

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 30/100

Very recent

Active award

$49,394

FY 2026

Project Title

Improving Preclinical Translation in Alzheimer's Disease Research

Grant Number:

5R13AG060708-08

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2018

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Our long-term goal is to ensure that rigorous, best-practice scientific methods are consistently applied in experiments generating preclinical data for potential therapies for Alzheimer’s disease (AD). The number of AD cases is rising dramatically worldwide, and there is an ...

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DENISE HEAD

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 26/100

Solid budget

Active award

$427,625

FY 2026

Project Title

Age Differences in the Acquisition and Retention of Flexible Navigation Behaviors

Grant Number:

1R21AG098547-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT Difficulties finding one’s way in novel environments may lead to anxiety and restrictions in daily activities for older adults. There is a substantial literature documenting age-related deficits in spatial navigation, with particular deficits observed in the acquisition, ret...

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Emily Aster Aery Jones

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Exploratory lead · 22/100

Recent

Active award

$248,936

FY 2026

Project Title

Dynamics of Hippocampal Inputs in Alzheimer's Disease

Grant Number:

4R00NS134734-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/18/2023

End Date:

8/31/2028

Project Abstract

Project Summary In the US, Alzheimer’s disease (AD) is the sixth leading cause of death, affects 11% of the population over age 65, and costs $355 billion each year. One of the first impairments in AD is spatial memory, which involves the hippocampal area CA1. CA1 encodes new information, driven by ...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD dementia><AD model><AD pathway><AD therapy><AD treatment><AD-associated pathways><AD-related pathways><AD-specific pathways><Address><Advisory Committees><Affect><Age><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer disease treatment><Alzheimer pathway><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's disease model><Alzheimer's disease therapy><Alzheimer's mechanism><Alzheimer's related pathways><Alzheimer's therapy><Alzheimers Dementia><Ammon Horn><Area><Automobile Driving><Cause of Death><Chronic><Cognition><Cornu Ammonis><Cyclic Somatostatin><Data><Dysfunction><Electrophysiology><Electrophysiology (science)><Entorhinal Area><Environment><Faculty><Fire - disasters><Fires><Functional disorder><Future><Goals><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Hippocampus><Impairment><Intervention><Learning><Maps><Measures><Medial><Memory><Memory Deficit><Memory Loss><Memory impairment><Mentors><Mentorship><Mice><Mice Mammals><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuron Degeneration><Neuronal Dysfunction><Neurons><Neurophysiology / Electrophysiology><Parvalbumins><Pathway interactions><Pattern><Phase><Physiopathology><Play><Population><Position><Positioning Attribute><Primary Senile Degenerative Dementia><Qualifying><Research><Research Resources><Resources><Rest><Retrieval><Role><SRIH><SRIH-14><Somatostatin><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><Task Forces><Techniques><Testing><Training><Universities><above age 65><advisory team><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged><aged 65 and greater><aged 65+><aged ≥65><ages><alzheimer model><cost><driving><electrophysiological><entorhinal cortex><evidence base><experiment><experimental research><experimental study><experiments><fire><growth hormone release inhibiting factor><hippocampal><human old age (65+)><implant design><in vivo><inhibitory neuron><mechanisms in AD><mechanisms in Alzheimer's disease><memory decline><memory dysfunction><molecular pathology><mouse model><murine model><nerve cell death><nerve cell loss><neural><neural degeneration><neural dysfunction><neurodegeneration><neurodegenerative><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><novel><optogenetics><over 65 years><pathophysiology><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><primary degenerative dementia><senile dementia of the Alzheimer type><social role><spatial memory><statistics><translational neuroscience><≥65 years>

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Roberto Adamo Gulli

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Exploratory lead · 22/100

Recent

Active award

$248,896

FY 2026

Project Title

Elucidating the Neural Computations Underlying Spatial Learning, Decision-Making and Generalization in Virtually-Navigating Monkeys

Grant Number:

4R00NS133475-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

2/28/2029

Project Abstract

Project Summary/Abstract Patients with Alzheimer’s disease and Alzheimer’s disease-related dementias exhibit symptoms that include deficits in spatial navigation, and in forming/using cognitive maps of space to guide decision-making, especially in new environmental situations. These deficits are li...

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DIANA MATALLANA

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 22/100

Recent

Active award

$208,976

FY 2026

Project Title

Research Training in Alzheimer's Disease and Brain Health in Colombia

Grant Number:

3D43TW012455-03S1

Activity Code:

D43

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Project Abstract

This D43 grant application aims to sustainably strengthen the research capacity of the Universidad Javeriana in Bogotá, Colombia with an emphasis on training in-country experts to develop and conduct research focused on Alzheimer’s disease and related dementias (ADRD). Our application is in response...

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Hernando Santamaria-Garcia

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 22/100

Recent

Active award

$208,976

FY 2026

Project Title

Research Training in Alzheimer's Disease and Brain Health in Colombia

Grant Number:

3D43TW012455-03S1

Activity Code:

D43

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Project Abstract

This D43 grant application aims to sustainably strengthen the research capacity of the Universidad Javeriana in Bogotá, Colombia with an emphasis on training in-country experts to develop and conduct research focused on Alzheimer’s disease and related dementias (ADRD). Our application is in response...

Research Terms

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VICTOR VALCOUR

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 22/100

Recent

Active award

$208,976

FY 2026

Project Title

Research Training in Alzheimer's Disease and Brain Health in Colombia

Grant Number:

3D43TW012455-03S1

Activity Code:

D43

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Project Abstract

This D43 grant application aims to sustainably strengthen the research capacity of the Universidad Javeriana in Bogotá, Colombia with an emphasis on training in-country experts to develop and conduct research focused on Alzheimer’s disease and related dementias (ADRD). Our application is in response...

Research Terms

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Thomas Kofi Mensah Cudjoe

FOUNDATION FOR SOCIAL CONNECTION, WASHINGTON, DC

Exploratory lead · 22/100

Recent

Active award

$50,000

FY 2026

Project Title

Advancing the Science of Social Connection Across the Life-Course: The Next Generation of Measurement in the United States

Grant Number:

1R13AG090015-01A1

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2027

Project Abstract

PROJECT ABSTRACT Social isolation, loneliness, and social connection are gaining global attention due to their profound impacts on the health and well-being of older adults. In 2023, advisories by the Office of the Surgeon General, legislation introduced by United States Senator Murphy and Represent...

Research Terms

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Ashwin Ajit Kotwal

FOUNDATION FOR SOCIAL CONNECTION, WASHINGTON, DC

Exploratory lead · 22/100

Recent

Active award

$50,000

FY 2026

Project Title

Advancing the Science of Social Connection Across the Life-Course: The Next Generation of Measurement in the United States

Grant Number:

1R13AG090015-01A1

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2027

Project Abstract

PROJECT ABSTRACT Social isolation, loneliness, and social connection are gaining global attention due to their profound impacts on the health and well-being of older adults. In 2023, advisories by the Office of the Surgeon General, legislation introduced by United States Senator Murphy and Represent...

Research Terms

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Jillian Racoosin

FOUNDATION FOR SOCIAL CONNECTION, WASHINGTON, DC

Exploratory lead · 22/100

Recent

Active award

$50,000

FY 2026

Project Title

Advancing the Science of Social Connection Across the Life-Course: The Next Generation of Measurement in the United States

Grant Number:

1R13AG090015-01A1

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2027

Project Abstract

PROJECT ABSTRACT Social isolation, loneliness, and social connection are gaining global attention due to their profound impacts on the health and well-being of older adults. In 2023, advisories by the Office of the Surgeon General, legislation introduced by United States Senator Murphy and Represent...

Research Terms

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DIANA MATALLANA

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 22/100

Recent

Active award

$17,664

FY 2026

Project Title

Research Training in Alzheimer's Disease and Brain Health in Colombia

Grant Number:

3D43TW012455-03S2

Activity Code:

D43

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Project Abstract

This D43 grant application aims to sustainably strengthen the research capacity of the Universidad Javeriana in Bogotá, Colombia with an emphasis on training in-country experts to develop and conduct research focused on Alzheimer’s disease and related dementias (ADRD). Our application is in response...

Research Terms

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Hernando Santamaria-Garcia

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 22/100

Recent

Active award

$17,664

FY 2026

Project Title

Research Training in Alzheimer's Disease and Brain Health in Colombia

Grant Number:

3D43TW012455-03S2

Activity Code:

D43

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Project Abstract

This D43 grant application aims to sustainably strengthen the research capacity of the Universidad Javeriana in Bogotá, Colombia with an emphasis on training in-country experts to develop and conduct research focused on Alzheimer’s disease and related dementias (ADRD). Our application is in response...

Research Terms

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VICTOR VALCOUR

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 22/100

Recent

Active award

$17,664

FY 2026

Project Title

Research Training in Alzheimer's Disease and Brain Health in Colombia

Grant Number:

3D43TW012455-03S2

Activity Code:

D43

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Project Abstract

This D43 grant application aims to sustainably strengthen the research capacity of the Universidad Javeriana in Bogotá, Colombia with an emphasis on training in-country experts to develop and conduct research focused on Alzheimer’s disease and related dementias (ADRD). Our application is in response...

Research Terms

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DIANA MATALLANA

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 22/100

Recent

Active award

$16,004

FY 2026

Project Title

Research Training in Alzheimer's Disease and Brain Health in Colombia

Grant Number:

5D43TW012455-03

Activity Code:

D43

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Project Abstract

This D43 grant application aims to sustainably strengthen the research capacity of the Universidad Javeriana in Bogotá, Colombia with an emphasis on training in-country experts to develop and conduct research focused on Alzheimer’s disease and related dementias (ADRD). Our application is in response...

Research Terms

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Hernando Santamaria-Garcia

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 22/100

Recent

Active award

$16,004

FY 2026

Project Title

Research Training in Alzheimer's Disease and Brain Health in Colombia

Grant Number:

5D43TW012455-03

Activity Code:

D43

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Project Abstract

This D43 grant application aims to sustainably strengthen the research capacity of the Universidad Javeriana in Bogotá, Colombia with an emphasis on training in-country experts to develop and conduct research focused on Alzheimer’s disease and related dementias (ADRD). Our application is in response...

Research Terms

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VICTOR VALCOUR

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 22/100

Recent

Active award

$16,004

FY 2026

Project Title

Research Training in Alzheimer's Disease and Brain Health in Colombia

Grant Number:

5D43TW012455-03

Activity Code:

D43

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Project Abstract

This D43 grant application aims to sustainably strengthen the research capacity of the Universidad Javeriana in Bogotá, Colombia with an emphasis on training in-country experts to develop and conduct research focused on Alzheimer’s disease and related dementias (ADRD). Our application is in response...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Celine Drieu

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 16/100

Active award

$249,000

FY 2026

Project Title

Role of multi-regional neuronal reactivations in reward-based memories

Grant Number:

4R00DA059024-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

12/31/2028

Project Abstract

PROJECT SUMMARY The goal of this project is to provide the building blocks for an independent research program focused on the neural basis of reward-based memory across distributed brain networks. Humans and other animals experience events in the moments they occur while the brain has evolved powerf...

Research Terms

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Xu Qin

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 16/100

Active award

$223,754

FY 2026

Project Title

Heterogeneous genetics effects and mediation in Alzheimer's disease

Grant Number:

5R21AG087057-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

Project Summary Down syndrome (DS) is the most common genetic intellectual and developmental disability and has historically been associated with poor life expectancy. However, improvements in medical care have increased the lifespan of individuals with DS to above 60 years. Individuals with DS hav...

Research Terms

<21+ years old><A β-42><A β42><A-beta 42><A-beta42><AD biological marker><AD biomarker><AD dementia><AD pathology><AD pathway><AD related biomarker><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><APOE><Abeta synthesis><Abeta-42><Abeta42><Acceleration><Accounting><Adult><Adult Human><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's pathology><Alzheimer's precursor protein><Alzheimer's related biomarker><Alzheimer's related pathways><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Amyloid (Aβ) plaques><Amyloid A4 Protein Precursor><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Protein Precursor><Amyloid beta-42><Amyloid beta-Protein><Amyloid beta-Protein Precursor><Amyloid beta42><Amyloid β><Amyloid β production><Amyloid β synthesis><Amyloid β-42><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β-Protein Precursor><Amyloid β42><Amyloidβ-42><Amyloidβ42><Apo-E><ApoE protein><Apolipoprotein E><Aβ><Aβ production><Aβ synthesis><Aβ-42><Aβ42><Bayesian Analysis><Bayesian computation><Bayesian inference><Bayesian network analysis><Bayesian spatial analysis><Bayesian statistical analysis><Bayesian statistical inference><Bayesian statistics><Biological><Biological Markers><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Caring><Causality><Chromosome 21><Clinical><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Data><Data Set><Dementia><Deposit><Deposition><Disease><Disease Marker><Disease Progression><Disorder><Disturbance in cognition><Down Syndrome><Early Diagnosis><Etiology><Family><Family Characteristics><Family Health><Family Medical History><Family Medical History Epidemiology><Family health status><Family history of><Gene Proteins><Genes><Genetic><Genotype><Goals><Heart Vascular><Heterogeneity><History><Hypothyroidism><Image><Impaired cognition><Increase lifespan><Individual><Individuals with down syndrome><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Isoforms><Langdon Down syndrome><Life Expectancy><Link><Machine Learning><Mediating><Mediation><Medical><Medical History><Methodology><Methods><Modeling><Modification><Mongolism><Negotiating><Negotiation><Neuritic Plaques><Pathologic><Pathology><Pathway interactions><Patients><Personal Medical History><Personal Medical History Epidemiology><Population><Primary Senile Degenerative Dementia><Process><Protein Gene Products><Protein Isoforms><Recording of previous events><Research><Role><Sampling><Senile Plaques><Siblings><Sleep Apnea><Sleep Apnea Syndromes><Sleep Hypopnea><Sleep-Disordered Breathing><Source><Statistical Methods><Study models><Testing><Therapeutic Intervention><Training><Trees><Trisomy 21><a beta peptide><abeta><abeta production><adulthood><alzheimer risk><amyloid beta><amyloid beta plaque><amyloid beta production><amyloid beta synthesis><amyloid precursor protein><amyloid-b plaque><amyloid-b protein><autosomal dominant AD><autosomal dominant Alzheimer's disease><aβ plaques><beta amyloid fibril><bio-markers><biologic><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><boost longevity><cardiovascular disorder><causation><chromosome 21 trisomy><chromosome 21 trisomy syndrome><circulatory system><cognitive dysfunction><cognitive loss><computer based prediction><congenital acromicria syndrome><cored plaque><data sharing><demographics><design><designing><develop software><developing computer software><diffuse plaque><disease causation><down syndrome individuals><down syndrome patients><early detection><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><flexibility><flexible><foster longevity><histories><imaging><improve lifespan><improve longevity><improved><inclusion criteria><innovate><innovation><innovative><intellectual and developmental disability><intervention therapy><lifespan extension><limited intellectual functioning><machine based learning><mechanisms in AD><mechanisms in Alzheimer's disease><morbus Down><novel><overexpress><overexpression><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><patients with down syndrome><people with down syndrome><pre-clinical><preclinical><predictive modeling><primary degenerative dementia><prolong lifespan><prolong longevity><promote lifespan><promote longevity><pseudohypertrophic progressive muscular dystrophy><regression trees><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sleep-related breathing disorder><social role><software development><soluble amyloid precursor protein><statistic methods><support longevity><symptomatology><targeted agent><trisomy 21 syndrome>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Victor Talisa

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 16/100

Active award

$223,754

FY 2026

Project Title

Heterogeneous genetics effects and mediation in Alzheimer's disease

Grant Number:

5R21AG087057-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

Project Summary Down syndrome (DS) is the most common genetic intellectual and developmental disability and has historically been associated with poor life expectancy. However, improvements in medical care have increased the lifespan of individuals with DS to above 60 years. Individuals with DS hav...

Research Terms

<21+ years old><A β-42><A β42><A-beta 42><A-beta42><AD biological marker><AD biomarker><AD dementia><AD pathology><AD pathway><AD related biomarker><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><APOE><Abeta synthesis><Abeta-42><Abeta42><Acceleration><Accounting><Adult><Adult Human><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's pathology><Alzheimer's precursor protein><Alzheimer's related biomarker><Alzheimer's related pathways><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Amyloid (Aβ) plaques><Amyloid A4 Protein Precursor><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Protein Precursor><Amyloid beta-42><Amyloid beta-Protein><Amyloid beta-Protein Precursor><Amyloid beta42><Amyloid β><Amyloid β production><Amyloid β synthesis><Amyloid β-42><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β-Protein Precursor><Amyloid β42><Amyloidβ-42><Amyloidβ42><Apo-E><ApoE protein><Apolipoprotein E><Aβ><Aβ production><Aβ synthesis><Aβ-42><Aβ42><Bayesian Analysis><Bayesian computation><Bayesian inference><Bayesian network analysis><Bayesian spatial analysis><Bayesian statistical analysis><Bayesian statistical inference><Bayesian statistics><Biological><Biological Markers><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Caring><Causality><Chromosome 21><Clinical><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Data><Data Set><Dementia><Deposit><Deposition><Disease><Disease Marker><Disease Progression><Disorder><Disturbance in cognition><Down Syndrome><Early Diagnosis><Etiology><Family><Family Characteristics><Family Health><Family Medical History><Family Medical History Epidemiology><Family health status><Family history of><Gene Proteins><Genes><Genetic><Genotype><Goals><Heart Vascular><Heterogeneity><History><Hypothyroidism><Image><Impaired cognition><Increase lifespan><Individual><Individuals with down syndrome><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Isoforms><Langdon Down syndrome><Life Expectancy><Link><Machine Learning><Mediating><Mediation><Medical><Medical History><Methodology><Methods><Modeling><Modification><Mongolism><Negotiating><Negotiation><Neuritic Plaques><Pathologic><Pathology><Pathway interactions><Patients><Personal Medical History><Personal Medical History Epidemiology><Population><Primary Senile Degenerative Dementia><Process><Protein Gene Products><Protein Isoforms><Recording of previous events><Research><Role><Sampling><Senile Plaques><Siblings><Sleep Apnea><Sleep Apnea Syndromes><Sleep Hypopnea><Sleep-Disordered Breathing><Source><Statistical Methods><Study models><Testing><Therapeutic Intervention><Training><Trees><Trisomy 21><a beta peptide><abeta><abeta production><adulthood><alzheimer risk><amyloid beta><amyloid beta plaque><amyloid beta production><amyloid beta synthesis><amyloid precursor protein><amyloid-b plaque><amyloid-b protein><autosomal dominant AD><autosomal dominant Alzheimer's disease><aβ plaques><beta amyloid fibril><bio-markers><biologic><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><boost longevity><cardiovascular disorder><causation><chromosome 21 trisomy><chromosome 21 trisomy syndrome><circulatory system><cognitive dysfunction><cognitive loss><computer based prediction><congenital acromicria syndrome><cored plaque><data sharing><demographics><design><designing><develop software><developing computer software><diffuse plaque><disease causation><down syndrome individuals><down syndrome patients><early detection><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><flexibility><flexible><foster longevity><histories><imaging><improve lifespan><improve longevity><improved><inclusion criteria><innovate><innovation><innovative><intellectual and developmental disability><intervention therapy><lifespan extension><limited intellectual functioning><machine based learning><mechanisms in AD><mechanisms in Alzheimer's disease><morbus Down><novel><overexpress><overexpression><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><patients with down syndrome><people with down syndrome><pre-clinical><preclinical><predictive modeling><primary degenerative dementia><prolong lifespan><prolong longevity><promote lifespan><promote longevity><pseudohypertrophic progressive muscular dystrophy><regression trees><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sleep-related breathing disorder><social role><software development><soluble amyloid precursor protein><statistic methods><support longevity><symptomatology><targeted agent><trisomy 21 syndrome>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jiebiao Wang

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 16/100

Active award

$223,754

FY 2026

Project Title

Heterogeneous genetics effects and mediation in Alzheimer's disease

Grant Number:

5R21AG087057-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

Project Summary Down syndrome (DS) is the most common genetic intellectual and developmental disability and has historically been associated with poor life expectancy. However, improvements in medical care have increased the lifespan of individuals with DS to above 60 years. Individuals with DS hav...

Research Terms

<21+ years old><A β-42><A β42><A-beta 42><A-beta42><AD biological marker><AD biomarker><AD dementia><AD pathology><AD pathway><AD related biomarker><AD risk><AD risk factor><AD-associated pathways><AD-related pathways><AD-specific pathways><APOE><Abeta synthesis><Abeta-42><Abeta42><Acceleration><Accounting><Adult><Adult Human><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease mechanism><Alzheimer pathway><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease Pathway><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's mechanism><Alzheimer's pathology><Alzheimer's precursor protein><Alzheimer's related biomarker><Alzheimer's related pathways><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Amyloid (Aβ) plaques><Amyloid A4 Protein Precursor><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Protein Precursor><Amyloid beta-42><Amyloid beta-Protein><Amyloid beta-Protein Precursor><Amyloid beta42><Amyloid β><Amyloid β production><Amyloid β synthesis><Amyloid β-42><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β-Protein Precursor><Amyloid β42><Amyloidβ-42><Amyloidβ42><Apo-E><ApoE protein><Apolipoprotein E><Aβ><Aβ production><Aβ synthesis><Aβ-42><Aβ42><Bayesian Analysis><Bayesian computation><Bayesian inference><Bayesian network analysis><Bayesian spatial analysis><Bayesian statistical analysis><Bayesian statistical inference><Bayesian statistics><Biological><Biological Markers><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Caring><Causality><Chromosome 21><Clinical><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Data><Data Set><Dementia><Deposit><Deposition><Disease><Disease Marker><Disease Progression><Disorder><Disturbance in cognition><Down Syndrome><Early Diagnosis><Etiology><Family><Family Characteristics><Family Health><Family Medical History><Family Medical History Epidemiology><Family health status><Family history of><Gene Proteins><Genes><Genetic><Genotype><Goals><Heart Vascular><Heterogeneity><History><Hypothyroidism><Image><Impaired cognition><Increase lifespan><Individual><Individuals with down syndrome><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Isoforms><Langdon Down syndrome><Life Expectancy><Link><Machine Learning><Mediating><Mediation><Medical><Medical History><Methodology><Methods><Modeling><Modification><Mongolism><Negotiating><Negotiation><Neuritic Plaques><Pathologic><Pathology><Pathway interactions><Patients><Personal Medical History><Personal Medical History Epidemiology><Population><Primary Senile Degenerative Dementia><Process><Protein Gene Products><Protein Isoforms><Recording of previous events><Research><Role><Sampling><Senile Plaques><Siblings><Sleep Apnea><Sleep Apnea Syndromes><Sleep Hypopnea><Sleep-Disordered Breathing><Source><Statistical Methods><Study models><Testing><Therapeutic Intervention><Training><Trees><Trisomy 21><a beta peptide><abeta><abeta production><adulthood><alzheimer risk><amyloid beta><amyloid beta plaque><amyloid beta production><amyloid beta synthesis><amyloid precursor protein><amyloid-b plaque><amyloid-b protein><autosomal dominant AD><autosomal dominant Alzheimer's disease><aβ plaques><beta amyloid fibril><bio-markers><biologic><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><boost longevity><cardiovascular disorder><causation><chromosome 21 trisomy><chromosome 21 trisomy syndrome><circulatory system><cognitive dysfunction><cognitive loss><computer based prediction><congenital acromicria syndrome><cored plaque><data sharing><demographics><design><designing><develop software><developing computer software><diffuse plaque><disease causation><down syndrome individuals><down syndrome patients><early detection><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><flexibility><flexible><foster longevity><histories><imaging><improve lifespan><improve longevity><improved><inclusion criteria><innovate><innovation><innovative><intellectual and developmental disability><intervention therapy><lifespan extension><limited intellectual functioning><machine based learning><mechanisms in AD><mechanisms in Alzheimer's disease><morbus Down><novel><overexpress><overexpression><pathway><pathways associated with AD><pathways associated with Alzheimer's><pathways contribute to Alzheimer's><pathways involved in Alzheimer disease><pathways that contribute to AD><pathways that drive AD><pathways underlying Alzheimer's><patients with down syndrome><people with down syndrome><pre-clinical><preclinical><predictive modeling><primary degenerative dementia><prolong lifespan><prolong longevity><promote lifespan><promote longevity><pseudohypertrophic progressive muscular dystrophy><regression trees><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><sleep-related breathing disorder><social role><software development><soluble amyloid precursor protein><statistic methods><support longevity><symptomatology><targeted agent><trisomy 21 syndrome>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

STEVEN F DOWDY

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 16/100

Active award

$199,375

FY 2026

Project Title

Treating Alzheimer's Disease with PMO RNA Therapeutics

Grant Number:

5R21NS140937-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

ABSTRACT Alzheimer's Disease (AD) is a devastatingly progressive, fatal neurodegenerative disease. With approximately 30 million patients affected worldwide, it is the most common form of dementia and is predicted to grow exponentially. The pathology of AD is driven by Amyloid Precursor Protein (APP...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Arianna LaCroix

PURDUE UNIVERSITY, WEST LAFAYETTE, IN

Exploratory lead · 16/100

Active award

$189,720

FY 2026

Project Title

Optimizing the assessment of auditory attention in aphasia

Grant Number:

5R21DC021481-03

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/5/2024

End Date:

12/31/2026

Project Abstract

ABSTRACT Aphasia is a disorder marked by impairments in language and cognition. There is substantial variability in how well people with aphasia (PWA) respond to treatment. This variability stems from aphasia treatment programs primarily focusing on language, which is problematic since experimental ...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Takese Tasseen McKenzie

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Exploratory lead · 16/100

Active award

$37,746

FY 2026

Project Title

Elucidating Novel Regulators of Microglial Phagocytosis in Alzheimer’s Disease

Grant Number:

5F99AG088439-02

Activity Code:

F99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

Project Summary Over 6 million Americans aged 65 and above currently suffer from Alzheimer's Disease (AD). This substantial prevalence among the elderly underscores aging as one of the most prominent risk factors contributing to the onset of AD. Microglia are cells that facilitate the clearance of c...

Research Terms

<1-Phosphatidylinositol 3-Kinase><AD brain><AD dementia><AD pathology><AD risk><AD risk factor><AD therapy><AD treatment><Aging><Agonist><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's therapy><Alzheimers Dementia><American><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Attenuated><Automobile Driving><Autopsy><Autoregulation><Aβ><Basal Transcription Factor><Basal transcription factor genes><Biology><Brain><Brain Nervous System><CNS Nervous System><Cause of Death><Cell Body><Cell Membrane Lipids><Cells><Central Nervous System><Characteristics><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Data><Degenerative Neurologic Disorders><Demyelinations><Development><Disease><Disease Progression><Disorder><Disturbance in cognition><Down-Regulation><Dysfunction><Elderly><Encephalon><Endosomes><Enzyme Gene><Enzymes><Foundations><Functional disorder><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Histopathology><Homeostasis><Hortega cell><Human><Impaired cognition><Impairment><Inflammatory><Intermediary Metabolism><Investigators><Knowledge><Laboratory Research><Light><Link><Lipids><Measures><Membrane><Membrane Lipids><Mentors><Mentorship><Metabolic Processes><Metabolism><Mice><Mice Mammals><Microglia><Modern Man><Molecular><Motor><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neuritic Plaques><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurofibrillary Tangles><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><PPAR-beta><PPAR-β><PPARbeta><PPARβ><Pathogenesis><Pathology><Phagocyte Bactericidal Dysfunction><Phagocytes><Phagocytic Cell><Phagocytosis><Phagosomes><Phase><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Photoradiation><Physiological Homeostasis><Physiopathology><Play><Population><Postdoc><Postdoctoral Fellow><Prevalence><Primary Senile Degenerative Dementia><Process><PtdINS3P><PtdIns 3-Kinase><Publishing><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><R-Series Research Projects><R01 Mechanism><R01 Program><RNA-Binding Proteins><Receptosomes><Regulation><Research><Research Associate><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Risk Factors><Role><Senile Plaques><Study models><Testing><Training><Transcription Factor Proto-Oncogene><Transcription factor genes><Transgenic Mice><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><United States><Work><a beta peptide><abeta><abeta deposition><advanced age><age associated><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age correlated><age dependent><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age linked><age related><age related neurodegeneration><age specific><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><aged><aging associated disease><aging associated disorders><aging associated neurodegeneration><aging associated neurodegenerative disease><aging related disease><aging related disorders><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><alzheimer risk><amebocyte><amyloid beta><amyloid beta deposition><amyloid beta plaque><amyloid β deposition><amyloid-b plaque><amyloid-b protein><attenuate><attenuates><aβ deposition><aβ plaques><beta amyloid fibril><brain cell><cognitive defects><cognitive dysfunction><cognitive loss><cored plaque><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><demyelinate><density><developmental><diffuse plaque><disability><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><driving><experiment><experimental research><experimental study><experiments><familial AD><familial Alzheimer><familial Alzheimer disease><field based data><field learning><field study><field test><geriatric><gitter 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View Full Project Details on NIH Reporter

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Zhen Yan

VA WESTERN NEW YORK HEALTHCARE SYSTEM, BUFFALO, NY

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

A Multifactorial Mechanism for Alzheimer's Disease

Grant Number:

5I01BX006357-02

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2024

End Date:

9/30/2028

Project Abstract

Project Summary There is a dramatic increase in the prevalence of dementia among veterans, because of the aging of the veteran population and a high prevalence of dementia risk factors among veterans. Alzheimer’s disease (AD) is the most predominant neurodegenerative disorder linked to dementia. Thi...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

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