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Found 228 principal investigators from 200 displayed projects for "stem cell" (2021–2026)

Note: 45,644 projects matched but only the first 200 were analyzed. Try narrowing your search with a more specific term or selecting "Project title only".

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36

High-opportunity leads

151

Likely hiring signals

33

Training-friendly awards

54

Average opportunity score

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Lei Ding

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,137,883
FY 2026

Project Title

Dynamics and plasticity of the hematopoietic stem cell niche

Grant Number:

1R35HL184177-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2033

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project summary/Abstract Hematopoiesis is a highly regulated process fueled by hematopoietic stem cells (HSCs) and progenitors in response to physiological and pathological changes throughout life. During development, the system quickly expands to provide increasing numbers of blood cells for the gr...

Research Terms

<Blood><Blood Cell Count><Blood Cell Number><Blood Cells><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Cell Body><Cells><Development><Disease><Disease Progression><Disorder><Goals><HSC niche><HSC regeneration><HSC self-renewal><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Image><Life><Liver><Metabolic><Molecular><Natural regeneration><Organ><Pathologic><Pathway interactions><Peripheral Blood Cell><Physiologic><Physiological><Process><Production><Regeneration><System><Therapeutic><Tissues><Work><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell niche><blood stem cell regeneration><blood stem cell self-renewal><blood treatment><blood-forming stem cell><developmental><experiment><experimental research><experimental study><experiments><hematopoietic hierarchy><hematopoietic progenitor><hematopoietic progenitor cell self-renewal><hematopoietic progenitor niche><hematopoietic stem cell niche><hematopoietic stem cell regeneration><hematopoietic stem cell self-renewal><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><hepatic body system><hepatic organ system><imaging><mouse model><murine model><novel><pathway><regenerate><regeneration of blood stem cells><response><self - renewal in hematopoietic stem cells><transcriptomics>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Cambrian Yangshao Liu

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$819,234
FY 2026

Project Title

Stem Cell Dynamics in Colonic Epithelial Repair

Grant Number:

2R01DK108648-07A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2016

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Colonic epithelial wound healing is the primary therapeutic endpoint for inflammatory bowel disease (IBD), but a fundamental and unified understanding of wound healing mechanisms remains elusive. In the initial cycle of funding for this project, we developed and leveraged a three-dim...

Research Terms

<3-D><3-D Imaging><3-Dimensional><3D><3D imaging><Acute><Address><Agreement><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Apical><Basal Cell><Behavior><Bioinformatics><Biology><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Censuses><Clonal Expansion><Colitis><Colon><Colon Injury><Colonic inflammation><Cues><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Data><Detection><Epithelial Cells><Epithelium><Evolution><Funding><Future><GI Stem cell><Genes><Global Change><Goals><Health><Human><IFN><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Injury><Interferons><Intracellular Communication and Signaling><Isoforms><Knowledge><Licensing><Lineage Tracing><Link><Mediating><Messenger RNA><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Natural regeneration><Non-Polyadenylated RNA><Outcome><Pathway interactions><Patients><Pattern><Population><Post-Transcriptional RNA Modification><Post-Transcriptional RNA Processing><Process><Progenitor Cells><Proliferating><Protein Isoforms><Publishing><RNA><RNA Gene Products><RNA Splicing><Regeneration><Regulation><Relaxation><Reserve Stem Cell><Ribonucleic Acid><Role><Signal Transduction><Signal Transduction Systems><Signaling><Small Intestines><Specific qualifier value><Specified><Spliceosomes><Splicing><Stereotyping><Testing><Therapeutic><Three-Dimensional Imaging><Tissue imaging><Transcript><Ulcerated Colitis><Ulcerative Colitis><Upregulation><Wound Repair><biological signal transduction><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><colitis mouse model><colitis murine model><colitis-induced dysbiosis><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><epithelial repair><epithelial wound><experiment><experimental research><experimental study><experiments><fetal><gastrointestinal stem cell><gut progenitor><gut stem cell><healing><imaging><inflamed colon><inflammatory disease of the intestine><inflammatory disorder of the intestine><injured><injuries><interest><intestinal autoinflammation><intestinal progenitor><intestinal stem cells><mRNA><molecular biomarker><molecular marker><mouse colitis><mouse model><murine colitis><murine model><novel><pathway><posttranscriptional><primitive cell><progenitor cell function><progenitor cell markers><progenitor cell pool><progenitor cell population><progenitor function><progenitor markers><progenitor pool><progenitor population><progenitor stem cell markers><programs><quantitative imaging><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration function><regenerative><regenerative cell><regenerative function><regenerative functionality><repair><repaired><reserve progenitor><reserve stem and progenitor cell><segregation><small bowel><social role><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor function><stem cell biomarkers><stem cell function><stem cell markers><stem cell pool><stem cell population><stem cells><therapeutic target><three dimensional><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptome profiling><transcriptomic profiling><transcriptomics><translational opportunities><translational potential><wound healing><wound recovery><wound resolution>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

D Brent Polk

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$819,234
FY 2026

Project Title

Stem Cell Dynamics in Colonic Epithelial Repair

Grant Number:

2R01DK108648-07A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2016

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Colonic epithelial wound healing is the primary therapeutic endpoint for inflammatory bowel disease (IBD), but a fundamental and unified understanding of wound healing mechanisms remains elusive. In the initial cycle of funding for this project, we developed and leveraged a three-dim...

Research Terms

<3-D><3-D Imaging><3-Dimensional><3D><3D imaging><Acute><Address><Agreement><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Apical><Basal Cell><Behavior><Bioinformatics><Biology><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Censuses><Clonal Expansion><Colitis><Colon><Colon Injury><Colonic inflammation><Cues><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Data><Detection><Epithelial Cells><Epithelium><Evolution><Funding><Future><GI Stem cell><Genes><Global Change><Goals><Health><Human><IFN><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Injury><Interferons><Intracellular Communication and Signaling><Isoforms><Knowledge><Licensing><Lineage Tracing><Link><Mediating><Messenger RNA><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Natural regeneration><Non-Polyadenylated RNA><Outcome><Pathway interactions><Patients><Pattern><Population><Post-Transcriptional RNA Modification><Post-Transcriptional RNA Processing><Process><Progenitor Cells><Proliferating><Protein Isoforms><Publishing><RNA><RNA Gene Products><RNA Splicing><Regeneration><Regulation><Relaxation><Reserve Stem Cell><Ribonucleic Acid><Role><Signal Transduction><Signal Transduction Systems><Signaling><Small Intestines><Specific qualifier value><Specified><Spliceosomes><Splicing><Stereotyping><Testing><Therapeutic><Three-Dimensional Imaging><Tissue imaging><Transcript><Ulcerated Colitis><Ulcerative Colitis><Upregulation><Wound Repair><biological signal transduction><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><colitis mouse model><colitis murine model><colitis-induced dysbiosis><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><epithelial repair><epithelial wound><experiment><experimental research><experimental study><experiments><fetal><gastrointestinal stem cell><gut progenitor><gut stem cell><healing><imaging><inflamed colon><inflammatory disease of the intestine><inflammatory disorder of the intestine><injured><injuries><interest><intestinal autoinflammation><intestinal progenitor><intestinal stem cells><mRNA><molecular biomarker><molecular marker><mouse colitis><mouse model><murine colitis><murine model><novel><pathway><posttranscriptional><primitive cell><progenitor cell function><progenitor cell markers><progenitor cell pool><progenitor cell population><progenitor function><progenitor markers><progenitor pool><progenitor population><progenitor stem cell markers><programs><quantitative imaging><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration function><regenerative><regenerative cell><regenerative function><regenerative functionality><repair><repaired><reserve progenitor><reserve stem and progenitor cell><segregation><small bowel><social role><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor function><stem cell biomarkers><stem cell function><stem cell markers><stem cell pool><stem cell population><stem cells><therapeutic target><three dimensional><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptome profiling><transcriptomic profiling><transcriptomics><translational opportunities><translational potential><wound healing><wound recovery><wound resolution>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

GRIGORI N ENIKOLOPOV

STATE UNIVERSITY NEW YORK STONY BROOK, STONY BROOK, NY

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$775,592
FY 2026

Project Title

Endogenous barcoding to determine complex dynamics of adult neurogenesis in aging and Alzheimer's disease

Grant Number:

5R01AG076937-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT New neurons in the adult human and animal hippocampus have been implicated in several cognitive functions. These functions are profoundly impaired by the loss or insufficient production of new neurons. Neurons are produced after a prolonged series of transitions including the activation, p...

Research Terms

<21+ years old><AD dementia><AD model><AD pathology><Acceleration><Address><Adult><Adult Human><Adverse effects><Aging><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's pathology><Alzheimers Dementia><Ammon Horn><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Animals><Anticonvulsant Agent><Anticonvulsant Drugs><Anticonvulsants><Anticonvulsive Agents><Anticonvulsive Drugs><Aβ><Bar Codes><Birth><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Cell Body><Cell Differentiation><Cell Differentiation process><Cells><Clinical Treatment Moab><Clonal Expansion><Clonality><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complement><Complement Proteins><Complex><Cornu Ammonis><DNA><DNA Recombination><Deoxyribonucleic Acid><Development><Disease><Disorder><Disturbance in cognition><Drug usage><Drugs><EAA Antagonists><Encephalon><Encephalon Diseases><Excitatory Amino Acid Antagonists><Expression Signature><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profile><Gene Expression Profiling><Genes><Genetic Recombination><Glutamate Antagonists><Glutamate Receptor Antagonists><Goals><Hippocampus><Human><Impaired cognition><Impairment><Individual><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Knowledge><Label><Levetiracetam><Life Cycle><Life Cycle Stages><Link><Maintenance><Malignant><Malignant - descriptor><Medication><Memantin><Memantine><Methods><Mice><Mice Mammals><Modality><Modeling><Modern Man><Monoclonal Antibodies><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neural Stem Cell><Neurocyte><Neurons><Non-Polyadenylated RNA><Outcome><Parturition><Pharmaceutical Preparations><Physical activity><Primary Senile Degenerative Dementia><Production><Progenitor Cells><Proliferating><RNA><RNA Gene Products><Recombination><Regulation><Reporter><Resolution><Ribonucleic Acid><Running><Scheme><Series><System><Techniques><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><a beta peptide><abeta><adult animal><adult neurogenesis><adulthood><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age related alterations><age related changes><age specific alterations><age specific changes><aged brain><aging associated><aging associated alterations><aging associated changes><aging associated disease><aging associated disorders><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related><aging related alterations><aging related changes><aging related disease><aging related disorders><aging specific alterations><aging specific changes><alterations with age><alzheimer model><amyloid beta><amyloid-b protein><analyze gene expression><barcode><beta amyloid fibril><cellular differentiation><changes with age><cognitive dysfunction><cognitive function><cognitive loss><cohort><combinatorial><complementation><developmental><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><drug use><drug/agent><gene expression analysis><gene expression assay><gene expression pattern><gene expression signature><global gene expression><global transcription profile><hippocampal><instrument><life course><life span><lifespan><mAbs><mature animal><model of animal><monoclonal Abs><mouse genome><mouse model><murine model><natural aging><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopment><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new approaches><normal aging><normative aging><novel approaches><novel strategies><novel strategy><old age><primary degenerative dementia><progenitor and neural stem cells><progenitor cell division><progenitor cell renewal><progenitor division><progenitor renewal><resolutions><seizure drug><seizure medication><senile dementia of the Alzheimer type><single cell analysis><soluble amyloid precursor protein><stem and progenitor cell division><stem and progenitor cell renewal><stem cell depletion><stem cell division><stem cell exhaustion><stem cell fatigue><stem cell renewal><stem cells><tool><transcriptional profile><transcriptional profiling><transcriptional signature><transcriptome><transcriptomics>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

HANS-PETER KIEM

FRED HUTCHINSON CANCER CENTER, SEATTLE, WA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$756,008
FY 2026

Project Title

CD90-targeted nanoparticles for in vivo hematopoietic stem cell gene therapy

Grant Number:

5R01HL173365-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Patients with genetic blood diseases and disorders are commonly treated with blood (hematopoietic) stem cell (HSC) transplants from healthy, human leukocyte antigen (HLA)-matched sibling donors. Unfortunately, for most patients, there is no HLA-identical sibling donor availa...

Research Terms

<Active Follow-up><Affect><Animal Model><Animal Models and Related Studies><Antibodies><Apheresis><Autopsy><BM Stem Cell><BM derived progenitor><BM progenitor><BM- derived Stem Cells><Biodistribution><Blood><Blood Component Removal><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Blood leukocyte><Bone Marrow Grafting><Bone Marrow Stem Cell><Bone Marrow Transplant><Bone Marrow Transplantation><Bone Marrow progenitor><CD34><CD34 gene><CRISPR><CRISPR/Cas system><Cell Body><Cell Compartmentation><Cell Compartmentations><Cell Line><CellLine><Cells><Circulation><Clustered Regularly Interspaced Short Palindromic Repeats><Collaborations><DNA Double Strand Break><DNA Therapy><Disease><Disorder><Dose><Encapsulated><Engraftment><Environment><Fetal Hb><Fetal Hemoglobin><Formulation><Foundations><Freeze Drying><Freeze Dryings><Gene Frequency><Gene Modified><Gene Therapy Agent><Gene Transfer><Gene Transfer Clinical><Genes><Genetic><Genetic Diseases><Genetic Intervention><Globin><Goals><GvHD><HL-A Antigens><HLA Antigens><HPCA1><HSC transplantation><HbF><Hemapheresis><Hematologic Body System><Hematologic Diseases><Hematologic Organ System><Hematological Disease><Hematological Disorder><Hematopoietic><Hematopoietic Body System><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic System><Hematopoietic stem cells><Hemoglobin F><Homologous Wasting Disease><Human><Human Leukocyte Antigens><Immunodeficient Mouse><Infrastructure><Injections><Institution><Knock-out><Knockout><LMIC><Lentivirinae><Lentivirus><Leukocyte Antigens><Leukocytes><Leukocytes Reticuloendothelial System><Life><Longitudinal Studies><Longitudinal Surveys><Luciferase Immunologic><Luciferases><Lyophilization><Malignant><Malignant - descriptor><Marrow><Marrow Transplantation><Marrow leukocyte><Mediating><Messenger RNA><Mice><Mice Mammals><Modeling><Modern Man><Modification><Monitor><Murine><Mus><NHP models><Patients><Phenotype><Pheresis><Polymers><Population><Population Heterogeneity><Process><Progenitor Cell Transplantation><Property><Proteins><Reagent><Recovery><Reporting><Route><Runt Disease><Safety><Siblings><Side><Specificity><Stem Cell Transplantation><Stem cell transplant><Strains Cell Lines><Surface><Therapeutic><Time><White Blood Cells><White Cell><Work><active followup><allelic frequency><alternative treatment><base editor><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell transplantation><blood treatment><blood-forming stem cell><bone marrow derived progenitor><bone marrow derived stem cells><bone marrow stromal cell><bone marrow stromal stem cell><cell type><clinical translation><clinically translatable><cost><cultured cell line><design><designing><diverse populations><fetal form of hemoglobin><fetal globin><follow up><follow-up><followed up><followup><gene modification><gene repair therapy><gene therapeutics><gene therapy><gene-based therapeutic><gene-based therapeutics><gene-based therapy><gene-based treatment><gene-directed therapy><gene-targeted therapy><gene-targeted treatment><genes therapeutic><genes therapeutics><genetic approach><genetic condition><genetic disorder><genetic strategy><genetic therapy><genetically modified><genomic therapy><graft versus host disease><graft vs host disease><graft vs. host disease><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><heterogeneous population><humanized mice><humanized mouse><improved><in vitro testing><in vivo><lipid based nanoparticle><lipid nanoparticle><long-term study><longitudinal outcome studies><longitudinal research study><low and middle-income countries><mRNA><model of animal><mouse model><murine model><nano particle><nano-sized particle><nanoparticle><nanosized particle><necropsy><next generation><non-human primate><nonhuman primate><nonhuman primate models><novel><nuclease><p-Globin><polymer><polymeric><population diversity><portability><postmortem><pre-clinical><preclinical><progenitor cell gene><progenitor gene><progenitor transplantation><safety assessment><scale up><side effect><site targeted delivery><stem and progenitor cell transplantations><stem cell gene therapy><stem cell genes><synergism><targeted delivery><testing uptake><therapeutic gene><therapeutic target><tool><treatment strategy><white blood cell><white blood corpuscle>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Cristiana Cairo

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$753,784
FY 2026

Project Title

Deciphering hematopoietic stem cell defects in HIV exposed, uninfected infants born to ART-treated mothers

Grant Number:

5R01AI183982-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/8/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: Intensive research of the past few decades demonstrated that Human Immunodeficiency Virus (HIV)- infected individuals develop severe hematopathologies, including anemia, thrombocytopenia, pancytopenia, and bone marrow failure. Even though a great deal of information is available on ...

Research Terms

<0-11 years old><0-4 weeks old><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Affect><Airway infections><Anemia><Anti-HIV Positivity><Basal Transcription Factor><Basal transcription factor genes><Biochemical><Biophysics><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Blood monocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone marrow failure><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Signaling><Cells><Cellular Immune Function><Cellular biology><Child><Child Youth><Children (0-21)><Chronic><Cord Blood><Cytometry><Cytotoxic cell><Data><Death Rate><Defect><Dendritic Cells><Differentiation in cell culture><Engraftment><Event><Exhibits><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Frequencies><General Transcription Factor Gene><General Transcription Factors><Genetic><Goals><HIV><HIV Infections><HIV Positive><HIV Positivity><HIV Seroconversion><HIV Seropositivity><HIV antibody positive><HIV in patients><HIV individuals><HIV infected individuals><HIV infected persons><HIV patient><HIV people><HIV positive individuals><HIV positive patient><HIV positive people><HIV viral infection><HIV virus infection><HIV+><HIV-1><HIV-1 infection><HIV-I><HIV-exposed uninfected infant><HIV1><HTLV-III Seroconversion><HTLV-III Seropositivity><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopathology><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterograft><Heterologous Transplantation><Human><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Human immunodeficiency virus infected patients><Human immunodeficiency virus positive patients><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immunes><Immunity><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Impairment><In Vitro><In vitro cell differentiation><Individual><Infant><Infection><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Inflammation><Inflammation Mediators><Inflammatory><Intracellular Communication and Signaling><Investigation><K lymphocyte><Knowledge><LAV-HTLV-III><Life><Link><Lymphadenopathy-Associated Virus><Macrophage><Maintenance><Marrow monocyte><Maternal Exposure><Modern Man><Molecular><Mononuclear><Morbidity><Mothers><Myelogenous><Myeloid><Myeloid Cells><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><Mφ><NK Cells><Natural Killer Cells><Newborn Infant><Newborns><Opportunistic Infections><Outcome><PLWH><PWH><Pancytopenia><Pathway interactions><Patients living with HIV><Patients suffering from HIV><Peripheral><Physiologic><Physiological><Predisposition><Proteomics><Research><Respiratory Infections><Respiratory Tract Infections><Signal Transduction><Signal Transduction Systems><Signaling><Source><Susceptibility><T-Cells><T-Lymphocyte><T8 Cells><T8 Lymphocytes><Testing><Therapeutic><Thrombocytopenia><Thrombopenia><Transcription Factor Proto-Oncogene><Transcription factor genes><Umbilical Cord Blood><Veiled Cells><Virus><Virus-HIV><Xenograft><Xenograft procedure><Xenotransplantation><antiretroviral therapy><antiretroviral treatment><bacterial sepsis><biological signal transduction><biophysical foundation><biophysical principles><biophysical sciences><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood-forming stem cell><bone progenitor><bone stem cell><cell biology><clinical relevance><clinically relevant><cytokine><design><designing><differentiation in culture><differentiation in vitro><effective therapy><effective treatment><exposed in utero><fetal cord blood><fetal exposure><flow cytophotometry><hematopoietic differentiation><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><high risk><host response><human immunodeficiency virus infection><human immunodeficiency virus patient><humanized mice><humanized mouse><immune function><immune system response><immunoresponse><in utero><in utero exposure><in vitro cellular differentiation><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><inflammatory mediator><insight><intra-uterine environmental exposure><intrauterine environmental exposure><kids><lymphocyte precursor><lymphocyte progenitor><lymphocyte stem cell><lymphoid precursor><lymphoid progenitors><lymphoid stem cell><microbial><monocyte><mortality><mortality rate><mouse model><murine model><myeloid precursor><myeloid stem and progenitor cell><newborn child><newborn children><novel><pathway><patient infected with HIV><patient with HIV><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><prenatal exposure><prenatally exposed><progenitor cell function><progenitor cell maintenance><progenitor function><progenitor maintenance><self-renew><self-renewal><stem and progenitor cell function><stem and progenitor function><stem cell function><stem cell maintenance><thymus derived lymphocyte><transcription factor><xeno-transplant><xeno-transplantation><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Chozha Vendan Rathinam

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$753,784
FY 2026

Project Title

Deciphering hematopoietic stem cell defects in HIV exposed, uninfected infants born to ART-treated mothers

Grant Number:

5R01AI183982-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/8/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: Intensive research of the past few decades demonstrated that Human Immunodeficiency Virus (HIV)- infected individuals develop severe hematopathologies, including anemia, thrombocytopenia, pancytopenia, and bone marrow failure. Even though a great deal of information is available on ...

Research Terms

<0-11 years old><0-4 weeks old><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Affect><Airway infections><Anemia><Anti-HIV Positivity><Basal Transcription Factor><Basal transcription factor genes><Biochemical><Biophysics><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Blood monocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone marrow failure><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Signaling><Cells><Cellular Immune Function><Cellular biology><Child><Child Youth><Children (0-21)><Chronic><Cord Blood><Cytometry><Cytotoxic cell><Data><Death Rate><Defect><Dendritic Cells><Differentiation in cell culture><Engraftment><Event><Exhibits><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Frequencies><General Transcription Factor Gene><General Transcription Factors><Genetic><Goals><HIV><HIV Infections><HIV Positive><HIV Positivity><HIV Seroconversion><HIV Seropositivity><HIV antibody positive><HIV in patients><HIV individuals><HIV infected individuals><HIV infected persons><HIV patient><HIV people><HIV positive individuals><HIV positive patient><HIV positive people><HIV viral infection><HIV virus infection><HIV+><HIV-1><HIV-1 infection><HIV-I><HIV-exposed uninfected infant><HIV1><HTLV-III Seroconversion><HTLV-III Seropositivity><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopathology><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterograft><Heterologous Transplantation><Human><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Human immunodeficiency virus infected patients><Human immunodeficiency virus positive patients><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immunes><Immunity><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Impairment><In Vitro><In vitro cell differentiation><Individual><Infant><Infection><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Inflammation><Inflammation Mediators><Inflammatory><Intracellular Communication and Signaling><Investigation><K lymphocyte><Knowledge><LAV-HTLV-III><Life><Link><Lymphadenopathy-Associated Virus><Macrophage><Maintenance><Marrow monocyte><Maternal Exposure><Modern Man><Molecular><Mononuclear><Morbidity><Mothers><Myelogenous><Myeloid><Myeloid Cells><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><Mφ><NK Cells><Natural Killer Cells><Newborn Infant><Newborns><Opportunistic Infections><Outcome><PLWH><PWH><Pancytopenia><Pathway interactions><Patients living with HIV><Patients suffering from HIV><Peripheral><Physiologic><Physiological><Predisposition><Proteomics><Research><Respiratory Infections><Respiratory Tract Infections><Signal Transduction><Signal Transduction Systems><Signaling><Source><Susceptibility><T-Cells><T-Lymphocyte><T8 Cells><T8 Lymphocytes><Testing><Therapeutic><Thrombocytopenia><Thrombopenia><Transcription Factor Proto-Oncogene><Transcription factor genes><Umbilical Cord Blood><Veiled Cells><Virus><Virus-HIV><Xenograft><Xenograft procedure><Xenotransplantation><antiretroviral therapy><antiretroviral treatment><bacterial sepsis><biological signal transduction><biophysical foundation><biophysical principles><biophysical sciences><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood-forming stem cell><bone progenitor><bone stem cell><cell biology><clinical relevance><clinically relevant><cytokine><design><designing><differentiation in culture><differentiation in vitro><effective therapy><effective treatment><exposed in utero><fetal cord blood><fetal exposure><flow cytophotometry><hematopoietic differentiation><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><high risk><host response><human immunodeficiency virus infection><human immunodeficiency virus patient><humanized mice><humanized mouse><immune function><immune system response><immunoresponse><in utero><in utero exposure><in vitro cellular differentiation><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><inflammatory mediator><insight><intra-uterine environmental exposure><intrauterine environmental exposure><kids><lymphocyte precursor><lymphocyte progenitor><lymphocyte stem cell><lymphoid precursor><lymphoid progenitors><lymphoid stem cell><microbial><monocyte><mortality><mortality rate><mouse model><murine model><myeloid precursor><myeloid stem and progenitor cell><newborn child><newborn children><novel><pathway><patient infected with HIV><patient with HIV><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><prenatal exposure><prenatally exposed><progenitor cell function><progenitor cell maintenance><progenitor function><progenitor maintenance><self-renew><self-renewal><stem and progenitor cell function><stem and progenitor function><stem cell function><stem cell maintenance><thymus derived lymphocyte><transcription factor><xeno-transplant><xeno-transplantation><youngster>
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Smita Yadav

UNIVERSITY OF WASHINGTON, SEATTLE, WA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$727,411
FY 2026

Project Title

Kinase Dysfunction in Autism and Neurodevelopmental Disorders

Grant Number:

5R01MH130336-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Kinase signaling exquisitely orchestrates each step of neuronal development, beginning at neurogenesis to neuronal integration into functional synaptic networks. Through their highly specific substrate phosphorylation, protein kinases regulate neuronal growth, activity and their plasticity...

Research Terms

<3-D modeling><3D modeling><ASD><ATP-protein phosphotransferase><Amino Acids><Ammon Horn><Assay><Autism><Autistic Disorder><Binding><Bioassay><Biochemical><Biochemistry><Biologic Models><Biological><Biological Assay><Biological Chemistry><Biological Models><Biology><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Causality><Cell Communication and Signaling><Cell Signaling><Cell membrane><Cerebral cortex><Cornu Ammonis><Cytoplasmic Membrane><DNA mutation><Data><Development><Disease><Disorder><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Etiology><Functional disorder><Generalized Growth><Genes><Genetic Change><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic defect><Genetic mutation><Growth><Hereditary><Hippocampus><Human><Human Engineering><In Vitro><Induced pluripotent stem cell derived neurons><Infantile Autism><Inherited><Inositide Phospholipids><Inositol Phosphoglycerides><Inositol Phospholipids><Intracellular Communication and Signaling><Investigation><Kanner's Syndrome><Kinase Family Gene><Kinases><Lead><Lipid Binding><Liposomal><Liposomes><Macrocephaly><Macromolecular Structure><Mediating><Megacephaly><Megalocephaly><Membrane><Model System><Modeling><Modern Man><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Molecular Structure><Morphology><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neurons><Neuropathogenesis><Neurophysiology / Electrophysiology><Organoids><Pathogenesis><Pathway interactions><Pb element><Phosphatides><Phosphatidyl Inositol><Phosphatidylinositols><Phosphoinositides><Phospholipids><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Physiopathology><Plasma Membrane><Property><Protein Kinase><Protein Phosphorylation><Protein Truncation><Protein-Serine Kinase><Protein-Serine-Threonine Kinases><Protein-Threonine Kinase><Proteins><Proteomics><PtdIns><Recombinant DNA Technology><Research Proposals><Role><Serine Kinase><Serine-Threonine Kinases><Serine/Threonine Protein Kinase Gene><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single Crystal Diffraction><Spinal Column><Spine><Synapses><Synaptic><Testing><Threonine Kinase><Tissue Growth><Transphosphorylases><Vertebral column><X Ray Crystallographies><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray/Neutron Crystallography><Xray Crystallography><aminoacid><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><backbone><biologic><biological signal transduction><causation><chemical genetics><comparative><conformation><conformational><conformational state><conformationally><conformations><developmental><disease causation><electrophysiological><excitatory neuron><experiment><experimental research><experimental study><experiments><genetically engineered><genome mutation><glycogen synthase a kinase><heavy metal Pb><heavy metal lead><hiPSC><hippocampal><human disease><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human progenitor cell derived><human stem cell-derived><hydroxyalkyl protein kinase><iPS neurons><iPSC derived-neurons><iPSC technology><induced human pluripotent stem cells><induced pluripotent stem cell neurons><induced pluripotent stem cell technology><inhibitor><innovate><innovation><innovative><lipid bound><membrane structure><migration><mutant><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopmental disease><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuron development><neuron progenitors><neuronal><neuronal development><neuronal growth><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><neuropathologic><neuropathological><neuropathology><neuroprogenitor><ontogeny><pathophysiology><pathway><phospho-proteomics><phosphoproteomics><phosphorylase b kinase kinase><plasmalemma><progenitor and neural stem cells><progenitor cell model><progenitor model><reconstitute><reconstitution><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stem cell technology><structural biology><synapse><three-dimensional modeling>
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Wenjun Guo

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$680,121
FY 2026

Project Title

Understanding mechanisms of immunoevasion by precancer stem cells for breast cancer interception

Grant Number:

1R01CA306893-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Basal-like breast cancer (BLBC) is an aggressive cancer subtype that disproportionally affects younger women and women of African ancestry, contributing to cancer disparity. Additionally, women with BRCA1 germline mutations have an extremely high risk of developing BLBC. BLBC precancer tends...

Research Terms

<Affect><African Females><African Women><African ancestry><African descent><Antioncogene Protein p53><B7 family member, H4><B7 superfamily member 1><B7-H4><B7H4><B7S1><B7X><BRCA1><BRCA1 Gene Product><BRCA1 Mutation><BRCA1 Protein><BRCA1 gene><BRCA1 gene mutation><Basal Transcription Factor><Basal transcription factor genes><Bowel Cancer><Breast><Breast Cancer><Breast Cancer 1 Gene><Breast Cancer 1 Gene Product><Breast Cancer Cell><Breast Cancer Prevention><Breast Cancer Type 1 Susceptibility Gene><Breast Cancer Type 1 Susceptibility Protein><Breast Tissue><Breast-Ovarian Cancer Protein><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><CXCL1><CXCL1 gene><CXCL2><CXCL2 gene><Cancers><Cell Body><Cells><Cellular Tumor Antigen P53><Chemokine, CXC Motif, Ligand 2><Chemotactic Cytokines><Combined Modality Therapy><DCIS><DNA mutation><Down-Regulation><Ductal Breast Carcinoma In Situ><Ductal Carcinoma In Situ><Early Onset Gene Breast Cancer 1><Early Onset Protein Breast Cancer 1><Embryo><Embryonic><FLJ22418><Frequencies><GRO Protein, Beta><GRO1><GRO2><GRO2 Oncogene><GROA><GROb><GROβ><General Transcription Factor Gene><General Transcription Factors><Generations><Genetic><Genetic Change><Genetic defect><Genetic mutation><Germ Lines><Germ-Line Mutation><Goals><Hereditary><Hereditary Breast Cancer 1><Hereditary Mutation><Homologous Chemotactic Cytokines><Human><Immune><Immune Surveillance><Immune mediated therapy><Immune response><Immunes><Immunochemical Immunologic><Immunologic><Immunologic Surveillance><Immunological><Immunologically><Immunologically Directed Therapy><Immunologics><Immunoprevention><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunosurveillance><Immunotherapy><Incidence><Infiltration><Inherited><Intercept><Intercrines><Interdisciplinary Research><Interdisciplinary Study><Intestinal Cancer><Intraductal Carcinoma><Intraductal Carcinoma of the Breast><Knock-out><Knockout><LYT3><Lesion><MGF Stem Cell Factor><MGSA><MIP-2A><MIP2-alpha><MIP2A><MIP2α><Malignant><Malignant - descriptor><Malignant Breast Neoplasm><Malignant Intestinal Neoplasm><Malignant Intestinal Tumor><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Skin Neoplasm><Malignant Tumor><Malignant neoplasm of pancreas><Mammary Gland Parenchyma><Mammary Gland Tissue><Mast Cell Growth Factor><Mediating><Modeling><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Multidisciplinary Collaboration><Multidisciplinary Research><Multimodal Therapy><Multimodal Treatment><Mutation><Myeloid-derived suppressor cells><Non-Infiltrating Ductal Breast Adenocarcinoma><Non-Infiltrating Ductal Carcinoma of the Breast><Non-Infiltrating Intraductal Adenocarcinoma><Non-Infiltrating Intraductal Breast Adenocarcinoma><Non-Invasive Ductal Breast Adenocarcinoma><Non-Invasive Ductal Carcinoma of the Breast><Non-Invasive Intraductal Breast Adenocarcinoma><Noninfiltrating Intraductal Carcinoma><Oncogenic><Oncoprotein p53><Outcome><P53><Pancreas Cancer><Pancreatic Cancer><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phosphoprotein P53><Phosphoprotein pp53><Preventative strategy><Prevention strategy><Preventive strategy><Process><Progenitor Cells><Protein TP53><RNF53><Research><Research Resources><Resources><Risk><Role><SCYB1><SCYB2><SIS cytokines><Skin Cancer><Small Inducible Cytokine Subfamily B, Member 2><Steel Factor><Stem Cell Factor><T cell infiltration><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><T8 Cells><T8 Lymphocytes><TP53><TP53 gene><TRP53><Testing><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Protein p53><Tumor Protein p53 Gene><Tumor Suppressor Proteins><Upregulation><V-set domain containing T cell activation inhibitor 1><VTCN1><VTCN1 gene><Woman><aggressive breast cancer><brca 1 gene><breast epithelium><breast progenitor><breast progenitor cell><breast stem cell><breast tumor cell><breast tumorigenesis><c-kit Ligand><cancer disparity><cancer health disparity><cancer immunology><cancer prevention><cancer progression><cancer sub-types><cancer subtypes><cancer type><cancer-related health disparity><cancer/testis antigen><cell type><chemoattractant cytokine><chemokine><combination therapy><combined modality treatment><combined treatment><determine efficacy><disparity in cancer><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><evaluate vaccines><examine efficacy><genome mutation><germ-line defect><germline variant><high risk><host response><immune check point><immune checkpoint><immune clearance><immune elimination><immune microenvironment><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immunecheckpoint><immuno therapy><immunogenic><immunogenicity><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive microenvironment><immunosuppressive myeloid cells><immunosuppressive response><immunosuppressive tumor microenvironment><improved outcome><innovate><innovation><innovative><intestine cancer><kit Ligand><macrophage inflammatory protein 2><malignancy><malignant breast tumor><malignant intestine neoplasm><malignant intestine tumor><malignant skin tumor><mammary><mammary cancer prevention><mammary epithelium><mammary gland progenitor><mammary gland stem cells><mammary progenitor><mammary stem cells><mammary tumor prevention><molecular profile><molecular signature><mouse model><multi-modal therapy><multi-modal treatment><multipotency><multipotent><multipotent cell><murine model><mutant><mutation carrier><myeloid suppressor cells><myeloid-derived suppressive cells><neoplasm immunology><neoplasm progression><neoplasm/cancer><neoplastic progression><novel><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pancreatic malignancy><pathway><patient oriented outcomes><precancer><precancerous><premalignant><prevent breast cancer><progenitor biology><progenitor cell biology><progenitor-like cell><protein p53><recruit><social role><stem and progenitor biology><stem cell biology><stem cells><stem-like cell><suppressive myeloid cells><thymus derived lymphocyte><tool><transcription factor><tumor><tumor immune microenvironment><tumor immunology><tumor progression><tumor suppressor><tumor-immune system interactions><vaccine evaluation><vaccine screening><vaccine testing><young woman><β-GRO protein>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Xingxing Zang

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$680,121
FY 2026

Project Title

Understanding mechanisms of immunoevasion by precancer stem cells for breast cancer interception

Grant Number:

1R01CA306893-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Basal-like breast cancer (BLBC) is an aggressive cancer subtype that disproportionally affects younger women and women of African ancestry, contributing to cancer disparity. Additionally, women with BRCA1 germline mutations have an extremely high risk of developing BLBC. BLBC precancer tends...

Research Terms

<Affect><African Females><African Women><African ancestry><African descent><Antioncogene Protein p53><B7 family member, H4><B7 superfamily member 1><B7-H4><B7H4><B7S1><B7X><BRCA1><BRCA1 Gene Product><BRCA1 Mutation><BRCA1 Protein><BRCA1 gene><BRCA1 gene mutation><Basal Transcription Factor><Basal transcription factor genes><Bowel Cancer><Breast><Breast Cancer><Breast Cancer 1 Gene><Breast Cancer 1 Gene Product><Breast Cancer Cell><Breast Cancer Prevention><Breast Cancer Type 1 Susceptibility Gene><Breast Cancer Type 1 Susceptibility Protein><Breast Tissue><Breast-Ovarian Cancer Protein><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><CXCL1><CXCL1 gene><CXCL2><CXCL2 gene><Cancers><Cell Body><Cells><Cellular Tumor Antigen P53><Chemokine, CXC Motif, Ligand 2><Chemotactic Cytokines><Combined Modality Therapy><DCIS><DNA mutation><Down-Regulation><Ductal Breast Carcinoma In Situ><Ductal Carcinoma In Situ><Early Onset Gene Breast Cancer 1><Early Onset Protein Breast Cancer 1><Embryo><Embryonic><FLJ22418><Frequencies><GRO Protein, Beta><GRO1><GRO2><GRO2 Oncogene><GROA><GROb><GROβ><General Transcription Factor Gene><General Transcription Factors><Generations><Genetic><Genetic Change><Genetic defect><Genetic mutation><Germ Lines><Germ-Line Mutation><Goals><Hereditary><Hereditary Breast Cancer 1><Hereditary Mutation><Homologous Chemotactic Cytokines><Human><Immune><Immune Surveillance><Immune mediated therapy><Immune response><Immunes><Immunochemical Immunologic><Immunologic><Immunologic Surveillance><Immunological><Immunologically><Immunologically Directed Therapy><Immunologics><Immunoprevention><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunosurveillance><Immunotherapy><Incidence><Infiltration><Inherited><Intercept><Intercrines><Interdisciplinary Research><Interdisciplinary Study><Intestinal Cancer><Intraductal Carcinoma><Intraductal Carcinoma of the Breast><Knock-out><Knockout><LYT3><Lesion><MGF Stem Cell Factor><MGSA><MIP-2A><MIP2-alpha><MIP2A><MIP2α><Malignant><Malignant - descriptor><Malignant Breast Neoplasm><Malignant Intestinal Neoplasm><Malignant Intestinal Tumor><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Skin Neoplasm><Malignant Tumor><Malignant neoplasm of pancreas><Mammary Gland Parenchyma><Mammary Gland Tissue><Mast Cell Growth Factor><Mediating><Modeling><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Multidisciplinary Collaboration><Multidisciplinary Research><Multimodal Therapy><Multimodal Treatment><Mutation><Myeloid-derived suppressor cells><Non-Infiltrating Ductal Breast Adenocarcinoma><Non-Infiltrating Ductal Carcinoma of the Breast><Non-Infiltrating Intraductal Adenocarcinoma><Non-Infiltrating Intraductal Breast Adenocarcinoma><Non-Invasive Ductal Breast Adenocarcinoma><Non-Invasive Ductal Carcinoma of the Breast><Non-Invasive Intraductal Breast Adenocarcinoma><Noninfiltrating Intraductal Carcinoma><Oncogenic><Oncoprotein p53><Outcome><P53><Pancreas Cancer><Pancreatic Cancer><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phosphoprotein P53><Phosphoprotein pp53><Preventative strategy><Prevention strategy><Preventive strategy><Process><Progenitor Cells><Protein TP53><RNF53><Research><Research Resources><Resources><Risk><Role><SCYB1><SCYB2><SIS cytokines><Skin Cancer><Small Inducible Cytokine Subfamily B, Member 2><Steel Factor><Stem Cell Factor><T cell infiltration><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><T8 Cells><T8 Lymphocytes><TP53><TP53 gene><TRP53><Testing><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Protein p53><Tumor Protein p53 Gene><Tumor Suppressor Proteins><Upregulation><V-set domain containing T cell activation inhibitor 1><VTCN1><VTCN1 gene><Woman><aggressive breast cancer><brca 1 gene><breast epithelium><breast progenitor><breast progenitor cell><breast stem cell><breast tumor cell><breast tumorigenesis><c-kit Ligand><cancer disparity><cancer health disparity><cancer immunology><cancer prevention><cancer progression><cancer sub-types><cancer subtypes><cancer type><cancer-related health disparity><cancer/testis antigen><cell type><chemoattractant cytokine><chemokine><combination therapy><combined modality treatment><combined treatment><determine efficacy><disparity in cancer><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><evaluate vaccines><examine efficacy><genome mutation><germ-line defect><germline variant><high risk><host response><immune check point><immune checkpoint><immune clearance><immune elimination><immune microenvironment><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immunecheckpoint><immuno therapy><immunogenic><immunogenicity><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive microenvironment><immunosuppressive myeloid cells><immunosuppressive response><immunosuppressive tumor microenvironment><improved outcome><innovate><innovation><innovative><intestine cancer><kit Ligand><macrophage inflammatory protein 2><malignancy><malignant breast tumor><malignant intestine neoplasm><malignant intestine tumor><malignant skin tumor><mammary><mammary cancer prevention><mammary epithelium><mammary gland progenitor><mammary gland stem cells><mammary progenitor><mammary stem cells><mammary tumor prevention><molecular profile><molecular signature><mouse model><multi-modal therapy><multi-modal treatment><multipotency><multipotent><multipotent cell><murine model><mutant><mutation carrier><myeloid suppressor cells><myeloid-derived suppressive cells><neoplasm immunology><neoplasm progression><neoplasm/cancer><neoplastic progression><novel><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pancreatic malignancy><pathway><patient oriented outcomes><precancer><precancerous><premalignant><prevent breast cancer><progenitor biology><progenitor cell biology><progenitor-like cell><protein p53><recruit><social role><stem and progenitor biology><stem cell biology><stem cells><stem-like cell><suppressive myeloid cells><thymus derived lymphocyte><tool><transcription factor><tumor><tumor immune microenvironment><tumor immunology><tumor progression><tumor suppressor><tumor-immune system interactions><vaccine evaluation><vaccine screening><vaccine testing><young woman><β-GRO protein>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

SHANNON L MCKINNEY-FREEMAN

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$673,150
FY 2026

Project Title

Investigating hematopoietic stem cell dysfunction during sickle cell disease

Grant Number:

5R01HL168893-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Chronic insults, such as inflammation and replicative stress, impair and exhaust blood-sustaining hematopoietic stem cells (HSCs), leading to dysfunction and selection for leukemia-associated mutations. We propose to study HSC insults in sickle cell disease (SCD), a chronic hemolytic...

Research Terms

<AMD-3100><AMD3100><Age><Age Months><Age of Onset><Allogenic><Antibodies><Antioncogene Protein p53><Apoptosis><Apoptosis Pathway><Assay><Autologous><BUdR><Bioassay><Biological Assay><Biological Markers><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Bone Marrow><Bone Marrow Grafting><Bone Marrow Reticuloendothelial System><Bone Marrow Transplant><Bone Marrow Transplantation><BrdU><Bromodeoxyuridine><Bromouracil Deoxyriboside><Broxuridine><CD34><CD34 gene><Cell Aging><Cell Body><Cell Cycle><Cell Division Cycle><Cell Isolation><Cell Segregation><Cell Senescence><Cell Separation><Cell Separation Technology><Cell Size><Cell surface><Cells><Cellular Aging><Cellular Assay><Cellular Senescence><Cellular Tumor Antigen P53><Childhood><Chronic><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><DNA Damage><DNA Injury><DNA Therapy><DNA mutation><Data><Drugs><Dysfunction><Ferroprotoporphyrin><Functional disorder><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transfer Clinical><Genetic Change><Genetic Intervention><Genetic defect><Genetic mutation><HPCA1><HSC transplantation><Hb SS disease><HbSS disease><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoietic><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Heme><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hemolysis><Hemolytic Anemia><Hemopexin><Hereditary><Heterograft><Heterologous Transplantation><Human><Hydroxycarbamid><Hydroxycarbamide><Immune><Immunes><Impairment><Individual><Inflammation><Inflammatory><Inherited><Marrow Transplantation><Medication><Mice><Mice Mammals><Microscopy><Modern Man><Molecular><Molecular Disease><Murine><Mus><Mutation><Non-Polyadenylated RNA><Oncoprotein p53><Output><P53><Pathologic><Patients><Pharmaceutical Preparations><Phenotype><Phosphoprotein P53><Phosphoprotein pp53><Physiologic><Physiologic pulse><Physiological><Physiopathology><Pilot Projects><Plerixafor><Population><Production><Programmed Cell Death><Protein TP53><Protoheme><Pulse><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Refractory><Replicative Senescence><Resolution><Ribonucleic Acid><Sampling><Sickle Cell Anemia><Staining method><Stains><Stress><Stress Tests><Supporting Cell><TP53><TP53 gene><TRP53><Testing><Time><Transcript Expression Analyses><Transcript Expression Analysis><Transplantation><Tumor Protein p53><Tumor Protein p53 Gene><United States><Xenograft><Xenograft procedure><Xenotransplantation><ages><analyze gene expression><beta-D-Galactosidase><beta-D-Galactoside galactohydrolase><beta-Galactosidase><bio-markers><biologic marker><biomarker><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell transplantation><blood-forming stem cell><cell age><cell assay><cell sorting><cellular age><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><curative intervention><curative therapeutic><curative therapy><curative treatments><drug/agent><erythrolysis><exhaust><experience><ferroheme><fitness><functional restoration><gene expression analysis><gene expression assay><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genome mutation><genomic therapy><hematopoietic cell clones><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem cell clonality><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><hydroxy-urea><hydroxyurea><in vivo><inhibitor><lac Z Protein><leukemia><mid life><mid-life><middle age><middle aged><midlife><mouse model><multiorgan damage><murine model><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pathophysiology><pediatric><peripheral blood><pilot study><premature><prematurity><prevent><preventing><progenitor><progenitor cell function><progenitor cell pool><progenitor cell population><progenitor function><progenitor pool><progenitor population><programs><protein p53><reconstitute><reconstitution><repair><repaired><replicative aging><resolutions><restore function><restore functionality><restore lost function><self-renew><self-renewal><senescence><senescent><senescent cell><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><stem><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor function><stem cell function><stem cell gene therapy><stem cell pool><stem cell population><telomere><transcriptional profiling><transcriptome sequencing><transcriptomic sequencing><transcriptomics><transplant><uptake><vaso-occlusive pain><vasoocclusive pain><xeno-transplant><xeno-transplantation><β-D-Galactosidase><β-D-Galactoside galactohydrolase><β-Galactosidase>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

MARCUS O MUENCH

VITALANT , SCOTTSDALE, AZ

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$662,383
FY 2026

Project Title

Hematopoietic and Immune Development in the Human Chorion

Grant Number:

5R01AI168322-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/11/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract: Hematopoiesis occurs at multiple sites during human prenatal development. In addition to the primary intraembryonic hematopoietic tissues, it is now recognized that the extra-embryonic tissues – the placenta and chorion – contain hematopoietic stem cells. The presence of he...

Research Terms

<1st trimester><Active Sites><Activities of Daily Living><Activities of everyday life><Address><Amnionitides><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Assay><Bioassay><Biological Assay><Biology><Blood Cells><Blood Precursor Cell><Blood monocyte><Body Tissues><CD34><CD34 gene><California><Cell Body><Cell Culture Techniques><Cell Isolation><Cell Line><Cell Segregation><Cell Separation><Cell Separation Technology><CellLine><Cells><Cells Placenta-Tissue><Cerebral Palsy><Chorioamnionitis><Chorion><Chronic><Chronologic Fetal Maturity><Collaborations><Data><Decidua><Decidua Graviditas><Development><Early Placental Phase><Embryo><Embryonic><Embryonic Tissue><Endometrium><Fetal Age><Fetal Membranes><Fetus><First Pregnancy Trimester><First Trimester><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Fostering><Gene Expression><Gestation><Gestational Age><HPCA1><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Human><Human Development><Immune><Immune system><Immunes><Immunity><Immunochemical Immunologic><Immunodeficient Mouse><Immunologic><Immunological><Immunologically><Immunologics><Immunomodulation><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><In Situ><In Vitro><Infection><Infection of amniotic cavity><Infection of amniotic sac and membranes><Infection prevention><Invaded><Laboratories><Low Birth Weight Infant><Lymphatic cell><Lymphocyte><Lymphocytic><Macrophage><Marrow monocyte><Maternal-Fetal Exchange><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Modeling><Modern Man><Mothers><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><Myelopoiesis><Mφ><Neonatal Mortality><Normal Placentoma><Pathologic><Peripheral Blood Cell><Phenotype><Placenta><Placenta Embryonic Tissue><Placentome><Play><Population><Pregnancy><Premature Birth><Prematurely delivering><Preterm Birth><Prevent infection><Production><Proliferating><Regulation><Reporting><Research Institute><Role><San Francisco><Sentinel><Site><Spleen><Spleen Reticuloendothelial System><Strains Cell Lines><Supporting Cell><Surface><T cell regulation><T-Cell Activation><T-Cells><T-Lymphocyte><Testing><Tissues><Transplacental Exposure><Transplantation><Universities><Uterine lining><Villus><Work><activate T cells><amnion><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cell culture><cell cultures><cell sorting><cell type><cultured cell line><cytokine><cytotrophoblast><daily living function><daily living functionality><death among neonates><death among newborns><death in neonates><death in newborn><developmental><embryo tissue><embryo/fetus><experiment><experimental research><experimental study><experiments><fetal><fetus membrane><first responder><flow cytophotometry><functional ability><functional capacity><hematopoietic progenitor><hematopoietic stem progenitor cell><hematopoietic tissue><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><immune modulation><immune regulation><immune suppression><immune suppressive activity><immune suppressive function><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunosuppressive activity><immunosuppressive function><immunosuppressive response><in vitro Assay><inflammatory environment><inflammatory milieu><insight><intra-amniotic infection><intraamniotic infection><low birth weight><low birthweight><lymph cell><maternal immune system><maternal-fetal interface><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><microorganism><monocyte><mortality among neonates><mortality among newborns><mortality in neonates><mortality in newborns><mother immune system><myeloid precursor><myeloid stem and progenitor cell><neonatal death><neonatal demise><newborn death><newborn mortality><premature childbirth><premature delivery><prenatal><preterm delivery><prevent><preventing><progenitor><progenitor cell pool><progenitor cell population><progenitor pool><progenitor population><protein expression><social role><source localization><stem and progenitor cell population><stem cell pool><stem cell population><thymus derived lymphocyte><transplant><transplant model><trophoblast progenitor><trophoblast progenitor cell><trophoblast stem cell><unborn><ward>
View Full Project Details on NIH Reporter
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JACQUELINE C BRESNAHAN

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$656,409
FY 2026

Project Title

Embryonic Stem Cell Therapy after Cervical Contusion SCI in NHPs

Grant Number:

5R01NS130033-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This new application represents a continuation of the California Primate Spinal Cord Research Consortium project on human embryonic stem cell (hESC) derived neural stem cell transplantation; our overarching goal is to understand both basic mechanisms of spinal cord organization and function in non-h...

Research Terms

<4-Aminopyridine><4-Pyridinamine><Agonist><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Axon><Bruise><CRISPR><CRISPR/Cas system><California><Cell Body><Cells><Cervical><Clustered Regularly Interspaced Short Palindromic Repeats><Common Rat Strains><Complementary DNA><Contusions><DREADDs><Data><Disseminated Sclerosis><Doctor of Philosophy><Drugs><ES cell><Electrophysiology><Electrophysiology (science)><Exhibits><Foundations><Future><Goals><Grant><Human><In Vitro><Injections><Knowledge><Lead><Leadership><Lesion><Literature><M mulatta><M. mulatta><MMAC1><MMAC1 protein><Macaca mulatta><Macaca rhesus><Mediating><Medication><Medulla Spinalis><Methods><Mice><Mice Mammals><Modern Man><Molecular><Monkeys><Motor Cortex><Movement><Multiple Sclerosis><Murine><Mus><Mutated in Multiple Advanced Cancers 1><Natural regeneration><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><PHTS gene><PHTS protein><PTEN><PTEN gene><PTEN protein><PTEN1><Pb element><Performance><Ph.D.><PhD><Pharmaceutical Preparations><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Position><Positioning Attribute><Primates><Primates Mammals><Progenitor Cell Transplantation><Pymadine><Rat><Rats Mammals><Rattus><Recovery><Recovery of Function><Regeneration><Research><Rhesus Macaque><Rhesus Monkey><Rodent><Rodentia><Rodents Mammals><Role><Site><Spinal Cord><Spinal Cord Contusions><Spinal Cord Trauma><Spinal Trauma><Spinal cord injured><Spinal cord injury><Stem Cell Transplantation><Stem cell transplant><Technology><Text><Translations><Transplantation><Traumatic Myelopathy><Work><axon regeneration><axonal regeneration><body movement><brain implant><cDNA><designer receptors exclusively activated by designer drugs><drug/agent><electrophysiological><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><functional improvement><functional outcomes><functional recovery><hESC><heavy metal Pb><heavy metal lead><human ES cell><human ESC><human embryonic stem cell><improve function><improved><improved functional outcomes><insular sclerosis><knock-down><knockdown><member><model of animal><motor recovery><mutated in multiple advanced cancers 1 protein><nerve stem cell><neural><neural circuit><neural circuitry><neural implant><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurocircuitry><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><non-human primate><nonhuman primate><pharmacologic><phosphatase and tensin homologue on chromosome ten><progenitor and neural stem cells><progenitor cell based therapy><progenitor cell fate><progenitor cell therapy><progenitor cell treatment><progenitor fate><progenitor therapy><progenitor transplantation><progenitor treatment><regenerate><regeneration based therapy><regeneration therapy><regenerative therapeutics><regenerative therapy><shRNA><short hairpin RNA><small hairpin RNA><social role><stem and progenitor cell fate><stem and progenitor cell therapy><stem and progenitor cell transplantations><stem cell based therapy><stem cell fate><stem cell mediated therapy><stem cell of embryonic origin><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><synaptic circuit><synaptic circuitry><translation><transplant>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Michael S Beattie

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$656,409
FY 2026

Project Title

Embryonic Stem Cell Therapy after Cervical Contusion SCI in NHPs

Grant Number:

5R01NS130033-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This new application represents a continuation of the California Primate Spinal Cord Research Consortium project on human embryonic stem cell (hESC) derived neural stem cell transplantation; our overarching goal is to understand both basic mechanisms of spinal cord organization and function in non-h...

Research Terms

<4-Aminopyridine><4-Pyridinamine><Agonist><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Axon><Bruise><CRISPR><CRISPR/Cas system><California><Cell Body><Cells><Cervical><Clustered Regularly Interspaced Short Palindromic Repeats><Common Rat Strains><Complementary DNA><Contusions><DREADDs><Data><Disseminated Sclerosis><Doctor of Philosophy><Drugs><ES cell><Electrophysiology><Electrophysiology (science)><Exhibits><Foundations><Future><Goals><Grant><Human><In Vitro><Injections><Knowledge><Lead><Leadership><Lesion><Literature><M mulatta><M. mulatta><MMAC1><MMAC1 protein><Macaca mulatta><Macaca rhesus><Mediating><Medication><Medulla Spinalis><Methods><Mice><Mice Mammals><Modern Man><Molecular><Monkeys><Motor Cortex><Movement><Multiple Sclerosis><Murine><Mus><Mutated in Multiple Advanced Cancers 1><Natural regeneration><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><PHTS gene><PHTS protein><PTEN><PTEN gene><PTEN protein><PTEN1><Pb element><Performance><Ph.D.><PhD><Pharmaceutical Preparations><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Position><Positioning Attribute><Primates><Primates Mammals><Progenitor Cell Transplantation><Pymadine><Rat><Rats Mammals><Rattus><Recovery><Recovery of Function><Regeneration><Research><Rhesus Macaque><Rhesus Monkey><Rodent><Rodentia><Rodents Mammals><Role><Site><Spinal Cord><Spinal Cord Contusions><Spinal Cord Trauma><Spinal Trauma><Spinal cord injured><Spinal cord injury><Stem Cell Transplantation><Stem cell transplant><Technology><Text><Translations><Transplantation><Traumatic Myelopathy><Work><axon regeneration><axonal regeneration><body movement><brain implant><cDNA><designer receptors exclusively activated by designer drugs><drug/agent><electrophysiological><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><functional improvement><functional outcomes><functional recovery><hESC><heavy metal Pb><heavy metal lead><human ES cell><human ESC><human embryonic stem cell><improve function><improved><improved functional outcomes><insular sclerosis><knock-down><knockdown><member><model of animal><motor recovery><mutated in multiple advanced cancers 1 protein><nerve stem cell><neural><neural circuit><neural circuitry><neural implant><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurocircuitry><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><non-human primate><nonhuman primate><pharmacologic><phosphatase and tensin homologue on chromosome ten><progenitor and neural stem cells><progenitor cell based therapy><progenitor cell fate><progenitor cell therapy><progenitor cell treatment><progenitor fate><progenitor therapy><progenitor transplantation><progenitor treatment><regenerate><regeneration based therapy><regeneration therapy><regenerative therapeutics><regenerative therapy><shRNA><short hairpin RNA><small hairpin RNA><social role><stem and progenitor cell fate><stem and progenitor cell therapy><stem and progenitor cell transplantations><stem cell based therapy><stem cell fate><stem cell mediated therapy><stem cell of embryonic origin><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><synaptic circuit><synaptic circuitry><translation><transplant>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ephron Solomon Rosenzweig

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$656,409
FY 2026

Project Title

Embryonic Stem Cell Therapy after Cervical Contusion SCI in NHPs

Grant Number:

5R01NS130033-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This new application represents a continuation of the California Primate Spinal Cord Research Consortium project on human embryonic stem cell (hESC) derived neural stem cell transplantation; our overarching goal is to understand both basic mechanisms of spinal cord organization and function in non-h...

Research Terms

<4-Aminopyridine><4-Pyridinamine><Agonist><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Axon><Bruise><CRISPR><CRISPR/Cas system><California><Cell Body><Cells><Cervical><Clustered Regularly Interspaced Short Palindromic Repeats><Common Rat Strains><Complementary DNA><Contusions><DREADDs><Data><Disseminated Sclerosis><Doctor of Philosophy><Drugs><ES cell><Electrophysiology><Electrophysiology (science)><Exhibits><Foundations><Future><Goals><Grant><Human><In Vitro><Injections><Knowledge><Lead><Leadership><Lesion><Literature><M mulatta><M. mulatta><MMAC1><MMAC1 protein><Macaca mulatta><Macaca rhesus><Mediating><Medication><Medulla Spinalis><Methods><Mice><Mice Mammals><Modern Man><Molecular><Monkeys><Motor Cortex><Movement><Multiple Sclerosis><Murine><Mus><Mutated in Multiple Advanced Cancers 1><Natural regeneration><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><PHTS gene><PHTS protein><PTEN><PTEN gene><PTEN protein><PTEN1><Pb element><Performance><Ph.D.><PhD><Pharmaceutical Preparations><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Position><Positioning Attribute><Primates><Primates Mammals><Progenitor Cell Transplantation><Pymadine><Rat><Rats Mammals><Rattus><Recovery><Recovery of Function><Regeneration><Research><Rhesus Macaque><Rhesus Monkey><Rodent><Rodentia><Rodents Mammals><Role><Site><Spinal Cord><Spinal Cord Contusions><Spinal Cord Trauma><Spinal Trauma><Spinal cord injured><Spinal cord injury><Stem Cell Transplantation><Stem cell transplant><Technology><Text><Translations><Transplantation><Traumatic Myelopathy><Work><axon regeneration><axonal regeneration><body movement><brain implant><cDNA><designer receptors exclusively activated by designer drugs><drug/agent><electrophysiological><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><functional improvement><functional outcomes><functional recovery><hESC><heavy metal Pb><heavy metal lead><human ES cell><human ESC><human embryonic stem cell><improve function><improved><improved functional outcomes><insular sclerosis><knock-down><knockdown><member><model of animal><motor recovery><mutated in multiple advanced cancers 1 protein><nerve stem cell><neural><neural circuit><neural circuitry><neural implant><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurocircuitry><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><non-human primate><nonhuman primate><pharmacologic><phosphatase and tensin homologue on chromosome ten><progenitor and neural stem cells><progenitor cell based therapy><progenitor cell fate><progenitor cell therapy><progenitor cell treatment><progenitor fate><progenitor therapy><progenitor transplantation><progenitor treatment><regenerate><regeneration based therapy><regeneration therapy><regenerative therapeutics><regenerative therapy><shRNA><short hairpin RNA><small hairpin RNA><social role><stem and progenitor cell fate><stem and progenitor cell therapy><stem and progenitor cell transplantations><stem cell based therapy><stem cell fate><stem cell mediated therapy><stem cell of embryonic origin><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><synaptic circuit><synaptic circuitry><translation><transplant>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

MARK H. TUSZYNSKI

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$656,409
FY 2026

Project Title

Embryonic Stem Cell Therapy after Cervical Contusion SCI in NHPs

Grant Number:

5R01NS130033-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This new application represents a continuation of the California Primate Spinal Cord Research Consortium project on human embryonic stem cell (hESC) derived neural stem cell transplantation; our overarching goal is to understand both basic mechanisms of spinal cord organization and function in non-h...

Research Terms

<4-Aminopyridine><4-Pyridinamine><Agonist><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Axon><Bruise><CRISPR><CRISPR/Cas system><California><Cell Body><Cells><Cervical><Clustered Regularly Interspaced Short Palindromic Repeats><Common Rat Strains><Complementary DNA><Contusions><DREADDs><Data><Disseminated Sclerosis><Doctor of Philosophy><Drugs><ES cell><Electrophysiology><Electrophysiology (science)><Exhibits><Foundations><Future><Goals><Grant><Human><In Vitro><Injections><Knowledge><Lead><Leadership><Lesion><Literature><M mulatta><M. mulatta><MMAC1><MMAC1 protein><Macaca mulatta><Macaca rhesus><Mediating><Medication><Medulla Spinalis><Methods><Mice><Mice Mammals><Modern Man><Molecular><Monkeys><Motor Cortex><Movement><Multiple Sclerosis><Murine><Mus><Mutated in Multiple Advanced Cancers 1><Natural regeneration><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><PHTS gene><PHTS protein><PTEN><PTEN gene><PTEN protein><PTEN1><Pb element><Performance><Ph.D.><PhD><Pharmaceutical Preparations><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Position><Positioning Attribute><Primates><Primates Mammals><Progenitor Cell Transplantation><Pymadine><Rat><Rats Mammals><Rattus><Recovery><Recovery of Function><Regeneration><Research><Rhesus Macaque><Rhesus Monkey><Rodent><Rodentia><Rodents Mammals><Role><Site><Spinal Cord><Spinal Cord Contusions><Spinal Cord Trauma><Spinal Trauma><Spinal cord injured><Spinal cord injury><Stem Cell Transplantation><Stem cell transplant><Technology><Text><Translations><Transplantation><Traumatic Myelopathy><Work><axon regeneration><axonal regeneration><body movement><brain implant><cDNA><designer receptors exclusively activated by designer drugs><drug/agent><electrophysiological><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><functional improvement><functional outcomes><functional recovery><hESC><heavy metal Pb><heavy metal lead><human ES cell><human ESC><human embryonic stem cell><improve function><improved><improved functional outcomes><insular sclerosis><knock-down><knockdown><member><model of animal><motor recovery><mutated in multiple advanced cancers 1 protein><nerve stem cell><neural><neural circuit><neural circuitry><neural implant><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurocircuitry><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><non-human primate><nonhuman primate><pharmacologic><phosphatase and tensin homologue on chromosome ten><progenitor and neural stem cells><progenitor cell based therapy><progenitor cell fate><progenitor cell therapy><progenitor cell treatment><progenitor fate><progenitor therapy><progenitor transplantation><progenitor treatment><regenerate><regeneration based therapy><regeneration therapy><regenerative therapeutics><regenerative therapy><shRNA><short hairpin RNA><small hairpin RNA><social role><stem and progenitor cell fate><stem and progenitor cell therapy><stem and progenitor cell transplantations><stem cell based therapy><stem cell fate><stem cell mediated therapy><stem cell of embryonic origin><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><synaptic circuit><synaptic circuitry><translation><transplant>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

IRWIN D BERNSTEIN

FRED HUTCHINSON CANCER CENTER, SEATTLE, WA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$646,305
FY 2026

Project Title

DLK1 regulates HSC quiescence through phase separation mediated inhibition of receptor signaling

Grant Number:

5R01HL173520-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2025

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary: While much is known about factors that stimulate the proliferation and differentiation of stem cells, less is known about the factors that prevent their differentiation and preserve their function. One factor implicated in the maintenance of an undifferentiated stem cell state is th...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Affinity><Binding><Blood Cells><Blood Precursor Cell><Body Tissues><CD34><CD34 gene><CD34+ precursor><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation Inhibition><Cell Differentiation process><Cell Signaling><Cell division><Cell membrane><Cells><Co-culture><Cocultivation><Coculture><Coculture Techniques><Cord Blood><Cytoplasmic Membrane><DNA Synthesis Factor><DNA Therapy><Development><Disease><Disorder><Effectiveness><Embryo Development><Embryogenesis><Embryonic Development><Endothelial Cell Growth Factor><Endothelial Cells><Engraftment><Exposure to><External Domain><Extracellular Domain><FGF><Fibroblast Growth Factor><Fibroblast Growth Factor Gene Family><Fibroblast Growth Regulatory Factor><Foundations><Gene Expression><Gene Transcription><Gene Transfer Clinical><GeneHomolog><Generations><Genetic Intervention><Genetic Transcription><Goals><HPCA1><HSC aging><HSC quiescence><HSC transplantation><Hematopoietic><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Homolog><Homologous Gene><Homologue><Humulin R><In Vitro><Insulin><Intracellular Communication and Signaling><Lead><Ligands><Maintenance><Mediating><Mice><Mice Mammals><Modeling><Molecular Interaction><Monitor><Murine><Mus><Myelogenous><Myeloid><Nature><Notch Signaling Pathway><Novolin R><Organ Size><Organism><Pathway interactions><Pb element><Peripheral Blood Cell><Phase><Phenotype><Physical condensation><Plasma Membrane><Population><Prevention><Process><Progenitor Cells><Proliferating><Proteins><Proteolysis and Signaling Pathway of Notch><RNA Expression><Receptor Activation><Receptor Inhibition><Receptor Protein><Receptor Signaling><Regular Insulin><Reporting><Reproducibility><Resting progenitor><Signal Induction><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Supporting Cell><Testing><Therapeutic><Tissues><Transcription><Transplantation><Umbilical Cord Blood><Undifferentiated><adulthood><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood stem cell quiescence><blood stem cell transplantation><blood-forming stem cell><cellular differentiation><condensation><developmental><dormant stem cell><engineered progenitor cells><engineered stem cells><experiment><experimental research><experimental study><experiments><extracellular><fetal cord blood><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><heavy metal Pb><heavy metal lead><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem cell aging><hematopoietic stem cell quiescence><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><hypoimmunity><immune deficiency><immunodeficiency><in vivo><inactive stem cell><knock-down><knockdown><latent progenitor><latent stem cell><living system><mutant><new approaches><notch><notch protein><notch receptors><novel approaches><novel strategies><novel strategy><overexpress><overexpression><pathway><plasmalemma><preservation><prevent><preventing><progenitor Cell growth><progenitor cell differentiation><progenitor cell expansion><progenitor cell function><progenitor cell proliferation><progenitor differentiation><progenitor expansion><progenitor function><progenitor growth><progenitor proliferation><quiescent progenitor><quiescent stem cells><receptor><resting stem cell><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><stem and progenitor cell expansion><stem and progenitor cell function><stem and progenitor cell proliferation><stem and progenitor differentiation><stem and progenitor function><stem cell differentiation><stem cell expansion><stem cell function><stem cell growth><stem cell proliferation><stem cell quiescence><stem cells><success><trafficking><transplant>
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Timothy Michael Chlon

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$645,245
FY 2026

Project Title

The Effect of DDX41 Mutations on Hematopoiesis During Aging

Grant Number:

1R01AG093208-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Myelodysplastic Syndromes (MDS) are a group of bone marrow failure disorders caused by clonal expansion of hematopoietic stem cells (HSC) that fail to produce mature blood cells of sufficient quality and quantity. The disease-causing HSC bear acquired mutations that confer a selective advantage comp...

Research Terms

<Accounting><Affect><Age><Aging><Alleles><Allelomorphs><Amino Acids><Antimorphic mutation><Antioncogene Protein p53><Assay><Automobile Driving><Bioassay><Biogenesis><Biological Assay><Blood><Blood Cells><Blood Precursor Cell><Blood Reticuloendothelial System><Bone Marrow><Bone Marrow Blood-Deriving Cell><Bone Marrow Blood-Forming Cell><Bone Marrow Cells><Bone Marrow Hypoplasia><Bone Marrow Reticuloendothelial System><Bone marrow failure><Cancer Genes><Cancer-Promoting Gene><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Line><Cell Multiplication><Cell Proliferation><Cell Signaling><Cell Survival><Cell Viability><CellLine><Cells><Cellular Proliferation><Cellular Tumor Antigen P53><Chimerism><Clinical><Clonal Expansion><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><DNA mutation><DNA seq><DNA sequencing><DNAseq><Data><Defect><Diagnosis><Disease><Disease Progression><Disorder><Dominant Negative><Dominant-Negative Mutant><Dominant-Negative Mutation><Dysmyelopoietic Syndromes><Elderly><Frequencies><Gene Alteration><Gene Mutation><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Germ Lines><Goals><HSC aging><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Hereditary><Heterozygote><Human><Hypercellular Bone Marrow><Hypocellular Bone Marrow><Immune signaling><Individual><Inherited><Intracellular Communication and Signaling><Leukemic Cell><Maintenance><Mice><Mice Mammals><Missense Mutation><Mitochondria><Modeling><Modern Man><Murine><Mus><Mutate><Mutation><Myelodysplastic Disease><Myelodysplastic Syndromes><Myelogenous><Myeloid><Myeloid Cells><Non-Polyadenylated RNA><Oncogenes><Oncoprotein p53><Origin of Life><P53><Pathogenesis><Pathogenicity><Pathology><Pathway interactions><Patient-specific stem cells><Patients><Penetrance><Peripheral Blood Cell><Persons><Phenotype><Phosphoprotein P53><Phosphoprotein pp53><Predisposition><Preventative strategy><Prevention strategy><Preventive strategy><Process><Production><Progenitor Cells><Proliferating><Protein Biosynthesis><Protein TP53><Proteins><Publishing><RNA><RNA Gene Products><RNA Helicase><RNA Seq><RNA Splicing><RNA sequencing><RNAseq><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Ribonucleic Acid><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Ribosomes><Risk><Sampling><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Small Nucleolar RNA><Smoldering Leukemia><Splicing><Strains Cell Lines><Stress><Susceptibility><Syndrome><TP53><TP53 gene><TRP53><Testing><Therapeutic><Transforming Genes><Translations><Transplantation><Tumor Protein p53><Tumor Protein p53 Gene><Variant><Variation><advanced age><age associated><age associated effects><age correlated><age dependent><age effect><age linked><age related><age related effects><age specific><aged><aged mice><aged mouse><ages><aging associated><aging effect><aging related><aminoacid><biological signal transduction><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><cultured cell line><cytopenia><death risk><disease model><disease prevention><disorder model><disorder prevention><drivers of aging><driving><elderly mice><fitness><gene defect><genome mutation><geriatric><gerodriver><hematopoietic cell clones><hematopoietic progenitor><hematopoietic stem cell aging><hematopoietic stem cell clonality><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><heterozygosity><high risk><iPS><iPSC><iPSCs><impact of age><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><influence of age><loss of function><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><mitochondrial><mortality risk><mouse model><multipotency><multipotent><murine model><mutant><mutant allele><myelodysplasia><novel><old mice><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pathway><patient progenitor cell><patient stem cell><pharmacologic><pre-clinical><preclinical><prevent><preventing><progenitor><progenitor cell expansion><progenitor cell function><progenitor cell homeostasis><progenitor cell pool><progenitor cell population><progenitor cell proliferation><progenitor expansion><progenitor function><progenitor pool><progenitor population><progenitor proliferation><protein function><protein p53><protein synthesis><proteotoxic><proteotoxicity><response><senior citizen><snoRNA><stem and progenitor cell expansion><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor cell proliferation><stem and progenitor function><stem cell expansion><stem cell function><stem cell homeostasis><stem cell pool><stem cell population><stem cell proliferation><stem cells><stressor><tissue progenitor><tissue specific progenitor cells><tissue specific stem cells><tissue stem cells><transcriptome sequencing><transcriptomic sequencing><translation><transplant>
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Lucy Erin O'Brien

STANFORD UNIVERSITY, STANFORD, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$630,654
FY 2026

Project Title

Lineage tradeoffs during injury-accelerated intestinal cell differentiation

Grant Number:

1R01DK143514-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Barrier epithelia face continual damage from environmental insults, and successful injury repair is crucial for organismal health. A prime case study is the one-cell-thick intestinal epithelium, which forms a leakproof bar- rier between the gut lumen and the body cavity. To replace d...

Research Terms

<21+ years old><Acceleration><Adult><Adult Human><Autoregulation><Biologic Models><Biological Models><Body Tissues><Body cavities><Bolus><Bolus Infusion><C-jun Amino-Terminal Kinase><C-jun Kinase-1><C-jun N-Terminal Kinase 1><CSAID-Binding Protein 1><CSAID-Binding Protein 2><CSBP2><Case Study><Case-Base Studies><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Isolation><Cell Lineage><Cell Locomotion><Cell Migration><Cell Movement><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Shape><Cell Signaling><Cell to Cell Communication and Signaling><Cell-Cell Signaling><Cells><Cellular Migration><Cellular Motility><Cellular injury><Chronic><Cytokine-Suppressive Antiinflammatory Drug-Binding Protein 1><Cytokine-Suppressive Antiinflammatory Drug-Binding protein 2><Daughter><Digestive Physiology><Drosophila><Drosophila genus><Ensure><Enterocytes><Epithelium><Equilibrium><Evolution><Exhibits><Extracellular Signal-Regulated Kinase Gene><Face><Feedback><Flies><Food><Genetic><Health><Hereditary><Homeostasis><Hour><Human><Image><Individual><Inherited><Injury><Intestinal><Intestinal Diseases><Intestinal Disorder><Intestines><Intracellular Communication and Signaling><Investigation><JN Kinase><JNK><JNK Mitogen-Activated Protein Kinases><JNK1><JNK1 Kinase><JNK1 protein><JNK1A2><JNK21B1/2><Lateral><Ligands><Lineage Tracing><Liquid substance><MAP Kinase 8><MAP Kinase 8 Gene><MAP Kinase Gene><MAPK><MAPK14><MAPK14 Mitogen-Activated Protein Kinase><MAPK14 gene><MAPK8><MAPK8 Mitogen-Activated Protein Kinase><MAPK8 gene><Methodology><Mitogen-Activated Protein Kinase 14><Mitogen-Activated Protein Kinase 8><Mitogen-Activated Protein Kinase Gene><Model System><Modern Man><Modification><Morphology><Mxi2><Natural regeneration><Nature><Normal Cell><Organ><Outcome><PRKM8><Pathway interactions><Phase><Physiologic><Physiological><Physiological Homeostasis><Play><Population><Population Analysis><Process><Production><Progenitor Cells><Progenitor cell mobilization><Quality Control><RNA Seq><RNA sequencing><RNAseq><Recovery><Regeneration><Regenerative Medicine><Regenerative response><Research><Resolution><Risk><Role><SAP Kinase-1><SAPK/JNK><SAPK1 Mitogen-Activated Protein Kinase><SAPK1/JNK><SAPK2A><Series><Signal Transduction><Signal Transduction Systems><Signaling><Specific qualifier value><Specified><Speed><Spottings><Stem Cell Mobilization><Stem Cell trafficking><Stress><Stress-Activated Protein Kinase 2A><Stress-Activated Protein Kinase JNK1><Stress-Activated Protein Kinase gamma><System><Testing><Thick><Thickness><Time><Tissues><Toxin><Twin Multiple Birth><Twins><Visualization><Work><adulthood><balance><balance function><base><bases><biological signal transduction><body cavity><bowel><c-jun N-Terminal Kinase><case report><cell behavior><cell damage><cell fate specification><cell injury><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell motility><cell sorting><cellular behavior><cellular damage><cellular differentiation><cellular lineage mapping><cellular lineage tracking><cohort><combat><coping><cost><damage to cells><daughter cell><exhaust><experiment><experimental research><experimental study><experiments><faces><facial><fitness><fluid><fly><frontier><fruit fly><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><global gene expression><global transcription profile><imaging><in vivo><inhibitor><injuries><injury and repair><injury recovery><injury response><injury to cells><injury to the intestines><intercellular communication><intestinal barrier><intestinal epithelium><intestinal injury><intestinal mucosal barrier><intestine disease><intestine disorder><intra-vital imaging><intravital imaging><jun-NH2-Terminal Kinase><lens><lenses><life span><lifespan><liquid><movie><notch><notch protein><notch receptors><organ regeneration><p38><p38 MAP Kinase><p38 MAPK Gene><p38 Mitogen Activated Protein Kinase><p38 Protein Kinase><p38 SAPK><p38-Alpha><p38Alpha><pathway><pressure><progenitor><progenitor cell division><progenitor cell pool><progenitor cell population><progenitor cell renewal><progenitor division><progenitor mobilization><progenitor pool><progenitor population><progenitor renewal><purge><purges><purging><recovery after injury><recovery following injury><recovery post injury><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration model><regeneration response><regenerative><regenerative model><repair><repaired><resolutions><response to injury><restoration><side effect><social role><stem><stem and progenitor cell division><stem and progenitor cell population><stem and progenitor cell renewal><stem cell depletion><stem cell division><stem cell exhaustion><stem cell fatigue><stem cell pool><stem cell population><stem cell renewal><stem cells><stress-activated protein kinase 1><tissue fixing><tissue regeneration><tissue regrowth><tissue renewal><tissue repair><tissue specific regeneration><tool><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics>
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Victor J. Thannickal

TULANE UNIVERSITY OF LOUISIANA, NEW ORLEANS, LA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$626,373
FY 2026

Project Title

Metabolic Reprogramming of the Alveolar Stem Cell Niche in Pulmonary Fibrosis

Grant Number:

5R01HL173154-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Cell metabolism regulates epigenetic reprograming to determine cellular identity and fate. Intermediary metabolites serve as essential cofactors for epigenetic modifying enzymes. Epithelial- mesenchymal crosstalk is critical for the maintenance of adult tissues/organs and in regener...

Research Terms

<1H-Purin-6-amine><21+ years old><3-D><3-Dimensional><3-Pyridinecarboxamide><3D><ATAC sequencing><ATAC-seq><ATACseq><Acceleration><Acetyl CoA><Acetyl Coenzyme A><Acetylation><Address><Ademetionine><Adenine><AdoMet><Adult><Adult Human><Alveolar><Alveoli progenitor><Alveoli stem cell><Animal Model><Animal Models and Related Studies><Apoptosis><Apoptosis Pathway><Applications Grants><Assay for Transposase-Accessible Chromatin using sequencing><Bioenergetics><Body Tissues><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Chromatin><Data><Development><Dihydronicotinamide Adenine Dinucleotide><Diphosphopyridine Nucleotide><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelium><Failure><Fibroblasts><Fibrosing Alveolitis><Fibrosis><Grant Proposals><Human><Impairment><Intermediary Metabolism><Link><Lung><Lung Respiratory System><Lung Tissue Fibrosis><Lung damage><Maintenance><Mammalia><Mammals><Mesenchymal><Mesenchymas><Mesenchyme><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Methylation><Modeling><Modern Man><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Myofibroblast><Nadide><Natural regeneration><Niacinamide><Nicotinamide><Nicotinamide N-Methyltransferase><Nicotinamide adenine dinucleotide><Nicotinamide-Adenine Dinucleotide><Nicotinamidum><Nicotinic acid amide><Nicotylamide><Organ><Organogenesis><Organoids><Pathologic><Pattern><Pellagra-Preventing Factor><Phenotype><Phosphorylation><Physiologic><Physiological><Progenitor Cells><Programmed Cell Death><Protein Methylation><Protein Phosphorylation><Pulmonary Body System><Pulmonary Fibrosis><Pulmonary Organ System><Reaction><Regeneration><Regenerative capacity><Regenerative response><Regulation><Rejuvenation><Resistance><Resolution><Respiratory System><Respiratory Tracts><Respiratory tract structure><Role><S-Adenosylhomocysteine><S-Adenosylmethionine><S-acetate Coenzyme A><S-adenosyl methionine><S-adenosyl-methionine><SAMe><Slice><Stromal Cells><Subcellular Process><Testing><Therapeutic><Tissues><Transforming Growth Factors><Tumor Growth Factors><Vitamin B 3><Vitamin B3><Vitamin B4><Vitamin PP><adulthood><alveolar progenitor><alveolar stem cell><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><cell behavior><cell metabolism><cellular behavior><cellular metabaolism><cofactor><conformation><conformational><conformational state><conformationally><conformations><developmental><diffuse interstitial pulmonary fibrosis><epigenetic profiling><epigenetically><epithelium regeneration><fibrosis in the lung><histone methylation><histone modification><idiopathic pulmonary fibrosis><in vivo><injury and repair><injury to tissue><lung fibrosis><lung injury><metabolism measurement><metabolomics><metabonomics><model of animal><nicotinamide methylase><nicotinamide methyltransferase><nicotinamide-S-adenosylmethionine methyltransferase><pharmacologic><profibrotic cytokine><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor niche><progenitor pool><progenitor population><programs><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><pyridine><regenerate><regenerate epithelium><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration ability><regeneration capacity><regeneration potential><regeneration response><regenerative><regenerative potential><resistant><resolutions><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell niche><stem and progenitor cell population><stem cell niche><stem cell pool><stem cell population><stem cells><three dimensional><tissue injury><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transforming growth factors Animal growth regulators><triphosphate><tripolyphosphate>
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Darcie Leann Moore

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$615,156
FY 2026

Project Title

Label-free, live-cell classification of neural stem cell activation state

Grant Number:

5R01NS138454-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Neural stem cells (NSCs) in the brain proliferate and generate newborn neurons throughout life. Dysfunctions in neurogenesis have been associated with neurological diseases such as epilepsy, depression, and Alzheimer’s Disease. A significant rate-limiting step in adult neurogenesis ...

Research Terms

<AD dementia><Acute><Address><Aging><Agreement><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Ammon Horn><Assay><Astroprotein><Behavior><Benchmarking><Best Practice Analysis><Binding><Bioassay><Biological Assay><Brain><Brain Nervous System><Breeding><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Division Cycle><Cell Fractionation><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Signaling><Cells><Chemicals><Classification><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Cornu Ammonis><DNA Recombination><Data><Deposit><Deposition><Detection><Disease><Disorder><Disturbance in cognition><Dysfunction><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><FLIM imaging><Fluorescence><Functional disorder><Future><GFA-Protein><GFAP><GLAST><GLAST Protein><Gene Expression><Genetic Recombination><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Glutamate-Aspartate Transporter><Heterogeneity><Hippocampus><Image><Imaging technology><Impaired cognition><In Vitro><Injections><Intermediary Metabolism><Intracellular Communication and Signaling><Intrinsic factor><Knowledge><Label><Life><Link><LoxP-flanked allele><Lysosomes><Measures><Mental Depression><Metabolic Pathway><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Molecular><Molecular Interaction><Murine><Mus><Nervous System Diseases><Nervous System Disorder><Neural Stem Cell><Neurologic Disorders><Neurological Disorders><Optics><Organelles><Pathway interactions><Photons><Physiopathology><Population><Primary Senile Degenerative Dementia><Process><Production><Proliferating><Property><Proteins><QOL><Quality of life><Recombination><Regulation><Resolution><Resting progenitor><Seizure Disorder><Signal Transduction><Signal Transduction Systems><Signaling><Societies><Sorting><System><Systematics><Tamoxifen><Techniques><Time><Transcript><Transgenic Mice><Viral><Visualization><adult neurogenesis><adult youth><benchmark><biological signal transduction><cell behavior><cell sorting><cell type><cellular behavior><cognitive dysfunction><cognitive enhancement><cognitive function><cognitive loss><depression><dimension reduction><dimensionality reduction><dormant stem cell><epilepsia><epileptogenic><fat metabolism><floxed><floxed allele><fluorescence life-time imaging><fluorescence life-time imaging microscopy><fluorescence lifetime imaging><fluorescence lifetime imaging microscopy><fluorophore><global gene expression><global transcription profile><hippocampal><image-based method><imaging><imaging method><imaging modality><improved><inactive stem cell><indexing><insight><latent progenitor><latent stem cell><lipid metabolism><lipidomics><live cell image><live cell imaging><live cellular image><live cellular imaging><metabolism measurement><metabolomics><metabonomics><nerve stem cell><nestin><nestin protein><neural control><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural regulation><neural stem and progenitor cells><neurogenesis><neurogenic progenitors><neurogenic stem cell><neurological disease><neuromodulation><neuromodulatory><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><neuroregulation><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><newborn neuron><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><optical><pathophysiology><pathway><primary degenerative dementia><progenitor and neural stem cells><progenitor cell proliferation><progenitor proliferation><prospective><quiescent progenitor><quiescent stem cells><reduce data dimension><reduce dimensionality><resolutions><resting stem cell><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><stem and progenitor cell proliferation><stem cell proliferation><stem cell quiescence><subcellular fractionation><therapeutic agent development><therapeutic development><tool><transcriptome><young adult><young adult age><young adulthood>
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Michael A Pulsipher

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$601,117
FY 2026

Project Title

Donor health-related quality-of-life and physician decision-making in the context of haploidentical hematopoietic stem cell transplantation (HaploQOL)

Grant Number:

5R01HL171117-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2024

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Hematopoietic stem cell transplantation (HSCT) is a preferred treatment for life-threatening diseases and cancers of the blood. HSCT involves exposing the patient to toxic doses of chemotherapy or radiation to destroy diseased cells followed by an infusion of healthy donor cells to rescue the compro...

Research Terms

<0-11 years old><13 year old><13 years of age><21+ years old><Adolescent><Adolescent Youth><Adult><Adult Human><Age><Allogenic><Blood Diseases><Blood Precursor Cell><Caring><Cell Body><Cells><Characteristics><Chemotherapy and Radiation><Chemotherapy and/or radiation><Child><Child Youth><Children (0-21)><Clinical><Consensus><Decision Making><Development><Disease><Disorder><Donor Screening><Donor Selection><Dose><Ethnic Origin><Ethnicity><Family><Focus Groups><Foundations><Frequencies><Geography><Goals><Guidelines><GvHD><HSC transplantation><Health><Health Status><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoietic Cell Tumor><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Hematopoietic stem cells><Homologous Wasting Disease><Immune system><Infusion><Infusion procedures><Interview><Investigation><Level of Health><Life><Living Donors><Malignant Hematopoietic Neoplasm><Matched Group><Medical><Methods><Nature><On-Line Systems><Online Systems><Outcome><Parents><Patients><Pattern><Physician's Practice Patterns><Physicians><Practice Management><Prevention><Probability><Process><QOL><Quality of life><Race><Races><Recommendation><Research><Retrospective cohort><Runt Disease><Sampling><Scientific Advances and Accomplishments><Series><Siblings><Source><Structure><Survey Instrument><Surveys><Telephone Interviews><Transplantation><Variant><Variation><adulthood><age 13><age 13 years><ages><blood cancer><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell transplantation><blood-forming stem cell><cancer of blood><cancer of the blood><chemo/radiation therapy><chemotherapy and radiotherapy><clinical applicability><clinical application><comparator group><comparison group><developmental><ethnic minority><experience><graft versus host disease><graft vs host disease><graft vs. host disease><health level><health related quality of life><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><improved><infusions><innovate><innovation><innovative><juvenile><juvenile human><kids><novel><online computer><parent><psychosocial><racial><racial background><racial origin><radiation or chemotherapy><scientific accomplishments><scientific advances><thirteen year old><thirteen years of age><transplant><transplant centers><web based><youngster>
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GALEN E. SWITZER

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$601,117
FY 2026

Project Title

Donor health-related quality-of-life and physician decision-making in the context of haploidentical hematopoietic stem cell transplantation (HaploQOL)

Grant Number:

5R01HL171117-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2024

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Hematopoietic stem cell transplantation (HSCT) is a preferred treatment for life-threatening diseases and cancers of the blood. HSCT involves exposing the patient to toxic doses of chemotherapy or radiation to destroy diseased cells followed by an infusion of healthy donor cells to rescue the compro...

Research Terms

<0-11 years old><13 year old><13 years of age><21+ years old><Adolescent><Adolescent Youth><Adult><Adult Human><Age><Allogenic><Blood Diseases><Blood Precursor Cell><Caring><Cell Body><Cells><Characteristics><Chemotherapy and Radiation><Chemotherapy and/or radiation><Child><Child Youth><Children (0-21)><Clinical><Consensus><Decision Making><Development><Disease><Disorder><Donor Screening><Donor Selection><Dose><Ethnic Origin><Ethnicity><Family><Focus Groups><Foundations><Frequencies><Geography><Goals><Guidelines><GvHD><HSC transplantation><Health><Health Status><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoietic Cell Tumor><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Hematopoietic stem cells><Homologous Wasting Disease><Immune system><Infusion><Infusion procedures><Interview><Investigation><Level of Health><Life><Living Donors><Malignant Hematopoietic Neoplasm><Matched Group><Medical><Methods><Nature><On-Line Systems><Online Systems><Outcome><Parents><Patients><Pattern><Physician's Practice Patterns><Physicians><Practice Management><Prevention><Probability><Process><QOL><Quality of life><Race><Races><Recommendation><Research><Retrospective cohort><Runt Disease><Sampling><Scientific Advances and Accomplishments><Series><Siblings><Source><Structure><Survey Instrument><Surveys><Telephone Interviews><Transplantation><Variant><Variation><adulthood><age 13><age 13 years><ages><blood cancer><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell transplantation><blood-forming stem cell><cancer of blood><cancer of the blood><chemo/radiation therapy><chemotherapy and radiotherapy><clinical applicability><clinical application><comparator group><comparison group><developmental><ethnic minority><experience><graft versus host disease><graft vs host disease><graft vs. host disease><health level><health related quality of life><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><improved><infusions><innovate><innovation><innovative><juvenile><juvenile human><kids><novel><online computer><parent><psychosocial><racial><racial background><racial origin><radiation or chemotherapy><scientific accomplishments><scientific advances><thirteen year old><thirteen years of age><transplant><transplant centers><web based><youngster>
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Matthew Blake Greenblatt

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$572,832
FY 2026

Project Title

A skeletal stem cell orchestrating limb regeneration

Grant Number:

5R01HD115274-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/2/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Approximately .5% of children are born missing a limb, and 2.1 million in the US alone are living with limb loss. Current management for these patients largely relies on the use of prostheses, however most prosthetic use is marked by significant patient dissatisfaction due to functio...

Research Terms

<0-11 years old><21+ years old><Accounting><Adult><Adult Human><Amniotic Band Syndrome><Amputation><Autologous><Blood Vessels><Body Tissues><Bone Regeneration><Bone callus><Bony Callus><Callus><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cell Transplantation><Cell surface><Cells><Cellularity><Child><Child Youth><Children (0-21)><Chondrocytes><Data><Development><Digit><Digit structure><Distal><Elements><Extremities><Fracture Healing><Gene Transcription><Generalized Growth><Genetic Transcription><Goals><Growth><Harvest><Human><Implant><Injury><Intracellular Communication and Signaling><Joints><Limb Bud><Limb structure><Limbs><Literature><Load Bearing><Malignant Soft Tissue Neoplasm><Mammalia><Mammals><Mediating><Mediator><Mesenchymas><Mesenchyme><Methods><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Natural regeneration><Nature><Non-Trunk><Organism><Orthopedic><Orthopedic Surgical Profession><Orthopedics><Osteoblasts><Patients><Pattern><Periosteum><Periosteums><Physiologic><Physiological><Population><Progenitor Cells><Prosthesis><Prosthetic device><Prosthetics><QOL><Quality of life><RNA Expression><Regeneration><Regenerative capacity><Regenerative response><Role><Sarcoma><Signal Transduction><Signal Transduction Systems><Signaling><Site><Skeleton><Source><Streeter Syndrome><Tissue Growth><Tissues><Transcription><Transplantation><Traumatic injury><Vascular Diseases><Vascular Disorder><Weight Bearing><Weight-Bearing state><adulthood><amputated limb><biological signal transduction><blastema><blood vessel disorder><bone><bone fracture healing><bone fracture repair><cell based intervention><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><cellular transplant><combat><developmental><diabetic><digit regeneration><fetal joint development><fracture repair><functional restoration><healing><implantation><in vivo><in vivo regeneration><injuries><injury and repair><joint formation><kids><limb amputation><limb loss><limb regeneration><living system><lost limb><malignant soft tissue tumor><mouse model><murine model><new approaches><novel approaches><novel strategies><novel strategy><ontogeny><peri-osteal progenitor><peri-osteal stem cells><periosteum stem cell><progenitor in the periosteum><programs><reconstruction><regenerate><regenerate bone><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration ability><regeneration capacity><regeneration response><regenerative><regenerative cell><regenerative tissue><repair><repaired><response><restoration><restore function><restore functionality><restore lost function><skeletal><skeletal progenitor><skeletal progenitor cell><skeletal stem cell><skeletons><social role><stem cell in the periosteum><stem cells><synovial joint development><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptional reprogramming><transplant><vascular><vascular dysfunction><vasculopathy><youngster>
View Full Project Details on NIH Reporter
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Xu Yang

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$572,832
FY 2026

Project Title

A skeletal stem cell orchestrating limb regeneration

Grant Number:

5R01HD115274-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/2/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Approximately .5% of children are born missing a limb, and 2.1 million in the US alone are living with limb loss. Current management for these patients largely relies on the use of prostheses, however most prosthetic use is marked by significant patient dissatisfaction due to functio...

Research Terms

<0-11 years old><21+ years old><Accounting><Adult><Adult Human><Amniotic Band Syndrome><Amputation><Autologous><Blood Vessels><Body Tissues><Bone Regeneration><Bone callus><Bony Callus><Callus><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cell Transplantation><Cell surface><Cells><Cellularity><Child><Child Youth><Children (0-21)><Chondrocytes><Data><Development><Digit><Digit structure><Distal><Elements><Extremities><Fracture Healing><Gene Transcription><Generalized Growth><Genetic Transcription><Goals><Growth><Harvest><Human><Implant><Injury><Intracellular Communication and Signaling><Joints><Limb Bud><Limb structure><Limbs><Literature><Load Bearing><Malignant Soft Tissue Neoplasm><Mammalia><Mammals><Mediating><Mediator><Mesenchymas><Mesenchyme><Methods><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Natural regeneration><Nature><Non-Trunk><Organism><Orthopedic><Orthopedic Surgical Profession><Orthopedics><Osteoblasts><Patients><Pattern><Periosteum><Periosteums><Physiologic><Physiological><Population><Progenitor Cells><Prosthesis><Prosthetic device><Prosthetics><QOL><Quality of life><RNA Expression><Regeneration><Regenerative capacity><Regenerative response><Role><Sarcoma><Signal Transduction><Signal Transduction Systems><Signaling><Site><Skeleton><Source><Streeter Syndrome><Tissue Growth><Tissues><Transcription><Transplantation><Traumatic injury><Vascular Diseases><Vascular Disorder><Weight Bearing><Weight-Bearing state><adulthood><amputated limb><biological signal transduction><blastema><blood vessel disorder><bone><bone fracture healing><bone fracture repair><cell based intervention><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><cellular transplant><combat><developmental><diabetic><digit regeneration><fetal joint development><fracture repair><functional restoration><healing><implantation><in vivo><in vivo regeneration><injuries><injury and repair><joint formation><kids><limb amputation><limb loss><limb regeneration><living system><lost limb><malignant soft tissue tumor><mouse model><murine model><new approaches><novel approaches><novel strategies><novel strategy><ontogeny><peri-osteal progenitor><peri-osteal stem cells><periosteum stem cell><progenitor in the periosteum><programs><reconstruction><regenerate><regenerate bone><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration ability><regeneration capacity><regeneration response><regenerative><regenerative cell><regenerative tissue><repair><repaired><response><restoration><restore function><restore functionality><restore lost function><skeletal><skeletal progenitor><skeletal progenitor cell><skeletal stem cell><skeletons><social role><stem cell in the periosteum><stem cells><synovial joint development><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptional reprogramming><transplant><vascular><vascular dysfunction><vasculopathy><youngster>
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Cambrian Yangshao Liu

UNIVERSITY OF CHICAGO, CHICAGO, IL

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$564,004
FY 2026

Project Title

Colonic epithelial wound healing by anal transitional cells

Grant Number:

5R01DK135954-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Mucosal healing is the primary goal of all therapies for inflammatory bowel disease (IBD). No currently approved therapy directly promotes wound healing of the bowel epithelium, which forms a single-cell barrier between the host and lumen and regulates the immune response. The cellul...

Research Terms

<Ablation><Acute><Anal><Anatomic Sites><Anatomic structures><Anatomy><Anus><Assay><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biological Assay><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cells><Chronic><Colitis><Collection><Colon><Colon Injury><Coloring Agents><Development><Disease Outcome><Distal><Dyes><Epithelial Cells><Epithelium><GI Stem cell><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genetic Transcription><Goals><Growth><Human><Hybrids><Immune response><Immune system><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal><Intestines><Intracellular Communication and Signaling><Investigation><Knowledge><Location><Measures><Mediating><Medical><Mesenchymal><Mesenchymas><Mesenchyme><Metaplasia><Metaplastic Change><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Mucosa><Mucosal Tissue><Mucous Membrane><Multimodal Imaging><Murine><Mus><Natural regeneration><Oncogenesis><Oncogenic><Organoids><Outcome><Pathway interactions><Patients><Penetration><Phenotype><Population><Process><Progenitor Cells><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Expression><Reagent><Regeneration><Regenerative Medicine><Regenerative research><Regenerative response><Relative Risks><Research><Research Grants><Research Project Grants><Research Projects><Research Specimen><Resistance><Risk><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Source><Specimen><Structure><Testing><Therapeutic><Therapeutic Effect><Therapeutic Uses><Tissue Growth><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transitional Cell><Transplantation><Ulcer><Ulceration><Work><Wound Repair><biological signal transduction><bowel><cancer initiation><cancer risk><cell based intervention><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><clinical translation><clinically translatable><colonic crypt><confocal imaging><crypt cell><developmental><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><epithelial wound><epithelium regeneration><gastrointestinal stem cell><gut progenitor><gut stem cell><healing><host response><imaging study><immune system response><immunoresponse><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><intestinal autoinflammation><intestinal crypt><intestinal progenitor><intestinal stem cells><migration><mucosal layer of the rectum><multi-modal imaging><multi-modality imaging><multimodality imaging><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><ontogeny><pathway><progenitor cell pool><progenitor cell population><progenitor pool><progenitor population><programs><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><re-epithelialization><rectal epithelium><rectal lining><rectal mucosa><rectal mucosal tissue><regenerate><regenerate epithelium><regeneration based therapy><regeneration potential><regeneration research><regeneration response><regeneration studies><regeneration therapy><regenerative cell><regenerative potential><regenerative studies><regenerative therapeutics><regenerative therapy><repair><repaired><resistant><response><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stem><stem and progenitor cell population><stem cell pool><stem cell population><stem cells><therapeutic target><transcription factor><transcriptomics><translational opportunities><translational potential><transplant><tumor><tumorigenesis><wound healing><wound recovery><wound resolution>
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Meelad Dawlaty

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$527,080
FY 2026

Project Title

Role of Tet enzymes in embryonic hematopoiesis

Grant Number:

5R01HL172730-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT The central objective of this proposal is to establish how Tet enzymes regulate the specification of blood cells from endothelial cells during embryonic hematopoiesis, and from pluripotent stem cells in vitro. During embryo- genesis, hematopoietic stem and progenitor cells (HSPCs) emerge fr...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Aorta><Apoptosis><Apoptosis Pathway><Arteries><Basal Transcription Factor><Basal transcription factor genes><Binding><Blood Cells><Blood Diseases><Blood Precursor Cell><Blood Vessel Imaging><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Cell Body><Cell Count><Cell Number><Cells><Clinical><DNA><DNA Methylation><DNA Methyltransferase><DNA Modification><DNA Modification Methylases><DNA Modification Methyltransferases><DNA Modification Process><DNA-Methyltransferases><Deoxyribonucleic Acid><Deposit><Deposition><Derivation><Derivation procedure><Development><Dioxygenases><Dnmt><Dorsal><Down-Regulation><ES cell><Embryo><Embryo Development><Embryogenesis><Embryoid bodies><Embryonic><Embryonic Development><Endothelial Cells><Endothelium><Enhancers><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Family><Fetal Liver><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><GFI-1><GFI1><GFI1 gene><GFI1A><Gene Expression><Gene Inactivation><Gene Silencing><General Transcription Factor Gene><General Transcription Factors><Genes><Goals><HSC formation><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Hypermethylation><Image Cytometry><Impairment><In Vitro><Mediating><Methylation><Mice><Mice Mammals><Modeling><Modification><Modification Methylases><Molecular><Molecular Interaction><Mouse ES Cell><Mouse ESC><Mouse Embryonic Progenitor><Mouse Embryonic Stem Cells><Murine><Mus><Mutate><Outcome><Peripheral Blood Cell><Physiology><Pluripotent Stem Cells><Process><Progenitor Cells><Programmed Cell Death><Proteins><Publishing><Regulatory Element><Reporter><Role><Site-Specific DNA-methyltransferase><Specific qualifier value><Specified><Staining method><Stains><Surface><Testing><Tet><Tetanus Helper Peptide><Transcription Factor Proto-Oncogene><Transcription factor genes><Work><Yolk Sac><adulthood><blood cell formation><blood cell progenitor><blood disorder><blood formation><blood progenitor><blood stem cell><blood stem cell formation><blood treatment><blood-forming stem cell><cell type><demethylation><developmental><differentiation of pluripotent stem cells><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><endothelial progenitor><endothelial progenitor cell><endothelial stem cell><epigenetically><flow cytophotometry><gastrulation><hematopoietic gene><hematopoietic progenitor><hematopoietic progenitor cell formation><hematopoietic progenitor formation><hematopoietic stem cell formation><hematopoietic stem progenitor cell><hemogenic endothelium><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><in vivo><mESC><mouse model><murine ES cells><murine ESC><murine embryonic progenitor><murine embryonic stem cell><murine model><novel><pluripotent progenitor><pluripotent stem cell differentiation><programs><recruit><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem cell of embryonic origin><stem cells><transcription factor><transcriptional silencing><transcriptomics><vascular imaging><vasculature Imaging><vitelline sac>
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EUN SOK KIM

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$517,805
FY 2026

Project Title

Damage-Free, Ultrasonic Cell Isolation from Retinal Pigment Epithelium (RPE) Monolayers

Grant Number:

5R01EY035281-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

2/28/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Age-related macular degeneration (AMD) is the leading cause of severe visual impairment in people over age 50 in developed countries [1,2]. Transplantation of stem cell derived retinal pigment epithelium (RPE) is currently a promising method to treat retinal degeneration and advanced non-ne...

Research Terms

<Acoustics><Age><Age related macular degeneration><Age related pathologies><Age-Related Maculopathy><Area><Atrophic><Atrophy><Biopsy><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Therapy><Cells><Cellular injury><Chromosomes><Clinical><Clinical Trials><Collection><Complex><Data><Derivation><Derivation procedure><Developed Countries><Development><Diameter><Diminished Vision><Dysfunction><Encapsulated><Epithelial Cells><Fingerprint><Focused Ultrasound><Functional disorder><Gel><Genes><Goals><Graft Rejection><Immune><Immunes><Implant><Individual><Industrialized Countries><Industrialized Nations><Interruption><Leanness><Liquid substance><Low Vision><Measures><Methods><Microbeads><Microfluidics><Microspheres><Modeling><Molecular><Molecular Analysis><Molecular Fingerprinting><Molecular Profiling><Nature><Needles><Oils><Outer pigmented layer of retina><Partial Sight><Pathology><Patients><Persons><Photoreceptor Cell><Photoreceptors><Photosensitive Cell><Physiopathology><Pigment cell layer of retina><Pigmented layer of retina><Pluripotent Stem Cells><Polymerase Chain Reaction><Population><Production><Progenitor Cell Transplantation><Progenitor Cells><Progressive Disease><Protocol><Protocols documentation><Quality Control><Radiation><Reagent><Reduced Vision><Research><Retina><Retinal Degeneration><Retinal Pigment Epithelium><Retinal pigment epithelial cells><Reverse Transcription><Shapes><Solid><Spottings><Stem Cell Transplantation><Stem cell transplant><Structure of retinal pigment epithelium><Subnormal Vision><Surface><Suspension substance><Suspensions><Technology><Temperature><Testing><Thinness><Transducers><Transfection><Transplant Rejection><Transplantation><Transplantation Rejection><Tumorigenicity><Ultrasonic><Ultrasonic Transducer><Ultrasonics><Ultrasound transducer><Variant><Variation><Visual Receptor><Visual impairment><Wound Repair><age associated pathologies><age dependent macular degeneration><age dependent pathologies><age induced macular degeneration><age induced pathologies><age related macular disease><age related macular dystrophy><ages><aging associated pathologies><aging dependent pathologies><aging induced pathologies><aging pathologies><aging related pathologies><cell based intervention><cell damage><cell injury><cell mediated intervention><cell mediated therapies><cell sorting><cell-based therapeutic><cell-based therapy><cellular damage><cellular therapeutic><cellular therapy><cost><damage to cells><degenerative retina diseases><developed country><developed nation><developed nations><developmental><epithelial to mesenchymal transition><fluid><global gene expression><global transcription profile><hESC><hiPSC><human ES cell><human ESC><human embryonic stem cell><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human progenitor><human stem cells><iPS><iPSC><iPSCs><improved><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><injury to cells><liquid><molecular profile><molecular signature><monolayer><novel><operation><operations><particle><pathophysiology><pluripotency><pluripotent progenitor><pluripotent state><pressure><prevent><preventing><progenitor transplantation><regenerative><retina degeneration><retinal degenerative><retinal degenerative diseases><scRNA sequencing><scRNA-seq><scaffold><scaffolding><senile macular disease><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial molecular analysis><spatial molecular imaging><spatial molecular mapping><spatial molecular profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stem and progenitor cell transplantations><stem cells><subretinal injection><transcriptome><transplant><ultrasound><vision impairment><visually impaired><wound healing><wound recovery><wound resolution><µfluidic>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

John Zhong

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$517,805
FY 2026

Project Title

Damage-Free, Ultrasonic Cell Isolation from Retinal Pigment Epithelium (RPE) Monolayers

Grant Number:

5R01EY035281-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

2/28/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Age-related macular degeneration (AMD) is the leading cause of severe visual impairment in people over age 50 in developed countries [1,2]. Transplantation of stem cell derived retinal pigment epithelium (RPE) is currently a promising method to treat retinal degeneration and advanced non-ne...

Research Terms

<Acoustics><Age><Age related macular degeneration><Age related pathologies><Age-Related Maculopathy><Area><Atrophic><Atrophy><Biopsy><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Therapy><Cells><Cellular injury><Chromosomes><Clinical><Clinical Trials><Collection><Complex><Data><Derivation><Derivation procedure><Developed Countries><Development><Diameter><Diminished Vision><Dysfunction><Encapsulated><Epithelial Cells><Fingerprint><Focused Ultrasound><Functional disorder><Gel><Genes><Goals><Graft Rejection><Immune><Immunes><Implant><Individual><Industrialized Countries><Industrialized Nations><Interruption><Leanness><Liquid substance><Low Vision><Measures><Methods><Microbeads><Microfluidics><Microspheres><Modeling><Molecular><Molecular Analysis><Molecular Fingerprinting><Molecular Profiling><Nature><Needles><Oils><Outer pigmented layer of retina><Partial Sight><Pathology><Patients><Persons><Photoreceptor Cell><Photoreceptors><Photosensitive Cell><Physiopathology><Pigment cell layer of retina><Pigmented layer of retina><Pluripotent Stem Cells><Polymerase Chain Reaction><Population><Production><Progenitor Cell Transplantation><Progenitor Cells><Progressive Disease><Protocol><Protocols documentation><Quality Control><Radiation><Reagent><Reduced Vision><Research><Retina><Retinal Degeneration><Retinal Pigment Epithelium><Retinal pigment epithelial cells><Reverse Transcription><Shapes><Solid><Spottings><Stem Cell Transplantation><Stem cell transplant><Structure of retinal pigment epithelium><Subnormal Vision><Surface><Suspension substance><Suspensions><Technology><Temperature><Testing><Thinness><Transducers><Transfection><Transplant Rejection><Transplantation><Transplantation Rejection><Tumorigenicity><Ultrasonic><Ultrasonic Transducer><Ultrasonics><Ultrasound transducer><Variant><Variation><Visual Receptor><Visual impairment><Wound Repair><age associated pathologies><age dependent macular degeneration><age dependent pathologies><age induced macular degeneration><age induced pathologies><age related macular disease><age related macular dystrophy><ages><aging associated pathologies><aging dependent pathologies><aging induced pathologies><aging pathologies><aging related pathologies><cell based intervention><cell damage><cell injury><cell mediated intervention><cell mediated therapies><cell sorting><cell-based therapeutic><cell-based therapy><cellular damage><cellular therapeutic><cellular therapy><cost><damage to cells><degenerative retina diseases><developed country><developed nation><developed nations><developmental><epithelial to mesenchymal transition><fluid><global gene expression><global transcription profile><hESC><hiPSC><human ES cell><human ESC><human embryonic stem cell><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human progenitor><human stem cells><iPS><iPSC><iPSCs><improved><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><injury to cells><liquid><molecular profile><molecular signature><monolayer><novel><operation><operations><particle><pathophysiology><pluripotency><pluripotent progenitor><pluripotent state><pressure><prevent><preventing><progenitor transplantation><regenerative><retina degeneration><retinal degenerative><retinal degenerative diseases><scRNA sequencing><scRNA-seq><scaffold><scaffolding><senile macular disease><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial molecular analysis><spatial molecular imaging><spatial molecular mapping><spatial molecular profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stem and progenitor cell transplantations><stem cells><subretinal injection><transcriptome><transplant><ultrasound><vision impairment><visually impaired><wound healing><wound recovery><wound resolution><µfluidic>
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Antony Rodriguez

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$515,003
FY 2026

Project Title

Delineating the role of let-7 microRNA on lung AT2 cell homeostasis, alveolar regeneration, and interstitial lung disease

Grant Number:

5R01HL167814-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Interstitial lung diseases (ILDs) including Idiopathic Pulmonary Fibrosis (IPF) are associated with significant morbidity and mortality. Treatment options for patients with ILD are limited by a lack of understanding of the pathophysiologic mechanisms. Alveolar type 2 (AT2) cells, the...

Research Terms

<AT Hooks><AT-Hook Motifs><ATAC sequencing><ATAC-seq><ATACseq><ATH><Aging><Alveolar><Alveoli progenitor><Alveoli stem cell><Alveolitis><Alveolus><Animal Model><Animal Models and Related Studies><Apoptosis><Apoptosis Pathway><Appearance><Architecture><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Autophagocytosis><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Bioenergetics><Biological Assay><Bleo><Bleomycin><Bronchial Alveolus><Cell Aging><Cell Body><Cell Compartmentation><Cell Compartmentations><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cell Survival><Cell Viability><Cells><Cellular Aging><Cellular Expansion><Cellular Function><Cellular Growth><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Cellular Senescence><Characteristics><Chronic lung disease><Collagen><Complex><DNA><Data><Defect><Deoxyribonucleic Acid><Deposit><Deposition><Development><Dysfunction><Emphysema><Engineering / Architecture><Enhancers><Ensure><Experimental Genetics><Family><Fibrosing Alveolitis><Fibrosis><Functional disorder><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genus Hippocampus><Goals><Homeostasis><Human><Hyperplasia><Hyperplastic><Hypoxemia><Immune><Immunes><Immunofluorescence><Immunofluorescence Immunologic><Impairment><Inflammation><Injury><Interstitial Lung Diseases><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Lamellar Body><Lipids><Lung><Lung Respiratory System><Lung Surfactant><Lung Tissue Fibrosis><Lung damage><Lung fibrogenesis><Lycopersicon esculentum><MYC Transcription Factor><Measurement><Metabolic><Mice><Mice Mammals><MicroRNAs><Modeling><Modern Man><Molecular><Morbidity><Murine><Mus><Natural regeneration><Nodal><Null Mouse><Organelles><Pathogenicity><Pathway interactions><Patients><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Play><Pluripotent Stem Cells><Polycomb><Process><Progenitor Cells><Programmed Cell Death><Proliferating><Proteins><Proto-Oncogene Products c-myc><Proto-Oncogene Proteins c-myc><Public Health><Pulmonary Emphysema><Pulmonary Fibrosis><Pulmonary Surfactants><Pulmonary fibrogenesis><Quality Control><Regeneration><Regulation><Replicative Senescence><Repression><Research><Resolution><Role><Seahorse><Solanum lycopersicum><Somatic Cell><Stress><Subcellular Process><System><Testing><Time><Tissue Model><Tomatoes><Tracer><Transcription Factor Proto-Oncogene><Transcription factor genes><Transitional Cell><Upstream Enhancer><Work><age associated><age correlated><age dependent><age linked><age related><age specific><alveolar lamellar body><alveolar progenitor><alveolar stem cell><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><autophagy><c-myc Proteins><cell growth><cell metabolism><cellular differentiation><cellular metabaolism><chronic pulmonary disease><developmental><diffuse interstitial pulmonary fibrosis><disease diagnosis><drug discovery><effective therapy><effective treatment><emphysematous><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><fat metabolism><fibrosis in the lung><healing><human tissue><hypoxemic><idiopathic pulmonary fibrosis><improved><in vivo><injuries><insight><lipid metabolism><lung fibrosis><lung injury><miRNA><model of animal><mortality><mouse model><murine model><myc Proto-Oncogene Product p62><myc Proto-Oncogene Proteins><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathophysiology><pathway><pluripotent progenitor><prevent><preventing><progenitor><progenitor cell division><progenitor cell fate><progenitor cell pool><progenitor cell population><progenitor cell renewal><progenitor division><progenitor fate><progenitor pool><progenitor population><progenitor renewal><programs><pulmonary><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><regenerate><repair><repaired><replicative aging><resolutions><response><scRNA sequencing><scRNA-seq><senescence><senescent><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem><stem and progenitor cell division><stem and progenitor cell fate><stem and progenitor cell population><stem and progenitor cell renewal><stem cell division><stem cell fate><stem cell pool><stem cell population><stem cell renewal><stem cells><surfactant><surfactant production><tissue repair><transcription factor><transcriptomics><transdifferentiation>
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Jamy C. Peng

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$508,750
FY 2026

Project Title

Epigenetic gene regulation for stem cell fates

Grant Number:

5R35GM158393-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/5/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT In stem cells, the interactions among transcription circuitry, extrinsic and intrinsic signaling pathways, and epigenetic modifiers lead to transcriptional outputs that direct different cell fates. These cell fates include self- renewal, cell differentiation, and cell death. These remarkabl...

Research Terms

<21+ years old><53BP1><ATM Protein><ATM Serine/Threonine Protein Kinase><ATM kinase><ATM protein kinase><Adult><Adult Human><Ataxia Telangiectasia Mutated><Ataxia Telangiectasia Protein><Ataxia-Telangiectasia-Mutated protein kinase><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Body Tissues><Cancers><Cell Body><Cell Death><Cell Differentiation><Cell Differentiation process><Cell Fate Control><Cell Fate Regulation><Cells><Cellular Expansion><Cellular Growth><Childhood><Childhood Cancers><Childhood Glioma><Chromatin><Cues><DNA Damage><DNA Injury><Defect><Dependence><Development><Developmental Gene><Disease><Disorder><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Experimental Models><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genetic Transcription><Grips><Growth><Histone H3><Homeostasis><Human><Human Development><Knowledge><L-Lysine><Lead><Lysine><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Neoplasms><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant Tumor><Malignant childhood cancer><Methylation><Modern Man><Output><Patients><Pb element><Pediatric Glioma><Pediatric high-grade glioma><Phenotype><Physiological Homeostasis><Pluripotent Stem Cells><Progenitor Cells><Property><Proteins><RNA Expression><Research><Sight><Signal Pathway><Specific qualifier value><Specified><TP53BP1><Testing><Tissue Growth><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Translating><Vision><adulthood><ataxia telangiectasia mutated protein><cancer in a child><cancer in children><cell growth><cell type><cellular differentiation><child with cancer><childhood malignancy><demethylation><developmental><developmental disease><developmental disorder><disease model><disorder model><epigenetic regulation><epigenetically><grasp><heavy metal Pb><heavy metal lead><human disease><human embryogenesis><human embryonic development><injury and repair><insight><malignancy><necrocytosis><neoplasm/cancer><neural><ontogeny><p202><p53-binding protein 1><p53BP1><pediatric><pediatric cancer><pediatric malignancy><pluripotent progenitor><progenitor biology><progenitor cell biology><progenitor cell fate><progenitor cell model><progenitor fate><progenitor model><programs><promoter><promotor><response><self-renew><self-renewal><stem and progenitor biology><stem and progenitor cell fate><stem and progenitor cell model><stem cell based model><stem cell biology><stem cell derived model><stem cell fate><stem cell model><stem cells><success><synergism><transcription factor><visual function>
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Chen Zhao

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$502,516
FY 2026

Project Title

Targeting Leukemia Stem Cells with Small Molecule Heat Shock Transcription Factor 1 Degrader

Grant Number:

5R01CA292487-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary_Abstract Acute myeloid leukemia (AML) thrives through the persistence of self-renewing leukemic stem cells (LSCs). A central challenge in AML treatment lies in the failure of conventional therapies to eradicate LSCs, which can trigger AML reoccurrence. The promise of AML eradication ...

Research Terms

<AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Affect><Apoptosis><Apoptosis Pathway><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Binding><Biological Markers><Blood Precursor Cell><CCAAT-Box Binding Transcription Factor><Cancer Model><CancerModel><Cell Body><Cell Communication and Signaling><Cell Death Induction><Cell Signaling><Cells><Cellular Stress><Cellular Stress Response><Classification><Clinical><Clinical Markers><Clinical Trials><DNA><Data><Deoxyribonucleic Acid><Development><Disease><Disease remission><Disorder><Drugs><Energy Expenditure><Energy Metabolism><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exhibits><Failure><General Transcription Factor Gene><General Transcription Factors><Genes><Heat shock proteins><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterograft><Heterologous Transplantation><Human><Immune><Immune Evasion><Immune Surveillance><Immunes><Immunologic Surveillance><Immunosurveillance><Impairment><Intracellular Communication and Signaling><KO mice><Knock-out Mice><Knockout Mice><Lead><Leukemic progenitor and stem cell><MLL-AF9><MLL/AF9 AML><Malignant Cell><Measures><Medication><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Molecular Interaction><Monitor><Murine><Mus><Mutate><NF-I Protein><NFI Transcription Factor><Nuclear><Nuclear Factor I><Null Mouse><Oncogenic><Outcome Study><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Pathway interactions><Patients><Pb element><Pharmaceutical Preparations><Population><Predisposition><Prognosis><Programmed Cell Death><Proliferating><Property><Protein Biosynthesis><Publishing><Relapse><Remission><Research><Resistance><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Role><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Stem Cell like><Stress><Susceptibility><Systematics><T-Cells><T-Lymphocyte><TCGA><Testing><The Cancer Genome Atlas><Therapeutic><Transcription Factor Proto-Oncogene><Transcription factor genes><Translations><Xenograft><Xenograft procedure><Xenotransplantation><acute granulocytic leukemia><acute myeloid leukemia><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker identification><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cancer cell><cell stress><chemotherapeutic agent><chemotherapeutic compounds><chemotherapeutic drugs><chemotherapeutic medications><chemotherapy><clinical biomarkers><clinically useful biomarkers><conventional therapy><conventional treatment><developmental><driving><drug/agent><epigenetically><experience><heat shock transcription factor><heavy metal Pb><heavy metal lead><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><identification of biomarkers><identification of new biomarkers><immune evasive><inhibitor><knock-down><knockdown><leukemia stem/initiating cells><leukemia treatment><leukemic progenitor><leukemic stem cell><leukemic therapy><marker identification><mitochondrial><novel><nuclear factor 1><pathway><progenitor capacity><progenitor cell function><progenitor cell like><progenitor cell maintenance><progenitor cell proliferation><progenitor cell regeneration><progenitor cell self renewal><progenitor function><progenitor maintenance><progenitor proliferation><progenitor regeneration><progenitor self renewal><progenitor-like><protein synthesis><resistance mechanism><resistant><resistant mechanism><response to therapy><response to treatment><self-renew><self-renewal><small molecule><social role><stem and progenitor cell function><stem and progenitor cell proliferation><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor function><stem cell characteristics><stem cell function><stem cell maintenance><stem cell proliferation><stem cell regeneration><stem cell self renewal><stem-like><stemness><stress buffering><stress management><stress protein><therapeutic response><therapeutic target><therapy response><thymus derived lymphocyte><transcription factor><translation><treatment response><treatment responsiveness><xeno-transplant><xeno-transplantation>
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Rui Yi

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$500,821
FY 2026

Project Title

Transcriptional regulation of skin stem cells and their niche

Grant Number:

5R01AR071435-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/28/2017

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary: The overarching goal of the proposed research is to understand the mechanism of hair follicle stem cell (HF-SC) maintenance and aging. HF-SCs reside in an anatomically distinct region, called the bulge. During the lifespan, HF-SCs go through a multi-stage process, called the hair c...

Research Terms

<AP-1><AP-1 Enhancer-Binding Protein><AP1><AP1 protein><Activator Protein-1><Affect><Aging><Anatomic Sites><Anatomic structures><Anatomy><Apoptosis><Apoptosis Pathway><Architecture><Atlases><Autoregulation><Binding><Biologic Models><Biological Models><Body Tissues><Cell Adhesion><Cell Aging><Cell Body><Cell Compartmentation><Cell Compartmentations><Cell Junctions><Cell Locomotion><Cell Migration><Cell Movement><Cell Senescence><Cell Survival><Cell Viability><Cell-Extracellular Matrix><Cells><Cellular Adhesion><Cellular Aging><Cellular Migration><Cellular Motility><Cellular Senescence><Chromatin><Corium><Cutis><Data Set><Dermis><Docking><ECM><Engineering / Architecture><Enhancer-Binding Protein AP1><Epithelium><Extracellular Matrix><FKHL7><FOXC1><FOXC1 gene><FREAC3><Forkhead Box C1><Forkhead, Drosophila, Homolog-Like 7><Forkhead-Related Activator 3><Funding><GEM model><GEMM model><Gene Expression><Generalized Growth><Genetic study><Genetically Engineered Mouse><Genome><Germ><Goals><Growth><Hair><Hair Bulb><Hair Follicle><Hair bulb structure><Hair follicle structure><Hair shaft structure><Homeostasis><Image><Impairment><Individual><Intercellular Junctions><Knock-out><Knockout><Knowledge><Maintenance><Mammalia><Mammals><Mediating><Miniaturisations><Miniaturization><Model System><Modeling><Molecular><Molecular Interaction><Pattern><Phase><Physiological Homeostasis><Population><Premature Aging><Premature aging syndrome><Process><Progenitor Cells><Programmed Cell Death><Property><Regenerative Medicine><Replicative Senescence><Research><Resolution><Rest><Site><Skin><Specific qualifier value><Specified><Testing><Tissue Growth><Tissues><Transcription Factor AP-1><Transcriptional Control><Transcriptional Regulation><Transmission><adult progenitor><adult stem cell><aged><cell motility><cell type><cutaneous stem cells><decline in function><decline in functional status><dermal progenitor><dermal stem cell><exhaustion><functional decline><functional status decline><genetically engineered mouse model><genetically engineered murine model><genomic tools><global gene expression><global transcription profile><hair shaft><hallmarks of aging><imaging><innovate><innovation><innovative><insight><intra-vital imaging><intravital imaging><life span><lifespan><migration><migratory population><mouse model><murine model><mutant><next generation><novel><ontogeny><pillars of aging><progenitor><progenitor cell maintenance><progenitor cell niche><progenitor maintenance><progenitor niche><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><replicative aging><resolutions><scRNA sequencing><scRNA-seq><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell transcriptomic profiling><single-cell RNA sequencing><skin progenitor><skin stem cell><somatic progenitor><somatic stem cell><spatial and temporal><spatial temporal><spatiotemporal><stem and progenitor cell niche><stem cell maintenance><stem cell niche><stem cells><tissue progenitor><tissue regeneration><tissue regrowth><tissue renewal><tissue specific progenitor cells><tissue specific regeneration><tissue specific stem cells><tissue stem cells><transcriptome><transcriptomics><transmission process>
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Jeremy Purvis

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$1,219,740
FY 2026

Project Title

Computational Models of the Human Cell Cycle to Reveal Disease Mechanism and Inform Treatment

Grant Number:

2R01GM138834-05A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/11/2020

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

2R01-GM138834 COMPUTATIONAL MODELS OF THE HUMAN CELL CYCLE PROJECT SUMMARY / ABSTRACT The long-term goal of this project is to build computational models of the human cell cycle that advance our knowledge of the basic mechanisms driving cell cycle progression and arrest. This renewal focuses specif...

Research Terms

<Aging><Area><Automobile Driving><Autoregulation><Basic Research><Basic Science><Behavior><Biologic Sciences><Biological><Biological Function><Biological Process><Biological Sciences><Biomedical Research><Bioscience><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Cycle Arrest><Cell Cycle Checkpoint><Cell Cycle Control><Cell Cycle Progression><Cell Cycle Regulation><Cell Cycle Stage><Cell Division Cycle><Cell Signaling><Cell division><Cell model><Cells><Cellular Expansion><Cellular Growth><Cellular biology><Cellular injury><Cellular model><Chemicals><Clinical><Co-culture><Cocultivation><Coculture><Coculture Techniques><Computational toolkit><Computer Models><Computerized Models><DNA Damage><DNA Injury><Data><Development><Disease><Disorder><ES cell><Ectoderm><Embryo Development><Embryogenesis><Embryonic Development><Endoderm><Environment><Epithelial Cells><Experimental Models><Funding><Genetic><Germ Layers><Goals><Graph><Homeostasis><Human><Human Development><Image><Individual><Intracellular Communication and Signaling><Knowledge><Life Sciences><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measurement><Mediating><Mesoderm><Methods><Microscopy><Modeling><Modern Man><Molecular><Nature><Neighborhoods><Phase><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Play><Principal Component Analyses><Principal Component Analysis><Probabilistic Models><Probability Models><Proliferating><Regenerative Medicine><Research><Role><Science><Side><Signal Transduction><Signal Transduction Systems><Signaling><Somatic Cell><Statistical Methods><Statistical Models><Stress><Techniques><Testing><Tissues><Translational Research><Translational Science><Tumor Cell><Variant><Variation><Visualization><Wound Repair><behavior change><biologic><biological signal transduction><cell behavior><cell biology><cell cycle check point><cell damage><cell growth><cell imaging><cell injury><cell type><cellular behavior><cellular damage><cellular imaging><computational modeling><computational models><computational toolbox><computational tools><computational toolset><computer based models><computer based prediction><computerized modeling><computerized tools><damage to cells><data-driven model><developmental><driving><effective therapy><effective treatment><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><flexibility><flexible><hESC><human ES cell><human ESC><human disease><human embryonic stem cell><human model><human progenitor><human stem cells><imaging><injury to cells><innovate><innovation><innovative><insight><model of human><model-based simulation><models and simulation><neoplastic cell><pharmacologic><predictive modeling><progenitor cell differentiation><progenitor cell fate><progenitor differentiation><progenitor fate><programs><senescence><senescent><senescent cell><single cell analysis><social role><statistic methods><statistical linear mixed models><statistical linear models><stem and progenitor cell fate><stem and progenitor differentiation><stem cell differentiation><stem cell fate><stem cell of embryonic origin><success><translation research><translational investigation><wound healing><wound recovery><wound resolution>
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Christopher Michael Sturgeon

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$1,175,924
FY 2026

Project Title

Hemogenic mesoderm heterogeneity, regulation, and function

Grant Number:

1R35HL184269-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2033

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY / ABSTRACT The mammalian hematopoietic system develops in the early embryo through a series of spatio-temporally separated programs, each of which harbors different functional potential, culminating in the specification of the hematopoietic stem cell (HSC). The overall goal of our re...

Research Terms

<21+ years old><Adult><Adult Human><Biology><Blood><Blood Cells><Blood Precursor Cell><Blood Reticuloendothelial System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clinical><Development><Embryo><Embryonic><Endothelial Cells><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Erythro><Gene Transcription><Generations><Genes><Genetic Transcription><Goals><HSC Specification><Hematologic Body System><Hematologic Organ System><Hematopoietic><Hematopoietic Body System><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Specification><Hematopoietic System><Hematopoietic stem cells><Heterogeneity><Human><Immunologic Subtyping><Immunophenotyping><In Vitro><Intracellular Communication and Signaling><Mesoderm><Modern Man><Molecular><Multipotent Stem Cells><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><Patients><Peripheral Blood Cell><Population><Process><Production><Productivity><Property><RNA Expression><Regenerative Medicine><Regulation><Research><Series><Signal Transduction><Signal Transduction Systems><Signaling><Specific qualifier value><Specified><System><Transcription><VEGF><VEGFs><Vascular Endothelial Growth Factors><Work><Yolk Sac><adulthood><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cell type><developmental><directed differentiation><embryo cell><epigenetically><gastrulation><hematopoietic progenitor><hematopoietic stem progenitor cell><hemogenic endothelium><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><human derived pluripotent stem cell><human pluripotent stem cell><improved><insight><lens><lenses><multipotent progenitor><multipotent progenitor cell><myeloid precursor><myeloid stem and progenitor cell><progenitor><programs><spatial and temporal><spatial temporal><spatiotemporal><tech development><technology development><translational opportunities><translational potential><vitelline sac>
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Daniel Lucas

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

High-opportunity lead · 72/100
Likely hiring
Large award
Recent
Active award
$1,044,609
FY 2026

Project Title

The microenvironment in bone marrow hematopoiesis

Grant Number:

5R35HL177125-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Abstract: Blood cell production takes place via stepwise differentiation from hematopoietic stem cells into multipotent progenitors that give rise to unipotent progenitors responsible for producing each of the major blood cell lineages (lymphocytes, monocytes, neutrophils, and red blood cells). This...

Research Terms

<Anatomic Sites><Anatomic structures><Anatomy><Area><Autoregulation><Blood><Blood Cells><Blood Diseases><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood Precursor Cell><Blood Reticuloendothelial System><Blood Vessels><Blood erythrocyte><Blood monocyte><Body System><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Lineage><Cell Signaling><Cells><Cues><Discontinuous Capillary><Disease><Disorder><Dysfunction><Engraftment><Erythrocytes><Erythrocytic><Erythroid Precursor Cells><Erythroid Progenitor Cells><Erythroid Stem Cells><Erythropoietic Progenitor Cells><Erythropoietic Stem Cells><Functional disorder><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Homeostasis><Inflammation><Inflammatory><Intracellular Communication and Signaling><Lymphatic cell><Lymphocyte><Lymphocytic><Marrow Neutrophil><Marrow erythrocyte><Marrow monocyte><Molecular><Multipotent Stem Cells><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><Natural regeneration><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Organ System><Peripheral Blood Cell><Physiological Homeostasis><Physiology><Physiopathology><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Process><Production><Recovery><Red Blood Cells><Red Cell><Regeneration><Research><Signal Transduction><Signal Transduction Systems><Signaling><Sinusoid><Sinusoidal Capillary><Stress><Structure><System><Testing><Tissues><Transplantation><biological signal transduction><blood cell formation><blood cell progenitor><blood corpuscles><blood disorder><blood progenitor><blood stem cell><blood-forming stem cell><bone><cellular differentiation><design><designing><erythroid progenitor><erythroid-committed progenitors><hematopoietic differentiation><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><imaging approach><imaging based approach><imaging genetics><lymph cell><monocyte><mouse genetics><multipotent progenitor><multipotent progenitor cell><myeloid precursor><myeloid stem and progenitor cell><neutrophil><pathophysiology><progenitor><programs><recruit><regenerate><regenerative><transplant><vascular>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Max Brenner

FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, MANHASSET, NY

Good lead · 68/100
Likely hiring
Above-average budget
Active award
Team-scale grant
$586,240
FY 2026

Project Title

Ghrelin as Radiation Countermeasure: Mechanism of Its Action

Grant Number:

5U01AI186997-02

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/5/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT DESCRIPTION: This U01 project aims to elucidate a novel neuroenteric mechanism through which ghrelin confers intestinal radioprotection, and to preclinically develop human ghrelin as a safe and effective mitigator for gastrointestinal acute radiation syndrome (GI-ARS). Ghrelin is a small pep...

Research Terms

<ACh Receptors><Acetylcholine Receptors><Acute Radiation Syndrome><Amino Acids><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Apoptosis><Apoptosis Pathway><Apoptotic><Attenuated><BBB crossing><Bacterial Translocation><Blood><Blood Reticuloendothelial System><Blood Serum><Body System><CNS Nervous System><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Central Nervous System><Cholinergic Receptors><Cholinoceptive Sites><Cholinoceptors><Citrulline><Cranial Nerve X><Denervation><Dose><Dropsy><Dysfunction><Early-Stage Clinical Trials><Edema><Emergencies><Emergency Situation><Endotoxins><Enteric Nervous System><Enterocytes><Exposure to><FDA approved><Filgrastim SD-01><Functional disorder><GI Stem cell><Gene Expression><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><HG38><Histologic><Histologically><Human><Hydration><Hydration status><Hydrops><Individual><Inflammatory><Injury><Intestinal><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Ionizing Electromagnetic Radiation><Ionizing radiation><LGR5><LGR5 gene><Length><MAC393 antigen><Mediating><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Murine><Mus><Neulasta><Neuranatomies><Neuranatomy><Neuraxis><Neuroanatomies><Neuroanatomy><Organ System><Organoids><PEG SD-01><PEG-rmetHuG-CSF><Pegfilgrastim><Peptides><Permeability><Pharmacology><Phase 1 Clinical Trials><Phase I Clinical Trials><Physiopathology><Pneumogastric Nerve><Progenitor Cells><Programmed Cell Death><Radiation><Radiation Dose><Radiation Dose Unit><Radiation Injuries><Radiation Protection><Radiation Toxicity><Radiation exposure><Radiation-Ionizing Total><Radioprotection><Radioprotective><Radiotoxicity><Recovery><Regulation><Reserve Cell><Rodent><Rodentia><Rodents Mammals><Role><SD-01><SD-01 sustained duration G-CSF><SGP-2 protein><SGP2><SP 40,40 protein><Safety><Sampling><Serum><Severities><Stomach><Subcutaneous Injections><Survival Rate><TRPM-2 protein><TRPM2><Tenth Cranial Nerve><Therapeutic><Total Body Irradiation><Vagotomy><Vagus Nerve><Vagus nerve structure><Villus><Whole-Body Irradiation><Whole-Body Radiation><X-ray-inducible protein 8><XIP8 protein><aminoacid><apoJ protein><apolipoprotein J><attenuate><attenuates><blood-brain barrier crossing><bloodbrain barrier crossing><bowel><bowel inflammation><cell sorting><cholinergic><cholinergic synapse><clusterin><complement lysis inhibitor><complement-associated protein SP-40,40 protein><effective therapy><effective treatment><gastric><gastrointestinal><gastrointestinal stem cell><ghrelin><gut inflammation><gut progenitor><gut stem cell><healing><improved><in vivo><inflamed bowel><inflamed gut><inflamed intestine><injuries><insight><intestinal crypt><intestinal epithelium><intestinal inflammation><intestinal progenitor><intestinal stem cells><ionizing output><ionizing radiation-induced protein-8><irradiation><irradiation injury><medical countermeasure><model of animal><mortality><novel><pathophysiology><phase I protocol><polyethylene glycol-conjugated filgrastim SD-01><pre-clinical><preclinical><progenitor cell expansion><progenitor expansion><protective effect><public health relevance><radiation countermeasure><radiation mitigation><radiation mitigator><radiation poisoning><radio-protection><radio-protective><radiological countermeasure><radiological mitigation><radiological mitigator><radiomitigation><radiomitigator><radioprotected><response><social role><standard of care><stem and progenitor cell expansion><stem cell expansion><stem cells><subdermal injection><sulfated glycoprotein 2><testosterone-repressed prostate message-2 protein><vagus nerve stimulation>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Asha Varghese

FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, MANHASSET, NY

Good lead · 68/100
Likely hiring
Above-average budget
Active award
Team-scale grant
$586,240
FY 2026

Project Title

Ghrelin as Radiation Countermeasure: Mechanism of Its Action

Grant Number:

5U01AI186997-02

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/5/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT DESCRIPTION: This U01 project aims to elucidate a novel neuroenteric mechanism through which ghrelin confers intestinal radioprotection, and to preclinically develop human ghrelin as a safe and effective mitigator for gastrointestinal acute radiation syndrome (GI-ARS). Ghrelin is a small pep...

Research Terms

<ACh Receptors><Acetylcholine Receptors><Acute Radiation Syndrome><Amino Acids><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Apoptosis><Apoptosis Pathway><Apoptotic><Attenuated><BBB crossing><Bacterial Translocation><Blood><Blood Reticuloendothelial System><Blood Serum><Body System><CNS Nervous System><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Central Nervous System><Cholinergic Receptors><Cholinoceptive Sites><Cholinoceptors><Citrulline><Cranial Nerve X><Denervation><Dose><Dropsy><Dysfunction><Early-Stage Clinical Trials><Edema><Emergencies><Emergency Situation><Endotoxins><Enteric Nervous System><Enterocytes><Exposure to><FDA approved><Filgrastim SD-01><Functional disorder><GI Stem cell><Gene Expression><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><HG38><Histologic><Histologically><Human><Hydration><Hydration status><Hydrops><Individual><Inflammatory><Injury><Intestinal><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Ionizing Electromagnetic Radiation><Ionizing radiation><LGR5><LGR5 gene><Length><MAC393 antigen><Mediating><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Murine><Mus><Neulasta><Neuranatomies><Neuranatomy><Neuraxis><Neuroanatomies><Neuroanatomy><Organ System><Organoids><PEG SD-01><PEG-rmetHuG-CSF><Pegfilgrastim><Peptides><Permeability><Pharmacology><Phase 1 Clinical Trials><Phase I Clinical Trials><Physiopathology><Pneumogastric Nerve><Progenitor Cells><Programmed Cell Death><Radiation><Radiation Dose><Radiation Dose Unit><Radiation Injuries><Radiation Protection><Radiation Toxicity><Radiation exposure><Radiation-Ionizing Total><Radioprotection><Radioprotective><Radiotoxicity><Recovery><Regulation><Reserve Cell><Rodent><Rodentia><Rodents Mammals><Role><SD-01><SD-01 sustained duration G-CSF><SGP-2 protein><SGP2><SP 40,40 protein><Safety><Sampling><Serum><Severities><Stomach><Subcutaneous Injections><Survival Rate><TRPM-2 protein><TRPM2><Tenth Cranial Nerve><Therapeutic><Total Body Irradiation><Vagotomy><Vagus Nerve><Vagus nerve structure><Villus><Whole-Body Irradiation><Whole-Body Radiation><X-ray-inducible protein 8><XIP8 protein><aminoacid><apoJ protein><apolipoprotein J><attenuate><attenuates><blood-brain barrier crossing><bloodbrain barrier crossing><bowel><bowel inflammation><cell sorting><cholinergic><cholinergic synapse><clusterin><complement lysis inhibitor><complement-associated protein SP-40,40 protein><effective therapy><effective treatment><gastric><gastrointestinal><gastrointestinal stem cell><ghrelin><gut inflammation><gut progenitor><gut stem cell><healing><improved><in vivo><inflamed bowel><inflamed gut><inflamed intestine><injuries><insight><intestinal crypt><intestinal epithelium><intestinal inflammation><intestinal progenitor><intestinal stem cells><ionizing output><ionizing radiation-induced protein-8><irradiation><irradiation injury><medical countermeasure><model of animal><mortality><novel><pathophysiology><phase I protocol><polyethylene glycol-conjugated filgrastim SD-01><pre-clinical><preclinical><progenitor cell expansion><progenitor expansion><protective effect><public health relevance><radiation countermeasure><radiation mitigation><radiation mitigator><radiation poisoning><radio-protection><radio-protective><radiological countermeasure><radiological mitigation><radiological mitigator><radiomitigation><radiomitigator><radioprotected><response><social role><standard of care><stem and progenitor cell expansion><stem cell expansion><stem cells><subdermal injection><sulfated glycoprotein 2><testosterone-repressed prostate message-2 protein><vagus nerve stimulation>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

PING WANG

FEINSTEIN INSTITUTE FOR MEDICAL RESEARCH, MANHASSET, NY

Good lead · 68/100
Likely hiring
Above-average budget
Active award
Team-scale grant
$586,240
FY 2026

Project Title

Ghrelin as Radiation Countermeasure: Mechanism of Its Action

Grant Number:

5U01AI186997-02

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/5/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT DESCRIPTION: This U01 project aims to elucidate a novel neuroenteric mechanism through which ghrelin confers intestinal radioprotection, and to preclinically develop human ghrelin as a safe and effective mitigator for gastrointestinal acute radiation syndrome (GI-ARS). Ghrelin is a small pep...

Research Terms

<ACh Receptors><Acetylcholine Receptors><Acute Radiation Syndrome><Amino Acids><Animal Model><Animal Models and Related Studies><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Apoptosis><Apoptosis Pathway><Apoptotic><Attenuated><BBB crossing><Bacterial Translocation><Blood><Blood Reticuloendothelial System><Blood Serum><Body System><CNS Nervous System><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Central Nervous System><Cholinergic Receptors><Cholinoceptive Sites><Cholinoceptors><Citrulline><Cranial Nerve X><Denervation><Dose><Dropsy><Dysfunction><Early-Stage Clinical Trials><Edema><Emergencies><Emergency Situation><Endotoxins><Enteric Nervous System><Enterocytes><Exposure to><FDA approved><Filgrastim SD-01><Functional disorder><GI Stem cell><Gene Expression><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><HG38><Histologic><Histologically><Human><Hydration><Hydration status><Hydrops><Individual><Inflammatory><Injury><Intestinal><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Ionizing Electromagnetic Radiation><Ionizing radiation><LGR5><LGR5 gene><Length><MAC393 antigen><Mediating><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Murine><Mus><Neulasta><Neuranatomies><Neuranatomy><Neuraxis><Neuroanatomies><Neuroanatomy><Organ System><Organoids><PEG SD-01><PEG-rmetHuG-CSF><Pegfilgrastim><Peptides><Permeability><Pharmacology><Phase 1 Clinical Trials><Phase I Clinical Trials><Physiopathology><Pneumogastric Nerve><Progenitor Cells><Programmed Cell Death><Radiation><Radiation Dose><Radiation Dose Unit><Radiation Injuries><Radiation Protection><Radiation Toxicity><Radiation exposure><Radiation-Ionizing Total><Radioprotection><Radioprotective><Radiotoxicity><Recovery><Regulation><Reserve Cell><Rodent><Rodentia><Rodents Mammals><Role><SD-01><SD-01 sustained duration G-CSF><SGP-2 protein><SGP2><SP 40,40 protein><Safety><Sampling><Serum><Severities><Stomach><Subcutaneous Injections><Survival Rate><TRPM-2 protein><TRPM2><Tenth Cranial Nerve><Therapeutic><Total Body Irradiation><Vagotomy><Vagus Nerve><Vagus nerve structure><Villus><Whole-Body Irradiation><Whole-Body Radiation><X-ray-inducible protein 8><XIP8 protein><aminoacid><apoJ protein><apolipoprotein J><attenuate><attenuates><blood-brain barrier crossing><bloodbrain barrier crossing><bowel><bowel inflammation><cell sorting><cholinergic><cholinergic synapse><clusterin><complement lysis inhibitor><complement-associated protein SP-40,40 protein><effective therapy><effective treatment><gastric><gastrointestinal><gastrointestinal stem cell><ghrelin><gut inflammation><gut progenitor><gut stem cell><healing><improved><in vivo><inflamed bowel><inflamed gut><inflamed intestine><injuries><insight><intestinal crypt><intestinal epithelium><intestinal inflammation><intestinal progenitor><intestinal stem cells><ionizing output><ionizing radiation-induced protein-8><irradiation><irradiation injury><medical countermeasure><model of animal><mortality><novel><pathophysiology><phase I protocol><polyethylene glycol-conjugated filgrastim SD-01><pre-clinical><preclinical><progenitor cell expansion><progenitor expansion><protective effect><public health relevance><radiation countermeasure><radiation mitigation><radiation mitigator><radiation poisoning><radio-protection><radio-protective><radiological countermeasure><radiological mitigation><radiological mitigator><radiomitigation><radiomitigator><radioprotected><response><social role><standard of care><stem and progenitor cell expansion><stem cell expansion><stem cells><subdermal injection><sulfated glycoprotein 2><testosterone-repressed prostate message-2 protein><vagus nerve stimulation>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Daniel Irimia

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$817,016
FY 2026

Project Title

In vivo Monitoring of Neutrophil Function in Patients after Stem Cell Transplant

Grant Number:

5R01AI176658-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/13/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Hematopoietic stem cell transplant (HSCT), an essential procedure in the treatment of patients with hematological malignancies, also temporarily increases the risk for infections with invasive fungi. The recovery in the neutrophil number after HSCT is commonly regarded as a key metric for the restor...

Research Terms

<Acceleration><Address><Azoles><Biological Markers><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood leukocyte><C albicans><C auris><C. albicans><C. auris><C. glabrata><C.albicans><CSF3><CSF3 gene><Cancers><Candida><Candida albicans><Candida auris><Candida glabrata><Candidiasis><Candidosis><Cell Body><Cells><Chemotactic Cytokines><Communication><Diagnosis><Dysfunction><Early Diagnosis><Effectiveness><Engineering><Enrollment><Functional disorder><Fungal Drug Resistance><Fungus Diseases><Fungus drug resistant><Future><G-CSF><GCSF><Generalized Growth><Goals><Growth><HSC transplantation><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Homologous Chemotactic Cytokines><Hospital Admission><Hospitalization><Human><Hyphae><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Immune response><In Vitro><Individual><Infection><Injury><Intercrines><Knowledge><Label><Leukocytes><Leukocytes Reticuloendothelial System><Life><MGC45931><Malignant Hematologic Neoplasm><Malignant Neoplasms><Malignant Tumor><Marrow Neutrophil><Marrow leukocyte><Measurement><Measures><Microscopic><Modern Man><Molecular><Monilia><Moniliasis><Monitor><Morbidity><Mycoses><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Outcome><Patients><Performance><Phagocytosis><Physiopathology><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Predisposition><Procedures><Progenitor Cell Transplantation><Prophylactic treatment><Prophylaxis><Recovery><Research><Resistance><Risk><Risk Estimate><Risk Factors><Risk Reduction><Role><SIS cytokines><Site><Stem Cell Transplantation><Stem cell transplant><Susceptibility><Techniques><Therapeutic><Therapeutic Fungicides><Time><Tissue Growth><Torulopsis glabrata><Transplant Recipients><Transplantation><White Blood Cells><White Cell><accurate diagnosis><anti-fungal><anti-fungal agents><anti-fungal drug><anti-fungal drug resistance><anti-fungal drug resistant><anti-fungal resistance><anti-fungal resistant><bio-markers><biologic marker><biomarker><blood stem cell transplantation><candidaemia><candidemia><chemoattractant cytokine><chemokine><cytokine><design><designing><early detection><enroll><first responder><functional restoration><fungal infection><fungus><fungus drug resistance><fungus infection><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><high risk><host response><human imaging><imaging><immune system response><immunoresponse><improved><improved outcome><in vivo><in vivo monitoring><infection risk><injuries><injury to tissue><leukemia><malignancy><mortality><neoplasm/cancer><neutrophil><novel imaging technology><ontogeny><pathophysiology><patient stratification><post-transplant><post-transplantation><posttransplant><posttransplantation><progenitor transplantation><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resistance to anti-fungal><resistant><resistant to anti-fungal><restoration><restore function><restore functionality><restore lost function><risk-reducing><social role><stem and progenitor cell transplantations><stratified patient><tissue injury><tool><transplant><transplant patient><white blood cell><white blood corpuscle><yeast infection>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Charles P. Lin

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$817,016
FY 2026

Project Title

In vivo Monitoring of Neutrophil Function in Patients after Stem Cell Transplant

Grant Number:

5R01AI176658-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/13/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Hematopoietic stem cell transplant (HSCT), an essential procedure in the treatment of patients with hematological malignancies, also temporarily increases the risk for infections with invasive fungi. The recovery in the neutrophil number after HSCT is commonly regarded as a key metric for the restor...

Research Terms

<Acceleration><Address><Azoles><Biological Markers><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood leukocyte><C albicans><C auris><C. albicans><C. auris><C. glabrata><C.albicans><CSF3><CSF3 gene><Cancers><Candida><Candida albicans><Candida auris><Candida glabrata><Candidiasis><Candidosis><Cell Body><Cells><Chemotactic Cytokines><Communication><Diagnosis><Dysfunction><Early Diagnosis><Effectiveness><Engineering><Enrollment><Functional disorder><Fungal Drug Resistance><Fungus Diseases><Fungus drug resistant><Future><G-CSF><GCSF><Generalized Growth><Goals><Growth><HSC transplantation><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Homologous Chemotactic Cytokines><Hospital Admission><Hospitalization><Human><Hyphae><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Immune response><In Vitro><Individual><Infection><Injury><Intercrines><Knowledge><Label><Leukocytes><Leukocytes Reticuloendothelial System><Life><MGC45931><Malignant Hematologic Neoplasm><Malignant Neoplasms><Malignant Tumor><Marrow Neutrophil><Marrow leukocyte><Measurement><Measures><Microscopic><Modern Man><Molecular><Monilia><Moniliasis><Monitor><Morbidity><Mycoses><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Outcome><Patients><Performance><Phagocytosis><Physiopathology><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Predisposition><Procedures><Progenitor Cell Transplantation><Prophylactic treatment><Prophylaxis><Recovery><Research><Resistance><Risk><Risk Estimate><Risk Factors><Risk Reduction><Role><SIS cytokines><Site><Stem Cell Transplantation><Stem cell transplant><Susceptibility><Techniques><Therapeutic><Therapeutic Fungicides><Time><Tissue Growth><Torulopsis glabrata><Transplant Recipients><Transplantation><White Blood Cells><White Cell><accurate diagnosis><anti-fungal><anti-fungal agents><anti-fungal drug><anti-fungal drug resistance><anti-fungal drug resistant><anti-fungal resistance><anti-fungal resistant><bio-markers><biologic marker><biomarker><blood stem cell transplantation><candidaemia><candidemia><chemoattractant cytokine><chemokine><cytokine><design><designing><early detection><enroll><first responder><functional restoration><fungal infection><fungus><fungus drug resistance><fungus infection><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><high risk><host response><human imaging><imaging><immune system response><immunoresponse><improved><improved outcome><in vivo><in vivo monitoring><infection risk><injuries><injury to tissue><leukemia><malignancy><mortality><neoplasm/cancer><neutrophil><novel imaging technology><ontogeny><pathophysiology><patient stratification><post-transplant><post-transplantation><posttransplant><posttransplantation><progenitor transplantation><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resistance to anti-fungal><resistant><resistant to anti-fungal><restoration><restore function><restore functionality><restore lost function><risk-reducing><social role><stem and progenitor cell transplantations><stratified patient><tissue injury><tool><transplant><transplant patient><white blood cell><white blood corpuscle><yeast infection>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Michael K Mansour

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$817,016
FY 2026

Project Title

In vivo Monitoring of Neutrophil Function in Patients after Stem Cell Transplant

Grant Number:

5R01AI176658-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/13/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Hematopoietic stem cell transplant (HSCT), an essential procedure in the treatment of patients with hematological malignancies, also temporarily increases the risk for infections with invasive fungi. The recovery in the neutrophil number after HSCT is commonly regarded as a key metric for the restor...

Research Terms

<Acceleration><Address><Azoles><Biological Markers><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood leukocyte><C albicans><C auris><C. albicans><C. auris><C. glabrata><C.albicans><CSF3><CSF3 gene><Cancers><Candida><Candida albicans><Candida auris><Candida glabrata><Candidiasis><Candidosis><Cell Body><Cells><Chemotactic Cytokines><Communication><Diagnosis><Dysfunction><Early Diagnosis><Effectiveness><Engineering><Enrollment><Functional disorder><Fungal Drug Resistance><Fungus Diseases><Fungus drug resistant><Future><G-CSF><GCSF><Generalized Growth><Goals><Growth><HSC transplantation><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Homologous Chemotactic Cytokines><Hospital Admission><Hospitalization><Human><Hyphae><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Immune response><In Vitro><Individual><Infection><Injury><Intercrines><Knowledge><Label><Leukocytes><Leukocytes Reticuloendothelial System><Life><MGC45931><Malignant Hematologic Neoplasm><Malignant Neoplasms><Malignant Tumor><Marrow Neutrophil><Marrow leukocyte><Measurement><Measures><Microscopic><Modern Man><Molecular><Monilia><Moniliasis><Monitor><Morbidity><Mycoses><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Outcome><Patients><Performance><Phagocytosis><Physiopathology><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Predisposition><Procedures><Progenitor Cell Transplantation><Prophylactic treatment><Prophylaxis><Recovery><Research><Resistance><Risk><Risk Estimate><Risk Factors><Risk Reduction><Role><SIS cytokines><Site><Stem Cell Transplantation><Stem cell transplant><Susceptibility><Techniques><Therapeutic><Therapeutic Fungicides><Time><Tissue Growth><Torulopsis glabrata><Transplant Recipients><Transplantation><White Blood Cells><White Cell><accurate diagnosis><anti-fungal><anti-fungal agents><anti-fungal drug><anti-fungal drug resistance><anti-fungal drug resistant><anti-fungal resistance><anti-fungal resistant><bio-markers><biologic marker><biomarker><blood stem cell transplantation><candidaemia><candidemia><chemoattractant cytokine><chemokine><cytokine><design><designing><early detection><enroll><first responder><functional restoration><fungal infection><fungus><fungus drug resistance><fungus infection><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><high risk><host response><human imaging><imaging><immune system response><immunoresponse><improved><improved outcome><in vivo><in vivo monitoring><infection risk><injuries><injury to tissue><leukemia><malignancy><mortality><neoplasm/cancer><neutrophil><novel imaging technology><ontogeny><pathophysiology><patient stratification><post-transplant><post-transplantation><posttransplant><posttransplantation><progenitor transplantation><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resistance to anti-fungal><resistant><resistant to anti-fungal><restoration><restore function><restore functionality><restore lost function><risk-reducing><social role><stem and progenitor cell transplantations><stratified patient><tissue injury><tool><transplant><transplant patient><white blood cell><white blood corpuscle><yeast infection>
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Meelad Dawlaty

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$775,399
FY 2026

Project Title

Dissecting the canonical and non-canonical functions of Tet2 in hematopoietic stem cells and hematologic disorders

Grant Number:

5R01HL148852-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2019

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Myelodysplastic syndrome (MDS) is a clonal hematological disorder. Patients exhibit either marked reductions in blood production, at times precipitating into bone marrow failure, significant dysplasia in the cells produced, or some combination of both. MDS is generally incurable by existing...

Research Terms

<Age><Alleles><Allelomorphs><Autoregulation><Binding><Biological Function><Biological Process><Biology><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone marrow failure><Causality><Cell Body><Cells><Cellular Assay><Chromatin><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Complex><DNA><DNA Methylation><DNA mutation><DNMT3a><Data><Deacetylation><Defect><Deoxyribonucleic Acid><Deposit><Deposition><Development><Dioxygenases><Disease><Disorder><Dysfunction><Dysmyelopoietic Syndromes><Dysplasia><ES cell><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equilibrium><Etiology><Exhibits><Family><Functional disorder><Gene Action Regulation><Gene Activation><Gene Down-Regulation><Gene Expression><Gene Expression Regulation><Gene Modified><Gene Regulation><Gene Regulation Process><Genes><Genetic Change><Genetic defect><Genetic mutation><Genomics><HDAC><HDAC Proteins><HSC regeneration><HSC self-renewal><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematology><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterozygote><Histone Deacetylase><Homeostasis><Human><Hydroxylation><Hypermethylation><In Vitro><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Link><Lymphoid><Lymphopoiesis><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Methylation><Mice><Mice Mammals><Microscope><Modeling><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Mutant Strains Mice><Mutate><Mutation><Myelodysplastic Disease><Myelodysplastic Syndromes><Myelogenous><Myeloid><Myelopoiesis><Null Mouse><Pathogenesis><Patients><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Production><Proteins><Publications><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Regulation><Role><Scientific Publication><Shapes><Smoldering Leukemia><Stress><Testing><Therapeutic><Time><Transcription Repression><Transfection><Transferase><Transferase Gene><Transgenes><Transplantation><ages><balance><balance function><base><bases><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell regeneration><blood stem cell self-renewal><blood-forming stem cell><causation><cell assay><chromatin modifier><comparative><daughter cell><defined contribution><demethylation><design><designing><developmental><differential expression><differentially expressed><disease causation><dyscrasia><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><epigenetically><epigenome><epigenomics><gene modification><gene repression><genetically modified><genome mutation><hDNA methyltransferase 3a><hematopoietic gene><hematopoietic progenitor><hematopoietic progenitor cell fate><hematopoietic progenitor cell self-renewal><hematopoietic stem and progenitor cell fate><hematopoietic stem cell fate><hematopoietic stem cell regeneration><hematopoietic stem cell self-renewal><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><heterozygosity><in vivo><innovate><innovation><innovative><insight><lymphocytopoiesis><member><mouse mutant><mutant><myelodysplasia><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><old age><oxidation><pathophysiology><prevent><preventing><progenitor biology><progenitor cell biology><progenitor cell gene><progenitor cell homeostasis><progenitor gene><programs><promoter><promotor><recruit><regeneration of blood stem cells><self - renewal in hematopoietic stem cells><self-renew><self-renewal><social role><stem and progenitor biology><stem cell biology><stem cell genes><stem cell homeostasis><stem cell of embryonic origin><transcriptional differences><transcriptomics><transgene><transplant><younger age>
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Keisuke Ito

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$775,399
FY 2026

Project Title

Dissecting the canonical and non-canonical functions of Tet2 in hematopoietic stem cells and hematologic disorders

Grant Number:

5R01HL148852-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2019

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Myelodysplastic syndrome (MDS) is a clonal hematological disorder. Patients exhibit either marked reductions in blood production, at times precipitating into bone marrow failure, significant dysplasia in the cells produced, or some combination of both. MDS is generally incurable by existing...

Research Terms

<Age><Alleles><Allelomorphs><Autoregulation><Binding><Biological Function><Biological Process><Biology><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone marrow failure><Causality><Cell Body><Cells><Cellular Assay><Chromatin><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Complex><DNA><DNA Methylation><DNA mutation><DNMT3a><Data><Deacetylation><Defect><Deoxyribonucleic Acid><Deposit><Deposition><Development><Dioxygenases><Disease><Disorder><Dysfunction><Dysmyelopoietic Syndromes><Dysplasia><ES cell><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equilibrium><Etiology><Exhibits><Family><Functional disorder><Gene Action Regulation><Gene Activation><Gene Down-Regulation><Gene Expression><Gene Expression Regulation><Gene Modified><Gene Regulation><Gene Regulation Process><Genes><Genetic Change><Genetic defect><Genetic mutation><Genomics><HDAC><HDAC Proteins><HSC regeneration><HSC self-renewal><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematology><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterozygote><Histone Deacetylase><Homeostasis><Human><Hydroxylation><Hypermethylation><In Vitro><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Link><Lymphoid><Lymphopoiesis><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Methylation><Mice><Mice Mammals><Microscope><Modeling><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Mutant Strains Mice><Mutate><Mutation><Myelodysplastic Disease><Myelodysplastic Syndromes><Myelogenous><Myeloid><Myelopoiesis><Null Mouse><Pathogenesis><Patients><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Production><Proteins><Publications><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Regulation><Role><Scientific Publication><Shapes><Smoldering Leukemia><Stress><Testing><Therapeutic><Time><Transcription Repression><Transfection><Transferase><Transferase Gene><Transgenes><Transplantation><ages><balance><balance function><base><bases><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell regeneration><blood stem cell self-renewal><blood-forming stem cell><causation><cell assay><chromatin modifier><comparative><daughter cell><defined contribution><demethylation><design><designing><developmental><differential expression><differentially expressed><disease causation><dyscrasia><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><epigenetically><epigenome><epigenomics><gene modification><gene repression><genetically modified><genome mutation><hDNA methyltransferase 3a><hematopoietic gene><hematopoietic progenitor><hematopoietic progenitor cell fate><hematopoietic progenitor cell self-renewal><hematopoietic stem and progenitor cell fate><hematopoietic stem cell fate><hematopoietic stem cell regeneration><hematopoietic stem cell self-renewal><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><heterozygosity><in vivo><innovate><innovation><innovative><insight><lymphocytopoiesis><member><mouse mutant><mutant><myelodysplasia><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><old age><oxidation><pathophysiology><prevent><preventing><progenitor biology><progenitor cell biology><progenitor cell gene><progenitor cell homeostasis><progenitor gene><programs><promoter><promotor><recruit><regeneration of blood stem cells><self - renewal in hematopoietic stem cells><self-renew><self-renewal><social role><stem and progenitor biology><stem cell biology><stem cell genes><stem cell homeostasis><stem cell of embryonic origin><transcriptional differences><transcriptomics><transgene><transplant><younger age>
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Rebekah L. Gundry

UNIVERSITY OF NEBRASKA MEDICAL CENTER, OMAHA, NE

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$752,150
FY 2026

Project Title

Harnessing Glycoproteomics and Glycomics to Understand Cardiac Biology and Disease

Grant Number:

5R35HL155460-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2021

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Our research program develops and applies innovative mass spectrometry technologies, bioinformatics tools, and methodologies to transform our understanding of cell surface proteins and glycans and answer outstanding questions in stem cell biology and cardiac pathology. Our analytical platfo...

Research Terms

<Biology><Body Tissues><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac Toxicity><Cardiocyte><Cardiotoxic><Cardiotoxicity><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Surface Glycoproteins><Cell Surface Proteins><Cell surface><Cells><Data><Development><Disease><Disorder><Drugs><Future><Genetic><Glycans><Heart><Heart Muscle Cells><Heart failure><Heart myocyte><Human><Intracellular Communication and Signaling><Ligand Binding><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Medication><Membrane><Membrane Glycoproteins><Methodology><Methods><Modern Man><Monitor><Outcome Study><Pathology><Patient Care><Patient Care Delivery><Patients><Pharmaceutical Preparations><Pluripotent Stem Cells><Polysaccharides><Progenitor Cells><Proteome><Reagent><Receptor Protein><Reproducibility><Research><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Speed><Surface Glycoproteins><System><Technology><Therapeutic><Tissues><bio-informatics tool><bioinformatics tool><biological signal transduction><biomarker array><biomarker panel><cardiac failure><cardiomyocyte><care for patients><care of patients><caring for patients><cell type><clinical applicability><clinical application><developmental><disease model><disorder model><drug detection><drug testing><drug/agent><experience><glycoproteomics><improved><innovate><innovation><innovative><marker panel><membrane structure><molecular phenotype><new marker><next generation><novel biomarker><novel marker><participatory sensing><pluripotent progenitor><progenitor biology><progenitor cell biology><programs><receptor><remote sensing><stem and progenitor biology><stem cell biology><stem cells><tech development><technology development><translational study>
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MICHAEL Bonaguidi

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$738,890
FY 2026

Project Title

Neural stem cell rejuvenation through single cell pharmacogenomics

Grant Number:

5R01AG076956-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Age is the major risk factor for most chronic human diseases, including Alzheimer’s disease (AD). Neural stem cells (NSCs) are particularly vulnerable to cellular aging and undergo functional decay in the mature brain. As a result, adult neurogenesis and its contributions to memory ...

Research Terms

<AD dementia><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Animals><Brain><Brain Nervous System><Cell Aging><Cell Body><Cell Reprogramming><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Chronic><Cognition><Country><Data><Encephalon><Goals><Government Agencies><Health><Institution><Legal><Mediating><Memory><Molecular><Monitor><Names><Neural Stem Cell><Pharmacogenomics><Primary Senile Degenerative Dementia><Procedures><Regenerative Medicine><Regenerative capacity><Rejuvenation><Replicative Senescence><Research><Research Resources><Resources><Risk Factors><Security><Societies><Systems Biology><Techniques><Work><adult neurogenesis><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age related alterations><age related changes><age specific alterations><age specific changes><aged hippocampus><aged mice><aged mouse><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging hippocampus><aging induced alterations><aging induced changes><aging prevention><aging preventive intervention><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><anti aging><anti geronic><anti-aging intervention><antiaging><behavior study><behavioral study><cellular reprogramming><changes with age><cognitive reserve><elderly mice><gene network><human disease><improved><insight><interventions targeting aging><name><named><naming><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new approaches><novel approaches><novel strategies><novel strategy><old mice><performance site><prevent age related><prevent aging><primary degenerative dementia><progenitor aging><progenitor and neural stem cells><progenitor cell aging><progenitor cell fate><progenitor cell function><progenitor cell pool><progenitor cell population><progenitor cell proliferation><progenitor fate><progenitor function><progenitor pool><progenitor population><progenitor proliferation><programs><regeneration ability><regeneration capacity><replicative aging><resilience><resilient><senile dementia of the Alzheimer type><stem and progenitor cell fate><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor cell proliferation><stem and progenitor function><stem cell aging><stem cell fate><stem cell function><stem cell pool><stem cell population><stem cell proliferation><suppress aging><transcriptomics>
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YOU-YANG ZHAO

LURIE CHILDREN'S HOSPITAL OF CHICAGO, CHICAGO, IL

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$721,176
FY 2026

Project Title

Novel intrinsic endothelial stem cells responsible for lung endothelial regeneration and vascular repair in ARDS

Grant Number:

5R01HL172447-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/22/2023

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Acute respiratory distress syndrome (ARDS) is a complex, multi-factorial syndrome with an unacceptable high mortality rate. Endothelial injury characterized by persistently increased lung microvascular permeability resulting in protein-rich lung edema is a hallmark of ARDS. In both animal models of ...

Research Terms

<21+ years old><ALI caused by sepsis><APC receptor><APLN><APLN gene><ARDS><Accounting><Acute><Acute Lung Injury><Acute Pulmonary Injury><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Adult><Adult ARDS><Adult Human><Adult RDS><Adult Respiratory Distress Syndrome><Animal Model><Animal Models and Related Studies><BUdR><Bilateral><Blood Vessels><BrdU><Bromodeoxyuridine><Bromouracil Deoxyriboside><Broxuridine><CLP model><CLP mouse model><Cecal ligation perforation><Cell Body><Cell Cycle Progression><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cells><Cellular Proliferation><Complex><Corynebacterium Diphtheriae Toxin><DTR Protein><Da Nang Lung><Data><Death Rate><Diphtheria Toxin><Diphtheria Toxin Sensitivity><Disease><Disorder><Dropsy><EPCR><EPCR gene><Edema><Endothelial Cells><Endothelial protein C receptor><Endothelium><FKHL16><FOXM1><FOXM1 gene><FOXM1B><Forkhead Box M1><Forkhead Box M1B Transcription Factor><Forkhead, Drosophila, Homolog-Like 16><Genes><Genetic><Genetic Induction><HB-EGF precursor><HFH11><Heart failure><Hydrops><Impairment><Infiltration><Inflammatory><Inflammatory Infiltrate><Injury><Label><Left><Lipopolysaccharides><Liquid substance><Lung><Lung Inflammation><Lung Respiratory System><Lung damage><Mediating><Mice><Mice Mammals><Microvascular Permeability><Modeling><Molecular><Murine><Mus><Names><Natural regeneration><Pathologic><Patients><Phase><Play><Pneumonitis><Prevention><Progenitor Cells><Proliferating><Proteins><Pulmonary Edema><Pulmonary Inflammation><Recovery><Regeneration><Reporter><Resolution><Role><Sepsis><Sepsis and ARDS><Shock Lung><Specific qualifier value><Specified><Stiff lung><Survival Rate><Syndrome><System><TRIDENT gene><TRIDENT protein><Time><Vascular Endothelium><Vascular Permeabilities><activated protein C receptor><acute hypoxemic respiratory failure><acute hypoxic respiratory failure><acute onset hypoxemic respiratory failure><acute respiratory distress syndrome caused by sepsis><adulthood><after sepsis><after septic><apelin><cardiac failure><cecal ligation and perforation><cecal ligation and puncture><cecal ligation puncture><cecum ligation and puncture><cecum ligation puncture><death due to sepsis><death related to sepsis><diphtheria toxin receptor><diptheria toxin receptor><effective therapy><effective treatment><endothelial cell protein C receptor><endothelial progenitor><endothelial progenitor cell><endothelial regeneration><endothelial stem cell><fluid><following sepsis><following septic><injuries><injury to the vasculature><liquid><lung edema><lung injury><lung microvascular endothelial cells><lung vascular cells><lung vascular endothelial cells><model of animal><mortality associated with sepsis><mortality in sepsis><mortality rate><name><named><naming><nano particle><nano-sized particle><nanoparticle><nanosized particle><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><plasmid DNA><polymicrobial sepsis><post sepsis><post septic><prevent><preventing><progenitor cell expansion><progenitor cell gene><progenitor cell proliferation><progenitor expansion><progenitor gene><progenitor proliferation><promoter><promotor><pulmonary><pulmonary arterial endothelial cell><pulmonary artery endothelial cell><pulmonary damage><pulmonary injury><pulmonary microvascular endothelial cells><pulmonary tissue damage><pulmonary tissue injury><pulmonary vascular cells><pulmonary vascular endothelial cells><regenerate><regenerative><repair><repaired><resolutions><scRNA sequencing><scRNA-seq><sepsis ARDS><sepsis acute respiratory distress syndrome><sepsis and acute respiratory distress syndrome><sepsis associated ALI><sepsis associated acute lung injury><sepsis associated acute respiratory distress syndrome><sepsis associated death><sepsis associated mortality><sepsis caused acute lung injury><sepsis caused deaths><sepsis death><sepsis induced ALI><sepsis induced ARDS><sepsis induced acute lung injury><sepsis induced acute respiratory distress syndrome><sepsis induced death><sepsis induced mortality><sepsis lethality><sepsis mediated ALI><sepsis mediated acute lung injury><sepsis mortality><sepsis related acute lung injury><sepsis related acute respiratory distress syndrome><sepsis related deaths><sepsis related mortality><septic death><septic mortality><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell expansion><stem and progenitor cell proliferation><stem cell depletion><stem cell exhaustion><stem cell expansion><stem cell fatigue><stem cell genes><stem cell proliferation><stem cells><vascular><vascular injury><wet lung>
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William Raymond Lagor

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$697,794
FY 2026

Project Title

Physiological Dissection of the Mevalonate Pathway

Grant Number:

5R01DK124477-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/6/2020

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The mevalonate pathway is responsible for the de novo synthesis of cholesterol and other biologically important isoprenoids from acetyl-CoA. Rates of cholesterol synthesis vary greatly amongst different cell types in the body. The long term goal of this project is to better understan...

Research Terms

<Ablation><Abscission><Acetyl CoA><Acetyl Coenzyme A><Acute><Adherent Culture><Automobile Driving><Bioavailability><Biological><Biological Availability><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Compartmentation><Cell Compartmentations><Cell Count><Cell Growth in Number><Cell Multiplication><Cell Number><Cell Proliferation><Cells><Cellular Membrane><Cellular Proliferation><Cholesterol><Cholesterol Synthesis Inhibition><Chylomicrons><Circulation><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><CoA><Coenzyme A><Data><Dehydrogenases><Devices><Dissection><Drugs><Enterocytes><Enzyme Gene><Enzymes><Epithelial Cells><Epithelium><Equilibrium><Excision><Excretory function><Extirpation><Feces><GC1><GEM model><GEMM model><GI Stem cell><GW112><Genetic><Genetically Engineered Mouse><Goals><HG38><Human><In Vitro><Individual><Intestinal><Intestines><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><LDL Receptors><LDLR gene><LGR5><LGR5 gene><Lipoprotein LDL Receptors><Lipoproteins><Liver><Low Density Lipoprotein Receptor><Mammalia><Mammals><Mediating><Medication><Mice><Mice Mammals><Modern Man><Monolayer culture><Murine><Mus><Null Mouse><OLFM4><OLFM4 gene><Olfactomedin 4><Organoids><Oxidoreductase><Oxidoreductase Gene><Pathway interactions><Pharmaceutical Preparations><Physiologic><Physiologic Availability><Physiological><Process><Progenitor Cells><Proteins><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Reductases><Regulation><Removal><Route><S-acetate Coenzyme A><SRE-2 binding protein><SREBP-2><Staining method><Stains><Sterols><Surface><Surgical Removal><Testing><Tissues><Upregulation><Villus><balance><balance function><biologic><bowel><cell type><cholesterol absorption><cholesterol biosynthesis><cholesterol control><cholesterol management><cholesterol trafficking><driving><drug/agent><excretion><experiment><experimental research><experimental study><experiments><gastrointestinal stem cell><genetically engineered mouse model><genetically engineered murine model><gut progenitor><gut stem cell><hepatic body system><hepatic organ system><improved><in vivo><insight><intestinal epithelium><intestinal progenitor><intestinal stem cells><isoprenoid><knock-down><knockdown><lipoprotein cholesterol><manage cholesterol><mevalonate><migration><overexpress><overexpression><pathway><preservation><progenitor cell expansion><progenitor cell homeostasis><progenitor cell niche><progenitor cell proliferation><progenitor cell regeneration><progenitor cell self renewal><progenitor expansion><progenitor niche><progenitor proliferation><progenitor regeneration><progenitor self renewal><programs><radiolabel><radiolabels><radiotracer><receptor><resection><stem and progenitor cell expansion><stem and progenitor cell niche><stem and progenitor cell proliferation><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell expansion><stem cell homeostasis><stem cell niche><stem cell proliferation><stem cell regeneration><stem cell self renewal><stem cells><sterol-regulatory element-binding protein 2><stool><transcriptome sequencing><transcriptomic sequencing><uptake>
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NOAH Freeman SHROYER

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$697,794
FY 2026

Project Title

Physiological Dissection of the Mevalonate Pathway

Grant Number:

5R01DK124477-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/6/2020

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The mevalonate pathway is responsible for the de novo synthesis of cholesterol and other biologically important isoprenoids from acetyl-CoA. Rates of cholesterol synthesis vary greatly amongst different cell types in the body. The long term goal of this project is to better understan...

Research Terms

<Ablation><Abscission><Acetyl CoA><Acetyl Coenzyme A><Acute><Adherent Culture><Automobile Driving><Bioavailability><Biological><Biological Availability><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Compartmentation><Cell Compartmentations><Cell Count><Cell Growth in Number><Cell Multiplication><Cell Number><Cell Proliferation><Cells><Cellular Membrane><Cellular Proliferation><Cholesterol><Cholesterol Synthesis Inhibition><Chylomicrons><Circulation><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><CoA><Coenzyme A><Data><Dehydrogenases><Devices><Dissection><Drugs><Enterocytes><Enzyme Gene><Enzymes><Epithelial Cells><Epithelium><Equilibrium><Excision><Excretory function><Extirpation><Feces><GC1><GEM model><GEMM model><GI Stem cell><GW112><Genetic><Genetically Engineered Mouse><Goals><HG38><Human><In Vitro><Individual><Intestinal><Intestines><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><LDL Receptors><LDLR gene><LGR5><LGR5 gene><Lipoprotein LDL Receptors><Lipoproteins><Liver><Low Density Lipoprotein Receptor><Mammalia><Mammals><Mediating><Medication><Mice><Mice Mammals><Modern Man><Monolayer culture><Murine><Mus><Null Mouse><OLFM4><OLFM4 gene><Olfactomedin 4><Organoids><Oxidoreductase><Oxidoreductase Gene><Pathway interactions><Pharmaceutical Preparations><Physiologic><Physiologic Availability><Physiological><Process><Progenitor Cells><Proteins><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Reductases><Regulation><Removal><Route><S-acetate Coenzyme A><SRE-2 binding protein><SREBP-2><Staining method><Stains><Sterols><Surface><Surgical Removal><Testing><Tissues><Upregulation><Villus><balance><balance function><biologic><bowel><cell type><cholesterol absorption><cholesterol biosynthesis><cholesterol control><cholesterol management><cholesterol trafficking><driving><drug/agent><excretion><experiment><experimental research><experimental study><experiments><gastrointestinal stem cell><genetically engineered mouse model><genetically engineered murine model><gut progenitor><gut stem cell><hepatic body system><hepatic organ system><improved><in vivo><insight><intestinal epithelium><intestinal progenitor><intestinal stem cells><isoprenoid><knock-down><knockdown><lipoprotein cholesterol><manage cholesterol><mevalonate><migration><overexpress><overexpression><pathway><preservation><progenitor cell expansion><progenitor cell homeostasis><progenitor cell niche><progenitor cell proliferation><progenitor cell regeneration><progenitor cell self renewal><progenitor expansion><progenitor niche><progenitor proliferation><progenitor regeneration><progenitor self renewal><programs><radiolabel><radiolabels><radiotracer><receptor><resection><stem and progenitor cell expansion><stem and progenitor cell niche><stem and progenitor cell proliferation><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell expansion><stem cell homeostasis><stem cell niche><stem cell proliferation><stem cell regeneration><stem cell self renewal><stem cells><sterol-regulatory element-binding protein 2><stool><transcriptome sequencing><transcriptomic sequencing><uptake>
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Jill A Helms

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$690,333
FY 2026

Project Title

Molecular mechanisms mediating the soft tissue attachment to teeth

Grant Number:

5R01DE031270-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/20/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project abstract Maintaining the junctional epithelium (JE) is of primary importance if preservation of the cementum, periodontal ligament (PDL), and alveolar bone is to be achieved. New insights into JE barrier functions came with our discovery of a Wnt- responsive stem cell niche in the JE. In thi...

Research Terms

<7S Gamma Globulin><Abscission><Address><Adenoviridae><Adenoviruses><Alveolodental Ligament><Alveolodental Membrane><Anatomic Sites><Anatomic structures><Anatomy><Autoregulation><BUdR><Beta Cadherin-Associated Protein><Beta-1 Catenin><Biochemical><Body Tissues><Bone Morphogenetic Protein Gene><Bone Morphogenetic Proteins><BrdU><Bromodeoxyuridine><Bromouracil Deoxyriboside><Broxuridine><Buccal Cavity><Buccal Cavity Head and Neck><CUL-2><Cavitas Oris><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Cycle Kinetics><Cell Differentiation><Cell Differentiation process><Cell Division Cycle><Cell Kinetics><Cell Signaling><Cells><Cementum><Chronic Periodontitis><Clinical><Connective Tissue><Data><Dental Cementum><Differentation Markers><Differentiation Antigens><Differentiation Markers><Disease><Disorder><Embryo><Embryonic><Epithelial Attachment><Epithelial Cell Junction><Epithelial Cell Proliferation><Epithelial Cells><Epithelium><Excision><Exposure to><Expression Signature><Extirpation><FISH Technic><FISH Technique><FISH analysis><FISH assay><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Formulation><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profile><Gene Expression Profiling><Genes><Gingiva><Gingival><Gingivectomy><Goals><Gum Disease><Harvest><Health><Hemidesmosomes><Heterogeneity><Histology><Homeostasis><Human><IgG><Immunoglobulin G><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Infiltration><Inflammatory><Injury><Intracellular Communication and Signaling><Investigators><Jaw><Junctional Epithelium><Knowledge><Label><Libraries><Ligature><Lineage Tracing><Maintenance><Marker Antigens><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Mouth><Murine><Mus><Natural regeneration><Operative Procedures><Operative Surgical Procedures><Oral><Oral cavity><PRO2286><Parodontosis><Pathway interactions><Periodontal Diseases><Periodontal Ligament><Periodontal Membrane><Periodontitis><Physiological Homeostasis><Placebos><Population><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Progenitor Cells><Proliferating><RNA Gene Probes><RNA Probes><Recombinants><Regeneration><Regenerative capacity><Removal><Reporter><Research Personnel><Researchers><Role><Series><Sham Treatment><Signal Transduction><Signal Transduction Systems><Signaling><Site><Skeleton><Sorting><Source><Staining method><Stains><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Tamoxifen><Testing><Therapeutic><Tissues><Tooth><Tooth structure><Tracer><Transcript Expression Analyses><Transcript Expression Analysis><WNT Signaling Pathway><WNT signaling><Wnt proteins><Wnt-3A protein><Work><Wound Repair><alveolar bone><alveolar supporting bone><analyze gene expression><beta cat><beta catenin><biological signal transduction><bone morphogenic protein><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular differentiation><cellular lineage mapping><cellular lineage tracking><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><epithelium regeneration><experiment><experimental research><experimental study><experiments><flow cytophotometry><gene expression analysis><gene expression assay><gene expression pattern><gene expression signature><inhibitor><injuries><injury and repair><innovate><innovation><innovative><insight><lipid based nanoparticle><lipid nanoparticle><maxilla alveolar process><native protein drug><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><notch><notch protein><notch receptors><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><pathway><periodontal disorder><periodontium disease><periodontium disorder><pharmaceutical protein><preservation><progenitor cell markers><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor cell regeneration><progenitor cell self renewal><progenitor markers><progenitor niche><progenitor pool><progenitor population><progenitor regeneration><progenitor self renewal><progenitor stem cell markers><protein distribution><protein drug agent><protein-based drug><regenerate><regenerate epithelium><regeneration ability><regeneration capacity><repair model><resection><restoration><self-renew><self-renewal><sham therapy><skeletons><social role><socket wall><soft tissue><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell biomarkers><stem cell markers><stem cell niche><stem cell pool><stem cell population><stem cell regeneration><stem cell self renewal><stem cells><surgery><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><teeth><therapeutic protein><tooth surface><transcriptional profile><transcriptional profiling><transcriptional signature><wound healing><wound recovery><wound resolution><β-catenin>
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Tien Peng

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$671,343
FY 2026

Project Title

Suppression of alveolar stem cells by tissue-resident lymphocytes in emphysema

Grant Number:

5R01HL177013-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Acute exacerbations in chronic obstructive lung disease (COPD) are often triggered by respiratory viral infections that leads to irreversible decline in lung function. Mechanistic insight into the pathophysiologic link between viral triggers and loss of lung structural cells...

Research Terms

<21+ years old><3-D><3-Dimensional><3D><Aberrant Tissue><Acute><Adult><Adult Human><Air><Alleles><Allelomorphs><Alveolar><Alveoli progenitor><Alveoli stem cell><Alveolus><Assay><Attenuated><Bioassay><Biological Assay><Blood Coagulation Factor III><Body Tissues><Bronchial Alveolus><Bronchioalveolar Lavage><Bronchoalveolar Lavage><Bronchopulmonary Lavage><CD142 Antigens><COPD><Cell Body><Cells><Chimera Protein><Chimeric Proteins><Choristoma><Chronic Bronchitis><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Chronic lung disease><Clinical><Coagulation Factor III><Coagulin><Data><Disease><Disorder><Drug Therapy><Dysfunction><Ectopic Tissue><Emphysema><Epithelium><Erinaceidae><Factor III><Fibroblasts><Functional disorder><Fusion Protein><GWA study><GWAS><Gases><Gene Expression><Genes><Genetic><Genetic Models><Glomerular Procoagulant Activity><Hedgehogs><Heterotopic Tissue><Host Factor><Host Factor Protein><Human><IFN><IFN activation><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><Immune><Immune Interferon><Immunes><Infiltration><Inflammation><Inflammatory><Inflammatory Response><Integration Host Factors><Interferon Activation><Interferon Gamma><Interferon Type II><Interferons><Label><Link><Liquid substance><Lung><Lung Alveolar Epithelia><Lung Inflammation><Lung Lavage><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lymphatic cell><Lymphocyte><Lymphocytic><Maps><Mediating><Mice><Mice Mammals><Modality><Modeling><Modern Man><Morbidity><Murine><Mus><Organoids><Pathway interactions><Patients><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiopathology><Pneumonitis><Predisposition><Predisposition gene><Progenitor Cells><Proteins><Prothrombinase><Publishing><Pulmonary Emphysema><Pulmonary Inflammation><Reagent><Recombinants><Residencies><Resolution><Role><Shortness of Breath><Stromal Cells><Structure of parenchyma of lung><Surface><Susceptibility><Susceptibility Gene><T-Cells><T-Lymphocyte><Testing><Therapeutic><Therapeutic Agents><Thromboplastin><Tissue Factor><Tissue Factor Procoagulant><Tissue Thromboplastin><Tissue imaging><Tissues><Tobacco><Tobacco smoke><Urothromboplastin><Viral><Viral Diseases><Viral Respiratory Tract Infection><Virus Diseases><adulthood><airway epithelium inflammation><airway inflammation><alveolar destruction><alveolar epithelium><alveolar progenitor><alveolar stem cell><attenuate><attenuates><bronchiolar alveolar lavage><bronchopulmonary lavage therapy><chronic obstructive pulmonary disorder><chronic pulmonary disease><cytokine><drug discovery><drug intervention><drug treatment><emphysematous><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><first responder><fluid><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><human model><in vivo><insight><lFN-Gamma><liquid><lung function><lung preservation><lung progenitor><lung stem cell><lung tissue stem cell><lung-specific stem cell><lymph cell><model of human><mortality><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><paracrine><pathogen><pathophysiology><pathway><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pre-clinical study><preclinical study><predisposing gene><progenitor cells in the lung><progenitors in the lung><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><pulmonary function><pulmonary progenitor><pulmonary stem cell><resolutions><respiratory inflammation><respiratory tract inflammation><respiratory virus><response><scale up><screening><screenings><self-renew><self-renewal><single cell analysis><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial relationship><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stem cells><stem cells in the lung><susceptibility allele><susceptibility locus><susceptibility variant><three dimensional><thymus derived lymphocyte><tool><transcriptomics><viral infection><viral respiratory infection><virus infection><virus-induced disease><whole genome association analysis><whole genome association study>
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Laura Lee Walkup

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$670,134
FY 2026

Project Title

Early detection of pulmonary complications of hematopoietic stem-cell transplantation in children using hyperpolarized xenon MRI

Grant Number:

5R01HL166335-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Late-onset, non-infectious pulmonary complications following hematopoietic stem-cell transplant (HSCT) occur in up to half of all patients, are heterogeneous in etiology and in clinical course, and are deadly. Spirometry is the cornerstone of surveillance, yet half of the pe...

Research Terms

<0-11 years old><18 year old><18 years of age><2 year old><2 years of age><3-D Imaging><3D imaging><5 year old><5 years of age><6 year old><6 years of age><Age><Awareness><Black Box><Blood Vessels><Blood erythrocyte><Body Tissues><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><Causality><Cell Communication and Signaling><Cell Signaling><Cessation of life><Characteristics><Child><Child Youth><Childhood><Childhood Injury><Children (0-21)><Clinical><Clinical Management><Computed Tomography><Contrast Agent><Contrast Drugs><Contrast Media><Data><Death><Defect><Diagnosis><Diagnostic><Diffusion><Disease><Disorder><Dysfunction><Early Diagnosis><Early Intervention><Ensure><Erythrocytes><Erythrocytic><Etiology><Evaluation><Functional disorder><Gases><Goals><HSC transplantation><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Heterogeneity><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><Individual><Inhalation><Inhaling><Intracellular Communication and Signaling><Lung><Lung Diseases><Lung Function Tests><Lung Grafting><Lung Respiratory System><Lung Transplantation><Lung damage><MR Imaging><MR Tomography><MRI><MRI Scans><MRIs><Magnetic Resonance Imaging><Magnetic Resonance Imaging Scan><Malignant><Malignant - descriptor><Marrow erythrocyte><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Monitor><Morbidity><NMR Imaging><NMR Tomography><Neonatal><Non-Malignant><Nuclear Magnetic Resonance Imaging><Nursery Schools><Obstruction><Outcome><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phenotype><Physiologic><Physiological><Physiopathology><Population><Process><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Graft><Pulmonary Transplant><Pulmonary Transplantation><Pulmonary function tests><Radiopaque Media><Red Blood Cells><Red Cell><Research><Resolution><Risk><Sampling><Scanning><School-Age Population><Sedation procedure><Signal Transduction><Signal Transduction Systems><Signaling><Source><Spirometry><Techniques><Testing><Therapeutic><Three-Dimensional Imaging><Tissues><Toddler><Tomodensitometry><Translating><Transplant Recipients><Work><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xe element><Xenon><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><Zeugmatography><age 18><age 18 years><age 2><age 2 years><age 5><age 5 years><age 6><age 6 years><aged 2 years><aged two years><ages><biological signal transduction><blood corpuscles><blood stem cell transplantation><catscan><causation><chest CT><chest computed tomography><choking agent><clinical applicability><clinical application><clinical care><clinical risk><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><diagnostic approach><diagnostic strategy><diffused><diffuses><diffusing><diffusions><disease causation><disease of the lung><disorder of the lung><early detection><eighteen year old><eighteen years of age><experience><five year old><five years of age><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><image-based method><imaging><imaging method><imaging modality><improved><improved outcome><individualized management><individualized patient management><individualized therapeutic><injured child><injured children><injury in children><innovate><innovation><innovative><interstitial><kids><lung disorder><lung function><lung function decline><lung injury><lung transplant><microvascular pathology><mortality><neonate><non-contrast CT><noncontrast CT><noncontrast computed tomography><nonmalignant><novel><pathophysiology><patient oriented outcomes><pediatric><pediatric injury><personalized clinical management><personalized disease management><personalized management><personalized therapeutic><pre-k><pre-kindergarten><precision management><preschool><pulmonary><pulmonary agents><pulmonary damage><pulmonary function><pulmonary function decline><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><resolutions><response to therapy><response to treatment><risk stratification><school age><sedation><six year old><six years of age><stratify risk><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic response><therapy response><transplant patient><treatment response><treatment responsiveness><two year old><two years of age><vascular><vascular abnormality><vascular component><vascular factor><ventilation><volunteer><youngster>
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NOAH Freeman SHROYER

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$637,298
FY 2026

Project Title

Mechanisms of telomere-induced disease: Role of intestinal malabsorption, barrier dysfunction and dsybiosis.

Grant Number:

5R01DK127037-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Although it is increasingly recognized that the interaction of the diet and host specific genetic factors in the gut play an important role in intestinal and systemic disease, our understanding of in this emerging field is still limited and this represents an important knowledge gap. Here we propose...

Research Terms

<Acceleration><Address><Age><Antioncogene Protein p53><Apoptosis><Apoptosis Pathway><Atrophic><Atrophy><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Biology><Biopsy><Body Tissues><CaCo2><Caco-2 Cells><Cancers><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Line><Cell Lineage><CellLine><Cells><Cellular Tumor Antigen P53><Colitis><Consumption><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><DNA Damage><DNA Injury><DNA mutation><Defect><Development><Diet><Disease><Disorder><Dysfunction><Enterocytes><Enzyme Gene><Enzymes><Epithelium><Exposure to><Fructokinases><Fructose><Functional disorder><GI Stem cell><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Granulomatous Enteritis><HNF4><HNF4-Alpha><HNF4A><HNF4A gene><Hepatocyte Nuclear Factor 4-Alpha><Hepatocyte Nuclear Factor, 4><Human><Impairment><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal><Intestinal Diseases><Intestinal Disorder><Intestines><KO mice><Ketohexokinases><Knock-out Mice><Knockout Mice><Knowledge><Length><Levulose><Maintenance><Malabsorption Syndromes><Malignant Neoplasms><Malignant Tumor><Measures><Mediating><Metabolic stress><Mice><Mice Mammals><Microvilli><Microvillus><Mitochondria><Modern Man><Murine><Mus><Mutation><Null Mouse><Older Population><Oncoprotein p53><Organoids><P53><Pathogenesis><Pathogenicity><Pathology><Patients><Phenotype><Phosphoprotein P53><Phosphoprotein pp53><Physiopathology><Play><Predisposition><Prevention><Prognostic Marker><Programmed Cell Death><Protein TP53><Proteins><Proteomics><RNA Seq><RNA sequencing><RNAseq><Relapse><Repression><Research><Risk><Role><Scanning Electron Microscopy><Small Intestines><Source><Strains Cell Lines><Structure><Supplementation><Susceptibility><System><Systemic disease><TCF14><TP53><TP53 gene><TRP53><Telomerase><Telomere Shortening><Testing><Therapeutic><Time><Tissues><Toxic effect><Toxicities><Transcription Factor 14, Hepatic Nuclear Factor><Transcription Factor Proto-Oncogene><Transcription factor genes><Transmission Electron Microscopy><Tumor Protein p53><Tumor Protein p53 Gene><Ulcerated Colitis><Ulcerative Colitis><absorption><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><aged mice><aged mouse><ages><bowel><bowel inflammation><cellular differentiation><cellular microvillus><coping><cultured cell line><design><designing><developmental><diets><driving><elderly mice><eleocolitis><gastrointestinal absorption disorder><gastrointestinal stem cell><genome mutation><gut inflammation><gut progenitor><gut stem cell><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><intestinal autoinflammation><intestinal barrier><intestinal inflammation><intestinal malabsorption><intestinal mucosal barrier><intestinal progenitor><intestinal stem cells><intestine disease><intestine disorder><malabsorption><malignancy><methods to study multiple-level influences><mitochondrial><mitochondrial dysfunction><mortality><mouse model><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><murine model><natural aging><neoplasm/cancer><normal aging><normative aging><novel><old mice><older groups><older individuals><older person><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pathophysiology><patient population><preservation><prevent><preventing><progenitor cell regeneration><progenitor cell self renewal><progenitor regeneration><progenitor self renewal><prognostic biomarker><prognostic indicator><protein p53><regional enteritis><response><risk stratification><scrK protein><senescence><senescent><small bowel><social role><stem><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell depletion><stem cell exhaustion><stem cell fatigue><stem cell regeneration><stem cell self renewal><stratify risk><sugar><telomere><telomere attrition><therapeutic stratification><transcription factor><transcriptome sequencing><transcriptomic sequencing><treatment stratification>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ergun Sahin

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$637,298
FY 2026

Project Title

Mechanisms of telomere-induced disease: Role of intestinal malabsorption, barrier dysfunction and dsybiosis.

Grant Number:

5R01DK127037-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Although it is increasingly recognized that the interaction of the diet and host specific genetic factors in the gut play an important role in intestinal and systemic disease, our understanding of in this emerging field is still limited and this represents an important knowledge gap. Here we propose...

Research Terms

<Acceleration><Address><Age><Antioncogene Protein p53><Apoptosis><Apoptosis Pathway><Atrophic><Atrophy><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Biology><Biopsy><Body Tissues><CaCo2><Caco-2 Cells><Cancers><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Line><Cell Lineage><CellLine><Cells><Cellular Tumor Antigen P53><Colitis><Consumption><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><DNA Damage><DNA Injury><DNA mutation><Defect><Development><Diet><Disease><Disorder><Dysfunction><Enterocytes><Enzyme Gene><Enzymes><Epithelium><Exposure to><Fructokinases><Fructose><Functional disorder><GI Stem cell><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Granulomatous Enteritis><HNF4><HNF4-Alpha><HNF4A><HNF4A gene><Hepatocyte Nuclear Factor 4-Alpha><Hepatocyte Nuclear Factor, 4><Human><Impairment><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal><Intestinal Diseases><Intestinal Disorder><Intestines><KO mice><Ketohexokinases><Knock-out Mice><Knockout Mice><Knowledge><Length><Levulose><Maintenance><Malabsorption Syndromes><Malignant Neoplasms><Malignant Tumor><Measures><Mediating><Metabolic stress><Mice><Mice Mammals><Microvilli><Microvillus><Mitochondria><Modern Man><Murine><Mus><Mutation><Null Mouse><Older Population><Oncoprotein p53><Organoids><P53><Pathogenesis><Pathogenicity><Pathology><Patients><Phenotype><Phosphoprotein P53><Phosphoprotein pp53><Physiopathology><Play><Predisposition><Prevention><Prognostic Marker><Programmed Cell Death><Protein TP53><Proteins><Proteomics><RNA Seq><RNA sequencing><RNAseq><Relapse><Repression><Research><Risk><Role><Scanning Electron Microscopy><Small Intestines><Source><Strains Cell Lines><Structure><Supplementation><Susceptibility><System><Systemic disease><TCF14><TP53><TP53 gene><TRP53><Telomerase><Telomere Shortening><Testing><Therapeutic><Time><Tissues><Toxic effect><Toxicities><Transcription Factor 14, Hepatic Nuclear Factor><Transcription Factor Proto-Oncogene><Transcription factor genes><Transmission Electron Microscopy><Tumor Protein p53><Tumor Protein p53 Gene><Ulcerated Colitis><Ulcerative Colitis><absorption><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><aged mice><aged mouse><ages><bowel><bowel inflammation><cellular differentiation><cellular microvillus><coping><cultured cell line><design><designing><developmental><diets><driving><elderly mice><eleocolitis><gastrointestinal absorption disorder><gastrointestinal stem cell><genome mutation><gut inflammation><gut progenitor><gut stem cell><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><intestinal autoinflammation><intestinal barrier><intestinal inflammation><intestinal malabsorption><intestinal mucosal barrier><intestinal progenitor><intestinal stem cells><intestine disease><intestine disorder><malabsorption><malignancy><methods to study multiple-level influences><mitochondrial><mitochondrial dysfunction><mortality><mouse model><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><murine model><natural aging><neoplasm/cancer><normal aging><normative aging><novel><old mice><older groups><older individuals><older person><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pathophysiology><patient population><preservation><prevent><preventing><progenitor cell regeneration><progenitor cell self renewal><progenitor regeneration><progenitor self renewal><prognostic biomarker><prognostic indicator><protein p53><regional enteritis><response><risk stratification><scrK protein><senescence><senescent><small bowel><social role><stem><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell depletion><stem cell exhaustion><stem cell fatigue><stem cell regeneration><stem cell self renewal><stratify risk><sugar><telomere><telomere attrition><therapeutic stratification><transcription factor><transcriptome sequencing><transcriptomic sequencing><treatment stratification>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JIAN FENG

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$618,417
FY 2026

Project Title

Epigenetics-Based Autism Treatment with Animal Models and Human Stem Cells

Grant Number:

5R01NS127728-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Summary This project aims to discover novel pharmacological intervention for core symptoms of autism, including social deficits and repetitive behaviors. One of the causal factors of autism is the loss of Shank3 gene, which encodes a scaffolding protein at glutamatergic synapses. We will use Shank3-...

Research Terms

<22q13 deletion syndrome><AOF2><ASD><ASD patient><Address><Animal Model><Animal Models and Related Studies><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Autopsy><Basal Transcription Factor><Basal transcription factor genes><Behavioral><Biochemical><Body Tissues><Causality><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Chromosomal, Gene, or Protein Abnormality><Corpus Striatum><Corpus striatum structure><Cytogenetic or Molecular Genetic Abnormality><DNA mutation><Defect><Drug Therapy><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Exhibits><Exons><Fibroblasts><Functional disorder><Gene Activation><Gene Down-Regulation><Gene Expression><Gene Expression Alteration><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Abnormality><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genetic study><Genomics><Glutamates><Goals><Heterozygote><Histones><Human><Human Genetics><Impairment><Induced pluripotent stem cell derived neurons><Infantile Autism><KDM1A><KDM1A gene><Kanner's Syndrome><L-Glutamate><L-Lysine><LSD1><Large-Scale Sequencing><Length><Link><Lysine><Lysine-Specific Demethylase 1><Lysine-Specific Demethylase 1A><Mediating><Methylation><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Abnormality><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neuronal Differentiation><Neurons><Neurophysiology / Electrophysiology><Pathogenicity><Patients><Pharmacological Treatment><Pharmacotherapy><Phelan-McDermid syndrome><Phenotype><Physiopathology><Play><Prefrontal Cortex><Proteins><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Research><Risk Factors><Risk-associated variant><Role><Scaffolding Protein><Social Interaction><Striate Body><Striatum><Synapses><Synaptic><Testing><Therapeutic><Therapeutic Effect><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription Repression><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Translating><Work><autism attributes><autism indicator><autism model><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic><autistic features><autistic patient><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><causation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><demethylation><disease causation><drug discovery><drug intervention><drug treatment><electrophysiological><epigenetically><gene repression><genome mutation><genome scale><genome-wide><genomewide><glutamatergic><heterozygosity><hiPSC><high risk><histone H3 methyltransferase><histone demethylase><histone methylase><histone methylation><histone methyltransferase><histone modification><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human progenitor><human progenitor cell derived><human stem cell-derived><human stem cells><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><innovate><innovation><innovative><interdisciplinary approach><knock-down><knockdown><loss of function mutation><model of animal><model of autism spectrum disorder><molecular aberrations><mouse model><multidisciplinary approach><murine model><necropsy><neurodevelopmental disease><neuronal><neuronal excitability><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathophysiology><patient with ASD><permissiveness><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><postmortem><progenitor cell differentiation><progenitor differentiation><repetitive behavior><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><side effect><social defects><social deficits><social disorders><social dysfunction><social role><stem and progenitor differentiation><stem cell approach><stem cell based approach><stem cell differentiation><stem cell method><stem cell methodology><stem cell procedure><stem cell technique><stem cell technology><striatal><synapse><synapse function><synaptic function><targeted agent><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcription factor><transcriptome sequencing><transcriptomic sequencing><treatment strategy>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Zhen Yan

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$618,417
FY 2026

Project Title

Epigenetics-Based Autism Treatment with Animal Models and Human Stem Cells

Grant Number:

5R01NS127728-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Summary This project aims to discover novel pharmacological intervention for core symptoms of autism, including social deficits and repetitive behaviors. One of the causal factors of autism is the loss of Shank3 gene, which encodes a scaffolding protein at glutamatergic synapses. We will use Shank3-...

Research Terms

<22q13 deletion syndrome><AOF2><ASD><ASD patient><Address><Animal Model><Animal Models and Related Studies><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Autopsy><Basal Transcription Factor><Basal transcription factor genes><Behavioral><Biochemical><Body Tissues><Causality><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Chromosomal, Gene, or Protein Abnormality><Corpus Striatum><Corpus striatum structure><Cytogenetic or Molecular Genetic Abnormality><DNA mutation><Defect><Drug Therapy><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Exhibits><Exons><Fibroblasts><Functional disorder><Gene Activation><Gene Down-Regulation><Gene Expression><Gene Expression Alteration><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Abnormality><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genetic study><Genomics><Glutamates><Goals><Heterozygote><Histones><Human><Human Genetics><Impairment><Induced pluripotent stem cell derived neurons><Infantile Autism><KDM1A><KDM1A gene><Kanner's Syndrome><L-Glutamate><L-Lysine><LSD1><Large-Scale Sequencing><Length><Link><Lysine><Lysine-Specific Demethylase 1><Lysine-Specific Demethylase 1A><Mediating><Methylation><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Abnormality><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neuronal Differentiation><Neurons><Neurophysiology / Electrophysiology><Pathogenicity><Patients><Pharmacological Treatment><Pharmacotherapy><Phelan-McDermid syndrome><Phenotype><Physiopathology><Play><Prefrontal Cortex><Proteins><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Research><Risk Factors><Risk-associated variant><Role><Scaffolding Protein><Social Interaction><Striate Body><Striatum><Synapses><Synaptic><Testing><Therapeutic><Therapeutic Effect><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription Repression><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Translating><Work><autism attributes><autism indicator><autism model><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic><autistic features><autistic patient><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><causation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><demethylation><disease causation><drug discovery><drug intervention><drug treatment><electrophysiological><epigenetically><gene repression><genome mutation><genome scale><genome-wide><genomewide><glutamatergic><heterozygosity><hiPSC><high risk><histone H3 methyltransferase><histone demethylase><histone methylase><histone methylation><histone methyltransferase><histone modification><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human progenitor><human progenitor cell derived><human stem cell-derived><human stem cells><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><innovate><innovation><innovative><interdisciplinary approach><knock-down><knockdown><loss of function mutation><model of animal><model of autism spectrum disorder><molecular aberrations><mouse model><multidisciplinary approach><murine model><necropsy><neurodevelopmental disease><neuronal><neuronal excitability><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathophysiology><patient with ASD><permissiveness><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><postmortem><progenitor cell differentiation><progenitor differentiation><repetitive behavior><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><side effect><social defects><social deficits><social disorders><social dysfunction><social role><stem and progenitor differentiation><stem cell approach><stem cell based approach><stem cell differentiation><stem cell method><stem cell methodology><stem cell procedure><stem cell technique><stem cell technology><striatal><synapse><synapse function><synaptic function><targeted agent><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcription factor><transcriptome sequencing><transcriptomic sequencing><treatment strategy>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kalpaj Rajnikant Parekh

UNIVERSITY OF IOWA, IOWA CITY, IA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$616,024
FY 2026

Project Title

Pathogenesis of Airway Stem Cell Abnormalities in Obliterative Bronchiolitis

Grant Number:

5R01HL136370-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2019

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Lung transplantation has become the standard of care for end-stage lung diseases with no available medical therapy. However, long-term survival after lung transplantation is affected by development of chronic lung allograft dysfunction (CLAD), which is progressively fatal and for whi...

Research Terms

<14-3-3 Sigma><Abnormal Cell><Address><Affect><Air><Allografting><Alveolar><Animal Model><Animal Models and Related Studies><Basal Cell><Basket Cell><Biopsy><Bronchiolitis><COPD><Cause of Death><Cell Body><Cells><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clone Cells><Coupled><Cystic Fibrosis><Development><Distal><Drug Screening><Dysfunction><Early Diagnosis><Epithelial Cells><Epithelium><Expression Signature><Ferrets><Fibrosing Alveolitis><Fibrosis><Functional disorder><Funding><Gene Expression Profile><Gland><Glandular Cell><Human><Impairment><In Vitro><Inflammatory><Inflammatory Response><Investigation><Investigators><Keratin><Knowledge><Label><Link><Liquid substance><Lung><Lung Diseases><Lung Grafting><Lung Respiratory System><Lung Transplantation><Mediating><Medical><Mice><Mice Mammals><Modeling><Modern Man><Mucoviscidosis><Murine><Mus><Myoepithelial cell><Natural regeneration><Orthoptics><Outcome><Pathogenesis><Phenotype><Physiopathology><Pleoptic><Prevention><Progenitor Cells><Proliferating><Property><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Graft><Pulmonary Transplant><Pulmonary Transplantation><Regeneration><Regenerative response><Regulation><Research><Research Personnel><Researchers><Respiratory Epithelium><Rodent Model><Role><SFN gene><Staining method><Stains><Stratifin><Structure of respiratory epithelium><Submucosa><Surface><Tamoxifen><Testing><Therapeutic><Time><Transplantation><airway epithelial stem cells><airway epithelium><airway injury><airway progenitor><airway repair><airway stem cells><basal progenitor><basal stem cell><biomarker identification><chronic obstructive pulmonary disorder><developmental><diffuse interstitial pulmonary fibrosis><disease of the lung><disorder of the lung><early detection><effective therapy><effective treatment><end stage disease><epithelium regeneration><fibrogenesis><fluid><gene expression pattern><gene expression signature><human model><identification of biomarkers><identification of new biomarkers><idiopathic pulmonary fibrosis><impaired airway><in vivo><injured airway><injury response><knock-down><knockdown><liquid><lung allograft><lung disorder><lung transplant><marker identification><model of animal><model of human><multipotency><multipotent><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><pathophysiology><prevent><preventing><progenitor cell fate><progenitor cell function><progenitor cell niche><progenitor fate><progenitor function><progenitor niche><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><public health relevance><regenerate><regenerate epithelium><regeneration response><repair><repaired><respiratory injury><respiratory progenitor><respiratory stem cell><respiratory tract epithelium><respiratory tract injury><response to injury><social role><standard of care><stem and progenitor cell fate><stem and progenitor cell function><stem and progenitor cell niche><stem and progenitor function><stem cell depletion><stem cell exhaustion><stem cell fate><stem cell fatigue><stem cell function><stem cell niche><stem cells><stem cells in the airway><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><transcriptional profile><transcriptional signature><transplant><transplant model>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Wa Xian

UNIVERSITY OF IOWA, IOWA CITY, IA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$616,024
FY 2026

Project Title

Pathogenesis of Airway Stem Cell Abnormalities in Obliterative Bronchiolitis

Grant Number:

5R01HL136370-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2019

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Lung transplantation has become the standard of care for end-stage lung diseases with no available medical therapy. However, long-term survival after lung transplantation is affected by development of chronic lung allograft dysfunction (CLAD), which is progressively fatal and for whi...

Research Terms

<14-3-3 Sigma><Abnormal Cell><Address><Affect><Air><Allografting><Alveolar><Animal Model><Animal Models and Related Studies><Basal Cell><Basket Cell><Biopsy><Bronchiolitis><COPD><Cause of Death><Cell Body><Cells><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clone Cells><Coupled><Cystic Fibrosis><Development><Distal><Drug Screening><Dysfunction><Early Diagnosis><Epithelial Cells><Epithelium><Expression Signature><Ferrets><Fibrosing Alveolitis><Fibrosis><Functional disorder><Funding><Gene Expression Profile><Gland><Glandular Cell><Human><Impairment><In Vitro><Inflammatory><Inflammatory Response><Investigation><Investigators><Keratin><Knowledge><Label><Link><Liquid substance><Lung><Lung Diseases><Lung Grafting><Lung Respiratory System><Lung Transplantation><Mediating><Medical><Mice><Mice Mammals><Modeling><Modern Man><Mucoviscidosis><Murine><Mus><Myoepithelial cell><Natural regeneration><Orthoptics><Outcome><Pathogenesis><Phenotype><Physiopathology><Pleoptic><Prevention><Progenitor Cells><Proliferating><Property><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Graft><Pulmonary Transplant><Pulmonary Transplantation><Regeneration><Regenerative response><Regulation><Research><Research Personnel><Researchers><Respiratory Epithelium><Rodent Model><Role><SFN gene><Staining method><Stains><Stratifin><Structure of respiratory epithelium><Submucosa><Surface><Tamoxifen><Testing><Therapeutic><Time><Transplantation><airway epithelial stem cells><airway epithelium><airway injury><airway progenitor><airway repair><airway stem cells><basal progenitor><basal stem cell><biomarker identification><chronic obstructive pulmonary disorder><developmental><diffuse interstitial pulmonary fibrosis><disease of the lung><disorder of the lung><early detection><effective therapy><effective treatment><end stage disease><epithelium regeneration><fibrogenesis><fluid><gene expression pattern><gene expression signature><human model><identification of biomarkers><identification of new biomarkers><idiopathic pulmonary fibrosis><impaired airway><in vivo><injured airway><injury response><knock-down><knockdown><liquid><lung allograft><lung disorder><lung transplant><marker identification><model of animal><model of human><multipotency><multipotent><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><pathophysiology><prevent><preventing><progenitor cell fate><progenitor cell function><progenitor cell niche><progenitor fate><progenitor function><progenitor niche><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><public health relevance><regenerate><regenerate epithelium><regeneration response><repair><repaired><respiratory injury><respiratory progenitor><respiratory stem cell><respiratory tract epithelium><respiratory tract injury><response to injury><social role><standard of care><stem and progenitor cell fate><stem and progenitor cell function><stem and progenitor cell niche><stem and progenitor function><stem cell depletion><stem cell exhaustion><stem cell fate><stem cell fatigue><stem cell function><stem cell niche><stem cells><stem cells in the airway><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><transcriptional profile><transcriptional signature><transplant><transplant model>
View Full Project Details on NIH Reporter
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James R Roede

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$611,887
FY 2026

Project Title

Altered Hippocampal Neurogenesis and Cognition via Maneb-mediated Changes in the Thiol Redox Proteome.

Grant Number:

4R01ES027593-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2017

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

The overall goal of this proposal is to elucidate the thiol redox mechanisms that alter neurodevelopment, which can exacerbate cognitive dysfunction in Down syndrome (DS). Down syndrome (DS) is the most common genetic cause of intellectual disability. Importantly, the extent of intellectual disabili...

Research Terms

<Abnormal Cell><Active Follow-up><Active Oxygen><Affect><Ammon Horn><Arsenic><Awareness><Beta Cadherin-Associated Protein><Beta-1 Catenin><Biological><Biological Function><Biological Process><CUL-2><Cadmium><Carbon><Cd element><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chemicals><Chromosome 21><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Cytosol><D-Glucose><Data><Decision Making><Degenerative Neurologic Disorders><Development><Developmental Toxicant><Dextrose><Disturbance in cognition><Down Syndrome><Dysfunction><Electrophysiology><Electrophysiology (science)><Embryo Development><Embryogenesis><Embryonic Development><Environment><Environmental Factor><Environmental Risk Factor><Environmental Toxin><Event><Exhibits><Exposure to><Fluorescence><Foundations><Functional disorder><Funding><Gene Expression><Gene x Environment Interaction><Genetic><Genetic Diseases><Gestation><Glucose><Glycolysis><Goals><GxE interaction><Hippocampus><Immunoblotting><Impaired cognition><Individual><Individuals with down syndrome><Induced pluripotent stem cell derived neurons><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intermediary Metabolism><Intracellular Communication and Signaling><Investigation><Isotope Labeling><Knowledge><Laboratories><Langdon Down syndrome><Libraries><Link><Live Birth><Maneb><Mediating><Mercaptans><Mercapto Compounds><Metabolic><Metabolic Processes><Metabolic dysfunction><Metabolism><Metals><Mitochondria><Mongolism><NPC><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural Development><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neurons><Neurophysiology / Electrophysiology><Normal Cell><Nuclear Pore Complex><Outcome><Output><Oxidation-Reduction><Oxidative Stress><Oxygen Radicals><PRO2286><Parents><Pathway interactions><Physiopathology><Poison><Pregnancy><Pro-Oxidants><Process><Progenitor Cells><Proteome><Proteomics><Publishing><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><Reactive Oxygen Species><Redox><Regulation><Reporting><Research><Risk><Role><Scheme><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Special Population><Stress><Subcellular Process><Sulfhydryl Compounds><System><Testing><Thiols><Time><Toxic Chemical><Toxic Environmental Agents><Toxic Environmental Substances><Toxic Substance><Toxic effect><Toxicant exposure><Toxicities><Trisomy 21><United States><Validation><WNT Signaling Pathway><WNT signaling><Western Blotting><Western Immunoblotting><Xenobiotics><abnormal protein homeostasis><abnormal proteostasis><active followup><arsenics><beta cat><beta catenin><biologic><biological signal transduction><cellular differentiation><chromosome 21 trisomy><chromosome 21 trisomy syndrome><cognitive dysfunction><cognitive function><cognitive loss><congenital acromicria syndrome><defective proteostasis><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><differentiation of pluripotent stem cells><differentiation protocol><directed differentiation><down syndrome individuals><down syndrome patients><electrophysiological><environment effect on gene><environmental chemical><environmental risk><environmental toxicant><extracellular><follow up><follow-up><followed up><followup><fungicidal><fungicide><gene environment interaction><genetic condition><genetic disorder><hippocampal><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><improved outcome><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><intellectual and developmental disability><limited intellectual functioning><metabolism measurement><metabolomics><metabonomics><mitochondrial><morbus Down><neurodegenerative illness><neurodevelopment><neurogenesis><neuronal><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><neurotoxic><novel><oxidation><oxidation reduction reaction><parent><pathophysiology><pathway><patient population><patients with down syndrome><people with down syndrome><pluripotent stem cell differentiation><preference><progenitor cell fate><progenitor cell maintenance><progenitor fate><progenitor maintenance><protein blotting><protein homeostasis><protein homeostasis decline><protein homeostasis deficiency><protein homeostasis dysfunction><protein homeostasis failure><protein homeostasis loss><proteostasis><proteostasis decline><proteostasis defect><proteostasis deficiency><proteostasis dysfunction><proteostasis dysregulation><proteostasis failure><proteostasis impairment><proteostasis loss><pseudohypertrophic progressive muscular dystrophy><qRTPCR><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell fate><stem cell fate><stem cell maintenance><stem cells><sulfhydryl group><tool><toxic compound><toxic exposure><toxicant><transcriptomics><trisomy 21 syndrome><validations><β-catenin>
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Laertis Ikonomou

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$603,620
FY 2026

Project Title

Gene regulatory networks in early lung epithelial cell fate decisions

Grant Number:

5R01HL158965-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT The long-term goal of this project is to develop stem-cell-based, autologous therapies for diseases affecting the lung epithelium. Different potential approaches for the use of stem cells for lung disease treatment include enhancement of endogenous stem cell differentiation ...

Research Terms

<21+ years old><AAT deficiency><ARP1 protein><ATAC sequencing><ATAC-seq><ATACseq><Address><Adult><Adult Human><Affect><Air><Alveolar><Animal Model><Animal Models and Related Studies><Anterior><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Autologous><Basal Transcription Factor><Basal transcription factor genes><Beta Cadherin-Associated Protein><Beta-1 Catenin><Binding><Binding Sites><Bioassay><Biological Assay><Body Tissues><CAGH44><COPD><COUP transcription factor II><COUP-TF II><COUP-TFII><CRISPR activation><CRISPR activator><CRISPR based activation><CRISPR gene activation><CRISPR interference><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-dCAS9 Activator><CRISPR-dCas9-mediated repression><CRISPR-mediated transcriptional activation><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/dCas9 activation><CRISPR/dCas9 interference><CRISPR/dCas9-based transcriptional activation><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRa><CRISPRi><CUL-2><Cell Body><Cell Communication and Signaling><Cell Line><Cell Lineage><Cell Signaling><Cell Transplantation><CellLine><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats interference><Combining Site><Competence><Complex><Computer Models><Computerized Models><Computing Methodologies><Coupled><Cystic Fibrosis><DNA Binding><DNA Binding Interaction><DNA bound><Data><Dependence><Derivation><Derivation procedure><Development><Differentiation in cell culture><Disease><Disorder><Distal><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Embryonic Tissue><Endoderm><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelial Cells><Epithelium><Ethical Issues><FOXP2><FOXP2 gene><Fertilized Egg><Fertilized Ovum><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Fore-Brain><Forebrain><Foregut><Forkhead Box P2><GWA study><GWAS><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic><Genetic Models><Genetic Transcription><Goals><Heterogeneity><Homeo Domain><Human><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><In Vitro><In vitro cell differentiation><Intracellular Communication and Signaling><Knowledge><Lead><Link><Liquid substance><Lung><Lung Alveolar Epithelia><Lung Diseases><Lung Respiratory System><Maps><Mediator><Mice><Mice Mammals><Modeling><Modern Man><Molecular Interaction><Morphology><Mucoviscidosis><Murine><Mus><NR2F2><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Organism><PRO2286><Pathway interactions><Patients><Pattern><Pb element><Pluripotent Stem Cells><Population><Primitive foregut structure><Primordium><Process><Progenitor Cells><Prosencephalon><Pulmonary Body System><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Organ System><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Reactive Site><Regenerative Medicine><Regulation><Regulatory Regions><Reporter><Respiratory Epithelium><Respiratory System><Respiratory Tracts><Respiratory tract structure><Role><Signal Transduction><Signal Transduction Systems><Signaling><Sorting><Specific qualifier value><Specified><Strains Cell Lines><Structure of respiratory epithelium><System><TNRC10><Techniques><Testing><Thyroid><Thyroid Gland><Thyroid Head and Neck><Time><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transplantation><Trinucleotide Repeat-Containing Gene 10><WNT Signaling Pathway><WNT signaling><Work><a1-antitrypsin deficiency><activating CRISPR technology><adulthood><airway epithelium><alpha 1-Antitrypsin Deficiency><alpha-1-anti-trypsin deficiency><alpha1-antitrypsin deficiency><alveolar epithelium><apoAI regulatory protein-1><apolipoprotein AI regulatory protein 1><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><beta cat><beta catenin><biological signal transduction><cell type><cellular transplant><chicken ovalbumin upstream promoter-transcription factor II><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chronic obstructive pulmonary disorder><clinical applicability><clinical application><clinical relevance><clinically relevant><computational methodology><computational methods><computational modeling><computational models><computer based method><computer based models><computer methods><computerized modeling><computing method><cultured cell line><customized therapy><customized treatment><developmental><differentiation in culture><differentiation in vitro><differentiation protocol><directed differentiation><disease model><disease of the lung><disorder model><disorder of the lung><embryo tissue><endogenous progenitor><endogenous stem cells><epigenetically><epigenomics><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><flow cytophotometry><fluid><gain of function><gene function><gene manipulation><gene regulatory network><genetic manipulation><genetic regulatory element><genetically manipulate><genetically perturb><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><heavy metal Pb><heavy metal lead><homeodomain><human derived pluripotent stem cell><human pluripotent stem cell><iPS><iPSC><iPSC technology><iPSCs><immunocytochemistry><in vitro Model><in vitro cellular differentiation><in vivo><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell technology><inducible pluripotent cell><inducible pluripotent stem cell><insight><knock-down><knockdown><liquid><living system><loss of function><lung development><lung disorder><lung function><lung progenitor><lung stem cell><lung tissue stem cell><lung-specific stem cell><model of animal><mouse genetics><mouse model><multi-modality><multimodality><multipotency><multipotent><murine model><mutant><novel><nuclear receptor subfamily 2, group F, member 2><overexpress><overexpression><pathway><patient specific therapies><patient specific treatment><pluripotent progenitor><preimplantation><progenitor><progenitor cell based therapy><progenitor cell differentiation><progenitor cell therapy><progenitor cell treatment><progenitor cells in the lung><progenitor differentiation><progenitor therapy><progenitor treatment><progenitors in the lung><programs><pulmonary function><pulmonary progenitor><pulmonary stem cell><repressing CRISPR-dCas9 system><respiratory tract epithelium><scRNA sequencing><scRNA-seq><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spatial and temporal><spatial temporal><spatial temporal imaging><spatial temporal mapping><spatiotemporal><spatiotemporal imaging><spatiotemporal mapping><stem and progenitor cell therapy><stem and progenitor differentiation><stem cell based therapy><stem cell differentiation><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><stem cells in the lung><tailored medical treatment><tailored therapy><tailored treatment><tool><transcription factor><transcriptome sequencing><transcriptomic sequencing><transcriptomics><transplant><unique treatment><whole genome association analysis><whole genome association study><zygote><α-1 anti-trypsin deficiency><α-1-antitrypsin deficiency><α1-Antitrypsin Deficiency><β-catenin>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Justin Adam Colacino

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$601,223
FY 2026

Project Title

Developmental Exposures, Stem Cell Reprogramming, and Breast Cancer Disparities

Grant Number:

5R01ES028802-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2018

End Date:

10/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract. This application is to renew R01ES028802, Dr. Colacino’s Outstanding New Environmental Scientist (ONES) award. The goal of this project is to define the impacts of chemical exposures on breast cancer disparities. There are profound breast cancer disparities by race. African American women ...

Research Terms

<Access to Care><African American Females><African American Women><American><Award><Basal Cell><Biological Markers><Biology><Breast><Breast Cancer><Cancer Biology><Cancer Causing Agents><Cancers><Carcinogens><Caucasian Females><Caucasian Women><Causality><Cell Body><Cell Reprogramming><Cells><Characteristics><Chemical Exposure><Chemicals><Chromatin><Communities><Complex><Data><Data Set><Development><Diagnosis><Dichlorodiphenyl Dichloroethylene><Diet><Disparities><Disparity><Dose><Environment><Epidemiological data><Epidemiology><Epidemiology data><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelium><Etiology><European><Evaluation><Exercise><Exposure disparity><Exposure to><Expression Signature><Gene Expression Profile><Gene Transcription><Genes><Genetic><Genetic Transcription><Goals><Health Services Accessibility><Heavy Metals><Human><Hybrid Cells><Hybrids><Image><In Vitro><Individual><Lead><Link><Malignant Breast Neoplasm><Malignant Neoplasms><Malignant Tumor><Measures><Mesenchymal><Methods><Michigan><Modern Man><Molecular><Molecular Epidemiology><Molecular Fingerprinting><Molecular Profiling><Molecular Target><Multiple types of exposure><Oncogens><Outcome><PFAS><Parabens><Pathway interactions><Pb element><Pesticides><Phenotype><Poly-fluoroalkyl substances><Precision therapeutics><Preventative strategy><Prevention strategy><Preventive strategy><Progenitor Cells><RNA Expression><Reproductive Factors><Reproductive History><Reproductive History Epidemiology><Reproductive Issues><Research><Scientist><Somatic Cell Hybrids><Stem Cell like><TNBC><Testing><Toxic effect><Toxicities><Toxicology><Transcription><Update><Validation><White Females><White Women><Woman><access to health services><access to services><access to treatment><accessibility to health services><aggressive breast cancer><availability of services><bio-markers><biologic marker><biomarker><black female><black women><breast progenitor><breast progenitor cell><breast stem cell><cancer disparity><cancer health disparity><cancer-related health disparity><care access><causation><cellular reprogramming><chemical association><cohort><community engagement><community partners><community-based partners><death risk><developmental><diets><disease causation><disparate effect><disparate impact><disparate result><disparities in race><disparity due to race><disparity in cancer><disparity in health><engagement with communities><epidemiologic><epidemiologic data><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><exposed human population><functional outcomes><gene expression pattern><gene expression signature><health disparity><health service access><health services availability><heavy metal Pb><heavy metal lead><human exposure><imaging><individualized prevention><inequality due to race><inequitable effect><inequitable impact><inequitable outcome><inequity due to race><insight><malignancy><malignant breast tumor><mammary gland progenitor><mammary gland stem cells><mammary progenitor><mammary stem cells><molecular biomarker><molecular marker><molecular profile><molecular signature><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mortality><mortality risk><multi-exposure><multiple exposures><multitude of exposure><neoplasm/cancer><new approaches><novel approaches><novel strategies><novel strategy><oncogenic agent><outcome disparities><outcome inequality><outcome inequity><p,p'-DDE><p,p-Dichlorodiphenyldichloroethylene><pathway><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><personalized prevention><phthalates><polyfluorinated alkyl substances><polyfluoroalkyl substances><precision prevention><precision therapies><precision treatment><progenitor capacity><progenitor cell expansion><progenitor cell like><progenitor expansion><progenitor-like><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial disparity><racial inequality><racial inequity><racially unequal><service availability><social health determinants><stem and progenitor cell expansion><stem cell characteristics><stem cell expansion><stem cells><stem-like><stemness><toxicant><transcriptional profile><transcriptional signature><transcriptome profiling><transcriptomic profiling><transcriptomics><translational impact><treatment access><treatment strategy><triple-negative breast cancer><triple-negative invasive breast carcinoma><unequal effect><unequal impact><unequal outcome><validations><various exposures><various types of exposure>
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DANICA CHEN

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$589,967
FY 2026

Project Title

Neural Stem Cell Aging and Neurodegeneration

Grant Number:

5R01AG082105-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Perturbation of mitochondrial proteostasis, a form of mitochondrial stress, activates the mitochondrial unfolded protein response (UPRmt), a retrograde signaling pathway leading to transcriptional up-regulation of mitochondrial chaperones and stress relief. Recent advances in mitocho...

Research Terms

<AD dementia><AD patients><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease patient><Alzheimer's patient><Alzheimers Dementia><Amentia><Ammon Horn><Attenuated><Autoregulation><Biochemical><Bioenergetics><Biogenesis><Biology><Body Tissues><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Cell Body><Cell Death><Cells><Chaperone><Chromatin><Chronic Disease><Chronic Illness><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Data><Defect><Degenerative Disorder><Dementia><Dentate Fascia><Deterioration><Development><Disease><Disorder><Disturbance in cognition><Dysfunction><Fascia Dentata><Functional disorder><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Genomic approach><Growth><Gyrus Dentatus><Gyrus Hippocampi><Gyrus Parahippocampalis><HDAC4><HDAC4 gene><HDACA><Hippocampal Gyrus><Hippocampus><Histone Deacetylase 4><Histone Deacetylase A><Homeostasis><Impaired cognition><Increase lifespan><Intermediary Metabolism><Intervention><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><Link><Mammalia><Mammals><Metabolic Processes><Metabolism><Mitochondria><Mitochondrial Proteins><Molecular Chaperones><Nerve Degeneration><Neural Stem Cell><Neuron Degeneration><Null Mouse><Nutrient><Origin of Life><Oxidative Stress><Parahippocampal Gyrus><Pathway interactions><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Predisposition><Primary Senile Degenerative Dementia><Progenitor Cells><Proliferating><Proteins><RNA Expression><Repression><Risk Factors><Role><Signal Pathway><Stress><Susceptibility><Testing><Tissue Growth><Tissues><Transcription><Translations><Upregulation><aged mice><aged mouse><ages><aging associated disease><aging associated disorders><aging related disease><aging related disorders><attenuate><attenuates><boost longevity><chronic disorder><cognitive dysfunction><cognitive loss><degenerative condition><degenerative disease><dentate gyrus><developmental><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><drug development><elderly mice><elongating the lifespan><enhance healthspan><enhance longevity><experience><extend healthspan><extend life span><extend lifespan><extend longevity><extending healthy lifespan><feasibility testing><foster longevity><gain of function><genetic approach><genetic strategy><genomic effort><genomic strategy><healthspan><healthspan extension><healthy life span><hippocampal><improve healthspan><improve lifespan><improve longevity><improved><increase healthspan><knock-down><knockdown><life span><lifespan><lifespan extension><mitochondrial><model organism><mouse model><murine model><natural aging><necrocytosis><nerve stem cell><neural control><neural degeneration><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural regulation><neural stem and progenitor cells><neurodegeneration><neurodegenerative><neurogenesis><neurogenic progenitors><neurogenic stem cell><neurological degeneration><neuromodulation><neuromodulatory><neuron progenitors><neuronal degeneration><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><neuroregulation><normal aging><normative aging><novel><old age><old mice><ontogeny><overexpress><overexpression><oxidative damage><oxidative injury><pathophysiology><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><premature><prematurity><primary degenerative dementia><progenitor aging><progenitor and neural stem cells><progenitor cell aging><progenitor cell maintenance><progenitor maintenance><programs><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><prolong healthspan><prolong lifespan><prolong longevity><promote healthspan><promote lifespan><promote longevity><protein folding><protein homeostasis><proteostasis><response><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><sensor><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem cell aging><stem cell maintenance><stem cells><support longevity><tissue degeneration><translation>
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Sean P Palecek

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$578,478
FY 2026

Project Title

Technologies enabling robust closed-loop manufacturing of human pluripotent stem cell-derived cardiomyocytes

Grant Number:

5R01HL178095-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Cell therapy is a rapidly growing field, with Chimeric Antigen Receptor T (CART) cells and stem cell-based therapies showing remarkable efficacy in treating hematologic cancers and regenerating tissue for conditions like Parkinson’s Disease, blindness, type 1 diabetes, and heart fai...

Research Terms

<3-D><3-Dimensional><3D><ATAC sequencing><ATAC-seq><ATACseq><Address><Adoption><Assay for Transposase-Accessible Chromatin using sequencing><Benchmarking><Best Practice Analysis><Bioinformatics><Bioreactors><Biotech><Biotechnology><Blindness><Body Tissues><Brittle Diabetes Mellitus><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><Cell Therapy><CellLine><Cells><Chromatin><Clinical Treatment><Clinical Trials><Complex><Data><Data Set><Development><Disease><Disorder><Dose><Drug Screening><Early identification><Effectiveness><Engineering><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Extracellular Signal-Regulated Kinase Gene><Failure><Feedback><Fluorescence><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><Generations><Genetic><Genetic Transcription><Goals><Heart Diseases><Heart Muscle Cells><Heart Vascular><Heart failure><Heart myocyte><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Human Development><IDDM><In Vitro><Insulin-Dependent Diabetes Mellitus><Intracellular Communication and Signaling><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><MAP Kinase Gene><MAPK><Malignant Cell><Malignant Hematologic Neoplasm><Medicine><Mitogen-Activated Protein Kinase Gene><Modeling><Molecular><Molecular Fingerprinting><Molecular Profiling><Natural regeneration><Network Analysis><Outcome><Output><Paralysis Agitans><Parkinson><Parkinson Disease><Pathway Analysis><Pathway interactions><Physiology><Population><Pre-Clinical Model><Preclinical Models><Primary Parkinsonism><Process><Process Assessment><Production><Progenitor Cells><Protocol><Protocols documentation><RNA Expression><Regeneration><Reporting><Reproducibility><Running><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Stem cell in the heart><Strains Cell Lines><Sudden-Onset Diabetes Mellitus><T cells for CAR><T1 DM><T1 diabetes><T1D><T1DM><Technology><Testing><Therapeutic><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Transposase><Treatment Failure><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Variant><Variation><Vision Disorders><Visual Disorder><analyze gene expression><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><benchmark><biological signal transduction><bioprocess><cancer cell><cardiac failure><cardiac progenitor><cardiac stem cell><cardiomyocyte><cell based intervention><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chimeric antigen T cell receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><circulatory system><clinical applicability><clinical application><clinical intervention><clinical relevance><clinical therapy><clinically relevant><cost><cultured cell line><developmental><differentiation of pluripotent stem cells><differentiation protocol><disease model><disorder model><drug development><epigenetically><epigenomics><frontier><gene expression analysis><gene expression assay><gene regulatory network><heart disorder><heart progenitor><heart stem cell><human derived pluripotent stem cell><human pluripotent stem cell><improved><insulin dependent diabetes><insulin dependent type 1><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><manufacture><manufacturing process><microbioreactor><molecular profile><molecular signature><network models><pathway><pluripotent stem cell differentiation><progenitor cell based therapy><progenitor cell therapy><progenitor cell treatment><progenitor therapy><progenitor treatment><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><scRNA sequencing><scRNA-seq><sensor><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><small molecule><stem and progenitor cell therapy><stem cell based therapy><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><therapy failure><three dimensional><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptional profiling><transcriptomics><trial regimen><trial treatment><type I diabetes><type one diabetes><vision loss><visual loss>
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Mark B Van Doren

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$566,881
FY 2026

Project Title

Regulation of sex-specific development by transcription factors

Grant Number:

5R01HD119709-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2016

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Homologs of Drosophila Doublesex (Dsx), the Dsx, MAB-3 Related Transcription Factors (DMRTs), are known to control gonad sexual dimorphism across the animal kingdom, from planaria and water fleas, to worms, flies, mice and man. Patients with mutations in DMRT1 exhibit XY gonad dysgen...

Research Terms

<ATAC sequencing><ATAC-seq><ATACseq><Animals><Assay for Transposase-Accessible Chromatin using sequencing><Aves><Avian><Basal Transcription Factor><Basal transcription factor genes><Birds><Body Tissues><Cannot achieve a pregnancy><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chromatin><Cladocera><Cyst><DNA mutation><Data><Development><Developmental Process><Differences of sex development><Difficulty conceiving><Drosophila><Drosophila genus><Ecdysone><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Estrogens><Exhibits><Family><Female><Fertilization><Flies><Gametes><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><GeneHomolog><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Change><Genetic defect><Genetic mutation><Genomic approach><Genomics><Genotype><Germ Cells><Germ Lines><Germ-Line Cells><Gonadal Dysgenesis><Gonadal Steroid Hormones><Gonadal structure><Gonosomes><Health><Homolog><Homologous Gene><Homologue><Human><Infertility><Intracellular Communication and Signaling><Invertebrata><Invertebrates><Life><Ligands><Mammalia><Mammals><Mice><Mice Mammals><Modeling><Modern Man><Molting Hormone><Morphogenesis><Murine><Mus><Mutate><Mutation><Names><Nature><Organ><Organism><Ovary><Pathway interactions><Patients><Process><Progenitor Cells><Regulation><Repression><Reproductive Cells><Role><Sex Cell><Sex Chromosomes><Sex Hormones><Sex Steroid Hormones><Sexual Development><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Single-Nucleus Sequencing><Somatic Cell><Specific qualifier value><Specified><Stem Cell Development><Supporting Cell><System><Testicles><Testis><Testosterone><Therapeutic Estrogen><Therapeutic Steroid Hormone><Therapeutic Testosterone><Time><Tissues><Trans-Testosterone><Transcript Expression Analyses><Transcript Expression Analysis><Transcription Factor Proto-Oncogene><Transcription factor genes><Vertebrate Animals><Vertebrates><Water Flea><Work><adult progenitor><adult stem cell><analyze gene expression><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><biological signal transduction><cell type><comparing females and males><comparing women and men><daughter cell><developmental><disorder of sexual development><embryo cell><females compared to males><females compared with males><females versus males><females vs. males><fertility cessation><fertility loss><fertilizations><fly><fruit fly><gene expression analysis><gene expression assay><genome mutation><genomic effort><genomic strategy><germ stem cells><germline progenitor><germline progenitor cells><germline stem cells><gonad><gonad development><gonad formation><gonadal dysgenesis syndrome><gonadal steroids><gonads><hormonal signals><hormone signals><infertile><initial cell><interest><living system><loss of function><male><man><member><morphogenetic process><mutant><name><named><naming><pathway><prevent><preventing><progenitor cell development><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor development><progenitor niche><progenitor pool><progenitor population><recruit><response><sNuc-Seq><sertoli cell><sex><sex determination><sex development><sex development disorder><sex dimorphism><sex steroid><sexual cell><sexual dimorphism><sexually dimorphic><single cell next generation sequencing><single cell sequencing><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><somatic progenitor><somatic stem cell><stem and progenitor cell development><stem and progenitor cell niche><stem and progenitor cell population><stem cell niche><stem cell pool><stem cell population><stem cells><stem cells in the germline><steroid hormone><testis sustentacular cell><transcription factor><transcriptional profiling><vertebrata><women compared to men><women compared with men><women versus men><women vs. men><♀><♂>
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Alexander Revzin

MAYO CLINIC ROCHESTER, ROCHESTER, MN

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$555,713
FY 2026

Project Title

Engineering microcapsules for scalable differentiation of human pluripotent stem cells into hepatocytes

Grant Number:

5R01DK137231-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Millions of people worldwide are affected by liver diseases. Some of these individuals progress to acute or acute- on-chronic liver failure where liver transplant becomes the only recourse. Given the shortage of transplantable organs, over >40% of patients on the waitlist do not receive a l...

Research Terms

<21+ years old><Acute><Address><Adult><Adult Human><Affect><Artificial Liver><Benchmarking><Best Practice Analysis><Bioartificial Liver><Bioreactors><Body Tissues><Cadaver><Capsules><Cell Body><Cell Communication and Signaling><Cell Protection><Cell Signaling><Cell Transplantation><Cells><Chronic><Cues><Cytoprotection><DNA Molecular Biology><DNA Synthesis Factor><Data><Development><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Encapsulated><Endoderm><Endothelial Cell Growth Factor><Engineering><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><FGF><Family suidae><Fibroblast Growth Factor><Fibroblast Growth Factor Gene Family><Fibroblast Growth Regulatory Factor><Future><Goals><Grafting Procedure><Growth Agents><Growth Factor><Growth Substances><Heparin><Heparinic Acid><Hepatic><Hepatic Cells><Hepatic Disorder><Hepatic Failure><Hepatic Mass><Hepatic Parenchymal Cell><Hepatic Transplantation><Hepatocyte><Human><Hydrogels><Immunofluorescence><Immunofluorescence Immunologic><Individual><Intracellular Communication and Signaling><Kinetics><Liver><Liver Cells><Liver Failure><Liver Grafting><Liver Mass><Liver Transplant><Liver diseases><Maintenance><Mechanics><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Microcapsules drug delivery system><Modern Man><Molecular Biology><Monitor><Nodal><Non-Polyadenylated RNA><Nutrient><O element><O2 element><Organ><Organ Transplantation><Organ Transplants><Oxygen><Patients><Persons><Phenotype><Pigs><Progenitor Cells><Protein Biosynthesis><Proteins Growth Factors><RNA><RNA Gene Products><Reagent><Recovery><Ribonucleic Acid><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Risk><Signal Transduction><Signal Transduction Systems><Signaling><Source><Suidae><Suspension Culture><Swine><System><Therapeutic><Tissues><Transplantation><Waiting Lists><Zoonoses><Zoonotic><Zoonotic Infection><adulthood><aqueous><benchmark><biological signal transduction><blood glucose regulation><cadaveric><cadavers><capsule><cell type><cellular transplant><communicable disease transmission><cost><cytoprotective><density><design><designing><detoxification><developmental><differentiation of pluripotent stem cells><differentiation protocol><disease transmission><epigenetically><glucose control><glucose homeostasis><glucose regulation><hESC><hepatic body system><hepatic disease><hepatic organ system><hepatopathy><human ES cell><human ESC><human derived pluripotent stem cell><human disease><human embryonic stem cell><human pluripotent stem cell><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infectious disease transmission><interest><liver disorder><liver function><liver transplantation><mechanic><mechanical><microbioreactor><microcapsule><novel><organ allograft><organ graft><organ xenograft><pluripotency><pluripotent state><pluripotent stem cell differentiation><porcine><progenitor cell based therapy><progenitor cell differentiation><progenitor cell therapy><progenitor cell treatment><progenitor differentiation><progenitor therapy><progenitor treatment><protein synthesis><sensor><spheroids><stem and progenitor cell therapy><stem and progenitor differentiation><stem cell based therapy><stem cell differentiation><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><suid><tech development><technology development><timeline><transplant><waitlist>
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Yingzi Yang

HARVARD MEDICAL SCHOOL, BOSTON, MA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$547,435
FY 2026

Project Title

Cellular and molecular control of periodontal tissue regeneration

Grant Number:

5R01DE033991-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/16/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Periodontal diseases (PDs) are major causes of tooth loss and a significant public health burden in the world. Reconstruction of healthy periodontal tissue damaged by injury or diseases is a major goal of periodontal treatment. The periodontium supports and invests the tooth and is composed of alveo...

Research Terms

<21+ years old><Adult><Adult Human><Alveolodental Ligament><Alveolodental Membrane><Apical><Area><Autoregulation><Body Tissues><CD34><CD34 gene><CXCL12><CXCL12 gene><CXCL12 protein><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Signaling><Cells><Cementum><Cervical><Characteristics><Chemokine (C-X-C Motif) Ligand 12><Chemotactic Cytokines><Chronic Periodontitis><Connective Tissue><Defect><Dental><Dental Cementum><Disease><Disorder><Environment><Exposure to><Focal Infection><GLI Family Gene><GLI Family Protein><GLI Protein><GLI gene><GLI1><GLI1 Gene><GLI1 Protein><Genes><Genetic><Gingiva><Gingival><Glioma Associated Oncogene Homolog 1 Protein><Glioma Associated Oncogene Homolog Protein><Glioma-Associated Oncogene Homolog><Glioma-associated oncogene><Goals><Gum Disease><HPCA1><Homeostasis><Homologous Chemotactic Cytokines><Human><Inflammation><Inflammatory><Injury><Intercrines><Intracellular Communication and Signaling><Investigators><Investments><Knowledge><Ligands><Ligature><Lineage Tracing><Location><Maintenance><Mammalia><Mammals><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Modern Man><Molecular><Natural regeneration><Organism-Level Process><Organismal Process><PBSF><Paradentium><Parodontosis><Pathologic Processes><Pathological Processes><Periodontal Diseases><Periodontal Ligament><Periodontal Membrane><Periodontal Pocket><Periodontitis><Periodontium><Physiologic Processes><Physiological Homeostasis><Physiological Processes><Play><Pre-B Cell Growth Stimulating Factor><Predisposition><Prevention><Progenitor Cells><Property><Public Health><Publishing><Regeneration><Regulation><Research Personnel><Researchers><Role><SCYB12><SDF-1><SDF-1A><SDF-1B><SDF-1alpha><SDF1><SDF1A><SDF1B><SHH><SHH gene><SIS cytokines><Sdf1 protein><Shapes><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Sonic Hedgehog><Stromal Cell-Derived Factor 1><Susceptibility><Systemic infection><TLSF-A><TLSF-B><TPAR1><Testing><Tissues><Tooth><Tooth Apex><Tooth Loss><Tooth Supporting Structures><Tooth Tissue><Tooth structure><adulthood><alveolar bone><alveolar supporting bone><angiogenesis><biological signal transduction><bone><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><chemoattractant cytokine><chemokine><critical injury><devastating injury><experiment><experimental research><experimental study><experiments><glioma associated oncogene 1><glioma associated oncogene family zinc finger 1><hIRH><infection localized><inflammatory environment><inflammatory milieu><injuries><injury and repair><insight><local infection><maxilla alveolar process><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><mouse model><murine model><novel><oral bacteria><oral flora><periodontal disorder><periodontium disease><periodontium disorder><prevent><preventing><progenitor cell expansion><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor cell proliferation><progenitor expansion><progenitor niche><progenitor pool><progenitor population><progenitor proliferation><reconstruction><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><scRNA sequencing><scRNA-seq><severe injury><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><socket wall><stem and progenitor cell expansion><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor cell proliferation><stem cell expansion><stem cell niche><stem cell pool><stem cell population><stem cell proliferation><stem cells><stromal cell-derived factor-1alpha><teeth><tissue regeneration><tissue regrowth><tissue renewal><tissue repair><tissue specific regeneration>
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Xunlei Kang

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$486,426
FY 2026

Project Title

Explore niche-leukemic stem cell interactions and evaluate niche-directed leukemia treatments

Grant Number:

1R01CA300057-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Title: Explore niche-leukemic stem cell interactions and evaluate niche-directed leukemia treatments. Retention of minimal residual leukemic stem cells (LSCs) within the bone marrow (BM) microenvironment, known as the niche, plays a pivotal role in therapeutic resistance and leukemia...

Research Terms

<AMD-3100><AMD3100><Address><Area><Assay><Binding><Bioassay><Biological Assay><Biopsy><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Tissue><Bone marrow biopsy><Bone marrow-derived mesenchymal stem cells><CXCL12><CXCL12 gene><CXCL12 protein><Cancellous bone><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Locomotion><Cell Migration><Cell Movement><Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Migration><Cellular Motility><Chemokine (C-X-C Motif) Ligand 12><Chemoresistance><Complex><Control Groups><Data><Development><Dipeptidyl Aminopeptidases><Dipeptidyl Peptidases><Dipeptidylpeptide Hydrolases><Disease Progression><Disease remission><Environment><Evaluation><GPC3><GPC3 gene><Genomic approach><Glypican 3><Goals><Human><Intracellular Communication and Signaling><Investigation><Knock-out><Knockout><Leukemic progenitor and stem cell><Malignant Cell><Marrow><Measurable><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Interaction><Murine><Mus><N-Cadherin><PBSF><PDX model><Pathogenesis><Patient derived xenograft><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Play><Plerixafor><Pre-B Cell Growth Stimulating Factor><Progenitor Cells><Property><Rat Homolog of OCI-5><Regulation><Relapse><Remission><Remission Induction Therapy><Research><Residual><Residual Cancers><Residual state><Role><SCYB12><SDF-1><SDF-1A><SDF-1B><SDF-1alpha><SDF1><SDF1A><SDF1B><Sdf1 protein><Shapes><Shelter facility><Signal Transduction><Signal Transduction Systems><Signaling><Source><Stem Cell like><Stromal Cell-Derived Factor 1><TLSF-A><TLSF-B><TPAR1><Testing><Transplantation><Treatment Efficacy><biological signal transduction><bone marrow mesenchymal progenitor><bone marrow mesenchymal stem cell><cancer cell><cancer microenvironment><cell behavior><cell motility><cellular behavior><chemoresistant><chemotherapy><chemotherapy resistance><chemotherapy resistant><cytokine><determine efficacy><developmental><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><genomic effort><genomic strategy><hIRH><histologic image><histological image><improved><insight><intervention efficacy><leukemia><leukemia relapse><leukemia stem/initiating cells><leukemia treatment><leukemic progenitor><leukemic stem cell><leukemic therapy><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><migration><mouse model><murine model><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><patient derived xenograft model><patient oriented outcomes><pre-clinical trial><preclinical trial><progenitor capacity><progenitor cell like><progenitor cell niche><progenitor niche><progenitor-like><recurrent leukemia><relapse patients><resistance to therapy><resistant to therapy><response><scRNA sequencing><scRNA-seq><shelter><shelter housing><shelters><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell niche><stem cell characteristics><stem cell niche><stem cells><stem-like><stemness><stromal cell-derived factor-1alpha><substantia spongiosa><substantia trabecularis><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapeutic resistance><therapeutic target><therapy efficacy><therapy resistant><trabecular bone><transplant><treatment resistance><treatment strategy><tumor microenvironment>
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Yiqin Du

UNIVERSITY OF SOUTH FLORIDA, TAMPA, FL

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$455,810
FY 2026

Project Title

Mechanisms of Trabecular Meshwork Regeneration by Stem Cells

Grant Number:

5R01EY025643-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2015

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Glaucoma is a leading cause of irreversible blindness throughout the world and the second leading cause of blindness overall in the USA. Elevated intraocular pressure (IOP) and aging are the most important risk factors for most forms of glaucoma. IOP level is highly dependent on the ...

Research Terms

<Address><Aging><Aqueous Humor><Autoregulation><Blindness><Body Tissues><COX-2><COX2><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CXC-R4><CXCL12><CXCL12 gene><CXCL12 protein><CXCR-4><CXCR4><CXCR4 gene><Cas nuclease technology><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell Survival><Cell Viability><Cell-Extracellular Matrix><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellularity><Chemokine (C-X-C Motif) Ligand 12><Chemotactic Cytokines><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cornea><Cranial Nerve II><D2S201E><DNA mutation><Data><Deposit><Deposition><Dexamethasone><Dinoprostone><Drugs><ECM><Engraftment><Extracellular Matrix><FB22><Fat progenitor cell><Fat stem cell><Foundations><Funding><Genetic Change><Genetic defect><Genetic mutation><Glaucoma><Goals><HM89><HSY3RR><Home><Homeostasis><Homing><Homologous Chemotactic Cytokines><Human><Impairment><In Vitro><Injections><Integrin alpha-5 beta-1><Integrin alpha5beta1><Integrin α5β1><Intercrines><Intraocular Fluid><Intraocular Pressure><LAP3><LCR1><LESTR><Lead><MMPs><Matrix Metalloproteinases><Medication><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutation><NPY3R><NPYR><NPYRL><NPYY3R><Natural regeneration><Non-adherent patient><Nonadherent patient><Ocular Tension><Operative Procedures><Operative Surgical Procedures><Optic Nerve><PBSF><PGE2><PGE2 alpha><PGE2alpha><PGHS-2><PHS-2><PTGS2><PTGS2 gene><Pathologic><Pathway interactions><Patient Non Compliance><Patient Non-Adherence><Patient Nonadherence><Patient Noncompliance><Pattern><Pb element><Pharmaceutical Preparations><Phenotype><Physiologic Intraocular Pressure><Physiological Homeostasis><Platelet Glycoprotein Ic/IIa><Pre-B Cell Growth Stimulating Factor><Progenitor Cell Transplantation><Progenitor Cells><Prostaglandin E2><Prostaglandin E2 alpha><Prostaglandin E2alpha><RNA Seq><RNA sequencing><RNAseq><Regeneration><Rejuvenation><Resistance><Retinal Ganglion Cells><Risk Factors><SCYB12><SDF-1><SDF-1A><SDF-1B><SDF-1alpha><SDF1><SDF1A><SDF1B><SIS cytokines><SOX21><SOX21 gene><SOX25><SRY-Box 21><SRY-Related HMG-Box Gene 21><Sdf1 protein><Second Cranial Nerve><Site><Solid><Source><Stem Cell Transplantation><Stem Cell like><Stem cell transplant><Stromal Cell-Derived Factor 1><Subcellular Process><Surgical><Surgical Interventions><Surgical Procedure><TLSF-A><TLSF-B><TPAR1><Testing><Therapeutic><Tissues><Trabecular Meshwork><Trabecular meshwork structure><Transgenes><Transplantation><Treatment Efficacy><VLA-5><VLA-5 Receptors><WNT Signaling Pathway><WNT signaling><Work><adipocyte progenitors><adipocyte stem cell><adipocyte-derived stem cell><adipose derived stem cell><adipose progenitor><adipose stem cell><adipose tissue derived stem cell><adipose tissue stem cells><aged><aqueous><awake><chemoattractant cytokine><chemokine><clinical applicability><clinical application><clinical translation><clinically translatable><corneal><design><designing><drug/agent><effective therapy><effective treatment><endogenous progenitor><endogenous stem cells><experiment><experimental research><experimental study><experiments><fat derived stem cell><genome mutation><glaucomatous><hCOX-2><hIRH><heavy metal Pb><heavy metal lead><homes><in vivo><in vivo Model><inhibitor><intervention efficacy><intra-ocular pressure><laser photocoagulation><life span><lifespan><migration><mouse genetics><multipotency><multipotent><mutant><myocilin><nerve damage><pathway><preservation><prevent><preventing><progenitor capacity><progenitor cell based therapy><progenitor cell like><progenitor cell proliferation><progenitor cell regeneration><progenitor cell self renewal><progenitor cell therapy><progenitor cell treatment><progenitor proliferation><progenitor regeneration><progenitor self renewal><progenitor therapy><progenitor transplantation><progenitor treatment><progenitor-like><regenerate><regeneration potential><regenerative potential><repair><repaired><resistant><restoration><retinal ganglion><self-renew><self-renewal><side effect><stem and progenitor cell proliferation><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor cell therapy><stem and progenitor cell transplantations><stem cell based therapy><stem cell characteristics><stem cell mediated therapy><stem cell proliferation><stem cell regeneration><stem cell self renewal><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><stem-like><stemness><stromal cell-derived factor-1alpha><stromal progenitor><stromal stem cell><surgery><therapeutic efficacy><therapy efficacy><transcriptome sequencing><transcriptomic sequencing><transgene><transplant><vision loss><visual loss>
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Karen M Mann

H. LEE MOFFITT CANCER CTR & RES INST, TAMPA, FL

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$441,529
FY 2026

Project Title

RBFOX2 deregulation promotes pancreatic cancer progression through alternative splicing

Grant Number:

5R01CA279713-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Splicing is a critical biological process in cancer initiation and progression. In pancreatic cancer, few studies have investigated the role of splicing regulators or their spliced targets in disease progression. Using a high- throughput, genome-wide genetic screen in vivo for novel events p...

Research Terms

<Abscission><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Antisense Agent><Antisense Oligonucleotides><Automobile Driving><Biological><Biological Function><Biological Process><C-K-RAS><CLIP-Seq><Cancer Center><Cancer Control><Cancer Control Science><Cancers><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Line><Cell Locomotion><Cell Migration><Cell Movement><CellLine><Cells><Cellular Expansion><Cellular Growth><Cellular Migration><Cellular Motility><Complementary DNA><Coupled><Data><Diagnosis><Differentation Markers><Differentiation Antigens><Differentiation Markers><Disease><Disease Outcome><Disease Progression><Disorder><Disseminated Malignant Neoplasm><Down-Regulation><ES cell><ES cell differentiation><ESC differentiation><Event><Evolution><Excision><Exclusion><Exhibits><Exons><Extirpation><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Generalized Growth><Genetic Screening><Growth><HITS-CLIP><Hepatic Neoplasm Secondary><Hepatic metastasis><High-throughput sequencing of CLIP cDNA library><Human><Immune Precipitation><Immunoprecipitation><Incidence><Intervention><Invaded><Isoforms><K-RAS2A><K-RAS2B><K-Ras><K-Ras 2A><K-Ras-2 Oncogene><KRAS><KRAS2><KRAS2 gene><Ki-RAS><L-Serine><L-Threonine><Link><Liquid Chromatography><Liver secondaries><Liver secondary cancer><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant neoplasm of pancreas><Marker Antigens><Mediating><Metastasis><Metastasize><Metastatic Cancer><Metastatic Lesion><Metastatic Malignant Neoplasm><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Liver><Metastatic Tumor><Metastatic Tumor to the Liver><Metastatic malignant neoplasm to liver><Modeling><Modern Man><Modification><Molecular><Motility><Neoplasm Metastasis><Nuclear><Oncogene K-Ras><Oncogenic><Outcome><PDAC cancer cell><PDAC cell><PDX model><Pancreas Cancer><Pancreas Ductal Adenocarcinoma><Pancreas Neoplasms><Pancreas Tumor><Pancreatic Cancer><Pancreatic Ductal Adenocarcinoma><Pancreatic Tumor><Pathogenicity><Patient derived xenograft><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phenotype><Phosphorylation Inhibition><Phosphorylation Site><Play><Process><Progenitor Cells><Progression-Free Survivals><Protein Isoforms><Proteins><Proteomics><RASK2><RNA Seq><RNA Splicing><RNA sequencing><RNA-Binding Proteins><RNAseq><Recurrence><Recurrent><Recurrent Malignant Neoplasm><Recurrent Malignant Tumor><Recurrent disease><Regulation><Relapse><Relapsed Disease><Removal><Role><Secondary Neoplasm><Secondary Tumor><Serine><Splicing><Stem Cell like><Strains Cell Lines><Surgical Removal><Testing><Threonine><Tissue Arrays><Tissue Chip><Tissue Growth><Tissue Microarray><Transcript><Tumor Suppressor Proteins><Tyrosine Phosphorylation><Work><antisense oligo><biologic><cDNA><cancer cell differentiation><cancer initiation><cancer metastasis><cancer progenitor><cancer progenitor cells><cancer progression><cancer recurrence><cancer stem cell><cancer stem like cell><cell growth><cell motility><cellular differentiation><cohort><crosslinking and immunoprecipitation sequencing><cultured cell line><defined contribution><differentiation in embryonic stem cells><driving><effective therapy><effective treatment><embryo derived stem cell><embryonal stem cells><embryonic precursor differentiation><embryonic progenitor><embryonic stem cell><embryonic stem cell differentiation><exon skipping><flow cytophotometry><genome scale><genome-wide><genomewide><hESC><human ES cell><human ESC><human embryonic stem cell><iPS><iPSC><iPSCs><improved><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><liver metastases><malignancy><malignant liver neoplasm, specified as secondary><malignant progenitor><malignant stem cell><metastasis in the liver><metastasis to the liver><metastasize to the liver><metastatic cancer to liver><metastatic liver><metastatic liver neoplasm><mouse model><murine model><neoplasm progression><neoplasm/cancer><neoplastic progression><novel><oncogenic progenitor><oncogenic stem cells><ontogeny><pancreatic cancer patients><pancreatic ductal adenocarcinoma cell><pancreatic malignancy><pancreatic neoplasia><pancreatic neoplasm><patient derived xenograft model><patient oriented outcomes><patients with pancreatic cancer><prevent><preventing><progenitor capacity><progenitor cell like><progenitor cell pool><progenitor cell population><progenitor like cancer cell><progenitor pool><progenitor population><progenitor-like><programs><resection><rho><scRNA sequencing><scRNA-seq><secondary liver malignancy><secondary malignant liver neoplasm><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spheroids><stem and progenitor cell population><stem cell characteristics><stem cell of embryonic origin><stem cell pool><stem cell population><stem cells><stem like cancer cell><stem-like><stemness><tandem mass spectrometry><transcriptome sequencing><transcriptomic sequencing><tumor><tumor cell metastasis><tumor growth><tumor progression><tumor suppressor><v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog>
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Brandon K Hadland

FRED HUTCHINSON CANCER CENTER, SEATTLE, WA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$440,000
FY 2026

Project Title

Dormancy-dependent determination of hematopoietic stem cell fate from hemogenic endothelium

Grant Number:

5R01HL168110-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Title: Dormancy-dependent determination of hematopoietic stem cell fate from hemogenic endothelium Project Summary/Abstract: Hematopoietic stem cells (HSCs), uniquely defined by their simultaneous capacity for multilineage blood cell formation and life-long self-renewal, represent a valuable resourc...

Research Terms

<Address><Arteries><Assay><Bioassay><Biological Assay><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Blood Vessels><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CXC-R4><CXCL12><CXCL12 gene><CXCL12 protein><CXCR-4><CXCR4><CXCR4 gene><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Division Cycle><Cell Signaling><Cell Therapy><Cells><Cellular Assay><Chemokine (C-X-C Motif) Ligand 12><Chemokine Receptor Gene><Chemotactic Cytokines><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Cytotoxic cell><D2S201E><Development><Dose><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Endothelium><Endowment><Engraftment><Expression Signature><FB22><Gene Expression><Gene Expression Profile><Gene Transcription><Generations><Genes><Genetic><Genetic Transcription><Goals><HM89><HSC Specification><HSC differentiation><HSC emergence><HSC formation><HSC production><HSC transplantation><HSY3RR><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic><Hematopoietic Cell Production><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Research><Hematopoietic Stem Cell Specification><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Homologous Chemotactic Cytokines><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><In Vitro><Instruction><Intercrines><Intracellular Communication and Signaling><K lymphocyte><Knowledge><LAP3><LCR1><LESTR><Laboratories><Life><Ligands><MYC Family Protein><MYC Protein><Measures><Mediating><Metabolic><Methods><Mice><Mice Mammals><Mitotic><Mitotic Activity><Modeling><Molecular><Murine><Mus><NK Cells><NPY3R><NPYR><NPYRL><NPYY3R><Natural Killer Cells><PBSF><Pathway interactions><Patients><Pluripotent Stem Cells><Pre-B Cell Growth Stimulating Factor><Production><Progenitor Cells><Property><Protocol><Protocols documentation><RNA Expression><Receptor Protein><Reproducibility><Research><Research Resources><Resolution><Resources><Role><SCYB12><SDF-1><SDF-1A><SDF-1B><SDF-1alpha><SDF1><SDF1A><SDF1B><SIS cytokines><Sdf1 protein><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Sorting><Specific qualifier value><Specified><Stem Cell Development><Stromal Cell-Derived Factor 1><Surface><T-Cells><T-Lymphocyte><TLSF-A><TLSF-B><TPAR1><Techniques><Testing><Therapeutic><Transcription><Transplantation><biological signal transduction><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell emergence><blood stem cell formation><blood stem cell transplantation><blood-forming stem cell><cell assay><cell based intervention><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chemoattractant cytokine><chemokine><chemokine receptor><combinatorial><developmental><differentiation of pluripotent stem cells><differentiation protocol><disease model><disorder model><emergence of hematopoietic stem cells><endothelial progenitor><endothelial progenitor cell><endothelial stem cell><gene expression pattern><gene expression signature><hIRH><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic differentiation><hematopoietic engraftment><hematopoietic progenitor><hematopoietic progenitor cell differentiation><hematopoietic progenitor cell fate><hematopoietic progenitor cell formation><hematopoietic progenitor cell transplantation><hematopoietic progenitor differentiation><hematopoietic progenitor formation><hematopoietic stem and progenitor cell fate><hematopoietic stem cell differentiation><hematopoietic stem cell emergence><hematopoietic stem cell fate><hematopoietic stem cell formation><hematopoietic stem cell production><hematopoietic stem progenitor cell><hematopoietic transplantation><hemogenic endothelium><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><human derived pluripotent stem cell><human pluripotent stem cell><in vivo><indexing><induced Cre><inducible Cre><innovate><innovation><innovative><insight><interest><life span><lifespan><loss of function><new approaches><novel approaches><novel strategies><novel strategy><pathway><pharmacologic><pluripotent progenitor><pluripotent stem cell differentiation><progenitor cell development><progenitor development><programs><protein expression><receptor><resolutions><scRNA sequencing><scRNA-seq><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell development><stem cells><stromal cell-derived factor-1alpha><success><thymus derived lymphocyte><transcriptional profile><transcriptional signature><transcriptomics><transplant><vascular>
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Xing Dai

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$431,750
FY 2026

Project Title

Intrinsic and extrinsic control of epithelial tissue stem cell activity

Grant Number:

5R35GM145307-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Tissue stem cells are rare, undifferentiated cells that are capable of self-renewal and are essential for fueling the homeostasis and regeneration of the tissue in which they reside. They are often quiescent, and when activated, they proliferate and differentiate to produce mature c...

Research Terms

<Address><Autoregulation><Basal Cell><Beta Cadherin-Associated Protein><Beta-1 Catenin><Biologic Models><Biological Models><Body Tissues><Breast Cancer><CUL-2><Cancer Cause><Cancer Etiology><Cell Body><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Signaling><Cells><Characteristics><Chromatin><Disease><Disorder><Epithelium><Event><Failure><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genetic Transcription><Heterogeneity><Homeostasis><Intracellular Communication and Signaling><Knowledge><Lineage Tracing><Macrophage><Malignant Breast Neoplasm><Malignant Cell><Mammary gland><Maps><Mesenchymal><Model System><Molecular><Molecular Target><Morphogenesis><Mφ><Natural regeneration><PRO2286><Physiological Homeostasis><Progenitor Cells><Proliferating><Prostate><Prostate Gland><Prostatic Gland><RNA Expression><Regeneration><Regenerative Medicine><Regulation><Research><Resting progenitor><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Skin><Stem Cell Assay><Technology><Testing><Tissue Engineering><Tissues><Transcription><Undifferentiated><basal progenitor><basal stem cell><beta cat><beta catenin><bioengineered tissue><biological signal transduction><breast epithelium><cancer cell><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular lineage mapping><cellular lineage tracking><clinical relevance><clinically relevant><dormant stem cell><engineered tissue><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><in vivo><inactive stem cell><innovate><innovation><innovative><insight><interdisciplinary approach><knockout gene><latent progenitor><latent stem cell><malignant breast tumor><mammary><mammary epithelium><morphogenetic process><multidisciplinary approach><novel><prevent><preventing><progenitor biology><progenitor cell assay><progenitor cell biology><progenitor cell gene><progenitor gene><programs><quiescent progenitor><quiescent stem cells><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regenerative><resting stem cell><self-renew><self-renewal><single cell genomics><single cell next generation sequencing><single cell sequencing><stem and progenitor biology><stem cell biology><stem cell depletion><stem cell exhaustion><stem cell fatigue><stem cell genes><stem cell quiescence><stem cell-based assay><stem cells><tissue progenitor><tissue regeneration><tissue regrowth><tissue renewal><tissue specific progenitor cells><tissue specific regeneration><tissue specific stem cells><tissue stem cells><β-catenin>
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Tai-Yen Chen

UNIVERSITY OF HOUSTON, HOUSTON, TX

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$431,750
FY 2026

Project Title

Deciphering the Role of CTR1 Oligomeric States in Copper Homeostasis and Neuronal Differentiation

Grant Number:

1R35GM161380-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This proposal aims to elucidate how the dynamic oligomeric transitions of Copper Transporter 1 (CTR1) couple copper (Cu) homeostasis with neuronal developmental pathways. Cu is an essential micronutrient for neuronal function, and a deficiency of Cu in early life can have devastating...

Research Terms

<Address><Allosteric Regulation><Assay><Automobile Driving><Autoregulation><Bioassay><Biochemical><Biological Assay><Brain Diseases><Brain Disorders><Cell Body><Cells><Collaborations><Copper><Cu element><Degenerative Neurologic Disorders><Development><Diagnostic><Disease><Disorder><Encephalon Diseases><Endocytosis><Ensure><Event><Future><Genetic><Growth Agents><Growth Factor><Growth Substances><Health><Homeostasis><Impairment><In Situ><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Life><Link><Mediating><Membrane><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Methodology><Micronutrients><Microscopy><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurobiology><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuronal Differentiation><Neuronal Transmission><Neurons><Pathway interactions><Physiologic><Physiological><Physiological Homeostasis><Proteins><Proteins Growth Factors><Proteomics><R-Series Research Projects><R01 Mechanism><R01 Program><Regulation><Research><Research Grants><Research Project Grants><Research Projects><Role><Signal Pathway><Stem Cell Research><Study models><Surface Proteins><System><Therapeutic><Visualization><axon signaling><axon-glial signaling><axonal signaling><copper transporter 1><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><driving><glia signaling><glial signaling><hESC><hESC model><human ES cell><human ESC><human embryonic stem cell><human embryonic stem cell based model><human embryonic stem cell derived model><human embryonic stem cell model><human progenitor><human stem cells><innovate><innovation><innovative><insight><membrane structure><molecular imaging><molecule imaging><monomer><multidisciplinary><mutant><nerve signaling><neural signaling><neurobiological><neurodegenerative illness><neuronal><neuronal signaling><neurotransmission><novel><overexpress><overexpression><pathway><progenitor cell differentiation><progenitor cell model><progenitor differentiation><progenitor model><single molecule><social role><stem and progenitor cell model><stem and progenitor differentiation><stem cell based model><stem cell derived model><stem cell differentiation><stem cell model><stem cell study><stoichiometry><trafficking><uptake>
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Heather Christofk

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$423,791
FY 2026

Project Title

Metabolic Control of Hair Follicle Stem Cell Homeostasis and Tumorigenesis

Grant Number:

5R01AR084245-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/11/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract In the last five years, we discovered a functional role for glycolytic metabolism in HFSC homeostasis. We found that lactate dehydrogenase (Ldh) activity is essential for HFSC activation, and that elevation of Ldh activity through blockade of pyruvate entry into mitochondria can promote HFS...

Research Terms

<Acceleration><Affect><Alopecia><Baldness><Cancers><Carcinoma><Cell Body><Cells><Coupling><DMBA><Data><EC 1.1.1.27><Electrons><Enzyme Gene><Enzymes><Epidermis><Epidermoid Carcinoma><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelial cancer><Gene Expression><Generalized Growth><Genetic><Genetic Models><Gln><Glutamine><Grant><Growth><Hair><Hair Follicle><Hair follicle structure><Intermediary Metabolism><KO mice><Knock-out Mice><Knockout Mice><L-Glutamine><L-Lactate Dehydrogenase><L-Lactic Acid Dehydrogenase><Lactate Dehydrogenase><Left><Malignant Cell><Malignant Epithelial Neoplasms><Malignant Epithelial Tumors><Malignant Neoplasms><Malignant Tumor><Metabolic><Metabolic Control><Metabolic Pathway><Metabolic Processes><Metabolism><Mitochondria><Molecular><NAD-Lactate Dehydrogenase><NADH><Negative Beta Particle><Negatrons><Normal Tissue><Normal tissue morphology><Null Mouse><Oncogenesis><Oxidation-Reduction><Pathway interactions><Planocellular Carcinoma><Play><Position><Positioning Attribute><Production><Progenitor Cells><Pyruvate><Q Levoglutamide><Q. Levoglutamide><Redox><Regulation><Role><Signaling Molecule><Squamous Carcinoma><Squamous Cell Epithelioma><Squamous cell carcinoma><Testing><Time><Tissue Growth><Topical Drug Administration><Topical application><Tumor Promotion><Work><Wound Repair><apply topically><cancer cell><cancer initiation><cancer progression><chemical carcinogenesis><cofactor><deliver topically><dimethylbenz(a)anthracene><dimethylbenzanthracene><enzyme activity><enzyme substrate><epigenetically><epithelial carcinoma><flexibility><flexible><gain of function><lactic acid dehydrogenase><loss of function><malignancy><mitochondrial><neoplasm progression><neoplasm/cancer><neoplastic progression><ontogeny><oxidation><oxidation reduction reaction><pathway><pharmacologic><prevent><preventing><progenitor cell fate><progenitor cell homeostasis><progenitor cell maintenance><progenitor fate><progenitor maintenance><social role><stem and progenitor cell fate><stem cell fate><stem cell homeostasis><stem cell maintenance><stem cells><tool><topical administration><topical delivery><topical drug application><topical drug delivery><topical instillation><topical treatment><treat topically><tumor><tumor initiation><tumor progression><tumorigenesis><wound healing><wound recovery><wound resolution>
View Full Project Details on NIH Reporter
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William E Lowry

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$423,791
FY 2026

Project Title

Metabolic Control of Hair Follicle Stem Cell Homeostasis and Tumorigenesis

Grant Number:

5R01AR084245-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/11/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract In the last five years, we discovered a functional role for glycolytic metabolism in HFSC homeostasis. We found that lactate dehydrogenase (Ldh) activity is essential for HFSC activation, and that elevation of Ldh activity through blockade of pyruvate entry into mitochondria can promote HFS...

Research Terms

<Acceleration><Affect><Alopecia><Baldness><Cancers><Carcinoma><Cell Body><Cells><Coupling><DMBA><Data><EC 1.1.1.27><Electrons><Enzyme Gene><Enzymes><Epidermis><Epidermoid Carcinoma><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelial cancer><Gene Expression><Generalized Growth><Genetic><Genetic Models><Gln><Glutamine><Grant><Growth><Hair><Hair Follicle><Hair follicle structure><Intermediary Metabolism><KO mice><Knock-out Mice><Knockout Mice><L-Glutamine><L-Lactate Dehydrogenase><L-Lactic Acid Dehydrogenase><Lactate Dehydrogenase><Left><Malignant Cell><Malignant Epithelial Neoplasms><Malignant Epithelial Tumors><Malignant Neoplasms><Malignant Tumor><Metabolic><Metabolic Control><Metabolic Pathway><Metabolic Processes><Metabolism><Mitochondria><Molecular><NAD-Lactate Dehydrogenase><NADH><Negative Beta Particle><Negatrons><Normal Tissue><Normal tissue morphology><Null Mouse><Oncogenesis><Oxidation-Reduction><Pathway interactions><Planocellular Carcinoma><Play><Position><Positioning Attribute><Production><Progenitor Cells><Pyruvate><Q Levoglutamide><Q. Levoglutamide><Redox><Regulation><Role><Signaling Molecule><Squamous Carcinoma><Squamous Cell Epithelioma><Squamous cell carcinoma><Testing><Time><Tissue Growth><Topical Drug Administration><Topical application><Tumor Promotion><Work><Wound Repair><apply topically><cancer cell><cancer initiation><cancer progression><chemical carcinogenesis><cofactor><deliver topically><dimethylbenz(a)anthracene><dimethylbenzanthracene><enzyme activity><enzyme substrate><epigenetically><epithelial carcinoma><flexibility><flexible><gain of function><lactic acid dehydrogenase><loss of function><malignancy><mitochondrial><neoplasm progression><neoplasm/cancer><neoplastic progression><ontogeny><oxidation><oxidation reduction reaction><pathway><pharmacologic><prevent><preventing><progenitor cell fate><progenitor cell homeostasis><progenitor cell maintenance><progenitor fate><progenitor maintenance><social role><stem and progenitor cell fate><stem cell fate><stem cell homeostasis><stem cell maintenance><stem cells><tool><topical administration><topical delivery><topical drug application><topical drug delivery><topical instillation><topical treatment><treat topically><tumor><tumor initiation><tumor progression><tumorigenesis><wound healing><wound recovery><wound resolution>
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George Thomas Eisenhoffer

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$421,200
FY 2026

Project Title

Regulation of Overall Cell Numbers During Epithelial Tissue Homeostasis and Pathogenesis

Grant Number:

5R35GM149226-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Cellular turnover is essential for the form and function of epithelial tissues. The rate of cell turnover slows during aging, can be accelerated during injury and repair, and is precociously stimulated during carcinogenesis; but the mechanisms guiding it in living tissues is...

Research Terms

<Acceleration><Actomyosin><Address><Aging><Area><Autoregulation><Body Tissues><Brachydanio rerio><Cancer Induction><Cell Body><Cell Count><Cell Growth in Number><Cell Multiplication><Cell Number><Cell Proliferation><Cells><Cellular Proliferation><Complex><Danio rerio><Data><EGF Receptor><EGFR><ERBB Protein><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelial Cells><Epithelium><Event><Gene Transcription><Genetic Transcription><Goals><HER1><Homeostasis><Human><Immune><Immunes><Individual><Inflammatory><Innate Immune System><Knowledge><Ligands><Link><Lipids><Maintenance><Modern Man><Molecular><Organism><Pathogenesis><Physiological Homeostasis><Process><Progenitor Cells><Proliferating><RNA Expression><Recombinants><Regulation><Role><Signal Induction><Stimulus><TGF-alpha Receptor><Testing><Tissues><Transcription><Transforming Growth Factor alpha Receptor><Urogastrone Receptor><Visualization><Work><Zebra Danio><Zebra Fish><Zebrafish><c-erbB-1><c-erbB-1 Protein><carcinogenesis><epigen><epigenetically><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><injury and repair><insight><living system><mechanical properties><new approaches><novel approaches><novel strategies><novel strategy><prevent><preventing><progenitor cell proliferation><progenitor proliferation><proto-oncogene protein c-erbB-1><recruit><response><social role><sphingosine 1-phosphate><stem and progenitor cell proliferation><stem cell proliferation><stem cells><tool>
View Full Project Details on NIH Reporter
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Wenquan Ou

UNIV OF MARYLAND, COLLEGE PARK, COLLEGE PARK, MD

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$416,785
FY 2026

Project Title

Multiscale hydrogel biomaterials-enabled 3D modeling of cancer drug resistance

Grant Number:

5R01CA279815-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Developing new anticancer drugs has been very slow and costly. A major reason is that the commonly used 2D cancer cells and animal models for drug discovery today are very different from the 3D tumors in human patients. Lately, 3D tumor models have been made by suspending t...

Research Terms

<3-D><3-D modeling><3-Dimensional><3D><3D cell culture><3D culture><3D modeling><Acceleration><American><Animal Cancer Model><Animal Model><Animal Models and Related Studies><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><BM Stem Cell><BM derived progenitor><BM progenitor><BM- derived Stem Cells><Biocompatible Materials><Biomaterials><Blood Vessel Tumor><Blood Vessels><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Marrow Stem Cell><Bone Marrow progenitor><Breast Cancer><Breast Cancer Cell><Breast Cancer Patient><Breast Neoplasms><Breast Tumor Patient><Breast Tumors><Cancer Cause><Cancer Drug><Cancer Etiology><Cancer Induction><Cancer Patient><Cancers><Cardiac><Cause of Death><Cell Body><Cell Culture Techniques><Cell Isolation><Cell Line><Cell Locomotion><Cell Migration><Cell Movement><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Survival><Cell Viability><Cell model><CellLine><Cells><Cellular Migration><Cellular Motility><Cellular Spheroids><Cellular model><Cessation of life><Chemotherapy Protocol><Chemotherapy Regimen><Chemotherapy-Oncologic Procedure><Chondrocytes><Collagen><Collecting Cell><Combination Chemotherapy Regimen><Complex><Data><Death><Devices><Drug Modelings><Drug resistance><EGF Receptor><EGFR><ERBB Protein><Embryo><Embryonic><Encapsulated><Endothelial Cells><Endothelium><Engineering><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><Failure><Fat progenitor cell><Fat stem cell><Fats><Fatty acid glycerol esters><Foundations><Frequencies><Gene Expression><HER1><Histology><Home><Human><Human Figure><Human body><Hydrogels><In Vitro><Individual><Label><MDA MB 231><MDA-231><MDA-MB231><Malignant Breast Neoplasm><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mammary Cancer><Mammary Neoplasms><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Methods><Mice><Mice Mammals><Microcapsules drug delivery system><Microfluidics><Modeling><Modern Man><Multicellular Spheroids><Murine><Mus><Nature><Neoplasm Metastasis><Neoplasms in Vascular Tissue><Neoplastic Colony-Forming Units><Neoplastic Disease Chemotherapeutic Agents><Neoplastic Stem Cells><Nutrient><O element><O2 element><Oncogenesis><Organoids><Osteoblasts><Ovarian Tumor><Ovary Neoplasms><Ovary Tumor><Oxygen><Patients><Perfusion><Permeability><Play><Pluripotent Stem Cells><Progenitor Cells><Proliferating><Property><Prostate Neoplasms><Prostate Tumor><Prostatic Neoplasia><Prostatic Neoplasms><Public Health><Quimioterapia><Recurrent Malignant Neoplasm><Recurrent Malignant Tumor><Reporting><Role><Secondary Neoplasm><Secondary Tumor><Strains Cell Lines><Stromal Cells><Study models><Surface><Suspension Culture><TGF-alpha Receptor><TNBC><Technology><Testing><Time><Tissues><Totipotency><Totipotent><Transforming Growth Factor alpha Receptor><Tumor Cell><Tumor Stem Cells><Tumor-Specific Treatment Agents><Umbilical vein><Urogastrone Receptor><Vascular Neoplasms><Vascular Tissue Tumor><Vascular Tumor><Vascularization><Woman><adipocyte progenitors><adipocyte stem cell><adipocyte-derived stem cell><adipose derived stem cell><adipose progenitor><adipose stem cell><adipose tissue derived stem cell><adipose tissue stem cells><anti-cancer drug><biological material><blood vessel neoplasm><bone marrow derived progenitor><bone marrow derived stem cells><bone marrow stromal cell><bone marrow stromal stem cell><breast tumor cell><c-erbB-1><c-erbB-1 Protein><cancer cell><cancer cell differentiation><cancer chemotherapy><cancer drug resistance><cancer metastasis><cancer progenitor><cancer progenitor cells><cancer recurrence><cancer stem cell><cancer stem like cell><cancer sub-types><cancer subtypes><cancers that are rare><carcinogenesis><cell culture><cell cultures><cell motility><cell sorting><cell type><combat><cost><cultured cell line><drug discovery><drug resistant><engineered progenitor cells><engineered stem cells><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><fat derived stem cell><hatching><homes><human progenitor><human stem cells><in vivo><individuals with breast cancer><innovate><innovation><innovative><malignancy><malignant breast tumor><malignant progenitor><malignant stem cell><mammary tumor><microcapsule><model of animal><mortality><nano litre><nanoliter><nanolitre><neoplasm/cancer><neoplastic cell><neural><new anti-cancer agent><new anticancer agent><new anticancer drug><new antineoplastic><new cancer drug><novel><novel anti-cancer agent><novel anti-cancer drug><novel anticancer agent><novel anticancer drug><novel antineoplastic><novel cancer drug><oncogenic progenitor><oncogenic stem cells><osteogenic><ovarian neoplasm><patients with breast cancer><person with breast cancer><pluripotent progenitor><progenitor like cancer cell><protein expression><proto-oncogene protein c-erbB-1><rare cancer><rare malignancy><rare tumor><resistance to Drug><resistance to cancer drugs><resistant to Drug><resistant to cancer drugs><scaffold><scaffolding><social role><spheroids><stem cells><stem like cancer cell><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><three dimensional><three dimensional cell culture><three-dimensional modeling><triple-negative breast cancer><triple-negative invasive breast carcinoma><tumor><tumor cell metastasis><tumor progenitor><tumorigenesis><tumorigenic><vascular><µfluidic>
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Tudorita Tumbar

CORNELL UNIVERSITY, ITHACA, NY

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$414,529
FY 2026

Project Title

Investigating the coordinated endothelial-epithelial interactions in adult hair cycle of mouse skin

Grant Number:

5R01AR081021-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/28/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Highly regenerative tissues such as blood and skin may utilize blood vessels as dual players in tissue growth functions: one in supplying O2/nutrients and another in regulating tissue stem cell activity via signaling. Correlative evidence suggest that skin endothelial cells may act as signa...

Research Terms

<21+ years old><Ablation><Address><Adult><Adult Human><Affect><Arteries><Attention><Autoregulation><BMP4><Behavior><Blood><Blood Reticuloendothelial System><Blood Vessels><Blood capillaries><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Signaling><Cell to Cell Communication and Signaling><Cell-Cell Signaling><Cells><Cessation of life><Communication><DNA mutation><Data><Death><Defect><Disease><Disorder><Endothelial Cells><Endothelium><Epithelial Cells><Epithelium><Exercise><Expression Signature><Future><Gene Expression><Gene Expression Profile><Gene Targeting><Generalized Growth><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetic study><Genomic approach><Growth><Hair><Hair Follicle><Hair follicle structure><Hematopoietic><Hereditary hemorrhagic telangiectasia><Homeostasis><Human><Intracellular Communication and Signaling><Laboratories><Lymphatic><Maintenance><Maps><Mice><Mice Mammals><Modern Man><Molecular><Morphology><Murine><Mus><Mutation><Nutrient><Osler-Rendu Disease><Osler-Weber-Rendu Disease><Physiologic><Physiological><Physiological Homeostasis><Play><Process><Progenitor Cells><Proliferating><Regenerative research><Regulation><Resting progenitor><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Skin><Skin tissue regeneration><TGF Beta Signaling Pathway><TGF-beta Receptors><TGF-β Receptors><TGF-β Signaling Pathway><Testing><Time><Tissue Growth><Tissues><Transforming Growth Factor beta Receptors><Transforming Growth Factor β Receptors><Veins><Work><adulthood><biological signal transduction><capillary><dermis regeneration><dormant stem cell><epidermal regeneration><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><experiment><experimental research><experimental study><experiments><gene expression pattern><gene expression signature><genetic approach><genetic strategy><genome mutation><genomic effort><genomic strategy><hemopoietic><human disease><inactive stem cell><intercellular communication><latent progenitor><latent stem cell><lymph channel><lymph vessel><lymphatic channel><lymphatic vessel><mouse genetics><mouse model><murine model><neural><notch><notch protein><notch receptors><novel><ontogeny><progenitor cell niche><progenitor niche><quiescent progenitor><quiescent stem cells><regenerate new tissue><regenerate skin><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration research><regeneration studies><regenerative studies><regenerative tissue><resting stem cell><skin regeneration><social role><stem and progenitor cell niche><stem cell niche><stem cell quiescence><stem cells><tissue progenitor><tissue regeneration><tissue regrowth><tissue renewal><tissue specific progenitor cells><tissue specific regeneration><tissue specific stem cells><tissue stem cells><transcriptional profile><transcriptional signature><vascular>
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Jefferson Chan

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$411,542
FY 2026

Project Title

Chemical Probes for Studying Stem Cells and Environmental Interactions in Aging

Grant Number:

5R35GM133581-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2019

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary / Abstract Stem cells are critical cell populations that maintain tissue health and regenerative capacity. Understanding the mechanisms leading to the decline of stem cell function can provide unique insights into how their regenerative abilities can be enhanced and prolonged to faci...

Research Terms

<Address><Aging><Aldehydes><Animals><Biological Markers><Biology><Body Tissues><Cell Aging><Cell Body><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Chemicals><Detection><Development><Environment><Enzyme Gene><Enzymes><Health><Hypoxia><Hypoxic><Inflammation><Life><Methods><Molecular Probes><Non-Invasive Detection><Noninvasive Detection><O element><O2 element><Oxidative Stress><Oxygen><Oxygen Deficiency><Play><Population><Process><Progenitor Cells><Proxy><Regenerative capacity><Replicative Senescence><Research><Role><Stem Cell Research><Tissues><Visualization><age associated effects><age effect><age related effects><aging effect><bio-markers><biologic marker><biomarker><design><designing><developmental><healthy aging><healthy human aging><impact of age><in vivo><influence of age><innovate><innovation><innovative><insight><molecular imaging><molecule imaging><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><progenitor aging><progenitor cell aging><progenitor cell function><progenitor function><regeneration ability><regeneration capacity><regenerative><replicative aging><social role><stem and progenitor cell function><stem and progenitor function><stem cell aging><stem cell function><stem cell study><stem cells><tool>
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Maurizio Chioccioli

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$411,086
FY 2026

Project Title

Defining the cellular dynamics that orchestrate alveolar epithelial cell repair behaviors in live mammal

Grant Number:

5R01HL162629-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: The mammalian lung has the capacity to repair itself following various injuries. Alveolar repair is a dynamic and coordinated process whereby stem/progenitor cells in the lung undergo differentiation into specialized cells to repair the damaged epithelium. Recent studies have uncove...

Research Terms

<AGTR2><AGTR2 gene><AT2><Affect><Alveolar><Alveoli progenitor><Alveoli stem cell><Basal Transcription Factor><Basal transcription factor genes><Behavior><Biology><Cell Body><Cells><Chromatin><Clinical><Code><Coding System><Data><Data Set><Distal><Epithelial Cells><Epithelium><Exhibits><Gene Expression><General Transcription Factor Gene><General Transcription Factors><Heterogeneity><Human><Image><In vivo analysis><Individual><Injury><Label><Lineage Tracing><Lung><Lung Alveolar Epithelia><Lung Diseases><Lung Respiratory System><Lung damage><Machine Learning><Mammalia><Mammals><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Molecular Target><Murine><Mus><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Outcome><Pathway interactions><Process><Progenitor Cells><Pulmonary Diseases><Pulmonary Disorder><Pulmonary imaging><Regulatory Regions><Reporting><Resolution><Source><Specific qualifier value><Specified><System><Techniques><Testing><Therapeutic Intervention><Time><Transcription Factor Proto-Oncogene><Transcription factor genes><Work><airway epithelial stem cells><airway progenitor><airway stem cells><alveolar epithelium><alveolar progenitor><alveolar stem cell><cell behavior><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular behavior><cellular lineage mapping><cellular lineage tracking><cellular targeting><combinatorial><computer based prediction><disease of the lung><disorder of the lung><gene regulatory network><genetic regulatory element><human disease><imaging><imaging system><in vivo><in vivo evaluation><in vivo regeneration><in vivo testing><injured><injuries><intervention therapy><lung disorder><lung imaging><lung injury><lung progenitor><lung repair><lung scanning><lung stem cell><lung tissue repair><lung tissue stem cell><lung-specific stem cell><machine based learning><molecular profile><molecular signature><multiomics><multiple omics><novel><panomics><pathway><predictive modeling><progenitor><progenitor cell differentiation><progenitor cell pool><progenitor cell population><progenitor cells in the lung><progenitor differentiation><progenitor pool><progenitor population><progenitors in the lung><pulmonary damage><pulmonary injury><pulmonary progenitor><pulmonary repair><pulmonary stem cell><pulmonary tissue damage><pulmonary tissue injury><repair><repaired><resolutions><respiratory progenitor><respiratory stem cell><scATAC sequencing><scATAC-seq><scRNA sequencing><scRNA-seq><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell sequencing assay for transposase accessible chromatin><single cell transcriptomic profiling><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell RNA sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><spatial and temporal><spatial temporal><spatiotemporal><stem><stem and progenitor cell population><stem and progenitor differentiation><stem cell differentiation><stem cell pool><stem cell population><stem cells><stem cells in the airway><stem cells in the lung><transcription factor>
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Andrew Salim Khalil

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$398,144
FY 2026

Project Title

Engineering Immunocompetent Systems for Modeling, Modulating, and Treating Inflammatory Diseases

Grant Number:

1R35GM162637-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Dysregulated inflammation is a central driver of a significant fraction of all human diseases, including chronic metabolic conditions, tumor metastasis, autoimmune disorders, and aging. Despite numerous advancements in tissue engineering and disease modeling, our ability to accurately captu...

Research Terms

<Adipose tissue><Aging><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Autoimmune Diseases><Beds><Behavior><Biologic Models><Biological Models><Biology><Blood Vessels><Body Tissues><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas9 screen><Cell Body><Cells><Chronic><Clinical><Cryofixation><Cryopreservation><Dependence><Development><Disease><Disorder><Engineering><Exhibits><Fatty Tissue><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Human><Immune><Immune mediated therapy><Immunes><Immunocompetent><Immunologically Directed Therapy><Immunomodulation><Immunotherapy><In Vitro><Inflammation><Inflammatory><Lineage Tracing><Link><Liver><Macrophage><Mediating><Metabolic><Metabolic Diseases><Metabolic Disorder><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Model System><Modeling><Modern Man><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><Mφ><Neoplasm Metastasis><Phenotype><Physiologic><Physiological><Physiology><Procedures><Process><Recombinant Cytokines><Recombinant DNA Technology><Research><Rest><Retrieval><Secondary Neoplasm><Secondary Tumor><Skeletal Muscle><System><Testing><Therapeutic><Thesaurismosis><Tissue Engineering><Tissue Model><Tissues><Voluntary Muscle><adipose><autoimmune condition><autoimmune disorder><autoimmunity disease><bioengineered tissue><bioprocess><cancer metastasis><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><clustered regularly interspaced short palindromic repeats screen><cold preservation><cold storage><developmental><disease model><disorder model><engineered immune system><engineered progenitor cells><engineered stem cells><engineered tissue><gene induction><genetically engineered><hepatic body system><hepatic organ system><human derived pluripotent stem cell><human disease><human pluripotent stem cell><human tissue><immune competent><immune engineering><immune modulation><immune regulation><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunoengineering><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><improved><in vivo><induction of genes><innovate><innovation><innovative><metabolism disorder><myeloid precursor><myeloid stem and progenitor cell><novel><progenitor><progenitor biology><progenitor cell biology><regenerative><stem and progenitor biology><stem cell biology><stem cell derived tissues><stem cell technology><systems research><tool><tumor><tumor cell metastasis><vascular><white adipose tissue><yellow adipose tissue>
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Peijing Jeremy Wang

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$382,143
FY 2026

Project Title

Epigenetic control of spermatogonial stem cell self-renewal

Grant Number:

5R01HD109253-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/5/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Males produce sperm continuously through adult life, driven by the renewal of spermatogonial stem cells (SSCs). The long-term objective of this application is to determine the role of a novel epigenetic program that we have recently identified in regulating the renewal of adult SSCs...

Research Terms

<21+ years old><ATAC sequencing><ATAC-seq><ATACseq><Adult><Adult Human><Animals><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biological><Biological Assay><Cannot achieve a pregnancy><Causality><Cell Body><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chemicals><Chromatin><Chromatin Remodeling Complex><Chromatin Remodeling Factor><DNA-Dependent RNA Polymerase II><Data><Difficulty conceiving><Dissection><Donor person><EC 2.1.1><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equilibrium><Etiology><Failure><Foundations><GDNF><GDNF gene><Gametes><Gene Cluster><Gene Expression><Gene Transcription><Gene Transfer Techniques><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genetic Transcription><Genetic study><Genome><Genomics><Germ Cells><Germ-Line Cells><HOX gene><Histone H3><Homeo Box Genes><Homeobox Family Gene><Homeobox Genes><Homeodoamin Gene><Homeotic Genes><Immune Precipitation><Immunoprecipitation><In Vitro><Infertility><Informal Social Control><Intrinsic factor><Life><Male Infertility><Malignant Cell><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Methylation><Methyltransferase><Mice><Mice Mammals><Molecular><Murine><Mus><Nucleosomes><PLZF><Play><Production><Progenitor Cell Transplantation><Progenitor Cells><Promyelocytic Leukemia Zinc Finger><Proteins><Proteomics><RNA Expression><RNA Polymerase B><RNA Polymerase II><RNA Seq><RNA sequencing><RNAseq><Regulation><Reproductive Cells><Reproductive Medicine><Research><Resolution><Role><Self Regulation><Sex Cell><Short interfering RNA><Small Interfering RNA><Sperm><Sperm stem cell><Spermatogenesis><Spermatozoa><Stem Cell Transplantation><Stem cell transplant><Testicles><Testis><Transcription><Transcription Activation><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activation><Transgenesis><Transplantation><ZBTB16><ZNF145><ZNF145 gene><Zinc Finger Protein 145><Zinc Finger- and BTB Domain-Containing Protein 16><adulthood><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><balance><balance function><biologic><cancer cell><causation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chromatin modifier><cytokine><disease causation><epigenetically><fertility cessation><fertility loss><germ stem cells><germline progenitor><germline progenitor cells><germline stem cells><glial cell-line derived neurotrophic factor><infertile><infertile males><infertile men><infertility in men><inhibitor><initial cell><innovate><innovation><innovative><insight><knock-down><knockdown><male><male factor infertility><male fertility><men facing infertility><men with infertility><methylase><multiomics><multiple omics><mutant><novel><panomics><progenitor biology><progenitor cell biology><progenitor cell division><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor cell regeneration><progenitor cell renewal><progenitor cell self renewal><progenitor division><progenitor niche><progenitor pool><progenitor population><progenitor regeneration><progenitor renewal><progenitor self renewal><progenitor transplantation><programs><recruit><resolutions><scATAC sequencing><scATAC-seq><scRNA sequencing><scRNA-seq><self-renew><self-renewal><sexual cell><siRNA><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell sequencing assay for transposase accessible chromatin><single cell transcriptomic profiling><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell RNA sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><social role><sperm cell><sperm progenitor><spermatogonia cell><spermatogonia progenitor><spermatogonia stem cells><spermatogonial cell><spermatogonial progenitor><spermatogonial stem cells><stem and progenitor biology><stem and progenitor cell division><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor cell regeneration><stem and progenitor cell renewal><stem and progenitor cell self renewal><stem and progenitor cell transplantations><stem cell biology><stem cell division><stem cell niche><stem cell pool><stem cell population><stem cell regeneration><stem cell renewal><stem cell self renewal><stem cells><stem cells in the germline><transcription factor><transcriptome sequencing><transcriptomic sequencing><translational applications><transmethylase><transplant><transplant donor><zoosperm><♂>
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Anil K Rustgi

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$377,932
FY 2026

Project Title

LIN28B promotes colorectal cancer differentiation and metastasis

Grant Number:

5R01CA277795-25

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2000

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Differentiation is a fundamental process underlying cellular identity and plasticity. Traditionally, differentiation is a transition between less committed/specialized cell states into more committed/specialized state, and this is believed to be unidirectional. Differentiation is evident in developm...

Research Terms

<Address><Admixture><Antioncogene Protein p53><Attenuated><Autoregulation><Bar Codes><Binding Proteins><CLDN1><Cancers><Cdx-2 protein><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Differentiation><Cell Differentiation process><Cell Division Cycle><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cell-Cell Adhesion><Cells><Cellular Function><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Cellular Regulation><Cellular Tumor Antigen P53><Circulation><Classification><Colon Cancer><Colon Carcinoma><Colonic Adenoma><Colonic Adenomatous Polyp><Colorectal Cancer><Complex><DNA mutation><Data><Dependence><Development><Distant><Drosophila Homolog of NOTCH 3><ES cell><ES cell differentiation><ESC differentiation><Embryo><Embryonic><Endowment><Equilibrium><Extravasation><Fostering><GI cancers><GI malignancies><GI tract cancers><Gastrointestinal Cancer><Gastrointestinal Tract Cancer><Gene Expression><Genetic><Genetic Change><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic defect><Genetic mutation><Health><Hepatic Neoplasm Secondary><Hepatic metastasis><Homeostasis><Human><Human Engineering><Hybrids><Implant><Injections><Intracellular Communication and Signaling><Intratumoral heterogeneity><Invaded><Leakage><Ligand Binding Protein><Ligand Binding Protein Gene><Lineage Tracing><Liver><Liver secondaries><Liver secondary cancer><Maintenance><Malignant><Malignant - descriptor><Malignant Gastrointestinal Neoplasm><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of gastrointestinal tract><Mediating><Messenger RNA><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Liver><Metastatic Tumor><Metastatic Tumor to the Liver><Metastatic malignant neoplasm to liver><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutation><NOTCH3><NOTCH3 gene><Neoplasm Metastasis><Occluding Junctions><Oncogenesis><Oncogenic><Oncoprotein p53><Organ><Outcome><P53><Phenotype><Phosphoprotein P53><Phosphoprotein pp53><Physiologic><Physiological><Physiological Homeostasis><Play><Portal Vein><Portal vein structure><Process><Proliferating><Property><Protein Binding><Protein TP53><Publishing><RNA Seq><RNA sequencing><RNA-Binding Proteins><RNAseq><Recombinant DNA Technology><Regulation><Role><Scheme><Secondary Neoplasm><Secondary Tumor><Signal Transduction><Signal Transduction Systems><Signaling><Spillage><Subcellular Process><Systematics><TP53><TP53 gene><TRP53><Therapeutic><Tight Junctions><Totipotency><Totipotent><Tumor Cell><Tumor Cell Invasion><Tumor Invasion><Tumor Protein p53><Tumor Protein p53 Gene><Zonula Occludens><adult progenitor><adult stem cell><attenuate><attenuates><balance><balance function><barcode><biological signal transduction><bound protein><cancer in the colon><cancer location><cancer metastasis><cancer progression><cancer site><cdx-2 gene product><cell growth regulation><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell metabolism><cellular differentiation><cellular lineage mapping><cellular lineage tracking><cellular metabaolism><claudin-1><claudin-1 protein><colon adenoma><colon adenomatous polyp><colon cancer cell line><colorectal cancer cell line><developmental><differentiation in embryonic stem cells><differentiation of pluripotent stem cells><embryo derived stem cell><embryonal stem cells><embryonic precursor differentiation><embryonic progenitor><embryonic stem cell><embryonic stem cell differentiation><gain of function><gastrointestinal malignancies><genetically engineered><genome mutation><hepatic body system><hepatic organ system><heterogeneity in tumors><iPS><iPSC><iPSCs><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><insight><intestinal epithelium><intra-tumoral heterogeneity><intratumor heterogeneity><knock-down><knockdown><liver metastases><loss of function><mRNA><malignancy><malignant liver neoplasm, specified as secondary><metastasis in the liver><metastasis to the liver><metastasize to the liver><metastatic cancer to liver><metastatic colo-rectal><metastatic colo-rectal cancer><metastatic colo-rectal carcinoma><metastatic colon cancer><metastatic colorectal><metastatic colorectal cancer><metastatic colorectal carcinoma><metastatic liver><metastatic liver neoplasm><mouse model><murine model><mutant><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><new marker><novel><novel biomarker><novel marker><overexpress><overexpression><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pharmacologic><pluripotency><pluripotent state><pluripotent stem cell differentiation><progenitor cell division><progenitor cell renewal><progenitor division><progenitor renewal><programs><protein p53><regeneration following injury><scRNA sequencing><scRNA-seq><secondary liver malignancy><secondary malignant liver neoplasm><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><somatic progenitor><somatic stem cell><stem and progenitor cell division><stem and progenitor cell renewal><stem cell division><stem cell of embryonic origin><stem cell renewal><transcription factor CDX2><transcriptome sequencing><transcriptomic sequencing><tumor><tumor cell metastasis><tumor heterogeneity><tumor progression><tumorigenesis>
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Jennifer Gillette

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$376,845
FY 2026

Project Title

Functional Role of Tetraspanin CD82 in Hematopoietic Stem Cell Interactions

Grant Number:

5R01HL122483-11

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2015

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The significant cellular demand of the hematopoietic system is maintained by a rare pool of tissue-specific, hematopoietic stem and progenitor cells (HSPCs) that are primarily found in a quiescent state. Upon hematopoietic stresses, such as significant bleeding, overwhelming infectio...

Research Terms

<4F9><Adhesions><Attenuated><Biochemistry><Biological Chemistry><Bleeding><Blood Precursor Cell><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone-Derived Transforming Growth Factor><C33><CD82><CD82 Gene><Cadherins><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Cycle><Cell Division Cycle><Cell Interaction><Cell Signaling><Cell-to-Cell Interaction><Cells><Complex><Coupled><Data><Development><Family><Foundations><GR15><HSC quiescence><Hand><Health><Hematologic Body System><Hematologic Organ System><Hematology><Hematopoietic><Hematopoietic Body System><Hematopoietic Progenitor Cells><Hematopoietic System><Hematopoietic stem cells><Hemorrhage><Human><IA4><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Individual><Infection><Injury><Integrins><Integrins Extracellular Matrix><Intracellular Communication and Signaling><KAI1><KAI1 gene><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><Ligands><Light><Link><Mediating><Membrane><Milk Growth Factor><Modern Man><Molecular><Mutation Analysis><Myelosuppressive Therapy><Natural regeneration><Null Mouse><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Phenotype><Photoradiation><Platelet Transforming Growth Factor><Publishing><Radiation exposure><Receptor Protein><Receptor Signaling><Recovery><Regeneration><Regenerative capacity><Regenerative response><Regulation><Research><Role><SAR2><ST6><Scaffolding Protein><Signal Transduction><Signal Transduction Systems><Signaling><Stress><TGF B><TGF-beta><TGF-beta Receptors><TGF-β><TGF-β Receptors><TGFbeta><TGFβ><Testing><Therapeutic><Tissues><Transforming Growth Factor beta><Transforming Growth Factor beta Receptors><Transforming Growth Factor β Receptors><Transforming Growth Factor-Beta Family Gene><Transforming Growth Factors><Tumor Growth Factors><Work><attenuate><attenuates><biological signal transduction><blood cell progenitor><blood loss><blood progenitor><blood stem cell><blood stem cell quiescence><blood-forming stem cell><combinatorial><developmental><exhaustion><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><hands><hematopoietic progenitor><hematopoietic stem cell quiescence><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><imaging><imaging approach><imaging based approach><improved><injuries><innovate><innovation><innovative><insight><membrane structure><mouse model><murine model><mutant><neutralizing antibody><novel><patient oriented outcomes><prevent><preventing><progenitor cell niche><progenitor cell regeneration><progenitor cell self renewal><progenitor niche><progenitor regeneration><progenitor self renewal><protein protein interaction><receptor><recruit><regenerate><regeneration ability><regeneration capacity><regeneration response><response><scaffold><scaffolding><single molecule><social role><spatial and temporal><spatial temporal><spatiotemporal><stem and progenitor cell niche><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell niche><stem cell regeneration><stem cell self renewal><therapeutic target><trafficking><transforming growth factors Animal growth regulators><transplant therapy><transplant treatment><transplantation therapy><transplantation treatment>
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Tianyan Gao

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$347,125
FY 2026

Project Title

Study of PTPRF-Mediated Regulation of Wnt Signaling

Grant Number:

5R01GM150200-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Protein phosphorylation defines one of the most important and pervasive regulatory mechanisms in cell signaling. A precise control of the balance between phosphorylation and dephosphorylation is crucial for living organisms to maintain normal physiological functions. While protein kinases ...

Research Terms

<3-D><3-Dimensional><3D><ATP-protein phosphotransferase><Attention><Attenuated><Automobile Driving><Beta Cadherin-Associated Protein><Beta-1 Catenin><Bioinformatics><Biological Function><Biological Process><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CUL-2><Cas nuclease technology><Caveolin Proteins><Caveolins><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Signaling><Cell membrane><Cells><Cellular Proliferation><Cellular biology><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Colon><Colon Cancer><Colon Carcinoma><Colorectal Cancer><Complex><Cytoplasmic Membrane><Cytosolic Protein Tyrosine Phosphastase><DNA mutation><Data><Dephosphorylation><Development><Disease><Disorder><E3 Ligase><E3 Ubiquitin Ligase><E3 ubiquitin-protein ligase NEDD4-like><EC-PTP><Endocytosis><Ensure><Epithelium><Equilibrium><GI Stem cell><Genes><Genetic Change><Genetic defect><Genetic mutation><Goals><HG38><Human><Human Figure><Human body><IRES><In Vitro><Internal Ribosome Entry Segment><Internal Ribosome Entry Site><Intestinal><Intestines><Intracellular Communication and Signaling><Investigation><KO mice><Kinase Family Gene><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><LGR5><LGR5 gene><Maintenance><Malignant Cell><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutation><Nedd4-2><Nedd4L><Neural precursor cell expressed developmentally down-regulated gene 4-like><Null Mouse><Oncogenic><Organism><Organoids><PCPTP1><PRO2286><PTP Family Gene><PTP-SL><PTPBR7><PTPRQ><PTPRR><PTPRR gene><PTPase><Pathway interactions><Phosphatases><Phosphohydrolases><Phosphomonoesterases><Phosphoprotein Phosphatase><Phosphoprotein Phosphatase-2C><Phosphoprotein Phosphohydrolase><Phosphoric Monoester Hydrolases><Phosphorylation><Phosphotyrosine Phosphatase><Phosphotyrosyl Protein Phosphatase><Physiologic><Physiological><Physiology><Plasma Membrane><Play><Process><Proliferating><Protein Dephosphorylation><Protein Kinase><Protein Phosphatase C><Protein Phosphatase Gene><Protein Phosphatase-1><Protein Phosphatase-2A><Protein Phosphorylation><Protein Tyrosine Phosphatase><Protein Tyrosine Phosphatase Gene><Protein phosphatase><Proteins><Receptor Protein><Receptor Type PTP Gene><Regulation><Reporter><Ribosome Entry Site><Role><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><System><Technology><Testing><Tissues><Tyrosine Phosphatase><Tyrosyl Phosphoprotein Phosphatase><Ubiquitilation><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><Villus><WNT Signaling Pathway><WNT signaling><attenuate><attenuates><balance><balance function><beta cat><beta catenin><biological signal transduction><bowel><cancer cell><cancer in the colon><cell biology><cellular differentiation><colon cancer patients><colon cancer tumorigenesis><colon tumorigenesis><colorectal cancer patients><colorectal tumorigenesis><developmental><driving><gastrointestinal homeostasis><gastrointestinal stem cell><genome mutation><glycogen synthase a kinase><gut progenitor><gut stem cell><hydroxyalkyl protein kinase><in vivo><inhibitor><insight><intestinal crypt><intestinal epithelium><intestinal homeostasis><intestinal progenitor><intestinal stem cells><knock-down><knockdown><living system><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathway><phosphorylase b kinase kinase><plasmalemma><progenitor cell fate><progenitor cell function><progenitor cell proliferation><progenitor fate><progenitor function><progenitor proliferation><protein tyrosine phosphate phosphohydrolase><receptor><scRNA sequencing><scRNA-seq><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell fate><stem and progenitor cell function><stem and progenitor cell proliferation><stem and progenitor function><stem cell fate><stem cell function><stem cell proliferation><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><three dimensional><tumor growth><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase><β-catenin>
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JEREMY N RICH

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$918,524
FY 2026

Project Title

Targeting Glioblastoma Stem Cells

Grant Number:

5R35CA283998-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

11/30/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Glioblastoma represents one of the most lethal types of cancers. Despite extensive molecular characterization, precision medicine efforts have largely failed for glioblastoma therapy, suggesting that these complex tumors are resilient ecosystems that overcome singular therap...

Research Terms

<Aging><Apical><Autoregulation><Brain><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><Cancer Treatment><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell division><Cells><Combined Modality Therapy><Complex><Cues><Development><Drug Combinations><Drug Targeting><Ecologic Systems><Ecological Systems><Ecosystem><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equilibrium><Generalized Growth><Generations><Glioblastoma><Glioblastoma stem like cancer cell><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Growth><Homeostasis><Human><Immune Evasion><Incidence><Inflammation><Intracellular Communication and Signaling><Invaded><Laboratories><Maintenance><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Metabolic><Metabolic Pathway><Modern Man><Molecular><Multimodal Therapy><Multimodal Treatment><Natural regeneration><Nervous System><Neural Stem Cell><Neurologic Body System><Neurologic Organ System><Nuclear><Nutrient><Organ><Organoids><Patients><Physiological Homeostasis><Proliferating><Regeneration><Regulation><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell like><Testing><Therapeutic><Tissue Growth><Translating><Tumor Cell><Tumor Immunity><Tumor-infiltrating immune cells><aged brain><aging brain><anti-cancer therapy><anti-tumor immunity><antitumor immunity><balance><balance function><biological signal transduction><cancer immunity><cancer microenvironment><cancer progenitor><cancer progenitor cells><cancer progression><cancer stem cell><cancer stem like cell><cancer therapy><cancer type><cancer-directed therapy><combination therapy><combined modality treatment><combined treatment><developmental><empowerment><epigenetically><glioblastoma cancer stem cell><glioblastoma multiforme><glioblastoma progenitor><glioblastoma stem cell><glioblastoma stem like cell><immune cell infiltration of tumors><immune cells infiltrating the tumor><immune cells that infiltrate the tumor><immune evasive><immune microenvironment><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><infiltration of tumors by immune cells><injury to tissue><insight><intratumoral immune cell><intratumoral immune infiltrate><malignancy><malignant progenitor><malignant stem cell><metabolism measurement><metabolomics><metabonomics><mortality><multi-modal therapy><multi-modal treatment><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oncogenic progenitor><oncogenic stem cells><ontogeny><palliation><precision medicine><precision-based medicine><pro-aging><progenitor and neural stem cells><progenitor capacity><progenitor cell like><progenitor cell niche><progenitor like cancer cell><progenitor niche><progenitor-like><progeronic><programs><promote aging><regenerate><regeneration potential><regenerative potential><resilience><resilient><resistance to therapy><resistant to therapy><self-renew><self-renewal><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><spongioblastoma multiforme><stem and progenitor cell niche><stem cell characteristics><stem cell niche><stem like cancer cell><stem-like><stemness><therapeutic resistance><therapeutic target><therapy resistant><tissue injury><tissue progenitor><tissue specific progenitor cells><tissue specific stem cells><tissue stem cells><treatment resistance><tumor><tumor growth><tumor immune cell><tumor immune infiltrate><tumor immune microenvironment><tumor infiltration of immune cells><tumor initiation><tumor microenvironment><tumor progression><tumor-immune system interactions><tumors in the brain><wound response>
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Rachel Lena Rutishauser

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$813,777
FY 2026

Project Title

Targeting HIV-specific T cell differentiation programs to enhance post-treatment control of HIV

Grant Number:

5R01AI170239-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/19/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Nearly 40 million people world-wide are infected with HIV, an infection for which there is no cure. Many strategies that aim to cure HIV focus on harnessing HIV-specific T cells to control the virus that rebounds after antiretroviral therapy (ART) is discontinued because of their abi...

Research Terms

<AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><After Care><After-Treatment><Aftercare><Animal Model><Animal Models and Related Studies><Antigens><Autologous><Bar Codes><Basal Transcription Factor><Basal transcription factor genes><Basic Research><Basic Science><Blood Sample><Blood specimen><Body Tissues><CAR T cell therapy><CAR T cells><CAR T therapy><CAR modified T cells><CAR-T><CAR-Ts><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cancer Control><Cancer Control Science><Cancers><Cell Body><Cells><Chronic><Class I Genes><Clinical><Clinical Trials><Collaborations><Cytometry><Development><Disease><Disorder><Effector Cell><Funding><Future><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><Goals><HIV><HIV Infections><HIV Non-Progressors><HIV Nonprogressors><HIV controller><HIV cure><HIV functional cure><HIV individuals><HIV infected individuals><HIV infected persons><HIV people><HIV positive individuals><HIV positive people><HIV viral infection><HIV virus infection><HIV-1 cure><HIV-1 functional cure><HIV-1 infection><HIV/AIDS cure><Heterograft><Heterologous Transplantation><Human><Human Engineering><Human Immunodeficiency Viruses><In Vitro><Individual><Infection><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Infusion><Infusion procedures><Interruption><Knowledge><LAV-HTLV-III><Literature><Long-term infection><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphadenopathy-Associated Virus><Lymphatic Tissue><Lymphatic nodes><Lymphoid Tissue><MHC Class I><MHC Class I Genes><Macaca><Macaque><Malignant Neoplasms><Malignant Tumor><Mediating><Memory><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><PD-1 blockade><PD1 blockade><PLWH><PWH><Participant><Peptides><Persons><Phenotype><Population><Progenitor Cells><Proliferating><Property><Protocol><Protocols documentation><RNA Expression><Recombinant DNA Technology><Role><SIV><Sampling><Simian Immunodeficiency Viruses><Sorting><Staining method><Stains><Stem Cell like><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell differentiation><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell receptor repertoire sequencing><T cell receptor sequencing><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cells for CAR><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cells><T-Lymphocyte><T-cell therapeutics><T-cell transfer therapy><T8 Cells><T8 Lymphocytes><TCR repertoire sequencing><TCR sequencing><TCR-seq><TCRseq><Teff cell><Testing><Time><Tissue Sample><Tissues><Toxic effect><Toxicities><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><VAC-TX><Vaccine Therapy><Viral><Virus><Virus-HIV><Xenograft><Xenograft procedure><Xenotransplantation><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><analyze gene expression><anti-PD-1 blockade><anti-PD1 blockade><antiretroviral therapy><antiretroviral treatment><barcode><cell killing><chimeric antigen T cell receptor><chimeric antigen receptor><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cell therapy><chimeric antigen receptor T cells><chimeric antigen receptor T therapy><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><chronic infection><curative intervention><curative therapeutic><curative therapy><curative treatments><cytotoxic><developmental><effector T cell><elite controller><exhaust><exhaustion><experience><gene expression analysis><gene expression assay><genetically engineered><high dimensionality><human immunodeficiency virus cure><human immunodeficiency virus infection><immunogen><improved><in vivo><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><infusions><lymph gland><lymph nodes><lymphnodes><malignancy><migration><model of animal><mouse model><multi-modality><multimodality><murine model><neoplasm/cancer><overexpress><overexpression><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><peripheral blood><persistent infection><post treatment><progenitor capacity><progenitor cell like><progenitor-like><progenitor-like cell><programs><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem><stem cell characteristics><stem cells><stem-like><stem-like cell><stemness><therapeutic T-cell platform><therapeutic vaccination><thymus derived lymphocyte><transcription factor><transcriptional profiling><viral rebound><viremic controller><virus rebound><xeno-transplant><xeno-transplantation>
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Wei Hsu

ADA FORSYTH INSTITUTE, INC., Somerville, MA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$762,445
FY 2026

Project Title

Genetic Regulatory Network in Craniofacial Development

Grant Number:

5R01DE015654-18

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/12/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract This competitive renewal continues our efforts to decipher the skeletogenic signaling network underlying craniofacial development and disease. The craniofacial skeleton consists of the viscerocranium and neurocranium, which are subdivided into the calvarium and chondrocranium. During calvar...

Research Terms

<21+ years old><ACVRLK3 Gene><Ablation><Abnormal Cell><Adult><Adult Human><Affect><Anatomic Abnormality><Anatomical Abnormality><Animal Model><Animal Models and Related Studies><Apoptosis><Apoptosis Pathway><Autoregulation><BMP type I receptor><BMPR-I><BMPR1A><BMPR1A gene><Beta Cadherin-Associated Protein><Beta-1 Catenin><Body Tissues><Bone Development><Bone Diseases><Bone Formation><Bone Morphogenetic Protein Receptor, Type IA Gene><Bone Regeneration><CUL-2><Calvaria><Cartilage><Cartilaginous Tissue><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell surface><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Childhood><Chondrocranium><Cleidocranial Dysplasia><Congenital abnormal Synostosis><Cranial Sutures><Craniofacial Abnormalities><Craniosynostosis><DNA Synthesis Factor><DNA mutation><Data><Defect><Deformity><Development><Disease><Disorder><Endothelial Cell Growth Factor><Engraftment><Equilibrium><Etiology><Evaluation><Exhibits><FGF><FGFBR><FGFR1><FGFR1 gene><FLG Gene><FLT2 Gene><FMS-Like Gene><FMS-Like Tyrosine Kinase 2 Gene><Fibroblast Growth Factor><Fibroblast Growth Factor Gene Family><Fibroblast Growth Factor Receptor 1 Gene><Fibroblast Growth Regulatory Factor><Funding><Gene Modified><Gene Transcription><Generalized Growth><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Growth><Health><Homeostasis><Human><Human Development><Human Genetics><Impairment><Implant><Individual><Infant><Injury><Intracellular Communication and Signaling><Investigation><Joint structure of suture of skull><KO mice><Knock-out Mice><Knockout Mice><Link><Maintenance><Marie-Sainton syndrome><Mediating><Mesenchymas><Mesenchyme><Mice><Mice Mammals><Modern Man><Molecular><Morphogenesis><Mouse Strains><Murine><Mus><Mutation><Null Mouse><Osteoblasts><Osteocytes><Osteogenesis><PRO2286><Pathogenesis><Pathway interactions><Patients><Pfeiffer Syndrome><Physiologic Ossification><Physiological Homeostasis><Physiological Ossification><Preventive><Process><Progenitor Cells><Programmed Cell Death><Proliferating><RNA Expression><Regulation><Repression><Role><Scheuthauer-Marie-Sainton syndrome><Signal Transduction><Signal Transduction Systems><Signaling><Site><Skeleton><Skull><Staining method><Stains><Stem Cell like><Surface><Surgical sutures><Sutures><Synostosis><Testing><Therapeutic><Tissue Growth><Tissues><Transcription><WNT Signaling Pathway><WNT signaling><adulthood><autosome><balance><balance function><beta cat><beta catenin><biological signal transduction><bone><bone disorder><bone healing><bone morphogenetic protein receptor type I><bone repair><bone tissue formation><bone wound healing><calvarial><causation><cell type><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><cleidocranial digital dysostosis><cleidocranial dysostosis><craniocleidodysostosis><craniofacial><craniofacial anomalies><craniofacial defects><craniofacial development><craniofacial malformation><craniofacies><cranium><developmental><disease causation><dysostosis cleidocranialis><dysostosis cleidocraniodigitalis><dysostosis cleidocraniopelvina><dysostosis generalisata><dysplasia cleidocranialis><dysplasia cleidofacialis><gene modification><genetic analysis><genetic element><genetically modified><genome mutation><human disease><implantation><in vivo><injured><injuries><injury and repair><insight><intramembranous bone formation><intramembranous ossification><malformation><model of animal><morphogenetic process><multipotency><multipotent><mutational dysostosis><normal ossification><ontogeny><osseous wound healing><ossification><osteoblast cell differentiation><osteoblast differentiation><osteoblast progenitor><osteoblast proliferation><osteoblast stem cell><osteoblastic differentiation><osteodental dysplasia><osteogenic><osteogenic progenitor><osteogenic stem cell><osteoprogenitor><osteoprogenitor cell><pathway><pediatric><pelvicocleidocranial dysostosis><premature><prematurity><progenitor capacity><progenitor cell like><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor cell regeneration><progenitor cell self renewal><progenitor niche><progenitor pool><progenitor population><progenitor regeneration><progenitor self renewal><progenitor-like><reconstruction><regenerate bone><skeletal><skeletal progenitor><skeletal progenitor cell><skeletal stem cell><skeletogenesis><skeletons><social role><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell characteristics><stem cell depletion><stem cell exhaustion><stem cell fatigue><stem cell niche><stem cell pool><stem cell population><stem cell regeneration><stem cell self renewal><stem cells><stem-like><stemness><suture fusion><transcriptome profiling><transcriptomic profiling><β-catenin>
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Nadia Razaq Sutton

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$734,957
FY 2026

Project Title

Probing mechanistic links between endothelial aging and dementia

Grant Number:

1R01AG092663-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The mission of our laboratory is to pursue answers to essential questions in the field vascular aging that will advance our basic understanding and translate into more effective treatments to optimize human vascular healthspan. The central thesis of this project is that endothelial c...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD and related dementia><AD dementia><AD related dementia><ADRD><ANG-2 Gene><ANGPT2><ANGPT2 gene><Achievement><Achievement Attainment><Address><Adult><Adult Human><Age><Aged 65 and Over><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><Ang-2><Ang2><Angiopoietin 2 Gene><Angiopoietin-2><Arteriosclerotic Dementia><Benchmarking><Best Practice Analysis><Biological><Biological Aging><Biological Function><Biological Process><Biology><Blood - brain barrier anatomy><Blood Vessels><Blood-Brain Barrier><Brain Vascular Disorders><Cell Aging><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Line><Cell Senescence><Cell model><CellLine><Cells><Cellular Aging><Cellular Senescence><Cellular model><Cerebrovascular Disease><Cerebrovascular Disorders><Chronology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Computer Models><Computerized Models><Data><Data Set><Dementia><Development><Disease><Disorder><Disturbance in cognition><Dysfunction><Endothelial Cells><Endothelium><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Food and Drug Administration><Foundations><Functional disorder><Future><Genes><Genetic><GrimAge clock><Hannum clock><Hemato-Encephalic Barrier><Horvath clock><Human><Impaired cognition><Impairment><In Vitro><Individual><Intervention><Intracranial Vascular Diseases><Intracranial Vascular Disorders><Laboratories><Libraries><Link><Methodology><Mission><Mitochondria><Modeling><Modern Man><Outcome><Oxidative Stress><PBMC><Pathology><Peripheral Blood Mononuclear Cell><PhenoAge clocks><Physiopathology><Primary Senile Degenerative Dementia><Proteins><Proteomics><Regenerative Medicine><Replicative Senescence><Research><Source><Strains Cell Lines><Study models><Surface><Technology><Testing><Therapeutic><Translating><USFDA><United States Food and Drug Administration><Validation><Vascular Dementia><Vascular Diseases><Vascular Disorder><Vascular Endothelial Cell><Vascular aging><Work><above age 65><adult youth><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age correlated><age dependent><age linked><age of 65 years onward><age related><age related pathways><age specific><aged 65 and greater><aged 65+><aged brain><aged ≥65><ages><aging associated mechanism><aging brain><aging mechanism><aging pathway><aging process><aging related mechanism><aging related pathways><angiogenesis><benchmark><biologic><biological age><biological development><biological mechanism of age><biological pathways of age><biological process of age><biosignature><blood vessel disorder><bloodbrain barrier><brain vascular disease><brain vascular dysfunction><cardiac disease induced cognitive impairment><cell type><cellular differentiation><cerebral vascular disease><cerebral vascular dysfunction><cerebrovascular contribution to cognitive impairment and dementia><cerebrovascular contributions to dementia><cerebrovascular dysfunction><clinical center><cognitive dysfunction><cognitive loss><computational modeling><computational models><computer based models><computer based prediction><computerized modeling><cultured cell line><data pipeline><developmental><differentiation of pluripotent stem cells><effective therapy><effective treatment><endothelial dysfunction><epigenetic age clocks><epigenetic clock><epigenetic molecular clocks><epigenetically><experiment><experimental research><experimental study><experiments><hallmarks of aging><healthspan><healthy life span><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human old age (65+)><iPS><iPSC><iPSCs><in vitro Model><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><internet portal><intracranial vascular dysfunction><mechanism regulating aging><mechanisms involved in aging><methylation clock><mitochondrial><multi-scale computational modeling><multi-scale mathematical modeling><multi-scale modeling><multiomics><multiple omics><multiscale computational modeling><multiscale mathematical modeling><multiscale modeling><novel><older adult><older adulthood><on-line portal><online portal><over 65 years><panomics><pathophysiology><pathway involved in aging><pillars of aging><pluripotent stem cell differentiation><predictive modeling><primary degenerative dementia><progenitor biology><progenitor cell biology><replicative aging><response><senescence><senescent><senile dementia of the Alzheimer type><stem and progenitor biology><stem cell biology><synthetic biology><transcriptomics><validations><vascular><vascular cognitive impairment and dementia><vascular contribution to impairment or dementia><vascular contributions in dementia><vascular contributions to cognition/dementia><vascular contributions to cognitive decline and dementia><vascular contributions to cognitive impairment and dementia><vascular contributions to dementia><vascular dysfunction><vascular related dementia><vasculature aging><vasculopathy><web portal><web-based portal><young adult><young adult age><young adulthood><≥65 years>
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Arnold Han

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$715,501
FY 2026

Project Title

T helper cells and stem cells in colon homeostasis and tumor initiation

Grant Number:

5R01DK142438-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Intestinal neoplasia originates in stem cells that render their function niche-independent, or non-stem cells that acquire stem-cell traits. We recently discovered a novel upper crypt intestinal stem cell (ISC) population marked by Fgfbp1 in the small intestine. Our findings define a...

Research Terms

<3-D><3-Dimensional><3D><Autoregulation><Body Tissues><Cancer Induction><Cell Body><Cell Differentiation><Cell Differentiation process><Cells><Chronic><Colon><Colon Neoplasms><Colon Tumor><Colonic Mass><Colonic Neoplasms><Colonic Tumor><Colorectal Neoplasms><Colorectal Tumors><Columnar Cell><DNA mutation><Data><Diagnostic><Epithelium><Event><FGFBP><FGFBP1><FGFBP1 gene><Fibroblast Growth Factor Binding Protein 1><GI Stem cell><Genetic><Genetic Change><Genetic defect><Genetic mutation><HBP17><HG38><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Histologic><Histologically><Homeostasis><Human><Immune><Immune system><Immunes><Immunity><Inducer Cells><Inducer T-Lymphocytes><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal Neoplasia><Intestinal Neoplasms><Intestinal Tumor><Intestines Neoplasms><LGR5><LGR5 gene><Large Bowel Tumor><Large Intestine Neoplasm><Large Intestine Tumor><Lineage Tracing><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Mutation><Natural regeneration><Neoplasms><Neoplastic Cell Transformation><Oncogenesis><Organoids><Pathogenesis><Pathway interactions><Physiological Homeostasis><Play><Population><Prevention><Process><Progenitor Cells><Prospective Studies><Publishing><Regeneration><Role><Small Intestines><Source><Stem Cell Research><Supporting Cell><T-Cells><T-Lymphocyte><Therapeutic><Tissues><Tumor Cell><Tumor Subtype><adenoma><base><bases><cancer progression><carcinogenesis><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell regeneration><cell type><cellular differentiation><cellular lineage mapping><cellular lineage tracking><cellular regeneration><colon cancer tumorigenesis><colon neoplasia><colon tumorigenesis><colonic crypt><colorectal neoplasia><colorectal tumorigenesis><cytokine><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><epithelium regeneration><gastrointestinal stem cell><genome mutation><gut progenitor><gut stem cell><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><interest><intestinal autoinflammation><intestinal crypt><intestinal epithelium><intestinal progenitor><intestinal stem cells><large bowel neoplasm><molecular pathology><mouse genetics><mouse model><multipotent cell><murine model><neoplasia><neoplasm progression><neoplastic cell><neoplastic growth><neoplastic progression><neoplastic transformation><novel><pathway><progenitor biology><progenitor cell biology><progenitor cell function><progenitor cell model><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor cell regeneration><progenitor cell self renewal><progenitor function><progenitor model><progenitor niche><progenitor pool><progenitor population><progenitor regeneration><progenitor self renewal><prospective research study><prospective survey><regenerate><regenerate epithelium><self-renew><self-renewal><small bowel><social role><stem and progenitor biology><stem and progenitor cell function><stem and progenitor cell model><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor function><stem cell based model><stem cell biology><stem cell derived model><stem cell function><stem cell model><stem cell niche><stem cell pool><stem cell population><stem cell regeneration><stem cell self renewal><stem cell study><stem cells><three dimensional><thymus derived lymphocyte><tool><trait><translation strategy><translational approach><translational strategy><tumor initiation><tumor progression><tumorigenesis>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kelley Yan

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$715,501
FY 2026

Project Title

T helper cells and stem cells in colon homeostasis and tumor initiation

Grant Number:

5R01DK142438-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Intestinal neoplasia originates in stem cells that render their function niche-independent, or non-stem cells that acquire stem-cell traits. We recently discovered a novel upper crypt intestinal stem cell (ISC) population marked by Fgfbp1 in the small intestine. Our findings define a...

Research Terms

<3-D><3-Dimensional><3D><Autoregulation><Body Tissues><Cancer Induction><Cell Body><Cell Differentiation><Cell Differentiation process><Cells><Chronic><Colon><Colon Neoplasms><Colon Tumor><Colonic Mass><Colonic Neoplasms><Colonic Tumor><Colorectal Neoplasms><Colorectal Tumors><Columnar Cell><DNA mutation><Data><Diagnostic><Epithelium><Event><FGFBP><FGFBP1><FGFBP1 gene><Fibroblast Growth Factor Binding Protein 1><GI Stem cell><Genetic><Genetic Change><Genetic defect><Genetic mutation><HBP17><HG38><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Histologic><Histologically><Homeostasis><Human><Immune><Immune system><Immunes><Immunity><Inducer Cells><Inducer T-Lymphocytes><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal Neoplasia><Intestinal Neoplasms><Intestinal Tumor><Intestines Neoplasms><LGR5><LGR5 gene><Large Bowel Tumor><Large Intestine Neoplasm><Large Intestine Tumor><Lineage Tracing><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Mutation><Natural regeneration><Neoplasms><Neoplastic Cell Transformation><Oncogenesis><Organoids><Pathogenesis><Pathway interactions><Physiological Homeostasis><Play><Population><Prevention><Process><Progenitor Cells><Prospective Studies><Publishing><Regeneration><Role><Small Intestines><Source><Stem Cell Research><Supporting Cell><T-Cells><T-Lymphocyte><Therapeutic><Tissues><Tumor Cell><Tumor Subtype><adenoma><base><bases><cancer progression><carcinogenesis><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell regeneration><cell type><cellular differentiation><cellular lineage mapping><cellular lineage tracking><cellular regeneration><colon cancer tumorigenesis><colon neoplasia><colon tumorigenesis><colonic crypt><colorectal neoplasia><colorectal tumorigenesis><cytokine><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><epithelium regeneration><gastrointestinal stem cell><genome mutation><gut progenitor><gut stem cell><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><interest><intestinal autoinflammation><intestinal crypt><intestinal epithelium><intestinal progenitor><intestinal stem cells><large bowel neoplasm><molecular pathology><mouse genetics><mouse model><multipotent cell><murine model><neoplasia><neoplasm progression><neoplastic cell><neoplastic growth><neoplastic progression><neoplastic transformation><novel><pathway><progenitor biology><progenitor cell biology><progenitor cell function><progenitor cell model><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor cell regeneration><progenitor cell self renewal><progenitor function><progenitor model><progenitor niche><progenitor pool><progenitor population><progenitor regeneration><progenitor self renewal><prospective research study><prospective survey><regenerate><regenerate epithelium><self-renew><self-renewal><small bowel><social role><stem and progenitor biology><stem and progenitor cell function><stem and progenitor cell model><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor function><stem cell based model><stem cell biology><stem cell derived model><stem cell function><stem cell model><stem cell niche><stem cell pool><stem cell population><stem cell regeneration><stem cell self renewal><stem cell study><stem cells><three dimensional><thymus derived lymphocyte><tool><trait><translation strategy><translational approach><translational strategy><tumor initiation><tumor progression><tumorigenesis>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Irina V Balyasnikova

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$666,186
FY 2026

Project Title

Spatial and Temporal Tracking of Neural Stem Cells Migration to Brain Metastases of Breast Cancer using High Resolution Imaging

Grant Number:

5R01CA297777-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Patients diagnosed with breast cancer brain metastases (BM) have a poor prognosis, and their therapeutic options are minimal. Surgical intervention is limited to a single lesion, whereas most women present with multiple metastases, and most chemotherapeutic drugs are not effective d...

Research Terms

<Animal Model><Animal Models and Related Studies><Antibodies><Behavior><Blood - brain barrier anatomy><Blood-Brain Barrier><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Metastasis><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><Breast Cancer><Breast Metastasis><CNS Nervous System><Cancers><Cell Body><Cell Communication><Cell Interaction><Cell secretion><Cell-to-Cell Interaction><Cells><Cellular Secretion><Central Nervous System><Clinical Trials><Complex><Contrast Agent><Contrast Drugs><Contrast Media><Cranial Irradiation><Data><Development><Diagnosis><ERBB2><ERBB2 gene><Encephalon><Encephalon Diseases><Engraftment><Ensure><Environment><Experimental Animal Model><Experimental Models><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioblastoma><Glioma><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><HER -2><HER-2><HER2><HER2 Genes><HER2/neu><Hemato-Encephalic Barrier><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><In Vitro><Incidence><Injections><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Invaded><Investigators><Kinetics><Knowledge><Label><Laboratories><Lesion><Ligands><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance><Magnetic Resonance Imaging><Malignant Breast Neoplasm><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Brain><Metastatic Tumor><Metastatic Tumor to the Brain><Metastatic malignant neoplasm to brain><Methodology><Methods><Mice><Mice Mammals><Microscope><Modeling><Monitor><Multimodal Imaging><Murine><Mus><NEU Oncogene><NEU protein><NMR Imaging><NMR Tomography><Neoplasm Metastasis><Neural Development><Neural Stem Cell><Neuraxis><Neuroglial Neoplasm><Neuroglial Tumor><Nuclear Magnetic Resonance Imaging><Oncogene ErbB2><Operative Procedures><Operative Surgical Procedures><Organ><PET><PET Scan><PET imaging><PETSCAN><PETT><Patients><Permeability><Photons><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Pre-Clinical Model><Preclinical Models><Preclinical data><Progenitor Cells><Prognosis><Property><Protocol><Protocols documentation><Rad.-PET><Radiation therapy><Radiopaque Media><Radiotherapeutics><Radiotherapy><Receptor Protein><Recommendation><Research Personnel><Researchers><Resolution><Route><SPECT><SPECT imaging><Secondary Neoplasm><Secondary Tumor><Single-Photon Emission-Computed Radionuclide Tomography><Solid><Solid Neoplasm><Solid Tumor><Stem Cell like><Surgical><Surgical Interventions><Surgical Procedure><System><TKR1><Therapeutic><Therapeutic Effect><Therapeutic antibodies><Tissues><Translations><Tropism><Validation><Woman><Work><Zeugmatography><bloodbrain barrier><brain based><brain irradiation><brain micrometastasis><brain parenchyma><brain radiation><breast cancer metastasis><c-erbB-2><c-erbB-2 Genes><c-erbB-2 Proto-Oncogenes><cancer cell><cancer metastasis><cell behavior><cellular behavior><chemotherapeutic agent><chemotherapeutic compounds><chemotherapeutic drugs><chemotherapeutic medications><chemotherapy><compound eye><cranial radiation><design><designing><developmental><erbB-2 Genes><glial-derived tumor><glioblastoma multiforme><herstatin><high resolution imaging><image-based method><imaging><imaging agent><imaging approach><imaging based approach><imaging method><imaging modality><imaging platform><immunogenicity><improved><in vivo><instrumentation><interest><malignancy><malignant breast tumor><migration><model of animal><multi-modal imaging><multi-modality imaging><multimodality imaging><nano particle><nano-sized particle><nanoparticle><nanosized particle><neoplasm/cancer><nerve stem cell><neu Genes><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopment><neurogenic progenitors><neurogenic stem cell><neuroglia neoplasm><neuroglia tumor><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><non-invasive imaging><noninvasive imaging><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><pre-clinical study><preclinical><preclinical findings><preclinical information><preclinical study><progenitor and neural stem cells><progenitor biology><progenitor capacity><progenitor cell based therapy><progenitor cell biology><progenitor cell fate><progenitor cell like><progenitor cell migration><progenitor cell therapy><progenitor cell treatment><progenitor fate><progenitor migration><progenitor therapy><progenitor treatment><progenitor-like><radiation treatment><receptor><resolutions><side effect><single photon emission computed tomography><site targeted delivery><spatial and temporal><spatial temporal><spatial temporal imaging><spatial temporal mapping><spatiotemporal><spatiotemporal imaging><spatiotemporal mapping><spongioblastoma multiforme><stem and progenitor biology><stem and progenitor cell fate><stem and progenitor cell therapy><stem cell based therapy><stem cell biology><stem cell characteristics><stem cell fate><stem cell mediated therapy><stem cell migration><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><stem-like><stemness><surgery><targeted delivery><therapeutic evaluation><therapeutic testing><translation><treatment with radiation><tumor><tumor cell metastasis><tumors in the brain><uptake><validations>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Chin-Tu Chen

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$666,186
FY 2026

Project Title

Spatial and Temporal Tracking of Neural Stem Cells Migration to Brain Metastases of Breast Cancer using High Resolution Imaging

Grant Number:

5R01CA297777-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Patients diagnosed with breast cancer brain metastases (BM) have a poor prognosis, and their therapeutic options are minimal. Surgical intervention is limited to a single lesion, whereas most women present with multiple metastases, and most chemotherapeutic drugs are not effective d...

Research Terms

<Animal Model><Animal Models and Related Studies><Antibodies><Behavior><Blood - brain barrier anatomy><Blood-Brain Barrier><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Metastasis><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><Breast Cancer><Breast Metastasis><CNS Nervous System><Cancers><Cell Body><Cell Communication><Cell Interaction><Cell secretion><Cell-to-Cell Interaction><Cells><Cellular Secretion><Central Nervous System><Clinical Trials><Complex><Contrast Agent><Contrast Drugs><Contrast Media><Cranial Irradiation><Data><Development><Diagnosis><ERBB2><ERBB2 gene><Encephalon><Encephalon Diseases><Engraftment><Ensure><Environment><Experimental Animal Model><Experimental Models><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioblastoma><Glioma><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><HER -2><HER-2><HER2><HER2 Genes><HER2/neu><Hemato-Encephalic Barrier><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><In Vitro><Incidence><Injections><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Invaded><Investigators><Kinetics><Knowledge><Label><Laboratories><Lesion><Ligands><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance><Magnetic Resonance Imaging><Malignant Breast Neoplasm><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Brain><Metastatic Tumor><Metastatic Tumor to the Brain><Metastatic malignant neoplasm to brain><Methodology><Methods><Mice><Mice Mammals><Microscope><Modeling><Monitor><Multimodal Imaging><Murine><Mus><NEU Oncogene><NEU protein><NMR Imaging><NMR Tomography><Neoplasm Metastasis><Neural Development><Neural Stem Cell><Neuraxis><Neuroglial Neoplasm><Neuroglial Tumor><Nuclear Magnetic Resonance Imaging><Oncogene ErbB2><Operative Procedures><Operative Surgical Procedures><Organ><PET><PET Scan><PET imaging><PETSCAN><PETT><Patients><Permeability><Photons><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Pre-Clinical Model><Preclinical Models><Preclinical data><Progenitor Cells><Prognosis><Property><Protocol><Protocols documentation><Rad.-PET><Radiation therapy><Radiopaque Media><Radiotherapeutics><Radiotherapy><Receptor Protein><Recommendation><Research Personnel><Researchers><Resolution><Route><SPECT><SPECT imaging><Secondary Neoplasm><Secondary Tumor><Single-Photon Emission-Computed Radionuclide Tomography><Solid><Solid Neoplasm><Solid Tumor><Stem Cell like><Surgical><Surgical Interventions><Surgical Procedure><System><TKR1><Therapeutic><Therapeutic Effect><Therapeutic antibodies><Tissues><Translations><Tropism><Validation><Woman><Work><Zeugmatography><bloodbrain barrier><brain based><brain irradiation><brain micrometastasis><brain parenchyma><brain radiation><breast cancer metastasis><c-erbB-2><c-erbB-2 Genes><c-erbB-2 Proto-Oncogenes><cancer cell><cancer metastasis><cell behavior><cellular behavior><chemotherapeutic agent><chemotherapeutic compounds><chemotherapeutic drugs><chemotherapeutic medications><chemotherapy><compound eye><cranial radiation><design><designing><developmental><erbB-2 Genes><glial-derived tumor><glioblastoma multiforme><herstatin><high resolution imaging><image-based method><imaging><imaging agent><imaging approach><imaging based approach><imaging method><imaging modality><imaging platform><immunogenicity><improved><in vivo><instrumentation><interest><malignancy><malignant breast tumor><migration><model of animal><multi-modal imaging><multi-modality imaging><multimodality imaging><nano particle><nano-sized particle><nanoparticle><nanosized particle><neoplasm/cancer><nerve stem cell><neu Genes><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopment><neurogenic progenitors><neurogenic stem cell><neuroglia neoplasm><neuroglia tumor><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><non-invasive imaging><noninvasive imaging><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><pre-clinical study><preclinical><preclinical findings><preclinical information><preclinical study><progenitor and neural stem cells><progenitor biology><progenitor capacity><progenitor cell based therapy><progenitor cell biology><progenitor cell fate><progenitor cell like><progenitor cell migration><progenitor cell therapy><progenitor cell treatment><progenitor fate><progenitor migration><progenitor therapy><progenitor treatment><progenitor-like><radiation treatment><receptor><resolutions><side effect><single photon emission computed tomography><site targeted delivery><spatial and temporal><spatial temporal><spatial temporal imaging><spatial temporal mapping><spatiotemporal><spatiotemporal imaging><spatiotemporal mapping><spongioblastoma multiforme><stem and progenitor biology><stem and progenitor cell fate><stem and progenitor cell therapy><stem cell based therapy><stem cell biology><stem cell characteristics><stem cell fate><stem cell mediated therapy><stem cell migration><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><stem-like><stemness><surgery><targeted delivery><therapeutic evaluation><therapeutic testing><translation><treatment with radiation><tumor><tumor cell metastasis><tumors in the brain><uptake><validations>
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Le Cong

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$618,688
FY 2026

Project Title

Combinatorial Perturbation with Multi-Omics Readout to Dissect Etiology of Alzheimer's Disease Using Stem Cell and In Vivo Models

Grant Number:

5R01AG091819-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Combinatorial Perturbation with Multi-Omics Readout to Dissect Etiology of Alzheimer's Disease Using Stem Cell and In Vivo Models Abstract Alzheimer's disease (AD) is a prevalent age-related neurodegenerative disorder. While early-onset AD is driven by well-characterized genes, the mechanistic links...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AAV delivered><AAV delivery><AAV-based delivery><AAV-based viral delivery><AAV-mediated delivery><ABCA1><ABCA1 protein><AD dementia><AD model><AD risk><AD risk factor><AD therapy><AD treatment><APOE><ATP binding cassette transporter 1><Adeno-associated-virus-based delivery><Affect><Age><Aged 65 and Over><Aging><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's diagnosis><Alzheimer's disease diagnosis><Alzheimer's disease model><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's therapy><Alzheimers Dementia><Animal Model><Animal Models and Related Studies><Apo-E><ApoE protein><Apolipoprotein E><Apoptosis-Related Cysteine Protease Caspase 7><Apoptosis-Related Cysteine Protease Gene Caspase 7><Apoptotic Protease MCH-3 Gene><Apoptotic Protease Mch-3><Automobile Driving><Bacteriophages><Brain><Brain Nervous System><CASP7><CASP7 gene><CASP7 protein><CMH-1><CRISPR approach><CRISPR based approach><CRISPR library><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based library><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 library><CRISPR/Cas9 technology><Cas nuclease technology><Caspase-7 Gene><Causality><Cell model><Cellular model><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats library><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complex><Computational Biology><DNA Alteration><DNA Sequence Alteration><Data><Data Set><Degenerative Neurologic Disorders><Development><Diagnosis><Diathesis><Disease><Disease susceptibility><Disorder><Disturbance in cognition><EOAD><Early Onset Alzheimer Disease><Encephalon><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Family><Gene variant><Genes><Genetic><Genetic Alteration><Genetic Diseases><Genetic study><Genome><HDLDT1><Heritability><HuBMAP><Human><Human BioMolecular Atlas Program><Human Genetics><ICE-LAP3><ICE-LAP3 Gene><ICE-Like Apoptotic Protease 3><ICE-Like Apoptotic Protease 3 Gene><Impaired cognition><Individual><Investigators><Label><Late Onset Alzheimer Disease><Late onset AD><Light><Link><MCH3><Memory Loss><Modeling><Modern Man><Mouse Strains><Multiomic Data><NIH><National Institutes of Health><Nerve Degeneration><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Older Population><Onset of illness><Pathogenesis><Patients><Phages><Phosphoproteins><Photoradiation><Primary Senile Degenerative Dementia><Progenitor Cells><Proteins><Research Personnel><Research Resources><Researchers><Resources><Risk Factors><Risk-associated variant><Sequence Alteration><Series><Shapes><Societies><Symptoms><System><TREM2><TREM2 gene><Technology><Testing><Time><Transgenic Organisms><Triggering Receptor Expressed in Myeloid Cells 2><Triggering Receptor Expressed on Myeloid Cells 2><United States National Institutes of Health><Work><above age 65><adeno-associated viral vector delivery><adeno-associated virus delivery><adeno-associated virus mediated delivery><adenovirus mediated delivery><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age of 65 years onward><age related neurodegeneration><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><aged 65 and greater><aged 65+><aged ≥65><ages><aging associated disease><aging associated disorders><aging associated neurodegeneration><aging associated neurodegenerative disease><aging process><aging related disease><aging related disorders><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><allelic variant><alzheimer model><alzheimer risk><bacterial virus><caspase-7><causation><cell type><cholesterol-efflux regulatory protein><cognitive dysfunction><cognitive loss><combinatorial><computer biology><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><delivered with AAV><delivery vector><delivery vehicle><delivery with AAV><developmental><disability><disease associated with aging><disease causation><disease of aging><disease onset><disorder of aging><disorder onset><disorders associated with aging><disorders related to aging><driving><early onset><early onset AD><early onset Alzheimer's><epigenetically><functional genomics><genetic condition><genetic disorder><genetic variant><genomic alteration><genomic variant><global gene expression><global transcription profile><hallmarks of aging><human old age (65+)><human progenitor><human stem cells><in vivo><in vivo Model><innovate><innovation><innovative><insight><late onset alzheimer><liability to disease><memory decline><model of animal><multiomics><multiple omic data><multiple omics><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal degeneration><novel><older adult><older adulthood><older groups><older individuals><older person><over 65 years><panomics><pillars of aging><primary degenerative dementia><prime editing><progenitor cell model><progenitor model><protective allele><protective variant><risk allele><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk gene><risk genotype><risk loci><risk locus><risk of developing Alzheimer's><risk variant><senile dementia of the Alzheimer type><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stem cells><synergism><tool><transcriptome><transgenic><vector><≥65 years>
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XANDRA OWENS BREAKEFIELD

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$597,585
FY 2026

Project Title

Immuno-Cell Therapy for Brain Tumors

Grant Number:

5R01NS122163-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Glioblastoma (GBM) comprises >50% of all brain tumors in adults and is the most malignant form with a 5-year patient survival rate of 3.3%. Standard-of-care treatment involves maximal surgical resection followed by radiation and chemotherapy (temozolomide); however, as the poor survival rat...

Research Terms

<21+ years old><Abscission><Adult><Adult Human><Affect><Antibodies><Autograft><Autologous Transplantation><Autotransplant><Axon><Brain><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><CNS Nervous System><CNS Tumor><CNS neoplasm><Cell Body><Cell Communication><Cell Growth in Number><Cell Interaction><Cell Locomotion><Cell Migration><Cell Movement><Cell Multiplication><Cell Proliferation><Cell Therapy><Cell secretion><Cell-to-Cell Interaction><Cells><Cellular Migration><Cellular Motility><Cellular Proliferation><Cellular Secretion><Central Nervous System><Central Nervous System Neoplasms><Central Nervous System Tumors><Cessation of life><Chemotactic Cytokines><Chemotherapy and Radiation><Chemotherapy and/or radiation><Clinic><Cues><Data><Death><Development><Disease Progression><Encephalon><Excision><Extirpation><Generalized Growth><Glia><Glial Cell Tumors><Glial Cells><Glial Neoplasm><Glial Tumor><Glioblastoma><Glioblastoma stem like cancer cell><Glioma><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Growth><Homing><Homologous Chemotactic Cytokines><Human><Immune><Immune Cell Activation><Immune response><Immunes><Immunomodulation><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Infiltration><Inflammatory><Injury><Innate Immunity><Intercrines><Intranasal Administration><Intranasal Drug Administration><Kolliker's reticulum><Life><Maintenance><Malignant><Malignant - descriptor><Mesenchymal><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Native Immunity><Natural Immunity><Nerve Regeneration><Neural Stem Cell><Neuraxis><Neurites><Neuro-regeneration><Neuroglia><Neuroglial Cells><Neuroglial Neoplasm><Neuroglial Tumor><Neuroregeneration><Non-Specific Immunity><Non-neuronal cell><Nonneuronal cell><Nonspecific Immunity><Normal Cell><Olfactory Epithelium><Olfactory Pathways><Olfactory Receptor Neurons><Olfactory system><Operative Procedures><Operative Surgical Procedures><PD 1><PD-1><PD1><PDX model><Pathway interactions><Patient derived xenograft><Patients><Peripheral Nervous System><Phagocytes><Phagocytic Cell><Physiologic><Physiological><Predisposition><Process><Proliferating><Property><Radiation><Recurrent Neoplasm><Recurrent tumor><Removal><Resistance><Role><Route><SIS cytokines><Shapes><Stem Cell like><Stream><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Survival Rate><Susceptibility><T-Cells><T-Lymphocyte><Temodal><Temodar><Therapeutic><Therapeutic Effect><Time><Tissue Growth><Tropism><Tumor Cell><Tumor Immunity><adaptive immune response><adaptive immunity><adulthood><amebocyte><anti-tumor immunity><antitumor immunity><arm><autologous graft><autotransplantation><biological sex as a modifier><cancer immunity><cell based intervention><cell killing><cell mediated intervention><cell mediated therapies><cell motility><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chemo/radiation therapy><chemoattractant cytokine><chemokine><chemotherapy and radiotherapy><clinical translation><clinically translatable><conventional therapy><conventional treatment><cytokine><cytotoxic><determine efficacy><developmental><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><exhaust><glial-derived tumor><glioblastoma cancer stem cell><glioblastoma multiforme><glioblastoma progenitor><glioblastoma stem cell><glioblastoma stem like cell><glioma cancer stem cell><glioma cancer stem like cell><glioma progenitor><glioma stem cells><glioma stem like cell><host response><immune activation><immune modulation><immune regulation><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><in vivo><injuries><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><methazolastone><migration><neoplasm recurrence><neoplastic cell><nerve cement><nerve stem cell><nervous system regeneration><neural><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural regeneration><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuroglia neoplasm><neuroglia tumor><neurological pathology><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><neuroprotection><neuroprotective><neuroregenerative><olfactory bulb><olfactory circuitry><olfactory circuits><ontogeny><pathway><patient derived xenograft model><prevent><preventing><progenitor and neural stem cells><progenitor capacity><progenitor cell based therapy><progenitor cell differentiation><progenitor cell like><progenitor cell therapy><progenitor cell treatment><progenitor differentiation><progenitor therapy><progenitor treatment><progenitor-like><progenitor-like cell><programmed cell death 1><programmed cell death protein 1><programmed death 1><radiation or chemotherapy><regenerated nerve><resection><resistant><sex as a biological factor><sex as a biological measure><sex as a biological risk factor><sex as a biological variable><sex as a biological variance><sex as a biologically significant variable><sex as a fundamental variable><sle2><social role><spongioblastoma multiforme><standard of care><stem and progenitor cell therapy><stem and progenitor differentiation><stem cell based therapy><stem cell characteristics><stem cell differentiation><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem-like><stem-like cell><stemness><surgery><systemic lupus erythematosus susceptibility 2><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><temozolomide><therapeutic transgene><thymus derived lymphocyte><tumor><tumor growth><tumor of the central nervous system><tumors in the brain><tumors in the central nervous system>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Emery H. Bresnick

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$577,708
FY 2026

Project Title

Hematopoietic Regulation via GATA Switches

Grant Number:

5R01DK068634-21

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2006

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Our program to forge principles for how GATA factors act through chromatin to control development, function and dysfunction of the hematopoietic system discovered conserved Gata2 enhancers (+9.5 and -77) that ensure normal hematopoiesis. There were no reports of enhancers essential for ste...

Research Terms

<AML - Acute Myeloid Leukemia><AML/MDS><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Alleles><Allelomorphs><Assay><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Benign><Bioassay><Biological><Biological Assay><Blood Cells><Blood Diseases><Blood Precursor Cell><Blood monocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chromatin><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Chronic Granulocytic Leukemia><Chronic Myelocytic Leukemia><Chronic Myelogenous Leukemia><Chronic Myeloid Leukemia><Clinical><Clinical genetics><Code><Coding System><Consult><DNA Binding><DNA Binding Interaction><DNA bound><DNA mutation><Defect><Development><Dysfunction><Dysmyelopoietic Syndromes><ERYF1><Emberger syndrome><Endowment><Enhancers><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Erythropoiesis><Fetal Liver><Fingers><Foundations><Functional disorder><GATA Binding Protein 1><GATA-1><GATA1><GATA1 gene><GATA1 protein><GATA1 transcription factor><GATA2 deficiency><GATA2 haploinsufficiency><GF-1 protein><Gene variant><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Screening><Genetic Variation><Genetic defect><Genetic mutation><Genome><Genotype><Germ Lines><Germ-Line Mutation><Granulopoiesis><Hematologic Body System><Hematologic Diseases><Hematologic Organ System><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic><Hematopoietic Body System><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic System><Hematopoietic stem cells><Hereditary Mutation><Heterozygote><Human><Human Activities><Human Genetics><Immune><Immunes><Immunodeficiency Disorder><Immunodeficiency Syndrome><Immunologic Deficiency Syndromes><Immunological Deficiency Syndromes><Impairment><International><Intracellular Communication and Signaling><Life><Liver Stem Cell><Marrow monocyte><Mediating><Medical Genetics><Medical center><Mice><Mice Mammals><Modeling><Modern Man><Molecular><MonoMAC><Murine><Mus><Mutation><Myelodysplastic Disease><Myelodysplastic Syndromes><Myeloid Disease><Myeloid Malignancy><Myeloid Neoplasm><Myeloid Tumor><Myeloproliferative Disorders><Myeloproliferative Tumors><Myeloproliferative disease><NF-E1 erythroid-specific transcription factor><NFE1 protein><Nucleotides><Outcome><Pathogenesis><Pathogenicity><Pathologic><Patients><Peripheral Blood Cell><Phenotype><Physicians><Physiologic><Physiological><Physiopathology><Polyvinyl Alcohol><Preventative strategy><Prevention strategy><Preventive strategy><Process><Progenitor Cells><Proteome><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Regimen><Regulation><Reporting><Research><Signal Transduction><Signal Transduction Systems><Signaling><Site><Smoldering Leukemia><Somatic Mutation><Syndrome><System><Testing><Therapeutic><Transcription Factor GATA1><Transcription Factor Proto-Oncogene><Transcription factor genes><Variant><Variation><Work><acute granulocytic leukemia><acute granulocytic leukemia cell><acute myeloblastic leukemia cell><acute myelocytic leukemia cell><acute myelogenous leukemia cell><acute myeloid leukemia><acute myeloid leukemia cell><acute myeloid leukemia/myelodysplastic syndrome><acute nonlymphocytic leukemia cell><allelic variant><biologic><biological signal transduction><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood-forming stem cell><chromatin modifier><clinical center><clinical practice><consults><developmental><diagnostic approach><diagnostic strategy><disease causing variant><disease-causing allele><disease-causing mutation><driving><epigenetic gene silencing><epigenetic silencing><epigenetically><erythroid development><extracellular><forging><gain of function><genetic variant><genome mutation><genomic variant><germ-line defect><germline variant><global gene expression><global transcription profile><globin transcription factor 1><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><hepatic progenitor><hepatic stem cell><heterozygosity><homopolymer Ethenol><hypoimmunity><immune deficiency><immune deficiency disorder><immunodeficiency><in vivo><innovate><innovation><innovative><liver progenitor><monocyte><mouse model><multiomics><multiple omics><murine model><mutant><myelodysplasia><myeloproliferative neoplasm><novel><nuclear factor-erythroid 1><panomics><pathogenic allele><pathogenic variant><pathophysiology><progenitor><progenitor cell expansion><progenitor cell fate><progenitor cell function><progenitor cell model><progenitor expansion><progenitor fate><progenitor function><progenitor model><programs><response><somatic variant><stem and progenitor cell expansion><stem and progenitor cell fate><stem and progenitor cell function><stem and progenitor cell model><stem and progenitor function><stem cell based model><stem cell derived model><stem cell expansion><stem cell fate><stem cell function><stem cell model><stem cells><transcription factor><transcription factor NFE-1><transcriptome><transplant therapy><transplant treatment><transplantation therapy><transplantation treatment>
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Miller Huang

CHILDREN'S HOSPITAL OF LOS ANGELES, LOS ANGELES, CA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$558,719
FY 2026

Project Title

Define the role of chromosome 17q gain in neuroblastoma malignancy

Grant Number:

5R01CA289964-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Neuroblastoma (NB) is the most common pediatric extracranial solid tumor. The cell of origin for NB is believed to be sympathoadrenal cells that are derived from trunk neural crest cells. Recurring mutations are exceedingly rare in NB, while chromosome copy number changes ar...

Research Terms

<17q><21+ years old><ALK protein><ATAC sequencing><ATAC-seq><ATACseq><Acceleration><Adrenergic Agents><Adrenergic Drugs><Adrenergics><Adult><Adult Human><Affect><Anaplastic Lymphoma Kinase Ki-1><Assay for Transposase-Accessible Chromatin using sequencing><Biology><Brachydanio rerio><CD246 Antigen><CRISPR interference><CRISPR-dCas9-mediated repression><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Cancer Genes><Cancer-Promoting Gene><Cancers><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Line><CellLine><Cells><Cellular Expansion><Cellular Growth><Chemoresistance><Childhood Extracranial Solid Tumor><Childhood Neoplasm><Childhood Tumor><Chromosomal, Gene, or Protein Abnormality><Chromosome 17 Distal Arm><Chromosome 17 Long Arm><Chromosomes><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats interference><Copy Number Polymorphism><Cytogenetic or Molecular Genetic Abnormality><DNA mutation><Danio rerio><Data><Dependence><Differential Gene Expression><Differentiation Therapy><Frequencies><GEM model><GEMM model><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Genes><Genetic><Genetic Abnormality><Genetic Change><Genetic defect><Genetic mutation><Genetically Engineered Mouse><Growth><Histology><Human><Human Chromosomes><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><Implant><In Vitro><Individual><Invaded><Life><Literature><Location><MYCN><MYCN gene><Malignant Neoplasms><Malignant Tumor><Mediating><Mesenchymal><Mice><Mice Mammals><Modeling><Modern Man><Molecular Abnormality><Murine><Mus><Mutation><NMYC><NMYC Gene><Neural Crest Cell><Neuroblastoma><Oncogenes><Oncogenesis><PDX model><Patient derived xenograft><Patients><Pediatric Extracranial Solid Tumor><Pediatric Neoplasm><Pediatric Tumor><Phenotype><Pluripotent Stem Cells><Prevalence><Prognosis><Protocol><Protocols documentation><Publishing><RNA Seq><RNA sequencing><RNAseq><Recurrence><Recurrent><Resistance><Role><Strains Cell Lines><System><Testing><Time><Tissue Growth><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Transcript Expression Analyses><Transcript Expression Analysis><Transforming Genes><Transgenic Mice><Tumor Cell Line><Tumor Promotion><Zebra Danio><Zebra Fish><Zebrafish><adulthood><analyze gene expression><anaplastic lymphoma kinase><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><cancer type><cell growth><cell type><cellular differentiation><chemoresistant><chemotherapy><chemotherapy resistance><chemotherapy resistant><chromosome 17q gain><copy number variant><copy number variation><cultured cell line><differentiation of pluripotent stem cells><entire genome><full genome><gene expression analysis><gene expression assay><genetically engineered mouse model><genetically engineered murine model><genome mutation><hESC><high risk><human ES cell><human ESC><human derived pluripotent stem cell><human embryonic stem cell><human pluripotent stem cell><human progenitor><human stem cells><immunosuppressed patient><in vivo><insight><knock-down><knockdown><malignancy><molecular aberrations><neoplasm/cancer><neuroblastoma cell><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><overexpress><overexpression><patient derived xenograft model><pluripotent progenitor><pluripotent stem cell differentiation><progenitor><progenitor cell differentiation><progenitor cell model><progenitor differentiation><progenitor model><repressing CRISPR-dCas9 system><resistant><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell model><stem and progenitor differentiation><stem cell based model><stem cell derived model><stem cell differentiation><stem cell model><therapeutic target><transcriptional profiling><transcriptome sequencing><transcriptomic sequencing><tumor><tumorigenesis><tumorigenic><tumors in children><vector><whole genome>
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Nicholas Broskey

EAST CAROLINA UNIVERSITY, GREENVILLE, NC

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$552,661
FY 2026

Project Title

Effect of Maternal Exercise in Women with Obesity on Offspring Mesenchymal Stem Cell Metabolism

Grant Number:

5R01DK137945-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/9/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Obesity in pregnancy increases the risk for excessive adiposity in offspring, which tracks into adulthood and can perpetuate across generations. Our preliminary data and published studies indicate that exercise initiated during pregnancy in sedentary women with obesity lowers infant ...

Research Terms

<(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase><21+ years old><5 year old><5 years of age><5'-AMP-activated protein kinase><ACOG><AMP-activated kinase><AMP-activated protein kinase><AMPK enzyme><Adipocytes><Adipose Cell><Adult><Adult Human><Adverse effects><Aerobic Activity><Aerobic Exercise><Aerobic Training><Aerobic fitness><Affect><Age Months><American College of Obstetricians and Gynecologists><American College of Obstetricians and Gynecology><American College of Obstetrics and Gynecologists><American College of Obstetrics and Gynecology><Ancillary Study><BMI><BMI percentile><BMI z-score><Basal Metabolism><Basal metabolic rate><Beta Cell><Bioenergetics><Blood><Blood Reticuloendothelial System><Body Composition><Body Tissues><Body fat><Body mass index><Candidate Disease Gene><Candidate Gene><Cellular Metabolic Process><D-Glucose><DEXA><DXA><Data><Deposit><Deposition><Dextrose><Dual-Energy X-Ray Absorptiometry><Dual-Energy Xray Absorptiometry><Energy Expenditure><Energy Metabolism><Enrollment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exercise><Exposure to><Fat Cells><Fats><Fatty acid glycerol esters><GSK-3beta><GSK-3β><Generations><Genes><Gestation><Glucose><HMG CoA reductase (NADPH) kinase><HMG CoA reductase kinase><HMG coenzyme A reductase (NADPH) kinase><Health><Human><Humulin R><Indirect Calorimetry><Infant><Infant Health><Insulin><Insulin Cell><Insulin Secreting Cell><Intermediary Metabolism><Investigators><Life><Lipids><Lipocytes><Long-term prospective studies><Mature Lipocyte><Mature fat cell><Measures><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mesoderm Cell><Mesodermal Cell><Metabolic><Metabolic Processes><Metabolism><Mitochondria><Modeling><Modern Man><Mothers><Muscle Cells><Myocytes><Novolin R><Obesity><Outcome><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Parents><Pathway interactions><Phenotype><Pregnancy><Pregnant Women><Production><Proteins><Publishing><Quetelet index><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Recommendation><Regular Insulin><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Respiration Calorimetry><Rest><Risk><Role><Testing><Tissues><Translating><Triacylglycerol><Triglycerides><Umbilical Cord><Umbilical cord structure><Weight><Woman><Work><adipogenesis><adiposity><adulthood><adverse consequence><adverse outcome><age 5><age 5 years><candidate identification><care as usual><cell metabolism><cell type><cellular metabaolism><child adiposity><child obesity><childhood adiposity><childhood obesity><corpulence><enroll><epigenetically><exercise modalities><expectant mother><expectant women><expecting mother><expecting women><fetal><five year old><five years of age><glycogen synthase kinase 3 beta><glycogen synthase kinase 3β><hydroxymethylglutaryl-CoA-reductase kinase><improved><indexing><individuals who are pregnant><insulin sensitivity><life style intervention><lifestyle intervention><lipid biosynthesis><lipogenesis><longitudinal, prospective study><maternal adiposity><maternal obesity><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><metabolic profile><metabolism measurement><metabolomics><metabonomics><methylation pattern><mitochondrial><mode of exercise><multiomics><multiple omics><myogenesis><obese children><obesity during childhood><obesity during pregnancy><obesity in children><obesity in pregnancy><obesity risk><offspring><oxidation><panomics><parent><parent grant><pathway><pediatric obesity><people who are pregnant><postnatal><pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><progenitor cell model><progenitor model><randomisation><randomization><randomly assigned><resistance exercise><resistance training><respiratory><resting metabolic rate><risk for obesity><risk of obesity><sedentary><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><those who are pregnant><treatment as usual><usual care><weights><women who are pregnant><β-cell><β-cells><βCell>
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Ya-Chieh Hsu

HARVARD UNIVERSITY, CAMBRIDGE, MA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$509,224
FY 2026

Project Title

Aging and Rejuvenation of Skin Stem Cells

Grant Number:

5R01AR083416-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The regenerative capacity of stem cells diminishes as we age. In the case of hair follicle stem cells (HFSCs), this loss manifests as a sustained dormancy phase without regenerating new hair follicles. Although we have gained substantial insight into the molecular differences between...

Research Terms

<AAV vector><AAV-based vector><Abscission><Address><Adeno-Associated Viruses><Adrenal Gland Excision><Adrenal Glands><Adrenalectomy><Adrenals><Affect><Age><Aging><Assay><Automobile Driving><Behavior><Bioassay><Biological Assay><C57BL/6 Mouse><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chromatin><Chronic stress><Communities><Corticosterone><Data><Defect><Dependoparvovirus><Dependovirus><Dermal><Excision><Experimental Genetics><Extirpation><Fibroblasts><Foundations><Future><Gene Expression><Generalized Growth><Genes><Genetic><Genetic Models><Growth><Hair><Hair Follicle><Hair follicle structure><Immunofluorescence><Immunofluorescence Immunologic><Intracellular Communication and Signaling><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Mammalia><Mammals><Measures><Mediating><Methods><Mice><Mice Mammals><Molecular><Murine><Mus><National Institute of Aging><National Institute on Aging><Natural regeneration><Nature><Null Mouse><Pathway interactions><Phase><Phenotype><Play><Process><Progenitor Cells><RNA Seq><RNA sequencing><RNAseq><Regeneration><Regenerative capacity><Rejuvenation><Removal><Research><Resolution><Rest><Route><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Skin><Skin Aging><Solid><Speed><Stem Cell Research><Stereotyping><Stress><Study models><Surgical Removal><Techniques><Testing><Therapeutic><Tissue Growth><Viral><Virus><Wild Type Mouse><Work><accelerated aging><accelerated biological age><accelerated biological aging><adeno associated virus group><adeno-associated viral vector><adeno-associated virus vector><age acceleration><age associated><age associated alterations><age associated changes><age associated decline><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent decline><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related decline><age specific><age specific alterations><age specific changes><aged><aged mice><aged mouse><aged rodent><aged rodents><aged skin><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><biological signal transduction><changes with age><combat><cost><cutaneous stem cells><decline with age><dermal progenitor><dermal stem cell><develop therapy><differential expression><differentially expressed><driving><elderly mice><elderly rodent><experience><experiment><experimental research><experimental study><experiments><extracellular><gene function><gene manipulation><gene testing><gene-based testing><genetic manipulation><genetic testing><genetically manipulate><genetically perturb><global gene expression><global transcription profile><hair regeneration><in vivo><innovate><innovation><innovative><insight><intervention development><molecular phenotype><old mice><old rodent><ontogeny><overexpress><overexpression><papilla><pathway><progenitor aging><progenitor cell aging><progenitor cell function><progenitor function><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration ability><regeneration capacity><repair><repaired><resection><resolutions><skin photoaging><skin progenitor><skin solar aging><skin stem cell><stem and progenitor cell function><stem and progenitor function><stem cell aging><stem cell function><stem cell study><stem cells><suprarenal gland><therapeutic target><therapy development><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><tongue papilla><tool><transcriptional differences><transcriptome><transcriptome sequencing><transcriptomic sequencing><treatment development><wildtype mouse>
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Shihuan Kuang

DUKE UNIVERSITY, DURHAM, NC

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$507,425
FY 2026

Project Title

Metabolic regulation of muscle satellite cell homeostasis

Grant Number:

5R01DK132819-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Metabolic regulation of muscle satellite cell homeostasis and function Abstract Muscle satellite cells (MuSCs) are resident stem cells in the skeletal muscle responsible for its postnatal growth, maintenance and regeneration. MuSCs in adult homeostatic muscles are predominantly in the quiescent stat...

Research Terms

<21+ years old><Acetylation><Adipocytes><Adipose Cell><Adult><Adult Human><Affect><Aging><Autoregulation><Biochemical><Biogenesis><Catabolism><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Differentiation><Cell Differentiation process><Cell Division Cycle><Cell Fate Control><Cell Fate Regulation><Cell Function><Cell Growth in Number><Cell Multiplication><Cell Nucleus><Cell Physiology><Cell Process><Cell Proliferation><Cell Respiration><Cell Signaling><Cells><Cellular Function><Cellular Metabolic Process><Cellular Physiology><Cellular Process><Cellular Proliferation><Cellular Respiration><Cellular biology><Centrosome><Citric Acid Cycle><Cues><DNA><Data><Degenerative Disorder><Deliberate Self-Harm><Deoxyribonucleic Acid><Development><Embryonic Muscle Cells><Energy Supply><Exhibits><Fat Cells><Fatty Acids><Generalized Growth><Growth><Homeostasis><In Vitro><Injury><Intermediary Metabolism><Intracellular Communication and Signaling><Knowledge><Krebs Cycle><LKB1><LKB1/STK11 Gene><Label><Laboratories><Link><Lipids><Lipocytes><Lipolysis><Maintenance><Maps><Mature Lipocyte><Mature fat cell><Mediating><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Mitochondria><Molecular><Molecular Fingerprinting><Molecular Profiling><Muscle><Muscle Tissue><Muscle function><Muscle satellite cell><Myoblasts><Myogenic Satellite Cells><Natural regeneration><Neural Stem Cell><Nucleus><Nutrient><Organelles><Origin of Life><Pathogenesis><Pathologic><Pattern><Phosphorylation><Physiological Homeostasis><Play><Precursor Muscle Cells><Production><Progenitor Cells><Proliferating><Protein Acetylation><Protein Phosphorylation><Proteins><Regeneration><Regenerative capacity><Regulation><Reporting><Role><STK11><STK11 gene><Self-Injurious Behavior><Signal Transduction><Signal Transduction Systems><Signaling><Sister><Skeletal Muscle><Skeletal Muscle Satellite Cells><Subcellular Process><System><TCA cycle><Testing><Tissue Growth><Translating><Transplantation><Tricarboxylic Acid Cycle><Voluntary Muscle><Work><adipogenesis><adulthood><aerobic metabolism><aerobic respiration><biological signal transduction><cancer cell metabolism><cancer metabolism><cell biology><cell metabolism><cellular differentiation><cellular metabaolism><degenerative condition><degenerative disease><deliberate self harm><developmental><fat metabolism><fatty acid oxidation><glucose metabolism><improved><in vivo><injuries><injury and repair><injury response><insight><intentional self harm><intentional self injury><lipid biosynthesis><lipid mediator><lipid metabolism><lipidomics><lipogenesis><liver kinase B1><metabolism measurement><metabolomics><metabonomics><mitochondrial><molecular profile><molecular signature><muscle fiber repair><muscle regeneration><muscle repair><muscle tissue repair><muscular><muscular repair><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><novel><ontogeny><oxidative metabolism><postnatal><progenitor and neural stem cells><progenitor biology><progenitor cell biology><progenitor cell fate><progenitor cell function><progenitor cell pool><progenitor cell population><progenitor fate><progenitor function><progenitor pool><progenitor population><regenerate><regeneration ability><regeneration capacity><regeneration function><regenerative function><regenerative functionality><response to injury><satellite cell><segregation><self harm><self injury><self renewing cell><self-renew><self-renewal><social role><stem and progenitor biology><stem and progenitor cell fate><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor function><stem cell biology><stem cell fate><stem cell function><stem cell pool><stem cell population><stem cells><tissue progenitor><tissue specific progenitor cells><tissue specific stem cells><tissue stem cells><transplant><tumor cell metabolism><tumor metabolism>
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Hanna Katri Annikki Mikkola

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$506,970
FY 2026

Project Title

REGULATION OF HUMAN HEMATOPOIETIC STEM CELL FATE VIA MLLT3 ISOFORMS

Grant Number:

5R01DK121557-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/16/2019

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY We discovered that MLLT3 is a key regulator of human hematopoietic stem cell (HSC) self-renewal but its expression declines in culture. Strikingly, maintaining MLLT3 levels in cultured cord blood (CB) HSCs results in expansion of transplantable HSCs without transformation or differentiation ...

Research Terms

<AF-9 protein><AF9><AF9 protein><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Anabolism><Autoregulation><Binding><Biology><Blood Diseases><Blood Precursor Cell><Cell Body><Cell Culture Techniques><Cell Function><Cell Line><Cell Maturation><Cell Ontogeny><Cell Physiology><Cell Process><CellLine><Cells><Cellular Assay><Cellular Function><Cellular Physiology><Cellular Process><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Clinical><Complex><Cord Blood><Cord Blood Hematopoietic progenitor><Cord Blood Hematopoietic stem cells><Data><Development><Elements><Embryo><Embryonic><Engraftment><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equilibrium><Exons><Fetal Liver><Gene Transcription><Generalized Growth><Generations><Genetic Transcription><Growth><HSC differentiation><HSC expansion><HSC regeneration><HSC self-renewal><HSC transplantation><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoietic><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Homeostasis><Human><Immunochemical Immunologic><Immunodeficient Mouse><Immunologic><Immunologic Subtyping><Immunological><Immunologically><Immunologics><Immunophenotyping><Isoforms><LTG9 protein><Life><Link><MLLT-3 protein><MLLT3><MLLT3 gene><MLLT3 protein><Maintenance><Maps><Minority><Mitochondria><Modern Man><Molecular><Molecular Interaction><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Parents><Patients><Physiologic><Physiological><Physiological Homeostasis><Protein Isoforms><Protein Truncation><Proteins><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Regulation><Regulator Genes><Regulatory Element><Repression><Stem Cell Development><Stem Cell like><Strains Cell Lines><Subcellular Process><Tissue Growth><Transcript><Transcription><Transcriptional Regulatory Elements><Translations><Trithorax Homolog 3><Umbilical Cord Blood><Undifferentiated><Variant><Variation><balance><balance function><biosynthesis><blood cell progenitor><blood disorder><blood progenitor><blood progenitor cell expansion><blood progenitor expansion><blood stem cell><blood stem cell expansion><blood stem cell regeneration><blood stem cell self-renewal><blood stem cell transplantation><blood treatment><blood-forming stem cell><cell assay><cell culture><cell cultures><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><cohesin><cultured cell line><developmental><epigenetically><fetal><fetal cord blood><gain of function><genetic trans acting element><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell differentiation><hematopoietic progenitor cell expansion><hematopoietic progenitor cell fate><hematopoietic progenitor cell self-renewal><hematopoietic progenitor cell transplantation><hematopoietic progenitor differentiation><hematopoietic progenitor expansion><hematopoietic stem and progenitor cell fate><hematopoietic stem cell differentiation><hematopoietic stem cell expansion><hematopoietic stem cell fate><hematopoietic stem cell regeneration><hematopoietic stem cell self-renewal><hematopoietic stem progenitor cell><hemogenic endothelium><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><knock-down><knockdown><leukemia><loss of function><mitochondrial><mitochondrial metabolism><multiomics><multiple omics><nanopore based sequencing><nanopore long read seq><nanopore long-read sequencing><nanopore seq><nanopore sequencing><nanopore-based long-read sequencing><new approaches><novel><novel approaches><novel strategies><novel strategy><ontogeny><overexpress><overexpression><panomics><parent><premature><prematurity><prevent><preventing><progenitor capacity><progenitor cell development><progenitor cell function><progenitor cell like><progenitor development><progenitor function><progenitor-like><programs><protein protein interaction><regeneration of blood stem cells><regulatory gene><scRNA sequencing><scRNA-seq><self - renewal in hematopoietic stem cells><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><stem and progenitor cell development><stem and progenitor cell function><stem and progenitor function><stem cell characteristics><stem cell function><stem-like><stemness><success><trans acting element><transcriptome sequencing><transcriptomic sequencing><translation>
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Weston W Porter

TEXAS A&M AGRILIFE RESEARCH, College Station, TX

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$503,769
FY 2026

Project Title

Circadian Regulation of Cellular Homeostasis

Grant Number:

5R01ES033601-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/18/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Biological clocks play a key role in how organisms adapt to daily (circadian), monthly (circalunar), and annual (circannual) changes in the environment by regulating rhythmic fluctuations in metabolism, hormone and neurotransmitter release, sensory capabilities and behaviors, including sleep. Disrup...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Autoregulation><Basal Cell><Basal Transcription Factor><Basal transcription factor genes><Behavior><Beta Cadherin-Associated Protein><Beta-1 Catenin><Biologic Models><Biological Clocks><Biological Models><Bone-Derived Transforming Growth Factor><Breast Cancer><Breast Epithelial Cells><CUL-2><Cancers><Causality><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Lineage><Cell Signaling><Cells><Cellular Regulation><Chronic><Circadian Dysregulation><Circadian Rhythms><Cyclicity><Data><Development><Disease><Disorder><Down-Regulation><Duct><Duct (organ) structure><Embryo Development><Embryogenesis><Embryonic Development><Endocrine Gland Secretion><Environment><Etiology><Expression Signature><Eye><Eyeball><Gene Action Regulation><Gene Expression><Gene Expression Profile><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Transcription><Gestation><Health><Heterogeneity><Homeostasis><Hormones><Intermediary Metabolism><Intervention Strategies><Intracellular Communication and Signaling><Jet Lag><Jet Lag Syndrome><Jetlag><Jetlag Syndrome><Lactation><Light><Lineage Tracing><MCF-10A><MCF10A><MCF10A cells><Malignant Breast Neoplasm><Malignant Neoplasms><Malignant Tumor><Mammary gland><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolism><Mice><Mice Mammals><Milk Growth Factor><Model System><Modeling><Molecular><Morphogenesis><Murine><Mus><Nyctohemeral Rhythm><Organism><PRO2286><Periodicity><Phenotype><Phosphatases><Phosphohydrolases><Phosphomonoesterases><Phosphoric Monoester Hydrolases><Photoradiation><Physiologic><Physiological><Physiological Homeostasis><Platelet Transforming Growth Factor><Play><Population><Pregnancy><Process><Progenitor Cells><Proliferating><Puberty><RNA Expression><Regulation><Reporter><Rhythmicity><Risk><Role><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Sleep><Sleep Disorders><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Testing><Therapeutic><Therapeutic Hormone><Therapeutic Intervention><Thesaurismosis><Time><Time Zone Change Syndrome><Time Zone Syndrome><Tissue Differentiation><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Twenty-Four Hour Rhythm><Vulnerable Populations><WNT Signaling Pathway><WNT signaling><Working Women><adulthood><basal progenitor><basal stem cell><beta cat><beta catenin><biological signal transduction><body clock><breast epithelium><cancer progenitor><cancer progenitor cells><cancer stem cell><cancer stem like cell><causation><cell behavior><cell growth regulation><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular behavior><cellular differentiation><cellular lineage mapping><cellular lineage tracking><circadian><circadian abnormality><circadian clock><circadian disruption><circadian disturbance><circadian dysfunction><circadian impairment><circadian pacemaker><circadian process><circadian regulation><circadian rhythmicity><daily biorhythm><day shift><developmental><differential expression><differentially expressed><disease causation><gene expression pattern><gene expression signature><internal clock><intervention therapy><lactating><lactational><living system><malignancy><malignant breast tumor><malignant progenitor><malignant stem cell><mammary><mammary epithelial cells><mammary epithelium><mammary gland development><mammary gland epithelial cells><mammary gland morphogenesis><mammary morphogenesis><metabolism disorder><morphogenetic process><neoplasm/cancer><neurotransmitter release><night shift><night work><novel><oncogenic progenitor><oncogenic stem cells><progenitor biology><progenitor cell biology><progenitor cell fate><progenitor cell homeostasis><progenitor fate><progenitor like cancer cell><risk for stroke><risk of stroke><scRNA sequencing><scRNA-seq><self-renew><self-renewal><shift work><shiftwork><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><sleep diseases><sleep dysfunction><sleep illness><sleep problem><social><social role><stem><stem and progenitor biology><stem and progenitor cell fate><stem cell biology><stem cell fate><stem cell homeostasis><stem cells><stem like cancer cell><stroke risk><transcription factor><transcriptional differences><transcriptional profile><transcriptional signature><vulnerable group><vulnerable individual><vulnerable people><working females><β-catenin>
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Mitra Lavasani

REHABILITATION INSTITUTE OF CHICAGO D/B/A SHIRLEY RYAN ABILITYLAB, CHICAGO, IL

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$477,017
FY 2026

Project Title

Improving Aged Neuromuscular Health and Function

Grant Number:

5R01AG073223-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Loss of neuromuscular function and regenerative capacity is a hallmark of aging; however, the cause of this age- related decline and the molecular pathways underlying this process remain unknown and no clinical intervention successfully arrests age-related neuromuscular dysfunction. ...

Research Terms

<21+ years old><Activities of Daily Living><Activities of everyday life><Adult><Adult Human><Aging><Anatomic Sites><Anatomic structures><Anatomy><Antibodies><Area><Biological><Blood Serum><Body Tissues><Brain><Brain Nervous System><Cell Body><Cell Transplantation><Cells><Cessation of life><Chemotactic Cytokines><Chronic><Clinical><Clinical Treatment><Critical Paths><Critical Pathways><Data><Death><Defect><Dissection><Dysfunction><Elderly><Electron Microscopy><Encephalon><Endocrine><Environment><Exercise><Fiber><Fibrosis><Functional disorder><Gait><Growth Agents><Growth Factor><Growth Substances><Health><Histology><Homologous Chemotactic Cytokines><Hutchinson-Gilford Disease><Hutchinson-Gilford Syndrome><Impairment><Intercrines><Knowledge><Mammalia><Mammals><Measurement><Mediating><Methods><Mice><Mice Mammals><Molecular><Motor><Multipotent Stem Cells><Murine><Mus><Muscle><Muscle Fatigue><Muscle Tissue><Muscular Fatigue><Natural regeneration><Nerve Conduction><Nerve Degeneration><Nerve Regeneration><Nerve Tissue><Nervous Tissue><Neural Conduction><Neuro-regeneration><Neuromuscular conditions><Neuron Degeneration><Neuroregeneration><Parabiosis><Pathology><Pathway interactions><Peripheral Nerves><Physiologic><Physiological><Physiopathology><Premature Senility Syndrome><Process><Progenitor Cell Transplantation><Progenitor Cells><Progeria><Proteins><Proteins Growth Factors><Proteomics><Publishing><QOL><Quality of life><Recovery of Function><Regeneration><Regenerative capacity><Rejuvenation><Role><SIS cytokines><Serum><Signal Pathway><Skeletal Muscle><Specificity><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Stem Cell Transplantation><Stem cell transplant><Stimulus><Structure><System><Techniques><Testing><Therapeutic><Therapeutic Effect><Therapeutic Uses><Time><Tissues><Transplantation><Voluntary Muscle><Weight><adulthood><advanced age><age associated><age associated decline><age associated deterioration><age correlated><age dependent><age dependent decline><age linked><age related><age related decline><age related deterioration><age reversal><age specific><aged><aged animal><aged animals><aged mice><aged mouse><aged muscle><aging associated><aging associated disease><aging associated disorders><aging of muscle><aging prevention><aging related><aging related disease><aging related disorders><aging reversal><alleviate age related><alleviate aging><ameliorating aging><animal old age><anti aging><anti geronic><antiaging><biologic><cellular transplant><chemoattractant cytokine><chemokine><circulating biomarkers><circulating markers><clinical intervention><clinical relevance><clinical therapy><clinical translation><clinically relevant><clinically translatable><counter age related><counter aging><counteract age related><counteract aging><cytokine><daily living function><daily living functionality><decline with age><differential expression><differentially expressed><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><effective therapy><effective treatment><elderly animal><elderly mice><exercise capacity><experiment><experimental research><experimental study><experiments><fall injury><fall related injury><fall risk><functional ability><functional capacity><functional improvement><functional recovery><geriatric><hallmarks of aging><high risk><improve function><improved><improved functional outcomes><injurious falls><life span><lifespan><light microscopy><mouse model><multipotency><multipotent><multipotent cell><multipotent progenitor><multipotent progenitor cell><murine model><muscle aging><muscle bulk><muscle form><muscle mass><muscle regeneration><muscle strength><muscular><myelination><neovascularization><nervous system regeneration><neural degeneration><neural regeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuromuscular><neuromuscular function><neuronal degeneration><neuroregenerative><new approaches><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel approaches><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><old animals><old mice><older adult><older adulthood><paracrine><pathophysiology><pathway><peripheral nerve regeneration><phospho-proteomics><phosphoproteomics><pillars of aging><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prevent age related><prevent aging><progenitor cell based therapy><progenitor cell pool><progenitor cell population><progenitor cell therapy><progenitor cell treatment><progenitor pool><progenitor population><progenitor therapy><progenitor transplantation><progenitor treatment><regenerate><regenerate new tissue><regenerate tissue><regenerated nerve><regenerating damaged tissue><regenerating tissue><regeneration ability><regeneration capacity><rejuvenating intervention><rejuvenation approach><rejuvenation strategies><rejuvenation therapy><rejuvenation treatment><response><restoration><reverse age><reverse aging><reverse aging effects><reversible aging><sarcopenia><sarcopenic><sciatic nerve><senior citizen><skeletal muscle atrophy><skeletal muscle breakdown><skeletal muscle loss><skeletal muscle protein loss><skeletal muscle wasting><social role><stem and progenitor cell population><stem and progenitor cell therapy><stem and progenitor cell transplantations><stem cell based therapy><stem cell mediated therapy><stem cell pool><stem cell population><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><suppress aging><tandem mass spectrometry><therapeutic rejuvenation><therapeutic target><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptional differences><transplant><trial regimen><trial treatment><weights>
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Megan McNerney

UNIVERSITY OF CHICAGO, CHICAGO, IL

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$465,400
FY 2026

Project Title

Establishing CUX1 as a determinant of hematopoietic stem cell fate

Grant Number:

5R01HL166184-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY A longstanding question in developmental biology is how stem cells commit to a certain lineage. While cell surface markers correlate with hematopoietic stem cell (HSC) functions, less is known regarding transcriptional regulators that drive stem cell behavior. CUX1 encodes a highly c...

Research Terms

<57-kD BRG1-Associated Factor><Acute leukemia><Address><Anemia><Assay><BAF57><Basal Transcription Factor><Basal transcription factor genes><Binding><Bioassay><Biological Assay><Blood><Blood Precursor Cell><Blood Reticuloendothelial System><Blood megakaryocyte><Cell Body><Cell surface><Cells><Chromatin><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><DNA><DNA mutation><Data><Defect><Deoxyribonucleic Acid><Development><Developmental Biology><Developmental Gene><Disease><Disorder><Dysmyelopoietic Syndromes><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Erythroid><Exhibits><Family><Fluorochrome><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genomic approach><Goals><HSC differentiation><Hematology><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterogeneity><Homeo Domain><Human><Intervention><Investigation><Knowledge><Lead><Length><Lymphoid><Measures><Megakaryocytes><Megalokaryocyte><Methodology><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Interaction><Monosomy 7><Multipotent Stem Cells><Murine><Mus><Mutation><Myelodysplastic Disease><Myelodysplastic Syndromes><Myelopoiesis><Nucleosomes><Pathogenesis><Patients><Pb element><Peptide Domain><Prevalence><Process><Production><Progenitor Cells><Prognosis><Proliferating><Protein Domains><Proteins><Public Health><QOL><QOL improvement><Quality of life><RNA Expression><Recurrence><Recurrent><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Reporter><Reporting><Role><SMARCE1><SMARCE1 gene><Series><Smoldering Leukemia><Somatic Mutation><Tertiary Protein Structure><Testing><Therapeutic><Therapeutic Intervention><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Tumor Suppressor Proteins><Upregulation><Work><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cell behavior><cellular behavior><chromatin modifier><chromatin protein><chromatin remodeling><chromosome 7q loss><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><cytopenia><del(7q)><developmental><dosage><epigenetically><experiment><experimental research><experimental study><experiments><functional genomics><genome mutation><genomic effort><genomic strategy><global gene expression><global transcription profile><heavy metal Pb><heavy metal lead><hematopoietic cell clones><hematopoietic progenitor><hematopoietic progenitor cell differentiation><hematopoietic progenitor cell fate><hematopoietic progenitor differentiation><hematopoietic stem and progenitor cell fate><hematopoietic stem cell clonality><hematopoietic stem cell differentiation><hematopoietic stem cell fate><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><homeodomain><improved><improvements in QOL><improvements in quality of life><in vivo><intervention therapy><knock-down><knockdown><loss of function mutation><multipotent progenitor><multipotent progenitor cell><myelodysplasia><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><progenitor><progenitor cell function><progenitor function><progression risk><quality of life improvement><recruit><self-renew><self-renewal><single cell analysis><social role><somatic variant><stem><stem and progenitor cell function><stem and progenitor function><stem cell function><stem cells><transcription factor><transcriptome><tumor><tumor suppressor>
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Jeffrey Alan Magee

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$459,111
FY 2026

Project Title

The role of Kmt2c/MLL3 in hematopoietic stem cell self-renewal, commitment and exhaustion

Grant Number:

5R01HL152180-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2020

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY The overarching goal of this proposal is to understand how two highly homologous epigenetic regulators, MLL3 and MLL4, coordinate critical cell fate decisions during adult blood development. Considerable prior work has gone into understanding the transcription factor networks that co...

Research Terms

<21+ years old><Address><Adopted><Adult><Adult Human><Assay><Autoregulation><B blood cells><B cell><B cells><B-Cell Development><B-Cells><B-Lymphocytes><B-cell><Basal Transcription Factor><Basal transcription factor genes><Binding><Binding Proteins><Binding Sites><Bioassay><Biochemical><Biological Assay><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Body System><CUT&RUN><Cancers><Cell Body><Cell Lineage><Cells><Chromatin><Cleavage Targets and Release Using Nuclease><Cleavage Under Targets and Release Using Nuclease><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Combining Site><Complex><DNA Binding><DNA Binding Interaction><DNA bound><Development><Disease><Disorder><EC 2.1.1><Enhancer Elements><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><GEM model><GEMM model><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Enhancer Element><Genetic Transcription><Genetically Engineered Mouse><Genomics><Goals><HSC regeneration><HSC self-renewal><Hematologic Body System><Hematologic Diseases><Hematologic Organ System><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic><Hematopoietic Body System><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic System><Hematopoietic stem cells><Histone H3><Homeostasis><Human><Immune system><Inflammatory><L-Lysine><Learning><Licensing><Ligand Binding Protein><Ligand Binding Protein Gene><Logic><Lymphoid><Lysine><Malignant Neoplasms><Malignant Tumor><Maps><Mediating><Methyltransferase><Modern Man><Molecular Interaction><Multipotent Stem Cells><Mutate><Myelogenous><Myeloid><Organ System><Physiological Homeostasis><Position><Positioning Attribute><Production><Protein Binding><Proteins><Proteomics><RNA Expression><Reactive Site><Regulatory Element><Role><SET Domain><Shapes><Techniques><Touch><Touch sensation><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Work><adulthood><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell regeneration><blood stem cell self-renewal><blood-forming stem cell><bone marrow failure syndrome><bound protein><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><cofactor><cohort><developmental><enhancer sequence><epigenetic regulation><epigenetically><exhaustion><experiment><experimental research><experimental study><experiments><genetic enhancer sequence><genetically engineered mouse model><genetically engineered murine model><hematopoietic cell clones><hematopoietic differentiation><hematopoietic progenitor><hematopoietic progenitor cell self-renewal><hematopoietic stem cell clonality><hematopoietic stem cell regeneration><hematopoietic stem cell self-renewal><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><histone H3 methyltransferase><histone methylase><histone methyltransferase><hypoimmunity><immune deficiency><immunodeficiency><insight><leukemia><malignancy><methylase><multipotent progenitor><multipotent progenitor cell><neoplasm/cancer><progenitor><programs><protein complex><recruit><regeneration of blood stem cells><self - renewal in hematopoietic stem cells><social role><tactile sensation><transcription factor><transmethylase>
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Mansi Srivastava

HARVARD UNIVERSITY, CAMBRIDGE, MA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$456,300
FY 2026

Project Title

Stem cell regulation during development and whole-body regeneration

Grant Number:

5R35GM153252-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Although the early embryos of humans and other vertebrates have pluripotent cells that can differentiate into all cell types of the animal, these flexible cells are absent in adults. In contrast, many invertebrate animals maintain pluripotency beyond embryogenesis, and harbor adult p...

Research Terms

<21+ years old><Adult><Adult Human><Animals><Biologic Models><Biological Models><Biology><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Adhesion><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Lineage><Cells><Cellular Adhesion><Chromatin><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Development><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Evolution><Gene Transcription><Gene Transfer Techniques><Genes><Genetic Transcription><Genomic approach><Goals><Hand><Human><Human Biology><Image><Invertebrata><Invertebrates><Knowledge><Label><Lineage Tracing><Methods><Mission><Model System><Modern Man><Molecular><NIH><National Institutes of Health><Natural regeneration><Organism><Planarians><Pluripotent Stem Cells><Post-Transcriptional Gene Silencing><Progenitor Cells><Public Health><RNA Expression><RNA Interference><RNA Silencing><RNAi><Regeneration><Regenerative Medicine><Regenerative research><Regulation><Research><Sequence-Specific Posttranscriptional Gene Silencing><System><Techniques><Tissues><Transcription><Transgenesis><United States National Institutes of Health><Vertebrate Animals><Vertebrates><adult animal><adulthood><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell regeneration><cell type><cellular differentiation><cellular lineage mapping><cellular lineage tracking><cellular regeneration><decrease disability><decrease in disability><developmental><disability reduction><experiment><experimental research><experimental study><experiments><flexibility><flexible><functional genomics><gene function><genome scale><genome-wide><genomewide><genomic effort><genomic strategy><global gene expression><global transcription profile><hands><imaging><in vivo><innovate><innovation><innovative><lessen disability><living system><mature animal><minimize disability><mitigate disability><new approaches><novel><novel approaches><novel strategies><novel strategy><pluripotency><pluripotent progenitor><pluripotent state><progenitor biology><progenitor cell biology><programs><reduction in disability><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration research><regeneration studies><regenerative studies><slow disability><stem and progenitor biology><stem cell biology><stem cells><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptome><vertebrata>
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Stavros Thomopoulos

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$452,117
FY 2026

Project Title

Formation of a functional tendon enthesis during development and healing

Grant Number:

5R01AR080717-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY/ABSTRACT Tendon injuries often occur near their bony attachments, requiring surgical repair of tendon to bone. Outcomes after repair, however, are poor and result in pain, reinjury, and repeated surgeries. Rotator cuff repair, for example, is among the most common shoulder surgeries, yet is ...

Research Terms

<21+ years old><ACL injury><Ablation><Acute><Adult><Adult Human><Agonist><Architecture><Assay><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biological Assay><Biomechanics><Body Tissues><Cartilage><Cartilaginous Tissue><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Lineage><Cell Signaling><Cell-Extracellular Matrix><Cells><Chondrocytes><Cicatrix><Connective Tissue><Cues><Development><Differentation Markers><Differentiation Antigens><Differentiation Markers><ECM><Embryo><Embryonic><Engineering / Architecture><Erinaceidae><Event><Extracellular Matrix><Failure><Fibrocartilages><Future><GLI Family Gene><GLI Family Protein><GLI Protein><GLI gene><GLI1><GLI1 Gene><GLI1 Protein><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genetic><Genetic Transcription><Glioma Associated Oncogene Homolog 1 Protein><Glioma Associated Oncogene Homolog Protein><Glioma-Associated Oncogene Homolog><Glioma-associated oncogene><Goals><Growth><Health><Hedgehog (Hh) signal transduction pathway><Hedgehogs><Individual><Injury><Intracellular Communication and Signaling><Knee><Knowledge><Marker Antigens><Mechanics><Mediating><Mice><Mice Mammals><Minerals><Modeling><Molecular><Morphology><Murine><Mus><Muscle><Muscle Tissue><Natural regeneration><Neonatal><Older Population><Operative Procedures><Operative Surgical Procedures><Outcome><Pain><Painful><Pathway interactions><Phenotype><Physiologic><Physiological><Pilot Projects><Population><Process><Progenitor Cells><QOL><Quality of life><RNA Expression><Regeneration><Reoperation><Repeat Surgery><Reporter><Research><Role><Rotator Cuff><Rupture><Scars><Shoulder><Signal Transduction><Signal Transduction Systems><Signaling><Site><Stress><Surgical><Surgical Interventions><Surgical Procedure><Tendon Injuries><Tendon structure><Tendons><Testing><Therapeutic><Tissue Growth><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><United States><Work><adulthood><anterior cruciate ligament injury><biological signal transduction><biomechanical><bone><bone healing><bone repair><bone wound healing><cellular differentiation><clinical significance><clinically significant><developmental><driving><enthesis progenitors><enthesis stem cells><fetal><fibrocartilaginous><gain of function><glioma associated oncogene 1><glioma associated oncogene family zinc finger 1><global gene expression><global transcription profile><healing><hedgehog signaling><hedgehog signaling pathway><hh signaling pathway><improved><injuries><loss of function><mechanic><mechanical><mechanical properties><mineralization><muscular><older groups><older individuals><older person><ontogeny><osseous wound healing><pathway><patient population><pilot study><post-natal development><postnatal><postnatal development><prevent><preventing><progenitor cell based therapy><progenitor cell differentiation><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor cell therapy><progenitor cell treatment><progenitor differentiation><progenitor niche><progenitor pool><progenitor population><progenitor therapy><progenitor treatment><programs><regenerate><regenerative><regenerative approach><regenerative strategy><regenerative technique><repair><repaired><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><smoothened signaling pathway><social role><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor cell therapy><stem and progenitor differentiation><stem cell based therapy><stem cell differentiation><stem cell mediated therapy><stem cell niche><stem cell pool><stem cell population><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><surgery><transcription factor><transcriptome>
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Bradley B Olwin

UNIVERSITY OF COLORADO, Boulder, CO

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$451,607
FY 2026

Project Title

Mechanisms Regulating Muscle Stem Cell Homeostasis

Grant Number:

5R01AR049446-19

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2005

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Skeletal muscle tissue is essential for life, requiring continuous maintenance and repair by a resident population of skeletal muscle stem cells or satellite cells (SCs). Maintenance and repair of skeletal muscle re- quires fusion of SCs into existing myofibers or fusion of SCs with...

Research Terms

<Affect><Aging><Anatomic Sites><Anatomic structures><Anatomy><Basement membrane><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Multiplication><Cell Nucleus><Cell Proliferation><Cell Signaling><Cell Transplantation><Cell division><Cell fusion><Cell membrane><Cells><Cellular Proliferation><Coupled><Cytoplasmic Membrane><Data><Disease><Disorder><Embryonic Muscle Cells><Ensure><Environment><Fibroblasts><Gene Transcription><Genetic Transcription><Goals><Health><Health Care><Heterogeneity><Hypertrophy><Injury><Intracellular Communication and Signaling><Knowledge><Life><Lineage Tracing><Maintenance><Methodology><Methods><Mitotic><Mononuclear><Morbidity><Muscle><Muscle Disease><Muscle Disorders><Muscle Fibers><Muscle Tissue><Muscle function><Muscle satellite cell><Muscular Diseases><Myoblasts><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Myotubes><Nuclear><Nucleus><Parents><Peripheral><Plasma Membrane><Population><Population Heterogeneity><Position><Positioning Attribute><Precursor Muscle Cells><Production><Progenitor Cells><Proliferating><QOL><Quality of life><RNA Expression><Rhabdomyocyte><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Technology><Tissues><Transcription><Voluntary Muscle><biological signal transduction><cell behavior><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular behavior><cellular lineage mapping><cellular lineage tracking><cellular transplant><combat><daughter cell><diverse populations><experiment><experimental research><experimental study><experiments><flexibility><flexible><heterogeneous population><improved><injuries><muscle fiber repair><muscle progenitor><muscle progenitor cell><muscle regeneration><muscle repair><muscle stem cell><muscle tissue repair><muscular><muscular disorder><muscular repair><new approaches><novel><novel approaches><novel strategies><novel strategy><parent><plasmalemma><population diversity><prevent><preventing><progenitor><progenitor cell homeostasis><repair><repaired><satellite cell><single cell next generation sequencing><single cell sequencing><stem cell homeostasis><stem cells><therapeutic agent development><therapeutic development><therapeutic target><transcriptomics>
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Sami Nimer Malek

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$450,501
FY 2026

Project Title

Genes regulating stem and progenitor cell expansion and relapse in Acute Myeloid Leukemia

Grant Number:

5R01CA291806-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2025

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Acute myelogenous leukemia (AML) is diagnosed in 21,450 adult patients in the US per year with a five-year survival rate of 29%. Standard AML therapy comprises chemotherapy induction to achieve leukemia cytoreduction, followed by cycles of consolidation chemotherapy alone and/or followed by allogene...

Research Terms

<21+ years old><AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Adult><Adult Human><Affect><Age><Allo BMT><Allogeneic BMT><Allogeneic Bone Marrow Transplantation><Antioncogene Protein p53><Apical><Area><B23><Blood Cells><Blood Precursor Cell><Bone Marrow><Bone Marrow Reticuloendothelial System><C-K-RAS><CD34><CD34 gene><CRISPR approach><CRISPR based approach><CRISPR editing screen><CRISPR method><CRISPR methodology><CRISPR screen><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based screen><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 screen><CRISPR/Cas9 technology><Candidate Disease Gene><Candidate Gene><Cas nuclease technology><Cell Body><Cell Survival><Cell Viability><Cells><Cellular Tumor Antigen P53><Cerubidin><Cessation of life><Chemotherapy Protocol><Chemotherapy Regimen><Chemotherapy-Oncologic Procedure><Clinical><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Combination Chemotherapy Regimen><Credentialing><Cytogenetics><DNA mutation><DNMT3a><Data><Dauno-Rubidomycine><Daunoblastina><Daunoblastine><Daunomycin><Daunorrubicina><Daunorubicin><Death><Development><Diagnosis><Disease><Disease remission><Disorder><Dose><Effectiveness><Exposure to><FLK2><FLT3><FLT3 gene><FMS-like tyrosine kinase 3><Fms-Related Tyrosine Kinase 3><Gene Alteration><Gene Inactivation><Gene Mutation><Gene Pool><Gene Silencing><General Prognostic Factor><Generalized Growth><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Growth><HPCA1><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterograft><Heterologous Transplantation><Human><K-RAS2A><K-RAS2B><K-Ras><K-Ras 2A><K-Ras-2 Oncogene><KRAS><KRAS2><KRAS2 gene><Ki-RAS><Leukaemomycin C><Leukemic Cell><Leukemic progenitor and stem cell><Life><Measurement><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutation><N-RAS><NPM><NPM1><NPM1 gene><NRAS gene><Neuroblastoma RAS viral oncogene><Non-Malignant><Oncogene K-Ras><Oncoprotein p53><Ondena><P53><Pathogenesis><Pathway interactions><Patients><Peripheral Blood Cell><Phase><Phenotype><Phosphoprotein P53><Phosphoprotein pp53><Population><Preleukemia><Process><Productivity><Progenitor Cells><Prognostic Factor><Prognostic/Survival Factor><Property><Protein TP53><Publishing><Quimioterapia><R Plasmids><RASK2><Recurrence><Recurrent><Recurrent disease><Relapse><Relapsed Disease><Remission><Resistance><Risk><Rubidomycin><Rubilem><Rubomycin><Rubomycin C><STK-1 kinase><STK1><Sampling><Spinal Column><Spine><Stem Cell Tyrosine Kinase 1><Survival Rate><TP53><TP53 gene><TRP53><Therapeutic><Tissue Growth><Tumor Protein p53><Tumor Protein p53 Gene><Validation><Vertebral column><Work><Xenograft><Xenograft Model><Xenograft procedure><Xenotransplantation><acute granulocytic leukemia><acute granulocytic leukemia cell><acute leukemia cell><acute myeloblastic leukemia cell><acute myelocytic leukemia cell><acute myelogenous leukemia cell><acute myeloid leukemia><acute myeloid leukemia cell><acute nonlymphocytic leukemia cell><adulthood><ages><allogeneic bone marrow transplant><allogenic bone marrow transplant><backbone><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><bone marrow allograft><cancer chemotherapy><cell type><cerubidine><chemotherapy><clinical practice><clinical remission><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><clustered regularly interspaced short palindromic repeats screen><developmental><fetal liver kinase-2><fetal liver kinase-3><gene defect><genome mutation><hDNA methyltransferase 3a><hematopoietic cell clones><hematopoietic progenitor><hematopoietic stem cell clonality><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><human model><human progenitor><human stem cells><improved><innovate><innovation><innovative><interest><irradiation><leukemia><leukemia relapse><leukemia stem/initiating cells><leukemia treatment><leukemic progenitor><leukemic stem cell><leukemic therapy><leukemic transformation><model of human><mutant allele><nonmalignant><novel><ontogeny><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pathway><progenitor biology><progenitor cell biology><progenitor cell expansion><progenitor expansion><protein p53><recurrent leukemia><resistance factors><resistant><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><stem><stem and progenitor biology><stem and progenitor cell expansion><stem cell biology><stem cell expansion><stem cells><transcriptional silencing><v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog><validations><xeno-transplant><xeno-transplantation><xenograft transplant model><xenotransplant model>
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Sahand Hormoz

DANA-FARBER CANCER INST, BOSTON, MA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$445,000
FY 2026

Project Title

Elucidating the Origins and Drivers of Clonal Dynamics in Hematopoiesis

Grant Number:

1R35HL183474-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2026

End Date:

12/31/2032

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

The human body produces hundreds of billions of blood cells daily, replenished by hematopoietic stem cells (HSCs) in the bone marrow. Over time, HSC clones—populations derived from a single HSC—fluctuate in size, with some clones expanding while others dwindle. Clonal dynamics have been studied by r...

Research Terms

<Address><Aging><Blood><Blood Cells><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Bone Marrow><Bone Marrow Reticuloendothelial System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clonal Expansion><Clonal Hematopoietic Stem Cell><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><DNA><DNA methylation profiling><Deoxyribonucleic Acid><Development><Diagnosis><Engineering><Event><Genetic><HSC heterogeneity><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic Cell Tumor><Hematopoietic Cellular Control Mechanisms><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell heterogeneity><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Hematopoietic stem cells><History><Human><Human Figure><Human body><Individual><Intracellular Communication and Signaling><Intrinsic factor><JAK-2><JAK2><JAK2 gene><JAK2 protein><Janus kinase 2><Knowledge><Malignant Hematopoietic Neoplasm><Maps><Measurement><Methods><Methyl-Seq><MethylSeq><Methylation sequencing><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Myeloid Disease><Myeloid Malignancy><Myeloid Neoplasm><Myeloid Tumor><Myeloproliferative Disorders><Myeloproliferative Tumors><Myeloproliferative disease><Peripheral Blood Cell><Phylogenetic Analysis><Phylogenetics><Phylogeny><Population><Progenitor Cells><Prognosis><Recording of previous events><Regulation><Research><Sampling><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Somatic Mutation><Technology><Therapeutic><Time><Trees><Tyrosine-Protein Kinase JAK2><Work><biological signal transduction><blood cancer><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell heterogeneity><blood-forming stem cell><cancer of blood><cancer of the blood><clonal expansions in the blood><clonal hematopoiesis><clone hematopoietic stem cell><clones in hematopoietic cells><cost><cost effective><developmental><driver lesion><driver mutation><entire genome><fitness><full genome><genome sequencing><hematopoietic cell clones><hematopoietic progenitor><hematopoietic stem cell clonality><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><heterogeneity within hematopoietic stem cells><heterogeneous blood stem cells><heterogeneous hematopoietic stem cells><histories><improved><life span><lifespan><methylation pattern><mouse model><murine model><mutant><myeloproliferative neoplasm><new technology><novel technologies><progenitor cell pool><progenitor cell population><progenitor pool><progenitor population><prognosis model><prognostic model><programs><single cell next generation sequencing><single cell sequencing><somatic variant><stem and progenitor cell population><stem cell pool><stem cell population><stem cells><systemic inflammation><systemic inflammatory response><tool><whole genome>
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Miler T. S. Lee

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$425,953
FY 2026

Project Title

Transcriptome reprogramming in the early embryo

Grant Number:

2R35GM137973-06

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/24/2020

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Animals are composed of many different cell types that perform specialized functions, which arise from their specific gene expression programs. These differentiated cells all originated from less specialized stem cells, which in turn originated from a special population of “pluripotent” embryonic st...

Research Terms

<3-D><3-Dimensional><3D><Acceleration><Address><Animals><Assay><Binding><Bioassay><Biogenesis><Biological Assay><Brachydanio rerio><Cancers><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cells><Chromatin><Chromosomes><DNA><Danio rerio><Deoxyribonucleic Acid><Development><Disease><Disorder><Distal><ES cell><Embryo><Embryonic><Enhancers><Enzyme Gene><Enzymes><Fertilization><Gene Expression><Gene Transcription><Genes><Genetic><Genetic Transcription><Genome><Goals><Histones><Human><Induced pluripotency><Induced pluripotent state><Intracellular Communication and Signaling><Link><Logic><Malignant Neoplasms><Malignant Tumor><Maps><Modern Man><Molecular><Molecular Interaction><Origin of Life><Pattern><Pluripotent Stem Cells><Progenitor Cells><RNA Expression><Regulation><Regulatory Element><Repression><Science><Signal Transduction><Signal Transduction Systems><Signaling><Special Population><Stem Cell like><Technology><Transcription><Transcription Activation><Transcriptional Activation><Zebra Danio><Zebra Fish><Zebrafish><biological signal transduction><cell type><cellular differentiation><developmental><disease model><disorder model><egg><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><fertilizations><genome scale><genome-wide><genomewide><global gene expression><global transcription profile><histone modification><histone-binding proteins><improved><loss of function><malignancy><neoplasm/cancer><novel><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pluripotent progenitor><progenitor capacity><progenitor cell like><progenitor-like><programs><stem><stem cell characteristics><stem cell of embryonic origin><stem cells><stem-like><stemness><three dimensional><transcriptome><zebrafish development>
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Juliet Girard

UNIVERSITY OF MASSACHUSETTS BOSTON, BOSTON, MA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$425,333
FY 2026

Project Title

Cellular and molecular mechanisms of stem and progenitor cell development during homeostasis and after injury

Grant Number:

1R35GM162263-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract: Tissue homeostasis requires the precise control of the development of differentiated cell types from multipotent stem and progenitor cells (SPCs). This balance is regulated by signals originating from multi-tissue niches or SPCs themselves, which affect SPC development. Inc...

Research Terms

<ASCVD><Address><Adult-Onset Diabetes Mellitus><Affect><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Autoregulation><Blood><Blood Reticuloendothelial System><Body System><Body Tissues><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Data><Development><Developmental Process><Disease><Disorder><Distant><Drosophila melanogaster><Dysfunction><Equilibrium><Functional disorder><Goals><Homeostasis><Inflammatory><Injury><Intracellular Communication and Signaling><Ketosis-Resistant Diabetes Mellitus><Maturity-Onset Diabetes Mellitus><Modeling><Molecular><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Organ System><Pathway interactions><Phenotype><Physiological Homeostasis><Physiopathology><Progenitor Cells><Research><Role><Signal Pathway><Signal Transduction><Signal Transduction Pathway><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Stem Cell Development><System><T2 DM><T2D><T2DM><Tissues><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Wound Repair><adult onset diabetes><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><balance><balance function><biological signal transduction><cell type><cellular differentiation><developmental><human disease><injuries><insight><ketosis resistant diabetes><knock-out animal><knockout animal><maturity onset diabetes><multipotency><multipotent><pathophysiology><pathway><prevent><preventing><progenitor biology><progenitor cell biology><progenitor cell development><progenitor cell differentiation><progenitor cell maintenance><progenitor cell niche><progenitor development><progenitor differentiation><progenitor maintenance><progenitor niche><programs><social role><stem><stem and progenitor biology><stem and progenitor cell development><stem and progenitor cell niche><stem and progenitor differentiation><stem cell biology><stem cell differentiation><stem cell maintenance><stem cell niche><stem cells><type 2 DM><type II DM><type two diabetes><wound healing><wound recovery><wound resolution>
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Sandra Pinho

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$423,097
FY 2026

Project Title

Mechanisms of hematopoietic stem cell engraftment

Grant Number:

5R01HL162584-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Hematopoietic stem cells (HSCs) possess the ability to replenish a new functional hematopoietic system in recipients following transplantation and are the only curative treatment for many hematopoietic malignancies and disorders. However, the availability of donor human leu...

Research Terms

<Adhesion Molecule><Allogeneic Transplantation><Allogenic><Allografting><Assay><Automobile Driving><Bioassay><Biological Assay><Blood Precursor Cell><Bone Marrow><Bone Marrow Grafting><Bone Marrow Reticuloendothelial System><Bone Marrow Transplant><Bone Marrow Transplantation><CD106><CD106 Antigens><CD49d-CD29><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clinical><Cytometry><Data><Defect><Disease><Disorder><Dose><Eating><Endothelial Cells><Engineering><Engraftment><Failure><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Food Intake><Gene Transcription><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><Goals><Graft Rejection><HL-A Antigens><HLA Antigens><HSC niche><HSC transplantation><Haplotypes><Hematologic Body System><Hematologic Organ System><Hematopoietic><Hematopoietic Body System><Hematopoietic Cell Tumor><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic System><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Hematopoietic stem cells><Histocompatibility><Histocompatibility Complex><Histocompatibility Complices><Homing><Homologous Transplantation><Human><Human Leukocyte Antigens><INCAM-110><Immune><Immune Evasion><Immune Precipitation><Immune Tolerance><Immune response><Immunes><Immunochemical Immunologic><Immunologic><Immunologic Tolerance><Immunological><Immunologically><Immunologics><Immunomodulation><Immunoprecipitation><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><In Vitro><Inducible Cell Adhesion Molecule 110><Innate Immune Response><Innate Immune System><Integrin Heterodimer alpha4beta1><Integrin alpha(4)beta(1)><Integrin alpha4beta1><Integrin α4β1><Intracellular Communication and Signaling><Leukocyte Antigens><Life><Major Histocompatibility Complex><Major Histocompatibility Complices><Malignant><Malignant - descriptor><Malignant Hematopoietic Neoplasm><Marrow Transplantation><Mediating><Mice><Mice Mammals><Modern Man><Molecular><Molecular Target><Murine><Mus><Myelogenous><Myeloid><Myeloid Cells><Non-Malignant><Pathway interactions><Patients><Phagocytes><Phagocytic Cell><Phagocytosis><Progenitor Cell Engraftment><Progenitor Cell Transplantation><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Recombinant DNA Technology><Recovery><Role><Series><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell Transplantation><Stem cell transplant><Stromal Cells><Testing><Tissue Compatibility><Transcription><Transplant Rejection><Transplantation><Transplantation Rejection><VCAM><VCAM-1><VLA-4><Vascular Cell Adhesion Molecule><Vascular Cell Adhesion Molecule-1><Very Late Activation Antigen-4><Very Late Antigen-4><adaptive immune response><amebocyte><biological signal transduction><blood cancer><blood cell progenitor><blood progenitor><blood stem cell><blood stem cell niche><blood stem cell transplantation><blood-forming stem cell><cancer of blood><cancer of the blood><cell adhesion protein><cell type><curative intervention><curative therapeutic><curative therapy><curative treatments><donor progenitor><donor progenitor cell><donor stem cell><driving><flow cytophotometry><genetically engineered><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic progenitor niche><hematopoietic stem cell niche><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><host response><immune evasive><immune modulation><immune regulation><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immune system tolerance><immune unresponsiveness><immunologic reactivity control><immunological paralysis><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved><improved outcome><in vivo><in vivo engraftment><innate check point><innate checkpoint><innate immune check point><innate immune checkpoint><innate immune function><innate immunity checkpoint><innovate><innovation><innovative><insight><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><nonmalignant><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><pathway><prevent><preventing><progenitor transplantation><receptor><response><social role><stem and progenitor cell transplantations><stem cell engraftment><success><transcriptome sequencing><transcriptomic sequencing><transplant><transplant model>
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CHRISTIAN SELL

DREXEL UNIVERSITY, PHILADELPHIA, PA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$416,856
FY 2026

Project Title

Novel longevity enhancing pathways regulated by mTOR

Grant Number:

5R01AG071815-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT/SUMMARY Inhibitors of the mTOR pathway are among the most promising interventions to target age-related dysfunction, however, there is a critical need to further define the pro longevity effects to facilitate clinical development of mTOR inhibitors. The current proposal will significantly a...

Research Terms

<AD dementia><ASM1><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Antioncogene Protein p53><Body Tissues><Breeding><CCCTC-binding factor><CDK4I><CDKN2><CDKN2 Genes><CDKN2A><CDKN2A gene><CMM2><CTCF protein><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Senescence><Cell Signaling><Cells><Cellular Aging><Cellular Immune Function><Cellular Senescence><Cellular Tumor Antigen P53><Clinical><Complex><Cyclin-Dependent Kinase Inhibitor 2A Gene><Cytoplasm><D11S813E><DNA-binding protein CTCF><Data><Development><Disease><Disorder><Drug usage><Dysfunction><ENX-1><EZH1><EZH2><EZH2 gene><Elderly><Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Family><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Functional RNA><Functional disorder><Gene Down-Regulation><Gene Transcription><Genetic Transcription><Goals><Grant><H19><H19 gene><Heart failure><Human><INK4><INK4A><Increase lifespan><Inflammation><Intervention><Intracellular Communication and Signaling><KMT6><KMT6A><Kinases><Laboratories><Length of Life><Longevity><MGC4485><MTS1><MTS1 Genes><Maintenance><Mechanistic Target of Rapamycin><Mediating><Mediator><Metabolic><Mice><Mice Mammals><MicroRNAs><Modeling><Modern Man><Monitor><Murine><Mus><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Oncoprotein p53><P53><Pathway interactions><Phosphoprotein P53><Phosphoprotein pp53><Phosphotransferase Gene><Phosphotransferases><Physiopathology><Play><Primary Senile Degenerative Dementia><Promoter Regions><Promotor Regions><Protein TP53><RAFT1><RNA><RNA Expression><RNA Gene Products><Rapamune><Rapamycin><Regulation><Replicative Senescence><Reporter><Research><Ribonucleic Acid><Role><Signal Transduction><Signal Transduction Systems><Signaling><Sirolimus><Somatic Cell><TP16><TP53><TP53 gene><TRP53><TSG9A><Testing><Tissues><Transcription><Transcription Repression><Transphosphorylases><Tumor Protein p53><Tumor Protein p53 Gene><Untranslated RNA><Work><Zinc Finger Domain><Zinc Finger Motifs><Zinc Fingers><adult progenitor><adult stem cell><advanced age><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age reversal><age specific><age-related disease><age-related disorder><age-related impairment><aging reversal><alleviate age related><alleviate aging><ameliorating aging><attenuation of senescence><biological signal transduction><boost longevity><cardiac failure><cell type><chromatin modification><clinical development><counter age related><counter aging><counteract age related><counteract aging><decrease senescence><delay senescence><developmental><drug use><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><foster longevity><gene repression><genetic promoter element><genetic promoter sequence><geriatric><healthy aging><healthy human aging><immune function><improve lifespan><improve longevity><improved><in vivo><individual response><individualized response><inhibitor><late in life><late life><lifespan extension><mTOR><mTOR Inhibitor><mTOR inhibition><mammalian target of rapamycin><member><miRNA><new marker><noncoding><novel><novel biomarker><novel marker><p14ARF><p16 Genes><p16INK4 Genes><p16INK4A Genes><p16INK4a><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pathophysiology><pathway><pluripotency><pluripotent state><prevent><preventing><primary degenerative dementia><progenitor cell function><progenitor cell pool><progenitor cell population><progenitor function><progenitor pool><progenitor population><programs><prolong lifespan><prolong longevity><promote lifespan><promote longevity><promoter><promoter sequence><promotor><protein p53><reduce senescence><reducing cellular senescence><replicative aging><repress senescence><response><reverse age><reverse aging><reverse aging effects><reversible aging><senescence><senescence mitigation><senescent><senescent cell><senile dementia of the Alzheimer type><senior citizen><side effect><social role><somatic progenitor><somatic stem cell><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor function><stem cell function><stem cell pool><stem cell population><support longevity><suppress senescence><tissue progenitor><tissue specific progenitor cells><tissue specific stem cells><tissue stem cells>
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TROY A MARKEL

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$415,582
FY 2026

Project Title

Sulfur Based Stem Cell Therapeutics in Necrotizing Enterocolitis

Grant Number:

5R01DK133418-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

This investigator's proposal describes a 5-year project designed to study mesenchymal stem cells derived from inducible pluripotent stem cells as a treatment modality for necrotizing enterocolitis (NEC). NEC is a devastating intrabdominal emergency in the neonatal population that often requires the ...

Research Terms

<Abdomen><Abscission><Angiogenesis Modulating Agents><Angiogenesis Modulators><Animals><Apoptosis><Apoptosis Pathway><Assay><Award><Bioassay><Biological Assay><Blood flow><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Culture System><Cell Growth in Number><Cell Locomotion><Cell Migration><Cell Movement><Cell Multiplication><Cell Proliferation><Cell Signaling><Cell Therapy><Cells><Cellular Migration><Cellular Motility><Cellular Proliferation><Cessation of life><Childhood><Clinical><Clinical Trials><Collaborations><DNA mutation><Death><Death Rate><Degenerative Arthritis><Degenerative polyarthritis><Detection><Development><Diabetic Foot Ulcer><ENOS><Emergencies><Emergency Situation><Endogenous Nitrate Vasodilator><Endothelial Nitric Oxide Synthase><Endothelium><Endothelium-Derived Nitric Oxide><Enzyme Gene><Enzyme Precursors><Enzymes><Equilibrium><Esters><Evaluation><Excision><Exhibits><Extirpation><Funding><GI microbiome><Gases><Generations><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Grant><Gut Mucosa><GvHD><Harvest><Homologous Wasting Disease><Human><Hydrogen Sulfide><Hypoxia><Hypoxic><IND Filing><IND application><IND package><IND submission><Immune><Immunes><In Situ><In Vitro><Infant><Inflammatory Response><Infrastructure><Infusion><Infusion procedures><Institution><International><Intestinal><Intestines><Intra-abdominal><Intracellular Communication and Signaling><Investigational New Drug Application><Investigators><Ischemia><Laboratories><Length><Measures><Mediating><Mediator><Medical><Medical Care Costs><Mentors><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mesenteric><Mesentery><Methods><Mice><Mice Mammals><Modality><Modeling><Modern Man><Mononitrogen Monoxide><Murine><Mus><Mutation><Myography><NIDDK><NOS3><NOS3 gene><National Institute of Diabetes and Digestive and Kidney Diseases><Necrosis><Necrotic><Necrotizing Enterocolitis><Neonatal><Nitric Oxide><Nitric Oxide Synthase 3><Nitrogen Monoxide><Nitrogen Protoxide><Nutrition><Operative Procedures><Operative Surgical Procedures><Osteoarthritis><Osteoarthrosis><Outcome><Oxygen Deficiency><Patients><Phase><Population><Preclinical data><Premature Infant><Production><Proenzymes><Progenitor Cells><Programmed Cell Death><Property><Quality Control><Recovery><Removal><Research><Research Personnel><Researchers><Role><Runt Disease><S element><Safety><Scientist><Sepsis><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Source><Stress><Sulfur><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><System><Testing><Therapeutic Effect><Tissues><Transgenic Mice><Transplantation><Type III nitric oxide synthase><Tyrosine><Universities><Vasodilatation><Vasodilation><Vasorelaxation><Veterinarians><Volatilization><Zymogens><absorption><balance><balance function><biological signal transduction><biological systems><bowel><career><cell based intervention><cell mediated intervention><cell mediated therapies><cell motility><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><cost><critical limb Ischemia><degenerative joint disease><design><designing><detection method><detection procedure><detection technique><developmental><diabetic foot wound><digestive tract microbiome><endothelial cell derived relaxing factor><enteric microbiome><experiment><experimental research><experimental study><experiments><gastrointestinal microbiome><genome mutation><graft versus host disease><graft vs host disease><graft vs. host disease><gut microbiome><gut-associated microbiome><hypertrophic arthritis><iPS><iPSC><iPSCs><immunogenicity><improved><in vivo><in vivo Model><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infants born premature><infants born prematurely><infusions><injury to the intestines><innovate><innovation><innovative><intestinal biome><intestinal injury><intestinal microbiome><medical costs><medical expenses><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><minimally invasive><mortality rate><nano-molar><nanomolar><novel><overexpress><overexpression><paracrine><pediatric><pig model><piglet model><polysulfide><porcine model><preclinical findings><preclinical information><premature><premature baby><premature infant human><prematurity><pressure><preterm baby><preterm infant><preterm infant human><progenitor cell based therapy><progenitor cell therapy><progenitor cell treatment><progenitor therapy><progenitor treatment><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><resection><social role><stem and progenitor cell therapy><stem cell based therapy><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><surgery><swine model><systemic inflammation><systemic inflammatory response><therapeutically effective><transplant>
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Josephina C van Wolfswinkel

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$399,529
FY 2026

Project Title

Role of transposon regulation in the negligible senescence of S. mediterranea

Grant Number:

5R01AG078926-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY The progressive decline in the function of adult stem cells is a major factor in the development of age-related conditions. Considering the increasing age of the overall human population, identifying strategies to prolong stem cell health is of major importance. Study of short-lived ...

Research Terms

<21+ years old><ATAC sequencing><ATAC-seq><ATACseq><Acceleration><Address><Adult><Adult Human><Affect><Age><Aging><Animals><Appearance><Assay for Transposase-Accessible Chromatin using sequencing><Attention><Biologic Models><Biological Models><Biology of Aging><Body Tissues><Cell Body><Cell Differentiation><Cell Differentiation process><Cells><Chemicals><Chromatin><Complex><DNA Transposable Elements><Development><Dysfunction><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Functional disorder><Genomics><Goals><Health><Health Care Systems><Human><Life><Maintenance><Measures><Mediating><Mobile Genetic Elements><Model System><Modern Man><Molecular><Non-Polyadenylated RNA><Pathway interactions><Phenotype><Physiopathology><Planarians><Play><Population><Post-Transcriptional Gene Silencing><Process><Progenitor Cells><Proteins><RNA><RNA Gene Products><RNA Interference><RNA Seq><RNA Silencing><RNA sequencing><RNAi><RNAseq><Regulation><Repression><Research Specimen><Resistance><Ribonucleic Acid><Role><Sequence-Specific Posttranscriptional Gene Silencing><Specimen><Stereotyping><System><Time><Tissue Differentiation><Tissues><Transposable Elements><Work><accelerated aging><accelerated biological age><accelerated biological aging><adult progenitor><adult stem cell><adulthood><age acceleration><age associated><age associated alterations><age associated biomarkers><age associated changes><age associated marker><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age linked><age marker><age related><age related alterations><age related biomarkers><age related changes><age related markers><age reversal><age specific><age specific alterations><age specific changes><aged><ages><aging associated alterations><aging associated changes><aging biological marker><aging biomarker><aging correlated alterations><aging correlated changes><aging delay><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging marker><aging related alterations><aging related changes><aging reversal><aging specific alterations><aging specific changes><alleviate age related><alleviate aging><alterations with age><ameliorating aging><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><attenuate aging><biological markers of age><biomarkers of age><cell age><cellular age><cellular differentiation><changes with age><chromatin modification><cost><counter age related><counter aging><counteract age related><counteract aging><decelerate aging><decline in function><decline in functional status><delay age related><derepression><developmental><driving force><epigenetically><functional decline><functional status decline><gene locus><genetic locus><genomic location><genomic locus><healthspan><healthy life span><human progenitor><human stem cells><improved><in vivo><insight><life span><lifespan><mortality><pace of aging><pace of biological aging><pathophysiology><pathway><pause aging><piRNA><piwi RNA><postpone age related><progenitor aging><progenitor cell aging><progenitor cell maintenance><progenitor cell pool><progenitor cell population><progenitor maintenance><progenitor pool><progenitor population><rate of aging><rate of biological aging><rate of change><regenerative><regenerative tissue><resistant><retards aging><reverse age><reverse aging><reverse aging effects><reversible aging><senescence><senescent><slow aging><slow down aging><slow the rate of aging><social role><somatic progenitor><somatic stem cell><speed of aging><speed of the aging><stem and progenitor cell population><stem cell aging><stem cell maintenance><stem cell pool><stem cell population><stem cells><transcriptome sequencing><transcriptomic sequencing>
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Daniel McIntyre

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$395,698
FY 2026

Project Title

How the structural complexity of the niche enables stem cell function during development and homeostatsis

Grant Number:

1R35GM161604-01

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT In the developing embryo, in adult tissues such as the skin and intestine, and in many types of cancer, stem cells exist in close association with a supporting niche. The importance of the niche cannot be overstated. It both regulates stem cells’ ability to self-renew and co...

Research Terms

<21+ years old><Adhesives><Adult><Adult Human><Animals><Automobile Driving><Basement membrane><Biochemical><Body Tissues><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Survival><Cell Viability><Cell-Extracellular Matrix><Cells><Development><Disease><Disorder><ECM><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Environment><Exclusion><Extracellular Matrix><Genetic><Germ Lines><Goals><Health><Human><Intestinal><Intestines><Intracellular Communication and Signaling><Knowledge><Membrane><Membrane Structure and Function><Modeling><Modern Man><Process><Progenitor Cells><Proliferating><Regulation><Research><Resting progenitor><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Structure><Surface><System><Tissues><adult animal><adulthood><biological signal transduction><bowel><cancer type><cell behavior><cellular behavior><developmental><dormant stem cell><driving><experience><germ stem cells><germline progenitor><germline progenitor cells><germline stem cells><imaging in vivo><in vivo imaging><inactive stem cell><insight><latent progenitor><latent stem cell><mature animal><mechanical cue><mechanical properties><mechanical signal><membrane structure><progenitor biology><progenitor cell biology><progenitor cell function><progenitor cell niche><progenitor function><progenitor niche><programs><quiescent progenitor><quiescent stem cells><resting stem cell><self-renew><self-renewal><stem and progenitor biology><stem and progenitor cell function><stem and progenitor cell niche><stem and progenitor function><stem cell biology><stem cell function><stem cell niche><stem cell quiescence><stem cells><stem cells in the germline><tool>
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Elizabeth Diana Kirby

OHIO STATE UNIVERSITY, Columbus, OH

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$382,277
FY 2026

Project Title

Regulation of adult hippocampal function by the neural stem and progenitor cell secretome

Grant Number:

5R01NS124775-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/23/2021

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

A unique neurogenic niche in the adult hippocampus hosts neural-lineage stem cells that can persist throughout the lifespan in a wide range of adult mammals. Uncovering the functional role of these stem cells and how they interact with other cell types in the niche can provide insight in to the mech...

Research Terms

<21+ years old><Acquired brain injury><Acute><Adult><Adult Human><Affect><Amino Acids><Ammon Horn><Astrocytes><Astrocytus><Astroglia><Autocrine Systems><Autoregulation><Behavioral><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Injuries><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cognitive><Collection><Cornu Ammonis><Coupled><Cytoplasmic Granules><Data><Dentate Fascia><Dimensions><Disease><Disorder><Dysfunction><Emotions><Encephalon><Encephalon Diseases><Exposure to><Fascia Dentata><Functional disorder><Gatekeeping><Genetic Code><Goals><Growth Agents><Growth Factor><Growth Substances><Gyrus Dentatus><Gyrus Hippocampi><Gyrus Parahippocampalis><Health><Hippocampal Gyrus><Hippocampus><Homeostasis><Impairment><Individual><Influentials><Injury><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Isoforms><Literature><Mammalia><Mammals><Mediating><Memory><Modeling><Natural regeneration><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurons><Neurophysiology - biologic function><Parahippocampal Gyrus><Pattern><Physiological Homeostasis><Physiology><Physiopathology><Population><Process><Production><Progenitor Cells><Protein Isoforms><Protein Secretion><Proteins><Proteins Growth Factors><Recovery><Regeneration><Regulation><Reporting><Research><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Source><Testing><Therapeutic><Time><Tissues><Transgenic Organisms><Undifferentiated><VEGF><VEGFs><Vascular Endothelial Growth Factors><Work><adult neurogenesis><adulthood><aminoacid><astrocytic glia><autocrine><behavior response><behavioral response><biological signal transduction><brain damage><brain health><brain-injured><cell type><cytokine><dentate gyrus><emotion regulation><emotional functioning><emotional regulation><excitotoxic><excitotoxicity><experiment><experimental research><experimental study><experiments><functional improvement><gatekeeper><granule><hippocampal><improve function><improved functional outcomes><indexing><injuries><injury response><insight><knock-down><knockdown><life span><lifespan><nerve stem cell><neural><neural function><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><paracrine><pathophysiology><pleiotropic effect><pleiotropism><pleiotropy><progenitor><progenitor and neural stem cells><progenitor cell proliferation><progenitor proliferation><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><response to injury><social role><source localization><stem><stem and progenitor cell proliferation><stem cell proliferation><stem cells><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transgenic><viral rescue>
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Munjal M Acharya

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$359,138
FY 2026

Project Title

Stem cell-derived exosomes to ameliorate chemobrain

Grant Number:

5R01CA262213-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/13/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT Numerous clinical and preclinical studies have established the debilitating neurocognitive side effects of various chemotherapy regimens for the treatment of cancer, often referred as chemobrain. With substantial increases in the number of cancer survivors, over 16.9 million in the U.S. alo...

Research Terms

<14-Hydroxydaunomycin><21+ years old><Adjuvant Chemotherapy><Adjuvant Drug Therapy><Adriablastin><Adriablastine><Adriacin><Adriamycin PFS><Adriamycin RDS><Adriamycine><Adriblastin><Adriblastina><Adriblastine><Adrimedac><Adult><Adult Human><Ammon Horn><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Animals><Anzatax><Architecture><Asotax><Behavioral><Brain><Brain Nervous System><Breast Cancer><Bristaxol><CBDCA><CDDP><CTX><CYCLO-cell><Cancer Model><Cancer Survivor><Cancer Treatment><CancerModel><Cancers><Carboplatin><Carboplatino><Caring><Carloxan><Cell Communication and Signaling><Cell Signaling><Chemotherapy Protocol><Chemotherapy Regimen><Chemotherapy-Oncologic Procedure><Chronic><Ciclofosfamida><Ciclofosfamide><Cicloxal><Cis-diammine-dichloroplatinum><Cis-diamminedichloridoplatinum><Cis-diamminedichloro Platinum (II)><Cis-dichloroammine Platinum (II)><Cis-platinous Diamine Dichloride><Cis-platinum II><Cis-platinum II Diamine Dichloride><Cisplatin><Cisplatina><Cisplatinum><Clafen><Claphene><Clinical><Clinical Data><Clinical Research><Clinical Study><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Combination Chemotherapy Regimen><Cornu Ammonis><Cranial Irradiation><Cycloblastin><Cycloblastine><Cyclophospham><Cyclophosphamide><Cyclophosphamidum><Cyclophosphan><Cyclophosphane><Cyclophosphanum><Cyclostin><Cyclostine><Cysplatyna><Cytophosphan><Cytophosphane><Cytoxan><DOXO-CELL><Data><Degenerative Neurologic Disorders><Dichlorodiammineplatinum><Disease><Disorder><Disturbance in cognition><Doxolem><Doxorubicin><Doxorubicina><Doxorubin><Drug Kinetics><Dysfunction><Effectiveness><Emotional><Encephalon><Endoxan><Endoxana><Enduxan><Engineering / Architecture><Farmiblastina><Fosfaseron><Foundations><Functional disorder><Gene Targeting><Generalized Growth><Genes><Genoxal><Genuxal><Growth><Heterograft><Heterologous Transplantation><Hippocampus><Human><Hydroxyl Daunorubicin><Hydroxyldaunorubicin><Iatrogenic Cancer><Impaired cognition><Impairment><In Vitro><Incidence><Inflammation><Inflammatory><Injections><Intracellular Communication and Signaling><Intravenous><Ledoxina><Liposomal Adriamycin><Malignant Breast Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Ovarian Neoplasm><Malignant Ovarian Tumor><Malignant Tumor><Malignant Tumor of the Ovary><Malignant neoplasm of ovary><Mediating><Mice><Mice Mammals><MicroRNAs><Mitoxan><Modeling><Modern Man><Molecular><Murine><Mus><Neosar><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural Stem Cell><Neural degenerative Disorders><Neurobiology><Neurocognitive><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurons><Ovary Cancer><Paclitaxel><Paclitaxel (Taxol)><Pathologic><Patients><Performance><Peyrone's Chloride><Peyrone's Salt><Pharmacokinetics><Physiopathology><Platinum Diamminodichloride><Play><Praxel><Preclinical data><Procytox><Progenitor Cells><Publishing><QOL><Quality of life><Quimioterapia><Radiation therapy><Radiotherapeutics><Radiotherapy><Regimen><Research Design><Role><Rubex><Safety><Sendoxan><Series><Signal Transduction><Signal Transduction Systems><Signaling><Spinal Column><Spine><Structure><Study Type><Survivors><Syklofosfamid><Synapses><Synaptic><Taxol><Taxol A><Taxol Konzentrat><Testing><Therapeutic><Therapy Related Malignant Neoplasm><Therapy Related Malignant Tumor><Therapy-Associated Cancers><Therapy-Related Cancer><Tissue Growth><Toxic effect><Toxicities><Transgenic Mice><Translating><Transplantation><Treatment-Associated Cancer><Treatment-Related Cancer><Validation><Veins><Vertebral column><Xenograft><Xenograft procedure><Xenotransplantation><Zytoxan><adriamycin><adulthood><amygdaloid nuclear complex><anti-cancer therapy><backbone><biological signal transduction><brain irradiation><brain radiation><cancer chemotherapy><cancer therapy><cancer-directed therapy><candidate identification><care giver stress><caregiver distress><caregiver stress><chemo-/radio-therapy><chemo-induced cognitive decline><chemo-radiotherapy><chemobrain><chemoradiation><chemoradiation therapy><chemoradiation treatment><chemoradiotherapy><chemotherapy><chemotherapy-associated cognitive impairment><chemotherapy-induced cognitive decline><chemotherapy-induced cognitive dysfunction><chemotherapy-induced cognitive impairment><chemotherapy-related cognitive decline><chemotherapy-related cognitive dysfunction><chemotherapy-related cognitive impairment><cis dichlorodiammineplatinum><cis platinum compound><cis-Diaminedichloroplatinum><cis-Diamminedichloroplatinum><cis-Diamminedichloroplatinum(II)><cis-Dichlorodiammineplatinum(II)><cis-Platinum><cognitive defects><cognitive dysfunction><cognitive function><cognitive impairment due to chemotherapy><cognitive loss><cognitive task><coping><cranial radiation><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><density><effectiveness testing><extracellular vesicles><frontal cortex><frontal lobe><hippocampal><improved><in vivo><intervention design><irradiation><malignancy><malignant breast tumor><medial temporal area><medial temporal lobe><mesial temporal area><mesial temporal lobe><miRNA><mouse model><murine model><neoplasm/cancer><nerve cell death><nerve cell loss><nerve stem cell><neural inflammation><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurobiological><neurodegenerative illness><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuroinflammation><neuroinflammatory><neuron cell death><neuron cell loss><neuron death><neuron loss><neuron progenitors><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal loss><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><neuroprotection><neuroprotective><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><ovarian cancer><pathophysiology><post-chemotherapy cognitive impairment><pre-clinical study><preclinical findings><preclinical information><preclinical study><prevent><preventing><progenitor and neural stem cells><progenitor derived exosomes><progenitor exosomes><protein expression><radiation treatment><radio-chemo-therapy><radio-chemotherapy><radiochemotherapy><regenerative approach><regenerative strategy><regenerative technique><response><safety testing><side effect><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><stem cell derived exosomes><stem cell exosomes><stem cells><stress among caregiver><stress in caregiver><stress on caregiver><study design><synapse><therapeutic outcome><therapy design><therapy outcome><transplant><treatment design><treatment with radiation><validations><xeno-transplant><xeno-transplantation>
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Alexander Matthew Holtz

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$167,940
FY 2026

Project Title

Endothelial cell-based therapy for pulmonary vascular disease using induced pluripotent stem cells

Grant Number:

5K08HL173561-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/20/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The following proposal outlines a 5-year career training plan that will prepare Dr. Alexander Holtz to be an independent physician-scientist and leader in the field of induced pluripotent stem cell (iPSC) biology and cellular therapies for pulmonary vascular disorders. Pulmonary vasc...

Research Terms

<ACD/MPV><ACDMPV><ACVRL1><ACVRL1 gene><ACVRLK1><ALK-1><Activin A Receptor, Type II-Like Kinase 1 Gene><Activin Receptor-Like Kinase 1 Gene><Activities of Daily Living><Activities of everyday life><Affect><Alveolar capillary dysplasia with misalignment of pulmonary veins><Assay><Autologous><Award><BMPR-II><BMPR2><BMPR2 gene><BRK-3 protein><Bioassay><Biological Assay><Blood Precursor Cell><Blood Vessels><Body Tissues><Bone Morphogenetic Protein Receptor, Type II (Serine/Threonine Kinase) Gene><Boston><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Growth in Number><Cell Multiplication><Cell Physiology><Cell Process><Cell Proliferation><Cell Signaling><Cell Therapy><Cell Transplantation><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Proliferation><Cellular biology><Children's Hospital><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><DNA mutation><Data><Defect><Development><Disease><Disorder><Dysfunction><Embryo><Embryonic><Endothelial Cells><Endothelium><Engraftment><Expression Signature><FKHL5><FOXF1><FOXF1 gene><FREAC1><Forkhead Box F1><Forkhead, Drosophila, Homolog-Like 5><Forkhead-Related Activator 1><Frustration><Functional disorder><Gene Alteration><Gene Expression Profile><Gene Mutation><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genomics><Goals><Grant><HHT2><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterogeneity><Human><Hyperoxia><Immunocompetent><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Immunosuppressed Host><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Individual><Injury><Institution><Integral Membrane Protein><Intracellular Communication and Signaling><Intrinsic Membrane Protein><Label><Length of Life><Longevity><Luciferase Immunologic><Luciferases><Lung><Lung Respiratory System><Lung damage><Manuscripts><Measures><Mediating><Medical center><Mentors><Mice><Mice Mammals><Modern Man><Molecular Fingerprinting><Molecular Profiling><Morbidity><Murine><Mus><Mutation><ORW2><Organ><Pathogenesis><Pathogenicity><Pathology><Patients><Pattern><Pediatric Hospitals><Physicians><Physiopathology><Population><Position><Positioning Attribute><Pre-Clinical Model><Preclinical Models><Preparation><Process><Pulmonary Hypertension><Receptor Protein><Regenerative Medicine><Replacement Therapy><Reporter><Research><Role><SKR3><Scientist><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Syndrome><System><Testing><Time><Tissues><Training><Transmembrane Protein><Transmembrane Protein Gene><Transplantation><Universities><Variant><Variation><Work><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><bone morphogenetic protein receptor II><bone morphogenetic protein receptor type II><career><career development><cell based intervention><cell biology><cell mediated intervention><cell mediated therapies><cell replacement therapy><cell replacement treatment><cell-based therapeutic><cell-based therapy><cellular differentiation><cellular therapeutic><cellular therapy><cellular transplant><daily living function><daily living functionality><developmental><directed differentiation><disease model><disorder model><efficacy testing><fitness><fluorophore><functional ability><functional capacity><gene corrected><gene correction><gene defect><gene expression pattern><gene expression signature><genome mutation><genomic correction><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><hyperoxygenation><iPS><iPS biology><iPSC><iPSC biology><iPSCs><immune competent><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressed patient><immunosuppressive activity><immunosuppressive function><immunosuppressive response><impaired pulmonary vascularization><in vivo monitoring><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell biology><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><inducible pluripotent cell><inducible pluripotent stem cell><injuries><lung injury><lung vascular disease><meeting><meetings><molecular phenotype><molecular profile><molecular signature><mortality><mouse model><murine model><mutant allele><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><notch><notch protein><notch receptors><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><pathophysiology><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient-derived pluripotent stem cells><preparations><progenitor><progenitor cell based therapy><progenitor cell function><progenitor cell therapy><progenitor cell treatment><progenitor function><progenitor therapy><progenitor treatment><pulmonary><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><pulmonary vascular disease><pulmonary vascular disorder><pulmonary vascular dysfunction><pulmonary vasculopathy><receptor><reconstitute><reconstitution><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell function><stem and progenitor cell therapy><stem and progenitor function><stem cell based therapy><stem cell function><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><transcriptional profile><transcriptional signature><translational opportunities><translational potential><transplant><transplant model><type II BMP receptor><vascular><vasculogenesis>
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Diana Sa da Bandeira

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$140,809
FY 2026

Project Title

Comparative vertebrate neural crest contribution to the hematopoietic stem cell specification niche

Grant Number:

1K99HL183751-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/10/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Hematopoietic stem cells (HSCs) sustain blood production throughout an organism’s lifetime. They are clinically significant as the key therapeutic component of bone marrow transplants for treating a multitude of hematological and non-hematological disorders. However, HSC transplantat...

Research Terms

<Ablation><Actin-Activated ATPase><Allogenic><Animals><Aorta><Architecture><Autologous><Biological><Biological Function><Biological Process><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Body Tissues><Bone Marrow Grafting><Bone Marrow Transplant><Bone Marrow Transplantation><Brachydanio rerio><Catecholamines><Cell Body><Cell Communication and Signaling><Cell Locomotion><Cell Maturation><Cell Migration><Cell Movement><Cell Signaling><Cells><Cellular Migration><Cellular Motility><Communication><Complex><Cues><DTR Protein><Danio rerio><Data><Development><Diphtheria Toxin Sensitivity><Disease><Disorder><Dorsal><Drugs><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Endothelial Cells><Endothelium><Engineering / Architecture><Filopodia><Future><Generations><Geography><Goals><Gonadal structure><HB-EGF precursor><HSC Specification><HSC emergence><HSC formation><HSC transplantation><Hb SS disease><HbSS disease><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematology><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Specification><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Imaging technology><In Vitro><Intracellular Communication and Signaling><Investments><Kinetics><Knock-out><Knockout><Laboratories><Leanness><Lineage Tracing><Maintenance><Maps><Marrow Transplantation><Mediating><Medication><Mesonephric structure><Mesonephros><Mice><Mice Mammals><Modeling><Murine><Mus><Myosin ATPase><Myosin Adenosine Triphosphatase><Myosin Adenosinetriphosphatase><Myosins><Nerve Cells><Nerve Unit><Neural Cell><Neural Crest><Neural Crest Cell><Neurocyte><Neurons><Organism><Peptide Signal Sequences><Pharmaceutical Preparations><Phase><Phylogenetic Analysis><Phylogenetics><Population><Process><Production><Role><Sickle Cell Anemia><Signal Peptide><Signal Sequences><Signal Transduction><Signal Transduction Systems><Signaling><Source><Specific qualifier value><Specified><Sympathins><System><Testing><Therapeutic><Therapeutic Uses><Thinness><Time><Tissues><Vertebrate Animals><Vertebrates><Visualization><Wolffian Body><Work><Zebra Danio><Zebra Fish><Zebrafish><biologic><biological signal transduction><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell emergence><blood stem cell formation><blood stem cell transplantation><blood-forming stem cell><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell motility><cellular lineage mapping><cellular lineage tracking><clinical applicability><clinical application><clinical significance><clinically significant><comparative><developmental><differentiation protocol><diphtheria toxin receptor><diptheria toxin receptor><directed differentiation><drug/agent><emergence of hematopoietic stem cells><gonad><gonads><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell formation><hematopoietic progenitor cell transplantation><hematopoietic progenitor formation><hematopoietic stem cell emergence><hematopoietic stem cell formation><hematopoietic stem progenitor cell><hemogenic endothelium><hemopoietic progenitor><hemopoietic stem cell><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><leukemia><leukemia treatment><leukemic therapy><living system><migration><migratory population><mouse model><murine model><neuronal><novel><optogenetics><pre-clinical><preclinical><protein signal sequence><self-renew><self-renewal><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><social role><stem><synthetic enzyme><transplant therapy><transplant treatment><transplantation therapy><transplantation treatment><vertebrata><vertebrate embryos>
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Jelena Mustra Rakic

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$127,168
FY 2026

Project Title

Modeling the Effect of Apolipoprotein LI Risk Variants on CVD Risk in African American E-cigarette Users Using Human Induced Pluripotent Stem-Cell-Derived Endothelial Cells

Grant Number:

1K99HL183741-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT African American individuals face a disproportionately higher risk of tobacco-related cardiovascular diseases (CVD) than other races, a disparity not fully explained by traditional and socioeconomic risk factors. Despite lacking approval from the U.S. Food and Drug Administr...

Research Terms

<(TNF)-α><Address><Adverse effects><African American><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><After Care><After-Treatment><Aftercare><Apolipoproteins><Apoplexy><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Beta Proprotein Interleukin 1><Blood Vessels><Brain Vascular Accident><CCL2><CCL2 gene><CD183><CKR-L2><CMKAR3><CRG-2><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CXCL10><CXCL10 gene><CXCR3><CXCR3 gene><Cachectin><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Models><Cardiovascular Organ System><Cardiovascular system><Cas nuclease technology><Cell Communication and Signaling><Cell Culture Techniques><Cell Function><Cell Line><Cell Physiology><Cell Process><Cell Signaling><CellLine><Cellular Function><Cellular Physiology><Cellular Process><Cellular injury><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chemokine (C-X-C Motif) Receptor 3><Chemokine, CC Motif, Ligand 2><Cigarette><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Communities><Computational Technique><Coronary Disease><Coronary heart disease><Development><Disease><Disease Management><Disorder><Disorder Management><Disparities><Disparity><Dysfunction><Electronic cigarette><Endothelial Cells><Endothelium><Exhibits><Exposure to><Face><Food and Drug Administration><Functional disorder><G Protein-Coupled Receptor 9><GPR9><Gene variant><Genes><Genetic Markers><Genotype><Goals><HPGF><Health><Heart Vascular><Hepatocyte-Stimulating Factor><History><Human><Hybridoma Growth Factor><IFI10><IFN-Gamma><IFN-beta 2><IFN-g><IFN-γ><IFNB2><IFNG><IFNγ><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL-6><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><IL6 Protein><INP10><IP-10><IP10><IP10 Receptor><IP10-Mig receptor><IP10-R><Immune Interferon><Impairment><In Vitro><Inflammation Mediators><Inflammatory><Interferon Gamma><Interferon Type II><Interleukin 1beta><Interleukin-1 beta><Interleukin-1β><Interleukin-6><Intervention><Intracellular Communication and Signaling><Ischemic Stroke><Kidney><Kidney Diseases><Kidney Urinary System><Knowledge><Link><MCAF><MCP-1><MCP1><MGI-2><MOB-1><Macrophage-Derived TNF><Marketing><Menthol><Mentors><Mig Receptor><Mig-R><MigR><Modeling><Modern Man><Molecular><Molecular Target><Monocyte Chemoattractant Protein-1><Monocyte Chemotactic Protein-1><Monocyte Chemotactic and Activating Factor><Monocyte Chemotactic and Activating Protein><Monocyte Chemotactive and Activating Factor><Monocyte Secretory Protein JE><Monocyte-Derived TNF><Myeloid Differentiation-Inducing Protein><Nephropathy><Pathology><Pathway interactions><Pattern><Phase><Phenotype><Physiopathology><Plasmacytoma Growth Factor><Play><Polyunsaturated Fatty Acids><Population><Predisposition><Preinterleukin 1 Beta><Race><Races><Racial Group><Recording of previous events><Renal Disease><Research><Risk><Risk Factors><Risk-associated variant><Role><SCYA2><SCYB10><Safety><Sepsis><Signal Transduction><Signal Transduction Systems><Signaling><Small Inducible Cytokine A2><Smoker><Smoking><Strains Cell Lines><Stroke><Study models><Subcellular Process><Susceptibility><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Tobacco><Tobacco Consumption><Tobacco Industry><Tobacco use><Training><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><USFDA><United States Food and Drug Administration><Variant><Variation><Vascular Endothelial Cell><Work><Youth><Youth 10-21><allelic variant><biological signal transduction><brain attack><burden of disease><burden of illness><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cardiovascular health><cardiovascular injury><cardiovascular risk><cardiovascular risk factor><cell culture><cell cultures><cell damage><cell injury><cellular damage><cerebral vascular accident><cerebrovascular accident><cigarette smoking><cigarette use><cigarette user><circulatory system><clinical relevance><clinically relevant><combustible cigarette><community marginalization><conventional cigarette><coronary disorder><cultured cell line><damage to cells><developmental><disease burden><disparity in health><e-cig><e-cig use><e-cig user><e-cigarette><e-cigarette use><e-cigarette user><ecig><ecig use><ecig user><ecigarette><ecigarette use><ecigarette user><electronic cigarette use><electronic cigarette user><endothelial dysfunction><faces><facial><gIP-10><gene biomarker><gene expression biomarker><gene marker><gene signature biomarker><genetic biomarker><genetic variant><genome editing><genomic editing><genomic variant><health disparity><hiPSC><high risk><high risk group><high risk individual><high risk people><high risk population><histories><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSCs><improved><in vitro Assay><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inflammation marker><inflammatory marker><inflammatory mediator><injury to cells><injury to the vasculature><insight><interest><interferon beta 2><kidney disorder><lFN-Gamma><life-threatening COVID><life-threatening COVID-19><life-threatening SARS-CoV-2><life-threatening coronavirus disease><life-threatening coronavirus disease 2019><life-threatening severe acute respiratory syndrome coronavirus 2><lipid mediator><marginalized community><molecular biomarker><molecular marker><pathophysiology><pathway><post treatment><racial><racial background><racial origin><racial population><racial subgroup><renal><renal disorder><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><serious COVID><serious COVID-19><serious SARS-CoV-2><serious coronavirus disease><serious coronavirus disease 2019><serious severe acute respiratory syndrome coronavirus 2><severe COVID><severe COVID-19><severe COVID19><severe SARS-CoV-2><severe coronavirus disease><severe coronavirus disease 19><severe coronavirus disease 2019><severe severe acute respiratory syndrome coronavirus 2><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><stem cell approach><stem cell based approach><stem cell method><stem cell methodology><stem cell procedure><stem cell technique><stroked><strokes><tobacco company><tobacco product use><tobacco products><traditional cigarette><transcriptomics><trend><vaping><vascular><vascular endothelial dysfunction><vascular injury><youth age>
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Luke William Koblan

WHITEHEAD INSTITUTE FOR BIOMEDICAL RES, CAMBRIDGE, MA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$125,000
FY 2026

Project Title

Spatially-resolved, integrated cell state and lineage tracing to define progenitor cell dynamics in early mouse development

Grant Number:

5K99HD118574-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary: Mammalian development is a probabilistic and robust process where progenitor cells must integrate genetic, epigenetic, and environmental information to generate a complex body plan. The goal of this work is to delineate how progenitor behaviors elicit specific phenotypes in health a...

Research Terms

<3-D><3-Dimensional><3D><Adopted><Affect><Anterior><Atlases><Automobile Driving><Autoregulation><Award><Basal Transcription Factor><Basal transcription factor genes><Basic Research><Basic Science><Behavior><Benchmarking><Best Practice Analysis><Biologic Models><Biological><Biological Models><Biology><Body Tissues><Breast Cancer Model><Breast tumor model><Cancer Biology><Cardiac><Cardiac development><Cell Body><Cell Communication><Cell Function><Cell Interaction><Cell Physiology><Cell Process><Cell-to-Cell Interaction><Cells><Cellular Assay><Cellular Function><Cellular Physiology><Cellular Process><Cessation of life><Characteristics><Collaborations><Complex><DNA editor><Data><Data Analyses><Data Analysis><Data Set><Death><Development><Developmental Biology><Developmental Process><Disease><Disorder><Embryo><Embryologic Structure><Embryonic><Embryonic Structures><Engineering><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Foundations><Future><GEM model><GEMM model><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genetic><Genetic Determinism><Genetic Screening><Genetically Engineered Mouse><Genomic Testing><Genomics><Goals><Growth><Health><High Throughput Assay><History><Homeostasis><Image><In Vitro><Injections><Institution><Investigators><Joints><Knock-in><Lead><Learning><Life><Lineage Tracing><Link><Logic><Maps><Mentors><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Methods><Mice><Mice Mammals><Model System><Modeling><Molecular><Monitor><Mouse ES Cell><Mouse ESC><Mouse Embryonic Progenitor><Mouse Embryonic Stem Cells><Murine><Mus><Neoplasm Metastasis><Normal Cell><Organism><Organogenesis><Outcome><Pattern><Pb element><Phase><Phenotype><Phylogeny><Physiological Homeostasis><Population Sizes><Postdoc><Postdoctoral Fellow><Primary Neoplasm><Primary Tumor><Primitive Streaks><Process><Progenitor Cells><Recording of previous events><Research><Research Associate><Research Personnel><Researchers><Resolution><Secondary Neoplasm><Secondary Tumor><Single cell seq><Structure><Subcellular Process><System><Technical Expertise><Techniques><Technology><Time><Tissue Growth><Tissues><Training><Transcription Factor Proto-Oncogene><Transcription factor genes><Translational Research><Translational Science><Trees><Work><Xenograft Model><base editing><behavior study><behavioral study><benchmark><biologic><cancer metastasis><cardiogenesis><cell assay><cell dimension><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular lineage mapping><cellular lineage tracking><data interpretation><developmental><developmental disease><developmental disorder><driving><engineered progenitor cells><engineered stem cells><environmental risk><epigenetically><experience><experiment><experimental research><experimental study><experiments><gene editor><gene function><genetic determinant><genetically engineered mouse model><genetically engineered murine model><genome based testing><genome editing><genome editor><genome testing><genomic DNA testing><genomic based testing><genomic clinical testing><genomic editing><genomic profiling testing><genomic screening test><heart development><heart formation><heavy metal Pb><heavy metal lead><high throughput screening><histories><image-based method><imaging><imaging method><imaging modality><in vitro Model><in vivo><in vivo Model><insight><knockin><living system><mESC><mammary cancer model><mammary tumor model><mouse development><mouse model><multiomics><multiple omics><murine ES cells><murine ESC><murine embryonic progenitor><murine embryonic stem cell><murine model><neuromuscular><novel><ontogeny><panomics><peer><post-doc><post-doctoral><post-doctoral trainee><prime editing><progenitor><progenitor biology><progenitor cell biology><progenitor cell division><progenitor cell expansion><progenitor cell fate specification><progenitor cell model><progenitor cell pool><progenitor cell population><progenitor cell renewal><progenitor division><progenitor expansion><progenitor fate specification><progenitor model><progenitor pool><progenitor population><progenitor renewal><progenitor specification><programs><reconstruction><research associates><resolutions><single cell next generation sequencing><single cell sequencing><skills><stem and progenitor biology><stem and progenitor cell division><stem and progenitor cell expansion><stem and progenitor cell model><stem and progenitor cell population><stem and progenitor cell renewal><stem cell based model><stem cell biology><stem cell derived model><stem cell division><stem cell expansion><stem cell fate specification><stem cell model><stem cell pool><stem cell population><stem cell renewal><stem cell specification><stem cells><technical skills><therapeutic agent development><therapeutic development><three dimensional><tool><trait><transcription factor><translation research><translational investigation><tumor cell metastasis><xenograft transplant model><xenotransplant model>
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Fangtao Chi

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, MA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$90,000
FY 2026

Project Title

Enhancing intestinal regeneration with Cysteine mediated dietary intervention

Grant Number:

1K99DK146116-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract The small intestine, central to nutrient absorption like amino acids and lipids, houses highly responsive Lgr5+ intestinal stem cells (ISCs) in the crypt bottom. Over the past decade, our group and others have utilized the mouse intestine to investigate how dietary interven...

Research Terms

<Amino Acids><Anabolism><Autoregulation><Award><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Body Tissues><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cancers><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Growth and Maintenance><Cell Interaction><Cell Maintenance><Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Metabolic Process><Cholesterol><CoA><Coenzyme A><Complex><Coupled><Cues><Cysteine><Cystine><Diet><Dietary Intervention><Disease><Disorder><Education and Training><Environment><Epithelial Cells><Epithelium><Essential Amino Acids><Fasting><Food><GI Stem cell><Gene Expression><HG38><Half-Cystine><High Fat Diet><Homeostasis><IL-22><Immune><Immunes><In Vitro><Injections><Injury><Intestinal><Intestines><Intracellular Communication and Signaling><Intravenous><Investigators><KO mice><Ketone Bodies><Knock-out Mice><Knockout Mice><L-Cysteine><L-Cystine><LGR5><LGR5 gene><Lipids><LoxP-flanked allele><Lymphatic cell><Lymphocyte><Lymphocytic><Malignant Neoplasms><Malignant Tumor><Mediating><Metabolic><Metabolic Control><Metabolic Pathway><Metabolic dysfunction><Mice><Mice Mammals><Mitochondria><Modeling><Molecular><Murine><Mus><Natural regeneration><Null Mouse><Nutrient><Nutrition Interventions><Nutritional Interventions><Nutritional status><PPAR><PPAR alpha><PPAR delta><PPAR-α><PPAR-δ><PPARD protein><PPARalpha><PPARdelta><PPARα><PPARδ><Peroxisome Proliferator-Activated Receptor alpha><Peroxisome Proliferator-Activated Receptor delta><Peroxisome Proliferator-Activated Receptor α><Peroxisome Proliferator-Activated Receptor δ><Peroxisome Proliferator-Activated Receptors><Physiologic><Physiological><Physiological Homeostasis><Physiology><Play><Position><Positioning Attribute><Process><Production><Progenitor Cells><Pyruvate><Regeneration><Reporting><Research><Research Personnel><Research Resources><Researchers><Resources><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Small Intestines><Source><System><T-Cell Depletion><T-Cells><T-Lymphocyte><T-cell depletion therapy><T-lymphocyte depletion therapy><T8 Cells><T8 Lymphocytes><Tail><Tamoxifen><Testing><Tissues><Training><Training and Education><Transplantation><Upregulation><Veins><aminoacid><biological signal transduction><biosynthesis><bowel><career development><cell metabolism><cell type><cellular metabaolism><crypt cell><cytokine><diet intervention><dietary><diets><experiment><experimental research><experimental study><experiments><fasted><fasts><feeding><floxed><floxed allele><gain of function><gastrointestinal homeostasis><gastrointestinal stem cell><gut progenitor><gut stem cell><in vivo><injuries><injury to the intestines><interleukin-22><intestinal crypt><intestinal epithelium><intestinal homeostasis><intestinal injury><intestinal progenitor><intestinal stem cells><ketogenesis><loss of function><lymph cell><malignancy><mesenteric lymph node><mesentery lymph node><mitochondrial><mouse model><murine model><neoplasm/cancer><novel><nutrient absorption><overexpress><overexpression><paracrine><progenitor cell fate><progenitor cell function><progenitor cell proliferation><progenitor cell regeneration><progenitor cell self renewal><progenitor fate><progenitor function><progenitor proliferation><progenitor regeneration><progenitor self renewal><programs><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><repair><repaired><response><self-renew><self-renewal><small bowel><social role><stem and progenitor cell fate><stem and progenitor cell function><stem and progenitor cell proliferation><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor function><stem cell fate><stem cell function><stem cell proliferation><stem cell regeneration><stem cell self renewal><stem cells><sugar><thymus derived lymphocyte><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transplant><villin>
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Marcella Birtele

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Good lead · 56/100
Training-friendly
Very recent
Active award
Career award
$90,000
FY 2026

Project Title

Investigating Autism-Related Gut Dysfunction with Human Enteric Neurons and Intestinal Organoids

Grant Number:

1K99DK143293-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Gastrointestinal (GI) disorders are among the most common comorbidities in patients with Autism Spectrum Disorder (ASD). The Enteric Nervous System (ENS), composed of neurons (ENs) and glia, is crucial in regulating various aspects of gut physiology. Animal models show GI motility im...

Research Terms

<ASD><ATAC sequencing><ATAC-seq><ATACseq><Acceleration><Address><Affect><Animal Model><Animal Models and Related Studies><Animals><Antisense Agent><Antisense Oligonucleotides><Assay for Transposase-Accessible Chromatin using sequencing><Autism><Autistic Disorder><Brain Diseases><Brain Disorders><CRISPR correction><CRISPR-based correction><Calcium><Cas9-based correction><Cas9-mediated correction><Cell Body><Cell Line><Cell Nucleus><CellLine><Cells><Chromatin><Clinical><Co-culture><Cocultivation><Coculture><Coculture Techniques><Complex><DNA mutation><Data><Data Set><Development><Dysfunction><Early Infantile Autism><Encephalon Diseases><Enteral><Enteric><Enteric Nervous System><Expression Signature><Functional disorder><Functional impairment><GI Stem cell><Gastrointestinal Diseases><Gastrointestinal Motility><Gene Expression><Gene Expression Profile><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Glia><Glial Cells><Health Care><Heterogeneity><High Prevalence><High Throughput Assay><Human><Image><Impairment><In Situ Hybridization><In Vitro><In vivo two-photon calcium imaging><Individual><Induced pluripotent stem cell derived neurons><Infantile Autism><Intestinal><Intestines><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knock-out><Knockout><Knowledge><Kolliker's reticulum><Large Intestine><Link><Mentorship><Modeling><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Motility><Mutation><Nerve Cells><Nerve Unit><Nervous System Physiology><Neural Cell><Neural Crest><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic function><Neurological function><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neuronal Differentiation><Neurons><Non-neuronal cell><Nonneuronal cell><Nucleus><Organoids><Pathway interactions><Patients><Phase><Physiology><Physiopathology><Play><Postdoc><Postdoctoral Fellow><Procedures><Public Health><Publishing><RNA Expression><Reporting><Research><Research Associate><Risk-associated variant><Role><SYNGAP1><Strains Cell Lines><Structure><Synaptic Ras GTPase Activating Protein 1><System><Technology><Testing><Transcription><Transplantation><Work><antisense oligo><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><autism spectral disorder><autism spectrum disorder><autistic children><autistic individuals><autistic people><autistic spectrum disorder><bowel><candidate identification><cell type><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><co-morbid><co-morbidity><comorbidity><cultured cell line><developmental><disease phenotype><endophenotype><epigenomics><experiment><experimental research><experimental study><experiments><gastrointestinal><gastrointestinal disorder><gastrointestinal function><gastrointestinal stem cell><gastrointestinal symptom><gene expression pattern><gene expression signature><genome mutation><gut progenitor><gut stem cell><hiPSC><high throughput screening><human derived model><human derived platform><human derived system><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human like model><human like platform><human like system><human model><human specific alternative><human specific model><human specific platform><human specific system><human-based alternative><human-based biological models><human-based model><human-based nonanimal models><human-based platform><human-based research><human-based system><human-based tools><human-centered model><human-centered platform><human-centered research><human-centered system><human-focused research><human-relevant alternative><human-relevant model><human-relevant platform><human-relevant system><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><imaging><in situ Hybridization Genetics><in situ Hybridization Staining Method><in vivo Model><in vivo calcium imaging><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><inducible pluripotent cell><inducible pluripotent stem cell><insight><intestinal epithelium><intestinal progenitor><intestinal stem cells><knock-down><knockdown><large bowel><model of animal><model of human><molecular profile><molecular signature><mutant><nerve cement><nervous system development><nervous system function><neural><neuron development><neuronal><neuronal development><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><organoid transplantation><pathophysiology><pathway><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient-derived pluripotent stem cells><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><post-doc><post-doctoral><post-doctoral trainee><progenitor cell model><progenitor cell niche><progenitor model><progenitor niche><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><research associates><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scATAC sequencing><scATAC-seq><scRNA sequencing><scRNA-seq><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell sequencing assay for transposase accessible chromatin><single cell transcriptomic profiling><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell RNA sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><social role><stem and progenitor cell model><stem and progenitor cell niche><stem cell based model><stem cell derived model><stem cell model><stem cell niche><synapse function><synaptic function><transcriptional profile><transcriptional signature><transplant>
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Qing Nie

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$493,010
FY 2026

Project Title

Tissue Size and Precision Control in Growing Hair Follicles

Grant Number:

5R01AR079150-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Biological tissues appear to “know” their intended final sizes and achieve them precisely and robustly. While, in principle, a simple negative signaling feedback should be sufficient to explain how a given stem cell lineage regulates its cellular outputs, in reality it cannot work b...

Research Terms

<Affect><Animals><Biological><Biology><Body Tissues><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Interaction><Cell Lineage><Cell Signaling><Cell Size><Cell-to-Cell Interaction><Cells><Communication><Complex><Computational toolkit><Computer Models><Computerized Models><Corti Cell><DNA Synthesis Factor><Data><Dermal><Distant><Endothelial Cell Growth Factor><Epithelium><Equilibrium><Experimental Models><FGF><Feedback><Fibroblast Growth Factor><Fibroblast Growth Factor Gene Family><Fibroblast Growth Regulatory Factor><Generalized Growth><Genes><Genetic><Growth><Hair><Hair Cells><Hair Follicle><Hair follicle structure><Heterogeneity><In Vitro><Injury><Intracellular Communication and Signaling><Knowledge><Length><Lineage Tracing><Link><Math><Math Models><Mathematics><Mesenchymal><Methods><Mice><Mice Mammals><Microscopic><Modeling><Modernization><Molecular><Murine><Mus><Mutant Strains Mice><Normal Tissue><Normal tissue morphology><Organ><Output><Production><Progenitor Cells><Proliferating><Regulation><Reproducibility><Research><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Single cell seq><Site><Stem Cell Research><Study models><Testing><Tissue Growth><Tissues><Transplantation><Work><balance><balance function><base><bases><biologic><biological signal transduction><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular lineage mapping><cellular lineage tracking><computational modeling><computational models><computational toolbox><computational tools><computational toolset><computer based models><computer based prediction><computerized modeling><computerized tools><ear hair cell><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><experiment><experimental research><experimental study><experiments><gene regulatory network><in vitro Model><in vivo><injuries><innovate><innovation><innovative><mathematic model><mathematical model><mathematical modeling><mouse genetics><mouse mutant><mutant><network models><novel><ontogeny><overexpress><overexpression><papilla><predictive modeling><progenitor><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell next generation sequencing><single cell sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem><stem cell study><stem cells><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><tongue papilla><tool><transplant>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Maksim V Plikus

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$493,010
FY 2026

Project Title

Tissue Size and Precision Control in Growing Hair Follicles

Grant Number:

5R01AR079150-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Biological tissues appear to “know” their intended final sizes and achieve them precisely and robustly. While, in principle, a simple negative signaling feedback should be sufficient to explain how a given stem cell lineage regulates its cellular outputs, in reality it cannot work b...

Research Terms

<Affect><Animals><Biological><Biology><Body Tissues><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Interaction><Cell Lineage><Cell Signaling><Cell Size><Cell-to-Cell Interaction><Cells><Communication><Complex><Computational toolkit><Computer Models><Computerized Models><Corti Cell><DNA Synthesis Factor><Data><Dermal><Distant><Endothelial Cell Growth Factor><Epithelium><Equilibrium><Experimental Models><FGF><Feedback><Fibroblast Growth Factor><Fibroblast Growth Factor Gene Family><Fibroblast Growth Regulatory Factor><Generalized Growth><Genes><Genetic><Growth><Hair><Hair Cells><Hair Follicle><Hair follicle structure><Heterogeneity><In Vitro><Injury><Intracellular Communication and Signaling><Knowledge><Length><Lineage Tracing><Link><Math><Math Models><Mathematics><Mesenchymal><Methods><Mice><Mice Mammals><Microscopic><Modeling><Modernization><Molecular><Murine><Mus><Mutant Strains Mice><Normal Tissue><Normal tissue morphology><Organ><Output><Production><Progenitor Cells><Proliferating><Regulation><Reproducibility><Research><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Single cell seq><Site><Stem Cell Research><Study models><Testing><Tissue Growth><Tissues><Transplantation><Work><balance><balance function><base><bases><biologic><biological signal transduction><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular lineage mapping><cellular lineage tracking><computational modeling><computational models><computational toolbox><computational tools><computational toolset><computer based models><computer based prediction><computerized modeling><computerized tools><ear hair cell><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><experiment><experimental research><experimental study><experiments><gene regulatory network><in vitro Model><in vivo><injuries><innovate><innovation><innovative><mathematic model><mathematical model><mathematical modeling><mouse genetics><mouse mutant><mutant><network models><novel><ontogeny><overexpress><overexpression><papilla><predictive modeling><progenitor><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell next generation sequencing><single cell sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem><stem cell study><stem cells><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><tongue papilla><tool><transplant>
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Sunil K Chauhan

SCHEPENS EYE RESEARCH INSTITUTE, BOSTON, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$492,500
FY 2026

Project Title

Alloimmune-compatible stem cells for ocular diseases

Grant Number:

5R01EY036033-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY: Induced pluripotent stem cells (iPSCs) possess remarkable ability to transform into various cell types found in the eye, making them an exceptional cellular resource for regenerating ocular tissues. However, while the use of autologous iPSCs ensures immune compatibility, it still has no cli...

Research Terms

<ABC Transporter, MHC, 2><ABC17><ABCB2><ABCB3><APT2><ATP-Binding Cassette, Sub-Family B, Member 3><Address><Affect><Affinity><Allogenic><Antigen Peptide Transporter 2><Assay><Autologous><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Binding><Bioassay><Biochemical><Biological Assay><Body Tissues><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Line><Cell Protection><Cell Therapy><Cell Transplantation><Cell-Mediated Cytolysis><Cell-Mediated Lympholysis><CellLine><Cells><Cellular Cytotoxicity><Cessation of life><Class I Antigens><Class I Major Histocompatibility Antigens><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><Complex Class 1><Consumption><Cornea><Cytolysis><Cytoprotection><Cytotoxic cell><D6S114E><Data><Death><Development><ERp57><Endoderm><Endoderm Cell><Endodermal Cell><Engineering><Ensure><Enzyme Gene><Enzymes><Eye><Eye diseases><Eyeball><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Gene Deletion><Gene Inactivation><Gene Silencing><Generations><Genes><HL-A Antigens><HLA Antigens><Histocompatibility Antigens Class I><Human><Human Leukocyte Antigens><Immune><Immune response><Immune system><Immunes><Immunity><Immunocompetent><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><In Vitro><K lymphocyte><Knock-out><Knockout><Leukocyte Antigens><Lymphocyte Cytotoxicity><Lymphocytotoxicity><Lysis><Lytotoxicity><MHC Class I Molecule><MHC Class I Protein><MHC class I antigen><Major Histocompatibility Complex Class 1><Mediating><Mice><Mice Mammals><Modern Man><Molecular Interaction><Morbidity><Murine><Mus><NK Cells><NK T cell><NKT cell><Natural Killer Cells><Natural Killer T cell><Natural regeneration><PSF1><PSF2><Patients><Peptide Supply Factor 2><Peptide Transporter PSF2><Peptides><Pilot Projects><Process><Production><Progenitor Cells><RING11><RING4><Regeneration><Regenerative Medicine><Research Resources><Resources><Risk><Source><Standardization><Stem Cell like><Strains Cell Lines><Surface><System><T-Cell Activation><T8 Cells><T8 Lymphocytes><TAP-A protein><TAP1><TAP1 gene><TAP2><TAP2 gene><Techniques><Testing><Time><Tissues><Transgenes><Transplantation><Transporter, ATP-Binding Cassette, Major Histocompatibility Complex, 2><Validation><activate T cells><alloimmunity><allotransplant><allotransplantation><cell bank><cell based intervention><cell mediated cytotoxicity><cell mediated intervention><cell mediated therapies><cell transformation><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><cellular transplant><clinical applicability><clinical application><corneal><cost><cultured cell line><cytoprotective><cytotoxic><cytotoxic CD8 T cells><cytotoxic CD8 T lymphocyte><cytotoxicity><developmental><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><eye disorder><flow cytophotometry><gene deletion mutation><gene editing platform><gene editing system><gene editing technology><gene editing tools><gene-editing toolkit><hiPSC><host response><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><humanized mice><humanized mouse><iPS><iPSC><iPSCs><immune competent><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immunogenic><immunogenicity><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><isoimmunity><knockout gene><limbal><member><mouse model><murine model><natural killer T lymphocyte><novel><ocular disease><ocular disorder><ophthalmopathy><overexpress><overexpression><pilot study><pluripotency><pluripotent state><preservation><progenitor capacity><progenitor cell based therapy><progenitor cell like><progenitor cell therapy><progenitor cell treatment><progenitor therapy><progenitor treatment><progenitor-like><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regenerative><response><stem and progenitor cell therapy><stem cell based therapy><stem cell characteristics><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><stem-like><stemness><success><tapasin><technological innovation><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><tool><transcriptional silencing><transformed cells><transgene><transplant><validations>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

PAMELA LYNN WENZEL

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

Good lead · 52/100
Likely hiring
Solid budget
Active award
$490,437
FY 2026

Project Title

Biomechanical Determinants of Hematopoietic Stem Cell Potential

Grant Number:

5R01DK111599-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2018

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY The availability of donor-matched sources of hematopoietic stem cells (HSCs) continues to limit access to and outcomes following allogeneic HSC transplant. Unmet need for improved HSC sources has motivated global improvements in donor recruitment and matching, as well as enterprising...

Research Terms

<21+ years old><Active Oxygen><Address><Adult><Adult Human><Allogenic><Ampullary Crest><Architecture><Arterial Lines><Arteries><Assay><Bioassay><Bioenergetics><Biological Assay><Biological Mimetics><Biomechanics><Biomimetics><Biophysics><Blood Diseases><Blood Precursor Cell><Blood flow><Bone Marrow><Bone Marrow Reticuloendothelial System><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Ciclosporin><Co-culture><Cocultivation><Coculture><Coculture Techniques><Cord Blood><Crista ampullaris><CsA><Cues><Cyclosporin A><Cyclosporine><Cyclosporine A><Data><Data Set><Development><Embryo><Embryonic><Embryonic Heart><Endothelial Cells><Endothelium><Energy Expenditure><Energy Metabolism><Engineering><Engineering / Architecture><Engraftment><Exhibits><Frequencies><Funding><Generations><Genetic><Goals><HSC Specification><HSC emergence><HSC expansion><HSC formation><HSC production><HSC transplantation><Heart><Heart Muscle Cells><Heart myocyte><Hematologic Cancer><Hematologic Diseases><Hematologic Malignancies><Hematologic Neoplasms><Hematological Disease><Hematological Disorder><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoiesis><Hematopoietic><Hematopoietic Cancer><Hematopoietic Cell Production><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Specification><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Homing><In Vitro><Intermediary Metabolism><Interruption><Intra-Arterial Lines><Intracellular Communication and Signaling><Knowledge><Malignant Hematologic Neoplasm><Measures><Mediating><Membrane><Membrane Potentials><Metabolic><Metabolic Processes><Metabolism><Methods><Mitochondria><Modeling><Modification><Molecular><Morphology><Organelles><Outcome><Output><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxygen Consumption><Oxygen Radicals><Patients><Phase><Phenotype><Preparation><Pro-Oxidants><Process><Progenitor Cells><Proteins><Reactive Oxygen Species><Regulation><Regulatory Element><Reporting><Research><Resolution><Resting Potentials><Role><Sandimmun><SangCya><Signal Transduction><Signal Transduction Systems><Signaling><Site><Source><Specific qualifier value><Specified><Structure><Superoxide Anion><Superoxide Radical><Superoxides><Testing><Therapeutic><Therapeutic Uses><Transmembrane Potentials><Transplant-Related Disorder><Umbilical Cord Blood><Work><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><biological signal transduction><biomechanical><biophysical foundation><biophysical principles><biophysical sciences><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood progenitor cell expansion><blood progenitor expansion><blood stem cell><blood stem cell emergence><blood stem cell expansion><blood stem cell formation><blood stem cell transplantation><blood treatment><blood-forming stem cell><cardiomyocyte><crista ampulla><cristae><cyclosporin A-SPTP><cyclosporin A-sensitive pereability transition pore><defined contribution><design><designing><developmental><directed differentiation><disease model><disorder model><druggable target><embryo heart><emergence of hematopoietic stem cells><energy efficiency><fetal cord blood><global gene expression><global transcription profile><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic differentiation><hematopoietic gene><hematopoietic progenitor><hematopoietic progenitor cell expansion><hematopoietic progenitor cell fate><hematopoietic progenitor cell formation><hematopoietic progenitor cell transplantation><hematopoietic progenitor expansion><hematopoietic progenitor formation><hematopoietic stem and progenitor cell fate><hematopoietic stem cell emergence><hematopoietic stem cell expansion><hematopoietic stem cell fate><hematopoietic stem cell formation><hematopoietic stem cell production><hematopoietic stem progenitor cell><hemogenic endothelium><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><improved><in utero><inhibitor><insight><membrane structure><mitochondrial><mitochondrial megachannel><mitochondrial membrane><mitochondrial permeability transition pore><mutant><mutant mouse model><neoral><novel><peripheral blood><pharmacologic><preparations><progenitor><progenitor cell maintenance><progenitor cell pool><progenitor cell population><progenitor maintenance><progenitor pool><progenitor population><reconstitute><reconstitution><recruit><resolutions><sandimmune><scRNA sequencing><scRNA-seq><self-renew><self-renewal><shear stress><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><solute><stem and progenitor cell population><stem cell maintenance><stem cell pool><stem cell population><stem cells><transcriptome><transplant disease>
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Deepta Bhattacharya

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 52/100
Likely hiring
Solid budget
Active award
$477,398
FY 2026

Project Title

Engineering pluripotent stem cells to evade and promote immunity

Grant Number:

5R01EB035491-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY / ABSTRACT Pluripotent stem cells hold great promise for regenerative medicine. Beyond their ability to restore normal tissues, their potential can be expanded even further through engineering approaches to create new lineages with therapeutic properties that are not normally made in...

Research Terms

<AIDS Virus><Ab response><Ab-mediated immunity><Ab-mediated protection><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Allogenic><Anti-viral Agents><Antibodies><Antibody Formation><Antibody Production><Antibody immunity><Antibody protection><Antibody-mediated protection><Autologous><B blood cells><B cell><B cell differentiation><B cells><B lymphocyte differentiation><B-Cells><B-Lymphocytes><B-cell><Bioinformatics><Blood Plasma Cell><Blood Precursor Cell><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><CD19><CD19 gene><CD34><CD34 gene><Cell Body><Cell Communication and Signaling><Cell Line><Cell Lineage><Cell Signaling><Cell Therapy><CellLine><Cells><Chimera><Chimera organism><Clinical Treatment Moab><Communicable Diseases><Complex><Detection><Engineering><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Gene Transcription><Generations><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><Goals><HIV><HIV Antibodies><HIV-Associated Antibodies><HPCA1><HTLV-III Antibodies><HTLV-III-LAV Antibodies><Hematopoietic><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterograft><Heterologous Transplantation><Human><Human Engineering><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Antibodies><Immune><Immune Evasion><Immune system><Immunes><Immunity><Immunocompetent><In Vitro><Individual><Infection><Infectious Diseases><Infectious Disorder><Influenza Virus><Intervention><Intracellular Communication and Signaling><Knock-in><LAV Antibodies><LAV-HTLV-III><Lead><Long-term infection><Lymphadenopathy-Associated Antibodies><Lymphadenopathy-Associated Virus><Malaria><Methods><Mice><Mice Mammals><Modern Man><Modification><Monoclonal Antibodies><Murine><Mus><Nature><Normal Tissue><Normal tissue morphology><Output><Paludism><Pathway interactions><Pb element><Plasma Cells><Plasmacytes><Plasmodium><Plasmodium Infections><Pluripotent Stem Cells><Process><Property><RNA Expression><Recombinant DNA Technology><Regenerative Medicine><Reproducibility><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell Development><Strains Cell Lines><T cells for CAR><Technology><Therapeutic><Transcription><Transplantation><Vaccine Design><Vaccines><Virus-HIV><Xenograft><Xenograft Model><Xenograft procedure><Xenotransplantation><anti-viral compound><anti-viral drugs><anti-viral medication><anti-viral therapeutic><anti-virals><antibody biosynthesis><antibody-mediated immunity><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cell based intervention><cell engineering><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular engineering><cellular therapeutic><cellular therapy><chimeras><chimeric antigen T cell receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><chronic infection><cost><cultured cell line><differentiation of pluripotent stem cells><directed differentiation><engineered progenitor cells><engineered stem cells><epigenetically><flu serotype><flu strain><flu subtype><flu viral strain><flu virus strain><genetically engineered><genome editing><genomic editing><heavy metal Pb><heavy metal lead><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><human derived pluripotent stem cell><human embryogenesis><human embryonic development><human pluripotent stem cell><immune competent><immune evasive><immunoglobulin biosynthesis><in vivo><influenza serotype><influenza strain><influenza subtype><influenza viral strain><influenza virus strain><influenzavirus><insight><knockin><lymphocyte precursor><lymphocyte progenitor><lymphocyte stem cell><lymphoid precursor><lymphoid progenitors><lymphoid stem cell><mAbs><monoclonal Abs><neutralizing antibody><novel><pathogen><pathway><persistent infection><plasma cell development><plasmocyte><pluripotent progenitor><pluripotent stem cell differentiation><progenitor cell based therapy><progenitor cell development><progenitor cell therapy><progenitor cell treatment><progenitor development><progenitor therapy><progenitor treatment><protective effect><screening><screenings><small molecule><stem and progenitor cell development><stem and progenitor cell therapy><stem cell based therapy><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><transcriptomics><transplant><vector><xeno-transplant><xeno-transplantation><xenograft transplant model><xenotransplant model>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Christopher Michael Sturgeon

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 52/100
Likely hiring
Solid budget
Active award
$477,398
FY 2026

Project Title

Engineering pluripotent stem cells to evade and promote immunity

Grant Number:

5R01EB035491-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY / ABSTRACT Pluripotent stem cells hold great promise for regenerative medicine. Beyond their ability to restore normal tissues, their potential can be expanded even further through engineering approaches to create new lineages with therapeutic properties that are not normally made in...

Research Terms

<AIDS Virus><Ab response><Ab-mediated immunity><Ab-mediated protection><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Allogenic><Anti-viral Agents><Antibodies><Antibody Formation><Antibody Production><Antibody immunity><Antibody protection><Antibody-mediated protection><Autologous><B blood cells><B cell><B cell differentiation><B cells><B lymphocyte differentiation><B-Cells><B-Lymphocytes><B-cell><Bioinformatics><Blood Plasma Cell><Blood Precursor Cell><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><CD19><CD19 gene><CD34><CD34 gene><Cell Body><Cell Communication and Signaling><Cell Line><Cell Lineage><Cell Signaling><Cell Therapy><CellLine><Cells><Chimera><Chimera organism><Clinical Treatment Moab><Communicable Diseases><Complex><Detection><Engineering><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Gene Transcription><Generations><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><Goals><HIV><HIV Antibodies><HIV-Associated Antibodies><HPCA1><HTLV-III Antibodies><HTLV-III-LAV Antibodies><Hematopoietic><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterograft><Heterologous Transplantation><Human><Human Engineering><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Antibodies><Immune><Immune Evasion><Immune system><Immunes><Immunity><Immunocompetent><In Vitro><Individual><Infection><Infectious Diseases><Infectious Disorder><Influenza Virus><Intervention><Intracellular Communication and Signaling><Knock-in><LAV Antibodies><LAV-HTLV-III><Lead><Long-term infection><Lymphadenopathy-Associated Antibodies><Lymphadenopathy-Associated Virus><Malaria><Methods><Mice><Mice Mammals><Modern Man><Modification><Monoclonal Antibodies><Murine><Mus><Nature><Normal Tissue><Normal tissue morphology><Output><Paludism><Pathway interactions><Pb element><Plasma Cells><Plasmacytes><Plasmodium><Plasmodium Infections><Pluripotent Stem Cells><Process><Property><RNA Expression><Recombinant DNA Technology><Regenerative Medicine><Reproducibility><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell Development><Strains Cell Lines><T cells for CAR><Technology><Therapeutic><Transcription><Transplantation><Vaccine Design><Vaccines><Virus-HIV><Xenograft><Xenograft Model><Xenograft procedure><Xenotransplantation><anti-viral compound><anti-viral drugs><anti-viral medication><anti-viral therapeutic><anti-virals><antibody biosynthesis><antibody-mediated immunity><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cell based intervention><cell engineering><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular engineering><cellular therapeutic><cellular therapy><chimeras><chimeric antigen T cell receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><chronic infection><cost><cultured cell line><differentiation of pluripotent stem cells><directed differentiation><engineered progenitor cells><engineered stem cells><epigenetically><flu serotype><flu strain><flu subtype><flu viral strain><flu virus strain><genetically engineered><genome editing><genomic editing><heavy metal Pb><heavy metal lead><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><human derived pluripotent stem cell><human embryogenesis><human embryonic development><human pluripotent stem cell><immune competent><immune evasive><immunoglobulin biosynthesis><in vivo><influenza serotype><influenza strain><influenza subtype><influenza viral strain><influenza virus strain><influenzavirus><insight><knockin><lymphocyte precursor><lymphocyte progenitor><lymphocyte stem cell><lymphoid precursor><lymphoid progenitors><lymphoid stem cell><mAbs><monoclonal Abs><neutralizing antibody><novel><pathogen><pathway><persistent infection><plasma cell development><plasmocyte><pluripotent progenitor><pluripotent stem cell differentiation><progenitor cell based therapy><progenitor cell development><progenitor cell therapy><progenitor cell treatment><progenitor development><progenitor therapy><progenitor treatment><protective effect><screening><screenings><small molecule><stem and progenitor cell development><stem and progenitor cell therapy><stem cell based therapy><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><transcriptomics><transplant><vector><xeno-transplant><xeno-transplantation><xenograft transplant model><xenotransplant model>
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Tudorita Tumbar

CORNELL UNIVERSITY, ITHACA, NY

Good lead · 52/100
Likely hiring
Solid budget
Active award
$475,271
FY 2026

Project Title

Defining the heterogeneity of cell lineages in the inter-follicular epidermis

Grant Number:

5R01AR070157-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/12/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract Adult skin interfollicular epidermis (IFE) renewal is currently described by simple models of relatively homogenous basal stem/progenitor cells. However, long-term IFE renewal is likely orchestrated by the physiological demands of a complex tissue architecture comprising multiple levels of ...

Research Terms

<21+ years old><3-D><3-Dimensional><3D><Acute><Adult><Adult Human><Architecture><Area><Autoregulation><Basal Cell><Basal Layer><Basal Transcription Factor><Basal transcription factor genes><Behavior><Biological><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Lineage><Cell Multiplication><Cell Proliferation><Cell Signaling><Cell Survival><Cell Viability><Cell model><Cells><Cellular Proliferation><Cellular model><Complex><Data><Development><Engineering / Architecture><Epidermal Ridges><Epidermis><Exposure to ultraviolet radiation><Extinction><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genetic><Growth><Heterogeneity><Homeostasis><Human><Injury><Intracellular Communication and Signaling><Label><Laboratories><Light><Lineage Tracing><Link><Lymphatic><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Natural regeneration><Pattern><Phase><Photoradiation><Physiologic><Physiological><Physiological Homeostasis><Population><Progenitor Cells><Proliferating><Regeneration><Regenerative capacity><Research><Rete Malpighii><Rete Ridges><SOX6><SOX6 gene><SRY-Box 6><Science><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Skin development><Skin tissue regeneration><Spatial Distribution><Stratum Basale><Stratum Germinativum><Structure><Study models><Tail><Time><Tissue Growth><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><UV Radiation Exposure><UV exposure><UV induced><UV radiation-induced><UV response><Ultraviolet Radiation Related Exposure><Ultraviolet radiation exposure><Work><Wound Repair><adulthood><basal progenitor><basal stem cell><behavior change><biologic><biological signal transduction><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular lineage mapping><cellular lineage tracking><dermis regeneration><developmental><epidermal progenitor><epidermal progenitor cell><epidermal regeneration><epidermal stem cell><in vivo><injuries><injury and repair><molecular domain><mouse genetics><novel><ontogeny><progenitor cell pool><progenitor cell population><progenitor pool><progenitor population><regenerate><regenerate skin><regeneration ability><regeneration capacity><regeneration healing><regeneration potential><regenerative><regenerative cell><regenerative healing><regenerative potential><response><skin organogenesis><skin regeneration><stem><stem and progenitor cell population><stem cell pool><stem cell population><stem cells><three dimensional><tool><transcription factor><transcriptomics><ultraviolet exposure><ultraviolet induced><ultraviolet light exposure><ultraviolet light induced><ultraviolet radiation-induced><ultraviolet response><wound healing><wound recovery><wound resolution>
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Ya-Chieh Hsu

HARVARD UNIVERSITY, CAMBRIDGE, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$468,469
FY 2026

Project Title

Rapid functional genetics to study stem cell-niche interactions in the skin

Grant Number:

5R01AR080110-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/24/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Skin stem cells are heavily influenced by signals from their niches including different fibroblasts populations. While our ability to isolate and molecularly profile diverse cell types has improved drastically in the past decade, a major roadblock in identifying key genes driving ste...

Research Terms

<Ablation><Acceleration><Address><Adeno-Associated Viruses><Agonist><Alopecia><Arrector pili><Automobile Driving><Autoregulation><Baldness><Behavior><Biological><Body Tissues><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cholinergic Differentiation Factor><Chromatin><Communities><Corium><Cutaneous Disorder><Cutis><D-Factor><DNA Therapy><Data><Data Set><Dependoparvovirus><Dependovirus><Deposit><Deposition><Dermal><Dermatoses><Dermis><Development><Enhancers><Fibroblasts><Future><GDNF><GDNF gene><Gene Expression><Gene Transfer Clinical><Genes><Genetic><Genetic Intervention><Genetic Models><Goals><Hair><Hair Follicle><Hair follicle structure><Homeostasis><Immunofluorescence><Immunofluorescence Immunologic><Intracellular Communication and Signaling><Investigators><Involuntary Muscle><KO mice><Knock-out Mice><Knockout Mice><Knowledge><LIF><LIF gene><Maintenance><Measures><Mediating><Mediator><Methods><Mice><Mice Mammals><Molecular><Molecular Fingerprinting><Molecular Profiling><Murine><Mus><Muscle><Muscle Tissue><Natural regeneration><Nerve><Null Mouse><Organ><Physiologic><Physiological><Physiological Homeostasis><Pilor Erectus><Plasmids><Play><Population><Process><Progenitor Cells><Publications><RNA Seq><RNA sequencing><RNAseq><Regeneration><Regulatory Element><Research><Research Personnel><Researchers><Role><Scientific Publication><Serotyping><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Skin><Skin Diseases><Skin Diseases and Manifestations><Smooth Muscle><Specificity><Stem Cell Research><Testing><Therapeutic><Time><Tissues><Tropism><Viral><Work><Wound Repair><adeno associated virus group><biologic><biological signal transduction><cell behavior><cell type><cellular behavior><cutaneous disease><cutaneous stem cells><depository><dermal disease><dermal disorder><dermal progenitor><dermal stem cell><develop therapy><developmental><driving><gene function><gene manipulation><gene repair therapy><gene signatures><gene testing><gene therapy><gene-based testing><gene-based therapy><genetic manipulation><genetic signature><genetic testing><genetic therapy><genetically manipulate><genetically perturb><genomic therapy><glial cell-line derived neurotrophic factor><hair erector muscle><improved><in vivo><inhibitor><innervation><innovate><innovation><innovative><insight><intervention development><leukemia inhibitor factor><leukemia inhibitory factor><molecular profile><molecular signature><muscle system><muscular><muscular system><nerve supply><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new technology><new therapeutics><new therapy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel technologies><novel therapeutics><novel therapy><overexpress><overexpression><papilla><progenitor biology><progenitor cell biology><progenitor cell niche><progenitor niche><promoter><promotor><regenerate><repair><repaired><repository><scATAC sequencing><scATAC-seq><scRNA sequencing><scRNA-seq><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell next generation sequencing><single cell sequencing><single cell sequencing assay for transposase accessible chromatin><single cell transcriptomic profiling><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell RNA sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><skin disorder><skin progenitor><skin stem cell><social role><stem and progenitor biology><stem and progenitor cell niche><stem cell biology><stem cell niche><stem cell study><stem cells><success><therapy development><tongue papilla><tool><transcriptome sequencing><transcriptomic sequencing><treatment development><wound healing><wound recovery><wound resolution>
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Amy Ralston

MICHIGAN STATE UNIVERSITY, EAST LANSING, MI

Good lead · 52/100
Likely hiring
Solid budget
Active award
$466,378
FY 2026

Project Title

Molecular mechanisms regulating formation of diverse stem cell progenitors

Grant Number:

5R35GM131759-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2019

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT/SUMMARY My group seeks to discover how regulated gene expression enables cells to choose distinct fates during embryogenesis. We focus on aspects of embryogenesis that are unique to mammals, such as extraembryonic tissues, because these bear the greatest lessons for human health and for ste...

Research Terms

<Basal Transcription Factor><Basal transcription factor genes><Blastosphere><Body Tissues><Cell Body><Cell Reprogramming><Cells><Cells Placenta-Tissue><Chimera><Chimera organism><Development><Differentiation in cell culture><ES cell><Embryo><Embryo Development><Embryoblast><Embryogenesis><Embryology><Embryonic><Embryonic Development><Embryonic Tissue><Endoderm><Endoderm Cell><Endodermal Cell><Epiblast><Fertilization><Gene Expression><General Transcription Factor Gene><General Transcription Factors><Genomics><Gestation><Health><Human><Human Development><Image><In Vitro><In vitro cell differentiation><Induced pluripotency><Induced pluripotent state><Inner Cell Mass><Knock-out><Knockout><Knowledge><Mammalia><Mammals><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Mothers><Murine><Mus><Normal Placentoma><Pathologic><Placenta><Placenta Embryonic Tissue><Placentome><Pregnancy><Preimplantation Embryo><Progenitor Cells><Role><Somatic Cell><Study models><Time><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Umbilical Cord><Umbilical cord structure><Yolk Sac><blastocyst><blastula><cell type><cellular reprogramming><chimeras><developmental><differentiation in culture><differentiation in vitro><embryo cell><embryo derived stem cell><embryo tissue><embryonal stem cells><embryonic progenitor><embryonic stem cell><fertilizations><gene regulatory network><iPS><iPSC><iPSCs><imaging><in vitro cellular differentiation><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><pluripotency><pluripotent state><pre-implantation embryo><progenitor><progenitor biology><progenitor cell biology><progenitor cell model><progenitor model><progenitor-like cell><social role><stem><stem and progenitor biology><stem and progenitor cell model><stem cell based model><stem cell biology><stem cell derived model><stem cell model><stem cell of embryonic origin><stem cells><stem-like cell><tool><transcription factor><vitelline sac>
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Rita C. R. Perlingeiro

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 52/100
Likely hiring
Solid budget
Active award
$464,450
FY 2026

Project Title

Targeting Dystroglycanopathies using Pluripotent-derived Myogenic Progenitors

Grant Number:

5R01AR081882-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/10/2023

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Summary The biochemical hallmark of FKRP-associated dystroglycanopathies is the hypoglycosylation of α-dystroglycan (α-DG), which leads to disruption in the interaction of α-DG with extracellular matrix proteins, ultimately leading to muscle wasting. Recessive mutations in FKRP are associated with a...

Research Terms

<Address><Affect><Age><Allogenic><Assay><Autologous><Bioassay><Biochemical><Biological Assay><Cell Body><Cell Compartmentation><Cell Compartmentations><Cell Therapy><Cell Transplantation><Cells><Chemke syndrome><Chronic><Clinical Trials><Complication><DNA mutation><Development><Diaphragm><Engraftment><Environment><Extracellular Matrix Proteins><FKRP><Fibrosis><Future><Generations><Genes><Genetic Change><Genetic Diseases><Genetic defect><Genetic mutation><Greig cephalopolysyndactyly syndrome><Hootnick-Holmes syndrome><Human><Human Characteristics><Human Nature><Impairment><In Vitro><Injury><Investigation><LGMD2I><Limb-Girdle Muscular Dystrophies><MDC1C><Mesoderm><Metabolic Glycosylation><Methods><Mice><Mice Mammals><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Mononuclear><Murine><Mus><Muscle><Muscle Atrophy><Muscle Disease><Muscle Disorders><Muscle Fibers><Muscle Tissue><Muscle satellite cell><Muscular Atrophy><Muscular Diseases><Muscular Dystrophies><Mutation><Myodystrophica><Myodystrophy><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Myotubes><Natural regeneration><Pagon syndrome><Patients><Play><Pluripotent Stem Cells><Population><Progenitor Cell Transplantation><Regeneration><Regenerative Medicine><Respiratory Diaphragm><Rhabdomyocyte><Role><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Somatic Cell><Stem Cell Transplantation><Stem cell transplant><Technology><Therapeutic><Therapeutic Effect><Transplantation><Voluntary Muscle><Walker lissencephaly syndrome><Walker-Warburg syndrome><Warburg syndrome><ages><cell based intervention><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><cellular transplant><cephalopolysyndactyly syndrome><cerebro-ocular dysgenesis><cerebro-ocular dysgenesis-muscular dystrophy syndrome><cerebro-ocular dysplasia-muscular dystrophy><congenital encephalo-ophthalmic dysplasia><congenital muscular dystrophy><design><designing><developmental><disease model><disorder model><dystroglycanopathy><early onset><familial polysyndactyly-craniofacial anomalies syndrome><frontodigital syndrome><fukutin related protein><gene corrected><gene correction><genetic condition><genetic disorder><genome mutation><genomic correction><global gene expression><global transcription profile><glycosylation><human derived pluripotent stem cell><human pluripotent stem cell><hydrocephalus, agyria, retinal dysplasia with or without encephalocele syndrome><hypoimmunity><iPS><iPSC><iPSCs><immune deficiency><immunodeficiency><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><injuries><limb-girdle muscular weakness and atrophy><limb-girdle syndrome><molecular profile><molecular signature><mouse model><murine model><muscle breakdown><muscle degradation><muscle deterioration><muscle dystrophy><muscle fiber repair><muscle loss><muscle progenitor><muscle progenitor cell><muscle regeneration><muscle repair><muscle stem cell><muscle tissue repair><muscle wasting><muscular><muscular disorder><muscular repair><mutant><myopathic limb-girdle syndrome><pluripotent progenitor><polysyndactyly-craniofacial anomalies syndrome><polysyndactyly-craniofacial dysmorphism syndrome><polysyndactyly-dyscrania syndrome><polysyndactyly-peculiar skull syndrome><post-transplant><post-transplantation><posttransplant><posttransplantation><progenitor><progenitor cell based therapy><progenitor cell therapy><progenitor cell treatment><progenitor therapy><progenitor transplantation><progenitor treatment><programs><regenerate><regeneration potential><regenerative potential><respiratory><response><satellite cell><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skeletal><skull peculiar shape-polysyndactyly syndrome><social role><stem and progenitor cell therapy><stem and progenitor cell transplantations><stem cell based therapy><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><tissue degeneration><transcriptome><transplant><α-DG><α-Dystroglycan><αDG>
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Nikita Ruparel

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 52/100
Likely hiring
Solid budget
Active award
$463,838
FY 2026

Project Title

Evaluation of the Role of Macrophage Migratory Inhibitory Factor (MIF) in mediating Stem Cell Analgesia in a Model of Orofacial Pain

Grant Number:

5R01DE031352-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract/Project Summary The effectiveness and mechanisms of stem cell-induced analgesia in treating dental pain is unknown. We demonstrate that i.v. injections of human Stem Cells of Apical Papilla (hSCAP) reverse apical periodontitis (infection of a tooth; AP)-induced mechanical allodynia. Moreov...

Research Terms

<AMD-3100><AMD3100><APAP><Absence of pain sensation><Absence of sensibility to pain><Acetamidophenol><Acetaminophen><Acetominophen><Afferent Neurons><Animals><Antibodies><Apical><Apical Periodontitis><Attenuated><B. pertussis toxin><Behavior><Behavioral Assay><Body Tissues><Bordetella pertussis toxin><C-X-C Chemokine Receptor Type 4><CD184 Antigen><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CXC-R4><CXCR-4><CXCR4><CXCR4 Receptors><CXCR4 gene><Capsaicin><Cas nuclease technology><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Chemokine (C-X-C Motif) Receptor 4><Chemokine, CXC Motif, Receptor 4><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Co-culture><Cocultivation><Coculture><Coculture Techniques><D2S201E><Data><Degenerative Arthritis><Degenerative polyarthritis><Differences between sexes><Differs between sexes><Disease Progression><Effectiveness><Electrophysiology><Electrophysiology (science)><Endodontics><Evaluation><FB22><Feels no pain><Female><Fostering><Fusin><Goals><HM89><HSY3RR><Histamine-Sensitizing Factor><Home><Homing><Human><Hydroxyacetanilide><IAP Pertussis Toxin><Image><In Vitro><Infection><Injections><Intracellular Communication and Signaling><Islet-Activating Protein><Knock-out><Knockout><Knowledge><LAP3><LCR1><LESTR><LESTR Receptor><LPS-Associated Protein 3><Leukocyte-Derived Seven-Transmembrane Domain Receptor><Ligands><Lipopolysaccharide-Associated Protein 3><Long-term pain><Lymphocytosis-Promoting Factor><Macrophage><Mechanics><Mediating><Medical><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mice><Mice Mammals><Migraine><Migraine Headache><Modeling><Modern Man><Murine><Mus><Mφ><NPY3R><NPYR><NPYRL><NPYY3R><NSAIDs><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuropeptide Y Receptor Y3><Neurophysiology / Electrophysiology><No sensitivity to pain><Nociception><Non-Steroidal Anti-Inflammatory Agents><Odontalgia><Opiates><Opioid><Orofacial Pain><Osteoarthritis><Osteoarthrosis><Pain><Painful><Paracetamol><Pathway interactions><Patients><Periapical Granuloma><Periapical Periodontitis><Peripheral><Persistent pain><Pertussigen><Pertussis Toxin><Plerixafor><Progenitor Cells><Proteins><Receptor Protein><Regulation><Research><Rodent Model><Role><Route><SDF-1 Receptor><SDF1/PBSF Receptor CXCR4><Sensory Neurons><Sex Differences><Sexual differences><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Site><Spleen Seven-Transmembrane-Segment Receptor><Strains Cell Lines><Stromal Cell-Derived Factor 1 Receptor><System><Testing><Therapeutic><Tissues><Tooth><Tooth structure><Toothache><Trigeminal System><Upregulation><analgesia><antagonism><antagonist><antinociception><antinociceptive><attenuate><attenuates><attenuation><biological signal transduction><compare to control><comparison control><conditioned place preference><constant pain><cultured cell line><degenerative joint disease><dental pain><dentalgia><electrophysiological><experience><homes><human progenitor><human stem cells><hypertrophic arthritis><imaging><in vitro activity><in vivo><knock-down><knockdown><lasting pain><male><mechanic><mechanical><mechanical allodynia><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><microbial><mouse model><murine model><neuronal><neuropathic pain><nociceptive><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><non-steroidal anti-inflammatory drugs><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><on-going pain><ongoing pain><oral facial pain><orofacial><pain behavior><painful neuropathy><papilla><pathway><peripheral pain><place conditioning><programs><public health relevance><receptor><secondary analysis><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><shRNA><short hairpin RNA><side effect><small hairpin RNA><small molecule><social role><stem cells><teeth><tongue papilla><tooth pain><trigeminal><voltage><♀><♂>
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Meelad Dawlaty

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Good lead · 52/100
Likely hiring
Solid budget
Active award
$462,000
FY 2026

Project Title

Epigenetic regulation of embryonic stem cell biology by Tet enzymes

Grant Number:

5R35GM156415-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT The central goal of my research program is to establish the epigenetic mechanisms of gene regulation that govern the biology of embryonic stem cells (ESCs). We are interested in defining how ESC gene expression programs and biology are regulated by DNA methylation and the Tet family of DNA ...

Research Terms

<Biological><Biology><Causality><DNA><DNA Damage Repair><DNA Methylation><DNA Repair><Deoxyribonucleic Acid><Development><Disease><Disorder><ES cell><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Family><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Genes><Genome><Goals><Health><Hydroxylation><Mediating><Modification><Molecular><Mutate><Property><Reader><Regenerative Medicine><Regulation><Research><Role><Tet><Tetanus Helper Peptide><Unscheduled DNA Synthesis><Work><base><bases><biologic><carboxylation><causation><cell type><demethylation><developmental><disease causation><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><epigenetic regulation><epigenetically><human disease><iPS><iPSC><iPSCs><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><interest><novel><oxidation><pluripotency><pluripotent state><progenitor biology><progenitor cell biology><progenitor cell gene><progenitor gene><programs><social role><stem and progenitor biology><stem cell biology><stem cell genes><stem cell of embryonic origin><therapeutic target>
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Laijun Lai

UNIVERSITY OF CONNECTICUT STORRS, STORRS-MANSFIELD, CT

Good lead · 52/100
Likely hiring
Solid budget
Active award
$446,103
FY 2026

Project Title

Modeling and treating T cell immunodeficiency in CHARGE syndrome by ESC- and iPSC-derived thymic epithelial cells

Grant Number:

5R01AI175087-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary CHARGE syndrome is a complex of multiple congenital malformations and occurs in about 1:10,000 births worldwide. T cell Immunodeficiency is common (up to 80%) in CHARGE syndrome and is primarily due to impairment in thymic development. CHARGE patients with a profound immunodeficiency...

Research Terms

<22q11 Chromosomal Microdeletion Syndrome><22q11 Deletion Syndrome><22q11.2 deletion syndrome><22q11.2DS><22q11DS><Address><Antigens><Architecture><Autoantigens><Autologous><Autologous Antigens><Autosomal dominant Opitz G/BBB syndrome><Birth><Birth Defects><Blood Precursor Cell><Brachydanio rerio><CHARGE syndrome><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Causality><Cayler cardiofacial syndrome><Cell Body><Cell Therapy><Cells><Chromosome 22q11.2 deletion syndrome><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><DNA Binding><DNA Binding Interaction><DNA Helicases><DNA Unwinding Proteins><DNA bound><DNA mutation><DNA unwinding enzyme><Danio rerio><Defect><Development><Di George syndrome><DiGeorge Syndrome><DiGeorge anomaly><DiGeorge sequence><Disease><Disorder><ES cell><Embryo><Embryonic><Endoderm><Engineering / Architecture><Etiology><Gene Alteration><Gene Deletion><Gene Mutation><Genes><Genetic Change><Genetic defect><Genetic mutation><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterozygote><Human><Immune Tolerance><Immune response><Immunodeficient Mouse><Immunologic Tolerance><Impairment><In Vitro><Knock-out><Knockout><Laboratories><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Mouse ES Cell><Mouse ESC><Mouse Embryonic Progenitor><Mouse Embryonic Stem Cells><Murine><Mus><Mutation><Nature><Organ><Organogenesis><Parturition><Pathogenesis><Patients><Protocol><Protocols documentation><Reporting><Role><Sedlackova syndrome><Self-Antigens><Shprintzen syndrome><Somatic Cell><Source><Stem Cell Development><Supporting Cell><Syndrome><System><T-Cell Development><T-Cell Immunodeficiency><T-Cell Ontogeny><T-Cells><T-Lymphocyte><T-Lymphocyte Development><Techniques><Testing><Thymic Tissue><Thymic epithelial cell><Thymus><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Transplantation><Undifferentiated><Zebra Danio><Zebra Fish><Zebrafish><adult progenitor><adult stem cell><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><causation><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><charges for treatment><congenital anomaly><conotruncal anomaly face syndrome><developmental><differentiation protocol><disease causation><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><familial third and fourth pharyngeal pouch syndrome><gene corrected><gene correction><gene defect><gene deletion mutation><genome mutation><genomic correction><global gene expression><global transcription profile><hESC><helicase><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><heterozygosity><hiPSC><host response><human ES cell><human ESC><human embryogenesis><human embryonic development><human embryonic stem cell><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><hypoimmunity><iPS><iPSC><iPSCs><immune deficiency><immune system response><immune system tolerance><immune unresponsiveness><immunodeficiency><immunogen><immunological paralysis><immunoresponse><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><knock-down><knockdown><loss of function><mESC><murine ES cells><murine ESC><murine embryonic progenitor><murine embryonic stem cell><mutant allele><novel><pharyngeal pouch syndrome><progenitor cell development><progenitor development><reconstitute><reconstitution><social role><somatic progenitor><somatic stem cell><stem and progenitor cell development><stem cell of embryonic origin><third and fourth pharyngeal pouch syndrome><thymic and parathyroid agenesis syndrome><thymic aplasia><thymic aplasia syndrome><thymus derived lymphocyte><thymus transplantation><transcriptome><transplant><treatment charges><treatment fees><velo-cardio-facial syndrome><velocardiofacial syndrome><velofacial hypoplasia>
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Ravindra Majeti

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$443,413
FY 2026

Project Title

Functional Interrogation of Human Acute Myeloid Leukemia Stem Cells

Grant Number:

5R01CA288731-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Studies over the last several decades have led to a model that human AML is organized as a cellular hierarchy initiated and maintained by self-renewing leukemia stem cells (LSCs). The lack of functional studies has limited the understanding of human AML LSCs and the utility of this s...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AML - Acute Myeloid Leukemia><APAF-3><APAF3><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Adult><Adult Human><Affect><Aged 65 and Over><Allogenic><Apaf-3 protein><Apoptosis><Apoptosis Pathway><Apoptosis-Related Cysteine Protease Caspase 9><Apoptosis-Related Cysteine Protease Gene Caspase 9><Apoptotic Protease Activating Factor 3><Apoptotic Protease Activating Factor 3 Gene><Apoptotic Protease MCH-6><Apoptotic Protease MCH-6 Gene><B23><Bar Codes><Blood><Blood Reticuloendothelial System><Bone Marrow><Bone Marrow Reticuloendothelial System><CASP-9><CASP9><CASP9 Protein><CASP9 gene><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancers><Cas nuclease technology><Caspase-9 Gene><Cell Body><Cells><Chromatin><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><DNA mutation><DNMT3a><Data><Development and Research><Disease><Disorder><Engineering><Engraftment><Frequencies><Gene Expression><Genes><Genetic Change><Genetic defect><Genetic mutation><Genome><Genome engineering><Genomics><HSC transplantation><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Heterogeneity><Heterograft><Heterologous Transplantation><High Dose Chemotherapy><Human><ICE-LAP6><ICE-LAP6 Gene><ICE-LAP6 protein><ICE-Like Apoptotic Protease 6><ICE-Like Apoptotic Protease 6 Gene><Individual><Leukemic progenitor and stem cell><Lineage Tracing><MCH6><Maintenance><Malignant Neoplasms><Malignant Tumor><Mch6 protein><Mediating><Methods><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Murine><Mus><Mutation><Myeloid Cells><NPM><NPM1><NPM1 gene><Non-Polyadenylated RNA><Patients><Population><Programmed Cell Death><Property><Proteins><R & D><R&D><RNA><RNA Gene Products><Recombinant adeno-associated virus><Recombinant adeno-associated virus (rAAV)><Relapse><Resolution><Ribonucleic Acid><Sampling><Stem Cell Research><Therapeutic><Translational Research><Translational Science><Transplantation><United States><Xenograft><Xenograft procedure><Xenotransplantation><above age 65><acute granulocytic leukemia><acute granulocytic leukemia cell><acute myeloblastic leukemia cell><acute myelocytic leukemia cell><acute myelogenous leukemia cell><acute myeloid leukemia><acute myeloid leukemia cell><acute nonlymphocytic leukemia cell><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><aggressive therapy><aggressive treatment><barcode><blood stem cell transplantation><caspase-9><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><genome mutation><hDNA methyltransferase 3a><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><human old age (65+)><iPS><iPSC><iPSCs><in vivo><in vivo engraftment><induced Cre><induced pluripotent cell><induced pluripotent stem cell><inducible Cre><inducible pluripotent cell><inducible pluripotent stem cell><leukemia><leukemia stem/initiating cells><leukemia treatment><leukemic progenitor><leukemic stem cell><leukemic therapy><malignancy><mitochondrial><mutation correction><neoplasm/cancer><novel><over 65 years><progenitor biology><progenitor cell biology><progenitor cell model><progenitor model><rAAV><recombinant AAV><repair><repaired><research and development><resolutions><response to therapy><response to treatment><scATAC sequencing><scATAC-seq><self-renew><self-renewal><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell sequencing assay for transposase accessible chromatin><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><standard of care><stem and progenitor biology><stem and progenitor cell model><stem cell based model><stem cell biology><stem cell depletion><stem cell derived model><stem cell exhaustion><stem cell fatigue><stem cell model><stem cell study><therapeutic response><therapy response><translation research><translational investigation><translational model><translational study><transplant><treatment response><treatment responsiveness><xeno-transplant><xeno-transplantation><≥65 years>
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Nu Zhang

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 52/100
Likely hiring
Solid budget
Active award
$441,601
FY 2026

Project Title

Lymphoid residency of Tcf-1+ CD8+ T cells during tumor vaccine responses

Grant Number:

5R01AI177345-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Tumor immunotherapies represent the most exciting advance for cancer patients in recent decades. However, only a minor proportion of treated patients experience long-lasting benefits from current tumor immunotherapies. A subset of tumor-specific T lymphocytes carrying features of me...

Research Terms

<Acute><Address><Adjuvant><Advanced Cancer><Advanced Malignant Neoplasm><Antigens><Antineoplastic Vaccine><Biology><Body Tissues><Bone-Derived Transforming Growth Factor><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cancer Patient><Cancer Vaccines><Cancers><Cell Body><Cells><Cellular biology><Chronic><Defect><Development><Exhibits><Future><Gametes><Gene Transcription><Genetic Induction><Genetic Transcription><Germ Cells><Germ-Line Cells><History><Immune><Immune response><Immunes><Immunity><Infiltration><Investigation><Knowledge><Lymph Node Tissue><Lymphoid><Malignant Neoplasms><Malignant Tumor><Memory><Milk Growth Factor><Modeling><Mucosa><Mucosal Tissue><Mucous Membrane><Names><Neoplasm Vaccines><Organ><Patients><Pattern><Platelet Transforming Growth Factor><Play><Population><Process><Progenitor Cells><Property><Public Health><RNA Expression><Recording of previous events><Reproductive Cells><Residencies><Series><Sex Cell><Site><Stem Cell like><Surface><System><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell differentiation><T cell directed therapies><T cell factor 1><T cell immune therapy><T cell immunotherapy><T cell response><T cell targeted therapeutics><T cell therapy><T cell transcription factor 1><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T memory cell><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T-cell therapeutics><T-cell transfer therapy><T8 Cells><T8 Lymphocytes><TCF-1 protein><TGF B><TGF-beta><TGF-beta Receptors><TGF-β><TGF-β Receptors><TGFbeta><TGFβ><Testing><Tissues><Transcription><Transforming Growth Factor beta><Transforming Growth Factor beta Receptors><Transforming Growth Factor β Receptors><Transforming Growth Factor-Beta Family Gene><Transforming Growth Factors><Transgenic Organisms><Travel><Tumor Growth Factors><Tumor Immunity><Tumor Vaccines><VAC-TX><Vaccine Therapy><Viral Diseases><Virus Diseases><acute infection><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><anti-tumor immune therapy><anti-tumor immunity><anti-tumor immunotherapy><anti-tumor vaccine><antitumor immunity><cancer immunity><cancer microenvironment><cancer vaccination><cell biology><check point blockade><checkpoint blockade><developmental><draining lymph node><experience><gene signatures><genetic signature><histories><host response><immune check point blockade><immune checkpoint blockade><immune system response><immunogen><immunoresponse><improved><improved outcome><in vivo><initial cell><insight><intervention design><malignancy><memory T lymphocyte><migration><mouse model><murine model><name><named><naming><neoplasm immunotherapy><neoplasm/cancer><novel><pathogen><prevent><preventing><progenitor><progenitor capacity><progenitor cell differentiation><progenitor cell like><progenitor cell pool><progenitor cell population><progenitor differentiation><progenitor pool><progenitor population><progenitor-like><programs><public health relevance><rational design><regional lymph node><resident memory T cell><response><sexual cell><stem><stem and progenitor cell population><stem and progenitor differentiation><stem cell characteristics><stem cell differentiation><stem cell pool><stem cell population><stem cells><stem-like><stemness><therapeutic T-cell platform><therapeutic vaccination><therapy design><thymus derived lymphocyte><tissue resident memory T cell><transforming growth factors Animal growth regulators><transgenic><translational opportunities><translational potential><treatment design><tumor><tumor immune therapy><tumor immunotherapy><tumor microenvironment><tumor vaccination><vaccine efficacy><vaccine for cancer><vaccine response><vaccine responsiveness><vaccine-induced response><viral infection><virus infection><virus-induced disease>
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Andreia M. Ionescu

NORTHEASTERN UNIVERSITY, BOSTON, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$439,747
FY 2026

Project Title

Growth plate cartilage stem cells for skeletal repair after injury

Grant Number:

5R01AR082426-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

11/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Summary Injuries to the growth plate (GP) remain a major cause of morbidity in children, often leading to angular limb deformities and even complete growth arrest. Slipped Capital Femoral Epiphysis (SCFE), a transverse Salter-Harris type 1 (SH1) fracture, where the spherical femoral head of the hip...

Research Terms

<0-11 years old><21+ years old><Ablation><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Anatomic Abnormality><Anatomical Abnormality><Antibodies><Arthritis><Assay><Autograft><Autologous Stem Cell Transplantation><Autologous Transplantation><Autotransplant><Bioassay><Biological Assay><Biomedical Engineering><Bone Formation><Bone-Derived Transforming Growth Factor><Capital><Cartilage><Cartilaginous Tissue><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Line><Cell Signaling><Cell Transplantation><CellLine><Cells><Child><Child Youth><Children (0-21)><Chondrocytes><Clonogenic Cell Assay><Colony-Forming Units Assay><Colony-forming units><Corynebacterium Diphtheriae Toxin><Coxa><Defect><Deformity><Development><Diphtheria Toxin><Disease><Disorder><Engraftment><Epiphyseal Plate><Epiphysial cartilage><Equilibrium><Extremities><Femur><Fracture><Fracture Healing><Generalized Growth><Growth><Growth Plate><Hip><Hip Joint><Hip region structure><Hyaline Cartilage><Hypercalcemic Hormone of Malignancy><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><In Vitro><Infiltration><Injury><Intracellular Communication and Signaling><Investigators><Isoforms><Leg Length Inequality><Length of Life><Lesion><Limb structure><Limbs><Literature><Longevity><Maps><Mesenchymal><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Metaphysis><Mice><Mice Mammals><Milk Growth Factor><Monitor><Morbidity><Murine><Mus><Natural regeneration><Neck><Needles><Non-Trunk><Operative Procedures><Operative Surgical Procedures><Osteogenesis><PTH Like Tumor Factor><PTH-Like Protein><PTH-Related Peptide><PTHrP><Pain><Painful><Parathyroid Hormone Like Tumor Factor><Parathyroid Hormone-Like Hormone><Parathyroid Hormone-Like Protein><Parathyroid Hormone-Related Peptide><Pattern><Physiologic pulse><Platelet Transforming Growth Factor><Population><Process><Progenitor Cells><Property><Protein Isoforms><Pulse><Recombinant Parathyroid Hormone-Related Protein><Regeneration><Research Personnel><Researchers><Ribs><Role><Signal Transduction><Signal Transduction Systems><Signaling><Site><Staining method><Stains><Stem Cell like><Strains Cell Lines><Surgical><Surgical Interventions><Surgical Models><Surgical Procedure><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Testing><Therapeutic><Time><Tissue Growth><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Transplantation><Tumor Hypercalcemic Factor><adulthood><arthritic><autologous graft><autotransplantation><balance><balance function><bio-engineered><bio-engineers><bioengineering><biological engineering><biological signal transduction><bone><bone cell><bone fracture><bone fracture healing><bone fracture repair><bone progenitor><bone stem cell><bone tissue formation><cartilage regeneration><cartilage repair><cell type><cellular differentiation><cellular transplant><cultured cell line><developmental><disability><femur head><fracture repair><healing><in vivo><injured><injuries><injury response><insight><juvenile><juvenile human><kids><matrigel><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><migration><multipotency><multipotent><neutralizing antibody><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><osteoblast progenitor><osteoblast stem cell><osteogenic progenitor><osteogenic stem cell><osteoprogenitor><osteoprogenitor cell><parathyroid hormone-related protein><prevent><preventing><progenitor capacity><progenitor cell expansion><progenitor cell like><progenitor cell migration><progenitor expansion><progenitor migration><progenitor-like><reconstitute><reconstitution><regenerate><repair><repaired><response><response to injury><rib bone structure><self-renew><self-renewal><skeletal><skeletal progenitor><skeletal progenitor cell><skeletal stem cell><social role><stem and progenitor cell expansion><stem cell characteristics><stem cell expansion><stem cell migration><stem cells><stem-like><stemness><surgery><tibia><timeline><tissue wound><transcriptomics><transplant><wound><wounding><wounds><youngster>
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Yang Chai

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$434,693
FY 2026

Project Title

MOLECULAR REGULATORY MECHANISM OF MESENCHYMAL STEM CELLS IN ADULT MOUSE INCISOR

Grant Number:

5R01DE025221-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2016

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Regulation of stem cell functions is crucial for tissue formation, growth, and homeostasis. In many tissues and organs, stem cells give rise to transit amplifying cells (TACs), an undifferentiated progenitor population. TACs function as transient but indispensable integrator...

Research Terms

<21+ years old><ARID1A><ARID1A gene><AT- rich interactive domain-containing protein 1A><AT-rich interactive domain 1A gene><AVIL gene><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Animals><Antioncogene Protein p53><Autoregulation><Body Tissues><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Interaction><Cell Physiology><Cell Process><Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Tumor Antigen P53><Cervical><Cranial Nerve V><Data><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><FGFBR><FGFR1><FGFR1 gene><FLG Gene><FLT2 Gene><FMS-Like Gene><FMS-Like Tyrosine Kinase 2 Gene><Feedback><Fibroblast Growth Factor Receptor 1 Gene><Fifth Cranial Nerve><GLI Family Gene><GLI Family Protein><GLI Protein><GLI gene><GLI1><GLI1 Gene><GLI1 Protein><Generalized Growth><Glioma Associated Oncogene Homolog 1 Protein><Glioma Associated Oncogene Homolog Protein><Glioma-Associated Oncogene Homolog><Glioma-associated oncogene><Growth><Homeostasis><Incisor><Intracellular Communication and Signaling><Life><Maintenance><Mediating><Mesenchymal><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Mutant Strains Mice><Nerve><Nervus Trigeminus><Oncoprotein p53><Organ><Organism><P53><Phenotype><Phosphoprotein P53><Phosphoprotein pp53><Physiological Homeostasis><Play><Population><Position><Positioning Attribute><Progenitor Cells><Protein TP53><Regenerating teeth><Regenerating tooth><Regulation><Role><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Stem Cell Research><Subcellular Process><TP53><TP53 gene><TRP53><Teeth regeneration><Testing><Tissue Growth><Tissues><Tooth><Tooth regeneration><Tooth structure><Trigeminal Nerve><Trigeminal nerve structure><Tumor Protein p53><Tumor Protein p53 Gene><Undifferentiated><adult progenitor><adult stem cell><adulthood><advillin><biological signal transduction><cellular differentiation><epigenetically><glioma associated oncogene 1><glioma associated oncogene family zinc finger 1><innervation><insight><living system><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><model of animal><mouse mutant><nerve supply><neuro-vascular><neurovascular><ontogeny><p53 Antigen><p53 Genes><p53 Tumor Suppressor><progenitor cell differentiation><progenitor cell function><progenitor cell model><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor differentiation><progenitor function><progenitor model><progenitor niche><progenitor pool><progenitor population><protein p53><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><repair><repaired><scRNA sequencing><scRNA-seq><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><somatic progenitor><somatic stem cell><stem and progenitor cell function><stem and progenitor cell model><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor differentiation><stem and progenitor function><stem cell based model><stem cell derived model><stem cell differentiation><stem cell function><stem cell model><stem cell niche><stem cell pool><stem cell population><stem cell study><stem cells><teeth><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration>
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Tin Tin Su

UNIVERSITY OF COLORADO, Boulder, CO

Good lead · 52/100
Likely hiring
Solid budget
Active award
$430,375
FY 2026

Project Title

Cellular plasticity and regeneration afterradiation damage in Drosophila

Grant Number:

5R35GM130374-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2019

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Cellular plasticity and regeneration after radiation damage in Drosophila Cellular plasticity and regeneration after radiation damage in Drosophila More than half of cancer patients receive ionizing radiation (IR), alone or as a component of their treatment (www.cancer.org). IR induces DNA damage t...

Research Terms

<Affect><Apoptotic><Assay><Bioassay><Biogenesis><Biological Assay><Cancer Model><Cancer Patient><Cancer Radiotherapy><Cancer Treatment><CancerModel><Cancers><Caspase><Caspase Gene><Cell Body><Cell Death><Cell Survival><Cell Viability><Cell-Death Protease><Cells><Chemicals><Columnar Epithelium><Cysteine Endopeptidases><Cysteine Protease><Cysteine Proteinases><DNA Damage Repair><DNA Repair><Dedications><Development><Drosophila><Drosophila genus><Drosophila melanogaster><Drugs><Epithelial Cells><Funding><Future><Generalized Growth><Genes><Genetic><Goals><Growth><Human><ICE-like protease><Induction of Apoptosis><Ionizing Electromagnetic Radiation><Ionizing radiation><Lead><Learning><Lineage Tracing><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Medication><Modeling><Modern Man><Molecular><Molecular Analysis><Natural regeneration><Organ><Organism><Origin of Life><Pb element><Pharmaceutical Preparations><Process><Property><Proteins><Proteome><Radiation Induced DNA Damage><Radiation Induced Genotoxicity><Radiation induced damage><Radiation therapy><Radiation-Ionizing Total><Radiotherapeutics><Radiotherapy><Refractory><Regeneration><Research><Ribosomes><Stem Cell like><Testing><Tissue Growth><Translating><Translations><Treatment Failure><Treatment outcome><Unscheduled DNA Synthesis><Vertebrate Animals><Vertebrates><Wing><Work><anti-cancer therapy><cancer cell><cancer radiation therapy><cancer survival><cancer therapy><cancer-directed therapy><cell killing><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell regeneration><cell type><cellular lineage mapping><cellular lineage tracking><cellular regeneration><cystein protease><cystein proteinase><cysteine endopeptidase><developmental><drug/agent><fruit fly><gene function><global gene expression><global transcription profile><heavy metal Pb><heavy metal lead><imaginal disc><improved><in vivo><innovate><innovation><innovative><ionizing output><living system><malignancy><necrocytosis><neoplasm/cancer><ontogeny><prevent><preventing><progenitor capacity><progenitor cell like><progenitor cell pool><progenitor cell population><progenitor pool><progenitor population><progenitor-like><programs><radiation damage><radiation damage to DNA><radiation treatment><radiation-induced DNA breaks><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><stem and progenitor cell population><stem cell characteristics><stem cell pool><stem cell population><stem-like><stemness><therapy failure><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><tool><transcriptome><translation><treatment with radiation><tumor><vertebrata>
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Xiaofeng Jia

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 52/100
Likely hiring
Solid budget
Active award
$429,947
FY 2026

Project Title

Stem Cell Surface Modification to Promote Nerve Regeneration

Grant Number:

5R01NS117102-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2021

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Peripheral nerve injury, especially critical-sized nerve gap injury, often results in poor recovery of function and impaired quality of life for the patient. Stem cell therapy holds significant promise; however, its clinical application has been largely hampered by limited stem cell ...

Research Terms

<Address><Adhesions><Autograft><Autologous><Autologous Transplantation><Autotransplant><Body Tissues><Cell Adhesion><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Survival><Cell Therapy><Cell Transplantation><Cell Viability><Cell surface><Cell-Cell Adhesion><Cell-Extracellular Matrix><Cells><Cellular Adhesion><Chronic><Clinical><Clinical Research><Clinical Study><Clinical Treatment><Data><Derivation><Derivation procedure><Development><Differentiation in cell culture><Distal><Dose><E-stim><ECM><Electric Stimulation><Electrophysiology><Electrophysiology (science)><Environment><Extracellular Matrix><Fat progenitor cell><Fat stem cell><Foundations><Future><Glycans><Glycoengineering><Growth Agents><Growth Factor><Growth Substances><Harvest><Human><Impairment><In Vitro><In vitro cell differentiation><In vivo analysis><Injury><Mercaptans><Mercapto Compounds><Metabolic><Methodology><Methods><Modern Man><Modification><Morbidity><Muscle Disease><Muscle Disorders><Muscular Diseases><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Natural regeneration><Nature><Nerve><Nerve Cells><Nerve Regeneration><Nerve Unit><Neural Cell><Neural Stem Cell><Neuro-regeneration><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Neuroregeneration><Operative Procedures><Operative Surgical Procedures><Oral><Otomy><Outcome><Pathway interactions><Patients><Peripheral Nerves><Peripheral nerve injury><Polysaccharides><Procedures><Progenitor Cell Transplantation><Progenitor Cells><Proliferating><Property><Proteins Growth Factors><Protocol><Protocols documentation><QOL><Quality of life><Recovery of Function><Regeneration><Regenerative Medicine><Regulation><Safety><Series><Signal Pathway><Source><Stem Cell Transplantation><Stem cell transplant><Sulfhydryl Compounds><Surface><Surface Properties><Surgical><Surgical Interventions><Surgical Procedure><Surgical incisions><Techniques><Technology><Testing><Thiols><Time><Tissues><Transplantation><Trauma><Work><adipocyte progenitors><adipocyte stem cell><adipocyte-derived stem cell><adipose derived stem cell><adipose progenitor><adipose stem cell><adipose tissue derived stem cell><adipose tissue stem cells><analog><autologous graft><autotransplantation><cell based intervention><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular differentiation><cellular therapeutic><cellular therapy><cellular transplant><clinical applicability><clinical application><clinical intervention><clinical therapy><cost><determine efficacy><developmental><differentiation in culture><differentiation in vitro><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electrophysiological><electrostimulation><enthusiastic atmosphere><enthusiastic environment><evaluate efficacy><examine efficacy><fat derived stem cell><functional outcomes><functional recovery><improved><improved outcome><in vitro Assay><in vitro cellular differentiation><in vivo><in vivo evaluation><in vivo testing><incision><injuries><innovate><innovation><innovative><migration><muscular disorder><nerve gap><nerve injury><nerve reconstruction><nerve repair><nerve stem cell><nervous system regeneration><neural injury><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural regeneration><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><neuroregenerative><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathway><peripheral nerve crush injuries><peripheral nerve regeneration><peripheral nerve repair><progenitor and neural stem cells><progenitor cell based therapy><progenitor cell therapy><progenitor cell treatment><progenitor therapy><progenitor transplantation><progenitor treatment><regenerate><regenerated nerve><repair><repair model><repaired><sciatic nerve><stem and progenitor cell therapy><stem and progenitor cell transplantations><stem cell based therapy><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><success><sugar><sulfhydryl group><supportive atmosphere><supportive environment><surgery><therapy optimization><transplant><treatment optimization><trial regimen><trial treatment>
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Raquel Espin Palazon

IOWA STATE UNIVERSITY, AMES, IA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$428,815
FY 2026

Project Title

Molecular dissection of Hematopoietic Stem Cell specification triggered by inflammatory mediators

Grant Number:

5R01DK131162-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Due to the unique property of hematopoietic stem cells (HSCs) to reconstitute the entire blood system of the organism, these stem cells are utilized clinically to treat blood disorders. The possibility of culturing and expanding HSCs in vitro would make hematopoietic stem cell trans...

Research Terms

<Actions of Nitric Oxide in the Heart><Address><Affect><Anemia><Binding><Bioinformatics><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Brachydanio rerio><CARD3><CARDIAK><CRISPR><CRISPR/Cas system><CUT&RUN><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Stress><Cellular Stress Response><Chromatin><Cleavage Targets and Release Using Nuclease><Cleavage Under Targets and Release Using Nuclease><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Complement><Complement Proteins><DNA Synthesis Factor><Danio rerio><Data><Development><Dissection><Endogenous Nitrate Vasodilator><Endothelial Cell Growth Factor><Endothelium-Derived Nitric Oxide><Epistasis><Epistatic Deviation><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><FGF><Family member><Fibroblast Growth Factor><Fibroblast Growth Factor Gene Family><Fibroblast Growth Regulatory Factor><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Generations><Genes><Genetic><Genetic Epistasis><Goals><HSC Specification><HSC emergence><HSC expansion><HSC production><HSC transplantation><Health><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic><Hematopoietic Cell Production><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Specification><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Hemoglobinopathies><Human><IFN><Image><Immune system><Immunoglobulin Enhancer-Binding Protein><In Vitro><Inflammasome><Inflammation><Inflammation Mediators><Inflammatory><Interaction Deviation><Interferons><Intracellular Communication and Signaling><Investigation><Investigators><Kinases><Knowledge><Laboratories><Light><Lineage Tracing><Mediating><Methods><Microscopy><Modeling><Modern Man><Molecular><Molecular Interaction><Mononitrogen Monoxide><NF-kB><NF-kappa B><NF-kappaB><NFKB><Nitric Oxide><Nitric Oxide Pathway><Nitrogen Monoxide><Nitrogen Protoxide><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Nucleotides><Organism><Pathway interactions><Patients><Phosphotransferase Gene><Phosphotransferases><Photoradiation><Pluripotent Stem Cells><Progenitor Cells><Property><Proteins><Protocol><Protocols documentation><Public Health><RIP2><RIPK2><RIPK2 gene><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Reporter><Reporting><Research><Research Personnel><Researchers><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Sorting><Specific qualifier value><Specified><Stem Cell Development><System><Techniques><Transcription Factor NF-kB><Transgenic Organisms><Translating><Transphosphorylases><Zebra Danio><Zebra Fish><Zebrafish><biological signal transduction><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood progenitor cell expansion><blood progenitor expansion><blood stem cell><blood stem cell emergence><blood stem cell expansion><blood stem cell transplantation><blood treatment><blood-forming stem cell><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell stress><cellular lineage mapping><cellular lineage tracking><complementation><developmental><emergence of hematopoietic stem cells><endothelial cell derived relaxing factor><epigenetic profiling><epigenome profiling><epigenomic profiling><epistatic interaction><epistatic relationship><experiment><experimental research><experimental study><experiments><gene x gene interaction><genetic epistases><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic differentiation><hematopoietic progenitor><hematopoietic progenitor cell expansion><hematopoietic progenitor cell fate><hematopoietic progenitor cell transplantation><hematopoietic progenitor expansion><hematopoietic stem and progenitor cell fate><hematopoietic stem cell emergence><hematopoietic stem cell expansion><hematopoietic stem cell fate><hematopoietic stem cell production><hematopoietic stem progenitor cell><hemogenic endothelium><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><human derived pluripotent stem cell><human pluripotent stem cell><imaging><improved><in utero><in vivo><inflammatory mediator><insight><kappa B Enhancer Binding Protein><leukemia><living system><mutant><notch><notch protein><notch receptors><novel><nuclear factor kappa beta><p65><pathway><pluripotent progenitor><progenitor cell development><progenitor development><receptor><reconstitute><reconstitution><recruit><social role><stem and progenitor cell development><stem cell technology><stem cells><success><tool><transcriptome profiling><transcriptome sequencing><transcriptomic profiling><transcriptomic sequencing><transgenic>
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Erika A Bach

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 52/100
Likely hiring
Solid budget
Active award
$423,750
FY 2026

Project Title

Elucidating mechanisms of spermatogonial stem cell competition

Grant Number:

5R35GM156624-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary The broad, long-term objectives of this application are to characterize mechanisms that allow a competitive germline stem cell (GSC) and its descendants to dominate the GSC population and cause super-Mendelian inheritance. The proposal will determine how a GSC in the Drosophila test...

Research Terms

<Adhesions><Alleles><Allelomorphs><Assay><Basal Transcription Factor><Basal transcription factor genes><Binding Proteins><Bioassay><Biological Assay><Cell Body><Cell-Extracellular Matrix><Cells><Chromatin><Disadvantaged><Disease><Disorder><Drosophila><Drosophila genus><ECM><Extracellular Matrix><Extracellular Matrix Proteins><Fathers><Fostering><Gametes><General Transcription Factor Gene><General Transcription Factors><Genetic><Germ Cells><Germ-Line Cells><Goals><Human><Immunofluorescence><Immunofluorescence Immunologic><Label><Laws><Ligand Binding Protein><Ligand Binding Protein Gene><Modeling><Modern Man><Molecular><Paternal Age><Post-Transcriptional Gene Silencing><Protein Binding><Proteins><Publishing><RNA Interference><RNA Silencing><RNA-Binding Proteins><RNAi><Repression><Reproductive Cells><Research><Role><Sequence-Specific Posttranscriptional Gene Silencing><Sex Cell><Sperm stem cell><Testicles><Testing><Testis><Transcription Factor Proto-Oncogene><Transcription factor genes><Transmission><Tumor Cell><Work><ZNFs><Zn-finger nuclease><adult progenitor><adult stem cell><age associated effects><age effect><age related effects><aging effect><bound protein><cofactor><design><designing><fruit fly><germ stem cells><germline progenitor><germline progenitor cells><germline stem cells><histone H3 methyltransferase><histone methylase><histone methyltransferase><impact of age><influence of age><initial cell><innovate><innovation><innovative><knowledge base><live cell image><live cell imaging><live cellular image><live cellular imaging><mutant><neoplastic cell><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><offspring><perlecan><progenitor cell division><progenitor cell pool><progenitor cell population><progenitor cell renewal><progenitor division><progenitor pool><progenitor population><progenitor renewal><protein expression><recruit><segregation><sexual cell><social role><somatic progenitor><somatic stem cell><sperm progenitor><spermatogonia cell><spermatogonia progenitor><spermatogonia stem cells><spermatogonial cell><spermatogonial progenitor><spermatogonial stem cells><stem and progenitor cell division><stem and progenitor cell population><stem and progenitor cell renewal><stem cell division><stem cell pool><stem cell population><stem cell renewal><stem cells in the germline><transcription factor><transcriptomics><transmission process><zinc finger nuclease><zinc finger nucleases>
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Ian J Davis

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 52/100
Likely hiring
Solid budget
Active award
$422,129
FY 2026

Project Title

Developmental control of chromatin states in cancer

Grant Number:

5R01CA276663-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY Ewing sarcoma, a cancer of the bone and soft tissue of children and young adults, remains a highly lethal cancer despite the use of aggressive chemotherapy, radiation, and surgery. The tumor is dependent on the development of a hybrid gene that brings together parts of two different genes, E...

Research Terms

<0-11 years old><Acceleration><Adolescent><Adolescent Youth><Adolescent and Young Adult><Basal Transcription Factor><Basal transcription factor genes><Binding><Biochemical><Biologic Models><Biological Models><Bone Cancer><Bone Tissue><CRISPR interference><CRISPR-dCas9-mediated repression><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Cancers><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Growth in Number><Cell Multiplication><Cell Physiology><Cell Process><Cell Proliferation><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Proliferation><Characteristics><Child><Child Youth><Childhood Cancers><Children (0-21)><Chimera Protein><Chimeric Proteins><Chromatin><Chromosomal Rearrangement><Chromosomal dislocation><Chromosomal translocation><Clustered Regularly Interspaced Short Palindromic Repeats interference><Common Neoplasm><Common Tumor><Dependence><Development><Differentiation in cell culture><ES cell differentiation><ESC differentiation><ETS Domain><EWS-FLI-1><EWS-FLI1><EWS-FLI1 fusion protein><EWSR1><EWSR1 gene><EWSR2><Enabling Factors><Enhancers><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Ewing Sarcoma Breakpoint Region 1><Ewing Sarcoma Breakpoint Region 2><Ewing's Family of Tumours><Ewing's Sarcoma/Peripheral Primitive Neuroectodermal Tumor><Ewing's Tumor><Ewings sarcoma><FLI1><FLI1 gene><Family member><Fli-1 proto-oncogene, ETS transcription factor><Fostering><Friend leukemia virus integration 1><Functional RNA><Fusion Oncogene Proteins><Fusion Protein><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Generations><Genes><Genetic><Genetic Transcription><Genetic Translocation><Genomics><Growth><HUP1><Heterogeneity><Histologic><Histologically><Histones><Human><Impact evaluation><In vitro cell differentiation><Investigators><Label><Link><Malignant Bone Neoplasm><Malignant Cell><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Neoplasms><Malignant Osseous Neoplasm><Malignant Osseous Tumor><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant Soft Tissue Neoplasm><Malignant Tumor><Malignant Tumor of the Bone><Malignant childhood cancer><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediator><Mesenchymal Cell Neoplasm><Mesenchymal Cell Tumor><Mesenchymal Differentiation><Mesenchymal Neoplasm><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal Tumor><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Microsatellite Markers><Microsatellite Repeats><Microsatellites><Model System><Modern Man><Molecular Interaction><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Oncogene Products><Oncogene Proteins><Oncogenic><Oncoproteins><Operative Procedures><Operative Surgical Procedures><Osseous Cancer><PAX7><PAX7 gene><Paired Box Gene 7><Paired Box Homeotic Gene 7><Paired Domain Gene 7><Pluripotent Stem Cells><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Process><Progenitor Cells><Proliferating><Protein Modification><Proteins><Proteomics><RNA><RNA Expression><RNA Gene Products><Radiation><Regulation><Regulatory Pathway><Research Personnel><Researchers><Ribonucleic Acid><SIC-1><Sarcoma><Site><Subcellular Process><Surgical><Surgical Interventions><Surgical Procedure><Testing><Tissue Growth><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Cell><Untranslated RNA><Variant><Variation><Work><adult youth><cancer cell><cancer in a child><cancer in children><cellular differentiation><chemotherapy><child with cancer><childhood malignancy><chromosome dislocation><chromosome translocation><cofactor><developmental><differentiation in culture><differentiation in embryonic stem cells><differentiation in vitro><embryonic precursor differentiation><embryonic stem cell differentiation><epigenetically><epigenomics><fusion oncoprotein><global gene expression><global transcription profile><histone modification><hybrid gene><in vitro cellular differentiation><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><insight><juvenile><juvenile human><kids><malignancy><malignant soft tissue tumor><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><neoplasm/cancer><neoplastic cell><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><noncoding><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><ontogeny><patient - derived stem cells><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient derived progenitor><patient matched stem cell><patient-derived pluripotent stem cells><pediatric cancer><pediatric malignancy><permissiveness><pluripotent progenitor><progenitor cell differentiation><progenitor cell model><progenitor differentiation><progenitor model><protein function><recruit><repressing CRISPR-dCas9 system><shRNA><short hairpin RNA><small hairpin RNA><soft tissue><stem and progenitor cell model><stem and progenitor differentiation><stem cell based model><stem cell derived model><stem cell differentiation><stem cell model><stem cells><surgery><transcription factor><transcriptome><transcriptomics><tumor><young adult><young adult age><young adulthood><youngster>
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Woojin Han

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 52/100
Likely hiring
Solid budget
Active award
$409,831
FY 2026

Project Title

Engineered Asymmetric Hydrogel for Muscle Stem Cell Polarity and Fate Specification

Grant Number:

5R01AR080616-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT Skeletal muscle stem cell (MuSC) transplantation is emerging as a promising strategy for treating muscle- associated trauma and diseases. However, MuSCs spontaneously lose their “stemness” and engraftment potential in conventional 2D culture, critically limiting their applicability for cell...

Research Terms

<Address><Adhesives><Apical><Assay><Basal lamina><Beta Cadherin-Associated Protein><Beta-1 Catenin><Bioassay><Biochemical><Biocompatible Materials><Biological Assay><Biomaterials><Biomechanics><Biophysics><CUL-2><Cachectic><Cachexia><Cell Body><Cell Communication and Signaling><Cell Culture System><Cell Polarity><Cell Signaling><Cell Survival><Cell Therapy><Cell Viability><Cell division><Cells><Centrosome><Cues><Disease><Disorder><Dystrophin><EGF Receptor><EGFR><ERBB Protein><Economic Burden><Elasticity><Employment><Engineering><Engraftment><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><Ethylenes><Genes><Glycols><HER1><Hydrogels><In Vitro><Integrins><Integrins Extracellular Matrix><Intracellular Communication and Signaling><Life Cycle><Life Cycle Stages><Ligands><Maintenance><Mechanics><Mitotic spindle><Muscle><Muscle Fibers><Muscle Tissue><Muscle satellite cell><Muscular Dystrophies><Myodystrophica><Myodystrophy><Myogenin><Myotubes><Outcomes Research><PRO2286><Patients><Peptides><Physiologic><Physiological><Progenitor Cell Transplantation><Progenitor Cells><Proliferating><Proteins><Receptor Protein><Regenerative Medicine><Regulation><Research><Rhabdomyocyte><Role><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Source><Specific qualifier value><Specified><Stem Cell Transplantation><Stem Cell like><Stem cell transplant><Stretching><System><TGF-alpha Receptor><Testing><Therapeutic><Transforming Growth Factor alpha Receptor><Transplantation><Trauma><Urogastrone Receptor><Voluntary Muscle><adult progenitor><adult stem cell><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging population><beta cat><beta catenin><biological material><biological signal transduction><biomechanical><biophysical foundation><biophysical principles><biophysical sciences><c-erbB-1><c-erbB-1 Protein><cell based intervention><cell engineering><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular engineering><cellular polarity><cellular therapeutic><cellular therapy><combinatorial><design><designing><diol><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><ethene><life course><mechanic><mechanical><mechanical force><mechanical stimulus><mimetics><muscle dystrophy><muscle progenitor><muscle progenitor cell><muscle regeneration><muscle stem cell><muscular><planar cell polarity><population aging><progenitor biology><progenitor capacity><progenitor cell biology><progenitor cell division><progenitor cell expansion><progenitor cell like><progenitor cell niche><progenitor cell renewal><progenitor division><progenitor expansion><progenitor niche><progenitor renewal><progenitor transplantation><progenitor-like><proto-oncogene protein c-erbB-1><receptor><sarcopenia><sarcopenic><satellite cell><segregation><self-renew><self-renewal><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><somatic progenitor><somatic stem cell><stem and progenitor biology><stem and progenitor cell division><stem and progenitor cell expansion><stem and progenitor cell niche><stem and progenitor cell renewal><stem and progenitor cell transplantations><stem cell biology><stem cell characteristics><stem cell division><stem cell expansion><stem cell niche><stem cell renewal><stem cells><stem-like><stemness><transplant><volumetric muscle loss><β-catenin>
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Maria Mikedis

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

Good lead · 52/100
Likely hiring
Solid budget
Active award
$401,250
FY 2026

Project Title

Post-transcriptional regulation of stem and progenitor cell function

Grant Number:

5R35GM156830-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/20/2025

End Date:

12/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT The genome is transmitted from one generation to the next by two highly specialized cell types, sperm and egg. In the adult testis, spermatogonial stem cells continuously produce progenitors that rapidly expand their population (transit-amplify) before undergoing terminal differentiation in...

Research Terms

<21+ years old><ATRA><Ablation><Adult><Adult Human><Affect><Area><Basal Transcription Factor><Basal transcription factor genes><Binding><Body Tissues><Cancers><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cells><Competence><Complex><Data><Fecundability><Fecundity><Fertility><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generations><Genetic><Genetic Transcription><Genome><Goals><Human><Intracellular Communication and Signaling><Knock-out><Knockout><Malignant Neoplasms><Malignant Testicular Neoplasm><Malignant Testicular Tumor><Malignant Tumor><Malignant Tumor of the Testis><Malignant neoplasm of testis><Mediating><Meiosis><Messenger RNA><Methods><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Non-Polyadenylated RNA><Play><Population><Post-Transcriptional Control><Post-Transcriptional Regulation><Process><Progenitor Cells><RNA><RNA Binding><RNA Expression><RNA Gene Products><RNA Splicing><RNA bound><RNA-Binding Proteins><Reproductive Health><Research><Retinoic Acid><Ribonucleic Acid><Role><Shapes><Signal Induction><Signal Transduction><Signal Transduction Systems><Signaling><Sperm><Sperm stem cell><Spermatogenesis><Spermatozoa><Splicing><Testicles><Testicular Cancer><Testing><Testis><Testis Cancer><Tissues><Trans Vitamin A Acid><Transcription><Transcription Factor Proto-Oncogene><Transcription Repressor><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Transcriptional Repressor><Translational Regulation><Translations><Transmission><Tretinoin><Tretinoinum><Upregulation><Vitamin A Acid><Work><adulthood><all-trans-Retinoic Acid><all-trans-Vitamin A acid><biological signal transduction><cell type><cellular differentiation><egg><genetic repressor><insight><life span><lifespan><mRNA><mRNA Degradation><mRNA Transcript Degradation><malignancy><meiotic><neoplasm/cancer><novel><post-transcriptional gene regulation><posttranscriptional><progenitor><progenitor cell function><progenitor function><programs><response><social role><sperm cell><sperm progenitor><spermatogonia cell><spermatogonia progenitor><spermatogonia stem cells><spermatogonial cell><spermatogonial progenitor><spermatogonial stem cells><stem><stem and progenitor cell function><stem and progenitor function><stem cell function><stem cells><trans-Retinoic Acid><transcription factor><translation><transmission process><zoosperm>
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TIM SCHEDL

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 52/100
Likely hiring
Solid budget
Active award
$388,750
FY 2026

Project Title

Control of germline stem cells and the switch to meiotic development in C. elegans

Grant Number:

5R35GM152192-03

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract A key step in animal germ cell development is the switch in fate from stem/progenitor cells to entering meiotic prophase en route to gametogenesis. Disruption of this switch results in infertility and/or aneuploidy. Conserved features of the developmental transition include ...

Research Terms

<Aneuploid><Aneuploidy><Animals><Basic Research><Basic Science><Behavior><Birth Defects><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Cannot achieve a pregnancy><Cell Body><Cell Growth/Cell Cycle><Cells><Chromosomal Synapsis><Chromosome Pairing><Chromosomes><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Defect><Development><Developmental Process><Difficulty conceiving><E3 Ligase><E3 Ubiquitin Ligase><Ethics><Fecundability><Fecundity><Fertility><Gametes><Gametogenesis><Genetic><Genetic Models><Genomics><Germ Cells><Germ Lines><Germ-Line Cells><Goals><Health><Human><Infertility><Investigation><Knowledge><Meiosis><Metabolic Protein Degradation><Mitotic Cell Cycle><Modern Man><Molecular><Organism><Pathway interactions><Post-Transcriptional Control><Post-Transcriptional Regulation><Process><Progenitor Cells><Prophase><Protein Turnover><Proteins><Proteomics><Regulatory Protein Degradation><Repression><Reproductive Cells><Research><Route><Sex Cell><Synapsis><System><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Work><base><bases><developmental><ethical><fertility cessation><fertility loss><genome scale><genome-wide><genomewide><germ stem cells><germline progenitor><germline progenitor cells><germline stem cells><in vivo><infertile><initial cell><living system><meiotic><model organism><mutant><novel><pathway><post-transcriptional gene regulation><progenitor cell fate><progenitor cell regeneration><progenitor cell self renewal><progenitor fate><progenitor regeneration><progenitor self renewal><programs><protein degradation><sexual cell><stem and progenitor cell fate><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell fate><stem cell regeneration><stem cell self renewal><stem cells><stem cells in the germline><transcriptomics><ubiquitin-protein ligase>
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Paul George

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$387,949
FY 2026

Project Title

A Conductive Polymer-Stem Cell System to Augment Endogenous Stroke Repair Mechanisms and Improve Functional Stroke Recovery

Grant Number:

5R01NS126761-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract The ability to promote regeneration of the central nervous system remains elusive. Stroke is a leading cause of death and disability and creates immense burdens on stroke survivors, their caregivers, and society. Although acute stroke care has rapidly progressed over the past decades, only ...

Research Terms

<21+ years old><Ablation><Acute><Adult><Adult Human><Affect><After Care><After-Treatment><Aftercare><Age><Animals><Antibodies><Apoplexy><Array tomography><Biocompatible Materials><Biomaterials><Biomedical Engineering><Body Tissues><Brain><Brain Nervous System><Brain Vascular Accident><CNS Nervous System><Care Givers><Caregivers><Caring><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Clinical Trials><Common Rat Strains><Data><Differentation Markers><Differentiation Antigens><Differentiation Markers><E-stim><Electric Stimulation><Electrophysiology><Electrophysiology (science)><Eligibility><Eligibility Determination><Embolectomy><Encephalon><Environment><Equilibrium><Glycoproteins><Imaging Procedures><Imaging Technics><Imaging Techniques><Immune response><Infarction><Intracellular Communication and Signaling><Investigation><Label><Long-term disability><MGF Stem Cell Factor><Marker Antigens><Mast Cell Growth Factor><Mediating><Medical><Methods><Natural regeneration><Nervous System><Neural Stem Cell><Neuraxis><Neurologic Body System><Neurologic Organ System><Neuronal Differentiation><Neurophysiology / Electrophysiology><Older Population><Pathway interactions><Patients><Play><Polymers><Production><Progenitor Cell Transplantation><Progenitor Cells><Property><Proteins><Protocol Screening><Publishing><Qualifying><Rat><Rats Mammals><Rattus><Recombinants><Recovery><Recovery of Function><Regeneration><Research><Resolution><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><STC-Related Protein><Signal Transduction><Signal Transduction Systems><Signaling><Societies><Staining method><Stains><Stanniocalcin-Related Protein><Statistical Methods><Steel Factor><Stem Cell Factor><Stem Cell Transplantation><Stem cell transplant><Stroke><Survivors><Synapses><Synaptic><System><Techniques><Testing><Therapeutic Studies><Therapy Research><Tissues><Transplantation><United States><Use of New Techniques><Work><acute cerebrovascular accident><acute stroke><adult animal><adult youth><adulthood><advanced age rats><after stroke><aged><aged animal><aged animals><aged rat><aged rats><aged rodent><aged rodents><ages><animal old age><balance><balance function><bio-engineered><bio-engineers><bioengineering><biological engineering><biological material><biological signal transduction><brain attack><brain tissue><c-kit Ligand><cerebral vascular accident><cerebrovascular accident><disability><early clinical trial><early phase clinical trial><elderly animal><elderly rats><elderly rodent><electrophysiological><electrostimulation><endogenous progenitor><endogenous stem cells><functional improvement><functional recovery><geriatric rats><global gene expression><global transcription profile><high dimensionality><host response><immune system response><immunoresponse><improve function><improved><improved functional outcomes><infarct><injured><innovate><innovation><innovative><kit Ligand><mature animal><microscope imaging><microscopic imaging><microscopy imaging><multidisciplinary><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural repair><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new approaches><novel approaches><novel strategies><novel strategy><old animals><old rats><old rodent><older groups><older individuals><older person><paracrine><pathway><pharmacologic><polymer><polymeric><post stroke><post treatment><poststroke><pre-clinical><preclinical><progenitor and neural stem cells><progenitor biology><progenitor cell based therapy><progenitor cell biology><progenitor cell delivery><progenitor cell therapy><progenitor cell treatment><progenitor delivery><progenitor therapy><progenitor transplantation><progenitor treatment><recruit><regenerate><release factor><repair><repaired><resolutions><scaffold><scaffolding><social role><stanniocalcin 2><statistic methods><stem and progenitor biology><stem and progenitor cell therapy><stem and progenitor cell transplantations><stem cell based therapy><stem cell biology><stem cell delivery><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><stroke model><stroke patient><stroke recovery><stroke survivor><stroke therapy><stroke treatment><stroked><strokes><synapse><transcriptome><translational model><transplant><treating stroke><young adult><young adult age><young adulthood>
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Clemens C Cabernard

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$376,659
FY 2026

Project Title

Cell and mechanobiology of Asymmetric Cell Division

Grant Number:

5R35GM148160-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Generating cells with different fates, functions and behaviors is critically important for the development and maintenance of tissues, organs, and multicellular organisms. Cellular diversity can be generated through Asymmetric Cell Division (ACD). Stem cells utilize ACD to create dif...

Research Terms

<Acute><Affect><Behavior><Body Tissues><CNS Nervous System><Cancers><Cell Body><Cell Size><Cell division><Cells><Cellular Matrix><Central Nervous System><Centrosome><Chromatin><Cues><Cytoskeletal System><Cytoskeleton><Defect><Development><Drosophila><Drosophila genus><Flies><Generations><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Interphase><Kinesin><M Phase><MTOC><Maintenance><Malignant Neoplasms><Malignant Tumor><Medical><Microtubule-Organizing Center><Mitosis><Mitosis Stage><Molecular><Myosin II><Myosin Type II><Neural Stem Cell><Neuraxis><Neurodevelopmental Disorder><Neurological Development Disorder><Non-Polyadenylated RNA><Organ><Organelles><Organism><Pathway interactions><Process><Progenitor Cells><Proteins><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Reproducibility><Research><Ribonucleic Acid><Siblings><Sister><Sister Chromatid><Stereotyping><System><Tissues><Transcriptional Control><Transcriptional Regulation><VHH><VHH antibody><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><developmental><fly><fruit fly><imaging in vivo><in vivo><in vivo imaging><innovate><innovation><innovative><interest><intracellular skeleton><live cell image><live cell imaging><live cellular image><live cellular imaging><living system><malignancy><mechanical cue><mechanical signal><nanobodies><nanobody><neoplasm/cancer><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neuroblast><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><non-muscle myosin><nonmuscle myosin><novel><optogenetics><pathway><progenitor and neural stem cells><programs><protein kinase N><public health relevance><rho G-Proteins><rho GTP-Binding Proteins><rho GTPases><rho Protein P21><rho Small GTP-Binding Proteins><sdAb><segregation><single domain antibodies><spatial and temporal><spatial temporal><spatiotemporal><stem cells><superresolution microscopy><tool><transcriptome sequencing><transcriptomic sequencing><tumor><variable heavy chain antibody>
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Jayshree Samanta

UNIVERSITY OF GEORGIA, ATHENS, GA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$372,972
FY 2026

Project Title

Novel Modulators of TGFß1 signaling in regulation of remyelination by neural stem cells

Grant Number:

5R01NS119517-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT Loss of oligodendrocytes gives rise to demyelination, ultimately resulting in axonal degeneration and debilitating clinical outcomes in diseases like Multiple Sclerosis. While remyelination can prevent neurodegeneration, there are currently no approved therapies for promoting remyelination....

Research Terms

<21+ years old><Ablation><Adult><Adult Human><Basal Transcription Factor><Basal transcription factor genes><Binding Sites><Bioinformatics><Biscyclohexanone Oxaldihydrazone><Bone-Derived Transforming Growth Factor><Brain><Brain Nervous System><CD44><CD44 gene><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cells><Choline><Chronic><Clinical><Combining Site><Corpus Callosum><Corpus Callosums><Cuprizone><Data><Demyelinating Diseases><Demyelinating Disorders><Demyelinations><Diet><Disease><Disorder><Disseminated Sclerosis><Encephalon><Exhibits><GLI Family Gene><GLI Family Protein><GLI Protein><GLI gene><GLI1><GLI1 Gene><GLI1 Protein><Gene Expression><General Transcription Factor Gene><General Transcription Factors><Genes><Glioma Associated Oncogene Homolog 1 Protein><Glioma Associated Oncogene Homolog Protein><Glioma-Associated Oncogene Homolog><Glioma-associated oncogene><Glycoproteins><Human><In Vitro><Injections><Intracellular Communication and Signaling><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Lesion><Ligands><LoxP-flanked allele><MDU3><MS patient><Malignant Melanoma><Mediating><Mediator><Melanoma><Mice><Mice Mammals><Milk Growth Factor><Modeling><Modern Man><Molecular><Multiple Sclerosis><Murine><Mus><Nerve Degeneration><Neural Stem Cell><Neuron Degeneration><Non-metastatic><Nonmetastatic><Null Mouse><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Outcome><Pathway interactions><Pgp1><Platelet Transforming Growth Factor><Population Heterogeneity><Promoter Regions><Promotor Regions><RNA Seq><RNA sequencing><RNAseq><Reactive Site><Receptor Protein><Recovery of Function><Regulation><Reporting><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Source><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Testing><Toxin><Transcription Factor Proto-Oncogene><Transcription factor genes><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Work><adulthood><axonal degeneration><biological signal transduction><cell culture><cell cultures><cell type><de-myelinating diseases><de-myelinating disorders><degenerative axon><demyelinate><demyelinating conditions><demyelination diseases><demyelination disorders><diets><differential expression><differentially expressed><diverse populations><dosage><extracellular><floxed><floxed allele><functional recovery><genetic promoter element><genetic promoter sequence><glioma associated oncogene 1><glioma associated oncogene family zinc finger 1><glycoprotein NMB><gpNMB><heterogeneous population><human disease><in vivo><insight><insular sclerosis><multiple sclerosis patient><nerve stem cell><neural degeneration><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodegeneration><neurodegenerative><neurogenic progenitors><neurogenic stem cell><neurological degeneration><neuron progenitors><neuronal degeneration><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><novel><overexpress><overexpression><paracrine><pathway><patients with MS><patients with multiple sclerosis><people with Multiple sclerosis><peripheral blood><population diversity><prevent><preventing><progenitor and neural stem cells><promoter sequence><re-myelinate><re-myelination><receptor><receptor binding><receptor bound><recruit><remyelinate><remyelination><repair><repaired><response><social role><spatial and temporal><spatial temporal><spatiotemporal><subventricular zone><therapeutic target><transcription factor><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><transcriptomics>
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Jun Wu

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 52/100
Likely hiring
Solid budget
Active award
$352,600
FY 2026

Project Title

Dissect the mechanisms underlying interspecies pluripotent stem cell competition

Grant Number:

5R01HD103627-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/18/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Shortage of organs for transplantation is one of the largest unmet medical needs. Researchers are currently working on a variety of ways to increase the number of organs available. Recently, the prospect of producing human organs in animals via interspecies blastocyst comple...

Research Terms

<Animals><Antioncogene Protein p53><Apoptosis><Apoptosis Pathway><Attention><Automobile Driving><Autoregulation><Blastosphere><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Death><Cell Signaling><Cell Survival><Cell Viability><Cells><Cellular Tumor Antigen P53><Chemicals><Chimera><Chimera organism><Chimerism><Co-culture><Cocultivation><Coculture><Coculture Techniques><Common Rat Strains><Competence><Complement><Complement Proteins><Complex><Data><Development><Distant><ERVs><Embryo><Embryoblast><Embryonic><Embryonic Heart><Endogenous Retroviruses><Endothelium><Engraftment><Ensure><Generalized Growth><Generations><Genes><Genetic><Grafting Procedure><Growth><HERVs><HIF 1><HIF-1 protein><HIF1><HIF1 protein><Homeostasis><Human><Human Endogenous Retroviruses><In Vitro><Innate Immune Response><Inner Cell Mass><Intracellular Communication and Signaling><Investigators><KO mice><Kidney><Kidney Urinary System><Knock-out Mice><Knockout Mice><M mulatta><M. mulatta><Macaca mulatta><Macaca rhesus><Medical><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><NFKB3><Nature><Null Mouse><Oncoprotein p53><Organ><Organ Donor><Organ Transplantation><Organ Transplants><Organogenesis><P53><Pancreas><Pancreatic><Phosphoprotein P53><Phosphoprotein pp53><Physiological Homeostasis><Play><Pluripotent Stem Cells><Preimplantation Embryo><Process><Programmed Cell Death><Protein TP53><RELA><RELA gene><RNA Seq><RNA sequencing><RNAseq><Rat><Rats Mammals><Rattus><Research><Research Personnel><Researchers><Rhesus><Rhesus Macaque><Rhesus Monkey><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Source><System><TP53><TP53 gene><TRP53><Thymus><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Tissue Growth><Tissues><Transmission Electron Microscopy><Tumor Protein p53><Tumor Protein p53 Gene><Work><biological signal transduction><blastocyst><blastula><chimeras><comparative><complementation><developmental><disabled><driving><embryo culture><embryo heart><fetal><fitness><global gene expression><global transcription profile><human derived pluripotent stem cell><human pluripotent stem cell><hypoxia inducible factor 1><implantation><improved><in vitro Model><in vivo><innovate><innovation><innovative><necrocytosis><ontogeny><organ allograft><organ graft><organ xenograft><p53 Antigen><p53 Genes><p53 Signaling Pathway><p53 Tumor Suppressor><p65><pluripotency><pluripotent progenitor><pluripotent state><pre-implantation embryo><progenitor cell survival><progenitor survival><protein p53><renal><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem cell survival><success><transcriptome><transcriptome sequencing><transcriptomic sequencing>
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Haiqi Chen

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 52/100
Likely hiring
Solid budget
Active award
$335,537
FY 2026

Project Title

Spatially Resolved, Functional Dissection of the Human Spermatogonial Stem Cell Niche

Grant Number:

5R01HD114698-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/4/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY The functions of human spermatogonial stem cells (SSCs), including self-renewal and differentiation, are required for the constant production of male gametes over a long reproductive lifespan; imbalances in this process directly contribute to infertility or germ cell-derived cancers....

Research Terms

<Basic Research><Basic Science><Body Tissues><C-KIT Gene><CD117><CD117 Antigens><Cancer Patient><Cancers><Cannot achieve a pregnancy><Catalogs><Causality><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell-to-Cell Interaction><Cells><Clinic><Comparative Study><Coupled><DNA Synthesis Factor><Data><Data Set><Difficulty conceiving><Dissection><EDN1><EPLG1><ET-1><Eck Ligand><Eck RPTK Ligand><Endothelial Cell Growth Factor><Endothelin><Endothelin Type 1><Endothelin-1><Endothelium Secreted Protein B61><Endothelium-Derived Vasoconstrictor Factors><Eph Receptor Ligands><Ephrin-A1><Ephrins><Epl1 Protein><Etiology><FGF><FGF Receptors><FGF-R><FGFR><Fecundability><Fecundity><Fertility><Fibroblast Growth Factor><Fibroblast Growth Factor Gene Family><Fibroblast Growth Factor Receptor Family><Fibroblast Growth Factor Receptors><Fibroblast Growth Regulatory Factor><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Foundations><GDNF><GDNF gene><Gametes><Gene Expression><Genetic Models><Germ Cells><Germ-Line Cells><Goals><Health Care><Heterograft><Heterologous Transplantation><Human><In Vitro><Individual><Infertility><Intracellular Communication and Signaling><Knowledge><LERK-1 Protein><Ligands><Male Infertility><Malignant Neoplasms><Malignant Tumor><Maps><Mast Cell Growth Factor Receptor><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Analysis><Murine><Mus><Non-Polyadenylated RNA><Patients><Process><Production><Progenitor Cells><Proto-Oncogene Protein c-kit><RNA><RNA Gene Products><Receptor Protein><Receptor Signaling><Regulation><Reproductive Cells><Research><Ribonucleic Acid><Rodent><Rodentia><Rodents Mammals><Role><SCF Receptor><SCF Receptor Gene><SCFR><Series><Sex Cell><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Somatic Cell><Sperm stem cell><Spermatogenesis><Stem Cell Factor Receptor><Stem Cell Factor Receptor Gene><System><Testicles><Testing><Testis><Therapeutic><Tissues><Translating><Work><Xenograft><Xenograft procedure><Xenotransplantation><biological signal transduction><c kit><c-kit Protein><c-kit Receptor><catalog><causation><cell type><comparative><disease causation><fertility cessation><fertility loss><fertility preservation><flow cytophotometry><genome scale><genome-wide><genomewide><glial cell-line derived neurotrophic factor><human adult stem cell><in vivo><infertile><infertile males><infertile men><infertility in men><initial cell><insight><kit Proto-Oncogene Protein><life span><lifespan><male><male factor infertility><malignancy><men facing infertility><men with infertility><method development><mouse model><murine model><neoplasm/cancer><neurturin><new approaches><novel><novel approaches><novel strategies><novel strategy><nrtn protein><p145(c-kit)><p145c-kit><preserve fertility><progenitor cell expansion><progenitor cell function><progenitor cell niche><progenitor cell regeneration><progenitor cell self renewal><progenitor expansion><progenitor function><progenitor niche><progenitor regeneration><progenitor self renewal><receptor><receptor-mediated signaling><reproductive><self-renew><self-renewal><sexual cell><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><sperm progenitor><spermatogonia cell><spermatogonia progenitor><spermatogonia stem cells><spermatogonial cell><spermatogonial progenitor><spermatogonial stem cells><stem and progenitor cell expansion><stem and progenitor cell function><stem and progenitor cell niche><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor function><stem cell approach><stem cell based approach><stem cell expansion><stem cell function><stem cell method><stem cell methodology><stem cell niche><stem cell procedure><stem cell regeneration><stem cell self renewal><stem cell technique><stem cells><tool><xeno-transplant><xeno-transplantation><♂>
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Hiroshi Nakato

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Good lead · 52/100
Likely hiring
Solid budget
Active award
$329,365
FY 2026

Project Title

Molecular Mechanisms of Regeneration Termination

Grant Number:

5R01HD108059-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary The molecular mechanisms by which stem cell proliferation is precisely controlled during the course of regeneration are poorly understood. Namely, how a damaged tissue senses when to terminate the regeneration process, inactivates stem cell mitotic activity, and organizes ECM integr...

Research Terms

<Actins><Activins><Affect><Ailmentary System><Alimentary System><Autoregulation><Baboons><Bacterial Infections><Beetles><Biologic Models><Biological Models><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell-Extracellular Matrix><Cells><Coleoptera><Complex><Cranin><DNA Helicases><DNA Unwinding Proteins><DNA unwinding enzyme><Data><Digestive System><Drosophila><Drosophila genus><Dystroglycan><Dystrophin><ECM><ECM receptor><Epithelium><Extracellular Matrix><FSH-Releasing Protein><Failure><Filopodia><Foundations><Future><GI Stem cell><Gastrointestinal Body System><Gastrointestinal Organ System><Gene Inactivation><Gene Silencing><Genes><Genetic><Glycoproteins><HSPG><Heparan Sulfate Proteoglycan><High-Risk Cancer><Homeostasis><Integrins><Integrins Extracellular Matrix><Intracellular Communication and Signaling><Knowledge><Link><Mediating><Membrane><Messenger RNA><MicroRNAs><Midgut><Mitotic Activity><Model System><Modeling><Molecular><Natural regeneration><Nature><Order Coleoptera><Organ Size><Papio><Pathway interactions><Phase><Physiological Homeostasis><Process><Progenitor Cells><Proteoheparan Sulfate><RNA Seq><RNA sequencing><RNAseq><Regeneration><Role><Septate><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell Development><Testing><Tissues><Type I Activin Receptor-Like Kinases><Type I Activin Receptors><bacteria infection><bacterial disease><biological signal transduction><design><designing><extracellular matrix receptor><fruit fly><gastrointestinal stem cell><gastrointestinal system><gliotactin><gut progenitor><gut stem cell><helicase><intestinal progenitor><intestinal stem cells><mRNA><member><membrane structure><miRNA><pathway><progenitor cell based therapy><progenitor cell development><progenitor cell function><progenitor cell model><progenitor cell proliferation><progenitor cell therapy><progenitor cell treatment><progenitor development><progenitor function><progenitor model><progenitor proliferation><progenitor therapy><progenitor treatment><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regenerative tissue><response><social role><stem and progenitor cell development><stem and progenitor cell function><stem and progenitor cell model><stem and progenitor cell proliferation><stem and progenitor cell therapy><stem and progenitor function><stem cell based model><stem cell based therapy><stem cell derived model><stem cell function><stem cell mediated therapy><stem cell model><stem cell proliferation><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><syndecan><targeted cancer therapy><tissue regeneration><tissue regrowth><tissue renewal><tissue repair><tissue specific regeneration><tool><transcriptional silencing><transcriptome sequencing><transcriptomic sequencing><tumor>
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Kostandin Pajcini

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 52/100
Likely hiring
Solid budget
Active award
$320,660
FY 2026

Project Title

Notch signaling regulates stem cell function in the fetal liver hematopoietic niche

Grant Number:

5R01DK137093-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

(PLEASE KEEP IN WORD, DO NOT PDF) Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Fetal liver hematopoietic stem cells (HSCs) are capable of rapid proliferation, robust functionality, and enhanced engraftment when u...

Research Terms

<21+ years old><Ablation><Acclimatization><Address><Adult><Adult Human><Affect><Animal Model><Animal Models and Related Studies><Assay><BM Stem Cell><BM derived progenitor><BM progenitor><BM- derived Stem Cells><Bioassay><Biologic Models><Biological><Biological Assay><Biological Models><Biology><Blood Cells><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood Precursor Cell><Blood megakaryocyte><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Marrow Stem Cell><Bone Marrow progenitor><CAP-18><CAP18><CAP18 lipopolysaccharide-binding protein><CBF><CRAMP protein><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cnlp><Complex><Cord Blood><Core-Binding Factor><Cytoplasmic Granules><Data><Developing fetus><Embryo Development><Embryogenesis><Embryonic Development><Engraftment><Family><Family member><Fetal Development><Fetal Liver><Gene Deletion><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Growth><HSC expansion><HSC heterogeneity><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell heterogeneity><Hematopoietic stem cells><Impairment><Intracellular Communication and Signaling><Knowledge><LL37><Label><Ligands><Liver Stem Cell><Marrow Neutrophil><Megakaryocytes><Megalokaryocyte><Methodology><Mice><Mice Mammals><Model System><Multipotent Stem Cells><Murine><Mus><Myelogenous><Myeloid><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Notch Signaling Pathway><Pathway interactions><Peptides><Peripheral Blood Cell><Physiologic><Physiological><Play><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Process><Proliferating><Protein Secretion><Proteins><Proteolysis and Signaling Pathway of Notch><Publishing><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Receptor Activation><Receptor Protein><Recommendation><Rejuvenation><Reporter><Role><Running><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Site><Source><Surface><Testing><Text><Therapeutic><Time><Tissue Growth><Tissues><Transcription><Transgenic Animals><Transgenic Model><Transgenic Organisms><Transplantation><Umbilical Cord Blood><Venus><Visualization><Work><adulthood><aged><aged bone><anti-microbial><antimicrobial><biologic><biological signal transduction><blood cell formation><blood cell progenitor><blood progenitor><blood progenitor cell expansion><blood progenitor expansion><blood stem cell><blood stem cell expansion><blood stem cell heterogeneity><blood-forming stem cell><bone aging><bone marrow derived progenitor><bone marrow derived stem cells><bone marrow stromal cell><bone marrow stromal stem cell><cathelicidin><cathelicidin antimicrobial peptide><cathelin-like protein><cathelin-related antimicrobial peptide><cell type><experiment><experimental research><experimental study><experiments><fetal><fetal cord blood><fetal progenitor><fetal stem cell><fitness><gene deletion mutation><granule><hematopoietic gene><hematopoietic progenitor><hematopoietic progenitor cell expansion><hematopoietic progenitor expansion><hematopoietic stem cell expansion><hematopoietic stem progenitor cell><hemogenic endothelium><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><hepatic progenitor><hepatic stem cell><heterogeneity within hematopoietic stem cells><heterogeneous blood stem cells><heterogeneous hematopoietic stem cells><improved><in vivo><liver development><liver progenitor><model of animal><multipotent progenitor><multipotent progenitor cell><myeloid precursor><myeloid stem and progenitor cell><neutrophil><notch><notch protein><notch receptors><novel><ontogeny><pathway><postnatal><progenitor Cell growth><progenitor cell expansion><progenitor cell function><progenitor cell proliferation><progenitor cell survival><progenitor expansion><progenitor function><progenitor growth><progenitor proliferation><progenitor survival><rapid growth><receptor><reconstitute><reconstitution><rejuvenating intervention><rejuvenation approach><rejuvenation strategies><rejuvenation therapy><rejuvenation treatment><self-renew><self-renewal><single cell analysis><social role><stem and progenitor cell expansion><stem and progenitor cell function><stem and progenitor cell proliferation><stem and progenitor function><stem cell expansion><stem cell function><stem cell growth><stem cell proliferation><stem cell survival><therapeutic rejuvenation><transcriptome sequencing><transcriptomic sequencing><transgenic><transgenic trait><transplant>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Remi J Creusot

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 48/100
Large award
Active award
Team-scale grant
$1,178,188
FY 2026

Project Title

Understanding thymic epithelial and hematopoietic stem cell-intrinsic immune abnormalities driving T1D in optimized HIS mouse models

Grant Number:

5UG3DK142184-02

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary Genetic predisposition to T1D, in addition to HLA, includes >200 non-HLA variants that each add small incremental risk. Inbred NOD mice represent only one genotype and therefore cannot capture diversity imposed by the highly variable human T1D-conferring genotypes. We can replicate t...

Research Terms

<Alleles><Allelomorphs><Allogenic><Antigen-Presenting Cells><Antigens><Autologous><Automobile Driving><Autoregulation><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Beta Cell><Blood Precursor Cell><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Brittle Diabetes Mellitus><CD34><CD34 gene><Capsules><Cell Body><Cells><Cellular biology><Defect><Development><Disease><Disorder><Environmental Factor><Environmental Risk Factor><Family suidae><Gene Modified><Gene variant><Generations><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Genome engineering><Genotype><HPCA1><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Homeostasis><Human><Humulin R><IDDM><Immune><Immune mediated therapy><Immune system><Immunes><Immunodeficient Mouse><Immunologically Directed Therapy><Immunomodulation><Immunotherapy><In Vitro><Inbred NOD Mice><Inducer Cells><Inducer T-Lymphocytes><Infiltration><Inherited Predisposition><Inherited Susceptibility><Insulin><Insulin Cell><Insulin Secreting Cell><Insulin-Dependent Diabetes Mellitus><Interdisciplinary Research><Interdisciplinary Study><Investigation><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Kidney><Kidney Urinary System><Lymphatic Tissue><Lymphoid Tissue><MHC Receptor><Macrophage><Major Histocompatibility Complex Receptor><Methods><Mice><Mice Mammals><Modeling><Modern Man><Mouse Strains><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Myelogenous><Myeloid><Mφ><NOD Mouse><Non-Obese Diabetic Mice><Nonobese Diabetic Mouse><Novolin R><Organoids><Pancreatic beta Cell><Pancreatic β-Cell><Patients><Peripheral><Physiological Homeostasis><Pigs><Predisposition><Progenitor Cells><Recombinant DNA Technology><Regular Insulin><Regulatory T-Lymphocyte><Risk><Risk Factors><Risk-associated variant><Role><Structure of beta Cell of islet><Sudden-Onset Diabetes Mellitus><Suidae><Supporting Cell><Susceptibility><Swine><System><Systems Development><T cell infiltration><T cell response><T-Cell Activation><T-Cell Antigen Receptors><T-Cell Receptor><T-Cells><T-Lymphocyte><T-cell receptor repertoire><T1 DM><T1 diabetes><T1D><T1DM><TCR repertoire><Thymic Tissue><Thymic epithelial cell><Thymocyte Selection><Thymus><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Tissues><Transgenic Organisms><Treg><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Variant><Variation><accessory cell><activate T cells><allelic variant><autoimmune beta cell destruction><autoimmune islet destruction><autoreactive T cell><beta cell autoimmunity><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><capsule><cell biology><developmental><diabetes genetics><diabetes mellitus genetics><diabetes pathogenesis><diabetogenic><driving><environmental risk><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><fetal><gene modification><genetic variant><genetic vulnerability><genetically engineered><genetically modified><genetically predisposed><genomic variant><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><hiPSC><human fetal thymus><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><hypoimmunity><iPS><iPSC><iPSCs><immune deficiency><immune modulation><immune regulation><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunodeficiency><immunogen><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><improved><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><insulin dependent diabetes><insulin dependent type 1><islet><islet autoimmunity><islet cell autoimmunity><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><lymphoid structures><mouse model><murine model><non-obese diabetic (NOD) mice><nonobese diabetic (NOD) mice><novel><pancreas beta cell><pancreas β cell><pancreatic b-cell><porcine><preservation><progenitor biology><progenitor cell biology><regulatory T-cells><renal><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><self-reactive T cell><social role><stem><stem and progenitor biology><stem cell biology><stem cell technology><stem cells><suid><thymus derived lymphocyte><tool><transgenic><type I diabetes><type one diabetes><volunteer><β-cell><β-cells><βCell>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Holger A. Russ

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 48/100
Large award
Active award
Team-scale grant
$1,178,188
FY 2026

Project Title

Understanding thymic epithelial and hematopoietic stem cell-intrinsic immune abnormalities driving T1D in optimized HIS mouse models

Grant Number:

5UG3DK142184-02

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary Genetic predisposition to T1D, in addition to HLA, includes >200 non-HLA variants that each add small incremental risk. Inbred NOD mice represent only one genotype and therefore cannot capture diversity imposed by the highly variable human T1D-conferring genotypes. We can replicate t...

Research Terms

<Alleles><Allelomorphs><Allogenic><Antigen-Presenting Cells><Antigens><Autologous><Automobile Driving><Autoregulation><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Beta Cell><Blood Precursor Cell><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Brittle Diabetes Mellitus><CD34><CD34 gene><Capsules><Cell Body><Cells><Cellular biology><Defect><Development><Disease><Disorder><Environmental Factor><Environmental Risk Factor><Family suidae><Gene Modified><Gene variant><Generations><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Genome engineering><Genotype><HPCA1><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Homeostasis><Human><Humulin R><IDDM><Immune><Immune mediated therapy><Immune system><Immunes><Immunodeficient Mouse><Immunologically Directed Therapy><Immunomodulation><Immunotherapy><In Vitro><Inbred NOD Mice><Inducer Cells><Inducer T-Lymphocytes><Infiltration><Inherited Predisposition><Inherited Susceptibility><Insulin><Insulin Cell><Insulin Secreting Cell><Insulin-Dependent Diabetes Mellitus><Interdisciplinary Research><Interdisciplinary Study><Investigation><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Kidney><Kidney Urinary System><Lymphatic Tissue><Lymphoid Tissue><MHC Receptor><Macrophage><Major Histocompatibility Complex Receptor><Methods><Mice><Mice Mammals><Modeling><Modern Man><Mouse Strains><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Myelogenous><Myeloid><Mφ><NOD Mouse><Non-Obese Diabetic Mice><Nonobese Diabetic Mouse><Novolin R><Organoids><Pancreatic beta Cell><Pancreatic β-Cell><Patients><Peripheral><Physiological Homeostasis><Pigs><Predisposition><Progenitor Cells><Recombinant DNA Technology><Regular Insulin><Regulatory T-Lymphocyte><Risk><Risk Factors><Risk-associated variant><Role><Structure of beta Cell of islet><Sudden-Onset Diabetes Mellitus><Suidae><Supporting Cell><Susceptibility><Swine><System><Systems Development><T cell infiltration><T cell response><T-Cell Activation><T-Cell Antigen Receptors><T-Cell Receptor><T-Cells><T-Lymphocyte><T-cell receptor repertoire><T1 DM><T1 diabetes><T1D><T1DM><TCR repertoire><Thymic Tissue><Thymic epithelial cell><Thymocyte Selection><Thymus><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Tissues><Transgenic Organisms><Treg><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Variant><Variation><accessory cell><activate T cells><allelic variant><autoimmune beta cell destruction><autoimmune islet destruction><autoreactive T cell><beta cell autoimmunity><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><capsule><cell biology><developmental><diabetes genetics><diabetes mellitus genetics><diabetes pathogenesis><diabetogenic><driving><environmental risk><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><fetal><gene modification><genetic variant><genetic vulnerability><genetically engineered><genetically modified><genetically predisposed><genomic variant><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><hiPSC><human fetal thymus><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><hypoimmunity><iPS><iPSC><iPSCs><immune deficiency><immune modulation><immune regulation><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunodeficiency><immunogen><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><improved><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><insulin dependent diabetes><insulin dependent type 1><islet><islet autoimmunity><islet cell autoimmunity><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><lymphoid structures><mouse model><murine model><non-obese diabetic (NOD) mice><nonobese diabetic (NOD) mice><novel><pancreas beta cell><pancreas β cell><pancreatic b-cell><porcine><preservation><progenitor biology><progenitor cell biology><regulatory T-cells><renal><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><self-reactive T cell><social role><stem><stem and progenitor biology><stem cell biology><stem cell technology><stem cells><suid><thymus derived lymphocyte><tool><transgenic><type I diabetes><type one diabetes><volunteer><β-cell><β-cells><βCell>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Megan Sykes

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 48/100
Large award
Active award
Team-scale grant
$1,178,188
FY 2026

Project Title

Understanding thymic epithelial and hematopoietic stem cell-intrinsic immune abnormalities driving T1D in optimized HIS mouse models

Grant Number:

5UG3DK142184-02

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary Genetic predisposition to T1D, in addition to HLA, includes >200 non-HLA variants that each add small incremental risk. Inbred NOD mice represent only one genotype and therefore cannot capture diversity imposed by the highly variable human T1D-conferring genotypes. We can replicate t...

Research Terms

<Alleles><Allelomorphs><Allogenic><Antigen-Presenting Cells><Antigens><Autologous><Automobile Driving><Autoregulation><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Beta Cell><Blood Precursor Cell><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Brittle Diabetes Mellitus><CD34><CD34 gene><Capsules><Cell Body><Cells><Cellular biology><Defect><Development><Disease><Disorder><Environmental Factor><Environmental Risk Factor><Family suidae><Gene Modified><Gene variant><Generations><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Genome engineering><Genotype><HPCA1><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Homeostasis><Human><Humulin R><IDDM><Immune><Immune mediated therapy><Immune system><Immunes><Immunodeficient Mouse><Immunologically Directed Therapy><Immunomodulation><Immunotherapy><In Vitro><Inbred NOD Mice><Inducer Cells><Inducer T-Lymphocytes><Infiltration><Inherited Predisposition><Inherited Susceptibility><Insulin><Insulin Cell><Insulin Secreting Cell><Insulin-Dependent Diabetes Mellitus><Interdisciplinary Research><Interdisciplinary Study><Investigation><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Kidney><Kidney Urinary System><Lymphatic Tissue><Lymphoid Tissue><MHC Receptor><Macrophage><Major Histocompatibility Complex Receptor><Methods><Mice><Mice Mammals><Modeling><Modern Man><Mouse Strains><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><Myelogenous><Myeloid><Mφ><NOD Mouse><Non-Obese Diabetic Mice><Nonobese Diabetic Mouse><Novolin R><Organoids><Pancreatic beta Cell><Pancreatic β-Cell><Patients><Peripheral><Physiological Homeostasis><Pigs><Predisposition><Progenitor Cells><Recombinant DNA Technology><Regular Insulin><Regulatory T-Lymphocyte><Risk><Risk Factors><Risk-associated variant><Role><Structure of beta Cell of islet><Sudden-Onset Diabetes Mellitus><Suidae><Supporting Cell><Susceptibility><Swine><System><Systems Development><T cell infiltration><T cell response><T-Cell Activation><T-Cell Antigen Receptors><T-Cell Receptor><T-Cells><T-Lymphocyte><T-cell receptor repertoire><T1 DM><T1 diabetes><T1D><T1DM><TCR repertoire><Thymic Tissue><Thymic epithelial cell><Thymocyte Selection><Thymus><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Tissues><Transgenic Organisms><Treg><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Variant><Variation><accessory cell><activate T cells><allelic variant><autoimmune beta cell destruction><autoimmune islet destruction><autoreactive T cell><beta cell autoimmunity><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><capsule><cell biology><developmental><diabetes genetics><diabetes mellitus genetics><diabetes pathogenesis><diabetogenic><driving><environmental risk><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><fetal><gene modification><genetic variant><genetic vulnerability><genetically engineered><genetically modified><genetically predisposed><genomic variant><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><hiPSC><human fetal thymus><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><hypoimmunity><iPS><iPSC><iPSCs><immune deficiency><immune modulation><immune regulation><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunodeficiency><immunogen><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><improved><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><insulin dependent diabetes><insulin dependent type 1><islet><islet autoimmunity><islet cell autoimmunity><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><lymphoid structures><mouse model><murine model><non-obese diabetic (NOD) mice><nonobese diabetic (NOD) mice><novel><pancreas beta cell><pancreas β cell><pancreatic b-cell><porcine><preservation><progenitor biology><progenitor cell biology><regulatory T-cells><renal><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><self-reactive T cell><social role><stem><stem and progenitor biology><stem cell biology><stem cell technology><stem cells><suid><thymus derived lymphocyte><tool><transgenic><type I diabetes><type one diabetes><volunteer><β-cell><β-cells><βCell>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

KYLE M LOH

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 48/100
Large award
Active award
Team-scale grant
$1,087,589
FY 2026

Project Title

Stem cell-based modeling of type 1 diabetes to accelerate translation of therapies

Grant Number:

5UG3DK142187-02

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Type 1 diabetes (T1D) is an autoimmune disease with complex underlying genetics and environmental triggers that results in immune-mediated destruction of insulin-producing beta cells. While animal models of spontaneous autoimmune diabetes have provided substantial insights into the pathogen...

Research Terms

<Acceleration><Advanced Development><Alleles><Allelomorphs><Allogenic><Animal Model><Animal Models and Related Studies><Antigen-Presenting Cells><Antigens><Autoantigens><Autoimmune><Autoimmune Diabetes><Autoimmune Diseases><Autoimmune Mechanism><Autoimmune Process><Autoimmune Status><Autoimmunity><Autologous Antigens><Beta Cell><Biologic Models><Biological Models><Blood Precursor Cell><Brittle Diabetes Mellitus><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><Cell Body><Cell Function><Cell Line><Cell Physiology><Cell Process><CellLine><Cells><Cellular Function><Cellular Physiology><Cellular Process><Clonal Expansion><Co-culture><Cocultivation><Coculture><Coculture Techniques><Complex><Development><Disease><Disorder><Engineering><Engraftment><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Gene Modified><Generations><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><HL-A Antigens><HLA Antigens><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Human><Human Leukocyte Antigens><Humulin R><IDDM><Immune><Immune destruction><Immune mediated destruction><Immunes><Immunologic Tests><Immunological Tests><Immunologist><In Vitro><Inflammation><Inflammatory><Inflammatory Response><Insulin><Insulin Cell><Insulin Secreting Cell><Insulin-Dependent Diabetes Mellitus><Investigation><Islands of Langerhans Transplantation><Islands of Pancreas Transplantation><Islet Cell><Islets of Langerhans Grafting><Islets of Langerhans Transplantation><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><LYT3><Leukocyte Antigens><Macrophage><Mediating><Methods><Model System><Modeling><Modern Man><Monitor><Mouse Strains><Mφ><Novolin R><Pancreatic Islets Transplantation><Pancreatic beta Cell><Pancreatic β-Cell><Pathogenesis><Patients><Phase><Pre-Clinical Model><Preclinical Models><Preclinical Testing><Progenitor Cells><Receptor Gene><Recombinant DNA Technology><Reducing Agents><Reductants><Regular Insulin><Research><Role><Self-Antigens><Shapes><Strains Cell Lines><Structure of beta Cell of islet><Subcellular Process><Sudden-Onset Diabetes Mellitus><T Cell Specificity><T-Cell Depletion><T-Cell Immunologic Specificity><T-Cells><T-Lymphocyte><T-cell depletion therapy><T-lymphocyte depletion therapy><T1 DM><T1 diabetes><T1D><T1DM><T4 Cells><T4 Lymphocytes><T8 Cells><T8 Lymphocytes><Technology><Teff cell><Testing><Therapeutic><Therapeutic Agents><Therapeutic Intervention><Transgenic Organisms><Translating><Translations><Transplantation><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Validation><Work><accessory cell><autoimmune attack><autoimmune condition><autoimmune destruction><autoimmune disorder><autoimmune pathogenesis><autoimmune reactivity><autoimmunity disease><autologous islet transplantation><autoreactive T cell><autoreactivity><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cell type><cultured cell line><cytokine><design><designing><developmental><diabetes pathogenesis><effector T cell><engineered T cells><gain of function><gene modification><genetically engineered><genetically engineered T-cells><genetically modified><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><high risk><human derived pluripotent stem cell><human disease><human pluripotent stem cell><human progenitor cell derived><human stem cell-derived><humanized mice><humanized mouse><iPS><iPSC><iPSCs><immunogen><improved><in vitro Assay><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><insulin dependent diabetes><insulin dependent type 1><interest><intervention therapy><islet><islet auto transplantation><islet beta cell transplantation><islet cell transplant><islet cell transplantation><islet transplantation><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><loss of function><model development><model developments><model of animal><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pancreas beta cell><pancreas β cell><pancreatic b-cell><post-transplant><post-transplantation><posttransplant><posttransplantation><pre-clinical research><pre-clinical testing><pre-proinsulin><preclinical research><preproinsulin><preservation><prevent><preventing><progenitor cell function><progenitor cell model><progenitor function><progenitor model><programs><recruit><response><response to therapy><response to treatment><self-reactive T cell><social role><stem and progenitor cell function><stem and progenitor cell model><stem and progenitor function><stem cell based model><stem cell derived model><stem cell function><stem cell model><stem cells><targeted agent><therapeutic agent development><therapeutic development><therapeutic evaluation><therapeutic response><therapeutic testing><therapy response><thymus derived lymphocyte><tool><transgenic><transgenic T- cells><translation><translational therapeutics><translational therapy><transplant><treatment response><treatment responsiveness><type I diabetes><type one diabetes><validations><β-cell><β-cells><βCell>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Audrey Parent

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 48/100
Large award
Active award
Team-scale grant
$1,087,589
FY 2026

Project Title

Stem cell-based modeling of type 1 diabetes to accelerate translation of therapies

Grant Number:

5UG3DK142187-02

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Type 1 diabetes (T1D) is an autoimmune disease with complex underlying genetics and environmental triggers that results in immune-mediated destruction of insulin-producing beta cells. While animal models of spontaneous autoimmune diabetes have provided substantial insights into the pathogen...

Research Terms

<Acceleration><Advanced Development><Alleles><Allelomorphs><Allogenic><Animal Model><Animal Models and Related Studies><Antigen-Presenting Cells><Antigens><Autoantigens><Autoimmune><Autoimmune Diabetes><Autoimmune Diseases><Autoimmune Mechanism><Autoimmune Process><Autoimmune Status><Autoimmunity><Autologous Antigens><Beta Cell><Biologic Models><Biological Models><Blood Precursor Cell><Brittle Diabetes Mellitus><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><Cell Body><Cell Function><Cell Line><Cell Physiology><Cell Process><CellLine><Cells><Cellular Function><Cellular Physiology><Cellular Process><Clonal Expansion><Co-culture><Cocultivation><Coculture><Coculture Techniques><Complex><Development><Disease><Disorder><Engineering><Engraftment><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Gene Modified><Generations><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><HL-A Antigens><HLA Antigens><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Human><Human Leukocyte Antigens><Humulin R><IDDM><Immune><Immune destruction><Immune mediated destruction><Immunes><Immunologic Tests><Immunological Tests><Immunologist><In Vitro><Inflammation><Inflammatory><Inflammatory Response><Insulin><Insulin Cell><Insulin Secreting Cell><Insulin-Dependent Diabetes Mellitus><Investigation><Islands of Langerhans Transplantation><Islands of Pancreas Transplantation><Islet Cell><Islets of Langerhans Grafting><Islets of Langerhans Transplantation><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><LYT3><Leukocyte Antigens><Macrophage><Mediating><Methods><Model System><Modeling><Modern Man><Monitor><Mouse Strains><Mφ><Novolin R><Pancreatic Islets Transplantation><Pancreatic beta Cell><Pancreatic β-Cell><Pathogenesis><Patients><Phase><Pre-Clinical Model><Preclinical Models><Preclinical Testing><Progenitor Cells><Receptor Gene><Recombinant DNA Technology><Reducing Agents><Reductants><Regular Insulin><Research><Role><Self-Antigens><Shapes><Strains Cell Lines><Structure of beta Cell of islet><Subcellular Process><Sudden-Onset Diabetes Mellitus><T Cell Specificity><T-Cell Depletion><T-Cell Immunologic Specificity><T-Cells><T-Lymphocyte><T-cell depletion therapy><T-lymphocyte depletion therapy><T1 DM><T1 diabetes><T1D><T1DM><T4 Cells><T4 Lymphocytes><T8 Cells><T8 Lymphocytes><Technology><Teff cell><Testing><Therapeutic><Therapeutic Agents><Therapeutic Intervention><Transgenic Organisms><Translating><Translations><Transplantation><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Validation><Work><accessory cell><autoimmune attack><autoimmune condition><autoimmune destruction><autoimmune disorder><autoimmune pathogenesis><autoimmune reactivity><autoimmunity disease><autologous islet transplantation><autoreactive T cell><autoreactivity><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cell type><cultured cell line><cytokine><design><designing><developmental><diabetes pathogenesis><effector T cell><engineered T cells><gain of function><gene modification><genetically engineered><genetically engineered T-cells><genetically modified><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><high risk><human derived pluripotent stem cell><human disease><human pluripotent stem cell><human progenitor cell derived><human stem cell-derived><humanized mice><humanized mouse><iPS><iPSC><iPSCs><immunogen><improved><in vitro Assay><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><insulin dependent diabetes><insulin dependent type 1><interest><intervention therapy><islet><islet auto transplantation><islet beta cell transplantation><islet cell transplant><islet cell transplantation><islet transplantation><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><loss of function><model development><model developments><model of animal><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pancreas beta cell><pancreas β cell><pancreatic b-cell><post-transplant><post-transplantation><posttransplant><posttransplantation><pre-clinical research><pre-clinical testing><pre-proinsulin><preclinical research><preproinsulin><preservation><prevent><preventing><progenitor cell function><progenitor cell model><progenitor function><progenitor model><programs><recruit><response><response to therapy><response to treatment><self-reactive T cell><social role><stem and progenitor cell function><stem and progenitor cell model><stem and progenitor function><stem cell based model><stem cell derived model><stem cell function><stem cell model><stem cells><targeted agent><therapeutic agent development><therapeutic development><therapeutic evaluation><therapeutic response><therapeutic testing><therapy response><thymus derived lymphocyte><tool><transgenic><transgenic T- cells><translation><translational therapeutics><translational therapy><transplant><treatment response><treatment responsiveness><type I diabetes><type one diabetes><validations><β-cell><β-cells><βCell>
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Qizhi Tang

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 48/100
Large award
Active award
Team-scale grant
$1,087,589
FY 2026

Project Title

Stem cell-based modeling of type 1 diabetes to accelerate translation of therapies

Grant Number:

5UG3DK142187-02

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Type 1 diabetes (T1D) is an autoimmune disease with complex underlying genetics and environmental triggers that results in immune-mediated destruction of insulin-producing beta cells. While animal models of spontaneous autoimmune diabetes have provided substantial insights into the pathogen...

Research Terms

<Acceleration><Advanced Development><Alleles><Allelomorphs><Allogenic><Animal Model><Animal Models and Related Studies><Antigen-Presenting Cells><Antigens><Autoantigens><Autoimmune><Autoimmune Diabetes><Autoimmune Diseases><Autoimmune Mechanism><Autoimmune Process><Autoimmune Status><Autoimmunity><Autologous Antigens><Beta Cell><Biologic Models><Biological Models><Blood Precursor Cell><Brittle Diabetes Mellitus><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><Cell Body><Cell Function><Cell Line><Cell Physiology><Cell Process><CellLine><Cells><Cellular Function><Cellular Physiology><Cellular Process><Clonal Expansion><Co-culture><Cocultivation><Coculture><Coculture Techniques><Complex><Development><Disease><Disorder><Engineering><Engraftment><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Gene Modified><Generations><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><HL-A Antigens><HLA Antigens><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Human><Human Leukocyte Antigens><Humulin R><IDDM><Immune><Immune destruction><Immune mediated destruction><Immunes><Immunologic Tests><Immunological Tests><Immunologist><In Vitro><Inflammation><Inflammatory><Inflammatory Response><Insulin><Insulin Cell><Insulin Secreting Cell><Insulin-Dependent Diabetes Mellitus><Investigation><Islands of Langerhans Transplantation><Islands of Pancreas Transplantation><Islet Cell><Islets of Langerhans Grafting><Islets of Langerhans Transplantation><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><LYT3><Leukocyte Antigens><Macrophage><Mediating><Methods><Model System><Modeling><Modern Man><Monitor><Mouse Strains><Mφ><Novolin R><Pancreatic Islets Transplantation><Pancreatic beta Cell><Pancreatic β-Cell><Pathogenesis><Patients><Phase><Pre-Clinical Model><Preclinical Models><Preclinical Testing><Progenitor Cells><Receptor Gene><Recombinant DNA Technology><Reducing Agents><Reductants><Regular Insulin><Research><Role><Self-Antigens><Shapes><Strains Cell Lines><Structure of beta Cell of islet><Subcellular Process><Sudden-Onset Diabetes Mellitus><T Cell Specificity><T-Cell Depletion><T-Cell Immunologic Specificity><T-Cells><T-Lymphocyte><T-cell depletion therapy><T-lymphocyte depletion therapy><T1 DM><T1 diabetes><T1D><T1DM><T4 Cells><T4 Lymphocytes><T8 Cells><T8 Lymphocytes><Technology><Teff cell><Testing><Therapeutic><Therapeutic Agents><Therapeutic Intervention><Transgenic Organisms><Translating><Translations><Transplantation><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Validation><Work><accessory cell><autoimmune attack><autoimmune condition><autoimmune destruction><autoimmune disorder><autoimmune pathogenesis><autoimmune reactivity><autoimmunity disease><autologous islet transplantation><autoreactive T cell><autoreactivity><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cell type><cultured cell line><cytokine><design><designing><developmental><diabetes pathogenesis><effector T cell><engineered T cells><gain of function><gene modification><genetically engineered><genetically engineered T-cells><genetically modified><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><high risk><human derived pluripotent stem cell><human disease><human pluripotent stem cell><human progenitor cell derived><human stem cell-derived><humanized mice><humanized mouse><iPS><iPSC><iPSCs><immunogen><improved><in vitro Assay><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><insulin dependent diabetes><insulin dependent type 1><interest><intervention therapy><islet><islet auto transplantation><islet beta cell transplantation><islet cell transplant><islet cell transplantation><islet transplantation><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><loss of function><model development><model developments><model of animal><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pancreas beta cell><pancreas β cell><pancreatic b-cell><post-transplant><post-transplantation><posttransplant><posttransplantation><pre-clinical research><pre-clinical testing><pre-proinsulin><preclinical research><preproinsulin><preservation><prevent><preventing><progenitor cell function><progenitor cell model><progenitor function><progenitor model><programs><recruit><response><response to therapy><response to treatment><self-reactive T cell><social role><stem and progenitor cell function><stem and progenitor cell model><stem and progenitor function><stem cell based model><stem cell derived model><stem cell function><stem cell model><stem cells><targeted agent><therapeutic agent development><therapeutic development><therapeutic evaluation><therapeutic response><therapeutic testing><therapy response><thymus derived lymphocyte><tool><transgenic><transgenic T- cells><translation><translational therapeutics><translational therapy><transplant><treatment response><treatment responsiveness><type I diabetes><type one diabetes><validations><β-cell><β-cells><βCell>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Chris Q Doe

UNIVERSITY OF OREGON, EUGENE, OR

Good lead · 48/100
Likely hiring
Recent
Active award
$236,121
FY 2026

Project Title

Genetic and Molecular Studies of Neurogenesis

Grant Number:

5R01HD027056-34

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/1989

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract The large human cerebral cortex is thought to arise from a specialized population of outer radial glia (oRG) neural stem cells in the outer subventricular zone (OSVZ). These stem cells divide to produce intermediate neural progenitors (INPs) that themselves divide to produce 8-12 neurons. I...

Research Terms

<21+ years old><Address><Adult><Adult Human><Basal Transcription Factor><Basal transcription factor genes><Bees><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Butterflies><Cell Lineage><Cerebral cortex><Complex><Date of birth><Development><Disease><Disorder><Drosophila><Drosophila genus><Encephalon><Encephalon Diseases><Fishes><Flies><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Glia><Glial Cells><Human><Insecta><Insects><Insects Invertebrates><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kolliker's reticulum><Life><Mice><Mice Mammals><Mission><Modeling><Modern Man><Molecular><Murine><Mus><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Non-neuronal cell><Nonneuronal cell><Organoids><Population><Primates><Primates Mammals><Progenitor Cells><Public Health><RNA-Binding Proteins><Radial><Radius><Research><Role><Series><Societies><Specific qualifier value><Specified><System><Testing><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><United States National Institutes of Health><adulthood><brain size><brain tissue><developmental><fetal><fly><fruit fly><glial neural stem cell><glial progenitor><glial stem cell><human progenitor><human stem cells><insight><nerve cement><nerve stem cell><neural><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neuroblast><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuroglial progenitor><neuroglial stem cells><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><progenitor><progenitor and neural stem cells><social role><stem cells><subventricular zone><transcription factor>
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Philip Campbell

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$231,255
FY 2026

Project Title

Mitochondrial mechanisms underlying neural stem and progenitor cell proliferation deficits in 22q11.2 deletion syndrome

Grant Number:

5K08NS135125-03

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Deletion of a region of Chromosome 22q11.2 (22qDS) encoding over 40 protein-coding genes is the most common microdeletion syndrome (~1/2000 live births) and predisposes to multiple neurodevelopmental disorders (NDDs). Individuals with 22qDS display microcephaly and 22qDS mod...

Research Terms

<22q11 Chromosomal Microdeletion Syndrome><22q11 Deletion Syndrome><22q11.2><22q11.2 deletion syndrome><22q11.2DS><22q11DS><ASD><Advisory Committees><Affect><Autism><Autistic Disorder><Autosomal dominant Opitz G/BBB syndrome><Behavior><Behavioral><Brachydanio rerio><Brain><Brain Nervous System><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cayler cardiofacial syndrome><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Cycle Control><Cell Cycle Progression><Cell Cycle Regulation><Cell Division Cycle><Cell Line><Cell Signaling><CellLine><Cells><Chromosomal microdeletion><Chromosome 22><Chromosome 22q11.2 deletion syndrome><Chromosomes><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Communities><Complement><Complement Proteins><Danio rerio><Data><Defect><Development><Di George syndrome><DiGeorge Syndrome><DiGeorge anomaly><DiGeorge sequence><Dysfunction><Early Infantile Autism><Encephalon><Foundations><Functional disorder><Gene Deletion><Gene Transcription><Genes><Genetic><Genetic Transcription><Goals><Heterozygote><Homo><Image><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intracellular Communication and Signaling><Kanner's Syndrome><Lead><Link><Live Birth><Mentorship><Microcephaly><Mitochondria><Mitochondrial Proteins><Modeling><Monitor><Mutate><NGS Method><NGS system><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neural Stem Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Neurosphere><Optics><Organoids><Ortholog><Orthologous Gene><Oxidation-Reduction><Pathogenesis><Pathologic><Pathway interactions><Patients><Pb element><Pennsylvania><Phenotype><Physicians><Physiopathology><Play><Population><Position><Positioning Attribute><Process><Proliferating><Proliferation Marker><Proteins><Psychiatrist><RNA Expression><Redox><Regulation><Reporter Genes><Reporting><Research><Research Resources><Resolution><Resources><Role><Running><Scientist><Sedlackova syndrome><Series><Shprintzen syndrome><Signal Transduction><Signal Transduction Systems><Signaling><Strains Cell Lines><Strategic Planning><Structure><Study models><Syndrome><System><Task Forces><Testing><Therapeutic><Therapeutic Intervention><Training><Transcription><Transgenic Organisms><Universities><Work><Zebra Danio><Zebra Fish><Zebrafish><advisory team><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior phenotype><behavioral phenotyping><biological signal transduction><brain size><brain volume><career><cell type><complementation><conotruncal anomaly face syndrome><cultured cell line><design><designing><developmental><experiment><experimental research><experimental study><experiments><familial third and fourth pharyngeal pouch syndrome><gene complementation><gene deletion mutation><genome editing><genomic editing><heavy metal Pb><heavy metal lead><heterozygosity><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human model><iPS><iPSC><iPSCs><imaging><imaging in vivo><in vivo><in vivo imaging><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><insight><intellectual and developmental disability><intervention therapy><limited intellectual functioning><micrencephaly><microdeletion><microencephaly><mitochondrial><mitochondrial dysfunction><model of human><mouse model><multipotency><multipotent><murine model><mutant><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopment><neurodevelopmental disease><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><next gen sequencing><next generation sequencing><nextgen sequencing><optical><oxidation reduction reaction><pathophysiology><pathway><pharyngeal pouch syndrome><postmitotic><progenitor><progenitor and neural stem cells><progenitor cell model><progenitor cell pool><progenitor cell population><progenitor cell proliferation><progenitor model><progenitor pool><progenitor population><progenitor proliferation><programs><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><resolutions><scRNA sequencing><scRNA-seq><screening><screenings><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><small molecule><social role><stem and progenitor cell model><stem and progenitor cell population><stem and progenitor cell proliferation><stem cell based model><stem cell derived model><stem cell model><stem cell pool><stem cell population><stem cell proliferation><third and fourth pharyngeal pouch syndrome><thymic and parathyroid agenesis syndrome><transgenic><velo-cardio-facial syndrome><velocardiofacial syndrome><velofacial hypoplasia>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Carol H Yan

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$191,873
FY 2026

Project Title

Elucidating Olfactory Epithelial Anti-Viral Responses in Persistent Post-Viral Olfactory Dysfunction

Grant Number:

5K08DC019956-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY: Persistent post-viral olfactory dysfunction (PVOD) is associated with a large spectrum of viruses with significant adverse impacts on quality of life. The molecular and cellular changes in the olfactory epithelium in cases of persistent PVOD have not been well characterized. Specif...

Research Terms

<(IFN) α><(IFN)-α><(IFN)α><2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Address><Alferon><Anosmia><Anti-viral Response><Area><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Basal Cell><Behavior><Body System><Body Tissues><COVID crisis><COVID epidemic><COVID infected patient><COVID pandemic><COVID patient><COVID positive patient><COVID-19><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 infected patient><COVID-19 infection><COVID-19 pandemic><COVID-19 patient><COVID-19 period><COVID-19 positive patient><COVID-19 public health crisis><COVID-19 virus><COVID-19 virus infection><COVID-19 years><COVID19 infection><COVID19 patient><COVID19 positive patient><COVID19 virus><CV-19><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cells><Chronic><Clinical><CoV-2><CoV2><Coronavirus Infectious Disease 2019><Data><Development><Dysfunction><Environment><Functional disorder><Future><Gene Expression><Genes><Grippe><H1N1><H1N1 Virus><HPGF><Hepatocyte-Stimulating Factor><Human><Hybridoma Growth Factor><IFN><IFN Alpha><IFN α><IFN-Gamma><IFN-beta 2><IFN-g><IFN-α><IFN-γ><IFNB2><IFNG><IFNa><IFNα><IFNγ><IL-6><IL6 Protein><Immune Interferon><Immune response><Impairment><In Vitro><In vivo analysis><Individual><Infection><Inflammation><Inflammatory><Influenza><Influenza A><Influenza A Virus, H1N1 Subtype><Influenza A virus><Influenza Virus><Influenza Viruses Type A><Influenzavirus A><Injury><Innate Immune Response><Innate Immune System><Interferon Alfa-n3><Interferon Gamma><Interferon Type I><Interferon Type II><Interferon-α><Interferons><Interleukin-6><Intracellular Communication and Signaling><Knowledge><Leukocyte Interferon><Light><Lineage Tracing><Link><Lymphoblast Interferon><Lymphoblastoid Interferon><MGI-2><Maps><Measures><Mediating><Mice><Mice Mammals><Modern Man><Molecular><Mucosa><Mucosal Tissue><Mucous Membrane><Mucous body substance><Mucus><Murine><Mus><Myeloid Differentiation-Inducing Protein><Natural regeneration><Notch Signaling Pathway><Olfaction><Olfactory Epithelial Cell><Olfactory Epithelium><Olfactory Mucosa><Olfactory Pathways><Olfactory dysfunction><Olfactory system><Organ System><Orthomyxovirus Type A><Outcome><Pathway interactions><Peripheral><Photoradiation><Physiopathology><Plasmacytoma Growth Factor><Population><Progenitor Cells><Proliferating><Proteolysis and Signaling Pathway of Notch><QOL><Quality of life><RNA Seq><RNA sequencing><RNAseq><Regeneration><Research><Resting progenitor><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 infected patient><SARS-CoV-2 infection><SARS-CoV-2 pandemic><SARS-CoV-2 patient><SARS-CoV-2 positive patient><SARS-CoV2><SARS-CoV2 infection><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 infection><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome related corona virus 2><Signal Induction><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Smell><Smell Perception><Testing><Therapeutic><Therapeutic Effect><Tissues><Translating><Translations><Treatment Efficacy><Type A Influenza><Undifferentiated><Upregulation><Viral><Viral Diseases><Virus><Virus Diseases><WNT Signaling Pathway><WNT signaling><Wuhan coronavirus><anosphrasia><antagonism><antagonist><biological signal transduction><cell behavior><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell regeneration><cellular behavior><cellular differentiation><cellular lineage mapping><cellular lineage tracking><cellular regeneration><compare to control><comparison control><coronavirus disease 2019><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 infected patient><coronavirus disease 2019 infection><coronavirus disease 2019 pandemic><coronavirus disease 2019 patient><coronavirus disease 2019 positive patient><coronavirus disease 2019 public health crisis><coronavirus disease 2019 virus><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease infected patient><coronavirus disease pandemic><coronavirus disease patient><coronavirus disease positive patient><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 patient><coronavirus disease-19 virus><coronavirus infectious disease-19><coronavirus patient><cytokine><developmental><dormant stem cell><epithelium regeneration><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><hCoV19><host response><human model><immune system response><immunoresponse><in vivo><in vivo evaluation><in vivo testing><inactive stem cell><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><infection with SARS-CoV-2><influenzavirus><inhibitor><injuries><interest><interferon beta 2><intervention efficacy><lFN-Gamma><latent progenitor><latent stem cell><loss of smell><model of human><mouse model><mucous><murine model><nCoV2><neurogenesis><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><notch><notch protein><notch receptors><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><odor perception><olfactory circuitry><olfactory circuits><olfactory impairment><olfactory loss><olfactory neurogenesis><olfactory perception><olfactory sensory neurons><pathophysiology><pathway><patient infected with COVID><patient infected with COVID-19><patient infected with SARS-CoV-2><patient infected with coronavirus disease><patient infected with coronavirus disease 2019><patient infected with severe acute respiratory syndrome coronavirus 2><patient with COVID><patient with COVID-19><patient with COVID19><patient with SARS-CoV-2><patient with coronavirus disease><patient with coronavirus disease 2019><patient with severe acute respiratory distress syndrome coronavirus 2><progenitor cell differentiation><progenitor cell pool><progenitor cell population><progenitor cell proliferation><progenitor differentiation><progenitor pool><progenitor population><progenitor proliferation><quiescent progenitor><quiescent stem cells><regenerate><regenerate epithelium><response><resting stem cell><scRNA sequencing><scRNA-seq><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 infected patient><severe acute respiratory syndrome coronavirus 2 patient><severe acute respiratory syndrome coronavirus 2 positive patient><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell population><stem and progenitor cell proliferation><stem and progenitor differentiation><stem cell differentiation><stem cell pool><stem cell population><stem cell proliferation><stem cell quiescence><stem cells><therapeutic efficacy><therapeutic target><therapy efficacy><transcriptome profiling><transcriptome sequencing><transcriptomic profiling><transcriptomic sequencing><translation><viral infection><virus infection><virus-induced disease>
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Sharon A Singh

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$169,560
FY 2026

Project Title

The role of Rpl5 haploinsufficiency in hematopoietic stem/progenitor cell function in Diamond Blackfan anemia

Grant Number:

5K08DK127013-05

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Anemia is an extraordinarily common condition that affects approximately 1 in 3 people around the globe. Erythropoiesis is exquisitely sensitive to both endogenous and exogenous stress, which contributes to this massive global disease burden. Genetic defects in ribosomes tha...

Research Terms

<0-11 years old><0-4 weeks old><2 year old><2 years of age><Active Oxygen><Affect><Age Months><Anemia><Animal Model><Animal Models and Related Studies><Aplastic Anemia><Assay><Basic Research><Basic Science><Bioassay><Biological Assay><Birth><Blood Precursor Cell><Blood Transfusion><Blood erythrocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><CFU-E><Causality><Cell Body><Cell Count><Cell Culture Techniques><Cell Cycle><Cell Cycle Control><Cell Cycle Regulation><Cell Division Cycle><Cell Number><Cells><Cellular Stress><Cellular Stress Response><Cellular biology><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Collaborations><Complex><DNA mutation><Data><Defect><Development><Diamond-Blackfan anemia><Disease><Disease remission><Disorder><Dysfunction><Dysmyelopoietic Syndromes><ERYF1><Education><Educational aspects><Embryo><Embryonic><Environment><Erythrocytes><Erythrocytic><Erythroid Colony-Forming Units><Erythropoiesis><Etiology><Evaluation><Failure><Ferroprotoporphyrin><Fetal Edema><Fetal Hydrops><Functional disorder><Funding><GATA Binding Protein 1><GATA-1><GATA1><GATA1 gene><GATA1 protein><GATA1 transcription factor><GF-1 protein><Gene Proteins><Gene Transcription><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Germ-Line Mutation><Goals><HSC transplantation><Health><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Heme><Hemoglobin><Hereditary Mutation><Heterozygote><Human><Hydrops Fetalis><Immune Cell Activation><In Vitro><Inbred Mouse><Individual><Inherited bone marrow failure><Innate Immune System><Junior Physician><Laboratory Research><Macrocytic Anemia><Marrow erythrocyte><Mediator><Mentors><Mentorship><Mice><Mice Mammals><Michigan><Modeling><Modern Man><Murine><Mus><Mutant Strains Mice><Mutation><Myelodysplastic Disease><Myelodysplastic Syndromes><NF-E1 erythroid-specific transcription factor><NFE1 protein><Neonatal><Newborn Infant><Newborns><Normal Cell><Oxygen Radicals><Parturition><Pathogenesis><Pathway interactions><Patients><Pediatric Hematologist><Pediatric Hematology><Pediatric Oncologist><Penetrance><Persons><Phenotype><Physicians><Physiopathology><Play><Pro-Oxidants><Proerythroblast><Progenitor Cells><Pronormoblasts><Protein Biosynthesis><Protein Deficiency><Protein Gene Products><Proteins><Protoheme><RNA Expression><Reactive Oxygen Species><Red Blood Cells><Red Cell><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Remission><Research><Research Resources><Resolution><Resources><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Ribosomal Proteins><Ribosomes><Role><Scientist><Severities><Smoldering Leukemia><Spontaneous Remission><Stress><Testing><Toxic effect><Toxicities><Training><Transcription><Transcription Factor GATA1><Transfusion><Translations><Transplantation><Universities><Work><age 2><age 2 years><aged 2 years><aged two years><blood cell formation><blood cell progenitor><blood corpuscles><blood progenitor><blood stem cell><blood stem cell transplantation><blood-forming stem cell><bone marrow failure syndrome><burden of disease><burden of illness><career><causation><cell biology><cell culture><cell cultures><cell stress><critical developmental period><critical period><deficiency of protein><design><designing><developmental><disease burden><disease causation><erythroid development><erythroid differentiation><exhaustion><experiment><experimental research><experimental study><experiments><ferroheme><genome mutation><germ-line defect><germline variant><globin transcription factor 1><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><heterozygosity><immune activation><improved><in utero><in vivo><inherited disease of bone marrow failure><kids><life span><lifespan><model of animal><mortality><mouse model><mouse mutant><murine model><mutant><myelodysplasia><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><newborn child><newborn children><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><nuclear factor-erythroid 1><pathophysiology><pathway><patient registry><pediatric><prevent><preventing><progenitor biology><progenitor cell biology><progenitor cell function><progenitor function><protein synthesis><resolutions><social role><stem and progenitor biology><stem and progenitor cell function><stem and progenitor function><stem cell biology><stem cell function><stem cells><transcription factor NFE-1><translation><transplant><two year old><two years of age><youngster>
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Konstantinos Alysandratos

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$162,216
FY 2026

Project Title

Utilizing induced pluripotent stem cells to study the role of alveolar type 2 cell dysfunction in pulmonary fibrosis

Grant Number:

5K08HL163494-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary This proposal details a 5-year career development training program focused on developing a patient-specific induced pluripotent stem cell (iPSC) model system to study the role of alveolar epithelial type 2 (AT2) cell dysfunction at the inception of pulmonary fibrosis (PF). A growing ...

Research Terms

<21+ years old><Adult><Adult Human><Allergy><Alveolar><Biogenesis><Biologic Models><Biological Models><Boston><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Line><CellLine><Cells><Cessation of life><Childhood><Critical Care><DNA mutation><Data><Data Set><Death><Development><Diagnosis><Disease><Disorder><Dysfunction><Epithelium><Esbriet><Event><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fibroblasts><Fibrosing Alveolitis><Fibrosis><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Functional disorder><Future><GWA study><GWAS><Gases><Genes><Genetic Change><Genetic defect><Genetic mutation><Genetic study><Genotype><Goals><Human><Idiopathic Interstitial Pneumonia><Immune><Immunes><Impairment><In Vitro><In vivo analysis><Inflammatory><International><Interstitial Lung Diseases><K-Awards><K-Series Research Career Programs><Literature><Lung><Lung Alveolar Epithelia><Lung Diseases><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lung Tissue Fibrosis><Manuscripts><Medicine><Mentors><Mesenchymal><Mesenchymas><Mesenchyme><Metabolic><Methods><Mitochondria><Model System><Modeling><Modern Man><Morbidity><Morphology><Mutant Strains Mice><Mutation><Ofev><Organoids><Origin of Life><Pathogenesis><Pathogenicity><Pathway interactions><Patients><Phenotype><Physicians><Physiopathology><Pirfenidone><Pluripotent Stem Cells><Population><Preparation><Progenitor Cells><Proteomics><Publishing><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Fibrosis><Recombinants><Regenerative Medicine><Research><Research Career Program><Role><Scientist><Sleep><Strains Cell Lines><Stress><Structure of parenchyma of lung><Syndrome><Systems Biology><Testing><Time><Training><Training Programs><Universities><Variant><Variation><abnormal protein homeostasis><abnormal proteostasis><adulthood><alveolar epithelium><career development><cellular differentiation><cultured cell line><defective proteostasis><developmental><diffuse interstitial pulmonary fibrosis><disease model><disease of the lung><disease risk><disorder model><disorder of the lung><disorder risk><effective therapy><effective treatment><fibrogenesis><fibrosis in the lung><gene locus><genetic locus><genome mutation><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic location><genomic locus><human disease><human model><iPS><iPSC><iPSCs><idiopathic pulmonary fibrosis><in vitro Model><in vivo><in vivo evaluation><in vivo testing><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><lung development><lung disorder><lung fibrosis><lung function decline><meeting><meetings><member><mitochondrial><mitochondrial dysfunction><model of human><molecular phenotype><mortality><mouse model><mouse mutant><murine model><new approaches><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><nintedanib><novel><novel approaches><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><pathophysiology><pathway><pediatric><pluripotent progenitor><preparations><progenitor biology><progenitor cell biology><progenitor cell model><progenitor model><protein homeostasis><protein homeostasis decline><protein homeostasis deficiency><protein homeostasis dysfunction><protein homeostasis failure><protein homeostasis loss><proteostasis><proteostasis decline><proteostasis defect><proteostasis deficiency><proteostasis dysfunction><proteostasis dysregulation><proteostasis failure><proteostasis impairment><proteostasis loss><pulmonary><pulmonary function decline><scRNA sequencing><scRNA-seq><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor biology><stem and progenitor cell model><stem cell based model><stem cell biology><stem cell derived model><stem cell model><stem cells><timeline><transcriptomics><whole genome association analysis><whole genome association study>
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Jing Dong

MEDICAL COLLEGE OF WISCONSIN, MILWAUKEE, WI

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$156,600
FY 2026

Project Title

Prognostic implications of mitochondrial inheritance in myelodysplastic syndromes after stem-cell transplantation

Grant Number:

5K01HL164972-04

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/20/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Myelodysplastic syndromes (MDS) are a heterogenous group of clonal hematopoietic stem cell disorders, characterized by ineffective hematopoiesis and a tendency to progress to acute myeloid leukemia in 30% of the patients. Currently the only curative therapy for MDS is allogeneic hematopoiet...

Research Terms

<AML - Acute Myeloid Leukemia><Acute><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Acute leukemia><Address><Affect><Allogenic><Autoregulation><BS-seq><Bioinformatics><Biological Markers><Bisulfite-based sequencing><Blood Diseases><Blood Precursor Cell><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone marrow failure><Cancer Center><Candidate Disease Gene><Candidate Gene><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Causality><Cell Body><Cells><Chronic GVHD><Chronic Leukemia><Clinical><Clinical Data><Clonal Hematopoietic Stem Cell><Cytogenetics><DNA Content><DNA Index><DNA Methylation><DNA Ploidy><DNA mutation><Data><Decision Making><Disease><Disease-Free Survival><Disorder><Dysmyelopoietic Syndromes><Enrollment><Epidemiologic Methodology><Epidemiologic Methods><Epidemiologic research methodology><Epidemiologic research methods><Epidemiological Methods><Epidemiological Techniques><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Event-Free Survival><Exhibits><Fe element><Future><Gene Transcription><Gene variant><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Transcription><Genetic Variation><Genetic defect><Genetic mutation><Genome><Genomics><Goals><HL-A Antigens><HLA Antigens><HSC transplantation><Haplogroup><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematology><Hematopoietic><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Homeostasis><Human Leukocyte Antigens><Impairment><Individualized risk prediction><Ineffective Hematopoiesis><Inferior><Investigators><Iron><K-Awards><K-Series Research Career Programs><Knowledge><Leukocyte Antigens><Medical><Medicine><Mentors><Methodology><Methods Epidemiology><Methods in epidemiology><Methylation><Mitochondria><Mitochondrial DNA><Mitochondrial Inheritance><Modification><Molecular><Molecular Epidemiology><Morbidity><Morphology><Mutation><Myelodysplastic Disease><Myelodysplastic Syndromes><Nuclear><Outcome><Pathogenesis><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Physiological Homeostasis><Play><Ploidies><Progenitor Cell Transplantation><Prognostic Marker><RNA Expression><Recommendation><Recurrent disease><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Relapse><Relapsed Disease><Research><Research Career Program><Research Personnel><Researchers><Risk><Risk Factors><Risk-Benefit Assessment><Role><Single Base Polymorphism><Single Nucleotide Polymorphism><Smoldering Leukemia><Stem Cell Transplantation><Stem cell transplant><Stratification><Subgroup><System><Technology><Therapeutic><Time><Training><Transcription><Transplantation><Variant><Variation><acute granulocytic leukemia><acute myeloid leukemia><allelic variant><bio-markers><biologic marker><biological heterogeneity><biomarker><bisulfite sequencing><bisulfite-seq><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell transplantation><blood-forming stem cell><career><causation><chromosome complement><chronic graft versus host disease><chronic graft vs host disease><chronic graft vs. host disease><clinical heterogeneity><clone hematopoietic stem cell><curative intervention><curative therapeutic><curative therapy><curative treatments><cytopenia><design><designing><disease causation><enroll><entire genome><epidemiologic><epidemiological><epigenetically><epigenomics><experience><full genome><genetic variant><genome mutation><genome sciences><genome sequencing><genomic data><genomic dataset><genomic science><genomic variant><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem progenitor cell><heme biosynthesis><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><high risk><improved><improved outcome><indel><individual response><individualized response><innovate><innovation><innovative><insertion/deletion><insertion/deletion mutation><malleable risk><mitochondrial><mitochondrial DNA alteration><mitochondrial genome><modifiable risk><mortality><mtDNA><mtDNA alteration><myelodysplasia><new drug target><new druggable target><new marker><new pharmacotherapy target><new therapeutic target><new therapy target><non-genetic><nongenetic><novel><novel biomarker><novel drug target><novel druggable target><novel marker><novel pharmacotherapy target><novel therapeutic target><novel therapy target><outcome prediction><patient oriented outcomes><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><personalized risk prediction><population based><post-transplant><post-transplantation><posttransplant><posttransplantation><precision medicine><precision-based medicine><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><professor><progenitor cell homeostasis><progenitor transplantation><prognosis model><prognostic><prognostic ability><prognostic biomarker><prognostic indicator><prognostic model><prognostic power><prognostic profile><prognostic signature><prognostic utility><prognostic value><programs><relapse risk><response to therapy><response to treatment><risk stratification><risk/benefit ratio><single nucleotide variant><social role><statistics><stem and progenitor cell transplantations><stem cell homeostasis><stratify risk><structural mutation><structural variant><structural variation><therapeutic response><therapy response><transplant><treatment response><treatment responsiveness><whole genome>
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Brisa Palikuqi

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$153,943
FY 2026

Project Title

Investigating the role of endothelial cells in intestinal regeneration and disease

Grant Number:

5K01DK139399-02

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Significance: Intestinal dysfunction leads to diseases of enormous morbidity. Maintenance of intestinal stem cell self-renewal and differentiation is dependent on extrinsic signals from the supporting niche. Despite their abundance in the intestinal stem cell niche, the role of endot...

Research Terms

<21+ years old><3-D><3-Dimensional><3D><Adult><Adult Human><Advisory Committees><Biology><Bleeding><Blood><Blood Reticuloendothelial System><Blood Vessels><Body Tissues><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular biology><Clinical><Colon><Colonic Diseases><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Data><Data Set><Development><Disease><Disorder><Dysfunction><Endothelial Cells><Endothelium><Enrollment><Environment><Epithelial Cells><Epithelium><Equilibrium><Foundations><Functional disorder><GI Stem cell><Gene Transcription><Genetic><Genetic Transcription><Glycoproteins><Goals><Hemorrhage><Human><Immune><Immune response><Immunes><Immunology><Immunomodulation><Impairment><Individual><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Injury><Intestinal><Intestinal Diseases><Intestinal Disorder><Intestines><Intracellular Communication and Signaling><K-Awards><K-Series Research Career Programs><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Laboratories><Lung damage><Lymph><Lymphatic Endothelial Cells><Maintenance><Medicine><Mentors><Mice><Mice Mammals><Modeling><Modern Man><Morbidity><Murine><Mus><Natural regeneration><Null Mouse><Organoids><Outcome><Patients><Phase><Physiopathology><Play><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Principal Investigator><Progenitor Cells><Publications><Publishing><RNA Expression><Recovery><Regeneration><Regenerative Medicine><Reporting><Research><Research Associate><Research Career Program><Rest><Role><Scientific Publication><Signal Transduction><Signal Transduction Systems><Signaling><Sodium Dextran Sulfate><Structure><Task Forces><Techniques><Testing><Tissue Sample><Tissues><Training><Training Programs><Transcription><Upregulation><Vascular Endothelium><Vascularization><Work><adulthood><advisory team><balance><balance function><biological signal transduction><blood loss><bowel><career><career development><cell biology><cell regeneration><cell type><cellular regeneration><colitis-induced dysbiosis><colon disorder><cytotoxic><developmental><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><enroll><epithelial repair><gastrointestinal stem cell><gut progenitor><gut stem cell><healing><high resolution imaging><host response><human model><human tissue><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><improved><inflammatory disease of the intestine><inflammatory disorder of the intestine><injured><injuries><injury recovery><insight><intestinal autoinflammation><intestinal progenitor><intestinal stem cells><intestine disease><intestine disorder><islet><lung injury><lymph channel><lymph vessel><lymphatic channel><lymphatic fluid><lymphatic vessel><model of human><mouse model><murine model><paracrine><pathophysiology><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><progenitor cell function><progenitor cell maintenance><progenitor cell niche><progenitor cell regeneration><progenitor cell self renewal><progenitor function><progenitor maintenance><progenitor niche><progenitor regeneration><progenitor self renewal><programs><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><recovery after injury><recovery following injury><recovery post injury><recruit><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration model><regenerative><regenerative model><repair><repaired><research associates><scRNA sequencing><scRNA-seq><scaffold><scaffolding><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stem and progenitor cell function><stem and progenitor cell niche><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor function><stem cell function><stem cell maintenance><stem cell niche><stem cell regeneration><stem cell self renewal><stem cells><three dimensional><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptomics><vascular>
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Eri Takematsu

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$129,420
FY 2026

Project Title

Regulating Skeletal Stem Cell and Neutrophil Dynamics for Improved Cleft Palate Bone Regeneration by Newly Designed Surrogate Bone Morphogenetic Protein-2

Grant Number:

5K99DE032773-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/12/2025

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Cleft Lip and Palate (CLP) is one of the most frequent birth anomalies, currently treated with autografts from the iliac crest. This approach involves multiple invasive surgeries and suffers from graft failures and high donor site complications. Currently, the only other viable treatment option is B...

Research Terms

<ACTRI><ACVR1><ACVR1 gene><ACVRLK2><ACVRLK3 Gene><ALK2><Activin A Receptor, Type II-Like Kinase 2 Gene><Activin Receptor-Like Kinase 2 Gene><Adverse effects><Affect><Antigen-Antibody Complex><Area><Autograft><Autologous Transplantation><Autotransplant><Award><BMP receptor><BMP-2><BMP-2A><BMP2><BMP2 gene><BMP2A Gene><BMPR-II><BMPR1A><BMPR1A gene><BMPR2><BMPR2 gene><BRK-3 protein><Bacteria><Birth><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Body Tissues><Bone Grafting><Bone Morphogenetic Protein 2 Gene><Bone Morphogenetic Protein 2A Gene><Bone Morphogenetic Protein Gene><Bone Morphogenetic Protein Receptor, Type IA Gene><Bone Morphogenetic Protein Receptor, Type II (Serine/Threonine Kinase) Gene><Bone Morphogenetic Proteins><Bone Regeneration><Bone Resorption><Bone Tissue><Bone Transplantation><Buccal Cavity><Buccal Cavity Head and Neck><Cartilage><Cartilaginous Tissue><Cavitas Oris><Cell Body><Cell Communication><Cell Interaction><Cell-to-Cell Interaction><Cells><Cephalic><Cleft Palate><Clinical><Complication><Coupled><Cranial><Data><Defect><Disparities><Disparity><Effectiveness><Engineering><Ensure><Enzyme Gene><Enzymes><Faculty><Genetic><Goals><Histology><Hypodermis><Immune><Immune Complex><Immune reaction><Immune response><Immunes><In Vitro><Individual><Inferior Maxillary Bone><Inflammation><Inflammatory><Investigation><Investigators><Knowledge><Lead><Live Birth><Location><Mandible><Marrow Neutrophil><Mediating><Mentorship><Meta-Analysis><Mice><Mice Mammals><Mission><Modeling><Mouth><Murine><Mus><NIDCR><NIDR><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><Natural regeneration><Neutrophil Activation><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Operative Procedures><Operative Surgical Procedures><Oral cavity><Osteoclastic Bone Loss><Pain><Painful><Palate><Palate Bone><Parturition><Pb element><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Position><Positioning Attribute><Production><Receptor Protein><Regeneration><Regenerative capacity><Research><Research Personnel><Researchers><Risk><SKR1><Site><Skull><Source><Stimulus><Subcutaneous Tissue><Subcutis><Superficial Fascia><Surgical><Surgical Interventions><Surgical Procedure><Swelling><Tela Subcutanea><Temporomandibular joint arthritis><Time><Tissues><Trauma patient><Type I Gene Activin A Receptor><Universities><VHH><VHH antibody><Variant><Variation><X-ray microtomography><Xray microtomography><autologous graft><autotransplantation><bone><bone healing><bone morphogenetic protein 2><bone morphogenetic protein receptor II><bone morphogenetic protein receptor type II><bone morphogenetic protein receptors><bone morphogenic protein><bone repair><bone transplant><bone wound healing><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><career><cleft lip and palate><cleft lip/palate><cleft palate/lip><congenital anomaly><craniofacial><craniofacial bone><craniofacies><cranium><cytokine><design><designing><environment enrichment><environment enrichment for laboratory animals><environmental enrichment><environmental enrichment for laboratory animals><graft failure><heavy metal Pb><heavy metal lead><host response><immune system response><immunoreaction><immunoresponse><improved><in vivo><infection risk><inflammatory environment><inflammatory milieu><innovate><innovation><innovative><mandibular><micro CT><micro computed tomography><microCT><microtomography><nanobodies><nanobody><native protein drug><neutrophil><osseous wound healing><osteoimmunology><palate repair><palatoplasty><pharmaceutical protein><progenitor biology><progenitor cell biology><protein drug agent><protein-based drug><receptor><receptor expression><regenerate><regenerate bone><regeneration ability><regeneration capacity><regenerative><repair><repair strategy><repaired><response><scRNA sequencing><scRNA-seq><sdAb><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single domain antibodies><single-cell RNA sequencing><skeletal><skeletal progenitor><skeletal progenitor cell><skeletal stem cell><soft tissue><standard care><standard treatment><stem and progenitor biology><stem cell biology><subcutaneous><subdermal><subdermal tissue><success><surgery><therapeutic protein><tool><type II BMP receptor><variable heavy chain antibody>
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Brian Jude Joseph

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$126,900
FY 2026

Project Title

Exploiting RNA biogenesis to accelerate neuronal maturation and model age-related tauopathies

Grant Number:

1K99NS146623-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/7/2026

End Date:

2/29/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

SUMMARY Incurable neurodegenerative diseases are a growing public health crisis. The ability to generate substantial quantities of disease-pertinent neuron types, with and without predisposing mutations, holds great promise for probing disease mechanisms and developing therapies. However, current p...

Research Terms

<21+ years old><4 microtubule binding repeat tau><4 repeat tau pathology><4 repeats tau><4 repeats tauopathies><4R isoform><4R isoform tau><4R tau><4R tau protein><4R tauopathies><4R variant of tau><Acceleration><Adult><Adult Human><Advocate><Age><Aging><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Area><Assay><Automobile Driving><Axon><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biochemical><Biogenesis><Biological Assay><Biology><Brain><Brain Nervous System><Business-Friendly Atmosphere><Cell Body><Cells><Chromatin><Communities><Contracting Opportunities><Contracts><DNA mutation><Data><Degenerative Neurologic Disorders><Development><Disease><Disorder><Electrophysiology><Electrophysiology (science)><Embryo><Embryonic><Encephalon><Environment><Evaluation><Event><Exons><Gene Expression><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Change><Genetic defect><Genetic mutation><Health><Human><In Vitro><Induced pluripotent stem cell derived neurons><Isoforms><Knowledge><Late-Onset Disorder><Link><MAPT gene><MAPT protein><MT-bound tau><MTBT1><Methods><Mice><Mice Mammals><Modeling><Modern Man><Motor><Motor Cell><Motor Neurons><Mouse ES Cell><Mouse ESC><Mouse Embryonic Progenitor><Mouse Embryonic Stem Cells><Murine><Mus><Mutation><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural Development><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Body System><Neurologic Degenerative Conditions><Neurologic Organ System><Neuron Degeneration><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neuronal Differentiation><Neurons><Neurophysiology / Electrophysiology><Non-Polyadenylated RNA><Onset of illness><Origin of Life><Pathology><Pathway interactions><Phenotype><Physiologic><Physiological><Postdoc><Postdoctoral Fellow><Process><Production><Productivity><Progenitor Cells><Protein Isoforms><Protocol><Protocols documentation><Public Health><RNA><RNA Gene Products><RNA Processing><RNA Splicing><Regenerative Medicine><Regulation><Research><Research Associate><Ribonucleic Acid><Specific qualifier value><Specified><Spinal><Splicing><Stem Cell Development><System><Tauopathies><Technical Expertise><Technology><Testing><Training><Transcription Factor Proto-Oncogene><Transcription factor genes><Variant><Variation><Work><adulthood><age associated><age associated disease><age associated disorder><age associated impairment><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age clock><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age linked><age related><age related human disease><age related neurodegeneration><age specific><age-driven neurodegenerative disorders><age-related disease><age-related disorder><age-related impairment><age-related neurodegenerative disease><age-related neurodegenerative disorder><ages><aging associated neurodegeneration><aging associated neurodegenerative disease><aging clocks><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><autosome><business-friendly environment><cell cortex><cell type><clock measuring biological age><clock measuring biological aging><clock of biological aging><collaborative atmosphere><collaborative environment><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><develop therapy><developmental><disease model><disease onset><disorder model><disorder onset><driving><electrophysiological><four repeat tau pathology><four repeat tau tauopathies><four repeats tau><four repeats tauopathies><four-repeat isoform tau><genome mutation><global gene expression><global transcription profile><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human progenitor cell derived><human stem cell-derived><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><improved><in vitro Model><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><inducible pluripotent cell><inducible pluripotent stem cell><insight><interactive atmosphere><interactive environment><interdisciplinary atmosphere><interdisciplinary environment><intervention development><investigate longitudinal><late disease onset><late onset disorder><longitudinal investigation><longitudinal research><mESC><microtubule associated protein tau><microtubule bound tau><microtubule-associated protein tau><microtubule-bound tau><motoneuron><murine ES cells><murine ESC><murine embryonic progenitor><murine embryonic stem cell><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurodevelopment><neurological degeneration><neuronal><neuronal degeneration><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><neuropathologic tau><neuropathological tau><novel><overexpress><overexpression><pathway><patient - derived stem cells><patient derived progenitor><patient matched stem cell><peer-group atmosphere><peer-group environment><post-doc><post-doctoral><post-doctoral trainee><postmitotic><postnatal><progenitor cell development><progenitor cell model><progenitor development><progenitor model><programs><protein function><research associates><stem and progenitor cell development><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stem cell technology><stem cells><study longitudinal><success><survey longitudinal><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau with 4 microtubule binding repeats><tau-4R><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><technical skills><therapy development><tool><transcription factor><transcriptome><transcriptomics><treatment development><τ Proteins>
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Chen Weng

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$126,830
FY 2026

Project Title

Deciphering Determinants of Somatic Evolution with Single-Cell Genealogy

Grant Number:

5K99HG013991-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary / Abstract Somatic cells undergo continuous evolution with heritable modifications through genetic and epigenetic changes, influencing cellular competition and selection. Depicted as a detailed branching lineage map, a cellular genealogy provides an essential scaffold to understand ...

Research Terms

<AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><Advisory Committees><Aging><Architecture><Area><Automobile Driving><Awareness><Bar Codes><Biological><Biology><Blood Precursor Cell><Boston><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas9 screen><Causality><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Children's Hospital><Chromatin><Chromosome Mapping><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Complex><Computational Biology><Coupled><DNA mutation><Data><Data Set><Detection><Development><Development Plans><Disease><Disorder><Engineering><Engineering / Architecture><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Evolution><Family Trees><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Pool><Genealogic Tree><Genealogical Tree><Genealogy><Geneologies><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genomics><Genotype><Goals><Health><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heritability><History><Human><Human Figure><Human body><Individual><Institution><Joints><Knowledge><Leadership><Learning><Leukemic Hematopoietic Stem Cell><Libraries><Lineage Tracing><Link><Linkage Mapping><Maps><Mentorship><Mice><Mice Mammals><Modeling><Modern Man><Modification><Murine><Mus><Mutation><Nature><Neoplasms><Pathologic><Pediatric Hospitals><Phase><Phenotype><Physiologic><Physiological><Play><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Preleukemia><Process><Proliferating><Recording of previous events><Reporting><Research><Research Associate><Resolution><Role><Shapes><Somatic Cell><Somatic Mutation><Structure><Subcellular Process><Survey Instrument><Surveys><System><Task Forces><Time><Total Human and Non-Human Gene Mapping><Training><acute granulocytic leukemia><acute myeloid leukemia><adult progenitor><adult stem cell><advisory team><age associated><age correlated><age dependent><age linked><age related><age specific><barcode><biologic><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cancer progression><candidate identification><career><career development><causation><cell behavior><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular behavior><cellular lineage mapping><cellular lineage tracking><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><clustered regularly interspaced short palindromic repeats screen><computer biology><design><designing><developmental><disease causation><driving><driving force><entire genome><epigenetically><frontier><full genome><functional genomics><genetic mapping><genome mutation><hematopoietic cell clones><hematopoietic progenitor><hematopoietic stem cell clonality><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><histories><in vivo Model><insight><leukemia><leukemic hematopoietic progenitor><leukemic hematopoietic stem and progenitor cells><leukemic transformation><mouse model><multi-modality><multimodality><murine model><natural aging><neoplasia><neoplasm progression><neoplastic growth><neoplastic progression><new approaches><normal aging><normative aging><novel approaches><novel strategies><novel strategy><post-doc><post-doctoral><post-doctoral trainee><progenitor biology><progenitor cell biology><programs><research associates><resolutions><scaffold><scaffolding><single cell genomics><single cell technology><skills><social role><somatic progenitor><somatic stem cell><somatic variant><stem and progenitor biology><stem cell biology><tumor progression><whole genome>
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Tingting Duan

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 48/100
Training-friendly
Very recent
Active award
$87,148
FY 2026

Project Title

Metabolic control of tRNA-mediated translational reprogramming in glioblastoma

Grant Number:

5F32CA284780-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Glioblastoma (GBM) ranks among the most lethal of human cancers. Standard-of-care therapies offer only palliation and molecularly targeted treatments have shown little benefit for patients. The failure to achieve tumor control is partly due to the presence of GBM stem cells (GSCs). These st...

Research Terms

<1H-Purin-6-amine><21+ years old><Adenine><Adult><Adult Human><Affect><Amino Acids><Area><Assay><Autoregulation><Base Pairing><Bioassay><Biological Assay><Brain Cancer><Brain Neoplasia><Brain Neoplasms><Brain Tumors><Cancers><Cell Communication and Signaling><Cell Signaling><Chromatography><Codon><Codon Nucleotides><Cues><Data><Data Set><Dependence><Deposit><Deposition><Development><Disease><Disorder><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Failure><Gene Transcription><Generalized Growth><Genetic Code><Genetic Transcription><Genetic study><Glioblastoma><Glioblastoma stem like cancer cell><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Growth><Homeostasis><Human><Immune><Immunes><In Vitro><Increase lifespan><Individual><Initiation Codon><Initiation Factors><Initiator Codon><Intermediary Metabolism><Intracellular Communication and Signaling><Intratumoral heterogeneity><L-Threonine><Link><Liquid substance><Maintenance><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Brain><Malignant neoplasm of brain><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Messenger RNA><Metabolic Control><Metabolic Processes><Metabolism><Mice><Mice Mammals><Modern Man><Modification><Molecular><Murine><Mus><Neural Stem Cell><Oncogenesis><Oncogenic><Operative Procedures><Operative Surgical Procedures><Patient Care><Patient Care Delivery><Patients><Peptide Initiation Factors><Peptides><Phenotype><Physiological Homeostasis><Population><Process><Prognosis><Proliferating><Protein Biosynthesis><Proteomics><Publishing><RNA Expression><Recurrence><Recurrent><Regulation><Ribo-seq><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Role><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Start Codon><Stem Cell like><Structure><Surgical><Surgical Interventions><Surgical Procedure><Testing><Threonine><Tissue Growth><Transcription><Transfer RNA><Translation Initiation Factor><Translational Initiation Factor><Translational Regulation><Translations><Triplet Codon-Amino Acid Adaptor><Tumor Cell><Vitamin B4><adulthood><aggressive therapy><aggressive treatment><aminoacid><angiogenesis><biological signal transduction><boost longevity><cancer progenitor><cancer progenitor cells><cancer stem cell><cancer stem like cell><care for patients><care of patients><caring for patients><cell type><clinical care><cofactor><design><designing><developmental><dietary restriction><differential expression><differentially expressed><effective therapy><effective treatment><elongating the lifespan><enhance longevity><epigenetically><epitranscriptomics><experiment><experimental research><experimental study><experiments><extend life span><extend lifespan><extend longevity><fluid><foster longevity><glioblastoma cancer stem cell><glioblastoma multiforme><glioblastoma progenitor><glioblastoma stem cell><glioblastoma stem like cell><heterogeneity in tumors><improve lifespan><improve longevity><improved><in vivo><insight><intra-tumoral heterogeneity><intratumor heterogeneity><knock-down><knockdown><lifespan extension><liquid><mRNA><mRNA Translation><malignancy><malignant progenitor><malignant stem cell><model organism><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mutant><neoplasm/cancer><neoplastic cell><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oncogenic progenitor><oncogenic stem cells><ontogeny><palliation><posttranscriptional><progenitor Cell growth><progenitor and neural stem cells><progenitor capacity><progenitor cell like><progenitor cell maintenance><progenitor cell proliferation><progenitor growth><progenitor like cancer cell><progenitor maintenance><progenitor proliferation><progenitor-like><progenitor-like cell><programs><prolong lifespan><prolong longevity><promote lifespan><promote longevity><protein synthesis><restricted diet><ribosome footprint profiling><ribosome profiling><self renewing cell><self-renew><self-renewal><social role><spongioblastoma multiforme><standard of care><stem and progenitor cell proliferation><stem cell characteristics><stem cell growth><stem cell maintenance><stem cell proliferation><stem like cancer cell><stem-like><stem-like cell><stemness><support longevity><surgery><tRNA><tandem mass spectrometry><transcriptional differences><transfer Ribonucleic acids><translation><tumor><tumor growth><tumor heterogeneity><tumor xenograft><tumorigenesis><tumors in the brain>
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Blake C Ebert

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Good lead · 48/100
Training-friendly
Very recent
Active award
$54,538
FY 2026

Project Title

Tet-mediated DNA hydroxylation vs formylation and carboxylation in NSC biology

Grant Number:

5F30HD113183-03

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/16/2024

End Date:

4/15/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT The Ten-Eleven Translocation (Tet1/2/3) family of enzymes promote DNA demethylation and are highly expressed in neural stem cells (NSCs). They catalyze the stepwise oxidization of 5-methylcytosine (5mC) to 5- hydroxymethylcytosine (5hmC), 5-formylcytosine (5fC), and 5-carboxylcytosine (5ca...

Research Terms

<Abscission><Affect><Apoptosis><Apoptosis Pathway><Astrocytes><Astrocytus><Astroglia><Attenuated><Biological><Biology><Body Tissues><Cancers><Categories><Cell Cycle><Cell Division Cycle><Cell Line><CellLine><Characteristics><Clinical><Cytosine><DNA><DNA Binding><DNA Binding Interaction><DNA Methylation Regulation><DNA bound><DNA mutation><Data><Defect><Deoxyribonucleic Acid><Development><Down-Regulation><ES cell><Embryo><Embryonic><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Excision><Extirpation><Family><G-T Mismatch-Specific Thymine DNA Glycosylase><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Genes><Genetic Change><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic defect><Genetic mutation><Genome Mappings><Genomic Segment><Genomics><Glia><Glial Cells><Goals><Human><Hydroxylation><Impairment><In Vitro><Individual><Joints><Knowledge><Kolliker's reticulum><Link><Maintenance><Malignant Neoplasms><Malignant Tumor><Maps><Mediating><Mentorship><Methylation><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neural Development><Neural Stem Cell><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurologic Body System><Neurologic Organ System><Neurological Development Disorder><Neurons><Non-neuronal cell><Nonneuronal cell><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Outcome><Pathway interactions><Phenotype><Physicians><Point Mutation><Process><Progenitor Cell Transplantation><Programmed Cell Death><Proliferating><Proteins><RNA Seq><RNA sequencing><RNAseq><Reader><Recombinant DNA Technology><Removal><Research><Role><Scientist><Self Assessment><Stem Cell Transplantation><Stem cell transplant><Strains Cell Lines><Surgical Removal><Testing><Tet><Tetanus Helper Peptide><Thymine DNA Glycosylase><Thymine Glycol DNA Glycosylase><Thymine Glycol Glycosylase><Tissues><Training><Work><astrocytic glia><attenuate><attenuates><biologic><carboxylate><carboxylation><cell type><craniofacial disorder><cultured cell line><demethylation><developmental><differential expression><differentially expressed><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><epigenetic regulation><epigenetically><genetically engineered><genome mutation><genome scale><genome segment><genome-wide><genomewide><genomic region><human disease><improved><malignancy><multipotency><multipotent><mutant><neoplasm/cancer><nerve cement><nerve stem cell><nervous system development><neural><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopment><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><novel><pathway><prevent><preventing><progenitor and neural stem cells><progenitor biology><progenitor cell biology><progenitor cell gene><progenitor cell regeneration><progenitor cell self renewal><progenitor gene><progenitor regeneration><progenitor self renewal><progenitor transplantation><programs><recruit><resection><self-renew><self-renewal><skills><social role><stem and progenitor biology><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor cell transplantations><stem cell biology><stem cell genes><stem cell of embryonic origin><stem cell regeneration><stem cell self renewal><therapeutic target><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><transcriptomics>
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Jennifer R Judge

TUFTS UNIVERSITY BOSTON, BOSTON, MA

Good lead · 48/100
Training-friendly
Very recent
Active award
$48,594
FY 2026

Project Title

Investigating Fucosylation as a Mediator of Limbal Stem Cell Viability

Grant Number:

5F31EY037580-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Limbal stem cells (LSCs) are crucial for maintaining vision. Limbal Stem Cell Deficiency (LSCD) is a potentially blinding condition caused by the death or dysfunction of LSCs. Pronounced local inflammation is a key component of all LSCD etiologies, and recent work has emphasized a key role ...

Research Terms

<(TNF)-α><Abscission><Address><Affect><Agonist><Alkalies><Anabolism><Automobile Driving><Body Tissues><CD 120a Antigen><CD120a Antigens><Cachectin><Cadaver><Causality><Cause of Death><Cell Body><Cell Coat><Cell Communication and Signaling><Cell Death><Cell Death Induction><Cell Function><Cell Growth in Number><Cell Locomotion><Cell Migration><Cell Movement><Cell Multiplication><Cell Physiology><Cell Process><Cell Proliferation><Cell Signaling><Cell Surface Receptors><Cell Survival><Cell Viability><Cell surface><Cells><Cellular Function><Cellular Migration><Cellular Motility><Cellular Physiology><Cellular Process><Cellular Proliferation><Cessation of life><Closure by Ligation><Cornea><Corneal Injury><Data><Data Set><Death><Deoxygalactose><Disease><Disorder><Dysfunction><Epithelial Cells><Epithelium><Equilibrium><Etiology><Excision><Exhibits><Exposure to><Extirpation><Eye><Eyeball><Foundations><Fucose><Functional disorder><Gene Transcription><Genes><Genetic Transcription><Glycans><Glycobiology><Glycocalyx><Goals><Health><Human><In Vitro><Inflammation><Inflammatory><Intracellular Communication and Signaling><Knowledge><Lectin><Ligation><Macrophage-Derived TNF><Mediating><Mediator><Mentors><Mice><Mice Mammals><Modeling><Modern Man><Modification><Molecular><Monocyte-Derived TNF><Monosaccharides><Murine><Mus><Nature><Outcome><Pathway interactions><Phosphorylation><Physiopathology><Play><Polysaccharides><Population><Position><Positioning Attribute><Predisposition><Progenitor Cells><Protein Phosphorylation><RNA Expression><Receptor Protein><Removal><Research><Risk Factors><Role><Sight><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Sorting><Stress><Structure><Subcellular Process><Supplementation><Surface><Surgical Removal><Susceptibility><TNF><TNF A><TNF Alpha><TNF Receptor p55><TNF gene><TNF-sR55><TNF-α><TNF-α receptor><TNFA><TNFAR><TNFR p60><TNFR, 55-kD><TNFR, 60-kD><TNFR-I><TNFR1><TNFR55><TNFR60><TNFRSF1A><TNFRSF1A Receptor><TNFRSF1A gene><TNFalpha receptor><TNFα><TNFα receptor><Time><Tissues><Transcription><Transplantation><Tumor Necrosis Factor><Tumor Necrosis Factor Receptor 1><Tumor Necrosis Factor Receptor 55><Tumor Necrosis Factor-alpha><Vision><Work><Wound Repair><Wound models><adult tissue stem cell><alpha-Fucose><balance><balance function><biological signal transduction><biosynthesis><cadaveric><cadavers><causation><cell motility><cell type><corneal><corneal epithelial wound healing><corneal healing><corneal regeneration><corneal wound><corneal wound healing><cytokine><dietary><differential expression><differentially expressed><disease causation><driving><experience><human RNA sequencing><human RNA-seq><human disease><improved outcome><in vivo Model><limbal><necrocytosis><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ocular surface><pathophysiology><pathway><preservation><progenitor biology><progenitor cell biology><progenitor cell markers><progenitor cell survival><progenitor markers><progenitor stem cell markers><progenitor survival><receptor><regeneration function><regenerative function><regenerative functionality><resection><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor biology><stem cell biology><stem cell biomarkers><stem cell markers><stem cell survival><stem cells><transcriptional differences><transplant><tumor necrosis factor alpha receptor><tumor necrosis factor receptor 1A><tumor necrosis factor α receptor><visual function><wound healing><wound healing models><wound recovery><wound resolution>
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Michael Poeschla

HARVARD MEDICAL SCHOOL, BOSTON, MA

Good lead · 48/100
Training-friendly
Very recent
Active award
$42,220
FY 2026

Project Title

Interrogating the Clonal Architecture of Human Hematopoiesis by Mitochondrial Lineage Tracing

Grant Number:

5F30HL177958-02

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary During aging, human hematopoietic stem cells decline in function, with consequences including cytopenias, increased risk of blood cancer, and decreased regenerative capacity.1–3 Along with other intrinsic and extrinsic changes, somatic mutations that accumulate in individual stem cel...

Research Terms

<AML1><AMLCR1><ATAC><Address><Age><Aging><Architecture><Attenuated><Automobile Driving><Behavior><Biologic Models><Biological><Biological Models><Blood Precursor Cell><Blood megakaryocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><CBFA2><Cardiovascular Diseases><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clonal Expansion><Clonal Hematopoietic Stem Cell><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Clone Cells><Code><Coding System><Complementary DNA><Complex><DNA><DNA mutation><Deoxyribonucleic Acid><Detection><Disease><Disorder><Dysfunction><Engineering / Architecture><Environment><Familial Platelet Disorder><Functional disorder><Gene Targeting><Gene variant><Genes><Genetic Change><Genetic defect><Genetic mutation><Genome><Germ Lines><Germ-Line Mutation><Goals><Grant><Hematology><Hematopoiesis><Hematopoietic><Hematopoietic Cell Tumor><Hematopoietic Cellular Control Mechanisms><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Progenitor Cells><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Hematopoietic stem cells><Hereditary><Hereditary Mutation><Human><Impairment><Incidence><Individual><Inflammation><Inflammatory><Inherited><Intracellular Communication and Signaling><LPTN><Laboratories><Length><Libraries><Lineage Tracing><Link><Malignant Hematopoietic Neoplasm><Maps><Megakaryocytes><Megalokaryocyte><Methodology><Methods><Mitochondria><Model System><Modern Man><Morbidity><Mutation><Nuclear><Outcome><PEBP2A2><PEBP2aB><Pathway interactions><Patients><Penetrance><Persons><Phenotype><Physiopathology><Population><Process><Progenitor Cells><RUNX1><RUNX1 gene><Regenerative capacity><Research><Resolution><Risk><SCM-1><SCM-1a><SCM1><SCYC1><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Somatic Mutation><Structure><Technology><Variant><Variation><XCL1><XCL1 gene><ages><allelic variant><attenuate><attenuates><biologic><biological signal transduction><blood cancer><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cDNA><cancer of blood><cancer of the blood><cancer risk><cardiovascular disorder><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><clonal expansions in the blood><clonal hematopoiesis><clone hematopoietic stem cell><clones in hematopoietic cells><cytopenia><decline in function><decline in functional status><disease risk><disorder risk><driving><elderly patient><epigenomics><exhaustion><fitness><functional decline><functional status decline><genetic variant><genome mutation><genomic variant><germ-line defect><germline variant><hematopoietic cell clones><hematopoietic progenitor><hematopoietic stem cell clonality><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><inflammatory environment><inflammatory milieu><insight><leukemia><life span><lifespan><mitochondrial><mortality><multiomics><multiple omics><novel><older patient><panomics><pathophysiology><pathway><progenitor cell expansion><progenitor cell function><progenitor expansion><progenitor function><regeneration ability><regeneration capacity><resolutions><response><somatic variant><stem and progenitor cell expansion><stem and progenitor cell function><stem and progenitor function><stem cell expansion><stem cell function><stem cells><transcriptomics><variant detection>
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Amelie Raz

WHITEHEAD INSTITUTE FOR BIOMEDICAL RES, CAMBRIDGE, MA

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$162,800
FY 2026

Project Title

Combinatorial signal integration in the maintenance and renewal of adult germline stem cell fate

Grant Number:

5K99GM154143-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Throughout an organism’s lifetime, adult stem cells (aSCs) play a pivotal role in maintaining tissue homeostasis. aSCs possess the remarkable ability to undergo asymmetric divisions, simultaneously renewing themselves and producing differentiating daughter cells. Unlike aSCs...

Research Terms

<21+ years old><Ablation><Adult><Adult Human><Autoregulation><Behavior><Bioinformatics><Body Tissues><Cancers><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cells><Cessation of life><Competence><Data><Daughter><Death><Drosophila><Drosophila genus><Elements><Enabling Factors><Equilibrium><Expression Signature><Gametes><Gene Expression Profile><Gene Transcription><Genetic><Genetic Transcription><Genomics><Germ Cells><Germ-Line Cells><Homeostasis><Individual><Intracellular Communication and Signaling><Lesion><Ligands><Maintenance><Malignant Neoplasms><Malignant Tumor><Mice><Mice Mammals><Modeling><Murine><Mus><Natural regeneration><Organism><Phase><Physiological Homeostasis><Play><Progenitor Cells><Property><RNA Expression><Regeneration><Regulation><Reproductive Cells><Role><Sex Cell><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Sperm stem cell><Stem Cell like><System><Testing><Tissues><Transcript><Transcription><Upregulation><adult progenitor><adult stem cell><adulthood><balance><balance function><biological signal transduction><cell behavior><cell dedifferentiation><cell type><cellular behavior><cellular differentiation><combinatorial><cyber security><cybersecurity><daughter cell><experiment><experimental research><experimental study><experiments><fruit fly><gene expression pattern><gene expression signature><germ stem cells><germline progenitor><germline progenitor cells><germline stem cells><in vivo><initial cell><internet security><living system><male><malignancy><neoplasm/cancer><novel><preservation><progenitor biology><progenitor capacity><progenitor cell biology><progenitor cell fate><progenitor cell homeostasis><progenitor cell like><progenitor cell maintenance><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor cell regeneration><progenitor cell self renewal><progenitor fate><progenitor maintenance><progenitor niche><progenitor pool><progenitor population><progenitor regeneration><progenitor self renewal><progenitor-like><programs><regenerate><regenerative><restoration><self-renew><self-renewal><sexual cell><social role><somatic progenitor><somatic stem cell><sperm progenitor><spermatogonia cell><spermatogonia progenitor><spermatogonia stem cells><spermatogonial cell><spermatogonial progenitor><spermatogonial stem cells><stem and progenitor biology><stem and progenitor cell fate><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell biology><stem cell characteristics><stem cell fate><stem cell homeostasis><stem cell maintenance><stem cell niche><stem cell pool><stem cell population><stem cell regeneration><stem cell self renewal><stem cells><stem cells in the germline><stem-like><stemness><tool><transcriptional profile><transcriptional signature><♂>
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Farhan H Chowdhury

SOUTHERN ILLINOIS UNIVERSITY CARBONDALE, CARBONDALE, IL

Exploratory lead · 40/100
Above-average budget
Recent
Active award
$556,875
FY 2026

Project Title

Single-molecule approaches to study epiblast stem cell fate decision

Grant Number:

2R15GM140448-02

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2021

End Date:

2/28/2029

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The goal of this proposal is to engineer viscoelastic substrates with embedded ‘Cell-zoo’ structures for efficient mesodermal differentiation and further elucidate the underlying mechanism using RNA sequencing. Tissue and organ failure, whether caused by accidents, sports injury, or ...

Research Terms

<Accidents><Accounting><Address><Aging><Athletic Injuries><Beta Cadherin-Associated Protein><Beta-1 Catenin><Biological Function><Biological Process><Biomanufacturing><Body Tissues><CUL-2><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Lineage><Cell Signaling><Cell-Extracellular Matrix><Cells><Chemicals><Classification><Cold-Insoluble Globulins><Collagen IV><Collagen Type IV><Cues><Data><Differential Gene Expression><ECM><ES cell><Elasticity><Engineering><Environment><Epiblast><Exposure to><Extracellular Matrix><FN1><Fibronectin 1><Fibronectins><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Genes><Germ Layers><Glycoprotein GP-2><Goals><Growth><Health><Health Care Costs><Health Costs><Heterogeneity><Intracellular Communication and Signaling><LETS Proteins><Laboratories><Laminin><Large External Transformation-Sensitive Protein><Left Ventricles><Left ventricular structure><Manuscripts><Mechanics><Mesoderm><Mesoderm Cell><Mesodermal Cell><Methods><Mice><Mice Mammals><Modeling><Molecular><Mouse ES Cell><Mouse ESC><Mouse Embryonic Progenitor><Mouse Embryonic Stem Cells><Murine><Mus><Myocardial><Ontology><Opsonic Glycoprotein><Opsonic alpha(2)SB Glycoprotein><Organ failure><Outcome><PRO2286><Pathway interactions><Pattern><Physiologic><Physiological><Pluripotent Stem Cells><Population><Population Heterogeneity><Progenitor Cells><Property><RNA Seq><RNA sequencing><RNAseq><Regenerative Medicine><Research><Role><Scientific Advances and Accomplishments><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Specific qualifier value><Specified><Sports Injuries><Structure><Students><Surface><Systematics><Techniques><Tissue Engineering><Tissue Growth><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Type IV (Basement Membrane) Collagen><alpha 2-Surface Binding Glycoprotein><analyze gene expression><beta cat><beta catenin><bioengineered tissue><biological signal transduction><biological systems><cell engineering><cell type><cellular differentiation><cellular engineering><constriction><directed differentiation><diverse populations><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><engineered tissue><experiment><experimental research><experimental study><experiments><gene expression analysis><gene expression assay><graduate student><heterogeneous population><innovate><innovation><innovative><insight><interdisciplinary approach><mESC><manufacture><mechanic><mechanical><multidisciplinary approach><murine ES cells><murine ESC><murine embryonic progenitor><murine embryonic stem cell><new approaches><next generation><novel approaches><novel strategies><novel strategy><ontogeny><pathway><pluripotency><pluripotent progenitor><pluripotent state><polyacrylamide><population diversity><progenitor cell differentiation><progenitor cell fate><progenitor differentiation><progenitor fate><scientific accomplishments><scientific advances><self-renew><self-renewal><single cell analysis><single molecule><social role><stem and progenitor cell fate><stem and progenitor differentiation><stem cell differentiation><stem cell fate><stem cell of embryonic origin><stem cells><transcriptional profiling><transcriptome sequencing><transcriptomic sequencing><undergrad><undergraduate><undergraduate student><viscoelasticity><β-catenin>
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Marina Y Konopleva

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$431,970
FY 2026

Project Title

Dual targeting of AML by BCL-2 inhibition and by CD123-directed NK engager/NK cell immune therapies

Grant Number:

1R21CA295428-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SCIENTIFIC ABSTRACT Acute myeloid leukemia (AML) is an aggressive clonal hematologic malignancy characterized by the defects in differentiation of the myeloid lineage, heightened proliferation, and resilience to cell death. Despite recent FDA approvals of several targeted therapies including veneto...

Research Terms

<5 AZC><5-AC><5-Aza-cytidine><5-Azacytidine><AML - Acute Myeloid Leukemia><ASCO><AZC><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Allogenic><American Society of Clinical Oncology><Antigens><Apoptosis><Apoptosis Pathway><Apoptotic><Assay><Azacitidine><Azacytidine><B cell lymphoma 2><B-Cell CLL/Lymphoma 2 Gene><B-Cell Chronic Lymphocytic Leukemia Associated Oncogene><B-cell Leukemia 1><B-cell lymphoma/leukemia-2><BCL><BCL1 Oncogene><BCL2><BCL2 gene><Bcl-2><Bioassay><Biological Assay><Blood><Blood Precursor Cell><Blood Reticuloendothelial System><CD123><CD123 Antigen><CD19><CD19 gene><Cancers><Cell Body><Cell Death><Cell Growth and Maintenance><Cell Line><Cell Maintenance><Cell-Mediated Cytolysis><Cell-Mediated Lympholysis><CellLine><Cells><Cellular Cytotoxicity><Cellular immunotherapy><Clinical><Clinical Trials><Cytogenetics><Cytolysis><Cytotoxic cell><DNA mutation><Data><Defect><Dependence><Disease><Disorder><Dose><Engraftment><FDA approved><Family><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Foundations><Future><Genetic Change><Genetic defect><Genetic mutation><Goals><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><Hematopoietic Cell Tumor><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Progenitor Cells><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Hematopoietic stem cells><Human><IL-15><IL15><IL15 Protein><IL3R><IL3RA><IL3RA gene><IL3RAX><IL3RX><Immune><Immunes><Immunochemistry><Immunologic Subtyping><Immunomodulation><Immunophenotyping><In Vitro><Induction of Apoptosis><Interleukin 3 Receptor Alpha><Interleukin-15><Interleukin-15 Precursor><K lymphocyte><Leukemic Cell><Leukemic Natural Killer Cell><Leukemic progenitor and stem cell><Lymphoblastic Leukemia><Lymphocyte Cytotoxicity><Lymphocytic Leukemia><Lymphocytotoxicity><Lymphoid Leukemia><Lysis><Lytotoxicity><MGC9721><Malignant Cell><Malignant Hematologic Neoplasm><Malignant Hematopoietic Neoplasm><Malignant Neoplasms><Malignant Tumor><Methylation><Mice><Mice Mammals><Mitochondria><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Monitor><Murine><Mus><Mutation><Myelogenous><Myeloid><NK Cells><NK cell immune therapy><NK cell immunotherapy><NK cell therapy><NK cell treatment><NK cell-based immune therapy><NK cell-based immunotherapy><NK cell-based therapy><NK cell-based treatment><NK cellular immunotherapy><NK cellular therapy><NK immunotherapy><NK therapy><NK treatment><Natural Killer Cell Immunotherapy><Natural Killer Cells><Normal Cell><Outcome><PBMC><PDX model><Pathway interactions><Patient derived xenograft><Patients><Peripheral Blood Mononuclear Cell><Phase><Phenotype><Pre-Clinical Model><Preclinical Models><Programmed Cell Death><Proliferating><Protein Family><Recurrent disease><Refractory><Regimen><Relapse><Relapsed Disease><Residual><Residual state><Resistance><Safety><Safety Management><Sampling><Sorting><Stem Cell like><Strains Cell Lines><Surface><T-Cells><T-Lymphocyte><Testing><Therapeutic><Toxic effect><Toxicities><Translating><Treatment Efficacy><Work><acute granulocytic leukemia><acute granulocytic leukemia cell><acute myeloblastic leukemia cell><acute myelocytic leukemia cell><acute myelogenous leukemia cell><acute myeloid leukemia><acute myeloid leukemia cell><acute nonlymphocytic leukemia cell><arm><bcl-2 Genes><blood cancer><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cancer cell><cancer of blood><cancer of the blood><ced9 homolog><cell killing><cell mediated cytotoxicity><cell-based immunotherapy><clinical efficacy><combinatorial><comparative><cultured cell line><cytokine release syndrome><cytokine storm><cytotoxicity><determine efficacy><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><flow cytophotometry><genome mutation><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><immune cell therapy><immune microenvironment><immune modulation><immune regulation><immunogen><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><improved><in vivo><inhibitor><intervention efficacy><ladakamycin><leukemia><leukemia stem/initiating cells><leukemia treatment><leukemic progenitor><leukemic stem cell><leukemic therapy><lymphatic leukemia><lymphogenous leukemia><malignancy><mitochondrial><mitochondrial membrane><mitochondrial metabolism><molecular profile><molecular signature><natural killer cell based immune therapy><natural killer cell based immunotherapy><natural killer cell therapy><natural killer cell treatment><natural killer cell-based therapy><natural killer cellular therapy><natural killer therapy><necrocytosis><neoplasm/cancer><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><overexpress><overexpression><pathway><patient derived xenograft model><pre-clinical efficacy><pre-clinical study><preclinical efficacy><preclinical study><pro-apoptotic protein><progenitor capacity><progenitor cell like><progenitor-like><protein metabolism><refractory cancer><relapse patients><resilience><resilient><resistance to therapy><resistant><resistant cancer><resistant to therapy><response><response biomarker><response markers><response to therapy><response to treatment><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><small molecule><stem cell characteristics><stem-like><stemness><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapeutic resistance><therapeutic response><therapy efficacy><therapy resistant><therapy response><thymus derived lymphocyte><treatment resistance><treatment response><treatment responsiveness><tumor immune microenvironment><tumor-immune system interactions>
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Lorena Maili

STOWERS INSTITUTE FOR MEDICAL RESEARCH, KANSAS CITY, MO

Exploratory lead · 40/100
Training-friendly
Recent
Active award
$84,948
FY 2026

Project Title

The role of rRNA transcription and ribosome biogenesis in neural crest progenitors and stem cells during embryonic and postnatal craniofacial development

Grant Number:

5F32DE033617-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Craniofacial anomalies are the most common malformations present at birth and comprise up to 1/3 of all congenital defects. Most of the craniofacial cartilage, bone and connective tissue are derived from neural crest cells (NCC), a migratory stem and progenitor cell population born during e...

Research Terms

<21+ years old><Abscission><Acrofacial Dysostosis><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Anatomic Sites><Anatomic structures><Anatomy><Apoptosis><Apoptosis Pathway><Area><Assay><Automobile Driving><Autoregulation><Berry syndrome><Berry-Treacher Collins syndrome><Bioassay><Biochemical><Biogenesis><Biological Assay><Birth><Birth Defects><Body Tissues><Bone Tissue><Cartilage><Cartilaginous Tissue><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Cell Body><Cell Compartmentation><Cell Compartmentations><Cell Death><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cells><Cellular Proliferation><Cephalic><Characteristics><Cleft Palate><Clinical><Clinical Management><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Connective Tissue><Cranial><Craniofacial Abnormalities><DNA Polymerase I><DNA Polymerase alpha><DNA-Dependent DNA Polymerase I><DNA-Dependent RNA Polymerase I><Data><Defect><Dental><Development><Differentiation and Growth><ES cell><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Epithelium><Excision><Extirpation><Face><Facial Bones><Financial Hardship><Franceschetti syndrome><Franceschetti-Zwahlen syndrome><Franceschetti-Zwahlen-Klein syndrome><Gene Transcription><Generalized Growth><Generations><Genetic><Genetic Transcription><Growth><Growth and Development><Growth and Development function><HG38><Head><Histology><Homeostasis><Individual><Intestinal><Intestines><Klenow Fragment><Knowledge><LGR5><LGR5 gene><Mandibulofacial Dysostosis><Measurement><Mediating><Mesenchymal><Mesenchymas><Mesenchyme><Metabolic><Mice><Mice Mammals><Microscopy><Molecular><Morphogenesis><Murine><Mus><Mutant Strains Mice><Network Analysis><Neural Crest><Neural Crest Cell><Operative Procedures><Operative Surgical Procedures><Origin of Life><Outcome><Palate><Parturition><Pathway Analysis><Patients><Phase><Phenotype><Physiological Homeostasis><Play><Pol I><Population><Preventative therapy><Preventive therapy><Procedures><Process><Progenitor Cells><Prognosis><Programmed Cell Death><Proliferating><Property><Protein Biosynthesis><Proteins><Proteomics><RNA Expression><RNA Polymerase A><RNA Polymerase I><Removal><Ribo-seq><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Ribosomal RNA><Ribosomes><Role><Skin><Speech><Staining method><Stains><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Tamoxifen><Testing><Thomson complex><Tissue Growth><Tissues><Tongue><Transcription><Translations><Treacher Collins Syndrome><Treacher Collins-Franceschetti syndrome><Villus><Work><X-ray microtomography><Xray microtomography><Zwahlen syndrome><adult progenitor><adult stem cell><adulthood><bilateral facial agenesis><bowel><cell type><craniofacial><craniofacial anomalies><craniofacial defects><craniofacial development><craniofacial disorder><craniofacial malformation><craniofacial structure><craniofacial tissue><craniofacies><developmental><driving><dysostosis mandibulofacialis><economic hardship><economic strain><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><epithelial to mesenchymal transition><face bone structure><faces><facial><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><improved><intestinal crypt><juvenile><juvenile human><malformation><mandibulofacial syndrome><micro CT><micro computed tomography><microCT><microtomography><migration><morphogenetic process><mouse model><mouse mutant><murine model><necrocytosis><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><ossa faciei><palatogenesis><post-natal development><postnatal><postnatal development><prevent><preventing><progenitor><progenitor cell differentiation><progenitor cell maintenance><progenitor cell pool><progenitor cell population><progenitor differentiation><progenitor maintenance><progenitor pool><progenitor population><protein synthesis><psychosocial><rRNA><resection><ribosome footprint profiling><ribosome profiling><ribosomopathy><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skeletal><social role><somatic progenitor><somatic stem cell><stem><stem and progenitor cell population><stem and progenitor differentiation><stem cell differentiation><stem cell maintenance><stem cell of embryonic origin><stem cell pool><stem cell population><stem cells><surgery><transcriptomics><translation>
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Emma Troisi

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 40/100
Training-friendly
Recent
Active award
$50,114
FY 2026

Project Title

Regulation and functions of DNA polymerases in the Drosophila male germline stem cell lineage

Grant Number:

1F31HD121393-01

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

In the process of asymmetric cell division (ACD), two daughter cells with identical genetic information, but distinct fates, result from one cell division. Adult stem cells can undergo ACD to produce one self-renewed stem cell and one differentiating daughter cell. This process allows for important ...

Research Terms

<21+ years old><Ablation><Adult><Adult Human><Affect><Aging><Assay><Autoregulation><Back><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biochemical><Biological Assay><Biology><Body Tissues><Cancer Biology><Cancers><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Cell Body><Cell Death><Cell Differentiation><Cell Differentiation process><Cell Lineage><Cell Reprogramming><Cell division><Cells><Cellular Morphology><Cellular biology><Centrosome><Chronic Disease><Chronic Illness><Communities><Complex><DNA Polymerases><DNA Replication><DNA Synthesis><DNA biosynthesis><DNA replication fork><DNA-Dependent DNA Polymerases><DNA-Directed DNA Polymerase><Data><Degenerative Disorder><Development><Developmental Biology><Dorsum><Drosophila><Drosophila genus><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Experimental Genetics><Expression Signature><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fecundability><Fecundity><Fertility><Flies><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Gene Down-Regulation><Gene Expression Profile><General Transcription Factor Gene><General Transcription Factors><Genetic><Germ Lines><Heterozygote><Histones><Homeostasis><Human><Individual><Lab Findings><Laboratory Finding><M Phase><Malignant Neoplasms><Malignant Tumor><Meiosis><Mentorship><Mitosis><Mitosis Stage><Modern Man><Molecular><Molecular Genetics><Movement><NIH><National Institutes of Health><Natural regeneration><Non-Polyadenylated RNA><Organism><Organism-Level Process><Organismal Process><Pattern><Physiologic Processes><Physiological Homeostasis><Physiological Processes><Polymerase><Process><Progenitor Cells><Proteins><Public Health><RNA><RNA Degradation><RNA Gene Products><Recovery><Regeneration><Regenerative Medicine><Regulation><Regulatory Element><Reporter><Repression><Research><Research Resources><Resources><Ribonucleic Acid><Role><S Period><S phase><Sister Chromatid><Sperm><Sperm stem cell><Spermatozoa><Stem Cell like><Synthesis Period><Synthesis Phase><Testicles><Testing><Testis><Time><Tissues><Trans-Acting Factors><Trans-Activators><Transactivators><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcription Factor Proto-Oncogene><Transcription Repression><Transcription Repressor><Transcription factor genes><Transcriptional Activator/Coactivator><Transcriptional Control><Transcriptional Regulation><Transcriptional Repressor><United States National Institutes of Health><Work><adult progenitor><adult stem cell><adulthood><body movement><candidate identification><career><cell biology><cell dedifferentiation><cell morphology><cellular differentiation><cellular reprogramming><chronic disorder><daughter cell><degenerative condition><degenerative disease><developmental><differential expression><differentially expressed><epigenetically><experiment><experimental research><experimental study><experiments><fly><fruit fly><functional outcomes><gene expression pattern><gene expression signature><gene repression><genetic information><genetic repressor><genomic data><genomic dataset><germ stem cells><germline progenitor><germline progenitor cells><germline stem cells><healing><health goals><heterozygosity><in vivo><indexing><inhibitor><life span><lifespan><living system><male><malignancy><meiotic><necrocytosis><neoplasm/cancer><pharmacologic><progenitor biology><progenitor capacity><progenitor cell biology><progenitor cell division><progenitor cell function><progenitor cell like><progenitor cell renewal><progenitor division><progenitor function><progenitor renewal><progenitor-like><regenerate><regeneration potential><regenerative potential><replication fork><self-renew><self-renewal><social role><somatic progenitor><somatic stem cell><sperm cell><sperm progenitor><spermatogonia cell><spermatogonia progenitor><spermatogonia stem cells><spermatogonial cell><spermatogonial progenitor><spermatogonial stem cells><stem and progenitor biology><stem and progenitor cell division><stem and progenitor cell function><stem and progenitor cell renewal><stem and progenitor function><stem cell biology><stem cell characteristics><stem cell division><stem cell function><stem cell renewal><stem cells><stem cells in the germline><stem-like><stemness><transcription factor><transcriptional differences><transcriptional profile><transcriptional signature><transcriptomics><trend><zoosperm><♂>
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Nirbhayaditya Vaghela

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

Exploratory lead · 40/100
Training-friendly
Recent
Active award
$50,114
FY 2026

Project Title

Deciphering the molecular mechanisms governing cell fate transition and lineage commitment by H3K4me1/2 demethylation

Grant Number:

1F31HD121428-01

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/29/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Epigenetic modifiers govern cell fate transition during animal development and their mutations drive multiple human congenital disorders; however, the molecular mechanisms underlying the roles of epigenetic modifiers in these normal and pathological processes remain poorly u...

Research Terms

<AOF2><ATAC sequencing><ATAC-seq><ATACseq><Abscission><Animals><Assay for Transposase-Accessible Chromatin using sequencing><Biological Function><Biological Process><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancers><Cardiac><Cas nuclease technology><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Shape><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Congenital Disorders><DNA mutation><Data><Defect><Deposit><Deposition><Development><Differentiated Gene><Disease><Disorder><EC 2.1.1><ES cell><ES cell differentiation><ESC differentiation><Embryo><Embryoid bodies><Embryonic><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Essential Genes><Excision><Extirpation><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic Change><Genetic Screening><Genetic Transcription><Genetic defect><Genetic mutation><Genome engineering><Germ Layers><Histone H3><Histones><Human><KDM1A><KDM1A gene><Knock-out><Knockout><Knowledge><L-Lysine><LSD1><Lead><Lysine><Lysine-Specific Demethylase 1><Lysine-Specific Demethylase 1A><Malignant Neoplasms><Malignant Tumor><Methylation><Methyltransferase><Mice><Mice Mammals><Mission><Modern Man><Modification><Molecular><Mouse ES Cell><Mouse ESC><Mouse Embryonic Progenitor><Mouse Embryonic Stem Cells><Murine><Mus><Mutation><NIH><National Institutes of Health><Pathogenesis><Pathologic Processes><Pathological Processes><Pathology><Pb element><Play><Population><Process><Proteins><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Reader><Regenerative Medicine><Regulation><Removal><Research><Role><Specific qualifier value><Specified><Surgical Removal><Testing><Time><Transcription><United States National Institutes of Health><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><cellular differentiation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chromatin modifier><demethylation><developmental><developmental disease><developmental disorder><differentiation in embryonic stem cells><differentiation of pluripotent stem cells><disease model><disorder model><embryo derived stem cell><embryonal stem cells><embryonic precursor differentiation><embryonic progenitor><embryonic stem cell><embryonic stem cell differentiation><epigenetic profiling><epigenetically><epigenome><epigenome profiling><epigenomic profiling><genome mutation><global gene expression><global transcription profile><heavy metal Pb><heavy metal lead><histone demethylase><histone modification><human disease><innovate><innovation><innovative><insight><loss of function><mESC><malignancy><methylase><murine ES cells><murine ESC><murine embryonic progenitor><murine embryonic stem cell><mutant><neoplasm/cancer><novel><pluripotency><pluripotent state><pluripotent stem cell differentiation><precise genome editing><progenitor biology><progenitor cell biology><progenitor cell differentiation><progenitor cell regeneration><progenitor cell self renewal><progenitor differentiation><progenitor regeneration><progenitor self renewal><recruit><regenerative approach><regenerative strategy><regenerative technique><resection><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor biology><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor differentiation><stem cell biology><stem cell differentiation><stem cell of embryonic origin><stem cell regeneration><stem cell self renewal><synergism><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcriptome><transcriptome profiling><transcriptome sequencing><transcriptomic profiling><transcriptomic sequencing><transmethylase>
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Isha Walawalkar

UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, FARMINGTON, CT

Exploratory lead · 40/100
Training-friendly
Recent
Active award
$46,415
FY 2026

Project Title

Investigating how splicing factor homeostasis shapes transcriptomes in pluripotency and differentiation

Grant Number:

1F30GM163345-01

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Splicing factors (SFs) are RNA-binding proteins that regulate alternative splicing (AS), enabling a single gene to produce a variety of mRNA transcripts and corresponding proteins. AS plays an integral role in development, cancer, and aging, and many SFs are essential for embryonic d...

Research Terms

<Adopted><Advanced Cancer><Advanced Malignant Neoplasm><Aging><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Assay><Autoregulation><Basic Research><Basic Science><Binding><Bioassay><Biological Assay><Biological Function><Biological Process><Body Tissues><Buffers><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><Cancers><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Causality><Cell Body><Cell Death><Cell Differentiation><Cell Differentiation process><Cell Line><Cell Survival><Cell Viability><CellLine><Cells><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Communication><Coupled><Custom><DNA seq><DNA sequencing><DNAseq><Data><Development><Disease><Disorder><Dose><Doxycycline><Dropout><Electrophysiology><Electrophysiology (science)><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Embryonic Tissue><Engineering><Etiology><Exons><Feedback><Fellowship><Functional RNA><Future><Gene Expression><Genes><Genomics><Goals><Guide RNA><Heart Muscle Cells><Heart myocyte><Homeostasis><Imaging Procedures><Imaging Technics><Imaging Techniques><Immune Precipitation><Immunofluorescence><Immunofluorescence Immunologic><Immunoprecipitation><In Vitro><Isoforms><Knock-out><Knockout><Libraries><Link><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mediating><Messenger RNA><Mice><Mice Mammals><Modeling><Molecular><Molecular Interaction><Morphology><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Non-Polyadenylated RNA><Non-sense Mediated Decay><Noncoding RNA><Nonsense-Mediated Decay><Nontranslated RNA><Oncogenic><Organism><Phenotype><Physicians><Physiological Homeostasis><Play><Pluripotent Stem Cells><Poison><Process><Protein Isoforms><Proteins><RNA><RNA Gene Products><RNA Seq><RNA Splicing><RNA sequencing><RNA-Binding Proteins><RNAseq><Regenerative Medicine><Regulation><Repression><Ribonucleic Acid><Role><Scientist><Shapes><Site><Specific qualifier value><Specified><Splicing><Stem Cell like><Stop Codon><Strains Cell Lines><Tamoxifen><Termination Codon><Terminator Codon><Therapeutic><Tissue-Specific Splicing><Tissues><Toxic Chemical><Toxic Substance><Training><Transcript><Translating><Translation Stop Signal><Untranslated RNA><Upregulation><Vibramycin><Work><aging process><alpha-6-Deoxyoxytetracycline><cancer cell><cardiomyocyte><career><causation><cell type><cellular differentiation><clinical applicability><clinical application><clustered regularly interspaced short palindromic repeats screen><conditional knock-out><conditional knockout><crosslink><cultured cell line><customs><developmental><developmental disease><developmental disorder><disease causation><electrophysiological><embryo tissue><exon skipping><gRNA><genetic approach><genetic strategy><global gene expression><global transcription profile><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSCs><in vivo><induced Cre><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible Cre><inducible pluripotent cell><inducible pluripotent stem cell><living system><mRNA><malignancy><mouse model><murine model><necrocytosis><neoplasm/cancer><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><noncoding><pluripotency><pluripotent progenitor><pluripotent state><posttranscriptional><premature><prematurity><progenitor and neural stem cells><progenitor biology><progenitor capacity><progenitor cell biology><progenitor cell like><progenitor cell model><progenitor cell survival><progenitor model><progenitor survival><progenitor-like><reverse genetics><social role><stem and progenitor biology><stem and progenitor cell model><stem cell based model><stem cell biology><stem cell characteristics><stem cell derived model><stem cell model><stem cell survival><stem-like><stemness><tomography><toxic compound><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics>
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SOFIA ELENA LUNA

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 40/100
Training-friendly
Recent
Active award
$42,485
FY 2026

Project Title

Engineering hematopoietic stem cells to generate therapeutic antibody secreting B cells

Grant Number:

5F30HL178496-02

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/15/2025

End Date:

8/14/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Hypercholesterolemia is a major public health crisis, underscored by the fact that cardiovascular disease is the leading cause of death globally. The standard treatment for hypercholesterolemia is statins, but more recently effective biologics have emerged, including antibodies targe...

Research Terms

<(TNF)-α><APOE><ASCVD><Adeno-Associated Viruses><Advisory Committees><Antibodies><Antibody Therapy><Apo-E><ApoE protein><Apolipoprotein E><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Autoantibodies><Autoimmune Diseases><Autologous><B blood cells><B cell><B cell receptor><B cell reconstitution><B cells><B-Cell Antigen Receptor><B-Cell Development><B-Cells><B-Lymphocytes><B-cell><Biological Agent><Biological Function><Biological Process><Biological Products><Blood><Blood Circulation><Blood Precursor Cell><Blood Reticuloendothelial System><Bloodstream><CETP><CETP gene><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cachectin><Cardiovascular Diseases><Cas nuclease technology><Cause of Death><Cell Body><Cell Function><Cell Lineage><Cell Physiology><Cell Process><Cell Transplantation><Cell secretion><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Secretion><Cholesterol><Cholesterol Esters><Cholesteryl Esters><Clinic><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><DNA mutation><Data Engineering><Defect><Dependoparvovirus><Dependovirus><Development><Disease><Disorder><Dose><Effectiveness><Engineered Gene><Engineering><Engraftment><Enzyme Gene><Enzymes><Expression Signature><Fellowship><Foundations><Frequencies><Future><Gene Expression Profile><Gene Targeting><Genetic Change><Genetic defect><Genetic mutation><Genome engineering><Genomics><HSC transplantation><Hb SS disease><HbSS disease><Hematologic Body System><Hematologic Organ System><Hematopoietic Body System><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic System><Hematopoietic stem cells><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Human><Hypercholesteremia><Immune><Immunes><Immunodeficient Mouse><In Vitro><Injections><Investigators><Job Location><Job Place><Job Setting><Job Site><LDL Cholesterol><LDL Cholesterol Lipoproteins><LDL Receptors><LDLR gene><Lipid Transfer Protein I><Lipoprotein LDL Receptors><Liver><Low Density Lipoprotein Cholesterol><Low Density Lipoprotein Receptor><Macrophage-Derived TNF><Mature B-Cell><Mature B-Lymphocyte><Measurement><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Mentors><Methods><Mice><Mice Mammals><Modality><Modern Man><Monocyte-Derived TNF><Murine><Mus><Mutation><Patient Compliance><Patients><Plasma Cholesteryl Ester Transfer Protein><Procedures><Progenitor Cell Engraftment><Progenitor Cell Transplantation><Proprotein Convertases><Proteins><Public Health><Recombinant adeno-associated virus><Recombinant adeno-associated virus (rAAV)><Regenerative Medicine><Research Personnel><Researchers><Safety><Serotyping><Sickle Cell Anemia><Site><Stem Cell Transplantation><Stem cell transplant><Subcellular Process><Subtilisins><System><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Task Forces><Technology><Testing><Therapeutic><Therapeutic Effect><Therapeutic antibodies><Training and Infrastructure><Transgenes><Translating><Transplantation><Treatment Efficacy><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Universities><Work><Work Location><Work Place><Work-Site><Workplace><Worksite><adeno associated virus group><advisory team><antibody based therapies><antibody engineering><antibody treatment><antibody-based therapeutics><antibody-based treatment><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><autoimmune antibody><autoimmune condition><autoimmune disorder><autoimmunity disease><autoreactive antibody><beta-Lipoprotein Cholesterol><biologics><biopharmaceutical><biotherapeutic agent><blood cell progenitor><blood progenitor><blood stem cell><blood stem cell transplantation><blood-forming stem cell><cardiovascular disorder><cell engineering><cellular engineering><cellular transplant><cholesterol control><cholesterol management><developmental><disease model><disorder model><effective therapy><effective treatment><efficacy study><gene expression pattern><gene expression signature><genome editing><genome mutation><genomic editing><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><hepatic body system><hepatic organ system><high blood cholesterol><hypercholesterolemia><in vivo><in vivo engraftment><intervention efficacy><manage cholesterol><medical college><medical schools><monogenic disease><monogenic disorder><mouse model><murine model><native protein drug><nuclease><patient adherence><patient cooperation><pharmaceutical protein><progenitor biology><progenitor cell biology><progenitor transplantation><promoter><promotor><protein drug agent><protein-based drug><rAAV><receptor expression><recombinant AAV><reconstitute><reconstitution><school of medicine><self reactive antibody><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><single-gene disease><single-gene disorder><standard care><standard treatment><stem and progenitor biology><stem and progenitor cell transplantations><stem cell biology><stem cell engraftment><therapeutic efficacy><therapeutic evaluation><therapeutic protein><therapeutic testing><therapy efficacy><transcriptional profile><transcriptional signature><transcriptomics><transgene><transplant><vector><work setting>
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Yingbin Fu

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Exploratory lead · 38/100
Very recent
Active award
Team-scale grant
$1
FY 2026

Project Title

A two-pronged approach to generating novel models of photoreceptor degeneration for regenerative cell therapy

Grant Number:

5U24EY033272-05

Activity Code:

U24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2021

End Date:

7/31/2026

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Inherited retinal diseases (IRD), such as retinitis pigmentosa (RP), Leber congenital amaurosis (LCA), are a common cause of visual impairment worldwide. Recent studies show that cell replacement therapy is a promising therapeutic option for IRD patients with severe retinal degenera...

Research Terms

<Ablation><Acute><Address><Alleles><Allelomorphs><Biologic Models><Biological Models><Cell Therapy><Clinic><Diminished Vision><Disease><Disease Progression><Disorder><Electroretinography><Evaluation><Eye><Eyeball><Gene Alteration><Gene Modified><Gene Mutation><GeneHomolog><Generations><Genes><Genetic Models><Goals><Hereditary><Histologic><Histologically><Homolog><Homologous Gene><Homologue><Human><Inherited><Laser Electromagnetic><Laser Radiation><Laser injury><Lasers><Leber congenital amaurosis><Leber's amaurosis><Leber's congenital amaurosis><Low Vision><Model System><Modeling><Modern Man><Monitor><Natural regeneration><Nature><Optics><Organism><Partial Sight><Pathologic><Patients><Phenotype><Photoreceptor Cell><Photoreceptors><Photosensitive Cell><Pigmentary Retinopathy><Platinum><Platinum Black><Pt element><Reduced Vision><Regeneration><Reporting><Retina><Retinal Degeneration><Retinal Diseases><Retinal Disorder><Retinitis Pigmentosa><Rod><Rods and Cones><Specificity><Subnormal Vision><TAL effector nuclease><TAL endonuclease><TALE nuclease><TALEN technology><TALENs><Tapetoretinal Degeneration><Technology><Testing><Therapeutic><Time><Translations><Transplantation><Vertebrate Photoreceptors><Visual Receptor><Visual System><Visual impairment><amaurosis congenita of Leber><autosome><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cell based intervention><cell mediated intervention><cell mediated therapies><cell preparation><cell replacement therapy><cell replacement treatment><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><congenital amaurosis of retinal origin><degenerative retina diseases><early onset><electroretinogram><functional restoration><fundus imaging><gene defect><gene modification><genetically modified><genome editing><genomic editing><hESC><hiPSC><human ES cell><human ESC><human embryonic stem cell><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><imaging in vivo><in vivo imaging><induced human pluripotent stem cells><living system><mutant allele><novel><optical><photoreceptor degeneration><regenerate><regenerative cell><restore function><restore functionality><restore lost function><retina degeneration><retina disease><retina disorder><retinal degenerative><retinal degenerative diseases><retinal progenitor><retinal progenitor cell><retinal stem cell><retinopathy><rod and cone dystrophy><rod-cone dystrophy><tomography><transcription activator-like effector nucleases><translation><transplant><vision impairment><visually impaired>
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Johannes Zakrzewski

HACKENSACK UNIVERSITY MEDICAL CENTER, HACKENSACK, NJ

Exploratory lead · 34/100
Above-average budget
Active award
$539,448
FY 2026

Project Title

Harnessing the thymus for long-term tumor control with hematopoietic stem cell-derived naive CAR T cells

Grant Number:

5R37CA250661-05

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Chimeric receptor antigen (CAR) T cells are transforming cancer treatment by providing tumor-specific, molecularly targeted therapies. However, even though current clinical applications of CAR T cell-based cancer immunotherapies such as Kymriah or Yescarta induce remission in most ca...

Research Terms

<Address><Adoptive Cell Transfers><Affect><Affinity><Allogenic><Anti-Cancer Agents><Antigen Receptors><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Area><Assay><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Bioassay><Biologic Models><Biological><Biological Assay><Biological Models><Biology><Bioreactors><Blood Precursor Cell><Bone Marrow><Bone Marrow Reticuloendothelial System><Bypass><CAR T cell therapy><CAR T cells><CAR T therapy><CAR modified T cells><CAR-T><CAR-Ts><CD19><CD19 gene><CD28><CD28 gene><Cancer Drug><Cancer Patient><Cancer Treatment><Cancers><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Lineage><Cell Locomotion><Cell Migration><Cell Movement><Cell Signaling><Cells><Cellular Migration><Cellular Motility><Childhood><Childhood ALL><Childhood Acute Lymphoblastic Leukemia><Childhood Acute Lymphocytic Leukemia><Childhood Acute Lymphogenous Leukemia><Childhood Acute Lymphoid Leukemia><Childhood Cancers><Clinical><Consolidation Therapy><Data><Development><Disease remission><Engraftment><Epithelium><Gene Expression><Gene Transfer><Generations><Goals><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Homing><Human><Human Activities><Immune Surveillance><Immunity><Immunologic Surveillance><Immunosurveillance><Immunotherapeutic agent><In Vitro><Injections><Intracellular Communication and Signaling><L1 Lymphocytic Leukemia><Laboratories><Lymphoblastic Leukemia, Acute, L1><Maintenance><Malignant><Malignant - descriptor><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant Tumor><Malignant Tumor of the Thymus><Malignant childhood cancer><Malignant neoplasm of thymus><Mediating><Methods><Mice><Mice Mammals><Modality><Model System><Modeling><Modern Man><Modern Medicine><Molecular><Murine><Mus><Neoplastic Disease Chemotherapeutic Agents><Outcome><PDX model><Pathway interactions><Patient derived xenograft><Patients><Pediatric ALL><Pediatric Acute Lymphoblastic Leukemia><Pediatric Acute Lymphocytic Leukemia><Pediatric Acute Lymphogenous Leukemia><Pediatric Acute Lymphoid Leukemia><Peripheral><Phenotype><Pre-B ALL><Pre-B Acute Lymphoblastic Leukemia><Procedures><Production><Protocol><Protocols documentation><Publishing><Receptor Protein><Relapse><Remission><Remission Induction><Research><Risk Reduction><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><System><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell differentiation><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell reconstitution><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cells for CAR><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cell Development><T-Cell Ontogeny><T-Cell Transformation><T-Cells><T-Lymphocyte><T-Lymphocyte Development><T-cell therapeutics><T-cell transfer therapy><T44><Technology><Testing><Thymic Cancer><Thymus><Thymus Cancer><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Time><Transfusion><Tumor Antigens><Tumor Burden><Tumor Cell><Tumor Load><Tumor-Associated Antigen><Tumor-Specific Treatment Agents><Variant><Variation><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><adoptive cell therapy><adoptive cellular therapy><adult youth><anti-cancer drug><anti-cancer immunotherapy><anti-cancer therapy><anticancer immunotherapy><antigen-specific T cells><biologic><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cancer antigens><cancer immunotherapy><cancer in a child><cancer in children><cancer therapy><cancer-directed therapy><cell engineering><cell motility><cell transduction><cellular engineering><cellular transduction><chemotherapy><child with cancer><childhood malignancy><chimeric antigen T cell receptor><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cell therapy><chimeric antigen receptor T cells><chimeric antigen receptor T therapy><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><clinical applicability><clinical application><clinical relevance><clinically relevant><conditioning><cytokine release syndrome><cytokine storm><design><designing><developmental><disease control><disorder control><engineered progenitor cells><engineered stem cells><exhaustion><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><hematopoietic engraftment><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><high risk><humanized mice><humanized mouse><image guidance><image guided><immune drugs><immune-based cancer therapies><immune-based therapeutics><immunologic therapeutics><immunotherapeutics><immunotherapy agent><immunotherapy for cancer><immunotherapy of cancer><improved><in vivo><infant ALL><innovate><innovation><innovative><intravenous administration><irradiation><leukemia/lymphoma><lymphoma/leukemia><malignancy><manufacture><microbioreactor><minimally invasive><molecular targeted therapeutics><molecular targeted therapies><molecular targeted treatment><mouse model><multipotency><multipotent><murine model><neoplasm/cancer><neoplastic cell><novel><overexpress><overexpression><pathway><patient derived xenograft model><patient population><pediatric><pediatric cancer><pediatric malignancy><pre-clinical assessment><pre-clinical efficacy><preclinical assessment><preclinical efficacy><preservation><prevent relapse><progenitor cell maintenance><progenitor maintenance><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><rational design><receptor><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><relapse prevention><relapse risk><risk-reducing><scRNA sequencing><scRNA-seq><secondary lymph organ><secondary lymphatic organ><secondary lymphoid organ><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><stem cell maintenance><therapeutic T-cell platform><thymus derived lymphocyte><transduced cells><transgene expression><translational immunology><translational study><tumor><tumor specificity><tumor-specific antigen><young adult><young adult age><young adulthood>
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Julie Zhou

CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH

Exploratory lead · 34/100
Training-friendly
Active award
$82,348
FY 2026

Project Title

Internalization of dead cells governs intestinal stem cell activity

Grant Number:

5F32DK136180-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Appropriate response to injury is critical for epithelial barrier function and organismal health. In order to restore tissue homeostasis after injury, stem cells must receive signals from their surrounding niche to adjust their proliferation and differentiation at defined stages of repair. ...

Research Terms

<Address><Apoptotic><Applications Grants><Automobile Driving><Autoregulation><Biological><Biology><Body Tissues><Bone-Derived Transforming Growth Factor><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Death><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cells><Columnar Cell><Cues><Cultured Cells><Data><Disease><Disorder><Environment><Epithelial Cells><Epithelium><Future><GI Stem cell><Generalized Growth><Genetic Models><Grant Proposals><Growth><HG38><Health><Homeostasis><Host Defense><Human><In Vitro><Infection><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Ingestion><Injury><Intestinal><Intestines><Intracellular Communication and Signaling><Knowledge><LGR5><LGR5 gene><Laboratories><Lysosomes><Macrophage><Mediating><Mice><Mice Mammals><Microscopy><Milk Growth Factor><Modality><Modeling><Modern Man><Modernization><Murine><Mus><Mφ><Opsonin><Organ><Phagocytosis><Physiologic pulse><Physiological Homeostasis><Platelet Transforming Growth Factor><Polymers><Population><Process><Production><Progenitor Cells><Proliferating><Pulse><Research><Sampling><Secretory Cell><Seminal><Signal Transduction><Signal Transduction Systems><Signaling><Site><Structure of intestinal gland><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Techniques><Testing><Tissue Growth><Tissues><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Upregulation><Work><base><bases><biobank><biologic><biological signal transduction><biorepository><bowel><cell culture><cell cultures><cell type><cellular differentiation><crypts of Lieberkuhn><driving><epithelial injury><gastrointestinal stem cell><gut progenitor><gut stem cell><improved><in vivo><in vivo Model><inflammatory disease of the intestine><inflammatory disorder of the intestine><ingest><injuries><injury and repair><injury response><injury to the intestines><intestinal autoinflammation><intestinal barrier><intestinal epithelium><intestinal injury><intestinal mucosal barrier><intestinal progenitor><intestinal stem cells><mouse genetics><mouse model><murine model><necrocytosis><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><ontogeny><pharmacologic><polymer><polymeric><preservation><progenitor Cell growth><progenitor biology><progenitor cell biology><progenitor cell function><progenitor cell pool><progenitor cell population><progenitor cell proliferation><progenitor function><progenitor growth><progenitor pool><progenitor population><progenitor proliferation><programs><regenerative><regenerative growth><repair><repaired><response><response to injury><restoration><spheroids><stem><stem and progenitor biology><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor cell proliferation><stem and progenitor function><stem cell biology><stem cell function><stem cell growth><stem cell pool><stem cell population><stem cell proliferation><stem cells><therapeutic target><tool><uptake>
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Kelli Johnson

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 34/100
Training-friendly
Active award
$81,580
FY 2026

Project Title

Interrogating sub-epithelial cell heterogeneity in the developing human intestinal stem cell niche

Grant Number:

5F32DK138694-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Abstract Maintenance and regeneration of various organs is dependent upon specialized stem cell populations. These populations require highly specific environments and external cues to maintain their multipotent capabilities or specifically trigger expansion and differentiation resulting in ...

Research Terms

<1-Phosphatidylinositol 3-Kinase><Architecture><BMAC><BMP3><BMP3 gene><BRAK><Behavior><Biochemical><Body Tissues><Bolekine><Bone Morphogenetic Protein 3 Gene><CD140A><CD142><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CXC-R4><CXCL14><CXCL14 gene><CXCR-4><CXCR4><CXCR4 gene><Cancers><Capsules><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chromosome Mapping><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Coagulation Factor III Gene><Cues><Culture Media><D2S201E><Data><Data Set><Developing fetus><Development><EGF><EGF gene><Engineering / Architecture><Environment><Epithelium><Extracellular Signal-Regulated Kinase Gene><F3 gene><FB22><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fetal Development><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><GI Stem cell><Gene Expression><Gene Localization><Gene Mapping><Gene Mapping Genetics><Genes><Goals><Growth and Development><Growth and Development function><HGF Receptor><HGF gene><HGF/SF><HGFR><HM89><HSY3RR><Hepatocyte Growth Factor><Hepatocyte Growth Factor Receptor><Hepatopoietin A><Heterogeneity><Human><IBP3><IGFBP3><IGFBP3 gene><Image><Immunoblotting><In Vitro><Intestinal><Intestines><Intracellular Communication and Signaling><KS1><Kidney><Kidney Urinary System><Knock-out><Knockout><LAP3><LCR1><LESTR><Ligands><Linkage Mapping><Lung Fibroblast-Derived Mitogen><MAP Kinase Gene><MAPK><MET Protooncogene><MET gene><MGC10687><MIP-2g><MMP11><MMP11 gene><Maintenance><Malignant Neoplasms><Malignant Tumor><Matrix Metalloproteinase 11><Mediating><Mesenchymal><Mesenchymas><Mesenchyme><Methods><Mice><Mice Mammals><Mitogen-Activated Protein Kinase Gene><Modeling><Modern Man><Murine><Mus><NJAC><NPY3R><NPYR><NPYRL><NPYY3R><Natural regeneration><Organ><Organ healing><Organoids><PDGFR2><PDGFRA><PDGFRA gene><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><PTK Receptors><Pathway interactions><Pattern><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Phosphorylation><Play><Population><Progenitor Cells><Protein Phosphorylation><Protein Secretion><PtdIns 3-Kinase><Publishing><Receptor Protein><Receptor Protein-Tyrosine Kinases><Receptor Tyrosine Kinase Gene><Regeneration><Role><SCYB14><SCmRNAseq><SL-3><ST-3 Protein><ST3><ST3 Matrix Metalloproteinase><STMY3><Scatter Factor><Secretory Cell><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Single cell mRNA seq><Source><Staining method><Stains><Subcellular Process><Testing><Thromboplastin Gene><Time><Tissues><Total Human and Non-Human Gene Mapping><Transmembrane Receptor Protein Tyrosine Kinase><Transplantation><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><Tyrosine Kinase Linked Receptors><Tyrosine Kinase Receptors><Villus><Western Blotting><Western Immunoblotting><Wound Repair><base><bases><biological signal transduction><bowel><capsule><cell culture><cell cultures><cell type><cohort><design><designing><developmental><differential expression><differentially expressed><experiment><experimental research><experimental study><experiments><fetal><gastrointestinal stem cell><genetic mapping><growth media><gut progenitor><gut stem cell><human tissue><iPS><iPSC><iPSCs><imaging><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><insight><intestinal epithelium><intestinal progenitor><intestinal stem cells><loss of function><malignancy><media consumption><media use><mmp-11><multipotency><multipotent><neoplasm/cancer><novel><organ repair><organoid transplantation><pathway><pharmacologic><progenitor Cell growth><progenitor cell maintenance><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor growth><progenitor maintenance><progenitor niche><progenitor pool><progenitor population><protein blotting><receptor><regenerate><renal><scRNA sequencing><scRNA-seq><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell mRNA sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell niche><stem and progenitor cell population><stem cell growth><stem cell maintenance><stem cell niche><stem cell pool><stem cell population><stem cells><stromelysin 3><transcriptional differences><transplant><wound healing><wound recovery><wound resolution>
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Paul Alexander Kai Bump

HARVARD UNIVERSITY, CAMBRIDGE, MA

Exploratory lead · 34/100
Training-friendly
Active award
$79,348
FY 2026

Project Title

The developmental origin of adult pluripotent stem cells

Grant Number:

5F32GM153139-02

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary: Although many highly regenerative animals harbor adult pluripotent stem cells, the molecular and cellular mechanisms by which these cells form during development remains unknown in any species. Major gaps in our understanding of adult pluripotent stem cell formation include the iden...

Research Terms

<21+ years old><ATAC sequencing><ATAC-seq><ATACseq><Address><Adult><Adult Human><Affect><Animals><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Award><Basal Transcription Factor><Basal transcription factor genes><Behavior><Binding Sites><Bioassay><Biologic Models><Biological><Biological Assay><Biological Models><Body Tissues><CUT&RUN><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Lineage><Cells><Chromatin><Cleavage Targets and Release Using Nuclease><Cleavage Under Targets and Release Using Nuclease><Combining Site><Control Animal><Data><Development><Developmental Biology><Discipline><Disease><Disorder><ES cell><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Fellowship><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Transcription><Genomics><Goals><Health><Human><Invertebrata><Invertebrates><Knowledge><Label><Learning><Left><Link><Maintenance><Mammalia><Mammals><Methods><Methylation><Mission><Model System><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><NIH><National Institutes of Health><Natural regeneration><Nature><Organism><Outcome><Pattern><Phenotype><Pluripotent Stem Cells><Population><Post-Transcriptional Gene Silencing><Process><Progenitor Cells><Property><Proteins><RNA Expression><RNA Interference><RNA Silencing><RNAi><Reactive Site><Regeneration><Regenerative research><Regulation><Repression><Research><Sequence-Specific Posttranscriptional Gene Silencing><Sorting><Specific qualifier value><Specified><System><Testing><Tissues><Training><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transgenic Organisms><United States National Institutes of Health><Universities><Vertebrate Animals><Vertebrates><Work><adult animal><adulthood><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><biologic><cell type><cellular differentiation><developmental><differential expression><differentially expressed><early embryonic stage><embryo cell><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><epigenetically><epigenomics><experience><gene locus><gene regulatory network><genetic element><genetic locus><genomic location><genomic locus><histone methylation><innovate><innovation><innovative><insight><knock-down><knockdown><living system><mature animal><molecular profile><molecular signature><novel><pluripotency><pluripotent progenitor><pluripotent state><progenitor biology><progenitor cell biology><progenitor cell gene><progenitor cell pool><progenitor cell population><progenitor gene><progenitor pool><progenitor population><regenerate><regeneration research><regeneration studies><regenerative><regenerative studies><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><stem><stem and progenitor biology><stem and progenitor cell population><stem cell biology><stem cell genes><stem cell of embryonic origin><stem cell pool><stem cell population><stem cells><tool><training opportunity><transcription factor><transcriptional differences><transgenic><vertebrata>
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Michaela Katherine Quintero

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 34/100
Training-friendly
Active award
$79,348
FY 2026

Project Title

Defining the Notch niche for Intestinal Stem cells

Grant Number:

5F32DK142253-02

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY This proposal seeks to train a postdoctoral fellow in the experimental technologies and conceptual knowledge required to become a successful academic researcher in gastrointestinal stem cell biology. The research proposal aims to elucidate the mechanisms of Notch signaling in immatur...

Research Terms

<21+ years old><Ablation><Acute><Address><Adult><Adult Human><Apoptosis><Apoptosis Pathway><Architecture><Autoregulation><Bioinformatics><CUT&RUN><Cell Body><Cell Communication and Signaling><Cell Growth and Maintenance><Cell Isolation><Cell Lineage><Cell Maintenance><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Signaling><Cell Survival><Cell Viability><Cells><Cleavage Targets and Release Using Nuclease><Cleavage Under Targets and Release Using Nuclease><Corynebacterium Diphtheriae Toxin><Development><Diphtheria Toxin><Disease><Disorder><Drug Screening><Engineering / Architecture><Epithelial Cells><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><GI Stem cell><Gastrointestinal Diseases><Gastrointestinal Physiology><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Models><Gestation><Goals><Homeostasis><In Situ Hybridization><In Vitro><Injury><Intestinal><Intestines><Intracellular Communication and Signaling><Investigators><Knowledge><Laboratories><Libraries><Ligands><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Organoids><Paneth Cells><Pathway interactions><Physiological Homeostasis><Postdoc><Postdoctoral Fellow><Pregnancy><Process><Progenitor Cells><Programmed Cell Death><RNA Seq><RNA sequencing><RNAseq><Recombinant DNA Technology><Regenerative Medicine><Regulation><Reporter><Reporting><Research Associate><Research Personnel><Research Proposals><Researchers><Science><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Sorting><Source><Stem Cell like><Surface><System><Techniques><Technology><Testing><Training><Transmission Electron Microscopy><adulthood><biological signal transduction><bowel><career><cell imaging><cell sorting><cellular imaging><design><designing><developmental><flow cytophotometry><gastrointestinal disorder><gastrointestinal stem cell><genetically engineered><global gene expression><global transcription profile><gut progenitor><gut stem cell><in situ Hybridization Genetics><in situ Hybridization Staining Method><in vivo><injuries><injury to the intestines><intestinal barrier><intestinal injury><intestinal mucosal barrier><intestinal progenitor><intestinal stem cells><mouse genetics><mouse model><murine model><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><notch><notch protein><notch receptors><novel><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathway><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><postnatal><progenitor biology><progenitor capacity><progenitor cell biology><progenitor cell function><progenitor cell like><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor cell regeneration><progenitor cell self renewal><progenitor function><progenitor niche><progenitor pool><progenitor population><progenitor regeneration><progenitor self renewal><progenitor-like><repair><repaired><research associates><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><stem and progenitor biology><stem and progenitor cell function><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor function><stem cell biology><stem cell characteristics><stem cell function><stem cell niche><stem cell pool><stem cell population><stem cell regeneration><stem cell self renewal><stem cells><stem-like><stemness><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics>
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Sarah Leichter

FRED HUTCHINSON CANCER CENTER, SEATTLE, WA

Exploratory lead · 34/100
Training-friendly
Active award
$79,348
FY 2026

Project Title

Investigating the chromatin landscape of complex tissues through cell-type-specific patterns

Grant Number:

5F32GM153148-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract The long-term objectives of this proposal include the following: 1) to generate cell-type- specific chromatin profiles of the four cell types of the intestine, 2) to identify the effect crippled silencing in intestinal stem cells has on progenitor cells, and 3) to character...

Research Terms

<Affect><Age><Aging><Autoregulation><Biologic Models><Biological Function><Biological Models><Biological Process><Biology><Body Tissues><Cell Body><Cell Count><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Isolation><Cell Number><Cell Physiology><Cell Process><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular injury><Chromatin><Complex><Critical Paths><Critical Pathways><Cytology><DNA-Dependent RNA Polymerase II><Development><Digestion><Disease><Disorder><Drosophila><Drosophila genus><Drosophila melanogaster><Enteroendocrine Cell><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Expression Signature><Flies><Fluorescence Activated Cell Sorting Fractionation><Fluorescence-Activated Cell Sorting><Fluorescence-Activated Cell Sortings><Funding><GI Stem cell><Gene Action Regulation><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profile><Gene Expression Profiling><Gene Expression Regulation><Gene Inactivation><Gene Regulation><Gene Regulation Process><Gene Silencing><Gene Transcription><Genetic Markers><Genetic Transcription><Genome><Histone H3><Histones><Homeostasis><Individual><Intestinal><Intestines><Investigation><L-Lysine><Lysine><Maps><Mediating><Methylation><Microbe><Mission><Mitotic><Model System><Modification><NIGMS><National Institute of General Medical Sciences><Organism><Pathway interactions><Pattern><Phenotype><Physiological Homeostasis><Play><Polycomb><Population><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Process><Progenitor Cells><Proliferating><Protein Modification><RNA Expression><RNA Polymerase B><RNA Polymerase II><Research><Role><Source><Stimulus><Subcellular Process><System><Tail><Techniques><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><age associated><age associated effects><age correlated><age dependent><age effect><age linked><age related><age related effects><age specific><ages><aging effect><analyze gene expression><bowel><cell damage><cell injury><cell sorting><cell type><cellular damage><cellular differentiation><chromatin modification><damage to cells><developmental><epigenetically><fly><fruit fly><gastrointestinal stem cell><gene biomarker><gene expression analysis><gene expression assay><gene expression biomarker><gene expression pattern><gene expression signature><gene manipulation><gene marker><gene signature biomarker><genetic biomarker><genetic manipulation><genetically manipulate><genetically perturb><genome scale><genome-wide><genomewide><gut progenitor><gut stem cell><histone modification><hormonal signals><hormone signals><impact of age><influence of age><injury to cells><insight><interest><intestinal progenitor><intestinal stem cells><knock-down><knockdown><life span><lifespan><living system><mammalian genome><nutrient absorption><pathway><prevent><preventing><progenitor><progenitor cell maintenance><progenitor cell pool><progenitor cell population><progenitor maintenance><progenitor pool><progenitor population><social role><stem><stem and progenitor cell population><stem cell maintenance><stem cell pool><stem cell population><stem cells><transcriptional profile><transcriptional profiling><transcriptional signature><transcriptional silencing><uH2A>
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Javier Contreras

RESEARCH INST NATIONWIDE CHILDREN'S HOSP, COLUMBUS, OH

Exploratory lead · 34/100
Training-friendly
Active award
$43,714
FY 2026

Project Title

A HUMAN IPSC-BASED ORGANOID PLATFORM FOR STUDYING MATERNAL HYPERGLYCEMIA-INDUCED CONGENITAL HEART DEFECTS

Grant Number:

5F31HD113330-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Congenital heart defects (CHD) are the most common type of birth defect, with cardiac malformation resulting from abnormal heat development contributed by genetic and/or environmental risk factors. The association of maternal diabetes with increased offspring CHD incidence is proposed to be attribut...

Research Terms

<2-dimensional><21+ years old><3-D><3-Dimensional><3D><Active Oxygen><Address><Adherent Culture><Adult><Adult Human><Affect><Animals><Apoptosis><Apoptosis Pathway><Assay><Bioassay><Biological><Biological Assay><Birth Defects><Blood Glucose><Blood Sugar><Cardiac><Cardiac Malformation><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac defect><Cardiac development><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Differentiation><Cell Differentiation process><Cell Lineage><Cell Maturation><Cell Signaling><Cells><Cellular Metabolic Process><Cellular injury><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Cardiac Defects><Congenital Defects><Congenital Deformity><Congenital Heart Defects><Congenital Malformation><Culture Media><D-Glucose><Development><Dextrose><Diabetic mother><Differentiated Gene><Disease><Disorder><Dose><Embryo Development><Embryogenesis><Embryonic Development><Endothelium><Environment><Environmental Factor><Environmental Risk Factor><Fluorescence><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generations><Genes><Genetic Risk><Gestation><Gestational Diabetes><Gestational Diabetes Mellitus><Glucose><Goals><Heart><Heart Malformation><Heart Muscle Cells><Heart Vascular><Heart myocyte><Heterogeneity><Human><Hyperglycemia><Immunofluorescence><Immunofluorescence Immunologic><Impairment><Incidence><Infant Mortality><Infant Mortality Total><Intermediary Metabolism><Intracellular Communication and Signaling><Knowledge><Live Birth><Measures><Mesoderm><Mesoderm Cell><Mesodermal Cell><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Monolayer culture><Murine><Mus><Myocardial><Organ><Organoids><Oxidative Stress><Oxygen Radicals><Pathogenesis><Phenotype><Physiologic><Physiological><Physiology><Population><Pregnancy><Pregnancy-Induced Diabetes><Pregnant Women><Pro-Oxidants><Production><Progenitor Cells><Programmed Cell Death><RNA Seq><RNA sequencing><RNAseq><Reactive Oxygen Species><Reporting><Respiration><Risk><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Specific qualifier value><Specified><Staining method><Stains><Stem Cell Development><Stem cell in the heart><Structure><Supplementation><Transcript Expression Analyses><Transcript Expression Analysis><Translations><WNT Signaling Pathway><WNT signaling><abnormal heart development><adulthood><analyze gene expression><biologic><biological signal transduction><cardiac progenitor><cardiac stem cell><cardiogenesis><cardiomyocyte><cell culture><cell cultures><cell damage><cell determination><cell injury><cell metabolism><cell type><cellular damage><cellular differentiation><cellular metabaolism><circulatory system><congenital cardiac abnormality><congenital cardiac anomalies><congenital cardiac disease><congenital cardiac disorder><congenital cardiac malformation><congenital heart abnormality><congenital heart anomaly><congenital heart disease><congenital heart disorder><congenital heart malformation><damage to cells><death among infants><death in first year of life><death in infancy><death in infants><developmental><differential expression><differentially expressed><differentiation protocol><environmental risk><expectant mother><expectant women><expecting mother><expecting women><gene expression analysis><gene expression assay><growth media><heart cell><heart defect><heart development><heart formation><heart progenitor><heart stem cell><hiPSC><high risk><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human model><human progenitor><human stem cells><human tissue><hyperglycemic><iPS><iPSC><iPSCs><individuals who are pregnant><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infant death><infant demise><infantile death><injury to cells><insight><interest><maternal diabetes><maternal hyperglycemia><mitochondrial><mitochondrial metabolism><model of human><mortality><mortality in infants><mouse model><murine model><offspring><oxidative damage><oxidative injury><people who are pregnant><pregnancy diabetes><pregnant females><pregnant mothers><pregnant people><pregnant populations><progenitor cell development><progenitor cell differentiation><progenitor development><progenitor differentiation><respiratory mechanism><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><stem and progenitor cell development><stem and progenitor differentiation><stem cell differentiation><stem cells><therapeutic evaluation><therapeutic testing><those who are pregnant><three dimensional><transcriptional differences><transcriptional profiling><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translation><two-dimensional><women who are pregnant>
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Alana Catherine Bernys

PRINCETON UNIVERSITY, Princeton, NJ

Exploratory lead · 34/100
Training-friendly
Active award
$34,114
FY 2026

Project Title

Mechanisms of cell cycle regulation in embryos of normal and unusual size

Grant Number:

5F31HD115409-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

11/1/2024

End Date:

10/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Mammalian development is a remarkably robust process that employs self-organization and corrective processes to coordinate individual cell behaviors for proper development. One example is the embryo’s capacity for cell number regulation. In mouse embryos in which cell number is exper...

Research Terms

<Acceleration><Apical><Apoptosis><Apoptosis Pathway><Assay><Basement membrane><Bioassay><Biological Assay><Blastocyst Implantation><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Count><Cell Cycle><Cell Cycle Control><Cell Cycle Progression><Cell Cycle Regulation><Cell Division Cycle><Cell Number><Cell Signaling><Cells><Collagen><Communication><Conceptus><Data Analyses><Data Analysis><Defect><Development><Developmental Biology><ES cell><Educational workshop><Embryo><Embryo Development><Embryo Implantation><Embryogenesis><Embryology><Embryonic><Embryonic Development><Ensure><Environment><Epiblast><Epithelium><Exhibits><Exposure to><G1/S Transition><G2/M Transition><Generalized Growth><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Goals><Growth><Image><Impairment><Implant><Individual><Integrins><Integrins Extracellular Matrix><Intracellular Communication and Signaling><Investigation><Investigators><Link><Maintenance><Mammalia><Mammals><Manuscripts><Measurement><Membrane><Methods><Mice><Mice Mammals><Molecular Probes><Morphogenesis><Murine><Mus><Nidation><Nuclear><Ovum Implantation><Phase><Process><Programmed Cell Death><Proliferating><Recombinant DNA Technology><Regulation><Reporter><Research Personnel><Researchers><Resistance><Role><Sampling><Science><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Site><Surface><System><Testing><Time><Tissue Growth><Tissues><Training><Universities><Uterus><Work><Workshop><Writing><biological signal transduction><cell behavior><cellular behavior><data interpretation><design><designing><developmental><embryo attachment><embryo cell><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><ex vivo imaging><genetically engineered><imaging><implantation><insight><membrane structure><migration><morphogenetic process><natural Blastocyst Implantation><novel><ontogeny><outreach><preimplantation><prevent><preventing><progenitor cell model><progenitor model><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><resistant><self organization><skills><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stem cell of embryonic origin><success><womb>
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Tuomas Tammela

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Exploratory lead · 32/100
Solid budget
Recent
Active award
$490,849
FY 2026

Project Title

Targeting stem-like cells and their niche in pancreatic cancer

Grant Number:

5R37CA244911-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY Less than 8% of pancreatic ductal adenocarcinoma (PDAC) patients are alive 5 years after diagnosis. PDAC is typically diagnosed at an advanced stage, limiting treatment options. Chemotherapies are the mainstay for advanced PDAC, though they produce incomplete responses. Thus, develop...

Research Terms

<21+ years old><Ablation><Acyltransferase><Adult><Adult Human><Alleles><Allelomorphs><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Basal Cell><Biology><C-K-RAS><Cancer Drug><Cancer Treatment><Cell Body><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Signaling><Cells><Characteristics><Colorectal Adenocarcinoma><Complex><Cycloamylose><Cyclodextrins><Cyclomaltooligosaccharides><DNA mutation><Data><Desmoplastic><Desmoplastic Reaction><Development><Diagnosis><Drug Delivery><Drug Delivery Systems><EC 2.3><Enzyme Gene><Enzymes><Failure><GEM model><GEMM model><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetically Engineered Mouse><Growth Agents><Growth Factor><Growth Substances><HG38><HSP-90><HSP90><Heat-Shock Proteins 90><Heterogeneity><Human><Immune><Immunes><In Vitro><Intracellular Communication and Signaling><Investments><K-RAS2A><K-RAS2B><K-Ras><K-Ras 2A><K-Ras-2 Oncogene><KRAS><KRAS2><KRAS2 gene><Ki-RAS><LGR5><LGR5 gene><Large Bowel Adenocarcinoma><Large Intestine Adenocarcinoma><Ligands><Lineage Tracing><Lung Adenocarcinoma><MEKs><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Pancreatic Neoplasm><Malignant neoplasm of pancreas><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Methods><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutation><Neoplasm Metastasis><Neoplastic Disease Chemotherapeutic Agents><Normal Tissue><Normal tissue morphology><Oncogene K-Ras><PDA model><PDAC Model><PDAC cancer cell><PDAC cell><PDX model><Pancreas><Pancreas Cancer><Pancreas Ductal Adenocarcinoma><Pancreas Neoplasms><Pancreas Tumor><Pancreatic><Pancreatic Cancer><Pancreatic Ductal Adenocarcinoma><Pancreatic Tumor><Patient derived xenograft><Patients><Phenotype><Population><Porcupines><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Primary Neoplasm><Primary Tumor><Progenitor Cells><Proliferating><Property><Protein Modification><Proteins Growth Factors><Proteomics><RASK2><Reporter><Reporting><Resistance><Role><SOX11><SOX11 gene><SRY-Box 11><SRY-Related HMG-Box Gene 11><Secondary Neoplasm><Secondary Tumor><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Solid Neoplasm><Solid Tumor><Stem Cell like><Testing><Therapeutic><Toxic effect><Toxicities><Transcript Expression Analyses><Transcript Expression Analysis><Translating><Tumor-Specific Treatment Agents><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><WNT Signaling Pathway><WNT signaling><addiction><addictive disorder><adulthood><analyze gene expression><anti-cancer drug><anti-cancer therapy><biological signal transduction><cancer cell><cancer metastasis><cancer progenitor><cancer progenitor cells><cancer progression><cancer stem cell><cancer stem like cell><cancer therapy><cancer-directed therapy><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><chemotherapy><conventional therapy><conventional treatment><developmental><gene expression analysis><gene expression assay><genetically engineered mouse model><genetically engineered murine model><genome mutation><hsp90 Family><improved><in vivo><inhibitor><inhibitor drug><inhibitor therapeutic><inhibitor therapy><insight><malignant progenitor><malignant stem cell><mutant><neoplasm progression><neoplastic progression><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><oncogenic progenitor><oncogenic stem cells><palmitoylation><pancreatic cancer cells><pancreatic ductal adenocarcinoma cell><pancreatic ductal adenocarcinoma model><pancreatic malignancy><pancreatic neoplasia><pancreatic neoplasm><pancreatic tumor cells><patient derived xenograft model><progenitor capacity><progenitor cell like><progenitor like cancer cell><progenitor-like><progenitor-like cell><proliferation capability><proliferation capacity><proliferation potential><proliferative capability><proliferative capacity><proliferative potential><resistance to therapy><resistant><resistant to therapy><response><small molecular inhibitor><small molecule><small molecule inhibitor><social role><stem cell characteristics><stem cells><stem like cancer cell><stem-like><stem-like cell><stemness><subcutaneous><subdermal><therapeutic evaluation><therapeutic resistance><therapeutic target><therapeutic testing><therapy resistant><transcriptional profiling><treatment resistance><tumor><tumor cell metastasis><tumor progression><ubiquitin ligase><v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog>
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Oren Levy

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 32/100
Solid budget
Recent
Active award
$479,610
FY 2026

Project Title

AI-guided Intestinal stem cell activation for mucosal restoration in ulcerative colitis

Grant Number:

1R21AI196527-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/18/2026

End Date:

1/31/2028

Project Abstract

ABSTRACT The mucus layer of the digestive system plays a key role in innate immunity, protecting intestinal epithelium from commensal bacteria, pathogens, and toxins. Goblet cells (GCs), secretory cells residing in the intestinal epithelium, are essential for mucin secretion to form this protective ...

Research Terms

<5-Aminosalicylic Acid><AI based><AI based platform><AI platform><AI system><Abdominal Pain><Acute><Address><Adrenal Cortex Hormones><Adverse Experience><Adverse effects><Adverse event><Affect><Ailmentary System><Alimentary System><American><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Artificial Intelligence><Artificial Intelligence platform><Asacol><Automobile Driving><Biological><Biological Agent><Biological Products><Biopsy><Body Weight decreased><Cell Body><Cell Count><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Number><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Chemicals><Chronic><Colectomy><Colitis><Colon><Colorectal Cancer><Computer Reasoning><Corticoids><Corticosteroids><Data Bases><Data Set><Databases><Dedications><Defect><Development><Diarrhea><Differentiation in cell culture><Digestive System><Disease remission><Drug Screening><Drug Therapy><Drugs><Dysfunction><Epithelial Cells><Epithelium><Evaluation><Fever><Flare><Functional disorder><GI Stem cell><Gastrointestinal Body System><Gastrointestinal Organ System><Genetic><Goblet Cells><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Human><Immune><Immunes><Immunosuppressants><Immunosuppressive Agents><Immunosuppressive drug><Immunosuppressive treatment><Impairment><In Vitro><In vitro cell differentiation><Inducer Cells><Inducer T-Lymphocytes><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Innate Immunity><Invaded><Lead><Leanness><Libraries><MUC2><Machine Intelligence><Medication><Mesalamine><Mesalazine><Mice><Mice Mammals><Modality><Modern Man><Mucin 2><Mucin-2 Staining Method><Mucins><Mucosa><Mucosal Tissue><Mucous Membrane><Mucous body substance><Mucus><Mucus Glycoprotein><Multiomic Data><Murine><Mus><Native Immunity><Natural Immunity><Natural regeneration><Non-Specific Immunity><Nonspecific Immunity><Operative Procedures><Operative Surgical Procedures><Organoids><Pathogenesis><Pathway interactions><Patients><Pb element><Pentasa><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Physiopathology><Play><Population><Process><Progenitor Cells><Pyrexia><Rectum><Recurrence><Recurrent><Refractory><Regeneration><Rejuvenation><Relapse><Remission><Remission Induction><Risk><Role><Rowasa><Scanning><Secretory Cell><Signal Pathway><Stem Cell like><Subcellular Process><Surface><Surgical><Surgical Interventions><Surgical Procedure><Symptoms><Therapeutic><Therapeutic Effect><Thinness><Toxin><Ulcerated Colitis><Ulcerative Colitis><Weight Loss><Weight Reduction><artificial intelligence based><biologic><biologics><biopharmaceutical><biotherapeutic agent><body weight loss><cellular differentiation><chemical library><clinical relevance><clinical remission><clinically relevant><colitis mouse model><colitis murine model><colonic crypt><commensal bacteria><commensal bacterial species><data base><developmental><differentiation in culture><differentiation in vitro><driving><drug intervention><drug treatment><drug/agent><druggable target><effective therapy><effective treatment><febrile><febris><gastrointestinal stem cell><gastrointestinal system><gut progenitor><gut stem cell><heavy metal Pb><heavy metal lead><immune suppressive agent><immune suppressor><immunosuppressive substance><immunosuppressor><in vitro Model><in vitro cellular differentiation><in vivo Model><inflammatory disease of the intestine><inflammatory disorder of the intestine><intestinal autoinflammation><intestinal epithelium><intestinal progenitor><intestinal stem cells><m-Aminosalicylic Acid><manage symptom><meta-Aminosalicylic Acid><microbial><mouse colitis><mucous><multiomics><multiple omic data><multiple omics><murine colitis><novel><panomics><pathogen><pathophysiology><pathway><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><prevent><preventing><progenitor capacity><progenitor cell differentiation><progenitor cell like><progenitor cell niche><progenitor differentiation><progenitor niche><progenitor-like><regenerate><regeneration potential><regenerative potential><regenerative treatment><restoration><small molecule><small molecule libraries><social role><stem and progenitor cell niche><stem and progenitor differentiation><stem cell characteristics><stem cell differentiation><stem cell niche><stem cells><stem-like><stemness><surgery><symptom management><treatment strategy><wt-loss>
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Rose-Anne Romano

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Exploratory lead · 32/100
Solid budget
Recent
Active award
$440,275
FY 2026

Project Title

Transcriptional regulatory Mechanisms of Salivary gland Regeneration in a defined genetic model

Grant Number:

1R21DE035609-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Salivary gland (SG) regeneration involves a coordinated interplay of self-renewal, cell fate determination, and differentiation programs in stem/progenitor epithelial cells. Identifying the transcriptional and signaling networks that govern these complex processes is crucial for und...

Research Terms

<3-D><3-Dimensional><3D><Active Follow-up><Aging><Area><Autoimmune><Automobile Driving><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Binding><Biologic Models><Biological Agent><Biological Models><Biological Products><Biology><Cancers><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell-to-Cell Interaction><Cells><Chromatin><Closure by Ligation><Complex><Data Set><Development><Disease><Disorder><Duct><Duct (organ) structure><Dysfunction><Ecologic Systems><Ecological Systems><Ecosystem><Enhancers><Equilibrium><Failure><Family><Foundations><Functional disorder><Gene Down-Regulation><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Models><Genetic Transcription><Genomic approach><Genomics><Gland><Histones><Homeo Boxes><Homeobox><Homeostasis><Human><Inflammatory><Injury><Intracellular Communication and Signaling><KO mice><Kidney><Kidney Urinary System><Knock-out Mice><Knockout Mice><Knowledge><Ligation><Malignant Neoplasms><Malignant Tumor><Maps><Mice><Mice Mammals><Model System><Modeling><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Muscle><Muscle Tissue><Natural regeneration><Null Mouse><Organ><Outcome><Patients><Phenotype><Physiological Homeostasis><Physiopathology><Play><Population><Process><Progenitor Cells><Proliferating><RNA Expression><Regeneration><Regulatory Element><Research><Resolution><Role><Salivary Gland Tissue><Salivary Glands><Shapes><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Submandibular gland><Submaxillary Gland><Systems Biology><Testing><Therapeutic Intervention><Transcription><Transcription Factor Proto-Oncogene><Transcription Repression><Transcription factor genes><active followup><balance><balance function><biological signal transduction><biologics><biopharmaceutical><biotherapeutic agent><cell fate specification><cell regeneration><cell type><cellular regeneration><conditional knock-out><conditional knockout><defined contribution><developmental><driving><epigenome><epigenome profiling><epigenomic profiling><epigenomics><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><experiment><experimental research><experimental study><experiments><follow up><follow-up><followed up><followup><gene repression><genetic approach><genetic strategy><genomic effort><genomic strategy><high reward><high risk><improved><injured><injuries><innovate><innovation><innovative><insight><interest><intervention therapy><knock-out animal><knockout animal><malignancy><member><mouse model><murine model><muscular><neoplasm/cancer><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathophysiology><progenitor cell based therapy><progenitor cell differentiation><progenitor cell function><progenitor cell therapy><progenitor cell treatment><progenitor differentiation><progenitor function><progenitor therapy><progenitor treatment><programs><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regenerative><renal><resolutions><response><scATAC sequencing><scATAC-seq><scRNA sequencing><scRNA-seq><self-renew><self-renewal><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell sequencing assay for transposase accessible chromatin><single cell transcriptomic profiling><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell RNA sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><social role><spatial and temporal><spatial temporal><spatiotemporal><stem><stem and progenitor cell function><stem and progenitor cell therapy><stem and progenitor differentiation><stem and progenitor function><stem cell based therapy><stem cell differentiation><stem cell function><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><three dimensional><tissue regeneration><tissue regrowth><tissue renewal><tissue repair><tissue specific regeneration><transcription factor><transcription regulatory network><transcriptomics>
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Darcie Leann Moore

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 32/100
Solid budget
Recent
Active award
$415,717
FY 2026

Project Title

Revealing the role of vimentin in adult mouse hippocampal neurogenesis

Grant Number:

1R21NS140909-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2026

End Date:

2/28/2028

Project Abstract

Project Summary Neural stem cells (NSCs) in the brain generate newborn neurons throughout life, providing an endogenous stem cell pool that can be harnessed to improve cognitive function during aging and neurodegenerative disease. Thus, understanding how adult neurogenesis is regulated may provide ...

Research Terms

<0-4 weeks old><2-photon><20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><21+ years old><3' Untranslated Regions><3'UTR><Acute><Address><Adult><Adult Human><Affect><Age><Aging><Ammon Horn><Anesthesia><Anesthesia procedures><Antibodies><Assay><Astroprotein><Behavioral Assay><Bioassay><Biological Assay><Birth><Brain><Brain Nervous System><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Culture Techniques><Cell Death><Cell division><Cells><Centrosome><Cephalic><Cessation of life><Chaperone><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cognitive><Communities><Cornu Ammonis><Cranial><Cultured Cells><Daughter><Death><Degenerative Neurologic Disorders><Disease><Disorder><Encephalon><Fibroblast Intermediate Filament Proteins><GFA-Protein><GFAP><Gene Transcription><Genetic Transcription><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Head><Hereditary><Hippocampus><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><In Vitro><Inherited><Intermediate Filament Proteins><Investigators><Knowledge><Label><Life><Link><Macropain><Macroxyproteinase><Memory><Messenger RNA><Mice><Mice Mammals><Micro-tubule><Microtubules><Molecular Chaperones><Multicatalytic Proteinase><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural Stem Cell><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurons><Neurosphere><Newborn Infant><Newborns><Outcome><Parturition><Pattern><Perfusion><Play><Preparation><Process><Progenitor Cells><Proliferating><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteosome><RNA Expression><RNA-Binding Proteins><Radial><Radius><Regulation><Rejuvenation><Reporter><Repression><Research Personnel><Researchers><Resting progenitor><Role><Running><Sorting><Source><Structure><Therapeutic><Transcription><Transgenic Mice><Translational Inhibition><Translational Repression><Translations><Travel><Upregulation><Vimentin><Visualization><adult neurogenesis><adulthood><ages><anxiety reduction><cell behavior><cell culture><cell cultures><cell type><cellular behavior><cognitive function><cranial implant><daughter cell><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><dormant stem cell><endogenous progenitor><endogenous stem cells><experiment><experimental research><experimental study><experiments><flexibility><flexible><fluorophore><head-to-head analysis><head-to-head comparison><hippocampal><imaging><imaging in vivo><improved><in vivo><in vivo imaging><inactive stem cell><latent progenitor><latent stem cell><mRNA><multicatalytic endopeptidase complex><necrocytosis><nerve stem cell><nestin><nestin protein><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodegenerative illness><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><newborn child><newborn children><newborn neuron><novel><preparations><progenitor><progenitor and neural stem cells><progenitor biology><progenitor cell biology><progenitor cell division><progenitor cell function><progenitor cell markers><progenitor cell pool><progenitor cell population><progenitor cell renewal><progenitor division><progenitor function><progenitor markers><progenitor pool><progenitor population><progenitor renewal><progenitor stem cell markers><promoter><promotor><prospective><protein homeostasis><proteostasis><quiescent progenitor><quiescent stem cells><resting stem cell><scRNA sequencing><scRNA-seq><segregation><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skull implant><social role><stem and progenitor biology><stem and progenitor cell division><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor cell renewal><stem and progenitor function><stem cell biology><stem cell biomarkers><stem cell division><stem cell function><stem cell markers><stem cell pool><stem cell population><stem cell quiescence><stem cell renewal><stem cells><tool><translation><two-photon>
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Karuna Ganesh

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Exploratory lead · 32/100
Solid budget
Recent
Active award
$404,888
FY 2026

Project Title

Mechanisms of Dynamic Transcriptional Reprogramming in Metastasis Stem Cells

Grant Number:

5R37CA266185-05

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

1/31/2027

Project Abstract

Metastasis causes >90% of cancer death. The persistence and lethality of metastasis is driven by cells capable of self-renewal, slow cell-cycling, tumor re-initiation, and therapy resistance, termed metastasis stem cells (MetSCs). Development of effective strategies for eliminating metastasis requir...

Research Terms

<3' Untranslated Regions><3'UTR><Acceleration><Adherens Junction><Adhering Junction><Adhesive Junction><Advanced Cancer><Advanced Malignant Neoplasm><Anchoring Junction><Assay><Autoregulation><Binding><Binding Proteins><Bioassay><Biochemical><Biologic Models><Biological Assay><Biological Models><Body Tissues><CALL protein><Cadherin-1><CamL1 Gene Product><Cancer Cause><Cancer Etiology><Cancer Genes><Cancer-Promoting Gene><Cancers><Cell Body><Cell Cycle><Cell Division Cycle><Cell Surface Glycoprotein L1><Cells><Cessation of life><Chromatin><Clinical><Colitis><Colon><Colorectal Cancer><Complex><Cytoplasmic Granules><DNA mutation><Data><Death><Development><Disseminated Malignant Neoplasm><Distant><E-Cadherin><Elements><Engineering><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelial Calcium-Dependent Adhesion Protein><Epithelial Cells><Epithelial-Cadherin><Epithelium><F11 Glycoprotein><Family><Fluorescence><GI Stem cell><Gene Expression><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><HG38><Heterograft><Heterologous Transplantation><Homeostasis><Immune Precipitation><Immunofluorescence><Immunofluorescence Immunologic><Immunoprecipitation><Impairment><Injections><Intestinal><Intestinal Neoplasia><Intestinal Neoplasms><Intestinal Tumor><Intestines><Intestines Neoplasms><Invaded><Knock-in><L1 Cell Adhesion Molecule><L1CAM><LGR5><LGR5 gene><Ligand Binding Protein><Ligand Binding Protein Gene><Maintenance><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mediating><Mediator><Messenger RNA><Metastasis><Metastasize><Metastatic Cancer><Metastatic Lesion><Metastatic Malignant Neoplasm><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Model System><Modeling><Molecular><Molecular Interaction><Mutation><NGF-Inducible Glycoprotein><NILE Glycoprotein><NILE Protein><Natural regeneration><Neoplasm Metastasis><Nerve Cells><Nerve Growth Factor-Inducible Large External Glycoprotein><Nerve Unit><Neural Adhesion Molecule L1><Neural Cell><Neural Cell Adhesion Molecule L1><Neurocyte><Neuroendocrine><Neuroendocrine System><Neurons><Neurosecretory Systems><Non-Polyadenylated RNA><Oncogenes><Organ><Organoids><Outcome><Output><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phase><Phenotype><Physiologic><Physiologic pulse><Physiological><Physiological Homeostasis><Primary Neoplasm><Primary Tumor><Progenitor Cells><Proliferating><Protein Binding><Proteins><Pulse><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA sequencing><RNA-Binding Proteins><RNAseq><Rectum><Recurrence><Recurrent><Regeneration><Regulation><Reporter><Resistance><Ribonucleic Acid><Role><SCmRNAseq><Sampling><Secondary Neoplasm><Secondary Tumor><Single cell mRNA seq><Splenic Vein><Stem Cell like><Stress><Structure><Structure of splenic vein><Time><Tissues><Transcription><Transforming Genes><Tumor Suppressor Proteins><UTRs><Untranslated Regions><Uvomorulin><Work><Wound Repair><Xenograft><Xenograft procedure><Xenotransplantation><bound protein><bowel><cancer cell><cancer initiation><cancer metastasis><cancer progenitor><cancer progenitor cells><cancer progression><cancer stem cell><cancer stem like cell><colorectal cancer metastasis><crosslink><derepression><developmental><entire genome><epigenetically><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><full genome><gastrointestinal stem cell><genome mutation><granule><gut progenitor><gut stem cell><in vivo><insight><intestinal epithelium><intestinal progenitor><intestinal stem cells><knock-down><knockdown><knockin><mRNA><mRNA Degradation><mRNA Transcript Degradation><malignancy><malignant progenitor><malignant stem cell><member><mouse model><murine model><neoplasm progression><neoplasm/cancer><neoplastic><neoplastic progression><neuroendocrine differentiation><neuronal><novel><oncogenic progenitor><oncogenic stem cells><overexpress><overexpression><patient oriented outcomes><posttranscriptional><progenitor capacity><progenitor cell like><progenitor cell regeneration><progenitor cell self renewal><progenitor like cancer cell><progenitor regeneration><progenitor self renewal><progenitor-like><programs><protein complex><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regenerative><regenerative cell><repair><repaired><resistant><response><restoration><self-renew><self-renewal><single cell mRNA sequencing><social role><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell characteristics><stem cell organoids><stem cell regeneration><stem cell self renewal><stem cell-derived organoids><stem cells><stem like cancer cell><stem-like><stemness><therapeutic outcome><therapeutic target><therapy outcome><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptional reprogramming><transcriptome sequencing><transcriptomic sequencing><transcriptomics><tumor><tumor cell metastasis><tumor initiation><tumor progression><tumor suppressor><whole genome><wound healing><wound recovery><wound resolution><xeno-transplant><xeno-transplantation>
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Jatin Roper

DUKE UNIVERSITY, DURHAM, NC

Exploratory lead · 32/100
Solid budget
Recent
Active award
$368,288
FY 2026

Project Title

Wnt signaling in obesity-associated colorectal cancer

Grant Number:

5R37CA259363-05

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/23/2022

End Date:

2/28/2027

Project Abstract

Project Summary Obesity affects 42% of the U.S. population and is a major risk factor for the development of colorectal cancer. Obese colorectal cancer patients have a five-fold increased risk of death compared to normal weight counterparts. However, the mechanisms by which obesity increases colorec...

Research Terms

<APC - Adenomatous Polyposis Coli><APC Protein><APC gene><APC genes><APC tumor suppressor><Adenomatosis Polyposis Coli Gene><Adenomatous Polyposis Coli><Adenomatous Polyposis Coli Protein><Affect><Agonist><American><Anti-Oncogenes><Antioncogenes><Assay><BMI><BMI percentile><BMI z-score><Beta Cadherin-Associated Protein><Beta-1 Catenin><Bioassay><Biological Assay><Biotech><Biotechnology><Body mass index><Bowel Cancer><CRISPR approach><CRISPR based approach><CRISPR editing screen><CRISPR method><CRISPR methodology><CRISPR screen><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based screen><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 screen><CRISPR/Cas9 technology><CUL-2><Cancer Model><Cancer Suppressor Genes><CancerModel><Cancers><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><ChIP assay><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Colon><Colon Cancer><Colon Carcinoma><Colon Neoplasms><Colon Tumor><Colonic Mass><Colonic Neoplasms><Colonic Tumor><Colorectal Cancer><Colorectal Neoplasms><Colorectal Tumors><DP2.5><Data><Development><Disease><Disorder><Emerogenes><Family><GDP Dissociation Factor><GDP Dissociation Stimulators><GDP Exchange Factors><GDP-GTP Exchange Protein><GDP-GTP Reversing Factors><GEM model><GEMM model><GI Stem cell><GTP><GTP GDP exchange factor><GTP Phosphohydrolases><GTPases><Gene Transcription><Genes><Genetic Transcription><Genetically Engineered Mouse><Goals><Guanine Nucleotide Exchange Factors><Guanine Nucleotide Exchange Protein><Guanine Nucleotide Releasing Factors><Guanosine Triphosphate><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Guanyl-Nucleotide Exchange Factor><Guanyl-Nucleotide Releasing Factor><HG38><Hepatic Neoplasm Secondary><Hepatic metastasis><High Fat Diet><In Vitro><Incidence><Intestinal><Intestinal Cancer><Intestinal Neoplasia><Intestinal Neoplasms><Intestinal Tumor><Intestines><Intestines Neoplasms><Intracellular Communication and Signaling><KRAS(G12D)><KRASG12D><LGR5><LGR5 gene><Large Bowel Tumor><Large Intestine Neoplasm><Large Intestine Tumor><Leanness><Liver secondaries><Liver secondary cancer><Maintenance><Malignant Intestinal Neoplasm><Malignant Intestinal Tumor><Malignant Neoplasms><Malignant Tumor><Mediating><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Liver><Metastatic Tumor><Metastatic Tumor to the Liver><Metastatic malignant neoplasm to liver><Mice><Mice Mammals><Murine><Mus><Nature><Neoplasm Metastasis><Nuclear Translocation><Obesity><Onco-Suppressor Genes><Oncogenes-Tumor Suppressors><Oncogenesis><Organoids><PPAR delta><PPAR-δ><PPARD protein><PPARdelta><PPARδ><PRO2286><Patients><Peroxisome Proliferator-Activated Receptor delta><Peroxisome Proliferator-Activated Receptor δ><Population><Preventative strategy><Prevention strategy><Preventive strategy><Progenitor Cells><Protocol><Protocols documentation><Quetelet index><RNA Expression><Recessive Oncogenes><Research><Risk Factors><Role><Secondary Neoplasm><Secondary Tumor><Signal Transduction><Signal Transduction Systems><Signaling><Testing><Therapeutic><Thinness><Tissue Sample><Transcription><Transducers><Transplantation><Tumor Suppressing Genes><Tumor Suppressor Genes><WNT Signaling Pathway><WNT signaling><Weight><adiposity><beta cat><beta catenin><biological signal transduction><bowel><cancer in the colon><cancer initiation><cancer metastasis><cancer progenitor><cancer progenitor cells><cancer progression><cancer stem cell><cancer stem like cell><cancer type><chromatin immunoprecipitation><clustered regularly interspaced short palindromic repeats screen><cohort><colon cancer patients><colon cancer tumorigenesis><colon carcinogenesis><colon neoplasia><colon tumorigenesis><colorectal cancer patients><colorectal cancer progression><colorectal cancer therapy><colorectal cancer treatment><colorectal carcinogenesis><colorectal neoplasia><colorectal tumorigenesis><corpulence><death risk><developmental><diet control><diet-associated obesity><diet-induced obesity><diet-related obesity><dietary control><exchange factor><gastrointestinal stem cell><genetically engineered mouse model><genetically engineered murine model><guanosinetriphosphatase><gut progenitor><gut stem cell><in vivo><inhibitor><innovate><innovation><innovative><intestinal progenitor><intestinal stem cells><intestine cancer><large bowel neoplasm><liver metastases><loss of function><malignancy><malignant intestine neoplasm><malignant intestine tumor><malignant liver neoplasm, specified as secondary><malignant progenitor><malignant stem cell><member><metastasis in the liver><metastasis to the liver><metastasize to the liver><metastatic cancer to liver><metastatic liver><metastatic liver neoplasm><mortality><mortality risk><mouse model><murine model><neoplasm progression><neoplasm/cancer><neoplastic progression><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><obese individuals><obese people><obese person><obese population><obese subjects><oncogenic progenitor><oncogenic stem cells><oncosuppressor gene><pre-clinical><preclinical><progenitor cell expansion><progenitor cell function><progenitor cell proliferation><progenitor cell regeneration><progenitor cell self renewal><progenitor expansion><progenitor function><progenitor like cancer cell><progenitor proliferation><progenitor regeneration><progenitor self renewal><programs><restoration><rho><rho G-Proteins><rho GTP-Binding Proteins><rho GTPases><rho Protein P21><rho Small GTP-Binding Proteins><scRNA sequencing><scRNA-seq><secondary liver malignancy><secondary malignant liver neoplasm><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell expansion><stem and progenitor cell function><stem and progenitor cell proliferation><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor function><stem cell expansion><stem cell function><stem cell proliferation><stem cell regeneration><stem cell self renewal><stem cells><stem like cancer cell><therapeutic target><transplant><transplant model><treatment strategy><tumor cell metastasis><tumor initiation><tumor progression><tumorigenesis><weights><β-catenin>
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Peter van Galen

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 32/100
Solid budget
Recent
Active award
$268,500
FY 2026

Project Title

Integrative Single-Cell Analysis of Aging-Associated Changes in Human Hematopoietic Stem Cell Heterogeneity

Grant Number:

1R21HL184189-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT The global population is aging rapidly, with the number of people over 65 expected to double by 2050. Aging alters hematopoietic stem cells (HSCs), leading to increased inflammation, immune dysfunction, and clonal hematopoiesis. These changes have been linked to hematologica...

Research Terms

<(TNF)-α><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AP-1><AP-1 Enhancer-Binding Protein><AP1><AP1 protein><Acceleration><Activator Protein-1><Active Follow-up><Address><Age><Aged 65 and Over><Aging><Algorithms><Automobile Driving><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Body Tissues><Cachectin><Cancers><Cardiovascular Diseases><Cell Body><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Signaling><Cells><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Communities><Complex><Consensus><Data><Data Set><Development><Differential Gene Expression><Disease><Disorder><Dysfunction><Enhancer-Binding Protein AP1><Exhibits><Foundations><Functional disorder><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><General Transcription Factor Gene><General Transcription Factors><Genes><Goals><HSC aging><HSC heterogeneity><HSC quiescence><HSC subsets><Health><Heart><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell heterogeneity><Hematopoietic Stem Cell subsets><Hematopoietic progenitor subsets><Hematopoietic stem cells><Heterogeneity><Homeostasis><Human><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunes><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Increase lifespan><Individual><Infection><Inflammation><Inflammatory><Intervention><Intracellular Communication and Signaling><Investigators><Knowledge><Laboratories><Link><Lung><Lung Diseases><Lung Respiratory System><Macrophage-Derived TNF><Malignant Neoplasms><Malignant Tumor><Meta-Analysis><Mission><Modern Man><Molecular><Monocyte-Derived TNF><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><NHLBI><NIH><National Heart, Lung, and Blood Institute><National Institutes of Health><Organism><Outcome><Pathway interactions><Persons><Physiological Homeostasis><Physiopathology><Population><Preparation><Proliferating><Public Health><Pulmonary Diseases><Pulmonary Disorder><Reproducibility><Research><Research Personnel><Researchers><Resolution><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><System><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Technology><Testing><Therapeutic Intervention><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Transcription Factor AP-1><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><United States National Institutes of Health><Work><above age 65><active followup><advanced analytics><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age associated alterations><age associated changes><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age linked><age of 65 years onward><age related><age related alterations><age related changes><age specific><age specific alterations><age specific changes><aged><aged 65 and greater><aged 65+><aged ≥65><ages><aging associated><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><analyze gene expression><biological signal transduction><biological systems><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell heterogeneity><blood stem cell quiescence><blood-forming stem cell><boost longevity><cardiac repair><cardiovascular disorder><cardiovascular risk><cardiovascular risk factor><cell type><changes with age><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><community empowerment><computational pipelines><cytokine><developmental><differential expression><differentially expressed><discover genes><disease of the lung><disorder of the lung><driving><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><fitness><follow up><follow-up><followed up><followup><foster longevity><gene conservation><gene discovery><gene expression analysis><gene expression assay><heart repair><hematopoietic cell clones><hematopoietic progenitor><hematopoietic stem cell aging><hematopoietic stem cell clonality><hematopoietic stem cell quiescence><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><heterogeneity within hematopoietic stem cells><heterogeneous blood stem cells><heterogeneous hematopoietic stem cells><human data><human old age (65+)><improve lifespan><improve longevity><improved><innovate><innovation><innovative><insight><intervention therapy><lifespan extension><living system><lung disorder><malignancy><member><mouse model><murine model><myeloid precursor><myeloid stem and progenitor cell><neoplasm/cancer><next generation><over 65 years><pathophysiology><pathway><preparations><progenitor biology><progenitor cell biology><progenitor cell pool><progenitor cell population><progenitor pool><progenitor population><programs><prolong lifespan><prolong longevity><promote lifespan><promote longevity><quantification of aging><resolutions><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor biology><stem and progenitor cell population><stem cell biology><stem cell pool><stem cell population><support longevity><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><transcription factor><transcriptional differences><transcriptional profiling><transcriptomics><≥65 years>
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YUSUKE MARIKAWA

UNIVERSITY OF HAWAII AT MANOA, HONOLULU, HI

Exploratory lead · 30/100
Very recent
Active award
$156,500
FY 2026

Project Title

New approach methodologies using stem cell morphogenesis models for preclinical developmental toxicity screening

Grant Number:

1R03ES037055-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/9/2026

End Date:

4/8/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Proposal Abstract Traditionally, live animals have been used to assess the toxicity of candidate chemicals in pharmaceutical drug development. However, animal tests are increasingly scrutinized for being time- consuming, costly, and ethically challenging. This has driven demand for non-animal alter...

Research Terms

<ACT2><AT744.1><Act-2><Address><Adoption><Adverse drug effect><Affect><Animal Testing><Animals><Assay><Benchmarking><Best Practice Analysis><Bioassay><Biological Assay><Birth Defects><Blood Plasma><CCL4><CCL4 gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chemicals><Chemokine (C-C Motif) Ligand 4><Chemokine, CC Motif, Ligand 4><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Consumption><Data><Detection><Development><Dimensions><Drug Exposure><Drugs><Embryo><Embryo Deaths><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Embryonic Induction><Ensure><Erinaceidae><Ethics><Event><Exhibits><Exposure to><Expression Signature><FDA Modernization Act><Foundations><Future><Gene Expression><Gene Expression Profile><Goals><Guidelines><Hedgehog (Hh) signal transduction pathway><Hedgehogs><Human><Human Biology><Immune Activation 2><In Vitro><Individual><International><Intracellular Communication and Signaling><Ligands><Link><MIP1B><MIP1B1><Macrophage Inflammatory Protein 1-Beta><Medication><Mice><Mice Mammals><Miscarriage><Modeling><Modern Man><Molecular><Molecular Target><Morphogenesis><Morphologic Finding><Morphology><Murine><Mus><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Plasma><Plasma Serum><Pluripotent Stem Cells><Pre-Clinical Model><Preclinical Models><Preclinical Testing><Process><Progenitor Cells><Publishing><Regulatory approval><Reticuloendothelial System, Serum, Plasma><Rodent><Rodentia><Rodents Mammals><SCYA4><Screening procedure><Sensitivity and Specificity><Signal Transduction><Signal Transduction Systems><Signaling><Small Inducible Cytokine A4><Spontaneous abortion><Stem Cell Assay><Testing><Time><Toxic effect><Toxicities><Toxicity Testing><Toxicity Tests><Toxicokinetics><Transgenic Organisms><Validation><assess effectiveness><benchmark><biological signal transduction><candidate identification><cost><determine effectiveness><developmental><developmental toxicity><drug candidate><drug development><drug-related adverse effects><drug/agent><effectiveness assessment><effectiveness evaluation><effectiveness validation><ethical><evaluate effectiveness><examine effectiveness><gene expression pattern><gene expression signature><genome scale><genome-wide><genomewide><hedgehog signaling><hedgehog signaling pathway><hh signaling pathway><human derived pluripotent stem cell><human model><human pluripotent stem cell><human progenitor><human stem cells><in vitro Assay><in vivo><innovate><innovation><innovative><insight><malformation><model of human><morphogenetic process><morphological criteria><morphological signature><mouse model><murine model><new alternative methodologies><new alternative methods><new approach methodologies><new approach methods><non-animal alternatives><non-animal approaches><non-animal methods><non-animal model><novel alternative methodologies><novel alternative methods><novel approach methodologies><novel approach methods><pharmaceutical><pluripotent progenitor><pre-clinical><pre-clinical testing><preclinical><progenitor cell assay><progenitor cell gene><progenitor gene><regulatory authorization><regulatory certification><regulatory clearance><reproductive toxicity><response><safety assessment><screening><screening tools><screenings><smoothened signaling pathway><stem cell genes><stem cell technology><stem cell-based assay><stem cells><transcriptional profile><transcriptional signature><transcriptomics><transgenic><validate effectiveness><validations>
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Chandler Walker

RLR VA MEDICAL CENTER, INDIANAPOLIS, IN

Exploratory lead · 30/100
Recent
Active award
Team-scale grant
$0
FY 2026

Project Title

Combining transspinal electrical stimulation and adipose-derived stem cell secretome as a therapy for ALS

Grant Number:

1I21RX005155-01A1

Activity Code:

I21

Mechanism:

Research Centers

Agency:

VA

Start Date:

1/1/2026

End Date:

12/31/2027

Project Abstract

Abstract Amyotrophic lateral sclerosis (ALS) is a devastating and fatal neuromuscular disease that places extreme financial, physical, and emotional burdens on affected Veterans and their caregivers. Currently, ALS remains without a cure and is commonly diagnosed at advanced disease stages when trea...

Research Terms

<ALS patients><ALS therapy><ALS treatment><Activities of Daily Living><Activities of everyday life><Affect><Age><American><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Amyotrophic Lateral Sclerosis patients><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Animals><Anodes><Apoptosis><Apoptosis Pathway><Behavioral><Biological Markers><Blood Serum><Blood Vessels><Body Tissues><CNS plasticity><Care Givers><Caregivers><Cell Body><Cells><Characteristics><Clinical Research><Clinical Study><Combined Modality Therapy><Conditioned Culture Media><Conditioned Medium><Degenerative Neurologic Disorders><Diagnosis><Diathesis><Disease><Disease Progression><Disease susceptibility><Disorder><E-stim><Electric Stimulation><Electrophysiology><Electrophysiology (science)><Emotional><Endothelium><Extremities><Family><Fat progenitor cell><Fat stem cell><Funding><Gastrocnemius Muscle><Gehrig's Disease><Generalized Growth><Goals><Grip strength><Growth><Growth Agents><Growth Factor><Growth Substances><Hand Strength><Hereditary><Hindlimb><Histologic><Histologically><Increase lifespan><Inflammatory><Inherited><Lab Findings><Laboratory Finding><Legal patent><Life><Limb structure><Limbs><Lou Gehrig Disease><Lower Extremity><Lower Limb><Lumbar Portion of Spinal Cord><Lumbar Spinal Cord><Lumbar spinal cord structure><Measures><Mediating><Medulla Spinalis><Membrum inferius><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mice><Mice Mammals><Motor><Motor Cell><Motor Neurons><Multimodal Therapy><Multimodal Treatment><Murine><Mus><Muscle><Muscle Tissue><Myoneural Junction><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Nervous System Physiology><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic><Neurologic Degenerative Conditions><Neurologic Disorders><Neurologic function><Neurological><Neurological Disorders><Neurological function><Neuromuscular Diseases><Neuromuscular Junction><Neuron Degeneration><Neuronal Plasticity><Neurons><Neurophysiology / Electrophysiology><Neurostimulation procedures of spinal cord tissue><Non-Trunk><Onset of illness><Outcome><Palsy><Paralysed><Patents><Pathogenesis><Plegia><Programmed Cell Death><Proteins Growth Factors><QOL><QOL improvement><Quality of life><Risk><SOD-1><SOD-1 protein><SOD1><SOD1 gene><SOD1 gene product><Serum><Severity of illness><Spinal><Spinal Cord><Spinal Cord Stimulation><Symptoms><Testing><Therapeutic><Therapeutic Effect><Tissue Growth><Tissues><Training><Veterans><adipocyte progenitors><adipocyte stem cell><adipocyte-derived stem cell><adipose derived stem cell><adipose progenitor><adipose stem cell><adipose tissue derived stem cell><adipose tissue stem cells><advanced disease><advanced illness><ages><amyotrophic lateral sclerosis therapy><amyotrophic lateral sclerosis treatment><bio-markers><biologic marker><biomarker><boost longevity><central nervous system plasticity><clinical applicability><clinical application><clinical relevance><clinically relevant><cohort><combination therapy><combined modality treatment><combined treatment><daily living function><daily living functionality><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><disease onset><disease severity><disorder onset><electromyostimulation><electrophysiological><electrostimulation><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><fat derived stem cell><foster longevity><functional ability><functional capacity><functional outcomes><gastrocnemius><high risk><improve lifespan><improve longevity><improved><improved outcome><improvements in QOL><improvements in quality of life><in vivo><ineffective therapies><ineffective treatment><innervation><liability to disease><life span><lifespan><lifespan extension><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><military veteran><model of animal><motoneuron><motor disease><motor disorder><motor dysfunction><mouse model><multi-modal therapy><multi-modal treatment><murine model><muscular><mutant><myoneural disorder><nerve supply><nervous system function><neural degeneration><neural plasticity><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neurological disease><neuromuscular><neuromuscular Electrical Stimulation><neuromuscular degenerative disorder><neuromuscular disorder><neuromuscular stimulation><neuronal><neuronal degeneration><neuronal survival><neuroplastic><neuroplasticity><neuroprotection><neuroprotective><ontogeny><paralysis><paralytic><pre-clinical><preclinical><preservation><prognostic of overall survival><prognostic of survival><prolong lifespan><prolong longevity><promote lifespan><promote longevity><protective factors><quality of life improvement><superoxide dismutase 1><support longevity><survival outcome><survival prognosis><symptom treatment><symptomatic treatment><therapeutic target><treat symptom><vascular><veteran population>
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MARK H. TUSZYNSKI

VA SAN DIEGO HEALTHCARE SYSTEM, SAN DIEGO, CA

Exploratory lead · 30/100
Recent
Active award
Team-scale grant
$0
FY 2026

Project Title

RR&D Gordon Mansfield Spinal Cord Injury Consortium

Grant Number:

2I50RX001706-12

Activity Code:

I50

Mechanism:

Research Centers

Agency:

VA

Start Date:

7/1/2015

End Date:

12/31/2030

Project Abstract

This project aims to develop a neural stem cell (NSC) therapy to repair the injured spinal cord and support functional recovery. In the proposed work, we aim to advance this program through a pre-IND filing and to a later IND-enabling stage. Moreover, we aim to continue to develop and optimize poten...

Research Terms

<Analgesia Tests><Anatomic Sites><Anatomic structures><Anatomy><Axon><Bilateral><Biodistribution><Bruise><CNS Nervous System><California><Cell Body><Cell Line><CellLine><Cells><Central Nervous System><Cervical Injury><Cervical Portion of Spinal Cord><Cervical Spinal Cord><Cervical spinal cord injury><Cervical spinal cord structure><Chronic><Clinical Trials><Collaborations><Combined Modality Therapy><Common Rat Strains><Contusions><Data><Development><Distal><ES Cell Line><Electrodes><Embryonic Stem Cell Line><Forelimb><Foundations><Funding><Future><Graft Survival><Grips><Hand><Hour><Human><Human Cell Line><IND Filing><IND application><IND package><IND submission><Injury><Intervention><Investigational New Drug Application><Investigators><Investments><Laboratories><Lead><Lesion><Life><Locomotor Activity><M mulatta><M. mulatta><Macaca mulatta><Macaca rhesus><Measures><Mediating><Medical Rehabilitation><Medical center><Medulla Spinalis><Modeling><Modern Man><Monkeys><Motor Activity><Multimodal Therapy><Multimodal Treatment><Muscle><Muscle Tissue><Natural regeneration><Neural Stem Cell><Neuraxis><Nociception Tests><Outcome><Pain Assessment><Pain Measurement><Pain measure><Pb element><Pre IND FDA meeting><Pre-IND mtg><Preparedness><Primates><Primates Mammals><Progenitor Cells><Rat><Rats Mammals><Rattus><Readiness><Recovery of Function><Regeneration><Rehabilitation><Rehabilitation device><Rehabilitation therapy><Reproducibility><Research><Research Personnel><Researchers><Rhesus Macaque><Rhesus Monkey><Robotics><Rodent><Rodent Model><Rodentia><Rodents Mammals><Safety><Sampling><San Francisco><Site><Spinal><Spinal Cord><Spinal Cord Contusions><Spinal Cord Trauma><Spinal Trauma><Spinal cord injured><Spinal cord injury><Strains Cell Lines><Synapses><Synaptic><Technology><Toxic effect><Toxicities><Training><Translating><Translations><Traumatic Myelopathy><Veterans><Work><axon growth><axonal growth><clinical relevance><clinical validation><clinically relevant><combination therapy><combined modality treatment><combined treatment><cultured cell line><design><designing><develop therapy><developmental><effective therapy><effective treatment><efficacy testing><experiment><experimental research><experimental study><experiments><functional improvement><functional outcomes><functional recovery><grasp><hESC><hand function rehabilitation><hand function restoration><hand rehab><hand rehabilitation><hands><heavy metal Pb><heavy metal lead><human ES cell><human ES cell lines><human ESC><human embryonic stem cell><human embryonic stem cell line><hypoimmunity><immune deficiency><immunodeficiency><improve function><improve hand function><improved><improved functional outcomes><improvement in hand function><injuries><injury and repair><innovate><innovation><innovative><intervention development><lead candidate><meeting><meetings><multi-modal therapy><multi-modal treatment><muscular><nerve stem cell><neural><neural circuit><neural circuitry><neural control><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural regulation><neural stem and progenitor cells><neurocircuitry><neurogenic progenitors><neurogenic stem cell><neuromodulation><neuromodulatory><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><neuroregulation><non-human primate><nonhuman primate><pain assay><pre-IND consultation><pre-IND discussion><pre-IND meeting><pre-Investigational New Drug meeting><progenitor and neural stem cells><progenitor biology><progenitor cell based therapy><progenitor cell biology><progenitor cell survival><progenitor cell therapy><progenitor cell treatment><progenitor survival><progenitor therapy><progenitor treatment><programs><recover hand function><recovery of hand function><regenerate><rehab device><rehab strategy><rehab therapy><rehabilitation paradigm><rehabilitation strategy><rehabilitative><rehabilitative paradigms><rehabilitative therapy><repair><repaired><response><restore hand function><skills><spasticity><stem and progenitor biology><stem and progenitor cell therapy><stem cell based therapy><stem cell biology><stem cell mediated therapy><stem cell survival><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><synapse><synapse formation><synaptic circuit><synaptic circuitry><synaptogenesis><synergism><therapy development><translation><treatment development>
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Xiangdong William Yang

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 26/100
Solid budget
Active award
$374,000
FY 2026

Project Title

Hematopoietic Stem Cell-based CAR Macrophage for Alzheimer's Disease

Grant Number:

5R61AG090398-02

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2026

Project Abstract

Abstract Alzheimer’s disease (AD), characterized by amyloid beta (Aβ) plaque accumulation, remains a formidable challenge due to limited therapeutic interventions. Despite recent FDA approvals, Aβ targeting antibodies fail to significantly impact the clinical progression of cognitive decline and the...

Research Terms

<AD dementia><AD model><AD pathology><AD therapy><AD treatment><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Aducanumab><Age><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's therapy><Alzheimers Dementia><Amyloid><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animals><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibodies><Antibody Therapy><Antigen Presentation><Antigens><Autoimmune><Aβ><BIIB037><Binding><Blood><Blood - brain barrier anatomy><Blood Precursor Cell><Blood Reticuloendothelial System><Blood-Brain Barrier><Body Tissues><Brain><Brain Nervous System><CAR T cell therapy><CAR T cells><CAR T therapy><CAR modified T cells><CAR-T><CAR-Ts><CNS Diseases><CNS Nervous System><CNS disorder><Cancer Treatment><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Central Nervous System Diseases><Central Nervous System Disorders><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communicable Diseases><Contracting Opportunities><Contracts><Degenerative Neurologic Disorders><Deposit><Deposition><Development><Disease><Disease Progression><Disorder><Disturbance in cognition><Encephalon><Engineering><Engraftment><FDA approved><Fibrosis><Germinoblastic Sarcoma><Germinoblastoma><Gliosis><HIV><HIV Infections><HIV viral infection><HIV virus infection><HIV-1 infection><HSC transplantation><Hemato-Encephalic Barrier><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Hortega cell><Human Immunodeficiency Viruses><Image><Immune><Immune Regulators><Immune mediated therapy><Immunes><Immunoassay><Immunologic Receptors><Immunological Receptors><Immunologically Directed Therapy><Immunomodulators><Immunotherapy><Impaired cognition><In Vitro><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Infectious Diseases><Infectious Disorder><Inflammation><Inflammatory><Intracellular Communication and Signaling><LAV-HTLV-III><Lead><Lymphadenopathy-Associated Virus><Lymphoma><Macrophage><Malignant Cell><Malignant Lymphoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mediating><Membrane><Microglia><Modification><Molecular Interaction><Multiple Myeloma><Mφ><NHP models><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neuritic Plaques><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Pathologic><Patients><Pb element><Penetration><Phagocytosis><Phase><Plasma-Cell Myeloma><Primary Senile Degenerative Dementia><Production><RNA Seq><RNA sequencing><RNAseq><Receptor Cell><Regimen><Research><Reticulolymphosarcoma><Safety><Senile Plaques><Signal Transduction><Signal Transduction Systems><Signaling><Structure><T cells for CAR><Technology><Therapeutic><Therapeutic Intervention><Tissues><Transplantation><Treatment Efficacy><Viral><Viral Burden><Viral Load><Viral Load result><Virus-HIV><Work><a beta peptide><abeta><abeta accumulation><abeta aggregation><aduhelm><ages><alzheimer model><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid beta plaque><amyloid β accumulation><amyloid β aggregation><amyloid-b plaque><amyloid-b protein><anti-cancer therapy><antibody based therapies><antibody treatment><antibody-based therapeutics><antibody-based treatment><aβ accumulation><aβ aggregation><aβ plaques><behavior outcome><behavioral outcome><beta amyloid fibril><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood stem cell transplantation><blood-forming stem cell><bloodbrain barrier><cancer cell><cancer microenvironment><cancer therapy><cancer-directed therapy><chimeric antigen T cell receptor><chimeric antigen receptor><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cell therapy><chimeric antigen receptor T cells><chimeric antigen receptor T therapy><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><chronic disorder><cognitive dysfunction><cognitive loss><conditioning><cored plaque><cytokine><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><determine efficacy><develop therapy><developmental><diffuse plaque><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy testing><evaluate efficacy><examine efficacy><gitter cell><heavy metal Pb><heavy metal lead><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><human immunodeficiency virus infection><humanized mice><humanized mouse><imaging><immune modulators><immune receptor><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunomodulatory molecules><immunoregulator><immunoregulatory molecules><improved><in vivo><infected with HIV><infected with human immunodeficiency virus><inflammatory environment><inflammatory milieu><innovate><innovation><innovative><intervention development><intervention efficacy><intervention therapy><lead candidate><leukemia><malignancy><membrane structure><mesoglia><microglial cell><microgliocyte><mouse model><murine model><myeloma><myelomatosis><neoplasm/cancer><neural inflammation><neurodegenerative illness><neuroinflammation><neuroinflammatory><neuropathologic><neuropathological><neuropathology><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><non-human primate><nonhuman primate><nonhuman primate models><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><perivascular glial cell><pre-clinical study><preclinical study><primary degenerative dementia><response><senescence><senescent><senile dementia of the Alzheimer type><side effect><soluble amyloid precursor protein><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy development><therapy efficacy><trafficking><transcriptome sequencing><transcriptomic sequencing><transplant><treatment development><tumor microenvironment>
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Anjie Zhen

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 26/100
Solid budget
Active award
$374,000
FY 2026

Project Title

Hematopoietic Stem Cell-based CAR Macrophage for Alzheimer's Disease

Grant Number:

5R61AG090398-02

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2026

Project Abstract

Abstract Alzheimer’s disease (AD), characterized by amyloid beta (Aβ) plaque accumulation, remains a formidable challenge due to limited therapeutic interventions. Despite recent FDA approvals, Aβ targeting antibodies fail to significantly impact the clinical progression of cognitive decline and the...

Research Terms

<AD dementia><AD model><AD pathology><AD therapy><AD treatment><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Aducanumab><Age><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease therapy><Alzheimer's pathology><Alzheimer's therapy><Alzheimers Dementia><Amyloid><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animals><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibodies><Antibody Therapy><Antigen Presentation><Antigens><Autoimmune><Aβ><BIIB037><Binding><Blood><Blood - brain barrier anatomy><Blood Precursor Cell><Blood Reticuloendothelial System><Blood-Brain Barrier><Body Tissues><Brain><Brain Nervous System><CAR T cell therapy><CAR T cells><CAR T therapy><CAR modified T cells><CAR-T><CAR-Ts><CNS Diseases><CNS Nervous System><CNS disorder><Cancer Treatment><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Central Nervous System Diseases><Central Nervous System Disorders><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communicable Diseases><Contracting Opportunities><Contracts><Degenerative Neurologic Disorders><Deposit><Deposition><Development><Disease><Disease Progression><Disorder><Disturbance in cognition><Encephalon><Engineering><Engraftment><FDA approved><Fibrosis><Germinoblastic Sarcoma><Germinoblastoma><Gliosis><HIV><HIV Infections><HIV viral infection><HIV virus infection><HIV-1 infection><HSC transplantation><Hemato-Encephalic Barrier><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic stem cells><Hortega cell><Human Immunodeficiency Viruses><Image><Immune><Immune Regulators><Immune mediated therapy><Immunes><Immunoassay><Immunologic Receptors><Immunological Receptors><Immunologically Directed Therapy><Immunomodulators><Immunotherapy><Impaired cognition><In Vitro><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Infectious Diseases><Infectious Disorder><Inflammation><Inflammatory><Intracellular Communication and Signaling><LAV-HTLV-III><Lead><Lymphadenopathy-Associated Virus><Lymphoma><Macrophage><Malignant Cell><Malignant Lymphoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mediating><Membrane><Microglia><Modification><Molecular Interaction><Multiple Myeloma><Mφ><NHP models><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neuritic Plaques><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Pathologic><Patients><Pb element><Penetration><Phagocytosis><Phase><Plasma-Cell Myeloma><Primary Senile Degenerative Dementia><Production><RNA Seq><RNA sequencing><RNAseq><Receptor Cell><Regimen><Research><Reticulolymphosarcoma><Safety><Senile Plaques><Signal Transduction><Signal Transduction Systems><Signaling><Structure><T cells for CAR><Technology><Therapeutic><Therapeutic Intervention><Tissues><Transplantation><Treatment Efficacy><Viral><Viral Burden><Viral Load><Viral Load result><Virus-HIV><Work><a beta peptide><abeta><abeta accumulation><abeta aggregation><aduhelm><ages><alzheimer model><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid beta plaque><amyloid β accumulation><amyloid β aggregation><amyloid-b plaque><amyloid-b protein><anti-cancer therapy><antibody based therapies><antibody treatment><antibody-based therapeutics><antibody-based treatment><aβ accumulation><aβ aggregation><aβ plaques><behavior outcome><behavioral outcome><beta amyloid fibril><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood stem cell transplantation><blood-forming stem cell><bloodbrain barrier><cancer cell><cancer microenvironment><cancer therapy><cancer-directed therapy><chimeric antigen T cell receptor><chimeric antigen receptor><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cell therapy><chimeric antigen receptor T cells><chimeric antigen receptor T therapy><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><chronic disorder><cognitive dysfunction><cognitive loss><conditioning><cored plaque><cytokine><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><determine efficacy><develop therapy><developmental><diffuse plaque><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy testing><evaluate efficacy><examine efficacy><gitter cell><heavy metal Pb><heavy metal lead><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><human immunodeficiency virus infection><humanized mice><humanized mouse><imaging><immune modulators><immune receptor><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunomodulatory molecules><immunoregulator><immunoregulatory molecules><improved><in vivo><infected with HIV><infected with human immunodeficiency virus><inflammatory environment><inflammatory milieu><innovate><innovation><innovative><intervention development><intervention efficacy><intervention therapy><lead candidate><leukemia><malignancy><membrane structure><mesoglia><microglial cell><microgliocyte><mouse model><murine model><myeloma><myelomatosis><neoplasm/cancer><neural inflammation><neurodegenerative illness><neuroinflammation><neuroinflammatory><neuropathologic><neuropathological><neuropathology><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><non-human primate><nonhuman primate><nonhuman primate models><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><perivascular glial cell><pre-clinical study><preclinical study><primary degenerative dementia><response><senescence><senescent><senile dementia of the Alzheimer type><side effect><soluble amyloid precursor protein><success><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy development><therapy efficacy><trafficking><transcriptome sequencing><transcriptomic sequencing><transplant><treatment development><tumor microenvironment>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Maya Pahima

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Exploratory lead · 24/100
Training-friendly
$19,894
FY 2026

Project Title

Germline Stem Cell Establishment and the Role of Dazl in Gametogenesis

Grant Number:

5F31HD111230-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

11/1/2023

End Date:

12/9/2025

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY In all animals, including humans, establishment and maintenance of the germline stem cells (GSCs) is critical for life-long reproductive health and fitness. Yet, how GSCs are specified in vertebrates remains largely unknown. GSCs arise from primordial germ cells (PGCs) and serve to ...

Research Terms

<1-Ethyl-1-nitrosourea><21+ years old><Adopted><Adult><Adult Human><Animals><Antibodies><Apoptotic><Automobile Driving><Biological><Brachydanio rerio><Cannot achieve a pregnancy><Cell Body><Cell Differentiation><Cell Differentiation process><Cells><Cloning><Contraception><Contraceptive methods><Cyst><Danio rerio><Data><Data Set><Development><Difficulty conceiving><ENU><Ethylnitrosourea><Event><Fecundability><Fecundity><Female><Fertility><Fertility Control><Fostering><Gametes><Gametogenesis><Gene Alteration><Gene Mutation><Gene Transcription><Generations><Genes><Genetic><Genetic Models><Genetic Transcription><Genomics><Germ Cells><Germ Lines><Germ-Line Cells><Heterozygote><Human><Infertility><Inhibition of Fertilization><Investigators><Knowledge><Laboratories><Lineage Tracing><Maintenance><Meiosis><Messenger RNA><Modeling><Modern Man><Molecular><N-Ethyl-N-nitrosourea><N-ethyl-N-nitroso-urea><Nitrosoethylurea><Outcome><Ovary><Population><Primordial Germ Cell><Process><Progenitor Cells><Proteins><Publishing><RNA Expression><RNA-Binding Proteins><Reporter Genes><Reproductive Cells><Reproductive Health><Research><Research Personnel><Researchers><Role><Sex Cell><Specific qualifier value><Specified><Stem Cell Development><Structure of primordial sex cell><System><Techniques><Testing><Training><Transcript><Transcription><Transgenic Organisms><Translations><Validation><Vertebrate Animals><Vertebrates><Woman><Zebra Danio><Zebra Fish><Zebrafish><adulthood><biologic><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular differentiation><cellular lineage mapping><cellular lineage tracking><chemotherapy><design><designing><developmental><driving><egg><experiment><experimental research><experimental study><experiments><fertility cessation><fertility loss><gene defect><germ stem cells><germline progenitor><germline progenitor cells><germline stem cells><heterozygosity><induced Cre><inducible Cre><infertile><initial cell><mRNA><male><meiotic><mutant><mutant allele><photoactivation><premature><prematurity><preservation><prevent><preventing><progenitor><progenitor cell development><progenitor cell fate><progenitor cell fate specification><progenitor cell pool><progenitor cell population><progenitor development><progenitor fate><progenitor fate specification><progenitor pool><progenitor population><progenitor specification><protein biomarkers><protein expression><protein markers><reproductive><reproductive development><reproductive fitness><scRNA sequencing><scRNA-seq><sexual cell><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><stem and progenitor cell development><stem and progenitor cell fate><stem and progenitor cell population><stem cell fate><stem cell fate specification><stem cell pool><stem cell population><stem cell specification><stem cells><stem cells in the germline><tool><transgenic><translation><validations><vertebrata><♀><♂>
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Swagata Goswami

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Dietary Control of the Pro-Metastatic Niche in Colorectal Cancer

Grant Number:

4R00CA287057-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/19/2024

End Date:

12/31/2028

Project Abstract

PROJECT SUMMARY Colorectal cancer (CRC) metastasis is a major cause of mortality, yet there is a distinct lack of therapies targeting metastasis. Among the major modifiable external factors known to affect CRC risk are diet and obesity; however, unlike cancer initiation, how pro-obesity high fat die...

Research Terms

<Acceleration><Affect><Antioncogene Protein p53><Automobile Driving><Autoregulation><Bioinformatics><Biology><C-K-RAS><CRISPR><CRISPR/Cas system><Cancer Model><Cancer Patient><CancerModel><Cancers><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell-Mediated Lympholytic Cells><Cell-to-Cell Interaction><Cells><Cellular Metabolic Process><Cellular Tumor Antigen P53><Cessation of life><Clustered Regularly Interspaced Short Palindromic Repeats><Colon><Colonoscopy><Colorectal Cancer><Computer Analysis><Cues><Cytolytic T-Cell><Cytotoxic T Cell><Cytotoxic T-Lymphocytes><DNA mutation><Data><Death><Diet><Dietary Intervention><Disease><Disorder><Educational process of instructing><Educational workshop><Evidence based practice guidelines><Evolution><Exercise><Fibroblasts><Future><GI Stem cell><Genetic Change><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic defect><Genetic mutation><Goals><Hepatic Neoplasm Secondary><Hepatic metastasis><High Fat Diet><Homeostasis><Human><Immune><Immunes><Impairment><Injury><Intracellular Communication and Signaling><Investigation><K-RAS2A><K-RAS2B><K-Ras><K-Ras 2A><K-Ras-2 Oncogene><KO mice><KRAS><KRAS2><KRAS2 gene><Ki-RAS><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Life Style><Lifestyle><Literature><Liver><Liver secondaries><Liver secondary cancer><Lymphatic cell><Lymphocyte><Lymphocytic><MAC393 antigen><MMAC1><MMAC1 protein><Macrophage><Malignant Neoplasms><Malignant Tumor><Mediating><Mentors><Mentorship><Metabolic><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Liver><Metastatic Tumor><Metastatic Tumor to the Liver><Metastatic malignant neoplasm to liver><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutated in Multiple Advanced Cancers 1><Mutation><Mφ><Natural regeneration><Neoplasm Metastasis><Null Mouse><Nutrient availability><Nutrition Interventions><Nutritional Interventions><Obesity><Oncogene K-Ras><Oncogenic><Oncoprotein p53><Operative Procedures><Operative Surgical Procedures><Organoids><Outcome><P53><PHTS gene><PHTS protein><PTEN><PTEN gene><PTEN protein><PTEN1><Pathology><Phase><Phenotype><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Phosphoprotein P53><Phosphoprotein pp53><Physiologic><Physiological><Physiological Homeostasis><Population><Progenitor Cells><Protein TP53><Proteins><RASK2><Recombinant DNA Technology><Recommendation><Regeneration><Regulation><Reporter><Research><Role><SGP-2 protein><SGP2><SP 40,40 protein><Secondary Neoplasm><Secondary Tumor><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell like><Stromal Cells><Stromal Neoplasm><Stromal Tumor><Surgical><Surgical Interventions><Surgical Procedure><System><T-Cells><T-Lymphocyte><TP53><TP53 gene><TRP53><TRPM-2 protein><TRPM2><Teaching><Testing><Therapeutic><Training><Transplantation><Tumor Cell><Tumor Protein p53><Tumor Protein p53 Gene><Workshop><X-ray-inducible protein 8><XIP8 protein><adiposity><apoJ protein><apolipoprotein J><biological signal transduction><cancer cell metabolism><cancer initiation><cancer metabolism><cancer metastasis><cancer microenvironment><cancer progenitor><cancer progenitor cells><cancer progression><cancer risk><cancer stem cell><cancer stem like cell><career><cell metabolism><cellular metabaolism><clusterin><colorectal cancer metastasis><colorectal cancer risk><combat><complement lysis inhibitor><complement-associated protein SP-40,40 protein><computational analyses><computational analysis><computer analyses><conference><convention><corpulence><diet control><diet intervention><diet-associated obesity><diet-induced obesity><diet-related obesity><dietary><dietary control><diets><driver lesion><driver mutation><driving><epidemiology research study><epidemiology study><epidemiology survey><evidence base><evidence based guidelines><evidence based recommendations><gastrointestinal><gastrointestinal stem cell><genetically engineered><genome mutation><gut progenitor><gut stem cell><hepatic body system><hepatic organ system><in vivo><in vivo Model><injuries><innovate><innovation><innovative><insight><intervention design><intestinal epithelium><intestinal progenitor><intestinal stem cells><ionizing radiation-induced protein-8><killer T cell><liver metastases><lymph cell><malignancy><malignant liver neoplasm, specified as secondary><malignant progenitor><malignant stem cell><metabolism measurement><metabolomics><metabonomics><metastasis in the liver><metastasis to the liver><metastasize to the liver><metastatic cancer to liver><metastatic colo-rectal><metastatic colo-rectal cancer><metastatic colo-rectal carcinoma><metastatic colon cancer><metastatic colorectal><metastatic colorectal cancer><metastatic colorectal carcinoma><metastatic liver><metastatic liver neoplasm><mortality><mouse model><murine model><mutated in multiple advanced cancers 1 protein><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><obesity-promoting diet><obesogenic Western-style diet><obesogenic diet><obesogenic high fat diet><obesogenic western diet><oncogenic progenitor><oncogenic stem cells><p53 Antigen><p53 Genes><p53 Tumor Suppressor><phosphatase and tensin homologue on chromosome ten><prevent><preventing><pro-obesity diet><progenitor capacity><progenitor cell like><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor like cancer cell><progenitor niche><progenitor pool><progenitor population><progenitor-like><programs><protein p53><regenerate><regenerative><response><scRNA sequencing><scRNA-seq><secondary liver malignancy><secondary malignant liver neoplasm><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell niche><stem and progenitor cell population><stem cell characteristics><stem cell niche><stem cell pool><stem cell population><stem cells><stem like cancer cell><stem-like><stemness><sulfated glycoprotein 2><summit><surgery><symposia><symposium><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><testosterone-repressed prostate message-2 protein><therapy design><thymus derived lymphocyte><transplant><transplant model><treatment design><tumor><tumor cell metabolism><tumor cell metastasis><tumor initiation><tumor metabolism><tumor microenvironment><tumor progression><v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog>
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Sarah Bowling

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 22/100
Recent
Active award
$249,000
FY 2026

Project Title

Cellular barcoding of developmental hematopoiesis

Grant Number:

5R00HL164969-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/16/2024

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY/ ABSTRACT Hematopoietic stem cells (HSCs) lie at the top of the blood hierarchy and are capable of giving rise to all blood cells of an organism. Consequently, their use has enormous therapeutic potential for the treatment of blood diseases, and generation of HSCs in vitro is a centr...

Research Terms

<21+ years old><Adult><Adult Human><Anatomic Sites><Anatomic structures><Anatomy><Aorta><Area><Automobile Driving><Bar Codes><Behavior><Blood><Blood Cells><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Blood flow><Bone Marrow Purging><Boston><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Catalogs><Cell Body><Cell Lineage><Cells><Children's Hospital><Clinic><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Computer Analysis><Cues><DNA><Data><Data Set><Deoxyribonucleic Acid><Derivation><Derivation procedure><Development><Developmental Biology><Embryo><Embryonic><Endothelial Cells><Endothelium><Engraftment><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Fetal Liver><Gene Transcription><Generalized Growth><Generations><Genes><Genetic Transcription><Goals><Growth><HSC emergence><HSC formation><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematology><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterogeneity><In Vitro><Investigation><Investigators><Knowledge><Lineage Tracing><Location><Maps><Mentors><Mentorship><Mice><Mice Mammals><Molecular><Molecular Fingerprinting><Molecular Profiling><Murine><Mus><Names><Natural regeneration><Organism><Outcome><Output><Pediatric Hospitals><Peripheral Blood Cell><Phase><Physiologic><Physiological><Pluripotent Stem Cells><Postdoc><Postdoctoral Fellow><Preparation><Process><Production><Productivity><Progenitor Cells><Property><Protocol><Protocols documentation><Publishing><RNA Expression><Records><Regeneration><Research><Research Associate><Research Personnel><Research Resources><Researchers><Resolution><Resources><Role><Route><Site><System><Techniques><Technology><Testing><Therapeutic><Time><Tissue Growth><Training><Transcription><Work><adulthood><barcode><blood cell formation><blood cell progenitor><blood disorder><blood formation><blood progenitor><blood stem cell><blood stem cell emergence><blood stem cell formation><blood treatment><blood-forming stem cell><career development><catalog><cell behavior><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular behavior><cellular lineage mapping><cellular lineage tracking><chemotherapy><chip model><chip system><clinical relevance><clinically relevant><computational analyses><computational analysis><computer analyses><developmental><driving><driving force><emergence of hematopoietic stem cells><endothelial progenitor><endothelial progenitor cell><endothelial stem cell><epigenetically><experiment><experimental research><experimental study><experiments><hematopoietic progenitor><hematopoietic progenitor cell formation><hematopoietic progenitor formation><hematopoietic stem cell emergence><hematopoietic stem cell formation><hematopoietic stem progenitor cell><hemogenic endothelium><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><human derived pluripotent stem cell><human pluripotent stem cell><iPS><iPSC><iPSCs><improved><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><leukemia/lymphoma><living system><lymphoma/leukemia><medical college><medical schools><molecular profile><molecular signature><mouse model><multiomics><multiple omics><murine model><myeloablation><name><named><naming><new approaches><next generation><novel approaches><novel strategies><novel strategy><on a chip><on chip><ontogeny><panomics><pluripotent progenitor><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><preparations><progenitor cell function><progenitor function><programs><regenerate><regeneration biology><regenerative biology><research associates><resolutions><school of medicine><skills><social role><stem and progenitor cell function><stem and progenitor function><stem cell function><stem cells><tech development><technology development><tool>
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Senthil Velan Bhoopalan

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

Exploratory lead · 22/100
Recent
Active award
$248,999
FY 2026

Project Title

Hematopoietic stem cell defects in Diamond-Blackfan Anemia

Grant Number:

4R00DK134844-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

2/28/2029

Project Abstract

(PLEASE KEEP IN WORD, DO NOT PDF) Diamond-Blackfan anemia (DBA) is a rare inherited bone marrow failure disorder caused mainly by heterozygous loss-of-function mutations in 24 out of 83 ribosomal protein genes, with RPS19 being the most commonly affected gene. DBA usually presents with isolated eryt...

Research Terms

<0-11 years old><Acceleration><Address><Affect><Allelic Loss><Allo BMT><Allogeneic BMT><Allogeneic Bone Marrow Transplantation><Anemia><Animal Model><Animal Models and Related Studies><Antioncogene Protein p53><Assay><Bioassay><Biological Assay><Biology><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Bone Marrow><Bone Marrow Grafting><Bone Marrow Reticuloendothelial System><Bone Marrow Transplant><Bone Marrow Transplantation><Bone marrow failure><CD34><CD34 gene><CITE sequencing><CITE-seq><CITEseq><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CUT&RUN><Cas nuclease technology><Cell Body><Cells><Cellular Indexing of Transcriptomes and Epitopes by Sequencing><Cellular Tumor Antigen P53><Child><Child Youth><Children (0-21)><Chronic><Cleavage Targets and Release Using Nuclease><Cleavage Under Targets and Release Using Nuclease><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complex><DNA Therapy><DNA mutation><Data><Defect><Development><Diamond-Blackfan anemia><Disease><Disorder><Dysfunction><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Erythrocyte Transfusion><Erythroid><Erythropoiesis><Exhibits><Experimental Models><Failure><Foundations><Functional disorder><Funding><Future><Gene Expression><Gene Proteins><Gene Transcription><Gene Transfer Clinical><Genes><Genetic Change><Genetic Intervention><Genetic Transcription><Genetic defect><Genetic mutation><Glucocorticoids><Goals><HDM2><HPCA1><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterograft><Heterologous Transplantation><Heterozygote><Human><Immune Precipitation><Immunoblotting><Immunodeficient Mouse><Immunoprecipitation><Impairment><In Vitro><Inherited bone marrow failure><Investigation><Loss of Heterozygosity><MDM2><MDM2 gene><MDMX protein><Maintenance><Maps><Marrow Transplantation><Mdm-2 protein><Mediating><Modern Man><Molecular><Mutation><Myelopoiesis><NIH><National Institutes of Health><Oncoprotein MDM2><Oncoprotein p53><P53><Pathway interactions><Patients><Phenotype><Phosphoprotein P53><Phosphoprotein pp53><Physicians><Physiology><Physiopathology><Polycomb><Population><Population Heterogeneity><Process><Production><Protein Deficiency><Protein Gene Products><Protein Subunits><Protein TP53><RNA Expression><RNA Seq><RNA sequencing><RNAseq><RPS19><RPS19 gene><Red Blood Cell Transfusion><Repression><Repressor Proteins><Research><Ribo-seq><Ribonucleoproteins><Ribosomal Proteins><Ribosomal RNA><Ribosomes><Scientist><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Structure><TP53><TP53 gene><TRP53><Testing><Therapeutic><Training><Transcription><Translations><Transplantation><Tumor Protein p53><Tumor Protein p53 Gene><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><United States National Institutes of Health><Western Blotting><Western Immunoblotting><Xenograft><Xenograft procedure><Xenotransplantation><allogeneic bone marrow transplant><allogenic bone marrow transplant><blood cell formation><blood cell progenitor><blood disorder><blood formation><blood progenitor><blood stem cell><blood-forming stem cell><bone marrow allograft><bone marrow failure syndrome><career><cellular indexing of transcriptomes and epitopes by single cell sequencing><cofactor><cytopenia><deficiency of protein><developmental><diverse populations><effective therapy><effective treatment><elderly patient><epigenetically><erythroid development><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genome mutation><genomic therapy><global gene expression><global transcription profile><hematopoietic differentiation><hematopoietic hierarchy><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><heterogeneous population><heterozygosity><human derived model><human derived platform><human derived system><human like model><human like platform><human like system><human model><human specific alternative><human specific model><human specific platform><human specific system><human-based alternative><human-based biological models><human-based model><human-based nonanimal models><human-based platform><human-based research><human-based system><human-based tools><human-centered model><human-centered platform><human-centered research><human-centered system><human-focused research><human-relevant alternative><human-relevant model><human-relevant platform><human-relevant system><improved><in vivo><infancy><infantile><inherited disease of bone marrow failure><insight><kids><loss of function mutation><mdm-2 oncogene protein><mdm2 protein><model of animal><model of human><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><older patient><p53 Antigen><p53 Genes><p53 Tumor Suppressor><p53-Binding Protein MDM2><pathophysiology><pathway><population diversity><progenitor><progenitor biology><progenitor cell biology><progenitor cell function><progenitor cell maintenance><progenitor function><progenitor maintenance><programs><protein blotting><protein p53><rRNA><repressor complex><ribosome footprint profiling><ribosome profiling><ribosomopathy><scRNA sequencing><scRNA-seq><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><stem and progenitor biology><stem and progenitor cell function><stem and progenitor function><stem cell biology><stem cell function><stem cell maintenance><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translation><translatome><transplant><transplant therapy><transplant treatment><transplantation therapy><transplantation treatment><ubiquitin ligase><xeno-transplant><xeno-transplantation><youngster>
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Sushree S Sahoo

VIRGINIA POLYTECHNIC INST AND ST UNIV, BLACKSBURG, VA

Exploratory lead · 22/100
Recent
Active award
$248,999
FY 2026

Project Title

Elucidating function of disease-related SAMD9L mutations in hematopoiesis

Grant Number:

4R00DK135910-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

1/31/2029

Project Abstract

(PLEASE KEEP IN WORD, DO NOT PDF) Germline mutations in SAMD9L are a major cause of inherited bone marrow failure and pediatric myelodysplastic syndrome, frequently associated with poor clinical outcomes. Although these mutations are known to impair hematopoietic stem cell function, the cellular mec...

Research Terms

<0-11 years old><Affect><Autoregulation><Biologic Models><Biological Models><Blood Diseases><Blood Precursor Cell><Bone Marrow Diseases><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Stress><Cellular Stress Response><Child><Child Youth><Children (0-21)><Chronic><Clinical><DNA mutation><Defect><Development><Disease><Disease Progression><Disorder><Dysfunction><Early Diagnosis><Evolution><Foundations><Functional disorder><GEM model><GEMM model><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetically Engineered Mouse><Germ-Line Mutation><Goals><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematology><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Hereditary><Hereditary Mutation><Homeostasis><Impairment><Individual><Inflammation><Inflammatory><Inflammatory Response><Inherited><Inherited bone marrow failure><Intermediary Metabolism><Intervention Strategies><Intracellular Communication and Signaling><Investigators><Link><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Mitochondria><Model System><Modeling><Mutation><Outcome><Pathogenicity><Pathway interactions><Patients><Phase><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Process><Progenitor Cell Transplantation><Progenitor Cells><QOL><Quality of life><Regulation><Regulatory Pathway><Research><Research Personnel><Researchers><Role><Severity of illness><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell Transplantation><Stem cell transplant><Stress><Stress Response Signaling><Therapeutic Intervention><Variant><Variation><Work><adult youth><biological signal transduction><blood cell formation><blood cell progenitor><blood disorder><blood formation><blood progenitor><blood stem cell><blood-forming stem cell><bone marrow disorder><bone marrow failure syndrome><cell stress><children with MDS><developmental><disease severity><early detection><effective therapy><effective treatment><engineered progenitor cells><engineered stem cells><genetically engineered mouse model><genetically engineered murine model><genome mutation><germ-line defect><germline variant><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><improved><induced human pluripotent stem cells><inherited disease of bone marrow failure><intervention therapy><kids><mitochondrial><pathophysiology><pathway><pediatric MDS><pediatric myelodysplastic syndrome><progenitor cell function><progenitor cell survival><progenitor function><progenitor survival><progenitor transplantation><programs><response to therapy><response to treatment><self-renew><self-renewal><social role><stem and progenitor cell function><stem and progenitor cell transplantations><stem and progenitor function><stem cell function><stem cell survival><stem cells><therapeutic response><therapy response><treatment response><treatment responsiveness><young adult><young adult age><young adulthood><youngster>
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Daysha Ferrer Torres

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 22/100
Recent
Active award
$241,593
FY 2026

Project Title

Utilizing a human stem cell model of the esophagus to understand racial disparities during injury repair

Grant Number:

5R00DK133804-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/22/2022

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT African Americans (AA) and European Americans (EA) have a similar prevalence of gastro-esophageal reflux disease (GERD). Nonetheless, when compared to EA, AA show a lower incidence of esophagus damage, metaplasia, and esophageal adenocarcinoma. Population genetics and molecu...

Research Terms

<2-dimensional><3-D><3-Dimensional><3D><AI system><Acid Reflux><Acids><Active Oxygen><Address><Adenocarcinoma of the Esophagus><African American><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><American><Area><Artificial Intelligence><Assay><Autoregulation><Barrett Esophagus><Barrett Syndrome><Barrett Ulcer><Bile><Bile Acids><Bile Juice><Bile fluid><Bioassay><Biologic Models><Biological Assay><Biological Models><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Death><Cell Line><Cell Protection><CellLine><Cells><Cellular injury><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Columnar Epithelial-Lined Lower Esophagus><Columnar-Lined Esophagus><Committee Members><Computer Reasoning><Coupled><Cytoprotection><DNA Damage><DNA Injury><Data><Disease><Disorder><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Drug Screening><Drugs><Enzyme Gene><Enzymes><Epithelium><Esophageal Adenocarcinoma><Esophageal Diseases><Esophageal Disorder><Esophageal Reflux><Esophageal Tissue><Esophageal injury><Esophagitis><Esophagus><European><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fellowship><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><GERD><GSTT2><GSTT2 gene><Gastric Acid><Gastric Hydrochloric Acid><Gastro-oesophageal Reflux><Gastroesophageal Reflux><Gastroesophageal reflux disease><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Genes><Genetic><Glutathione S-Transferase, Theta-2><Goals><Health><Homeostasis><Human><Image><Image Analyses><Image Analysis><In Vitro><Incidence><Individual><Injury><Injury to Esophagus><Investigation><Lead><Libraries><Machine Intelligence><Machine Learning><Mediating><Mediation><Medication><Mentors><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Metaplasia><Metaplastic Change><Methods><Michigan><Model System><Modeling><Modern Man><Modification><Molecular><Molecular Fingerprinting><Molecular Profiling><Molecular Target><Natural Products><Negotiating><Negotiation><Organoids><Oxygen Radicals><Pathway interactions><Patients><Pb element><Pharmaceutical Preparations><Phase><Phenotype><Physiological Homeostasis><Play><Population Genetics><Population Heterogeneity><Postdoc><Postdoctoral Fellow><Predisposition><Prevalence><Pro-Oxidants><Progenitor Cells><Proliferating><Reactive Oxygen Species><Reporting><Research><Research Associate><Research Resources><Resources><Role><Stomach><Strains Cell Lines><Susceptibility><Techniques><Testing><Tissue Sample><Tissues><Training><Transcript Expression Analyses><Transcript Expression Analysis><Universities><Work><analyze gene expression><biobank><biological adaptation to stress><biorepository><cell damage><cell injury><cellular damage><clinical immersion><cohort><critical injury><cultured cell line><cytoprotective><damage to cells><data acquisition><data acquisitions><design><designing><detoxification><devastating injury><diseases of esophagus><disparities in race><disparity due to race><diverse populations><drug discovery><drug/agent><esophageal intestinal metaplasia><esophageal progenitors><esophageal stem cell><esophagus disorder><experiment><experimental research><experimental study><experiments><fitness><gain of function><gastric><gene expression analysis><gene expression assay><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><genome editing><genomic editing><heavy metal Pb><heavy metal lead><heterogeneous population><human progenitor><human stem cells><human tissue><image evaluation><image interpretation><image-based method><imaging><imaging method><imaging modality><in vivo><inequality due to race><inequity due to race><injuries><injury and repair><injury response><injury to cells><loss of function><machine based learning><molecular profile><molecular signature><naturally occurring product><necrocytosis><pathway><population diversity><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><progenitor cell model><progenitor model><programs><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial disparity><racial diversity><racial inequality><racial inequity><racially diverse><racially unequal><reactioncrisis><repair><repaired><research associates><research immersion><response><response to injury><scRNA sequencing><scRNA-seq><screening><screenings><severe injury><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stem cells><stress response><stressreaction><three dimensional><tool><transcriptional profiling><transcriptome profiling><transcriptomic profiling><transcriptomics><two-dimensional><vector>
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MARY Jane KELLEY

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Exploratory lead · 22/100
Recent
Active award
$195,000
FY 2026

Project Title

Enhancing Stem Cell Restoration of IOP Homeostasis by Senolytic Treatments

Grant Number:

5R21EY037045-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Project Abstract

Summary Glaucoma, a major blinding optic neuropathy, is a progressive, debilitating disease with visual field loss. The primary risk factor for the disease, as well as the one and only treatable parameter to delay bilateral blindness and slow the disease is to reduce the elevated intraocular pressu...

Research Terms

<Abscission><Age><Age related pathologies><Aging><Anterior><Aqueous Humor><Assay><Autoregulation><Back><Basement membrane><Bilateral><Bioassay><Biological Assay><Blindness><Body Tissues><Cadaver><Cell Aging><Cell Body><Cell Senescence><Cell Wall><Cells><Cellular Aging><Cellular Senescence><Cellularity><Characteristics><Confocal Microscopy><Cranial Nerve II Diseases><Cranial Nerve II Disorder><Detergents><Disease><Disorder><Dorsum><Drugs><Endothelium><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Excision><Exhibits><Exposure to><Extirpation><Eye><Eye Drops><Eyeball><Eyedrops><Galactosidase><Glaucoma><Goals><H2O2><Homeostasis><Human><Hydrogen Peroxide><Hydroperoxide><Innovative Therapy><Intraocular Fluid><Intraocular Pressure><Laser Electromagnetic><Laser Radiation><Lasers><Measures><Mechanics><Medication><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Methodology><Modality><Modeling><Modern Man><Neural-Optical Lesion><Ocular Tension><Operative Procedures><Operative Surgical Procedures><Optic Nerve Diseases><Optic Neuropathy><Organ Culture><Organ Culture Techniques><Patient Compliance><Perfusion><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phenotype><Physiologic Intraocular Pressure><Physiological Homeostasis><Play><Process><Progenitor Cell Transplantation><Progenitor Cells><Property><Quercetin><Reaction><Regulation><Removal><Replicative Senescence><Resistance><Risk Factors><Role><Saponins><Schlemm's canal><Second Cranial Nerve Diseases><Senotherapeutic><Stem Cell Transplantation><Stem cell transplant><Stents><Stress><Stretching><Structure of sinus venosus of sclera><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><System><Techniques><Telomere Shortening><Testing><Therapeutic><Tissues><Trabecular Meshwork><Trabecular meshwork structure><Transplantation><Visual Fields><age associated pathologies><age dependent pathologies><age induced pathologies><aged><ages><aging associated pathologies><aging dependent pathologies><aging induced pathologies><aging pathologies><aging related pathologies><cadaveric><cadavers><determine efficacy><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><epigenetically><evaluate efficacy><ex vivo perfusion><examine efficacy><eye field><glaucomatous><iPS><iPSC><iPSCs><improved><in vitro Organ Culturing><in vitro vertebrate organ culturing><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intra-ocular pressure><loss of function><mechanic><mechanical><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><mitochondrial dysfunction><ocular hypotensive><optic nerve disorder><patient adherence><patient cooperation><pharmaceutical><preservation><pressure><prevent><preventing><progenitor transplantation><replicative aging><resection><resistant><response><restoration><second cranial nerve disorder><senescence><senescent><senescent cell><senolytics><social role><stem and progenitor cell transplantations><stem cells><surgery><telomere attrition><transplant><vision loss><visual loss>
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Joyce Huanhuan Chen

UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 22/100
Recent
Active award
$191,675
FY 2026

Project Title

Unraveling Metastasis Drivers in Small Cell Lung Cancer via Human Pluripotent Stem Cell-Based Approach

Grant Number:

5R21CA299377-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Project Abstract

SUMMARY Small cell lung cancer (SCLC) is among the most lethal malignancies, noted for its pronounced metastatic potential across solid tumors, yet the underlying mechanisms of its metastasis remain largely unknown. In this project, we aim to deploy innovative methods and tools to delve into the lon...

Research Terms

<ATAC sequencing><ATAC-seq><ATACseq><Abscission><Aggression><Aggressive behavior><Animal Model><Animal Models and Related Studies><Antioncogene Protein p53><Area><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Automobile Driving><Bioassay><Biological><Biological Assay><Body Tissues><Cancer Model><Cancer Patient><Cancer cell line><CancerModel><Cancers><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cells><Cellular Tumor Antigen P53><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Chromosomal Organization><Chromosomal Structure><Chromosome Organization><Chromosome Structures><Clinical><Complex><Development><Diagnosis><Disease><Disorder><Enzyme Gene><Enzymes><Epithelial Cells><Event><Excision><Expression Signature><Extirpation><Family><Gastric Body Cancer><Gastric Cancer><Gastric Cardia Cancer><Gastric Fundus Cancer><Gastric Pylorus Cancer><Gene Expression><Gene Expression Profile><Generations><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genomics><Heart Vascular><Human><In Vitro><Induced DNA Alteration><Induced Mutation><Induced Sequence Alteration><Invaded><Link><Malignant Cell><Malignant Gastric Neoplasm><Malignant Gastric Tumor><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of prostate><Malignant prostatic tumor><Maps><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Metastatic to><Methods><Mice><Mice Mammals><Modeling><Modern Man><Modification><Molecular><Morbidity><Murine><Mus><Mutate><Neoplasm Metastasis><Neuroendocrine Cell><Non-Polyadenylated RNA><Oat cell carcinoma><Oncogenic><Oncoprotein p53><Operative Procedures><Operative Surgical Procedures><Organ><Outcomes Research><P53><PDX model><Patient derived xenograft><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Penetration><Phosphoprotein P53><Phosphoprotein pp53><Population><Primary Neoplasm><Primary Tumor><Process><Prognosis><Prostate CA><Prostate Cancer><Prostate malignancy><Protein TP53><Publishing><RB1><RB1 gene><RNA><RNA Gene Products><Recombinant DNA Technology><Removal><Research><Respiratory Epithelium><Ribonucleic Acid><Role><Sampling><Secondary Neoplasm><Secondary Tumor><Series><Site><Small Cell Lung Cancer><Solid Neoplasm><Solid Tumor><Sorting><Stomach Cancer><Structure of respiratory epithelium><Surface><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><System><TP53><TP53 gene><TRP53><Techniques><Technology><Testing><Tissues><Transposase><Tumor Protein p53><Tumor Protein p53 Gene><Tumor Tissue><Work><airway epithelium><anti-cancer research><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><biologic><cancer cell><cancer initiation><cancer metastasis><cancer progression><cancer research><cancer type><catalyst><cell behavior><cellular behavior><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chromatin modification><chromatin remodeling><circulatory system><developmental><directed differentiation><driving><experiment><experimental research><experimental study><experiments><gastric malignancy><gene expression pattern><gene expression signature><genetically engineered><global gene expression><global transcription profile><human derived pluripotent stem cell><human pluripotent stem cell><improved><in vivo><innovate><innovation><innovative><insight><lung cancer cell><lung oat cell carcinoma><lung small cell neuroendocrine carcinoma><malignancy><malignant stomach neoplasm><malignant stomach tumor><metastatic process><model of animal><mortality><neoplasm progression><neoplasm/cancer><neoplastic progression><new approaches><new diagnostics><new technology><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation diagnostics><novel approaches><novel diagnostics><novel strategies><novel strategy><novel technologies><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><oat cell cancer><overexpress><overexpression><p53 Antigen><p53 Genes><p53 Tumor Suppressor><patient derived xenograft model><patient oriented outcomes><pre-clinical><preclinical><progenitor cell model><progenitor model><programs><protein p53><pulmonary><resection><respiratory tract epithelium><retinoblastoma-1><scATAC sequencing><scATAC-seq><scRNA sequencing><scRNA-seq><single cell ATAC-seq><single cell ATAC-sequencing><single cell Assay for Transposase Accessible Chromatin sequencing><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell sequencing assay for transposase accessible chromatin><single cell transcriptomic profiling><single-cell Assay for Transposase-Accessible Chromatin with sequencing><single-cell RNA sequencing><single-cell assay for transposase-accessible chromatin using sequencing><single-cell assay for transposase-accessible chromatin-seq><small cell lung carcinoma><small cell undifferentiated carcinoma><social role><species difference><stem and progenitor cell model><stem cell approach><stem cell based approach><stem cell based model><stem cell derived model><stem cell method><stem cell methodology><stem cell model><stem cell procedure><stem cell technique><stomach fundus cancer><stomach pylorus cancer><surgery><therapeutically effective><tool><trait><transcriptional profile><transcriptional signature><transcriptome><tumor><tumor cell metastasis><tumor initiation><tumor progression>
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Boris Reizis

UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 22/100
Recent
Active award
$156,825
FY 2026

Project Title

The Mechanism of Hematological Abnormalities in Systemic Autoimmunity

Grant Number:

7R21AR085741-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2027

Project Abstract

ABSTRACT Systemic autoimmune diseases such as systemic lupus erythematosus (SLE) are mediated by autoantibodies against key tissue constituents, accompanied by the activation of innate immune system. In addition, systemic autoimmunity is frequently associated with hematological complications such as...

Research Terms

<Abnormal Cell><Affect><Anemia><Anti-Rejection Therapy><Antibodies><Architecture><Autoantibodies><Autoimmune Status><Autoimmunity><Blood Cells><Blood Platelets><Blood Precursor Cell><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Cell Body><Cell secretion><Cells><Cellular Secretion><Chromatin><Chronic><Clinical><Data><Defect><Disease><Disorder><Endosomes><Engineering / Architecture><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exposure to><Feedback><Future><Genetic><Hematology><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Human><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Immunosuppressive Therapy><Impairment><Inflammation><Inflammatory><Innate Immune System><Interferon Type I><Life><Lineage Tracing><Lupus Erythematosus Disseminatus><Lymphocytopenia><Lymphopenia><Marrow platelet><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Myelogenous><Myeloid><Myeloid Cell Activation><Myeloid Cells><Nature><Non-Polyadenylated RNA><Nuclear Proteins><Nucleic Acids><Pathogenesis><Pathway interactions><Patients><Peripheral Blood Cell><Platelets><Play><Proliferating><RNA><RNA Gene Products><Receptosomes><Ribonucleic Acid><Role><SLE><Signal Induction><Source><Stimulus><Symptoms><Systemic Lupus Erythematosus><Systemic Lupus Erythematous><Systemic Lupus Erythmatosus><TLR7><TLR7 gene><Testing><Therapeutic><Therapeutic immunosuppression><Thrombocytes><Thrombocytopenia><Thrombopenia><Tissues><Toll-Like Receptor 7><Training><Transcript><Transgenic Mice><Upregulation><artificial immunosuppression><autoimmune antibody><autoreactive antibody><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular lineage mapping><cellular lineage tracking><clinical relevance><clinically relevant><cytokine><disseminated lupus erythematosus><epigenetically><epigenome><exhaustion><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><immunosuppression therapy><improved><mouse model><murine model><novel><overexpress><overexpression><pathway><progenitor><progenitor biology><progenitor cell biology><progenitor cell function><progenitor function><reconstitute><reconstitution><self reactive antibody><sensor><social role><stem and progenitor biology><stem and progenitor cell function><stem and progenitor function><stem cell biology><stem cell depletion><stem cell exhaustion><stem cell fatigue><stem cell function><systemic autoimmune disease><systemic autoimmune disorder><systemic autoimmunity><systemic lupus erythematosis>
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Shruti Gupta

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 22/100
Recent
Active award
$141,235
FY 2026

Project Title

Early Detection and Treatment of Hematopoietic Stem Cell Transplant-Associated Thrombotic Microangiopathy (HSCT-TMA)

Grant Number:

5R03DK141708-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/19/2024

End Date:

11/30/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT Hematopoietic stem cell transplant-associated thrombotic microangiopathy (HSCT-TMA) is a common and often devastating condition following allogeneic hematopoietic stem cell transplantation, causing injury to small vessels, particularly in the kidney. HSCT-TMA occurs in 13-4...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Allelism Test><Allogenic><Annexins><Assay><Bioassay><Biological Assay><Biological Markers><Blood Plasma><Blood Sample><Blood Serum><Blood specimen><C3 convertase activator><C3PA Convertase><C3PAse><CDDP><COVID infected patient><COVID patient><COVID positive patient><COVID-19 infected patient><COVID-19 patient><COVID-19 positive patient><COVID19 patient><COVID19 positive patient><Calcimedins><Cancer Center><Cancer Treatment><Cell Body><Cell Death><Cells><Cessation of life><Cis-diammine-dichloroplatinum><Cis-diamminedichloridoplatinum><Cis-diamminedichloro Platinum (II)><Cis-dichloroammine Platinum (II)><Cis-platinous Diamine Dichloride><Cis-platinum II><Cis-platinum II Diamine Dichloride><Cisplatin><Cisplatina><Cisplatinum><Clinical><Clinical Trials><Collaborations><Complement><Complement Activation><Complement Factor D><Complement Factor H><Complement Factor P><Complement Inactivators><Complement Inhibitors><Complement Protein D><Complement Proteins><Complementation Test><Complication><Controlled Study><Cysplatyna><D component of complement><DF/HCC><Dana-Farber Cancer Institute><Data><Death><Detection><Development><Diagnosis><Dichlorodiammineplatinum><Dysfunction><Early Diagnosis><Early identification><Early treatment><Endothelium><FLT VEGF Receptor><FLT1 RTK><FLT1 Receptor Tyrosine Kinase><Factor D><Factor H><Flt-1><Foundations><Functional disorder><Future><GBGase><Genetic Complementation Test><Grant><HSC transplantation><Hematologist><Hematology><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Injury><K23 Award><K23 Mechanism><K23 Program><Kidney><Kidney Replacement Therapy><Kidney Urinary System><Lipocortins><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Measures><Mediating><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Morbidity><Nested Case-Control Study><Observational Study><Outcome><Outcome Study><Pathway interactions><Patients><Peyrone's Chloride><Peyrone's Salt><Physiopathology><Plasma><Plasma Serum><Platinum Diamminodichloride><Preventative therapy><Preventive therapy><Proactivator Convertase><Properdin><Properdin Factor D><Prospective Studies><Prospective cohort><Proto-Oncogene Protein flt><Receptor Tyrosine Kinase,Class V><Renal Replacement Therapy><Research Design><Reticuloendothelial System, Serum, Plasma><Risk><Ristocetin Cofactor><Ristocetin-Willebrand Factor><SARS-CoV-2 infected patient><SARS-CoV-2 patient><SARS-CoV-2 positive patient><Sampling><Serum><Study Type><Testing><Therapeutic><Thrombomodulin><Time><Trans Test><Treatment Efficacy><Tyrosine Protein Kinase FRT><Tyrosine Protein Kinase Receptor FLT><VEGF Receptor flt-1 Protein><VEGFR-1><VEGFR1><Vascular Endothelial Growth Factor Receptor-1><adipocyte 28 kDa protein><adipsin><adulthood><anti-cancer therapy><bio-markers><biobank><biologic marker><biomarker><biorepository><blood stem cell transplantation><cancer therapy><cancer-directed therapy><cis dichlorodiammineplatinum><cis platinum compound><cis-Diaminedichloroplatinum><cis-Diamminedichloroplatinum><cis-Diamminedichloroplatinum(II)><cis-Dichlorodiammineplatinum(II)><cis-Platinum><complement pathway regulation><complementation><complementation analysis><complementation approach><coronavirus disease 2019 infected patient><coronavirus disease 2019 patient><coronavirus disease 2019 positive patient><coronavirus disease infected patient><coronavirus disease patient><coronavirus disease positive patient><coronavirus disease-19 patient><coronavirus patient><design><designing><detection assay><developmental><early biomarkers><early detection><early detection biomarkers><early detection markers><early therapy><efficacy testing><factor P><fms-Like Tyrosine Kinase><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><high risk><improved><improved outcome><injuries><intervention efficacy><mortality><necrocytosis><observational research study><observational survey><pathophysiology><pathway><patient infected with COVID><patient infected with COVID-19><patient infected with SARS-CoV-2><patient infected with coronavirus disease><patient infected with coronavirus disease 2019><patient infected with severe acute respiratory syndrome coronavirus 2><patient with COVID><patient with COVID-19><patient with COVID19><patient with SARS-CoV-2><patient with coronavirus disease><patient with coronavirus disease 2019><patient with severe acute respiratory distress syndrome coronavirus 2><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><predictive panel><prevent><preventing><prospective research study><prospective survey><randomized, clinical trials><renal><severe acute respiratory syndrome coronavirus 2 infected patient><severe acute respiratory syndrome coronavirus 2 patient><severe acute respiratory syndrome coronavirus 2 positive patient><skills><study design><therapeutic efficacy><therapeutically effective><therapy efficacy><thrombotic><von Willebrand Factor><von Willebrand Protein>
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Wade William Sugden

VERSITI BLOOD HEALTH, INC., MILWAUKEE, WI

Exploratory lead · 22/100
Recent
Active award
$127,500
FY 2026

Project Title

Role of Force-directed Lipid Metabolism in the Endothelial-to-Hematopoietic Transition

Grant Number:

1R03DK145931-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2026

End Date:

12/31/2027

Project Abstract

Project Summary/Abstract In vertebrates, self-renewing hematopoietic stem cells (HSCs) are produced from a developmental event called endothelial-to-hematopoietic transition (EHT). EHT consists of a cellular and transcriptional reprogramming that allows hemogenic endothelial cells (HECs) from a subs...

Research Terms

<Ablation><Agonist><Anemia><Animal Genetics><Animal Model><Animal Models and Related Studies><Aorta><Arteries><Atlases><Basal Transcription Factor><Basal transcription factor genes><Biologic Models><Biological Models><Blood><Blood Cells><Blood Circulation><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Blood Vessels><Blood flow><Bloodstream><Body Tissues><Brachydanio rerio><Cardia><Cardiac development><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Division Cycle><Cell Lineage><Cell Nucleus><Cell Reprogramming><Cell Signaling><Cells><Cessation of life><Characteristics><Chemicals><Circulation><Clinical><Complex><Confocal Microscopy><Cues><Cyclicity><Danio rerio><Data><Data Set><Death><Defect><Development><Developmental Process><Discipline><Distant><Dorsal><Edg Receptors><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Artery><Embryonic Development><Embryonic arterial structure><Endothelial Cells><Endothelium><Endowment><Erythroid Cells><Event><Exhibits><Exposure to><Failure><Future><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Generations><Genes><Genetic><Genetic Transcription><Glycolysis><Growth><HSC emergence><HSC production><HSC transplantation><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic><Hematopoietic Cell Production><Hematopoietic Cell Tumor><Hematopoietic Cellular Control Mechanisms><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Hematopoietic stem cells><Hereditary><Image><Impairment><In Vitro><Inherited><Intermediary Metabolism><Intracellular Communication and Signaling><Investigators><Knock-out><Knockout><Lipids><Lymphatic cell><Lymphocyte><Lymphocytic><Lymphoid Cell><Malignant Hematopoietic Neoplasm><Mammalia><Mammals><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Mice><Mice Mammals><Model System><Modeling><Molecular><Molecular Genetics><Morphogenesis><Murine><Mus><Myeloid Cells><Nature><Neural Development><Nucleus><Nutrient><Nutritional><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Pathway interactions><Patients><Periodicity><Peripheral Blood Cell><Population><Process><Production><Progenitor Cell Transplantation><Progenitor Cells><Proteins><Protocol><Protocols documentation><Proxy><Publishing><RNA Expression><Receptor Protein><Regulation><Research Personnel><Researchers><Resolution><Rhythmicity><Role><S1P Receptor><Sampling><Series><Signal Induction><Signal Transduction><Signal Transduction Systems><Signaling><Sorting><Specific qualifier value><Specified><Sphingosine-1-Phosphate Receptor><Stem Cell Transplantation><Stem cell transplant><Stimulus><Stretching><System><Techniques><Technology><Testing><Therapeutic><Time><Tissue Growth><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transducers><Transplantation><Vertebrate Animals><Vertebrates><Visualization><Wound Repair><Zebra Danio><Zebra Fish><Zebrafish><angiogenesis><antagonism><antagonist><biological signal transduction><blood cancer><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell emergence><blood stem cell transplantation><blood-forming stem cell><cancer of blood><cancer of the blood><candidate identification><cardiogenesis><cell fate specification><cell type><cellular reprogramming><cost><curative intervention><curative therapeutic><curative therapy><curative treatments><developmental><emergence of hematopoietic stem cells><fat metabolism><gain of function><gastric cardia><gene function><gene regulatory network><genome editing><genomic editing><global gene expression><global transcription profile><heart development><heart formation><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic gene><hematopoietic hierarchy><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem cell emergence><hematopoietic stem cell production><hematopoietic stem progenitor cell><hemodynamics><hemogenic endothelium><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSCs><imaging><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><interest><leukemia/lymphoma><lipid mediator><lipid metabolism><lipidome><lipidomics><loss of function><lymph cell><lymphoma/leukemia><mechanical force><metabolic profile><migration><model of animal><model organism><monolayer><morphogenetic process><mouse model><multipotency><multipotent><murine model><mutant><neurodevelopment><nutritious><ontogeny><organ development><organ growth><overexpress><overexpression><pathway><progenitor><progenitor transplantation><receptor><reconstitute><reconstitution><resolutions><response><self-renew><self-renewal><social role><sphingosine 1-phosphate><stem and progenitor cell transplantations><stem cells><stomach cardia><success><tool><trait><transcription factor><transcriptional reprogramming><transcriptome><transcriptomics><transplant><vascular><vertebrata><vertebrate embryos><wound healing><wound recovery><wound resolution><zebrafish genome>
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Sarah Palmer Short

UNIVERSITY OF IOWA, IOWA CITY, IA

Exploratory lead · 22/100
Recent
Active award
$116,625
FY 2026

Project Title

Epithelial specific roles for GPx1 in the intestinal microenvironment

Grant Number:

5R03DK141827-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/12/2025

End Date:

2/28/2027

Project Abstract

Project Summary Antioxidant proteins which regulate reactive oxygen species (ROS) are often considered to be protective in the setting of intestinal inflammation and disease, such as inflammatory bowel disease (IBD). Glutathione peroxidase 1 (GPx1) is a ubiquitously expressed selenoenzyme and poten...

Research Terms

<Active Oxygen><Address><Affect><Antioxidants><Attenuated><Award><Biological><Body Tissues><Cancers><Cell Body><Cell Communication and Signaling><Cell Count><Cell Culture Techniques><Cell Number><Cell Signaling><Cells><Cellular Expansion><Cellular Growth><Colitis><Complement><Complement Proteins><Complex><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Data><Development><Disease><Disorder><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Dysplasia><Epithelial Cell Proliferation><Epithelial Cells><Epithelium><Funding><Future><GI Stem cell><Generalized Growth><Grant><Growth><H2O2><HG38><Health><Hydrogen Peroxide><Hydroperoxide><IRES><Immune><Immune infiltrates><Immunes><Immunology><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Injury><Internal Ribosome Entry Segment><Internal Ribosome Entry Site><Intestinal><Intestinal Diseases><Intestinal Disorder><Intestines><Intracellular Communication and Signaling><Investigation><K01 Award><K01 Mechanism><K01 Program><Knowledge><LGR5><LGR5 gene><Link><Lipids><LoxP-flanked allele><Malignant Neoplasms><Malignant Tumor><Mediating><Mentored Research Scientist Development Award><Mentored Training Award><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Mice><Mice Mammals><Modeling><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Nucleic Acids><Organoids><Oxidative Stress Induction><Oxygen Radicals><Pathway interactions><Patients><Phenotype><Population><Pro-Oxidants><Production><Progenitor Cells><Proliferating><Proteins><Reactive Oxygen Species><Reagent><Research><Research Scientist Development Award><Ribosome Entry Site><Role><Se element><Selenium><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Source><Testing><Therapeutic><Time><Tissue Growth><Tissues><WNT Signaling Pathway><WNT signaling><Work><attenuate><attenuates><biologic><biological signal transduction><bowel><bowel inflammation><cell culture><cell cultures><cell growth><cell type><colitis mouse model><colitis murine model><colitis-induced dysbiosis><complementation><cytokine><defined contribution><detoxification><developmental><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><dyscrasia><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><floxed><floxed allele><gastrointestinal homeostasis><gastrointestinal stem cell><glutathione peroxidase><gut inflammation><gut progenitor><gut stem cell><healing><immune cell infiltrate><improved><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><injuries><intestinal autoinflammation><intestinal epithelium><intestinal homeostasis><intestinal inflammation><intestinal progenitor><intestinal stem cells><intestine disease><intestine disorder><malignancy><mouse colitis><mouse model><murine colitis><murine model><neoplasm/cancer><novel><ontogeny><pathway><prevent><preventing><progenitor biology><progenitor cell biology><progenitor cell function><progenitor cell markers><progenitor cell pool><progenitor cell population><progenitor function><progenitor markers><progenitor pool><progenitor population><progenitor stem cell markers><programs><protective effect><recruit><repair><repaired><selenoenzyme><social role><stem and progenitor biology><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor function><stem cell biology><stem cell biomarkers><stem cell function><stem cell markers><stem cell pool><stem cell population><stem cells><transcriptomics><tumor>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Emily Margaret Mace

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 16/100
Active award
$82,250
FY 2026

Project Title

Lineage tracing origins of human innate lymphoid cells from hematopoietic precursors

Grant Number:

5R03AI187610-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/19/2024

End Date:

10/31/2026

Project Abstract

Project summary Human natural killer (NK) cells are critical for control of viral infection and their importance for human health is underscored by the disease that results from dysregulated NK cell development or function. In the adult, NK cells are continuously generated from stem cells, making th...

Research Terms

<21+ years old><3-D modeling><3D modeling><Address><Adult><Adult Human><Apoptosis><Apoptosis Pathway><Appearance><Bar Codes><Behavior><Blood Cells><Body Tissues><CD34><CD34 gene><Cancers><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Interaction><Cell Lineage><Cell Signaling><Cell surface><Cell-to-Cell Interaction><Cells><Complex><Cytotoxic cell><Data><Development><Disease><Disorder><Embryoid bodies><Generalized Growth><Generations><Genetic><Growth><HPCA1><Health><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Hematopoiesis><Hematopoietic><Hematopoietic Cellular Control Mechanisms><Human><Image><Image Analyses><Image Analysis><Immune><Immunes><Immunity><Immunomodulation><In Vitro><Inducer Cells><Inducer T-Lymphocytes><Inflammation><Intracellular Communication and Signaling><K lymphocyte><Label><Lineage Tracing><Link><Lymphatic cell><Lymphocyte><Lymphocytic><Lymphoid><Lymphoid Cell><Malignant Neoplasms><Malignant Tumor><Maps><Methods><Modern Man><Multipotent Stem Cells><Myelogenous><Myeloid><Myeloid Cells><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><NK Cells><Natural Killer Cells><Peripheral Blood Cell><Phenotype><Play><Precursor NK-Cell><Precursor Natural Killer Cell><Process><Progenitor Cells><Programmed Cell Death><Reporter><Research Resources><Resolution><Resources><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Site><System><Time><Tissue Growth><Tissues><Viral Diseases><Virus Diseases><Visualization><adulthood><barcode><biological signal transduction><blood cell formation><cell behavior><cell fixing><cell imaging><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular behavior><cellular differentiation><cellular imaging><cellular lineage mapping><cellular lineage tracking><developmental><fighting><fluorescence imaging><fluorescent imaging><hemopoietic><human derived pluripotent stem cell><human pluripotent stem cell><iPS><iPSC><iPSCs><image evaluation><image interpretation><imaging><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><live cell image><live cell imaging><live cellular image><live cellular imaging><lymph cell><lymphocyte precursor><lymphocyte progenitor><lymphocyte stem cell><lymphoid precursor><lymphoid progenitors><lymphoid stem cell><malignancy><multipotent progenitor><multipotent progenitor cell><myeloid precursor><myeloid stem and progenitor cell><neoplasm/cancer><novel><ontogeny><peripheral blood><precursor cell><progenitor><recruit><resolutions><restraint><scRNA sequencing><scRNA-seq><self organization><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem cells><three-dimensional modeling><transcriptomics><viral infection><virus infection><virus-induced disease>
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April D Pyle

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 16/100
Active award
$42,500
FY 2026

Project Title

Skeletal Muscle Stem Cells and Regeneration

Grant Number:

1R13AR087323-01

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY This application seeks partial support for the upcoming Society for Muscle Biology (SMB) conference entitled, "Skeletal Muscle Stem Cells in Development, Regeneration, and Adaptations", which will be held July 19-24, 20256 in Victoria, BC, Canada. This will be the 13th edition of thi...

Research Terms

<21+ years old><Adult><Adult Human><Aging><Area><Attention><Autoregulation><Biology><Biomedical Engineering><Body Tissues><Business-Friendly Atmosphere><Canada><Career Choice><Career Path><Cell Communication><Cell Interaction><Cell-to-Cell Interaction><Collaborations><Communication><Communities><Complex><Data><Dedications><Development><Discipline><Disease><Disorder><Educational Achievement><Educational Status><Educational workshop><Engineering><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Evaluation><Fertilization><Fostering><Future><Gene Transcription><Generalized Growth><Genetic Transcription><Geography><Goals><Growth><Health><History><Homeostasis><Hypertrophy><Injections><International><Investigators><Mentors><Modeling><Molecular><Muscle><Muscle Development><Muscle Disease><Muscle Disorders><Muscle Tissue><Muscle function><Muscle satellite cell><Muscular Development><Muscular Diseases><Myoneural Junction><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Natural regeneration><Nervous System><Neurologic Body System><Neurologic Organ System><Neuromuscular Junction><Organoids><Participant><Physiologic><Physiological><Physiological Homeostasis><Policies><Productivity><Progenitor Cells><RNA Expression><Recording of previous events><Regeneration><Regenerative capacity><Regulation><Research><Research Personnel><Researchers><Science><Scientist><Skeletal Muscle><Slide><Societies><Structure><Survey Instrument><Surveys><Therapeutic><Therapeutic Intervention><Tissue Growth><Tissues><Training><Transcription><Transcriptional Control><Transcriptional Regulation><Translating><Voluntary Muscle><Work><Workshop><adulthood><bio-engineered><bio-engineers><bioengineering><biological engineering><bone><business-friendly environment><career><career aspiration><career development><career fair><career interest><career networking><career pathway><career track><cell type><collaborative atmosphere><collaborative environment><conference><convention><developmental><disease model><disorder model><educational level><epigenetic regulation><epigenetically><fertilizations><histories><innovate><innovation><innovative><interactive atmosphere><interactive environment><interdisciplinary atmosphere><interdisciplinary environment><interest><intervention therapy><meeting><meetings><multidisciplinary><muscle engineering><muscle fiber repair><muscle progenitor><muscle progenitor cell><muscle regeneration><muscle repair><muscle stem cell><muscle tissue repair><muscular><muscular disorder><muscular repair><new technology><novel><novel technologies><ontogeny><peer-group atmosphere><peer-group environment><posters><professional networking><progenitor biology><progenitor cell based therapy><progenitor cell biology><progenitor cell niche><progenitor cell therapy><progenitor cell treatment><progenitor niche><progenitor therapy><progenitor treatment><programs><regenerate><regeneration ability><regeneration capacity><repair><repaired><satellite cell><senescence><senescent><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><speed networking><stem and progenitor biology><stem and progenitor cell niche><stem and progenitor cell therapy><stem cell based therapy><stem cell biology><stem cell mediated therapy><stem cell niche><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><summit><symposia><symposium><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic development><tool><training achievement><training level><training status><unpublished works><virtual>
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TERRY L. SHEPPARD

KEYSTONE SYMPOSIA, SILVERTHORNE, CO

Exploratory lead · 16/100
Active award
$18,100
FY 2026

Project Title

iPSCs: Progress, Opportunities, and Challenges

Grant Number:

1R13TR006099-01

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/20/2026

End Date:

12/31/2026

Project Abstract

Abstract Support is requested for a Keystone Symposia conference entitled “iPSCs: Progress, Opportunities, and Challenges,” organized by Drs. Shinya Yamanaka, Yanhong Shi and Yasushi Kajii, with scientific programming input from Keystone Symposia. The meeting will take place January 26–29, 2026 at t...

Research Terms

<3-D><3-Dimensional><3D><AI technology><Academia><Acceleration><Achievement><Achievement Attainment><Address><Anniversary><Area><Career Choice><Career Path><Cell Therapy><Clinical><Clinical Trials><Collaborations><Communities><Development><Drug usage><Drugs><Embryology><Emergent Technologies><Emerging Technologies><Ensure><Future><Goals><Hearing><Industrialization><Industry><International><Investigators><Japan><Knowledge><Learning><Machine Learning><Medical><Medication><Organoids><Outcome><Pharmaceutical Preparations><Progenitor Cells><R-Series Research Projects><R01 Mechanism><R01 Program><Regenerative Medicine><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Scientist><Senior Scientist><System><Testing><Therapeutic><Translational Research><Translational Science><Work><artificial intelligence technology><career><career aspiration><career development><career interest><career pathway><career track><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chip model><chip system><clinical practice><conference><convention><design><designing><develop therapy><developmental><disease model><disorder model><drug discovery><drug use><drug/agent><experience><hiPSC><human disease><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSC technology><iPSCs><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell technology><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><innovative technologies><insight><intervention development><machine based learning><meeting><meetings><multidisciplinary><new drug treatments><new drugs><new pharmacological therapeutic><new technology><new therapeutics><new therapy><next generation><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel technologies><novel therapeutics><novel therapy><on a chip><on chip><organ chip><organ on a chip><organ on chip><posters><progenitor biology><progenitor cell based therapy><progenitor cell biology><progenitor cell therapy><progenitor cell treatment><progenitor therapy><progenitor treatment><stem and progenitor biology><stem and progenitor cell therapy><stem cell based therapy><stem cell biology><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells><summit><symposia><symposium><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic development><therapy development><three dimensional><translation research><translational investigation><treatment development>
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Milos Marinkovic

RLR VA MEDICAL CENTER, INDIANAPOLIS, IN

Exploratory lead · 16/100
Active award
$0
FY 2026

Project Title

Role of Cyr61/CCN1 in Mesenchymal Stem Cell Niche and Aging Bone

Grant Number:

5IK2BX005694-05

Activity Code:

IK2

Mechanism:

Other

Agency:

VA

Start Date:

1/1/2022

End Date:

12/31/2026

Project Abstract

Aging-related skeletal degeneration is associated with changes in bone microarchitecture, loss of bone mineral density (BMD), increased susceptibility to fracture, and delayed bone healing. A key factor in these degenerative changes is the formation of osteoprogenitors (i.e. mesenchymal stem cells [...

Research Terms

<Address><Adenoviridae><Adenoviruses><Age><Aging><Animals><BM Stem Cell><BM derived progenitor><BM progenitor><BM- derived Stem Cells><BMP-2><BMP-2A><BMP2><BMP2 gene><BMP2A Gene><Binding><Bioinformatics><Biology of Aging><Body Tissues><Bone Density><Bone Formation><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Marrow Stem Cell><Bone Marrow progenitor><Bone Matrix><Bone Mineral Density><Bone Morphogenetic Protein 2 Gene><Bone Morphogenetic Protein 2A Gene><Bone structure><Cell Body><Cell-Extracellular Matrix><Cells><Cues><Data><Dephosphorylation><Dose><ECM><Exhibits><Experimental Designs><Extracellular Matrix><Fifth lumbar vertebra><Fracture><Fracture Healing><Gene Transfer><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Growth Agents><Growth Factor><Growth Substances><Harvest><Healing abnormal><Healing delayed><Health><Health Care><Histology><IGF-1><IGF-I><IGF-I-SmC><Immunoblotting><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impaired healing><Implant><In Vitro><Injury><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Investigators><KO mice><Knock-out Mice><Knockout Mice><Knowledge><L5 Vertebra><Laboratories><Lateral><Lead><Maintenance><Measures><Mentors><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Methods><Mice><Mice Mammals><Molecular Interaction><Morbidity><Murine><Mus><Natural regeneration><Null Mouse><Operative Procedures><Operative Surgical Procedures><Osteoblasts><Osteogenesis><Osteoporosis><Pb element><Phenotype><Population><Predisposition><Production><Progenitor Cells><Protein Dephosphorylation><Proteins><Proteins Growth Factors><Proteome><Proteomics><Radiography><Recombinant DNA Technology><Regeneration><Reporting><Research><Research Personnel><Researchers><Risk><Roentgenography><Role><Short interfering RNA><Small Interfering RNA><Somatomedin C><Spinal Fractures><Spinal Fusion><Spondylosyndeses><Stem Cell like><Surgical><Surgical Interventions><Surgical Procedure><Susceptibility><System><Testing><Time><Tissues><Veterans><Western Blotting><Western Immunoblotting><Woman><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age related alterations><age related changes><age related pathways><age reversal><age specific alterations><age specific changes><aged mice><aged mouse><ages><aging associated><aging associated alterations><aging associated changes><aging associated disease><aging associated disorders><aging associated mechanism><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging mechanism><aging pathway><aging related><aging related alterations><aging related changes><aging related disease><aging related disorders><aging related mechanism><aging related pathways><aging reversal><aging specific alterations><aging specific changes><alleviate age related><alleviate aging><alterations with age><ameliorating aging><biological mechanism of age><biological pathways of age><bone><bone fracture><bone fracture healing><bone fracture repair><bone healing><bone loss><bone marrow derived progenitor><bone marrow derived stem cells><bone marrow stromal cell><bone marrow stromal stem cell><bone mass><bone morphogenetic protein 2><bone repair><bone tissue formation><bone wound healing><career development><cell behavior><cellular behavior><changes with age><co-morbid><co-morbidity><collagen scaffold><comorbidity><counter age related><counter aging><counteract age related><counteract aging><debilitating pain><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><elderly mice><fracture repair><genetically engineered><heavy metal Pb><heavy metal lead><implantation><improved><in vivo Model><injuries><innovate><innovation><innovative><knock-down><knockdown><mechanism regulating aging><mechanisms involved in aging><men><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><old mice><osseous wound healing><osteoblast cell differentiation><osteoblast differentiation><osteoblast progenitor><osteoblast stem cell><osteoblastic differentiation><osteogenic><osteogenic progenitor><osteogenic stem cell><osteoprogenitor><osteoprogenitor cell><pathway involved in aging><progenitor Cell growth><progenitor capacity><progenitor cell like><progenitor cell niche><progenitor growth><progenitor niche><progenitor-like><protein blotting><radiological imaging><recombinant human bone morphogenetic protein-2><regenerate><regenerative><response><reverse age><reverse aging><reverse aging effects><reversible aging><rhBMP-2><siRNA><side effect><skeletal><skeletal structure><skills><social role><spine fracture><stem and progenitor cell niche><stem cell characteristics><stem cell growth><stem cell niche><stem cells><stem-like><stemness><surgery><tissue wound><tomography><translational opportunities><translational potential><vertebral fracture><wound><wounding><wounds>
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Alexander Neuwelt

VA VETERANS ADMINISTRATION HOSPITAL, RICHMOND, VA

Exploratory lead · 10/100
Active award
$0
FY 2026

Project Title

High dose acetaminophen with n-acetylcysteine rescue as a novel STAT3 inhibitor with anti-cancer stem cell properties

Grant Number:

5IK2BX004914-05

Activity Code:

IK2

Mechanism:

Other

Agency:

VA

Start Date:

10/1/2021

End Date:

9/30/2026

Project Abstract

High dose acetaminophen (AAP) with delayed n-acetylcysteine (NAC) rescue has shown promise in early phase clinical trials, inducing disease shrinkage in 8/14 and an objective response in 3/14 assessable patients with diverse tumor types. However, the mechanism of anti-tumor activity of high dose AAP...

Research Terms

<APAP><APRF protein><Acetamidophenol><Acetaminophen><Acetominophen><Acetylcysteine><Acetylin><Acute-Phase Response Factor><Airbron><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antidotes><Antimorphic mutation><Antinociceptive Agents><Antinociceptive Drugs><Assay><Award><Binding><Bioassay><Biological Assay><Broncholysin><Brunac><CDDP><Cancer Model><Cancer Patient><Cancer Relapse><CancerModel><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chemoresistance><Cis-diammine-dichloroplatinum><Cis-diamminedichloridoplatinum><Cis-diamminedichloro Platinum (II)><Cis-dichloroammine Platinum (II)><Cis-platinous Diamine Dichloride><Cis-platinum II><Cis-platinum II Diamine Dichloride><Cisplatin><Cisplatina><Cisplatinum><Clinical><Clinical Research><Clinical Study><Collaborations><Computer software><Cysplatyna><Data><Dedications><Dichlorodiammineplatinum><Disease><Disorder><Doctor of Philosophy><Dominant Negative><Dominant-Negative Mutant><Dominant-Negative Mutation><Dose><Drug Targeting><Drug usage><Drugs><EGF Receptor><EGFR><ERBB Protein><Education><Educational aspects><Enrollment><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><Exhibits><Fabrol><Fluatox><Fluimucetin><Fluimucil><Fluprowit><Foundations><Free Radicals><Funding><Gene Transcription><Genes><Genetic Transcription><Glutathione><Goals><H-bond><HER1><Head><Hepatoblastoma><Hepatotoxic effect><Hepatotoxicity><Heterograft><Heterologous Transplantation><Human><Hydrogen Bonding><Hydroxyacetanilide><IL6-response factor><In Vitro><In complete remission><Injury><Intracellular Communication and Signaling><Invaded><Investigators><K-Awards><K-Series Research Career Programs><Knock-out><Knockout><Knowledge><LIF-response factor><Laboratory Research><Length><Liver><Liver Toxicity><Maintenance><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mediating><Medication><Medicinal Chemistry><Mentors><Mercapturic Acid><Methods><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Molecular><Molecular Interaction><Muco Sanigen><Mucocedyl><Mucolator><Mucolyticum><Mucomyst><Mucosolvin><Mucret><Murine><Mus><N-Acetylcysteine><NAC Zambon><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Natural regeneration><Neo-Fluimucil><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><Overdose><PDX model><Paracetamol><Parvolex><Patient Selection><Patient derived xenograft><Patients><Pediatric Embryonal Hepatoma><Pediatric Hepatoblastoma><Peyrone's Chloride><Peyrone's Salt><Ph.D.><PhD><Pharmaceutic Chemistry><Pharmaceutical Chemistry><Pharmaceutical Preparations><Phenotype><Phosphorylation><Physicians><Physiology><Platinum Diamminodichloride><Play><Population><Process><Prognosis><Proliferating><Property><Protein Phosphorylation><Proteins><Pulmonary Cancer><Pulmonary malignant Neoplasm><RNA Expression><Regeneration><Regulation><Research><Research Career Program><Research Personnel><Research Resources><Researchers><Resistance><Resources><Respaire><Role><SH2 Domains><STAT3><STAT3 gene><Scientist><Series><Signal Transducer and Activator of Transcription 3><Signal Transduction><Signal Transduction Systems><Signaling><Site-Directed Mutagenesis><Site-Specific Mutagenesis><Software><Stat3 protein><TGF-alpha Receptor><Targeted DNA Modification><Targeted Modification><Testing><Theriacs><Time><Tixair><Toxic effect><Toxic effect on liver cells><Toxicities><Transcription><Transfection><Transforming Growth Factor alpha Receptor><Tumor Cell><Tumorigenicity><Universities><Urogastrone Receptor><Virginia><Work><Xenograft><Xenograft procedure><Xenotransplantation><anti-cancer><anti-tumor effect><anticancer activity><antitumor effect><biological signal transduction><c-erbB-1><c-erbB-1 Protein><cancer cell><cancer microenvironment><cancer progenitor><cancer progenitor cells><cancer stem cell><cancer stem like cell><career><chemoresistant><chemotherapy><chemotherapy resistance><chemotherapy resistant><cis dichlorodiammineplatinum><cis platinum compound><cis-Diaminedichloroplatinum><cis-Diamminedichloroplatinum><cis-Diamminedichloroplatinum(II)><cis-Dichlorodiammineplatinum(II)><cis-Platinum><complete response><conference><convention><driver lesion><driver mutation><drug use><drug/agent><early clinical trial><early phase clinical trial><enroll><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><experience><experiment><experimental research><experimental study><experiments><gamma-L-Glu-L-Cys-Gly><gamma-L-Glutamyl-L-Cysteinylglycine><hepatic body system><hepatic organ system><hepatic toxicity><hepatoxicity><in silico><in vivo><inhibitor><injuries><insight><lung cancer><lung cancer cell><malignancy><malignant progenitor><malignant stem cell><mitochondrial><neoplasm/cancer><neoplastic cell><novel><oncogenic progenitor><oncogenic stem cells><pain killer><pain medication><pain reliever><painkiller><patient derived xenograft model><pre-clinical><preclinical><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><progenitor Cell growth><progenitor biology><progenitor cell biology><progenitor cell markers><progenitor cell pool><progenitor cell population><progenitor growth><progenitor like cancer cell><progenitor markers><progenitor pool><progenitor population><progenitor stem cell markers><proto-oncogene protein c-erbB-1><regenerate><resistant><response><self-renew><self-renewal><skills><social role><spheroids><src Homology Region 2 Domain><stem and progenitor biology><stem and progenitor cell population><stem cell biology><stem cell biomarkers><stem cell growth><stem cell markers><stem cell pool><stem cell population><stem like cancer cell><summit><symposia><symposium><synergism><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tumor><tumor growth><tumor microenvironment><vector><xeno-transplant><xeno-transplantation>
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Katherine Elizabeth Hekman

VETERANS ADMIN PALO ALTO HEALTH CARE SYS, PALO ALTO, CA

Exploratory lead · 10/100
Active award
$0
FY 2026

Project Title

Improving Induced Pluripotent Stem Cell-Derived Endothelial Cells as Therapy for Peripheral Arterial Disease

Grant Number:

5IK2BX006275-02

Activity Code:

IK2

Mechanism:

Other

Agency:

VA

Start Date:

10/1/2024

End Date:

3/31/2030

Project Abstract

Veterans experience peripheral arterial disease (PAD) onset at an earlier age than their non-Veteran counterparts and are at increased risk of experiencing adverse outcomes from this disease. Advanced PAD is a significant cause of morbidity, including major amputation. While endovascular and surgica...

Research Terms

<2 year old><2 years of age><Acceleration><Acute><Address><Adverse Experience><Adverse event><Age><Alternative Therapies><Alternative intervention><Amputation><Amputees><Animal Model><Animal Models and Related Studies><Aorta><Beds><Blood Platelets><Blood Vessels><Body Tissues><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Survival><Cell Therapy><Cell Viability><Cells><Clinic><Clinical><Clinical Trials><Combined Modality Therapy><Culture Media><Data><Disease Outcome><Drug Therapy><Dysfunction><Endothelial Cells><Extremities><Female><Fibrin><Foundations><Functional disorder><Funding><Genus Hippocampus><Ginsenosides><Goals><Harvest><Hindlimb><Human><Hydrogels><Hypoxia><Hypoxic><Impairment><Implant><In Vitro><Intramuscular><Ischemia><Limb Salvage><Limb structure><Limbs><Lysosomes><Mammalia><Mammals><Marrow platelet><Measures><Mediating><Mentors><Mice><Mice Mammals><Mitochondria><Modality><Modeling><Modern Man><Morbidity><Multimodal Therapy><Multimodal Treatment><Murine><Mus><Muscle Disease><Muscle Disorders><Muscular Diseases><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Natural regeneration><Network Analysis><Non-Trunk><Nutrient><Nutritional Support><Onset of illness><Operative Procedures><Operative Surgical Procedures><Oxygen Deficiency><Pain Control><Pain Therapy><Pain management><Panaxosides><Pathway Analysis><Pathway interactions><Patients><Performance><Perfusion><Peripheral arterial disease><Pharmacological Treatment><Pharmacotherapy><Physiologic><Physiological><Physiopathology><Platelets><Progenitor Cells><Proteins><Recycling><Regeneration><Regenerative capacity><Rejuvenation><Reperfusion Therapy><Research Resources><Resources><Risk><Sanchinosides><Scientist><Seahorse><Source><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Techniques><Technology><Testing><Therapeutic><Thrombocytes><Tissues><Training><VEGF><VEGFs><Vascular Endothelial Growth Factors><Vascular regeneration><Veterans><Wood><Wood material><Work><adult youth><adverse consequence><adverse outcome><age 2><age 2 years><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged 2 years><aged mice><aged mouse><aged two years><ages><aging associated disease><aging associated disorders><aging related disease><aging related disorders><angiogenesis><career><cell based intervention><cell mediated intervention><cell mediated therapies><cell sorting><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><clinical relevance><clinically relevant><combination therapy><combined modality treatment><combined treatment><disability><disabled><disease associated with aging><disease of aging><disease onset><disorder of aging><disorder onset><disorders associated with aging><disorders related to aging><drug intervention><drug treatment><early onset><elderly mice><experience><foot><functional improvement><growth media><iPS><iPS biology><iPSC><iPSC biology><iPSCs><implantation><improve function><improved><improved functional outcomes><in vitro Model><in vivo regeneration><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell biology><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><ischemic limb><limb ischemia><limb loss><lost limb><male><mitochondrial><mitochondrial dysfunction><mitochondrial metabolism><model of animal><mortality><mouse model><multi-modal therapy><multi-modal treatment><murine model><muscular disorder><neovascularization><novel><nutritional care><nutritional therapy><old mice><pain intervention><pain treatment><palliation><pathophysiology><pathway><peripheral artery disease><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><prevent><preventing><regenerate><regeneration ability><regeneration based therapy><regeneration capacity><regeneration function><regeneration therapy><regenerative approach><regenerative function><regenerative functionality><regenerative strategy><regenerative technique><regenerative therapeutics><regenerative therapy><reperfusion><revascularization><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><stem cells><surgery><synergism><two year old><two years of age><vascular><young adult><young adult age><young adulthood><♀><♂>
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Anoop Kumar

JESSE BROWN VA MEDICAL CENTER, CHICAGO, IL

Exploratory lead · 10/100
Active award
$0
FY 2026

Project Title

A Novel Role of Apical Chloride Transporter (DRA) in Mucosal Tissue Repair

Grant Number:

5I01BX006626-02

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2024

End Date:

9/30/2028

Project Abstract

Inflammatory bowel diseases (IBDs) comprising of Crohn’s disease (CD) and ulcerative colitis (UC), are characterized by chronic inflammation of the GI tract with increasing incidence and prevalence worldwide. Remarkably, over 66,000 US veterans suffer from IBD and exhibit symptoms such as diarrhea, ...

Research Terms

<Abdominal Pain><Acute><Affect><Age><Alimentary Canal><Apical><Beta Cadherin-Associated Protein><Beta-1 Catenin><Bioenergetics><Body Tissues><CUL-2><Cell Communication and Signaling><Cell Cycle><Cell Division Cycle><Cell Lineage><Cell Signaling><Cell-Extracellular Matrix><Chlorides><Chronic><Chronic Disease><Chronic Illness><Colitis><Colon><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><Cytokines and Inflammatory Response><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Data><Diarrhea><Dietary Fats><Digestive Tract><Disease><Disease remission><Disorder><Down-Regulated in Adenoma><Down-Regulation><DownRegulated in Adenoma><ECM><Epithelium><Event><Exhibits><Extracellular Matrix><Ferricytochrome c><Ferrocytochrome c><Flare><GI Tract><GI microbiome><GWA study><GWAS><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Expression><General Population><General Public><Germ-Free><Granulomatous Enteritis><Gut Epithelial Permeability><Gut Hyperpermeability><Gut permeability><HG38><Health Care><Human><Impaired tissue repair><Impaired wound healing><Impairment><Incidence><Inflammation><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Inflammatory Response Pathway><Injury><Intestinal><Intestinal Epithelial Permeability><Intestinal Hyperpermeability><Intestinal permeability><Intestines><Intracellular Communication and Signaling><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><LGR5><LGR5 gene><MOPA><Maintenance><Mice><Mice Mammals><Microscopy><Mission><Mitochondria><Modality><Modeling><Modern Man><Molecular><Morbidity><Morphology><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Natural regeneration><Null Mouse><Outcome Study><Oxidative Stress><PRO2286><Pathogenesis><Pathway interactions><Patients><Permeability><Persons><Play><Population><Predisposition gene><Prevalence><Progenitor Cells><Protein C><RNA Seq><RNA sequencing><RNAseq><Recovery><Regeneration><Relapse><Remission><Research><Resting progenitor><Role><SLC26A3><SLC26A3 gene><Signal Transduction><Signal Transduction Systems><Signaling><Susceptibility Gene><Symptoms><Testing><Therapeutic><Time><Tissues><Transgenic Mice><Ulcerated Colitis><Ulcerative Colitis><United States><Upregulation><Veterans><Wild Type Mouse><Wound Repair><abnormal tissue repair><ages><alimentary tract><beta cat><beta catenin><biological signal transduction><bowel><bowel inflammation><chronic disorder><clinical remission><colitis-induced dysbiosis><cytochrome c><delayed wound healing><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><dietary lipid><digestive canal><digestive tract microbiome><dormant stem cell><dysbacteriosis><dysbiosis><dysbiotic><eleocolitis><enteric microbiome><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><gastrointestinal microbiome><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><gut inflammation><gut microbiome><gut-associated microbiome><healing><health care burden><improved><inactive stem cell><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><injuries><innovate><innovation><innovative><intestinal autoinflammation><intestinal biome><intestinal epithelium><intestinal inflammation><intestinal microbiome><knock-down><knockdown><latent progenitor><latent stem cell><lysophosphatidic acid><microbial><microbial imbalance><mitochondrial><mitochondrial dysfunction><monooleylphosphatidate><monooleylphosphatidic acid><nanostring><novel><overexpress><overexpression><pathway><predisposing gene><prevent><preventing><progenitor cell function><progenitor cell markers><progenitor cell niche><progenitor cell pool><progenitor cell population><progenitor function><progenitor markers><progenitor niche><progenitor pool><progenitor population><progenitor stem cell markers><protein expression><quiescent progenitor><quiescent stem cells><regenerate><regional enteritis><repair><repaired><resting stem cell><restoration><social role><stem and progenitor cell function><stem and progenitor cell niche><stem and progenitor cell population><stem and progenitor function><stem cell biomarkers><stem cell function><stem cell markers><stem cell niche><stem cell pool><stem cell population><stem cell quiescence><stem cells><susceptibility allele><susceptibility locus><susceptibility variant><therapeutic target><tissue repair><transcriptome sequencing><transcriptomic sequencing><whole genome association analysis><whole genome association study><wildtype mouse><wound healing><wound recovery><wound resolution><β-catenin>
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Nu Zhang

SOUTH TEXAS VETERANS HEALTH CARE SYSTEM, SAN ANTONIO, TX

Exploratory lead · 10/100
Active award
$0
FY 2026

Project Title

Targeting lymphoid tissue residency to boost tumor immunotherapies

Grant Number:

5I01BX005955-04

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2022

End Date:

9/30/2026

Project Abstract

Several current tumor immunotherapies (e.g., PD-1/PD-L1 blockade and tumor vaccine) are designed to boost endogenous tumor-specific T cell responses. To improve the efficacy of current immunotherapies and benefit more cancer patients, it is urgent to advance our knowledge about the cellular and mole...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><AH Receptors><Adjuvant><Adopted><Affinity><Antigens><Antineoplastic Vaccine><Area><Aryl Hydrocarbon Receptor><Basal Transcription Factor><Basal transcription factor genes><Biology><Body Tissues><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cancer Patient><Cancer Vaccines><Cancers><Cell Body><Cell Communication and Signaling><Cell Locomotion><Cell Migration><Cell Movement><Cell Signaling><Cells><Cellular Migration><Cellular Motility><Communication><Defect><Development><Dioxin Receptors><Exhibits><Future><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic><Genetic Transcription><Harvest><Health><Health Care Systems><Immune><Immune Targeting><Immune mediated therapy><Immune response><Immune system><Immunes><Immunologically Directed Therapy><Immunotherapy><Intracellular Communication and Signaling><Investigation><Knowledge><Lymph Node Tissue><Lymphatic Tissue><Lymphoid><Lymphoid Tissue><Malignant Neoplasms><Malignant Tumor><Mediating><Mice><Mice Mammals><Modeling><Molecular><Molecular Target><Murine><Mus><Names><Neoplasm Vaccines><Nuclear Translocator><PD-1/PD-L1><PD-1/PDL1><PD-L1 blockade><PD1-PD-L1><PD1/PD-L1><PD1/PDL1><PDL1 blockade><Patients><Pattern><Phenotype><Polyaromatic Hydrocarbon Receptors><Population><Progenitor Cells><RNA Expression><Receptor Protein><Research><Residencies><Role><Signal Transduction><Signal Transduction Systems><Signaling><Site><Stem Cell like><System><T cell differentiation><T cell response><T memory cell><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T8 Cells><T8 Lymphocytes><TCDD Receptors><Testing><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transforming Growth Factors><Translating><Tumor Antigens><Tumor Growth Factors><Tumor Immunity><Tumor Vaccines><Tumor-Associated Antigen><Veterans><acute infection><anti-PD-L1 blockade><anti-tumor immune therapy><anti-tumor immunity><anti-tumor immunotherapy><anti-tumor vaccine><antitumor immunity><biological signal transduction><cancer antigens><cancer immunity><cancer survival><cancer vaccination><cell motility><check point blockade><checkpoint blockade><design><designing><developmental><draining lymph node><drug candidate><experience><experiment><experimental research><experimental study><experiments><host response><immune check point blockade><immune checkpoint blockade><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunoresponse><improved><improved outcome><inhibitor><insight><irradiation><malignancy><memory T lymphocyte><migration><name><named><naming><neoplasm immunotherapy><neoplasm/cancer><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathogen><pharmacologic><prevent><preventing><progenitor biology><progenitor capacity><progenitor cell biology><progenitor cell differentiation><progenitor cell like><progenitor differentiation><progenitor-like><programs><rational design><receptor><regional lymph node><resident memory T cell><response><social role><spatial and temporal><spatial temporal><spatiotemporal><stem><stem and progenitor biology><stem and progenitor differentiation><stem cell biology><stem cell characteristics><stem cell differentiation><stem cells><stem-like><stemness><synergism><thymus derived lymphocyte><tissue resident memory T cell><transcription factor><transforming growth factors Animal growth regulators><translational opportunities><translational potential><tumor><tumor immune therapy><tumor immunotherapy><tumor vaccination><tumor-specific antigen><vaccine for cancer>
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LUKE Packard BREWSTER

CINCINNATI VA MEDICAL CENTER RESEARCH, CINCINNATI, OH

Exploratory lead · 10/100
Active award
$0
FY 2026

Project Title

Molecular Repair of Diabetic Mesenchymal Stem Cells (dMSC) for Peripheral Arterial Disease

Grant Number:

5I01BX004707-07

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

1/1/2020

End Date:

9/30/2028

Project Abstract

Background and Innovation: Diabetes and ischemia lead to loss of neuromotor connections resulting in disability. Diabetic Veterans with PAD have significant therapeutic needs that are often incompletely addressed due to limitations in our understanding and therapeutic options. Functional recovery of...

Research Terms

<ATAC sequencing><ATAC-seq><ATACseq><Abnormal gait><Acceleration><Activities of Daily Living><Activities of everyday life><Address><Affect><Amputation><Animals><Assay for Transposase-Accessible Chromatin using sequencing><Autologous><Blood><Blood Platelets><Blood Reticuloendothelial System><Blood Vessels><Blood capillaries><Body Tissues><Cancers><Cell Aging><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Function><Cell Interaction><Cell Physiology><Cell Process><Cell Senescence><Cell Signaling><Cell Therapy><Cell-to-Cell Interaction><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Chromatin><Chronic><Clinical><Contralateral><Defect><Development><Diabetes Mellitus><Endothelial Cells><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Extremities><Functional Regeneration><Functional impairment><Funding><Gait abnormality><Gait disorder><Gait disturbances><Gait dysfunction><Gait impairment><Gene Transcription><Genetic Transcription><Goals><Health Care><Hindlimb><Human><Immune><Immune Modulation Therapy><Immune response><Immunes><Immunoblotting><Impairment><In Vitro><Incidence><Inflammation><Inflammatory><Injury><Innate Immune System><Intracellular Communication and Signaling><Ischemia><Laser Electromagnetic><Laser Radiation><Lasers><Lead><Leg><Limb structure><Limbs><Macrophage><Malignant Neoplasms><Malignant Tumor><Marrow platelet><Mediator><Medical><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Motor End-Plate><Motor Endplate><Murine><Mus><Muscle><Muscle Atrophy><Muscle Denervation><Muscle Disease><Muscle Disorders><Muscle Fibers><Muscle Tissue><Muscle denervation procedure><Muscular Atrophy><Muscular Diseases><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Myotubes><Mφ><Natural regeneration><Non-Trunk><Obesity><PBSC><Pain><Painful><Pathology><Pathway interactions><Patients><Pb element><Performance><Perfusion><Peripheral Blood Stem Cell><Peripheral Stem Cells><Peripheral arterial disease><Peripheral blood progenitor><Platelets><Process><Publications><RNA Expression><Recovery of Function><Regeneration><Regenerative capacity><Rejuvenation><Replicative Senescence><Research><Resolution><Rhabdomyocyte><Role><Running><Scientific Publication><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Speed><Staining method><Stains><Subcellular Process><Synapses><Synaptic><Testing><Therapeutic><Thrombocytes><Time><Tissues><Transcription><Translations><Vascular blood supply><Vascular regeneration><Veterans><Voluntary Muscle><Walking><Walking impairment><Western Blotting><Western Immunoblotting><Work><adiposity><age associated><age correlated><age dependent><age linked><age related><age specific><angiogen><assault><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><axon regeneration><axonal regeneration><biological signal transduction><blood supply><capillary><cell based intervention><cell mediated intervention><cell mediated therapies><cell regeneration><cell-based therapeutic><cell-based therapy><cellular regeneration><cellular therapeutic><cellular therapy><clinical translation><clinically translatable><corpulence><daily living function><daily living functionality><density><developmental><diabetes><diabetic><diabetic patient><disability><empowerment><epigenetic regulation><epigenetically><functional ability><functional capacity><functional recovery><functional restoration><heavy metal Pb><heavy metal lead><host response><immune modulatory therapies><immune modulatory treatment><immune regulation therapy><immune regulation treatment><immune regulatory therapy><immune system response><immune-modulation treatment><immunomodulation therapy><immunomodulation treatment><immunomodulator therapies><immunomodulator treatment><immunomodulator-based therapies><immunomodulatory biologics><immunomodulatory therapies><immunomodulatory treatment><immunoregulatory therapy><immunoregulatory treatment><immunoresponse><improved><in vivo><in vivo Model><inflammatory environment><inflammatory milieu><injured><injuries><innervation><innovate><innovation><innovative><malignancy><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><military veteran><muscle breakdown><muscle degradation><muscle deterioration><muscle loss><muscle regeneration><muscle wasting><muscular><muscular disorder><neoplasm/cancer><nerve supply><neuromuscular><neuron regeneration><neuronal regeneration><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-diabetic><nondiabetic><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><peripheral artery disease><peripheral nerve regeneration><progenitor cell based therapy><progenitor cell therapy><progenitor cell treatment><progenitor therapy><progenitor treatment><protein blotting><regenerate><regeneration ability><regeneration based therapy><regeneration capacity><regeneration therapy><regenerative><regenerative cell><regenerative therapeutics><regenerative therapy><reinnervate><reinnervation><repair><repaired><replicative aging><resolutions><response><restore function><restore functionality><restore lost function><social role><stem and progenitor cell therapy><stem cell based therapy><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><success><synapse><therapeutic immunomodulation><therapeutic immunoregulation><translation><translational opportunities><translational potential><vascular><vascular supply><veteran population>
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Hongjun Wang

RALPH H JOHNSON VA MEDICAL CENTER, CHARLESTON, SC

Exploratory lead · 10/100
Active award
$0
FY 2026

Project Title

hAAT-engineered Mesenchymal Stem Cells for the Treatment of Chronic Pain

Grant Number:

5I01BX004536-06

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2019

End Date:

9/30/2028

Project Abstract

One-third of the veterans (~20 million) are suffering from chronic pain. This grant studies chronic pancreatitis (CP)-associated chronic pain in which pain is common and leads to morbidity, poor quality of life, and loss of workdays. Our current VA-funded BLR&D grant is focused on novel stem cell th...

Research Terms

<A1PI><Abdomen><Amphoterin><Amphoterin Gene><Animal Model><Animal Models and Related Studies><Body Tissues><C-KIT Gene><CD117><CD117 Antigens><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Locomotion><Cell Maturation><Cell Migration><Cell Movement><Cell Signaling><Cell Therapy><Cell-to-Cell Interaction><Cells><Cellular Expansion><Cellular Growth><Cellular Migration><Cellular Motility><Chromosomal Protein, Nonhistone, HMG1><Chromosomal Protein, Nonhistone, HMG1 Gene><Chronic><Clinical Trials><Data><Dedications><Development><Disease><Disorder><Dorsal Root Ganglia><Down-Regulation><Dysfunction><Engineering><Evaluation><FM1 Gene Product><Functional disorder><Funding><Goals><Grant><HMG-1><HMG-1 Gene><HMG-1 Protein><HMG1><HMG1 Gene><HMG3><HMG3 Gene><HMGB1><HMGB1 Protein><HMGB1 gene><Health><Health Care><Heparin-Binding Protein p30><High Mobility Group Box Protein 1><High Mobility Group Protein 1><High Mobility Group Protein 1 Gene><High-Mobility Group (Nonhistone Chromosomal) Protein 1><High-Mobility Group (Nonhistone Chromosomal) Protein 1 Gene><High-Mobility Group Box 1><High-Mobility Group Box 1 Gene><Human><Immunofluorescence><Immunofluorescence Immunologic><Infiltration><Inflammation><Inflammatory><Infusion><Infusion procedures><Intracellular Communication and Signaling><Marrow Mast Cell><Mast Cell Growth Factor Receptor><Mediating><Mesenchymal><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Metabolic><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Morbidity><Murine><Mus><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neurocyte><Neuronal Transmission><Neurons><Neuropathy><Nonhistone Chromosomal Protein HGM1><Nonhistone Chromosomal Protein HGM1 Gene><Organoids><Pain><Painful><Painless><Pancreas><Pancreatic><Pathway interactions><Patients><Peripheral><Physiopathology><Play><Population><Proto-Oncogene Protein c-kit><QOL><Quality of life><Rodent Model><Role><SBP-1><SBP-1 Gene><SCF Receptor><SCF Receptor Gene><SCFR><Sampling><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Spinal Ganglia><Staining method><Stains><Stem Cell Factor Receptor><Stem Cell Factor Receptor Gene><Stromal Cells><Sulfoglucuronyl Carbohydrate Binding Protein><Sulfoglucuronyl Carbohydrate Binding Protein Gene><Sulfonic Acids><TLR protein><TNBS colitis><TNBS mice><TNBS model><TNBS mouse model><TNBS-induced colitis><Testing><Therapeutic><Tissue Basophils><Tissues><Toll-Like Receptor Family Gene><Toll-like receptors><Translations><Veterans><Wild Type Mouse><Work><alpha 1 Antiprotease><alpha 1-Antiproteinase><alpha 1-Antitrypsin><alpha 1-Antitrypsin Trypsin Inhibitor><alpha 1-Protease Inhibitor><alpha 1-Proteinase Inhibitor><axon signaling><axon-glial signaling><axonal signaling><biological signal transduction><c kit><c-kit Protein><c-kit Receptor><cell based intervention><cell growth><cell mediated intervention><cell mediated therapies><cell motility><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><central sensitization><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><chronic pancreatitis><developmental><dorsal root ganglion><experiment><experimental research><experimental study><experiments><glia signaling><glial signaling><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infusions><insight><kit Proto-Oncogene Protein><mast cell><mastocyte><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><migration><military veteran><model of animal><nerve signaling><neural signaling><neuronal><neuronal signaling><neuropathic><neuropathic pain><neurotransmission><new approaches><nitrobenzene><non-painful><nonpainful><not painful><novel><novel approaches><novel strategies><novel strategy><overexpress><overexpression><p145(c-kit)><p145c-kit><pain reduction><pain relief><painful neuropathy><pathophysiology><pathway><peripheral pain><pre-clinical><preclinical><prevent><preventing><progenitor cell based therapy><progenitor cell therapy><progenitor cell treatment><progenitor therapy><progenitor treatment><recurrent pancreatitis><reduce pain><relieve pain><response><social role><stem><stem and progenitor cell therapy><stem cell based therapy><stem cell mediated therapy><stem cell organoids><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cell-derived organoids><translation><translation to humans><translational opportunities><translational potential><treat chronic pain><trinitrobenzene sulfonic acid colitis><trinitrobenzene sulfonic acid induced colitis><trinitrobenzene sulfonic acid induced mouse model><trinitrobenzene sulfonic acid model><trinitrobenzene sulfonic acid mouse model><veteran population><wildtype mouse><α1-Antitrypsin><α1-Proteinase Inhibitor>
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Xiaosi Han

BIRMINGHAM VA MEDICAL CENTER, BIRMINGHAM, AL

Exploratory lead · 10/100
Active award
$0
FY 2026

Project Title

Modeling IDH Mutant Gliomas by Genetic Engineering of Brain Organoid

Grant Number:

5I01BX006107-03

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2023

End Date:

9/30/2027

Project Abstract

Project Summary/Abstract Gliomas are incurable and are the number two cause for tumor mortality in adult under 40 years old. Monoallelic mutations of IDH1 and IDH2, which encode isocitrate dehydrogenases (IDH) that convert isocitrate into α-ketoglutarate (αKG), have been detected in 80% of low grade...

Research Terms

<2-ketoglutarate><2-oxoglutarate><21+ years old><ATRX><ATRX gene><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Antioncogene Protein p53><Architecture><Astrocytes><Astrocytus><Astroglia><Brain><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><Cancer Cause><Cancer Etiology><Cell Body><Cell Survival><Cell Viability><Cells><Cellular Tumor Antigen P53><Cessation of life><DNA><DNA Alteration><DNA Sequence Alteration><DNA mutation><Death><Deoxyribonucleic Acid><Diagnosis><Disease><Disorder><Dissection><Encephalon><Engineering / Architecture><Ensure><Enzyme Gene><Enzymes><Event><Family><Gene Expression><Generalized Growth><Genes><Genetic><Genetic Alteration><Genetic Change><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic defect><Genetic mutation><Genomics><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioblastoma><Glioma><Gliomagenesis><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><Growth><Heterograft><Heterologous Transplantation><Human><Hydroxylases><In Vitro><Inhibition of Cell Proliferation><Intervention><Investments><Isocitrate Dehydrogenase><Isocitrates><Lead><Mixed Function Oxidases><Mixed Function Oxygenases><Modeling><Modern Man><Molecular><Monooxygenases><Mutation><Negative Control of Cell Proliferation><Negative Regulation of Cell Proliferation><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neuroglial Neoplasm><Neuroglial Tumor><Neurons><Oncogenesis><Oncoprotein p53><Organoids><P53><Pathway interactions><Patients><Pb element><Phosphoprotein P53><Phosphoprotein pp53><Progenitor Cells><Proliferating><Protein TP53><Publishing><Recombinant DNA Technology><Research><Role><Sequence Alteration><Somatic Cell><Source><Structure><System><TP53><TP53 gene><TRP53><Therapeutic Intervention><Tissue Growth><Transplantation><Tumor Promotion><Tumor Protein p53><Tumor Protein p53 Gene><Xenograft><Xenograft procedure><Xenotransplantation><adult youth><adulthood><alpha ketoglutarate><alpha thalassemia mental retardation X-linked gene><astrocytic glia><brain cell><cell type><drug development><epigenome><genetically engineered><genome mutation><genomic alteration><genomic profiles><glial-derived tumor><glioblastoma multiforme><glioma genesis><hESC><heavy metal Pb><heavy metal lead><human ES cell><human ESC><human derived pluripotent stem cell><human embryonic stem cell><human pluripotent stem cell><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intervention therapy><knock-down><knockdown><model of animal><mortality><mouse model><murine model><mutant><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neuro-oncology><neurogenic progenitors><neurogenic stem cell><neuroglia neoplasm><neuroglia tumor><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neurooncology><neuroprogenitor><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><ontogeny><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pathway><permissiveness><progenitor and neural stem cells><progenitor biology><progenitor cell biology><protein p53><shRNA><short hairpin RNA><small hairpin RNA><social role><spongioblastoma multiforme><stem and progenitor biology><stem cell biology><stem cells><transplant><tumor><tumor xenograft><tumorigenesis><tumorigenic><tumors in the brain><xeno-transplant><xeno-transplantation><young adult><young adult age><young adulthood><α-ketoglutarate><α-oxoglutarate><α-thalassemia mental retardation X-linked gene><αKG>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

How to Use PI Funding Data for Career Decisions

Finding the right principal investigator is one of the most important decisions in an academic career. Whether you are a postdoc looking for a mentor, a graduate student choosing a rotation lab, or a collaborator seeking a co-PI, NIH funding data provides objective signals about which investigators have active research programs and resources to support new team members.

A PI with a recently awarded R01 or equivalent grant is more likely to have budget for new personnel than one whose funding ended two years ago. The activity code tells you the type of grant: R01 and R35 awards typically support multiple lab members, while K-series awards are individual career development grants that may not fund additional positions. Understanding these distinctions helps you interpret search results accurately.

Look beyond the dollar amount. A $500,000 per year R01 at a high-cost institution may support fewer positions than a $300,000 award at a university with lower overhead rates. The project abstract and public health relevance statement reveal whether the PI's research direction aligns with your interests and expertise.

Understanding PI Grant Portfolios

A PI's grant portfolio reveals more than individual awards. Investigators with multiple active grants often run larger labs with more diverse projects, which can mean more opportunities for trainees. However, a PI with a single well-funded grant may offer more focused mentorship and a clearer path to publications.

Multi-PI grants (those with more than one principal investigator listed) indicate collaborative research and may involve trainees from multiple institutions. These can be excellent opportunities for interdisciplinary training but may also mean split attention from any single mentor.

Pay attention to the timing of awards. A PI who just received a new five-year R01 is in a different position than one whose grant ends next year. New awards often correspond to lab expansion and active recruiting, making them ideal targets for job seekers. The start and end dates shown in each result help you assess this timing.

Best Practices for Contacting Funded PIs

Once you identify a promising PI through this tool, the next step is outreach. NIH public records do not include email addresses, but you can usually find contact information through the PI's institutional profile page, lab website, or recent publications. Google Scholar, PubMed, and the PI's department website are reliable starting points.

When reaching out, reference the specific grant that caught your attention. Mentioning the project title and explaining how your skills relate to the funded work shows that you have done your homework. Keep your initial message concise: introduce yourself, explain your interest, attach your CV, and ask whether they anticipate openings.

Timing matters. Contacting a PI within the first year of a new award is ideal, as this is when they are most likely to be recruiting. If you find multiple promising PIs in the same field, prioritize those with the most recent award notices and activity codes that support trainee positions such as R01, U01, or P-series grants.

Frequently Asked Questions About PI Search

What does the opportunity score mean?

The opportunity score is a heuristic that combines award recency, funding amount, activity code type, and project characteristics to estimate how actionable a result might be for job seekers or collaborators. Higher scores suggest stronger signals, but always verify by reading the abstract and checking the PI's current lab page.

Why can't I find a PI I know has funding?

Name variations are the most common cause. Try searching with just the last name, or use different formats like "Smith, John" versus "John Smith." Some PIs also publish under different name variations or may have awards under a previous institutional affiliation.

Does this tool show all NIH-funded PIs?

The tool searches NIH RePORTER data for the keyword and year range you specify. It returns PIs whose funded projects match your search terms. PIs with grants in unrelated areas or whose projects use different terminology will not appear in keyword-filtered results.

What is the difference between "Likely hiring" and "Training-friendly" filters?

"Likely hiring" flags PIs with large new awards or activity codes typically associated with lab expansion. "Training-friendly" identifies awards that include training components or are at institutions known for postdoctoral programs. Both are heuristic filters to help prioritize your outreach.

How to use this well

Start broad, then narrow. Search a field first, then refine by timeframe once you understand who is currently active.

After you find a promising PI, cross-check them in Check PI Funding and review their institution, mechanism type, and project abstracts before reaching out.

What a match means

A result means the keyword appears relevant to the funded project data we searched. It does not guarantee the PI is hiring or that the grant is still active.

Use the abstract, award year, mechanism, and organization context to decide whether the record is strategically relevant.

Data limits

NIH records can lag, institutional names can vary, and some investigators publish or file awards under multiple name formats.

For details on source coverage and refresh cadence, read Data & Methodology.

Related guides

Companion guides for turning a PI search result into useful outreach or a job lead.

Career Guide8 min read

How Postdocs Can Find PIs with New NIH Funding

A tactical job-search guide for identifying recently funded labs, judging fit, and timing outreach to principal investigators.

Read guide
Career Guide7 min read

How to Contact a PI: Finding Emails and Crafting the Perfect Message

Emailing strategies, outreach examples, and a workflow for turning NIH funding signals into focused PI conversations.

Read guide
Career Guide10 min read

How to Read a New NIH Award Like a Hiring Signal

A practical framework for using newly funded NIH awards to judge whether a lab may be expanding, hiring, or worth contacting now.

Read guide
Funding Strategy16 min read

How to Find NIH Funding Opportunities: A Step-by-Step Guide for Researchers

Learn how to find NIH funding opportunities using the NIH Guide, Grants.gov, FOAs, NIH RePORTER, and program officer outreach.

Read guide

Recently Funded Labs in Trending Areas

Principal investigators who received NIH awards in the last 90 days, organized by research area. Use this as a starting point for postdoc searches, collaborator outreach, or competitor scans. Counts and labs refresh daily.

Alzheimer's disease

Neurodegeneration, biomarkers, and disease-modifying therapies.

  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $101,153 · awarded Feb 25, 2026 · 3U01AG084514-01A1S1
  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $3,086,339 · awarded Feb 19, 2026 · 1U01AG084514-01A1
  • Jonathan Haines — CASE WESTERN RESERVE UNIVERSITY, OH
    Alzheimer Disease Genetic Analysis to Identify Potential Therapeutic Targets (ADAPTT)
    $1,256,627 · awarded Feb 4, 2026 · 1R01AG096172-01
  • HARALD SONTHEIMER — UNIVERSITY OF VIRGINIA, VA
    Extracellular matrix and memory impairments in Alzheimer disease
    $709,066 · awarded Apr 7, 2026 · 5R01AG085359-03
  • Keith Josephs — MAYO CLINIC ROCHESTER, MN
    The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies
    $643,670 · awarded Apr 1, 2026 · 5R01DC014942-09
Search more PIs in Alzheimer's disease →

CRISPR & gene editing

Therapeutic gene editing, base editing, and prime editing.

  • Claire Clelland — UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, CA
    CRISPR for tauopathy
    $680,792 · awarded Jan 30, 2026 · 1R01AG092420-01
  • Changchun Liu — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT
    Asymmetric CRISPR Approach for Nucleic Acid Quantification
    $643,849 · awarded Mar 30, 2026 · 2R01EB023607-06A1
  • William Pu — BOSTON CHILDREN'S HOSPITAL, MA
    A modular system for murine CRISPR genome and epigenome editing
    $202,920 · awarded Mar 27, 2026 · 5R21OD037909-02
  • Naama Aviram — SLOAN-KETTERING INST CAN RESEARCH, NY
    Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systems
    $249,000 · awarded Apr 2, 2026 · 5R00GM148720-04
  • Mats Ljungman — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Precision targeting of bladder cancer using CRISPR
    $582,849 · awarded Feb 17, 2026 · 5R01CA285730-03
Search more PIs in CRISPR & gene editing →

Cancer immunotherapy

Checkpoint inhibitors, CAR-T, TIL therapy, and beyond.

  • TERRY SHEPPARD — KEYSTONE SYMPOSIA, CO
    Cancer Immunotherapy: Basic Mechanisms Informing Clinical Applications & Combinations
    $5,000 · awarded Mar 3, 2026 · 1R13CA310704-01
  • Veronika Fedirko — UNIVERSITY OF TX MD ANDERSON CAN CTR, TX
    Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma
    $927,329 · awarded Mar 3, 2026 · 5R01CA255322-05
  • Yuwen Zhu — UNIVERSITY OF COLORADO DENVER, CO
    The GPR171 pathway in cancer immunotherapy
    $355,706 · awarded Apr 2, 2026 · 5R01CA279398-04
  • Wei Hu — YALE UNIVERSITY, CT
    Novel Treg inactivating approach for cancer immunotherapy via targeted protein degradation
    $482,312 · awarded Apr 6, 2026 · 1R01CA295942-01A1
  • Laurent Gapin — UNIVERSITY OF COLORADO DENVER, CO
    Development and Characterization of the MAIT-Boost Knock-In (MBKI) Mouse to Investigate MAIT Cell Biology and Cancer Immunotherapy
    $429,000 · awarded Jan 30, 2026 · 1R21AI195296-01
Search more PIs in Cancer immunotherapy →

GLP-1 & metabolic disease

Diabetes, obesity, and weight-loss therapeutic mechanisms.

  • Xiaomo Xiong — UNIVERSITY OF CINCINNATI, OH
    GLP-1 Agonists for Preventing Alzheimer's Disease in Mild Cognitive Impairment
    $324,000 · awarded Feb 5, 2026 · 1R03AG098738-01
  • STEVEN SCHWENDEMAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Remote Loading of Melanocortin and GLP-1 Peptides in Polymers for Treatment of Obesity
    $231,000 · awarded Apr 17, 2026 · 1R56DK141545-01A1
  • JENNIFER ST SAUVER — MAYO CLINIC ROCHESTER, MN
    Real world impact of glucagon-like peptide receptor agonist (GLP-1 RA) use on older adults
    $443,850 · awarded Mar 13, 2026 · 1R21AG097887-01
  • Naykky Singh Ospina — UNIVERSITY OF FLORIDA, FL
    Navigating the Uncertainties of Thyroid Cancer Risk in GLP-1RA Users
    $694,122 · awarded Mar 24, 2026 · 1R01CA299220-01A1
  • Patricia Grigson — PENNSYLVANIA STATE UNIV HERSHEY MED CTR, PA
    Cocaine Addition and the Need-State Hypothesis
    $667,063 · awarded Feb 26, 2026 · 5R01DA060250-02
Search more PIs in GLP-1 & metabolic disease →

Long COVID

Post-acute sequelae and chronic infection-driven illness.

  • Alexei Tumanov — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX
    Lymphotoxin-dependent control of long COVID
    $234,715 · awarded Feb 13, 2026 · 1R21AI185790-01A1
  • E ELY — VANDERBILT UNIVERSITY MEDICAL CENTER, TN
    REVERSE-Long COVID: A Multicenter Randomized, Placebo-Controlled Clinical Trial of Immunomodulation (with Baricitinib) for Long COVID Related ADRD
    $6,778,156 · awarded Feb 6, 2026 · 5R01AG085873-03
  • Amal Amer — OHIO STATE UNIVERSITY, OH
    Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
    $2,974,582 · awarded Apr 21, 2026 · 5P01AI175399-03
  • Alba Azola — JOHNS HOPKINS UNIVERSITY, MD
    Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 onset ME/CFS versus Pre-Pandemic ME/CFS Patients
    $633,378 · awarded Apr 17, 2026 · 1R01NS147100-01
  • DANIELLE REED — MONELL CHEMICAL SENSES CENTER, PA
    Inflammation and chemosensory loss
    $2,654,249 · awarded Feb 26, 2026 · 1P50DC022549-01A1
Search more PIs in Long COVID →