Andrew S Huhn

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

High-opportunity lead · 80/100

Likely hiring

Large award

Recent

Active award

$5,833,132

FY 2026

Project Title

Phase III double-blind, randomized controlled trial of suvorexant versus placebo to treat insomnia in persons with opioid use disorder

Grant Number:

5U01DA060708-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2024

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Opioid use disorder (OUD) is a rapidly escalating public health crisis with recent evidence suggesting that close to 70% of drug overdose deaths involved opioids in the last year. Medications for OUD (MOUDs) such as buprenorphine and methadone are the frontline treatment for OUD, yet over half of in...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Katharina Maria Busl

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

High-opportunity lead · 74/100

Likely hiring

Large award

Active award

Team-scale grant

$3,419,550

FY 2026

Project Title

Pterygopalatine Fossa (PPF) Block as an Opioid Sparing Treatment for AcuteHeadache in Aneurysmal Subarachnold Hemorrhage

Grant Number:

5U01NS124613-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Severe headache is ubiquitous in subarachnoid hemorrhage (SAH), present in 90% of patients after ictus bleed. Despite steady consumption of analgesics, the degree of pain control in SAH patients is remarkably poor. In spite of this high prevalence, a dearth of data guides optimal management of post-...

Research Terms

<21+ years old><Absence of pain sensation><Absence of sensibility to pain><Active Follow-up><Activities of Daily Living><Activities of everyday life><Acute><Acute Brain Injuries><Acute Pain><Acutely painful><Address><Adult><Adult Human><Adverse Experience><Adverse event><Affect><Analgesia Tests><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anesthesiology><Aneurysm><Aneurysmal Subarachnoid Hemorrhages><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Bilateral><Bleeding><Blinded><Blood Vessels><Brain Vascular><Caring><Cephalalgia><Cephalgia><Cephalgia Syndromes><Cephalodynia><Chronic Headaches><Clinical><Clinical Trials><Common Data Element><Complex><Conscious><Consciousness><Constipation><Consumption><Cranial Pain><Critical Care><Dangerousness><Data><Data Coordinating Center><Data Coordination Center><Depressed Level of Consciousness><Depressed mood><Dexamethasone><Disparities><Disparity><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Dysfunction><Echography><Echotomography><Enrollment><Ethnic Origin><Ethnicity><Feels no pain><Fiber><Fossa><Frequencies><Functional disorder><Funding><Future><Ganglia><Gastrointestinal Transit><Generations><Goals><Grant><Head Pain><Headache><Headache Disorders><Hemorrhage><High Prevalence><Hospital Admission><Hospitalization><Hospitals><Hour><Hyperalgesia><Hyperalgesic Sensations><Hypotension><Individual><Individuals from minority><Individuals of minority><Inflammatory><Injections><Intervention><Intervention Studies><Knowledge><Lead><Learning><Literature><Low Blood Pressure><Managed Care><Massachusetts><Measures><Mediating><Medical Ultrasound><Meningeal><Migraine><Migraine Headache><Minority Groups><Minority People><Minority Population><Minority individual><NIH><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Nerve Block><Neural Block><Neural Blockade><Neural Ganglion><New York><No sensitivity to pain><Nociception Tests><Numeric Rating Scale><Numerical Scale><Opiates><Opioid><Oral><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Research><Pain Therapy><Pain intensity><Pain management><Pain measure><Painful><Patients><Pb element><Phase><Physiopathology><Placebo Effect><Procedures><Race><Races><Randomized><Recovery><Regimen><Regulation><Research Design><Risk><Safety><Saline><Saline Solution><Sample Size><Serious Adverse Event><Severe Adverse Event><Severities><Site><Standardization><Study Type><Subarachnoid Hemorrhage><Survivors><Therapeutic><Thunderclap Headaches><Time><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><United States National Institutes of Health><Universities><Vascular Hypotensive Disorder><Vasomotor><Vasospasm><Woman><Work><active followup><addiction><addictive disorder><adjudication><adjudicative process and procedure><adulthood><analgesia><blood loss><blood product><central pain><central sensitization><cerebral vascular><cerebro-vascular><cerebrovascular><clinical significance><clinically significant><cortical pain><craniofacial><craniofacies><cytokine><daily living function><daily living functionality><depressed><design><designing><diagnostic ultrasound><disparities in race><disparities in sex><disparity due to race><enroll><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><expectancy effect><expectation effect><experience><follow up><follow-up><followed up><followup><functional ability><functional capacity><head ache><heavy metal Pb><heavy metal lead><hospital re-admission><hospital readmission><hyperalgia><improved><inequality due to race><inequity due to race><innovate><innovation><innovative><instrument><intervention research><interventional research><interventional study><interventions research><irritation><licit opioid><maxillary nerve><morphine equivalence><morphine equivalent><multi-modality><multimodality><neglect><neurosurgery><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><nocebo><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><open label><open label study><opiate consumption><opiate crisis><opiate deaths><opiate drug use><opiate intake><opiate medication><opiate mortality><opiate use><opioid consumption><opioid crisis><opioid deaths><opioid drug use><opioid epidemic><opioid intake><opioid medication><opioid mortality><opioid overdose death><opioid related death><opioid sparing><opioid use><pain assay><pain intervention><pain killer><pain medication><pain perception><pain reduction><pain reliever><pain score><pain treatment><painkiller><pathophysiology><phase 3 trial><phase III trial><placebo controlled study><placebo response><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial minority group><racial minority individual><racial minority people><racial minority population><racial origin><racially unequal><randomisation><randomization><randomly assigned><re-admission><re-hospitalization><readmission><recruit><reduce pain><rehospitalization><respiratory><response><ropivacaine><sadness><serious adverse experience><serious adverse reaction><sex><sex disparity><side effect><socio-demographic factors><socio-economic><socio-economically><sociodemographic factors><socioeconomically><socioeconomics><sonogram><sonography><sound measurement><study design><theories><ultrasound><ultrasound imaging><ultrasound scanning><vascular><verbal>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Brian Lim Hoh

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

High-opportunity lead · 74/100

Likely hiring

Large award

Active award

Team-scale grant

$3,419,550

FY 2026

Project Title

Pterygopalatine Fossa (PPF) Block as an Opioid Sparing Treatment for AcuteHeadache in Aneurysmal Subarachnold Hemorrhage

Grant Number:

5U01NS124613-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Severe headache is ubiquitous in subarachnoid hemorrhage (SAH), present in 90% of patients after ictus bleed. Despite steady consumption of analgesics, the degree of pain control in SAH patients is remarkably poor. In spite of this high prevalence, a dearth of data guides optimal management of post-...

Research Terms

<21+ years old><Absence of pain sensation><Absence of sensibility to pain><Active Follow-up><Activities of Daily Living><Activities of everyday life><Acute><Acute Brain Injuries><Acute Pain><Acutely painful><Address><Adult><Adult Human><Adverse Experience><Adverse event><Affect><Analgesia Tests><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anesthesiology><Aneurysm><Aneurysmal Subarachnoid Hemorrhages><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Bilateral><Bleeding><Blinded><Blood Vessels><Brain Vascular><Caring><Cephalalgia><Cephalgia><Cephalgia Syndromes><Cephalodynia><Chronic Headaches><Clinical><Clinical Trials><Common Data Element><Complex><Conscious><Consciousness><Constipation><Consumption><Cranial Pain><Critical Care><Dangerousness><Data><Data Coordinating Center><Data Coordination Center><Depressed Level of Consciousness><Depressed mood><Dexamethasone><Disparities><Disparity><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Dysfunction><Echography><Echotomography><Enrollment><Ethnic Origin><Ethnicity><Feels no pain><Fiber><Fossa><Frequencies><Functional disorder><Funding><Future><Ganglia><Gastrointestinal Transit><Generations><Goals><Grant><Head Pain><Headache><Headache Disorders><Hemorrhage><High Prevalence><Hospital Admission><Hospitalization><Hospitals><Hour><Hyperalgesia><Hyperalgesic Sensations><Hypotension><Individual><Individuals from minority><Individuals of minority><Inflammatory><Injections><Intervention><Intervention Studies><Knowledge><Lead><Learning><Literature><Low Blood Pressure><Managed Care><Massachusetts><Measures><Mediating><Medical Ultrasound><Meningeal><Migraine><Migraine Headache><Minority Groups><Minority People><Minority Population><Minority individual><NIH><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Nerve Block><Neural Block><Neural Blockade><Neural Ganglion><New York><No sensitivity to pain><Nociception Tests><Numeric Rating Scale><Numerical Scale><Opiates><Opioid><Oral><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Research><Pain Therapy><Pain intensity><Pain management><Pain measure><Painful><Patients><Pb element><Phase><Physiopathology><Placebo Effect><Procedures><Race><Races><Randomized><Recovery><Regimen><Regulation><Research Design><Risk><Safety><Saline><Saline Solution><Sample Size><Serious Adverse Event><Severe Adverse Event><Severities><Site><Standardization><Study Type><Subarachnoid Hemorrhage><Survivors><Therapeutic><Thunderclap Headaches><Time><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><United States National Institutes of Health><Universities><Vascular Hypotensive Disorder><Vasomotor><Vasospasm><Woman><Work><active followup><addiction><addictive disorder><adjudication><adjudicative process and procedure><adulthood><analgesia><blood loss><blood product><central pain><central sensitization><cerebral vascular><cerebro-vascular><cerebrovascular><clinical significance><clinically significant><cortical pain><craniofacial><craniofacies><cytokine><daily living function><daily living functionality><depressed><design><designing><diagnostic ultrasound><disparities in race><disparities in sex><disparity due to race><enroll><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><expectancy effect><expectation effect><experience><follow up><follow-up><followed up><followup><functional ability><functional capacity><head ache><heavy metal Pb><heavy metal lead><hospital re-admission><hospital readmission><hyperalgia><improved><inequality due to race><inequity due to race><innovate><innovation><innovative><instrument><intervention research><interventional research><interventional study><interventions research><irritation><licit opioid><maxillary nerve><morphine equivalence><morphine equivalent><multi-modality><multimodality><neglect><neurosurgery><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><nocebo><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><open label><open label study><opiate consumption><opiate crisis><opiate deaths><opiate drug use><opiate intake><opiate medication><opiate mortality><opiate use><opioid consumption><opioid crisis><opioid deaths><opioid drug use><opioid epidemic><opioid intake><opioid medication><opioid mortality><opioid overdose death><opioid related death><opioid sparing><opioid use><pain assay><pain intervention><pain killer><pain medication><pain perception><pain reduction><pain reliever><pain score><pain treatment><painkiller><pathophysiology><phase 3 trial><phase III trial><placebo controlled study><placebo response><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial minority group><racial minority individual><racial minority people><racial minority population><racial origin><racially unequal><randomisation><randomization><randomly assigned><re-admission><re-hospitalization><readmission><recruit><reduce pain><rehospitalization><respiratory><response><ropivacaine><sadness><serious adverse experience><serious adverse reaction><sex><sex disparity><side effect><socio-demographic factors><socio-economic><socio-economically><sociodemographic factors><socioeconomically><socioeconomics><sonogram><sonography><sound measurement><study design><theories><ultrasound><ultrasound imaging><ultrasound scanning><vascular><verbal>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Carolina B Maciel

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

High-opportunity lead · 74/100

Likely hiring

Large award

Active award

Team-scale grant

$3,419,550

FY 2026

Project Title

Pterygopalatine Fossa (PPF) Block as an Opioid Sparing Treatment for AcuteHeadache in Aneurysmal Subarachnold Hemorrhage

Grant Number:

5U01NS124613-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Severe headache is ubiquitous in subarachnoid hemorrhage (SAH), present in 90% of patients after ictus bleed. Despite steady consumption of analgesics, the degree of pain control in SAH patients is remarkably poor. In spite of this high prevalence, a dearth of data guides optimal management of post-...

Research Terms

<21+ years old><Absence of pain sensation><Absence of sensibility to pain><Active Follow-up><Activities of Daily Living><Activities of everyday life><Acute><Acute Brain Injuries><Acute Pain><Acutely painful><Address><Adult><Adult Human><Adverse Experience><Adverse event><Affect><Analgesia Tests><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anesthesiology><Aneurysm><Aneurysmal Subarachnoid Hemorrhages><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Bilateral><Bleeding><Blinded><Blood Vessels><Brain Vascular><Caring><Cephalalgia><Cephalgia><Cephalgia Syndromes><Cephalodynia><Chronic Headaches><Clinical><Clinical Trials><Common Data Element><Complex><Conscious><Consciousness><Constipation><Consumption><Cranial Pain><Critical Care><Dangerousness><Data><Data Coordinating Center><Data Coordination Center><Depressed Level of Consciousness><Depressed mood><Dexamethasone><Disparities><Disparity><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Dysfunction><Echography><Echotomography><Enrollment><Ethnic Origin><Ethnicity><Feels no pain><Fiber><Fossa><Frequencies><Functional disorder><Funding><Future><Ganglia><Gastrointestinal Transit><Generations><Goals><Grant><Head Pain><Headache><Headache Disorders><Hemorrhage><High Prevalence><Hospital Admission><Hospitalization><Hospitals><Hour><Hyperalgesia><Hyperalgesic Sensations><Hypotension><Individual><Individuals from minority><Individuals of minority><Inflammatory><Injections><Intervention><Intervention Studies><Knowledge><Lead><Learning><Literature><Low Blood Pressure><Managed Care><Massachusetts><Measures><Mediating><Medical Ultrasound><Meningeal><Migraine><Migraine Headache><Minority Groups><Minority People><Minority Population><Minority individual><NIH><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Nerve Block><Neural Block><Neural Blockade><Neural Ganglion><New York><No sensitivity to pain><Nociception Tests><Numeric Rating Scale><Numerical Scale><Opiates><Opioid><Oral><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Research><Pain Therapy><Pain intensity><Pain management><Pain measure><Painful><Patients><Pb element><Phase><Physiopathology><Placebo Effect><Procedures><Race><Races><Randomized><Recovery><Regimen><Regulation><Research Design><Risk><Safety><Saline><Saline Solution><Sample Size><Serious Adverse Event><Severe Adverse Event><Severities><Site><Standardization><Study Type><Subarachnoid Hemorrhage><Survivors><Therapeutic><Thunderclap Headaches><Time><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><United States National Institutes of Health><Universities><Vascular Hypotensive Disorder><Vasomotor><Vasospasm><Woman><Work><active followup><addiction><addictive disorder><adjudication><adjudicative process and procedure><adulthood><analgesia><blood loss><blood product><central pain><central sensitization><cerebral vascular><cerebro-vascular><cerebrovascular><clinical significance><clinically significant><cortical pain><craniofacial><craniofacies><cytokine><daily living function><daily living functionality><depressed><design><designing><diagnostic ultrasound><disparities in race><disparities in sex><disparity due to race><enroll><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><expectancy effect><expectation effect><experience><follow up><follow-up><followed up><followup><functional ability><functional capacity><head ache><heavy metal Pb><heavy metal lead><hospital re-admission><hospital readmission><hyperalgia><improved><inequality due to race><inequity due to race><innovate><innovation><innovative><instrument><intervention research><interventional research><interventional study><interventions research><irritation><licit opioid><maxillary nerve><morphine equivalence><morphine equivalent><multi-modality><multimodality><neglect><neurosurgery><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><nocebo><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><open label><open label study><opiate consumption><opiate crisis><opiate deaths><opiate drug use><opiate intake><opiate medication><opiate mortality><opiate use><opioid consumption><opioid crisis><opioid deaths><opioid drug use><opioid epidemic><opioid intake><opioid medication><opioid mortality><opioid overdose death><opioid related death><opioid sparing><opioid use><pain assay><pain intervention><pain killer><pain medication><pain perception><pain reduction><pain reliever><pain score><pain treatment><painkiller><pathophysiology><phase 3 trial><phase III trial><placebo controlled study><placebo response><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial minority group><racial minority individual><racial minority people><racial minority population><racial origin><racially unequal><randomisation><randomization><randomly assigned><re-admission><re-hospitalization><readmission><recruit><reduce pain><rehospitalization><respiratory><response><ropivacaine><sadness><serious adverse experience><serious adverse reaction><sex><sex disparity><side effect><socio-demographic factors><socio-economic><socio-economically><sociodemographic factors><socioeconomically><socioeconomics><sonogram><sonography><sound measurement><study design><theories><ultrasound><ultrasound imaging><ultrasound scanning><vascular><verbal>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Cameron Reid Smith

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

High-opportunity lead · 74/100

Likely hiring

Large award

Active award

Team-scale grant

$3,419,550

FY 2026

Project Title

Pterygopalatine Fossa (PPF) Block as an Opioid Sparing Treatment for AcuteHeadache in Aneurysmal Subarachnold Hemorrhage

Grant Number:

5U01NS124613-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Severe headache is ubiquitous in subarachnoid hemorrhage (SAH), present in 90% of patients after ictus bleed. Despite steady consumption of analgesics, the degree of pain control in SAH patients is remarkably poor. In spite of this high prevalence, a dearth of data guides optimal management of post-...

Research Terms

<21+ years old><Absence of pain sensation><Absence of sensibility to pain><Active Follow-up><Activities of Daily Living><Activities of everyday life><Acute><Acute Brain Injuries><Acute Pain><Acutely painful><Address><Adult><Adult Human><Adverse Experience><Adverse event><Affect><Analgesia Tests><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anesthesiology><Aneurysm><Aneurysmal Subarachnoid Hemorrhages><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Bilateral><Bleeding><Blinded><Blood Vessels><Brain Vascular><Caring><Cephalalgia><Cephalgia><Cephalgia Syndromes><Cephalodynia><Chronic Headaches><Clinical><Clinical Trials><Common Data Element><Complex><Conscious><Consciousness><Constipation><Consumption><Cranial Pain><Critical Care><Dangerousness><Data><Data Coordinating Center><Data Coordination Center><Depressed Level of Consciousness><Depressed mood><Dexamethasone><Disparities><Disparity><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Dysfunction><Echography><Echotomography><Enrollment><Ethnic Origin><Ethnicity><Feels no pain><Fiber><Fossa><Frequencies><Functional disorder><Funding><Future><Ganglia><Gastrointestinal Transit><Generations><Goals><Grant><Head Pain><Headache><Headache Disorders><Hemorrhage><High Prevalence><Hospital Admission><Hospitalization><Hospitals><Hour><Hyperalgesia><Hyperalgesic Sensations><Hypotension><Individual><Individuals from minority><Individuals of minority><Inflammatory><Injections><Intervention><Intervention Studies><Knowledge><Lead><Learning><Literature><Low Blood Pressure><Managed Care><Massachusetts><Measures><Mediating><Medical Ultrasound><Meningeal><Migraine><Migraine Headache><Minority Groups><Minority People><Minority Population><Minority individual><NIH><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Nerve Block><Neural Block><Neural Blockade><Neural Ganglion><New York><No sensitivity to pain><Nociception Tests><Numeric Rating Scale><Numerical Scale><Opiates><Opioid><Oral><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Research><Pain Therapy><Pain intensity><Pain management><Pain measure><Painful><Patients><Pb element><Phase><Physiopathology><Placebo Effect><Procedures><Race><Races><Randomized><Recovery><Regimen><Regulation><Research Design><Risk><Safety><Saline><Saline Solution><Sample Size><Serious Adverse Event><Severe Adverse Event><Severities><Site><Standardization><Study Type><Subarachnoid Hemorrhage><Survivors><Therapeutic><Thunderclap Headaches><Time><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><United States National Institutes of Health><Universities><Vascular Hypotensive Disorder><Vasomotor><Vasospasm><Woman><Work><active followup><addiction><addictive disorder><adjudication><adjudicative process and procedure><adulthood><analgesia><blood loss><blood product><central pain><central sensitization><cerebral vascular><cerebro-vascular><cerebrovascular><clinical significance><clinically significant><cortical pain><craniofacial><craniofacies><cytokine><daily living function><daily living functionality><depressed><design><designing><diagnostic ultrasound><disparities in race><disparities in sex><disparity due to race><enroll><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><expectancy effect><expectation effect><experience><follow up><follow-up><followed up><followup><functional ability><functional capacity><head ache><heavy metal Pb><heavy metal lead><hospital re-admission><hospital readmission><hyperalgia><improved><inequality due to race><inequity due to race><innovate><innovation><innovative><instrument><intervention research><interventional research><interventional study><interventions research><irritation><licit opioid><maxillary nerve><morphine equivalence><morphine equivalent><multi-modality><multimodality><neglect><neurosurgery><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><nocebo><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><open label><open label study><opiate consumption><opiate crisis><opiate deaths><opiate drug use><opiate intake><opiate medication><opiate mortality><opiate use><opioid consumption><opioid crisis><opioid deaths><opioid drug use><opioid epidemic><opioid intake><opioid medication><opioid mortality><opioid overdose death><opioid related death><opioid sparing><opioid use><pain assay><pain intervention><pain killer><pain medication><pain perception><pain reduction><pain reliever><pain score><pain treatment><painkiller><pathophysiology><phase 3 trial><phase III trial><placebo controlled study><placebo response><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial minority group><racial minority individual><racial minority people><racial minority population><racial origin><racially unequal><randomisation><randomization><randomly assigned><re-admission><re-hospitalization><readmission><recruit><reduce pain><rehospitalization><respiratory><response><ropivacaine><sadness><serious adverse experience><serious adverse reaction><sex><sex disparity><side effect><socio-demographic factors><socio-economic><socio-economically><sociodemographic factors><socioeconomically><socioeconomics><sonogram><sonography><sound measurement><study design><theories><ultrasound><ultrasound imaging><ultrasound scanning><vascular><verbal>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

HEATH D SCHMIDT

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$796,627

FY 2026

Project Title

The role of central amylin receptor in opioid-mediated behaviors

Grant Number:

5R01DA061799-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The opioid epidemic remains a major public health crisis in the U.S. Despite the effectiveness of current FDA- approved medications to treat opioid use disorder (OUD), there is still a high rate of relapse following detoxification. Thus, there is a critical need for conceptually new ...

Research Terms

<21+ years old><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><Abstinence><Access to Care><Acute><Adult><Adult Human><Aminalon><Aminalone><Attenuated><Behavior><Behavioral><Brain><Brain Nervous System><Calcium><Cell Body><Cell Nucleus><Cells><Clinical><Clinical Research><Clinical Study><Common Rat Strains><Corpus Striatum><Corpus striatum structure><D1 receptor><D2 receptor><DA Neuron><DRD2 Receptor><Development><Diagnosis><Dihydrohydroxycodeinone><Dopamine><Dopamine D1 Receptor><Dopamine D2 Receptor><Dopamine neuron><Dose><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Drug Targeting><Drug Therapy><Drugs><Eating><Effectiveness><Encephalon><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Female><Fiber><Food><Food Intake><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Future><GABA><Gene Delivery><Genes><Goals><Health Services Accessibility><Humulin R><Hydroxytyramine><IAPP receptor><Individual><Infusion><Infusion procedures><Injections><Insulin><Insulinoma amyloid peptide><Intake><Knowledge><Maps><Mediating><Medication><Mesencephalon><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Methods><Mid-brain><Midbrain><Midbrain structure><Molecular><Nerve Cells><Nerve Unit><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurocyte><Neurons><Neuropeptides><Novolin R><Nucleus><Nucleus Accumbens><Opiates><Opioid><Opioid Analgesics><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Pancreatic beta Cell><Pancreatic β-Cell><Pattern><Peptide Hormone Gene><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Photometry><Pilot Projects><Population><Public Health><Rat><Rat Transgene><Rats Mammals><Rattus><Receptor Activation><Receptor Signaling><Regular Insulin><Relapse><Research><Rewards><Rodent Model><Role><Roxicodone><Saline><Saline Solution><Satiation><Self Administered><Self Administration><Single-Nucleus Sequencing><Specificity><Stimulus><Striate Body><Striatum><Structure of beta Cell of islet><System><Techniques><Testing><Time><United States><Ventral Tegmental Area><Viral><access to health services><access to services><access to treatment><accessibility to health services><addiction><addictive disorder><adulthood><amlintide><amylin><amylin receptor><analog><antinociception><antinociceptive><attenuate><attenuates><availability of services><care access><cell type><determine efficacy><detoxification><developmental><diabetes associated peptide><differential expression><differentially expressed><dopaminergic neuron><drug development><drug intervention><drug treatment><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experience><experiences among men><experiment><experimental research><experimental study><experiments><gamma-Aminobutyric Acid><health service access><health services availability><hedonic><in vivo><infusions><innovate><innovation><innovative><insight><insulinoma amyloid polypeptide><islet amyloid polypeptide><islet amyloid polypeptide receptor><knock-down><knockdown><licit opioid><male experience><men's experience><neural circuit><neural circuitry><neural mechanism><neurobiological mechanism><neurocircuitry><neuromechanism><neuronal><neuronal excitability><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><opiate analgesia><opiate analgesic><opiate crisis><opiate medication><opiate pain medication><opiate pain reliever><opiate therapy><opiate use disorder><opioid analgesia><opioid anesthetic><opioid crisis><opioid epidemic><opioid medication><opioid pain medication><opioid pain reliever><opioid painkiller><opioid therapy><opioid use disorder><overdose death><overdose fatalities><oxycodone self-administration><pancreas beta cell><pancreas β cell><pancreatic amylin><pancreatic b-cell><peptide hormone><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pilot study><pre-clinical study><preclinical study><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><receptor expression><response><sNuc-Seq><satiety><self-administer oxycodone><service availability><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><striatal><synaptic circuit><synaptic circuitry><transcriptional differences><transcriptomics><translation strategy><translational approach><translational strategy><treatment access><ventral tegmentum><γ-Aminobutyric Acid><♀>

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Steffani R Bailey

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$756,337

FY 2026

Project Title

OUTREACH: Opioid Use TReatment via telehEAlth in CHCs

Grant Number:

5R01DA060857-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Improving access to opioid use disorder (OUD) treatment is critical to curb opioid overdose rates in the United States. Alarmingly, only 25% of adults with an OUD receive opioid agonist or antagonist treatment. In March of 2020, telehealth policies were enacted to increase access to OUD treatment, i...

Research Terms

<21+ years old><Academy><Access to Care><Address><Adult><Adult Human><Affect><Age><American><Appointment><Area><Authorization><Authorization documentation><Black><Black race><Buprenorphine><Burn injury><Burns><COVID crisis><COVID epidemic><COVID pandemic><COVID-19><COVID-19 affected><COVID-19 consequence><COVID-19 crisis><COVID-19 effect><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 impact><COVID-19 impacted><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CV-19><California><Caring><Catalogs><Characteristics><Clinical><Communities><Community Health Centers><Community Health Networks><Complex><Coronavirus Infectious Disease 2019><Data><Data Set><Development><Diagnosis><Digit><Digit structure><Disparities><Disparity><Drugs><Effectiveness><Electronic Health Record><Engineering><Ensure><Epidemic><Ethnic Origin><Ethnicity><Evaluation><Family><Federally Qualified Health Center><Foundations><Future><Guidelines><Health><Health Care><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Health Policy><Health Promotion><Health Services><Health Services Accessibility><Improve Access><Incidence><Individual><Insurance Carriers><Insurers><Internships><Intervention><Journals><Knowledge><Link><Magazine><Medicaid><Medical><Medicare><Medication><Medicine><Methods><Modality><Monitor><NIDA><Napping><National Academy of Sciences><National Institute of Drug Abuse><National Institute on Drug Abuse><Neighborhood Health Center><Opiate Antagonist><Opiate agonist><Opiate receptor agonist><Opiate receptor antagonist><Opioid Antagonist><Opioid agonist><Opioid receptor agonist><Opioid receptor antagonist><Outcome><Overdose><Patients><Pattern><Permission><Persons><Pharmaceutical Preparations><Phone><Policies><Population><Position><Positioning Attribute><Primary Care><Provider><Psychiatry><QOC><Quality of Care><Race><Races><Recommendation><Research><Role><Rural><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Salutogenesis><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Social Change><Social modification><Social transformation><Societies><Socio-economic status><Socioeconomic Status><Strategic Planning><Technology><Telemedicine><Telephone><Text><Time><Title 18><Treatment Period><Uninsured><United States><United States National Academy of Sciences><Visit><access to health services><access to services><access to treatment><accessibility to health services><addiction><addictive disorder><adulthood><ages><availability of services><behavioral health><beneficiary><buprenorphine treatment><burned><care access><care delivery><catalog><community factor><community-level factor><coronavirus disease 2019><coronavirus disease 2019 consequence><coronavirus disease 2019 crisis><coronavirus disease 2019 effect><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 impact><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 impact><coronavirus disease-19 pandemic><coronavirus infectious disease-19><developmental><digital access><digital accessibility><digital disparities><digital divide><digital equality><digital equity><digital gap><digital inclusion><digital inequality><digital inequities><digital literacy><drug/agent><effective therapy><effective treatment><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><federal policy><fighting><health care policy><health care settings><health insurance for disabled><health service access><health services availability><insight><intern><medication for opioid use disorder><medication-assisted therapy><medication-assisted treatment><mortality><older adult><older adulthood><opiate consumption><opiate crisis><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid crisis><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid treatment program><opioid use><opioid use disorder><patient centered><patient oriented><patient population><patient retention><population based><primary care setting><programs><promoting health><public health emergency><racial><racial background><racial origin><rural area><rural location><rural region><safety net><service availability><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social role><socio-economic position><socioeconomic position><systematic review><tech-savviness><telehealth><telephone based><treatment access><treatment days><treatment duration><trend><video visit><younger age>

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Marta Filizola

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$750,256

FY 2026

Project Title

Leveraging Integrative Modeling and AI-Based Tools to Develop Safer Opioids

Grant Number:

5R01DA063209-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The misuse of opioid painkillers targeting the -opioid receptor (MOR) continues to result in record numbers of overdose deaths, underscoring the pressing need to identify safer analgesics, as well as effective therapies for opioid use disorder (OUD). Although efficacy with (e.g., pr...

Research Terms

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DALIBOR SAMES

COLUMBIA UNIV NEW YORK MORNINGSIDE, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$724,778

FY 2026

Project Title

Chemistry and Pharmacology of Iboga Alkaloids

Grant Number:

2R01DA050613-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2020

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Chemistry and Pharmacology of Iboga Alkaloids Ibogaine is the major psychoactive alkaloid of Tabernanthe iboga, a shrub native to West Central Africa. Ibogaine is largely known for its ability to interrupt drug dependence on opioids, cocaine, nicotine, and alcohol described in observational ...

Research Terms

<12-Methoxyibogamine><12-methoxy-ibogamine><2,3-benzofuran><21+ years old><Abstinence><Actiq><Address><Adult><Adult Human><Adverse effects><African><Alcohol Chemical Class><Alcohols><Alkaloids><Anochlesia><Assay><Behavioral><Benzofurans><Bioassay><Biological Assay><Blood Plasma><Brain Trauma><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Case Study><Case-Base Studies><Catalepsy><Categories><Cell Body><Cells><Central Africa><Chemical Dependence><Chemical Structure><Chemistry><Chemosensitization><Chemosensitization/Potentiation><Clinical Research><Clinical Study><Cocaine><Common Rat Strains><Complex><Coumarones><Coupling><Cues><Cyclicity><Data><Dependence><Development><Diacetylmorphine><Diagnostic><Diamorphine><Dose><Drug Addiction><Drug Dependence><Drug Dependency><Drug Kinetics><Drug Withdrawal Symptoms><Drugs><Duragesic><Emotional Depression><Ethers><Evaluation><Exhibits><Fentanest><Fentanyl><Fentyl><Foundations><Funding><Genes><Goals><Heart Muscle Cells><Heart myocyte><Heroin><Human><Hyperalgesia><Hyperalgesic Sensations><Iboga><Ibogaine><In Situ><In Vitro><Indoles><Intake><Interdisciplinary Research><Interdisciplinary Study><Interruption><Ion Channel><Ionic Channels><K channel><Laboratories><Lead><Maps><Mediating><Medication><Membrane Channels><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Metabolic><Methods><Mice><Mice Mammals><Microdialysis><Microsomes><Modeling><Modern Man><Molecular><Molecular Target><Multidisciplinary Collaboration><Multidisciplinary Research><Murine><Mus><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><NMDA Receptor-Ionophore Complex><NMDA Receptors><Neurologic><Neurological><Neuropharmacology><Ni element><Nickel><Nicotine><Nicotinic Acetylcholine Receptors><Nicotinic Receptors><Nitrogen><O element><O2 element><Observational Study><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid agonist><Opioid receptor agonist><Oxygen><PTSD><Palladium><Pb element><Pd element><Periodicity><Pharmaceutical Preparations><Pharmacodynamics><Pharmacokinetics><Pharmacology><Phentanyl><Plants><Plasma><Plasma Serum><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Potassium Channel><Potassium Ion Channels><Potentiation><Process><Psyche structure><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychological reinforcement><Rat><Rats Mammals><Rattus><Reaction><Receptor Protein><Receptor Signaling><Recommendation><Reinforcement><Relapse><Reporting><Research><Reticuloendothelial System, Serum, Plasma><Rhythmicity><Risk><Rodent><Rodent Model><Rodentia><Rodents Mammals><Safety><Sedation procedure><Self Administered><Self Administration><Series><Skeleton><Substance Use Disorder><System><Tabernanthe iboga><Testing><Therapeutic><Therapeutic Effect><Tissue Harvesting><Traumatic Brain Injury><Trees><Validation><abused drug><abused drugs><adulthood><alleviate symptom><ameliorating symptom><analog><antinociception><antinociceptive><anxiety symptoms><anxious symptom><aspartate receptor><aspartic acid receptor><benzo(b)furan><benzofurfuran><cardiomyocyte><case report><combat veteran><cycloaddition><decrease symptom><depression symptom><depressive><depressive symptoms><design><designing><determine efficacy><developmental><disease model><disorder model><drug abused><drug discovery><drug metabolism><drug of abuse><drug/agent><drugs abused><drugs of abuse><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><fewer symptoms><heavy metal Pb><heavy metal lead><hyperalgia><improved><in vivo><kappa opiate><kappa opioid><kappa opioid receptors><mental><mental illness><monoamine><mu opioid receptors><neurochemical><neurochemistry><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><observational research study><observational survey><opiate use disorder><opioid use disorder><patient safety><pharmacologic><pharmacophore><post-trauma stress disorder><posttrauma stress disorder><programs><prototype><psychiatric illness><psychological disorder><receptor><reduce symptoms><relieves symptoms><sedation><side effect><skeletons><substance use and disorder><symptom alleviation><symptom reduction><symptom relief><traumatic brain damage><traumatic neurosis><validations><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR><μ opioid receptors><μ-OR><μOR>

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Jeffrey Aube

UNIVERSITY OF SOUTH FLORIDA, TAMPA, FL

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$723,119

FY 2026

Project Title

Novel Probes of the Kappa Opioid Receptor: Chemistry, Pharmacology, and Biology

Grant Number:

7R01DA031927-12

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2011

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary We propose to develop new kappa opioid receptor (KOR) agonists that have diverse signaling profiles with the goal of correlating cellular signaling properties to favorable properties (antipruritic, anxiolytic and non-sedating) in mice. The KOR is an attractive drug target because dru...

Research Terms

<3'5'-cyclic ester of AMP><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adverse effects><Affect><Affective Disorders><Affinity><Agonist><Anti-Anxiety Agents><Anti-Anxiety Drugs><Anxiety><Anxiolytic Agents><Anxiolytics><Assay><Attributes of Chemicals><Azoles><Behavior><Behavioral><Binding><Bioassay><Biological Assay><Biology><Body Tissues><Brain><Brain Nervous System><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cells><Chemicals><Chemistry><Chlorochin><Chloroquine><Chronic><Clinical><Clinical Trials><Collection><Common Rat Strains><Complex><Corpus Striatum><Corpus striatum structure><Cryo-electron Microscopy><Cryoelectron Microscopy><Cyclic AMP><Darkness><Development><Dihydrohydroxycodeinone><Diuresis><Docking><Dopamine><Drug Kinetics><Drug Targeting><Drug abuse><Drugs><ERK 1><ERK1><ERK1 Kinase><Electron Cryomicroscopy><Encephalon><Extracellular Signal-Regulated Kinase 1><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><G-Proteins><GPCR><GTP-Binding Proteins><GTP-Regulatory Proteins><Goals><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><Hemodialyses><Hemodialysis><Human><Hydroxytyramine><Hyperactivity><In Vitro><In vivo analysis><Infumorph><Intermediary Metabolism><Intracellular Communication and Signaling><Investigators><Itching><KO mice><Kadian><Khingamin><Knock-out Mice><Knockout Mice><Ligands><Light><Locomotor Activity><MAP Kinase 3><MAPK3><MAPK3 Mitogen-Activated Protein Kinase><MAPK3 gene><MS Contin><MSir><Measures><Mediating><Medication><Medicine><Mental Depression><Metabolic Processes><Metabolism><Mice><Mice Mammals><Minor Tranquilizing Agents><Mitogen-Activated Protein Kinase 3><Mitogen-Activated Protein Kinase 3 Gene><Modeling><Modern Man><Molecular><Molecular Interaction><Mood Disorders><Morphia><Morphine><Motor Activity><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurologic><Neurologic Process><Neurological><Neurons><Nociception><Null Mouse><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid agonist><Opioid receptor agonist><Oramorph><Oramorph SR><Overdose><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><P44ERK1><PSTkinase p44mpk><Pain><Painful><Pharmaceutical Preparations><Pharmacokinetics><Pharmacology><Phosphates><Phosphorylation><Photoradiation><Physiologic><Physiological><Property><Protein Phosphorylation><Pruritic Disorder><Pruritis><Pruritus><Rat><Rats Mammals><Rattus><Receptor Activation><Receptor Protein><Receptor Signaling><Research Personnel><Researchers><Rodent><Rodentia><Rodents Mammals><Roxanol><Roxicodone><Sedation procedure><Signal Induction><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Statex SR><Strains Cell Lines><Striate Body><Striatum><Structural Biologist><Structure><Structure-Activity Relationship><Testing><Therapeutic><Therapeutic Effect><Time><Tissues><Transfection><Translating><Treatment Efficacy><Work><abuse of drugs><abuses drugs><addiction><addictive disorder><adenosine 3'5' monophosphate><anti-depressant agent><anti-depressant drugs><anti-depressants><anti-depressive agents><antinociception><antinociceptive><behavioral pharmacology><biological signal transduction><brain tissue><cAMP><chemical structure function><chemical synthesis><cryo-EM><cryoEM><cryogenic electron microscopy><cultured cell line><depression><developmental><drug action><drug/agent><dysphoria><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><improved><in vivo><in vivo evaluation><in vivo testing><induced human pluripotent stem cells><innovate><innovation><innovative><inorganic phosphate><interdisciplinary approach><intervention efficacy><itch sensation><kappa opiate><kappa opioid><kappa opioid receptors><mouse model><multidisciplinary approach><murine model><neuronal><nociceptive><non-human primate><nonhuman primate><novel><opiate use disorder><opioid use disorder><oxycodone self-administration><p44 MAPK><pain relief><pharmacobehavioral><pharmacologic><pharmacophore><pre-clinical><preclinical><preservation><programs><receptor><receptor internalization><recruit><relieve pain><response><scaffold><scaffolding><sedation><self-administer oxycodone><side effect><striatal><structure function relationship><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy><tool><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR>

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Laura M. Bohn

UNIVERSITY OF SOUTH FLORIDA, TAMPA, FL

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$723,119

FY 2026

Project Title

Novel Probes of the Kappa Opioid Receptor: Chemistry, Pharmacology, and Biology

Grant Number:

7R01DA031927-12

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2011

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary We propose to develop new kappa opioid receptor (KOR) agonists that have diverse signaling profiles with the goal of correlating cellular signaling properties to favorable properties (antipruritic, anxiolytic and non-sedating) in mice. The KOR is an attractive drug target because dru...

Research Terms

<3'5'-cyclic ester of AMP><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adverse effects><Affect><Affective Disorders><Affinity><Agonist><Anti-Anxiety Agents><Anti-Anxiety Drugs><Anxiety><Anxiolytic Agents><Anxiolytics><Assay><Attributes of Chemicals><Azoles><Behavior><Behavioral><Binding><Bioassay><Biological Assay><Biology><Body Tissues><Brain><Brain Nervous System><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cells><Chemicals><Chemistry><Chlorochin><Chloroquine><Chronic><Clinical><Clinical Trials><Collection><Common Rat Strains><Complex><Corpus Striatum><Corpus striatum structure><Cryo-electron Microscopy><Cryoelectron Microscopy><Cyclic AMP><Darkness><Development><Dihydrohydroxycodeinone><Diuresis><Docking><Dopamine><Drug Kinetics><Drug Targeting><Drug abuse><Drugs><ERK 1><ERK1><ERK1 Kinase><Electron Cryomicroscopy><Encephalon><Extracellular Signal-Regulated Kinase 1><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><G-Proteins><GPCR><GTP-Binding Proteins><GTP-Regulatory Proteins><Goals><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><Hemodialyses><Hemodialysis><Human><Hydroxytyramine><Hyperactivity><In Vitro><In vivo analysis><Infumorph><Intermediary Metabolism><Intracellular Communication and Signaling><Investigators><Itching><KO mice><Kadian><Khingamin><Knock-out Mice><Knockout Mice><Ligands><Light><Locomotor Activity><MAP Kinase 3><MAPK3><MAPK3 Mitogen-Activated Protein Kinase><MAPK3 gene><MS Contin><MSir><Measures><Mediating><Medication><Medicine><Mental Depression><Metabolic Processes><Metabolism><Mice><Mice Mammals><Minor Tranquilizing Agents><Mitogen-Activated Protein Kinase 3><Mitogen-Activated Protein Kinase 3 Gene><Modeling><Modern Man><Molecular><Molecular Interaction><Mood Disorders><Morphia><Morphine><Motor Activity><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurologic><Neurologic Process><Neurological><Neurons><Nociception><Null Mouse><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid agonist><Opioid receptor agonist><Oramorph><Oramorph SR><Overdose><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><P44ERK1><PSTkinase p44mpk><Pain><Painful><Pharmaceutical Preparations><Pharmacokinetics><Pharmacology><Phosphates><Phosphorylation><Photoradiation><Physiologic><Physiological><Property><Protein Phosphorylation><Pruritic Disorder><Pruritis><Pruritus><Rat><Rats Mammals><Rattus><Receptor Activation><Receptor Protein><Receptor Signaling><Research Personnel><Researchers><Rodent><Rodentia><Rodents Mammals><Roxanol><Roxicodone><Sedation procedure><Signal Induction><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Statex SR><Strains Cell Lines><Striate Body><Striatum><Structural Biologist><Structure><Structure-Activity Relationship><Testing><Therapeutic><Therapeutic Effect><Time><Tissues><Transfection><Translating><Treatment Efficacy><Work><abuse of drugs><abuses drugs><addiction><addictive disorder><adenosine 3'5' monophosphate><anti-depressant agent><anti-depressant drugs><anti-depressants><anti-depressive agents><antinociception><antinociceptive><behavioral pharmacology><biological signal transduction><brain tissue><cAMP><chemical structure function><chemical synthesis><cryo-EM><cryoEM><cryogenic electron microscopy><cultured cell line><depression><developmental><drug action><drug/agent><dysphoria><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><improved><in vivo><in vivo evaluation><in vivo testing><induced human pluripotent stem cells><innovate><innovation><innovative><inorganic phosphate><interdisciplinary approach><intervention efficacy><itch sensation><kappa opiate><kappa opioid><kappa opioid receptors><mouse model><multidisciplinary approach><murine model><neuronal><nociceptive><non-human primate><nonhuman primate><novel><opiate use disorder><opioid use disorder><oxycodone self-administration><p44 MAPK><pain relief><pharmacobehavioral><pharmacologic><pharmacophore><pre-clinical><preclinical><preservation><programs><receptor><receptor internalization><recruit><relieve pain><response><scaffold><scaffolding><sedation><self-administer oxycodone><side effect><striatal><structure function relationship><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy><tool><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR>

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Alessandro Stevens De Nadai

MCLEAN HOSPITAL, BELMONT, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$714,786

FY 2026

Project Title

Impact of prescription stimulants on the drug overdose epidemic

Grant Number:

5R01DA058315-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT The use of prescription stimulants in adults has increased dramatically, with a five-fold increase in use of amphetamines between 2004 and 2019. Coinciding with increased prescribing of stimulants, there has been an acceleration of fatal overdoses involving illicit psychostimulants. During...

Research Terms

<21+ years old><Abstinence><Acceleration><Accident and Emergency department><Actiq><Active Follow-up><Adherence><Adult><Adult Human><Adverse Experience><Adverse event><Amphetamines><Benefits and Risks><Benzodiazepine Compounds><Benzodiazepines><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cessation of life><Characteristics><Clinical><Cocaine><Cocaine use disorder><Cohort Studies><Complement 3><Complement Component 3><Complex><Control Groups><Crystal Meth><Crystal methamphetamine><Dangerousness><Data><Data Bases><Data Set><Data Sources><Databases><Death><Death Certificates><Deoxyephedrine><Desoxyephedrine><Desoxynorephedrin><Diacetylmorphine><Diamorphine><Dose><Drug abuse><Drugs><Duragesic><ED visit><ER visit><Early Intervention><Educational Activities><Emergency Department><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency medical service><Emergency room><Emergency room visit><Epidemic><Fentanest><Fentanyl><Fentyl><Future><Goals><Guidelines><Heroin><Heterogeneity><History><Hospitals><Individual><Inpatients><Interdisciplinary Research><Interdisciplinary Study><Internet><Knowledge><Link><Long-term Follow-up><Massachusetts><Medication><Methamphetamine><Methamphetamine use disorder><Methods><Methylamphetamine><Modeling><Multidisciplinary Collaboration><Multidisciplinary Research><N-Methylamphetamine><NIDA><NIH Program Announcements><National Institute of Drug Abuse><National Institute on Drug Abuse><Observational Study><Opiates><Opioid><Oregon><Outcome><Overdose><Overdose reduction><Patients><Pattern><Pharmaceutical Preparations><Pharmacies><Pharmacy facility><Phase><Phenamine><Phenopromin><Phentanyl><Policies><Prescription Drug Monitoring Program><Program Announcement><Provider><Public Health><Recording of previous events><Records><Research><Risk><Risk Assessment><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sample Size><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Stimulant><Stimulant overdose><Substance Use Disorder><Therapeutic><Time><Toxicology><Translating><United States><Update><WWW><Work><abuse of drugs><abuses drugs><active followup><adulthood><amphetamine use><case control><case-controlled><cohort research study><cohort survey><continuing medical education><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><data base><data collected in real world><design><designing><dl-Amphetamine><drug/agent><emergency service><evidence base><fentanyl contamination><follow up><follow-up><followed up><followup><heroin intake><heroin use><high risk><histories><innovate><innovation><innovative><licit opioid><long-term followup><medication for opioid use disorder><meth><meth use disorder><multiple substance use><multisubstance use><novel><observational research study><observational survey><opiate consumption><opiate crisis><opiate drug use><opiate intake><opiate medication><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid crisis><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><overdose death><overdose fatalities><overdose risk><pill><poly substance use><polysubstance use><prescribed opiate><prescribed opioid><prescription monitoring program><prescription opiate><prescription opioid><prescription stimulants><prevent><preventing><protective effect><psychostimulant><psychostimulant overdose><psychostimulant use><psychostimulant use disorder><randomized placebo control trial><randomized placebo controlled trial><real world data><real world evidence><reduce overdose><reduction in overdose><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social role><stimulant use><stimulant use disorder><substance abuse therapy><substance abuse treatment><substance use and disorder><substance use treatment><telehealth care><telehealthcare><use of stimulants><web><world wide web>

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Susan L Calcaterra

UNIVERSITY OF COLORADO DENVER, Aurora, CO

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$709,085

FY 2026

Project Title

Facilitating In-Hospital Opioid Treatment Program Intakes to Support Hospital to OTP Linkage among Hospitalized Patients with Opioid Use Disorder: An Implementation Trial in Four Hospitals

Grant Number:

1R01DA063733-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY / ABSTRACT Methadone is a highly effective medication for opioid use disorder (OUD) treatment. When taken regularly, it is associated with a 50% mortality reduction. Unfortunately, less than 5% of the estimated 7.6 million individuals with OUD receive methadone treatment. Hospitaliza...

Research Terms

<21+ years old><Adanon><Adoption><Adult><Adult Human><Agreement><Althose><Application Context><Assess implementation><Caring><Cessation of life><Characteristics><Clinical><Collection><Consultations><Data><Death><Documentation><Dolophine><Effectiveness><Electronic Health Record><Enrollment><Ensure><Evaluation><Feedback><Focus Groups><Goals><Hospital Admission><Hospitalization><Hospitals><Hybrids><Implementation assessment><Individual><Intake><Learning><Life><Link><Maintenance><Measurement><Measures><Medical><Medical Directors><Medicine><Mental Health><Mental Hygiene><Methadone><Methadose><Modification><Monitor><On-Line Systems><Online Systems><Out-patients><Outpatients><Overdose><PRISM framework><PRISM model><Patients><Performance><Persons><Phase><Physician Executives><Practical Robust Implementation and Sustainability Model><Pragmatic, Robust Implementation and Sustainability Model><Process><Psychological Health><RE-AIM><Randomized><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Regulation><Relaxation><Reporting><Research Resources><Resources><Series><Services><Site><Site Visit><Survey Instrument><Surveys><Time><Transportation><Vulnerable Populations><access to transportation><acute care><addiction><addictive disorder><adulthood><care as usual><clinical care><clinical practice><cluster randomized design><consultation><contextual factors><cost><effectiveness measure><effectiveness outcome><effectiveness testing><effectiveness-related outcomes><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><enroll><evaluate implementation><evaluation of implementation><evidence base><formative assessment><formative evaluation><hospital care><implementation cost><implementation evaluation><implementation facilitation><implementation fidelity><implementation investment><implementation measures><implementation outcomes><implementation science><implementation trial><improved><medication for opioid use disorder><meeting><meetings><member><methadone maintenance><methadone maintenance program><methadone maintenance therapy><methadone maintenance treatment><methadone treatment><mortality><mutual learning><novel><online computer><opiate use disorder><opiate withdrawal><opioid detox><opioid detoxification><opioid treatment program><opioid use disorder><opioid withdrawal><overdose death><overdose fatalities><post implementation><randomisation><randomization><randomly assigned><reach, efficacy, adoption, implementation, and maintenance><screening><screenings><secondary outcome><social stigma><stigma><sustained recovery><transportation access><treatment as usual><treatment program><treatment site><uptake><usual care><vulnerable group><vulnerable individual><vulnerable people><web based>

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Patience Moyo Dow

BROWN UNIVERSITY, PROVIDENCE, RI

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$708,233

FY 2026

Project Title

Impact of Medicaid Prescription Cap Policies on Treatment Outcomes for Opioid Use Disorder: A National Mixed Methods Study

Grant Number:

5R01DA057979-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY More than 2 million people have opioid use disorder (OUD) in the U.S. and opioids accounted for 70% of the nearly 100,000 drug-overdose deaths in 2020. Increasing OUD prevalence and opioid-involved overdose deaths underscore the urgent need for improved access to effective OUD treatm...

Research Terms

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Jaclyn White Hughto

BROWN UNIVERSITY, PROVIDENCE, RI

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$708,233

FY 2026

Project Title

Impact of Medicaid Prescription Cap Policies on Treatment Outcomes for Opioid Use Disorder: A National Mixed Methods Study

Grant Number:

5R01DA057979-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY More than 2 million people have opioid use disorder (OUD) in the U.S. and opioids accounted for 70% of the nearly 100,000 drug-overdose deaths in 2020. Increasing OUD prevalence and opioid-involved overdose deaths underscore the urgent need for improved access to effective OUD treatm...

Research Terms

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Alene Kennedy Hendricks

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$676,008

FY 2026

Project Title

Establishing an Evidence Base to Increase the Utility of Urine Drug Testing in Opioid Use Disorder Treatment.

Grant Number:

5R01DA059528-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Urine drug testing (UDT) is an integral component of opioid use disorder (OUD) treatment, and is often required by payers for patients treated with medications for OUD (MOUD). These regulations exist despite a lack of evidence-based guidelines. There is no consensus about th...

Research Terms

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BRENDAN K SALONER

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$676,008

FY 2026

Project Title

Establishing an Evidence Base to Increase the Utility of Urine Drug Testing in Opioid Use Disorder Treatment.

Grant Number:

5R01DA059528-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Urine drug testing (UDT) is an integral component of opioid use disorder (OUD) treatment, and is often required by payers for patients treated with medications for OUD (MOUD). These regulations exist despite a lack of evidence-based guidelines. There is no consensus about th...

Research Terms

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Kurt F Hauser

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$661,789

FY 2026

Project Title

Opioid and non-opioid receptor mechanisms in neurons and glia underlying fentanyl and HIV comorbidity in the striatum

Grant Number:

5R01DA060724-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Fentanyl and its analogues are increasingly responsible for drug overdose deaths in the United States and worldwide. As a potent µ-opioid receptor (MOR) agonist, fentanyl is anticipated to exacerbate the pathobiology of neuroHIV and HIV-associated neurocognitive disorder (HAND) via complex mechanism...

Research Terms

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Viktor Yarotskyy

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$661,789

FY 2026

Project Title

Opioid and non-opioid receptor mechanisms in neurons and glia underlying fentanyl and HIV comorbidity in the striatum

Grant Number:

5R01DA060724-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Fentanyl and its analogues are increasingly responsible for drug overdose deaths in the United States and worldwide. As a potent µ-opioid receptor (MOR) agonist, fentanyl is anticipated to exacerbate the pathobiology of neuroHIV and HIV-associated neurocognitive disorder (HAND) via complex mechanism...

Research Terms

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Cici Bauer

TUFTS UNIVERSITY BOSTON, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$659,368

FY 2026

Project Title

Predict to Prevent: Dynamic Spatiotemporal Analyses of Opioid Overdose to Guide Pre-Emptive Public Health Responses

Grant Number:

5R01DA054267-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Predict to Prevent: Dynamic Spatiotemporal Analyses of Opioid Overdose to Guide Pre-Emptive Public Health Responses PROJECT SUMMARY/ABSTRACT Opioid overdose (OD) fatalities have reached crisis levels in all socioeconomic and geographic communities in the US. By utilizing a first-of-its-kind statew...

Research Terms

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Thomas J Stopka

TUFTS UNIVERSITY BOSTON, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$659,368

FY 2026

Project Title

Predict to Prevent: Dynamic Spatiotemporal Analyses of Opioid Overdose to Guide Pre-Emptive Public Health Responses

Grant Number:

5R01DA054267-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Predict to Prevent: Dynamic Spatiotemporal Analyses of Opioid Overdose to Guide Pre-Emptive Public Health Responses PROJECT SUMMARY/ABSTRACT Opioid overdose (OD) fatalities have reached crisis levels in all socioeconomic and geographic communities in the US. By utilizing a first-of-its-kind statew...

Research Terms

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Meaghan C Creed

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$618,757

FY 2026

Project Title

Dissecting ventral pallidal plasticity in punishment-resistant opioid self-administration

Grant Number:

5R01DA058755-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Opioid use disorder (OUD) is an escalating public health concern, and has resulted in over 550,000 overdose deaths between 1999 and 2020. Specifically, initial exposure to prescription opioids, such as oxycodone (OXY), has contributed to an average of 13,850 deaths annually since 201...

Research Terms

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Ryan W Logan

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$570,649

FY 2026

Project Title

Discovery and functional characterization of long non-coding RNAs in opioid use disorder within the context of HIV at single cell resolution

Grant Number:

5R01DA063146-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Opioid use disorder (OUD) is a significant public health threat that affects millions of people and is associated with high rates of co-occurring conditions such as HIV. Approximately 17% of the 15 million people who inject drugs globally are HIV-positive. Conversely, HIV-positive individua...

Research Terms

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Chan Zhou

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$570,649

FY 2026

Project Title

Discovery and functional characterization of long non-coding RNAs in opioid use disorder within the context of HIV at single cell resolution

Grant Number:

5R01DA063146-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Opioid use disorder (OUD) is a significant public health threat that affects millions of people and is associated with high rates of co-occurring conditions such as HIV. Approximately 17% of the 15 million people who inject drugs globally are HIV-positive. Conversely, HIV-positive individua...

Research Terms

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JASON T BLACKARD

UNIVERSITY OF CINCINNATI, CINCINNATI, OH

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$549,599

FY 2026

Project Title

Single cell opioid (fentanyl) responses in the context of HIV

Grant Number:

5R01DA063296-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract The number of drug overdose deaths has increased significantly in recent years. By 2019, 70.6% of drug overdose deaths involved opioids, and in Ohio, >90% of unintentional overdose deaths involved fentanyl. Opioid receptors are expressed in multiple peripheral blood mononuclear cell (PBMC) ...

Research Terms

<21+ years old><AIDS Virus><AIDS focused research><AIDS related research><AIDS research><AIDS science><AIDS specific research><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Actiq><Adult><Adult Human><Affect><Age><Alcohol Chemical Class><Alcohols><Anti-HIV Positivity><Apoptosis><Apoptosis Pathway><Area><Atlases><B-Cells><B-Lymphocytes><B-cell><Bioinformatics><Blood Cells><Blood Sample><Blood monocyte><Blood specimen><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell-to-Cell Interaction><Cells><Chemotactic Cytokines><Cocaine><Communities><Crystal Meth><Crystal methamphetamine><Cytotoxic cell><Data><Dendritic Cells><Deoxyephedrine><Desoxyephedrine><Diacetylmorphine><Diamorphine><Drug Prescribing><Drug Prescriptions><Drug usage><Drugs><Duragesic><Enrollment><Fatality rate><Fentanest><Fentanyl><Fentyl><Funding><Gene Expression><Genes><HCV><HCV infection><HIV><HIV Infections><HIV Positive><HIV Positivity><HIV Seroconversion><HIV Seropositivity><HIV antibody positive><HIV diagnosis><HIV disease><HIV focused research><HIV individuals><HIV infected individuals><HIV infected persons><HIV investigation><HIV people><HIV positive individuals><HIV positive people><HIV related research><HIV replication><HIV research><HIV science><HIV specific research><HIV viral infection><HIV viral replication><HIV virus infection><HIV+><HIV-1 disease><HIV-1 infection><HIV-1 replication><HIV-1 viral replication><HIV-1 virus replication><HIV/AIDS disease><HTLV-III Seroconversion><HTLV-III Seropositivity><Hepatitis C virus><Hepatitis C virus infection><Hepatocarcinogenesis><Heroin><Homologous Chemotactic Cytokines><Human Immunodeficiency Viruses><IFN><Immune><Immunes><In Vitro><Infection><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Injecting drug user><Injection Drug User><Innate Immune Response><Intercrines><Interferon Type I><Interferons><Intracellular Communication and Signaling><Investigation on HIV><K lymphocyte><LAV-HTLV-III><Liquid Chromatography><Liver Carcinogenesis><Location><Lymphadenopathy-Associated Virus><Macrophage><Marrow monocyte><Mediating><Medication><Medicine><Methamphetamine><Methylamphetamine><MicroRNAs><Modeling><Morbidity><Mφ><N-Methylamphetamine><NIDA><NK Cells><National Institute of Drug Abuse><National Institute on Drug Abuse><Natural Killer Cells><Ohio><Opiate Receptors><Opiates><Opioid><Opioid Receptor><Overdose><PBMC><PLWH><PWH><PWID><Participant><Pathogenesis><Pathology><Pathway interactions><Patients><Peripheral><Peripheral Blood Cell><Peripheral Blood Mononuclear Cell><Pharmaceutical Preparations><Phentanyl><Population><Predisposition><Programmed Cell Death><RT-PCR><Recreation><Research><Reverse Transcriptase Polymerase Chain Reaction><Risk><SIS cytokines><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Susceptibility><T4 Cells><T4 Lymphocytes><T8 Cells><T8 Lymphocytes><Time><Translational Research><Translational Science><Universities><Validation><Veiled Cells><Viral><Viral Diseases><Viral Genes><Virus><Virus Diseases><Virus-HIV><abused drug><abused drugs><addiction><addictive disorder><adulthood><ages><biological signal transduction><carcinogenesis in the liver><cell type><chemoattractant cytokine><chemokine><cohort><college><collegiate><cytokine><differential expression><differentially expressed><drug abused><drug of abuse><drug use><drug/agent><drugs abused><drugs of abuse><enroll><experiment><experimental research><experimental study><experiments><fentalogs><fentalogues><fentanyl analog><fentanyl use><global gene expression><global transcription profile><hepatic carcinogenesis><hepatitis C infection><hepatocellular carcinogenesis><human immunodeficiency virus disease><human immunodeficiency virus infection><human immunodeficiency virus replication><human immunodeficiency virus research><human immunodeficiency virus-1 replication><in vivo><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HCV><infected with HIV><infected with hepatitis C><infected with hepatitis C virus><infected with human immunodeficiency virus><infection by hepatitis c virus><infection with HCV><infection with hepatitis C><infection with hepatitis C virus><injection drug use><liver cancer pathogenesis><liver tumorigenesis><medication prescription><meth><miRNA><monocyte><mortality><multiomics><multiple omics><novel><opiate consumption><opiate crisis><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opioid consumption><opioid crisis><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><overdose death><overdose fatalities><panomics><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people who inject drugs><people who inject illicit drugs><people with HIV><people with human immunodeficiency virus><peripheral blood><persons who inject drugs><prescribed medication><receptor expression><research addressing HIV><research in HIV><research into HIV><research on HIV><research on human immunodeficiency virus><research to address HIV><response><reverse transcriptase PCR><scRNA sequencing><scRNA-seq><science on HIV><science to address HIV><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><studies on HIV><synthetic opiate><synthetic opioid><tandem mass spectrometry><therapy optimization><transcriptional differences><transcriptome><translation research><translational investigation><treatment optimization><validations><viral infection><virus infection><virus-induced disease>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jerod S. Denton

UNIVERSITY OF NEBRASKA MEDICAL CENTER, OMAHA, NE

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$546,237

FY 2026

Project Title

Discovery and characterization of selective GIRK1/2 activators and their evaluation in preclinical models of pain

Grant Number:

5R01NS127439-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: Chronic pain is a poorly managed health disorder and common treatments (e.g. opioids) have significant issues associated with them: risk of addiction, constipation, cognitive impairment, motor impairment, fatal respiratory depression, and others. Developing new, non-opioid based pai...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Corey R. Hopkins

UNIVERSITY OF NEBRASKA MEDICAL CENTER, OMAHA, NE

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$546,237

FY 2026

Project Title

Discovery and characterization of selective GIRK1/2 activators and their evaluation in preclinical models of pain

Grant Number:

5R01NS127439-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: Chronic pain is a poorly managed health disorder and common treatments (e.g. opioids) have significant issues associated with them: risk of addiction, constipation, cognitive impairment, motor impairment, fatal respiratory depression, and others. Developing new, non-opioid based pai...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Xinmin Simon Xie

UNIVERSITY OF NEBRASKA MEDICAL CENTER, OMAHA, NE

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$546,237

FY 2026

Project Title

Discovery and characterization of selective GIRK1/2 activators and their evaluation in preclinical models of pain

Grant Number:

5R01NS127439-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: Chronic pain is a poorly managed health disorder and common treatments (e.g. opioids) have significant issues associated with them: risk of addiction, constipation, cognitive impairment, motor impairment, fatal respiratory depression, and others. Developing new, non-opioid based pai...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Mark Bender Gerstein

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$526,616

FY 2026

Project Title

Team Science for MultiScale Data Mining and Functional Validation of Single-Cell Opioid Responses in the Context of HIV

Grant Number:

5R01DA063316-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

With approximately 296 million people (5.8% of the global population aged 15–64) having used drugs at least once, the world is facing an unprecedented opioid epidemic. Chronic opioid exposure can lead to long-term brain function changes and opioid use disorder (OUD). Concurrently, despite advancemen...

Research Terms

<15 year old><15 years of age><3-D><3-Dimensional><3D><AI based method><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Affect><Assay><Atlases><Basal Transcription Factor><Basal transcription factor genes><Behavior><Benchmarking><Best Practice Analysis><Bioassay><Biological Assay><Brain><Brain Nervous System><CNS Nervous System><CNS plasticity><CRISPR><CRISPR/Cas system><Cell Body><Cell Communication><Cell Interaction><Cell Nucleus><Cell to Cell Communication and Signaling><Cell-Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Immune Function><Central Nervous System><Chromatin><Chronic><Chronic Disease><Chronic Illness><Clustered Regularly Interspaced Short Palindromic Repeats><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><Data><Development><Differential Gene Expression><Disturbance in cognition><Drop-seq><Drug usage><Dysfunction><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exhibits><Exposure to><Functional disorder><Funding><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genetic Transcription><Genomics><Goals><HIV><HIV Infections><HIV individuals><HIV infected individuals><HIV infected persons><HIV infection persistence><HIV people><HIV persistence><HIV positive individuals><HIV positive people><HIV viral infection><HIV viral persistence><HIV virus infection><HIV-1 infection><HIV-1 persistence><High Throughput Assay><Human><Human Immunodeficiency Viruses><Impaired cognition><Impairment><Individual><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><LAV-HTLV-III><Ligands><Linkage Disequilibrium><Long-term infection><Lymphadenopathy-Associated Virus><Maps><Measures><Methods><Modality><Modern Man><Molecular><Molecular Configuration><Molecular Conformation><Molecular Fingerprinting><Molecular Profiling><Molecular Stereochemistry><Moods><Nerve Transmitter Substances><Network-based><Neuraxis><Neuronal Plasticity><Neurotransmitters><Nucleus><Opiate Receptors><Opiates><Opioid><Opioid Receptor><PLWH><PWH><Pathway interactions><Performance><Persons><Phenotype><Physiopathology><Play><Population><Publishing><RNA Expression><Receptor Gene><Regulatory Element><Reporter><Reporting><Resolution><Rewards><Role><Sampling><Science><Single-Nucleus Sequencing><Stimulus><System><Technology><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Transcript><Transcription><Transcription Factor Proto-Oncogene><Transcription Process><Transcription factor genes><Translations><Validation><Venus><Virus-HIV><abnormal brain function><age 15><age 15 years><artificial intelligence method><benchmark><brain cell><brain dysfunction><brain impairment><cell type><central nervous system plasticity><chronic disorder><chronic infection><cognitive dysfunction><cognitive function><cognitive loss><conformation><conformational><conformational state><conformationally><conformations><data mining><datamining><developmental><differential expression><differentially expressed><driving force><droplet sequencing><drug craving><drug use><dysfunctional brain><epigenetically><experiment><experimental research><experimental study><experiments><fifteen year old><fifteen years of age><gene regulatory network><graph attention network><graph convolutional network><graph neural network><high risk><high throughput screening><human immunodeficiency virus infection><human immunodeficiency virus persistence><iPS><iPSC><iPSCs><immune function><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infected with HIV><infected with human immunodeficiency virus><intercellular communication><knock-down><knockdown><machine learning based method><machine learning method><machine learning methodologies><molecular profile><molecular scale><molecular signature><multi-scale data><multiscale data><neural plasticity><neuroplastic><neuroplasticity><opiate consumption><opiate crisis><opiate drug use><opiate exposure><opiate intake><opiate use><opiate use disorder><opioid consumption><opioid crisis><opioid drug use><opioid epidemic><opioid exposure><opioid intake><opioid use><opioid use disorder><pathophysiology><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><persistent HIV><persistent HIV-1><persistent human immunodeficiency virus><persistent infection><resolutions><response><sNuc-Seq><simulation><single cell genomics><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><substance use><substance using><therapeutically effective><three dimensional><tool><transcription factor><transcriptional differences><transcriptomics><translation><translation strategy><translational approach><translational strategy><validations>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

HYEJUNG WON

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$526,616

FY 2026

Project Title

Team Science for MultiScale Data Mining and Functional Validation of Single-Cell Opioid Responses in the Context of HIV

Grant Number:

5R01DA063316-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

With approximately 296 million people (5.8% of the global population aged 15–64) having used drugs at least once, the world is facing an unprecedented opioid epidemic. Chronic opioid exposure can lead to long-term brain function changes and opioid use disorder (OUD). Concurrently, despite advancemen...

Research Terms

<15 year old><15 years of age><3-D><3-Dimensional><3D><AI based method><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Affect><Assay><Atlases><Basal Transcription Factor><Basal transcription factor genes><Behavior><Benchmarking><Best Practice Analysis><Bioassay><Biological Assay><Brain><Brain Nervous System><CNS Nervous System><CNS plasticity><CRISPR><CRISPR/Cas system><Cell Body><Cell Communication><Cell Interaction><Cell Nucleus><Cell to Cell Communication and Signaling><Cell-Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Immune Function><Central Nervous System><Chromatin><Chronic><Chronic Disease><Chronic Illness><Clustered Regularly Interspaced Short Palindromic Repeats><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><Data><Development><Differential Gene Expression><Disturbance in cognition><Drop-seq><Drug usage><Dysfunction><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exhibits><Exposure to><Functional disorder><Funding><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genetic Transcription><Genomics><Goals><HIV><HIV Infections><HIV individuals><HIV infected individuals><HIV infected persons><HIV infection persistence><HIV people><HIV persistence><HIV positive individuals><HIV positive people><HIV viral infection><HIV viral persistence><HIV virus infection><HIV-1 infection><HIV-1 persistence><High Throughput Assay><Human><Human Immunodeficiency Viruses><Impaired cognition><Impairment><Individual><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><LAV-HTLV-III><Ligands><Linkage Disequilibrium><Long-term infection><Lymphadenopathy-Associated Virus><Maps><Measures><Methods><Modality><Modern Man><Molecular><Molecular Configuration><Molecular Conformation><Molecular Fingerprinting><Molecular Profiling><Molecular Stereochemistry><Moods><Nerve Transmitter Substances><Network-based><Neuraxis><Neuronal Plasticity><Neurotransmitters><Nucleus><Opiate Receptors><Opiates><Opioid><Opioid Receptor><PLWH><PWH><Pathway interactions><Performance><Persons><Phenotype><Physiopathology><Play><Population><Publishing><RNA Expression><Receptor Gene><Regulatory Element><Reporter><Reporting><Resolution><Rewards><Role><Sampling><Science><Single-Nucleus Sequencing><Stimulus><System><Technology><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Transcript><Transcription><Transcription Factor Proto-Oncogene><Transcription Process><Transcription factor genes><Translations><Validation><Venus><Virus-HIV><abnormal brain function><age 15><age 15 years><artificial intelligence method><benchmark><brain cell><brain dysfunction><brain impairment><cell type><central nervous system plasticity><chronic disorder><chronic infection><cognitive dysfunction><cognitive function><cognitive loss><conformation><conformational><conformational state><conformationally><conformations><data mining><datamining><developmental><differential expression><differentially expressed><driving force><droplet sequencing><drug craving><drug use><dysfunctional brain><epigenetically><experiment><experimental research><experimental study><experiments><fifteen year old><fifteen years of age><gene regulatory network><graph attention network><graph convolutional network><graph neural network><high risk><high throughput screening><human immunodeficiency virus infection><human immunodeficiency virus persistence><iPS><iPSC><iPSCs><immune function><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infected with HIV><infected with human immunodeficiency virus><intercellular communication><knock-down><knockdown><machine learning based method><machine learning method><machine learning methodologies><molecular profile><molecular scale><molecular signature><multi-scale data><multiscale data><neural plasticity><neuroplastic><neuroplasticity><opiate consumption><opiate crisis><opiate drug use><opiate exposure><opiate intake><opiate use><opiate use disorder><opioid consumption><opioid crisis><opioid drug use><opioid epidemic><opioid exposure><opioid intake><opioid use><opioid use disorder><pathophysiology><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><persistent HIV><persistent HIV-1><persistent human immunodeficiency virus><persistent infection><resolutions><response><sNuc-Seq><simulation><single cell genomics><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><substance use><substance using><therapeutically effective><three dimensional><tool><transcription factor><transcriptional differences><transcriptomics><translation><translation strategy><translational approach><translational strategy><validations>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JING ZHANG

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$526,616

FY 2026

Project Title

Team Science for MultiScale Data Mining and Functional Validation of Single-Cell Opioid Responses in the Context of HIV

Grant Number:

5R01DA063316-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

With approximately 296 million people (5.8% of the global population aged 15–64) having used drugs at least once, the world is facing an unprecedented opioid epidemic. Chronic opioid exposure can lead to long-term brain function changes and opioid use disorder (OUD). Concurrently, despite advancemen...

Research Terms

<15 year old><15 years of age><3-D><3-Dimensional><3D><AI based method><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Affect><Assay><Atlases><Basal Transcription Factor><Basal transcription factor genes><Behavior><Benchmarking><Best Practice Analysis><Bioassay><Biological Assay><Brain><Brain Nervous System><CNS Nervous System><CNS plasticity><CRISPR><CRISPR/Cas system><Cell Body><Cell Communication><Cell Interaction><Cell Nucleus><Cell to Cell Communication and Signaling><Cell-Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Immune Function><Central Nervous System><Chromatin><Chronic><Chronic Disease><Chronic Illness><Clustered Regularly Interspaced Short Palindromic Repeats><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><Data><Development><Differential Gene Expression><Disturbance in cognition><Drop-seq><Drug usage><Dysfunction><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exhibits><Exposure to><Functional disorder><Funding><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genetic Transcription><Genomics><Goals><HIV><HIV Infections><HIV individuals><HIV infected individuals><HIV infected persons><HIV infection persistence><HIV people><HIV persistence><HIV positive individuals><HIV positive people><HIV viral infection><HIV viral persistence><HIV virus infection><HIV-1 infection><HIV-1 persistence><High Throughput Assay><Human><Human Immunodeficiency Viruses><Impaired cognition><Impairment><Individual><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><LAV-HTLV-III><Ligands><Linkage Disequilibrium><Long-term infection><Lymphadenopathy-Associated Virus><Maps><Measures><Methods><Modality><Modern Man><Molecular><Molecular Configuration><Molecular Conformation><Molecular Fingerprinting><Molecular Profiling><Molecular Stereochemistry><Moods><Nerve Transmitter Substances><Network-based><Neuraxis><Neuronal Plasticity><Neurotransmitters><Nucleus><Opiate Receptors><Opiates><Opioid><Opioid Receptor><PLWH><PWH><Pathway interactions><Performance><Persons><Phenotype><Physiopathology><Play><Population><Publishing><RNA Expression><Receptor Gene><Regulatory Element><Reporter><Reporting><Resolution><Rewards><Role><Sampling><Science><Single-Nucleus Sequencing><Stimulus><System><Technology><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Transcript><Transcription><Transcription Factor Proto-Oncogene><Transcription Process><Transcription factor genes><Translations><Validation><Venus><Virus-HIV><abnormal brain function><age 15><age 15 years><artificial intelligence method><benchmark><brain cell><brain dysfunction><brain impairment><cell type><central nervous system plasticity><chronic disorder><chronic infection><cognitive dysfunction><cognitive function><cognitive loss><conformation><conformational><conformational state><conformationally><conformations><data mining><datamining><developmental><differential expression><differentially expressed><driving force><droplet sequencing><drug craving><drug use><dysfunctional brain><epigenetically><experiment><experimental research><experimental study><experiments><fifteen year old><fifteen years of age><gene regulatory network><graph attention network><graph convolutional network><graph neural network><high risk><high throughput screening><human immunodeficiency virus infection><human immunodeficiency virus persistence><iPS><iPSC><iPSCs><immune function><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><infected with HIV><infected with human immunodeficiency virus><intercellular communication><knock-down><knockdown><machine learning based method><machine learning method><machine learning methodologies><molecular profile><molecular scale><molecular signature><multi-scale data><multiscale data><neural plasticity><neuroplastic><neuroplasticity><opiate consumption><opiate crisis><opiate drug use><opiate exposure><opiate intake><opiate use><opiate use disorder><opioid consumption><opioid crisis><opioid drug use><opioid epidemic><opioid exposure><opioid intake><opioid use><opioid use disorder><pathophysiology><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><persistent HIV><persistent HIV-1><persistent human immunodeficiency virus><persistent infection><resolutions><response><sNuc-Seq><simulation><single cell genomics><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><substance use><substance using><therapeutically effective><three dimensional><tool><transcription factor><transcriptional differences><transcriptomics><translation><translation strategy><translational approach><translational strategy><validations>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Schahram Akbarian

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$2,352,000

FY 2026

Project Title

Single molecule functional validation of neurogenomic alterations in opioid-exposed HIV brain

Grant Number:

1R01DA065015-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Neurogenomic studies by the SCORCH (Single Cell Opioid Response in the Context of HIV) consortium strongly suggest that brains of individuals living with HIV in the context of opioid or (polys)substance use disorder (OUD/SUD) comorbidity harbor a molecular environment permissive for HIV viral replic...

Research Terms

<30 nm Chromatin Fiber><30 nm Fiber><AIDS Virus><ATAC><ATAC sequencing><ATAC-seq><ATACseq><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Anterior><Anti-HIV Positivity><Anti-Retroviral Agents><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Astrocytes><Astrocytus><Astroglia><Autopsy><Basal Transcription Factor><Basal transcription factor genes><Base Pairing><Bioassay><Biological Assay><Brain><Brain Nervous System><CRISPR interference><CRISPR-dCas9-mediated repression><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Case-Comparison Studies><Case-Compeer Studies><Case-Referent Studies><Case-Referrent Studies><Case/Control Studies><Cell Body><Cell Culture Techniques><Cells><Chromatin><Chromatin Fiber><Clustered Regularly Interspaced Short Palindromic Repeats interference><DNA><Data><Deoxyribonucleic Acid><Disease><Disorder><Drugs><Encephalon><Enhancers><Environment><Exposure to><Fiber><Fostering><Frequencies><General Transcription Factor Gene><General Transcription Factors><Genes><Genomics><Goals><Grant><HIV><HIV Infections><HIV Positive><HIV Positivity><HIV Seroconversion><HIV Seropositivity><HIV antibody positive><HIV disease transmission><HIV in patients><HIV infection spread><HIV infection transmission><HIV patient><HIV positive patient><HIV replication><HIV spread><HIV transmission><HIV viral infection><HIV viral replication><HIV viral transmission><HIV virus infection><HIV+><HIV-1 infection><HIV-1 replication><HIV-1 spread><HIV-1 transmission><HIV-1 viral replication><HIV-1 virus replication><HIV-1 virus transmission><HIV/AIDS transmission><HTLV-III Seroconversion><HTLV-III Seropositivity><Histones><Hortega cell><Human Immunodeficiency Virus Type 1 transmission><Human Immunodeficiency Viruses><Human immunodeficiency virus infected patients><Human immunodeficiency virus positive patients><Individual><Induced pluripotent stem cell derived human neuron><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Inflammatory><Investigators><LAV-HTLV-III><LPTN><Libraries><Lineage Tracing><Lymphadenopathy-Associated Virus><Maps><Mediating><Medication><Methylation><Microglia><Modeling><Molecular><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Non-Polyadenylated RNA><Nucleosomes><Opiates><Opioid><Pathology><Pathway interactions><Patients living with HIV><Patients suffering from HIV><Pharmaceutical Preparations><Phase><Position><Positioning Attribute><Protocol><Protocols documentation><Publishing><RNA><RNA Gene Products><Regulatory Element><Repression><Research Personnel><Researchers><Resolution><Ribonucleic Acid><Risk><SCM-1><SCM-1a><SCM1><SCYC1><Single Parent><Single-Nucleus Sequencing><Site><Substance Use Disorder><System><Techniques><Transcription Factor Proto-Oncogene><Transcription Initiation Site><Transcription Start Site><Transcription factor genes><Validation><Viral><Viral Diseases><Virus><Virus Diseases><Virus Integration><Virus-HIV><Work><XCL1><XCL1 gene><anti-retroviral><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><astrocytic glia><brain control><case-control survey><case-controlled studies><cell culture><cell cultures><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><cingulate cortex><co-morbid><co-morbidity><cohort><comorbidity><cytotoxic><design><designing><drug/agent><epigenome editing><epigenomic editing><functional genomics><genome scale><genome-wide><genomewide><gitter cell><global gene expression><global transcription profile><hiPSC-derived neurons><human disease><human iPSC-derived sensory neuron><human immunodeficiency virus infection><human immunodeficiency virus patient><human immunodeficiency virus replication><human immunodeficiency virus transmission><human immunodeficiency virus-1 replication><human induced pluripotent stem cell derived sensory neuron><human tissue><iPSC-derived human neuron><inducible pluripotent stem cell derived human neuron><inducible pluripotent stem cell derived human sensory neuron><infected with HIV><infected with human immunodeficiency virus><innovate><innovation><innovative><insight><member><mesoglia><microglial cell><microgliocyte><multiomics><multiple omics><necropsy><neural inflammation><neurogenomics><neuroinflammation><neuroinflammatory><neuronal><neurons differentiated from human induced pluripotent stem cells><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><opiate consumption><opiate drug use><opiate exposure><opiate intake><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid exposure><opioid intake><opioid use><opioid use disorder><panomics><pathway><patient infected with HIV><patient with HIV><perivascular glial cell><permissiveness><postmortem><promoter><promotor><repressing CRISPR-dCas9 system><resolutions><response><sNuc-Seq><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell transcriptomic profiling><single molecule><single nucleus RNA-sequencing><single nucleus seq><single-cell RNA sequencing><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><spread of human immunodeficiency virus><substance use and disorder><therapeutic agent development><therapeutic development><tool><transcription factor><transcriptome><transcriptomics><validations><viral genome integration><viral infection><viral integration><virus genome integration><virus infection><virus-induced disease>

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Paul J. Kenny

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$2,350,996

FY 2026

Project Title

Mining SCORCH transcriptomics data to resolve functionally relevant striatal cell types

Grant Number:

1R01DA065101-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY This application is submitted in response to RFA-DA-26-001: SCORCH Data Mining and Functional Validation. Human immunodeficiency virus (HIV) infects non-neuronal cells in the brain, particularly microglia, which serve as reservoirs of latent infection. HIV has deleterious effects on ...

Research Terms

<2-dimensional><3-D><3-Dimensional><3D><AIDS Virus><Abstinence><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Affective><Architecture><Archives><Atlases><Axon><Behavior><Behavioral><Behavioral Assay><Brain><Brain Nervous System><Brain region><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Classification><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cognition><Cognitive><Common Rat Strains><Corpus Striatum><Corpus striatum structure><D2 receptor><DRD2 Receptor><Data><Data Set><Dihydrohydroxycodeinone><Dopamine D2 Receptor><Drugs><Electrophysiology><Electrophysiology (science)><Emotions><Encephalon><Engineering / Architecture><Exhibits><Gene Transcription><General Population><General Public><Genes><Genetic><Genetic Transcription><Genomics><Glia><Glial Cells><Goals><HIV><HIV Infections><HIV individuals><HIV infected individuals><HIV infected persons><HIV latency><HIV people><HIV positive individuals><HIV positive people><HIV viral infection><HIV virus infection><HIV-1 infection><History><Hortega cell><Human><Human Immunodeficiency Viruses><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Intravenous><Investigation><Kolliker's reticulum><LAV-HTLV-III><Lymphadenopathy-Associated Virus><MAPseq><Macrophage><Maps><Mediating><Medication><Mice><Mice Mammals><Microglia><Mining><Modern Man><Molecular><Motivation><Multiplexed Analysis of Projections by Sequencing><Murine><Mus><Mφ><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Non-neuronal cell><Nonneuronal cell><Nucleus Accumbens><Opiate replacement therapy><Opiate substitution therapy><Opiate substitution treatment><Opiates><Opioid><Opioid maintenance therapy><Opioid maintenance treatment><Opioid replacement therapy><Opioid replacement treatment><Opioid substitution therapy><Opioid substitution treatment><Output><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><PLWH><PWH><Pharmaceutical Preparations><Phenotype><Population><Property><Public Health><RNA Expression><Rat><Rats Mammals><Rattus><Recording of previous events><Research><Resolution><Rewards><Risk><Risk Factors><Role><Roxicodone><Self Administered><Self Administration><Severities><Single-Nucleus Sequencing><Spatial Distribution><Specificity><Striate Body><Striatum><Subcellular Process><Synapses><Synaptic><System><Systematics><T4 Cells><T4 Lymphocytes><Testing><Transcription><Validation><Virus-HIV><abused drug><abused drugs><antiretroviral therapy><antiretroviral treatment><asymptomatic HIV infection><cell type><chronic HIV infection><co-morbid><co-morbidity><comorbidity><data mining><datamining><differential expression><differentially expressed><drug abused><drug of abuse><drug/agent><drugs abused><drugs of abuse><electrophysiological><experience><functional adaptation><gitter cell><histories><human immunodeficiency virus infection><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><innovate><innovation><innovative><intravenous opiate><intravenous opioid><latent HIV infection><latent infection><mesoglia><microglial cell><microgliocyte><multiomics><multiple omics><nerve cement><neural circuit><neural circuitry><neural mechanism><neurocircuitry><neuromechanism><neuronal><non-human primate><non-medical opioid use><nonhuman primate><nonmedical opioid use><novel><opiate consumption><opiate deaths><opiate drug use><opiate exposure><opiate injection><opiate intake><opiate misuse><opiate mortality><opiate use><opiate use disorder><opioid consumption><opioid deaths><opioid drug use><opioid exposure><opioid injection><opioid injector><opioid intake><opioid misuse><opioid mortality><opioid overdose death><opioid related death><opioid use><opioid use disorder><panomics><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><perivascular glial cell><population based><programs><resolutions><response><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><striatal><synapse><synaptic circuit><synaptic circuitry><three dimensional><transcriptional differences><transcriptomics><two-dimensional><validations>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Mark Bender Gerstein

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$2,263,424

FY 2026

Project Title

Characterizing genetic effects on molecular phenotypes at the single-cell resolution across brain regions in the context of substance use disorder and HIV

Grant Number:

1R01DA065184-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary Millions of individuals are affected with substance use disorders (SUD), posing a significant burden on these individuals, their families, and communities. There is a substantial comorbidity between SUD and HIV infection. HIV is also a risk factor for SUD because of the increased use...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

KE XU

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$2,263,424

FY 2026

Project Title

Characterizing genetic effects on molecular phenotypes at the single-cell resolution across brain regions in the context of substance use disorder and HIV

Grant Number:

1R01DA065184-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary Millions of individuals are affected with substance use disorders (SUD), posing a significant burden on these individuals, their families, and communities. There is a substantial comorbidity between SUD and HIV infection. HIV is also a risk factor for SUD because of the increased use...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

HONGYU ZHAO

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$2,263,424

FY 2026

Project Title

Characterizing genetic effects on molecular phenotypes at the single-cell resolution across brain regions in the context of substance use disorder and HIV

Grant Number:

1R01DA065184-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary Millions of individuals are affected with substance use disorders (SUD), posing a significant burden on these individuals, their families, and communities. There is a substantial comorbidity between SUD and HIV infection. HIV is also a risk factor for SUD because of the increased use...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Christine Cheng

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,387,755

FY 2026

Project Title

Mitochondrial oxidative phosphorylation in substance use disorder and HIV

Grant Number:

1R01DA065090-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary This proposal aims to address the intertwined epidemics of HIV-associated neurocognitive disorders (HAND) and opioid use disorder (OUD) in the context of fentanyl addiction by investigating dysregulated oxidative phosphorylation and testing NAD+ treatment as a novel therapeutic strat...

Research Terms

<3-D><3-Dimensional><3D><AAV vector><AAV-based vector><AIDS Virus><Abstinence><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Actiq><Acute><Address><Adventitial Cell><Animals><Assay><Astrocytes><Astrocytus><Astroglia><Bioassay><Biological><Biological Assay><Blood - brain barrier anatomy><Blood Preservation><Blood brain barrier dysfunction><Blood-Brain Barrier><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Candidate Disease Gene><Candidate Gene><Cas nuclease technology><Cell Body><Cell Nucleus><Cells><Cellular Immune Function><Cessation of life><Chronic><Clinical Management><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Coenzymes><Cognitive deficits><Common Rat Strains><Communities><Cues><DIA4><DT Diaphorase><DTD gene><DTD protein><Data><Death><Dendritic Spines><Dependence><Diaphorase-4><Dihydronicotinamide Adenine Dinucleotide><Diphosphopyridine Nucleotide><Duragesic><Economic Burden><Effectiveness><Electrons><Endothelial Cells><Energy Expenditure><Energy Metabolism><Enzyme Cofactors><Epidemic><Extravasation><Family><Fentanest><Fentanyl><Fentyl><Genes><Genus Hippocampus><Glia><Glial Cells><HIV><HIV 1 associated neurocognitive disorder><HIV associated neurocognitive deficit><HIV associated neurocognitive impairment><HIV individuals><HIV induced neurocognitive deficit><HIV induced neurocognitive impairment><HIV infected individuals><HIV infected persons><HIV intervention><HIV latency><HIV neurocognitive impairment><HIV people><HIV positive individuals><HIV positive people><HIV therapeutic><HIV therapy><HIV treatment><HIV-1 associated neurocognitive deficit><HIV-1 associated neurocognitive disorder><HIV-1 associated neurocognitive impairment><HIV-1 intervention><HIV-1 therapeutic><HIV-1 therapy><HIV-1 treatment><HIV-associated neurocognitive disorder><Health><Health Care Systems><Hemato-Encephalic Barrier><History><Hortega cell><Human><Human Immunodeficiency Virus therapy><Human Immunodeficiency Virus treatment><Human Immunodeficiency Viruses><Immune Cell Activation><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><Individual><Induced pluripotent stem cell derived neurons><Inflammatory><Infumorph><Intermediary Metabolism><Intervention><Intoxication><Investigation><Kadian><Knock-out><Knockout><Kolliker's reticulum><LAV-HTLV-III><Leakage><Life><Lymphadenopathy-Associated Virus><MS Contin><MSir><Mediating><Menadione Reductase><Metabolic Processes><Metabolism><Microglia><Mitochondria><Modeling><Modern Man><Molecular><Morphia><Morphine><Morphology><NAD(P)H Dehydrogenase (Quinone)><NAD(P)H:Menadione Oxidoreductase 1, Dioxin-Inducible 1><NMOR1><NQO1><NQO1 gene><Nadide><Negative Beta Particle><Negatrons><Nerve Cells><Nerve Unit><Neural Cell><Neurocognitive Impairment in HIV><Neurocognitive Impairment in HIV-1><Neurocyte><Neuroglia><Neuroglial Cells><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neuronal Injury><Neurons><Nicotinamide adenine dinucleotide><Nicotinamide-Adenine Dinucleotide><Non-neuronal cell><Nonneuronal cell><Nucleus><Nucleus Accumbens><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Oramorph><Oramorph SR><Organoids><Outcome><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxidative Stress><PLWH><PWH><Pathway interactions><Pericapillary Cell><Pericytes><Perivascular Cell><Phentanyl><Phylloquinone Reductase><Play><Population><Production><Rat><Rats Mammals><Rattus><Recording of previous events><Research><Respiration><Risk><Rodent Model><Role><Rouget Cells><Roxanol><Seahorse><Self Administered><Self Administration><Severities><Single-Nucleus Sequencing><Socioeconomic Factors><Spillage><Statex SR><Substance Use Disorder><Testing><Therapeutic><Time><Upregulation><Viral Burden><Viral Load><Viral Load result><Viral reservoir><Virus reservoir><Virus-HIV><Vulnerable Populations><Withdrawal><Withdrawal Symptom><addiction><addictive disorder><adeno-associated viral vector><adeno-associated virus vector><antiretroviral therapy><antiretroviral treatment><assembloids><astrocytic glia><astrogliosis><asymptomatic HIV infection><behavior test><behavioral test><biologic><bloodbrain barrier><burden of chronic disease><burden of chronic illness><cell type><chronic HIV infection><co-morbid><co-morbidity><coenzyme analog><cognitive defects><comorbidity><dendrite spine><determine efficacy><drug seeking behavior><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><emotional symptom><evaluate efficacy><examine efficacy><fentanyl exposure><fentanyl overdose><fentanyl self-administration><fentanyl use><functional outcomes><gitter cell><glial activation><glial cell activation><histories><human subject><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><immune activation><immune function><improved><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><insight><knock-down><knockdown><latent HIV infection><mesoglia><microglial cell><microgliocyte><mitochondrial><mitochondrial dysfunction><nerve cement><neural inflammation><neurobiological mechanism><neuroinflammation><neuroinflammatory><neuron injury><neuron toxicity><neuronal><neuronal toxicity><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><neurotoxicity><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><opiate use disorder><opiate withdrawal><opioid addiction><opioid dependence><opioid dependent><opioid detox><opioid detoxification><opioid use disorder><opioid withdrawal><overexpress><overexpression><oxycodone self-administration><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><perivascular glial cell><poor health outcome><prevent><preventing><protective effect><reduced health outcome><respiratory mechanism><sNuc-Seq><scRNA sequencing><scRNA-seq><self-administer oxycodone><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single nucleus RNA-sequencing><single nucleus seq><single-cell RNA sequencing><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social><social role><socio-economic factors><substance use and disorder><therapeutic target><three dimensional><transcriptomics><treat HIV><treat Human Immunodeficiency Virus><treatment strategy><vulnerable group><vulnerable individual><vulnerable people><worse health outcome>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Giordano De Guglielmo

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,387,755

FY 2026

Project Title

Mitochondrial oxidative phosphorylation in substance use disorder and HIV

Grant Number:

1R01DA065090-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary This proposal aims to address the intertwined epidemics of HIV-associated neurocognitive disorders (HAND) and opioid use disorder (OUD) in the context of fentanyl addiction by investigating dysregulated oxidative phosphorylation and testing NAD+ treatment as a novel therapeutic strat...

Research Terms

<3-D><3-Dimensional><3D><AAV vector><AAV-based vector><AIDS Virus><Abstinence><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Actiq><Acute><Address><Adventitial Cell><Animals><Assay><Astrocytes><Astrocytus><Astroglia><Bioassay><Biological><Biological Assay><Blood - brain barrier anatomy><Blood Preservation><Blood brain barrier dysfunction><Blood-Brain Barrier><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Candidate Disease Gene><Candidate Gene><Cas nuclease technology><Cell Body><Cell Nucleus><Cells><Cellular Immune Function><Cessation of life><Chronic><Clinical Management><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Coenzymes><Cognitive deficits><Common Rat Strains><Communities><Cues><DIA4><DT Diaphorase><DTD gene><DTD protein><Data><Death><Dendritic Spines><Dependence><Diaphorase-4><Dihydronicotinamide Adenine Dinucleotide><Diphosphopyridine Nucleotide><Duragesic><Economic Burden><Effectiveness><Electrons><Endothelial Cells><Energy Expenditure><Energy Metabolism><Enzyme Cofactors><Epidemic><Extravasation><Family><Fentanest><Fentanyl><Fentyl><Genes><Genus Hippocampus><Glia><Glial Cells><HIV><HIV 1 associated neurocognitive disorder><HIV associated neurocognitive deficit><HIV associated neurocognitive impairment><HIV individuals><HIV induced neurocognitive deficit><HIV induced neurocognitive impairment><HIV infected individuals><HIV infected persons><HIV intervention><HIV latency><HIV neurocognitive impairment><HIV people><HIV positive individuals><HIV positive people><HIV therapeutic><HIV therapy><HIV treatment><HIV-1 associated neurocognitive deficit><HIV-1 associated neurocognitive disorder><HIV-1 associated neurocognitive impairment><HIV-1 intervention><HIV-1 therapeutic><HIV-1 therapy><HIV-1 treatment><HIV-associated neurocognitive disorder><Health><Health Care Systems><Hemato-Encephalic Barrier><History><Hortega cell><Human><Human Immunodeficiency Virus therapy><Human Immunodeficiency Virus treatment><Human Immunodeficiency Viruses><Immune Cell Activation><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><Individual><Induced pluripotent stem cell derived neurons><Inflammatory><Infumorph><Intermediary Metabolism><Intervention><Intoxication><Investigation><Kadian><Knock-out><Knockout><Kolliker's reticulum><LAV-HTLV-III><Leakage><Life><Lymphadenopathy-Associated Virus><MS Contin><MSir><Mediating><Menadione Reductase><Metabolic Processes><Metabolism><Microglia><Mitochondria><Modeling><Modern Man><Molecular><Morphia><Morphine><Morphology><NAD(P)H Dehydrogenase (Quinone)><NAD(P)H:Menadione Oxidoreductase 1, Dioxin-Inducible 1><NMOR1><NQO1><NQO1 gene><Nadide><Negative Beta Particle><Negatrons><Nerve Cells><Nerve Unit><Neural Cell><Neurocognitive Impairment in HIV><Neurocognitive Impairment in HIV-1><Neurocyte><Neuroglia><Neuroglial Cells><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neuronal Injury><Neurons><Nicotinamide adenine dinucleotide><Nicotinamide-Adenine Dinucleotide><Non-neuronal cell><Nonneuronal cell><Nucleus><Nucleus Accumbens><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Oramorph><Oramorph SR><Organoids><Outcome><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxidative Stress><PLWH><PWH><Pathway interactions><Pericapillary Cell><Pericytes><Perivascular Cell><Phentanyl><Phylloquinone Reductase><Play><Population><Production><Rat><Rats Mammals><Rattus><Recording of previous events><Research><Respiration><Risk><Rodent Model><Role><Rouget Cells><Roxanol><Seahorse><Self Administered><Self Administration><Severities><Single-Nucleus Sequencing><Socioeconomic Factors><Spillage><Statex SR><Substance Use Disorder><Testing><Therapeutic><Time><Upregulation><Viral Burden><Viral Load><Viral Load result><Viral reservoir><Virus reservoir><Virus-HIV><Vulnerable Populations><Withdrawal><Withdrawal Symptom><addiction><addictive disorder><adeno-associated viral vector><adeno-associated virus vector><antiretroviral therapy><antiretroviral treatment><assembloids><astrocytic glia><astrogliosis><asymptomatic HIV infection><behavior test><behavioral test><biologic><bloodbrain barrier><burden of chronic disease><burden of chronic illness><cell type><chronic HIV infection><co-morbid><co-morbidity><coenzyme analog><cognitive defects><comorbidity><dendrite spine><determine efficacy><drug seeking behavior><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><emotional symptom><evaluate efficacy><examine efficacy><fentanyl exposure><fentanyl overdose><fentanyl self-administration><fentanyl use><functional outcomes><gitter cell><glial activation><glial cell activation><histories><human subject><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><immune activation><immune function><improved><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><insight><knock-down><knockdown><latent HIV infection><mesoglia><microglial cell><microgliocyte><mitochondrial><mitochondrial dysfunction><nerve cement><neural inflammation><neurobiological mechanism><neuroinflammation><neuroinflammatory><neuron injury><neuron toxicity><neuronal><neuronal toxicity><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><neurotoxicity><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><opiate use disorder><opiate withdrawal><opioid addiction><opioid dependence><opioid dependent><opioid detox><opioid detoxification><opioid use disorder><opioid withdrawal><overexpress><overexpression><oxycodone self-administration><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><perivascular glial cell><poor health outcome><prevent><preventing><protective effect><reduced health outcome><respiratory mechanism><sNuc-Seq><scRNA sequencing><scRNA-seq><self-administer oxycodone><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single nucleus RNA-sequencing><single nucleus seq><single-cell RNA sequencing><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social><social role><socio-economic factors><substance use and disorder><therapeutic target><three dimensional><transcriptomics><treat HIV><treat Human Immunodeficiency Virus><treatment strategy><vulnerable group><vulnerable individual><vulnerable people><worse health outcome>

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Stefano Berto

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$968,242

FY 2026

Project Title

Multiplexed dissection of neuronal ensembles in circuits that underlie the facilitation and disinhibition of opioid and alcohol seeking

Grant Number:

5R01DA062041-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Alcohol and opioid use disorders are characterized by both the facilitation and disinhibition drug seeking and use. Despite this knowledge, the influence of alcohol and opioid use on brain circuits responsible for facilitating and inhibiting natural reward-seeking behaviors remains unclear. ...

Research Terms

<2-photon><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Assay><Behavior><Behavioral><Behavioral Assay><Behavioral inhibition><Bioassay><Biological Assay><Brain><Brain Nervous System><Calcium><Cell Body><Cells><Characteristics><Chronic><Classification><Communities><Complex><Data><Data Set><Diacetylmorphine><Diamorphine><Disinhibition><Dissection><Drug usage><Drugs><Encephalon><EtOH drinking><EtOH use><Extinction><Future><Gene Expression><Gene Transcription><Genetic><Genetic Transcription><Head><Heroin><Holography><Image><In vivo two-photon calcium imaging><Knowledge><Laboratories><Literature><Location><Medication><Methodology><Mice><Mice Mammals><Modeling><Motivation><Murine><Mus><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nucleus Accumbens><Opiates><Opioid><Pharmaceutical Preparations><Population><Prefrontal Cortex><Publications><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Relapse><Research><Rewards><Role><Saccharose><Scientific Publication><Self Administered><Self Administration><Single-Nucleus Sequencing><Substance Use Disorder><Sucrose><Systematics><Testing><Thalamic structure><Thalamus><Transcription><United States><Work><addiction><addictive disorder><alcohol exposed><alcohol exposure><alcohol ingestion><alcohol intake><alcohol misuse><alcohol product use><alcohol seeking><alcohol seeking behavior><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><behavioral disinhibition><drug reward><drug use><drug/agent><ethanol consumption><ethanol drinking><ethanol exposed><ethanol exposure><ethanol ingestion><ethanol intake><ethanol misuse><ethanol product use><ethanol seeking><ethanol use><ethanol use disorder><ethanol-seeking behavior><exposed to alcohol><exposed to ethanol><exposure to alcohol><exposure to ethanol><heroin intake><heroin use><imaging><in vivo><in vivo calcium imaging><innovate><innovation><innovative><maladaptive behavior><motivated behavior><multi-modality><multimodality><neuronal><non-medical opioid use><nonmedical opioid use><opiate consumption><opiate drug use><opiate intake><opiate misuse><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid intake><opioid misuse><opioid use><opioid use disorder><optogenetics><prevent><preventable death><preventable mortality><preventing><recruit><restraint><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><statistics><substance use and disorder><substance use treatment><thalamic><tool><transcriptome sequencing><transcriptomic sequencing><transcriptomics><two-photon><unhealthy alcohol use>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Christopher W Cowan

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$968,242

FY 2026

Project Title

Multiplexed dissection of neuronal ensembles in circuits that underlie the facilitation and disinhibition of opioid and alcohol seeking

Grant Number:

5R01DA062041-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Alcohol and opioid use disorders are characterized by both the facilitation and disinhibition drug seeking and use. Despite this knowledge, the influence of alcohol and opioid use on brain circuits responsible for facilitating and inhibiting natural reward-seeking behaviors remains unclear. ...

Research Terms

<2-photon><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Assay><Behavior><Behavioral><Behavioral Assay><Behavioral inhibition><Bioassay><Biological Assay><Brain><Brain Nervous System><Calcium><Cell Body><Cells><Characteristics><Chronic><Classification><Communities><Complex><Data><Data Set><Diacetylmorphine><Diamorphine><Disinhibition><Dissection><Drug usage><Drugs><Encephalon><EtOH drinking><EtOH use><Extinction><Future><Gene Expression><Gene Transcription><Genetic><Genetic Transcription><Head><Heroin><Holography><Image><In vivo two-photon calcium imaging><Knowledge><Laboratories><Literature><Location><Medication><Methodology><Mice><Mice Mammals><Modeling><Motivation><Murine><Mus><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nucleus Accumbens><Opiates><Opioid><Pharmaceutical Preparations><Population><Prefrontal Cortex><Publications><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Relapse><Research><Rewards><Role><Saccharose><Scientific Publication><Self Administered><Self Administration><Single-Nucleus Sequencing><Substance Use Disorder><Sucrose><Systematics><Testing><Thalamic structure><Thalamus><Transcription><United States><Work><addiction><addictive disorder><alcohol exposed><alcohol exposure><alcohol ingestion><alcohol intake><alcohol misuse><alcohol product use><alcohol seeking><alcohol seeking behavior><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><behavioral disinhibition><drug reward><drug use><drug/agent><ethanol consumption><ethanol drinking><ethanol exposed><ethanol exposure><ethanol ingestion><ethanol intake><ethanol misuse><ethanol product use><ethanol seeking><ethanol use><ethanol use disorder><ethanol-seeking behavior><exposed to alcohol><exposed to ethanol><exposure to alcohol><exposure to ethanol><heroin intake><heroin use><imaging><in vivo><in vivo calcium imaging><innovate><innovation><innovative><maladaptive behavior><motivated behavior><multi-modality><multimodality><neuronal><non-medical opioid use><nonmedical opioid use><opiate consumption><opiate drug use><opiate intake><opiate misuse><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid intake><opioid misuse><opioid use><opioid use disorder><optogenetics><prevent><preventable death><preventable mortality><preventing><recruit><restraint><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><statistics><substance use and disorder><substance use treatment><thalamic><tool><transcriptome sequencing><transcriptomic sequencing><transcriptomics><two-photon><unhealthy alcohol use>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

James M Otis

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$968,242

FY 2026

Project Title

Multiplexed dissection of neuronal ensembles in circuits that underlie the facilitation and disinhibition of opioid and alcohol seeking

Grant Number:

5R01DA062041-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Alcohol and opioid use disorders are characterized by both the facilitation and disinhibition drug seeking and use. Despite this knowledge, the influence of alcohol and opioid use on brain circuits responsible for facilitating and inhibiting natural reward-seeking behaviors remains unclear. ...

Research Terms

<2-photon><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Assay><Behavior><Behavioral><Behavioral Assay><Behavioral inhibition><Bioassay><Biological Assay><Brain><Brain Nervous System><Calcium><Cell Body><Cells><Characteristics><Chronic><Classification><Communities><Complex><Data><Data Set><Diacetylmorphine><Diamorphine><Disinhibition><Dissection><Drug usage><Drugs><Encephalon><EtOH drinking><EtOH use><Extinction><Future><Gene Expression><Gene Transcription><Genetic><Genetic Transcription><Head><Heroin><Holography><Image><In vivo two-photon calcium imaging><Knowledge><Laboratories><Literature><Location><Medication><Methodology><Mice><Mice Mammals><Modeling><Motivation><Murine><Mus><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nucleus Accumbens><Opiates><Opioid><Pharmaceutical Preparations><Population><Prefrontal Cortex><Publications><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Relapse><Research><Rewards><Role><Saccharose><Scientific Publication><Self Administered><Self Administration><Single-Nucleus Sequencing><Substance Use Disorder><Sucrose><Systematics><Testing><Thalamic structure><Thalamus><Transcription><United States><Work><addiction><addictive disorder><alcohol exposed><alcohol exposure><alcohol ingestion><alcohol intake><alcohol misuse><alcohol product use><alcohol seeking><alcohol seeking behavior><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><behavioral disinhibition><drug reward><drug use><drug/agent><ethanol consumption><ethanol drinking><ethanol exposed><ethanol exposure><ethanol ingestion><ethanol intake><ethanol misuse><ethanol product use><ethanol seeking><ethanol use><ethanol use disorder><ethanol-seeking behavior><exposed to alcohol><exposed to ethanol><exposure to alcohol><exposure to ethanol><heroin intake><heroin use><imaging><in vivo><in vivo calcium imaging><innovate><innovation><innovative><maladaptive behavior><motivated behavior><multi-modality><multimodality><neuronal><non-medical opioid use><nonmedical opioid use><opiate consumption><opiate drug use><opiate intake><opiate misuse><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid intake><opioid misuse><opioid use><opioid use disorder><optogenetics><prevent><preventable death><preventable mortality><preventing><recruit><restraint><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><statistics><substance use and disorder><substance use treatment><thalamic><tool><transcriptome sequencing><transcriptomic sequencing><transcriptomics><two-photon><unhealthy alcohol use>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jennifer Anne Rinker

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$968,242

FY 2026

Project Title

Multiplexed dissection of neuronal ensembles in circuits that underlie the facilitation and disinhibition of opioid and alcohol seeking

Grant Number:

5R01DA062041-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Alcohol and opioid use disorders are characterized by both the facilitation and disinhibition drug seeking and use. Despite this knowledge, the influence of alcohol and opioid use on brain circuits responsible for facilitating and inhibiting natural reward-seeking behaviors remains unclear. ...

Research Terms

<2-photon><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Assay><Behavior><Behavioral><Behavioral Assay><Behavioral inhibition><Bioassay><Biological Assay><Brain><Brain Nervous System><Calcium><Cell Body><Cells><Characteristics><Chronic><Classification><Communities><Complex><Data><Data Set><Diacetylmorphine><Diamorphine><Disinhibition><Dissection><Drug usage><Drugs><Encephalon><EtOH drinking><EtOH use><Extinction><Future><Gene Expression><Gene Transcription><Genetic><Genetic Transcription><Head><Heroin><Holography><Image><In vivo two-photon calcium imaging><Knowledge><Laboratories><Literature><Location><Medication><Methodology><Mice><Mice Mammals><Modeling><Motivation><Murine><Mus><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nucleus Accumbens><Opiates><Opioid><Pharmaceutical Preparations><Population><Prefrontal Cortex><Publications><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Relapse><Research><Rewards><Role><Saccharose><Scientific Publication><Self Administered><Self Administration><Single-Nucleus Sequencing><Substance Use Disorder><Sucrose><Systematics><Testing><Thalamic structure><Thalamus><Transcription><United States><Work><addiction><addictive disorder><alcohol exposed><alcohol exposure><alcohol ingestion><alcohol intake><alcohol misuse><alcohol product use><alcohol seeking><alcohol seeking behavior><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><behavioral disinhibition><drug reward><drug use><drug/agent><ethanol consumption><ethanol drinking><ethanol exposed><ethanol exposure><ethanol ingestion><ethanol intake><ethanol misuse><ethanol product use><ethanol seeking><ethanol use><ethanol use disorder><ethanol-seeking behavior><exposed to alcohol><exposed to ethanol><exposure to alcohol><exposure to ethanol><heroin intake><heroin use><imaging><in vivo><in vivo calcium imaging><innovate><innovation><innovative><maladaptive behavior><motivated behavior><multi-modality><multimodality><neuronal><non-medical opioid use><nonmedical opioid use><opiate consumption><opiate drug use><opiate intake><opiate misuse><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid intake><opioid misuse><opioid use><opioid use disorder><optogenetics><prevent><preventable death><preventable mortality><preventing><recruit><restraint><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><statistics><substance use and disorder><substance use treatment><thalamic><tool><transcriptome sequencing><transcriptomic sequencing><transcriptomics><two-photon><unhealthy alcohol use>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

GUSTAVO Adolfo ANGARITA

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$810,445

FY 2026

Project Title

Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder

Grant Number:

5R01DA060231-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder The opioid epidemic is one of the worse U.S. public health crises of the past three decades [1]. In response to this epidemic, the National Institute of Health launched a multi-pronged initiative a goal to develop ...

Research Terms

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Ansel Hillmer

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$810,445

FY 2026

Project Title

Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder

Grant Number:

5R01DA060231-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder The opioid epidemic is one of the worse U.S. public health crises of the past three decades [1]. In response to this epidemic, the National Institute of Health launched a multi-pronged initiative a goal to develop ...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

DAVID A MATUSKEY

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$810,445

FY 2026

Project Title

Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder

Grant Number:

5R01DA060231-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder The opioid epidemic is one of the worse U.S. public health crises of the past three decades [1]. In response to this epidemic, the National Institute of Health launched a multi-pronged initiative a goal to develop ...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sarah Yip

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$810,445

FY 2026

Project Title

Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder

Grant Number:

5R01DA060231-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract Imaging Brain Kappa Opioid Receptors in Early Abstinence Opioid Use Disorder The opioid epidemic is one of the worse U.S. public health crises of the past three decades [1]. In response to this epidemic, the National Institute of Health launched a multi-pronged initiative a goal to develop ...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jacob T Borodovsky

DARTMOUTH COLLEGE, HANOVER, NH

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$780,228

FY 2026

Project Title

Cannabis Use for Chronic Pain: Advancing Knowledge and Cannabis Use Disorder Assessment with a Mixed Methods Approach

Grant Number:

2R01DA050032-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2020

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

U.S. adult rates of cannabis use and DSM-5 Cannabis Use Disorder (CUD) have now reached historic peaks, medical cannabis use for pain is legal in 40 states, and the FDA has recommended re-classifying cannabis from Schedule 1 (no medical use, high abuse potential) to Schedule 3 (use for pain, moderat...

Research Terms

<21+ years old><Address><Adult><Adult Human><Anxiety><Area><Authorization><Authorization documentation><Behavior><Cannabis><Causality><Classification><Clinical><Clinical Trials><Complex><Consumption><DSM-5><DSM-V><DSM5><Dependence><Diagnosis><Diagnostic><Diagnostic and Statistical Manual of Mental Disorders, 5th edition><Diagnostic and Statistical Manual of Mental Disorders-V><Disease><Disorder><Dose><Eligibility><Eligibility Determination><Ensure><Environmental Factor><Environmental Risk Factor><Etiology><Face><Future><Genetic predisposing factor><Goals><Guidelines><Health><Individual><Interviewer><Knowledge><Left><Legal><Legal Status><Measurement><Measures><Medical><Medical Marijuana><Medicinal Marijuana><Methods><Modeling><Opiates><Opioid><Pain><Painful><Participant><Permission><Physiologic><Physiological><Prevalence><Protocol Screening><Psychoactive Agents><Psychoactive Compound><Psychoactive Drugs><Psychopharmaceuticals><Psychotropic Drugs><Public Health><Recommendation><Research><Role><Sampling><Schedule><Self Administered><Self Administration><Sleep><Specific qualifier value><Specified><Standardization><Substance Use Disorder><Substance administration><Supervision><Survey Instrument><Surveys><Systematics><THC co-use><THC use><Testing><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Therapeutic><Therapeutic Uses><Training><Update><Validity and Reliability><Withdrawal><abuse liability><abuse potential><accurate diagnosis><adulthood><cannabis use><cannabis use disorder><cannabis user><causation><chronic pain><cognitive interview><diagnostic criteria><disease causation><disease model><disorder model><dose information><environmental risk><faces><facial><genetic risk factor><improved><indexing><inherited factor><instrument><licit opioid><marijuana use><marijuana use and disorder><marijuana use disorder><marijuana user><medical cannabis><medicinal cannabis><novel><opiate consumption><opiate drug use><opiate intake><opiate medication><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid intake><opioid medication><opioid use><opioid use disorder><pain relief><pilot test><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><relieve pain><social role><substance use and disorder><therapeutic cannabis><therapeutic marijuana>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

DEBORAH S HASIN

DARTMOUTH COLLEGE, HANOVER, NH

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$780,228

FY 2026

Project Title

Cannabis Use for Chronic Pain: Advancing Knowledge and Cannabis Use Disorder Assessment with a Mixed Methods Approach

Grant Number:

2R01DA050032-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2020

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

U.S. adult rates of cannabis use and DSM-5 Cannabis Use Disorder (CUD) have now reached historic peaks, medical cannabis use for pain is legal in 40 states, and the FDA has recommended re-classifying cannabis from Schedule 1 (no medical use, high abuse potential) to Schedule 3 (use for pain, moderat...

Research Terms

<21+ years old><Address><Adult><Adult Human><Anxiety><Area><Authorization><Authorization documentation><Behavior><Cannabis><Causality><Classification><Clinical><Clinical Trials><Complex><Consumption><DSM-5><DSM-V><DSM5><Dependence><Diagnosis><Diagnostic><Diagnostic and Statistical Manual of Mental Disorders, 5th edition><Diagnostic and Statistical Manual of Mental Disorders-V><Disease><Disorder><Dose><Eligibility><Eligibility Determination><Ensure><Environmental Factor><Environmental Risk Factor><Etiology><Face><Future><Genetic predisposing factor><Goals><Guidelines><Health><Individual><Interviewer><Knowledge><Left><Legal><Legal Status><Measurement><Measures><Medical><Medical Marijuana><Medicinal Marijuana><Methods><Modeling><Opiates><Opioid><Pain><Painful><Participant><Permission><Physiologic><Physiological><Prevalence><Protocol Screening><Psychoactive Agents><Psychoactive Compound><Psychoactive Drugs><Psychopharmaceuticals><Psychotropic Drugs><Public Health><Recommendation><Research><Role><Sampling><Schedule><Self Administered><Self Administration><Sleep><Specific qualifier value><Specified><Standardization><Substance Use Disorder><Substance administration><Supervision><Survey Instrument><Surveys><Systematics><THC co-use><THC use><Testing><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Therapeutic><Therapeutic Uses><Training><Update><Validity and Reliability><Withdrawal><abuse liability><abuse potential><accurate diagnosis><adulthood><cannabis use><cannabis use disorder><cannabis user><causation><chronic pain><cognitive interview><diagnostic criteria><disease causation><disease model><disorder model><dose information><environmental risk><faces><facial><genetic risk factor><improved><indexing><inherited factor><instrument><licit opioid><marijuana use><marijuana use and disorder><marijuana use disorder><marijuana user><medical cannabis><medicinal cannabis><novel><opiate consumption><opiate drug use><opiate intake><opiate medication><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid intake><opioid medication><opioid use><opioid use disorder><pain relief><pilot test><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><relieve pain><social role><substance use and disorder><therapeutic cannabis><therapeutic marijuana>

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Nafisseh S Warner

MAYO CLINIC ROCHESTER, ROCHESTER, MN

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$770,630

FY 2026

Project Title

Prescription opioids, brain structure, and cognition in older adults with chronic pain

Grant Number:

5R01AG090601-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Chronic pain is experienced by more than 30% of older adults (>65 years of age), many of whom receive prescription opioids despite well-described adverse effects including gastrointestinal distress, constipation, physical dependence, and respiratory depression. More recently...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Acceleration><Address><Adverse effects><Age><Age Years><Aged 65 and Over><Alternative Therapies><Alternative intervention><Amentia><Anisotropy><Anterior><Automobile Driving><Axon><Biological><Brain><Brain Nervous System><Caring><Cerebrum><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Constipation><Corpus Callosum><Corpus Callosums><Data><Degenerative Arthritis><Degenerative polyarthritis><Dementia><Diagnosis><Distress><Disturbance in cognition><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Drugs><Elderly><Emotional><Encephalon><Enrollment><Exposure to><Extremities><Family><Fear><Friends><Fright><Health system><Image><Impaired cognition><Impairment><Individual><Internal Capsule><Intervention><Limb structure><Limbs><Link><Longitudinal observational study><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Mediating><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Memory><Mental Health><Mental Hygiene><Methods><Modality><Myelin><NMR Imaging><NMR Tomography><Non-Trunk><Nuclear Magnetic Resonance Imaging><Observational Study><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Opiates><Opioid><Opioid Analgesics><Osteoarthritis><Osteoarthrosis><Outcome><Pain><Pain Control><Pain Therapy><Pain management><Painful><Participant><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Pharmaceutical Preparations><Physical Dependence><Physical Function><Placebo Control><Placebos><Population><Population Study><Production><Protocol><Protocols documentation><Psychological Health><QOL><Quality of life><Randomized><Research><Respiratory Depression><Risk><Role><Secondary to><Sham Treatment><Sleep><Societies><Structure><Testing><Titrations><Treatment Period><Ventilatory Depression><Work><Zeugmatography><above age 65><adult youth><advanced age><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><ages><biologic><cerebral><chronic pain><clinical decision-making><clinical practice><cognitive change><cognitive dysfunction><cognitive loss><degenerative joint disease><depressed breathing><depression of breathing><double-blind placebo control trial><double-blind placebo controlled trial><double-masked controlled trial><driving><drug/agent><effective therapy><effective treatment><enroll><evidence base><experience><gastrointestinal><geriatric><gray matter><human old age (65+)><hypertrophic arthritis><imaging><innovate><innovation><innovative><licit opioid><long term observational study><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><morphometry><neurocognitive test><observational research study><observational survey><older adult><older adulthood><opiate analgesia><opiate analgesic><opiate exposure><opiate medication><opiate pain medication><opiate pain reliever><opiate therapy><opioid analgesia><opioid anesthetic><opioid exposure><opioid medication><opioid pain medication><opioid pain reliever><opioid painkiller><opioid therapy><over 65 years><pain intervention><pain score><pain treatment><pathway><patient centered><patient oriented><patient oriented outcomes><placebo controlled><population research study><population survey><population-based study><population-level study><pre-clinical study><preclinical study><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><preservation><primary outcome><randomisation><randomization><randomized placebo-controlled clinical trial><randomized, clinical trials><randomly assigned><secondary outcome><senior citizen><sham therapy><shared decision making><social role><stria terminalis><substantia alba><substantia grisea><treatment days><treatment duration><white matter><young adult><young adult age><young adulthood><≥65 years>

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Gabriel Lazaro-Munoz

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$769,268

FY 2026

Project Title

Genomic Tests for Substance Use Disorders in Clinical Care: Examining Challenges and Opportunities

Grant Number:

1R01DA062848-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

In 2023, more than 100,000 people died of an opioid overdose in the United States, and 2.5 million adults in the U.S. have an opioid use disorder (OUD). Paradoxically, people’s access to opioids often happens in the context of medical procedures and are prescribed by clinicians. Opioids are effectiv...

Research Terms

<21+ years old><Address><Adult><Adult Human><Back><Caring><Clinical><Cognitive Discrimination><Consensus><Data><Decision Making><Demographic Factors><Development><Discrimination><Doctor's Assistants><Dorsum><ELSI><Empirical Research><Equilibrium><Ethics><FDA approved><Food and Drug Administration><Funding><Genetic><Genetic Risk><Genomic Testing><Genomics><Goals><History><Iatrogenesis><Interview><Investigators><Laws><Legal><Medical><Medical Records><Medicine><Methods><NIH><National Institutes of Health><Neurosurgeon><Nurse Practitioners><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Orthopedic><Orthopedic Surgical Profession><Orthopedics><Other Genetics><Outcome><Pain><Pain Control><Pain Therapy><Pain management><Painful><Patient Schedules><Patients><Personal Satisfaction><Persons><Physician Assistants><Physicians' Extenders><Procedures><Psychiatrist><Recording of previous events><Reporting><Research><Research Personnel><Researchers><Risk><Risk Assessment><Risk Estimate><Specialist><Spinal surgery><Spine surgery><Stigmatization><Structure><Substance Use Disorder><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Survey Instrument><Surveys><Testing><USFDA><United States><United States Food and Drug Administration><United States National Institutes of Health><Work><addiction><addictive disorder><adulthood><balance><balance function><clinical care><clinical geneticist><developmental><disease risk><disorder risk><ethical><ethical legal and social><ethical, legal, and social implication><expectation><experiment><experimental research><experimental study><experiments><gene testing><gene-based testing><genetic counselor><genetic testing><genetics clinician><genetics physician><genome based testing><genome sciences><genome testing><genomic DNA testing><genomic based testing><genomic clinical testing><genomic profiling testing><genomic science><genomic screening test><genomic tools><histories><iatrogenic><iatrogenically><iatrogenicity><improved><innovate><innovation><innovative><licit opioid><medical geneticist><neuro-surgeon><novel><opiate consumption><opiate deaths><opiate drug use><opiate intake><opiate medication><opiate mortality><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid deaths><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication><opioid medication overdose><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><overdose death><overdose fatalities><pain intervention><pain treatment><polygenetic risk scores><polygenic risk score><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent><preventing><psychiatric genetics><psychogenetics><public health emergency><substance use and disorder><surgery><tool><well-being><wellbeing>

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Amanda Rae Merner

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$769,268

FY 2026

Project Title

Genomic Tests for Substance Use Disorders in Clinical Care: Examining Challenges and Opportunities

Grant Number:

1R01DA062848-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

In 2023, more than 100,000 people died of an opioid overdose in the United States, and 2.5 million adults in the U.S. have an opioid use disorder (OUD). Paradoxically, people’s access to opioids often happens in the context of medical procedures and are prescribed by clinicians. Opioids are effectiv...

Research Terms

<21+ years old><Address><Adult><Adult Human><Back><Caring><Clinical><Cognitive Discrimination><Consensus><Data><Decision Making><Demographic Factors><Development><Discrimination><Doctor's Assistants><Dorsum><ELSI><Empirical Research><Equilibrium><Ethics><FDA approved><Food and Drug Administration><Funding><Genetic><Genetic Risk><Genomic Testing><Genomics><Goals><History><Iatrogenesis><Interview><Investigators><Laws><Legal><Medical><Medical Records><Medicine><Methods><NIH><National Institutes of Health><Neurosurgeon><Nurse Practitioners><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Orthopedic><Orthopedic Surgical Profession><Orthopedics><Other Genetics><Outcome><Pain><Pain Control><Pain Therapy><Pain management><Painful><Patient Schedules><Patients><Personal Satisfaction><Persons><Physician Assistants><Physicians' Extenders><Procedures><Psychiatrist><Recording of previous events><Reporting><Research><Research Personnel><Researchers><Risk><Risk Assessment><Risk Estimate><Specialist><Spinal surgery><Spine surgery><Stigmatization><Structure><Substance Use Disorder><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Survey Instrument><Surveys><Testing><USFDA><United States><United States Food and Drug Administration><United States National Institutes of Health><Work><addiction><addictive disorder><adulthood><balance><balance function><clinical care><clinical geneticist><developmental><disease risk><disorder risk><ethical><ethical legal and social><ethical, legal, and social implication><expectation><experiment><experimental research><experimental study><experiments><gene testing><gene-based testing><genetic counselor><genetic testing><genetics clinician><genetics physician><genome based testing><genome sciences><genome testing><genomic DNA testing><genomic based testing><genomic clinical testing><genomic profiling testing><genomic science><genomic screening test><genomic tools><histories><iatrogenic><iatrogenically><iatrogenicity><improved><innovate><innovation><innovative><licit opioid><medical geneticist><neuro-surgeon><novel><opiate consumption><opiate deaths><opiate drug use><opiate intake><opiate medication><opiate mortality><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid deaths><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication><opioid medication overdose><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><overdose death><overdose fatalities><pain intervention><pain treatment><polygenetic risk scores><polygenic risk score><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent><preventing><psychiatric genetics><psychogenetics><public health emergency><substance use and disorder><surgery><tool><well-being><wellbeing>

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Theresa Williamson

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$769,268

FY 2026

Project Title

Genomic Tests for Substance Use Disorders in Clinical Care: Examining Challenges and Opportunities

Grant Number:

1R01DA062848-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

In 2023, more than 100,000 people died of an opioid overdose in the United States, and 2.5 million adults in the U.S. have an opioid use disorder (OUD). Paradoxically, people’s access to opioids often happens in the context of medical procedures and are prescribed by clinicians. Opioids are effectiv...

Research Terms

<21+ years old><Address><Adult><Adult Human><Back><Caring><Clinical><Cognitive Discrimination><Consensus><Data><Decision Making><Demographic Factors><Development><Discrimination><Doctor's Assistants><Dorsum><ELSI><Empirical Research><Equilibrium><Ethics><FDA approved><Food and Drug Administration><Funding><Genetic><Genetic Risk><Genomic Testing><Genomics><Goals><History><Iatrogenesis><Interview><Investigators><Laws><Legal><Medical><Medical Records><Medicine><Methods><NIH><National Institutes of Health><Neurosurgeon><Nurse Practitioners><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Orthopedic><Orthopedic Surgical Profession><Orthopedics><Other Genetics><Outcome><Pain><Pain Control><Pain Therapy><Pain management><Painful><Patient Schedules><Patients><Personal Satisfaction><Persons><Physician Assistants><Physicians' Extenders><Procedures><Psychiatrist><Recording of previous events><Reporting><Research><Research Personnel><Researchers><Risk><Risk Assessment><Risk Estimate><Specialist><Spinal surgery><Spine surgery><Stigmatization><Structure><Substance Use Disorder><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Survey Instrument><Surveys><Testing><USFDA><United States><United States Food and Drug Administration><United States National Institutes of Health><Work><addiction><addictive disorder><adulthood><balance><balance function><clinical care><clinical geneticist><developmental><disease risk><disorder risk><ethical><ethical legal and social><ethical, legal, and social implication><expectation><experiment><experimental research><experimental study><experiments><gene testing><gene-based testing><genetic counselor><genetic testing><genetics clinician><genetics physician><genome based testing><genome sciences><genome testing><genomic DNA testing><genomic based testing><genomic clinical testing><genomic profiling testing><genomic science><genomic screening test><genomic tools><histories><iatrogenic><iatrogenically><iatrogenicity><improved><innovate><innovation><innovative><licit opioid><medical geneticist><neuro-surgeon><novel><opiate consumption><opiate deaths><opiate drug use><opiate intake><opiate medication><opiate mortality><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid deaths><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication><opioid medication overdose><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><overdose death><overdose fatalities><pain intervention><pain treatment><polygenetic risk scores><polygenic risk score><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent><preventing><psychiatric genetics><psychogenetics><public health emergency><substance use and disorder><surgery><tool><well-being><wellbeing>

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Antoine Chaillon

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$710,087

FY 2026

Project Title

Disentangling the HIV/opioid intertwined mechanisms on mitochondrial mediated inflammasome activation, neurotoxicity and targeting strategies: In vivo and in vitro analyses of fresh human brain

Grant Number:

5R01DA062278-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary. Despite effective antiretrovirals (ARV), Human Immunodeficiency Virus (HIV) spreads within the central nervous system (CNS) and establishes persistent infection precipitating cognitive impairment (CI). Recent findings suggest that HIV protein (namely VPR) expression in the brain activates t...

Research Terms

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Jerel Adam Fields

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$710,087

FY 2026

Project Title

Disentangling the HIV/opioid intertwined mechanisms on mitochondrial mediated inflammasome activation, neurotoxicity and targeting strategies: In vivo and in vitro analyses of fresh human brain

Grant Number:

5R01DA062278-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary. Despite effective antiretrovirals (ARV), Human Immunodeficiency Virus (HIV) spreads within the central nervous system (CNS) and establishes persistent infection precipitating cognitive impairment (CI). Recent findings suggest that HIV protein (namely VPR) expression in the brain activates t...

Research Terms

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Kurt F Hauser

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$697,583

FY 2026

Project Title

pTau-related neuron and cognitive dysfunction in opioid-HIV comorbidity: Longitudinal and functional studies

Grant Number:

5R01DA060762-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

HIV associated neurocognitive disorder (HAND) affects ~50% of people living with HIV (PWH), and concurrent opioid use disorder (OUD) can enhance symptoms. Since CNS pathology in HIV associated neurocognitive disorder (HAND) bears similarities to Alzheimer’s disease (AD) and other ‘tauopathies’ in wh...

Research Terms

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Pamela E Knapp

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$697,583

FY 2026

Project Title

pTau-related neuron and cognitive dysfunction in opioid-HIV comorbidity: Longitudinal and functional studies

Grant Number:

5R01DA060762-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

HIV associated neurocognitive disorder (HAND) affects ~50% of people living with HIV (PWH), and concurrent opioid use disorder (OUD) can enhance symptoms. Since CNS pathology in HIV associated neurocognitive disorder (HAND) bears similarities to Alzheimer’s disease (AD) and other ‘tauopathies’ in wh...

Research Terms

View Full Project Details on NIH Reporter

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CHARLES J NEIGHBORS

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$696,133

FY 2026

Project Title

Organizational factors associated with quality of care for opioid use disorders among transition-age adults in Medicaid

Grant Number:

5R01DA057267-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

2/28/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Transition-age (TA) adulthood—between ages 18 to 25—is a distinct and critical developmental period where unique biological, psychological, and social changes are occurring. Brain development continues into the latter part of this period, with neurological structures associated with ...

Research Terms

<18 year old><18 years of age><21+ years old><Adanon><Adherence><Adult><Adult Human><Adverse Experience><Adverse event><Age><Althose><Application Context><Biological><Bionomics><Brain><Brain Nervous System><Budgets><Buprenorphine><COVID-19><CV-19><Caring><Characteristics><Client><Clinical><Communities><Complex><Coronavirus Infectious Disease 2019><Counseling><Development><Diagnosis><Dolophine><Dose><Drug Therapy><Drugs><Early treatment><Ecology><Encephalon><Event><Family><Government><Homelessness><Hospitals><Impoverished><Incentives><Individual><Informal Social Control><Lead><Longitudinal Studies><Longitudinal Surveys><Medicaid><Medication><Mental Health><Mental Hygiene><Methadone><Methadose><Modeling><Nalorex><Naltrexone><Nemexin><Neurologic><Neurological><Organization Charts><Organizational Change><Outcome><Overdose><Patients><Pb element><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Policies><Population><Poverty><Prevalence><Process><Process Measure><Provider><Psychological Health><Public Health><QOC><Quality of Care><ReVia><Registries><Rewards><Role><Self Regulation><Social Change><Social modification><Social transformation><Structure><Substance Use Disorder><System><Telemedicine><Time><Variant><Variation><Vivitrol><access to medications><adult youth><adulthood><age 18><age 18 years><age group><ages><biologic><clinical care><clinical decision-making><co-morbid><co-morbidity><cohort><community factor><community-level factor><comorbidity><contextual factors><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><critical developmental period><developmental><disparities in race><disparity due to race><disparity in ethnic><drug intervention><drug treatment><drug/agent><early therapy><effective therapy><effective treatment><efficacious therapy><efficacious treatment><eighteen year old><eighteen years of age><ethnic based disparity><ethnic disadvantage><ethnic disparity><ethnic inequality><ethnic inequity><ethnicity disparity><heavy metal Pb><heavy metal lead><homeless><houselessness><improved><indexing><inequality due to race><inequity due to race><long-term study><longitudinal outcome studies><longitudinal research study><medication access><medication for opioid use disorder><multiple data sources><opiate use disorder><opioid use disorder><organizational structure><parent monitoring><parental monitoring><peer><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><programs><psychologic><psychological><public health emergency><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial disparity><racial inequality><racial inequity><racially unequal><response><social><social expectations><social health determinants><social role><social vulnerability><societal expectations><structural determinants><structural factors><substance use and disorder><telehealth><treatment program><unhoused><young adult><young adult age><young adulthood>

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ROBERT HEIMER

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$690,308

FY 2026

Project Title

Applying a multiple methods approach to examine spatial and temporal variability in a state's illicit drug market

Grant Number:

5R01DA062622-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT The US is currently in the middle of the fourth wave of the opioid overdose crisis. This wave has been characterized by multiple factors. The first is the dominance of fentanyl and related compounds in the illicit drug marketplace. The second factor has been the introduction of adulterants...

Research Terms

<2-amino-1-phenyl 1-propanone><2-aminopropiophenone><Accident and Emergency department><Actiq><Address><Agonist><Antipsychotic Agents><Antipsychotic Drugs><Antipsychotics><Autopsy><BIPOC><Black, Indigenous, People of Color><Canada><Cessation of life><Chemicals><Circulation><Cities><Cocaine><Communities><Complement><Complement Proteins><Connecticut><Crystal Meth><Crystal methamphetamine><Data><Data Set><Death><Deoxyephedrine><Desoxyephedrine><Detection><Development><Diacetylmorphine><Diamorphine><Drug Monitoring><Drug Synthesis and Chemistry><Drug usage><Drug user><Drugs><Duragesic><Emergency Department><Emergency room><Event><Fentanest><Fentanyl><Fentyl><Frequencies><Geography><Harm Minimization><Harm Reduction><Health><Heroin><Human><Illicit Drugs><Incidence><Individual><Intervention><Levomedetomidine><Link><Literature><Major Tranquilizers><Major Tranquilizing Agents><Marketing><Measures><Medetomidine><Medical><Medical Examiners><Medication><Methamphetamine><Methods><Methylamphetamine><Midwest><Midwest U.S.><Midwest US><Midwestern United States><Modeling><Modern Man><Morbidity><Municipalities><N-Methylamphetamine><Neighborhoods><Neuroleptic Agents><Neuroleptic Drugs><Neuroleptics><Neurontin><Opiates><Opioid><Overdose><Overdose reduction><PWUD><Pattern><Persons><Pharmaceutical Preparations><Phentanyl><Polypharmacy><Prevalence><Procedures><Psychoactive Agents><Psychoactive Compound><Psychoactive Drugs><Psychopharmaceuticals><Psychotropic Drugs><Public Health><Publishing><Records><Reporting><Respondent><Risk><Safety><Sampling><Series><Site><Smoke><Specialist><Stimulant><Stream><Street Drugs><System><Systems Integration><Testing><Time><Toxicology><Variant><Variation><Work><Xylaxine><Xylazine><addiction><addictive disorder><alpha-aminopropiophenone><analog><bath salts><cathinine><cathinone><complementation><computer based prediction><data integration><data streams><design><designing><develop therapy><developmental><drug detection><drug market><drug synthesis><drug testing><drug use><drug/agent><experience><gabapentin><harm reduction programs><integrated system><interest><intervention development><meth><mortality><necropsy><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><opiate overdose><opiate related overdose><opiate use disorder><opioid drug overdose><opioid induced overdose><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use disorder><overdose death><overdose fatalities><pathogen><people who use drugs><people who use illicit drugs><persons who use drugs><postmortem><predictive modeling><reduce overdose><reduction in overdose><response><sedative><spatial and temporal><spatial temporal><spatiotemporal><synthetic cannabinoid><synthetic cathinones><synthetic opiate><synthetic opioid><system integration><therapy development><treatment development><trend><waste water based testing><waste water sampling><waste water testing><wastewater based testing><wastewater sampling><wastewater testing>

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Carolyn Christa Cannuscio

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$688,228

FY 2026

Project Title

Increasing naloxone availability and use in high-risk settings: public libraries as partners for reducing opioid overdose mortality

Grant Number:

5R01DA060889-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Opioid overdose mortality has increased substantially since the start of the COVID-19 pandemic. Opioid overdose deaths are preventable and can be reversed with the timely receipt of naloxone. To date, naloxone distribution and implementation programs have targeted traditiona...

Research Terms

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Alip Ghosh

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$685,937

FY 2026

Project Title

Impact of opioid use disorder on mitochondrial dysfunction among antiretroviral therapy-receiving aging people with HIV.

Grant Number:

1R01DA065079-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Use of antiretroviral therapy (ART) has considerably increased life expectancy for people with HIV (PWH) resulting in increased risk of age-related non-AIDS-defining health burden, including inflammaging, a low-grade chronic proinflammatory immune response, among the older population of PWH compared...

Research Terms

<(TNF)-α><3-10C><3-Pyridinecarboxamide><AIDS Virus><AMCF-I><Abscission><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Oxygen><Adenosine><Adenosine Triphosphate><Adenylpyrophosphate><Affect><Age><Aging><Autoregulation><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cells><B-Lymphocytes><B-cell><BCDF><BSF-2><BSF2><Biochemical Process><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood monocyte><CCL20><CCL20 gene><CRG-2><CXCL10><CXCL10 gene><CXCL8><Cachectin><Calcium><Cell Aging><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cells><Cellular Aging><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Cellular Senescence><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Chemokine, CC Motif, Ligand 20><Chronic><Cytotoxic cell><Data><Dinucleoside Phosphates><Edodekin Alfa><Excision><Exodus 1><Extirpation><Fatty Acids><GCP1><General Population><General Public><Generations><Genes><HIV><HIV Seronegativities><HIV Seronegativity><HIV and aging><HIV associated aging><HIV individuals><HIV infected individuals><HIV infected persons><HIV latency><HIV negative><HIV people><HIV positive individuals><HIV positive people><HIV related aging><HPGF><HTLV-III Seronegativities><HTLV-III Seronegativity><Health><Hepatocyte-Stimulating Factor><History><Homeostasis><Human Immunodeficiency Viruses><Hybridoma Growth Factor><IFI10><IFN-Gamma><IFN-beta 2><IFN-g><IFN-γ><IFNB2><IFNG><IFNγ><IL-12><IL-15><IL-6><IL-8><IL12><IL15><IL15 Protein><IL6 Protein><IL8><IL8 gene><INP10><IP-10><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune Interferon><Immune Markers><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immune system><Immunes><Immunologic Diseases><Immunologic Markers><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Individual><Inflammaging><Inflammatory><Interferon Gamma><Interferon Type II><Interleukin-12><Interleukin-15><Interleukin-15 Precursor><Interleukin-6><Intermediary Metabolism><K lymphocyte><K60><Knowledge><LARC><LAV-HTLV-III><Length><Life Expectancy><Lymphadenopathy-Associated Virus><MGC9721><MGI-2><MIP-1><MIP3A><MOB-1><Macrophage><Macrophage Inflammatory Protein 3-Alpha><Macrophage Inflammatory Protein-1><Macrophage-Derived TNF><Maintenance><Marrow monocyte><Measures><Mediating><Membrane Potentials><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondria><Molecular><Molecular Analysis><Molecular Target><Monocyte-Derived TNF><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><NADH><NK Cells><NKSF><Natural Killer Cell Stimulatory Factor><Natural Killer Cells><Network Analysis><Niacinamide><Nicotinamide><Nicotinamidum><Nicotinic acid amide><Nicotylamide><Older Population><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Organelles><Outcome><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxygen Radicals><PBMC><PLWH><PWH><Pathway Analysis><Pathway interactions><Pellagra-Preventing Factor><Peripheral Blood Mononuclear Cell><Persons><Physiological Homeostasis><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Pro-Oxidants><Process><Production><Publishing><Race><Races><Reactive Oxygen Species><Recording of previous events><Removal><Replicative Senescence><Reporting><Resting Potentials><Reticuloendothelial System, Serum, Plasma><Risk><Role><SCYA20><SCYB10><SCYB8><Sampling><Subcellular Process><Superoxide Anion><Superoxide Radical><Superoxides><Surgical Removal><Surrogate Markers><T-Cells><T-Lymphocyte><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><TSG-1><Testing><Transmembrane Potentials><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Virus-HIV><Vitamin B 3><Vitamin B3><Vitamin PP><Vulnerable Populations><age associated><age correlated><age dependent><age linked><age related><age specific><age-related inflammation><ages><aging associated inflammation><aging biological marker><aging biomarker><aging marker><aging people with HIV><aging population with HIV><aging with HIV><aging with human immunodeficiency virus><antiretroviral therapy><antiretroviral treatment><asymptomatic HIV infection><b-ENAP><biological adaptation to stress><biological age><chronic HIV infection><cofactor><dihydronicotinamide><dinucleotide><exhaustion><experiment><experimental research><experimental study><experiments><gIP-10><histories><host response><immune function><immune senescence><immune system response><immune-based biomarkers><immunological biomarkers><immunological markers><immunoresponse><immunosenescence><improved><improved outcome><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><inflamm-ageing><inflamm-aging><inflammation associated with aging><inflammation marker><inflammatory marker><interferon beta 2><lFN-Gamma><latent HIV infection><mitochondrial><mitochondrial dysfunction><mitochondrial membrane><monocyte><multiple substance use><multisubstance use><older groups><older individuals><older person><opiate consumption><opiate drug use><opiate intake><opiate use><opiate use disorder><opioid addiction><opioid consumption><opioid dependence><opioid dependent><opioid drug use><opioid intake><opioid use><opioid use disorder><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><phenotypic biomarker><phenotypic marker><poly substance use><polysubstance use><prevent><preventing><racial><racial background><racial origin><reactioncrisis><replicative aging><resection><riboside><scRNA sequencing><scRNA-seq><senescence><senescent><sex><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stress response><stressreaction><surrogate bio-markers><surrogate biomarkers><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic outcome><therapeutic target><therapy outcome><thymus derived lymphocyte><transcriptomics><vulnerable group><vulnerable individual><vulnerable people>

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Shyamasundaran Kottilil

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$685,937

FY 2026

Project Title

Impact of opioid use disorder on mitochondrial dysfunction among antiretroviral therapy-receiving aging people with HIV.

Grant Number:

1R01DA065079-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Use of antiretroviral therapy (ART) has considerably increased life expectancy for people with HIV (PWH) resulting in increased risk of age-related non-AIDS-defining health burden, including inflammaging, a low-grade chronic proinflammatory immune response, among the older population of PWH compared...

Research Terms

<(TNF)-α><3-10C><3-Pyridinecarboxamide><AIDS Virus><AMCF-I><Abscission><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Oxygen><Adenosine><Adenosine Triphosphate><Adenylpyrophosphate><Affect><Age><Aging><Autoregulation><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cells><B-Lymphocytes><B-cell><BCDF><BSF-2><BSF2><Biochemical Process><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood monocyte><CCL20><CCL20 gene><CRG-2><CXCL10><CXCL10 gene><CXCL8><Cachectin><Calcium><Cell Aging><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cells><Cellular Aging><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Cellular Senescence><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Chemokine, CC Motif, Ligand 20><Chronic><Cytotoxic cell><Data><Dinucleoside Phosphates><Edodekin Alfa><Excision><Exodus 1><Extirpation><Fatty Acids><GCP1><General Population><General Public><Generations><Genes><HIV><HIV Seronegativities><HIV Seronegativity><HIV and aging><HIV associated aging><HIV individuals><HIV infected individuals><HIV infected persons><HIV latency><HIV negative><HIV people><HIV positive individuals><HIV positive people><HIV related aging><HPGF><HTLV-III Seronegativities><HTLV-III Seronegativity><Health><Hepatocyte-Stimulating Factor><History><Homeostasis><Human Immunodeficiency Viruses><Hybridoma Growth Factor><IFI10><IFN-Gamma><IFN-beta 2><IFN-g><IFN-γ><IFNB2><IFNG><IFNγ><IL-12><IL-15><IL-6><IL-8><IL12><IL15><IL15 Protein><IL6 Protein><IL8><IL8 gene><INP10><IP-10><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune Interferon><Immune Markers><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immune system><Immunes><Immunologic Diseases><Immunologic Markers><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Individual><Inflammaging><Inflammatory><Interferon Gamma><Interferon Type II><Interleukin-12><Interleukin-15><Interleukin-15 Precursor><Interleukin-6><Intermediary Metabolism><K lymphocyte><K60><Knowledge><LARC><LAV-HTLV-III><Length><Life Expectancy><Lymphadenopathy-Associated Virus><MGC9721><MGI-2><MIP-1><MIP3A><MOB-1><Macrophage><Macrophage Inflammatory Protein 3-Alpha><Macrophage Inflammatory Protein-1><Macrophage-Derived TNF><Maintenance><Marrow monocyte><Measures><Mediating><Membrane Potentials><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondria><Molecular><Molecular Analysis><Molecular Target><Monocyte-Derived TNF><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><NADH><NK Cells><NKSF><Natural Killer Cell Stimulatory Factor><Natural Killer Cells><Network Analysis><Niacinamide><Nicotinamide><Nicotinamidum><Nicotinic acid amide><Nicotylamide><Older Population><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Organelles><Outcome><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxygen Radicals><PBMC><PLWH><PWH><Pathway Analysis><Pathway interactions><Pellagra-Preventing Factor><Peripheral Blood Mononuclear Cell><Persons><Physiological Homeostasis><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Pro-Oxidants><Process><Production><Publishing><Race><Races><Reactive Oxygen Species><Recording of previous events><Removal><Replicative Senescence><Reporting><Resting Potentials><Reticuloendothelial System, Serum, Plasma><Risk><Role><SCYA20><SCYB10><SCYB8><Sampling><Subcellular Process><Superoxide Anion><Superoxide Radical><Superoxides><Surgical Removal><Surrogate Markers><T-Cells><T-Lymphocyte><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><TSG-1><Testing><Transmembrane Potentials><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Virus-HIV><Vitamin B 3><Vitamin B3><Vitamin PP><Vulnerable Populations><age associated><age correlated><age dependent><age linked><age related><age specific><age-related inflammation><ages><aging associated inflammation><aging biological marker><aging biomarker><aging marker><aging people with HIV><aging population with HIV><aging with HIV><aging with human immunodeficiency virus><antiretroviral therapy><antiretroviral treatment><asymptomatic HIV infection><b-ENAP><biological adaptation to stress><biological age><chronic HIV infection><cofactor><dihydronicotinamide><dinucleotide><exhaustion><experiment><experimental research><experimental study><experiments><gIP-10><histories><host response><immune function><immune senescence><immune system response><immune-based biomarkers><immunological biomarkers><immunological markers><immunoresponse><immunosenescence><improved><improved outcome><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><inflamm-ageing><inflamm-aging><inflammation associated with aging><inflammation marker><inflammatory marker><interferon beta 2><lFN-Gamma><latent HIV infection><mitochondrial><mitochondrial dysfunction><mitochondrial membrane><monocyte><multiple substance use><multisubstance use><older groups><older individuals><older person><opiate consumption><opiate drug use><opiate intake><opiate use><opiate use disorder><opioid addiction><opioid consumption><opioid dependence><opioid dependent><opioid drug use><opioid intake><opioid use><opioid use disorder><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><phenotypic biomarker><phenotypic marker><poly substance use><polysubstance use><prevent><preventing><racial><racial background><racial origin><reactioncrisis><replicative aging><resection><riboside><scRNA sequencing><scRNA-seq><senescence><senescent><sex><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stress response><stressreaction><surrogate bio-markers><surrogate biomarkers><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic outcome><therapeutic target><therapy outcome><thymus derived lymphocyte><transcriptomics><vulnerable group><vulnerable individual><vulnerable people>

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McKenna Claire Eastment

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$672,701

FY 2026

Project Title

Implementing HIV screening and prevention in low-barrier Office-Based Opioid Treatment (OBOT) programs to end the HIV epidemic

Grant Number:

1R01DA065037-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT To end the HIV epidemic (EHE), the United States aims to reduce HIV incidence by 90% by 2030. Achieving elimination of HIV will require increased efforts to screen, treat and prevent HIV among people who use drugs (PWUD). Recommended HIV prevention strategies for PWUD includ...

Research Terms

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Judith Tsui

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$672,701

FY 2026

Project Title

Implementing HIV screening and prevention in low-barrier Office-Based Opioid Treatment (OBOT) programs to end the HIV epidemic

Grant Number:

1R01DA065037-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT To end the HIV epidemic (EHE), the United States aims to reduce HIV incidence by 90% by 2030. Achieving elimination of HIV will require increased efforts to screen, treat and prevent HIV among people who use drugs (PWUD). Recommended HIV prevention strategies for PWUD includ...

Research Terms

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Amber Jarnecke

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$647,593

FY 2026

Project Title

Real-world Assessment of Social Functioning during OUD Treatment: Integrating Reports from Patients and their Concerned Significant Others

Grant Number:

5R01DA062589-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Opioid use disorder (OUD) continues to be associated with high rates of morbidity and mortality and has a significant impact on affected individuals, their families, and their communities. Problems related to social functioning are part of OUD criteria and a wealth of resear...

Research Terms

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Rachel Lynn Tomko

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$647,593

FY 2026

Project Title

Real-world Assessment of Social Functioning during OUD Treatment: Integrating Reports from Patients and their Concerned Significant Others

Grant Number:

5R01DA062589-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Opioid use disorder (OUD) continues to be associated with high rates of morbidity and mortality and has a significant impact on affected individuals, their families, and their communities. Problems related to social functioning are part of OUD criteria and a wealth of resear...

Research Terms

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Shanna Babalonis

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$647,142

FY 2026

Project Title

Impact of Cannabis on Opioid Self-Administration: Determining if Cannabis Alters the Drive to Take Opioids in Individuals with Opioid Use Disorder

Grant Number:

1R01DA062746-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract Opioid misuse is an international epidemic, with an estimated 60 million individuals misusing opioids worldwide. In the US in 2022, 6.1 million individuals met criteria for opioid use disorder and 81,083 people died due to opioid overdose. In the background of the opioid epidemic, global c...

Research Terms

<12 year old><12 years of age><Address><Advocate><American><Assay><Bioassay><Biological Assay><Cannabinoids><Cannabis><Cannabis law><Cannabis policy><Data><Decision Making><Dihydrohydroxycodeinone><Dose><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Drug usage><Drugs><Endocannabinoids><Endogenous Cannabinoids><Enrollment><Epidemic><History><Human><Incidence><Individual><Inhalation><Inhaling><Inpatients><International><Investigation><Laboratory Study><Measures><Medical><Medical Marijuana><Medication><Medicinal Marijuana><Modern Man><Opiates><Opioid><Oral><Outcome><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Pain><Painful><Participant><Persons><Pharmaceutical Preparations><Physical Dependence><Physiologic><Physiological><Placebo Control><Prevalence><Provincial Government><Public Health><Qualifying><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized><Recommendation><Recording of previous events><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Risk><Roxicodone><Safety><Sampling><Self Administered><Self Administration><State Government><THC co-use><THC use><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Therapeutic><Time><Translating><US State><Vulnerable Populations><abuse liability><abuse potential><age 12><age 12 years><cannabis regulation><cannabis self-administration><cannabis use><cannabis use disorder><cannabis use law><cannabis use policy><cannabis user><clinical practice><design><designing><drug misuse><drug use><drug/agent><enroll><epidemiology research study><epidemiology study><epidemiology survey><health data><high risk><high risk group><high risk individual><high risk people><high risk population><histories><marijuana law><marijuana policy><marijuana use><marijuana use and disorder><marijuana use disorder><marijuana user><medical cannabis><medication misuse><medicinal cannabis><mortality><non-medical opioid use><non-medical use><nonmedical opioid use><nonmedical use><novel><opiate abuse><opiate consumption><opiate crisis><opiate drug abuse><opiate drug use><opiate intake><opiate misuse><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid abuse><opioid consumption><opioid crisis><opioid drug abuse><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid misuse><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><overdose death><overdose fatalities><oxycodone self-administration><pain patient><placebo controlled><public health relevance><randomisation><randomization><randomized placebo controlled study><randomly assigned><response><risk mitigation><secondary outcome><self-administer oxycodone><therapeutic cannabis><therapeutic marijuana><twelve year old><twelve years of age><virtual><vulnerable group><vulnerable individual><vulnerable people>

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Andrew A Herring

RAND CORPORATION, SANTA MONICA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$625,037

FY 2026

Project Title

Reducing Overdose and Suicide Risk in Individuals with OUD and Co-occurring Disorders

Grant Number:

5R01DA056588-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT Suicide and overdose deaths are at record levels, and the Emergency Department (ED) is at the forefront of delivering care to those at the highest risk. Opioid use disorders (OUD) and mental illness are major contributors to both. In 2017 nearly half of suicide and overdose deaths w...

Research Terms

<21+ years old><Accident and Emergency department><Address><Adult><Adult Human><Ambulatory Care><Buprenorphine><California><Caring><Cessation of life><Data><Death><Death Rate><Deliberate Self-Harm><Development><Disease><Disorder><Dose><ED care><ED visit><ER care><ER visit><Emergency Care><Emergency Department><Emergency Department care><Emergency Room care><Emergency Therapy><Emergency care visit><Emergency department visit><Emergency health care><Emergency hospital visit><Emergency medical care><Emergency room><Emergency room visit><Emergency treatment><Enrollment><Epidemic><Event><Goals><Heterogeneity><High Prevalence><History><Hospitals><Individual><Intervention><Link><Location><Measures><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Modeling><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Nature><Out-patients><Outpatient Care><Outpatients><Overdose><Overdose reduction><Patient Care><Patient Care Delivery><Patients><Persons><Population><Provider><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Recording of previous events><Research><Research Resources><Resources><Risk><Self-Injurious Behavior><Sequential Multiple Assignment Randomized Trial><Services><Sight><Specific qualifier value><Specified><Suicide><Suicide attempt><Test Result><Testing><Time><Treatment outcome><Vision><acute care><adaptive intervention><addiction><addictive disorder><adulthood><behavioral health><bridge program><care for patients><care of patients><caring for patients><co-morbid><co-morbidity><co-occurring disorders><collaborative care><comorbidity><death risk><deliberate self harm><developmental><dual diagnosis><enroll><evidence base><fatal attempt><fatal suicide><high risk><histories><improved><innovate><innovation><innovative><intent to die><intentional self harm><intentional self injury><intervention delivery><medical complication><medication for opioid use disorder><mental illness><mortality><mortality rate><mortality risk><non fatal attempt><nonfatal attempt><opiate consumption><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><outpatient treatment><overdose death><overdose fatalities><overdose risk><participant engagement><patient engagement><premature><prematurity><prevent><preventing><primary outcome><psychiatric illness><psychological disorder><reduce overdose><reduction in overdose><relapse risk><response><response to therapy><response to treatment><secondary outcome><self harm><self injury><service delivery><substance use><substance using><suicidal attempt><suicidal morbidity><suicidal mortality><suicidal risk><suicide death><suicide morbidity><suicide mortality><suicide risk><suicides><telehealth><therapeutic response><therapy response><treatment response><treatment responsiveness><visual function>

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Mariah M Kalmin

RAND CORPORATION, SANTA MONICA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$625,037

FY 2026

Project Title

Reducing Overdose and Suicide Risk in Individuals with OUD and Co-occurring Disorders

Grant Number:

5R01DA056588-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT Suicide and overdose deaths are at record levels, and the Emergency Department (ED) is at the forefront of delivering care to those at the highest risk. Opioid use disorders (OUD) and mental illness are major contributors to both. In 2017 nearly half of suicide and overdose deaths w...

Research Terms

<21+ years old><Accident and Emergency department><Address><Adult><Adult Human><Ambulatory Care><Buprenorphine><California><Caring><Cessation of life><Data><Death><Death Rate><Deliberate Self-Harm><Development><Disease><Disorder><Dose><ED care><ED visit><ER care><ER visit><Emergency Care><Emergency Department><Emergency Department care><Emergency Room care><Emergency Therapy><Emergency care visit><Emergency department visit><Emergency health care><Emergency hospital visit><Emergency medical care><Emergency room><Emergency room visit><Emergency treatment><Enrollment><Epidemic><Event><Goals><Heterogeneity><High Prevalence><History><Hospitals><Individual><Intervention><Link><Location><Measures><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Modeling><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Nature><Out-patients><Outpatient Care><Outpatients><Overdose><Overdose reduction><Patient Care><Patient Care Delivery><Patients><Persons><Population><Provider><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Recording of previous events><Research><Research Resources><Resources><Risk><Self-Injurious Behavior><Sequential Multiple Assignment Randomized Trial><Services><Sight><Specific qualifier value><Specified><Suicide><Suicide attempt><Test Result><Testing><Time><Treatment outcome><Vision><acute care><adaptive intervention><addiction><addictive disorder><adulthood><behavioral health><bridge program><care for patients><care of patients><caring for patients><co-morbid><co-morbidity><co-occurring disorders><collaborative care><comorbidity><death risk><deliberate self harm><developmental><dual diagnosis><enroll><evidence base><fatal attempt><fatal suicide><high risk><histories><improved><innovate><innovation><innovative><intent to die><intentional self harm><intentional self injury><intervention delivery><medical complication><medication for opioid use disorder><mental illness><mortality><mortality rate><mortality risk><non fatal attempt><nonfatal attempt><opiate consumption><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><outpatient treatment><overdose death><overdose fatalities><overdose risk><participant engagement><patient engagement><premature><prematurity><prevent><preventing><primary outcome><psychiatric illness><psychological disorder><reduce overdose><reduction in overdose><relapse risk><response><response to therapy><response to treatment><secondary outcome><self harm><self injury><service delivery><substance use><substance using><suicidal attempt><suicidal morbidity><suicidal mortality><suicidal risk><suicide death><suicide morbidity><suicide mortality><suicide risk><suicides><telehealth><therapeutic response><therapy response><treatment response><treatment responsiveness><visual function>

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Katherine E Watkins

RAND CORPORATION, SANTA MONICA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$625,037

FY 2026

Project Title

Reducing Overdose and Suicide Risk in Individuals with OUD and Co-occurring Disorders

Grant Number:

5R01DA056588-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT Suicide and overdose deaths are at record levels, and the Emergency Department (ED) is at the forefront of delivering care to those at the highest risk. Opioid use disorders (OUD) and mental illness are major contributors to both. In 2017 nearly half of suicide and overdose deaths w...

Research Terms

<21+ years old><Accident and Emergency department><Address><Adult><Adult Human><Ambulatory Care><Buprenorphine><California><Caring><Cessation of life><Data><Death><Death Rate><Deliberate Self-Harm><Development><Disease><Disorder><Dose><ED care><ED visit><ER care><ER visit><Emergency Care><Emergency Department><Emergency Department care><Emergency Room care><Emergency Therapy><Emergency care visit><Emergency department visit><Emergency health care><Emergency hospital visit><Emergency medical care><Emergency room><Emergency room visit><Emergency treatment><Enrollment><Epidemic><Event><Goals><Heterogeneity><High Prevalence><History><Hospitals><Individual><Intervention><Link><Location><Measures><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Modeling><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Nature><Out-patients><Outpatient Care><Outpatients><Overdose><Overdose reduction><Patient Care><Patient Care Delivery><Patients><Persons><Population><Provider><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Recording of previous events><Research><Research Resources><Resources><Risk><Self-Injurious Behavior><Sequential Multiple Assignment Randomized Trial><Services><Sight><Specific qualifier value><Specified><Suicide><Suicide attempt><Test Result><Testing><Time><Treatment outcome><Vision><acute care><adaptive intervention><addiction><addictive disorder><adulthood><behavioral health><bridge program><care for patients><care of patients><caring for patients><co-morbid><co-morbidity><co-occurring disorders><collaborative care><comorbidity><death risk><deliberate self harm><developmental><dual diagnosis><enroll><evidence base><fatal attempt><fatal suicide><high risk><histories><improved><innovate><innovation><innovative><intent to die><intentional self harm><intentional self injury><intervention delivery><medical complication><medication for opioid use disorder><mental illness><mortality><mortality rate><mortality risk><non fatal attempt><nonfatal attempt><opiate consumption><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><outpatient treatment><overdose death><overdose fatalities><overdose risk><participant engagement><patient engagement><premature><prematurity><prevent><preventing><primary outcome><psychiatric illness><psychological disorder><reduce overdose><reduction in overdose><relapse risk><response><response to therapy><response to treatment><secondary outcome><self harm><self injury><service delivery><substance use><substance using><suicidal attempt><suicidal morbidity><suicidal mortality><suicidal risk><suicide death><suicide morbidity><suicide mortality><suicide risk><suicides><telehealth><therapeutic response><therapy response><treatment response><treatment responsiveness><visual function>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Veronica A Alvarez

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$616,630

FY 2026

Project Title

Single-Cell Dissection of Ensembles and Cell Types Mediating Opioid Action in the Rodent Brain

Grant Number:

5R01DA054584-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2021

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Substance use disorder (SUD) is a debilitating condition characterized by compulsive use of a substance, in spite of the subjective recognition of the drawbacks associated with its use. Chronic use of the substance leads to the development of withdrawal and dependence, hindering intentional controls...

Research Terms

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Myriam Heiman

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$616,630

FY 2026

Project Title

Single-Cell Dissection of Ensembles and Cell Types Mediating Opioid Action in the Rodent Brain

Grant Number:

5R01DA054584-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2021

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Substance use disorder (SUD) is a debilitating condition characterized by compulsive use of a substance, in spite of the subjective recognition of the drawbacks associated with its use. Chronic use of the substance leads to the development of withdrawal and dependence, hindering intentional controls...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Manolis Kellis

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$616,630

FY 2026

Project Title

Single-Cell Dissection of Ensembles and Cell Types Mediating Opioid Action in the Rodent Brain

Grant Number:

5R01DA054584-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2021

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Substance use disorder (SUD) is a debilitating condition characterized by compulsive use of a substance, in spite of the subjective recognition of the drawbacks associated with its use. Chronic use of the substance leads to the development of withdrawal and dependence, hindering intentional controls...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Gabriel G Haddad

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$611,277

FY 2026

Project Title

Effect of methadone on the developmental properties of human brain organoids

Grant Number:

5R01DA053372-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT The opioid crisis has become a national epidemic and the statistics are startling. In the past decade there has been a sharp increase in heroin use, opiate prescriptions and fentanyl abuse. Overdose deaths have doubled nationally since 2000 and in 2015, and more than 33,000 deaths were att...

Research Terms

<3-D><3-Dimensional><3D><Actiq><Adanon><Address><Affect><Althose><Astrocytes><Astrocytus><Astroglia><Blood><Blood Reticuloendothelial System><Brain><Brain Nervous System><Buprenorphine><Cessation of life><Cognitive><D-Glucose><Data><Death><Dendritic Spines><Dependence><Developing fetus><Development><Dextrose><Diacetylmorphine><Diamorphine><Disease><Disorder><Dolophine><Drug abuse><Duragesic><ED visit><ER visit><Electrophysiology><Electrophysiology (science)><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><Encephalon><Endocrine Gland Secretion><Epidemic><Ethics><Fentanest><Fentanyl><Fentyl><Fetal Development><Fetus><Genetic><Gestation><Glucose><Glycoproteins><Heroin><Hormones><Human><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><Investigation><Life><Maternal Exposure><Membrane><Methadone><Methadose><Methods><Modern Man><Molecular><Morbidity><Mothers><Neonatal Abstinence Syndrome><Neonatal Opioid Withdrawal Syndrome><Neonatal Substance Withdrawal><Neonatal Withdrawal Syndrome><Nerve Cells><Nerve Unit><Neural Cell><Neural Transmission><Neurites><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Organoids><Patch-Clamp Technics><Patch-Clamp Techniques><Pattern><Phentanyl><Pregnancy><Pregnant Women><Property><Receptor Protein><Regulation><Societies><Structure><Synapses><Synaptic><Synaptic Transmission><Synaptic plasticity><TSP-1><TSP1><Techniques><Therapeutic Hormone><Thrombospondin 1><Youth><Youth 10-21><abuse of drugs><abuses drugs><astrocytic glia><dendrite spine><developmental><electrophysiological><ethical><excitatory neuron><expectant mother><expectant women><expecting mother><expecting women><fentanyl abuse><fetal><gestational opioid use><heroin intake><heroin use><human fetal brain><imaging study><in utero><individuals who are pregnant><inhibitory neuron><licit opioid><maternal opiates use><maternal opioid use><membrane structure><mortality><multi-electrode arrays><multidrug use><multielectrode arrays><multiple drug use><neural network><neuronal><new drug target><new druggable target><new pharmacotherapy target><new technology><new therapeutic target><new therapy target><newborn abstinence syndrome><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel technologies><novel therapeutic target><novel therapy target><offspring><opiate abuse><opiate crisis><opiate drug abuse><opiate exposure><opiate medication><opiate overdose><opiate related overdose><opiate use in pregnancy><opioid abuse><opioid addiction><opioid crisis><opioid dependence><opioid dependent><opioid drug abuse><opioid drug overdose><opioid epidemic><opioid exposure><opioid induced overdose><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use in pregnancy><opioids during pregnancy><opioids in pregnancy><opoid use during pregnancy><overdose death><overdose fatalities><patch clamp><people who are pregnant><poly drug use><polydrug use><postsynaptic><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal opioid use><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><presynaptic><productivity loss><receptor><statistics><synapse><synapse formation><synapse function><synaptic function><synaptogenesis><those who are pregnant><three dimensional><women who are pregnant><youth age>

View Full Project Details on NIH Reporter

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YAN XU

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$600,220

FY 2026

Project Title

Peripheral and Central Pathways of α3 Glycine Receptors as Non-Opioid Molecular Targets to Treat Pain

Grant Number:

5R01NS122830-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Over 100 million Americans experience some forms of physical pain, a quarter of whom struggle daily to cope with chronic and persistent pain conditions. One of the risks associated with existing analgesic drugs, beyond some manageable side effects, is the potential for drug dependence and abuse. Gly...

Research Terms

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Kara Elizabeth Rudolph

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$594,657

FY 2026

Project Title

Role of disability and pain in opioid overdose: mechanism and risk mitigation

Grant Number:

5R01DA053243-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Drug overdose deaths in the US have increased exponentially, driven by opioid overdoses. Concurrently, US surveillance studies have documented increased disability prevalence among adults in midlife. People with disabilities have higher rates of opioid use disorder (OUD) but are less likely to recei...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Affordable Care Act><After Care><After-Treatment><Aftercare><Benzodiazepine Compounds><Benzodiazepines><Cessation of life><Chronic><Confounding Factors (Epidemiology)><Confounding Variables><County><Death><Deaths of despair><Disabilities experience><Disabled Persons><Disabled Population><Disease Management><Disorder Management><Drugs><Economics><Eligibility><Eligibility Determination><Epidemiologic Confounding Factor><Exclusion><Exposure to><Future><Geography><Goals><Handicapped><High Prevalence><Hospital Admission><Hospitalization><Individuals with physical disabilities><Injury><Insurance><Intervention><Joints><Left><Link><Literature><Low income><Machine Learning><Mediating><Mediation><Mediator><Medicaid><Medication><Mental Depression><Methods><Musculoskeletal><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Negotiating><Negotiation><Obamacare><Opiates><Opioid><Opioid Analgesics><Outcome><Overdose><Overdose reduction><Pain><Pain Control><Pain Therapy><Pain management><Painful><Pathway interactions><People with Disabilities><Persons with Disabilities><Persons with Physical Disabilities><Pharmaceutical Preparations><Population><Practice Management><Prevalence><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Probability><Property><Protocol Screening><Qualifying><Recommendation><Research><Risk><Risk Reduction><Role><Statistical Methods><Stimulant><Subgroup><Substance Use Disorder><Vulnerable Populations><adulthood><attributable risk><beneficiary><chronic pain><chronic pain condition><chronic pain control><chronic pain disorder><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><chronic painful condition><co-morbid><co-morbidity><comorbidity><depression><disability><disabled><disabled individual><disabled people><drug/agent><economic><geographic difference><geographic variation><high risk><improved><indexing><individuals with disabilities><injuries><licit opioid><machine based learning><mid life><mid-life><middle age><middle aged><midlife><multi-modality><multimodality><non-cancer pain><non-medical opioid use><noncancer pain><nonmedical opioid use><novel><opiate analgesia><opiate analgesic><opiate crisis><opiate medication><opiate misuse><opiate overdose><opiate pain medication><opiate pain reliever><opiate related overdose><opiate use disorder><opioid analgesia><opioid anesthetic><opioid crisis><opioid drug overdose><opioid epidemic><opioid induced overdose><opioid intoxication><opioid medication><opioid medication overdose><opioid misuse><opioid overdose><opioid pain medication><opioid pain reliever><opioid painkiller><opioid poisoning><opioid related overdose><opioid toxicity><opioid use disorder><overdose death><overdose fatalities><overdose risk><pain intervention><pain treatment><pathway><physical disability><physically disabled><physically handicapped><post treatment><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><reduce overdose><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><reduction in overdose><risk mitigation><risk-reducing><social role><statistic methods><stressor><substance use><substance use and disorder><substance use treatment><substance using><surveillance study><treat chronic pain><vulnerable group><vulnerable individual><vulnerable people>

View Full Project Details on NIH Reporter

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Justin Charles Strickland

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$593,386

FY 2026

Project Title

Influence of Orexin Antagonism on Methamphentamine Demand

Grant Number:

7R01DA055634-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY ABSTRACT Deemed a “Twin Epidemic” or “Fourth Wave”, epidemiological evidence emphasizes rapidly increasing public health harms of methamphetamine use among people who use opioids. These data are particularly worrisome given there are no FDA approved pharmacotherapies for methamphetam...

Research Terms

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Lorraine I Kelley-Quon

CHILDREN'S HOSPITAL OF LOS ANGELES, LOS ANGELES, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$590,678

FY 2026

Project Title

The Impact of Opioids on Health Outcomes for Hospitalized Infants

Grant Number:

5R01HD105656-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Caring for hospitalized infants requires a comprehensive pain control program aimed at reducing and preventing pain. While opioids are commonly used when an infant undergoes a painful procedure, opioids can increase the risk of short- and long-term morbidity. The duration and type of...

Research Terms

<0-11 years old><Acquired brain injury><Actiq><Acute><Adanon><Address><Admission><Admission activity><Althose><Birth Weight><Brain Dead><Brain Death><Brain Injuries><California><Cardiac Malformation><Caring><Cessation of life><Child><Child Development Disorders><Child Youth><Childhood><Children (0-21)><Children's Hospital><Clinical><Clinical Data><Clinical Protocols><Cognitive><Coma Depasse><Cost Analyses><Cost Analysis><Critical Illness><Critically Ill><Data><Data Bases><Data Set><Databases><Death><Dedications><Dependence><Development><Developmental Disabilities><Dihydromorphinone><Dilaudid><Dilaudid HP><Dimorphone><Dolophine><Dose><Drugs><Duragesic><Exposure to><Extracorporeal Membrane Oxygenation><Fentanest><Fentanyl><Fentyl><Gestation><Goals><HEAL Initiative><Health><Health Care Utilization><Health Information System><Health Policy><Heart Malformation><Helping End Addiction Long-term><Helping to End Addiction Long-term><Hormonal><Hospital Admission><Hospitalization><Hospitals><Hydromorphon><Hydromorphone><Hydrostat><Hymorphan><Infant><Infumorph><Institution><Intervention><Intravenous Feeding><Intravenous Hyperalimentation><Kadian><Language><Laudacon><Laudicon><Length of Stay><Link><Long-term Follow-up><MS Contin><MSir><Medication><Methadone><Methadose><Morbidity><Morphia><Morphine><Motor disability><NIH><National Institutes of Health><Necrotizing Enterocolitis><Neonatal><Neonatal Abstinence Syndrome><Neonatal Opioid Withdrawal Syndrome><Neonatal Substance Withdrawal><Neonatal Withdrawal Syndrome><Neural Development><Neurocognitive><Neurodevelopmental Disability><Neurologic><Neurological><Novolauden><Number of Days in Hospital><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Oramorph><Oramorph SR><Outcome><Pain><Pain Control><Pain Therapy><Pain management><Painful><Parenteral Feedings><Parenteral Nutrition><Pediatric Hospitals><Perinatal><Peripartum><Pharmaceutical Preparations><Pharmacies><Pharmacy facility><Phentanyl><Physiologic><Physiological><Policy Maker><Population><Population Heterogeneity><Pregnancy><Procedures><Public Health><QOC><Quality of Care><Regression Analyses><Regression Analysis><Regression Diagnostics><Research><Research Resources><Resources><Risk><Roxanol><Shapes><Statex SR><Statistical Regression><Surgical><Surgical Interventions><Surgical Procedure><Survivors><Time><United States><United States National Institutes of Health><Variant><Variation><Ventilator><Weight><abnormal heart development><assess cost><brain damage><brain-injured><cardiovascular risk><cardiovascular risk factor><care costs><cerebral death><co-morbid><co-morbidity><cohort><comorbidity><compare cost><congenital cardiac abnormality><congenital cardiac anomalies><congenital cardiac disease><congenital cardiac disorder><congenital cardiac malformation><congenital heart abnormality><congenital heart anomaly><congenital heart disease><congenital heart disorder><congenital heart malformation><cost assessment><cost comparison><cost evaluation><data base><developmental><differences in health><disability><diverse populations><drug/agent><early childhood><evaluate cost><examine cost><experience><health care policy><health care service use><health care service utilization><health difference><heterogeneous population><high risk infant><hospital days><hospital length of stay><hospital stay><hyperalimentation><hyperalimentation therapy><impaired brain development><improved><infancy><infantile><instrument><kids><licit opioid><long-term followup><longitudinal data set><longitudinal dataset><morphine equivalence><morphine equivalent><neonatal care><neurodevelopment><newborn abstinence syndrome><novel><opiate abuse><opiate consumption><opiate drug abuse><opiate drug use><opiate exposure><opiate intake><opiate medication><opiate use><opioid abuse><opioid consumption><opioid drug abuse><opioid drug use><opioid exposure><opioid intake><opioid medication><opioid use><pain intervention><pain treatment><pediatric><population diversity><prenatal><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent><preventing><programs><response><surgery><unborn><vulnerable infant><weights><youngster>

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Jessica Ann Chen

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$588,311

FY 2026

Project Title

Assessing the influence of pandemic-era policies on patterns of opioid use disorder care in a national veteran population

Grant Number:

5R01DA056232-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Opioid use disorder (OUD) is a prevalent and often life-threatening condition that can be effectively managed with medication-based treatment (MOUD). First-line therapies such as methadone and buprenorphine are known to reduce the risk of overdose and support long-term recovery. However, access to b...

Research Terms

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Emily Caterina Williams

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$588,311

FY 2026

Project Title

Assessing the influence of pandemic-era policies on patterns of opioid use disorder care in a national veteran population

Grant Number:

5R01DA056232-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Opioid use disorder (OUD) is a prevalent and often life-threatening condition that can be effectively managed with medication-based treatment (MOUD). First-line therapies such as methadone and buprenorphine are known to reduce the risk of overdose and support long-term recovery. However, access to b...

Research Terms

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ARPANA AGRAWAL

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$577,531

FY 2026

Project Title

A Multiomic Single Nucleus RNA-seq and ATAC-seq Examination of Key Brainstem Respiratory Control Regions from Fentanyl Overdose Decedents with and without Xylazine Present, and Matched Controls

Grant Number:

1R01DA063124-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Over 81,000 individuals died of an opioid overdose (OD) in 2023, and >92% of those cases involved fentanyl. Fentanyl has very potent opioid-induced respiratory depression (OIRD) effects, the primary cause of opioid OD death. Key brainstem regions, the preBötzinger complex and ventral respiratory gro...

Research Terms

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ELLIOT C NELSON

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$577,531

FY 2026

Project Title

A Multiomic Single Nucleus RNA-seq and ATAC-seq Examination of Key Brainstem Respiratory Control Regions from Fentanyl Overdose Decedents with and without Xylazine Present, and Matched Controls

Grant Number:

1R01DA063124-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Over 81,000 individuals died of an opioid overdose (OD) in 2023, and >92% of those cases involved fentanyl. Fentanyl has very potent opioid-induced respiratory depression (OIRD) effects, the primary cause of opioid OD death. Key brainstem regions, the preBötzinger complex and ventral respiratory gro...

Research Terms

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CATHERINE M CAHILL

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$554,896

FY 2026

Project Title

Amygdala kappa opioid system involvement in opioid relapse in pain states

Grant Number:

5R01DA053752-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Chronic pain is second only to bipolar disorder as the major cause of suicide among all medical illnesses, where prevalence of depression ranges between 30 to 80%. The importance of this negative affect is reflected in studies that show co-existing psychopathology increases pain intensity, ...

Research Terms

<ACTH-Releasing Factor><Address><Affective><Alcohol Drinking><Alcohol consumption><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anhedonia><Animals><Anxiety><Attenuated><Behavior><Bipolar Affective Psychosis><Bipolar Disorder><Brain region><CRF-41><Cell Nucleus><Central Lateral Nucleus><Central Lateral Thalamic Nucleus><Chronic><Consumption><Corticoliberin><Corticotropin-Releasing Factor><Corticotropin-Releasing Factor-41><Corticotropin-Releasing Hormone><Corticotropin-Releasing Hormone-41><Data><Development><Drug Exposure><Drugs><Dynorphins><Emotional><EtOH drinking><EtOH use><Exhibits><Extinction><Fiber><Genetic><Genetic Models><Heavy Drinking><Hypothalamic structure><Hypothalamus><IRES><Internal Ribosome Entry Segment><Internal Ribosome Entry Site><Intravenous><Lead><Learning><Ligands><Long-term pain><Manic-Depressive Psychosis><Mediating><Medical><Medical Records><Medication><Medulla Spinalis><Mental Depression><Mental disorders><Mental health disorders><Messenger RNA><Mice><Mice Mammals><Modeling><Murine><Mus><Negative Reinforcements><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nociception><Nucleus><Opiate Addiction><Opiate Antagonist><Opiate Dependence><Opiate agonist><Opiate receptor agonist><Opiate receptor antagonist><Opiates><Opioid><Opioid Antagonist><Opioid agonist><Opioid receptor agonist><Opioid receptor antagonist><Pain><Pain Disorder><Pain intensity><Painful><Patients><Pb element><Persistent pain><Pharmaceutical Preparations><Photometry><Predisposition><Prevalence><Process><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Psychopathology><R-Series Research Projects><R01 Mechanism><R01 Program><RT-PCR><Receptor Activation><Receptor Signaling><Receptor Up-Regulation><Relapse><Reporting><Research Grants><Research Project Grants><Research Projects><Reverse Transcriptase Polymerase Chain Reaction><Rewards><Ribosome Entry Site><Risk Factors><Rodent Model><Self Administered><Self Administration><Sensory><Spinal Cord><Stimulus><Stress><Suicide><Susceptibility><System><Testing><Time><abnormal psychology><addiction><addictive disorder><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><amygdaloid nuclear complex><animal pain><attenuate><attenuates><biological adaptation to stress><bipolar affective disorder><bipolar disease><bipolar illness><bipolar mood disorder><chronic pain><chronic pain patient><constant pain><corticotropin releasing hormone><deficits in reward learning><depression><developmental><disabling pain><drink heavily><drug relapse><drug seeking behavior><drug withdrawal><drug/agent><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><experience><extreme drinking><fatal attempt><fatal suicide><genetic approach><genetic strategy><heavy alcohol use><heavy metal Pb><heavy metal lead><hypothalamic><in vivo><intent to die><intravenous opiate><intravenous opioid><kappa opiate><kappa opioid><kappa opioid receptors><lasting pain><licit opioid><mRNA><manic depressive disorder><manic depressive illness><mental illness><motivated behavior><mouse model><murine model><negative affect><negative affectivity><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><nociceptive><non-medical opioid use><nonmedical opioid use><nor-BNI><nor-binaltorphimine><norbinaltorphimine><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><on-going pain><ongoing pain><opiate crisis><opiate injection><opiate medication><opiate misuse><opiate overdose><opiate related overdose><opiate use disorder><opioid addiction><opioid crisis><opioid dependence><opioid dependent><opioid drug overdose><opioid epidemic><opioid induced overdose><opioid injection><opioid injector><opioid intoxication><opioid medication><opioid medication overdose><opioid misuse><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use disorder><pain-related disability><parabrachial nucleus><patient with chronic pain><pharmacologic><pre-clinical><preclinical><preference><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><psychiatric illness><psychological disorder><reactioncrisis><receptor expression><receptor function><receptor upregulation><reverse transcriptase PCR><reward circuit dysfunction><reward dysfunction><reward system dysfunction><sensory input><stress response><stressreaction><suicides><therapeutic opioid><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR>

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Brian K Kobilka

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$543,386

FY 2026

Project Title

The structural basis for pathway-selective signaling by the µ opioid receptor

Grant Number:

5R01DA036246-11

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2013

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract The structural basis for pathway-selective signaling by the µ-opioid receptor. For many patients experiencing acute and chronic pain, opioids like codeine, morphine, and fentanyl have improved their quality of life. Unfortunately, these benefits can be offset by dose-limitin...

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Daniel Charles Castro

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$523,855

FY 2026

Project Title

Investigating non-canonical mechanisms of endogenous opioids on motivation in dorsal midbrain

Grant Number:

5R01MH132504-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/9/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The primary goal of this R01 is to determine the computational and functional role of endogenous opioids in specific dorsal midbrain nuclei on motivated behaviors. The preponderance of mental illness in the United States results in tens of millions of dollars in healthcare costs. Whi...

Research Terms

<21+ years old><Active Follow-up><Adult><Adult Human><Affect><Affective><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anatomic Sites><Anatomic structures><Anatomy><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Appetite><Appetite stimulated><Behavior><Behavioral><Biological><Bite><Brain><Brain Nervous System><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Calcium><Cas nuclease technology><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Characteristics><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Color><Data><Desire for food><Devices><Dissociation><Dorsal><E-stim><Eating><Electric Stimulation><Encephalon><Endoscopy><Enkephalin Receptors><Enkephalins><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Food Intake><Genetic><Goals><Health Care Costs><Health Costs><Image><Increased food appetite><Individual><Infumorph><Intracellular Communication and Signaling><Kadian><Lateral><Ligands><MS Contin><MSir><Measures><Mediating><Mental disorders><Mental health disorders><Mesencephalic Central Gray><Mesencephalon><Mice><Mice Mammals><Microinjections><Mid-brain><Midbrain><Midbrain Central Gray><Midbrain structure><Moods><Morphia><Morphine><Motivation><Murine><Mus><NIMH><National Institute of Mental Health><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nucleus><Nucleus Accumbens><Opiate Peptides><Opiate Receptors><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid Peptide><Opioid Receptor><Opioid agonist><Opioid receptor agonist><Opsin><Oramorph><Oramorph SR><Pattern><Peptides><Periaqueductal Gray><Pharmacology><Phenotype><Photons><Pilot Projects><Play><Process><Psychiatric Disease><Psychiatric Disorder><Receptor Protein><Regulation><Rewards><Rod-Opsin><Role><Roxanol><Signal Transduction><Signal Transduction Systems><Signaling><Site><Statex SR><Strategic Planning><System><Tail><Technology><Testing><Therapeutic Intervention><United States><Virus><active followup><adulthood><annulus of the aqueduct><antagonism><antagonist><behavior test><behavioral test><biologic><biological adaptation to stress><biological signal transduction><calcium indicator><cell type><delta opioid receptor><design><designing><dorsal raphe nucleus><electrostimulation><endogenous opiate><endogenous opioids><endoscopic imaging><experience><experiment><experimental research><experimental study><experiments><fluorophore><follow up><follow-up><followed up><followup><imaging><imaging in vivo><in vivo imaging><increased appetite><increased hunger><insight><intervention therapy><knock-down><knockdown><mental illness><midbrain central gray substance><motivated behavior><mu receptors><neural><neural circuit><neural circuitry><neural control><neural regulation><neurobiological mechanism><neurochemical><neurochemistry><neurocircuitry><neuromodulation><neuromodulatory><neuronal><neuropsychiatric><neuropsychiatric disease><neuropsychiatric disorder><neuropsychiatry><neuroregulation><next generation><optogenetics><pain killer><pain medication><pain reliever><painkiller><periaqueductal gray matter><pharmacologic><pilot study><psychiatric illness><psychological disorder><reactioncrisis><receptor><receptor expression><redshift><response><social role><stress response><stressreaction><synaptic circuit><synaptic circuitry><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><wireless><wireless implant><δ OR><δ ORs><δ opioid receptors><δ-OR><δ-ORs><δOR><δORs><μ receptors>

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Jose A Moron-Concepcion

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$521,516

FY 2026

Project Title

Dissecting the role of dorsal hippocampus to nucleus accumbens circuits in opioid seeking behavior

Grant Number:

5R01DA058613-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Although significant advances in the treatment of opiate addiction have been made, relapse to opiate use after abstinence continues to impede successful treatment, highlighting the need for efforts to dissect the mechanism of opiate-dependent changes in brain function. Long-lasting associations betw...

Research Terms

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MEI-CHUAN KO

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$518,766

FY 2026

Project Title

Buprenorphine analogs for the treatment of opioid abuse

Grant Number:

7R01DA053343-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2021

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The recent marked increase in misuse and abuse of opioids and the epidemic of opioid overdose mortality have greatly affected our society. Given that non-human primate models offer the most phylogenetically appropriate evaluation of opioid receptor functions and drug effects, the goa...

Research Terms

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Martin Kaczocha

STATE UNIVERSITY NEW YORK STONY BROOK, STONY BROOK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$504,415

FY 2026

Project Title

FABP5: Novel Functions in Pain Modulation

Grant Number:

5R01NS137595-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Chronic pain is widespread in the adult population and inadequate pain control has a major negative impact on the quality of life of chronic pain sufferers. Many currently available analgesics display modest efficacy and in the case of opioids, addiction liability that has resulted i...

Research Terms

<21+ years old><ANK1><ANK1 gene><Absence of pain sensation><Absence of sensibility to pain><Adult><Adult Human><Affect><Afferent Neurons><Affinity><Anabolism><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Ankyrin 1><Anodynes><Antibodies><Antinociceptive Agents><Antinociceptive Drugs><Apoptosis-Related Cysteine Protease Caspase 1><BLT1><BLTR><Behavior><Behavioral><Binding><Binding Sites><Biologic Sciences><Biological><Biological Function><Biological Process><Biological Sciences><Bioscience><Body Tissues><CASP-1><CASP1><CASP1 gene><CMKRL1><CNS Nervous System><Calcium><Cannabinoids><Carrier Proteins><Caspase-1><Caspase-1 Gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell secretion><Cells><Cellular Secretion><Central Nervous System><Chaperone><Chemotactic Cytokines><Clinical Evaluation><Clinical Testing><Combining Site><Development><Dorsal Root Ganglia><Eicosanoids><Electrophysiology><Electrophysiology (science)><Endocannabinoids><Endogenous Cannabinoids><Enzyme Gene><Enzymes><Family><Feels no pain><Foundations><Future><G Protein-Coupled Receptor 16><GPR16><Homolog of Drosophila TOLL><Homologous Chemotactic Cytokines><Hyperalgesia><Hyperalgesic Sensations><Hypersensitivity><ICE Protease><IL-1 beta Convertase><IL-1 beta-Converting Enzyme><IL-1BC><IL-1b Converting Enzyme><IL1B-Convertase><IL1BC><IL1BCE><Image><Immune><Immunes><In Vitro><Inflammation><Inflammatory><Intercrines><Interleukin 1-B Converting Enzyme><Interleukin 1-Beta Convertase><Interleukin-1 Beta Converting Enzyme><Interleukin-1 Converting Enzyme><Intracellular Communication and Signaling><KO mice><Knock-out Mice><Knockout Mice><Knowledge><LTB4><LTB4 Receptors><LTB4R><LTB4R gene><LTB4R1><Lead><Leukotriene B-4><Leukotriene B4><Leukotriene B4 G Protein-Coupled Receptor><Leukotriene B4 Receptor><Leukotriene B4 Receptors><Leukotrienes><Life Sciences><Ligand Binding><Link><Lipid Trafficking><Lipids><Mediating><Mediator><Mice><Mice Mammals><Molecular Chaperones><Molecular Interaction><Murine><Mus><Myelogenous><Myeloid><Myeloid Cells><N arachidonoyl 2 hydroxyethylamide><N-arachidonoylethanolamine><N-palmitoylethanolamine><NSAIDs><Nerve Cells><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neurons><Neurophysiology / Electrophysiology><No sensitivity to pain><Nociception><Nociceptors><Non-Steroidal Anti-Inflammatory Agents><Null Mouse><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Outcome><Outcome Study><P2RY7><P2Y7><PPAR alpha><PPAR-α><PPARalpha><PPARα><Pain><Pain Control><Pain Therapy><Pain management><Painful><Pathway interactions><Pb element><Peripheral Nervous System><Peroxisome Proliferator-Activated Receptor alpha><Peroxisome Proliferator-Activated Receptor α><Population><Position><Positioning Attribute><Proteins><Purinergic Receptor P2Y, G Protein-Coupled, 7><Purinoceptor P2Y7><QOL><Quality of life><Reactive Site><Receptor Activation><Receptor Protein><Regulation><SIS cytokines><Schedule><Sensory Neurons><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Site><Spinal Ganglia><TLR4><TLR4 gene><TRP channel><TRPA channel><TRPA1 Channel><TRPV1><TRPV1 gene><Testing><Therapeutic><Tissues><Toll Homologue><Transient receptor potential channel><Transport Protein Gene><Transport Proteins><Transporter Protein><Vanilloid><Work><addiction><addiction liability><addiction potential><addictive disorder><adulthood><analgesia><anandamide><antinociception><antinociceptive><arachidonoyl ethanolamide><arachidonoylethanolamide><arachidonylethanolamide><arthritic pain><arthritis pain><biologic><biological signal transduction><biosynthesis><cannabinoid receptor><chemoattractant cytokine><chemokine><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><clinical test><cytokine><developmental><dorsal root ganglion><drug development><electrophysiological><extracellular><fatty acid-binding proteins><heavy metal Pb><heavy metal lead><hyperalgia><imaging><improved><in vivo><inflammatory modulation><inflammatory pain><inhibitor><lipid transport><mutant><neurochemical><neurochemistry><neuronal><neuropathic pain><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation><nociceptive><nociceptive neurons><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><non-steroidal anti-inflammatory drugs><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><opiate abuse><opiate consumption><opiate drug abuse><opiate drug use><opiate intake><opiate use><opioid abuse><opioid addiction><opioid consumption><opioid dependence><opioid dependent><opioid drug abuse><opioid drug use><opioid intake><opioid use><pain intervention><pain killer><pain medication><pain model><pain relief><pain reliever><pain treatment><pain-sensing neurons><pain-sensing sensory neurons><pain-sensing somatosensory neurons><painful neuropathy><painkiller><palmidrol><palmitoylethanolamide><palmitylethanolamide><pathway><pre-clinical><preclinical><protein function><receptor><relieve pain><research clinical testing><toll-like receptor 4><transient receptor potential ankyrin><transient receptor potential cation channel V1><transient receptor potential channel subfamily A><translational opportunities><translational potential><treat chronic pain>

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Ku-Lung Hsu

UNIVERSITY OF TEXAS AT AUSTIN, AUSTIN, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$503,536

FY 2026

Project Title

Endocannabinoid Biosynthesis in Inflammation and Pain

Grant Number:

5R01DA043571-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary In the initial 5 years of this grant, our group has advanced the field of endocannabinoid therapeutics by discovering novel metabolic and signaling functions for the endocannabinoid biosynthetic enzyme DAGLβ in inflammation and pain response. We developed drug delivery strategies for...

Research Terms

<2-AG><2-arachidonoyl-glycerol><2-arachidonoyl-sn-glycerol><2-arachidonoylglycerol><2-arachidonyl-glycerol><2-arachidonylglycerol><ATP-protein phosphotransferase><Address><Anabolism><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Anzatax><Asotax><Automobile Driving><Binding><Bioenergetics><Biologic Models><Biological><Biological Models><Biology><Body Tissues><Bristaxol><C(6)-ceramide><C6-ceramide><Cannabinoids><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Ceramides><Chemicals><Chemistry><Chemotherapy-induced peripheral neuropathy><Clinical><DAG lipase><Data><Development><Diacylglycerol Lipase><Diglyceride Lipase><Dimethylbiguanidine><Dimethylguanylguanidine><Drug Delivery><Drug Delivery Systems><Drugs><Economic Burden><Electrophysiology><Electrophysiology (science)><Endocannabinoids><Endogenous Cannabinoids><Enzyme Gene><Enzymes><Event><Formulation><Funding><Genetic><Goals><Grant><Heparin-Clearing Factor><Immune><Immunes><Inflammation><Inflammatory><Inflammatory Response><Infrastructure><Innate Immune Response><Intracellular Communication and Signaling><Investigation><Investments><Kinase Family Gene><Kinases><Knowledge><L-Serine><L-Threonine><LKB1><LKB1/STK11 Gene><Life><Lipemia-Clearing Factor><Lipids><Liposomal><Liposomes><Macrophage><Mediating><Medication><Membrane><Metabolic><Metformin><Mice><Mice Mammals><Model System><Modeling><Molecular><Molecular Interaction><Murine><Mus><Mφ><N,N-dimethyl-imidodicarbonimidic diamide><N-caproylsphingosine><N-hexanoylsphingosine><Neurophysiology / Electrophysiology><Nociception><Nociceptors><Opiate Addiction><Opiate Dependence><Paclitaxel><Paclitaxel (Taxol)><Pain><Pain Control><Pain Therapy><Pain management><Painful><Paper><Pathogenicity><Pathway interactions><Peripheral><Pharmaceutical Preparations><Pharmacologic Actions><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Post-Heparin Lipase><Postheparin Lipase><Postheparin Lipoprotein Lipase><Praxel><Pre-Clinical Model><Preclinical Models><Prevalence><Productivity><Protein Kinase><Protein Phosphorylation><Proteins><Publishing><Regulation><STK11><STK11 gene><Serine><Signal Transduction><Signal Transduction Systems><Signaling><Site><System><Taxol><Taxol A><Taxol Konzentrat><Technology><Testing><Therapeutic><Threonine><Tissues><Transphosphorylases><Triacylglycero-protein acylhydrolase><Work><antinociception><antinociceptive><behavioral pharmacology><biologic><biological signal transduction><biomarker discovery><biosynthesis><chemoproteomics><chronic pain><chronic pain patient><clearing factor lipase><developmental><driving><drug discovery><drug/agent><druggable target><efficacy testing><electrophysiological><fat metabolism><glycogen synthase a kinase><hydroxyalkyl protein kinase><improved><in vivo><inflammatory pain><inhibitor><insight><lipid metabolism><lipidomics><lipoprotein lipase><liposomal formulation><liposomal preparation><liver kinase B1><loss of function><membrane activity><membrane structure><nanoliposomal><nanoliposome><neuropathic pain><nociceptive><nociceptive neurons><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><opiate crisis><opioid addiction><opioid crisis><opioid dependence><opioid dependent><opioid epidemic><pain intervention><pain killer><pain medication><pain model><pain reduction><pain reliever><pain treatment><pain-sensing neurons><pain-sensing sensory neurons><pain-sensing somatosensory neurons><painful neuropathy><painkiller><pathway><patient with chronic pain><pharmacobehavioral><pharmacologic><phospho-proteomics><phosphoproteomics><phosphorylase b kinase kinase><pre-clinical><preclinical><programs><reduce pain><response><restraint><sensor><triacylglycerol protein acylhydrolase>

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Peter James Hamilton

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$502,202

FY 2026

Project Title

Reprogramming KZFP function to understand drug-specific transcription and behavior

Grant Number:

5R01DA058089-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY In this revised R01, we propose to use novel synthetic transcription factors (TFs) delivered to the mouse nucleus accumbens (NAc), a key brain reward region, to uncover and manipulate the cell-type-specific brain molecular processes that distinguish stimulant versus opioid addiction....

Research Terms

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Benjamin Patrick Brown

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$475,500

FY 2026

Project Title

Developing a computational platform for induced-fit and chemogenetic drug design

Grant Number:

5DP1DA058349-04

Activity Code:

DP1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Prescription opioid therapy plays a critical role in the clinical management of pain in multiple acute and chronic settings. The challenges of effective pain management have led to over 2 million adults in the US, and over 12 million globally, with an opioid use disorder (OUD). OUD a...

Research Terms

<21+ years old><Absence of pain sensation><Absence of sensibility to pain><Acute><Adopted><Adult><Adult Human><Agonist><Algorithms><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Back><Cell Communication and Signaling><Cell Signaling><Cessation of life><Chronic><Clinical><Clinical Management><Collaborations><Computer Assisted><DREADDs><Dangerousness><Death><Docking><Dorsum><Drug Design><Drugs><Feedback><Feels no pain><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Genetic><Intracellular Communication and Signaling><Ligands><Medication><Methods><Modeling><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><No sensitivity to pain><Opiate Addiction><Opiate Dependence><Opiate Receptors><Opioid Receptor><Pain Control><Pain Therapy><Pain management><Pharmaceutical Preparations><Play><Property><Proteins><Rapid screening><Receptor Protein><Research Resources><Resources><Respiratory Depression><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Structure><Therapeutic><Time><Ventilatory Depression><adulthood><analgesia><biological signal transduction><chemical library><computational platform><computer aided><computing platform><conformation><conformational><conformational state><conformationally><conformations><deep learning><deep learning method><deep learning strategy><depressed breathing><depression of breathing><design><designer receptors exclusively activated by designer drugs><designing><drug discovery><drug/agent><in silico><innovate><innovation><innovative><interest><lead optimization><licit opioid><mu opioid receptors><novel><opiate medication><opiate therapy><opiate use disorder><opioid addiction><opioid dependence><opioid dependent><opioid medication><opioid therapy><opioid use disorder><pain intervention><pain killer><pain medication><pain reliever><pain treatment><painkiller><plasma protein Z><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><protein Z><protein structure prediction><receptor><recruit><side effect><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic opioid><tool><μ opioid receptors><μ-OR><μOR>

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Katherine Mercedes Holleran

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Good lead · 66/100

Likely hiring

Solid budget

Recent

Active award

$465,000

FY 2026

Project Title

Alcohol/Stress Effects on Kappa Opioid Receptors in the Amygdala and Accumbens

Grant Number:

5U01AA014091-24

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2003

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY Stress is a well-known factor in promoting heavy drinking and relapse to drinking in individuals with alcohol use disorder (AUD), and avoidance of the negative affective symptoms of ethanol withdrawal (e.g. anxiety and depression) is also believed to play a critical role in relapse. Further,...

Research Terms

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SARA RAULERSON JONES

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Good lead · 66/100

Likely hiring

Solid budget

Recent

Active award

$465,000

FY 2026

Project Title

Alcohol/Stress Effects on Kappa Opioid Receptors in the Amygdala and Accumbens

Grant Number:

5U01AA014091-24

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2003

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY Stress is a well-known factor in promoting heavy drinking and relapse to drinking in individuals with alcohol use disorder (AUD), and avoidance of the negative affective symptoms of ethanol withdrawal (e.g. anxiety and depression) is also believed to play a critical role in relapse. Further,...

Research Terms

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Amynah Amir Ali Pradhan

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$463,474

FY 2026

Project Title

The role of delta opioid receptors in trigeminovascular pain

Grant Number:

5R01NS130882-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Chronic use of commonly used migraine therapies can lead to medication overuse headache (MOH). This is a paradoxical increase in severity of migraine-associated symptoms and headaches which are refractory to other treatments. Currently, the first-line treatment for MOH is drug cessation. However, du...

Research Terms

<3,5 cyclic AMP synthetase><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><Absence of pain sensation><Absence of sensibility to pain><Abstinence><Acute><Adenyl Cyclase><Adenylate Cyclase><Adenylyl Cyclase><Affect><Agonist><Aminalon><Aminalone><Analgesic Overuse Headaches><Assay><Auras><Behavioral><Binding><Bioassay><Biochemical><Biological Assay><Brain region><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cephalalgia><Cephalgia><Cephalgia Syndromes><Cephalic><Cephalodynia><Chronic><Clinical><Clinical Trials><Complex><Cranial><Cranial Pain><Data><Disease><Disorder><Drug Therapy><Drugs><Effectiveness><Electrophysiology><Electrophysiology (science)><Emotional><Feels no pain><Funding><G-Proteins><GABA><GTP-Binding Proteins><GTP-Regulatory Proteins><Gasser's Ganglion><Gasserian Ganglion><Genetic><Goals><Grant><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><Head Pain><Headache><Headache Disorders><Hot Spot><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><In Situ Hybridization><Individual><Intracellular Communication and Signaling><Knock-out><Knockout><Link><Maps><Medication><Mesencephalic Central Gray><Midbrain Central Gray><Migraine><Migraine Headache><Modeling><Molecular Interaction><Neurophysiology / Electrophysiology><No sensitivity to pain><Nucleus of the Fifth Nerve><Opiate Receptors><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid Receptor><Opioid agonist><Opioid receptor agonist><PAC1 receptor><PACAP><PACAP type I receptor><PACAPR-1 protein><Pain><Painful><Patients><Periaqueductal Gray><Peripheral><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Population><Post-Traumatic Headaches><Posttraumatic Headaches><Prevalence><QOL><Quality of life><Receptor Activation><Receptor Protein><Refractory><Role><Semilunar Ganglion><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Site><Source><Structure of trigeminal ganglion><System><Testing><Therapeutic><Trigeminal Ganglias><Trigeminal Ganglion><Trigeminal Nuclei><Trigeminal System><Viral><Work><abuse liability><abuse potential><allodynia><analgesia><annulus of the aqueduct><associated symptom><biological signal transduction><chronic pain><co-morbid symptom><co-occuring symptom><comorbid symptom><concurrent symptom><conditional knock-out><conditional knockout><cooccuring symptom><delta opioid receptor><determine efficacy><disability><drug development><drug intervention><drug treatment><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electrophysiological><evaluate efficacy><evidence base><examine efficacy><experiment><experimental research><experimental study><experiments><gamma-Aminobutyric Acid><head ache><in situ Hybridization Genetics><in situ Hybridization Staining Method><inhibitor><innovate><innovation><innovative><insight><interdisciplinary approach><medication overuse headache><midbrain central gray substance><migraine therapy><migraine treatment><multidisciplinary approach><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pain processing><pain sensitivity><periaqueductal gray matter><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pituitary adenylate cyclase activating peptide><pituitary adenylate cyclase activating polypeptide><pituitary adenylate cyclase-activating peptide receptor, type I><presynaptic><receptor><receptor expression><return to use><social role><symptom association><symptom comorbidity><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><translational model><trigeminal><triptans><γ-Aminobutyric Acid><δ OR><δ ORs><δ opioid receptors><δ-OR><δ-ORs><δOR><δORs>

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Tao Che

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$457,055

FY 2026

Project Title

Mechanisms and Regulations of kappa Opioid Receptor Signaling

Grant Number:

5R01DA058020-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Opiates have been widely prescribed for pain management in the US, with a staggering 142 million prescriptions in 2020 alone. While these drugs effectively relieve pain by interacting with the mu opioid receptor (MOR), their complex pharmacology has led to concerning side effects such as abuse poten...

Research Terms

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Mahmoud Salama Ahmed

TEXAS TECH UNIVERSITY HEALTH SCIS CENTER, LUBBOCK, TX

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$388,400

FY 2026

Project Title

Identification of novel lead EphB1/2 tyrosine kinase inhibitors targeting peripheral neuropathic pain

Grant Number:

5R01NS136485-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ ABSTRACT. Chronic pain is a common debilitating condition that often leads to the prescription of escalating opioid doses and has created a nationwide severe crisis. In September 2022, the American Medical Association issued a report entitled "Nation's opioid-related overdose and de...

Research Terms

<2-hydroxyphenylalanine><2-tyrosine><Acute><Address><American Medical Association><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Anxiety><Anzatax><Asotax><Behavior><Behavioral><Binding><Biological Markers><Brain><Brain Nervous System><Bristaxol><CNS Nervous System><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Cell Communication and Signaling><Cell Signaling><Central Nervous System><Cessation of life><Complex><Crystallization><Death><Development><Dorsal Horn Cells><Dorsal Horn Neurons><Dorsal Horn of the Spinal Cord><Dorsal Root Ganglia><Dose><Drug Kinetics><Drug Synthesis and Chemistry><EPH- and ELK-Related Tyrosine Kinase><EPH-and ELK-Related Kinase><Encephalon><Eph Receptor Ligands><Ephrin Type-A Receptor 8><Ephrin Type-A Receptor 8 Precursor><Ephrins><Epidemic><Event><FBJ Murine Osteosarcoma Viral Oncogene Homolog><FBJ osteosarcoma oncogene><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><FOS Family Protein><FOS Protein><FOS gene><Family member><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><G0S7><Gene Expression><Generations><Goals><Half-Life><Heterozygote><Immediate-Early Genes><Immunoblotting><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><In Vitro><Inflammation><Inflammatory><Injury><Intracellular Communication and Signaling><KO mice><Kinases><Knock-out Mice><Knockout Mice><Lead><Ligands><Maintenance><Measures><Mediating><Medulla Spinalis><Mice><Mice Mammals><Minocycline><Miscellaneous Antibiotic><Molecular><Molecular Interaction><Murine><Mus><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><NMDA Receptor-Ionophore Complex><NMDA Receptors><Nerve><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neuraxis><Neurobiology><Neurocyte><Neuronal Transmission><Neurons><Nociception><Null Mouse><Opiates><Opioid><PNS Diseases><PTK Inhibitors><PTK Receptors><Paclitaxel><Paclitaxel (Taxol)><Pain><Painful><Pathologic><Pathway interactions><Pb element><Perception><Peripheral><Peripheral Nerve Diseases><Peripheral Nervous System><Peripheral Nervous System Diseases><Peripheral Nervous System Disorders><Peripheral Neuropathy><Permeability><Pharmacokinetics><Phosphotransferase Gene><Phosphotransferases><Posterior Horn Cells><Posterior Horn Neurons><Praxel><Protein Tyrosine Kinase><Protein Tyrosine Kinase EEK><Protein Tyrosine Kinase Inhibitors><Protooncogene FOS><Receptor Protein><Receptor Protein-Tyrosine Kinases><Receptor Tyrosine Kinase Gene><Reporting><Rodent Model><Role><Signal Transduction><Signal Transduction Systems><Signaling><Spinal Cord><Spinal Ganglia><Spinal cord posterior horn><Stimulus><Structure><Synapses><Synaptic><TK Inhibitors><Taxol><Taxol A><Taxol Konzentrat><Tetracyclines><Thermal Hyperalgesias><Transmembrane Receptor Protein Tyrosine Kinase><Transphosphorylases><Tyrosine Kinase><Tyrosine Kinase Inhibitor><Tyrosine Kinase Linked Receptors><Tyrosine Kinase Receptors><Tyrosine-Protein Kinase Receptor EEK><Tyrosine-Specific Protein Kinase><Tyrosylprotein Kinase><United States><Western Blotting><Western Immunoblotting><allodynia><analog><axon signaling><axon-glial signaling><axonal signaling><behavior study><behavioral study><bio-markers><biologic marker><biological signal transduction><biomarker><c fos><c-fos Gene><c-fos Protein><c-fos Proto-Oncogenes><central sensitization><chronic constriction injury><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><constriction><developmental><dorsal root ganglion><drug synthesis><experiment><experimental research><experimental study><experiments><glia signaling><glial signaling><heavy metal Pb><heavy metal lead><heterozygosity><hydroxyaryl protein kinase><in vivo><inflammatory pain><inhibitor><injuries><kinase inhibitor><licit opioid><mechanical allodynia><multidisciplinary><nerve damage><nerve signaling><neural signaling><neurobiological><neuronal><neuronal signaling><neuropathic pain><neurotransmission><next generation><nociceptive><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><opiate medication><opiate overdose><opiate related overdose><opioid drug overdose><opioid induced overdose><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><ortho-tyrosine><pain behavior><pain model><pain processing><painful neuropathy><pathway><pharmacologic><pre-clinical><preclinical><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><protein blotting><receptor><scaffold><scaffolding><sciatic nerve><sciatic nerve injury><social role><synapse><synergism><tool><treat chronic pain><tyrosyl protein kinase><v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog><validation studies>

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Shahani Noor

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$357,305

FY 2026

Project Title

Prenatal alcohol exposure generates vulnerability to the proinflammatory effects of morphine and adverse neuroimmune consequences

Grant Number:

5R01AA029694-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Exposure to alcohol during gestation can lead to a constellation of mild to severe cognitive and behavioral deficits referred to as Fetal Alcohol Spectrum Disorders (FASD), having a US prevalence as high as ~4.8%. Although clinical studies on long-term consequences of prenatal alcoho...

Research Terms

<(TNF)-α><21+ years old><Acute><Adult><Adult Human><Alcohol Chemical Class><Alcohol abuse><Alcohols><Animal Model><Animal Models and Related Studies><Astrocytes><Astrocytus><Astroglia><Behavioral><Beta Proprotein Interleukin 1><Biological><CNS Nervous System><Cachectin><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Chronic><Clinical><Clinical Research><Clinical Study><Cognitive><Common Rat Strains><Curiosities><Data><Diathesis><Disease susceptibility><Dose><Down-Regulation><Dysfunction><Endogenous Factors><EtOH abuse><Etiology><Evaluation><FASD><Family><Fetal Alcohol Exposure><Fetal Alcohol Spectrum Disorder><Fetal ETOH Exposure><Fetal Ethanol Exposure><Fetal alcohol effects><Functional RNA><Functional disorder><Future><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gestation><Glia><Glial Cells><Goals><High Prevalence><History><Hyperalgesia><Hyperalgesic Sensations><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunes><Immunologic Diseases><Immunologic Receptors><Immunological Diseases><Immunological Dysfunction><Immunological Receptors><Immunological System Dysfunction><In Utero Alcohol Exposure><In Utero ETOH Exposure><In Utero Ethanol Exposure><Individual><Infiltration><Inflammasome><Inflammatory><Infumorph><Injury><Interleukin 1beta><Interleukin-1 beta><Interleukin-1β><Intracellular Communication and Signaling><Investigation><Kadian><Kolliker's reticulum><Life><Light><MEFV gene product><MS Contin><MSir><Macrophage><Macrophage Activation><Macrophage-Derived TNF><Mediating><Messenger RNA><Mice><Mice Mammals><Modeling><Monocyte-Derived TNF><Morphia><Morphine><Murine><Mus><Mφ><Naloxone><Narcan><Narcanti><Nerve><Neuraxis><Neuroglia><Neuroglial Cells><Neuroimmune><Neurologic Dysfunctions><Non-neuronal cell><Noncoding RNA><Nonneuronal cell><Nontranslated RNA><Opiates><Opioid><Oramorph><Oramorph SR><Outcome><Pain><Pain Control><Pain Therapy><Pain management><Painful><Pathologic><Pathology><Pathway interactions><Peripheral><Photoradiation><Physiological Adaptation><Physiopathology><Population><Predisposition><Pregnancy><Preinterleukin 1 Beta><Prenatal Alcohol Exposure><Prenatal ETOH Exposure><Prenatal Ethanol Exposure><Prevalence><Process><Production><Proteins><Public Health><Rat><Rats Mammals><Rattus><Receptor Activation><Receptor Protein><Receptor Signaling><Recording of previous events><Risk><Risk Factors><Role><Roxanol><Signal Transduction><Signal Transduction Systems><Signaling><Spinal><Statex SR><Substance Use Disorder><Substance abuse problem><Susceptibility><TLR protein><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Therapeutic><Toll-Like Receptor Family Gene><Toll-like receptors><Touch><Touch sensation><Transcript Expression Analyses><Transcript Expression Analysis><Transcription Initiation><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Untranslated RNA><Work><abuse of substances><adulthood><alcohol co-abuse><alcohol exposed><alcohol exposure><alcohol problem><alcohol-exposed pregnancy><allodynia><analyze gene expression><antagonism><antagonist><astrocytic glia><biologic><biological signal transduction><causation><cell type><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><circular RNA><closed circular RNA><cytokine><disease causation><enhancing factor><ethanol abuse><ethanol exposed><ethanol exposure><exposed to alcohol><exposed to alcohol prenatally><exposed to ethanol><exposure to alcohol><exposure to ethanol><gene expression analysis><gene expression assay><gestation ETOH exposure><gestation alcohol exposure><gestation ethanol exposure><gestational ethanol exposure><hazardous alcohol use><histories><hyperalgia><immune receptor><in vivo><injuries><liability to disease><mRNA><marenostrin><model of animal><mouse model><mu opioid receptors><murine model><nerve cement><nerve injury><neural injury><neurobehavioral><neurological dysfunction><non-medical opioid use><noncoding><nonmedical opioid use><novel><offspring><opiate exposure><opiate misuse><opioid exposure><opioid misuse><overexpress><overexpression><pain intervention><pain treatment><pathophysiology><pathway><pre-clinical><preclinical><pregnancy ETOH exposure><pregnancy alcohol exposure><pregnancy ethanol exposure><prenatal alcohol effect><prenatally alcohol exposed><prenatally exposed to alcohol><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><pyrin><receptor><response><risk mitigation><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem><substance abuse><substance use><substance use and disorder><substance using><tactile sensation><transcriptional profiling><treat chronic pain><μ opioid receptors><μ-OR><μOR>

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Ream Al-Hasani

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$353,249

FY 2026

Project Title

Peripheral Mechanisms of Kappa Opioid Receptor-Mediated Cold Hypersensitivity

Grant Number:

5R01NS123070-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The overall goal of this research is to better understand the how the kappa opioid receptor (KOR) system modulates cold hypersensitivity with the ultimate goal of uncovering a novel therapeutic target. Cold pain affects a number of diverse groups of patients and goes largely untreate...

Research Terms

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NAZIRA EL-HAGE

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$349,157

FY 2026

Project Title

Function of astrocytes autophagy in brain homeostasis and opioid-induced maladaptive behavior and addiction, in the context of HIV

Grant Number:

5R01DA057884-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY/ABSTRACT The overarching goal of this proposal is to identify and characterize mechanistic pathways in astrocytes responsible for changes in drug-evoked structural and synaptic plasticity that underlie the maladaptive behavior in opioid drug abuse. Astrocytes are a logical focus for these st...

Research Terms

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Jay P. McLaughlin

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$349,157

FY 2026

Project Title

Function of astrocytes autophagy in brain homeostasis and opioid-induced maladaptive behavior and addiction, in the context of HIV

Grant Number:

5R01DA057884-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY/ABSTRACT The overarching goal of this proposal is to identify and characterize mechanistic pathways in astrocytes responsible for changes in drug-evoked structural and synaptic plasticity that underlie the maladaptive behavior in opioid drug abuse. Astrocytes are a logical focus for these st...

Research Terms

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RU-RONG JI

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, LA JOLLA, CA

Good lead · 62/100

Large award

Very recent

Active award

Team-scale grant

$3,855,681

FY 2026

Project Title

Neurotensin 1 allosteric modulator for the treatment of pain

Grant Number:

1UG3NS141745-01A1

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The NIH HEAL Initiative aims to tackle two ongoing health care crises: opioid use disorder and uncontrolled pain. Pharmacological approaches targeting both crises are urgently needed. The neurotensin receptor 1 (NTR1) has been a sought-after target for the treatment of both pain and ...

Research Terms

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Steven H Olson

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, LA JOLLA, CA

Good lead · 62/100

Large award

Very recent

Active award

Team-scale grant

$3,855,681

FY 2026

Project Title

Neurotensin 1 allosteric modulator for the treatment of pain

Grant Number:

1UG3NS141745-01A1

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The NIH HEAL Initiative aims to tackle two ongoing health care crises: opioid use disorder and uncontrolled pain. Pharmacological approaches targeting both crises are urgently needed. The neurotensin receptor 1 (NTR1) has been a sought-after target for the treatment of both pain and ...

Research Terms

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Lauren M Slosky

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, LA JOLLA, CA

Good lead · 62/100

Large award

Very recent

Active award

Team-scale grant

$3,855,681

FY 2026

Project Title

Neurotensin 1 allosteric modulator for the treatment of pain

Grant Number:

1UG3NS141745-01A1

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The NIH HEAL Initiative aims to tackle two ongoing health care crises: opioid use disorder and uncontrolled pain. Pharmacological approaches targeting both crises are urgently needed. The neurotensin receptor 1 (NTR1) has been a sought-after target for the treatment of both pain and ...

Research Terms

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SANDRA D. COMER

NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NEW YORK, NY

Good lead · 62/100

Large award

Very recent

Active award

Team-scale grant

$3,705,613

FY 2026

Project Title

Phase 1a/1b Clinical Trials of Multivalent Opioid Vaccine Components

Grant Number:

5UH3DA047711-04

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2018

End Date:

3/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Currently, abuse of prescription opioid analgesics and heroin is a pervasive problem in the U.S. Although several medications, including methadone, buprenorphine, and naltrexone, are available and effective in treating opioid use disorder (OUD), long-term relapse rates remain high. T...

Research Terms

<7S Gamma Globulin><Actiq><Active Follow-up><Adanon><Admission><Admission activity><Adsorption><Affinity><Althose><Alum Adjuvant><Antibodies><Antibody Response><Attenuated><B-Cells><B-Lymphocytes><B-cell><Behavior-Related Disorder><Behavior-Related Problem><Biological Agent><Biological Products><Blood><Blood Reticuloendothelial System><Blood Serum><Booster Immunization><Buprenorphine><Cell Communication and Signaling><Cell Signaling><Chemistry><Clinical Evaluation><Clinical Research><Clinical Study><Clinical Testing><Conjugate Vaccines><Data Analyses><Data Analysis><Development><Diacetylmorphine><Diagnosis><Diagnostic Findings><Diamorphine><Dihydrohydroxycodeinone><Dolophine><Dose><Drugs><Duragesic><Enrollment><Evaluation><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fentanest><Fentanyl><Fentyl><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Funding><Goals><Grant><Heroin><IND Filing><IND application><IND package><IND submission><IgG><Immune Monitoring><Immune response><Immunize><Immunoglobulin G><Immunologic Monitoring><Immunologic Tests><Immunological Monitoring><Immunological Tests><Immunomonitoring><Incidence><Individual><Infumorph><Inpatients><Intracellular Communication and Signaling><Investigational New Drug Application><KLH><KLH antigen><Kadian><Keyhole Limpet Hemocyanin><Laboratories><Lifestyle-Related Disorder><Lifestyle-Related Problem><Lifestyle-related condition><MS Contin><MSir><Maintenance><Measures><Medical Inspection><Medication><Methadone><Methadose><Morbidity - disease rate><Morphia><Morphine><Nalorex><Naltrexone><Nemexin><Opiates><Opioid><Opioid Analgesics><Oral><Oramorph><Oramorph SR><Out-patients><Outcome><Outpatients><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Participant><Patient Self-Report><Pattern><Pharmaceutical Preparations><Phase><Phase 1a/1b Clinical trial><Phase Ia/Ib Clinical Trial><Phentanyl><Physical Examination><Placebos><Pre IND FDA meeting><Pre-IND mtg><Public Health><ReVia><Recommendation><Relapse><Reporting><Research><Research Design><Rodent><Rodentia><Rodents Mammals><Roxanol><Roxicodone><Safety><Secondary Immunization><Self-Report><Serious Adverse Event><Serum><Severe Adverse Event><Sham Treatment><Signal Transduction><Signal Transduction Systems><Signaling><Signs and Symptoms><Site><Specificity><Statex SR><Study Type><Testing><Toxicology><Urine><Vaccination><Vaccines><Vivitrol><Withdrawal Symptom><abuse liability><abuse potential><active followup><alum><aluminum sulfate><attenuate><attenuates><biological signal transduction><biologics><biopharmaceutical><biotherapeutic agent><booster vaccination><clinical test><data interpretation><design><designing><determine efficacy><developmental><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><eligible participant><enroll><evaluate efficacy><examine efficacy><follow up><follow-up><followed up><followup><host response><immune system response><immunogenicity><immunoresponse><improved><keyhole-limpet hemacyanin><manufacture><morbidity rate><mortality><new approaches><novel><novel approaches><novel strategies><novel strategy><opiate analgesia><opiate analgesic><opiate consumption><opiate drug use><opiate intake><opiate pain medication><opiate pain reliever><opiate use><opiate use disorder><opiate withdrawal><opioid analgesia><opioid anesthetic><opioid consumption><opioid detox><opioid detoxification><opioid drug use><opioid intake><opioid medication abuse><opioid pain medication><opioid pain reliever><opioid painkiller><opioid prescription drug abuse><opioid use><opioid use disorder><opioid withdrawal><physical examinations><pre-IND consultation><pre-IND discussion><pre-IND meeting><pre-Investigational New Drug meeting><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prescription opiate abuse><prescription opioid abuse><primary end point><primary endpoint><research clinical testing><response><safety testing><screening><screenings><serious adverse experience><serious adverse reaction><sham therapy><side effect><study design><therapeutic vaccine><treatment strategy><treatment vaccines><vaccine efficacy><vaccine for the treatment><vaccine for treatment>

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Marco Pravetoni

NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NEW YORK, NY

Good lead · 62/100

Large award

Very recent

Active award

Team-scale grant

$3,705,613

FY 2026

Project Title

Phase 1a/1b Clinical Trials of Multivalent Opioid Vaccine Components

Grant Number:

5UH3DA047711-04

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2018

End Date:

3/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Currently, abuse of prescription opioid analgesics and heroin is a pervasive problem in the U.S. Although several medications, including methadone, buprenorphine, and naltrexone, are available and effective in treating opioid use disorder (OUD), long-term relapse rates remain high. T...

Research Terms

<7S Gamma Globulin><Actiq><Active Follow-up><Adanon><Admission><Admission activity><Adsorption><Affinity><Althose><Alum Adjuvant><Antibodies><Antibody Response><Attenuated><B-Cells><B-Lymphocytes><B-cell><Behavior-Related Disorder><Behavior-Related Problem><Biological Agent><Biological Products><Blood><Blood Reticuloendothelial System><Blood Serum><Booster Immunization><Buprenorphine><Cell Communication and Signaling><Cell Signaling><Chemistry><Clinical Evaluation><Clinical Research><Clinical Study><Clinical Testing><Conjugate Vaccines><Data Analyses><Data Analysis><Development><Diacetylmorphine><Diagnosis><Diagnostic Findings><Diamorphine><Dihydrohydroxycodeinone><Dolophine><Dose><Drugs><Duragesic><Enrollment><Evaluation><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fentanest><Fentanyl><Fentyl><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Funding><Goals><Grant><Heroin><IND Filing><IND application><IND package><IND submission><IgG><Immune Monitoring><Immune response><Immunize><Immunoglobulin G><Immunologic Monitoring><Immunologic Tests><Immunological Monitoring><Immunological Tests><Immunomonitoring><Incidence><Individual><Infumorph><Inpatients><Intracellular Communication and Signaling><Investigational New Drug Application><KLH><KLH antigen><Kadian><Keyhole Limpet Hemocyanin><Laboratories><Lifestyle-Related Disorder><Lifestyle-Related Problem><Lifestyle-related condition><MS Contin><MSir><Maintenance><Measures><Medical Inspection><Medication><Methadone><Methadose><Morbidity - disease rate><Morphia><Morphine><Nalorex><Naltrexone><Nemexin><Opiates><Opioid><Opioid Analgesics><Oral><Oramorph><Oramorph SR><Out-patients><Outcome><Outpatients><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Participant><Patient Self-Report><Pattern><Pharmaceutical Preparations><Phase><Phase 1a/1b Clinical trial><Phase Ia/Ib Clinical Trial><Phentanyl><Physical Examination><Placebos><Pre IND FDA meeting><Pre-IND mtg><Public Health><ReVia><Recommendation><Relapse><Reporting><Research><Research Design><Rodent><Rodentia><Rodents Mammals><Roxanol><Roxicodone><Safety><Secondary Immunization><Self-Report><Serious Adverse Event><Serum><Severe Adverse Event><Sham Treatment><Signal Transduction><Signal Transduction Systems><Signaling><Signs and Symptoms><Site><Specificity><Statex SR><Study Type><Testing><Toxicology><Urine><Vaccination><Vaccines><Vivitrol><Withdrawal Symptom><abuse liability><abuse potential><active followup><alum><aluminum sulfate><attenuate><attenuates><biological signal transduction><biologics><biopharmaceutical><biotherapeutic agent><booster vaccination><clinical test><data interpretation><design><designing><determine efficacy><developmental><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><eligible participant><enroll><evaluate efficacy><examine efficacy><follow up><follow-up><followed up><followup><host response><immune system response><immunogenicity><immunoresponse><improved><keyhole-limpet hemacyanin><manufacture><morbidity rate><mortality><new approaches><novel><novel approaches><novel strategies><novel strategy><opiate analgesia><opiate analgesic><opiate consumption><opiate drug use><opiate intake><opiate pain medication><opiate pain reliever><opiate use><opiate use disorder><opiate withdrawal><opioid analgesia><opioid anesthetic><opioid consumption><opioid detox><opioid detoxification><opioid drug use><opioid intake><opioid medication abuse><opioid pain medication><opioid pain reliever><opioid painkiller><opioid prescription drug abuse><opioid use><opioid use disorder><opioid withdrawal><physical examinations><pre-IND consultation><pre-IND discussion><pre-IND meeting><pre-Investigational New Drug meeting><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prescription opiate abuse><prescription opioid abuse><primary end point><primary endpoint><research clinical testing><response><safety testing><screening><screenings><serious adverse experience><serious adverse reaction><sham therapy><side effect><study design><therapeutic vaccine><treatment strategy><treatment vaccines><vaccine efficacy><vaccine for the treatment><vaccine for treatment>

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ANDREA C Enzinger

DANA-FARBER CANCER INST, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$715,755

FY 2026

Project Title

Variability in Opioid Prescribing Across the Cancer Care Continuum: A Multi-Level Analysis

Grant Number:

5R01CA279414-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/21/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The goal of this proposal is to develop a comprehensive understanding of the scope and key drivers of variations in the quality of opioid management across the cancer care trajectory, and to use this understanding to design a multi-level intervention to improve cancer pain management...

Research Terms

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Alexi A Wright

DANA-FARBER CANCER INST, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$715,755

FY 2026

Project Title

Variability in Opioid Prescribing Across the Cancer Care Continuum: A Multi-Level Analysis

Grant Number:

5R01CA279414-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/21/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The goal of this proposal is to develop a comprehensive understanding of the scope and key drivers of variations in the quality of opioid management across the cancer care trajectory, and to use this understanding to design a multi-level intervention to improve cancer pain management...

Research Terms

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Sandra Sanchez Roige

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$715,572

FY 2026

Project Title

Multivariate genome-wide association analysis of opioid-related traits in half a million diverse individuals

Grant Number:

5R01DA061977-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2025

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT We are in the middle of a global opioid epidemic. In 2020, 9.3 million Americans misused prescription opioid pain medications, with 8-12% going on to develop an opioid use disorder (OUD). OUD is highly heritable, but few of the relevant genes are known . A better understand...

Research Terms

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Shanna Babalonis

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$677,778

FY 2026

Project Title

Cannabis Modulation of Outcomes Related to Opioid Use Disorder: Opioid Withdrawal, Opioid Abuse Potential and Opioid Safety

Grant Number:

5R01DA054347-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract Opioids and cannabinoids are the two most widely used and misused drug classes. Worldwide, an estimated 53 million people misuse opioids. In the US, 2.6 million individuals meet criteria for opioid use disorder and nearly 47,000 people died in 2019 due to opioid overdose. At the same time,...

Research Terms

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Rajesh Khanna

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$597,047

FY 2026

Project Title

Dissection of NTSR2/calcium channel signaling as a non-opioid spinal analgesic mechanism for the treatment of high impact chronic pain

Grant Number:

5R01NS139492-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary: Spinal administration of analgesics such as opioids and local anesthetics via an implanted intrathecal drug delivery system have profound efficacy in some of the most severe high impact chronic pain conditions. Despite their profound efficacy, their use is limited primarily because ...

Research Terms

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Amol M Patwardhan

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$597,047

FY 2026

Project Title

Dissection of NTSR2/calcium channel signaling as a non-opioid spinal analgesic mechanism for the treatment of high impact chronic pain

Grant Number:

5R01NS139492-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary: Spinal administration of analgesics such as opioids and local anesthetics via an implanted intrathecal drug delivery system have profound efficacy in some of the most severe high impact chronic pain conditions. Despite their profound efficacy, their use is limited primarily because ...

Research Terms

View Full Project Details on NIH Reporter

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Lakshmi A Devi

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$588,331

FY 2026

Project Title

Regulation Of Opioid Receptor Signaling by Endogenous Peptides

Grant Number:

5R01DA008863-31

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/1995

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The current opioid epidemic highlights the need for a deeper understanding of how opioid receptors are activated in our body. Our knowledge about the downstream events following opioid receptor activation comes mainly from studies on opiates (e.g., morphine), synthetic drugs (e.g., fentanyl), and mo...

Research Terms

<ACTH-beta-Lipotropin Precursor><Actiq><Acute><Address><Affinity><Agonist><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Assay><Binding><Bioassay><Biological><Biological Assay><Brain><Brain Nervous System><Brain region><Breast Cell Glutaminase><Cell Body><Cell Communication and Signaling><Cell Line><Cell Nucleus><Cell Signaling><Cell surface><CellLine><Cells><Cessation of life><Collaborations><Corticotropin-beta-Lipotropin Precursor><Dangerousness><Data><Data Analyses><Data Analysis><Death><Disease><Disorder><Drugs><Duragesic><Dynorphins><EC 3.5.1.2><Electrophysiology><Electrophysiology (science)><Encephalon><Endorphin-ACTH Precursor><Endorphins><Endosomes><Enkephalins><Event><Exhibits><Fentanest><Fentanyl><Fentyl><Fluorescence Light Microscopy><Fluorescence Microscopy><Foundations><G-Proteins><GA Protein><GTP-Binding Proteins><GTP-Regulatory Proteins><Glutaminase><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><In Situ><In Vitro><Individual><Infumorph><Intracellular Communication and Signaling><Kadian><Kinases><Knowledge><L glutamine amidohydrolase><Ligands><Liver Glutaminase><Location><MAP kinase><MS Contin><MSir><Mediating><Mediator><Medication><Medicine><Mental Depression><Mitogen-Activated Protein Kinases><Modeling><Modernization><Molecular Interaction><Monitor><Morphia><Morphine><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nucleus><Opiate Peptides><Opiate Receptors><Opiates><Opioid><Opioid Peptide><Opioid Receptor><Oramorph><Oramorph SR><Organelles><Organism-Level Process><Organismal Process><Pain Control><Pain Therapy><Pain management><Pathway interactions><Pattern><Peptide Receptor><Peptides><Pharmaceutical Preparations><Phentanyl><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiologic Processes><Physiological><Physiological Processes><Play><Pro-ACTH-Endorphin><Pro-Opio-Melanocortin><Pro-Opiocortin><Pro-Opiomelanocortin><Proopiocortin><Proopiomelanocortin><Property><Receptor Activation><Receptor Protein><Receptor Signaling><Receptosomes><Recycling><Regulation><Reporting><Respiration><Respiratory Depression><Rewards><Role><Roxanol><Scientist><Sight><Signal Induction><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Slice><Statex SR><Strains Cell Lines><Substance Use Disorder><System><Talents><Techniques><Testing><Time><Toxic effect><Toxicities><Translating><Transphosphorylases><VHH><VHH antibody><Ventilatory Depression><Ventral Tegmental Area><Vision><Work><addiction><addiction liability><addiction potential><addictive disorder><antinociception><antinociceptive><arrestin B><beta-arrestin><biologic><biological signal transduction><brain tissue><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><clinical relevance><clinically relevant><cultured cell line><data interpretation><data mining><datamining><delta opioid receptor><depressed breathing><depression><depression of breathing><desensitization><design><designing><drug development><drug/agent><electrophysiological><endogenous opiate><endogenous opioids><experiment><experimental research><experimental study><experiments><in vivo><large data sets><large datasets><mu opioid receptors><nano-molar><nanobodies><nanobody><nanomolar><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><opiate crisis><opiate use disorder><opioid associated apnea><opioid associated respiratory depression><opioid crisis><opioid epidemic><opioid induced hypoventilation><opioid induced respiratory depression><opioid mediated respiratory depression><opioid related respiratory depression><opioid respiratory depression><opioid use disorder><opioid ventilatory depression><pain intervention><pain killer><pain medication><pain reliever><pain treatment><painkiller><pathway><pro-enkephalin><prodynorphin><proenkephalin><protein kinase C kinase><receptor><receptor function><respiratory depression caused by opioids><respiratory depression due to opioids><respiratory mechanism><response><sdAb><secondary analysis><side effect><single domain antibodies><social role><substance use and disorder><synthetic drug><synthetic opiate><synthetic opioid><therapeutic agent development><therapeutic development><therapeutic target><trafficking><variable heavy chain antibody><ventral tegmentum><visual function><β-arrestin><δ OR><δ ORs><δ opioid receptors><δ-OR><δ-ORs><δOR><δORs><μ opioid receptors><μ-OR><μOR>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Elyssa Margolis

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$588,331

FY 2026

Project Title

Regulation Of Opioid Receptor Signaling by Endogenous Peptides

Grant Number:

5R01DA008863-31

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/1995

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The current opioid epidemic highlights the need for a deeper understanding of how opioid receptors are activated in our body. Our knowledge about the downstream events following opioid receptor activation comes mainly from studies on opiates (e.g., morphine), synthetic drugs (e.g., fentanyl), and mo...

Research Terms

<ACTH-beta-Lipotropin Precursor><Actiq><Acute><Address><Affinity><Agonist><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Assay><Binding><Bioassay><Biological><Biological Assay><Brain><Brain Nervous System><Brain region><Breast Cell Glutaminase><Cell Body><Cell Communication and Signaling><Cell Line><Cell Nucleus><Cell Signaling><Cell surface><CellLine><Cells><Cessation of life><Collaborations><Corticotropin-beta-Lipotropin Precursor><Dangerousness><Data><Data Analyses><Data Analysis><Death><Disease><Disorder><Drugs><Duragesic><Dynorphins><EC 3.5.1.2><Electrophysiology><Electrophysiology (science)><Encephalon><Endorphin-ACTH Precursor><Endorphins><Endosomes><Enkephalins><Event><Exhibits><Fentanest><Fentanyl><Fentyl><Fluorescence Light Microscopy><Fluorescence Microscopy><Foundations><G-Proteins><GA Protein><GTP-Binding Proteins><GTP-Regulatory Proteins><Glutaminase><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><In Situ><In Vitro><Individual><Infumorph><Intracellular Communication and Signaling><Kadian><Kinases><Knowledge><L glutamine amidohydrolase><Ligands><Liver Glutaminase><Location><MAP kinase><MS Contin><MSir><Mediating><Mediator><Medication><Medicine><Mental Depression><Mitogen-Activated Protein Kinases><Modeling><Modernization><Molecular Interaction><Monitor><Morphia><Morphine><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nucleus><Opiate Peptides><Opiate Receptors><Opiates><Opioid><Opioid Peptide><Opioid Receptor><Oramorph><Oramorph SR><Organelles><Organism-Level Process><Organismal Process><Pain Control><Pain Therapy><Pain management><Pathway interactions><Pattern><Peptide Receptor><Peptides><Pharmaceutical Preparations><Phentanyl><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiologic Processes><Physiological><Physiological Processes><Play><Pro-ACTH-Endorphin><Pro-Opio-Melanocortin><Pro-Opiocortin><Pro-Opiomelanocortin><Proopiocortin><Proopiomelanocortin><Property><Receptor Activation><Receptor Protein><Receptor Signaling><Receptosomes><Recycling><Regulation><Reporting><Respiration><Respiratory Depression><Rewards><Role><Roxanol><Scientist><Sight><Signal Induction><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Slice><Statex SR><Strains Cell Lines><Substance Use Disorder><System><Talents><Techniques><Testing><Time><Toxic effect><Toxicities><Translating><Transphosphorylases><VHH><VHH antibody><Ventilatory Depression><Ventral Tegmental Area><Vision><Work><addiction><addiction liability><addiction potential><addictive disorder><antinociception><antinociceptive><arrestin B><beta-arrestin><biologic><biological signal transduction><brain tissue><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><clinical relevance><clinically relevant><cultured cell line><data interpretation><data mining><datamining><delta opioid receptor><depressed breathing><depression><depression of breathing><desensitization><design><designing><drug development><drug/agent><electrophysiological><endogenous opiate><endogenous opioids><experiment><experimental research><experimental study><experiments><in vivo><large data sets><large datasets><mu opioid receptors><nano-molar><nanobodies><nanobody><nanomolar><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><opiate crisis><opiate use disorder><opioid associated apnea><opioid associated respiratory depression><opioid crisis><opioid epidemic><opioid induced hypoventilation><opioid induced respiratory depression><opioid mediated respiratory depression><opioid related respiratory depression><opioid respiratory depression><opioid use disorder><opioid ventilatory depression><pain intervention><pain killer><pain medication><pain reliever><pain treatment><painkiller><pathway><pro-enkephalin><prodynorphin><proenkephalin><protein kinase C kinase><receptor><receptor function><respiratory depression caused by opioids><respiratory depression due to opioids><respiratory mechanism><response><sdAb><secondary analysis><side effect><single domain antibodies><social role><substance use and disorder><synthetic drug><synthetic opiate><synthetic opioid><therapeutic agent development><therapeutic development><therapeutic target><trafficking><variable heavy chain antibody><ventral tegmentum><visual function><β-arrestin><δ OR><δ ORs><δ opioid receptors><δ-OR><δ-ORs><δOR><δORs><μ opioid receptors><μ-OR><μOR>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Manojkumar A Puthenveedu

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$588,331

FY 2026

Project Title

Regulation Of Opioid Receptor Signaling by Endogenous Peptides

Grant Number:

5R01DA008863-31

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/1995

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The current opioid epidemic highlights the need for a deeper understanding of how opioid receptors are activated in our body. Our knowledge about the downstream events following opioid receptor activation comes mainly from studies on opiates (e.g., morphine), synthetic drugs (e.g., fentanyl), and mo...

Research Terms

<ACTH-beta-Lipotropin Precursor><Actiq><Acute><Address><Affinity><Agonist><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Assay><Binding><Bioassay><Biological><Biological Assay><Brain><Brain Nervous System><Brain region><Breast Cell Glutaminase><Cell Body><Cell Communication and Signaling><Cell Line><Cell Nucleus><Cell Signaling><Cell surface><CellLine><Cells><Cessation of life><Collaborations><Corticotropin-beta-Lipotropin Precursor><Dangerousness><Data><Data Analyses><Data Analysis><Death><Disease><Disorder><Drugs><Duragesic><Dynorphins><EC 3.5.1.2><Electrophysiology><Electrophysiology (science)><Encephalon><Endorphin-ACTH Precursor><Endorphins><Endosomes><Enkephalins><Event><Exhibits><Fentanest><Fentanyl><Fentyl><Fluorescence Light Microscopy><Fluorescence Microscopy><Foundations><G-Proteins><GA Protein><GTP-Binding Proteins><GTP-Regulatory Proteins><Glutaminase><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><In Situ><In Vitro><Individual><Infumorph><Intracellular Communication and Signaling><Kadian><Kinases><Knowledge><L glutamine amidohydrolase><Ligands><Liver Glutaminase><Location><MAP kinase><MS Contin><MSir><Mediating><Mediator><Medication><Medicine><Mental Depression><Mitogen-Activated Protein Kinases><Modeling><Modernization><Molecular Interaction><Monitor><Morphia><Morphine><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nucleus><Opiate Peptides><Opiate Receptors><Opiates><Opioid><Opioid Peptide><Opioid Receptor><Oramorph><Oramorph SR><Organelles><Organism-Level Process><Organismal Process><Pain Control><Pain Therapy><Pain management><Pathway interactions><Pattern><Peptide Receptor><Peptides><Pharmaceutical Preparations><Phentanyl><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiologic Processes><Physiological><Physiological Processes><Play><Pro-ACTH-Endorphin><Pro-Opio-Melanocortin><Pro-Opiocortin><Pro-Opiomelanocortin><Proopiocortin><Proopiomelanocortin><Property><Receptor Activation><Receptor Protein><Receptor Signaling><Receptosomes><Recycling><Regulation><Reporting><Respiration><Respiratory Depression><Rewards><Role><Roxanol><Scientist><Sight><Signal Induction><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Slice><Statex SR><Strains Cell Lines><Substance Use Disorder><System><Talents><Techniques><Testing><Time><Toxic effect><Toxicities><Translating><Transphosphorylases><VHH><VHH antibody><Ventilatory Depression><Ventral Tegmental Area><Vision><Work><addiction><addiction liability><addiction potential><addictive disorder><antinociception><antinociceptive><arrestin B><beta-arrestin><biologic><biological signal transduction><brain tissue><camelid antibody><camelid based antibody><camelid derived antibody><camelid derived fragment><camelid heavy chain only Abs><camelid immunoglobulin><camelid single chain antibody><camelid variable heavy chain><clinical relevance><clinically relevant><cultured cell line><data interpretation><data mining><datamining><delta opioid receptor><depressed breathing><depression><depression of breathing><desensitization><design><designing><drug development><drug/agent><electrophysiological><endogenous opiate><endogenous opioids><experiment><experimental research><experimental study><experiments><in vivo><large data sets><large datasets><mu opioid receptors><nano-molar><nanobodies><nanobody><nanomolar><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><opiate crisis><opiate use disorder><opioid associated apnea><opioid associated respiratory depression><opioid crisis><opioid epidemic><opioid induced hypoventilation><opioid induced respiratory depression><opioid mediated respiratory depression><opioid related respiratory depression><opioid respiratory depression><opioid use disorder><opioid ventilatory depression><pain intervention><pain killer><pain medication><pain reliever><pain treatment><painkiller><pathway><pro-enkephalin><prodynorphin><proenkephalin><protein kinase C kinase><receptor><receptor function><respiratory depression caused by opioids><respiratory depression due to opioids><respiratory mechanism><response><sdAb><secondary analysis><side effect><single domain antibodies><social role><substance use and disorder><synthetic drug><synthetic opiate><synthetic opioid><therapeutic agent development><therapeutic development><therapeutic target><trafficking><variable heavy chain antibody><ventral tegmentum><visual function><β-arrestin><δ OR><δ ORs><δ opioid receptors><δ-OR><δ-ORs><δOR><δORs><μ opioid receptors><μ-OR><μOR>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jennifer R Havens

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$482,290

FY 2026

Project Title

Examining the Impact of the Twin Epidemics of Methamphetamine and Opioid Use on Overdose, Risky Sex and Treatment Engagement among PWUD in Two Rural Appalachian Cohorts

Grant Number:

5R01DA033862-12

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2012

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT The goal of this R01 renewal is to examine the impact of methamphetamine (MA) use on fatal and nonfatal overdose, engagement in injection- and sex-risk behaviors, and treatment for opioid use disorder (OUD) and other substance use disorders (SUD) among people who use drugs (PWUD) from two A...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Takato Hiranita

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$427,285

FY 2026

Project Title

Gabapentinoid/opioid mixtures: abuse and toxicity

Grant Number:

5R01DA058018-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT/SUMMARY This application from a “New Investigator” is in response to Parent Announcement PA-20-185 “NIH Research Project Grant (Parent R01 Clinical Trial Not Allowed)” and requests 5 years of support to study the contribution of gabapentinoids to the opioid crisis. The number of opioid over...

Research Terms

<3-isobutyl GABA><Accounting><Actiq><Address><Adverse effects><Advocacy><American><Area><Assay><Attention><Attenuated><Autopsy><Behavior><Bioassay><Biological Assay><Breathing><Buprenorphine><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cessation of life><Classification><Clinical><Clinical Trials><Cocaine><Common Rat Strains><Convulsions><Data><Death><Dependence><Development><Diacetylmorphine><Diamorphine><Drug usage><Drugs><Duragesic><Epidemiological data><Epidemiology data><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Female><Fentanest><Fentanyl><Fentyl><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><General Population><General Public><Health><Heroin><History><Individual><Investigators><Life Expectancy><Literature><Medication><Morbidity><NIH><Naloxone><Narcan><Narcanti><National Institutes of Health><Neurontin><Opiate Addiction><Opiate Dependence><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid agonist><Opioid receptor agonist><Overdose><Parents><Patients><Pharmaceutical Preparations><Phentanyl><Physical Dependence><Pilot Projects><Policies><Predisposition><Procedures><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Rat><Rats Mammals><Rattus><Recording of previous events><Relaxation><Reporting><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Respiratory Aspiration><Respiratory Depression><Respiratory Inspiration><Risk><Risk Assessment><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Schedule><Seizures><Self Administered><Self Administration><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Stimulus><Substance Use Disorder><Susceptibility><Systematics><Testing><Time><Toxic effect><Toxicities><Toxicology><United States National Institutes of Health><Ventilatory Depression><Withdrawal><attenuate><attenuates><clinical relevance><clinically relevant><cocaine self-administration><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><depressed breathing><depression of breathing><developmental><drug discrimination><drug use><drug/agent><epidemiologic data><experience><fentanyl seeking><fentanyl self-administration><gabapentin><histories><inspiration><licit opioid><male><medication-assisted therapy><medication-assisted treatment><mortality><mu opioid receptors><naloxone dosing><necropsy><non-medical opioid use><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonmedical opioid use><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><off-label application><off-label prescribing><off-label use><opiate consumption><opiate crisis><opiate deaths><opiate drug use><opiate exposure><opiate intake><opiate medication><opiate misuse><opiate mortality><opiate overdose><opiate related overdose><opiate use><opiate withdrawal><opioid addiction><opioid associated apnea><opioid associated respiratory depression><opioid consumption><opioid crisis><opioid deaths><opioid dependence><opioid dependent><opioid detox><opioid detoxification><opioid drug overdose><opioid drug use><opioid epidemic><opioid exposure><opioid induced hypoventilation><opioid induced overdose><opioid induced respiratory depression><opioid intake><opioid intoxication><opioid mediated respiratory depression><opioid medication><opioid medication overdose><opioid misuse><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid related respiratory depression><opioid respiratory depression><opioid toxicity><opioid use><opioid ventilatory depression><opioid withdrawal><overdose death><overdose fatalities><pandemic><pandemic disease><parent><pilot study><postmortem><pregabalin><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><pressure><respiratory><respiratory depression caused by opioids><respiratory depression due to opioids><response><self-administer cocaine><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sex><substance use and disorder><μ opioid receptors><μ-OR><μOR><♀><♂>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Shahid Husain

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$421,439

FY 2026

Project Title

Opioid-Induced Epigenetic Mechanisms in Glaucoma

Grant Number:

5R01EY034514-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Glaucoma, a leading cause of blindness worldwide, is characterized by progressive loss of retinal ganglion cells (RGCs), an excavated appearance of the optic nerve, and vision loss. The etiology of glaucoma is complex, involving biomechanical stress, pro-inflammatory cytokines, deprivation of neurot...

Research Terms

<5-Azadeoxycytidine><5-deoxyazacytidine><ATAC sequencing><ATAC-seq><ATACseq><Acetylation><Acute><Affect><Agonist><Animals><Apoptotic><Appearance><Assay for Transposase-Accessible Chromatin using sequencing><Astrocytes><Astrocytus><Astroglia><Astroprotein><Attenuated><Autoregulation><BDNF><Basal Transcription Factor><Basal transcription factor genes><Binding><Biomechanics><Blindness><Brain-Derived Neurotrophic Factor><CREB><CREB1><CREB1 gene><Cataract><Causality><Cell Death><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Characteristics><Chromatin Structure><Chronic><Clinical Treatment><Common Rat Strains><Complex><CpG Islands><CpG-Rich Islands><Cranial Nerve II><Cranial Nerve II Diseases><Cranial Nerve II Disorder><DNA Methylation><DNA Methyltransferase><DNA Methyltransferase 3B><DNA Modification Methylases><DNA Modification Methyltransferases><DNA-Methyltransferases><DNMT3B gene><DNMT3a><DNMT3b><Data><Decitabine><Degenerative Neurologic Disorders><Deoxyazacytidine><Dependence><Dezocitidine><Diminished Vision><Dnmt><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Event><Exhibits><Eye><Eyeball><GFA-Protein><GFAP><Gene Expression><General Transcription Factor Gene><General Transcription Factors><Genes><Glaucoma><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Goals><HDAC><HDAC Proteins><Histone Acetylation><Histone Deacetylase><Histones><Homeostasis><Hypermethylation><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Inflammatory><Injury><Intraocular Pressure><Laboratories><Lead><Low Vision><Measures><Mediating><Methylation><Mice><Mice Mammals><Modeling><Modification><Modification Methylases><Molecular Interaction><Murine><Mus><Nerve Degeneration><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neural-Optical Lesion><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Norway Rats><Ocular Hypertension><Ocular Tension><Opiates><Opioid><Optic Disk><Optic Nerve><Optic Nerve Diseases><Optic Nerve Head><Optic Neuropathy><Optic Papilla><Outcome><POAG><Pain Control><Pain Therapy><Pain management><Partial Sight><Pathogenesis><Pathologic><Pathology><Pathway interactions><Patients><Pb element><Physiologic><Physiologic Intraocular Pressure><Physiological><Physiological Homeostasis><Primary Open Angle Glaucoma><Promoter Regions><Promotor Regions><RNA Seq><RNA sequencing><RNAseq><Rat><Rats Mammals><Rattus><Rattus norvegicus><Receptor Activation><Reduced Vision><Regulation><Retina><Retinal Ganglion Cells><Retinal Neuroblastoma><Retinoblastoma><Risk Factors><Role><STAT3><STAT3 gene><Second Cranial Nerve><Second Cranial Nerve Diseases><Site-Specific DNA-methyltransferase><Stress><Subcellular Process><Subnormal Vision><Testing><Therapeutic><Transcription Factor Proto-Oncogene><Transcription Initiation Site><Transcription Start Site><Transcription factor genes><Visual impairment><Work><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><astrocytic glia><attenuate><attenuates><biomechanical><cAMP Response Element-Binding Protein 1><cataractogenesis><cataractous lenses><causation><clinical intervention><clinical therapy><cytokine><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><delta opioid receptor><deprivation><disease causation><epigenetically><genetic promoter element><genetic promoter sequence><genome scale><genome-wide><genomewide><glaucomatous><hDNA methyltransferase 3a><hDNA methyltransferase 3b><heavy metal Pb><heavy metal lead><inhibitor><injuries><innovate><innovation><innovative><intra-ocular pressure><mRNA Expression><necrocytosis><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal degeneration><neuroprotection><neuroprotective><neurotrophic factor><neurotrophin><neutrophin><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><ocular hypertensive><optic nerve disorder><pain intervention><pain treatment><pathway><prevent><preventing><promoter sequence><protein expression><response><retina neuroblastoma><retinal ganglion><second cranial nerve disorder><social role><transcription factor><transcriptome sequencing><transcriptomic sequencing><trial regimen><trial treatment><vision impairment><vision loss><visual loss><visually impaired><δ OR><δ ORs><δ opioid receptors><δ-OR><δ-ORs><δOR><δORs>

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Mark E VonZastrow

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$375,858

FY 2026

Project Title

Mechanisms and Cellular Function of Opioid Receptor Endocytosis

Grant Number:

5R01DA012864-25

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/28/2000

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract Opioid and catecholamine receptors are key regulators of neurophysiology and behavior, and are important targets of therapeutic and abused drugs. These receptors all belong to the G protein-coupled receptor (GPCR) superfamily, the largest group of signaling receptors expressed in animals an...

Research Terms

<3'5'-cyclic ester of AMP><3,5 cyclic AMP synthetase><ADRBK1><ADRBK1 gene><Acceleration><Adaptor Protein><Adaptor Protein Gene><Adaptor Signaling Protein><Adaptor Signaling Protein Gene><Address><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adenyl Cyclase><Adenylate Cyclase><Adenylyl Cyclase><Agonist><Animals><Arrestins><Assay><BARK1><Bar Codes><Behavior><Beta-ARK-1><Binding><Bioassay><Biochemical><Biochemistry><Biological Assay><Biological Chemistry><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Catecholamine Receptors><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cell membrane><Cell model><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular biology><Cellular model><Cyclic AMP><Cytoplasm><Cytoplasmic Domain><Cytoplasmic Membrane><Cytoplasmic Receptors><Cytoplasmic Tail><DNA mutation><Dependence><Diacetylmorphine><Diamorphine><Diffuse><Disparate><Dissociation><Drug Regulations><Drug Targeting><Drugs><Endocytosis><Endosomes><Equilibrium><Foundations><Funding><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G Protein-Coupled Receptor Kinase Family><G Protein-Coupled Receptor Signaling><G protein coupled receptor kinase><G-Protein-Coupled Receptors><G-Proteins><GPCR><GPCR Signaling><GRK><GRK2><GTP-Binding Proteins><GTP-Regulatory Proteins><Genetic Change><Genetic defect><Genetic mutation><Goals><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><Heroin><Individual><Infumorph><Intracellular Communication and Signaling><Intracellular Membranes><Isoforms><Kadian><Knowledge><Ligands><Location><MS Contin><MSir><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Medication><Methods><Molecular><Molecular Interaction><Morphia><Morphine><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuromodulator Receptors><Neurons><Neuropeptides><Opiate Receptors><Opiates><Opioid><Opioid Receptor><Oramorph><Oramorph SR><Pathologic><Pathology><Pattern><Pharmaceutical Preparations><Phosphorylation><Phosphorylation Site><Physiologic><Physiological><Plasma Membrane><Process><Production><Protein Engineering><Protein Isoforms><Protein Phosphorylation><Proteins><Receptor Activation><Receptor Protein><Receptor Signaling><Receptosomes><Regulation><Research><Retinal S-Antigen><Role><Roxanol><Signal Transduction><Signal Transduction Systems><Signaling><Statex SR><Structural Protein><Subcellular Process><Tail><Testing><Therapeutic><abused drug><abused drugs><adapter protein><addiction><addictive disorder><adenosine 3'5' monophosphate><arrestin B><balance><balance function><barcode><beta-arrestin><biological signal transduction><cAMP><cell biology><coated pit><drug abused><drug action><drug discovery><drug discrimination><drug of abuse><drug/agent><drugs abused><drugs of abuse><endogenous opiate><endogenous opioids><flexibility><flexible><fundamental research><genetic protein engineering><genome mutation><insight><neural circuit><neural circuitry><neurocircuitry><neuronal><neurophysiological><neurophysiology><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><operation><operations><opiate tolerance><opioid habituation><opioid tolerance><plasmalemma><programs><protein activation><protein design><receptor><receptor-mediated signaling><recruit><social role><spatial and temporal><spatial temporal><spatiotemporal><structural determinants><structural factors><synaptic circuit><synaptic circuitry><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tolerance to opiates><trafficking><β-arrestin>

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Peter F Rebeiro

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$371,875

FY 2026

Project Title

Harnessing big data to arrest the HIV/HCV/opioid syndemic in the rural and urban South

Grant Number:

5R01DA057129-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary / Abstract The HIV, HCV, and opioid epidemics disparately impact populations in different regions of the US, with higher burden (51% of new HIV diagnoses in the US) and poorer outcomes (highest HIV mortality in the US, at 6-10 per 1,000 persons with HIV) in the South, particularly l...

Research Terms

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James M Otis

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$339,750

FY 2026

Project Title

Thalamostriatal Circuitry in Opioid Seeking

Grant Number:

5R01DA054271-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY/ABSTRACT Reward-associated cues are unlikely to provoke reward seeking when that behavior is inappropriate, yet cues elicit opioid seeking in patients with opioid use disorder (OUD) when that behavior is unproductive or maladaptive. There is little understanding of how brain systems that can...

Research Terms

<2-photon><Assay><Behavior><Behavioral><Behavioral Assay><Behavioral Paradigm><Bioassay><Biological Assay><Brain><Brain Nervous System><Calcium><Conflict><Conflict (Psychology)><Consumption><Cues><Data><Diacetylmorphine><Diamorphine><Drug usage><Drugs><Electrophysiology><Electrophysiology (science)><Encephalon><Extinction><Fear><Feeding behaviors><Fright><Head><Health><Heroin><Image><In vivo two-photon calcium imaging><Ingestive Behavior><Knowledge><Laboratories><Literature><Maintenance><Measures><Medication><Mice><Mice Mammals><Motivation><Murine><Mus><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nucleus Accumbens><Opiates><Opioid><Paraventricular Nucleus of Thalamus><Paraventricular Thalamic Nucleus><Pathway interactions><Patients><Pharmaceutical Preparations><Phase><Publications><Relapse><Research><Rest><Rewards><Saline><Saline Solution><Satiation><Scientific Publication><Self Administered><Self Administration><Slice><Stimulus><Structure of paraventricular nucleus of thalamus><Synapses><Synaptic><System><Testing><Thalamic structure><Thalamus><addiction><addictive disorder><drug use><drug/agent><electrophysiological><experience><experiment><experimental research><experimental study><experiments><feeding><feeding-related behaviors><heroin intake><heroin use><imaging><in vivo calcium imaging><insight><mu opioid receptors><neurobiological><neuronal><neuronal circuit><neuronal circuitry><neurophysiological><neurophysiology><novel><nutrient intake activity><opiate consumption><opiate drug use><opiate intake><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid intake><opioid use><opioid use disorder><optogenetics><patch clamp><pathway><relapse prediction><restraint><reward anticipation><satiety><synapse><thalamic><two-photon><μ opioid receptors><μ-OR><μOR>

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Mamoun M Alhamadsheh

UNIVERSITY OF THE PACIFIC-STOCKTON, STOCKTON, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$337,500

FY 2026

Project Title

A novel drug delivery system for the prevention and rescue of fentanyl and other opioid overdoses

Grant Number:

5R01DA058024-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Opioids have significant adverse effects highlighted by the large number of patients with opioid use disorder (OUD) and the increasing number of overdose deaths in the United States and elsewhere. In just the 12-month period ending in November 2021, more than 107,000 Americans died from drug overdos...

Research Terms

<4-methoxycarbonyl fentanyl><4-methoxycarbonylfentanyl><Actiq><Adderall><Adderall XR><Adverse effects><American><Antidotes><Armed Forces Personnel><BBB crossing><BBB penetration><Binding><Blood Serum><Brain><Brain Nervous System><Buprenorphine><Cessation of life><Cocaine><Common Rat Strains><Crystal Meth><Crystal methamphetamine><Dangerousness><Death><Deoxyephedrine><Desoxyephedrine><Development><Diacetylmorphine><Diamorphine><Dose><Drug Delivery><Drug Delivery Systems><Drug Kinetics><Drug Precursors><Drugs><Duragesic><Encephalon><Ensure><Esters><Evaluation><FDA approved><Fentanest><Fentanyl><Fentyl><Funding><Generations><Goals><Happiness><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Heroin><Human Resources><Hybrids><Hydrolysis><Hypodermis><Illicit Drugs><In Vitro><Infumorph><Ingestion><Kadian><Law Enforcement><Life><Ligands><Liver Cells><MS Contin><MSir><Manpower><Medication><Metabolic><Methamphetamine><Methylamphetamine><Military><Military Personnel><Molecular Interaction><Monitor><Morphia><Morphine><N-Methylamphetamine><Naloxone><Narcan><Narcanti><NuAlpraz><Opiate Antagonist><Opiate receptor antagonist><Opiates><Opioid><Opioid Antagonist><Opioid receptor antagonist><Oramorph><Oramorph SR><Overdose><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Percocet><Persons><Pharmaceutical Preparations><Pharmacokinetics><Phase><Phentanyl><Prealbumin><Precipitation><Prevention><Pro-Drugs><Proalbumin><Prodrugs><Public Health><Rat><Rats Mammals><Rattus><Renal clearance function><Reporting><Respiration><Risk><Roxanol><Safety><School-Age Population><Series><Serum><Serum Proteins><Statex SR><Subcutaneous Tissue><Subcutis><Superficial Fascia><System><Tafil><Tela Subcutanea><Testing><Theriacs><Time><Toxic effect><Toxicities><Trankimazin><Transthyretin><United States><Whole Body Plethysmography><Withdrawal Symptom><Xanax><absorption><antagonism><antagonist><blood-brain barrier crossing><blood-brain barrier penetration><bloodbrain barrier crossing><bloodbrain barrier penetration><carfentanil><carfentanyl><design><designing><determine efficacy><developmental><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy testing><evaluate efficacy><examine efficacy><fentalogs><fentalogues><fentanyl analog><fentanyl overdose><first responder><high school><hydrophilicity><in vivo><ingest><mass casualty><meth><military population><milligram><mu opioid receptors><nalmefene><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><opiate crisis><opiate deaths><opiate mortality><opiate overdose><opiate related overdose><opiate use disorder><opiate withdrawal><opioid associated apnea><opioid associated respiratory depression><opioid crisis><opioid deaths><opioid detox><opioid detoxification><opioid drug overdose><opioid epidemic><opioid induced hypoventilation><opioid induced overdose><opioid induced respiratory depression><opioid intoxication><opioid mediated respiratory depression><opioid medication overdose><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid related respiratory depression><opioid respiratory depression><opioid toxicity><opioid use disorder><opioid ventilatory depression><opioid withdrawal><overdose death><overdose fatalities><patient oriented outcomes><personnel><pill><precipitations><prevent><preventing><renal clearance><respiratory depression caused by opioids><respiratory depression due to opioids><respiratory mechanism><school age><side effect><subcutaneous><subdermal><subdermal tissue><synthetic opiate><synthetic opioid><weapons><μ opioid receptors><μ-OR><μOR>

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YIH-ING HSER

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 56/100

Above-average budget

Very recent

Active award

Team-scale grant

$912,195

FY 2026

Project Title

Greater Southern California Node of the Clinical Trials Network

Grant Number:

5UG1DA049435-07

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2019

End Date:

2/29/2032

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction. The ove...

Research Terms

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Larissa Jeanette Mooney

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 56/100

Above-average budget

Very recent

Active award

Team-scale grant

$912,195

FY 2026

Project Title

Greater Southern California Node of the Clinical Trials Network

Grant Number:

5UG1DA049435-07

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2019

End Date:

2/29/2032

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction. The ove...

Research Terms

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TRACI C GREEN

RHODE ISLAND HOSPITAL, PROVIDENCE, RI

Good lead · 56/100

Above-average budget

Very recent

Active award

Team-scale grant

$539,118

FY 2026

Project Title

Navigating the Fentanyl Age with Community Drug Checking

Grant Number:

5UH3DA056881-04

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2022

End Date:

12/31/2027

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The drug supply is in enormous flux with illicitly manufactured fentanyl (IMF) and analogs creating a deadly environment for people who use drugs (PWUD). Claiming 93,311 lives in 2020, IMF is the underlying driver of the current crisis. Its fast onset leaves little time for emergency...

Research Terms

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Sarah Messmer

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$201,960

FY 2026

Project Title

Implementation of Contingency Management in a Mobile Low-Threshold Buprenorphine Clinic

Grant Number:

5K23DA060314-03

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract The overall goal of this proposed Mentored Patient-Oriented Research Career Development Award (K23) is for the candidate, Dr. Sarah Messmer, to become an independent investigator in implementation science and substance use disorder treatment, with a focus on opioid use disor...

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Devin Banks

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$198,288

FY 2026

Project Title

An Integrated Geospatial and Community-based Model to Prevent Opioid Overdose among Black Americans

Grant Number:

5K08DA058080-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

“Opioid overdose death (OOD) rates among Black Americans have increased unabated since 2015, outpacing national averages at a rate of two to one. Health disparities in the growth rate of OOD have been documented in at least 23 states, including Missouri, which has second highest rate of OOD among Bl...

Research Terms

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Neeraj Chhabra

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$197,835

FY 2026

Project Title

Machine learning approaches for the detection of emergency department patients with opioid misuse

Grant Number:

5K23DA055061-05

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Patients with opioid misuse disproportionately utilize emergency health services and are at increased risk for premature death. The timely and accurate identification of patients with opioid misuse in the Emergency Department (ED) is critical to provide evidence-based interv...

Research Terms

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Lauren Ingersoll Dayton

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$197,624

FY 2026

Project Title

Parents Who Misuse Opioids and have Dependent Children: Identifying and Mobilizing Social Network Members to Support Drug Treatment Engagement

Grant Number:

1K01DA065780-01

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Parental opioid misuse presents a critical public health challenge, with strong evidence linking opioid misuse among parents to adverse outcomes for both parents and their children. Engagement in drug treatment with medications for opioid use disorder (MOUD) is a key strateg...

Research Terms

<0-11 years old><21+ years old><Address><Adherence><Adult><Adult Human><Advanced Development><Affect><Area><Behavior><Belief><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Child><Child Mortality><Child Youth><Children (0-21)><Clinical><Communication><Communities><Data><Drug Therapy><Drug usage><Drugs><Emotional><Enrollment><Environment><Equipment and supply inventories><Ethics><Exposure to><Face><Family><Family member><Fear><Focus Groups><Friends><Fright><Funding><Goals><Health><Health Promotion><Individual><Institution><Intervention><Interview><Inventory><Investigators><K-Awards><K-Series Research Career Programs><Knowledge><Link><Literature><Maps><Materials Testing><Medication><Mentors><Mentorship><Methodology><Methods><Modeling><NIDA><NIH><National Institute of Drug Abuse><National Institute on Drug Abuse><National Institutes of Health><Network-based><Outcome><Parents><Personal Satisfaction><Persons><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Population><Public Health><Recovery><Recovery Support><Reporting><Research><Research Activity><Research Career Program><Research Personnel><Research Resources><Researchers><Resources><Salutogenesis><Science><Social Network><Social support><Stigmatization><Survey Instrument><Surveys><Testing><Training><United States National Institutes of Health><adulthood><adverse consequence><adverse outcome><barrier to care><barrier to health care><barrier to treatment><care giving><career><caregiving><drug intervention><drug treatment><drug use><drug/agent><enroll><ethical><evidence base><experience><faces><facial><implementation science><improved><improved outcome><informant><intervention mapping><kids><medication for opioid use disorder><member><multidisciplinary><non-medical opioid use><nonmedical opioid use><obstacle to care><obstacle to health care><opiate consumption><opiate drug use><opiate intake><opiate misuse><opiate use><opioid consumption><opioid drug use><opioid intake><opioid misuse><opioid use><parent><parent role><parental role><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><poor health outcome><pressure><promoting health><reduced health outcome><skills><social factors><social stigma><social support network><stigma><substance use><substance using><support network><well-being><wellbeing><worse health outcome><youngster>

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Frank Schwebel

UNIVERSITY OF NEW MEXICO, ALBUQUERQUE, NM

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$195,912

FY 2026

Project Title

Integrating Mindfulness and mHealth Approaches for Treating Opioid Use Disorder

Grant Number:

5K23DA058015-03

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract This Mentored Patient-Oriented Research Career Development application (K23) will provide protected time for Dr. Frank Schwebel to strengthen his trajectory as independent researcher at the University of New Mexico, Center on Alcohol, Substance use, And Addictions (UNM-CASAA...

Research Terms

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Ashish Prakash Thakrar

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$194,368

FY 2026

Project Title

Methadone Loading Dose Initiation for Hospitalized Patients with Opioid Use Disorder Using Fentanyl

Grant Number:

5K23DA062008-02

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/15/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Candidate: Ashish Thakrar, MD, MS, is an addiction medicine specialist, internal medicine physician, and clinician-scientist committed to improving care for individuals with substance use disorders (SUDs). His career goal is to become an independent investigator developing a...

Research Terms

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Marissa J Seamans

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$193,917

FY 2026

Project Title

Real-world complexities in opioid use disorder treatment: understanding family comorbidity, high-risk medication use, and costs related to treatment adherence and health outcomes

Grant Number:

5K01DA054359-05

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Medications for opioid use disorder (MOUD) have the potential to improve the health and well-being of more than 2.1 million Americans with OUD, however, long-term adherence particularly to buprenorphine is alarmingly poor. Pain, mental health, and substance use disorders are increasi...

Research Terms

<0-11 years old><Address><Adherence><Adverse Experience><Adverse event><American><Anxiety><Application Context><Benzodiazepine Compounds><Benzodiazepines><Buprenorphine><Child><Child Youth><Children (0-21)><Chronic depressive disorder><Clinical><Clinical assessments><Data><Data Analyses><Data Analysis><Data Bases><Databases><Development><Drug Prescribing><Drug Prescriptions><Drug Therapy><Drugs><ED visit><ER visit><Educational workshop><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><Environmental Factor><Environmental Risk Factor><Family><Family member><Foundations><Genetic><Goals><Health><Health Benefit><Health Care><Health Care Costs><Health Care Utilization><Health Costs><Health Insurance><Health Insurance Reimbursement><Health Services Evaluation><Health Services Research><Health Status><History><Hospital Admission><Hospitalization><Household><Improve Access><Incidence><Individual><Insurance Carriers><Insurers><Intervention><Investigators><K01 Award><K01 Mechanism><K01 Program><Knowledge><Learning><Level of Health><Life><Married Persons><Medical Care Research><Medication><Medicine><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mentored Research Scientist Development Award><Mentored Training Award><Mentors><Mentorship><Methods><Muscle relaxants><Opiates><Opioid><Out-of-Pocket Expense><Outcome><Overdose><Pain><Painful><Parents><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Personal Satisfaction><Persons><Pharmaceutical Epidemiology><Pharmaceutical Preparations><Pharmacoepidemiology><Pharmacological Treatment><Pharmacotherapy><Play><Policies><Privatization><Psychiatric Disease><Psychiatric Disorder><Psychiatry><Psychological Health><Public Health><Publishing><Recording of previous events><Research><Research Personnel><Research Scientist Development Award><Researchers><Risk><Risk Factors><Role><Serious Adverse Event><Severe Adverse Event><Siblings><Spouses><Stimulant><Substance Use Disorder><Third-Party Payments><Time><Training><Uncovered Medical Expenses><Uncovered Uninsured Medical Expense><Uninsured Medical Expense><Workshop><access to medications><addiction><addictive disorder><adverse consequence><adverse outcome><alcohol use disorder><beneficiary><buprenorphine treatment><career><chronic depression><chronic pain><clinical care><clinical decision support><clinical diagnosis><clinical practice><clinical predictive model><clinical relevance><clinically relevant><co-morbid><co-morbidity><comorbidity><computer based prediction><contextual factors><cost><data base><data interpretation><data warehouse><depression><design><designing><developmental><drug adherence><drug compliance><drug epidemiology><drug intervention><drug misuse><drug treatment><drug/agent><economic analysis><economic assessment><economic evaluation><environmental risk><ethanol use disorder><health care service use><health care service utilization><health insurance plan><health level><health plan><health plans><high risk><histories><improved><indexing><innovate><innovation><innovative><insight><insurance claims><kids><medical expenses not covered by insurance><medication access><medication adherence><medication compliance><medication for opioid use disorder><medication misuse><medication prescription><meeting><meetings><mental illness><opiate consumption><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><out-of-pocket costs><out-of-pocket health care costs><parent><patient oriented outcomes><payment policy><pharmaceutical intervention><pharmacoepidemiologic><pharmacoepidemiological><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><predictive modeling><prescribed medication><psychiatric illness><psychological disorder><psychosocial><reimbursement policy><responsible research conduct><sedative><serious adverse experience><serious adverse reaction><services research><skills><social role><substance use and disorder><substance use treatment><support tools><total medical expenditure><treatment adherence><treatment compliance><well-being><wellbeing><youngster>

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John Richard Pamplin

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$192,710

FY 2026

Project Title

Evaluating the role of local context in the effectiveness of state-level overdose prevention policies

Grant Number:

5K01DA058085-04

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Deaths due to opioid overdose are a pressing public health crisis and the number of deaths per year is increasing, largely driven by the increased prominence of synthetic opioids. Interventions are critically needed that can effectively reduce overdose mortality. Overdose prevention policies (OPPs) ...

Research Terms

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Melissa Kari Ward

FLORIDA INTERNATIONAL UNIVERSITY, MIAMI, FL

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$189,865

FY 2026

Project Title

The Women-Centered Opioid Recovery Project: Advancing women's engagement in care for opioid use disorder through development of a novel recovery navigation system led by women in recovery

Grant Number:

5K01DA055820-05

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT The opioid crisis has escalated dramatically among women: from 1999 to 2019, the rate of opioid-related overdoses among females increased from 1.4 to 9.3 per 100,000 population. Women face many unique challenges in obtaining treatment for opioid use disorder (OUD). These ba...

Research Terms

<0-11 years old><AIDS Virus><Access to Care><Accounting><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><American><Award><Awareness><COVID-19><CV-19><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Child><Child Custodies><Child Custody><Child Youth><Children (0-21)><Chronic><Clinical><Coronavirus Infectious Disease 2019><Data><Development><Differences between sexes><Differs between sexes><Disparities><Disparity><Evidence based intervention><Evidence based program><Face><Family member><Female><Focus Groups><Gestation><Goals><HIV><Health><Health Care Providers><Health Personnel><Health Services Accessibility><Human Immunodeficiency Viruses><Hybrids><Intervention><Interview><Investigators><K-Awards><K-Series Research Career Programs><LAV-HTLV-III><Life Cycle><Life Cycle Stages><Lymphadenopathy-Associated Virus><Mental Health><Mental Hygiene><Mentorship><Methods><Navigation System><Neonatal Abstinence Syndrome><Neonatal Opioid Withdrawal Syndrome><Neonatal Substance Withdrawal><Neonatal Withdrawal Syndrome><Neurobiology><On-Line Systems><Online Systems><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Outcome><Participant><Persons><Population><Position><Positioning Attribute><Pregnancy><Psychological Health><Randomized><Recovery><Research><Research Career Program><Research Personnel><Research Resources><Researchers><Resources><Services><Sex Differences><Sexual differences><Shame><Structure><Survey Instrument><Surveys><Virus-HIV><Vulnerable Populations><Woman><access to health services><access to services><access to treatment><accessibility to health services><addiction><addictive disorder><after pregnancy><availability of services><barrier to care><barrier to health care><barrier to treatment><care access><care seeking><co-morbid><co-morbidity><community engaged intervention><community engaged participatory research><community engaged research><community informed intervention><community led intervention><community partnered research><community-driven intervention><community-engaged study><community-partnered intervention><community-partnered study><comorbidity><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><develop therapy><developmental><evidence base><experience><faces><facial><female outcomes><health care personnel><health care worker><health provider><health service access><health services availability><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><improved><improved outcome><internet based platform><internet platform><intervention design><intervention development><kids><life course><medical care providers><medical complication><medical personnel><meeting><meetings><men><neurobiological><newborn abstinence syndrome><novel><obstacle to care><obstacle to health care><online computer><opiate consumption><opiate crisis><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid addiction><opioid consumption><opioid crisis><opioid dependence><opioid dependent><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><outcomes among females><outcomes among women><outcomes in females><outcomes in women><patient navigator><post pregnancy><programs><prototype><public health emergency><randomisation><randomization><randomly assigned><scale up><service availability><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><theories><therapy design><therapy development><treatment access><treatment design><treatment development><treatment provider><usability><virtual><vulnerable group><vulnerable individual><vulnerable people><web based><web based platform><web based system><web enabled platform><web platform><web tool><web-based tool><women's outcomes><youngster><♀>

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Bryant Shuey

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$189,463

FY 2026

Project Title

Lowering Cardiovascular Disease Among People with Opioid Use Disorder

Grant Number:

5K23DA062822-02

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/15/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Cardiovascular disease (CVD) is the leading cause of non-overdose death among people with opioid use dis- order (OUD). Hypertension (HTN) is a modifiable individual risk factor for CVD, with HTN medications reducing major adverse cardiovascular events (MACE) up to 25% compared to no treatme...

Research Terms

<21+ years old><Active Learning><Address><Adult><Adult Human><Affect><Attitude><Buprenorphine><CVD prevention><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Caring><Centers for Medicare and Medicaid Services><Chronic Disease><Chronic Illness><Clinical><Comprehensive Health Care><Cooperative Learning><Cox Proportional Hazards Models><Data><Data Files><Data Systems><Development Plans><Development and Research><Diabetes Mellitus><Diagnosis><Disease Management><Disorder Management><Drug usage><Drugs><Evaluation><Event><Experiential Learning><Face><Future><Goals><Health><Health Care Financing Administration><Health Services><Health Services Evaluation><Health Services Research><Heart Vascular><High Prevalence><Home><Hyperlipemia><Hyperlipidemia><Hypertension><IT Systems><Improve Access><Individual><Information Systems><Information Technology Systems><Intervention><Interview><Investigation><Investigators><K12><K12 Award><K12 Mechanism><K12 Program><Link><Literature><Managed Care><Medicaid><Medical><Medical Care Research><Medication><Mentored Clinical Scientist Development Program><Mentors><Methodology><Methods><Modeling><NHLBI><NIDA><National Heart, Lung, and Blood Institute><National Institute of Drug Abuse><National Institute on Drug Abuse><Outcome><Patient-Centered Care><Patients><Persons><Pharmaceutical Preparations><Policies><Policy Research><Population><Predisposition><Prevalence><Probability><Provider><Public Health><Qualitative Methods><Qualitative Research><Quasi-experiment><Quasi-experimental analysis><Quasi-experimental approach><Quasi-experimental design><Quasi-experimental methods><Quasi-experimental research><Quasi-experimental study><Quasi-experimental technique><R & D><R&D><Research><Research Personnel><Researchers><Risk><Risk Factors><Risk Reduction><Sampling><Services><Stigmatization><Structure><Substance Use Disorder><Susceptibility><Time><Tobacco><Tobacco Consumption><Tobacco use><Training><United States Centers for Medicare and Medicaid Services><United States Health Care Financing Administration><Variant><Variation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><addiction><addictive disorder><adulthood><adverse consequence><adverse outcome><behavioral health><cardiac disease prevention><cardiovascular disease prevention><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder prevention><cardiovascular disorder risk><cardiovascular risk><cardiovascular risk factor><care coordination><career><career development><chronic disorder><circulatory system><cohort><comprehensive care><coordinating care><diabetes><differences in health><drug use><drug/agent><experience><faces><facial><hazard><health and care delivery><health care delivery><health care quality><health delivery systems><health difference><health services delivery><high blood pressure><high risk group><high risk individual><high risk people><high risk population><homes><hyperpiesia><hyperpiesis><hypertension treatment><hypertensive disease><hypertensive disorder><improved><innovate><innovation><innovative><insight><integrated care><integrated health care><integrated model of care><mortality><non-drug><nondrug><novel><opiate use disorder><opioid treatment program><opioid use disorder><overdose death><overdose fatalities><patient barriers><patient-level barriers><payment><prevent><preventing><primary care provider><programs><provider barriers><provider-level barriers><providers from primary care><providers of primary care><psychostimulant use><qualitative reasoning><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><research and development><risk-reducing><services research><stimulant use><substance use and disorder><tobacco product use><tool><use of stimulants>

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Brian Chan

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$174,387

FY 2026

Project Title

Identifying High Utilizing Patients with Opioid Use Disorder to Engage in Primary Care

Grant Number:

5K23DA053390-05

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Brian Chan MD MPH is an internist and health services researcher passionate about improving health outcomes for vulnerable patients with opioid use disorder (OUD). This career development award will establish Dr. Chan as a clinician-investigator focused on implementing and ...

Research Terms

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Katherine Guyon-Harris

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$153,233

FY 2026

Project Title

Promoting positive parenting among pregnant women with opioid use disorder

Grant Number:

5K23DA055092-05

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The overarching goal of my program of research is to develop and inform preventive interventions to improve parent–child outcomes for families affected by substance use. The focus of this K23 award is to inform and adapt an evidenced-based preventive parenting intervention, the Famil...

Research Terms

<0-11 years old><2nd trimester><3rd trimester><Address><Affect><Age><Anxiety><Birth><Care Givers><Caregivers><Check-up><Child><Child Rearing><Child Welfare><Child Youth><Children (0-21)><Clinical><Clinical Research><Clinical Study><Clinical Trials><Complex><Data><Dedications><Development><Discipline of obstetrics><Drug usage><Ensure><Evidence based intervention><Family><Female Health><Fostering><Gestation><Goals><Gynecologist><Health Care Providers><Health Personnel><History><Infant Care><Interpersonal Interaction><Interpersonal Relations><Intervention><Interview><Investigators><K23 Award><K23 Mechanism><K23 Program><Knowledge><Last Trimester><Learning><Link><Mental Depression><Mental Health><Mental Hygiene><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentors><Methods><Midtrimester><Modeling><Modification><Mothers><Motivation><Obstetrics><Outcome><Parent-Child Relations><Parent-Child Relationship><Parenting><Parenting Education><Parenting behavior><Parents><Participant><Parturition><Pediatrics><Perinatal><Peripartum><Pilot Projects><Population><Population Intervention><Position><Positioning Attribute><Postpartum Period><Pregnancy><Pregnant Women><Preventative intervention><Preventative service><Prevention><Preventive><Preventive service><Primary Care><Psychological Health><Psychologist><Psychology><Qualitative Research><Recording of previous events><Recovery><Research><Research Methodology><Research Methods><Research Personnel><Researchers><Science><Second Pregnancy Trimester><Second Trimester><Self Efficacy><Site><Social support><Stress><Symptoms><Testing><Thinking><Third Pregnancy Trimester><Third Trimester><Training><Trauma><Trust><Woman><Women's Health><Work><adolescent welfare><ages><baby care><care giver functioning><care giving><caregiver functioning><caregiving><checkup><checkup examination><child well being><child wellbeing><childrearing><community partners><community-based partners><depression><design><designing><developmental><drug use><evidence base><expectant mother><expectant women><expecting mother><expecting women><experience><family support><feasibility testing><feeding><female outcomes><flexibility><flexible><health care personnel><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><histories><improved><individuals who are pregnant><infancy><infant health care><infantile><interpersonal relationship><intervention for prevention><kids><medical care providers><medical personnel><motivational enhancement therapy><motivational interview><newborn care><opiate consumption><opiate drug use><opiate intake><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid intake><opioid use><opioid use disorder><outcomes among females><outcomes among women><outcomes in females><outcomes in women><parent><parent child interaction><parent offspring interaction><parenting education intervention><parenting education programs><parenting intervention><parenting program><parenting skill training><parenting training><people who are pregnant><perinatal mental health><perinatal period><perinatal phase><pilot study><pilot test><population based intervention><population specific intervention><post-partum><postnatal><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal><prenatal intervention><prevent><preventing><prevention intervention><preventional intervention strategy><preventive intervention><primary care setting><programs><psychosocial><recruit><research and methods><skills><social support network><substance use><substance use treatment><substance using><those who are pregnant><thoughts><treatment provider><treatment services><unborn><women who are pregnant><women's outcomes><youngster>

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Scott Evan Hadland

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 56/100

Likely hiring

Very recent

Active award

$133,997

FY 2026

Project Title

The Cascade of Care for Medicaid-Enrolled Youth with Opioid Use Disorder

Grant Number:

3R01DA057566-04S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2022

End Date:

7/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

MODIFIED PROJECT SUMMARY/ABSTRACT SECTION Two-thirds of individuals with opioid use disorder (OUD) first misuse opioids before age 25. Intervention early in the life course is critical, and requires that adolescents and young adults (hereafter, “youth”) receive high- quality care in a continuum of c...

Research Terms

<12-20 years old><13 year old><13 years of age><Accident and Emergency department><Address><Adolescence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Age><Alcohol Chemical Class><Alcohols><Approaches to prevention><Cannabis><Caring><Characteristics><Claims Analyses><Claims Analysis><Claims Review><Climate><Clinical><Continuity of Care><Continuity of Patient Care><Continuum of Care><Counseling><County><D.C. Washington><DC Washington><Data><Data Bases><Data Systems><Databases><Diagnosis><District of Columbia><Drugs><Early Intervention><Emergency Department><Emergency room><Enrollment><Ensure><Family><Funding><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><Grant><Health Care><Health Care Systems><Health Care Utilization><Health Services Evaluation><Health Services Research><History><Hospital Admission><Hospitalization><IT Systems><Individual><Information Systems><Information Technology Systems><Infrastructure><Injury><Inpatients><Insurance Claim Review><Interdisciplinary Research><Interdisciplinary Study><Intervention><Investigators><Knowledge><Legal><Life Cycle><Life Cycle Stages><Link><Lived experience><Lived experiences><Location><Measures><Medicaid><Medical Care Research><Medication><Mental Health><Mental Hygiene><Meteorological Climate><Multidisciplinary Collaboration><Multidisciplinary Research><Nicotine><Out-patients><Outcome><Outpatients><Overdose><Pain><Painful><Pathway interactions><Pattern><Pharmaceutical Preparations><Pharmacies><Pharmacy facility><Policies><Population><Position><Positioning Attribute><Preventative intervention><Preventative strategy><Prevention approach><Prevention strategy><Preventive strategy><Primary Care><Psychological Health><QOC><Quality of Care><Recording of previous events><Research><Research Personnel><Research Support><Researchers><Risk><Risk Factors><Role><Rural><Series><Subgroup><Substance Use Disorder><US State><Visit><Work><World Health><Youth><Youth 10-21><addiction><addictive disorder><adolescence (12-20)><adult youth><age 13><age 13 years><ages><behavioral health><climatic><clinical care><clinical encounter><cohort><community engagement><data base><drug/agent><engagement with communities><enroll><experience><falls><geographic site><health care service use><health care service utilization><histories><improved><injuries><insight><intervention for prevention><juvenile><juvenile human><life course><long-term recovery><medication for opioid use disorder><non-medical opioid use><nonmedical opioid use><novel><operation><operations><opiate consumption><opiate drug use><opiate intake><opiate misuse><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid misuse><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><overdose death><overdose fatalities><overdose prevention><pathway><prevent><preventing><prevention intervention><preventional intervention strategy><preventive intervention><programs><protocol development><public health relevance><rural area><rural location><rural region><services research><social role><socio-demographics><sociodemographics><substance use><substance use and disorder><substance using><thirteen year old><thirteen years of age><treatment program><urban area><urban location><urban region><young adult><young adult age><young adulthood><youth age>

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Jason Richard Paris

UNIVERSITY OF MISSISSIPPI, UNIVERSITY, MS

Good lead · 56/100

Likely hiring

Very recent

Active award

$101,214

FY 2026

Project Title

Ionic liquid-assisted drug delivery to brain reservoirs for treatment of neuroHIV

Grant Number:

3R01DA056875-03S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/3/2026

End Date:

5/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Despite the success of antiretroviral therapeutics (ARTs), they cannot eradicate HIV from reservoirs within the body, particularly those in the central nervous system (CNS). Moreover, opioids upregulate efflux transporters further promoting subtherapeutic concentrations of ART in the CNS. We...

Research Terms

<3TC><ABC20><ABCB1><ABCB1 gene><AIDS Virus><AMES mutagen test><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Acute><Affinity><Ames Assay><Ames Salmonella/microsome mutagenicity assay><Ames Test><Anions><Anti-Retroviral Agents><Assay><Astrocytes><Astrocytus><Astroglia><Attenuated><Bioassay><Biochemical><Biocompatible Materials><Biodistribution><Biological><Biological Assay><Biomaterials><Blood><Blood - brain barrier anatomy><Blood Plasma><Blood Reticuloendothelial System><Blood erythrocyte><Blood-Brain Barrier><Body Tissues><Brain><Brain Nervous System><Brain region><CNS Nervous System><CNS agent><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cations><Cell Adhesion><Cell Body><Cells><Cellular Adhesion><Central Nervous System><Central Nervous System Agents><Central Nervous System Drugs><Chemistry><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Common Rat Strains><Complete Blood Count><Complication><Data><Dependence><Dose><Drug Delivery><Drug Delivery Systems><Drug Efflux><Drug Kinetics><Drugs><Encephalon><Endothelial Cells><Engineering><Erythrocytes><Erythrocytic><Formulation><Future><GP170><Genes><Genetic Toxicity Tests><Genotoxicity Tests><Gliosis><Goals><Gold><HIV><HIV associated neurological disease><HIV associated neurological disorder><HIV cure><HIV functional cure><HIV replication><HIV viral replication><HIV-1 cure><HIV-1 functional cure><HIV-1 replication><HIV-1 viral replication><HIV-1 virus replication><HIV/AIDS cure><HPLC><Heart><Hemato-Encephalic Barrier><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Histopathology><Hortega cell><Hour><Human><Human Immunodeficiency Viruses><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><In Vitro><Infection><Infumorph><Infusion><Infusion procedures><Intracarotid><Intracarotid Infusion><Kadian><Kidney><Kidney Urinary System><Kinetics><LAV-HTLV-III><LC/MS><Lamivudine><Lead><Liquid substance><Liver><Lung><Lung Respiratory System><Lymphadenopathy-Associated Virus><M mulatta><M. mulatta><MDR-1><MDR1><MDR1 Protein><MS Contin><MSir><Macaca><Macaca mulatta><Macaca rhesus><Macaque><Marrow erythrocyte><Measures><Mediating><Medication><Methods><Microglia><Modeling><Modern Man><Monitor><Monkeys><Morphia><Morphine><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><Mutagen Screening><Mutagenicity Tests><NIR dye><Nerve Cells><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neuroimmune><Neurons><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Oral><Oramorph><Oramorph SR><Organ><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PBMC><PGY-1 Protein><PGY1><Pathology><Pb element><Peripheral Blood Mononuclear Cell><Pharmaceutical Preparations><Pharmacokinetics><Pharmacology><Plasma><Plasma Serum><Polymers><Precipitation><Primates><Primates Mammals><Prognosis><Proteins><Rat><Rats Mammals><Rattus><Red Blood Cells><Red Cell><Reporter><Research><Reticuloendothelial System, Serum, Plasma><Rhesus Macaque><Rhesus Monkey><Rodent Model><Roentgen Rays><Route><Roxanol><SIV><Safety><Salts><Sampling><Simian Immunodeficiency Viruses><Spleen><Spleen Reticuloendothelial System><Sprague-Dawley Rats><Statex SR><System><Testing><Therapeutic><Time><Tissues><Toxic effect><Toxicities><Treatment Efficacy><Viral><Viral Diseases><Virus Diseases><Virus-HIV><Work><X-Radiation><X-Ray Radiation><X-ray><Xray><Ziagen><abacavir><anti-retroviral><antiretroviral therapy><antiretroviral treatment><astrocytic glia><astrogliosis><attenuate><attenuates><biocompatibility><biologic><biological material><biomaterial compatibility><blood corpuscles><bloodbrain barrier><cell type><centrally acting drug><clinical development><cytokine><determine efficacy><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><fluid><gene editing method><gene editing methodology><gene editing strategy><gene editing techniques><gene-editing approach><gitter cell><gold nano particle><gold nanoparticle><heavy metal Pb><heavy metal lead><hepatic body system><hepatic organ system><human immunodeficiency virus cure><human immunodeficiency virus replication><human immunodeficiency virus-1 replication><improved><in vivo><in vivo Model><infusions><insight><intervention efficacy><light scattering><liquid><liquid chromatography mass spectrometry><liquid formulation><mesoglia><microglial cell><microgliocyte><mutagen testing><nano><nano gold><nano particle><nano particle delivery><nano polymer><nano-sized particle><nanoGold><nanoparticle><nanoparticle delivered><nanoparticle delivery><nanopolymer><nanosized particle><near IR dye><near infrared dye><neuro-AIDS><neuro-HIV><neuroAIDS><neuroHIV><neuronal><neuropathologic><neuropathological><neuropathology><non-human primate><nonhuman primate><novel><opiate exposure><opiate use disorder><opioid addiction><opioid dependence><opioid dependent><opioid exposure><opioid use disorder><particle><perivascular glial cell><polymer><polymeric><precipitations><preference><renal><reproductive><safety assessment><subcutaneous><subdermal><success><therapeutic efficacy><therapy efficacy><uptake><vector><viral infection><virology><virus infection><virus-induced disease>

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Eden Tanner

UNIVERSITY OF MISSISSIPPI, UNIVERSITY, MS

Good lead · 56/100

Likely hiring

Very recent

Active award

$101,214

FY 2026

Project Title

Ionic liquid-assisted drug delivery to brain reservoirs for treatment of neuroHIV

Grant Number:

3R01DA056875-03S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/3/2026

End Date:

5/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Despite the success of antiretroviral therapeutics (ARTs), they cannot eradicate HIV from reservoirs within the body, particularly those in the central nervous system (CNS). Moreover, opioids upregulate efflux transporters further promoting subtherapeutic concentrations of ART in the CNS. We...

Research Terms

<3TC><ABC20><ABCB1><ABCB1 gene><AIDS Virus><AMES mutagen test><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Acute><Affinity><Ames Assay><Ames Salmonella/microsome mutagenicity assay><Ames Test><Anions><Anti-Retroviral Agents><Assay><Astrocytes><Astrocytus><Astroglia><Attenuated><Bioassay><Biochemical><Biocompatible Materials><Biodistribution><Biological><Biological Assay><Biomaterials><Blood><Blood - brain barrier anatomy><Blood Plasma><Blood Reticuloendothelial System><Blood erythrocyte><Blood-Brain Barrier><Body Tissues><Brain><Brain Nervous System><Brain region><CNS Nervous System><CNS agent><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cations><Cell Adhesion><Cell Body><Cells><Cellular Adhesion><Central Nervous System><Central Nervous System Agents><Central Nervous System Drugs><Chemistry><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Common Rat Strains><Complete Blood Count><Complication><Data><Dependence><Dose><Drug Delivery><Drug Delivery Systems><Drug Efflux><Drug Kinetics><Drugs><Encephalon><Endothelial Cells><Engineering><Erythrocytes><Erythrocytic><Formulation><Future><GP170><Genes><Genetic Toxicity Tests><Genotoxicity Tests><Gliosis><Goals><Gold><HIV><HIV associated neurological disease><HIV associated neurological disorder><HIV cure><HIV functional cure><HIV replication><HIV viral replication><HIV-1 cure><HIV-1 functional cure><HIV-1 replication><HIV-1 viral replication><HIV-1 virus replication><HIV/AIDS cure><HPLC><Heart><Hemato-Encephalic Barrier><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Histopathology><Hortega cell><Hour><Human><Human Immunodeficiency Viruses><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><In Vitro><Infection><Infumorph><Infusion><Infusion procedures><Intracarotid><Intracarotid Infusion><Kadian><Kidney><Kidney Urinary System><Kinetics><LAV-HTLV-III><LC/MS><Lamivudine><Lead><Liquid substance><Liver><Lung><Lung Respiratory System><Lymphadenopathy-Associated Virus><M mulatta><M. mulatta><MDR-1><MDR1><MDR1 Protein><MS Contin><MSir><Macaca><Macaca mulatta><Macaca rhesus><Macaque><Marrow erythrocyte><Measures><Mediating><Medication><Methods><Microglia><Modeling><Modern Man><Monitor><Monkeys><Morphia><Morphine><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><Mutagen Screening><Mutagenicity Tests><NIR dye><Nerve Cells><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neuroimmune><Neurons><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Oral><Oramorph><Oramorph SR><Organ><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PBMC><PGY-1 Protein><PGY1><Pathology><Pb element><Peripheral Blood Mononuclear Cell><Pharmaceutical Preparations><Pharmacokinetics><Pharmacology><Plasma><Plasma Serum><Polymers><Precipitation><Primates><Primates Mammals><Prognosis><Proteins><Rat><Rats Mammals><Rattus><Red Blood Cells><Red Cell><Reporter><Research><Reticuloendothelial System, Serum, Plasma><Rhesus Macaque><Rhesus Monkey><Rodent Model><Roentgen Rays><Route><Roxanol><SIV><Safety><Salts><Sampling><Simian Immunodeficiency Viruses><Spleen><Spleen Reticuloendothelial System><Sprague-Dawley Rats><Statex SR><System><Testing><Therapeutic><Time><Tissues><Toxic effect><Toxicities><Treatment Efficacy><Viral><Viral Diseases><Virus Diseases><Virus-HIV><Work><X-Radiation><X-Ray Radiation><X-ray><Xray><Ziagen><abacavir><anti-retroviral><antiretroviral therapy><antiretroviral treatment><astrocytic glia><astrogliosis><attenuate><attenuates><biocompatibility><biologic><biological material><biomaterial compatibility><blood corpuscles><bloodbrain barrier><cell type><centrally acting drug><clinical development><cytokine><determine efficacy><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><fluid><gene editing method><gene editing methodology><gene editing strategy><gene editing techniques><gene-editing approach><gitter cell><gold nano particle><gold nanoparticle><heavy metal Pb><heavy metal lead><hepatic body system><hepatic organ system><human immunodeficiency virus cure><human immunodeficiency virus replication><human immunodeficiency virus-1 replication><improved><in vivo><in vivo Model><infusions><insight><intervention efficacy><light scattering><liquid><liquid chromatography mass spectrometry><liquid formulation><mesoglia><microglial cell><microgliocyte><mutagen testing><nano><nano gold><nano particle><nano particle delivery><nano polymer><nano-sized particle><nanoGold><nanoparticle><nanoparticle delivered><nanoparticle delivery><nanopolymer><nanosized particle><near IR dye><near infrared dye><neuro-AIDS><neuro-HIV><neuroAIDS><neuroHIV><neuronal><neuropathologic><neuropathological><neuropathology><non-human primate><nonhuman primate><novel><opiate exposure><opiate use disorder><opioid addiction><opioid dependence><opioid dependent><opioid exposure><opioid use disorder><particle><perivascular glial cell><polymer><polymeric><precipitations><preference><renal><reproductive><safety assessment><subcutaneous><subdermal><success><therapeutic efficacy><therapy efficacy><uptake><vector><viral infection><virology><virus infection><virus-induced disease>

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Ryan Sean Phillips

SEATTLE CHILDREN'S HOSPITAL, SEATTLE, WA

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$100,975

FY 2026

Project Title

Dissociating respiratory depression and analgesia via a data-driven model of interacting respiratory and pain networks

Grant Number:

5K01DA058543-04

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY This mentored research scientist development award will allow the candidate, Dr. Ryan Phillips, to establish an independent research career focused on understanding the complex circuit interactions that link pain and respiration. The training plan outlined in this award, combined wit...

Research Terms

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Suky Martinez

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$75,600

FY 2026

Project Title

Natural Language Processing Phenotyping of Spirituality and Resilience Among Individuals with Opioid Use Disorder

Grant Number:

3K08DA058057-02S1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2026

End Date:

6/30/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Despite vast economic investments to mitigate the harms of opioid use disorder (OUD), the prevalence of the disorder remains high in addition to an estimated 80,000 Americans dying from opioid-related overdoses yearly. Given the significant heterogeneity across multiple dimensions of...

Research Terms

<0-11 years old><AI Augmented><AI assisted><AI based method><AI driven><AI enhanced><AI integrated><AI powered><Administrative Supplement><Affective><American><Artificial Intelligence enhanced><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Award><Behavior><Behavioral><Birth><Blood Pressure><Cardiac Chronotropism><Causality><Cessation of life><Child><Child Youth><Children (0-21)><Cognitive><Computer Models><Computerized Models><DSM-5><DSM-V><DSM5><Data><Death><Decision Making><Development><Diagnostic and Statistical Manual of Mental Disorders, 5th edition><Diagnostic and Statistical Manual of Mental Disorders-V><Dimensions><Disease><Disorder><Drugs><Economics><Electrodermal Response><Emotional><Emotions><Etiology><Event><Fathers><Force of Gravity><Funding><Future><Galvanic Skin Response><Goals><Grant><Gravities><Heart Rate><Heterogeneity><Human><Individual><Infrastructure><Intervention><Interview><Investigation><Investments><Laboratories><Laboratory Procedures><Life><Linguistic><Linguistics><Manuscripts><Measurement><Measures><Medication><Mentors><Methodology><Methods><Modeling><Modern Man><Natural Language Processing><Opiates><Opioid><Out-patients><Outcome><Outpatients><Parents><Participant><Parturition><Patient Self-Report><Pharmaceutical Preparations><Phenotype><Physiologic><Physiological><Prevalence><Proxy><Psychogalvanic Reflex><Psychologic Stress><Psychological Stress><Randomized><Reproducibility><Research><Research Design><Role><Scientist><Self Administered><Self Administration><Self-Report><Skin Electric Conductance><Spirituality><Statistical Methods><Stress><Stress Tests><Structure><Study Type><Task Performances><Testing><Training><Validation><acute stress><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence method><artificial intelligence powered><behavior measurement><behavioral measure><behavioral measurement><biological adaptation to stress><career><causation><cohort><computational modeling><computational models><computer based models><computerized modeling><craving><data integration><design><designing><developmental><disease causation><drug/agent><economic><enhanced with AI><enhanced with Artificial Intelligence><experience><flexibility><flexible><heart rate variability><improved><indexing><indicators of resilience><insight><kids><marker of biological resilience><markers underlying resilience><natural language understanding><novel><opiate consumption><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opioid consumption><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><parent><participant interview><perceived stress><perception of stress><phenotypic data><primary outcome><psychobiologic><psychobiological><psychologic><psychological><randomisation><randomization><randomly assigned><reactioncrisis><recruit><resilience><resilience biomarker><resilience marker><resilient><self-reported stress><signatures of resilience><skills><skin conductance><social role><statistic methods><stress perception><stress reactivity><stress response><stressreaction><study design><theories><timeline><translational impact><validations><youngster>

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Danielle Rebecca Fine

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$75,600

FY 2026

Project Title

Peer recovery support for people experiencing homelessness with opioid use disorder

Grant Number:

3K23DA058200-03S1

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY / ABSTRACT People experiencing homelessness (PEH) are disproportionately affected by the opioid overdose crisis, with overdose rates up to 30-times higher than the general population. Medications for opioid use disorder (OUD) substantially reduce mortality, but retention in treatment...

Research Terms

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Kevin Young Xu

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$75,600

FY 2026

Project Title

Using Big Data to Optimize Treatment of Opioid Use Disorder in Pregnancy

Grant Number:

3K08DA061258-02S1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY I am an early career investigator in the fields of pharmacoepidemiology, population health, and addiction psychiatry. My overarching career goal is to become an independently funded researcher dedicated to investigating the real- world effectiveness of addiction medications so that w...

Research Terms

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Devin Banks

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$75,584

FY 2026

Project Title

An Integrated Geospatial and Community-based Model to Prevent Opioid Overdose among Black Americans

Grant Number:

3K08DA058080-04S1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

“Opioid overdose death (OOD) rates among Black Americans have increased unabated since 2015, outpacing national averages at a rate of two to one. Health disparities in the growth rate of OOD have been documented in at least 23 states, including Missouri, which has second highest rate of OOD among Bl...

Research Terms

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Gail D'Onofrio

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 54/100

Large award

Recent

Active award

Team-scale grant

$13,368,428

FY 2026

Project Title

CTN New England Consortium Node

Grant Number:

5UG1DA015831-25

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2002

End Date:

2/29/2032

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

In this Administrative Supplement, the New England Consortium Node (NECN), led by Gail D’Onofrio MD, of Yale University, and Roger Weiss, MD, of McLean Hospital, is requesting support for approved, ongoing CTN studies including: CTN-0100 (RDD) Optimizing Retention, Duration, Discontinuation Strategi...

Research Terms

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Roger D. Weiss

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 54/100

Large award

Recent

Active award

Team-scale grant

$13,368,428

FY 2026

Project Title

CTN New England Consortium Node

Grant Number:

5UG1DA015831-25

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2002

End Date:

2/29/2032

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

In this Administrative Supplement, the New England Consortium Node (NECN), led by Gail D’Onofrio MD, of Yale University, and Roger Weiss, MD, of McLean Hospital, is requesting support for approved, ongoing CTN studies including: CTN-0100 (RDD) Optimizing Retention, Duration, Discontinuation Strategi...

Research Terms

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T John WINHUSEN

UNIVERSITY OF CINCINNATI, CINCINNATI, OH

Good lead · 54/100

Large award

Recent

Active award

Team-scale grant

$9,019,558

FY 2026

Project Title

The Ohio Valley Node of the Clinical Trials Network

Grant Number:

5UG1DA013732-27

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2000

End Date:

2/29/2032

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary (Abstract): This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions to the national opioid public health crisis. The NIH HEAL Initiative bolsters research across NIH to improve treatment for opioid misuse and addiction. Since...

Research Terms

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Niranjan Subhash Karnik

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 54/100

Large award

Recent

Active award

Team-scale grant

$4,155,569

FY 2026

Project Title

Great Lakes & Mid-Atlantic Node (GLMN) of the NIDA CTN

Grant Number:

5UG1DA049467-07

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/15/2019

End Date:

2/29/2032

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

In alignment with RFA-DA-25-027, this application seeks to renew the Great Lakes Node of the National Drug Abuse Treatment Clinical Trials Network (CTN) and expand its mission to serve a broader geographic reach. This expanded node will draw on an experienced set of investigators in the Greater Chic...

Research Terms

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ANTONIO A MORGAN-LOPEZ

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 54/100

Large award

Recent

Active award

Team-scale grant

$4,155,569

FY 2026

Project Title

Great Lakes & Mid-Atlantic Node (GLMN) of the NIDA CTN

Grant Number:

5UG1DA049467-07

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/15/2019

End Date:

2/29/2032

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

In alignment with RFA-DA-25-027, this application seeks to renew the Great Lakes Node of the National Drug Abuse Treatment Clinical Trials Network (CTN) and expand its mission to serve a broader geographic reach. This expanded node will draw on an experienced set of investigators in the Greater Chic...

Research Terms

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Richard S Schottenfeld

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 54/100

Large award

Recent

Active award

Team-scale grant

$4,155,569

FY 2026

Project Title

Great Lakes & Mid-Atlantic Node (GLMN) of the NIDA CTN

Grant Number:

5UG1DA049467-07

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/15/2019

End Date:

2/29/2032

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

In alignment with RFA-DA-25-027, this application seeks to renew the Great Lakes Node of the National Drug Abuse Treatment Clinical Trials Network (CTN) and expand its mission to serve a broader geographic reach. This expanded node will draw on an experienced set of investigators in the Greater Chic...

Research Terms

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Paul T Bremer

MCLEAN HOSPITAL, BELMONT, MA

Good lead · 54/100

Large award

Recent

Active award

Team-scale grant

$3,657,445

FY 2026

Project Title

Antibody-based therapy for fentanyl-related opioid use disorder

Grant Number:

4UH3DA058544-02

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2023

End Date:

1/31/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

Abstract. Abuse of synthetic opioids is a rapidly intensifying public health problem with more than 70,000 reported US overdose deaths in 2022. Currently available medications to reverse opioid intoxication include an intranasal formulation of the opioid antagonist naloxone, commonly known as Narcan...

Research Terms

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Rajeev Indrajit Desai

MCLEAN HOSPITAL, BELMONT, MA

Good lead · 54/100

Large award

Recent

Active award

Team-scale grant

$3,657,445

FY 2026

Project Title

Antibody-based therapy for fentanyl-related opioid use disorder

Grant Number:

4UH3DA058544-02

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2023

End Date:

1/31/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

Abstract. Abuse of synthetic opioids is a rapidly intensifying public health problem with more than 70,000 reported US overdose deaths in 2022. Currently available medications to reverse opioid intoxication include an intranasal formulation of the opioid antagonist naloxone, commonly known as Narcan...

Research Terms

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Rajesh A Patel

REACX PHARMACEUTICALS, INC., SOUTH SAN FRANCISCO, CA

Good lead · 54/100

Large award

Recent

Active award

Team-scale grant

$3,450,000

FY 2026

Project Title

Nalmefene Implant for the Long-Term Treatment of Opioid Use Disorder

Grant Number:

5UH3DA047707-04

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2018

End Date:

1/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary: Nalmefene Implant for the Long-Term Treatment of Opioid Use Disorder The U.S. currently faces a major crisis from the increasing number of deaths due to opioid overdose among Americans afflicted with the chronic medical condition called opioid use disorder (OUD). Harm from opioid mi...

Research Terms

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Irene Cortes-Puch

EICOSIS, LLC, Davis, CA

Good lead · 54/100

Large award

Recent

Active award

Team-scale grant

$2,377,268

FY 2026

Project Title

Development of a Soluble Epoxide Hydrolase Inhibitor to Spare or Replace Opioid Analgesics

Grant Number:

5UH3DA048767-05

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2019

End Date:

12/31/2026

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

Summary/Abstract EicOsis is developing a first-in-class analgesic with efficacy against neuropathic pain that will replace and dose spare opioids and thus prevent opioid use disorders (OUDs). The target of the small molecule inhibitor EC5026 is the soluble epoxide hydrolase, a master regulatory enzy...

Research Terms

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BRUCE D HAMMOCK

EICOSIS, LLC, Davis, CA

Good lead · 54/100

Large award

Recent

Active award

Team-scale grant

$2,377,268

FY 2026

Project Title

Development of a Soluble Epoxide Hydrolase Inhibitor to Spare or Replace Opioid Analgesics

Grant Number:

5UH3DA048767-05

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2019

End Date:

12/31/2026

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

Summary/Abstract EicOsis is developing a first-in-class analgesic with efficacy against neuropathic pain that will replace and dose spare opioids and thus prevent opioid use disorders (OUDs). The target of the small molecule inhibitor EC5026 is the soluble epoxide hydrolase, a master regulatory enzy...

Research Terms

View Full Project Details on NIH Reporter

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JAMIE PETERS

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Good lead · 52/100

Likely hiring

Solid budget

Active award

$475,771

FY 2026

Project Title

Prefrontal circuits controlling heroin seeking

Grant Number:

5R01DA061766-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Opioid use disorder (OUD) can be conceptualized as a two-sided coin, with one side of the pathology characterized by excessive motivational drive for opioids, and on the other side, a weakened ability to suppress opioid-seeking impulses. As the seat of executive function, the prefron...

Research Terms

View Full Project Details on NIH Reporter

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Joao Paulo De Aquino

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 52/100

Likely hiring

Solid budget

Active award

$454,523

FY 2026

Project Title

Combination of THC and CBD as a Novel Treatment for Co-Occurring Opioid Addiction and Chronic Pain

Grant Number:

5R01DA060066-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/28/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT This application aims to examine the combined analgesic and anti-craving effects of delta-9- tetrahydrocannabinol (THC) and cannabidiol (CBD) in individuals with co-occurring opioid use disorder (OUD) and chronic pain undergoing opioid agonist therapy. Chronic pain affects ...

Research Terms

<9-ene-Tetrahydrocannabinol><Adanon><Address><Adverse effects><Affect><Althose><Analgesia Tests><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Behavior><Benchmarking><Benefits and Risks><Best Practice Analysis><Blood><Blood Plasma><Blood Reticuloendothelial System><CB1><CB1 Receptor><CB1R><CNR1 gene><CNS Nervous System><Cannabidiol><Cannabinoid Receptor CB1><Cannabinoids><Cannabis><Cell Communication and Signaling><Cell Signaling><Central Nervous System><Chronic><Chronic low back pain><Clinical><Cognitive><Cues><D9-tetrahydrocannabinol><DSM-5><DSM-V><DSM5><Delta-9-Tetrahydrocannabinol><Diacetylmorphine><Diagnostic and Statistical Manual of Mental Disorders, 5th edition><Diagnostic and Statistical Manual of Mental Disorders-V><Diamorphine><Dolophine><Dose><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Drug Interactions><Drugs><Enrollment><Health Care Professional><Health Priorities><Health Professional><Heroin><Human><Hyperalgesia><Hyperalgesic Sensations><Individual><Intracellular Communication and Signaling><Investigators><Knowledge><Laboratory Study><Lead><Link><Low Back Ache><Low Back Pain><Low Backache><Lumbago><Maintenance><Measures><Medication><Medicine><Methadone><Methadose><Modeling><Modern Man><Morbidity><NIH><National Institutes of Health><Neuraxis><Nociception><Nociception Tests><Opiate Addiction><Opiate Dependence><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid agonist><Opioid receptor agonist><Oral><Outcome><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Therapy><Pain management><Pain measure><Painful><Participant><Patients><Pb element><Persons><Pharmaceutical Preparations><Placebo Control><Placebos><Plasma><Plasma Serum><Policies><Population><Population Research><Population-based research><Population-level research><Process><Property><Psychomotor Impairments><Psychomotor Performance><Qualifying><Randomized><Relapse><Research><Research Personnel><Researchers><Reticuloendothelial System, Serum, Plasma><Sensory><Sham Treatment><Signal Transduction><Signal Transduction Systems><Signaling><Testing><Tetrahydrocannabinol><Therapeutic Effect><Treatment outcome><United States National Institutes of Health><Visual><Vulnerable Populations><Woman><abuse liability><abuse potential><addiction><addictive disorder><benchmark><biological signal transduction><cannabinoid receptor 1><cannabinoid receptor type 1><cannabinoid type 1><central sensitization><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><craving><delta(1)-THC><delta(1)-Tetrahydrocannabinol><delta(9)-THC><delta(9)-Tetrahydrocannabinol><design><designing><drug development><drug reinforcement><drug/agent><eCB system><effective therapy><effective treatment><endocannabinoid system><endogenous cannabinoid system><enroll><experience><heavy metal Pb><heavy metal lead><hyperalgia><indexing><insight><investigate population><men><model development><model developments><mortality><multi-modality><multimodality><neglect><neural adaptation><neuroadaptation><neuronal excitability><neuroprotection><neuroprotective><neurotransmitter release><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><nociceptive><non-medical opioid use><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonmedical opioid use><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><opiate crisis><opiate misuse><opiate therapy><opiate use disorder><opioid addiction><opioid agonist therapy><opioid agonist treatment><opioid crisis><opioid dependence><opioid dependent><opioid epidemic><opioid misuse><opioid therapy><opioid use disorder><pain assay><pain intervention><pain killer><pain medication><pain relief><pain reliever><pain sensitivity><pain signal><pain treatment><painkiller><performance tests><placebo controlled><population investigation><population level investigation><population specific research><psychomotor function><randomisation><randomization><randomly assigned><relieve pain><response><sex><sham therapy><studies of populations><study of the population><study population><survey population><treat chronic pain><vulnerable group><vulnerable individual><vulnerable people><Δ(1)-THC><Δ(1)-tetrahydrocannabinol><Δ(9)-THC><Δ(9)-tetrahydrocannabinol><Δ-9-tetrahydrocannabinol><Δ9-tetrahydrocannabinol>

View Full Project Details on NIH Reporter

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Xiaoke Chen

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$448,186

FY 2026

Project Title

Circuitry and Molecular Mechanisms for Descending Pain Facilitation

Grant Number:

5R01NS129834-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract Chronic pain is a pervasive global health issue affecting about 20% of individuals worldwide, but available treatments for chronic pain are still inadequate. Opiates have been used for centuries as potent analgesics, but issues with tolerance, abuse, and overdose have contributed to current...

Research Terms

<21+ years old><Adeno-Associated Viruses><Adult><Adult Human><Affect><American><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Anterior Quadrigeminal Body><Antinociceptive Agents><Antinociceptive Drugs><Automobile Driving><Brain><Brain Nervous System><Brain Stem><Brainstem><CRE Recombinase><Calcium><Cell Body><Cell Nucleus><Cells><Chronic><Classification><Cognitive><Dependoparvovirus><Dependovirus><Development><Encephalon><Enterobacteria phage P1 Cre recombinase><Genes><Genetic><Individual><Infumorph><Infusion><Infusion procedures><Injury><KI mice><Kadian><Knock-in Mouse><Lateral><Long-term pain><MS Contin><MSir><Maintenance><Mechanics><Medulla Spinalis><Mice><Mice Mammals><Molecular><Moods><Morphia><Morphine><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Pathways><Neurocyte><Neurons><Neuropeptides><Nociception><Nociceptive Impulse><Nociceptive Stimulus><Nucleus><Opiate Receptors><Opiates><Opioid><Opioid Receptor><Optic Tectum><Oramorph><Oramorph SR><Overdose><Pain><Painful><Pathway interactions><Persistent pain><Play><Rabies lyssavirus><Rabies mapping><Rabies trans synaptic tracing><Rabies virus><Rabies virus mediated mapping><Receptor Protein><RiboTag><Role><Roxanol><Spinal Cord><Statex SR><Superior Colliculus><Systematics><Testing><Therapeutic><Transmission><Viral><adeno associated virus group><adulthood><bacteriophage P1 recombinase Cre><cellular targeting><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><constant pain><developmental><driving><experiment><experimental research><experimental study><experiments><global health><infusions><injuries><injury to tissue><interest><knock-down><knockdown><knockin mice><lasting pain><mechanic><mechanical><mechanical allodynia><mechanical drive><mutant><nerve injury><neural injury><neuronal><neuropathic pain><nociceptive><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><on-going pain><ongoing pain><opiate crisis><opioid crisis><opioid epidemic><pain killer><pain medication><pain reliever><painful neuropathy><painkiller><pathway><prevent><preventing><rabies based mapping><rabies based retrograde mapping><rabies circuit tracing><rabies mediated retrograde monosynaptic tracing><rabies retrograde tracing><rabies tracer><rabies tracing><rabies viral tracing><rabies virus mediated circuit mapping><rabies virus monosynaptic circuit tracing><rabies virus monosynaptic tracing><rabies virus neurotracer><rabies virus retrograde tracing><rabies virus tracing><receptor><recruit><response><social role><spared nerve><superior colliculus Corpora quadrigemina><tissue injury><tool><tracing with rabies><transmission process><treat chronic pain><visual tectum>

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THOMAS JEFFREY MARTIN

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Good lead · 52/100

Likely hiring

Solid budget

Active award

$437,935

FY 2026

Project Title

Cell-directed gene therapy for pain recovery after surgery and inflammation

Grant Number:

5R01NS122153-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Summary We have recently discovered macrophage ED2/CD163 gene overexpression as a novel and safe pain therapeutic target in the local peripheral immune system in a major surgery rat model. We propose to develop a cell-directed gene therapy that would correct the underlying local immunological cause ...

Research Terms

<(TNF)-α><3-D><3-Dimensional><3D><Acute Pain><Acutely painful><Address><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Arthritis><Assay><Attention><Behavior><Behavior assessment><Behavioral><Beta Proprotein Interleukin 1><Bioassay><Bioinformatics><Biological Assay><Body Tissues><Cachectin><Cell Body><Cell Communication and Signaling><Cell Reprogramming><Cell Signaling><Cells><Chronic><Chronic inflammatory pain><Clinical><Common Rat Strains><Complementary DNA><Complex><Critical Paths><Critical Pathways><Data><Development><Dimensions><Disease Progression><Dose><Dose Limiting><Drug abuse><Drugs><Freund's Adjuvant><Freund's Complete Adjuvant><Gene Expression><Gene Transcription><Genes><Genetic Transcription><Human><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><Immune response><Immune system><Immunobiology><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Immunophysiology><Infiltration><Inflammation><Inflammation Mediators><Inflammatory><Infumorph><Injury><Interleukin 1beta><Interleukin-1 beta><Interleukin-1β><Intervention><Intracellular Communication and Signaling><Kadian><Knee><Light><Link><Load Bearing><MS Contin><MSir><Macrophage><Macrophage-Derived TNF><Measures><Mechanics><Mediator><Medication><Modeling><Modern Man><Molecular><Monocyte-Derived TNF><Morphia><Morphine><Muscle><Muscle Tissue><Mφ><Nanotechnology><Nucleic Acids><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Oramorph><Oramorph SR><Otomy><Outcome><Pain><Pain Control><Pain Therapy><Pain management><Painful><Patients><Peripheral><Pharmaceutical Preparations><Phenotype><Photoradiation><Plasmids><Polyaziridine><Polyethyleneimine><Position><Positioning Attribute><Post-operative Pain><Postoperative Pain><Preinterleukin 1 Beta><Process><Production><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Rat><Rats Mammals><Rattus><Recovery><Recovery of Function><Research><Resolution><Roxanol><Short interfering RNA><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Skin Tissue><Speed><Statex SR><Surgical><Surgical Interventions><Surgical Models><Surgical Procedure><Surgical incisions><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Technology><Testing><Therapeutic><Tissues><Transcription><Trauma><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Weight Bearing><Weight-Bearing state><Wound Repair><abuse of drugs><abuses drugs><addiction><addictive disorder><arthritic><behavioral assessment><biological signal transduction><cDNA><cellular reprogramming><chronic and inflammatory pain><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><clinical relevance><clinically relevant><cutaneous tissue><cytokine><design><designing><developmental><drug/agent><functional recovery><gain of function><gene induction><gene signatures><gene-based treatment><gene-directed therapy><gene-targeted therapy><gene-targeted treatment><genetic signature><genome scale><genome-wide><genomewide><high risk><homopolymer Aziridine><host response><human data><immune system response><immunoresponse><improved><incision><induction of genes><inflammatory mediator><inflammatory pain><injured><injuries><innovate><innovation><innovative><insight><knock-down><knockdown><loss of function><mechanic><mechanical><multidisciplinary><muscular><nano particle><nano tech><nano technology><nano-sized particle><nano-technological><nanoparticle><nanosized particle><nanotech><nanotechnological><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><opiate abuse><opiate crisis><opiate drug abuse><opioid abuse><opioid crisis><opioid drug abuse><opioid epidemic><opioid sparing><overexpress><overexpression><pain after surgery><pain behavior><pain intervention><pain model><pain reduction><pain treatment><post-surgical pain><postoperative recovery><postsurgical pain><prevent><preventing><programs><recovery after surgery><recovery following surgery><reduce pain><resolutions><response><scRNA sequencing><scRNA-seq><siRNA><side effect><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><surgery><surgery pain><surgical pain><therapeutic target><three dimensional><tissue repair><tissue wound><tool><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translational opportunities><translational potential><treat chronic pain><wound><wound healing><wound recovery><wound resolution><wounding><wounds>

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E. Alfonso Romero-Sandoval

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Good lead · 52/100

Likely hiring

Solid budget

Active award

$437,935

FY 2026

Project Title

Cell-directed gene therapy for pain recovery after surgery and inflammation

Grant Number:

5R01NS122153-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Summary We have recently discovered macrophage ED2/CD163 gene overexpression as a novel and safe pain therapeutic target in the local peripheral immune system in a major surgery rat model. We propose to develop a cell-directed gene therapy that would correct the underlying local immunological cause ...

Research Terms

<(TNF)-α><3-D><3-Dimensional><3D><Acute Pain><Acutely painful><Address><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Arthritis><Assay><Attention><Behavior><Behavior assessment><Behavioral><Beta Proprotein Interleukin 1><Bioassay><Bioinformatics><Biological Assay><Body Tissues><Cachectin><Cell Body><Cell Communication and Signaling><Cell Reprogramming><Cell Signaling><Cells><Chronic><Chronic inflammatory pain><Clinical><Common Rat Strains><Complementary DNA><Complex><Critical Paths><Critical Pathways><Data><Development><Dimensions><Disease Progression><Dose><Dose Limiting><Drug abuse><Drugs><Freund's Adjuvant><Freund's Complete Adjuvant><Gene Expression><Gene Transcription><Genes><Genetic Transcription><Human><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><Immune response><Immune system><Immunobiology><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Immunophysiology><Infiltration><Inflammation><Inflammation Mediators><Inflammatory><Infumorph><Injury><Interleukin 1beta><Interleukin-1 beta><Interleukin-1β><Intervention><Intracellular Communication and Signaling><Kadian><Knee><Light><Link><Load Bearing><MS Contin><MSir><Macrophage><Macrophage-Derived TNF><Measures><Mechanics><Mediator><Medication><Modeling><Modern Man><Molecular><Monocyte-Derived TNF><Morphia><Morphine><Muscle><Muscle Tissue><Mφ><Nanotechnology><Nucleic Acids><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Oramorph><Oramorph SR><Otomy><Outcome><Pain><Pain Control><Pain Therapy><Pain management><Painful><Patients><Peripheral><Pharmaceutical Preparations><Phenotype><Photoradiation><Plasmids><Polyaziridine><Polyethyleneimine><Position><Positioning Attribute><Post-operative Pain><Postoperative Pain><Preinterleukin 1 Beta><Process><Production><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Rat><Rats Mammals><Rattus><Recovery><Recovery of Function><Research><Resolution><Roxanol><Short interfering RNA><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Skin Tissue><Speed><Statex SR><Surgical><Surgical Interventions><Surgical Models><Surgical Procedure><Surgical incisions><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Technology><Testing><Therapeutic><Tissues><Transcription><Trauma><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Weight Bearing><Weight-Bearing state><Wound Repair><abuse of drugs><abuses drugs><addiction><addictive disorder><arthritic><behavioral assessment><biological signal transduction><cDNA><cellular reprogramming><chronic and inflammatory pain><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><clinical relevance><clinically relevant><cutaneous tissue><cytokine><design><designing><developmental><drug/agent><functional recovery><gain of function><gene induction><gene signatures><gene-based treatment><gene-directed therapy><gene-targeted therapy><gene-targeted treatment><genetic signature><genome scale><genome-wide><genomewide><high risk><homopolymer Aziridine><host response><human data><immune system response><immunoresponse><improved><incision><induction of genes><inflammatory mediator><inflammatory pain><injured><injuries><innovate><innovation><innovative><insight><knock-down><knockdown><loss of function><mechanic><mechanical><multidisciplinary><muscular><nano particle><nano tech><nano technology><nano-sized particle><nano-technological><nanoparticle><nanosized particle><nanotech><nanotechnological><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><opiate abuse><opiate crisis><opiate drug abuse><opioid abuse><opioid crisis><opioid drug abuse><opioid epidemic><opioid sparing><overexpress><overexpression><pain after surgery><pain behavior><pain intervention><pain model><pain reduction><pain treatment><post-surgical pain><postoperative recovery><postsurgical pain><prevent><preventing><programs><recovery after surgery><recovery following surgery><reduce pain><resolutions><response><scRNA sequencing><scRNA-seq><siRNA><side effect><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><surgery><surgery pain><surgical pain><therapeutic target><three dimensional><tissue repair><tissue wound><tool><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translational opportunities><translational potential><treat chronic pain><wound><wound healing><wound recovery><wound resolution><wounding><wounds>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Stephen Vincent Mahler

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$353,250

FY 2026

Project Title

Ventral Pallidum Circuits Underlying Preclinical Models of Opioid Addiction

Grant Number:

5R01DA055849-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Addiction, and opioid use disorder (OUD) in particular, is a scourge on American life. Though we know much from animal models about how opioid drugs act on the brain, we have yet to develop new OUD treatments based on this knowledge. Why is this? Our lab, like others in recent years...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><Abstinence><American><Aminalon><Aminalone><Animal Model><Animal Models and Related Studies><Animals><Appetite><Attention><Behavior><Behavior Disorders><Behavioral><Brain><Brain Nervous System><Chronic><Circulatory Collapse><Common Rat Strains><Cues><Dangerousness><Darkness><Data><Desire for food><Diacetylmorphine><Diamorphine><Disease><Disorder><Drug usage><Drugs><Economics><Elasticity><Encephalon><Essential Drugs><Failure><GABA><Genetic><Globus Pallidus><Habenula><Half-Life><Heroin><Human><Individual><Intervention><Jobs><Knowledge><Lateral><Learning><Life><Measures><Mediating><Medication><Modeling><Modern Man><Motivation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurosciences><Occupations><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Output><Pathway interactions><Performance><Pharmaceutical Preparations><Play><Position><Positioning Attribute><Pre-Clinical Model><Preclinical Models><Process><Professional Positions><Psychological reinforcement><Punishment><Rat><Rat Transgene><Rats Mammals><Rattus><Reinforcement><Relapse><Rewards><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><Scourge><Shock><Side><Symptoms><Testing><Ventral Tegmental Area><Withdrawal><Withdrawal Symptom><addiction><addictive disorder><behavioral disorder><circulatory shock><cocaine relapse><drug action><drug use><drug/agent><economic><experience><fentalogs><fentalogues><fentanyl analog><gamma-Aminobutyric Acid><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><hedonic><heroin intake><heroin use><model of animal><motivated behavior><neural network><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><opiate crisis><opiate use disorder><opioid addiction><opioid crisis><opioid dependence><opioid dependent><opioid epidemic><opioid use disorder><pallidum><pathway><pre-clinical study><preclinical study><relapse against cocaine><remifentanil><segregation><shocks><social role><stem><tool><treatment strategy><ventral tegmentum><γ-Aminobutyric Acid>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Douglas Oyler

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Good lead · 48/100

Large award

Active award

Team-scale grant

$1,096,918

FY 2026

Project Title

Empowering dentists to reduce opioid prescriptions to young people

Grant Number:

5UH3DE032621-04

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Dentists are the leading prescriber of opioids to adolescents and young adults (AYAs), even though opioid use after tooth extraction is not associated with improved pain control or satisfaction. In AYAs, an opioid prescription after a dental procedure increases the risk of opioid misuse, us...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Marcia Vanessa Rojas Ramirez

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Good lead · 48/100

Large award

Active award

Team-scale grant

$1,096,918

FY 2026

Project Title

Empowering dentists to reduce opioid prescriptions to young people

Grant Number:

5UH3DE032621-04

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2028

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Dentists are the leading prescriber of opioids to adolescents and young adults (AYAs), even though opioid use after tooth extraction is not associated with improved pain control or satisfaction. In AYAs, an opioid prescription after a dental procedure increases the risk of opioid misuse, us...

Research Terms

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Ingrid A Binswanger

KAISER FOUNDATION RESEARCH INSTITUTE, Oakland, CA

Good lead · 48/100

Above-average budget

Recent

Active award

Team-scale grant

$993,689

FY 2026

Project Title

Health Systems Node of the NIDA Clinical Trials Network

Grant Number:

5UG1DA040314-12

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2015

End Date:

2/29/2032

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

Substance use (SU) and substance use disorders (SUDs) are among the greatest causes of chronic illness and death in the United States. High potency synthetic opioid (i.e., fentanyl) and stimulant use has contributed to a national overdose crisis. In addition, polysubstance use is increasing, complic...

Research Terms

<21+ years old><Actiq><Address><Adolescent and Young Adult><Adult><Adult Human><Adverse effects><Buprenorphine><Cannabis><Care Manager><Care given by nurses><Caring><Case Manager><Cessation of life><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Research><Clinical Study><Clinical Treatment><Clinical Trials Network><Community Health Care><DSM-5><DSM-V><DSM5><Data><Death><Diagnostic and Statistical Manual of Mental Disorders, 5th edition><Diagnostic and Statistical Manual of Mental Disorders-V><Drug abuse><Duragesic><Electronic Health Record><Family><Fentanest><Fentanyl><Fentyl><Future><Health><Health Care Systems><Health system><Hospitals><Individual><Intervention><Investigators><Lead><Link><Measurement><Measures><Medical><Methodology><Methods><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Nursing Care><Outcome><Outcome Measure><Overdose><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Persons><Phentanyl><Play><Population><Population Intervention><Population Research><Population Study><Population-based research><Population-level research><Position><Positioning Attribute><Prevention><Primary Care><Primary Nursing Care><Public Health><QOC><Qualitative Methods><Quality of Care><Recovery><Reporting><Research><Research Personnel><Researchers><Risk><Role><Rural><Safety><Site><Statistical Methods><Stimulant><Substance Use Disorder><Survey Instrument><Surveys><Symptoms><System><THC co-use><THC use><Testing><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Time><Treatment outcome><United States><Veterans Health Administration><Veterans Health Affairs><World Health><Youth><Youth 10-21><abuse of drugs><abuses drugs><adulthood><adverse consequence><adverse outcome><buprenorphine treatment><cannabis use><cannabis use disorder><chronic disorder><clinical care><clinical intervention><clinical therapy><community care><design><designing><digital therapeutics><digital therapy><digital treatment><disease prevention><disorder prevention><effective therapy><effective treatment><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><health care settings><heavy metal Pb><heavy metal lead><implementation trial><improved><improved outcome><innovate><innovation><innovative><intervention design><investigate population><licit opioid><life span><lifespan><long-term recovery><marijuana use><marijuana use and disorder><marijuana use disorder><measurable outcome><mortality><multi-site trial><multiple substance use><multisite trial><multisubstance use><neglect><novel><old age><opiate medication><opiate overdose><opiate related overdose><opiate use disorder><opioid drug overdose><opioid induced overdose><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use disorder><outcome measurement><overdose death><overdose fatalities><overdose prevention><participant engagement><patient engagement><patient oriented outcomes><poly substance use><polysubstance use><population based><population based intervention><population investigation><population level investigation><population research study><population specific intervention><population specific research><population survey><population-based study><population-level study><practical implementation><pragmatic effectiveness trial><pragmatic implementation><pragmatic trial><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent><preventing><primary care team><psychostimulant use><qualitative reasoning><satisfaction><social role><statistic methods><stimulant use><studies of populations><study of the population><study population><substance use><substance use and disorder><substance use treatment><substance using><success><survey population><synthetic opiate><synthetic opioid><systems research><therapy design><treatment design><trial design><trial regimen><trial treatment><use of stimulants><virtual therapy><virtual treatment><youth age>

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Katharine Anthony Bradley

KAISER FOUNDATION RESEARCH INSTITUTE, Oakland, CA

Good lead · 48/100

Above-average budget

Recent

Active award

Team-scale grant

$993,689

FY 2026

Project Title

Health Systems Node of the NIDA Clinical Trials Network

Grant Number:

5UG1DA040314-12

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2015

End Date:

2/29/2032

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

Substance use (SU) and substance use disorders (SUDs) are among the greatest causes of chronic illness and death in the United States. High potency synthetic opioid (i.e., fentanyl) and stimulant use has contributed to a national overdose crisis. In addition, polysubstance use is increasing, complic...

Research Terms

<21+ years old><Actiq><Address><Adolescent and Young Adult><Adult><Adult Human><Adverse effects><Buprenorphine><Cannabis><Care Manager><Care given by nurses><Caring><Case Manager><Cessation of life><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Research><Clinical Study><Clinical Treatment><Clinical Trials Network><Community Health Care><DSM-5><DSM-V><DSM5><Data><Death><Diagnostic and Statistical Manual of Mental Disorders, 5th edition><Diagnostic and Statistical Manual of Mental Disorders-V><Drug abuse><Duragesic><Electronic Health Record><Family><Fentanest><Fentanyl><Fentyl><Future><Health><Health Care Systems><Health system><Hospitals><Individual><Intervention><Investigators><Lead><Link><Measurement><Measures><Medical><Methodology><Methods><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Nursing Care><Outcome><Outcome Measure><Overdose><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Persons><Phentanyl><Play><Population><Population Intervention><Population Research><Population Study><Population-based research><Population-level research><Position><Positioning Attribute><Prevention><Primary Care><Primary Nursing Care><Public Health><QOC><Qualitative Methods><Quality of Care><Recovery><Reporting><Research><Research Personnel><Researchers><Risk><Role><Rural><Safety><Site><Statistical Methods><Stimulant><Substance Use Disorder><Survey Instrument><Surveys><Symptoms><System><THC co-use><THC use><Testing><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Time><Treatment outcome><United States><Veterans Health Administration><Veterans Health Affairs><World Health><Youth><Youth 10-21><abuse of drugs><abuses drugs><adulthood><adverse consequence><adverse outcome><buprenorphine treatment><cannabis use><cannabis use disorder><chronic disorder><clinical care><clinical intervention><clinical therapy><community care><design><designing><digital therapeutics><digital therapy><digital treatment><disease prevention><disorder prevention><effective therapy><effective treatment><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><health care settings><heavy metal Pb><heavy metal lead><implementation trial><improved><improved outcome><innovate><innovation><innovative><intervention design><investigate population><licit opioid><life span><lifespan><long-term recovery><marijuana use><marijuana use and disorder><marijuana use disorder><measurable outcome><mortality><multi-site trial><multiple substance use><multisite trial><multisubstance use><neglect><novel><old age><opiate medication><opiate overdose><opiate related overdose><opiate use disorder><opioid drug overdose><opioid induced overdose><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use disorder><outcome measurement><overdose death><overdose fatalities><overdose prevention><participant engagement><patient engagement><patient oriented outcomes><poly substance use><polysubstance use><population based><population based intervention><population investigation><population level investigation><population research study><population specific intervention><population specific research><population survey><population-based study><population-level study><practical implementation><pragmatic effectiveness trial><pragmatic implementation><pragmatic trial><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent><preventing><primary care team><psychostimulant use><qualitative reasoning><satisfaction><social role><statistic methods><stimulant use><studies of populations><study of the population><study population><substance use><substance use and disorder><substance use treatment><substance using><success><survey population><synthetic opiate><synthetic opioid><systems research><therapy design><treatment design><trial design><trial regimen><trial treatment><use of stimulants><virtual therapy><virtual treatment><youth age>

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CYNTHIA I CAMPBELL

KAISER FOUNDATION RESEARCH INSTITUTE, Oakland, CA

Good lead · 48/100

Above-average budget

Recent

Active award

Team-scale grant

$993,689

FY 2026

Project Title

Health Systems Node of the NIDA Clinical Trials Network

Grant Number:

5UG1DA040314-12

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2015

End Date:

2/29/2032

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

Substance use (SU) and substance use disorders (SUDs) are among the greatest causes of chronic illness and death in the United States. High potency synthetic opioid (i.e., fentanyl) and stimulant use has contributed to a national overdose crisis. In addition, polysubstance use is increasing, complic...

Research Terms

<21+ years old><Actiq><Address><Adolescent and Young Adult><Adult><Adult Human><Adverse effects><Buprenorphine><Cannabis><Care Manager><Care given by nurses><Caring><Case Manager><Cessation of life><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Research><Clinical Study><Clinical Treatment><Clinical Trials Network><Community Health Care><DSM-5><DSM-V><DSM5><Data><Death><Diagnostic and Statistical Manual of Mental Disorders, 5th edition><Diagnostic and Statistical Manual of Mental Disorders-V><Drug abuse><Duragesic><Electronic Health Record><Family><Fentanest><Fentanyl><Fentyl><Future><Health><Health Care Systems><Health system><Hospitals><Individual><Intervention><Investigators><Lead><Link><Measurement><Measures><Medical><Methodology><Methods><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Nursing Care><Outcome><Outcome Measure><Overdose><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Persons><Phentanyl><Play><Population><Population Intervention><Population Research><Population Study><Population-based research><Population-level research><Position><Positioning Attribute><Prevention><Primary Care><Primary Nursing Care><Public Health><QOC><Qualitative Methods><Quality of Care><Recovery><Reporting><Research><Research Personnel><Researchers><Risk><Role><Rural><Safety><Site><Statistical Methods><Stimulant><Substance Use Disorder><Survey Instrument><Surveys><Symptoms><System><THC co-use><THC use><Testing><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Time><Treatment outcome><United States><Veterans Health Administration><Veterans Health Affairs><World Health><Youth><Youth 10-21><abuse of drugs><abuses drugs><adulthood><adverse consequence><adverse outcome><buprenorphine treatment><cannabis use><cannabis use disorder><chronic disorder><clinical care><clinical intervention><clinical therapy><community care><design><designing><digital therapeutics><digital therapy><digital treatment><disease prevention><disorder prevention><effective therapy><effective treatment><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><health care settings><heavy metal Pb><heavy metal lead><implementation trial><improved><improved outcome><innovate><innovation><innovative><intervention design><investigate population><licit opioid><life span><lifespan><long-term recovery><marijuana use><marijuana use and disorder><marijuana use disorder><measurable outcome><mortality><multi-site trial><multiple substance use><multisite trial><multisubstance use><neglect><novel><old age><opiate medication><opiate overdose><opiate related overdose><opiate use disorder><opioid drug overdose><opioid induced overdose><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use disorder><outcome measurement><overdose death><overdose fatalities><overdose prevention><participant engagement><patient engagement><patient oriented outcomes><poly substance use><polysubstance use><population based><population based intervention><population investigation><population level investigation><population research study><population specific intervention><population specific research><population survey><population-based study><population-level study><practical implementation><pragmatic effectiveness trial><pragmatic implementation><pragmatic trial><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent><preventing><primary care team><psychostimulant use><qualitative reasoning><satisfaction><social role><statistic methods><stimulant use><studies of populations><study of the population><study population><substance use><substance use and disorder><substance use treatment><substance using><success><survey population><synthetic opiate><synthetic opioid><systems research><therapy design><treatment design><trial design><trial regimen><trial treatment><use of stimulants><virtual therapy><virtual treatment><youth age>

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Katie L Walsh

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 48/100

Above-average budget

Very recent

Active award

$862,550

FY 2026

Project Title

"Testing a Video and Text Messaging Intervention to reduce PTSD and Opioid Misuse Among Sexual Violence Survivors"

Grant Number:

4R33DA059897-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2023

End Date:

3/31/2030

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Responding to NIH’s Helping to End Addiction Long-term (HEAL) initiative NOSI titled “Opioid Use Disorder Care Pathways for Individuals with Histories of Exposure to Violence,” this R61/R33 project seeks to develop and evaluate a brief video and text messaging intervention delivered in the emergency...

Research Terms

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Gerald T. Cochran

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 48/100

Above-average budget

Recent

Active award

Team-scale grant

$777,392

FY 2026

Project Title

Greater Intermountain Node

Grant Number:

5UG1DA049444-07

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2019

End Date:

2/29/2032

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

In 2019, the University of Utah’s (UU) Greater Intermountain Node (GIN) expanded the existing NIH NIDA Clinical Trial Network’s (CTN) infrastructure by developing and testing innovative approaches for preventing, intervening, and treating opioid use disorder (OUD); preventing overdose; expanding set...

Research Terms

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Adam Joseph Gordon

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 48/100

Above-average budget

Recent

Active award

Team-scale grant

$777,392

FY 2026

Project Title

Greater Intermountain Node

Grant Number:

5UG1DA049444-07

Activity Code:

UG1

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2019

End Date:

2/29/2032

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

In 2019, the University of Utah’s (UU) Greater Intermountain Node (GIN) expanded the existing NIH NIDA Clinical Trial Network’s (CTN) infrastructure by developing and testing innovative approaches for preventing, intervening, and treating opioid use disorder (OUD); preventing overdose; expanding set...

Research Terms

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James Glenn Stevenson

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 48/100

Above-average budget

Very recent

Active award

$557,105

FY 2026

Project Title

Public Access Naloxone Design, Dissemination and Assessment (PANDDA)

Grant Number:

1R61DA062333-01A1

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract: The opioid overdose epidemic continues to impose a significant burden on society, with the CDC reporting over 60,000 opioid-related overdose deaths in the United States in the 12 months ending September 2024. While existing strategies have helped reduce fatalities, overdose...

Research Terms

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Scott Gordon Weiner

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 48/100

Above-average budget

Very recent

Active award

$557,105

FY 2026

Project Title

Public Access Naloxone Design, Dissemination and Assessment (PANDDA)

Grant Number:

1R61DA062333-01A1

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract: The opioid overdose epidemic continues to impose a significant burden on society, with the CDC reporting over 60,000 opioid-related overdose deaths in the United States in the 12 months ending September 2024. While existing strategies have helped reduce fatalities, overdose...

Research Terms

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Francesca Beaudoin

BROWN UNIVERSITY, PROVIDENCE, RI

Good lead · 48/100

Above-average budget

Recent

Active award

Team-scale grant

$508,750

FY 2026

Project Title

Identifying optimal buprenorphine dosing for OUD treatment and prevention of overdose

Grant Number:

5UH3DA056880-03

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT Synthetic opioids including fentanyl and its analogs have flooded the unregulated drug market in the United States and are responsible for nearly three quarters of the nation’s fatal drug overdoses. Concurrently increased challenges of buprenorphine initiation and maintenance treatm...

Research Terms

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Rachel Wightman

BROWN UNIVERSITY, PROVIDENCE, RI

Good lead · 48/100

Above-average budget

Recent

Active award

Team-scale grant

$508,750

FY 2026

Project Title

Identifying optimal buprenorphine dosing for OUD treatment and prevention of overdose

Grant Number:

5UH3DA056880-03

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT Synthetic opioids including fentanyl and its analogs have flooded the unregulated drug market in the United States and are responsible for nearly three quarters of the nation’s fatal drug overdoses. Concurrently increased challenges of buprenorphine initiation and maintenance treatm...

Research Terms

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Michele J Buonora

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$199,584

FY 2026

Project Title

Patient-controlled analgesia for acute pain among hospitalized people with opioid use disorder: A hybrid effectiveness-implementation study

Grant Number:

1K23DA062752-01A1

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Dr. Michele Buonora proposes a five-year mentored research and career development plan that will establish her as an independent clinician investigator using implementation science to develop, test, and disseminate interventions to improve outcomes for people with opioid use disorder (POUD) and pain...

Research Terms

<21+ years old><Academy><Acute Pain><Acute pain management><Acutely painful><Address><Admission><Admission activity><Adoption><Adult><Adult Human><Antibiotic Therapy><Antibiotic Treatment><Bolus><Bolus Infusion><Care Givers><Caregivers><Caring><Client satisfaction><Clinical><Clinical Trials><Communities><Conduct Clinical Trials><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Data><Development Plans><Development and Research><Devices><Dihydrohydroxycodeinone><Dihydromorphinone><Dilaudid><Dilaudid HP><Dimorphone><Dose><Effectiveness><Evidence based intervention><Family><Future><General Population><General Public><Goals><Hospital Administration><Hospital Admission><Hospital Management><Hospitalization><Hospitals><Hybrids><Hydromorphon><Hydromorphone><Hydrostat><Hymorphan><Hyperalgesia><Hyperalgesic Sensations><Incidence><Infection><Injections><Intervention><Intervention Studies><Interview><Intravenous><Investigators><Laudacon><Laudicon><Lead><Leadership><Lived experience><Lived experiences><Mediating><Medical><Medicine><Mentors><Methods><Novolauden><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid agonist><Opioid receptor agonist><Outcome><Overdose><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Pain><Pain Control><Pain Therapy><Pain intensity><Pain management><Painful><Patient Satisfaction><Patient outcome><Patient-Centered Outcomes><Patient-Controlled Analgesia><Patient-Focused Outcomes><Patients><Pb element><Persons><Proctor evaluation model><Proctor framework><Proctor multi-level outcomes framework><Proctor multilevel outcomes framework><Proctor process outcomes><Proctor taxonomy><Protocol><Protocols documentation><Qualitative Methods><R & D><R&D><Randomized><Receptor Protein><Research><Research Personnel><Researchers><Respiratory Depression><Risk><Roxicodone><Safety><Sedation procedure><Self Direction><Self Efficacy><Structure><Study models><System><Teaching Hospitals><Testing><Time><Training><Traumatic injury><Ventilatory Depression><Withdrawal><Work><adulthood><adverse event risk><assess effectiveness><awake><bacterial disease treatment><bacterial infectious disease treatment><care as usual><career development><clinical care><community engaged participatory research><community engaged research><community partnered research><community-engaged study><community-partnered study><computerized><depressed breathing><depression of breathing><design><designing><determine effectiveness><effectiveness and implementation trial><effectiveness assessment><effectiveness evaluation><effectiveness outcome><effectiveness-related outcomes><effectiveness/implementation hybrid study><effectiveness/implementation hybrid trial><effectiveness/implementation study><effectiveness/implementation trial><evaluate effectiveness><examine effectiveness><experience><falls><framework by proctor><heavy metal Pb><heavy metal lead><hospital re-admission><hospital readmission><hyperalgia><implementation framework><implementation outcomes><implementation research><implementation research framework><implementation science><implementation science framework><improved><improved outcome><innovate><innovation><innovative><intervention research><interventional research><interventional study><interventions research><medication administration><medication for opioid use disorder><mortality><mu opioid receptors><nursing administration><nursing standards><opiate consumption><opiate crisis><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate tolerance><opiate use><opiate use disorder><opioid consumption><opioid crisis><opioid drug overdose><opioid drug use><opioid epidemic><opioid habituation><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid tolerance><opioid toxicity><opioid use><opioid use disorder><pain intervention><pain relief><pain score><pain treatment><patient oriented outcomes><patient safety><pilot trial><poor health outcome><post implementation><premature><prematurity><proctor conceptual model><proctor implementation><proctor model><qualitative reasoning><randomisation><randomization><randomly assigned><re-admission><re-hospitalization><readmission><receptor><reduced health outcome><rehospitalization><relieve pain><research and development><return to use><safety outcomes><satisfaction><sedation><skills><tolerance to opiates><treatment as usual><usual care><worse health outcome><μ opioid receptors><μ-OR><μOR>

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Jennifer Susan Love

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$195,428

FY 2026

Project Title

ED-EXACT in Opioid Overdose: Emergency Department Evaluation of Xylazine-Associated Clinical Toxicity in Opioid Overdose

Grant Number:

1K23DA062172-01A1

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT: This K23 career development award will enable the candidate, Jennifer Love, MD, MSCR, to become an independent clinician-scientist focused on improving emergency care for patients with opioid use disorder (OUD) who are exposed to xylazine and novel adulterants. Xylazine, an...

Research Terms

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Katherine R Standish

BOSTON MEDICAL CENTER, BOSTON, MA

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$193,619

FY 2026

Project Title

Community-Engaged Development of a Peer Breastfeeding Support Intervention for Mothers with Opioid Use Disorder

Grant Number:

5K23DA061939-02

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT The incidence of opioid use disorder (OUD) in pregnancy and neonatal opioid withdrawal syndrome are rapidly increasing. OUD-exposed mother-infant dyads face increased medical and social risk in the perinatal period and beyond. Breastfeeding significantly improves key healt...

Research Terms

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Samantha Auty

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$193,180

FY 2026

Project Title

Medicaid Managed Care Network Adequacy and Its Impact on Access to Care for Pregnant Women with Opioid Use Disorder

Grant Number:

1K01DA064935-01

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2031

Why this may be worth a closer look

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Project Abstract

PROJECT SUMMARY The long-term goal of this K01 is to provide the mentorship and training necessary for Dr. Auty to become an independent investigator examining how Medicaid Managed Care (MMC) networks and policies influence access to care and health outcomes for individuals with opioid use disorder ...

Research Terms

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Nicholas A Giordano

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$192,780

FY 2026

Project Title

Differential Susceptibility for Developing Chronic Post-Surgical Pain Across Sleep Trajectories and Inflammatory Presentations

Grant Number:

5K23DA057415-04

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

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Project Abstract

PROJECT SUMMARY Insufficient and poor sleep is pervasive among individuals with shoulder conditions requiring surgical intervention. Impaired preoperative sleep has been shown to induce hyperalgesia, predict the onset of painful episodes, and result in worse postoperative pain outcomes. Given the co...

Research Terms

<(TNF)-α><Acute><Acute Pain><Acutely painful><Area><Arthroplasty><C-reactive protein><Cachectin><Characteristics><Chronic><Classification><Clinical Research><Clinical Study><Data><Data Collection><Delta Wave><Delta Wave sleep><Development><Devices><Drowsiness><Drug usage><Drugs><Electronics><Event><Hyperalgesia><Hyperalgesic Sensations><Impairment><Incidence><Individual><Inflammation><Inflammatory><Interleukins><Intervention><Joint Prosthesis Implantation><Leadership><Link><Longitudinal Studies><Longitudinal Surveys><Macrophage-Derived TNF><Measures><Medication><Mentors><Modeling><Monitor><Monocyte-Derived TNF><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Nature><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Orthopedic Surgery><Outcome><Pain><Pain Control><Pain Therapy><Pain intensity><Pain management><Painful><Participant><Pathway interactions><Patient Self-Report><Patients><Perioperative><Pharmaceutical Preparations><Post-operative Pain><Postoperative><Postoperative Pain><Postoperative Period><Predisposition><Prospective Studies><Proteins, specific or class, C-reactive><QOL><Quality of life><Reaction><Records><Replacement Arthroplasty><Reporting><Research><Risk><Risk Estimate><Role><Scientist><Self-Report><Shoulder><Sleep><Sleep Deprivation><Sleep disturbances><Slow-Wave Sleep><Somnolence><Surgical><Surgical Interventions><Surgical Procedure><Susceptibility><Symptoms><System><Systematics><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Time><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Visualization><aberrant sleep><actigraph><actigraphy><acute to chronic pain transition><biopsychosocial><career development><chronic pain><chronic pain patient><chronic pain transition><common symptom><cross-sectional investigation><cross-sectional research><cytokine><data captured from wearables><data collected from wearables><data collected using wearables><data gathered from wearable><data gathered through wearables><data gathered via wearable><deficient sleep><developmental><disrupted sleep><disturbed sleep><drug use><drug/agent><electronic><electronic device><experience><hyperalgia><impaired sleep><improved><inadequate sleep><inflammation marker><inflammatory marker><insufficient sleep><investigate cross-sectional><irregular sleep><joint arthroplasty><joint replacement><licit opioid><long-term study><longitudinal outcome studies><longitudinal research study><monitoring device><nociceptive response><novel><opiate consumption><opiate drug use><opiate intake><opiate medication><opiate therapy><opiate use><opioid consumption><opioid drug use><opioid intake><opioid medication><opioid therapy><opioid use><pain after surgery><pain chronification><pain intervention><pain outcome><pain sensitivity><pain treatment><pain-related outcome><pathway><patient centered><patient oriented><patient with chronic pain><poor sleep><post-surgical pain><postsurgical pain><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent><preventing><prospective research study><prospective survey><quality of sleep><skills><sleep amount><sleep debt><sleep deficiency><sleep deficit><sleep disruption><sleep duration><sleep dysregulation><sleep episode><sleep insufficiency><sleep interval><sleep length><sleep loss><sleep pattern><sleep period><sleep quality><sleep quantity><sleep routine><sleep schedule><sleep time><sleep/wake disruption><sleep/wake disturbance><sleep/wake patterns><sleepiness><social role><study cross-sectional><surgery><survey cross-sectional><systemic inflammation><systemic inflammatory response><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><transition to chronic pain><wearable><wearable data><wearable device><wearable device data><wearable electronics><wearable sensor data><wearable system><wearable technology><wearable tool><wearables>

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Jason M Tucciarone

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$192,720

FY 2026

Project Title

A patch circuit dissection of opioid addiction

Grant Number:

5K08DA055157-04

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT The opioid crisis remains a major health concern with millions of Americans addicted to opioid drugs and thousands of opioid related deaths per year. The sad reality is that while medication assisted therapies are highly effective, relapse rates remain high. More understandi...

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Jessica N. Flori

UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, FARMINGTON, CT

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$191,700

FY 2026

Project Title

Mechanisms of Action of Peer Recovery Support for People Receiving Opioid Use Disorder Treatment

Grant Number:

1K99DA062786-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Abstract The proposed K99/R00 award aims to guide the applicant to research independence, specifically in mechanisms of action (MoA) research of recovery support services for substance use disorders. The opioid epidemic is an ongoing public health crisis with opioid-related overdose deaths continuin...

Research Terms

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Alexander Ulintz

OHIO STATE UNIVERSITY, Columbus, OH

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$189,000

FY 2026

Project Title

Prospective Evaluation of Community Outreach via Emergency Medical Services to Individuals At-Risk for Overdose (PECO-EMS)

Grant Number:

1K08DA062758-01A1

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT This career development award will provide the didactic coursework, experiential training, and mentorship necessary for the candidate to become an independent clinician-scientist capable of developing and evaluating emergency medical services (EMS)-based interventions for su...

Research Terms

<911 call><Access to Care><Active Follow-up><Attitude><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Cessation of life><Client><Client satisfaction><Communities><Community Outreach><Data><Data Set><Death><Development><Drug usage><Early Intervention><Education><Educational aspects><Emergencies><Emergency Situation><Emergency medical service><Emergency response><Evaluation><Event><Face><Frequencies><Future><Goals><Harm Minimization><Harm Reduction><Health><Health Care Utilization><Health Promotion><Health Services Accessibility><Health Services Evaluation><Health Services Research><Hospitals><Individual><Injury><Intervention><Interview><Intuition><Investigation><Investigators><K-Awards><K-Series Research Career Programs><Medical><Medical Care Research><Mentors><Mentorship><Methods><Modeling><NIDA><Naloxone><Narcan><Narcanti><National Institute of Drug Abuse><National Institute on Drug Abuse><Ohio><Opiates><Opioid><Outcome><Outcome Assessment><Overdose><Participant><Patient Satisfaction><Patient Self-Report><Perception><Persons><Policies><Population><Position><Positioning Attribute><Prevention><Process><Program Description><Public Health><Qualifying><Records><Recovery Support><Recurrence><Recurrent><Regulation><Reporting><Research><Research Assistant><Research Career Program><Research Personnel><Research Resources><Researchers><Resources><Risk><Salutogenesis><Scientist><Self-Report><Services><Severities><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Substance Use Disorder><Survivors><Time><Time and Motion Studies><Training><Trust><Work><access to health services><access to services><access to treatment><accessibility to health services><active followup><addiction><addictive disorder><adverse consequence><adverse outcome><arm><availability of services><care access><career development><design><designing><developmental><distribute naloxone><drug use><emergency service><faces><facial><fentanyl test><follow up><follow-up><followed up><followup><health care service use><health care service utilization><health service access><health services availability><high risk group><high risk individual><high risk people><high risk population><improved><improved outcome><injuries><innovate><innovation><innovative><integrated care><integrated health care><integrated model of care><intuitive><investigate longitudinal><longitudinal care><longitudinal investigation><longitudinal research><medication for opioid use disorder><multidisciplinary><multiple substance use><multisubstance use><naloxone availability><naloxone dispensary><naloxone dispensation><naloxone dispensing><naloxone distribution><naloxone provision><next generation><observational cohort study><opiate consumption><opiate crisis><opiate drug use><opiate exposure><opiate intake><opiate overdose><opiate related overdose><opiate use><opioid consumption><opioid crisis><opioid drug overdose><opioid drug use><opioid epidemic><opioid exposure><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><outreach><overdose risk><participant engagement><patient engagement><peer><peer support><poly substance use><polysubstance use><prevent><preventing><primary outcome><programs><promoting health><prospective><provide naloxone><response><secondary outcome><service availability><service engagement><service intervention><service utilization><services engagement><services research><social stigma><statistical analysis><stigma><study longitudinal><substance use><substance use and disorder><substance using><survey longitudinal><test for fentanyl><test strip><treatment access>

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Paul Regier

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$187,916

FY 2026

Project Title

Integrating brain, neurocognitive, and computational tools in Opioid Use Disorder (OUD) to characterize executive function and to predict clinical outcomes

Grant Number:

5K01DA056700-04

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

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Project Abstract

Project Summary. The 5-year K01 Mentored Research Scientist proposal will employ brain, neurocognitive, and computational tools (e.g., deep learning) to understand the impact of opioid-use disorder (OUD) and common co-occurring issues on executive function and clinical outcomes. There have been reco...

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James Travis Donahoe

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$185,571

FY 2026

Project Title

Understanding Rising Overdose Mortality in Individuals with Low Socioeconomic Status

Grant Number:

1K01DA062902-01A1

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

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Project Abstract

ABSTRACT This K01 Mentored Research Scientist Development Award will support Dr. J. Travis Donahoe, a health economist and Assistant Professor at the University of Pittsburgh School of Public Health, in becoming an independent investigator whose research advances science about how to reduce substanc...

Research Terms

<21+ years old><Access to Care><Actiq><Address><Adult><Adult Human><American><Area><Automobile Driving><Award><Cessation of life><Communities><Community Surveys><Competence><County><Data><Data Set><Death><Demography><Development Plans><Disasters><Disparities><Disparity><Drug usage><Duragesic><Economics><Educational workshop><Epidemic><Fentanest><Fentanyl><Fentyl><Funding><Future><Grant><HEAL Initiative><Health><Health Services Accessibility><Helping End Addiction Long-term><Helping to End Addiction Long-term><History><Impoverished><Individual><Intervention><Investigators><K01 Award><K01 Mechanism><K01 Program><Knowledge><Legal><Link><Low Income Population><Low income group><Mentored Research Scientist Development Award><Mentored Training Award><Mentors><Mentorship><Methodology><Methods><Modeling><Morbidity><Municipalities><NIH><National Institutes of Health><Neighborhoods><Opiates><Opioid><Overdose><Overdose reduction><Pennsylvania><Persons><Phentanyl><Policies><Policy Analyses><Policy Analysis><Policy Maker><Population><Position><Positioning Attribute><Poverty><Proxy><Public Health><Public Health Schools><Qualitative Methods><Quasi-experiment><Quasi-experimental analysis><Quasi-experimental approach><Quasi-experimental design><Quasi-experimental methods><Quasi-experimental research><Quasi-experimental study><Quasi-experimental technique><Recording of previous events><Records><Research><Research Personnel><Research Scientist Development Award><Researchers><Risk><Science><Secure><Severities><Shapes><Side><Societies><Structure><Survey Instrument><Surveys><Testing><Time><Training><Translating><Trauma><United States National Institutes of Health><Universities><Vulnerable Populations><West Virginia><Work><Workshop><access to health care><access to health services><access to services><access to treatment><accessibility of health care><accessibility to health care><accessibility to health services><adulthood><apprentice><apprenticeship><assess effectiveness><availability of services><care access><career development><college><collegiate><combat><community engaged intervention><community informed intervention><community-partnered intervention><conference><convention><design><designing><determine effectiveness><develop therapy><disparities in mortality><distribute naloxone><driving><drug use><econometrics><economic><effectiveness assessment><effectiveness evaluation><evaluate effectiveness><examine effectiveness><health and care delivery><health care access><health care availability><health care delivery><health care service access><health care service availability><health data><health delivery systems><health service access><health services availability><health services delivery><high risk><high risk group><high risk individual><high risk people><high risk population><histories><human centered design><improved><innovate><innovation><innovative><intergenerational><intervention development><low SES><low income individual><low income people><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><manufacture><method development><mortality><mortality disparity><multidisciplinary><naloxone availability><naloxone dispensary><naloxone dispensation><naloxone dispensing><naloxone distribution><naloxone provision><novel><opiate crisis><opiate deaths><opiate mortality><opiate overdose><opiate related overdose><opioid crisis><opioid deaths><opioid drug overdose><opioid epidemic><opioid induced overdose><opioid intoxication><opioid medication overdose><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid toxicity><overdose death><overdose fatalities><overdose risk><policy evaluation><population health><professor><provide naloxone><public health intervention><qualitative reasoning><reduce overdose><reduced substance use><reduction in overdose><reduction in substance use><safety net><service availability><social><social determinants><social epidemiology><social stigma><sociodeterminant><stigma><substance use reduction><summit><symposia><symposium><therapy development><treatment access><treatment development><trend><vulnerable group><vulnerable individual><vulnerable people>

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Noa Krawczyk

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$178,657

FY 2026

Project Title

Beyond Treatment Initiation: Enhancing Opioid Use Disorder Care Transitions Across Health System Touchpoints

Grant Number:

5K01DA055758-04

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

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Project Abstract

7. PROJECT SUMMARY/ABSTRACT The opioid epidemic continues to rage, taking a vast toll on morbidity and mortality across the U.S. Despite efforts to expand availability of life-saving medications for opioid use disorder (MOUD), a significant gap re- mains in access to and continuity in these treatme...

Research Terms

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Daniel Larach

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$172,795

FY 2026

Project Title

Low-dose buccal buprenorphine: Relative abuse potential and postoperative analgesic acceptability

Grant Number:

5K23DA057387-04

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT About 25% of the 69,710 U.S. opioid overdose deaths in 2020 involved prescription opioids directly, and many of the remaining overdose victims started opioid use with prescribed medication. Post-surgical opioid prescribing comprises an increasing share of opioid prescribing, with considerab...

Research Terms

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Julie Rozelle Gaither

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$166,428

FY 2026

Project Title

The Clinical Challenges and Costs of Caring for Infants with Neonatal Opioid Withdrawal Syndrome (NOWS) in the Post-Nursery Period

Grant Number:

5K23HD109508-04

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2027

Why this may be worth a closer look

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Project Abstract

PROJECT SUMMARY The increased use of both prescription and illicit opioids among women of child-bearing age over the past two decades has resulted in a five-fold increase in neonatal opioid withdrawal syndrome (NOWS). The requisite monitoring and management of infants with NOWS prolong postnatal hos...

Research Terms

<0-11 years old><0-4 weeks old><21+ years old><Accidental Injury><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Area><Attention><Autonomic nervous system><Award><Birth><CNS Nervous System><Caring><Central Nervous System><Child><Child Abuse><Child Youth><Childhood Abuse><Children (0-21)><Children's Hospital><Clinical><Community Health Care><Development><Diagnosis><Disease><Disorder><Eating><Epidemiologist><Evidence based intervention><Family><Female of child bearing age><Female of childbearing age><Food Intake><Goals><HEAL Initiative><Health Care><Health Care Costs><Health Care Providers><Health Costs><Health Personnel><Helping End Addiction Long-term><Helping to End Addiction Long-term><Home><Home visitation><Hospital Admission><Hospital Costs><Hospitalization><Hospitalization cost><Hospitals><House Call><Infant><Infant Care><Injury><Intervention><Interview><Knowledge><Length of Stay><Life><Lived experience><Lived experiences><Maternal complication><Medical><Mentorship><Mission><Modeling><Monitor><Mothers><NICHD><NIH><National Institute of Child Health and Human Development><National Institutes of Health><Neonatal Abstinence Syndrome><Neonatal Opioid Withdrawal Syndrome><Neonatal Substance Withdrawal><Neonatal Withdrawal Syndrome><Neuraxis><Newborn Infant><Newborns><Number of Days in Hospital><Opiates><Opioid><Overdose><Parents><Parturition><Pediatric Hospitals><Pediatric Nursing><Pediatric/Adolescence Nursing><Personal Satisfaction><Postpartum Period><Protocol><Protocols documentation><Qualitative Research><Recovery><Research><Research Methodology><Research Methods><Research Resources><Resources><Risk><Safety><Site><Sleep><Social Workers><Stress><Structure><Substance Use Disorder><Time><Training><Unintentional Injury><United States National Institutes of Health><Work><active method><active technique><active treatment><adulthood><baby care><care costs><care utilization><career><career development><clinical care><community care><cost><cost effective><design><designing><developmental><economic analysis><economic assessment><economic evaluation><evidence base><gastrointestinal><health care personnel><health care worker><health data><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><high risk><high risk infant><home visit><homes><hospital days><hospital length of stay><hospital re-admission><hospital readmission><hospital stay><illicit opiate><illicit opioid><implementation science><improved outcome><infancy><infant health care><infant outcome><infantile><injuries><intersectionalities><intersectionality><juvenile><juvenile human><kids><large data sets><large datasets><licit opioid><maltreatment><maternal opiates use><maternal opioid use><maternal stress><medical care providers><medical college><medical personnel><medical schools><mistreatment><neglect><newborn abstinence syndrome><newborn care><newborn child><newborn children><opiate crisis><opiate medication><opiate use disorder><opioid crisis><opioid epidemic><opioid medication><opioid use disorder><parent><post-partum><postnatal><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent><preventing><re-admission><re-hospitalization><readmission><rehospitalization><relapse risk><research and methods><school of medicine><secondary analysis><skills><stressed mothers><substance use><substance use and disorder><substance using><treatment provider><vulnerable infant><well-being><wellbeing><women of child bearing age><women of childbearing age><youngster>

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Michael Joaquin Wedemeyer

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$163,350

FY 2026

Project Title

Molecular Regulation of the Kappa Opioid Receptor by 14-3-3 gamma

Grant Number:

1K99DA060953-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT The cost of treating pain in the United States exceeds $500 billion annually, yet pain remains a large problem with nearly one-third of the population reporting chronic pain. Opioids are very potent analgesics (i.e. relieve pain), but also have many negative effects such a...

Research Terms

<21+ years old><Absence of pain sensation><Absence of sensibility to pain><Address><Adult><Adult Human><Adverse effects><Afferent Neurons><American><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Anxiety><Assay><Attention><Behavior><Bioassay><Biochemical><Biochemistry><Bioinformatics><Biological Assay><Biological Chemistry><Biophysics><Biosensor><Brain><Brain Nervous System><CNS Nervous System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Co-Immunoprecipitations><Common Rat Strains><Complex><Computer Models><Computerized Models><Coupling><Cryo-electron Microscopy><Cryoelectron Microscopy><Cultured Cells><Dangerousness><Data><Development><Drug Targeting><Effectiveness><Electron Cryomicroscopy><Encephalon><Ensure><Family><Feels no pain><Foundations><Future><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G Protein-Coupled Receptor Signaling><G-Protein-Coupled Receptors><G-Proteins><GPCR><GPCR Signaling><GTP-Binding Proteins><GTP-Regulatory Proteins><Genetics-Mutagenesis><Goals><Grant><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><Health><Human><Hyperalgesia><Hyperalgesic Sensations><Image><In Vitro><Intracellular Communication and Signaling><Investigators><Knowledge><Link><Mediating><Mediator><Membrane><Mental Depression><Methods><Microscopy><Modeling><Modern Man><Molecular><Molecular Configuration><Molecular Conformation><Molecular Modeling Nucleic Acid Biochemistry><Molecular Modeling Protein/Amino Acid Biochemistry><Molecular Models><Molecular Stereochemistry><Mutagenesis><Mutagenesis Molecular Biology><Mutate><Nerve Cells><Nerve Unit><Neural Cell><Neural Transmission><Neuraxis><Neurocyte><Neurons><No sensitivity to pain><Nociception><Opiate Addiction><Opiate Dependence><Opiate Receptors><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid Receptor><Opioid Receptor Binding><Opioid agonist><Opioid receptor agonist><Optics><Pain><Pain Control><Pain Therapy><Pain management><Painful><Pathway interactions><Peripheral><Peripheral Nervous System><Pharmacology><Phase><Physiologic><Physiological><Population><Proteins><Public Health><Rat><Rats Mammals><Rattus><Receptor Inhibition><Receptor Protein><Receptor Signaling><Regulation><Regulatory Pathway><Reporting><Research><Research Personnel><Researchers><Resource Allocation><Respiratory Depression><Role><Scaffolding Protein><Scientist><Sedation procedure><Sensory Neurons><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Structure><Substance Use Disorder><Synaptic Transmission><Testing><Training><Transducers><United States><Ventilatory Depression><Work><addiction><addictive disorder><adulthood><analgesia><antinociception><antinociceptive><arrestin B><beta-arrestin><biological sensor><biological signal transduction><biophysical foundation><biophysical principles><biophysical sciences><career><chronic pain><computational modeling><computational models><computer based models><computerized modeling><conformation><conformational><conformational state><conformationally><conformations><cost><cryo-EM><cryoEM><cryogenic electron microscopy><depressed breathing><depression><depression of breathing><desensitization><design><designing><developmental><drug market><experiment><experimental research><experimental study><experiments><hyperalgia><imaging><improved><in vivo><innovate><innovation><innovative><insight><interdisciplinary approach><kappa opiate><kappa opioid><kappa opioid receptors><knock-down><knockdown><live cell microscopy><membrane structure><molecular modeling><multidisciplinary><multidisciplinary approach><neuronal><nociceptive><nor-BNI><nor-binaltorphimine><norbinaltorphimine><novel><opiate consumption><opiate crisis><opiate deaths><opiate drug use><opiate intake><opiate mortality><opiate overdose><opiate related overdose><opiate use><opioid addiction><opioid consumption><opioid crisis><opioid deaths><opioid dependence><opioid dependent><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid toxicity><opioid use><optical><pain intervention><pain killer><pain medication><pain relief><pain reliever><pain treatment><painkiller><pathway><pharmacologic><prevent><preventing><protein protein interaction><receptor><receptor-mediated signaling><reconstruction><relieve pain><scaffold><scaffolding><sedation><skills><social role><spatial and temporal><spatial temporal><spatiotemporal><stoichiometry><structural biology><substance use and disorder><superresolution microscopy><trafficking><β-arrestin><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR>

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Sandra Sanchez Roige

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 48/100

Likely hiring

Recent

Active award

$159,415

FY 2026

Project Title

Multivariate genome-wide association analysis of opioid-related traits in half a million diverse individuals

Grant Number:

3R01DA061977-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2025

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT We are in the middle of a global opioid epidemic. In 2020, 9.3 million Americans misused prescription opioid pain medications, with 8-12% going on to develop an opioid use disorder (OUD). OUD is highly heritable, but few of the relevant genes are known . A better understand...

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Ryan W Carpenter

UNIVERSITY OF NOTRE DAME, NOTRE DAME, IN

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$153,820

FY 2026

Project Title

Developing a modified brief alcohol-focused intervention tailored for patients with alcohol use disorder in opioid agonist treatment

Grant Number:

5K23AA029729-06

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2024

End Date:

2/28/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

7. Project Summary/Abstract This K23 Mentored Patient-Oriented Research Career Development Award involves complementary research and training plans to develop and then pilot a modified motivational enhancement therapy and cognitive behavioral therapy (MET-CBT) intervention tailored to target alcohol...

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Wenyu Song

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$198,520

FY 2026

Project Title

Linking Genetic and Clinical Data to Optimize Surgical Opioid Analgesic Prescribing and Predict Risks of Opioid-Related Adverse Drug Events

Grant Number:

5K01DA059572-03

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/15/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY While opioid drugs are very effective for controlling pain, they are highly addictive. The current clinical decision making for post-surgical opioid prescribing is still based on oversimplified information. Both opioid use disorder and opioid-related pain response have strong genetic...

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Danielle Rebecca Fine

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$197,640

FY 2026

Project Title

Peer recovery support for people experiencing homelessness with opioid use disorder

Grant Number:

5K23DA058200-03

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT People experiencing homelessness (PEH) are disproportionately affected by the opioid overdose crisis, with overdose rates up to 30-times higher than the general population. Medications for opioid use disorder (OUD) substantially reduce mortality, but retention in treatment...

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Crystal Lederhos Smith

WASHINGTON STATE UNIVERSITY, PULLMAN, WA

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$194,257

FY 2026

Project Title

Pharmacogenomic Testing to Optimize Opioid Use Disorder Treatment: Acceptability and Feasibility Trial

Grant Number:

5K01DA060359-02

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Research on Pharmacogenomics (PGx) and opioid use disorder treatment is rapidly expanding and supports the likely high impact of using PGx in opioid use disorder treatment, however most published studies have not researched the clinical application of PGx. To address this critical gap and e...

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Meredith Berry

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$192,852

FY 2026

Project Title

Opioid-Sparing and Pain-Reducing Properties of Syntocinon: A Dose-Effect Determination

Grant Number:

5K01DA052673-05

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Opioid misuse is a major source of morbidity and mortality in the U.S. and represents a pressing public health crisis. Opioid-related overdose deaths have more than quadrupled since 2002. Oxycodone (in Percocet™ and Oxycontin™) is reliably among the medications commonly prescribed for pain,...

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Cora Smiley

UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA, COLUMBIA, SC

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$192,149

FY 2026

Project Title

Noradrenergic mechanisms underlying stress-induced opioid reinstatement

Grant Number:

1K99DA062785-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The initiating factor for opioid use disorder often stems from comorbid neuropsychiatric conditions including anxiety, depression, and post-traumatic stress disorder. Experience of extreme or traumatic stress is often the underlying factor responsible for these neuropsychiatric condi...

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Paul John Christine

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$190,825

FY 2026

Project Title

Improving Methadone Patient-Centered Treatment (IMPaCT) to Enhance Retention in Care

Grant Number:

1K23DA064936-01

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Opioid overdose deaths remain at alarming levels, driven largely by illicitly manufactured fentanyl. Methadone is a highly effective medication for opioid use disorder (OUD) that reduces mortality by nearly 50%. Despite its demonstrated effectiveness, methadone's impact on O...

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Rafael E Perez

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$181,040

FY 2026

Project Title

Role of Anterior Cingulate Cortex Ensemble Regulation of Spinal Cord Excitability in Associative Opioid Analgesic Tolerance.

Grant Number:

5K99DA060951-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/15/2024

End Date:

12/31/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Opioid medications are highly prescribed for pain management. However, these drugs have considerable abuse liability. As users increase their opioid intake, they build tolerance against their therapeutic effects. Despite well- described molecular and cellular mechanisms, tolerance ca...

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Jihye Ryu

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$159,711

FY 2026

Project Title

Electrophysiological Dynamics of Acute Opioid Use in Human Reward, Affect, and Pain Pathways

Grant Number:

5K01DA060327-02

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Opioid use disorder (OUD) and chronic pain (CP) are interrelated, both impacting the brain's reward, affect, and pain circuits. OUD is prevalent among CP patients, and the euphoric effects and negative reinforcement properties of opioids are significant factors contributing to an increased ...

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DOUGLAS K OWENS

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 40/100

Above-average budget

Recent

Active award

$700,991

FY 2026

Project Title

Making Better Decisions: Policy Modeling for AIDS and Drug Abuse

Grant Number:

5R37DA015612-23

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/25/2022

End Date:

1/31/2029

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

The rise of fentanyl and stimulant use have dramatically worsened the national public health crisis of substance use in the US. The substance use epidemic continues to threaten hard-fought gains in prevention and control of HIV and hepatitis C virus (HCV) and related diseases. Identifying the best a...

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Ana M Abrantes

BUTLER HOSPITAL (PROVIDENCE, RI), PROVIDENCE, RI

Exploratory lead · 40/100

Solid budget

Recent

Active award

Team-scale grant

$498,005

FY 2026

Project Title

tDCS to Decrease Opioid Relapse

Grant Number:

5UH3DA047793-05

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2018

End Date:

12/31/2026

Project Abstract

Buprenorphine has emerged as a leading treatment for opioid use disorder (OUD), but recipients have high early relapse rates likely due to varying degrees of dysfunction within craving and cognitive control neuronal networks. Transcranial direct current stimulation (tDCS) may have promise as adjuvan...

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Michael D Stein

BUTLER HOSPITAL (PROVIDENCE, RI), PROVIDENCE, RI

Exploratory lead · 40/100

Solid budget

Recent

Active award

Team-scale grant

$498,005

FY 2026

Project Title

tDCS to Decrease Opioid Relapse

Grant Number:

5UH3DA047793-05

Activity Code:

UH3

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2018

End Date:

12/31/2026

Project Abstract

Buprenorphine has emerged as a leading treatment for opioid use disorder (OUD), but recipients have high early relapse rates likely due to varying degrees of dysfunction within craving and cognitive control neuronal networks. Transcranial direct current stimulation (tDCS) may have promise as adjuvan...

Research Terms

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Olimpia Meucci

DREXEL UNIVERSITY, PHILADELPHIA, PA

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$483,268

FY 2026

Project Title

Role of chemokines in neuronal function and survival

Grant Number:

5R37DA015014-24

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY OF PROPOSAL Modern antiretroviral therapies have transformed Human Immunodeficiency Virus (HIV) infection into a chronically manageable disease. However, a significant amount of people with HIV on antiretroviral therapies present with a spectrum of neurological symptoms. These HIV-associat...

Research Terms

<2-photon microscopy><21+ years old><3-D><3-Dimensional><3D><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adjuvant Therapy><Adult><Adult Human><Affect><Age><Animal Model><Animal Models and Related Studies><Anti-HIV Positivity><Architecture><Award><Back><Body Tissues><Brain><Brain Nervous System><C-X-C Chemokine Receptor Type 4><CD184 Antigen><CNS Nervous System><CXC-R4><CXCL12><CXCL12 gene><CXCL12 protein><CXCR-4><CXCR4><CXCR4 Receptors><CXCR4 gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Chemokine (C-X-C Motif) Ligand 12><Chemokine (C-X-C Motif) Receptor 4><Chemokine Receptor Gene><Chemokine, CXC Motif, Receptor 4><Chemotactic Cytokines><Chronic><Clinical><Clinical Management><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Collaborations><Common Rat Strains><Complement><Complement Proteins><Complex><Connector Neuron><Coupled><Cyclic Somatostatin><D2S201E><Dendritic Spines><Development><Disease><Disorder><Disturbance in cognition><Dorsum><Dysfunction><Electrophysiology><Electrophysiology (science)><Encephalon><Engineering / Architecture><Environment><Event><FB22><Functional disorder><Fusin><Future><Glia><Glial Cells><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><HIV><HIV 1 associated neurocognitive disorder><HIV Positive><HIV Positivity><HIV Seroconversion><HIV Seropositivity><HIV antibody positive><HIV associated neurocognitive deficit><HIV associated neurocognitive impairment><HIV associated neurological disease><HIV associated neurological disorder><HIV individuals><HIV induced neurocognitive deficit><HIV induced neurocognitive impairment><HIV infected individuals><HIV infected persons><HIV intervention><HIV neurocognitive impairment><HIV people><HIV positive individuals><HIV positive people><HIV therapeutic><HIV therapy><HIV treatment><HIV+><HIV-1 associated neurocognitive deficit><HIV-1 associated neurocognitive disorder><HIV-1 associated neurocognitive impairment><HIV-1 intervention><HIV-1 therapeutic><HIV-1 therapy><HIV-1 treatment><HIV-associated neurocognitive disorder><HM89><HSY3RR><HTLV-III Seroconversion><HTLV-III Seropositivity><Health><Homologous Chemotactic Cytokines><Human><Human Immunodeficiency Virus therapy><Human Immunodeficiency Virus treatment><Human Immunodeficiency Viruses><Image><Impaired cognition><Individual><Infection><Inflammation Mediators><Infumorph><Intercalary Neuron><Intercalated Neurons><Intercrines><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><Kadian><Knowledge><Kolliker's reticulum><LAP3><LAV-HTLV-III><LCR1><LESTR><LESTR Receptor><LPS-Associated Protein 3><Learning><Leukocyte-Derived Seven-Transmembrane Domain Receptor><Ligands><Link><Lipopolysaccharide-Associated Protein 3><Lymphadenopathy-Associated Virus><MS Contin><MSir><Measures><Medial><Mediating><Memory><Methods><Modeling><Modern Man><Modernization><Molecular><Monitor><Morphia><Morphine><NPY3R><NPYR><NPYRL><NPYY3R><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Network-based><Neural Cell><Neuraxis><Neurobiology><Neurocognitive Impairment in HIV><Neurocognitive Impairment in HIV-1><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic Disorders><Neurologic Manifestations><Neurologic Signs and Symptoms><Neurologic Symptoms><Neurological Disorders><Neurological Manifestations><Neurological Signs and Symptoms><Neurons><Neuropeptide Y Receptor Y3><Neurophysiology / Electrophysiology><Neurosurgeon><Neurotoxins><Non-neuronal cell><Nonneuronal cell><Opiate Receptors><Opiate agonist><Opiate receptor agonist><Opiate user><Opiates><Opioid><Opioid Receptor><Opioid agonist><Opioid drug user><Opioid receptor agonist><Oramorph><Oramorph SR><Outcome><PBSF><PLWH><PWH><PWUO><Pathology><Pathway interactions><Patients><Personal Satisfaction><Physiopathology><Population><Pre-B Cell Growth Stimulating Factor><Prefrontal Cortex><Process><Prognosis><Proteins><Pyramidal neuron><Rat><Rats Mammals><Rattus><Receptor Protein><Regulation><Rodent><Rodentia><Rodents Mammals><Role><Roxanol><SCYB12><SDF-1><SDF-1 Receptor><SDF-1A><SDF-1B><SDF-1alpha><SDF1><SDF1/PBSF Receptor CXCR4><SDF1A><SDF1B><SIS cytokines><SRIH><SRIH-14><Sdf1 protein><Signal Transduction><Signal Transduction Systems><Signaling><Site><Slice><Somatostatin><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><Spinal Column><Spine><Spleen Seven-Transmembrane-Segment Receptor><Statex SR><Stimulus><Stromal Cell-Derived Factor 1><Stromal Cell-Derived Factor 1 Receptor><Substance Use Disorder><Substance abuse problem><Synapses><Synaptic><Synaptic plasticity><System><TLSF-A><TLSF-B><TPAR1><Techniques><Testing><Therapeutic><Tissues><Transgenic Model><Transgenic Organisms><Translating><Vertebral column><Viral Gene Products><Viral Gene Proteins><Viral Proteins><Virus-HIV><Work><abuse of substances><adjuvant treatment><adulthood><ages><antiretroviral therapy><antiretroviral treatment><backbone><behavior study><behavioral study><biological signal transduction><chemoattractant cytokine><chemokine><chemokine receptor><cognitive defects><cognitive dysfunction><cognitive loss><complementation><dendrite spine><developmental><electrophysiological><flexibility><flexible><growth hormone release inhibiting factor><hIRH><hippocampal pyramidal neuron><imaging><improved><in vivo><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><inflammatory mediator><inhibitory neuron><insight><interest><knock-down><knockdown><model of animal><multi-electrode arrays><multielectrode arrays><nerve cement><neural manifestation><neuro-AIDS><neuro-HIV><neuro-surgeon><neuroAIDS><neuroHIV><neurobiological><neurocognitive test><neurological disease><neuronal><neuroprotection><neuroprotective><neuropsychiatric><neuropsychiatry><neurotoxic><neurotoxicant><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><opiate consumption><opiate drug use><opiate intake><opiate use><opioid consumption><opioid drug use><opioid intake><opioid use><opioid user><optogenetics><pathophysiology><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people who use opioids><people with HIV><people with human immunodeficiency virus><persons who use opioids><preservation><receptor><recruit><social role><stromal cell-derived factor-1alpha><substance abuse><substance use and disorder><synapse><therapeutic evaluation><therapeutic testing><three dimensional><transgenic><transgenic trait><translational applications><treat HIV><treat Human Immunodeficiency Virus><two photon excitation microscopy><two photon microscopy><validation studies><virus protein><well-being><wellbeing>

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Karen Alexander

FRIENDS RESEARCH INSTITUTE, INC., BALTIMORE, MD

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$448,565

FY 2026

Project Title

Empowering Support Persons to Enhance the Recovery Capital of Postpartum Women with Opioid Use Disorder

Grant Number:

1R61DA064704-01

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Opioid agonist treatment (OAT) is highly effective in preventing morbidity and mortality related to opioid use disorder (OUD), but long-term engagement is complicated by physical, social, and structural factors, especially for women. Postpartum women with OUD face the challe...

Research Terms

<0-4 weeks old><Address><Capital><Caring><Child Welfare><Clinical Trials><Collaborations><Communication><Communities><Complex><Data><Development><Education><Educational aspects><Emotional><Face><Family><Family member><Fear><Feedback><Fostering><Foundations><Friends><Fright><Goals><Health Care Providers><Health Personnel><Hospitals><Individual><Intervention><Judgment><Knowledge><Life Cycle><Life Cycle Stages><Lived experience><Lived experiences><Measures><Morbidity><Mothers><Motivation><Newborn Infant><Newborns><Opiates><Opioid><Outcome><Parents><Participant><Patients><Persons><Phase><Play><Post-partum Women><Postpartum Period><Postpartum Women><Process><Public Health><Randomization trial><Randomized, Controlled Trials><Recovery><Recovery Support><Research><Research Design><Research Resources><Resources><Role><Self Efficacy><Services><Site><Social Network><Source><Study Type><Techniques><Training><Training Programs><Training Support><Treatment outcome><Vulnerable Populations><Woman><acceptability and feasibility><adolescent welfare><assess effectiveness><care as usual><care coordination><care resources><care services><care systems><child well being><child wellbeing><coordinating care><cost effective><design><designing><determine effectiveness><developmental><effectiveness assessment><effectiveness evaluation><emotional distress><empowerment><evaluate effectiveness><examine effectiveness><faces><facial><feeling distress><feeling upset><health assessment><health care personnel><health care resources><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><high risk><hospital care><human capital><improved><innovate><innovation><innovative><intervention design><intervention effect><life course><loved ones><medical care providers><medical personnel><mortality><motivational enhancement therapy><motivational interview><newborn child><newborn children><opiate use disorder><opioid agonist therapy><opioid agonist treatment><opioid use disorder><overdose risk><parent><patient navigation><patient navigator><pilot test><post-partum><prevent><preventing><primary outcome><randomized control trial><randomized trial><randomized, clinical trials><secondary outcome><skills><social><social attachment><social bonding><social capital><social factors><social role><standard care><standard treatment><structural determinants><structural factors><study design><substance use><substance using><theories><therapy design><tool><treatment as usual><treatment design><treatment provider><usual care><vulnerable group><vulnerable individual><vulnerable people>

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Sara L. Kornfield

FRIENDS RESEARCH INSTITUTE, INC., BALTIMORE, MD

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$448,565

FY 2026

Project Title

Empowering Support Persons to Enhance the Recovery Capital of Postpartum Women with Opioid Use Disorder

Grant Number:

1R61DA064704-01

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Opioid agonist treatment (OAT) is highly effective in preventing morbidity and mortality related to opioid use disorder (OUD), but long-term engagement is complicated by physical, social, and structural factors, especially for women. Postpartum women with OUD face the challe...

Research Terms

<0-4 weeks old><Address><Capital><Caring><Child Welfare><Clinical Trials><Collaborations><Communication><Communities><Complex><Data><Development><Education><Educational aspects><Emotional><Face><Family><Family member><Fear><Feedback><Fostering><Foundations><Friends><Fright><Goals><Health Care Providers><Health Personnel><Hospitals><Individual><Intervention><Judgment><Knowledge><Life Cycle><Life Cycle Stages><Lived experience><Lived experiences><Measures><Morbidity><Mothers><Motivation><Newborn Infant><Newborns><Opiates><Opioid><Outcome><Parents><Participant><Patients><Persons><Phase><Play><Post-partum Women><Postpartum Period><Postpartum Women><Process><Public Health><Randomization trial><Randomized, Controlled Trials><Recovery><Recovery Support><Research><Research Design><Research Resources><Resources><Role><Self Efficacy><Services><Site><Social Network><Source><Study Type><Techniques><Training><Training Programs><Training Support><Treatment outcome><Vulnerable Populations><Woman><acceptability and feasibility><adolescent welfare><assess effectiveness><care as usual><care coordination><care resources><care services><care systems><child well being><child wellbeing><coordinating care><cost effective><design><designing><determine effectiveness><developmental><effectiveness assessment><effectiveness evaluation><emotional distress><empowerment><evaluate effectiveness><examine effectiveness><faces><facial><feeling distress><feeling upset><health assessment><health care personnel><health care resources><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><high risk><hospital care><human capital><improved><innovate><innovation><innovative><intervention design><intervention effect><life course><loved ones><medical care providers><medical personnel><mortality><motivational enhancement therapy><motivational interview><newborn child><newborn children><opiate use disorder><opioid agonist therapy><opioid agonist treatment><opioid use disorder><overdose risk><parent><patient navigation><patient navigator><pilot test><post-partum><prevent><preventing><primary outcome><randomized control trial><randomized trial><randomized, clinical trials><secondary outcome><skills><social><social attachment><social bonding><social capital><social factors><social role><standard care><standard treatment><structural determinants><structural factors><study design><substance use><substance using><theories><therapy design><tool><treatment as usual><treatment design><treatment provider><usual care><vulnerable group><vulnerable individual><vulnerable people>

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Karen L Cropsey

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$447,000

FY 2026

Project Title

Remote Fentanyl Test Strip Distribution and Education to Prevent Drug Overdose

Grant Number:

1R61DA065247-01

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This Type 1 hybrid effectiveness-implementation randomized controlled trial, Remote Fentanyl Test Strip Distribution and Education to Prevent Drug Overdose, aims to address the United States opioid crisis driven by fentanyl and other synthetic opioids. Fentanyl test strips (FTS) are a cheap, low bur...

Research Terms

<4-arm study><Actiq><Address><Affect><Application Context><Assess implementation><Behavior><Behavioral><Behavioral Model><Cities><Cocaine><Collaborations><Collection><Control Groups><Cost Analyses><Cost Analysis><Cost Effectiveness Analysis><Data><Development><Diacetylmorphine><Diamorphine><Drug Costs><Drug user><Drugs><Duragesic><Ecological momentary assessment><Education><Education for Intervention><Educational Intervention><Educational aspects><Enrollment><Exclusion><Fentanest><Fentanyl><Fentyl><Future><Health><Heroin><Implementation assessment><Individual><Instruction Intervention><Intervention><Knowledge><Legal><Medication><Methods><Modeling><Modification><NIDA><Naloxone><Narcan><Narcanti><National Institute of Drug Abuse><National Institute on Drug Abuse><Opiates><Opioid><Outcome><Overdose><Overdose reduction><PWUD><Participant><Persons><Pharmaceutical Preparations><Phase><Phentanyl><Preventative intervention><Process><Randomized><Randomized, Controlled Trials><Reporting><Research><Research Resources><Resources><Risk Reduction><Services><Site><Social support><Stimulant><Survey Instrument><Surveys><Testing><Time><Training Intervention><Trust><United States><Vulnerable Populations><Work><Writing><acceptability and feasibility><assess cost><assess effectiveness><community based organizations><community organizations><community partners><community-based partners><concept mapping><concept maps><contextual factors><cost><cost assessment><cost effective><cost efficient><cost efficient analysis><cost evaluation><cost-effective analysis><design><designing><determine effectiveness><developmental><dissemination strategy><distribute naloxone><drug/agent><effectiveness and implementation trial><effectiveness assessment><effectiveness evaluation><effectiveness-implementation RCT><effectiveness-implementation randomized control trial><effectiveness-implementation randomized controlled trial><effectiveness/implementation hybrid><effectiveness/implementation hybrid trial><effectiveness/implementation trial><enroll><evaluate cost><evaluate effectiveness><evaluate implementation><evaluation of implementation><examine cost><examine effectiveness><fentanyl test><fentanyl use><four-arm study><human centered design><illicit opiate><illicit opioid><implementation evaluation><insight><instructional intervention><intervention for prevention><manufacture><naloxone availability><naloxone dispensary><naloxone dispensation><naloxone dispensing><naloxone distribution><naloxone provision><novel><opiate consumption><opiate crisis><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opioid consumption><opioid crisis><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><overdose death><overdose education><overdose fatalities><overdose prevention><overdose risk><people who use drugs><people who use illicit drugs><persons who use drugs><prevent><preventing><prevention intervention><preventional intervention strategy><preventive intervention><programs><provide naloxone><psychostimulant use><randomisation><randomization><randomized control trial><randomly assigned><recruit><reduce overdose><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><reduction in overdose><remote intervention><risk-reducing><rural area><rural location><rural region><secondary outcome><service engagement><services engagement><social factors><social media><social support network><stimulant use><substance use><substance using><synthetic opiate><synthetic opioid><test for fentanyl><test strip><tool><trial design><uptake><use of stimulants><vulnerable group><vulnerable individual><vulnerable people><wasting>

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Emma Sophia Kay

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$447,000

FY 2026

Project Title

Remote Fentanyl Test Strip Distribution and Education to Prevent Drug Overdose

Grant Number:

1R61DA065247-01

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

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• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This Type 1 hybrid effectiveness-implementation randomized controlled trial, Remote Fentanyl Test Strip Distribution and Education to Prevent Drug Overdose, aims to address the United States opioid crisis driven by fentanyl and other synthetic opioids. Fentanyl test strips (FTS) are a cheap, low bur...

Research Terms

<4-arm study><Actiq><Address><Affect><Application Context><Assess implementation><Behavior><Behavioral><Behavioral Model><Cities><Cocaine><Collaborations><Collection><Control Groups><Cost Analyses><Cost Analysis><Cost Effectiveness Analysis><Data><Development><Diacetylmorphine><Diamorphine><Drug Costs><Drug user><Drugs><Duragesic><Ecological momentary assessment><Education><Education for Intervention><Educational Intervention><Educational aspects><Enrollment><Exclusion><Fentanest><Fentanyl><Fentyl><Future><Health><Heroin><Implementation assessment><Individual><Instruction Intervention><Intervention><Knowledge><Legal><Medication><Methods><Modeling><Modification><NIDA><Naloxone><Narcan><Narcanti><National Institute of Drug Abuse><National Institute on Drug Abuse><Opiates><Opioid><Outcome><Overdose><Overdose reduction><PWUD><Participant><Persons><Pharmaceutical Preparations><Phase><Phentanyl><Preventative intervention><Process><Randomized><Randomized, Controlled Trials><Reporting><Research><Research Resources><Resources><Risk Reduction><Services><Site><Social support><Stimulant><Survey Instrument><Surveys><Testing><Time><Training Intervention><Trust><United States><Vulnerable Populations><Work><Writing><acceptability and feasibility><assess cost><assess effectiveness><community based organizations><community organizations><community partners><community-based partners><concept mapping><concept maps><contextual factors><cost><cost assessment><cost effective><cost efficient><cost efficient analysis><cost evaluation><cost-effective analysis><design><designing><determine effectiveness><developmental><dissemination strategy><distribute naloxone><drug/agent><effectiveness and implementation trial><effectiveness assessment><effectiveness evaluation><effectiveness-implementation RCT><effectiveness-implementation randomized control trial><effectiveness-implementation randomized controlled trial><effectiveness/implementation hybrid><effectiveness/implementation hybrid trial><effectiveness/implementation trial><enroll><evaluate cost><evaluate effectiveness><evaluate implementation><evaluation of implementation><examine cost><examine effectiveness><fentanyl test><fentanyl use><four-arm study><human centered design><illicit opiate><illicit opioid><implementation evaluation><insight><instructional intervention><intervention for prevention><manufacture><naloxone availability><naloxone dispensary><naloxone dispensation><naloxone dispensing><naloxone distribution><naloxone provision><novel><opiate consumption><opiate crisis><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opioid consumption><opioid crisis><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><overdose death><overdose education><overdose fatalities><overdose prevention><overdose risk><people who use drugs><people who use illicit drugs><persons who use drugs><prevent><preventing><prevention intervention><preventional intervention strategy><preventive intervention><programs><provide naloxone><psychostimulant use><randomisation><randomization><randomized control trial><randomly assigned><recruit><reduce overdose><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><reduction in overdose><remote intervention><risk-reducing><rural area><rural location><rural region><secondary outcome><service engagement><services engagement><social factors><social media><social support network><stimulant use><substance use><substance using><synthetic opiate><synthetic opioid><test for fentanyl><test strip><tool><trial design><uptake><use of stimulants><vulnerable group><vulnerable individual><vulnerable people><wasting>

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Michael R. Bruchas

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$426,589

FY 2026

Project Title

DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCE

Grant Number:

5R37DA033396-14

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2013

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Despite recent efforts to curb use, nicotine use is at an all time high, is responsible for millions of deaths each year and remains one of the most difficult drugs to stop using. While there are many reports of opioid receptor, specifically Kappa-opioid receptor dependent regulation of drug-seeking...

Research Terms

<Adeno-Associated Viruses><Affective Disorders><Alcohol Chemical Class><Alcohols><Ammon Horn><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anxiety><Associated Viruses><Behavior><Behavioral><Behavioral Model><Biological><Brain><Brain Nervous System><CRE Recombinase><CRISPR><CRISPR/Cas system><CaM KII><CaM PK II><CaM kinase II><CaMKII><Calcium><Cartoons><Cell Body><Cells><Cessation of life><Chemosensitization><Chemosensitization/Potentiation><Claustral structure><Claustrum><Clustered Regularly Interspaced Short Palindromic Repeats><Cocaine><Cornu Ammonis><Corpus Striatum><Corpus striatum structure><Death><Dependoparvovirus><Dependovirus><Diacetylmorphine><Diamorphine><Dorsal><Drug Regulations><Drug abuse><Drugs><Dynorphins><Electrophysiology><Electrophysiology (science)><Encephalon><Enterobacteria phage P1 Cre recombinase><Genetic><Glutamates><Heroin><Hippocampus><Image><In vivo two-photon calcium imaging><Instruction><L-Glutamate><Learning><Ligands><Link><Measures><Mediating><Medication><Memory><Methods><Mice><Mice Mammals><Modeling><Mood Disorders><Motivation><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuropharmacology><Neurophysiology / Electrophysiology><Nicotine><Nicotine Dependence><Nucleus Accumbens><Opiate Addiction><Opiate Dependence><Opiate Peptides><Opiate Receptors><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid Peptide><Opioid Receptor><Opioid agonist><Opioid receptor agonist><Outcome><Pharmaceutical Preparations><Pharmacology><Photometry><Play><Potentiation><Process><Receptor Activation><Receptor Protein><Regulation><Relapse><Reporting><Rewards><Risk><Role><Satellite Viruses><Self Administered><Self Administration><Site><Slice><Stress><Striate Body><Striatum><Synapses><Synaptic><Synaptic plasticity><System><Testing><Therapeutic Intervention><Time><Tobacco><Ventral Striatum><Viral><Work><abuse of drugs><abused drug><abused drugs><abuses drugs><adeno associated virus group><amygdaloid nuclear complex><bacteriophage P1 recombinase Cre><biologic><calcium-dependent CaM kinase II><calmodulin-dependent protein kinase II><cell type><drug abused><drug of abuse><drug seeking behavior><drug/agent><drugs abused><drugs of abuse><electrophysiological><endogenous opiate><endogenous opioids><endomicroscopy><experience><experiment><experimental research><experimental study><experiments><gain of function><genetic approach><genetic strategy><glutamatergic><hippocampal><imaging><in vivo><in vivo calcium imaging><interdisciplinary approach><intervention therapy><kappa opiate><kappa opioid><kappa opioid receptors><lead candidate><microendoscopy><mouse genetics><mouse model><multidisciplinary approach><murine model><neural circuit><neural circuitry><neurocircuitry><neuronal><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><nicotine addiction><nicotine consumption><nicotine dependent><nicotine reward><nicotine seeking><nicotine seeking behavior><nicotine self-administration><nicotine treatment><nicotine use><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><opioid addiction><opioid dependence><opioid dependent><optogenetics><parabrachial nucleus><pharmacologic><preference><presynaptic><receptor><receptor expression><recruit><social role><striatal><synapse><synaptic circuit><synaptic circuitry><viral rescue><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR>

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Nicoletta K Memos

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$78,040

FY 2026

Project Title

Mu Opioid Receptors and Splice Variant Expression in Neonate Autoresuscitation

Grant Number:

5F32HL170536-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

2/26/2024

End Date:

2/25/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/ Abstract Sudden Infant Death Syndrome takes the lives of approximately 1,400 infants annually under the age of one and its etiology remains mostly unknown. Currently SIDS is explained via the triple risk model that proposes that SIDS occurs in a vulnerable infant during a critical d...

Research Terms

<0 year old><<1 year old><<1-year-old><<12 months of age><Address><Affect><Age><Air><Anoxia><Blood><Blood Reticuloendothelial System><Body Tissues><Brain><Brain Nervous System><Brain Stem><Brainstem><Breathing><CO2><Carbon Dioxide><Carbonic Anhydride><Case Study><Case-Base Studies><Causality><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cessation of life><Congenital Disorders><Cot Death><Crib Death><DNA mutation><Death><Development><Developmental Anatomy><Diagnostic><Disease><Disorder><Dysfunction><Educational workshop><Encephalon><Environment><Esthesia><Etiology><Exclusion><Exons><Exposure to><Face><Failure><Foundations><Functional disorder><Gases><Gene Expression><Gene Splicing><Gene variant><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genetic predisposing factor><Goals><Hypercapnia><Hypoxia><Hypoxic><In Vitro><Infant><Infant Mortality><Infant Mortality Total><Intracellular Communication and Signaling><Investigation><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Length><Literature><Membrane><Mice><Mice Mammals><Modeling><Molecular Target><Murine><Mus><Mutation><Neonatal><Neonatal Abstinence Syndrome><Neonatal Opioid Withdrawal Syndrome><Neonatal Substance Withdrawal><Neonatal Withdrawal Syndrome><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neurocyte><Neuronal Transmission><Neurons><Nociception><Nucleotides><Nucleus><Null Mouse><O element><O2 element><Opiate Receptors><Opiates><Opioid><Opioid Receptor><Outcome><Oxygen><Oxygen Deficiency><Pathogenicity><Pathology><Pattern><Physiopathology><Play><Point Mutation><Process><RNA Splicing><Receptor Signaling><Reflex><Reflex action><Regulation><Reporting><Research><Respiration><Respiration Disorders><Respiratory Aspiration><Respiratory Center><Respiratory Depression><Respiratory Disorder><Respiratory Inspiration><Risk><Risk Factors><Role><SIDS><Sensation><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Spices><Spliced Genes><Splicing><Structure><Sudden Infant Death><Sudden Unexpected Infant Death><Sudden infant death syndrome><Technology><Testing><Therapeutic Intervention><Tissues><Training><Variant><Variation><Ventilatory Depression><Work><Workshop><age 0><age <1-year><ages><allelic variant><axon signaling><axon-glial signaling><axonal signaling><biological signal transduction><breathing disorder><carbon dioxide retention><cardiac function><case report><causation><class development><congenital respiratory disorder><course development><course material development><critical developmental period><death among infants><death in first year of life><death in infancy><death in infants><depressed breathing><depression of breathing><developmental><diagnostic development><disease causation><elevated carbon dioxide><environment enrichment><environment enrichment for laboratory animals><environmental enrichment><environmental enrichment for laboratory animals><exposed in utero><faces><facial><fetal exposure><function of the heart><gene function><genetic risk factor><genetic variant><genome mutation><genomic variant><glia signaling><glial signaling><heart function><high risk infant><hypercarbia><in utero exposure><increased level Carbon dioxide><infant death><infant demise><infantile death><inherited factor><insight><inspiration><intervention therapy><intra-uterine environmental exposure><intrauterine environmental exposure><knockout gene><less than 1 year of age><less than 1 year old><less than 12 months of age><less than one year of age><less than one year old><loss of function><membrane structure><mortality in infants><mouse model><mu opioid receptors><murine model><neonatal breathing><neonatal mice><neonatal respiration><neonatal respiratory><neonate><nerve signaling><neural signaling><neuronal><neuronal signaling><neurotransmission><newborn abstinence syndrome><newborn breathing><newborn respiratory><nociceptive><opiate consumption><opiate drug use><opiate intake><opiate overdose><opiate related overdose><opiate use><opioid consumption><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><pathophysiology><preBotzinger complex><prenatal exposure><prenatally exposed><respiratory><respiratory dysfunction><respiratory mechanism><respiratory reflex><response><sleep position><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stressor><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic biomarker><therapeutic development><therapeutic marker><unclassified variant><under 1 year of age><under 1 year old><under 12 months of age><under one year of age><under one year old><variant of uncertain clinical significance><variant of uncertain significance><variant of undetermined significance><variant of unknown significance><vulnerable infant><μ opioid receptors><μ-OR><μOR>

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Micaela Vela Ruiz

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$46,988

FY 2026

Project Title

Serotonin and dopamine dynamics during kappa opioid mediated aversion

Grant Number:

1F31DA065365-01

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/16/2026

End Date:

3/15/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ NARRATIVE Substance use disorder affects about 24 million people in the US due to the heightened availability of psychostimulants and synthetic opioids. Drug overdose deaths have also dramatically increased, requiring an urgent need to develop new therapeutics for this ongoing epide...

Research Terms

<5-HT><5-HT pathway><5-HT system><5-Hydroxytryptamine><5HT><5HT transporter><5HTT protein><Abscission><Affect><Affective Disorders><Agonist><Animals><Behavioral><CRISPR><CRISPR/Cas system><Cell Body><Cells><Chemical Dependence><Chemosensitization><Chemosensitization/Potentiation><Clustered Regularly Interspaced Short Palindromic Repeats><Cocaine><Color><Coupled><Cues><DA Neuron><Development><Dopamine><Dopamine neuron><Drug Addiction><Drug Dependence><Drug Dependency><Drugs><Dynorphins><Enteramine><Epidemic><Equilibrium><Ethics><Excision><Extirpation><Fiber><Foundations><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Gene Deletion><Genes><Genetic Polymorphism><Hippophaine><Human><Hydroxytyramine><Image><Individual><Infumorph><Investigators><Kadian><Knowledge><Learning><Link><MAP kinase><MS Contin><MSir><Measures><Mediating><Medication><Mice><Mice Mammals><Mitogen-Activated Protein Kinases><Modern Man><Modernization><Mood Disorders><Morphia><Morphine><Murine><Mus><Nerve><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neurocyte><Neuronal Transmission><Neurons><Neuropeptides><Neuropharmacology><Nucleus Accumbens><Opiate Antagonist><Opiate agonist><Opiate receptor agonist><Opiate receptor antagonist><Opiates><Opioid><Opioid Antagonist><Opioid agonist><Opioid receptor agonist><Opioid receptor antagonist><Oramorph><Oramorph SR><Persons><Pharmaceutical Preparations><Photometry><Potentiation><Predisposition><Professional Competence><Property><Receptor Activation><Recovery><Regulation><Removal><Research><Research Personnel><Researchers><Resolution><Rewards><Risk><Role><Roxanol><Serotonergic System><Serotonin><Statex SR><Stress><Substance Use Disorder><Substance abuse problem><Surgical Removal><Susceptibility><Swimming><System><Techniques><Therapeutic><Therapeutic Intervention><Time><Training><Ventral Tegmental Area><Withdrawal><abuse of substances><addiction><addictive disorder><antagonism><antagonist><axon signaling><axon-glial signaling><axonal signaling><balance><balance function><behavior response><behavioral response><biological adaptation to stress><career><career skill><co-exposures><co-occurring exposure><combined exposure><complex exposure><concurrent exposure><developmental><dopamine system><dopaminergic neuron><dorsal raphe nucleus><drug abstinence><drug relapse><drug/agent><dysphoria><ethical><exposure mixture><extracellular><gene deletion mutation><glia signaling><glial signaling><imaging><in vivo><inhibitor><insight><intervention therapy><kappa opiate><kappa opioid><kappa opioid receptors><mixed exposure><nerve signaling><neural signaling><neuronal><neuronal signaling><neurotransmission><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overdose death><overdose fatalities><pharmacologic><polymorphism><pre-clinical><preclinical><preference><presynaptic><prodynorphin><psychostimulant><reactioncrisis><real time monitoring><realtime monitoring><recruit><resection><resilient to stress><resolutions><response><reuptake><sensor><serotonergic pathway><serotonin pathway><serotonin system><serotonin transporter><simultaneous exposures><skills><social role><sodium-dependent serotonin transporter><spatial and temporal><spatial temporal><spatiotemporal><stress related disorder><stress resilience><stress resiliency><stress response><stressreaction><substance abuse><substance use and disorder><success><synapse inhibition><synaptic inhibition><synthetic drug><synthetic opiate><synthetic opioid><temporal measurement><temporal resolution><therapeutic agent development><therapeutic development><time measurement><ventral tegmentum><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR>

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Sara Saavedra

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$46,395

FY 2026

Project Title

Exploration of the unique neurobehavioral profile of sequential opioid-stimulant polysubstance use disorders

Grant Number:

5F31DA059262-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Among drug users, polysubstance use is much more common than single substance use. One of the deadliest combinations of substances used in America today is concurrent opioid and stimulant usage, with co-use of these drugs becoming increasingly responsible for overdose deaths. Out of the 2.1 million ...

Research Terms

<3-D><3-Dimensional><3D><Actiq><American><Animals><Assay><Autopsy><Behavior><Behavioral><Bioassay><Biological Assay><Body Tissues><Brain><Brain Nervous System><CNS plasticity><Chronic><Common Rat Strains><Coon's Technic><Coon's Technique><Crystal Meth><Crystal methamphetamine><Cues><Decision Making><Deoxyephedrine><Desoxyephedrine><Development><Disease><Disorder><Drug Combinations><Drug Modelings><Drug Therapy><Drug usage><Drug user><Drugs><Duragesic><Encephalon><Exposure to><Extinction><FBJ osteosarcoma oncogene><FOS gene><Fentanest><Fentanyl><Fentyl><Fluorescent Antibody Technic><Fluorescent Antibody Technique><Fluorescent Antinuclear Antibody Test><G0S7><Ganglia><Gene Transfer><Goals><History><Human><IV Infusion><Image><Immunofluorescence Technic><Immunofluorescence Technique><Individual><Intravenous infusion procedures><Learning><Light><METH use><Maps><Mediating><Medication><Methamphetamine><Methamphetamine use disorder><Methylamphetamine><Microscopy><Modeling><Modern Man><Molecular><Motivation><N-Methylamphetamine><Nerve Cells><Nerve Transmitter Substances><Nerve Unit><Nervous System><Neural Cell><Neural Ganglion><Neurobiology><Neurocyte><Neurologic Body System><Neurologic Organ System><Neuronal Plasticity><Neurons><Neurotransmitters><Opiates><Opioid><PWUD><Pattern><Pharmaceutical Preparations><Pharmacologic Actions><Pharmacological Treatment><Pharmacotherapy><Phentanyl><Photoradiation><Prevalence><Prevention><Probability><Protooncogene FOS><R-Series Research Projects><R01 Mechanism><R01 Program><Rat><Rats Mammals><Rattus><Receptor Protein><Recording of previous events><Research><Research Grants><Research Project Grants><Research Projects><Rewards><Rodent><Rodent Model><Rodentia><Rodents Mammals><Self Administered><Self Administration><Stimulant><Substance Addiction><Substance Dependence><Substance Use Disorder><System><Testing><Thalamic structure><Thalamus><Time><Tissues><Treatment outcome><Viral><activity marker><addiction><addictive disorder><behavior phenotype><behavior test><behavioral economics><behavioral phenotyping><behavioral test><c fos><c-fos Gene><c-fos Proto-Oncogenes><central nervous system plasticity><cue reactivity><developmental><drug abstinence><drug intervention><drug relapse><drug seeking behavior><drug treatment><drug use><drug/agent><effective therapy><effective treatment><fentanyl seeking><fluorescent antibody><histories><imaging><insight><interest><intravenous infusion><meth><meth use disorder><methamphetamine use><multidrug use><multiple drug use><multiple substance use><multisubstance use><necropsy><neural><neural circuit><neural circuitry><neural plasticity><neurobehavioral><neurobiological><neurocircuitry><neuronal><neuroplastic><neuroplasticity><novel><opiate consumption><opiate drug use><opiate intake><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid intake><opioid use><opioid use disorder><overdose death><overdose fatalities><people who use drugs><people who use illicit drugs><persons who use drugs><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><poly drug use><poly substance use><polydrug use><polysubstance use><postmortem><psychostimulant use><receptor><recruit><response><reward processing><stimulant use><substance use><substance use and disorder><substance using><synaptic circuit><synaptic circuitry><thalamic><three dimensional><use of stimulants><v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog>

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Jessica Tierney

UNIVERSITY OF TEXAS MED BR GALVESTON, GALVESTON, TX

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$39,615

FY 2026

Project Title

Mechanisms of prenatal opioid exposure on offspring brain development and behavior

Grant Number:

1F30DA065327-01

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2030

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT The estimated rate of maternal opioid-related diagnoses of opioid use disorder (OUD) increased 131% from 2010 to 2017. Human clinical data show an association between maternal OUD and neuropsychiatric disorder diagnoses in children. Managing pregnant OUD patients is challeng...

Research Terms

<0-11 years old><12-20 years old><AD/HD><ADHD><Adolescence><Affect><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Animals><Anxiety><Assay><Attention deficit hyperactivity disorder><Automobile Driving><Behavior><Behavioral><Behavioral Assay><Bioassay><Biological Assay><Brain><Brain Nervous System><Brain region><Buprenorphine><Calcium><Cell Body><Cells><Child><Child Health><Child Youth><Children (0-21)><Clinical><Clinical Data><Complex><Control Groups><Data><Defect><Development><Diagnosis><Differences between sexes><Differs between sexes><Dihydrohydroxycodeinone><Dose><Drugs><Embryo><Embryonic><Encephalon><Equilibrium><Exhibits><FDA approved><Fetal Distress><Fiber><Future><Gestation><Goals><Health Care Providers><Health Personnel><Human><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><Infant><Lateral><Learning><Link><Medial><Medication><Memory><Mental Depression><Mice><Mice Mammals><Miscarriage><Modeling><Modern Man><Molecular><Murine><Mus><Neonatal Abstinence Syndrome><Neonatal Opioid Withdrawal Syndrome><Neonatal Substance Withdrawal><Neonatal Withdrawal Syndrome><Opiate Receptors><Opiates><Opioid><Opioid Receptor><Outcome><Outcome Study><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Patients><Pharmaceutical Preparations><Phenotype><Photometry><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prefrontal Cortex><Pregnancy><Premature Labor><Premature Obstetric Labor><Preterm Labor><Process><Proteins><Ramp><Recommendation><Research><Risk><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><Roxicodone><Saccharose><Sex Differences><Sexual differences><Signal Pathway><Social Interaction><Spontaneous abortion><Sucrose><Symptoms><Testing><Therapeutic><Therapeutic Intervention><Time><Transcript><Transcription Alteration><Work><adolescence (12-20)><adverse consequence><adverse maternal outcomes><adverse outcome><amygdaloid nuclear complex><arm><balance><balance function><clinical relevance><clinically relevant><cohort><conditioned fear><depression><developmental><developmental disease><developmental disorder><driving><drug/agent><early adulthood><emerging adult><fear conditioning><fetal opiate exposures><fetal opioid exposure><gestational opiate exposure><gestational opioid exposure><gestational opioid use><health care personnel><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><in utero><insight><intervention therapy><kids><male><maternal opiates use><maternal opioid use><medical care providers><medical personnel><medication for opioid use disorder><memory recognition><mouse model><murine model><neural><neurogenesis><neuropsychiatric><neuropsychiatric disease><neuropsychiatric disorder><neuropsychiatry><newborn abstinence syndrome><non-medical opioid use><nonmedical opioid use><novel><offspring><opiate consumption><opiate drug use><opiate exposure><opiate intake><opiate misuse><opiate use><opiate use disorder><opiate use in pregnancy><opioid consumption><opioid drug use><opioid exposure><opioid intake><opioid misuse><opioid use><opioid use disorder><opioid use in pregnancy><opioids during pregnancy><opioids in pregnancy><opoid use during pregnancy><postnatal><preference><pregnant><prenatal opiate exposure><prenatal opioid exposure><prenatal opioid use><prenatally opiate exposed><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><side effect><social role><spatial RNA sequencing><spatial and temporal><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial temporal><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><spatiotemporal><treatment provider><youngster><♂>

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Samantha Speyer Dunn

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$39,339

FY 2026

Project Title

Investigating the role of locus coeruleus mu opioid receptors in fentanyl drug seeking

Grant Number:

1F31DA065440-01

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Opioid addiction results in the death of tens of thousands of individuals in the U.S. every year. That number is only continuing to grow. A large reason for the growing number of opioid-related deaths is the introduction and mass production of synthetic opioids like fentanyl...

Research Terms

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Riley Shearer

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$35,027

FY 2026

Project Title

Characteristics and outcomes for hospitalized patients with methamphetamine and opioid co-use: Identifying opportunities for hospital-based addiction services tailored to co-use

Grant Number:

5F30DA057775-04

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/28/2027

Why this may be worth a closer look

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Project Abstract

PROJECT SUMMARY/ABSTRACT Drug overdose deaths continue to rise in the United States, accounting for over 100,000 deaths in 2021 alone. Methamphetamine and opioid co-use are largely fueling the most recent increase in mortality. In addition, co- use associated hospital admissions increased more than ...

Research Terms

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Landon Bayless-Edwards

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$33,420

FY 2026

Project Title

Intracellular signaling mechanisms underlying opioid modulation of pain

Grant Number:

5F30DA057838-04

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2023

End Date:

7/31/2026

Why this may be worth a closer look

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Project Abstract

PROJECT SUMMARY Opioid use disorder is a public health crisis that stems from the highly addictive nature and potent analgesic properties of opioids. Opioids modulate circuitry involved in analgesia, pain-induced negative affect, motivation, reward, and addiction. They act on G-protein coupled opioi...

Research Terms

<2-photon><3'5'-cyclic ester of AMP><3,5 cyclic AMP synthetase><Absence of pain sensation><Absence of sensibility to pain><Acute><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine Cyclic Monophosphate-Dependent Protein Kinases><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adenyl Cyclase><Adenylate Cyclase><Adenylyl Cyclase><Affect><Affective><Agonist><Analgesia Tests><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Anterior><Antinociceptive Agents><Antinociceptive Drugs><Behavior><Behavioral Assay><Brain region><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chronic><Complex><Connector Neuron><Coupled><Cyclic AMP><Cyclic AMP-Dependent Protein Kinases><Dendrites><FISH Technic><FISH Technique><FISH analysis><FISH assay><FLIM imaging><FRET><Feels no pain><Fluorescence In Situ Hybridization><Fluorescence Resonance Energy Transfer><Fluorescent in Situ Hybridization><Förster Resonance Energy Transfer><G-Proteins><GTP-Binding Proteins><GTP-Regulatory Proteins><Goals><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><Hour><Hyperalgesia><Hyperalgesic Sensations><Image><In Vitro><Infumorph><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><Kadian><Label><MS Contin><MSir><Measures><Mediating><Membrane><Methodology><Mice><Mice Mammals><Modeling><Morphia><Morphine><Motivation><Murine><Mus><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><No sensitivity to pain><Nociception Tests><Opiate Receptors><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid Receptor><Opioid agonist><Opioid receptor agonist><Oramorph><Oramorph SR><PKA><Pain><Pain Assessment><Pain Measurement><Pain measure><Painful><Pathway interactions><Peptides><Play><Position><Positioning Attribute><Production><Property><Protein Dynamics><Protein Kinase A><Protein Kinase A Inhibitor><Public Health><Pyramidal neuron><Receptor Activation><Receptor Protein><Regulation><Research><Resolution><Rewards><Role><Roxanol><Sensory><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Site><Specificity><Statex SR><Synapses><Synaptic><Testing><Thalamic structure><Thalamus><Work><addiction><addictive disorder><adenosine 3'5' monophosphate><analgesia><antagonism><antagonist><behavior study><behavioral study><biological signal transduction><brain cell><cAMP><cAMP-Dependent Protein Kinases><cell type><cingulate cortex><dermorphin><design><designing><experiment><experimental research><experimental study><experiments><fluorescence life-time imaging><fluorescence life-time imaging microscopy><fluorescence lifetime imaging><fluorescence lifetime imaging microscopy><hippocampal pyramidal neuron><hyperalgia><imaging><imaging in vivo><in vivo><in vivo imaging><insight><interest><membrane structure><morphine administration><mu opioid receptors><negative affect><negative affectivity><neural cell body><neuronal><neuronal cell body><novel><opiate exposure><opiate use disorder><opioid exposure><opioid use disorder><pain assay><pain behavior><pain killer><pain medication><pain relief><pain reliever><painkiller><pathway><photoactivation><receptor><receptor expression><regional difference><relieve pain><resolutions><response><sensor><sensory integration><social role><soma><spatial and temporal><spatial temporal><spatiotemporal><stem><synapse><thalamic><two-photon><μ opioid receptors><μ-OR><μOR>

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SUZANNAH K CREECH

UNIVERSITY OF TEXAS AT AUSTIN, AUSTIN, TX

Exploratory lead · 34/100

Above-average budget

Active award

$721,095

FY 2026

Project Title

Testing an occupational stress intervention for harm reduction workers in substance misuse settings

Grant Number:

4R33DA059887-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2023

End Date:

11/30/2029

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

This study is part of the NIH’s Helping to End Addiction Long-term (HEAL) initiative to speed scientific solutions for the overdose epidemic, including opioid and stimulant use disorders. The NIH HEAL Initiative bolsters research across NIH to address the national opioid public health crisis and imp...

Research Terms

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Erin F Madden

LOYOLA UNIVERSITY CHICAGO, MAYWOOD, IL

Exploratory lead · 34/100

Above-average budget

Active award

$633,110

FY 2026

Project Title

Leveraging CDC Opioid Overdose Surveillance Funding from the Albuquerque Area Southwest Tribal Epidemiology Center to Create Tribal Data and Culturally Center Medications for Opioid Use Disorder

Grant Number:

5R33DA049382-05

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/22/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Fatal opioid overdose rates are higher among American Indian/Alaska Native populations than among Hispanics, African Americans, and Asian Americans, and are just below non-Hispanic Whites. AI/AN opioid overdose rates vary significantly by state and county; however, tribe-lev...

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Fares Qeadan

LOYOLA UNIVERSITY CHICAGO, MAYWOOD, IL

Exploratory lead · 34/100

Above-average budget

Active award

$633,110

FY 2026

Project Title

Leveraging CDC Opioid Overdose Surveillance Funding from the Albuquerque Area Southwest Tribal Epidemiology Center to Create Tribal Data and Culturally Center Medications for Opioid Use Disorder

Grant Number:

5R33DA049382-05

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/22/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Fatal opioid overdose rates are higher among American Indian/Alaska Native populations than among Hispanics, African Americans, and Asian Americans, and are just below non-Hispanic Whites. AI/AN opioid overdose rates vary significantly by state and county; however, tribe-lev...

Research Terms

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Kamilla L. Venner

LOYOLA UNIVERSITY CHICAGO, MAYWOOD, IL

Exploratory lead · 34/100

Above-average budget

Active award

$633,110

FY 2026

Project Title

Leveraging CDC Opioid Overdose Surveillance Funding from the Albuquerque Area Southwest Tribal Epidemiology Center to Create Tribal Data and Culturally Center Medications for Opioid Use Disorder

Grant Number:

5R33DA049382-05

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/22/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Fatal opioid overdose rates are higher among American Indian/Alaska Native populations than among Hispanics, African Americans, and Asian Americans, and are just below non-Hispanic Whites. AI/AN opioid overdose rates vary significantly by state and county; however, tribe-lev...

Research Terms

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May Hui

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 34/100

Training-friendly

Active award

$55,114

FY 2026

Project Title

Investigation of neural ensembles underlying chronic pain

Grant Number:

5F30DA056215-04

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

11/12/2022

End Date:

11/11/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Chronic pain affects nearly 1 in every 5 adults worldwide 1, posing a major public health concern and economic burden. Yet, despite the widespread prevalence of chronic pain, few effective strategies for long-term pain management exist. Historically, physicians have relied upon a coc...

Research Terms

<21+ years old><5-HT><5-Hydroxytryptamine><5HT><Acute><Acute Pain><Acute pain management><Acutely painful><Adult><Adult Human><Affect><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Analgesia Tests><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Animals><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Area><Axon Terminals><Brain><Brain Nervous System><Brain imaging><Brain region><Caring><Cell Body><Cells><Chromosome Mapping><DNA Recombination><DREADDs><Dependence><Development><Dose><Dysfunction><Economic Burden><Elements><Encephalon><Enteramine><Epidemic><FBJ osteosarcoma oncogene><FOS gene><Functional disorder><G0S7><Gene Localization><Gene Mapping><Gene Mapping Genetics><Genetic><Genetic Recombination><Hippophaine><Human><Image><Immediate-Early Genes><Injury><Investigation><Label><Levarterenol><Levonorepinephrine><Light><Linkage Mapping><Literature><Long-Term Effects><Long-term pain><Maps><Mediating><Medical><Medulla Spinalis><Methods><Mice><Mice Mammals><Microbeads><Microscopy><Microspheres><Modern Man><Molecular Fingerprinting><Molecular Profiling><Murine><Mus><Negative Valence><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nociception><Nociception Tests><Noradrenaline><Norepinephrine><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Pain><Pain Assessment><Pain Control><Pain Map><Pain Measurement><Pain Therapy><Pain management><Pain measure><Painful><Pathway interactions><Patients><Perioperative><Peripheral Nervous System><Persistent pain><Photoradiation><Physicians><Physiopathology><Population><Positive Valence><Presynaptic Nerve Endings><Presynaptic Terminals><Prevalence><Protooncogene FOS><Public Health><Rabies><Rabies lyssavirus><Rabies mapping><Rabies trans synaptic tracing><Rabies virus><Rabies virus mediated mapping><Recombination><Resolution><Rewards><Risk><Sensory><Serotonin><Spinal Cord><Stimulus><Structure><Surgical><Surgical Interventions><Surgical Procedure><Synaptic Boutons><Synaptic Terminals><Testing><Time><Total Human and Non-Human Gene Mapping><Tricyclic Antidepressant Drugs><Tricyclic Antidepressants><Tricyclic Antidepressive Agents><United States><Work><acute to chronic pain transition><adulthood><amygdaloid nuclear complex><brain visualization><c fos><c-fos Gene><c-fos Proto-Oncogenes><cell type><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain patient><chronic pain therapy><chronic pain transition><chronic pain treatment><chronic symptom><combat><constant pain><designer receptors exclusively activated by designer drugs><developmental><genetic mapping><human imaging><image-based method><imaging><imaging method><imaging modality><imaging study><inhibitor><injuries><innovate><innovation><innovative><interest><labeled by a rabies virus><labeled with rabies><lasting pain><licit opioid><longitudinal imaging><lyssa><molecular profile><molecular signature><neural><neural circuit><neural circuitry><neural mechanism><neurocircuitry><neuromechanism><neuronal><nociceptive><non-medical opioid use><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonmedical opioid use><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><on-going pain><ongoing pain><opiate abuse><opiate consumption><opiate crisis><opiate deaths><opiate drug abuse><opiate drug use><opiate intake><opiate medication><opiate misuse><opiate mortality><opiate overdose><opiate related overdose><opiate use><opioid abuse><opioid consumption><opioid crisis><opioid deaths><opioid drug abuse><opioid drug overdose><opioid drug use><opioid epidemic><opioid induced overdose><opioid intake><opioid intoxication><opioid medication><opioid medication overdose><opioid misuse><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid toxicity><opioid use><pain assay><pain behavior><pain chronification><pain intervention><pain killer><pain medication><pain reliever><pain sensitivity><pain treatment><painkiller><pathophysiology><pathway><patient with chronic pain><persistent symptom><pharmacologic><premonitory sensory phenomena><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><prevent><preventing><rabies based mapping><rabies based retrograde mapping><rabies circuit tracing><rabies label><rabies mediated retrograde monosynaptic tracing><rabies retrograde tracing><rabies tracer><rabies tracing><rabies viral tracing><rabies virus label><rabies virus labeling><rabies virus mediated cellular labeling><rabies virus mediated circuit mapping><rabies virus monosynaptic circuit tracing><rabies virus monosynaptic tracing><rabies virus neurotracer><rabies virus retrograde tracing><rabies virus to label><rabies virus tracing><resolutions><reuptake><sciatic nerve injury><sensory phenomena><serial imaging><somatosensory><spatial and temporal><spatial temporal><spatiotemporal><standard of care><surgery><synaptic circuit><synaptic circuitry><tracing with rabies><transition to chronic pain><treat chronic pain><v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog>

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Dez Coleman

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 34/100

Training-friendly

Active award

$50,114

FY 2026

Project Title

Genetic Characterization and Exploration of Mu-Opioid Receptor Signaling in C. elegans

Grant Number:

5F31DA062403-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/16/2024

End Date:

12/15/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Opioids are the most effective pharmacological treatment for pain but feature severe negative side effects including tolerance and abuse liability, highlighting the need for strategies to make opioid drugs safer. The key molecular target modulating opioid analgesia and probl...

Research Terms

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Emma Elyse Tyner

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 34/100

Training-friendly

Active award

$50,114

FY 2026

Project Title

Identifying a role for the mu-opioid receptor in the paraventricular nucleus of the thalamus in the development of stress related phenotypes

Grant Number:

5F31DA062541-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Stress and stressful environments often lead to maladaptive behaviors that can increase vulnerability to substance use disorders. The paraventricular nucleus of the thalamus (PVT) has been implicated in both stress and drug reward with a population of mu-opioid receptor-expr...

Research Terms

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Corinna Oswell

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 34/100

Training-friendly

Active award

$50,114

FY 2026

Project Title

Endogenous opioid modulation of cortical pain circuits.

Grant Number:

5F31DA062445-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Chronic pain is a pervasive burden affecting over 50 million US citizens. The experience of pain is subject to modulation based on context; however, the mechanism of this modulation is unknown. This project aims to unravel the intricate dynamics of prefrontal cortical microc...

Research Terms

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Monica H Dawes

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Exploratory lead · 34/100

Training-friendly

Active award

$50,114

FY 2026

Project Title

Characterization of Polysubstance Use: Combined Fentanyl and Methamphetamine

Grant Number:

5F31DA057815-04

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary The opioid epidemic currently affecting the United States has entered a new wave of mortality, with combined use of opioid and psychomotor simulants as a major contributing factor to the number of overdose deaths. Combined use of fentanyl and methamphetamine may be due to a number of...

Research Terms

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Francesca LoFaro

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 34/100

Training-friendly

Active award

$48,357

FY 2026

Project Title

Elucidating How Menstrual Cycle Phase Influences Neurocognitive Processes Underlying Risk-Taking in Women with Opioid Use Disorder

Grant Number:

5F31DA061610-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

11/5/2024

End Date:

11/4/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Women have been underrepresented in neuroimaging studies of opioid use disorder (OUD) and even fewer neuroimaging studies have targeted female-specific health factors, such as the menstrual cycle. This is concerning because women have disproportionately higher rates of relap...

Research Terms

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Jessica McInerney

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Exploratory lead · 34/100

Training-friendly

Active award

$47,104

FY 2026

Project Title

The Impact of Perinatal Fentanyl on Dopamine Neuron Circuitry and Behavior

Grant Number:

5F31DA062453-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/12/2024

End Date:

12/11/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Use of illicit substances has reached endemic levels in the United States with over 91,000 deaths due to drug overdose occurring in 2020. This has largely affected women of childbearing age as opioid use disorder has more than quadrupled among pregnant women in the past 20 years. Bot...

Research Terms

<0-4 weeks old><21+ years old><Actiq><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Anhedonia><Attenuated><Automobile Driving><Axon><Basal Transcription Factor><Basal transcription factor genes><Behavior><Behavioral><Biosensor><Body Tissues><Brain><Brain Nervous System><Brain region><Breeding><Cell Communication and Signaling><Cell Signaling><Cessation of life><Chronic><Clinical Research><Clinical Study><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Conceptions><Cues><DA Neuron><Data><Death><Development><Developmental Delay><Developmental Delay Disorders><Differential Gene Expression><Disturbance in cognition><Dopamine><Dopamine neuron><Down-Regulation><Drugs><Duragesic><Encephalon><Exhibits><Exposure to><Female of child bearing age><Female of childbearing age><Fentanest><Fentanyl><Fentyl><Fiber><Fiber Optics><Food><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Transcription><Gestation><Hospital Charges><Hydrogen Oxide><Hydroxytyramine><Impaired cognition><Implant><Incidence><Infant><Injections><Intracellular Communication and Signaling><Lab Findings><Laboratory Finding><Learning><Length><Link><Long-Term Effects><Maintenance><Measures><Medication><Mice><Mice Mammals><Molecular><Morphology><Mothers><Motivation><Murine><Mus><Neonatal Abstinence Syndrome><Neonatal Opioid Withdrawal Syndrome><Neonatal Substance Withdrawal><Neonatal Withdrawal Syndrome><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Newborn Infant><Newborns><Nucleus Accumbens><Opiates><Opioid><Output><Overdose><Pathway interactions><Perinatal><Perinatal Exposure><Peripartum><Pharmaceutical Preparations><Phentanyl><Photometry><Population><Pregnancy><Pregnant Women><Process><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Recovery><Research><Retrieval><Rewards><Saccharose><Schedule><Self Administered><Self Administration><Signal Transduction><Signal Transduction Systems><Signaling><Specific Child Development Disorders><Specificity><Sucrose><Testing><Time><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Tissues><Transcript><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><United States><Ventral Tegmental Area><Water><Weaning><Woman><adulthood><attenuate><attenuates><axon growth cone guidance><axon guidance><bear children><bearing children><biological sensor><biological signal transduction><child bearing><childbearing><cognitive dysfunction><cognitive loss><compare to control><comparison control><developmental><differential expression><differentially expressed><dopaminergic neuron><drinking water><driving><drug/agent><expectant mother><expectant women><expecting mother><expecting women><experiment><experimental research><experimental study><experiments><exposed in utero><fentanyl exposure><fetal exposure><in utero><in utero exposure><individuals who are pregnant><intra-uterine environmental exposure><intrauterine environmental exposure><juvenile><juvenile human><mesolimbic dopamine system><mesolimbic system><motivated behavior><neural adaptation><neural cell body><neuroadaptation><neuron development><neuronal><neuronal cell body><neuronal circuit><neuronal circuitry><neuronal development><newborn abstinence syndrome><newborn child><newborn children><offspring><opiate consumption><opiate drug use><opiate exposure><opiate intake><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid exposure><opioid intake><opioid use><opioid use disorder><pathway><people who are pregnant><post-natal period><postnatal period><pre-clinical study><preclinical study><pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal exposure><prenatally exposed><receptor><response><reward circuitry><reward processing><soma><synthetic opiate><synthetic opioid><those who are pregnant><transcription factor><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><ventral tegmentum><women of child bearing age><women of childbearing age><women who are pregnant>

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Pryce Michener

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Exploratory lead · 34/100

Training-friendly

Active award

$34,114

FY 2026

Project Title

Implementation of Medications for Opioid Use Disorder in Massachusetts Jails

Grant Number:

5F30DA058525-03

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary: Opioid overdose deaths and other substance-related mortality remain at an all-time high in the United States, and evidence suggests that mortality will continue to worsen without significant changes to the landscape of opioid use disorder (OUD) treatment. Overdose mortality is the l...

Research Terms

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Karen J. Hartwell

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Exploratory lead · 32/100

Solid budget

Recent

Active award

$453,000

FY 2026

Project Title

Empowering EMPATH Units: Training for Intergrated Mental Health and Opioid Disorder Management

Grant Number:

1R61DA065218-01

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2028

Project Abstract

PROJECT ABSTRACT Emergency departments (EDs) face significant challenges managing mental health crises, often lacking specialized resources and leading to inappropriate placements and insufficient follow-up care. Emergency Psychiatric Assessment, Treatment, and Healing (EmPATH) units are designed to...

Research Terms

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Lindsey K Jennings

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Exploratory lead · 32/100

Solid budget

Recent

Active award

$453,000

FY 2026

Project Title

Empowering EMPATH Units: Training for Intergrated Mental Health and Opioid Disorder Management

Grant Number:

1R61DA065218-01

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2028

Project Abstract

PROJECT ABSTRACT Emergency departments (EDs) face significant challenges managing mental health crises, often lacking specialized resources and leading to inappropriate placements and insufficient follow-up care. Emergency Psychiatric Assessment, Treatment, and Healing (EmPATH) units are designed to...

Research Terms

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Md Mahmudul Hasan

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 32/100

Solid budget

Recent

Active award

$439,826

FY 2026

Project Title

Developing and Evaluating a Machine-Learning Buprenorphine Care Discontinuity Prediction E-Tool (BUP-CARE)

Grant Number:

1R21DA062834-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2028

Project Abstract

Project Summary Over 81,000 Americans died from opioid overdose in 2023. Opioid overdose and opioid use disorder (OUD) impose significant societal and economic burdens, making sustained OUD treatment a critical public health priority. Buprenorphine, an evidence-based therapy for OUD, reduces overdos...

Research Terms

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Wei-Hsuan Jenny Lo-Ciganic

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 32/100

Solid budget

Recent

Active award

$439,826

FY 2026

Project Title

Developing and Evaluating a Machine-Learning Buprenorphine Care Discontinuity Prediction E-Tool (BUP-CARE)

Grant Number:

1R21DA062834-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2028

Project Abstract

Project Summary Over 81,000 Americans died from opioid overdose in 2023. Opioid overdose and opioid use disorder (OUD) impose significant societal and economic burdens, making sustained OUD treatment a critical public health priority. Buprenorphine, an evidence-based therapy for OUD, reduces overdos...

Research Terms

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Rodrigo A. España

DREXEL UNIVERSITY, PHILADELPHIA, PA

Exploratory lead · 32/100

Solid budget

Recent

Active award

$416,066

FY 2026

Project Title

Novel Circuit Mechanism for Opioid-Induced Dopamine Elevations: Beyond Midbrain Dopamine Neuron Activity

Grant Number:

1R21DA065334-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/29/2028

Project Abstract

Project Summary/Abstract: Opioid use disorder is a major public health crisis with widespread socioeconomic consequences. Most drugs of abuse, including opioids, increase dopamine levels in the nucleus accumbens, and disruption of nucleus accumbens dopamine signaling reduces opioid seeking behavior....

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><ACh Receptors><Acetylcholine><Acetylcholine Receptors><Aminalon><Aminalone><Anatomic Sites><Anatomic structures><Anatomy><Behavior><Behavior assessment><Behavioral><Brain><Brain Nervous System><Brain region><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cholinergic Receptors><Cholinoceptive Sites><Cholinoceptors><Connector Neuron><Coupled><Cyclicity><DA Neuron><Development><Dihydrohydroxycodeinone><Disinhibition><Dopamine><Dopamine neuron><Drugs><Electrophysiology><Electrophysiology (science)><Encephalon><Exclusion><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Foundations><Future><GABA><GABA Receptor><Histology><Hydroxytyramine><Individual><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><Knowledge><Measures><Medication><Mesencephalon><Messenger RNA><Mid-brain><Midbrain><Midbrain structure><Molecular><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nicotinic Acetylcholine Receptors><Nicotinic Receptors><Nucleus><Nucleus Accumbens><Opiates><Opioid><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Periodicity><Pharmaceutical Preparations><Population><Process><Psychological reinforcement><Public Health><Receptor Inhibition><Reinforcement><Reporting><Rhythmicity><Role><Roxicodone><Scanning><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Transmission><Ventral Tegmental Area><Viral><Viral Genes><Virus><abused drug><abused drugs><alternative treatment><behavioral assessment><biological signal transduction><biomarker identification><cell type><cholinergic><developmental><dopaminergic neuron><drug abused><drug of abuse><drug/agent><drugs abused><drugs of abuse><effective therapy><effective treatment><electrophysiological><experiment><experimental research><experimental study><experiments><extracellular><gamma-Aminobutyric Acid><gamma-Aminobutyric Acid Receptors><health care burden><identification of biomarkers><identification of new biomarkers><in vivo><insight><knock-down><knockdown><mRNA><marker identification><mu opioid receptors><neural circuit><neural circuitry><neurobiological mechanism><neurochemical><neurochemistry><neurocircuitry><neuronal><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><novel virus><opiate use disorder><opioid use disorder><overdose death><overdose fatalities><pharmacologic><prevent><preventing><receptor expression><receptor function><shRNA><short hairpin RNA><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><synaptic circuit><synaptic circuitry><therapeutic agent development><therapeutic development><tool><transmission process><uptake><ventral tegmentum><γ-Aminobutyric Acid><μ opioid receptors><μ-OR><μOR>

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Megan Reed

THOMAS JEFFERSON UNIVERSITY, PHILADELPHIA, PA

Exploratory lead · 32/100

Solid budget

Recent

Active award

$346,500

FY 2026

Project Title

Xylazine, Pregnancy, and Access to Care

Grant Number:

1R21DA065026-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2028

Project Abstract

PROJECT ABSTRACT In the past decade, the animal tranquilizer xylazine has been rapidly spreading across the United States, with all four census regions reporting a rise between 2020 and 2021. Although xylazine prevalence and related overdoses remain primarily concentrated in the Northeast U.S., othe...

Research Terms

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Kristen Addie McLaurin

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Exploratory lead · 30/100

Very recent

Active award

$249,000

FY 2026

Project Title

Neurocognitive Impairments Resulting from Adolescent Prescription Opioid Use Disorder: Longitudinal Impact, Neural Mechanisms, and Comorbidities

Grant Number:

5R00DA056288-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT The goals of the proposed K99 career training plan include: 1) gaining expertise and research experience in substance use disorders (SUD), addictive processes, and opioid pharmacology; 2) mastering stereotaxic sur- geries, adeno-associated virus gene delivery, and in vivo fi...

Research Terms

<12-20 years old><21+ years old><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adeno-Associated Viruses><Adolescence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adult><Adult Human><Advisory Committees><Age Years><Agonist><Biosensor><Brain><Brain Nervous System><Cell Body><Cells><Chronic><Clinical><Common Rat Strains><Communicable Diseases><Control Animal><DREADDs><Dependence><Dependoparvovirus><Dependovirus><Development><Developmental Process><Dihydrohydroxycodeinone><Dopamine><Dose><Dysfunction><Encephalon><Environment><Episodic memory><Evaluation><Experimental Designs><Exposure to><Faculty><Female><Fiber><Foundations><Functional disorder><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Gene Delivery><Goals><HIV><HIV Infections><HIV viral infection><HIV virus infection><HIV-1><HIV-1 infection><HIV-I><HIV1><Hour><Human><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Hydrogen Oxide><Hydroxytyramine><IQ Deficit><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Infectious Diseases><Infectious Disorder><Institution><Intake><International><LAV-HTLV-III><Laboratories><Lymphadenopathy-Associated Virus><Mentors><Modeling><Modern Man><Muscarinic Agents><Muscarinics><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Neurocognitive><Neurocognitive Deficit><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Oral><Overdose><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Pharmacology><Phase><Photometry><Physiopathology><Prefrontal Cortex><Process><Public Health><Rat><Rats Mammals><Rattus><Research><Role><Roxicodone><SAMHSA><Saline><Saline Solution><Scientist><South Carolina><Strategic Planning><Substance Abuse and Mental Health Services Administration><Substance Use Disorder><Surgical><Surgical Interventions><Surgical Procedure><Synapses><Synaptic><System><Task Forces><Testing><Training><United States Substance Abuse and Mental Health Services Administration><Universities><Ventral Tegmental Area><Viral Gene Products><Viral Gene Proteins><Viral Proteins><Virus-HIV><Water><adeno associated virus group><adolescence (12-20)><adult youth><adulthood><advisory team><biological sensor><biological sex><biological systems><career><career development><co-morbid><co-morbidity><cognitive process><comorbidity><critical developmental period><designer receptors exclusively activated by designer drugs><developmental><dopamine system><experience><experiment><experimental research><experimental study><experiments><exposure route><high risk group><high risk individual><high risk people><high risk population><human immunodeficiency virus infection><in vivo><infected with HIV><infected with human immunodeficiency virus><intelligence quotient deficit><juvenile><juvenile human><licit opioid><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><male><neural mechanism><neurocognitive decline><neurocognitive impairment><neuromechanism><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><opiate abuse><opiate crisis><opiate drug abuse><opiate medication><opiate use disorder><opioid abuse><opioid crisis><opioid drug abuse><opioid epidemic><opioid medication><opioid use disorder><oxycodone self-administration><pathophysiology><postnatal><pre-clinical><preclinical><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><self-administer oxycodone><skills><social role><substance use><substance use and disorder><substance using><surgery><sustained attention><synapse><therapeutic target><ventral tegmentum><virus protein><young adult><young adult age><young adulthood><♀><♂>

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Chung Jung Mun

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS, SCOTTSDALE, AZ

Exploratory lead · 30/100

Very recent

Active award

$235,500

FY 2026

Project Title

Investigating the Feasibility of Combining Mindfulness Intervention and Open-Label Placebo Treatment for Chronic Pain

Grant Number:

5R34AT012677-03

Activity Code:

R34

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/26/2024

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: Chronic pain affects over one third of the U.S. population and is a leading cause of disability. Hence, there is pressing need for developing innovative, safe, and accessible non-opioid treatments that effectively alleviate chronic pain. Mindfulness-based therapies (MBTs) have emerg...

Research Terms

<21+ years old><Absence of pain sensation><Absence of sensibility to pain><Active Follow-up><Acute Pain><Acutely painful><Adherence><Adult><Adult Human><Affect><After Care><After-Treatment><Aftercare><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Attention><Awareness><Biochemical><Cardiovascular Diseases><Caring><Chronic Disease><Chronic Illness><Clinical><Clinical Trials><Consumption><Dairying><Data><Deception><Detection><Development><Diabetes Mellitus><Effectiveness of Interventions><Ethical Issues><Ethics><Evaluation><Feasibility Studies><Feels no pain><Foundations><Frequencies><Future><Goals><Grant><Guidelines><Individual><Intervention><Length><Measures><Mediating><Meta-Analysis><Mind-Body Intervention><Mind-Body Medicine><Mindfulness Approach><Mindfulness Therapy><Mindfulness Training><Mindfulness Treatment><Mindfulness-based Approach><Mindfulness-based Therapy><Mindfulness-based Training><Mindfulness-based Treatment><Monitor><Multi-Institutional Clinical Trial><Multi-center clinical trial><Multi-site clinical trial><Multicenter clinical trial><Multisite clinical trial><No sensitivity to pain><Outcome><Pain><Pain interference><Painful><Participant><Patient Recruitments><Patient Self-Report><Patients><Placebos><Play><Population><Postoperative><Postoperative Period><Procedures><Public Health><Randomized><Randomized, Controlled Trials><Reading><Research><Riboflavin><Risk><Safety><Self-Report><Sensory><Severities><Sham Treatment><Site><Symptoms><System><Testing><Therapeutic Effect><Tracer><Treatment Efficacy><Videoconferencing><Visit><Vitamin B 2><Vitamin B2><Vitamin G><acceptability and feasibility><active followup><adulthood><analgesia><arm><cardiovascular disorder><chronic disorder><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><clinical practice><conditioned pain modulation><design><designing><developmental><diabetes><diaries><disability><drug adherence><drug compliance><efficacy trial><endogenous opiate><endogenous opioids><ethical><feasibility testing><feasibility trial><follow up><follow-up><followed up><followup><improved><inhibit pain><innovate><innovation><innovative><insight><intervention efficacy><medication adherence><medication compliance><mind body approach><mind body medicine skills><mind body techniques><mind body therapy><mind body treatments><mind body wellness><mindfulness><mindfulness intervention><mindfulness meditation><mindfulness-based intervention><mindfulness-based stress reduction><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><open label><open label study><opiate consumption><opiate drug use><opiate intake><opiate use><opioid consumption><opioid drug use><opioid intake><opioid use><pain inhibition><pain killer><pain medication><pain outcome><pain relief><pain reliever><pain-related outcome><painkiller><participant engagement><participant enrollment><participant recruitment><participant retention><patient engagement><patient enrollment><placebo analgesia><post treatment><primary outcome><programs><randomisation><randomization><randomized control trial><randomly assigned><recruit><relieve pain><retention rate><retention strategy><satisfaction><sham therapy><side effect><statistics><therapeutic efficacy><therapy efficacy><treat chronic pain><treatment strategy><urinary><video conferencing><week trial>

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Lee Campbell

GEORGETOWN UNIVERSITY, WASHINGTON, DC

Exploratory lead · 30/100

Very recent

Active award

$195,000

FY 2026

Project Title

Probing the effect of opioids on HIV transcription and latency using a novel dual fluorescent and bioluminescent virus

Grant Number:

5R21DA063110-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Understanding the effect of opioids on Human Immunodeficiency Virus (HIV) infection is increasingly relevant in the current opioid epidemic. One in ten new HIV infections are attributed to injection drug use and people living with HIV also utilize opioids for the management of pain or in h...

Research Terms

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Italo Mocchetti

GEORGETOWN UNIVERSITY, WASHINGTON, DC

Exploratory lead · 30/100

Very recent

Active award

$195,000

FY 2026

Project Title

Probing the effect of opioids on HIV transcription and latency using a novel dual fluorescent and bioluminescent virus

Grant Number:

5R21DA063110-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Understanding the effect of opioids on Human Immunodeficiency Virus (HIV) infection is increasingly relevant in the current opioid epidemic. One in ten new HIV infections are attributed to injection drug use and people living with HIV also utilize opioids for the management of pain or in h...

Research Terms

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Shadi Nahvi

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Exploratory lead · 30/100

Recent

Active award

Career award

$194,400

FY 2026

Project Title

Mentoring investigators to improve health outcomes among persons with opioid and tobacco use disorder

Grant Number:

5K24DA051807-05

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Project Abstract

Strategies are needed to reduce the health burden of tobacco and other substance use and of overdose mortality. Few persons with substance use disorder (SUD) access treatment. To improve the delivery of evidence-based treatment of opioid-, tobacco- and other SUD, rigorous training is needed to prepa...

Research Terms

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Megan Hamm

OHIO STATE UNIVERSITY, Columbus, OH

Exploratory lead · 30/100

Recent

Active award

Career award

$192,683

FY 2026

Project Title

Mentoring the next generation of researchers at the intersection of opioid use disorder and chronic pain

Grant Number:

7K24DA056837-04

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Project Abstract

My overall goal is to improve the health and well-being of individuals with comorbid opioid misuse/opioid use disorder (OUD) and chronic pain across varied settings and populations. Research on the management of comorbid opioid misuse/OUD and chronic pain is being outpaced by the clinical need acros...

Research Terms

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Jessica S Merlin

OHIO STATE UNIVERSITY, Columbus, OH

Exploratory lead · 30/100

Recent

Active award

Career award

$192,683

FY 2026

Project Title

Mentoring the next generation of researchers at the intersection of opioid use disorder and chronic pain

Grant Number:

7K24DA056837-04

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Project Abstract

My overall goal is to improve the health and well-being of individuals with comorbid opioid misuse/opioid use disorder (OUD) and chronic pain across varied settings and populations. Research on the management of comorbid opioid misuse/OUD and chronic pain is being outpaced by the clinical need acros...

Research Terms

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Katherine Marie Serafine

UNIVERSITY OF TEXAS EL PASO, EL PASO, TX

Exploratory lead · 30/100

Very recent

Active award

$151,360

FY 2026

Project Title

The effects of eating a high fat diet on the therapeutic and abuse-related effects of morphine

Grant Number:

5R16GM149426-04

Activity Code:

R16

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. Opioid use disorder (OUD) and obesity are major comorbid public health concerns that are increasing in national prevalence. OUD contributes to approximately 68% of all...

Research Terms

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Jennifer Luz Barreto Estrada

UNIVERSITY OF PUERTO RICO MED SCIENCES, SAN JUAN, PR

Exploratory lead · 30/100

Very recent

Active award

$149,000

FY 2026

Project Title

BDNF in the Reward Circuit for DBS-Induced Opioid Extinction

Grant Number:

5R16GM149491-04

Activity Code:

R16

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract/Summary Deep brain stimulation (DBS) is a neurosurgical procedure that is used to treat neurologic and psychiatric disorders. Recent research in both animals and humans has shown that DBS may be an effective procedure for refractory addiction. We previously propose to use DBS as treatment f...

Research Terms

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Omar Koita

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 30/100

Recent

Active award

Career award

$89,739

FY 2026

Project Title

Mechanistic description of tolerance/withdrawal from opioids in the paraventricular nucleus of the thalamus

Grant Number:

5K00DA064334-04

Activity Code:

K00

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/15/2022

End Date:

2/28/2029

Project Abstract

Project Summary The paraventricular nucleus of the thalamus (PVT) is a critical node between ascending nociceptive information and goal directed behavior. Lesions, chemogenetic and optogenetic inhibition of the PVT reduces an animal’s ability to complete goal-directed behaviors. Studies have sugges...

Research Terms

<2-photon><ADRBK1><ADRBK1 gene><Actiq><Acute><Acute Pain><Acutely painful><Address><Affective Disorders><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Animals><Anodynes><Anterior><Antinociceptive Agents><Antinociceptive Drugs><Area><Awareness><BARK1><BRAIN initiative><Behavior><Behavioral Assay><Beta-ARK-1><Brain><Brain Nervous System><Brain Research through Advancing Innovative Neurotechnologies initiative><Cell Body><Cells><Chronic><Chronic stress><Clampings><Clinical><Closure by clamp><Communication><Communities><Complex><Dangerousness><Data Analyses><Data Analysis><Dedications><Dependence><Development><Dihydrocodeinone><Dihydrohydroxycodeinone><Disease><Disorder><Disparities><Disparity><Drugs><Duragesic><E-stim><Electric Stimulation><Electrophysiology><Electrophysiology (science)><Emotions><Encephalon><Environment><Experimental Designs><FBJ osteosarcoma oncogene><FOS gene><Fellowship><Fentanest><Fentanyl><Fentyl><Foundations><Funding><Future><G0S7><GRK2><Generations><Genetic><Genetic Identity><Goals><Grant><Hind Brain><Hycodan><Hycon><Hydrocodone><Hyperalgesia><Hyperalgesic Sensations><Image><Immediate-Early Genes><Infumorph><Interview><K element><Kadian><Knowledge><Label><Lead><Leanness><Lesion><Link><Locus Coeruleus><MS Contin><MSir><Manuscripts><Mediating><Medication><Mentors><Mentorship><Methods><Molecular><Monitor><Mood Disorders><Morphia><Morphine><Morphology><Motivation><Naloxone><Narcan><Narcanti><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Noci-R><Nociception><Nucleus Accumbens><Nucleus Pigmentosus Pontis><OFQ receptor><ORL1 receptor><Opiate Addiction><Opiate Dependence><Opiate Receptors><Opiates><Opioid><Opioid Receptor><Oramorph><Oramorph SR><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Paraventricular Nucleus of Thalamus><Paraventricular Thalamic Nucleus><Pattern><Pb element><Peer Review><Pharmaceutical Preparations><Phentanyl><Phosphorylation><Phosphorylation Site><Physical Dependence><Play><Postdoc><Postdoctoral Fellow><Potassium><Presynaptic Receptors><Process><Property><Protein Phosphorylation><Protooncogene FOS><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><Receptor Protein><Receptor Signaling><Research><Research Associate><Research Grants><Research Priority><Research Project Grants><Research Projects><Rewards><Rhombencephalon><Risk><Role><Roxanol><Roxicodone><Science><Scientific Publication><Scientist><Services><Shapes><Slice><Statex SR><Structure of paraventricular nucleus of thalamus><Students><Synapses><Synaptic><Synaptic plasticity><Technical Expertise><Techniques><Thalamic structure><Thalamus><Therapeutic><Therapeutic Effect><Thinness><Training><Universities><Withdrawal><Withdrawal Symptom><Work><Writing><addiction><addictive disorder><amygdaloid nuclear complex><avoidance behavior><awake><blue nucleus><c fos><c-fos Gene><c-fos Proto-Oncogenes><career><career development><channel blockers><chronic pain><collaborative approach><conference><convention><craving><data interpretation><desensitization><developmental><diversity and inclusion><diversity and inclusivity><drug seeking behavior><drug/agent><electrophysiological><electrostimulation><heavy metal Pb><heavy metal lead><hindbrain><hyperalgia><imaging><imaging in vivo><in vivo imaging><inhibitor><innovate><innovation><innovative><insight><licit opioid><locus ceruleus structure><motivated behavior><mu opioid receptors><multi-modality><multimodality><neural><neural network><neuronal><neuronal circuit><neuronal circuitry><nociceptin opioid peptide receptor><nociceptin opioid receptor><nociceptin receptor><nociceptive><opiate consumption><opiate drug use><opiate exposure><opiate intake><opiate medication><opiate overdose><opiate related overdose><opiate use><opiate use disorder><opiate withdrawal><opioid addiction><opioid consumption><opioid dependence><opioid dependent><opioid detox><opioid detoxification><opioid drug overdose><opioid drug use><opioid exposure><opioid induced overdose><opioid intake><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><opioid use><opioid use disorder><opioid withdrawal><opioid-receptor-like 1 protein><optogenetics><orphanin FQ receptor><overdose death><overdose fatalities><pain killer><pain medication><pain reliever><painkiller><pandemic><pandemic disease><peer><post-doc><post-doctoral><post-doctoral trainee><postsynaptic><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><presynaptic><receptor><research associates><response><side effect><skills><social role><standard care><standard treatment><summit><symposia><symposium><synapse><technical skills><thalamic><therapeutic opioid><tool><two-photon><under served community><underserved community><v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog><voltage clamp><μ opioid receptors><μ-OR><μOR>

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Brent Bever

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Exploratory lead · 30/100

Very recent

Active award

$53,433

FY 2026

Project Title

Identification of opioid-induced innate immune dysregulation among people living with HIV

Grant Number:

5R36DA061652-02

Activity Code:

R36

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Highly active antiretroviral therapy (ART) has dramatically improved survival and reduced progression to AIDS for people-living-with-HIV (PWH). However, PWH remain at significantly increased risk for diseases associated with chronic systemic inflammation, such as coronary artery dise...

Research Terms

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Kelly Anne Burke

UNIVERSITY OF CONNECTICUT STORRS, STORRS-MANSFIELD, CT

Exploratory lead · 30/100

Very recent

Active award

$39,349

FY 2026

Project Title

Implantable, Degradable Drug Delivery Devices for Non-Opioid Post-Surgical Pain Management

Grant Number:

3R18EB037603-01S1

Activity Code:

R18

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/17/2026

End Date:

8/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

One out of every nine Americans has surgery each year and 30-80% experience uncontrolled postoperative pain. There is a clear need to 1) localize treatment to simplify delivery and avoid systemic toxicity, 2) achieve long duration release to span the duration of postoperative pain without the need f...

Research Terms

<0-11 years old><21+ years old><Abdomen><Action Potentials><Address><Adult><Adult Human><American><Analgesia Tests><Anesthestic Drugs><Anesthetic Agents><Anesthetic Drugs><Anesthetics><Animal Model><Animal Models and Related Studies><Autonomic pain><Binding><Biocompatible Materials><Biomaterials><Blood Plasma><Body Tissues><Bupivacaine><Catheterization><Cell Survival><Cell Viability><Child><Child Youth><Children (0-21)><Clinical><Clinical Trials><Common Rat Strains><Conduction-Blocking Anesthetics><Device Designs><Devices><Diffusion><Dorsal Root Ganglia><Dose><Drug Controls><Drug Delivery><Drug Delivery Systems><Drug Kinetics><Drug usage><Drugs><Effectiveness><Environment><Evaluation><Fibroblasts><Film><Formulation><Foundations><Histologic><Histologically><Human><Human Figure><Human body><Hydrolysis><Hydrophobicity><Immune response><Implant><In Vitro><Infant><Inflammation><Legal patent><Link><Local Anesthetics><Location><Market Research><Measurement><Measures><Medication><Methods><Mice><Mice Mammals><Modeling><Modern Man><Molecular Interaction><Murine><Mus><Nature><Nerve><Nerve Block><Neural Block><Neural Blockade><Nociception Tests><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Otomy><Outcome><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Therapy><Pain management><Pain measure><Painful><Patents><Patients><Peritoneum><Pharmaceutical Agent><Pharmaceutical Preparations><Pharmaceuticals><Pharmacokinetics><Pharmacologic Substance><Pharmacological Substance><Plasma><Plasma Serum><Polymers><Post-operative Pain><Postoperative Pain><Predisposition><Procedures><Protein Biosynthesis><Proteins><Public Health><Rat><Rats Mammals><Rattus><Research><Reticuloendothelial System, Serum, Plasma><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Risk><Safety><Scientist><Silk><Site><Specific qualifier value><Specified><Spinal Ganglia><Surface><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Surgical incisions><Surgical sutures><Susceptibility><Sutures><Techniques><Technology><Therapeutic><Time><Tissues><Transmission><Variant><Variation><Visceral pain><Visual><Work><abdominal wall><adulthood><animal efficacy><biocompatibility><biological material><biomaterial compatibility><chronic pain><clinical significance><clinically significant><controlled release><design><designing><diffused><diffuses><diffusing><diffusions><dorsal root ganglion><drug use><drug/agent><efficacy testing><experience><first in man><first-in-human><flexibility><flexible><healing><host response><hydrophilicity><immune system response><immunoresponse><implantation><improved><in vivo><incision><innovate><innovation><innovative><kids><liquid formulation><local drug delivery><manufacture><meeting><meetings><model of animal><multidisciplinary><new approaches><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><novel><novel approaches><novel strategies><novel strategy><opiate abuse><opiate drug abuse><opioid abuse><opioid drug abuse><pain after surgery><pain assay><pain intervention><pain reduction><pain scale><pain score><pain treatment><pharmaceutical><pharmacokinetic model><polymer><polymeric><post-surgical pain><postsurgical pain><protein synthesis><reduce pain><response><ropivacaine><safety assessment><success><surgery><systemic toxicity><transmission process><youngster>

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Emilia M Lefevre

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 22/100

Recent

Active award

$249,000

FY 2026

Project Title

Nucleus accumbens fast-spiking interneurons regulate opioid reward and addiction

Grant Number:

5R00DA052624-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Project Abstract

Project Abstract Opioid addiction is a public health crisis, characterized by compulsive drug seeking and a pervasive vulnerability to relapse, with few therapeutic options available. The nucleus accumbens (NAc) is a central hub within reward circuitry and plays a critical role in the motivational ...

Research Terms

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Yanaira Alonso Caraballo

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 22/100

Recent

Active award

$249,000

FY 2026

Project Title

Mapping the Functional and Anatomical Pathways from the Anterior and Posterior Paraventricular Nucleus of the Thalamus to the Nucleus Accumbens: Implications for Opioid Use

Grant Number:

4R00DA060895-02

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

11/30/2028

Project Abstract

PROJECT ABSTRACT Opioid Use Disorder (OUD) is a complex medical condition characterized by compulsive and maladaptive use of opioid substances, including prescribed pharmaceuticals (such as oxycodone) and illegal agents (such as heroin). It causes physiological, psychological, and sociological effec...

Research Terms

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Kevin R. Coffey

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 22/100

Recent

Active award

$248,908

FY 2026

Project Title

Determining if Activity in Specific Lateral Habenula Output Pathways Motivates Avoidance of Synthetic Opioid Withdrawal or Cue Induced Reinstatement

Grant Number:

5R00DA052571-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2021

End Date:

2/28/2027

Project Abstract

Project Summary Opioid abuse has reached epidemic proportions in the United States and is responsible for more than 40,000 overdose deaths each year 1. In particular, synthetic opioid addiction has proven to be extremely difficult to combat, in part because it generates powerful opponent processes i...

Research Terms

<20-kD Gene Caveolae Protein><Abstinence><Actiq><Acute><Animals><Award><Behavior><Behavioral><Behavioral Model><Brain region><CAV2><CAV2 gene><Calcium><Caveolin-2 Gene><Cell Nucleus><Common Rat Strains><Complex><Coupled><Cues><DNA Therapy><Disease><Disorder><Distress><Dose><Drug Delivery><Drug Delivery Systems><Drug Therapy><Drugs><Duragesic><Emotional><Emotions><Environment><Epidemic><Euphoria><Exposure to><Extinction><Fentanest><Fentanyl><Fentyl><Fiber><Future><Gene Transfer Clinical><Genetic Intervention><Grant><Habenula><Head><Image><In vivo two-photon calcium imaging><Individual><Injections><Jaw><Lateral><Learning><Light><Malaise><Medication><Mentors><Mentorship><Mesencephalon><Mid-brain><Midbrain><Midbrain structure><Modeling><Motivation><Naloxone><Narcan><Narcanti><Negative Reinforcer><Nerve Cells><Nerve Unit><Neural Cell><Neural Pathways><Neurobiology><Neurocyte><Neurons><Nucleus><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Opsin><Oral><Oral Administration><Oral Drug Administration><Output><Pain><Painful><Pathway interactions><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phase><Phentanyl><Photoradiation><Positive Reinforcer><Process><Production><Public Health><Rat><Rats Mammals><Rattus><Relapse><Research><Rewards><Rod-Opsin><Role><Scientist><Self Administered><Self Administration><Stress><Substance abuse problem><Tegmentum Mesencephali><Testing><Time><Training><Ultrasonic><Ultrasonics><United States><Ventral Tegmental Area><Withdrawal><Writing><abuse of substances><addiction><addictive disorder><behavior response><behavior test><behavioral response><behavioral test><career><combat><design><designing><dorsal raphe nucleus><drug intervention><drug treatment><drug/agent><dysphoria><experience><experiment><experimental group><experimental research><experimental study><experiments><fentanyl seeking><fentanyl self-administration><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><imaging><improved><in vivo calcium imaging><intraoral drug delivery><long-term abstinence><model development><model developments><negative affect><negative affectivity><neurobiological><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><opiate abuse><opiate deaths><opiate drug abuse><opiate mortality><opiate withdrawal><opioid abuse><opioid addiction><opioid deaths><opioid dependence><opioid dependent><opioid detox><opioid detoxification><opioid drug abuse><opioid mortality><opioid overdose death><opioid related death><opioid withdrawal><optogenetics><overdose death><overdose fatalities><pathway><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><programs><redshift><response><reward processing><skills><social role><substance abuse><synthetic opiate><synthetic opioid><tegmentum><tool><ventral tegmentum><vocalization>

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Karli Rae Hochstatter

FRIENDS RESEARCH INSTITUTE, INC., BALTIMORE, MD

Exploratory lead · 22/100

Recent

Active award

$236,700

FY 2026

Project Title

Leveraging a time-limited opportunity to study the impact of an intervention for individuals bereaved by drug overdose

Grant Number:

5R21DA062508-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Project Abstract

The ongoing opioid epidemic has created a large number of people who have lost family, friends, or other close peers to drug overdose. People bereaved by overdose often experience psychological stressors and disruptions to life, and are at greater risk of experiencing more severe grief symptoms, sub...

Research Terms

<21+ years old><Address><Adult><Adult Human><American><Anxiety><Awareness><Bereavement><Cessation of life><Control Groups><Country><Data><Death><Development><Disease><Disorder><Drug usage><Drugs><Effectiveness of Interventions><Emotional><Ensure><Family><Frequencies><Friends><Funding><Future><Grief><Grief reaction><HEAL Initiative><Health><Health Promotion><Helping End Addiction Long-term><Helping to End Addiction Long-term><Hospital Admission><Hospitalization><Individual><Intervention><Interview><Investigation><Life><Literature><Logistics><Major Depressive Disorder><Measures><Medical Examiners><Medication><Mental Depression><Mental Health><Mental Hygiene><Methods><NIH><National Institutes of Health><New York City><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Outcome><Overdose><PTSD><Persons><Pharmaceutical Preparations><Population><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Preventative intervention><Prevention program><Process><Psychological Health><Public Health><Random Allocation><Random Selection><Randomized><Reporting><Research><Research Design><Research Resources><Resources><Risk><Risk Behaviors><Risk Reduction><Risky Behavior><Salutogenesis><Service delivery model><Service model><Services><Severities><Social Network><Social Service><Social Work><Social Workers><Social outcome><Social support><Speed><Structure><Study Type><Subgroup><Substance Use Disorder><Survey Instrument><Surveys><Symptoms><Time><Training><United States National Institutes of Health><Vulnerable Populations><Work><acceptability and feasibility><adulthood><at risk behavior><behavior change><care delivery model><clinical depression><coping><depression><design><designing><developmental><drug use><drug/agent><evidence base><experience><health care delivery model><high risk><improved><injury-related death><innovate><innovation><innovative><interest><intervention delivery><intervention design><intervention for prevention><loved ones><major depression><major depression disorder><member><mortality><motivational enhancement therapy><motivational interview><non-medical opioid use><nonmedical opioid use><opiate crisis><opiate misuse><opioid addiction><opioid crisis><opioid dependence><opioid dependent><opioid epidemic><opioid misuse><outreach><overdose death><overdose fatalities><overdose risk><peer><physical conditioning><physical health><poor health outcome><post-trauma stress disorder><posttrauma stress disorder><prevent substance misuse><prevention intervention><preventional intervention strategy><preventive intervention><promoting health><psychological distress><psychological stresses><psychological stressor><randomisation><randomization><randomly assigned><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduced health outcome><reduces risk><reduces the risk><reducing risk><reducing the risk><response><risk-reducing><service delivery><social integration><social support network><study design><substance misuse><substance misuse prevention><substance use><substance use and disorder><substance using><success><therapy design><traumatic neurosis><treatment design><universal interventions><universal prevention><universal preventive interventions><universal preventive measure><vulnerable group><vulnerable individual><vulnerable people><worse health outcome>

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Ashok Kumar

WAYNE STATE UNIVERSITY, DETROIT, MI

Exploratory lead · 22/100

Recent

Active award

$231,000

FY 2026

Project Title

Differential impact of acute and chronic opioids on ocular innate immunity and infections

Grant Number:

5R21EY037082-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Project Abstract

Project Summary Opioid Use Disorder (OUD) poses serious consequences including overdose or death from excessive and prolonged use of prescribed or illicit opioids. The opioid epidemic has also resulted in a striking, nationwide increase in infectious diseases including HIV, hepatitis, and invasive b...

Research Terms

<(TNF)-α><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Actiq><Acute><Affect><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Bacterial Infections><Beta Proprotein Interleukin 1><Blood Plasma><Blood monocyte><Blood-Retinal Barrier><Body Tissues><Brain><Brain Nervous System><C auris><C. auris><Cachectin><Candida><Candida auris><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cessation of life><Chemotactic Cytokines><Chronic><Clinical Research><Clinical Study><Communicable Diseases><Consensus><Cultured Cells><Data><Death><Defense Mechanisms><Disease Outbreaks><Disseminated candidiasis><Disseminated candidosis><Drugs><Duragesic><Encephalon><Endophthalmitis><Exhibits><Exposure to><Eye><Eye Infections><Eyeball><Fentanest><Fentanyl><Fentyl><Frequencies><Fungus Diseases><Goals><HCV><HCV/HIV><HIV><HIV and HCV><HIV and hepatitis C><HIV-HCV><HIV/HCV><HIV/Hepatitis C><HPGF><Health><Hepatitis><Hepatitis C virus><Hepatocyte-Stimulating Factor><Homologous Chemotactic Cytokines><Human><Human Immunodeficiency Viruses><Hybridoma Growth Factor><Hyperalgesia><Hyperalgesic Sensations><IFN-beta 2><IFNB2><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL-6><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><IL6 Protein><Immune signaling><Immunity><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Impairment><In Vitro><Incidence><Individual><Infection><Infectious Diseases><Infectious Disorder><Inflammasome><Inflammatory Response><Infumorph><Innate Immune Response><Innate Immunity><Intercrines><Interleukin 1beta><Interleukin-1 beta><Interleukin-1β><Interleukin-6><Intracellular Communication and Signaling><Kadian><Kidney><Kidney Urinary System><Knowledge><LAV-HTLV-III><Lymphadenopathy-Associated Virus><MGI-2><MS Contin><MSir><Macrophage><Macrophage-Derived TNF><Marrow monocyte><Mediator><Medication><Mice><Mice Mammals><Modeling><Modern Man><Monilia><Monocyte-Derived TNF><Morphia><Morphine><Murine><Mus><Mycoses><Myeloid Cells><Myeloid Differentiation-Inducing Protein><Mφ><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Ocular Infections><Ophthalmia><Opiates><Opioid><Oramorph><Oramorph SR><Organ><Outbreaks><Outcome><Outer pigmented layer of retina><Overdose><Pain Control><Pain Therapy><Pain management><Pathogenesis><Patients><Peripheral><Phagocytes><Phagocytic Cell><Pharmaceutical Preparations><Phentanyl><Physical Dependence><Pigment cell layer of retina><Pigmented layer of retina><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Predisposition><Preinterleukin 1 Beta><Property><Publishing><Reporting><Research><Reticuloendothelial System, Serum, Plasma><Retina><Retinal Pigment Epithelium><Retinal pigment epithelial cells><Risk Factors><Roxanol><S aureus><S. aureus><SIS cytokines><Sampling><Severities><Sight><Signal Transduction><Signal Transduction Systems><Signaling><Staph aureus><Staphylococcus aureus><Statex SR><Structure of retinal pigment epithelium><Susceptibility><Systemic candida><Systemic candida infections><Systemic candidiasis><Systemic infection><TLR protein><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Therapeutic Intervention><Tissues><Toll-Like Receptor Family Gene><Toll-like receptors><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><United States><Virus-HIV><Vision><amebocyte><bacteria infection><bacterial disease><biological signal transduction><chemoattractant cytokine><chemokine><cytokine><drug/agent><epidemiology research study><epidemiology study><epidemiology survey><experiment><experimental research><experimental study><experiments><fentanyl exposure><fungal infection><fungus infection><hyperalgia><illicit opiate><illicit opioid><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressive activity><immunosuppressive function><immunosuppressive response><improved><improved outcome><in vivo><in vivo Model><interferon beta 2><intervention therapy><intravenous drug use><licit opioid><monocyte><morphine administration><mouse model><mu opioid receptors><murine model><opiate consumption><opiate crisis><opiate drug use><opiate exposure><opiate intake><opiate medication><opiate use><opiate use disorder><opioid consumption><opioid crisis><opioid drug use><opioid epidemic><opioid exposure><opioid intake><opioid medication><opioid use><opioid use disorder><pain intervention><pain killer><pain medication><pain reliever><pain treatment><painkiller><pathogen><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><preservation><psychological defense mechanism><renal><response><substance abuser><substance use><substance using><visual function><μ opioid receptors><μ-OR><μOR>

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Max E Joffe

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 22/100

Recent

Active award

$198,750

FY 2026

Project Title

Effects of xylazine and opioids on prefrontal cortex inhibitory transmission

Grant Number:

5R21DA062048-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

Xylazine is now highly prevalent in illicit supplies of opioids and poses an emerging threat to public health. While the compound is used in veterinary medicine for its sedative effects mediated by α2 adrenergic receptors, little is known about its acute or persistent effects on brain circuits invol...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><Acute><Address><Adrenergic Receptor><Adrenoceptors><Affect><Affective><Agonist><Aminalon><Aminalone><Anterior><Area><Attenuated><Bathing><Baths><Behavior><Brain><Brain Nervous System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cognition><Connector Neuron><Data><Data Systems><Dependence><Development><Dihydrohydroxycodeinone><Drugs><Electrophysiology><Electrophysiology (science)><Encephalon><Epinephrine Receptors><Forensic Medicine><Forensics><GABA><History><Human><Hyperalgesia><Hyperalgesic Sensations><IT Systems><Individual><Influentials><Information Systems><Information Technology Systems><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><Ligands><Mediating><Medication><Mice><Mice Mammals><Modern Man><Molecular><Motivation><Murine><Mus><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Neurophysiology - biologic function><Neurophysiology / Electrophysiology><Opiate Addiction><Opiate Dependence><Opiate Receptors><Opiates><Opioid><Opioid Receptor><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Pain><Painful><Pharmaceutical Preparations><Pharmacology><Pre-Clinical Model><Preclinical Models><Prefrontal Cortex><Property><Public Health><Pyramidal Cells><Receptor Protein><Receptor Signaling><Recording of previous events><Research><Rewards><Risk><Rodent><Rodentia><Rodents Mammals><Roxicodone><Series><Signal Transduction><Signal Transduction Systems><Signaling><Site><Slice><Study models><Substance Use Disorder><Synaptic plasticity><Testing><Transmission><Veterinary Medicine><Viral><Withdrawal><Xylaxine><Xylazine><adenoreceptor><affective disturbance><antagonism><antagonist><attenuate><attenuates><biological signal transduction><cell type><cingulate cortex><craving><design><designing><developmental><disturbance in affect><drug/agent><dysphoria><electrophysiological><experiment><experimental research><experimental study><experiments><gamma-Aminobutyric Acid><histories><hyperalgia><innovate><innovation><innovative><interest><mood alteration><mood and affect disturbance><mood disturbance><mood dysfunction><neocortical><neural circuit><neural circuitry><neural function><neurocircuitry><novel><opiate consumption><opiate deaths><opiate drug use><opiate intake><opiate mortality><opiate use><opiate use disorder><opioid addiction><opioid consumption><opioid deaths><opioid dependence><opioid dependent><opioid drug use><opioid intake><opioid mortality><opioid overdose death><opioid related death><opioid use><opioid use disorder><postsynaptic><presynaptic><receptor><sedative><substance use and disorder><synaptic circuit><synaptic circuitry><tool><transmission process><γ-Aminobutyric Acid>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

SANDRA D. COMER

NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NEW YORK, NY

Exploratory lead · 22/100

Recent

Active award

$190,220

FY 2026

Project Title

Church-Tailored Opioid Overdose Education and Naloxone Distribution to Target Overdose and Stigma Among African-American Communities

Grant Number:

5R34DA055151-03

Activity Code:

R34

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2022

End Date:

2/28/2027

Project Abstract

African Americans (AAs) are dying from opioid overdoses faster than any racial/ethnic group in the United States. Furthermore, the increased adulteration of cocaine with fentanyl may further exacerbate the risk of opioid overdose among AAs. Over the past 10 years, peer-based overdose education and n...

Research Terms

<21+ years old><911 call><Accounting><Actiq><Active Follow-up><Address><Adult><Adult Human><African American><African American church><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><Alcohol Drinking><Alcohol consumption><American><Attitude><Black><Black church><Black race><Breathing><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Church><Clergy><Clinical><Cocaine><Communities><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Curriculum><Data><Death Rate><Development><Dose><Drug Abuse Treatment Centers><Drug Adulterations><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Drug Rehabilitation Centers><Drug Therapy><Drug Treatment Centers><Drug Use Disorder><Drug usage><Drugs><Duragesic><Education and Training><Educational Curriculum><Effectiveness><EtOH drinking><EtOH use><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Event><Evidence based intervention><Exposure to><Faith><Family><Family member><Fentanest><Fentanyl><Fentyl><First Aid><Friends><Harm Minimization><Harm Reduction><Health><Health Inequity><Health Services><Heroin Users><Hybrids><Imprisonment><Individual><Inequalities in Health><Inequities in Health><Inpatients><Intervention><Interview><Investigators><Knowledge><Medication><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Methods><Modeling><Modification><NIDA><Naloxone><Narcan><Narcanti><National Institute of Drug Abuse><National Institute on Drug Abuse><Needle-Exchange Programs><Neighborhoods><New York><New York City><Opiate user><Opioid drug user><Overdose><Overdose reversal><PWUO><Participant><Perception><Persons><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phase><Phase I Study><Phentanyl><Pilot Projects><Police><Prison Inmates><Prisoner><Process><Psychological Health><Public Health><Race><Races><Racial Group><Randomized><Randomized, Controlled Trials><Research><Research Personnel><Research Resources><Researchers><Resources><Respiratory Aspiration><Respiratory Inspiration><Risk><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Site><Societies><Sodium Chloride><Stimulant><Study Subject><Substance Use Disorder><Symptoms><Syringe-Exchange Programs><Testing><Tobacco Use Disorder><Training><Training and Education><United States><Variant><Variation><active followup><adulthood><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><community advisory board><community advisory committee><community advisory panel><community setting><compare treatment><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><correctional institution resident><curriculum development><design><designing><detoxification><developmental><disparities in race><disparity due to race><distribute naloxone><drug intervention><drug treatment><drug use><drug/agent><effectiveness and implementation trial><effectiveness/implementation hybrid trial><effectiveness/implementation trial><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><ethnic subgroup><ethnicity group><experience><facilitators to implementation><follow up><follow-up><followed up><followup><health economics><health inequalities><health literacy><help seeking><help-seeking behavior><high risk><high risk group><high risk individual><high risk people><high risk population><implementation facilitators><implementation outcomes><implementation science><implementation strategy><implementation/effectiveness><improved><incarcerated><incarceration><ineffective therapies><ineffective treatment><inequality due to race><inequity due to race><inspiration><intervention mapping><jail inmate><lesson plans><medication for opioid use disorder><member><mental health care><mortality rate><naloxone availability><naloxone dispensary><naloxone dispensation><naloxone dispensing><naloxone distribution><naloxone provision><needle exchange><novel><opiate consumption><opiate deaths><opiate drug use><opiate intake><opiate mortality><opiate overdose><opiate related overdose><opiate use><opioid consumption><opioid deaths><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid toxicity><opioid use><opioid user><overdose education><overdose risk><peer><people who use opioids><persons who use opioids><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phase 1 study><pilot study><pilot test><pilot trial><primary outcome><process evaluation><programs><provide naloxone><psychostimulant use disorder><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial origin><racial population><racial subgroup><racially unequal><randomisation><randomization><randomized control trial><randomly assigned><reduced substance use><reduction in substance use><response><reverse overdose><salt><secondary outcome><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skills training><social cultural factor><social culture><social culture determinant><social stigma><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><stigma><stimulant use disorder><strategies for implementation><structural determinants><structural factors><substance use and disorder><substance use reduction><synthetic opiate><synthetic opioid><syringe exchange><syringe exchange services><syringe service programs><syringe services><tobacco disorder><treatment center><treatment comparison><uptake><urban environment><urban setting>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

SIDNEY H HANKERSON

NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NEW YORK, NY

Exploratory lead · 22/100

Recent

Active award

$190,220

FY 2026

Project Title

Church-Tailored Opioid Overdose Education and Naloxone Distribution to Target Overdose and Stigma Among African-American Communities

Grant Number:

5R34DA055151-03

Activity Code:

R34

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2022

End Date:

2/28/2027

Project Abstract

African Americans (AAs) are dying from opioid overdoses faster than any racial/ethnic group in the United States. Furthermore, the increased adulteration of cocaine with fentanyl may further exacerbate the risk of opioid overdose among AAs. Over the past 10 years, peer-based overdose education and n...

Research Terms

<21+ years old><911 call><Accounting><Actiq><Active Follow-up><Address><Adult><Adult Human><African American><African American church><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><Alcohol Drinking><Alcohol consumption><American><Attitude><Black><Black church><Black race><Breathing><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Church><Clergy><Clinical><Cocaine><Communities><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Curriculum><Data><Death Rate><Development><Dose><Drug Abuse Treatment Centers><Drug Adulterations><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Drug Rehabilitation Centers><Drug Therapy><Drug Treatment Centers><Drug Use Disorder><Drug usage><Drugs><Duragesic><Education and Training><Educational Curriculum><Effectiveness><EtOH drinking><EtOH use><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Event><Evidence based intervention><Exposure to><Faith><Family><Family member><Fentanest><Fentanyl><Fentyl><First Aid><Friends><Harm Minimization><Harm Reduction><Health><Health Inequity><Health Services><Heroin Users><Hybrids><Imprisonment><Individual><Inequalities in Health><Inequities in Health><Inpatients><Intervention><Interview><Investigators><Knowledge><Medication><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Methods><Modeling><Modification><NIDA><Naloxone><Narcan><Narcanti><National Institute of Drug Abuse><National Institute on Drug Abuse><Needle-Exchange Programs><Neighborhoods><New York><New York City><Opiate user><Opioid drug user><Overdose><Overdose reversal><PWUO><Participant><Perception><Persons><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phase><Phase I Study><Phentanyl><Pilot Projects><Police><Prison Inmates><Prisoner><Process><Psychological Health><Public Health><Race><Races><Racial Group><Randomized><Randomized, Controlled Trials><Research><Research Personnel><Research Resources><Researchers><Resources><Respiratory Aspiration><Respiratory Inspiration><Risk><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Site><Societies><Sodium Chloride><Stimulant><Study Subject><Substance Use Disorder><Symptoms><Syringe-Exchange Programs><Testing><Tobacco Use Disorder><Training><Training and Education><United States><Variant><Variation><active followup><adulthood><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><community advisory board><community advisory committee><community advisory panel><community setting><compare treatment><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><correctional institution resident><curriculum development><design><designing><detoxification><developmental><disparities in race><disparity due to race><distribute naloxone><drug intervention><drug treatment><drug use><drug/agent><effectiveness and implementation trial><effectiveness/implementation hybrid trial><effectiveness/implementation trial><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><ethnic subgroup><ethnicity group><experience><facilitators to implementation><follow up><follow-up><followed up><followup><health economics><health inequalities><health literacy><help seeking><help-seeking behavior><high risk><high risk group><high risk individual><high risk people><high risk population><implementation facilitators><implementation outcomes><implementation science><implementation strategy><implementation/effectiveness><improved><incarcerated><incarceration><ineffective therapies><ineffective treatment><inequality due to race><inequity due to race><inspiration><intervention mapping><jail inmate><lesson plans><medication for opioid use disorder><member><mental health care><mortality rate><naloxone availability><naloxone dispensary><naloxone dispensation><naloxone dispensing><naloxone distribution><naloxone provision><needle exchange><novel><opiate consumption><opiate deaths><opiate drug use><opiate intake><opiate mortality><opiate overdose><opiate related overdose><opiate use><opioid consumption><opioid deaths><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid toxicity><opioid use><opioid user><overdose education><overdose risk><peer><people who use opioids><persons who use opioids><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phase 1 study><pilot study><pilot test><pilot trial><primary outcome><process evaluation><programs><provide naloxone><psychostimulant use disorder><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial origin><racial population><racial subgroup><racially unequal><randomisation><randomization><randomized control trial><randomly assigned><reduced substance use><reduction in substance use><response><reverse overdose><salt><secondary outcome><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skills training><social cultural factor><social culture><social culture determinant><social stigma><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><stigma><stimulant use disorder><strategies for implementation><structural determinants><structural factors><substance use and disorder><substance use reduction><synthetic opiate><synthetic opioid><syringe exchange><syringe exchange services><syringe service programs><syringe services><tobacco disorder><treatment center><treatment comparison><uptake><urban environment><urban setting>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JERMAINE D JONES

NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NEW YORK, NY

Exploratory lead · 22/100

Recent

Active award

$190,220

FY 2026

Project Title

Church-Tailored Opioid Overdose Education and Naloxone Distribution to Target Overdose and Stigma Among African-American Communities

Grant Number:

5R34DA055151-03

Activity Code:

R34

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2022

End Date:

2/28/2027

Project Abstract

African Americans (AAs) are dying from opioid overdoses faster than any racial/ethnic group in the United States. Furthermore, the increased adulteration of cocaine with fentanyl may further exacerbate the risk of opioid overdose among AAs. Over the past 10 years, peer-based overdose education and n...

Research Terms

<21+ years old><911 call><Accounting><Actiq><Active Follow-up><Address><Adult><Adult Human><African American><African American church><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><Alcohol Drinking><Alcohol consumption><American><Attitude><Black><Black church><Black race><Breathing><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Church><Clergy><Clinical><Cocaine><Communities><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Curriculum><Data><Death Rate><Development><Dose><Drug Abuse Treatment Centers><Drug Adulterations><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Drug Rehabilitation Centers><Drug Therapy><Drug Treatment Centers><Drug Use Disorder><Drug usage><Drugs><Duragesic><Education and Training><Educational Curriculum><Effectiveness><EtOH drinking><EtOH use><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Event><Evidence based intervention><Exposure to><Faith><Family><Family member><Fentanest><Fentanyl><Fentyl><First Aid><Friends><Harm Minimization><Harm Reduction><Health><Health Inequity><Health Services><Heroin Users><Hybrids><Imprisonment><Individual><Inequalities in Health><Inequities in Health><Inpatients><Intervention><Interview><Investigators><Knowledge><Medication><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Metabolic Drug Detoxications><Metabolism of Toxic Agents><Methods><Modeling><Modification><NIDA><Naloxone><Narcan><Narcanti><National Institute of Drug Abuse><National Institute on Drug Abuse><Needle-Exchange Programs><Neighborhoods><New York><New York City><Opiate user><Opioid drug user><Overdose><Overdose reversal><PWUO><Participant><Perception><Persons><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phase><Phase I Study><Phentanyl><Pilot Projects><Police><Prison Inmates><Prisoner><Process><Psychological Health><Public Health><Race><Races><Racial Group><Randomized><Randomized, Controlled Trials><Research><Research Personnel><Research Resources><Researchers><Resources><Respiratory Aspiration><Respiratory Inspiration><Risk><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Site><Societies><Sodium Chloride><Stimulant><Study Subject><Substance Use Disorder><Symptoms><Syringe-Exchange Programs><Testing><Tobacco Use Disorder><Training><Training and Education><United States><Variant><Variation><active followup><adulthood><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><community advisory board><community advisory committee><community advisory panel><community setting><compare treatment><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><correctional institution resident><curriculum development><design><designing><detoxification><developmental><disparities in race><disparity due to race><distribute naloxone><drug intervention><drug treatment><drug use><drug/agent><effectiveness and implementation trial><effectiveness/implementation hybrid trial><effectiveness/implementation trial><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><ethnic subgroup><ethnicity group><experience><facilitators to implementation><follow up><follow-up><followed up><followup><health economics><health inequalities><health literacy><help seeking><help-seeking behavior><high risk><high risk group><high risk individual><high risk people><high risk population><implementation facilitators><implementation outcomes><implementation science><implementation strategy><implementation/effectiveness><improved><incarcerated><incarceration><ineffective therapies><ineffective treatment><inequality due to race><inequity due to race><inspiration><intervention mapping><jail inmate><lesson plans><medication for opioid use disorder><member><mental health care><mortality rate><naloxone availability><naloxone dispensary><naloxone dispensation><naloxone dispensing><naloxone distribution><naloxone provision><needle exchange><novel><opiate consumption><opiate deaths><opiate drug use><opiate intake><opiate mortality><opiate overdose><opiate related overdose><opiate use><opioid consumption><opioid deaths><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication overdose><opioid mortality><opioid overdose><opioid overdose death><opioid poisoning><opioid related death><opioid related overdose><opioid toxicity><opioid use><opioid user><overdose education><overdose risk><peer><people who use opioids><persons who use opioids><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phase 1 study><pilot study><pilot test><pilot trial><primary outcome><process evaluation><programs><provide naloxone><psychostimulant use disorder><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial origin><racial population><racial subgroup><racially unequal><randomisation><randomization><randomized control trial><randomly assigned><reduced substance use><reduction in substance use><response><reverse overdose><salt><secondary outcome><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skills training><social cultural factor><social culture><social culture determinant><social stigma><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><stigma><stimulant use disorder><strategies for implementation><structural determinants><structural factors><substance use and disorder><substance use reduction><synthetic opiate><synthetic opioid><syringe exchange><syringe exchange services><syringe service programs><syringe services><tobacco disorder><treatment center><treatment comparison><uptake><urban environment><urban setting>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Aaliyah Tyson

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Exploratory lead · 22/100

Recent

Active award

$108,000

FY 2026

Project Title

Decoding the Molecular Mechanisms of a Kappa Opioid Receptor Selective Negative Allosteric Modulator

Grant Number:

1R36DA064987-01

Activity Code:

R36

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2028

Project Abstract

Project Summary The widespread prescription and illicit use of opioids over the past several decades has created a public health epidemic known as the "opioid crisis." Synthetic opioids acting as Mu Opioid receptor (µOR) agonists have demonstrated effectiveness as pain management therapeutics yet ha...

Research Terms

<3'5'-cyclic ester of AMP><Actiq><Address><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Affective Disorders><Affinity><Agonist><Allosteric Regulation><Assay><Attention><Automobile Driving><Behavior><Binding><Bioassay><Biochemical><Biological Assay><Biology><Cell Communication and Signaling><Cell Signaling><Chemicals><Clinical><Clinical Trials><Complex><Coupled><Coupling><Cryo-electron Microscopy><Cryoelectron Microscopy><Cyclic AMP><DNA mutation><Development><Disease><Disorder><Duragesic><Effectiveness><Electron Cryomicroscopy><Emotional><Epidemic><Exhibits><Family><Fentanest><Fentanyl><Fentyl><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G Protein-Coupled Receptor Signaling><G-Protein-Coupled Receptors><G-Proteins><GPCR><GPCR Signaling><GTP><GTP-Binding Proteins><GTP-Regulatory Proteins><Genetic Change><Genetic defect><Genetic mutation><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><Guanosine Triphosphate><Heterotrimeric G-Proteins><Heterotrimeric GTP-Binding Proteins><In Vitro><Infumorph><Intracellular Communication and Signaling><Kadian><L-Tryptophan><Levotryptophan><Ligands><Link><MS Contin><MSir><Measures><Mediating><Modeling><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Monitor><Mood Disorders><Morphia><Morphine><Mutation><Naloxone><Narcan><Narcanti><Nature><Nucleotides><Opiate Peptides><Opiate Receptors><Opiates><Opioid><Opioid Peptide><Opioid Receptor><Oramorph><Oramorph SR><Outcome><Overdose><Pain Control><Pain Therapy><Pain management><Pathway interactions><Pharmacology><Phentanyl><Protein Dynamics><Public Health><Publishing><Receptor Activation><Receptor Inhibition><Receptor Protein><Receptor Signaling><Relapse><Research><Residual><Residual state><Resolution><Risk><Role><Roxanol><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Site><Statex SR><Stress><Structure><Substance Use Disorder><Techniques><Testing><Therapeutic><Therapeutic Uses><Tryptophan><Withdrawal><Withdrawal Symptom><Work><addiction><addictive disorder><adenosine 3'5' monophosphate><antagonism><antagonist><biological signal transduction><biophysical approaches><biophysical methodology><biophysical methods><biophysical techniques><cAMP><conformation><conformational><conformational state><conformationally><conformations><cryo-EM><cryoEM><cryogenic electron microscopy><design><designing><developmental><driving><genome mutation><improved><in vivo><inhibitor><insight><kappa opiate><kappa opioid><kappa opioid receptors><molecular recognition><mood regulation><mu opioid receptors><negative emotional state><nor-BNI><nor-binaltorphimine><norbinaltorphimine><novel><opiate crisis><opiate overdose><opiate related overdose><opioid crisis><opioid drug overdose><opioid epidemic><opioid induced overdose><opioid intoxication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid toxicity><pain intervention><pain relief><pain treatment><pathway><pharmacologic><pre-clinical study><preclinical study><preference><protein activation><protein complex><receptor><receptor binding><receptor bound><receptor function><relieve pain><resolutions><side effect><social role><structural biology><substance use and disorder><substance use treatment><synthetic opiate><synthetic opioid><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic outcome><therapeutic target><therapeutically effective><therapy outcome><treatment-refractory depression><treatment-resistant depression><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR><μ opioid receptors><μ-OR><μOR>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Marek Schwendt

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 22/100

Recent

Active award

$76,250

FY 2026

Project Title

Assessing the dose- and sex-dependent effects of oxytocin on opioid demand and reinstatement

Grant Number:

5R03DA059681-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2026

Project Abstract

ABSTRACT While there are several FDA-approved medications for opioid use disorder, they are not effective at reducing opioid intake and preventing relapse in all individuals. Additional treatment options are needed. One compound that has been shown to reduce intake of multiple classes of drugs is th...

Research Terms

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MICHAEL BUYS

VA SALT LAKE CITY HEALTHCARE SYSTEM, SALT LAKE CITY, UT

Exploratory lead · 22/100

Recent

Active award

$0

FY 2026

Project Title

Reducing Chronic Opioid Use Among Veterans Undergoing Community Care Surgery Using a Transitional Pain Service

Grant Number:

5I01HX003599-03

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

2/1/2024

End Date:

1/31/2028

Project Abstract

Background: The VA Community Care program has improved access to surgical care for Veterans unable to have treatment at VA Medical Centers in a timely fashion. However, the delivery of surgical care outside the VA poses barriers to care coordination for pain management during the transitions before ...

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Benjamin S. Brooke

VA SALT LAKE CITY HEALTHCARE SYSTEM, SALT LAKE CITY, UT

Exploratory lead · 22/100

Recent

Active award

$0

FY 2026

Project Title

Reducing Chronic Opioid Use Among Veterans Undergoing Community Care Surgery Using a Transitional Pain Service

Grant Number:

5I01HX003599-03

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

2/1/2024

End Date:

1/31/2028

Project Abstract

Background: The VA Community Care program has improved access to surgical care for Veterans unable to have treatment at VA Medical Centers in a timely fashion. However, the delivery of surgical care outside the VA poses barriers to care coordination for pain management during the transitions before ...

Research Terms

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Elizabeth M. Oliva

VETERANS ADMIN PALO ALTO HEALTH CARE SYS, PALO ALTO, CA

Exploratory lead · 22/100

Recent

Active award

$0

FY 2026

Project Title

Strategies to improve Utilization of Post-overdose Evidence-based Risk mitigation among Non-fatal Overdoses in VA (SUPER NOVA)

Grant Number:

5I01HX003403-04

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

2/1/2023

End Date:

1/31/2027

Project Abstract

Background: Drug overdose is a leading cause of death, accounting for 70,630 deaths in the United States (US) in 20193. The majority of drug overdoses involve opioids, and opioid-involved stimulant deaths are rising with 3 out of every 4 cocaine-related deaths involving opioids and 53% of psychostim...

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WILLIAM C BECKER

VA CONNECTICUT HEALTHCARE SYSTEM, WEST HAVEN, CT

Exploratory lead · 18/100

Active award

Team-scale grant

$0

FY 2026

Project Title

Pain management teams using Whole Health to optimize function and safety in veterans: The TEAMWORK trial

Grant Number:

5UG3HX003997-02

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2024

End Date:

9/30/2029

Project Abstract

The intersecting problems of high-impact chronic pain and the opioid overdose crisis continue to be major public health concerns because of prevalence, costs, disparities, and societal burden, yet very few solutions to support comorbid chronic pain, opioid dependence, and opioid-related harms are av...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><American><Analgesia Tests><Assess implementation><Behavioral><Behavioral Medicine><Buprenorphine><Caring><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Clinic><Combined Modality Therapy><Connecticut><Data><Development><Disparities><Disparity><Drugs><Effectiveness><Electronic Health Record><Emotional><Environment><Evaluation><Exhibits><Goals><Guidelines><Health><Health Care Systems><Hybrids><Implementation assessment><Individual><Intervention><Interview><Maintenance><Medication><Medicine><Methods><Modeling><Multimodal Therapy><Multimodal Treatment><Narcotic Rotation><Narcotic Substitution><Narcotic Switching><Nociception Tests><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Opioid Rotation><Opioid Substitution><Opioid Switching><Outcome><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Therapy><Pain management><Pain measure><Painful><Patient Self-Report><Patients><Personal Satisfaction><Persons><Pharmaceutical Preparations><Phase><Physiatrics><Physiatry><Physical Function><Physical Medicine><Preparation><Prevalence><Provider><Public Health><RE-AIM><Randomized><Randomized, Controlled Trials><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Recommendation><Recovery><Rehabilitation Medicine><Research><Safety><Self-Report><Site><Testing><Training><Treatment Effectiveness><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Veterans><Veterans Health Administration><Veterans Health Affairs><Work><addiction><addictive disorder><adulthood><assess effectiveness><biopsychosocial><budget impact><care as usual><chronic pain><chronic pain patient><co-morbid><co-morbidity><combination therapy><combined modality treatment><combined treatment><comorbidity><compare cost><compare effectiveness><cost><cost comparison><determine effectiveness><developmental><drug/agent><effectiveness and implementation trial><effectiveness assessment><effectiveness evaluation><effectiveness/implementation hybrid><effectiveness/implementation hybrid trial><effectiveness/implementation trial><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><evaluate effectiveness><evaluate implementation><evaluation of implementation><examine effectiveness><experience><formative assessment><formative evaluation><functional improvement><health care model><health determinants><high risk><hybrid type 2 trial><hybrid type II trial><implementation cost><implementation evaluation><implementation facilitation><implementation investment><improve function><improved><improved functional outcomes><licit opioid><life span><lifespan><multi-modal therapy><multi-modal treatment><multi-modality><multidisciplinary><multimodality><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><opiate consumption><opiate drug use><opiate intake><opiate medication><opiate overdose><opiate related overdose><opiate therapy><opiate use><opioid addiction><opioid consumption><opioid dependence><opioid dependent><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid tapering><opioid therapy><opioid toxicity><opioid use><pain assay><pain intervention><pain outcome><pain treatment><pain-related outcome><participant engagement><participant enrollment><patient centered><patient engagement><patient enrollment><patient oriented><patient with chronic pain><pragmatic effectiveness trial><pragmatic randomized trial><pragmatic trial><preparations><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><randomisation><randomization><randomized control trial><randomly assigned><reach, efficacy, adoption, implementation, and maintenance><safety outcomes><secondary outcome><social><team-based care><treatment as usual><treatment planning><usual care><well-being><wellbeing><whole health><whole person health>

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Sara Edmond

VA CONNECTICUT HEALTHCARE SYSTEM, WEST HAVEN, CT

Exploratory lead · 18/100

Active award

Team-scale grant

$0

FY 2026

Project Title

Pain management teams using Whole Health to optimize function and safety in veterans: The TEAMWORK trial

Grant Number:

5UG3HX003997-02

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2024

End Date:

9/30/2029

Project Abstract

The intersecting problems of high-impact chronic pain and the opioid overdose crisis continue to be major public health concerns because of prevalence, costs, disparities, and societal burden, yet very few solutions to support comorbid chronic pain, opioid dependence, and opioid-related harms are av...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><American><Analgesia Tests><Assess implementation><Behavioral><Behavioral Medicine><Buprenorphine><Caring><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Clinic><Combined Modality Therapy><Connecticut><Data><Development><Disparities><Disparity><Drugs><Effectiveness><Electronic Health Record><Emotional><Environment><Evaluation><Exhibits><Goals><Guidelines><Health><Health Care Systems><Hybrids><Implementation assessment><Individual><Intervention><Interview><Maintenance><Medication><Medicine><Methods><Modeling><Multimodal Therapy><Multimodal Treatment><Narcotic Rotation><Narcotic Substitution><Narcotic Switching><Nociception Tests><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Opioid Rotation><Opioid Substitution><Opioid Switching><Outcome><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Therapy><Pain management><Pain measure><Painful><Patient Self-Report><Patients><Personal Satisfaction><Persons><Pharmaceutical Preparations><Phase><Physiatrics><Physiatry><Physical Function><Physical Medicine><Preparation><Prevalence><Provider><Public Health><RE-AIM><Randomized><Randomized, Controlled Trials><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Recommendation><Recovery><Rehabilitation Medicine><Research><Safety><Self-Report><Site><Testing><Training><Treatment Effectiveness><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Veterans><Veterans Health Administration><Veterans Health Affairs><Work><addiction><addictive disorder><adulthood><assess effectiveness><biopsychosocial><budget impact><care as usual><chronic pain><chronic pain patient><co-morbid><co-morbidity><combination therapy><combined modality treatment><combined treatment><comorbidity><compare cost><compare effectiveness><cost><cost comparison><determine effectiveness><developmental><drug/agent><effectiveness and implementation trial><effectiveness assessment><effectiveness evaluation><effectiveness/implementation hybrid><effectiveness/implementation hybrid trial><effectiveness/implementation trial><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><evaluate effectiveness><evaluate implementation><evaluation of implementation><examine effectiveness><experience><formative assessment><formative evaluation><functional improvement><health care model><health determinants><high risk><hybrid type 2 trial><hybrid type II trial><implementation cost><implementation evaluation><implementation facilitation><implementation investment><improve function><improved><improved functional outcomes><licit opioid><life span><lifespan><multi-modal therapy><multi-modal treatment><multi-modality><multidisciplinary><multimodality><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><opiate consumption><opiate drug use><opiate intake><opiate medication><opiate overdose><opiate related overdose><opiate therapy><opiate use><opioid addiction><opioid consumption><opioid dependence><opioid dependent><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid tapering><opioid therapy><opioid toxicity><opioid use><pain assay><pain intervention><pain outcome><pain treatment><pain-related outcome><participant engagement><participant enrollment><patient centered><patient engagement><patient enrollment><patient oriented><patient with chronic pain><pragmatic effectiveness trial><pragmatic randomized trial><pragmatic trial><preparations><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><randomisation><randomization><randomized control trial><randomly assigned><reach, efficacy, adoption, implementation, and maintenance><safety outcomes><secondary outcome><social><team-based care><treatment as usual><treatment planning><usual care><well-being><wellbeing><whole health><whole person health>

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Karen H Seal

VA CONNECTICUT HEALTHCARE SYSTEM, WEST HAVEN, CT

Exploratory lead · 18/100

Active award

Team-scale grant

$0

FY 2026

Project Title

Pain management teams using Whole Health to optimize function and safety in veterans: The TEAMWORK trial

Grant Number:

5UG3HX003997-02

Activity Code:

UG3

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2024

End Date:

9/30/2029

Project Abstract

The intersecting problems of high-impact chronic pain and the opioid overdose crisis continue to be major public health concerns because of prevalence, costs, disparities, and societal burden, yet very few solutions to support comorbid chronic pain, opioid dependence, and opioid-related harms are av...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><American><Analgesia Tests><Assess implementation><Behavioral><Behavioral Medicine><Buprenorphine><Caring><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Clinic><Combined Modality Therapy><Connecticut><Data><Development><Disparities><Disparity><Drugs><Effectiveness><Electronic Health Record><Emotional><Environment><Evaluation><Exhibits><Goals><Guidelines><Health><Health Care Systems><Hybrids><Implementation assessment><Individual><Intervention><Interview><Maintenance><Medication><Medicine><Methods><Modeling><Multimodal Therapy><Multimodal Treatment><Narcotic Rotation><Narcotic Substitution><Narcotic Switching><Nociception Tests><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Opioid Rotation><Opioid Substitution><Opioid Switching><Outcome><Pain><Pain Assessment><Pain Control><Pain Measurement><Pain Therapy><Pain management><Pain measure><Painful><Patient Self-Report><Patients><Personal Satisfaction><Persons><Pharmaceutical Preparations><Phase><Physiatrics><Physiatry><Physical Function><Physical Medicine><Preparation><Prevalence><Provider><Public Health><RE-AIM><Randomized><Randomized, Controlled Trials><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Recommendation><Recovery><Rehabilitation Medicine><Research><Safety><Self-Report><Site><Testing><Training><Treatment Effectiveness><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Veterans><Veterans Health Administration><Veterans Health Affairs><Work><addiction><addictive disorder><adulthood><assess effectiveness><biopsychosocial><budget impact><care as usual><chronic pain><chronic pain patient><co-morbid><co-morbidity><combination therapy><combined modality treatment><combined treatment><comorbidity><compare cost><compare effectiveness><cost><cost comparison><determine effectiveness><developmental><drug/agent><effectiveness and implementation trial><effectiveness assessment><effectiveness evaluation><effectiveness/implementation hybrid><effectiveness/implementation hybrid trial><effectiveness/implementation trial><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><evaluate effectiveness><evaluate implementation><evaluation of implementation><examine effectiveness><experience><formative assessment><formative evaluation><functional improvement><health care model><health determinants><high risk><hybrid type 2 trial><hybrid type II trial><implementation cost><implementation evaluation><implementation facilitation><implementation investment><improve function><improved><improved functional outcomes><licit opioid><life span><lifespan><multi-modal therapy><multi-modal treatment><multi-modality><multidisciplinary><multimodality><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><opiate consumption><opiate drug use><opiate intake><opiate medication><opiate overdose><opiate related overdose><opiate therapy><opiate use><opioid addiction><opioid consumption><opioid dependence><opioid dependent><opioid drug overdose><opioid drug use><opioid induced overdose><opioid intake><opioid intoxication><opioid medication><opioid medication overdose><opioid overdose><opioid poisoning><opioid related overdose><opioid tapering><opioid therapy><opioid toxicity><opioid use><pain assay><pain intervention><pain outcome><pain treatment><pain-related outcome><participant engagement><participant enrollment><patient centered><patient engagement><patient enrollment><patient oriented><patient with chronic pain><pragmatic effectiveness trial><pragmatic randomized trial><pragmatic trial><preparations><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><randomisation><randomization><randomized control trial><randomly assigned><reach, efficacy, adoption, implementation, and maintenance><safety outcomes><secondary outcome><social><team-based care><treatment as usual><treatment planning><usual care><well-being><wellbeing><whole health><whole person health>

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Miguel Angel Lujan Perez

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Exploratory lead · 16/100

Active award

$249,000

FY 2026

Project Title

Postpartum Neurobiological Sequelae of Prescription Opioid Use During Pregnancy

Grant Number:

4R00DA060209-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

11/30/2028

Project Abstract

PROJECT SUMMARY Pregnancy is a critical period for brain development, and drug use during this time disrupts ontogenic trajectories. During the last decade, the use of prescription opioids during pregnancy has reached notably high rates (14- 22%) in the United States. While previous research has foc...

Research Terms

<12-20 years old><Adolescence><Affect><Attention><Behavior><Behavioral><Birth><Brain><Brain Nervous System><Caring><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cues><Development><Dihydrohydroxycodeinone><Dopamine><Drug usage><Drugs><Economic Models><Electrophysiology><Electrophysiology (science)><Encephalon><Endocrine><Epidemiology><Exhibits><Exposure to><Female><Fiber><Gestation><Goals><Hydroxytyramine><Hypothalamic structure><Hypothalamus><Image><Incentives><Institution><Intracellular Communication and Signaling><Lactation><Late pregnancy><Learning><Life><Link><Maternal Mortality><Mediating><Medication><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mentors><Methods><Mice><Mice Mammals><Modeling><Mothers><Motivation><Murine><Mus><Nerve Cells><Nerve Transmitter Substances><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neurons><Neuropeptides><Neurophysiology / Electrophysiology><Neurotransmitters><Nulliparas><Nulliparity><Nulliparous><Ocytocin><Opiate Receptors><Opiates><Opioid><Opioid Receptor><Outcome><Overdose><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><Oxytocin><Oxytocin Receptor><Parturition><Pathway interactions><Pharmaceutical Preparations><Pharmacologic Actions><Phase><Photometry><Postpartum Period><Pregnancy><Pregnant Women><Process><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Recombinant Oxytocin><Reinforcement Schedule><Research><Research Proposals><Rewards><Risk><Risk Factors><Role><Roxicodone><Saccharose><Self Administered><Self Administration><Signal Transduction><Signal Transduction Systems><Signaling><Stimulus><Structure><Substance abuse problem><Sucrose><Synapses><Synaptic><Time><Training><United States><Ventral Tegmental Area><Viral Genetics><Work><abuse liability><abuse of substances><abuse potential><adolescence (12-20)><behavioral economics><biological signal transduction><brain circuitry><critical period><death among pregnant><death during pregnancy><design><designing><developmental><drug abuse vulnerability><drug reward><drug use><drug/agent><electrophysiological><endogenous opiate><endogenous opioids><epidemiologic><epidemiological><expectant mother><expectant women><expecting mother><expecting women><experience><experiment><experimental research><experimental study><experiments><genetic approach><genetic strategy><gestational opioid use><hypothalamic><imaging><in utero><in vivo><individuals who are pregnant><lactating><lactational><licit opioid><maternal death><mental illness><mesolimbic dopamine system><mesolimbic system><mortality during pregnancy><mortality in pregnancy><neural><neural circuit><neural circuitry><neurobehavioral><neurobiological><neurobiological mechanism><neurocircuitry><neuroeconomics><neuronal><neuronal excitability><novel><obstetric mortality><offspring><opiate abuse><opiate consumption><opiate drug abuse><opiate drug use><opiate exposure><opiate intake><opiate medication><opiate tolerance><opiate use><opiate use in pregnancy><opioid abuse><opioid consumption><opioid drug abuse><opioid drug use><opioid exposure><opioid habituation><opioid intake><opioid medication><opioid tolerance><opioid use><opioid use in pregnancy><opioids during pregnancy><opioids in pregnancy><opoid use during pregnancy><optogenetics><outcome prediction><overdose death><overdose fatalities><patch clamp><pathway><people who are pregnant><post-partum><postsynaptic><pregnancy associated death><pregnancy associated maternal death><pregnancy associated mortality><pregnancy death><pregnancy mortality><pregnancy related death><pregnancy related maternal death><pregnancy related mortality><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal opioid use><prescribed opiate><prescribed opioid><prescription opiate><prescription opioid><psychiatric illness><psychological disorder><pup><remifentanil><response><reward processing><social role><substance abuse><synapse><synaptic circuit><synaptic circuitry><those who are pregnant><tolerance to opiates><tool><ventral tegmentum><virus genetics><vulnerability to drug abuse><women who are pregnant><♀>

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Brittany Estelle Givens Rassoolkhani

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Exploratory lead · 16/100

Active award

$74,947

FY 2026

Project Title

In situ forming implant drug delivery for non-addictive post-operative analgesia

Grant Number:

5R03EB037115-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/10/2025

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY The opioid crisis in the United States resulted in over 100,000 overdose deaths in 2022. Reducing opioid prescriptions, particularly for acute pain, is crucial for minimizing substance use disorders. However, current alternatives for pain management are insufficient, leaving opioids ...

Research Terms

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Nikita Gupta

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Exploratory lead · 16/100

Active award

$74,947

FY 2026

Project Title

In situ forming implant drug delivery for non-addictive post-operative analgesia

Grant Number:

5R03EB037115-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/10/2025

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY The opioid crisis in the United States resulted in over 100,000 overdose deaths in 2022. Reducing opioid prescriptions, particularly for acute pain, is crucial for minimizing substance use disorders. However, current alternatives for pain management are insufficient, leaving opioids ...

Research Terms

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James Zach Hilt

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Exploratory lead · 16/100

Active award

$74,947

FY 2026

Project Title

In situ forming implant drug delivery for non-addictive post-operative analgesia

Grant Number:

5R03EB037115-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/10/2025

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY The opioid crisis in the United States resulted in over 100,000 overdose deaths in 2022. Reducing opioid prescriptions, particularly for acute pain, is crucial for minimizing substance use disorders. However, current alternatives for pain management are insufficient, leaving opioids ...

Research Terms

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ALANA C. CONTI

JOHN D DINGELL VA MEDICAL CENTER, DETROIT, MI

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Novel Intervention for TBI-induced Opioid Seeking

Grant Number:

5I01RX004567-03

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

11/1/2023

End Date:

10/31/2027

Project Abstract

Of the more than 300,000 service personnel that have sustained traumatic brain injury (TBI) due to recent conflicts, 70-80% are treated with opioids for post-injury symptoms. TBI-injured Veterans clinically managed for these symptoms that include chronic pain, are more likely to receive opioid-based...

Research Terms

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Amy S B Bohnert

VETERANS HEALTH ADMINISTRATION, ANN ARBOR, MI

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Diagnosing and Treating Veterans with Chronic Pain and Opioid Misuse

Grant Number:

5I01HX003411-05

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

1/1/2022

End Date:

5/31/2026

Project Abstract

Background: As many as 30% of the ~10 million Americans prescribed long-term opioid therapy (LTOT) are estimated to misuse opioids. Receiving LTOT is associated with opioid-related harms, and misuse leads to an increase in the dose consumed and other risky behavior, further worsening outcomes. Howev...

Research Terms

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Pooja Lagisetty

VETERANS HEALTH ADMINISTRATION, ANN ARBOR, MI

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Diagnosing and Treating Veterans with Chronic Pain and Opioid Misuse

Grant Number:

5I01HX003411-05

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

1/1/2022

End Date:

5/31/2026

Project Abstract

Background: As many as 30% of the ~10 million Americans prescribed long-term opioid therapy (LTOT) are estimated to misuse opioids. Receiving LTOT is associated with opioid-related harms, and misuse leads to an increase in the dose consumed and other risky behavior, further worsening outcomes. Howev...

Research Terms

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BRIAN D STEMPER

CLEMENT J. ZABLOCKI VA MEDICAL CENTER, MILWAUKEE, WI

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

TBI and opioid interactions in addiction-related outcomes

Grant Number:

5I01RX004768-02

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

11/1/2024

End Date:

10/31/2028

Project Abstract

PROJECT SUMMARY Numerous clinical studies demonstrate correlations between traumatic brain injury (TBI) and substance abuse, and it has been estimated that 10-20% of patients develop a new diagnosis of substance use disorder after TBI. Among all drugs, opioids had the highest increase in incidence, ...

Research Terms

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STEFAN G KERTESZ

BIRMINGHAM VA MEDICAL CENTER, BIRMINGHAM, AL

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Clinical context of SuicIde following OPIOID transitionS in Veterans, CSI:OPIOIDS-V

Grant Number:

5I01HX003407-04

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2022

End Date:

9/30/2026

Project Abstract

Background: Opioid prescribing has declined 64% between 2012 and 2020 in the Veterans Administration (VA),1 with high dose prescriptions declining 77%. Although this change likely will prevent prescription-related harm to Veterans, some reports signal adverse events - events that are not well unders...

Research Terms

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Corey J Hayes

CENTRAL ARKANSAS VETERANS HLTHCARE SYS, NORTH LITTLE ROCK, AR

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Data to Clinical Action: Using Predictive Analytics to Improve Care of Veterans with Opioid Use Disorder

Grant Number:

5IK2HX003358-04

Activity Code:

IK2

Mechanism:

Other

Agency:

VA

Start Date:

4/1/2022

End Date:

3/31/2027

Project Abstract

Background. Medication for opioid use disorder (MOUD) prevents overdoses and improves mortality in Veterans with OUD, but retention on MOUD is critical for achieving those clinical endpoints. Only 50% of Veterans are retained on MOUD at 6-months post-MOUD initiation. Poor engagement in additional ne...

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James E Zadina

SOUTHEAST LOUISIANA VETERANS HEALTH CARE, NEW ORLEANS, LA

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Development of Glycosylated Endomorphin Analogs with Low Abuse Liability for Treatment of Pain.

Grant Number:

5I01BX006167-03

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

1/1/2024

End Date:

12/31/2027

Project Abstract

Project Summary/Abstract Opioids acting at the mu opioid receptor (MOR) remain the gold standard for treatment of moderate to severe pain relief, but their use is limited by serious side effects, particularly abuse liability. The opioid epidemic has grown steadily in the past three decades, resulti...

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Wei Duan-Porter

MINNEAPOLIS VA MEDICAL CENTER, MINNEAPOLIS, MN

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

ECCO - Evaluation of Outcomes Associated with Community Care Prescribed Opioids

Grant Number:

5I01HX003224-04

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

3/1/2023

End Date:

2/28/2027

Project Abstract

Background: Starting in 2013, VA's Opioid Safety Initiative expanded resources for pain management and successfully reduced high-risk opioid prescriptions. MISSION Act expansion of VA Community Care (CC) includes authorization for CC providers to prescribe opioids for outpatient treatment of acute a...

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Alan Taylor Kelley

VA SALT LAKE CITY HEALTHCARE SYSTEM, SALT LAKE CITY, UT

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Patient-centered Quality Measurement for Opioid Use Disorder

Grant Number:

5IK2HX003531-02

Activity Code:

IK2

Mechanism:

Other

Agency:

VA

Start Date:

8/1/2024

End Date:

7/31/2029

Project Abstract

BACKGROUND: Delivery of evidence-based treatment for opioid use disorder (OUD)—especially medication treatment (MOUD)—reduces morbidity and mortality and is the bedrock of OUD care. Yet fewer than half of Veterans with OUD receive MOUD, and up to half who initiate treatment do not remain in treatmen...

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Jessica Jasmine Wyse

PORTLAND VA MEDICAL CENTER, PORTLAND, OR

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Predictors and Processes of Early Buprenorphine Discontinuation

Grant Number:

5I01HX003745-03

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2023

End Date:

3/30/2028

Project Abstract

Background: Buprenorphine and other medications for opioid use disorder (MOUD) are recommended as standard of care in the treatment of opioid use disorder (OUD) and associated with positive health and addiction-related outcomes.31,32 Although observational research suggests that buprenorphine treatm...

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Eric Schnell

PORTLAND VA MEDICAL CENTER, PORTLAND, OR

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Enkephalin-mediated hippocampal circuit disinhibition after traumatic brain injury

Grant Number:

5I01BX006921-02

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

1/1/2025

End Date:

12/31/2028

Project Abstract

Background and Innovation: Post-traumatic epilepsy is a potentially devastating consequence of head injury in Veterans that is often resistant to medical treatment. Post-traumatic epilepsy is associated with numerous functional changes in the hippocampus, a region of the brain that is frequently th...

Research Terms

<5-Methionine Enkephalin><Acquired brain injury><Acute><Affect><Ammon Horn><Animals><Assay><Behavior><Bioassay><Biological Assay><Biosensor><Body Tissues><Brain><Brain Injuries><Brain Nervous System><Brain Trauma><Brain region><Cell Communication and Signaling><Cell Signaling><Cerebrospinal Fluid><Convulsants><Cornu Ammonis><Craniocerebral Injuries><Craniocerebral Trauma><DNA Recombination><Data><Dentate Fascia><Development><Digenic Acid><Disinhibition><EEG><Electroencephalogram><Electroencephalography><Electrophysiology><Electrophysiology (science)><Elements><Encephalon><Enkephalins><Epilepsy><Epileptic Seizures><Epileptics><Epileptogenesis><Exhibits><Fascia Dentata><Future><Gene Deletion><Gene Modified><Genes><Genetic><Genetic Recombination><Glutamates><Goals><Gyrus Dentatus><Head Injuries><Head Trauma><Health><Health Care><Hippocampus><History><Human><In Situ Hybridization><Incidence><Individual><Injury><Intracellular Communication and Signaling><Investigation><KO mice><Kainic Acid><Knock-out Mice><Knockout Mice><L-Glutamate><Learning><Mediating><Medical><Messenger RNA><Met(5)-Enkephalin><Met-Enkephalin><Methionine Enkephalin><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Transmitter Substances><Nerve Unit><Neural Cell><Neurocyte><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Neurotransmitters><Null Mouse><Opiate Peptides><Opiates><Opioid><Opioid Peptide><Outcome><Pain><Painful><Pathogenesis><Pathway interactions><Penetrating Cranial Trauma><Penetrating Craniocerebral Trauma><Penetrating Head Injuries><Penetrating Head Trauma><Peptides><Physiologic><Physiological><Post-Traumatic Epilepsy><Post-Traumatic Seizure Disorder><Predisposition><Production><Recombination><Recording of previous events><Recurrence><Recurrent><Resistance><Risk><Rodent><Rodentia><Rodents Mammals><Role><Seizure Disorder><Seizures><Seminal><Series><Severities><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Staining method><Stains><Stimulus><Structure><Susceptibility><Synapses><Synaptic><Tamoxifen><Testing><Therapeutic><Time><Tissues><Translations><Traumatic Brain Injury><Traumatic Epilepsy><Upregulation><Veterans><Work><acquired epilepsy><addiction><addictive disorder><axon signaling><axon-glial signaling><axonal signaling><biological sensor><biological signal transduction><brain damage><brain-injured><cerebral spinal fluid><controlled cortical impact><dentate gyrus><develop therapy><developmental><effective therapy><effective treatment><electrophysiological><endogenous opiate><endogenous opioids><epilepsia><epileptogenic><experiment><experimental research><experimental study><experiments><gene deletion mutation><gene modification><genetically modified><glia signaling><glial signaling><glutamatergic><granule cell><hippocampal><histories><improved><improved outcome><in situ Hybridization Genetics><in situ Hybridization Staining Method><in vivo><injuries><innovate><innovation><innovative><insight><intervention design><intervention development><later in life><later life><mRNA><military veteran><motivated behavior><mouse model><murine model><nerve signaling><neural circuit><neural circuitry><neural signaling><neurocircuitry><neuronal><neuronal circuit><neuronal circuitry><neuronal signaling><neurotransmission><novel><opiate consumption><opiate drug use><opiate intake><opiate use><opioid consumption><opioid drug use><opioid growth factor><opioid intake><opioid use><pathway><prevent><preventing><pro-enkephalin><proenkephalin><resistant><social role><spinal fluid><synapse><synapse function><synapse inhibition><synaptic circuit><synaptic circuitry><synaptic function><synaptic inhibition><therapy design><therapy development><tissue fixing><tool><translation><traumatic brain damage><treatment design><treatment development><veteran population><water maze>

View Full Project Details on NIH Reporter

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John A Wemmie

IOWA CITY VA MEDICAL CENTER, IOWA CITY, IA

Exploratory lead · 10/100

Active award

$0

FY 2026

Project Title

Investigating a novel regulatory pathway for opioid-induced synaptic plasticity and behavior

Grant Number:

5I01BX004440-07

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2019

End Date:

9/30/2027

Project Abstract

The United States is in the midst of an opioid epidemic and risk is especially high in veterans. Current therapies consist mainly of alternative opioids, but their efficacy is limited. Thus, new treatments for pain and addiction are in high demand. Improved knowledge of the mechanisms underlying opi...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

SHUANGLIN HAO

MIAMI VA HEALTH CARE SYSTEM, MIAMI, FL

Exploratory lead · 10/100

Active award

$0

FY 2026

Project Title

The molecular mechanisms of astrocytes-neurons interaction in the morphine use disorder

Grant Number:

5I01BX005114-04

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2022

End Date:

9/30/2026

Project Abstract

Opioid use disorder (OUD) has substantial negative consequences on veterans' mental and physical health, work performance, housing status, and social function. Opioid drug abuse has reached an epidemic level in the United States. There is an increased risk of overdose death with higher daily opioid ...

Research Terms

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