Jyrki Ahveninen

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$824,728

FY 2026

Project Title

Characterizing intracortical feedforward and feedback sensory processes in ASD

Grant Number:

1R01MH139643-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/25/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Autism spectrum disorder (ASD) is a neurodevelopmental disorder long associated with functional connectivity abnormalities that are widespread throughout the brain. Despite countless studies on the topic, no single unifying model of functional connectivity abnormalities in ASD has e...

Research Terms

<21 year old><21 years of age><21+ years old><ASD><Address><Adult><Adult Human><Age><Area><Attention><Auditory><Auditory Cortex><Auditory area><Autism><Autistic Disorder><Back><Behavior><Behavior assessment><Biological Markers><Brain><Brain Nervous System><Characteristics><Complex><Data><Disease><Disorder><Dorsum><Early Infantile Autism><Encephalon><Experimental Designs><Failure><Feedback><Functional MRI><Functional Magnetic Resonance Imaging><Heterogeneity><Human><Individual><Infantile Autism><Kanner's Syndrome><Light><Link><MEG imaging><Magnetoencephalography><Maps><Measures><Methodology><Methods><Modeling><Modern Man><Msec><Neurodevelopmental Disorder><Neurological Development Disorder><Outcome><Participant><Pattern><Phenotype><Photoradiation><Research><Research Design><Resolution><Sensory><Sensory Process><Severities><Study Type><Symptoms><Techniques><Testing><Theoretic Models><Theoretical model><Time><Visual><Work><adulthood><age 21><age 21 years><ages><auditory processing><autism attributes><autism indicator><autism model><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><behavioral assessment><bio-markers><biologic marker><biomarker><cohort><design><designing><experiment><experimental research><experimental study><experiments><fMRI><magnetoencephalogram><magnetoencephalographic imaging><millimeter><millisecond><model of autism spectrum disorder><multi-modal neuro-imaging><multi-modality><multimodal neuroimaging><multimodality><neural><neural mechanism><neurodevelopmental disease><neuromechanism><neurophysiological><neurophysiology><neuropsychiatric><neuropsychiatry><new approaches><new technology><non-human primate><nonhuman primate><novel><novel approaches><novel strategies><novel strategy><novel technologies><perceptual stimulus><physicochemical phenomena related to the senses><resolutions><response><sensory feedback><sensory input><sensory stimulus><stem><study design><temporal measurement><temporal resolution><theories><time measurement><translational opportunities><translational potential><twenty-one year old><twenty-one years of age>

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Tal Kenet

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$824,728

FY 2026

Project Title

Characterizing intracortical feedforward and feedback sensory processes in ASD

Grant Number:

1R01MH139643-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/25/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Autism spectrum disorder (ASD) is a neurodevelopmental disorder long associated with functional connectivity abnormalities that are widespread throughout the brain. Despite countless studies on the topic, no single unifying model of functional connectivity abnormalities in ASD has e...

Research Terms

<21 year old><21 years of age><21+ years old><ASD><Address><Adult><Adult Human><Age><Area><Attention><Auditory><Auditory Cortex><Auditory area><Autism><Autistic Disorder><Back><Behavior><Behavior assessment><Biological Markers><Brain><Brain Nervous System><Characteristics><Complex><Data><Disease><Disorder><Dorsum><Early Infantile Autism><Encephalon><Experimental Designs><Failure><Feedback><Functional MRI><Functional Magnetic Resonance Imaging><Heterogeneity><Human><Individual><Infantile Autism><Kanner's Syndrome><Light><Link><MEG imaging><Magnetoencephalography><Maps><Measures><Methodology><Methods><Modeling><Modern Man><Msec><Neurodevelopmental Disorder><Neurological Development Disorder><Outcome><Participant><Pattern><Phenotype><Photoradiation><Research><Research Design><Resolution><Sensory><Sensory Process><Severities><Study Type><Symptoms><Techniques><Testing><Theoretic Models><Theoretical model><Time><Visual><Work><adulthood><age 21><age 21 years><ages><auditory processing><autism attributes><autism indicator><autism model><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><behavioral assessment><bio-markers><biologic marker><biomarker><cohort><design><designing><experiment><experimental research><experimental study><experiments><fMRI><magnetoencephalogram><magnetoencephalographic imaging><millimeter><millisecond><model of autism spectrum disorder><multi-modal neuro-imaging><multi-modality><multimodal neuroimaging><multimodality><neural><neural mechanism><neurodevelopmental disease><neuromechanism><neurophysiological><neurophysiology><neuropsychiatric><neuropsychiatry><new approaches><new technology><non-human primate><nonhuman primate><novel><novel approaches><novel strategies><novel strategy><novel technologies><perceptual stimulus><physicochemical phenomena related to the senses><resolutions><response><sensory feedback><sensory input><sensory stimulus><stem><study design><temporal measurement><temporal resolution><theories><time measurement><translational opportunities><translational potential><twenty-one year old><twenty-one years of age>

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LAUREN KENWORTHY

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$791,853

FY 2026

Project Title

A longitudinal study identifying psychological and service delivery targets to improve daily living skills and quality of life outcomes among autistic youth exiting high school

Grant Number:

5R01MH133838-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Approximately 1 million autistics will turn 18 in the next decade, many without the skills they need to achieve the quality-of-life that they and their families’ desire. Without effective supports, autistic youth struggle with daily living skills, regardless of their intellectual abilities. Daily li...

Research Terms

<12-20 years old><21+ years old><ASD><Access to Care><Accounting><Address><Adolescence><Adult><Adult Human><Advocate><Autism><Autistic Disorder><Automobile Driving><Care Givers><Caregiver instruction><Caregivers><Childhood><Communities><Data><Development><Documentation><Early Infantile Autism><Economic Income><Economical Income><Employment><Employment Opportunities><Enrollment><Ensure><Environmental Factor><Environmental Risk Factor><Ethnic Origin><Ethnicity><Family><Happiness><Health Care><Health Instruction><Health Promotion><Health Services Accessibility><Health Tutoring><Health education><Home><Income><Independent Living><Individual><Infantile Autism><Instruction><Insurance><Intervention><Kanner's Syndrome><Knowledge><Legal><Link><Long-term prospective studies><Longitudinal Studies><Longitudinal Surveys><Mid-Atlantic Region><Middle Atlantic States><Neighborhoods><Outcome><Participant><Play><Policies><Population><Privatization><Productivity><Psychological Factors><Public Health><QOL><QOL improvement><Quality of life><Race><Races><Research><Research Priority><Research Resources><Resources><Role><Salutogenesis><Sampling><Sampling Biases><Schools><Secondary Schools><Self Care><Self Determination><Service provision><Services><Site><Societal Factors><Societies><System><Talents><Teen><Teenagers><Testing><Time><United States><Visit><Work><Youth><Youth 10-21><access disparities><access to health services><access to services><access to treatment><accessibility disparities><accessibility to health services><adolescence (12-20)><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age group><autism spectral disorder><autism spectrum disorder><autistic><autistic adolescent><autistic adult><autistic individuals><autistic people><autistic spectrum disorder><autistic youth><availability of services><care access><care giver education><care giver instruction><care giver training><caregiver education><caregiver training><community living><developmental><disparities in access><driving><early adulthood><emerging adult><enroll><environmental risk><evaporation><executive control><executive function><experience><health service access><health services availability><high school><homes><improved><improvements in QOL><improvements in quality of life><incomes><independent self care><indexing><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><inequality in access><inequity in access><inequity in accessibility><intervention delivery><long-term study><longitudinal outcome studies><longitudinal research study><longitudinal, prospective study><non-speaking><non-verbal><non-vocal><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><personal care><prevent><preventing><promoting health><psychologic><psychological><quality of life improvement><racial><racial background><racial origin><recruit><secondary education><service availability><service delivery><service engagement><services engagement><sex><site targeted delivery><skills><social engagement><social health determinants><social involvement><social participation><social role><targeted delivery><teen years><teenage><treatment access><youth age><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder>

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BENJAMIN YERYS

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$791,853

FY 2026

Project Title

A longitudinal study identifying psychological and service delivery targets to improve daily living skills and quality of life outcomes among autistic youth exiting high school

Grant Number:

5R01MH133838-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Approximately 1 million autistics will turn 18 in the next decade, many without the skills they need to achieve the quality-of-life that they and their families’ desire. Without effective supports, autistic youth struggle with daily living skills, regardless of their intellectual abilities. Daily li...

Research Terms

<12-20 years old><21+ years old><ASD><Access to Care><Accounting><Address><Adolescence><Adult><Adult Human><Advocate><Autism><Autistic Disorder><Automobile Driving><Care Givers><Caregiver instruction><Caregivers><Childhood><Communities><Data><Development><Documentation><Early Infantile Autism><Economic Income><Economical Income><Employment><Employment Opportunities><Enrollment><Ensure><Environmental Factor><Environmental Risk Factor><Ethnic Origin><Ethnicity><Family><Happiness><Health Care><Health Instruction><Health Promotion><Health Services Accessibility><Health Tutoring><Health education><Home><Income><Independent Living><Individual><Infantile Autism><Instruction><Insurance><Intervention><Kanner's Syndrome><Knowledge><Legal><Link><Long-term prospective studies><Longitudinal Studies><Longitudinal Surveys><Mid-Atlantic Region><Middle Atlantic States><Neighborhoods><Outcome><Participant><Play><Policies><Population><Privatization><Productivity><Psychological Factors><Public Health><QOL><QOL improvement><Quality of life><Race><Races><Research><Research Priority><Research Resources><Resources><Role><Salutogenesis><Sampling><Sampling Biases><Schools><Secondary Schools><Self Care><Self Determination><Service provision><Services><Site><Societal Factors><Societies><System><Talents><Teen><Teenagers><Testing><Time><United States><Visit><Work><Youth><Youth 10-21><access disparities><access to health services><access to services><access to treatment><accessibility disparities><accessibility to health services><adolescence (12-20)><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age group><autism spectral disorder><autism spectrum disorder><autistic><autistic adolescent><autistic adult><autistic individuals><autistic people><autistic spectrum disorder><autistic youth><availability of services><care access><care giver education><care giver instruction><care giver training><caregiver education><caregiver training><community living><developmental><disparities in access><driving><early adulthood><emerging adult><enroll><environmental risk><evaporation><executive control><executive function><experience><health service access><health services availability><high school><homes><improved><improvements in QOL><improvements in quality of life><incomes><independent self care><indexing><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><inequality in access><inequity in access><inequity in accessibility><intervention delivery><long-term study><longitudinal outcome studies><longitudinal research study><longitudinal, prospective study><non-speaking><non-verbal><non-vocal><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><personal care><prevent><preventing><promoting health><psychologic><psychological><quality of life improvement><racial><racial background><racial origin><recruit><secondary education><service availability><service delivery><service engagement><services engagement><sex><site targeted delivery><skills><social engagement><social health determinants><social involvement><social participation><social role><targeted delivery><teen years><teenage><treatment access><youth age><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder>

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Edmund Au

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$791,553

FY 2026

Project Title

Programs for generating inhibitory interneuron diversity and connectivity

Grant Number:

5R01MH133381-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/20/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY: Inhibitory interneurons comprise a diverse class of neurons of indisputably high biomedical importance. Interneuron dysfunctions are linked to neuropsychiatric disorders such as autism and schizophrenia and are also implicated in epilepsy and neurodegeneration. Cortical interneurons are bor...

Research Terms

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Kristin Kay Baldwin

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$791,553

FY 2026

Project Title

Programs for generating inhibitory interneuron diversity and connectivity

Grant Number:

5R01MH133381-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/20/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY: Inhibitory interneurons comprise a diverse class of neurons of indisputably high biomedical importance. Interneuron dysfunctions are linked to neuropsychiatric disorders such as autism and schizophrenia and are also implicated in epilepsy and neurodegeneration. Cortical interneurons are bor...

Research Terms

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Daniel Brian Campbell

HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES, EAST LANSING, MI

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$790,980

FY 2026

Project Title

Epigenetic Control of High Confidence Autism Spectrum Disorder Genes

Grant Number:

1R01ES036522-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Description Autism spectrum disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by social communication deficits and repetitive behaviors with restricted interests. The lifelong social and behavioral challenges, along with a lack of therapeutic agents designed to t...

Research Terms

<1st trimester><20p12><2nd trimester><ASD><Air Pollutants><Air Pollution><Autism><Autistic Disorder><Autopsy><Behavioral><Biological><Brain><Brain Nervous System><Cell Body><Cell Line><CellLine><Cells><Cerebrum><Chromosomes><Complex><Confocal Microscopy><DNA Helicases><DNA Unwinding Proteins><DNA mutation><DNA unwinding enzyme><DNA-Binding Proteins><Data><Depakote><Depakote ER><Development><Diagnosis><Divalproex><Dose><Early Infantile Autism><Early Placental Phase><Ecologic Monitoring><Ecological Monitoring><Ecological impact><Elements><Encephalon><Environmental Exposure><Environmental Factor><Environmental Impact><Environmental Monitoring><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epistasis><Epistatic Deviation><Family><Female><First Pregnancy Trimester><First Trimester><Functional RNA><GWA study><GWAS><Gene Expression><Gene Inactivation><Gene Silencing><Gene Transcription><Gene variant><Gene x Environment Interaction><Genes><Genetic><Genetic Change><Genetic Epistasis><Genetic Risk><Genetic Transcription><Genetic defect><Genetic mutation><Genetic predisposing factor><Genotype><Goals><GxE interaction><Harvest><Health Care><Heritability><Human><Individual><Induced DNA Alteration><Induced Mutation><Induced Sequence Alteration><Infantile Autism><Interaction Deviation><Intervention><Kanner's Syndrome><Knowledge><Link><Midtrimester><Modeling><Modern Man><Molecular><Molecular Target><Mutant Strains Mice><Mutation><Neural Development><Neural Stem Cell><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Differentiation><Noncoding RNA><Nontranslated RNA><Organoids><Outcome><PM2.5><Paper><Particulate Matter><Pathway interactions><Phenotype><Physiology><Prevalence><Publishing><RNA Expression><Research><Risk Factors><Risk-associated variant><Second Pregnancy Trimester><Second Trimester><Strains Cell Lines><Symptoms><Synapses><Synaptic><Testing><Therapeutic Agents><Time><Transcription><Transfection><Untranslated RNA><Valproic Acid><allelic variant><assess effectiveness><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic people><autistic spectrum disorder><biologic><cell type><cerebral><critical period><cultured cell line><derepression><design><designing><determine effectiveness><developmental><disease risk><disorder risk><effectiveness assessment><effectiveness evaluation><environment effect on gene><environmental risk><environmental testing><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><epistatic interaction><epistatic relationship><evaluate effectiveness><examine effectiveness><exome sequencing><exome-seq><experiment><experimental research><experimental study><experiments><exposed human population><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fine particles><fine particulate matter><flexibility><flexible><functional genomics><gene environment interaction><gene x gene interaction><genetic epistases><genetic risk factor><genetic variant><genome mutation><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic tools><genomic variant><global gene expression><global transcription profile><helicase><human exposure><iPS><iPSC><iPSCs><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inherited factor><interest><loss of function mutation><low-frequency mutation><male><mouse mutant><necropsy><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopment><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><noncoding><novel><overexpress><overexpression><patch clamp><pathway><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><postmortem><progenitor and neural stem cells><programs><rare allele><rare mutation><rare variant><repetitive behavior><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scRNA sequencing><scRNA-seq><sex><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social><social communication><synapse><transcriptional silencing><transcriptome><whole genome association analysis><whole genome association study><♀><♂>

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Brian James O'Roak

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$786,439

FY 2026

Project Title

Characterizing patient-specific TBR1 mutations: Understanding a master regulator of autism risk

Grant Number:

2R01MH113926-06A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2017

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Over the past decade, genetic studies focused on identifying de novo mutations have unlocked ~100-200 new mid to high-confidence autism risk genes. These mutations are likely highly penetrant and provide a biologic handle to begin clarifying the molecular, cellular, and circ...

Research Terms

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Eric M Morrow

BROWN UNIVERSITY, PROVIDENCE, RI

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$786,292

FY 2026

Project Title

Neurodevelopmental mechanisms in 17q12 CNV disorders and autism

Grant Number:

5R01MH137004-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Copy number variants (CNVs) are contiguous gene deletions or duplications that confer susceptibility to neuro- psychiatric and neurodevelopmental disorders (NDDs). Thereby, CNVs offer a powerful opportunity to investi- gate multigenic mechanisms in complex brain disease. Recent studi...

Research Terms

<21+ years old><ASD><Adult><Adult Human><Agonist><Ammon Horn><Anterior><Autism><Autistic Disorder><Basal Transcription Factor><Basal transcription factor genes><Behavior><Behavioral><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Cations><Cell Body><Cell Line><Cell model><CellLine><Cells><Cellular model><Clinical Research><Clinical Study><Code><Coding System><Collaborations><Complex><Copy Number Polymorphism><Cornu Ammonis><Craniofacial Abnormalities><DNA mutation><Defect><Development><Disease><Disorder><Dysfunction><Early Infantile Autism><Embryo><Embryonic><Encephalon><Encephalon Diseases><Exhibits><Family><Fore-Brain><Forebrain><Foundations><Functional disorder><Gene Copy Number><Gene Deletion><Gene Dosage><Gene Duplication><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Transcription><Genetic Variation><Genetic defect><Genetic mutation><Genetic predisposing factor><Head><Heterogeneity><Hippocampus><Human><Impairment><In Vitro><Inbreeding><Induced pluripotent stem cell derived human neuron><Induced pluripotent stem cell derived neurons><Infantile Autism><International><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><KO mice><Kanner's Syndrome><Knock-out Mice><Knockout Mice><Knowledge><Leanness><Link><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methodology><Mice><Mice Mammals><Modern Man><Molecular><Molecular Analysis><Mouse Strains><Murine><Mus><Mutation><NMR Imaging><NMR Tomography><Neonatal><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neurons><Nuclear Magnetic Resonance Imaging><Null Mouse><Partner in relationship><Pathway interactions><Patients><Pattern><Phenotype><Physiopathology><Predisposition><Process><Prosencephalon><Proteins><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Reporter><Research><Research Resources><Resources><Risk Factors><Rodent><Rodentia><Rodents Mammals><Severities><Strains Cell Lines><Susceptibility><Testing><Therapeutic><Therapeutic Intervention><Thinness><Transcription><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activator/Coactivator><WNT Signaling Pathway><WNT signaling><Zeugmatography><adulthood><antagonism><antagonist><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior study><behavioral study><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><brain abnormalities><brain shape><combinatorial><copy number variant><copy number variation><craniofacial anomalies><craniofacial defects><craniofacial malformation><cultured cell line><developmental><experiment><experimental research><experimental study><experiments><gene deletion mutation><genetic risk factor><genome mutation><global gene expression><global transcription profile><hiPSC><hiPSC-derived neurons><hippocampal><human iPS><human iPSC><human iPSC-derived sensory neuron><human induced pluripotent cell><human induced pluripotent stem cell derived sensory neuron><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human progenitor><human stem cells><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSC-derived human neuron><iPSCs><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><inducible pluripotent cell><inducible pluripotent stem cell><inducible pluripotent stem cell derived human neuron><inducible pluripotent stem cell derived human sensory neuron><inherited factor><innovate><innovation><innovative><intervention therapy><mate><morphometry><mouse genetics><multidisciplinary><neural><neurodevelopment><neurodevelopmental disease><neuron development><neuronal><neuronal development><neurons derived from induced pluripotent stem cells><neurons differentiated from human induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><neuropsychiatric disease><neuropsychiatric disorder><novel><pathophysiology><pathway><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient-derived pluripotent stem cells><post-natal development><postnatal><postnatal development><progenitor cell model><progenitor model><programs><response to therapy><response to treatment><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><therapeutic response><therapy response><transcription factor><transcriptome><transcriptome sequencing><transcriptomic sequencing><translation strategy><translational approach><translational strategy><treatment response><treatment responsiveness>

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Peyman Golshani

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$771,758

FY 2026

Project Title

Unstable nucleus accumbens social representations in models of social behavioral dysfunction.

Grant Number:

5R01MH132736-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract: The social motivation/reward theory of autism spectrum disorder (ASD) outlines that individuals with autism tend not to pursue, engage or maintain social interactions because they find social interactions less rewarding than individuals without ASD. A major hypothesis is that traditional ...

Research Terms

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Weizhe Hong

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$771,758

FY 2026

Project Title

Unstable nucleus accumbens social representations in models of social behavioral dysfunction.

Grant Number:

5R01MH132736-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract: The social motivation/reward theory of autism spectrum disorder (ASD) outlines that individuals with autism tend not to pursue, engage or maintain social interactions because they find social interactions less rewarding than individuals without ASD. A major hypothesis is that traditional ...

Research Terms

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Jessica Jillian Walsh

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$750,391

FY 2026

Project Title

Neural mechanisms underlying sustained enhancement of sociability

Grant Number:

5R01MH136266-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/5/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Social behavior comprises multiple distinct types of interactions that play a critical role in reproduction, survival, and over-all well-being. Dysfunction of the serotonin system has long been associated with social deficits present in a host of psychiatric and neurodevelopmental di...

Research Terms

<3,4 methylenedioxymethamphetamine><5-HT><5-HT pathway><5-HT system><5-Hydroxytryptamine><5HT><ASD><Acute><Air Conditioning><Anxiety><Autism><Autistic Disorder><Basal Transcription Factor><Basal transcription factor genes><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chromatin><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Clinical><Corpus Striatum><Corpus striatum structure><DREADDs><Data><Development><Disease><Disorder><Dose><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Elements><Enteramine><Etiology><Fiber><Functional disorder><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Goals><Heterozygote><Hippophaine><Human><Impairment><Individual><Infantile Autism><Intervention><Intracellular Communication and Signaling><Kanner's Syndrome><Kinetics><MDMA><Maintenance><Mating Type Switching/Sucrose Nonfermenting Protein><Medial><Mediator><Mental Depression><Mental disorders><Mental health disorders><Methylenedioxymethamphetamine><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Mutate><N,alpha-dimethyl-1,3-benzodioxole-5-ethanamine><N-Methyl-3,4-methylenedioxyamphetamine><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Neurophysiology / Electrophysiology><Nucleus Accumbens><Patients><Personal Satisfaction><Photometry><Physiologic><Physiological><Physiology><Physiopathology><Play><Population><Prefrontal Cortex><Prevalence><Psychiatric Disease><Psychiatric Disorder><Receptor Protein><Regimen><Reproduction><Role><SSRI><SSRIs><SWI/SNF Complex><SWI/SNF Family Complex><Schizophrenia><Schizophrenic Disorders><Selective Serotonin Reuptake Inhibitor><Selective serotonin re-uptake inhibitor><Serotonergic System><Serotonin><Signal Transduction><Signal Transduction Systems><Signaling><Social Behavior><Speed><Striate Body><Striatum><System><Therapeutic><Therapeutic Effect><Transcription Factor Proto-Oncogene><Transcription factor genes><Work><autism model><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic people><autistic spectrum disorder><biological signal transduction><causation><chromatin modifier><chromatin remodeling><dementia praecox><depression><designer receptors exclusively activated by designer drugs><developmental><disease causation><ecstasy><effective therapy><effective treatment><electrophysiological><experience><heterozygosity><improved><in vivo><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><mental illness><model of autism spectrum disorder><mouse model><murine model><neural><neural adaptation><neural mechanism><neuroadaptation><neurodevelopmental disease><neuromechanism><neuronal><neuropsychiatric disease><neuropsychiatric disorder><new approaches><novel><novel approaches><novel strategies><novel strategy><optogenetics><pathophysiology><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><pre-clinical><preclinical><psychiatric illness><psychological disorder><receptor><schizophrenic><serotonergic pathway><serotonin pathway><serotonin reuptake inhibitor><serotonin system><side effect><social><social defects><social deficits><social disorders><social dysfunction><social role><sociobehavior><sociobehavioral><striatal><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><transcription factor><well-being><wellbeing>

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Smita Yadav

UNIVERSITY OF WASHINGTON, SEATTLE, WA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$727,411

FY 2026

Project Title

Kinase Dysfunction in Autism and Neurodevelopmental Disorders

Grant Number:

5R01MH130336-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Kinase signaling exquisitely orchestrates each step of neuronal development, beginning at neurogenesis to neuronal integration into functional synaptic networks. Through their highly specific substrate phosphorylation, protein kinases regulate neuronal growth, activity and their plasticity...

Research Terms

<3-D modeling><3D modeling><ASD><ATP-protein phosphotransferase><Amino Acids><Ammon Horn><Assay><Autism><Autistic Disorder><Binding><Bioassay><Biochemical><Biochemistry><Biologic Models><Biological><Biological Assay><Biological Chemistry><Biological Models><Biology><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Causality><Cell Communication and Signaling><Cell Signaling><Cell membrane><Cerebral cortex><Cornu Ammonis><Cytoplasmic Membrane><DNA mutation><Data><Development><Disease><Disorder><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Etiology><Functional disorder><Generalized Growth><Genes><Genetic Change><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic defect><Genetic mutation><Growth><Hereditary><Hippocampus><Human><Human Engineering><In Vitro><Induced pluripotent stem cell derived neurons><Infantile Autism><Inherited><Inositide Phospholipids><Inositol Phosphoglycerides><Inositol Phospholipids><Intracellular Communication and Signaling><Investigation><Kanner's Syndrome><Kinase Family Gene><Kinases><Lead><Lipid Binding><Liposomal><Liposomes><Macrocephaly><Macromolecular Structure><Mediating><Megacephaly><Megalocephaly><Membrane><Model System><Modeling><Modern Man><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Molecular Structure><Morphology><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neurons><Neuropathogenesis><Neurophysiology / Electrophysiology><Organoids><Pathogenesis><Pathway interactions><Pb element><Phosphatides><Phosphatidyl Inositol><Phosphatidylinositols><Phosphoinositides><Phospholipids><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Physiopathology><Plasma Membrane><Property><Protein Kinase><Protein Phosphorylation><Protein Truncation><Protein-Serine Kinase><Protein-Serine-Threonine Kinases><Protein-Threonine Kinase><Proteins><Proteomics><PtdIns><Recombinant DNA Technology><Research Proposals><Role><Serine Kinase><Serine-Threonine Kinases><Serine/Threonine Protein Kinase Gene><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single Crystal Diffraction><Spinal Column><Spine><Synapses><Synaptic><Testing><Threonine Kinase><Tissue Growth><Transphosphorylases><Vertebral column><X Ray Crystallographies><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray/Neutron Crystallography><Xray Crystallography><aminoacid><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><backbone><biologic><biological signal transduction><causation><chemical genetics><comparative><conformation><conformational><conformational state><conformationally><conformations><developmental><disease causation><electrophysiological><excitatory neuron><experiment><experimental research><experimental study><experiments><genetically engineered><genome mutation><glycogen synthase a kinase><heavy metal Pb><heavy metal lead><hiPSC><hippocampal><human disease><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human progenitor cell derived><human stem cell-derived><hydroxyalkyl protein kinase><iPS neurons><iPSC derived-neurons><iPSC technology><induced human pluripotent stem cells><induced pluripotent stem cell neurons><induced pluripotent stem cell technology><inhibitor><innovate><innovation><innovative><lipid bound><membrane structure><migration><mutant><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopmental disease><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuron development><neuron progenitors><neuronal><neuronal development><neuronal growth><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><neuropathologic><neuropathological><neuropathology><neuroprogenitor><ontogeny><pathophysiology><pathway><phospho-proteomics><phosphoproteomics><phosphorylase b kinase kinase><plasmalemma><progenitor and neural stem cells><progenitor cell model><progenitor model><reconstitute><reconstitution><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stem cell technology><structural biology><synapse><three-dimensional modeling>

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Kimberly R Tolias

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$718,600

FY 2026

Project Title

BAI Adhesion-GPCRs: Key Regulators of Synapse Development and Plasticity in Health and Disease

Grant Number:

5R01MH137505-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Development fashions 1011 neurons in the brain that form 1014 tightly regulated synaptic connections which un- derlie cognition and emotion. Numerous neuropsychiatric diseases arise from even small genetic perturbations or environmental insults affecting synapse development,...

Research Terms

<21+ years old><ASD><Adhesion Molecule><Adhesions><Adult><Adult Human><Affect><Ammon Horn><Astrocytes><Astrocytus><Astroglia><Autism><Autistic Disorder><Axon><BAI1><BAI1 gene><BAI2><BAI2 gene><BAI3><BAI3 gene><Binding><Biology><Bipolar Affective Psychosis><Bipolar Disorder><Brain><Brain Cancer><Brain Nervous System><Brain-Specific Angiogenesis Inhibitor 2><Brain-Specific Angiogenesis Inhibitor 3><Brain-specific Angiogenesis Inhibitor 1><C-terminal><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Communication and Signaling><Cell Signaling><Cell Surface Receptors><Cognition><Complex><Cornu Ammonis><Cues><Data><Dendrites><Development><Disease><Disorder><Dissociation><Early Infantile Autism><Emotions><Encephalon><Excitatory Synapse><Exhibits><Family><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G Protein-Coupled Receptor Signaling><G-Protein-Coupled Receptors><GPCR><GPCR Signaling><GTP Phosphohydrolases><GTPases><Generalized Growth><Genetic><Goals><Growth><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Health><Hippocampus><Human><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intracellular Communication and Signaling><KIAA0550><Kanner's Syndrome><Learning><Length><Ligand Binding><Ligands><Link><Malignant Tumor of the Brain><Malignant neoplasm of brain><Manic-Depressive Psychosis><Maps><Mediating><Membrane><Memory><Mental Depression><Mitochondria><Modeling><Modern Man><Molecular><Molecular Interaction><N-terminal><NH2-terminal><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neurons><Pathway interactions><Play><Portraits><Process><Property><Receptor Activation><Regulation><Reporting><Role><Schizophrenia><Schizophrenic Disorders><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Site><Structure><Synapses><Synaptic><Synaptic plasticity><Tail><Testing><Tissue Growth><adulthood><astrocytic glia><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><axon growth><axonal growth><biological signal transduction><bipolar affective disorder><bipolar disease><bipolar illness><bipolar mood disorder><cell adhesion protein><cognitive ability><cognitive performance><dementia praecox><depression><developmental><extracellular><guanosinetriphosphatase><hippocampal><human disease><intellectual and developmental disability><interdisciplinary approach><limited intellectual functioning><manic depressive disorder><manic depressive illness><member><membrane structure><mitochondrial><mood regulation><multidisciplinary approach><neurodevelopment><neuronal><neuropsychiatric disease><neuropsychiatric disorder><ontogeny><pathway><postsynaptic><presynaptic><response><rho G-Proteins><rho GTP-Binding Proteins><rho GTPases><rho Protein P21><rho Small GTP-Binding Proteins><schizophrenic><social role><synapse><synapse formation><synapse function><synaptic function><synaptogenesis><therapeutic target>

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Benjamin Brewster Risk

EMORY UNIVERSITY, ATLANTA, GA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$694,033

FY 2026

Project Title

Statistical approaches to improving functional connectivity estimates with an application to autism

Grant Number:

5R01MH129855-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Functional magnetic resonance imaging (fMRI) is used to estimate the correlations between brain regions. De- spite the many insights into brain function provided by fMRI, the ﬁeld is currently experiencing a reproducibility crisis. For instance, autism spectrum disorder (ASD) is thought to ...

Research Terms

<0-11 years old><ASD><Abscission><Address><Artifacts><Autism><Autistic Disorder><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Cell Communication and Signaling><Cell Signaling><Child><Child Youth><Childhood><Children (0-21)><Clip><Collection><Data><Data Set><Development><Diagnosis><Early Infantile Autism><Education><Educational aspects><Encephalon><Encephalon Diseases><Excision><Exclusion><Extirpation><Family><Formulation><Functional MRI><Functional Magnetic Resonance Imaging><Goals><Grant><Head><Impairment><Infantile Autism><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Learning><Linear Models><Literature><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Mediating><Mediation><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Methodology><Methods><Modeling><Morphologic artifacts><Motion><NMR Imaging><NMR Tomography><Negotiating><Negotiation><Nervous System Diseases><Nervous System Disorder><Neurodevelopmental Disorder><Neurologic><Neurologic Disorders><Neurological><Neurological Development Disorder><Neurological Disorders><Nuclear Magnetic Resonance Imaging><Participant><Probability><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Quality Control><Removal><Reporting><Reproducibility><Research><Rest><Running><Sampling><Sampling Biases><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Slide><Social Behavior><Social Interaction><Statistical Methods><Surgical Removal><Testing><Universities><Zeugmatography><autism spectral disorder><autism spectrum disorder><autistic children><autistic spectrum disorder><behavior measurement><behavioral measure><behavioral measurement><biological signal transduction><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cohort><develop software><develop therapy><developing computer software><developmental><experience><eye tracking><fMRI><improved><insight><intervention development><kids><mental illness><movie><neural><neural imaging><neuro-imaging><neurodevelopmental disease><neuroimaging><neurological disease><neurological imaging><novel><pediatric><psychiatric illness><psychological disorder><resection><sociobehavior><sociobehavioral><software development><statistic methods><theories><therapy development><tool><treatment development><visual tracking><youngster>

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Hirofumi Morishita

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$665,667

FY 2026

Project Title

Maturation of frontal cortico-thalamic circuitry in control of social behavior

Grant Number:

5R01MH118297-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/18/2019

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Impaired social processing is one of key hallmarks of many neurodevelopmental and psychiatric disorders including autism spectrum disorders (ASDs). As the social deficits tend to emerge during early childhood and adolescence, characterization of developmental trajectories is vastly important for und...

Research Terms

<12-20 years old><21+ years old><ASD><Address><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Alternative Therapies><Alternative intervention><Animals><Autism><Autistic Disorder><Behavior><Behavioral><Benzodiazepine Compounds><Benzodiazepines><Bp50><Brain region><CD40><CDW40><Cell Communication and Signaling><Cell Signaling><Data><Development><Disease><Disorder><Drug Therapy><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Female><Fiber><Funding><Genes><Genetic><Genetic Risk><Genetic predisposing factor><Housing><Image><Impairment><Infantile Autism><Intervention><Intracellular Communication and Signaling><Kanner's Syndrome><Link><MGC9013><Measures><Medial><Mental disorders><Mental health disorders><Mice><Mice Mammals><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Neurophysiology / Electrophysiology><Paraventricular Nucleus of Thalamus><Paraventricular Thalamic Nucleus><Partner in relationship><Pathway interactions><Pharmacological Treatment><Pharmacotherapy><Photometry><Prefrontal Cortex><Prevention><Psychiatric Disease><Psychiatric Disorder><Signal Transduction><Signal Transduction Systems><Signaling><Social Behavior><Social Controls><Social Interaction><Social Responsibility><Social isolation><Structure of paraventricular nucleus of thalamus><TNFRSF5><TNFRSF5 gene><Techniques><Testing><Thalamic structure><Thalamus><Tumor Necrosis Factor Receptor Superfamily Member 5 Gene><adolescence (12-20)><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><biological signal transduction><developmental><disease risk><disorder risk><drug intervention><drug treatment><early adolescence><early childhood><electrophysiological><experience><genetic risk factor><global gene expression><global transcription profile><imaging><in vivo><inherited factor><juvenile><juvenile human><later in life><later life><male><mate><mental illness><neurodevelopmental disease><neuronal><optogenetics><p50><patch clamp><pathway><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><prevent><preventing><psychiatric illness><psychological disorder><reward circuitry><social><social defects><social deficits><social disorders><social dysfunction><sociobehavior><sociobehavioral><thalamic><therapeutic target><transcriptome><♀><♂>

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Catherine Lord

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$651,373

FY 2026

Project Title

Family caregivers in later life: A longitudinal study of well-being and mental health in families of adults with autism and developmental disabilities

Grant Number:

5R01AG080599-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract This project aims to improve our ability to support the resilience of family caregivers of adults with autism and developmental disorders as the caregivers move into later life. Based on a 30 year longitudinal study that prospectively followed families from when their childr...

Research Terms

<0-11 years old><ASD><Address><Adult Children><Adult Daughters><Adult Offspring><Adult Sons><Affect><Age><Aggression><Aggressive behavior><Aging><Amentia><Anxiety><Autism><Autistic Disorder><Autistic young adult><Behavior><Behavioral><Belief><Biological><Biological Aging><Biological Function><Biological Process><Buffers><Burden on their caregivers><Care Givers><Caregiver Burden><Caregiver instruction><Caregiver well-being><Caregivers><Caring><Characteristics><Child><Child Development Disorders><Child Youth><Children (0-21)><Cognitive><Cognitive aging><Coping Skills><Data><Deceleration><Dementia><Development><Developmental Delay><Developmental Delay Disorders><Developmental Disabilities><Disease><Disorder><Early Infantile Autism><Economic Income><Economical Income><Education><Educational aspects><Emotional Depression><Event><Exposure to><Family><Family Care Giver><Family Caregiver><Financial Support><Future><Goals><Health><History><Home><Income><Independent Living><Infantile Autism><Interview><Kanner's Syndrome><Life><Link><Long-term prospective studies><Longitudinal Studies><Longitudinal Surveys><Measures><Mental Depression><Mental Health><Mental Hygiene><Modeling><Outcome><Patient Self-Report><Personal Satisfaction><Physical Function><Predictive Factor><Prospective Studies><Psychological Health><Questionnaires><Race><Races><Recording of previous events><Research><Research Resources><Resources><Retirement><Risk><Role><Sampling><Self-Report><Social Network><Social support><Specific Child Development Disorders><Specificity><Stress><Testing><Time><Work><accelerated aging><accelerated biological age><accelerated biological aging><accumulated exposure><accumulated long-term exposure><adult with ASD><adult with autism><adult with autism spectrum disorder><adult youth><adults on the autism spectrum><adults on the spectrum><age acceleration><ages><aggregate exposure><autism spectral disorder><autism spectrum disorder><autistic><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><biologic><biological process of age><build resilience><build resiliency><burden in caregivers><burden of their caregivers><burden on caregivers><care giver education><care giver instruction><care giver stress><care giver training><care giver well-being><care giver wellbeing><care giving><care giving burden><caregiver distress><caregiver education><caregiver stress><caregiver training><caregiver wellbeing><caregiving><caregiving burden><caregiving stress><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cognitive ability><cognitive change><cognitive function><coping><coping strategy><cumulative exposure><cumulative life exposure><cumulative long-term exposure><cumulative risk><demographics><depression><depression symptom><depressive><depressive symptoms><develop resilience><develop resiliency><developmental><developmental disease><developmental disorder><diaries><enhance resilience><enhance resiliency><externalizing behavior><facilitate resilience><financial aid><financial assistance><histories><homes><improve resilience><improve resiliency><improved><incomes><increase resilience><increase resiliency><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><kids><later in life><later life><life-course exposure><lifelong exposure><lifespan exposure><lifetime exposure><long-term study><longitudinal outcome studies><longitudinal research study><longitudinal, prospective study><older adult><older adulthood><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><prevent><preventing><promote resilience><promote resiliency><prospective><prospective research study><prospective survey><racial><racial background><racial origin><resilience><resilience development><resilient><retirements><social><social factors><social role><social support network><stress among caregiver><stress in caregiver><stress on caregiver><totality of exposures><verbal><well-being><wellbeing><young adult><young adult age><young adult with ASD><young adult with autism><young adult with autism spectrum disorder><young adulthood><youngster>

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WEI SUN

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$637,554

FY 2026

Project Title

mHealth Technologies for Assessing Hearing Disorders

Grant Number:

1R01EB038336-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Abstract Sound Sensitivity and Tolerance (SST) disorders represent an urgent public health challenge in hearing disorders, affecting over 350,000 new patients annually in the United States with an economic burden exceeding $14 billion. While SST frequently co-occurs with conditions like auti...

Research Terms

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Wenyao Xu

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$637,554

FY 2026

Project Title

mHealth Technologies for Assessing Hearing Disorders

Grant Number:

1R01EB038336-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Abstract Sound Sensitivity and Tolerance (SST) disorders represent an urgent public health challenge in hearing disorders, affecting over 350,000 new patients annually in the United States with an economic burden exceeding $14 billion. While SST frequently co-occurs with conditions like auti...

Research Terms

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Nicole Renee Tartaglia

UNIVERSITY OF COLORADO DENVER, Aurora, CO

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$629,597

FY 2026

Project Title

The eXtraordinarY Babies Study: Natural History of Health and Neurodevelopment in Infants with Sex Chromosome Trisomy

Grant Number:

5R01HD091251-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/6/2017

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Background: Sex Chromosome Trisomies (SCT) including Klinefelter (XXY), XYY syndrome, and Trisomy X (XXX), occur in 1 out of every 500 births. In childhood there are increased risks for language and learning disabilities, ADHD, autism, and emotional disorders. Medically, SCTs are associated...

Research Terms

<0-11 years old><0-4 weeks old><3 year old><3 years of age><4 year old><4 years of age><47 XYY syndrome><7 year old><7 years of age><8 year old><8 years of age><AD/HD><ADHD><ASD><Aberrant Chromosome><Active Follow-up><Address><Age Months><Age Years><Antenatal Diagnosis><Attention><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Behavior><Biological><Biological Markers><Biological Specimen Banks><Biological Substance Banks><Birth><Birth Defects><Blood><Blood Reticuloendothelial System><Body Composition><Cardiac defect><Caring><Child><Child Youth><Childhood><Children (0-21)><Chromosomal Aberrations><Chromosomal Abnormalities><Chromosomal Alterations><Chromosome Aberrations><Chromosome Alterations><Chromosome Anomalies><Chromosome abnormality><Clinic><Clinical><Clinical genetics><Cognitive><Common Data Element><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Counseling><Coupled><Cytogenetic Aberrations><Cytogenetic Abnormalities><DEXA><DXA><Data><Data Banks><Databanks><Dental><Development><Developmental Delay><Developmental Delay Disorders><Diagnosis><Disease><Disorder><Dual-Energy X-Ray Absorptiometry><Dual-Energy Xray Absorptiometry><Dysfunction><Dyslexia><Early Infantile Autism><Education><Educational aspects><Emotional disorder><Endocrine><Endocrine Gland Secretion><Enrollment><Environment><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Eye><Eyeball><Failure><Family><Fats><Fatty acid glycerol esters><Functional disorder><Funding><Future><Generalized Growth><Genetic><Genetic Counseling><Goals><Gonadal Steroid Hormones><Gonosomes><Growth><Guidelines><Health><History><Hormonal><Hormones><Infant><Infantile Autism><Insulin Resistance><Intervention><Intervention Trial><Interventional trial><Intrauterine Diagnosis><Investigation><Kanner's Syndrome><Klinefelter><Klinefelter syndrome (KS)><Klinefelter's Syndrome><Klinefelter-Reifenstein syndrome><Klinefelter-Reifenstein-Albright syndrome><Language Development><Language Disorders><Language disability><Learning Disabilities><Learning disability><Length><Life><Linear Models><Logistic Regressions><Longitudinal Studies><Longitudinal Surveys><Measures><Medical><Medical Genetics><Methods><Modeling><Morbidity><Motor><Motor Skills><Natural History><Neonatal Screening><Neural Development><Neurodevelopmental Problem><Neuropsychologies><Neuropsychology><Newborn Infant><Newborn Infant Screening><Newborns><Obesity><Outcome><Parents><Participant><Parturition><Pathway interactions><Phase><Phenotype><Physiopathology><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prenatal Diagnosis><Prenatal Genetic Counseling><Probabilistic Models><Probability Models><Prospective Studies><Protocol><Protocols documentation><QOL><Quality of life><Racial Group><Reading Disabilities><Reading disability><Recording of previous events><Research Resources><Resources><Risk><Risk Factors><Sample Size><Sampling><School-Age Population><Seizures><Sex Chromosomes><Sex Hormones><Sex Steroid Hormones><Shapes><Site><Social Development><Socio-economic status><Socioeconomic Status><Specific Child Development Disorders><Speech><Statistical Models><Stress><Supplementation><Syndrome><Testing><Testosterone><Therapeutic Hormone><Therapeutic Testosterone><Tissue Growth><Torticollis><Trans-Testosterone><Triple X syndrome><Trisomy><Trisomy 8 Syndrome><Trisomy X syndrome><Underrepresented Groups><Underrepresented Populations><Urine><Word Blindness><Work><Wryneck><XXX female><XXX syndrome><XXY syndrome><XXY trisomy><XYY Karyotype><XYY male><XYY syndrome><XYY trisomy><Xq Klinefelter syndrome><YY syndrome><acquiring language skills><active followup><adiposity><age 3><age 3 years><age 4><age 4 years><age 7><age 7 years><age 8><age 8 years><antepartum diagnosis><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><bio-markers><biobank><biologic><biologic marker><biological specimen repository><biomarker><biorepository><biosample repository><biospecimen bank><biospecimen repository><cardiometabolic><cardiometabolism><chromosomal defect><chromosome X gain><chromosome XXX syndrome><chromosome XXY syndrome><chromosome defect><clinical care><co-morbid><co-morbidity><cohort><cohort investigation><cohort research><comorbidity><corpulence><data depository><data repository><data set repository><data sharing><dataset repository><demographics><developmental><double male syndrome><early childhood><eight year old><eight years of age><enroll><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><ethnic subgroup><ethnicity group><evidence base><experience><eye tracking><fecal sample><feeding><follow up><follow-up><followed up><followup><four year old><four years of age><genetic consultation><gonadal steroids><heart defect><high risk><histories><improved><infancy><infant outcome><infantile><insulin resistant><insulin tolerance><interest><intra-uterine diagnosis><investigate cohort><kids><language acquisition><language deficit><language learning><literacy><long-term study><longitudinal outcome studies><longitudinal research study><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><mortality><motor ability><neurodevelopment><neuropsychologic><newborn child><newborn children><newborn screening><novel><ontogeny><outcome prediction><ovarian failure><parent><pathophysiology><pathway><patient centered><patient oriented><pediatric><penis><premature><prematurity><prenatal><prenatal screening><prenatal testing><prospective><prospective research study><prospective survey><psychologic><psychological><racial minority group><racial minority individual><racial minority people><racial minority population><racial population><racial subgroup><reading ability><reading achievement><reading competence><reading proficiency><recruit><risk selection><rural area><rural location><rural region><school age><seminiferous tubule dysgenesis><seven year old><seven years of age><sex steroid><skills><socio-economic position><socioeconomic position><specimen bank><specimen repository><standardize measure><statistical linear mixed models><statistical linear models><stool sample><stool specimen><study cohort><survey cohort><three year old><three years of age><triple-X chromosome syndrome><trisomy X><unborn><under representation of groups><under represented groups><under represented people><under represented populations><underrepresentation of groups><underrepresented people><visual tracking><youngster>

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AMY LEE

UNIVERSITY OF TEXAS AT AUSTIN, AUSTIN, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$613,161

FY 2026

Project Title

Functions of caldendrin in sensory neurons

Grant Number:

1R01NS146834-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/7/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Hypersensitivity to touch is common in neurodevelopmental disorders including autism spectrum disorder (ASD). Individuals with ASD can have aversive responses to certain textures or human touch, which can lead to emotional distress, social withdrawal, and difficulties accomplishing e...

Research Terms

<21+ years old><ASD><Adult><Adult Human><Affective><Afferent Neurons><Ammon Horn><Anxiety><Autism><Autistic Disorder><Automobile Driving><Basic Research><Basic Science><Behavior><Behavioral Assay><Binding><Biochemical><Biochemistry><Biological><Biological Chemistry><Biophysics><Brain><Brain Nervous System><CNS Nervous System><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Matrix><Central Nervous System><Clinical><Cognition><Cognitive><Complex><Cornu Ammonis><Coupling><Cues><Cytoplasm><Cytoskeletal System><Cytoskeleton><Data><Development><Dietary Fatty Acid><Differences between sexes><Differs between sexes><Disease><Disorder><Dorsal Root Ganglia><Down-Regulation><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Etiology><Exhibits><Fatty Acids><Female><Functional disorder><Gene Transcription><Generalized Growth><Genes><Genetic><Genetic Transcription><Goals><Growth><Health><Hippocampus><Human><Hypersensitivity><Individual><Infantile Autism><Intervention><Intervention Strategies><Intracellular Communication and Signaling><Ion Channel><Ionic Channels><KO mice><Kanner's Syndrome><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><Learning><Link><MeCP-2 protein><MeCP2><MeCP2 protein><Mechanics><Mediating><Membrane Channels><Memory><Methods><Methyl CpG binding protein MeCP2><Methyl-CpG-Binding Protein 2><Methyl-DNA binding protein MECP2><Mice><Mice Mammals><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neuraxis><Neurites><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Neurophysiology / Electrophysiology><Null Mouse><Organism-Level Process><Organismal Process><Pathway interactions><Pattern><Perinatal><Peripartum><Peripheral><Peripheral Nervous System><Phenotype><Physiologic Processes><Physiological Processes><Physiopathology><Piezo 2><Piezo 2 ion channel><Piezo ion channels><Piezo2><Prevalence><Process><Proprioception><Proteins><RNA Expression><Research><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><Sensory Neurons><Sex Differences><Sexual differences><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Social Behavior><Societies><Spinal Ganglia><Synaptic plasticity><Tactile><Testing><Texture><Tissue Growth><Touch><Touch sensation><Transcription><Transfection><Translational Research><Translational Science><Transmission><Withdrawal><adulthood><antisocial behavior><autism model><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic people><autistic spectrum disorder><biologic><biological sex as a modifier><biological signal transduction><biophysical foundation><biophysical principles><biophysical sciences><caldendrin><causation><defined contribution><developmental><diagnostic approach><diagnostic strategy><disease causation><dorsal root ganglion><driving><electrophysiological><emotional distress><feeling distress><feeling upset><hippocampal><human model><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><innovate><innovation><innovative><intracellular skeleton><later in life><later life><loss of function><machine learned algorithm><machine learning algorithm><machine learning based algorithm><male><mechanic><mechanical><model of autism spectrum disorder><model of human><mouse model><murine model><neonatal mice><neurite growth><neurodevelopment><neurodevelopmental disease><neuronal><new diagnostics><next generation diagnostics><novel diagnostics><ontogeny><optic imaging><optical imaging><pathophysiology><pathway><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><pharmacologic><piezo channels><response><sensory mechanism><sex><sex as a biological factor><sex as a biological measure><sex as a biological risk factor><sex as a biological variable><sex as a biological variance><sex as a biologically significant variable><sex as a fundamental variable><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social><social role><sociobehavior><sociobehavioral><tactile display><tactile sensation><trait><translation research><translational investigation><transmission process><♀><♂>

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JAMES S DUNCAN

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$612,498

FY 2026

Project Title

Dynamic Functional Image-based Deep Learning for Therapy Assessment in Autism

Grant Number:

5R01NS035193-27

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/1996

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Autism spectrum disorder (ASD) is a developmental disorder characterized by impairment of social interaction and communication, as well as repetitive behaviors, with severity ranging from mild to signiﬁcantly disabling. The prevalence in the United States is rising (currently about 1...

Research Terms

<0-11 years old><AD/HD><ADHD><ASD><Accounting><Anxiety><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biological Markers><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain Pathology><Brain imaging><Brain region><Categories><Cell Communication and Signaling><Cell Signaling><Characteristics><Child><Child Behavior Checklist><Child Behavioral Checklist><Child Youth><Childhood Behavior Checklist><Children (0-21)><Children Behavior Checklist><Classification><Clinical><Clinical assessments><Cognition Therapy><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Communities><Conditioning Therapy><ConvNet><DNA Molecular Biology><Data><Data Bases><Data Set><Databases><Dependence><Development><Disabling><Disease><Disorder><Drug Therapy><Dysfunction><Early Infantile Autism><Encephalon><Encephalon Diseases><Functional Imaging><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Genetic><Goals><Graph><Heterogeneity><Image Analyses><Image Analysis><Impairment><Individual><Infantile Autism><Institution><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Judgment><Kanner's Syndrome><Learning><Literature><MR Imaging><MR Tomography><MRI><MRIs><Machine Learning><Magnetic Resonance Imaging><Measurement><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental Depression><Methodological Studies><Methodology><Methods><Modeling><Molecular Biology><NMR Imaging><NMR Tomography><Neurosciences><Nuclear Magnetic Resonance Imaging><Ocytocin><Outcome Measure><Oxytocin><PARP Polymerase><PARP protein><PARS><Patients><Performance><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiologic Imaging><Physiopathology><Poly(ADP-ribose) Polymerases><Poly(ADPribose) Polymerase><Prediction of Response to Therapy><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prevalence><Privacy><Recombinant Oxytocin><Rest><Secure><Services><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Social Interaction><Subcategory><Subgroup><Supportive Therapy><Supportive care><Systematics><Techniques><Technology><Testing><Time><Training><Treatment outcome><United States><Universities><Virginia><Work><Zeugmatography><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><base><bases><behavior intervention><behavioral intervention><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker identification><brain visualization><childhood anxiety><co-morbid><co-morbidity><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cohort><comorbidity><convolutional network><convolutional neural nets><convolutional neural network><cost><data base><data exchange><data transfer><data transmission><deep learning><deep learning method><deep learning strategy><depression><design><designing><developmental><developmental disease><developmental disorder><drug intervention><drug treatment><evidence base><fMRI><federated learning><graph attention network><graph convolutional network><graph neural network><identification of biomarkers><identification of new biomarkers><image evaluation><image interpretation><improved><improved outcome><individualized biomarkers><individualized predictions><innovate><innovation><innovative><kids><large data sets><large datasets><learning activity><learning method><learning network><learning strategies><learning strategy><long short term memory><machine based learning><marker identification><measurable outcome><neuroimaging biomarker><neuroimaging marker><new approaches><novel><novel approaches><novel strategies><novel strategy><outcome measurement><outcome prediction><pathophysiology><pediatric anxiety><personalization of treatment><personalized biomarkers><personalized medicine><personalized predictions><personalized therapy><personalized treatment><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><physiological imaging><poly ADP polymerase><poly ADP ribose synthetase><predict therapeutic response><predict therapy response><privacy preservation><psychiatric co-morbidity><psychiatric comorbidity><psychoeducation><quantitative imaging><recurrent neural network><repetitive behavior><response to therapy><response to treatment><social><social communication><spatial and temporal><spatial relationship><spatial temporal><spatiotemporal><task analysis><therapeutic outcome><therapeutic response><therapy outcome><therapy prediction><therapy response><tool><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><treatment strategy><youngster><youth anxiety>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

LAWRENCE H. STAIB

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$612,498

FY 2026

Project Title

Dynamic Functional Image-based Deep Learning for Therapy Assessment in Autism

Grant Number:

5R01NS035193-27

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/1996

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Autism spectrum disorder (ASD) is a developmental disorder characterized by impairment of social interaction and communication, as well as repetitive behaviors, with severity ranging from mild to signiﬁcantly disabling. The prevalence in the United States is rising (currently about 1...

Research Terms

<0-11 years old><AD/HD><ADHD><ASD><Accounting><Anxiety><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biological Markers><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain Pathology><Brain imaging><Brain region><Categories><Cell Communication and Signaling><Cell Signaling><Characteristics><Child><Child Behavior Checklist><Child Behavioral Checklist><Child Youth><Childhood Behavior Checklist><Children (0-21)><Children Behavior Checklist><Classification><Clinical><Clinical assessments><Cognition Therapy><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Communities><Conditioning Therapy><ConvNet><DNA Molecular Biology><Data><Data Bases><Data Set><Databases><Dependence><Development><Disabling><Disease><Disorder><Drug Therapy><Dysfunction><Early Infantile Autism><Encephalon><Encephalon Diseases><Functional Imaging><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Genetic><Goals><Graph><Heterogeneity><Image Analyses><Image Analysis><Impairment><Individual><Infantile Autism><Institution><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Judgment><Kanner's Syndrome><Learning><Literature><MR Imaging><MR Tomography><MRI><MRIs><Machine Learning><Magnetic Resonance Imaging><Measurement><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental Depression><Methodological Studies><Methodology><Methods><Modeling><Molecular Biology><NMR Imaging><NMR Tomography><Neurosciences><Nuclear Magnetic Resonance Imaging><Ocytocin><Outcome Measure><Oxytocin><PARP Polymerase><PARP protein><PARS><Patients><Performance><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiologic Imaging><Physiopathology><Poly(ADP-ribose) Polymerases><Poly(ADPribose) Polymerase><Prediction of Response to Therapy><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prevalence><Privacy><Recombinant Oxytocin><Rest><Secure><Services><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Social Interaction><Subcategory><Subgroup><Supportive Therapy><Supportive care><Systematics><Techniques><Technology><Testing><Time><Training><Treatment outcome><United States><Universities><Virginia><Work><Zeugmatography><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><base><bases><behavior intervention><behavioral intervention><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker identification><brain visualization><childhood anxiety><co-morbid><co-morbidity><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cohort><comorbidity><convolutional network><convolutional neural nets><convolutional neural network><cost><data base><data exchange><data transfer><data transmission><deep learning><deep learning method><deep learning strategy><depression><design><designing><developmental><developmental disease><developmental disorder><drug intervention><drug treatment><evidence base><fMRI><federated learning><graph attention network><graph convolutional network><graph neural network><identification of biomarkers><identification of new biomarkers><image evaluation><image interpretation><improved><improved outcome><individualized biomarkers><individualized predictions><innovate><innovation><innovative><kids><large data sets><large datasets><learning activity><learning method><learning network><learning strategies><learning strategy><long short term memory><machine based learning><marker identification><measurable outcome><neuroimaging biomarker><neuroimaging marker><new approaches><novel><novel approaches><novel strategies><novel strategy><outcome measurement><outcome prediction><pathophysiology><pediatric anxiety><personalization of treatment><personalized biomarkers><personalized medicine><personalized predictions><personalized therapy><personalized treatment><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><physiological imaging><poly ADP polymerase><poly ADP ribose synthetase><predict therapeutic response><predict therapy response><privacy preservation><psychiatric co-morbidity><psychiatric comorbidity><psychoeducation><quantitative imaging><recurrent neural network><repetitive behavior><response to therapy><response to treatment><social><social communication><spatial and temporal><spatial relationship><spatial temporal><spatiotemporal><task analysis><therapeutic outcome><therapeutic response><therapy outcome><therapy prediction><therapy response><tool><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><treatment strategy><youngster><youth anxiety>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

DENIS G SUKHODOLSKY

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$612,498

FY 2026

Project Title

Dynamic Functional Image-based Deep Learning for Therapy Assessment in Autism

Grant Number:

5R01NS035193-27

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/1996

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Autism spectrum disorder (ASD) is a developmental disorder characterized by impairment of social interaction and communication, as well as repetitive behaviors, with severity ranging from mild to signiﬁcantly disabling. The prevalence in the United States is rising (currently about 1...

Research Terms

<0-11 years old><AD/HD><ADHD><ASD><Accounting><Anxiety><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biological Markers><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain Pathology><Brain imaging><Brain region><Categories><Cell Communication and Signaling><Cell Signaling><Characteristics><Child><Child Behavior Checklist><Child Behavioral Checklist><Child Youth><Childhood Behavior Checklist><Children (0-21)><Children Behavior Checklist><Classification><Clinical><Clinical assessments><Cognition Therapy><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Communities><Conditioning Therapy><ConvNet><DNA Molecular Biology><Data><Data Bases><Data Set><Databases><Dependence><Development><Disabling><Disease><Disorder><Drug Therapy><Dysfunction><Early Infantile Autism><Encephalon><Encephalon Diseases><Functional Imaging><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Genetic><Goals><Graph><Heterogeneity><Image Analyses><Image Analysis><Impairment><Individual><Infantile Autism><Institution><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Judgment><Kanner's Syndrome><Learning><Literature><MR Imaging><MR Tomography><MRI><MRIs><Machine Learning><Magnetic Resonance Imaging><Measurement><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental Depression><Methodological Studies><Methodology><Methods><Modeling><Molecular Biology><NMR Imaging><NMR Tomography><Neurosciences><Nuclear Magnetic Resonance Imaging><Ocytocin><Outcome Measure><Oxytocin><PARP Polymerase><PARP protein><PARS><Patients><Performance><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiologic Imaging><Physiopathology><Poly(ADP-ribose) Polymerases><Poly(ADPribose) Polymerase><Prediction of Response to Therapy><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prevalence><Privacy><Recombinant Oxytocin><Rest><Secure><Services><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Social Interaction><Subcategory><Subgroup><Supportive Therapy><Supportive care><Systematics><Techniques><Technology><Testing><Time><Training><Treatment outcome><United States><Universities><Virginia><Work><Zeugmatography><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><base><bases><behavior intervention><behavioral intervention><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker identification><brain visualization><childhood anxiety><co-morbid><co-morbidity><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cohort><comorbidity><convolutional network><convolutional neural nets><convolutional neural network><cost><data base><data exchange><data transfer><data transmission><deep learning><deep learning method><deep learning strategy><depression><design><designing><developmental><developmental disease><developmental disorder><drug intervention><drug treatment><evidence base><fMRI><federated learning><graph attention network><graph convolutional network><graph neural network><identification of biomarkers><identification of new biomarkers><image evaluation><image interpretation><improved><improved outcome><individualized biomarkers><individualized predictions><innovate><innovation><innovative><kids><large data sets><large datasets><learning activity><learning method><learning network><learning strategies><learning strategy><long short term memory><machine based learning><marker identification><measurable outcome><neuroimaging biomarker><neuroimaging marker><new approaches><novel><novel approaches><novel strategies><novel strategy><outcome measurement><outcome prediction><pathophysiology><pediatric anxiety><personalization of treatment><personalized biomarkers><personalized medicine><personalized predictions><personalized therapy><personalized treatment><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><physiological imaging><poly ADP polymerase><poly ADP ribose synthetase><predict therapeutic response><predict therapy response><privacy preservation><psychiatric co-morbidity><psychiatric comorbidity><psychoeducation><quantitative imaging><recurrent neural network><repetitive behavior><response to therapy><response to treatment><social><social communication><spatial and temporal><spatial relationship><spatial temporal><spatiotemporal><task analysis><therapeutic outcome><therapeutic response><therapy outcome><therapy prediction><therapy response><tool><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><treatment strategy><youngster><youth anxiety>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Pamela Ventola

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$612,498

FY 2026

Project Title

Dynamic Functional Image-based Deep Learning for Therapy Assessment in Autism

Grant Number:

5R01NS035193-27

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/1996

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Autism spectrum disorder (ASD) is a developmental disorder characterized by impairment of social interaction and communication, as well as repetitive behaviors, with severity ranging from mild to signiﬁcantly disabling. The prevalence in the United States is rising (currently about 1...

Research Terms

<0-11 years old><AD/HD><ADHD><ASD><Accounting><Anxiety><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biological Markers><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain Pathology><Brain imaging><Brain region><Categories><Cell Communication and Signaling><Cell Signaling><Characteristics><Child><Child Behavior Checklist><Child Behavioral Checklist><Child Youth><Childhood Behavior Checklist><Children (0-21)><Children Behavior Checklist><Classification><Clinical><Clinical assessments><Cognition Therapy><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Communities><Conditioning Therapy><ConvNet><DNA Molecular Biology><Data><Data Bases><Data Set><Databases><Dependence><Development><Disabling><Disease><Disorder><Drug Therapy><Dysfunction><Early Infantile Autism><Encephalon><Encephalon Diseases><Functional Imaging><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Genetic><Goals><Graph><Heterogeneity><Image Analyses><Image Analysis><Impairment><Individual><Infantile Autism><Institution><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Judgment><Kanner's Syndrome><Learning><Literature><MR Imaging><MR Tomography><MRI><MRIs><Machine Learning><Magnetic Resonance Imaging><Measurement><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental Depression><Methodological Studies><Methodology><Methods><Modeling><Molecular Biology><NMR Imaging><NMR Tomography><Neurosciences><Nuclear Magnetic Resonance Imaging><Ocytocin><Outcome Measure><Oxytocin><PARP Polymerase><PARP protein><PARS><Patients><Performance><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiologic Imaging><Physiopathology><Poly(ADP-ribose) Polymerases><Poly(ADPribose) Polymerase><Prediction of Response to Therapy><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prevalence><Privacy><Recombinant Oxytocin><Rest><Secure><Services><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Social Interaction><Subcategory><Subgroup><Supportive Therapy><Supportive care><Systematics><Techniques><Technology><Testing><Time><Training><Treatment outcome><United States><Universities><Virginia><Work><Zeugmatography><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><base><bases><behavior intervention><behavioral intervention><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker identification><brain visualization><childhood anxiety><co-morbid><co-morbidity><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cohort><comorbidity><convolutional network><convolutional neural nets><convolutional neural network><cost><data base><data exchange><data transfer><data transmission><deep learning><deep learning method><deep learning strategy><depression><design><designing><developmental><developmental disease><developmental disorder><drug intervention><drug treatment><evidence base><fMRI><federated learning><graph attention network><graph convolutional network><graph neural network><identification of biomarkers><identification of new biomarkers><image evaluation><image interpretation><improved><improved outcome><individualized biomarkers><individualized predictions><innovate><innovation><innovative><kids><large data sets><large datasets><learning activity><learning method><learning network><learning strategies><learning strategy><long short term memory><machine based learning><marker identification><measurable outcome><neuroimaging biomarker><neuroimaging marker><new approaches><novel><novel approaches><novel strategies><novel strategy><outcome measurement><outcome prediction><pathophysiology><pediatric anxiety><personalization of treatment><personalized biomarkers><personalized medicine><personalized predictions><personalized therapy><personalized treatment><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><physiological imaging><poly ADP polymerase><poly ADP ribose synthetase><predict therapeutic response><predict therapy response><privacy preservation><psychiatric co-morbidity><psychiatric comorbidity><psychoeducation><quantitative imaging><recurrent neural network><repetitive behavior><response to therapy><response to treatment><social><social communication><spatial and temporal><spatial relationship><spatial temporal><spatiotemporal><task analysis><therapeutic outcome><therapeutic response><therapy outcome><therapy prediction><therapy response><tool><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><treatment strategy><youngster><youth anxiety>

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Xiaochang Zhang

UNIVERSITY OF CHICAGO, CHICAGO, IL

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$609,214

FY 2026

Project Title

Rescuing SYNGAP1 haploinsufficiency by redirecting alternative splicing

Grant Number:

5R01MH130594-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Synaptic transmission and plasticity are fundamental to neuronal functions, and dysregulations of synaptic protein expression are direct causes of neurodevelopmental disorders such as autism. Over one hundred de novo loss-of-function mutations in SYNGAP1 have been unambiguously assoc...

Research Terms

<3' Splice Site><AMPA Receptors><ASD><Ablation><Alleles><Allelic Loss><Allelomorphs><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Ammon Horn><Animals><Autism><Autistic Disorder><Behavior><Behavioral><Brain><Brain Nervous System><Cell Body><Cells><Cornu Ammonis><Coupled><Defect><Development><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Elements><Encephalon><Event><Exons><GEM model><GEMM model><Genetic><Genetically Engineered Mouse><Glutamates><Heterozygote><Hippocampus><Human><Human Development><Impairment><Induced pluripotent stem cell derived human neuron><Induced pluripotent stem cell derived neurons><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Isoforms><KO mice><Kanner's Syndrome><Knock-out><Knock-out Mice><Knockout><Knockout Mice><L-Glutamate><Lead><Long-Term Potentiation><Loss of Heterozygosity><Mediating><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Mutant Strains Mice><Neocortex><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neural Transmission><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neurons><Neurophysiology / Electrophysiology><Null Mouse><Oligo><Oligonucleotides><Patients><Pb element><Phenotype><Physiologic><Physiological><Pilot Projects><Protein Isoforms><Proteins><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Splicing><Reagent><Reporting><Research Grants><Research Project Grants><Research Projects><SYNGAP1><Spinal Column><Spine><Splice Acceptor Sites><Splicing><Synapses><Synaptic><Synaptic Ras GTPase Activating Protein 1><Synaptic Transmission><Synaptic plasticity><Testing><Toxic effect><Toxicities><Vertebral column><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><backbone><determine efficacy><developmental><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electrophysiological><evaluate efficacy><examine efficacy><genetic approach><genetic strategy><genetically engineered mouse model><genetically engineered murine model><glutamatergic><heavy metal Pb><heavy metal lead><heterozygosity><hiPSC-derived neurons><hippocampal><homotypical cortex><human iPSC-derived sensory neuron><human induced pluripotent stem cell derived sensory neuron><iPS neurons><iPSC derived-neurons><iPSC-derived human neuron><induced pluripotent stem cell neurons><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><inducible pluripotent stem cell derived human neuron><inducible pluripotent stem cell derived human sensory neuron><insight><intellectual and developmental disability><isocortex><learned behavior><learning behavior><limited intellectual functioning><loss of function><loss of function mutation><mRNA Decay><mouse development><mouse genetics><mouse model><mouse mutant><murine model><neopallium><neurodevelopment><neurodevelopmental disease><neuronal><neurons derived from induced pluripotent stem cells><neurons differentiated from human induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><oligos><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient-derived pluripotent stem cells><pilot study><postnatal><pre-clinical><preclinical><protein expression><success><synapse><therapeutic target>

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Marco Matthias Hefti

UNIVERSITY OF IOWA, IOWA CITY, IA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$555,197

FY 2026

Project Title

A non-canonical role for tau in early human brain development

Grant Number:

5R01NS136448-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Although best known for its role in Alzheimer disease, the tau protein is a significant driver of neuronal network dysfunction in neurodevelopmental disorders, including epilepsy and autism, which have a devastating lifelong impact on function and quality of life. Tau phosphorylation, detachment fro...

Research Terms

<21+ years old><AD dementia><ASD><Acquired brain injury><Adult><Adult Human><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Autism><Autistic Disorder><Axon><Binding><Biologic Models><Biological Models><Brain><Brain Injuries><Brain Nervous System><Cell Line><CellLine><Data><Dendrites><Development><Disease><Disorder><Drugs><Early Infantile Autism><Encephalon><Ensure><Epilepsy><Epileptic Seizures><Epileptics><FYN Protein><Goals><Human><Impairment><In Vitro><Infantile Autism><KI mice><Kanner's Syndrome><Kinases><Knock-in Mouse><Knock-out><Knockout><Knowledge><Life><Literature><MT-bound tau><Medication><Mice><Mice Mammals><Micro-tubule><Microtubules><Model System><Modern Man><Molecular Interaction><Murine><Mus><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><NMDA Receptor-Ionophore Complex><NMDA Receptors><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Outcome><Pathology><Pathway interactions><Pharmaceutical Preparations><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiological><Primary Senile Degenerative Dementia><Process><Protein Phosphorylation><Proto-Oncogene Proteins c-fyn><Publishing><QOL><Quality of life><Receptor Signaling><Reducing Agents><Reductants><Rodent><Rodentia><Rodents Mammals><Role><Safety><Seizure Disorder><Strains Cell Lines><Stress><Structure><Synapses><Synaptic><Testing><Therapeutic><Toxic effect><Toxicities><Translating><Transphosphorylases><Upregulation><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><brain damage><brain-injured><c-fyn protein><cultured cell line><developmental><drug/agent><epilepsia><epileptogenic><experiment><experimental research><experimental study><experiments><fetal><fyn tyrosine kinase><gain of function><human fetal brain><human model><human progenitor><human progenitor cell derived><human stem cell-derived><human stem cells><hypoxic ischemic injury><knockin mice><microtubule bound tau><microtubule-bound tau><model of human><network dysfunction><neurodevelopment><neurodevelopmental disease><neuron toxicity><neuronal><neuronal toxicity><neurotoxicity><p-tau><p-τ><pathway><phospho-tau><phospho-τ><phosphorylated tau><post-translational modification of tau><postnatal><posttranslational modification of tau><primary degenerative dementia><protein function><proto-oncogene protein c-syn><senile dementia of the Alzheimer type><social role><synapse><targeted agent><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tau><tau Proteins><tau factor><tau function><tau phosphorylation><tau posttranslational modification><tau-1><therapeutic target><τ Proteins><τ function><τ phosphorylation>

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JEANNE Bentley LAWRENCE

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$535,709

FY 2026

Project Title

A Novel Approach to Molecular Cell Pathologies of Human Down Syndrome and DS-AD

Grant Number:

4R01HD091357-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/12/2017

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Down Syndrome (DS), or Trisomy 21 (T21), is a highly common cause of cognitive disability in children, and also impacts individuals throughout life, by increased risks of congenital heart disease, viral susceptibility, leukemia, and conditions such as metabolic, autoimmune and autism spectr...

Research Terms

<0-11 years old><21+ years old><AD dementia><AD model><ADAM10 protein><ASD><Aberrant Chromosome><Address><Adult><Adult Human><Affect><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimers Dementia><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Autism><Autistic Disorder><Autoimmune><Aβ><Body Tissues><Brain><Brain Nervous System><Cardiac Malformation><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Child><Child Youth><Children (0-21)><Chromosomal Aberrations><Chromosomal Abnormalities><Chromosomal Alterations><Chromosomal Amplification><Chromosomal Duplication><Chromosome 21><Chromosome Aberrations><Chromosome Alterations><Chromosome Anomalies><Chromosome abnormality><Chromosomes><Cilia><Cognitive deficits><Cytogenetic Aberrations><Cytogenetic Abnormalities><Development><Disease><Disorder><Down Syndrome><Drug Targeting><EOAD><Early Infantile Autism><Early Onset Alzheimer Disease><Encephalon><Endothelial Cells><Equilibrium><Functional RNA><Funding><Gene Cluster><Gene Expression><Genes><Genetic><Genome><Heart Malformation><Hematopoietic><Human><Human Pathology><In Vitro><Individual><Individuals with down syndrome><Infantile Autism><Intracellular Communication and Signaling><Kanner's Syndrome><Knowledge><Langdon Down syndrome><Life><Medical><Metabolic><Methods><Modeling><Modern Man><Molecular><Mongolism><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuron Degeneration><Neurons><Non-Polyadenylated RNA><Noncoding RNA><Nontranslated RNA><Organoids><Pathogenesis><Pathology><Pathway interactions><Persons><Phenotype><Population><Post-Transcriptional Gene Silencing><Predisposition><Premature Aging><Premature aging syndrome><Primary Senile Degenerative Dementia><Progenitor Cells><RNA><RNA Gene Products><RNA Interference><RNA Seq><RNA Silencing><RNA sequencing><RNAi><RNAseq><Repression><Research Resources><Resources><Ribonucleic Acid><Risk><Role><Sequence-Specific Posttranscriptional Gene Silencing><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Susceptibility><System><Testing><Therapeutic><Tissues><Trisomy><Trisomy 21><Untranslated RNA><Variant><Variation><Vascular System><Viral><Viral Diseases><Virus Diseases><Work><a beta peptide><abeta><abnormal heart development><adulthood><alzheimer model><amyloid beta><amyloid-b protein><angiogenesis><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><balance><balance function><beta amyloid fibril><biological signal transduction><cell type><cellular differentiation><chromosomal defect><chromosome 21 trisomy><chromosome 21 trisomy syndrome><chromosome defect><cognitive defects><cognitive disability><cognitively disabled><congenital acromicria syndrome><congenital cardiac abnormality><congenital cardiac anomalies><congenital cardiac disease><congenital cardiac disorder><congenital cardiac malformation><congenital heart abnormality><congenital heart anomaly><congenital heart disease><congenital heart disorder><congenital heart malformation><developmental><dosage><down syndrome individuals><down syndrome patients><drug development><early onset AD><early onset Alzheimer's><expectation><gamma secretase><gamma secretase complex><genome scale><genome-wide><genomewide><hemopoietic><iPS><iPSC><iPSCs><improved><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><kids><leukemia><morbus Down><neural degeneration><neurodegeneration><neurodegenerative><neurogenesis><neurological degeneration><neuronal><neuronal degeneration><new approaches><noncoding><novel><novel approaches><novel strategies><novel strategy><overexpress><overexpression><pathway><patients with down syndrome><people with down syndrome><primary degenerative dementia><pseudohypertrophic progressive muscular dystrophy><response><scRNA sequencing><scRNA-seq><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><soluble amyloid precursor protein><stem cells><tool><transcriptome sequencing><transcriptomic sequencing><transcriptomics><trisomy 21 syndrome><viral infection><virus infection><virus-induced disease><youngster><γ-secretase>

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Iuliana Ionita

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$534,191

FY 2026

Project Title

Genetic discovery for neuropsychiatric traits in deep phenotype data: novel methods and applications

Grant Number:

1R01MH140223-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary One of the major problems in human genetics is understanding the genetic causes underlying complex phenotypes, including neuropsychiatric traits such as autism spectrum disorders, bipolar and schizophrenia. Despite tremendous work over the past few decades, it has been frustratingly difficul...

Research Terms

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Jeremy E Rosenkranz

ROSALIND FRANKLIN UNIV OF MEDICINE & SCI, NORTH CHICAGO, IL

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$528,357

FY 2026

Project Title

Role of neurexin in social adaptation and amygdala plasticity

Grant Number:

5R01MH137651-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/5/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project summary Social relationships benefit mental and physical health, while poor quality social interactions are associated with worse health and higher mortality. The abilities that underlie social function are impaired in Autism Spectrum Disorder (ASD). There has been substantial progress in id...

Research Terms

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CHARLES Alexander NELSON

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Large award

Active award

$1,265,443

FY 2026

Project Title

Predicting ASD and Other Developmental Outcomes in the First Year of Life Using EEG in a Diverse Community-Based Sample

Grant Number:

5R01NS120986-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2021

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary Children with autism who receive early intervention services have better outcomes than those who do not. It is therefore imperative to lower the age of diagnosis. There is strong evidence that there are reliable behavioral signs/symptoms of the disorder that emerge in the second year...

Research Terms

<0-11 years old><2 year old><2 years of age><ASD><African American><Afro American><Afroamerican><Age><Autism><Autism Diagnosis><Autistic Disorder><Behavioral><Biologic Factor><Biological Factors><Biological Markers><Black><Black race><Boston><Brain><Brain Nervous System><CNS plasticity><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Clinic><Clinical><Cognitive><Communities><Complex><Data><Data Collection><Decrease disparity><Development><Developmental Delay><Developmental Delay Disorders><Diagnosis><Diagnosis disparity><Diagnostic><Diagnostic Findings><Diagnostic disparity><Disease><Disorder><Disparities><Disparity><Disparity in diagnosis><EEG><Early Infantile Autism><Early Intervention><Early identification><Electroencephalogram><Electroencephalography><Encephalon><Enrollment><Environmental Factor><Environmental Risk Factor><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Frequencies><General Population><General Public><Genetic><Goals><Health Care Facility><Health Facilities><High Prevalence><Hispanic><Hispanic Americans><History><Home><Household><Individual><Infant><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Judgment><Kanner's Syndrome><Laboratories><Language><Life><Low income><Lower disparity><Maternal Health><Measures><Medical Records><Modeling><Neurobiology><Neuronal Plasticity><Outcome><Parental Ages><Pattern><Pediatric Hospitals><Population><Population Heterogeneity><Predictive Value><Prevalence><Primary Care><Prospective Studies><Publishing><Questionnaires><Race><Races><Racial Group><Recording of previous events><Reporting><Research><Research Design><Research Resources><Resources><Rest><Risk><Risk Factors><Sampling><Severities><Signs and Symptoms><Source><Specific Child Development Disorders><Specificity><Stress><Study Type><Underrepresented Groups><Underrepresented Populations><Well baby checks><Well baby checkups><Well baby visits><Work><age 2><age 2 years><aged 2 years><aged two years><ages><autism attributes><autism biomarker><autism indicator><autism marker><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic children><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><bio-markers><biologic marker><biomarker><biomarker development><care facilities><central nervous system plasticity><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical applicability><clinical application><co-morbid><co-morbidity><comorbidity><computer based prediction><data-driven model><developmental><developmental disease><developmental disorder><disparity reduction><diverse populations><early life stress><enroll><environmental risk><ethnic diversity><ethnic minority><ethnic subgroup><ethnically diverse><ethnicity group><functional outcomes><global developmental delay><heterogeneous population><high dimensionality><histories><homes><improved><improved outcome><indexing><infant well check><infant well visits><intellectual and developmental disability><kids><limited intellectual functioning><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><machine learning based method><machine learning method><machine learning methodologies><maternal stress><mitigate disparity><neural><neural mechanism><neural plasticity><neurobiological><neuromechanism><neuroplastic><neuroplasticity><non-genetic><nongenetic><pediatric><population diversity><predictive modeling><prenatal><primary care clinic><primary care setting><prospective research study><prospective survey><racial><racial background><racial diversity><racial minority><racial origin><racial population><racial subgroup><racially diverse><reduce disparity><reduction in disparity><retention rate><retention strategy><screening><screenings><service intervention><sex><signal processing><socio-economic><socio-economically><socioeconomically><socioeconomics><stressed mothers><study design><tool><two year old><two years of age><unborn><under representation of groups><under represented groups><under represented people><under represented populations><underrepresentation of groups><underrepresented people><usability><youngster>

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Helen Tager-Flusberg

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Large award

Active award

$1,265,443

FY 2026

Project Title

Predicting ASD and Other Developmental Outcomes in the First Year of Life Using EEG in a Diverse Community-Based Sample

Grant Number:

5R01NS120986-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2021

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary Children with autism who receive early intervention services have better outcomes than those who do not. It is therefore imperative to lower the age of diagnosis. There is strong evidence that there are reliable behavioral signs/symptoms of the disorder that emerge in the second year...

Research Terms

<0-11 years old><2 year old><2 years of age><ASD><African American><Afro American><Afroamerican><Age><Autism><Autism Diagnosis><Autistic Disorder><Behavioral><Biologic Factor><Biological Factors><Biological Markers><Black><Black race><Boston><Brain><Brain Nervous System><CNS plasticity><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Clinic><Clinical><Cognitive><Communities><Complex><Data><Data Collection><Decrease disparity><Development><Developmental Delay><Developmental Delay Disorders><Diagnosis><Diagnosis disparity><Diagnostic><Diagnostic Findings><Diagnostic disparity><Disease><Disorder><Disparities><Disparity><Disparity in diagnosis><EEG><Early Infantile Autism><Early Intervention><Early identification><Electroencephalogram><Electroencephalography><Encephalon><Enrollment><Environmental Factor><Environmental Risk Factor><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Frequencies><General Population><General Public><Genetic><Goals><Health Care Facility><Health Facilities><High Prevalence><Hispanic><Hispanic Americans><History><Home><Household><Individual><Infant><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Judgment><Kanner's Syndrome><Laboratories><Language><Life><Low income><Lower disparity><Maternal Health><Measures><Medical Records><Modeling><Neurobiology><Neuronal Plasticity><Outcome><Parental Ages><Pattern><Pediatric Hospitals><Population><Population Heterogeneity><Predictive Value><Prevalence><Primary Care><Prospective Studies><Publishing><Questionnaires><Race><Races><Racial Group><Recording of previous events><Reporting><Research><Research Design><Research Resources><Resources><Rest><Risk><Risk Factors><Sampling><Severities><Signs and Symptoms><Source><Specific Child Development Disorders><Specificity><Stress><Study Type><Underrepresented Groups><Underrepresented Populations><Well baby checks><Well baby checkups><Well baby visits><Work><age 2><age 2 years><aged 2 years><aged two years><ages><autism attributes><autism biomarker><autism indicator><autism marker><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic children><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><bio-markers><biologic marker><biomarker><biomarker development><care facilities><central nervous system plasticity><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical applicability><clinical application><co-morbid><co-morbidity><comorbidity><computer based prediction><data-driven model><developmental><developmental disease><developmental disorder><disparity reduction><diverse populations><early life stress><enroll><environmental risk><ethnic diversity><ethnic minority><ethnic subgroup><ethnically diverse><ethnicity group><functional outcomes><global developmental delay><heterogeneous population><high dimensionality><histories><homes><improved><improved outcome><indexing><infant well check><infant well visits><intellectual and developmental disability><kids><limited intellectual functioning><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><machine learning based method><machine learning method><machine learning methodologies><maternal stress><mitigate disparity><neural><neural mechanism><neural plasticity><neurobiological><neuromechanism><neuroplastic><neuroplasticity><non-genetic><nongenetic><pediatric><population diversity><predictive modeling><prenatal><primary care clinic><primary care setting><prospective research study><prospective survey><racial><racial background><racial diversity><racial minority><racial origin><racial population><racial subgroup><racially diverse><reduce disparity><reduction in disparity><retention rate><retention strategy><screening><screenings><service intervention><sex><signal processing><socio-economic><socio-economically><socioeconomically><socioeconomics><stressed mothers><study design><tool><two year old><two years of age><unborn><under representation of groups><under represented groups><under represented people><under represented populations><underrepresentation of groups><underrepresented people><usability><youngster>

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GRAEME W DAVIS

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Large award

Active award

$1,179,422

FY 2026

Project Title

Homeostatic Stabilization of Neural Function in Health and Disease

Grant Number:

5R35NS137247-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2032

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Homeostatic plasticity (HP) encompasses a suite of compensatory physiological processes that stabilize neural function. It is widely hypothesized that homeostatic plasticity will be linked to the cause and/or severity of neurodevelopmental disorders including autism and intellectual disabil...

Research Terms

<21+ years old><ASD><Adult><Adult Human><Ammon Horn><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Autism><Autistic Disorder><Brain><Brain Nervous System><Chemosensitization><Chemosensitization/Potentiation><Cornu Ammonis><Disease><Disorder><Drosophila><Drosophila genus><Dysfunction><Early Infantile Autism><Encephalon><Failure><Functional disorder><Gehrig's Disease><Genetic><Genetic Screening><Goals><Health><Hippocampus><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Kanner's Syndrome><Link><Lou Gehrig Disease><Mice><Mice Mammals><Molecular><Murine><Mus><Myoneural Junction><Nervous System Diseases><Nervous System Disorder><Neurodevelopmental Disorder><Neurologic><Neurologic Disorders><Neurological><Neurological Development Disorder><Neurological Disorders><Neuromuscular Diseases><Neuromuscular Junction><Neurophysiology - biologic function><Organism-Level Process><Organismal Process><Peripheral><Physiologic Processes><Physiological Processes><Physiopathology><Potentiation><Preparation><Severities><System><Testing><Translating><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><combat><fruit fly><genome scale><genome-wide><genomewide><hippocampal><intellectual and developmental disability><life span><lifespan><limited intellectual functioning><mouse model><murine model><myoneural disorder><neural function><neurodevelopmental disease><neurological disease><neuromuscular><neuromuscular degenerative disorder><neuromuscular disorder><neuroprotection><neuroprotective><pathophysiology><preparations><presynaptic><resilience><resilient><therapeutic agent development><therapeutic development>

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ARNOLD KRIEGSTEIN

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Large award

Active award

$1,064,849

FY 2026

Project Title

Developmental Topology of the Human Cerebral Cortex

Grant Number:

5R35NS137344-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/18/2024

End Date:

11/30/2032

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary/Abstract A major long-term goal of this proposal is to understand human brain development and the origins of neurodevelopmental diseases. The cerebral cortex is a structure where model systems, such as mouse or rat, may not capture the complexity of architecture and function relevant...

Research Terms

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Megumi J Okumura

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$863,276

FY 2026

Project Title

Resilience in Action™ : Assessing the behavioral target mechanisms of the RiA™ curriculum in young adults with autism

Grant Number:

1R01MH137248-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/3/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract As young adults with autism spectrum disorder (YAASD) transition out of the academic supports provided by school, they can experience a degradation of social skills over time. This increases their risk of poor social, academic, vocational, and health outcomes. YAASD require...

Research Terms

<0-11 years old><12-20 years old><19 year old><19 years of age><20 year old><20 years of age><21+ years old><Academic support><Accounting><Active Follow-up><Address><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Advocacy><Age Years><Anxiety><Area><Assess implementation><Autistic young adult><Baltimore><Behavior assessment><Boston><Care Givers><Caregivers><Child><Child Youth><Childhood><Children (0-21)><Clinical Trials><Communities><Community Trial><Curriculum><Development><Education><Educational Assessment><Educational Curriculum><Educational aspects><Educational process of instructing><Emotional><Emotional well being><Face><Family><Feels well><Fostering><Future><Goals><Health><Impairment><Implementation assessment><Independent Living><Individual><Informal Social Control><Intervention><Intervention Strategies><Life><Maryland><Massachusetts><Measures><Mediating><Mediator><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Multi-center trial><Multicenter Trials><Normal mental condition><Normal mental state><Normal psyche><Outcome><Parents><Participant><Patient Self-Report><Personal awareness><Position><Positioning Attribute><Problem Solving><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychological Well Being><QOL><Quality of life><RE-AIM><Randomized><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Reporting><Risk><Risk Reduction><San Francisco><Schools><Science><Secondary Schools><Self Determination><Self Direction><Self Efficacy><Self Perception><Self Regulation><Self image><Self view><Self-Report><Sense of well-being><Services><Site><Social isolation><Social outcome><System><Teaching><Testing><Time><Training><Vocation><Waiting Lists><Well in self><Youth><Youth 10-21><acceptability and feasibility><active followup><adolescence (12-20)><adulthood><age 19><age 19 years><age 20><age 20 years><aspirate><assess effectiveness><barriers to implementation><behavioral assessment><build resilience><build resiliency><career><community based organizations><community organizations><community setting><compare to control><comparison control><control trial><cost><design><designing><determine effectiveness><develop resilience><develop resiliency><developmental><early childhood><education planning><effectiveness assessment><effectiveness evaluation><effectiveness testing><emotion regulation><emotional regulation><emotional wellbeing><emotional wellness><enhance resilience><enhance resiliency><evaluate effectiveness><evaluate implementation><evaluation of implementation><examine effectiveness><experience><faces><facial><facilitate resilience><feasibility testing><follow up><follow-up><followed up><followup><food preparation><health care management><health management><holistic approach><implementation barriers><implementation challenges><implementation evaluation><implementation intervention><improve resilience><improve resiliency><improved><increase resilience><increase resiliency><innovate><innovation><innovative><instructor><interpersonal competence><interpersonal competency><juvenile><juvenile human><kids><lesson plans><mental illness><mental well-being><mental wellbeing><mental wellness><nineteen year old><nineteen years old><novel><parent><pediatric><peer><pilot test><pilot trial><programs><promote resilience><promote resiliency><protective factors><psychiatric illness><psychological disorder><psychological wellbeing><psychological wellness><randomisation><randomization><randomly assigned><reach, efficacy, adoption, implementation, and maintenance><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><research study><resilience><resilience development><resilient><risk-reducing><satisfaction><secondary education><self awareness><self knowledge><self wellness><sense of wellbeing><skill acquisition><skill development><skills><social><social competence><social competency><social engagement><social involvement><social participation><social skills><stress buffering><stress management><twenty year old><twenty years of age><waitlist><young adult with ASD><young adult with autism><young adult with autism spectrum disorder><youngster><youth age>

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Rachel Reetzke

HUGO W. MOSER RES INST KENNEDY KRIEGER, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$818,502

FY 2026

Project Title

GLOW: Gleaning Language trajectories and Outcomes in autistic toddlers using Wearable brain imaging

Grant Number:

1R01DC023330-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/3/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY During toddlerhood (18–36 months), children seamlessly progress from communicating with single words to using increasingly complex sentences, yet many autistic toddlers remain minimally verbal even after receiving years of early intervention services. Consequently, there is an urgent...

Research Terms

<0-11 years old><18 year old><18 years of age><ASD><Address><Age><Artifacts><Assay><Autism><Autistic Disorder><Behavior><Bilateral><Bioassay><Biological Assay><Brain><Brain Nervous System><Brain imaging><Brain region><Child><Child Youth><Children (0-21)><Clinical><Code><Coding System><Communication><Communities><Complex><Development><Diffuse><Early Infantile Autism><Early Intervention><Encephalon><Exhibits><Friends><Functional MRI><Functional Magnetic Resonance Imaging><Future><Glean><Goals><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Infantile Autism><Intervention><Investigators><Kanner's Syndrome><Language><Language Delays><Language Development><Left><Life><Maps><Measures><Mediating><Mediation><Methods><Modality><Modeling><Morphologic artifacts><Motion><Movement><NIDCD><National Institute on Deafness and Other Communication Disorders><Negotiating><Negotiation><Neurobiology><Nursery Schools><Outcome><Parent-Child Relations><Parent-Child Relationship><Parents><Pattern><Process><Protocol><Protocols documentation><Reporting><Research><Research Personnel><Researchers><Resolution><Sampling><Shapes><Sleep><Social outcome><Standardization><Strategic Planning><Temporal Lobe><Testing><Time><Toddler><Work><acquiring language skills><age 18><age 18 years><ages><autism spectral disorder><autism spectrum disorder><autistic><autistic children><autistic spectrum disorder><awake><body movement><brain behavior><brain visualization><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><computer based prediction><density><developmental><diffuse optical tomography><eighteen year old><eighteen years of age><experience><fMRI><imaging><imaging study><improved><innovate><innovation><innovative><kids><language ability><language acquisition><language learning><language outcome><language processing><language skills><light weight><lightweight><minimally speaking><minimally verbal><movie><natural language><neural><neural correlate><neural imaging><neural mechanism><neural network><neuro-imaging><neurobiological><neuroimaging><neurological imaging><neuromechanism><parent><parent child interaction><parent offspring interaction><peer><personalized health intervention><personalized intervention><pre-k><pre-kindergarten><precision interventions><predictive modeling><preschool><recruit><resolutions><service intervention><sex><temporal cortex><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><youngster>

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Gabrielle Pouchelon

COLD SPRING HARBOR LABORATORY, COLD SPRING HARBOR, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$803,956

FY 2026

Project Title

Postnatal transient connectivity in brain development and implications in fragile x syndrome

Grant Number:

5R01MH136990-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Fragile X syndrome (FXS) is the most common genetic cause of autism spectrum disorders. Autism symptoms in FXS patients typically manifest during early infancy when children actively interact with their environment and form sensory-cognitive associations. During this stage, the neocortex u...

Research Terms

<0-11 years old><21+ years old><3 year old><3 years of age><ASD><Acetylcholine><Address><Adult><Adult Human><Age Months><Anatomic Sites><Anatomic structures><Anatomy><Autism><Autistic Disorder><Automobile Driving><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Birth><Brain><Brain Nervous System><CRISPR><CRISPR/Cas system><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Child><Child Youth><Children (0-21)><Clustered Regularly Interspaced Short Palindromic Repeats><Cognition><Cognitive><Conditioning Therapy><Connector Neuron><Cues><Cyclic Somatostatin><D Cells><Data><Delta Cell><Development><Diagnosis><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Environment><Equilibrium><Escalante syndrome><Foundations><Fragile X><Fragile X Syndrome><Functional disorder><Future><Gene Action Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Genes><Genetic><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Hypersensitivity><Impairment><Infant><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><Kanner's Syndrome><Knowledge><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Measures><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Muscarinic Acetylcholine Receptor><Muscarinic Receptors><Neocortex><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuropeptides><Neurophysiology / Electrophysiology><Parturition><Pathway interactions><Patients><Phenotype><Physiologic><Physiological><Physiopathology><Receptor Protein><Renpenning syndrome 2><Research><Role><SRIH><SRIH-14><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Somatostatin><Somatostatin Cells><Somatostatin Secreting Cell><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><Synapses><Synaptic><Testing><Time><Viral><Work><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><adulthood><age 3><age 3 years><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-fragile X (AFRAX) syndrome><autism-like symptoms><autism-related attributes><autistic children><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><balance><balance function><behavior intervention><behavioral intervention><biological signal transduction><cell type><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cholinergic><combinatorial><critical period><developmental><driving><early onset disorder><effective therapy><effective treatment><electrophysiological><experience><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><genetic approach><genetic strategy><growth hormone release inhibiting factor><homotypical cortex><infancy><infantile><inhibitory neuron><insight><interdisciplinary approach><isocortex><kids><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><molecular biomarker><molecular marker><mouse genetics><mouse model><multidisciplinary approach><murine model><neopallium><neural control><neural regulation><neuromodulation><neuromodulatory><neuronal><neuronal circuit><neuronal circuitry><neuroregulation><novel><pathophysiology><pathway><pharmacologic><postnatal><receptor><social role><synapse><synapse formation><synaptic pruning><synaptogenesis><synergism><therapeutic agent development><therapeutic development><three year old><three years of age><tool><transcriptomics><virtual><youngster>

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Matthias Stadtfeld

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$800,667

FY 2026

Project Title

Transcriptional control by autism associated H3K9 methylation regulators during human neurogenesis

Grant Number:

1R01MH139528-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Mutations that reduce or alter the activity of repressive chromatin modifiers are frequent causes of neurodevelopmental disorders. The inaccessibility of the developing and the dynamic nature of neurogenesis so far have prevented an adequate understanding of how molecular pathologies...

Research Terms

<3-D><3-Dimensional><3D><ASD><Acute><Affect><Alleles><Allelomorphs><Autism><Autistic Disorder><Binding><Brain><Brain Nervous System><Cell Body><Cells><Chromatin><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Chromosomal, Gene, or Protein Abnormality><Clinical><Cytogenetic or Molecular Genetic Abnormality><DNA mutation><Data><Development><Developmental Process><Disease><Disorder><EC 2.1.1><ESET><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Enhancer Elements><Enhancers><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic><Genetic Abnormality><Genetic Change><Genetic Enhancer Element><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genomics><Goals><Hi-C><Histone-Lysine Methyltransferase><Histone-Lysine N-Methyltransferase><Human><Immune Precipitation><Immunoprecipitation><Infantile Autism><Intervention><Investigation><KG1T><KIAA0067><Kanner's Syndrome><Knowledge><Laboratories><Methylation><Methyltransferase><Modeling><Modern Man><Molecular><Molecular Abnormality><Molecular Interaction><Motivation><Mutate><Mutation><Nature><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neuroectoderm><Neurologic Disorders><Neurological Development Disorder><Neurological Disorders><Neuronal Differentiation><Neuronal Dysfunction><Neurons><Neurophysiology / Electrophysiology><Phenotype><Physiologic><Physiological><Property><Protein Lysine Methyltransferase><Protein Methylase III><Protein Methyltransferase III><Proteins><Proteomics><RNA Expression><Regimen><Regulatory Protein><Repression><Research><SETDB1><SETDB1 gene><Source><Technology><Testing><Therapeutic Intervention><Transcription><Transcriptional Control><Transcriptional Regulation><Visualization><Work><assess effectiveness><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><cell type><chromatin modifier><clinical relevance><clinically relevant><cofactor><determine effectiveness><developmental><directed differentiation><effectiveness assessment><effectiveness evaluation><electrophysiological><enhancer sequence><epigenetically><evaluate effectiveness><examine effectiveness><experiment><experimental research><experimental study><experiments><gene locus><genetic approach><genetic enhancer sequence><genetic locus><genetic regulatory protein><genetic strategy><genome mutation><genomic location><genomic locus><hESC><human ES cell><human ESC><human derived pluripotent stem cell><human embryonic stem cell><human pluripotent stem cell><human progenitor><human stem cells><insight><intervention therapy><loss of function><loss of function mutation><methylase><molecular aberrations><molecular pathology><neural dysfunction><neurodevelopmental disease><neurogenesis><neurological disease><neuronal><new diagnostics><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation diagnostics><novel><novel diagnostics><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pharmacologic><prevent><preventing><progenitor><progenitor cell differentiation><progenitor differentiation><regulatory gene product><restoration><stem and progenitor differentiation><stem cell differentiation><therapeutic target><three dimensional><transcriptomics><transmethylase>

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SUZEE EURIE LEE

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$780,302

FY 2026

Project Title

Neurodevelopment in children from families with genetic frontotemporal dementia and Alzheimer’s disease

Grant Number:

5R01AG071756-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT The current conceptualization of genetic frontotemporal dementia (FTD) and Alzheimer's disease (AD) is that they are neurodegenerative diseases with symptoms developing later in life. Yet, studies in animal models support the notion that autosomal dominant genes whose mutati...

Research Terms

<0-11 years old><13 year old><13 years of age><18 year old><18 years of age><21+ years old><AD dementia><AD/HD><ADHD><ASD><Adult><Adult Human><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Animal Model><Animal Models and Related Studies><Attention><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Behavioral Symptoms><Bilateral><Biological Markers><Biology><Brain><Brain Nervous System><Central Lobe><Child><Child Youth><Children (0-21)><Clinical><Cognitive><Cognitive Manifestations><Cognitive Symptoms><Corpus Striatum><Corpus striatum structure><Cross-Sectional Studies><Cross-Sectional Survey><DNA mutation><Data><Degenerative Neurologic Disorders><Differential Diagnosis><Disease><Disease Frequency Surveys><Disorder><Dominant Genes><Dyslexia><Early Infantile Autism><Early identification><Encephalon><FTD dementia><Family><Family member><Frontal Temporal Dementia><Frontotemporal Dementia><Functional MRI><Functional Magnetic Resonance Imaging><Genetic><Genetic Change><Genetic defect><Genetic mutation><Human><Infantile Autism><Inferior><Insula><Insula of Reil><Island of Reil><Kanner's Syndrome><Language><Learning Disabilities><Learning disability><Left><Memory><Mesulam Syndrome><Modeling><Modern Man><Mutation><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural Development><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurodevelopmental Disorder><Neurologic Degenerative Conditions><Neurological Development Disorder><PSEN1><Pattern><Performance><Phase><Play><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Primary Progressive Aphasia><Primary Senile Degenerative Dementia><Research Resources><Resources><Role><S182 protein><Striate Body><Striatum><Structure><Symptoms><Syndrome><Word Blindness><Work><adult youth><adulthood><age 13><age 13 years><age 18><age 18 years><amygdaloid nuclear complex><autism spectral disorder><autism spectrum disorder><autistic children><autistic spectrum disorder><autosome><behavior measurement><behavioral measure><behavioral measurement><behavioral variant FTD><behavioral variant frontotemporal degeneration><behavioral variant frontotemporal dementia><bio-markers><biologic marker><biomarker><bvFTD><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><compare to control><comparison control><cross-sectional research study><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><disease causing variant><disease-causing allele><disease-causing mutation><early biomarkers><early detection biomarkers><early detection markers><eighteen year old><eighteen years of age><executive control><executive function><fMRI><front temporal dementia><frontal cortex><frontal lobe><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><genome mutation><gray matter><insight><kids><late in life><late life><later in life><later life><life span><lifespan><model of animal><mutation carrier><neural circuit><neural circuitry><neural imaging><neural network><neuro-imaging><neurocircuitry><neurodegenerative illness><neurodevelopment><neurodevelopmental disease><neuroimaging><neurological imaging><pathogenic allele><pathogenic variant><presenilin 1 protein><presenilin-1><primary degenerative dementia><senile dementia of the Alzheimer type><social role><striatal><substantia alba><substantia grisea><synaptic circuit><synaptic circuitry><thirteen year old><thirteen years of age><white matter><young adult><young adult age><young adulthood><youngster>

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Christine Wu Nordahl

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$777,651

FY 2026

Project Title

Neural and developmental trajectories of females with autism spectrum disorder

Grant Number:

5R01MH127046-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Girls and women are understudied in autism spectrum disorder (ASD) research because study samples often reflect the male predominance in ASD prevalence, with 3-4 boys diagnosed for every girl. Longitudinal imaging studies with sufficient numbers of females are completely lacking. To address this imp...

Research Terms

<12 year old><12 years of age><6 year old><6 years of age><6-11 years old><AD/HD><ADHD><ASD><Address><Age><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Area><Attention deficit hyperactivity disorder><Attenuated><Autism><Autistic Disorder><Behavioral><Brain><Brain Nervous System><Brain region><Caring><Causality><Data><Deliberate Self-Harm><Department of Health and Human Services><Detection><Development><Diagnosis><Diagnostic><Differences between sexes><Differs between sexes><Disease><Disorder><Disproportionate number of men><Disproportionately impacts males><Disproportionately in men><Early Infantile Autism><Emotional><Encephalon><Enrollment><Etiology><Exhibits><Female><Female Health><General Population><General Public><Goals><Hyperactivity><Impulsivity><Infantile Autism><Kanner's Syndrome><Knowledge><Literature><Long-term cohort><Longitudinal Studies><Longitudinal Surveys><Longitudinal cohort><Medicine><Modeling><Motor><NIH><National Institutes of Health><Participant><Pattern><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prevalence><Protocol><Protocols documentation><Psychopathology><Research><Risk Factors><Sampling><Sampling Studies><Self-Injurious Behavior><Sensory><Sex Differences><Sexual differences><Strategic Planning><Symptoms><System><Testing><Theoretic Models><Theoretical model><Time><United States Department of Health and Human Services><United States Dept. of Health and Human Services><United States National Institutes of Health><Woman><Women's Health><abnormal psychology><age 12><age 12 years><age 6><age 6 years><ages><amygdaloid nuclear complex><attenuate><attenuates><attenuation><autism attributes><autism biomarker><autism indicator><autism marker><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><behavior phenotype><behavioral phenotyping><boys><causation><cohort><cohort investigation><cohort research><deliberate self harm><developmental><diagnosis among females><diagnosis among women><diagnosis in females><diagnosis in women><diagnosis within females><diagnosis within women><disease causation><disease risk><disorder risk><disproportionately affects males><disproportionately affects men><disproportionately concentrated among men><disproportionately distributed among men><disproportionately higher among men><disproportionately impacts men><disproportionately occurs in men><early childhood><emotion dysregulation><emotion regulation><emotional dysregulation><emotional regulation><enroll><externalizing behavior><female diagnosis><girls><imaging study><inattention><inattentiveness><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><insight><intentional self harm><intentional self injury><investigate cohort><life span><lifespan><long-term study><longitudinal imaging><longitudinal outcome studies><longitudinal research study><male><male bias><male predominance><men disproportionately diagnosed><men disproportionately experience><men experience disproportionate rates><middle childhood><neural><neural imaging><neuro-imaging><neuroimaging><neurological imaging><optimal therapies><optimal treatments><outcome prediction><peer><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><phenome><predominantly affecting men><programs><protective effect><recruit><repetitive behavior><self harm><self injury><serial imaging><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><six year old><six years of age><study cohort><survey cohort><theories><twelve year old><twelve years of age><women's diagnosis><♀><♂>

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Seth Abrams Ament

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$762,566

FY 2026

Project Title

Quantifying cerebellar multi-omic and synaptic features of autism spectrum disorders

Grant Number:

1R01MH139606-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Strong, longstanding evidence points to important roles for the cerebellum in autism spectrum disorders (ASDs), yet cerebellar mechanisms remain understudied in ASDs compared to neocortical circuits. Anatomical and functional studies have pointed, in particular, to changes in the syn...

Research Terms

<21+ years old><ASD><Address><Adult><Adult Human><Age><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Autism><Autistic Disorder><Autopsy><Baltimore><Behavior-Related Disorder><Behavior-Related Problem><Body Tissues><Bourneville Disease><Bourneville Phakomatosis><Bourneville syndrome><Bourneville-Brissaud disease><Bourneville-Pringle syndrome><Brain><Brain Nervous System><Cell Body><Cell Nucleus><Cells><Cerebellar vermis structure><Cerebellum><Cerebroatrophic Hyperammonemia><Chromatin><Chromosome Mapping><Cognition><DNA mutation><Data><Data Set><Dendrites><Development><Diagnosis><Early Infantile Autism><Emotional><Encephalon><Epiloia><Escalante syndrome><Fiber><Fragile X><Fragile X Syndrome><Gene Action Regulation><Gene Down-Regulation><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Expression Regulation><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Organization><Gene Regulation><Gene Regulation Process><Gene Structure><Gene Structure/Organization><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Glia><Glial Cells><Hamartin><Heterogeneity><Human><Image><Individual><Infantile Autism><KO mice><Kanner's Syndrome><Knock-out Mice><Knockout Mice><Knowledge><Kolliker's reticulum><Lifestyle-Related Disorder><Lifestyle-Related Problem><Lifestyle-related condition><Linkage Mapping><LoxP-flanked allele><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Maryland><Mice><Mice Mammals><Microscopy><Modern Man><Morphology><Murine><Mus><Mutation><Nanostructures><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Non-neuronal cell><Nonneuronal cell><Nucleus><Null Mouse><Output><Phenotype><Physiology><Population><Pringle disease><Purkinje Cells><Purkinje's Corpuscles><RNA Expression><Renpenning syndrome 2><Research Resources><Research Specimen><Resources><Rett Disorder><Rett Syndrome><Risk-associated variant><Role><Sampling><Single-Nucleus Sequencing><Social Behavior><Specimen><Structure><Subgroup><Synapses><Synaptic><TSC1><TSC1 gene><Testing><Tissue Banks><Tissue Collection><Tissue Sample><Tissue repository><Tissues><Total Human and Non-Human Gene Mapping><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Transcription Repression><Translating><Tuberous Sclerosis><University resources><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><adenoma sebaceum><adulthood><ages><analyze gene expression><autism attributes><autism indicator><autism model><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-fragile X (AFRAX) syndrome><autism-like symptoms><autism-related attributes><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><brain tissue><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cell imaging><cell type><cellular imaging><cerebellar Purkinje cell><cerebral sclerosis><cohort><conditional knock-out><conditional knockout><confocal imaging><density><developmental><epigenomics><epiploia><experiment><experimental research><experimental study><experiments><floxed><floxed allele><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><functional status><gene expression analysis><gene expression assay><gene network><gene regulatory network><gene repression><genes structure><genetic mapping><genome mutation><global gene expression><global transcription profile><granule cell><hereditary multiple system hamartomatosis><human data><imaging><imaging study><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><insight><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><model of animal><model of autism spectrum disorder><mouse model><multiomics><multiple omics><murine model><nano meter scale><nano meter sized><nano-sized structures><nano-structures><nanometer scale><nanometer sized><nanoscale><necropsy><neocortical><nerve cement><network models><neurinomatosis centralis><neurobiological mechanism><neuromatosis universalis><neuronal><neuropathologic><neuropathological><neuropathology><neurospongioblastosis diffusa><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><panomics><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><phacomatosis><postmortem><postsynaptic><public health relevance><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sNuc-Seq><sclerosis tuberosa><sex><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><sociobehavior><sociobehavioral><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><spongioblastosis circumscripta><super high resolution><superresolution><synapse><synapse function><synaptic function><trait><transcriptional profiling><transcriptome><transcriptomics><tuberose sclerosis><tuberous sclerosis 1><tuberous sclerosis complex><ultra high resolution><vermis>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Thomas A Blanpied

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$762,566

FY 2026

Project Title

Quantifying cerebellar multi-omic and synaptic features of autism spectrum disorders

Grant Number:

1R01MH139606-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Strong, longstanding evidence points to important roles for the cerebellum in autism spectrum disorders (ASDs), yet cerebellar mechanisms remain understudied in ASDs compared to neocortical circuits. Anatomical and functional studies have pointed, in particular, to changes in the syn...

Research Terms

<21+ years old><ASD><Address><Adult><Adult Human><Age><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Autism><Autistic Disorder><Autopsy><Baltimore><Behavior-Related Disorder><Behavior-Related Problem><Body Tissues><Bourneville Disease><Bourneville Phakomatosis><Bourneville syndrome><Bourneville-Brissaud disease><Bourneville-Pringle syndrome><Brain><Brain Nervous System><Cell Body><Cell Nucleus><Cells><Cerebellar vermis structure><Cerebellum><Cerebroatrophic Hyperammonemia><Chromatin><Chromosome Mapping><Cognition><DNA mutation><Data><Data Set><Dendrites><Development><Diagnosis><Early Infantile Autism><Emotional><Encephalon><Epiloia><Escalante syndrome><Fiber><Fragile X><Fragile X Syndrome><Gene Action Regulation><Gene Down-Regulation><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Expression Regulation><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Organization><Gene Regulation><Gene Regulation Process><Gene Structure><Gene Structure/Organization><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Glia><Glial Cells><Hamartin><Heterogeneity><Human><Image><Individual><Infantile Autism><KO mice><Kanner's Syndrome><Knock-out Mice><Knockout Mice><Knowledge><Kolliker's reticulum><Lifestyle-Related Disorder><Lifestyle-Related Problem><Lifestyle-related condition><Linkage Mapping><LoxP-flanked allele><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Maryland><Mice><Mice Mammals><Microscopy><Modern Man><Morphology><Murine><Mus><Mutation><Nanostructures><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Non-neuronal cell><Nonneuronal cell><Nucleus><Null Mouse><Output><Phenotype><Physiology><Population><Pringle disease><Purkinje Cells><Purkinje's Corpuscles><RNA Expression><Renpenning syndrome 2><Research Resources><Research Specimen><Resources><Rett Disorder><Rett Syndrome><Risk-associated variant><Role><Sampling><Single-Nucleus Sequencing><Social Behavior><Specimen><Structure><Subgroup><Synapses><Synaptic><TSC1><TSC1 gene><Testing><Tissue Banks><Tissue Collection><Tissue Sample><Tissue repository><Tissues><Total Human and Non-Human Gene Mapping><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Transcription Repression><Translating><Tuberous Sclerosis><University resources><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><adenoma sebaceum><adulthood><ages><analyze gene expression><autism attributes><autism indicator><autism model><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-fragile X (AFRAX) syndrome><autism-like symptoms><autism-related attributes><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><brain tissue><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cell imaging><cell type><cellular imaging><cerebellar Purkinje cell><cerebral sclerosis><cohort><conditional knock-out><conditional knockout><confocal imaging><density><developmental><epigenomics><epiploia><experiment><experimental research><experimental study><experiments><floxed><floxed allele><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><functional status><gene expression analysis><gene expression assay><gene network><gene regulatory network><gene repression><genes structure><genetic mapping><genome mutation><global gene expression><global transcription profile><granule cell><hereditary multiple system hamartomatosis><human data><imaging><imaging study><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><insight><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><model of animal><model of autism spectrum disorder><mouse model><multiomics><multiple omics><murine model><nano meter scale><nano meter sized><nano-sized structures><nano-structures><nanometer scale><nanometer sized><nanoscale><necropsy><neocortical><nerve cement><network models><neurinomatosis centralis><neurobiological mechanism><neuromatosis universalis><neuronal><neuropathologic><neuropathological><neuropathology><neurospongioblastosis diffusa><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><panomics><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><phacomatosis><postmortem><postsynaptic><public health relevance><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sNuc-Seq><sclerosis tuberosa><sex><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><sociobehavior><sociobehavioral><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><spongioblastosis circumscripta><super high resolution><superresolution><synapse><synapse function><synaptic function><trait><transcriptional profiling><transcriptome><transcriptomics><tuberose sclerosis><tuberous sclerosis 1><tuberous sclerosis complex><ultra high resolution><vermis>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Tomasz Nowakowski

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$754,771

FY 2026

Project Title

Neurodevelopmental defects of the thalamocortical pathway as a convergent feature of psychiatric disorders

Grant Number:

5R01MH128364-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Brain function emerges from the activity of hundreds of neuronal types embedded within a complex network of neural circuits. Although the formation of neural circuits is guided by the emergent activity, many of the initial ‘wiring instructions’ are genetically encoded. Mutations in g...

Research Terms

<22q11><22q11 Chromosomal Microdeletion Syndrome><22q11 Deletion Syndrome><22q11.2><22q11.2 deletion syndrome><22q11.2DS><22q11DS><AD/HD><ADHD><ASD><Assay><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Autosomal dominant Opitz G/BBB syndrome><Axon><Basal Transcription Factor><Basal transcription factor genes><Benchmarking><Best Practice Analysis><Bioassay><Biological Assay><Body Tissues><Brain><Brain Nervous System><CAGH44><CRISPR><CRISPR/Cas system><Calcium><Cayler cardiofacial syndrome><Cell Body><Cell Line><Cell Nucleus><CellLine><Cells><Cerebral cortex><Chromosomal microdeletion><Chromosome 22q11.2 deletion syndrome><Clustered Regularly Interspaced Short Palindromic Repeats><Complex><DNA mutation><Data><Data Set><Defect><Dejerine Roussy Syndrome><Dejerine-Roussy Syndrome><Development><Developmental Delay><Developmental Delay Disorders><Di George syndrome><DiGeorge Syndrome><DiGeorge anomaly><DiGeorge sequence><Differentiation in cell culture><Disease><Disorder><Dysfunction><Dyskinesia Syndromes><Early Infantile Autism><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><FOXP2><FOXP2 gene><Fiber><Forkhead Box P2><Functional disorder><Gene Expression><Gene variant><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Genetic Change><Genetic defect><Genetic mutation><Genetic study><Glia><Glial Cells><Glutamates><Goals><Growth><Heterozygote><Human><Human Development><Image><In vitro cell differentiation><Individual><Infantile Autism><Instruction><Investigation><Kanner's Syndrome><Kolliker's reticulum><L-Glutamate><Mediating><Mental disorders><Mental health disorders><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Motor><Movement Disorder Syndromes><Movement Disorders><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurological Development Disorder><Neuronal Differentiation><Neurons><Non-neuronal cell><Nonneuronal cell><Nucleus><Organoids><Pathway interactions><Patients><Phenotype><Physiopathology><Pluripotent Stem Cells><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Process><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Radial><Radius><Role><Schizophrenia><Schizophrenic Disorders><Sedlackova syndrome><Seizure Disorder><Sensory><Series><Shprintzen syndrome><Single cell seq><Specific Child Development Disorders><Specific qualifier value><Specificity><Specified><Strains Cell Lines><Study models><Syndrome><TNRC10><Technology><Testing><Thalamic structure><Thalamic syndrome><Thalamus><Tissue Growth><Tissue Model><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Trinucleotide Repeat-Containing Gene 10><Work><allelic variant><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><benchmark><cell fate specification><cell type><cognitive task><conotruncal anomaly face syndrome><cultured cell line><dementia praecox><developmental><differentiation in culture><differentiation in vitro><differentiation protocol><epigenomics><epilepsia><epileptogenic><exome sequencing><exome-seq><familial third and fourth pharyngeal pouch syndrome><genetic variant><genome mutation><genomic data><genomic dataset><genomic variant><glutamatergic><heterozygosity><human derived pluripotent stem cell><human model><human pluripotent stem cell><human tissue><iPS><iPSC><iPSCs><imaging><in vitro cellular differentiation><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><knock-down><knockdown><mental illness><microdeletion><model of human><mouse development><mouse model><murine model><nerve cement><neural><neural circuit><neural circuitry><neural imaging><neural patterning><neuro-imaging><neurocircuitry><neurodevelopmental disease><neuroimaging><neurological imaging><neuronal><neuropsychiatric symptom><ontogeny><overexpress><overexpression><pathophysiology><pathway><pharyngeal pouch syndrome><pluripotent progenitor><preference><progenitor cell model><progenitor model><psychiatric illness><psychological disorder><scRNA sequencing><scRNA-seq><schizophrenic><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell next generation sequencing><single cell sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stem cell technology><synaptic circuit><synaptic circuitry><thalamic><thalamic radiation><thalamocortical tract><third and fourth pharyngeal pouch syndrome><thymic and parathyroid agenesis syndrome><tool><transcription factor><transcriptomics><velo-cardio-facial syndrome><velocardiofacial syndrome><velofacial hypoplasia>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JOHN L. R. RUBENSTEIN

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$754,771

FY 2026

Project Title

Neurodevelopmental defects of the thalamocortical pathway as a convergent feature of psychiatric disorders

Grant Number:

5R01MH128364-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Brain function emerges from the activity of hundreds of neuronal types embedded within a complex network of neural circuits. Although the formation of neural circuits is guided by the emergent activity, many of the initial ‘wiring instructions’ are genetically encoded. Mutations in g...

Research Terms

<22q11><22q11 Chromosomal Microdeletion Syndrome><22q11 Deletion Syndrome><22q11.2><22q11.2 deletion syndrome><22q11.2DS><22q11DS><AD/HD><ADHD><ASD><Assay><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Autosomal dominant Opitz G/BBB syndrome><Axon><Basal Transcription Factor><Basal transcription factor genes><Benchmarking><Best Practice Analysis><Bioassay><Biological Assay><Body Tissues><Brain><Brain Nervous System><CAGH44><CRISPR><CRISPR/Cas system><Calcium><Cayler cardiofacial syndrome><Cell Body><Cell Line><Cell Nucleus><CellLine><Cells><Cerebral cortex><Chromosomal microdeletion><Chromosome 22q11.2 deletion syndrome><Clustered Regularly Interspaced Short Palindromic Repeats><Complex><DNA mutation><Data><Data Set><Defect><Dejerine Roussy Syndrome><Dejerine-Roussy Syndrome><Development><Developmental Delay><Developmental Delay Disorders><Di George syndrome><DiGeorge Syndrome><DiGeorge anomaly><DiGeorge sequence><Differentiation in cell culture><Disease><Disorder><Dysfunction><Dyskinesia Syndromes><Early Infantile Autism><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><FOXP2><FOXP2 gene><Fiber><Forkhead Box P2><Functional disorder><Gene Expression><Gene variant><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Genetic Change><Genetic defect><Genetic mutation><Genetic study><Glia><Glial Cells><Glutamates><Goals><Growth><Heterozygote><Human><Human Development><Image><In vitro cell differentiation><Individual><Infantile Autism><Instruction><Investigation><Kanner's Syndrome><Kolliker's reticulum><L-Glutamate><Mediating><Mental disorders><Mental health disorders><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Motor><Movement Disorder Syndromes><Movement Disorders><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurological Development Disorder><Neuronal Differentiation><Neurons><Non-neuronal cell><Nonneuronal cell><Nucleus><Organoids><Pathway interactions><Patients><Phenotype><Physiopathology><Pluripotent Stem Cells><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Process><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Radial><Radius><Role><Schizophrenia><Schizophrenic Disorders><Sedlackova syndrome><Seizure Disorder><Sensory><Series><Shprintzen syndrome><Single cell seq><Specific Child Development Disorders><Specific qualifier value><Specificity><Specified><Strains Cell Lines><Study models><Syndrome><TNRC10><Technology><Testing><Thalamic structure><Thalamic syndrome><Thalamus><Tissue Growth><Tissue Model><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Trinucleotide Repeat-Containing Gene 10><Work><allelic variant><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><benchmark><cell fate specification><cell type><cognitive task><conotruncal anomaly face syndrome><cultured cell line><dementia praecox><developmental><differentiation in culture><differentiation in vitro><differentiation protocol><epigenomics><epilepsia><epileptogenic><exome sequencing><exome-seq><familial third and fourth pharyngeal pouch syndrome><genetic variant><genome mutation><genomic data><genomic dataset><genomic variant><glutamatergic><heterozygosity><human derived pluripotent stem cell><human model><human pluripotent stem cell><human tissue><iPS><iPSC><iPSCs><imaging><in vitro cellular differentiation><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><knock-down><knockdown><mental illness><microdeletion><model of human><mouse development><mouse model><murine model><nerve cement><neural><neural circuit><neural circuitry><neural imaging><neural patterning><neuro-imaging><neurocircuitry><neurodevelopmental disease><neuroimaging><neurological imaging><neuronal><neuropsychiatric symptom><ontogeny><overexpress><overexpression><pathophysiology><pathway><pharyngeal pouch syndrome><pluripotent progenitor><preference><progenitor cell model><progenitor model><psychiatric illness><psychological disorder><scRNA sequencing><scRNA-seq><schizophrenic><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell next generation sequencing><single cell sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stem cell technology><synaptic circuit><synaptic circuitry><thalamic><thalamic radiation><thalamocortical tract><third and fourth pharyngeal pouch syndrome><thymic and parathyroid agenesis syndrome><tool><transcription factor><transcriptomics><velo-cardio-facial syndrome><velocardiofacial syndrome><velofacial hypoplasia>

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Vikaas Singh Sohal

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$754,771

FY 2026

Project Title

Neurodevelopmental defects of the thalamocortical pathway as a convergent feature of psychiatric disorders

Grant Number:

5R01MH128364-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Brain function emerges from the activity of hundreds of neuronal types embedded within a complex network of neural circuits. Although the formation of neural circuits is guided by the emergent activity, many of the initial ‘wiring instructions’ are genetically encoded. Mutations in g...

Research Terms

<22q11><22q11 Chromosomal Microdeletion Syndrome><22q11 Deletion Syndrome><22q11.2><22q11.2 deletion syndrome><22q11.2DS><22q11DS><AD/HD><ADHD><ASD><Assay><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Autosomal dominant Opitz G/BBB syndrome><Axon><Basal Transcription Factor><Basal transcription factor genes><Benchmarking><Best Practice Analysis><Bioassay><Biological Assay><Body Tissues><Brain><Brain Nervous System><CAGH44><CRISPR><CRISPR/Cas system><Calcium><Cayler cardiofacial syndrome><Cell Body><Cell Line><Cell Nucleus><CellLine><Cells><Cerebral cortex><Chromosomal microdeletion><Chromosome 22q11.2 deletion syndrome><Clustered Regularly Interspaced Short Palindromic Repeats><Complex><DNA mutation><Data><Data Set><Defect><Dejerine Roussy Syndrome><Dejerine-Roussy Syndrome><Development><Developmental Delay><Developmental Delay Disorders><Di George syndrome><DiGeorge Syndrome><DiGeorge anomaly><DiGeorge sequence><Differentiation in cell culture><Disease><Disorder><Dysfunction><Dyskinesia Syndromes><Early Infantile Autism><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><FOXP2><FOXP2 gene><Fiber><Forkhead Box P2><Functional disorder><Gene Expression><Gene variant><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Genetic Change><Genetic defect><Genetic mutation><Genetic study><Glia><Glial Cells><Glutamates><Goals><Growth><Heterozygote><Human><Human Development><Image><In vitro cell differentiation><Individual><Infantile Autism><Instruction><Investigation><Kanner's Syndrome><Kolliker's reticulum><L-Glutamate><Mediating><Mental disorders><Mental health disorders><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Motor><Movement Disorder Syndromes><Movement Disorders><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurological Development Disorder><Neuronal Differentiation><Neurons><Non-neuronal cell><Nonneuronal cell><Nucleus><Organoids><Pathway interactions><Patients><Phenotype><Physiopathology><Pluripotent Stem Cells><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Process><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Radial><Radius><Role><Schizophrenia><Schizophrenic Disorders><Sedlackova syndrome><Seizure Disorder><Sensory><Series><Shprintzen syndrome><Single cell seq><Specific Child Development Disorders><Specific qualifier value><Specificity><Specified><Strains Cell Lines><Study models><Syndrome><TNRC10><Technology><Testing><Thalamic structure><Thalamic syndrome><Thalamus><Tissue Growth><Tissue Model><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Trinucleotide Repeat-Containing Gene 10><Work><allelic variant><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><benchmark><cell fate specification><cell type><cognitive task><conotruncal anomaly face syndrome><cultured cell line><dementia praecox><developmental><differentiation in culture><differentiation in vitro><differentiation protocol><epigenomics><epilepsia><epileptogenic><exome sequencing><exome-seq><familial third and fourth pharyngeal pouch syndrome><genetic variant><genome mutation><genomic data><genomic dataset><genomic variant><glutamatergic><heterozygosity><human derived pluripotent stem cell><human model><human pluripotent stem cell><human tissue><iPS><iPSC><iPSCs><imaging><in vitro cellular differentiation><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><knock-down><knockdown><mental illness><microdeletion><model of human><mouse development><mouse model><murine model><nerve cement><neural><neural circuit><neural circuitry><neural imaging><neural patterning><neuro-imaging><neurocircuitry><neurodevelopmental disease><neuroimaging><neurological imaging><neuronal><neuropsychiatric symptom><ontogeny><overexpress><overexpression><pathophysiology><pathway><pharyngeal pouch syndrome><pluripotent progenitor><preference><progenitor cell model><progenitor model><psychiatric illness><psychological disorder><scRNA sequencing><scRNA-seq><schizophrenic><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell next generation sequencing><single cell sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><stem cell technology><synaptic circuit><synaptic circuitry><thalamic><thalamic radiation><thalamocortical tract><third and fourth pharyngeal pouch syndrome><thymic and parathyroid agenesis syndrome><tool><transcription factor><transcriptomics><velo-cardio-facial syndrome><velocardiofacial syndrome><velofacial hypoplasia>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

James Charles McPartland

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$753,418

FY 2026

Project Title

Improving inclusion of individuals with intellectual disability in autism neuroscience research

Grant Number:

5R01MH138485-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Individuals with autism and intellectual disability (ASD+ID) comprise a significant portion of the autism spectrum but have historically been excluded from most neuroscience research. As a result, little is understood about differences in brain function among those with the ...

Research Terms

<0-11 years old><6-11 years old><ASD><Acclimatization><Active Follow-up><Activities of Daily Living><Activities of everyday life><Adaptive Behaviors><Address><Affect><Artifacts><Assay><Attenuated><Autism><Autistic Disorder><BCBA><Behavior><Behavioral><Bioassay><Biological Assay><Brain><Brain Nervous System><Calibration><Care Givers><Caregivers><Characteristics><Child><Child Youth><Children (0-21)><Clinical><Clinical Research><Clinical Study><Clinical Trials><Collection><Communities><Computer Vision Systems><Computer software><Coupled><Data><Data Collection><EEG><Early Infantile Autism><Electroencephalogram><Electroencephalography><Encephalon><Environment><Evaluation><Event-Related Potentials><Exclusion><Face><Feedback><Fixation><Foundations><Goals><High Prevalence><Human><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Investigators><Kanner's Syndrome><Knowledge><Laboratories><Measures><Meta-Analysis><Methods><Modern Man><Morphologic artifacts><Motion><Movement><Neurosciences><Neurosciences Research><Participant><Population><Prevalence><Protocol><Protocols documentation><Psychometrics><Publishing><Research><Research Personnel><Researchers><Rewards><Sampling><Scalp><Scalp structure><School-Age Population><Severities><Site><Software><Specific qualifier value><Specified><Stratification><Subgroup><Technology><Testing><Time><Visual attention><Work><active followup><adaptation behavior><adaptive behavior><attenuate><attenuates><autism biomarker><autism diagnostic observation schedule><autism marker><autism spectral disorder><autism spectrum disorder><autistic><autistic children><autistic individuals><autistic people><autistic spectrum disorder><base><bases><board certified behavior analyst><body movement><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cognitive ability><computer vision><daily living function><daily living functionality><data quality><data streams><design><designing><epidemiology research study><epidemiology study><epidemiology survey><ergonomics><event related potential><experiment><experimental research><experimental study><experiments><eye tracking><faces><facial><follow up><follow-up><followed up><followup><functional ability><functional capacity><improved><indexing><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><innovate><innovation><innovative><innovative technologies><insight><intellectual and developmental disability><kids><limited intellectual functioning><meeting><meetings><middle childhood><multi-modal data><multi-modal datasets><multi-modality><multimodal data><multimodal datasets><multimodality><neural><neurobehavioral><novel><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><profound autism><reinforcer><response><response to therapy><response to treatment><sample fixation><school age><social><social communication><stem><symptomatology><therapeutic response><therapy response><treatment response><treatment responsiveness><visual tracking><youngster>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Adam john Naples

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$753,418

FY 2026

Project Title

Improving inclusion of individuals with intellectual disability in autism neuroscience research

Grant Number:

5R01MH138485-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Individuals with autism and intellectual disability (ASD+ID) comprise a significant portion of the autism spectrum but have historically been excluded from most neuroscience research. As a result, little is understood about differences in brain function among those with the ...

Research Terms

<0-11 years old><6-11 years old><ASD><Acclimatization><Active Follow-up><Activities of Daily Living><Activities of everyday life><Adaptive Behaviors><Address><Affect><Artifacts><Assay><Attenuated><Autism><Autistic Disorder><BCBA><Behavior><Behavioral><Bioassay><Biological Assay><Brain><Brain Nervous System><Calibration><Care Givers><Caregivers><Characteristics><Child><Child Youth><Children (0-21)><Clinical><Clinical Research><Clinical Study><Clinical Trials><Collection><Communities><Computer Vision Systems><Computer software><Coupled><Data><Data Collection><EEG><Early Infantile Autism><Electroencephalogram><Electroencephalography><Encephalon><Environment><Evaluation><Event-Related Potentials><Exclusion><Face><Feedback><Fixation><Foundations><Goals><High Prevalence><Human><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Investigators><Kanner's Syndrome><Knowledge><Laboratories><Measures><Meta-Analysis><Methods><Modern Man><Morphologic artifacts><Motion><Movement><Neurosciences><Neurosciences Research><Participant><Population><Prevalence><Protocol><Protocols documentation><Psychometrics><Publishing><Research><Research Personnel><Researchers><Rewards><Sampling><Scalp><Scalp structure><School-Age Population><Severities><Site><Software><Specific qualifier value><Specified><Stratification><Subgroup><Technology><Testing><Time><Visual attention><Work><active followup><adaptation behavior><adaptive behavior><attenuate><attenuates><autism biomarker><autism diagnostic observation schedule><autism marker><autism spectral disorder><autism spectrum disorder><autistic><autistic children><autistic individuals><autistic people><autistic spectrum disorder><base><bases><board certified behavior analyst><body movement><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cognitive ability><computer vision><daily living function><daily living functionality><data quality><data streams><design><designing><epidemiology research study><epidemiology study><epidemiology survey><ergonomics><event related potential><experiment><experimental research><experimental study><experiments><eye tracking><faces><facial><follow up><follow-up><followed up><followup><functional ability><functional capacity><improved><indexing><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><innovate><innovation><innovative><innovative technologies><insight><intellectual and developmental disability><kids><limited intellectual functioning><meeting><meetings><middle childhood><multi-modal data><multi-modal datasets><multi-modality><multimodal data><multimodal datasets><multimodality><neural><neurobehavioral><novel><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><profound autism><reinforcer><response><response to therapy><response to treatment><sample fixation><school age><social><social communication><stem><symptomatology><therapeutic response><therapy response><treatment response><treatment responsiveness><visual tracking><youngster>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Eakta Jain

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$741,476

FY 2026

Project Title

AVAIL: Anonymization of Videos using AI for Large scale data sharing

Grant Number:

5R01MH136195-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/13/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Children with autism spectrum disorders (ASD) benefit from specialized services throughout their lifespan. However, autism assessment, treatment, and care are bottlenecked by clinician availability. While it is important to continue to seek to expand the ASD-healthcare workf...

Research Terms

<0-11 years old><12 year old><12 years of age><21+ years old><AI Augmented><AI assisted><AI driven><AI enhanced><AI integrated><AI powered><ASD><ASD community><Acceleration><Address><Administrator><Adult><Adult Human><Age><Algorithms><Architecture><Area><Artificial Intelligence enhanced><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Authorization><Authorization documentation><Autism><Autistic Disorder><Behavior><Behavior Disorders><Behavior assessment><Behavioral><Care Givers><Caregivers><Caring><Child><Child Youth><Children (0-21)><Communities><Computing Methodologies><Connectionist Models><Crowding><Data><Data Set><Detection><Development><Diagnosis><Diagnostic><Drops><Early Infantile Autism><Ecologic Systems><Ecological Systems><Ecosystem><Education and Training><Educational Materials><Effectiveness><Engineering / Architecture><Equilibrium><Evaluation><Face><Facial Expression><Family><Feedback><Focus Groups><Geometry><Goals><Guidelines><Head><Health Care Providers><Health Personnel><Human><Infantile Autism><Injections><Investigation><Investigators><Kanner's Syndrome><Knowledge><Lived experience><Lived experiences><Machine Learning><Measures><Mental Health><Mental Hygiene><Methods><Modeling><Modern Man><Nature><Network-based><Neural Network Models><Neural Network Simulation><Outcome Study><Parents><Patient Recruitments><Patients><Perceptrons><Performance><Permission><Privacy><Privatization><Process><Process Assessment><Psychological Health><Readability><Research><Research Personnel><Researchers><Rest><Semantics><Services><Severities><Surface><Survey Instrument><Surveys><Techniques><Testing><Text><Therapeutic><Training><Training and Education><Video Recording><Videorecording><Visual><Visualization><Voice><Work><adulthood><age 12><age 12 years><ages><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><autism community><autism spectral disorder><autism spectrum disorder><autism spectrum disorder community><autistic children><autistic spectrum disorder><balance><balance function><behavioral assessment><behavioral disorder><care giving><care providers><caregiving><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical training><computational methodology><computational methods><computer based method><computer methods><computing method><crowd source><crowd-sourcing><crowdsource><crowdsourcing><data heterogeneity><data set heterogeneity><data sharing><dataset heterogeneity><deep learning based neural network><deep learning neural network><deep neural net><deep neural network><design><designing><developmental><diagnostic tool><enhanced with AI><enhanced with Artificial Intelligence><expectation><face expression><faces><facial><gaze><generative models><health care personnel><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><heterogeneous data><heterogeneous data sets><heterogeneous datasets><heterogenous data><heterogenous data sets><heterogenous datasets><human-in-the-loop><improved><insight><kids><large scale data><large scale data sets><large scale datasets><life span><lifespan><machine based learning><medical care providers><medical personnel><microphone><neural net architecture><neural network architecture><novel><parent><participant recruitment><patient privacy><preservation><prototype><real world application><tool><treatment provider><twelve year old><twelve years of age><usability><user centered design><video recording system><youngster>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

VINCENT P FERRERA

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$736,314

FY 2026

Project Title

Focused ultrasound for memory disorders

Grant Number:

5R01MH133020-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary/Abstract Working memory (WM) is a core component of executive function. WM is impaired in conditions that affect roughly 20M people in the US alone, including Alzheimer’s disease (5.8M), Parkinson’s disease (1.2M), schizophrenia (1.5M), attention deficit hyperactivity disorder (6.1M) and aut...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD dementia><AD patients><AD/HD><ADHD><ASD><Abnormal Movements><Address><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease patient><Alzheimer's patient><Alzheimers Dementia><Amentia><Aminalon><Aminalone><Area><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Autopsy><Behavioral><Blood - brain barrier anatomy><Blood-Brain Barrier><Brain><Brain Nervous System><Brain region><Cerebellar Dysmetria><Chemicals><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive Retention Disorders><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Computer software><Contralateral><Corpus Striatum><Corpus striatum structure><Data><Decision Making><Deep Brain Stimulation><Dementia><Disturbance in cognition><Dorsal><Dose><Drug Delivery><Drug Delivery Systems><Drug Targeting><Drugs><Dyskinesias><Dyskinetic syndrome><Dysmetria><E-stim><Early Infantile Autism><Electric Stimulation><Encephalon><Focused Ultrasound><Focused Ultrasound Ablation><Focused Ultrasound Therapy><Focused Ultrasound Treatment><Frequencies><Functional MRI><Functional Magnetic Resonance Imaging><GABA><Goals><Hemato-Encephalic Barrier><High Power Focused Ultrasound><High-intensity focused ultrasound><Histology><Human><Hydrogen Oxide><Immediate Memory><Impaired cognition><Impairment><Infantile Autism><Intravenous><Ipsilateral><Kanner's Syndrome><Length><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Maps><Measures><Mediating><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Memory><Memory Deficit><Memory Disorders><Memory impairment><Mental disorders><Mental health disorders><Methods><Microbubbles><Modern Man><Motor><Motor Cortex><Movement><NMR Imaging><NMR Tomography><Nerve Transmitter Substances><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Neurotransmitters><Nuclear Magnetic Resonance Imaging><Nucleus Caudatus><Paralysis Agitans><Parkinson><Parkinson Disease><Patients><Performance><Perfusion><Persons><Pharmaceutical Preparations><Physiologic><Physiologic pulse><Physiological><Physiology><Predisposition><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prefrontal Cortex><Primary Parkinsonism><Primary Senile Degenerative Dementia><Psychiatric Disease><Psychiatric Disorder><Pulse><Research><Safety><Schizophrenia><Schizophrenic Disorders><Short-Term Memory><Software><Speed><Striate Body><Striatum><Structure><Susceptibility><Testing><Thermometry><Time><Tremor><Water><Work><Zeugmatography><arterial spin labeling><arterial spin tagging><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><awake><bloodbrain barrier><body movement><brain behavior><caudate nucleus><cognitive defects><cognitive dysfunction><cognitive loss><dementia praecox><drug/agent><effectiveness testing><electrostimulation><executive control><executive function><experience><experiment><experimental research><experimental study><experiments><fMRI><gamma-Aminobutyric Acid><human data><improved><intravenous injection><member><memory dysfunction><mental illness><necropsy><neural circuit><neural circuitry><neural control><neural regulation><neurocircuitry><neurological disease><neuromodulation><neuromodulatory><neuroregulation><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-human primate><non-invasive brain stimulation><nonhuman primate><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><postmortem><pre-clinical efficacy><pre-clinical safety><preclinical efficacy><preclinical safety><pressure><primary degenerative dementia><programs><psychiatric illness><psychological disorder><schizophrenic><senile dementia of the Alzheimer type><striatal><synaptic circuit><synaptic circuitry><tissue oxygen saturation><tissue oxygenation><tool><touch panel><touch screen><touch screen panel><touchscreen><touchscreen panel><working memory><γ-Aminobutyric Acid>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Elisa E. Konofagou

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$736,314

FY 2026

Project Title

Focused ultrasound for memory disorders

Grant Number:

5R01MH133020-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary/Abstract Working memory (WM) is a core component of executive function. WM is impaired in conditions that affect roughly 20M people in the US alone, including Alzheimer’s disease (5.8M), Parkinson’s disease (1.2M), schizophrenia (1.5M), attention deficit hyperactivity disorder (6.1M) and aut...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD dementia><AD patients><AD/HD><ADHD><ASD><Abnormal Movements><Address><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease patient><Alzheimer's patient><Alzheimers Dementia><Amentia><Aminalon><Aminalone><Area><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Autopsy><Behavioral><Blood - brain barrier anatomy><Blood-Brain Barrier><Brain><Brain Nervous System><Brain region><Cerebellar Dysmetria><Chemicals><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive Retention Disorders><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Computer software><Contralateral><Corpus Striatum><Corpus striatum structure><Data><Decision Making><Deep Brain Stimulation><Dementia><Disturbance in cognition><Dorsal><Dose><Drug Delivery><Drug Delivery Systems><Drug Targeting><Drugs><Dyskinesias><Dyskinetic syndrome><Dysmetria><E-stim><Early Infantile Autism><Electric Stimulation><Encephalon><Focused Ultrasound><Focused Ultrasound Ablation><Focused Ultrasound Therapy><Focused Ultrasound Treatment><Frequencies><Functional MRI><Functional Magnetic Resonance Imaging><GABA><Goals><Hemato-Encephalic Barrier><High Power Focused Ultrasound><High-intensity focused ultrasound><Histology><Human><Hydrogen Oxide><Immediate Memory><Impaired cognition><Impairment><Infantile Autism><Intravenous><Ipsilateral><Kanner's Syndrome><Length><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Maps><Measures><Mediating><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Memory><Memory Deficit><Memory Disorders><Memory impairment><Mental disorders><Mental health disorders><Methods><Microbubbles><Modern Man><Motor><Motor Cortex><Movement><NMR Imaging><NMR Tomography><Nerve Transmitter Substances><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Neurotransmitters><Nuclear Magnetic Resonance Imaging><Nucleus Caudatus><Paralysis Agitans><Parkinson><Parkinson Disease><Patients><Performance><Perfusion><Persons><Pharmaceutical Preparations><Physiologic><Physiologic pulse><Physiological><Physiology><Predisposition><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prefrontal Cortex><Primary Parkinsonism><Primary Senile Degenerative Dementia><Psychiatric Disease><Psychiatric Disorder><Pulse><Research><Safety><Schizophrenia><Schizophrenic Disorders><Short-Term Memory><Software><Speed><Striate Body><Striatum><Structure><Susceptibility><Testing><Thermometry><Time><Tremor><Water><Work><Zeugmatography><arterial spin labeling><arterial spin tagging><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><awake><bloodbrain barrier><body movement><brain behavior><caudate nucleus><cognitive defects><cognitive dysfunction><cognitive loss><dementia praecox><drug/agent><effectiveness testing><electrostimulation><executive control><executive function><experience><experiment><experimental research><experimental study><experiments><fMRI><gamma-Aminobutyric Acid><human data><improved><intravenous injection><member><memory dysfunction><mental illness><necropsy><neural circuit><neural circuitry><neural control><neural regulation><neurocircuitry><neurological disease><neuromodulation><neuromodulatory><neuroregulation><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-human primate><non-invasive brain stimulation><nonhuman primate><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><postmortem><pre-clinical efficacy><pre-clinical safety><preclinical efficacy><preclinical safety><pressure><primary degenerative dementia><programs><psychiatric illness><psychological disorder><schizophrenic><senile dementia of the Alzheimer type><striatal><synaptic circuit><synaptic circuitry><tissue oxygen saturation><tissue oxygenation><tool><touch panel><touch screen><touch screen panel><touchscreen><touchscreen panel><working memory><γ-Aminobutyric Acid>

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Xinyu Zhao

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$731,975

FY 2026

Project Title

Interrogate FMRP functions in primate brain development

Grant Number:

5R01MH136152-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Fragile X Syndrome (FXS), caused by deficiency of RNA binding protein Fragile X Messenger Ribonucleoprotein 1 protein (FMRP), encoded by X-linked FMR1 gene, is the most common heritable cause of intellectual disability and a top contributor to autism spectrum disorders (ASD). The mechanisms underlyi...

Research Terms

<21+ years old><ASD><Adult><Adult Human><Affect><Age><Autism><Autistic Disorder><Behavioral><Binding Proteins><Brain><Brain Nervous System><CLIP-Seq><Cell Body><Cells><Clinical Trials><Complex><Creativeness><DNA mutation><Data><Decision Making><Development><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Escalante syndrome><Essential Genes><Exhibits><Fragile X><Fragile X Syndrome><Gene Expression><Genes><Genetic Change><Genetic defect><Genetic mutation><Goals><HITS-CLIP><Heritability><High-throughput sequencing of CLIP cDNA library><Human><Immediate Memory><Impairment><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intelligence><Kanner's Syndrome><Knowledge><Language><Ligand Binding Protein><Ligand Binding Protein Gene><Link><M mulatta><M. mulatta><Macaca><Macaca mulatta><Macaca rhesus><Macaque><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Messenger RNA><Metabolic><Methods><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Molecular><Morphology><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Differentiation><Neurons><Neurophysiology / Electrophysiology><Pathogenesis><Physiologic><Physiological><Prefrontal Cortex><Primates><Primates Mammals><Protein Binding><Protein Deficiency><Proteins><Publications><RNA-Binding Proteins><Regulation><Renpenning syndrome 2><Resolution><Rhesus Macaque><Rhesus Monkey><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><Sampling><Scientific Publication><Short-Term Memory><Slice><Testing><Work><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><adulthood><ages><autism spectral disorder><autism spectrum disorder><autism-fragile X (AFRAX) syndrome><autistic spectrum disorder><bound protein><creativity><crosslinking and immunoprecipitation sequencing><deficiency of protein><developmental><differentiation of pluripotent stem cells><electrophysiological><fetal><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><gene signatures><genetic signature><genome mutation><human derived pluripotent stem cell><human pluripotent stem cell><intellectual and developmental disability><knock-down><knockdown><limited intellectual functioning><mRNA><mRNP><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><messenger ribonucleoprotein><mitochondrial><neurodevelopmental disease><neuronal><patch clamp><patch sequencing><patch-seq><patchseq><pluripotent stem cell differentiation><post-natal development><postnatal><postnatal development><prenatal><primary end point><primary endpoint><protein function><resolutions><social role><synapse formation><synaptogenesis><therapeutic agent development><therapeutic development><tissue resource><transcriptomics><unborn><working memory>

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Julio Licinio

UPSTATE MEDICAL UNIVERSITY, SYRACUSE, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$728,682

FY 2026

Project Title

Dissecting the roles of an epigenetic regulator of genes involved in synaptic plasticity and social cognition.

Grant Number:

5R01MH127423-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT This proposal represents a highly innovative line of research focused on understanding the mechanism/s by which PHF21B (plant homeodomain finger protein 21B) deficiency impairs social memory. Social impairments, which may be present in multiple psychiatric disorders, are cha...

Research Terms

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MA-LI WONG

UPSTATE MEDICAL UNIVERSITY, SYRACUSE, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$728,682

FY 2026

Project Title

Dissecting the roles of an epigenetic regulator of genes involved in synaptic plasticity and social cognition.

Grant Number:

5R01MH127423-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT This proposal represents a highly innovative line of research focused on understanding the mechanism/s by which PHF21B (plant homeodomain finger protein 21B) deficiency impairs social memory. Social impairments, which may be present in multiple psychiatric disorders, are cha...

Research Terms

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LISA STOWERS

SCRIPPS RESEARCH INSTITUTE, THE, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$723,194

FY 2026

Project Title

Decoding vomeronasal activity through awake, behaving AOB imaging.

Grant Number:

5R01DC021238-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary: The sense of smell in the mouse largely occurs through the main olfactory system (MOS) which has the amazing ability to detect trace amounts of an infinite variety of volatile organic ligands. With this sensory power why does the mouse, and most terrestrial vertebrates, also have a vomerona...

Research Terms

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Adriana Di Martino

CHILD MIND INSTITUTE, INC., NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$709,383

FY 2026

Project Title

A mega-analysis framework for delineating autism neurosubtypes

Grant Number:

5R01MH133334-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT This application proposes to lay the groundwork for precision medicine approaches to autism spectrum disorder (ASD) by identifying reproducible clinically relevant brain-connectome-based subtypes. The proposal addresses the clinical and biological heterogeneity of ASD by focusing on the int...

Research Terms

<0-11 years old><18 year old><18 years of age><ASD><Address><Age><Aggregated Data><Algorithms><Attention><Autism><Autistic Disorder><Bayesian Method><Bayesian Methodology><Bayesian Modeling><Bayesian Statistical Method><Bayesian adaptive designs><Bayesian adaptive models><Bayesian approaches><Bayesian belief network><Bayesian belief updating model><Bayesian classification method><Bayesian classification procedure><Bayesian framework><Bayesian hierarchical model><Bayesian network model><Bayesian nonparametric models><Bayesian posterior distribution><Bayesian spatial data model><Bayesian spatial image models><Bayesian spatial models><Bayesian statistical models><Bayesian tracking algorithms><Biological><Brain><Brain Nervous System><Brain imaging><Caring><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Data><Clinical Protocols><Collection><Communities><Data><Data Aggregation><Data Bases><Data Collection><Databases><Diagnosis><Diagnostic Specificity><Dimensions><Early Infantile Autism><Encephalon><Functional MRI><Functional Magnetic Resonance Imaging><Goals><Grain><Heterogeneity><Hybrids><Image><Individual><Infantile Autism><Kanner's Syndrome><Knowledge><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measurement><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methodology><Methods><Modeling><NMR Imaging><NMR Tomography><Nature><Neurosciences><Nuclear Magnetic Resonance Imaging><Pattern><Phenotype><Reproducibility><Research><Research Resources><Resources><Rest><Sample Size><Sampling><Site><Source><Structure><Subgroup><Symptoms><Syndrome><System><Systems Analyses><Systems Analysis><Testing><Time><Variant><Variation><Work><Zeugmatography><age 18><age 18 years><ages><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><biologic><biological heterogeneity><biological research><boys><brain abnormalities><brain behavior><brain visualization><clinical heterogeneity><clinical phenotype><clinical relevance><clinically relevant><combat><connectome><data base><data exchange><data harmonization><data resource><data transfer><data transmission><eighteen year old><eighteen years of age><fMRI><girls><harmonized data><imaging><improved><indexing><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><kids><large data sets><large datasets><mosaic><neural><neural imaging><neuro-imaging><neuroimaging><neurological imaging><neurophysiological><neurophysiology><novel><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><phenotypic data><precision medicine><precision-based medicine><quality assurance><repetitive behavior><response><sex><social communication><social structural><social structure><socio-structural><sociostructural><theories><youngster>

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Rebecca Ann Muhle

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$705,897

FY 2026

Project Title

IMPACT OF LOSS OF THE AUTISM RISK GENE CHD8 ON EXPRESSION, EPIGENETICS AND CELLULAR FUNCTIONING OF THE DOPAMINERGIC SYSTEM

Grant Number:

5R01MH130372-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/17/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Dr. Rebecca Muhle is a practicing child psychiatrist and an Early Stage Investigator with a strong track record of developing molecular genetic tools to elucidate the mechanism of neurodevelopmental disorders. Her long- term goal is to identify cell types, circuits and regulatory ne...

Research Terms

<0-11 years old><ASD><ATAC sequencing><ATAC-seq><ATACseq><Affect><Animal Model><Animal Models and Related Studies><Assay for Transposase-Accessible Chromatin using sequencing><Atlases><Attenuated><Autism><Autistic Disorder><Basal Ganglia><Basal Nuclei><Behavior><Behavior-Related Disorder><Behavior-Related Problem><Behavioral><Binding><Biological><Biology><Biotinylation><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular biology><ChIP Sequencing><ChIP assay><ChIP-seq><ChIPseq><Child><Child Youth><Children (0-21)><Chromatin><Chromosomal, Gene, or Protein Abnormality><Chronic><Collaborations><Complex><Corpus Striatum><Corpus striatum structure><Cre driver><Critical Paths><Critical Pathways><Cytogenetic or Molecular Genetic Abnormality><DA Neuron><DAT dopamine transporter><DNA><DNA Helicases><DNA Unwinding Proteins><DNA mutation><DNA unwinding enzyme><DNA-Binding Proteins><Data><Data Set><Defect><Deoxyribonucleic Acid><Development><Doctor of Medicine><Doctor of Philosophy><Dopamine><Dopamine Agonists><Dopamine Receptor><Dopamine Receptor Agonists><Dopamine neuron><Dopaminergic Agonists><Drugs><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Encephalon Diseases><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Fellowship><Female><Fiber><Foundations><Funding><Future><Gene Expression><Gene Transcription><Genes><Genetic Abnormality><Genetic Change><Genetic Risk><Genetic Transcription><Genetic defect><Genetic mutation><Genomic Segment><Genomics><Goals><Human><Hydroxytyramine><Infantile Autism><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Investigation><Investigators><Kanner's Syndrome><Knowledge><Label><Lifestyle-Related Disorder><Lifestyle-Related Problem><Lifestyle-related condition><LoxP-flanked allele><M.D.><Maps><Medication><Mentorship><Mesencephalon><Mice><Mice Mammals><Microdialysis><Mid-brain><Midbrain><Midbrain structure><Modeling><Modern Man><Molecular><Molecular Abnormality><Molecular Genetics><Molecular Interaction><Morbidity><Murine><Mus><Mutation><NIMH><National Institute of Mental Health><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Nuclear><Nuclear RNA><Outcome><Pathway interactions><Ph.D.><PhD><Pharmaceutical Preparations><Photometry><Play><Population><Psychiatrist><Public Health><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Regulation><Research><Research Personnel><Researchers><Resolution><Risk><Risk Factors><Risk-associated variant><Role><Societies><Specific qualifier value><Specified><Stimulus><Striate Body><Striatum><Structure><Subcellular Process><Synapses><Synaptic><System><Transcription><Transgenes><Transmission><Universities><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><attenuate><attenuates><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><axon signaling><axon-glial signaling><axonal signaling><behavioral impairment><biologic><cell biology><cell type><chromatin immunoprecipitation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chromatin remodeling><developmental><dopamine system><dopamine transporter><dopaminergic neuron><drug/agent><electrophysiological><epigenetic profiling><epigenetically><extracellular><floxed><floxed allele><functional genomics><genome mutation><genome segment><genomic region><glia signaling><glial signaling><helicase><impaired behavior><in vivo><insight><kids><male><model of animal><molecular aberrations><mortality><mouse model><multiomics><multiple omics><murine model><nerve signaling><neural signaling><neurobehavioral disorder><neurobiological><neurodevelopmental disease><neuronal><neuronal signaling><neurotransmission><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><optogenetics><panomics><pathway><postsynaptic><presynaptic><promoter><promotor><repetitive behavior><resolutions><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sex><social><social role><stereotypy><striatal><synapse><tool><trait><transcriptome profiling><transcriptome sequencing><transcriptomic profiling><transcriptomic sequencing><transcriptomics><transgene><translational study><transmission process><youngster><♀><♂>

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Jessica Tollkuhn

COLD SPRING HARBOR LABORATORY, COLD SPRING HARBOR, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$701,200

FY 2026

Project Title

Dissecting basal ganglia circuits underlying motivated behaviors

Grant Number:

5R01MH108924-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/28/2015

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Dissecting basal ganglia circuits underlying motivated behaviors Project Summary The basal ganglia, in particular the dorsal striatum, play essential roles in motor control, motivational regulation and reinforcement learning. On the other hand, striatal dysfunctions have been implicated in a number...

Research Terms

<2-photon><ASD><Address><Adenosine Cyclic Monophosphate-Dependent Protein Kinases><Affect><Affective Disorders><Anatomic Sites><Anatomic structures><Anatomy><Anxiety Disorders><Autism><Autistic Disorder><Basal Ganglia><Basal Nuclei><Behavior><Behavioral><Brain><Brain Nervous System><Calcium><Cell Communication and Signaling><Cell Signaling><Chemical Dependence><Clinical><Code><Coding System><Corpus Striatum><Corpus striatum structure><Cyclic AMP-Dependent Protein Kinases><DA Neuron><Disease><Disorder><Dopamine neuron><Dorsal><Drug Addiction><Drug Dependence><Drug Dependency><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Evaluation><FLIM imaging><Family><Foundations><Functional disorder><Ganglia><Genetic><Globus Pallidus><Goals><Habenula><Health><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><Infantile Autism><Intracellular Communication and Signaling><KI mice><Kanner's Syndrome><Knock-in Mouse><Label><Learned Helplessness><Learning><Life Stress><Maps><Mediating><Mental Depression><Mental disorders><Mental health disorders><Mesencephalon><Mice><Mice Mammals><Mid-brain><Midbrain><Midbrain structure><Monitor><Mood Disorders><Moods><Motivation><Motor><Movement><Murine><Mus><Negative Reinforcements><Negative Valence><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Ganglion><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Neurophysiology / Electrophysiology><Obsessive-Compulsive Disorder><Obsessive-Compulsive Neurosis><Opiate Receptors><Opioid Receptor><PKA><Paralysis Agitans><Parkinson><Parkinson Disease><Pathway interactions><Physiopathology><Play><Population><Population Control><Positive Reinforcements><Positive Valence><Predisposition><Primary Parkinsonism><Procedures><Property><Protein Kinase A><Psychiatric Disease><Psychiatric Disorder><Psychological reinforcement><Publishing><Punishment><Regulation><Reinforcement><Research><Rewards><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Stimulus><Stress><Stressful Event><Striate Body><Striatum><Susceptibility><Techniques><Testing><Zinc Finger Domain><Zinc Finger Motifs><Zinc Fingers><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><avoidance behavior><biological signal transduction><body movement><cAMP-Dependent Protein Kinases><conditioned helplessness><depression><dopaminergic neuron><electrophysiological><fluorescence life-time imaging><fluorescence life-time imaging microscopy><fluorescence lifetime imaging><fluorescence lifetime imaging microscopy><imaging in vivo><in vivo><in vivo imaging><knockin mice><maladaptive behavior><mental illness><motivated behavior><motor control><mouse genetics><multiplexed imaging><neurochemical><neurochemistry><neurological disease><neuronal><novel><optogenetics><pallidum><pathophysiology><pathway><prodynorphin><programs><psychiatric illness><psychological disorder><resilience><resilient><social defeat><social role><stressful experience><stressful life event><stressful life experience><striatal><striosome><synapse function><synaptic function><tool><two-photon>

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Zheng Wang

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$681,095

FY 2026

Project Title

Quantification of the neurocognitive, brain, and blood markers of dementia in middle-aged autistic adults

Grant Number:

5R01AG086493-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT/ SUMMARY This R01 study will apply neurocognitive, brain, and plasma biomarkers to quantify prodromal signs of dementia in autistic adults ages 40-65. Autism spectrum disorder (ASD) is a lifelong condition that continuously demands precision diagnosis, targeted treatment, and high-quality c...

Research Terms

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Ivy E Dick

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$680,243

FY 2026

Project Title

Dissecting the Role of Ca2+ Channel Dysfunction in the Pathogenesis of Neurodevelopmental Disorders

Grant Number:

5R01MH137160-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/14/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Neurodevelopmental disorders (NDD) consist of a varied group of neurological conditions including autism spectrum disorder (ASD). In most cases, the underlying cause of NDD is unknown, making it difficult to dissect the fundamental pathogenic mechanisms. Yet, genome-sequencing studies have identifie...

Research Terms

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ETHAN M GOLDBERG

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$674,970

FY 2026

Project Title

Interneuron axonopathy underlies circuit dysfunction in a mouse model of Dravet syndrome

Grant Number:

5R01NS110869-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2019

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Dravet syndrome (DS) is a severe neurodevelopmental disorder affecting 1 in 15,000 children and defined by treatment-resistant epilepsy, intellectual disability, features of autism spectrum disorder (ASD), and high rate of sudden unexplained death (SUDEP). DS is caused by variants in...

Research Terms

<0-11 years old><ASD><Action Potentials><Affect><Ammon Horn><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anatomic Sites><Anatomic structures><Anatomy><Area><Atlases><Autism><Autistic Disorder><Axon><Behavior><Behavioral><Biologic Models><Biological Models><Brain><Brain Nervous System><Brain Stem><Brain region><Brainstem><Cell Body><Cell Transplantation><Cells><Cerebral cortex><Cessation of life><Child><Child Youth><Children (0-21)><Chronic><Chronic Phase><Clinical genetics><Cognitive><Connector Neuron><Cornu Ammonis><DNA Therapy><DNA mutation><Data><Death><Development><Disease><Disorder><Dissociation><Distal><Dysfunction><Early Infantile Autism><Electron Microscopy><Electrophysiology><Electrophysiology (science)><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Experimental Models><Expression Signature><Failure><Family><Female><Frequencies><Functional disorder><Funding><Gene Expression Profile><Gene Transfer Clinical><Generations><Genes><Genetic Change><Genetic Intervention><Genetic defect><Genetic mutation><Genotype><Glia><Glial Cells><Goals><Grant><Hippocampus><Human><Hypothalamic structure><Hypothalamus><Immunoblotting><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><In Vitro><In vivo two-photon calcium imaging><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Ion Channel><Ionic Channels><Kanner's Syndrome><Knowledge><Kolliker's reticulum><Label><Lead><Link><Maps><Measures><Medical Genetics><Membrane><Membrane Channels><Mice><Mice Mammals><Model System><Modern Man><Molecular><Murine><Mus><Mutation><Myelin><Na element><Na(v)1.1><Nav1.1><Neocortex><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurological Development Disorder><Neurophysiology / Electrophysiology><Neurosciences><Non-neuronal cell><Nonneuronal cell><Outcome><PHM27><Palliative Care><Palliative Therapy><Palliative Treatment><Parvalbumins><Pathogenesis><Pathology><Patients><Pattern><Pb element><Performance><Physiologic><Physiological><Physiology><Physiopathology><Property><Proteins><Pyramidal Cells><RNA based therapeutics><RNA based therapy><RNA therapy><Recovery><Research><Resistance><Role><SCN1A protein><Seizure Disorder><Seizures><Single-Nucleus Sequencing><Site><Slice><Sodium><Synapses><Synaptic><Testing><Thalamic structure><Thalamus><Time><Transcript><Upregulation><Variant><Variation><Vasoactive Intestinal Peptide><Vasoactive Intestinal Polypeptide><Vasointestinal Peptide><Western Blotting><Western Immunoblotting><Wild Type Mouse><Work><amygdaloid nuclear complex><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><axonopathy><behavior test><behavioral test><biophysical characteristics><biophysical characterization><biophysical measurement><biophysical parameters><biophysical properties><cell type><cellular transplant><co-morbid><co-morbidity><comfort care><comorbidity><design><designing><developmental><dravet syndrome><electrophysiological><epilepsia><epileptogenic><experiment><experimental research><experimental study><experiments><gene expression pattern><gene expression signature><gene repair therapy><gene therapy><gene-based therapy><genetic diagnosis><genetic disorder diagnosis><genetic therapy><genome mutation><genomic therapy><heavy metal Pb><heavy metal lead><hippocampal><homotypical cortex><hypothalamic><in vivo><in vivo calcium imaging><innovate><innovation><innovative><intellectual and developmental disability><isocortex><kids><knowledge translation><limited intellectual functioning><male><membrane structure><mouse model><murine model><myelination><neopallium><nerve cement><neural cell body><neurodevelopmental disease><neuronal cell body><neuronal excitability><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><open source><optogenetics><palliative><palliative intervention><pathophysiology><postnatal><pre-clinical><preclinical><programs><protein blotting><reconstruction><resistant><response><sNuc-Seq><severe myoclonic epilepsy of infancy><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><soma><synapse><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><thalamic><therapeutic RNA><transcriptional profile><transcriptional signature><transcriptome profiling><transcriptomic profiling><transcriptomics><voltage><voltage clamp><wildtype mouse><youngster><♀><♂>

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Kevin J Bender

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$672,761

FY 2026

Project Title

CRISPRa-based rescue of sensorimotor deficits in the Scn2a+/- mouse model of autism spectrum disorder

Grant Number:

5R01MH136475-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Title: CRISPRa-based rescue of sensorimotor deficits in the Scn2a+/- mouse model of autism spectrum disorder Project Summary: Heterozygous loss-of-function mutations in the sodium channel gene SCN2A are strongly associated with autism spectrum disorder. SCN2A encodes the neuronal sodium channel NaV1...

Research Terms

<12-20 years old><21+ years old><ASD><Action Potentials><Acute><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Alleles><Allelic Loss><Allelomorphs><Animals><Area><Autism><Autistic Disorder><Axon><Behavior><Behavioral><Biological Markers><Brain><Brain Nervous System><Brain region><CRISPR activation><CRISPR activator><CRISPR based activation><CRISPR gene activation><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-dCAS9 Activator><CRISPR-mediated transcriptional activation><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/dCas9 activation><CRISPR/dCas9-based transcriptional activation><CRISPRa><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cerebellum><Code><Coding System><Cytoplasmic Granules><DNA Therapy><Data><Dendrites><Development><Disease><Disorder><Dysfunction><EEG><Early Infantile Autism><Electrocorticogram><Electroencephalogram><Electroencephalography><Encephalon><Enhancers><Exhibits><Frequencies><Functional disorder><Gene Expression><Gene Transfer Clinical><Genes><Genetic><Genetic Intervention><Goals><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Impairment><Infantile Autism><Intervention><Kanner's Syndrome><Laboratories><Learning><Link><Loss of Heterozygosity><Maps><Membrane><Methods><Mice><Mice Mammals><Modeling><Modern Man><Morbid Obesity><Motor><Murine><Mus><Nav1.2><Neocortex><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Phenotype><Physiologic><Physiological><Physiology><Physiopathology><Population><Position><Positioning Attribute><Prefrontal Cortex><Preparation><Proteins><Purkinje Cells><Purkinje's Corpuscles><Pyramidal Cells><Reagent><Reflex><Reflex action><Risk-associated variant><SCN2A protein><Sensory><Severe obesity><Sodium Channel><Sodium Ion Channels><Somatosensory Cortex><Space Perception><Spatial Discrimination><Specificity><Subcellular Process><Synapses><Synaptic><Synaptic plasticity><System><Testing><Therapeutic><Therapeutic Intervention><Touch><Touch sensation><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcriptional Activator/Coactivator><Transmission><Upregulation><Vibrissae><Visual><Whiskers><Work><activating CRISPR technology><adolescence (12-20)><adulthood><assess effectiveness><autism model><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior phenotype><behavioral impairment><behavioral phenotyping><bio-markers><biologic marker><biomarker><cerebellar Purkinje cell><critical developmental period><critical period><determine effectiveness><determine efficacy><developmental><effective intervention><effectiveness assessment><effectiveness evaluation><effectiveness testing><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electrocorticography><evaluate effectiveness><evaluate efficacy><examine effectiveness><examine efficacy><experiment><experimental research><experimental study><experiments><extreme obesity><functional genomics><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><granule><granule cell><homotypical cortex><iPS><iPSC><iPSCs><impaired behavior><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intervention therapy><isocortex><juvenile><juvenile human><loss of function><loss of function mutation><membrane structure><model of autism spectrum disorder><mouse model><murine model><na(v)1.2><neocortical><neopallium><neural><neurodevelopmental disease><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oculovestibular reflex><pathophysiology><perceptual spatial orientation><postsynaptic><preparations><promoter><promotor><repetitive behavior><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sensory cortex><social communication impairment><somatosensory><somesthetic sensory cortex><spatial orientation><spatial perception><synapse><synapse function><synaptic function><tactile sensation><transmission process><vestibo-ocular reflexes><vestibulo-occular system><vestibulo-ocular reflex><vestibulo-oculomotor reflex><vestibuloocular reflexes><voltage>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Daniel Feldman

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$672,761

FY 2026

Project Title

CRISPRa-based rescue of sensorimotor deficits in the Scn2a+/- mouse model of autism spectrum disorder

Grant Number:

5R01MH136475-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Title: CRISPRa-based rescue of sensorimotor deficits in the Scn2a+/- mouse model of autism spectrum disorder Project Summary: Heterozygous loss-of-function mutations in the sodium channel gene SCN2A are strongly associated with autism spectrum disorder. SCN2A encodes the neuronal sodium channel NaV1...

Research Terms

<12-20 years old><21+ years old><ASD><Action Potentials><Acute><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Alleles><Allelic Loss><Allelomorphs><Animals><Area><Autism><Autistic Disorder><Axon><Behavior><Behavioral><Biological Markers><Brain><Brain Nervous System><Brain region><CRISPR activation><CRISPR activator><CRISPR based activation><CRISPR gene activation><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-dCAS9 Activator><CRISPR-mediated transcriptional activation><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/dCas9 activation><CRISPR/dCas9-based transcriptional activation><CRISPRa><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cerebellum><Code><Coding System><Cytoplasmic Granules><DNA Therapy><Data><Dendrites><Development><Disease><Disorder><Dysfunction><EEG><Early Infantile Autism><Electrocorticogram><Electroencephalogram><Electroencephalography><Encephalon><Enhancers><Exhibits><Frequencies><Functional disorder><Gene Expression><Gene Transfer Clinical><Genes><Genetic><Genetic Intervention><Goals><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Impairment><Infantile Autism><Intervention><Kanner's Syndrome><Laboratories><Learning><Link><Loss of Heterozygosity><Maps><Membrane><Methods><Mice><Mice Mammals><Modeling><Modern Man><Morbid Obesity><Motor><Murine><Mus><Nav1.2><Neocortex><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Phenotype><Physiologic><Physiological><Physiology><Physiopathology><Population><Position><Positioning Attribute><Prefrontal Cortex><Preparation><Proteins><Purkinje Cells><Purkinje's Corpuscles><Pyramidal Cells><Reagent><Reflex><Reflex action><Risk-associated variant><SCN2A protein><Sensory><Severe obesity><Sodium Channel><Sodium Ion Channels><Somatosensory Cortex><Space Perception><Spatial Discrimination><Specificity><Subcellular Process><Synapses><Synaptic><Synaptic plasticity><System><Testing><Therapeutic><Therapeutic Intervention><Touch><Touch sensation><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcriptional Activator/Coactivator><Transmission><Upregulation><Vibrissae><Visual><Whiskers><Work><activating CRISPR technology><adolescence (12-20)><adulthood><assess effectiveness><autism model><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior phenotype><behavioral impairment><behavioral phenotyping><bio-markers><biologic marker><biomarker><cerebellar Purkinje cell><critical developmental period><critical period><determine effectiveness><determine efficacy><developmental><effective intervention><effectiveness assessment><effectiveness evaluation><effectiveness testing><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electrocorticography><evaluate effectiveness><evaluate efficacy><examine effectiveness><examine efficacy><experiment><experimental research><experimental study><experiments><extreme obesity><functional genomics><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><granule><granule cell><homotypical cortex><iPS><iPSC><iPSCs><impaired behavior><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intervention therapy><isocortex><juvenile><juvenile human><loss of function><loss of function mutation><membrane structure><model of autism spectrum disorder><mouse model><murine model><na(v)1.2><neocortical><neopallium><neural><neurodevelopmental disease><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oculovestibular reflex><pathophysiology><perceptual spatial orientation><postsynaptic><preparations><promoter><promotor><repetitive behavior><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sensory cortex><social communication impairment><somatosensory><somesthetic sensory cortex><spatial orientation><spatial perception><synapse><synapse function><synaptic function><tactile sensation><transmission process><vestibo-ocular reflexes><vestibulo-occular system><vestibulo-ocular reflex><vestibulo-oculomotor reflex><vestibuloocular reflexes><voltage>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

GEORGE A SPIROU

UNIVERSITY OF SOUTH FLORIDA, TAMPA, FL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$650,451

FY 2026

Project Title

Development of the Calyx of Held

Grant Number:

5R01DC007695-14

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/13/2007

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary: A hallmark of developing neural systems is the guidance by spontaneous and experience-driven neural activity for strengthening of some synaptic inputs and pruning of others to define topography of mature neural circuits. We and others have established formation of the calyx of Held ...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

HENRIQUE Prado VON GERSDORFF

UNIVERSITY OF SOUTH FLORIDA, TAMPA, FL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$650,451

FY 2026

Project Title

Development of the Calyx of Held

Grant Number:

5R01DC007695-14

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/13/2007

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary: A hallmark of developing neural systems is the guidance by spontaneous and experience-driven neural activity for strengthening of some synaptic inputs and pruning of others to define topography of mature neural circuits. We and others have established formation of the calyx of Held ...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Samuel Matthew Young

UNIVERSITY OF SOUTH FLORIDA, TAMPA, FL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$650,451

FY 2026

Project Title

Development of the Calyx of Held

Grant Number:

5R01DC007695-14

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/13/2007

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary: A hallmark of developing neural systems is the guidance by spontaneous and experience-driven neural activity for strengthening of some synaptic inputs and pruning of others to define topography of mature neural circuits. We and others have established formation of the calyx of Held ...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Elizabeth Anne McCullagh

OKLAHOMA STATE UNIVERSITY STILLWATER, STILLWATER, OK

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$644,604

FY 2026

Project Title

Functional Consequences of Fragile X Syndrome on Myelination in the Auditory Brainstem

Grant Number:

1R01DC021733-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Myelination is a key component of neural transmission allowing for fast transfer of synaptic information. Disruption of myelination has been implicated in many disorders, including Fragile X Syndrome (FXS), the most common monogenic form of autism spectrum disorder (ASD). The auditor...

Research Terms

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ABRAHAM REICHENBERG

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$625,347

FY 2026

Project Title

The risk of Alzheimer's disease and related dementias among individuals with Autism Spectrum Disorder (AsDRD)

Grant Number:

1R01AG096298-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The rising prevalence of Alzheimer's disease and related dementias (ADRD) necessitates the early identification of subgroups at high risk of developing these diseases. Recent evidence suggests that individuals with neurodevelopmental disorders, particularly autism spectrum disorder (...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><AD risk><AD risk factor><AD/HD><ADHD><ADRD><ASD><ASD patient><Address><Adult><Adult Human><Affect><Age Years><Aging><Alzheimer risk factor><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Amentia><Attention deficit hyperactivity disorder><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular Diseases><Causality><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Clinical><Data><Data Set><Data Sources><Dementia><Development><Diabetes Mellitus><Diagnostic><Disease><Disorder><Early Diagnosis><Early Infantile Autism><Early identification><Epilepsy><Epileptic Seizures><Epileptics><Ethnic Origin><Ethnicity><Etiology><Event><Exhibits><Face><Family><Female><General Population><General Public><Generations><Genetic><Genetic Diversity><Genetic Variation><Genomics><Goals><Health><Hyperlipemia><Hyperlipidemia><Hypertension><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Israel><Kanner's Syndrome><Knowledge><Life Cycle><Life Cycle Stages><Link><Mediating><Medical><Memory Deficit><Memory impairment><Mental Depression><Methods><Modeling><Modification><NIH><National Institutes of Health><Neurodevelopmental Disorder><Neurological Development Disorder><Parents><Pathway interactions><Patient Care><Patient Care Delivery><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prevalence><Prevention><Public Health><QOL><Quality of life><Race><Races><Registries><Reporting><Reproducibility><Research><Research Resources><Resources><Risk><Risk Estimate><Sampling><Seizure Disorder><Socio-economic status><Socioeconomic Status><Subgroup><Sweden><Testing><Time><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><United States National Institutes of Health><Validation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><adulthood><age associated><age associated effects><age correlated><age dependent><age effect><age linked><age related><age related effects><age specific><aged><aging effect><aging process><alzheimer risk><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic patient><autistic people><autistic spectrum disorder><cardiovascular disorder><care for patients><care of patients><caring for patients><causation><co-morbid><co-morbidity><comorbidity><dementia risk><depression><develop therapy><developmental><diabetes><diagnostic approach><diagnostic strategy><disease causation><early detection><epilepsia><epileptogenic><evidence base><experience><faces><facial><genetic etiology><genetic mechanism of disease><high blood pressure><high risk><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><impact of age><improved><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><influence of age><intellectual and developmental disability><intervention development><life course><limited intellectual functioning><male><memory dysfunction><multiple data sources><neurodevelopmental disease><parent><pathway><patient with ASD><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><population based><prevent><preventing><programs><racial><racial background><racial origin><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><secondary analysis><sex><societal costs><socio-demographic factors><socio-economic position><sociodemographic factors><socioeconomic position><therapy development><treatment development><validations><♀><♂>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sven Sandin

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$625,347

FY 2026

Project Title

The risk of Alzheimer's disease and related dementias among individuals with Autism Spectrum Disorder (AsDRD)

Grant Number:

1R01AG096298-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The rising prevalence of Alzheimer's disease and related dementias (ADRD) necessitates the early identification of subgroups at high risk of developing these diseases. Recent evidence suggests that individuals with neurodevelopmental disorders, particularly autism spectrum disorder (...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><AD risk><AD risk factor><AD/HD><ADHD><ADRD><ASD><ASD patient><Address><Adult><Adult Human><Affect><Age Years><Aging><Alzheimer risk factor><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Amentia><Attention deficit hyperactivity disorder><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular Diseases><Causality><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Clinical><Data><Data Set><Data Sources><Dementia><Development><Diabetes Mellitus><Diagnostic><Disease><Disorder><Early Diagnosis><Early Infantile Autism><Early identification><Epilepsy><Epileptic Seizures><Epileptics><Ethnic Origin><Ethnicity><Etiology><Event><Exhibits><Face><Family><Female><General Population><General Public><Generations><Genetic><Genetic Diversity><Genetic Variation><Genomics><Goals><Health><Hyperlipemia><Hyperlipidemia><Hypertension><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Israel><Kanner's Syndrome><Knowledge><Life Cycle><Life Cycle Stages><Link><Mediating><Medical><Memory Deficit><Memory impairment><Mental Depression><Methods><Modeling><Modification><NIH><National Institutes of Health><Neurodevelopmental Disorder><Neurological Development Disorder><Parents><Pathway interactions><Patient Care><Patient Care Delivery><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prevalence><Prevention><Public Health><QOL><Quality of life><Race><Races><Registries><Reporting><Reproducibility><Research><Research Resources><Resources><Risk><Risk Estimate><Sampling><Seizure Disorder><Socio-economic status><Socioeconomic Status><Subgroup><Sweden><Testing><Time><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><United States National Institutes of Health><Validation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><adulthood><age associated><age associated effects><age correlated><age dependent><age effect><age linked><age related><age related effects><age specific><aged><aging effect><aging process><alzheimer risk><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic patient><autistic people><autistic spectrum disorder><cardiovascular disorder><care for patients><care of patients><caring for patients><causation><co-morbid><co-morbidity><comorbidity><dementia risk><depression><develop therapy><developmental><diabetes><diagnostic approach><diagnostic strategy><disease causation><early detection><epilepsia><epileptogenic><evidence base><experience><faces><facial><genetic etiology><genetic mechanism of disease><high blood pressure><high risk><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><impact of age><improved><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><influence of age><intellectual and developmental disability><intervention development><life course><limited intellectual functioning><male><memory dysfunction><multiple data sources><neurodevelopmental disease><parent><pathway><patient with ASD><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><population based><prevent><preventing><programs><racial><racial background><racial origin><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><secondary analysis><sex><societal costs><socio-demographic factors><socio-economic position><sociodemographic factors><socioeconomic position><therapy development><treatment development><validations><♀><♂>

View Full Project Details on NIH Reporter

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Michal Schnaider Beeri

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$625,347

FY 2026

Project Title

The risk of Alzheimer's disease and related dementias among individuals with Autism Spectrum Disorder (AsDRD)

Grant Number:

1R01AG096298-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The rising prevalence of Alzheimer's disease and related dementias (ADRD) necessitates the early identification of subgroups at high risk of developing these diseases. Recent evidence suggests that individuals with neurodevelopmental disorders, particularly autism spectrum disorder (...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><AD risk><AD risk factor><AD/HD><ADHD><ADRD><ASD><ASD patient><Address><Adult><Adult Human><Affect><Age Years><Aging><Alzheimer risk factor><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Amentia><Attention deficit hyperactivity disorder><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular Diseases><Causality><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Clinical><Data><Data Set><Data Sources><Dementia><Development><Diabetes Mellitus><Diagnostic><Disease><Disorder><Early Diagnosis><Early Infantile Autism><Early identification><Epilepsy><Epileptic Seizures><Epileptics><Ethnic Origin><Ethnicity><Etiology><Event><Exhibits><Face><Family><Female><General Population><General Public><Generations><Genetic><Genetic Diversity><Genetic Variation><Genomics><Goals><Health><Hyperlipemia><Hyperlipidemia><Hypertension><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Israel><Kanner's Syndrome><Knowledge><Life Cycle><Life Cycle Stages><Link><Mediating><Medical><Memory Deficit><Memory impairment><Mental Depression><Methods><Modeling><Modification><NIH><National Institutes of Health><Neurodevelopmental Disorder><Neurological Development Disorder><Parents><Pathway interactions><Patient Care><Patient Care Delivery><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prevalence><Prevention><Public Health><QOL><Quality of life><Race><Races><Registries><Reporting><Reproducibility><Research><Research Resources><Resources><Risk><Risk Estimate><Sampling><Seizure Disorder><Socio-economic status><Socioeconomic Status><Subgroup><Sweden><Testing><Time><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><United States National Institutes of Health><Validation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><adulthood><age associated><age associated effects><age correlated><age dependent><age effect><age linked><age related><age related effects><age specific><aged><aging effect><aging process><alzheimer risk><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic patient><autistic people><autistic spectrum disorder><cardiovascular disorder><care for patients><care of patients><caring for patients><causation><co-morbid><co-morbidity><comorbidity><dementia risk><depression><develop therapy><developmental><diabetes><diagnostic approach><diagnostic strategy><disease causation><early detection><epilepsia><epileptogenic><evidence base><experience><faces><facial><genetic etiology><genetic mechanism of disease><high blood pressure><high risk><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><impact of age><improved><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><influence of age><intellectual and developmental disability><intervention development><life course><limited intellectual functioning><male><memory dysfunction><multiple data sources><neurodevelopmental disease><parent><pathway><patient with ASD><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><population based><prevent><preventing><programs><racial><racial background><racial origin><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><secondary analysis><sex><societal costs><socio-demographic factors><socio-economic position><sociodemographic factors><socioeconomic position><therapy development><treatment development><validations><♀><♂>

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JIAN FENG

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$618,417

FY 2026

Project Title

Epigenetics-Based Autism Treatment with Animal Models and Human Stem Cells

Grant Number:

5R01NS127728-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary This project aims to discover novel pharmacological intervention for core symptoms of autism, including social deficits and repetitive behaviors. One of the causal factors of autism is the loss of Shank3 gene, which encodes a scaffolding protein at glutamatergic synapses. We will use Shank3-...

Research Terms

<22q13 deletion syndrome><AOF2><ASD><ASD patient><Address><Animal Model><Animal Models and Related Studies><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Autopsy><Basal Transcription Factor><Basal transcription factor genes><Behavioral><Biochemical><Body Tissues><Causality><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Chromosomal, Gene, or Protein Abnormality><Corpus Striatum><Corpus striatum structure><Cytogenetic or Molecular Genetic Abnormality><DNA mutation><Defect><Drug Therapy><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Exhibits><Exons><Fibroblasts><Functional disorder><Gene Activation><Gene Down-Regulation><Gene Expression><Gene Expression Alteration><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Abnormality><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genetic study><Genomics><Glutamates><Goals><Heterozygote><Histones><Human><Human Genetics><Impairment><Induced pluripotent stem cell derived neurons><Infantile Autism><KDM1A><KDM1A gene><Kanner's Syndrome><L-Glutamate><L-Lysine><LSD1><Large-Scale Sequencing><Length><Link><Lysine><Lysine-Specific Demethylase 1><Lysine-Specific Demethylase 1A><Mediating><Methylation><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Abnormality><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neuronal Differentiation><Neurons><Neurophysiology / Electrophysiology><Pathogenicity><Patients><Pharmacological Treatment><Pharmacotherapy><Phelan-McDermid syndrome><Phenotype><Physiopathology><Play><Prefrontal Cortex><Proteins><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Research><Risk Factors><Risk-associated variant><Role><Scaffolding Protein><Social Interaction><Striate Body><Striatum><Synapses><Synaptic><Testing><Therapeutic><Therapeutic Effect><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription Repression><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Translating><Work><autism attributes><autism indicator><autism model><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic><autistic features><autistic patient><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><causation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><demethylation><disease causation><drug discovery><drug intervention><drug treatment><electrophysiological><epigenetically><gene repression><genome mutation><genome scale><genome-wide><genomewide><glutamatergic><heterozygosity><hiPSC><high risk><histone H3 methyltransferase><histone demethylase><histone methylase><histone methylation><histone methyltransferase><histone modification><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human progenitor><human progenitor cell derived><human stem cell-derived><human stem cells><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><innovate><innovation><innovative><interdisciplinary approach><knock-down><knockdown><loss of function mutation><model of animal><model of autism spectrum disorder><molecular aberrations><mouse model><multidisciplinary approach><murine model><necropsy><neurodevelopmental disease><neuronal><neuronal excitability><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathophysiology><patient with ASD><permissiveness><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><postmortem><progenitor cell differentiation><progenitor differentiation><repetitive behavior><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><side effect><social defects><social deficits><social disorders><social dysfunction><social role><stem and progenitor differentiation><stem cell approach><stem cell based approach><stem cell differentiation><stem cell method><stem cell methodology><stem cell procedure><stem cell technique><stem cell technology><striatal><synapse><synapse function><synaptic function><targeted agent><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcription factor><transcriptome sequencing><transcriptomic sequencing><treatment strategy>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Zhen Yan

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$618,417

FY 2026

Project Title

Epigenetics-Based Autism Treatment with Animal Models and Human Stem Cells

Grant Number:

5R01NS127728-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary This project aims to discover novel pharmacological intervention for core symptoms of autism, including social deficits and repetitive behaviors. One of the causal factors of autism is the loss of Shank3 gene, which encodes a scaffolding protein at glutamatergic synapses. We will use Shank3-...

Research Terms

<22q13 deletion syndrome><AOF2><ASD><ASD patient><Address><Animal Model><Animal Models and Related Studies><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Autopsy><Basal Transcription Factor><Basal transcription factor genes><Behavioral><Biochemical><Body Tissues><Causality><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Chromosomal, Gene, or Protein Abnormality><Corpus Striatum><Corpus striatum structure><Cytogenetic or Molecular Genetic Abnormality><DNA mutation><Defect><Drug Therapy><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Exhibits><Exons><Fibroblasts><Functional disorder><Gene Activation><Gene Down-Regulation><Gene Expression><Gene Expression Alteration><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Abnormality><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genetic study><Genomics><Glutamates><Goals><Heterozygote><Histones><Human><Human Genetics><Impairment><Induced pluripotent stem cell derived neurons><Infantile Autism><KDM1A><KDM1A gene><Kanner's Syndrome><L-Glutamate><L-Lysine><LSD1><Large-Scale Sequencing><Length><Link><Lysine><Lysine-Specific Demethylase 1><Lysine-Specific Demethylase 1A><Mediating><Methylation><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Abnormality><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neuronal Differentiation><Neurons><Neurophysiology / Electrophysiology><Pathogenicity><Patients><Pharmacological Treatment><Pharmacotherapy><Phelan-McDermid syndrome><Phenotype><Physiopathology><Play><Prefrontal Cortex><Proteins><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Research><Risk Factors><Risk-associated variant><Role><Scaffolding Protein><Social Interaction><Striate Body><Striatum><Synapses><Synaptic><Testing><Therapeutic><Therapeutic Effect><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription Repression><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Translating><Work><autism attributes><autism indicator><autism model><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic><autistic features><autistic patient><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><causation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><demethylation><disease causation><drug discovery><drug intervention><drug treatment><electrophysiological><epigenetically><gene repression><genome mutation><genome scale><genome-wide><genomewide><glutamatergic><heterozygosity><hiPSC><high risk><histone H3 methyltransferase><histone demethylase><histone methylase><histone methylation><histone methyltransferase><histone modification><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human progenitor><human progenitor cell derived><human stem cell-derived><human stem cells><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><innovate><innovation><innovative><interdisciplinary approach><knock-down><knockdown><loss of function mutation><model of animal><model of autism spectrum disorder><molecular aberrations><mouse model><multidisciplinary approach><murine model><necropsy><neurodevelopmental disease><neuronal><neuronal excitability><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathophysiology><patient with ASD><permissiveness><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><postmortem><progenitor cell differentiation><progenitor differentiation><repetitive behavior><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><side effect><social defects><social deficits><social disorders><social dysfunction><social role><stem and progenitor differentiation><stem cell approach><stem cell based approach><stem cell differentiation><stem cell method><stem cell methodology><stem cell procedure><stem cell technique><stem cell technology><striatal><synapse><synapse function><synaptic function><targeted agent><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcription factor><transcriptome sequencing><transcriptomic sequencing><treatment strategy>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Giacomo Vivanti

DREXEL UNIVERSITY, PHILADELPHIA, PA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$602,711

FY 2026

Project Title

Opt In - Implementation and Evaluation of an Early Intervention Program for Children Waiting to Receive an Autism Diagnosis

Grant Number:

5R01HD114761-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/20/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Parent-mediated early interventions for autism during toddlerhood are beneficial; however, intensive, autism- specific interventions typically do not begin until a child receives a diagnosis. As the median age of diagnosis in the US is 49 months, and services often do not begin for another 9 months ...

Research Terms

<0-11 years old><16 year old><16 years of age><ASD><Adaptive Behaviors><Address><Age><Agreement><Area><Autism><Autism Diagnosis><Autistic Disorder><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Brain><Brain Nervous System><Canada><Care Givers><Caregivers><Child><Child Development><Child Youth><Children (0-21)><Chronic><Clinical><Clinical Trials><Communities><Conditioning Therapy><Development><Diagnosis><Diagnostic><Early Infantile Autism><Early Intervention><Encephalon><Evaluation><Evidence based intervention><Family><Frustration><Goals><Infant and Child Development><Infantile Autism><Intervention><Intervention Strategies><Investigators><Kanner's Syndrome><Knowledge><Life><Literature><Mediating><Modeling><Outcome><Parents><Personal Satisfaction><Program Acceptability><Randomized><Randomized, Controlled Trials><Remote Consultation><Reporting><Research><Research Personnel><Research Resources><Researchers><Resources><Self Direction><Services><Time><Toddler><Training><Wait Time><Waiting Lists><acceptability and feasibility><adaptation behavior><adaptive behavior><age 16><age 16 years><ages><anxiety reduction><assess effectiveness><autism spectral disorder><autism spectrum disorder><autistic children><autistic spectrum disorder><behavior intervention><behavioral intervention><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical diagnosis><design><designing><determine effectiveness><developmental><effectiveness assessment><effectiveness evaluation><effectiveness testing><empowerment><evaluate effectiveness><evidence base><examine effectiveness><experience><implementation outcomes><improved><innovate><innovation><innovative><internet resource><intervention delivery><intervention design><intervention program><kids><on-line compendium><on-line resource><online compendium><online resource><parent><parenting education intervention><parenting education programs><parenting intervention><parenting program><parenting skill training><parenting training><programs><randomisation><randomization><randomized control trial><randomly assigned><response><sixteen year old><sixteen years of age><social communication><standardize measure><therapy design><treatment design><uptake><waitlist><web resource><web-based resource><well-being><wellbeing><youngster>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ashley Brooke de Marchena

DREXEL UNIVERSITY, PHILADELPHIA, PA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$594,637

FY 2026

Project Title

Creating a community-partnered measure of broad communication skills in autistic adults

Grant Number:

1R01DC022701-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Autistic adults universally face communication difficulties, yet no multi-dimensional measure of communication has been specifically validated in this population. The absence of such a measure is a barrier to advancing our understanding of communication strengths and challenges in autism – and how t...

Research Terms

<21+ years old><ASD><Acceleration><Address><Adult><Adult Human><Affect><Age><Attorneys><Autism><Autistic Disorder><Basic Research><Basic Science><Clinical Research><Clinical Study><Communication><Communication Disorders><Communication challenge><Communication difficulty><Communication impairment><Communicative Disorders><Communities><Consensus><Data><Development><Device or Instrument Development><Dimensions><Early Infantile Autism><Employment><Ensure><Ethics><Face><Gender><Goals><Guidelines><Health><Heterogeneity><Human Resources><Infantile Autism><Instruction><Intervention><Investigators><Kanner's Syndrome><Lawyers><Link><Literature><Lived experience><Lived experiences><Manpower><Measurement><Measures><Methods><NIDCD><National Institute on Deafness and Other Communication Disorders><Outcome><Outcome Measure><Outcomes Research><Participant><Patient Self-Report><Persons><Phase><Phenotype><Population><Process><Proxy><Public Health><Reporter><Reporting><Research><Research Personnel><Research Priority><Researchers><Sampling><Scientist><Self-Report><Series><Standardization><Target Populations><Testing><Validation><Variant><Variation><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><ages><autism spectral disorder><autism spectrum disorder><autistic><autistic adult><autistic individuals><autistic people><autistic spectrum disorder><cognitive interview><collaboration with communities><community based participatory approach><community based participatory design><community based participatory method><community based participatory process><community based participatory research><community collaboration><community led research><community participatory approach><community participatory design><community participatory method><community participatory model><community participatory research><community partnered participatory research><community partners><community-based collaboration><community-based partners><design><designing><developmental><device development><ethical><experience><faces><facial><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><innovate><innovation><innovative><instrument><instrument development><interest><language ability><language skills><life span><lifespan><literacy><marginalized group><marginalized individual><marginalized people><marginalized population><measurable outcome><novel><outcome measurement><outcome prediction><participatory action research><patient population><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><personnel><recruit><response><skills><sound><standard measure><validations>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

James Burkett

UNIVERSITY OF TOLEDO HEALTH SCI CAMPUS, TOLEDO, OH

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$592,124

FY 2026

Project Title

Developmental pyrethroid exposure in the prairie vole as a model of environmental risk for autism

Grant Number:

5R01ES036248-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The prevalence of autism and other neurodevelopmental disorders (NDDs) is at an all-time high, with 17% of children diagnosed with a developmental disability and 1 in 44 diagnosed with autism. Many of these disorders have few or no established biomarkers, few or no medical treatments...

Research Terms

<0-11 years old><ASD><Address><Adverse effects><Affect><Assay><Autism><Autistic Disorder><Behavior><Behavioral><Bioassay><Biological Assay><Biological Markers><Biological Rhythm><Blood Sample><Blood specimen><Brain><Brain Nervous System><Caring><Causality><Child><Child Development Disorders><Child Youth><Children (0-21)><Circadian Dysregulation><Circadian Rhythm Pathway><Circadian Rhythm Sleep Disorders><Cities><Complex><Corpus Striatum><Corpus striatum structure><Cricetinae><Cross-Over Designs><Crossover Design><Data><Data Set><Development><Developmental Delay><Developmental Delay Disorders><Developmental Disabilities><Diagnosis><Disease><Disorder><Disturbed Nyctohemeral Rhythm><Dose><Dysfunction><Early Infantile Autism><Ecological impact><Empathy><Encephalon><Environment><Environmental Factor><Environmental Impact><Environmental Risk Factor><Etiology><Exhibits><Exposure to><Functional disorder><Gene Transcription><General Population><General Public><Genes><Genetic Diversity><Genetic Transcription><Genetic Variation><Gestation><Goals><Hamsters><Hamsters Mammals><Hour><Human><Hyperactivity><Indigenous><Individual><Infantile Autism><Kanner's Syndrome><Kinases><Knowledge><Laboratories><Lactation><Learning><Link><Measures><Medical><Melatonin><Mice><Mice Mammals><Microtus><Midwest><Midwest U.S.><Midwest US><Midwestern United States><Modeling><Modern Man><Molecular><Molecular Target><Mothers><Movement><Multiomic Data><Murine><Mus><Nature><Neurodevelopmental Disorder><Neurological Development Disorder><Neurosciences><Outcome><Partner in relationship><Pathway interactions><Pattern><Pesticides><Phosphotransferase Gene><Phosphotransferases><Physiopathology><Population><Position><Positioning Attribute><Pregnancy><Pregnant Women><Prevalence><Prevention><Proteomics><Publishing><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Research><Retinol Metabolism><Retinol Metabolism Pathway><Risk><Risk Factors><Rodent><Rodentia><Rodents Mammals><Role><Sampling><Sleep-Wake Cycle Disorders><Sleep-Wake Schedule Disorders><Social Behavior><Social Network><Specific Child Development Disorders><Striate Body><Striatum><Technology><Testing><Therapeutic Intervention><Time><Transcription><Transphosphorylases><Tryptophan Metabolism><Tryptophan Metabolism Pathway><Vole><Wild Animals><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic people><autistic spectrum disorder><behavior outcome><behavior phenotype><behavior prediction><behavioral outcome><behavioral phenotyping><behavioral prediction><bio-markers><biologic marker><biomarker><body movement><causation><cell type><circadian><circadian abnormality><circadian disruption><circadian disturbance><circadian dysfunction><circadian impairment><co-exposures><co-morbid><co-morbidity><co-occurring exposure><cohort><combined exposure><comorbidity><complex exposure><concurrent exposure><decamethrin><deltamethrin><developmental><disease causation><environmental risk><epidemiology research study><epidemiology study><epidemiology survey><expectant mother><expectant women><expecting mother><expecting women><exposure mixture><field mouse><global gene expression><global transcription profile><individuals on the autism spectrum><individuals on the spectrum><individuals who are pregnant><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><intervention therapy><kids><lactating><lactational><mate><mixed exposure><multi-modality><multimodality><multiomics><multiple omic data><multiple omics><neurodevelopmental disease><offspring><panomics><pathophysiology><pathway><people on the autism spectrum><people who are pregnant><people with ASD><people with autism><people with autism spectrum disorder><pesticide exposure><prairie vole><pregnant females><pregnant mothers><pregnant people><pregnant populations><pyrethroid><repetitive behavior><response><scRNA sequencing><scRNA-seq><simultaneous exposures><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social><social role><sociobehavior><sociobehavioral><striatal><success><suprachiasmatic nucleus><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><those who are pregnant><transcriptome><transcriptome sequencing><transcriptomic sequencing><vocalization><women who are pregnant><youngster>

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JENNIFER M GROH

DUKE UNIVERSITY, DURHAM, NC

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$548,601

FY 2026

Project Title

Information Preservation in Neural Codes

Grant Number:

5R01NS129112-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Many things happen at once - there are always abundant stimuli to be perceived, items to be remembered, and courses of action to be planned. While considerable research has explored how our brains screen out the onslaught, we know less about how information about multiple stimuli is...

Research Terms

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Surya T Tokdar

DUKE UNIVERSITY, DURHAM, NC

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$548,601

FY 2026

Project Title

Information Preservation in Neural Codes

Grant Number:

5R01NS129112-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Many things happen at once - there are always abundant stimuli to be perceived, items to be remembered, and courses of action to be planned. While considerable research has explored how our brains screen out the onslaught, we know less about how information about multiple stimuli is...

Research Terms

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Yongsoo Kim

PENNSYLVANIA STATE UNIV HERSHEY MED CTR, HERSHEY, PA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$509,212

FY 2026

Project Title

Neuroanatomy and function of the ventral claustrum-dorsal endopiriform nucleus in mice

Grant Number:

5R01NS136371-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/24/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract Social behavior is regulated by a set of brain regions that integrate external stimuli with internal emotional states to generate context-appropriate behavioral responses. Dysfunctional social behavior has been implicated in many brain disorders including neurodevelopmental disorders (e.g.,...

Research Terms

<21+ years old><3-D><3-Dimensional><3D><5-HT Receptors><5-Hydroxytryptamine Receptors><ACh Receptors><AD dementia><ASD><Acetylcholine Receptors><Adult><Adult Human><Agonist><Algorithmic Analyses><Algorithmic Analysis><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Analyses of Algorithms><Analysis of Algorithms><Anatomic Sites><Anatomic structures><Anatomy><Anxiety><Area><Attention><Autism><Autistic Disorder><Behavioral><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Mapping><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cells><Characteristics><Cholinergic Receptors><Cholinoceptive Sites><Cholinoceptors><Claustral structure><Claustrum><Collaborations><Connector Neuron><Cues><Custom><Data><Degenerative Neurologic Disorders><Disinhibition><Dorsal><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Emotional><Emotions><Encephalon><Encephalon Diseases><Epilepsy><Epileptic Seizures><Epileptics><Epileptogenesis><Exploratory Behavior><Exposure to><Fluorescence Light Microscopy><Fluorescence Microscopy><Functional disorder><Future><Gene Expression><Genes><Impairment><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><Light><Maps><Medial><Mediating><Memory><Mental Depression><Methods><Mice><Mice Mammals><Molecular><Murine><Mus><Muscarinic Acetylcholine Receptor><Muscarinic Receptors><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural Transmission><Neural degenerative Disorders><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurobiology><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurodevelopmental Disorder><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Development Disorder><Neurological Disorders><Neuromodulator Receptors><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Nucleus><Ocytocin><Output><Oxytocin><Oxytocin Receptor><Pathologic><Pathway interactions><Pattern><Photoradiation><Physiopathology><Play><Prefrontal Cortex><Primary Senile Degenerative Dementia><Process><Rabies><Recombinant Oxytocin><Reporter><Research><Resolution><Rest><Role><Seizure Disorder><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Social Behavior><Social Interaction><Spatial Distribution><Stimulus><Synapses><Synaptic><Synaptic Transmission><System><Testing><Tissues><Viral><adulthood><antagonism><antagonist><approach behavior><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><awake><behavior response><behavioral response><biological signal transduction><cell type><common symptom><customs><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><depression><electrophysiological><epilepsia><epileptogenic><excitatory neuron><experiment><experimental research><experimental study><experiments><global gene expression><global transcription profile><in vivo><inhibitory neuron><lyssa><multisensory><neural><neural circuit><neural circuitry><neural control><neural regulation><neurobiological><neurobiological mechanism><neurocircuitry><neurodegenerative illness><neurodevelopmental disease><neurological disease><neuromodulation><neuromodulatory><neuronal><neuroregulation><novel><pathophysiology><pathway><primary degenerative dementia><receptor expression><resolutions><senile dementia of the Alzheimer type><serotonin receptor><social><social cognition><social influence><social role><sociobehavior><sociobehavioral><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><synapse><synaptic circuit><synaptic circuitry><three dimensional><tool><transcriptome>

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JAVIER F MEDINA

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$508,533

FY 2026

Project Title

STATE-DEPENDENT MODULATION OF CEREBELLAR FUNCTION

Grant Number:

1R01NS142192-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/11/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Proper cerebellar function is important for many aspects of mental health, as evidenced by the wide range of neurological and neuropsychiatric disorders that have been associated with impaired neural processing in the cerebellum, from ataxia and dystonia to schizophrenia, autism and ...

Research Terms

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Elizabeth Gould

PRINCETON UNIVERSITY, Princeton, NJ

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$507,090

FY 2026

Project Title

Perineuronal nets, hippocampal plasticity, and autism spectrum disorder.

Grant Number:

5R01MH118631-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Autism Spectrum Disorder (ASD) is a heterogeneous group of neurodevelopmental conditions, which often present with social recognition dysfunction. Phelan-McDermid syndrome and Fragile X syndrome, two monogenic causes of ASD, have social recognition deficits, such as difficulty recogn...

Research Terms

<21+ years old><22q13 deletion syndrome><ASD><Address><Adult><Adult Human><Affect><Ammon Horn><Autism><Autistic Disorder><Axon><Behavioral><Binding><Brain region><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cell-Extracellular Matrix><Collapsin><Collapsin-1><Collapsing Factor><Coloring Agents><Cornu Ammonis><Coupling><Cues><Data><Dendritic Spines><Detection><Development><Dyes><Dysfunction><ECM><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Emotions><Escalante syndrome><Euler-Gaddum Substance P><Exhibits><Extracellular Matrix><Face><Fragile X><Fragile X Syndrome><Functional disorder><Funding><Gene Expression><Genes><Genetic><Genetic Diseases><Genotype><Goals><Hippocampus><Human><Hypothalamic structure><Hypothalamus><Immediate-Early Genes><Impairment><Infantile Autism><Intervention><Intracellular Communication and Signaling><Kanner's Syndrome><Knock-out><Knockout><Knowledge><Label><Long-Term Potentiation><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Memory><Mice><Mice Mammals><Modern Man><Molecular Interaction><Murine><Mus><Mutate><NK-1 Receptors><NK1R><NKIR><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurokinin-1 Receptors><Neurons><Neuropeptides><Neurophysiology / Electrophysiology><Nucleus><Phelan-McDermid syndrome><Physiopathology><Play><Progress Reports><Renpenning syndrome 2><Resistance><Resolution><Retrieval><Role><SP-P Receptors><Sem D><Sema3A><Semaphorin D><Semaphorin-3A><Signal Transduction><Signal Transduction Systems><Signaling><Social Discrimination><Structure><Substance P><Substance P Receptor><Symptoms><Synapses><Synaptic><System><TAC1R><TACR1><TACR1 gene><Tachykinin><Tachykinin Receptor 1><Testing><Transgenic Mice><Viral><Voice><Wild Type Mouse><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><autism model><autism spectral disorder><autism spectrum disorder><autism-fragile X (AFRAX) syndrome><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><axon growth cone guidance><axon guidance><biological signal transduction><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><compare to control><comparison control><confocal imaging><dendrite spine><design><designing><developmental><electrophysiological><experiment><experimental research><experimental study><experiments><faces><facial><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><functional restoration><gene manipulation><genetic condition><genetic disorder><genetic manipulation><genetically manipulate><genetically perturb><hippocampal><hippocampal subregions><hypothalamic><improved><in vivo><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><innervation><interest><lipophilicity><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><model of autism spectrum disorder><mouse model><murine model><nerve supply><neural><neural imaging><neuro-imaging><neuroimaging><neurokinin 1><neurological imaging><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathophysiology><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><pharmacologic><post-natal period><postnatal period><pup><repetitive behavior><resistant><resolutions><restore function><restore functionality><restore lost function><social><social communication><social defects><social deficits><social disorders><social dysfunction><social role><substance use><substance using><synapse><synapse inhibition><synaptic inhibition><wildtype mouse>

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Luigi Puglielli

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$500,946

FY 2026

Project Title

Spastic paraplegia, neurodegeneration and autism: possible role for AT- 1/SLC33A1?

Grant Number:

2R01NS094154-11

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2015

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary We discovered that Nε-lysine acetylation occurs in the lumen of the endoplasmic reticulum (ER) in 2007. From that initial finding, we went on to discover the entire ER acetylation machinery (one membrane transporter, AT-1/SLC33A1, and two acetyltranferases, ATase1 and ATase2) and un...

Research Terms

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Anna Dunaevsky

UNIVERSITY OF NEBRASKA MEDICAL CENTER, OMAHA, NE

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$484,627

FY 2026

Project Title

Contribution of Glia to Sleep/Wake Disturbances in FXS

Grant Number:

5R01NS137084-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

2/28/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Sleep impairments are commonly reported in Fragile X syndrome (FXS) and autism spectrum disorders (ASD). Sleep impairments can have profound negative impact on brain development, cognition and general well-being however the underlying brain defects of sleep impairments in FXS are not well understood...

Research Terms

<0-11 years old><12-20 years old><2-photon microscopy><21+ years old><ASD><Adolescence><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Architecture><Astrocytes><Astrocytus><Astroglia><Autism><Autistic Disorder><Autoregulation><Behavior><Brain><Brain Nervous System><Cell Communication and Signaling><Cell Signaling><Child><Child Youth><Children (0-21)><Circadian Rhythms><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Data><Defect><Development><Disturbance in cognition><EEG><Early Infantile Autism><Electroencephalogram><Electroencephalography><Electrophysiology><Electrophysiology (science)><Encephalon><Engineering / Architecture><Escalante syndrome><Exhibits><FMR-1 Protein><FMR1 Protein><FMR1 gene><FMRP><FMRP protein><FRAXA><Fragile X><Fragile X Mental Retardation 1 Gene><Fragile X Mental Retardation Protein><Fragile X Syndrome><Genetic><Glia><Glial Cells><Goals><Hereditary><Homeostasis><Hyperactivity><Image><Impaired cognition><Impairment><Infantile Autism><Inherited><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intracellular Communication and Signaling><KO mice><Kanner's Syndrome><Knock-out Mice><Knockout Mice><Knowledge><Kolliker's reticulum><Levarterenol><Levonorepinephrine><Link><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Measures><Mediating><Mice><Mice Mammals><Molecular><Monitor><Murine><Mus><Mutant Strains Mice><NREM><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Neurophysiology / Electrophysiology><Non-neuronal cell><Nonneuronal cell><Noradrenaline><Norepinephrine><Null Mouse><Nyctohemeral Rhythm><Parents><Pattern><Personal Satisfaction><Phase><Phenotype><Physiological Homeostasis><Polysomnography><Renpenning syndrome 2><Reporting><Research><Role><Sensory impairment><Signal Transduction><Signal Transduction Systems><Signaling><Sleep><Sleep Architecture><Sleep Deprivation><Sleep Disorders><Sleep Monitoring><Sleep Stages><Sleep Wake Cycle><Sleep disturbances><Somnography><Structure><Synaptic plasticity><Telemetries><Telemetry><Testing><Twenty-Four Hour Rhythm><Wakefulness><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><aberrant sleep><adolescence (12-20)><adulthood><astrocytic glia><autism spectral disorder><autism spectrum disorder><autism-fragile X (AFRAX) syndrome><autistic spectrum disorder><awake><biological signal transduction><circadian process><circadian rhythmicity><clinical significance><clinically significant><cognitive dysfunction><cognitive loss><daily biorhythm><deficient sleep><developmental><disrupted sleep><disturbed sleep><electrophysiological><experiment><experimental research><experimental study><experiments><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X FMR1 protein><fragile X mental retardation 1><fragile X mental retardation-1 protein><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><genetic approach><genetic strategy><imaging><impaired sleep><in vivo><inadequate sleep><innovate><innovation><innovative><insufficient sleep><intellectual and developmental disability><irregular sleep><kids><limited intellectual functioning><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><model of animal><mouse model><mouse mutant><murine model><nerve cement><neuronal><non rapid eye movement><non-REM><non-rapid eye movement><nonREM><nonrapid eye movement><noradrenergic><novel><parent><rapid eye movement><restoration><sleep amount><sleep debt><sleep deficiency><sleep deficit><sleep diseases><sleep disruption><sleep duration><sleep dysfunction><sleep dysregulation><sleep episode><sleep illness><sleep insufficiency><sleep interval><sleep length><sleep loss><sleep measurement><sleep period><sleep polysomnography><sleep problem><sleep quantity><sleep time><sleep to wake transition><sleep to wakefulness transition><sleep wakefulness cycle><sleep/wake disruption><sleep/wake disturbance><sleep/wake transitions><social role><telemetric><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><two photon excitation microscopy><two photon microscopy><well-being><wellbeing><youngster>

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Ziv Williams

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$480,351

FY 2026

Project Title

A formal group theory-based model in primates for studying interactive social behavior and its dysfunction

Grant Number:

5R01MH131664-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

A formal group theory-based model in primates for studying interactive social behavior and its dysfunction Unlike most forms of solitary behavior that have been broadly studied through animal models, remarkably little is known about the single-neuronal or causal bases of interactive social behavior ...

Research Terms

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April R. Levin

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$461,954

FY 2026

Project Title

Paradoxical Sensory Responses: A Clue Towards Understanding Biotypes in Autism Spectrum Disorder and Other Neurodevelopmental Disorders

Grant Number:

5R01NS134948-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Autism Spectrum Disorder (ASD) and other neurodevelopmental conditions are currently classified according to behavioral criteria. This clinical diagnostic framework does not take into account underlying pathophysiology and is often insufficient to predict outcomes. The long-term goal is to ...

Research Terms

<0-11 years old><4 year old><4 years of age><AD/HD><ADHD><ASD><Acoustic Stimulation><Address><Affect><Anxiety><Attention><Attention deficit hyperactivity disorder><Auditory Stimulation><Autism><Autistic Disorder><Behavior><Behavioral><Biological Markers><Brain><Brain Nervous System><Care Givers><Caregivers><Categories><Cell Communication and Signaling><Cell Signaling><Child><Child Development><Child Youth><Children (0-21)><Classification><Complement><Complement Proteins><Computer software><Data><Development><Diagnosis><Disease><Disorder><Dysfunction><EEG><Early Infantile Autism><Electroencephalogram><Electroencephalography><Encephalon><Functional disorder><Goals><Individual><Infant and Child Development><Infantile Autism><Intracellular Communication and Signaling><Kanner's Syndrome><Measurable><Measurement><Measures><Methods><Nerve Cells><Nerve Unit><Neural Cell><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Neurophysiology - biologic function><Output><Physiopathology><Pilot Projects><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Public Health><Publishing><QOL><QOL improvement><Quality of life><Research><Risk><Sampling><Sensory><Sensory Process><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Software><Stimulus><Stratification><Subgroup><Symptoms><System><Systematics><Testing><Time><Work><age 4><age 4 years><age group><autism spectral disorder><autism spectrum disorder><autistic children><autistic individuals><autistic people><autistic spectrum disorder><behavior observation><behavior phenotype><behavior prediction><behavior response><behavioral observation><behavioral phenotyping><behavioral prediction><behavioral response><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker development><biotypes><brain based><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical diagnosis><clinical diagnostics><complementation><developmental><diagnostic development><endophenotype><four year old><four years of age><functional outcomes><habituation><improvements in QOL><improvements in quality of life><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><innovate><innovation><innovative><interpersonal competence><interpersonal competency><kids><medical diagnostic><neural><neural circuit><neural circuitry><neural function><neural mechanism><neurobiological><neurocircuitry><neurodevelopmental disease><neuromechanism><neuronal><novel><outcome prediction><pathophysiology><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><perceptual stimulus><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><physicochemical phenomena related to the senses><pilot study><quality of life improvement><response><sensory input><sensory stimulus><social competence><social competency><social skills><synaptic circuit><synaptic circuitry><tactile stimulation><time use><tool><youngster>

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Lucas Pinto

UNIVERSITY OF CHICAGO, CHICAGO, IL

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$461,189

FY 2026

Project Title

Microcircuit mechanisms behind the distributed cortical contributions to working memory

Grant Number:

7R01MH138285-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary / Abstract Working memory is the ability to hold and manipulate information in short-term memory in the absence of sensory input. Recent investigation into the neural underpinnings of this key cognitive ability has highlighted the existence of distributed working-memory representatio...

Research Terms

<2-photon><2-photon microscopy><ASD><Affect><Area><Autism><Autistic Disorder><Behavior><Behavioral><Calcium><Cell Body><Cells><Cerebrum><Clinical><Cognition><Cognitive><Complex><Connector Neuron><Cyclic Somatostatin><D Cells><Darkness><Data><Delayed Memory><Delta Cell><Dorsal><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Genetic><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Head><Human><Image><Immediate Memory><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Investigation><Kanner's Syndrome><Laboratories><Lateral><Logic><Macaca><Macaque><Maps><Measures><Mediating><Memory><Memory Deficit><Memory impairment><Methods><Mice><Mice Mammals><Modern Man><Motor Cortex><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Optics><PHM27><Parvalbumins><Pattern><Photons><Population Dynamics><Prefrontal Cortex><Primary visual cortex><Primates><Primates Mammals><Property><Recurrence><Recurrent><Reporting><Resolution><Role><Running><SRIH><SRIH-14><Schizophrenia><Schizophrenic Disorders><Sensory><Severities><Short-Term Memory><Somatostatin><Somatostatin Cells><Somatostatin Secreting Cell><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><Source><Stimulus><Striate Cortex><Striate area><Symptoms><Testing><Time><Vasoactive Intestinal Peptide><Vasoactive Intestinal Polypeptide><Vasointestinal Peptide><Viral><Work><animal imaging><area striata><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><cell type><cerebral><cognitive ability><cognitive process><computational neuroscience><dementia praecox><electrophysiological><excitatory neuron><extracellular><genetic approach><genetic strategy><growth hormone release inhibiting factor><imaging><improved><in vivo><inhibitory neuron><innovate><innovation><innovative><member><memory dysfunction><memory process><memory processing><natural aging><neural><neuronal><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><normal aging><normative aging><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><optical><optogenetics><recruit><resolutions><response><schizophrenic><sensory input><social role><tool><two photon excitation microscopy><two photon microscopy><two-photon><virtual reality><working memory>

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JENNIFER M GROH

DUKE UNIVERSITY, DURHAM, NC

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$437,179

FY 2026

Project Title

Mechanisms of Oculomotor Influences on Hearing

Grant Number:

5R01DC020363-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Hearing is an active process that works in concert with vision. How and where the active processes in hearing contribute to interactions with vision is presently unknown. One possibility is that these interactions occur at the earliest stages of the auditory pathway – within the ear....

Research Terms

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Ian C. Fiebelkorn

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$428,708

FY 2026

Project Title

The functional role of frontal and parietal feedback to visual cortex in selective visual attention

Grant Number:

5R01EY033726-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: Imagine Times Square in New York City: tall buildings, flashing lights, a swarm of people. This visual scene represents a potential overload of sensory information. To guide behavior, the brain uses a collection of filtering mechanisms that either boosts the processing of behavioral...

Research Terms

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Kendal Broadie

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$407,869

FY 2026

Project Title

Glial roles in experience-dependent critical period remodeling

Grant Number:

5R01NS132867-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Title: Glial roles in experience-dependent critical period remodeling Summary We propose glia actively prune brain circuits to optimize connectivity based on early-life sensory experience. Drosophila approaches are used to identify molecular mechanisms of activity-dependent glial pruning restricted ...

Research Terms

<21+ years old><ASD><Adenosine Cyclic Monophosphate-Dependent Protein Kinases><Adolescent><Adolescent Youth><Adult><Adult Human><Afferent Neurons><Animals><Assay><Autism><Autistic Disorder><Automobile Driving><Bioassay><Biological Assay><Biosensor><Brain><Brain Mapping><Brain Nervous System><CRISPR><CRISPR/Cas system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Cues><Cyclic AMP-Dependent Protein Kinases><DNA mutation><Dependence><Disease><Disorder><Dose><Drosophila><Drosophila genus><Early Infantile Autism><Encephalon><Escalante syndrome><Extracellular Signal-Regulated Kinase Gene><FMR-1 Protein><FMR1 Protein><FMR1 gene><FMRP><FMRP protein><FRAXA><Fragile X><Fragile X Mental Retardation 1 Gene><Fragile X Mental Retardation Protein><Fragile X Syndrome><Gene x Environment Interaction><Genetic><Genetic Change><Genetic Models><Genetic defect><Genetic mutation><Glia><Glial Cells><GxE interaction><Heritability><Human><Image><Impairment><Individual><Infantile Autism><Infiltration><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intracellular Communication and Signaling><Kanner's Syndrome><Kinases><Knock-out><Knockout><Kolliker's reticulum><LEOPARD Syndrome><Label><Learning><Life><Link><MAP Kinase Gene><MAPK><Maps><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Mediating><Memory><Messenger RNA><Mitogen-Activated Protein Kinase Gene><Modeling><Modern Man><Molecular><Multiple Lentigines><Multiple Lentigines Syndrome><Mutate><Mutation><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neuronal Transmission><Neurons><Neuropil><Non-Receptor Type 11 Protein Tyrosine Phosphatase><Non-neuronal cell><Nonneuronal cell><Noonan Syndrome><Odor Receptor Protein><Odorant Receptor Proteins><Odorant Receptors><Olfactory Receptor Proteins><Output><PKA><PTP-2 enzyme><PTP2C><PTPN11><PTPN11 gene><Pathway interactions><Phagocytes><Phagocytic Cell><Phagocytosis><Phase><Phosphatases><Phosphohydrolases><Phosphomonoesterases><Phosphoric Monoester Hydrolases><Phosphotransferase Gene><Phosphotransferases><Position><Positioning Attribute><Process><Protein Kinase A><Protein Tyrosine Phosphatase 2C><Protein-Tyrosine Phosphatase 2C><Proteins><Regulation><Regulatory Pathway><Renpenning syndrome 2><Reporter><Research><Resolution><Role><SHP2><SHP2 Phosphatase><SHPTP2><Sensory><Sensory Neurons><Shp-2 tyrosine phosphatase><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Synapses><Synaptic><System><Testing><Transgenic Organisms><Translations><Transmission Electron Microscopy><Transphosphorylases><Turner phenotype with normal karyotype><Turner syndrome in female with X chromosome><Turner-like syndrome><Tyrosine Phosphatase SHP2><Ullrich-Noonan syndrome><Visualization><Work><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><adulthood><amebocyte><autism spectral disorder><autism spectrum disorder><autism-fragile X (AFRAX) syndrome><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><biological sensor><biological signal transduction><brain circuitry><cAMP-Dependent Protein Kinases><critical period><disease model><disorder model><driving><environment effect on gene><experience><familial Turner syndrome><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X FMR1 protein><fragile X mental retardation 1><fragile X mental retardation-1 protein><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><fruit fly><gene environment interaction><gene interaction><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><genome mutation><glia signaling><glial activation><glial cell activation><glial signaling><imaging><in vivo><intellectual and developmental disability><juvenile><juvenile human><knock-down><knockdown><light microscopy><limited intellectual functioning><mRNA><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><male Turner syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><mutant><nerve cement><nerve signaling><neural circuit><neural circuitry><neural signaling><neurocircuitry><neuronal><neuronal circuit><neuronal circuitry><neuronal signaling><neurotransmission><optogenetics><pathway><programs><protein expression><pseudo-Ullrich-Turner syndrome><recruit><resolutions><sensory input><social role><synapse><synaptic circuit><synaptic circuitry><synaptic pruning><time use><tool><transgenic><translation>

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Shane R Crandall

MICHIGAN STATE UNIVERSITY, EAST LANSING, MI

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$384,209

FY 2026

Project Title

Dynamic properties of neural circuits in the forebrain

Grant Number:

5R01NS117636-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Nearly all sensory signals enter the neocortex by way of the thalamus, and the sensory cortex, in turn, distributes this information to several downstream cortical and subcortical areas. A prominent but often neglected feature of the sensory cortex is numerous feedback projections fr...

Research Terms

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Laura Bianchi

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, CORAL GABLES, FL

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$383,750

FY 2026

Project Title

Glial KCNQ channels.

Grant Number:

5R01NS127146-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract KCNQ channels are members of a conserved family of voltage-gated potassium channels. KCNQ2 through KCNQ5 subunits are expressed in the nervous system, where they regulate neuronal excitability. Epilepsy, autism, and other neurological conditions have been associated with mut...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AD dementia><ASD><Affect><Afferent Neurons><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Aminalon><Aminalone><Astrocytes><Astrocytus><Astroglia><Autism><Autistic Disorder><Behavioral><Behavioral Assay><Bipolar Affective Psychosis><Bipolar Disorder><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Cell Body><Cells><Complex><Consumption><DNA mutation><Data><Dedications><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encapsulated><Encephalopathies><Epilepsy><Epileptic Seizures><Epileptics><Familial Benign Neonatal Convulsions><Familial benign neonatal epilepsy><Family><Functional Imaging><GABA><GeneHomolog><Genes><Genetic Change><Genetic defect><Genetic mutation><Glia><Glial Cells><Goals><Heart><Heptylcarbinols><Homolog><Homologous Gene><Homologue><Human><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><Hydroxyoctanes><Image><Individual><Infantile Autism><K channel><Kanner's Syndrome><Knock-out><Knockout><Kolliker's reticulum><Link><Mammalia><Mammals><Manic-Depressive Psychosis><Membrane Potentials><Modern Man><Mutate><Mutation><Neonatal><Nerve Cells><Nerve Unit><Nervous System><Nervous System Physiology><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic><Neurologic Body System><Neurologic Organ System><Neurologic function><Neurological><Neurological function><Neurons><Neurophysiology / Electrophysiology><Non-neuronal cell><Nonneuronal cell><Octanols><Octyl Alcohols><Octylic Alcohols><Odors><Organ><Output><PIP2><Paralysis Agitans><Parkinson><Parkinson Disease><Pathogenicity><Pathology><Phenotype><Phosphatidylinositol 4,5-Biphosphate><Phosphatidylinositol 4,5-Diphosphate><Phosphatidylinositol-4,5-Bisphosphate><Physiologic><Physiologic Imaging><Physiological><Potassium Channel><Potassium Ion Channels><Primary Parkinsonism><Primary Senile Degenerative Dementia><Property><PtIns 4,5-P2><PtdInsP2><RNA Seq><RNA sequencing><RNAseq><Regulation><Rest><Resting Potentials><Role><Seizure Disorder><Sensory><Sensory Neurons><Structure><Testing><Time><Transmembrane Potentials><Voltage-Gated K+ Channels><Voltage-Gated Potassium Channel><Work><astrocytic glia><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><bipolar affective disorder><bipolar disease><bipolar illness><bipolar mood disorder><cell type><electrophysiological><epilepsia><epileptic encephalopathies><epileptogenic><experiment><experimental research><experimental study><experiments><gain of function><gamma-Aminobutyric Acid><gene manipulation><genetic approach><genetic manipulation><genetic strategy><genetically manipulate><genetically perturb><genome mutation><imaging><in vivo><knock-down><knockdown><loss of function mutation><manic depressive disorder><manic depressive illness><member><model organism><mutant><nerve cement><nervous system function><neuronal><neuronal excitability><neuropsychiatric><neuropsychiatry><pharmacologic><physiological imaging><primary degenerative dementia><response><senile dementia of the Alzheimer type><social role><transcriptome sequencing><transcriptomic sequencing><γ-Aminobutyric Acid>

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Kevin Yackle

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$361,625

FY 2026

Project Title

Determination of the motor patterning system for murine vocalizations with breathing

Grant Number:

5R01NS126400-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Our speech is composed of rhythmically timed elements, closely associated with syllables. This feature is conserved across the animal kingdom, from fish to songbirds to monkeys, suggesting that the tempo embedded within vocalizations is innately encoded. Indeed, others have hypothesized that the rhy...

Research Terms

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FREDERICK SHIC

SEATTLE CHILDREN'S HOSPITAL, SEATTLE, WA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$880,471

FY 2026

Project Title

Atypical Development in Infants and Toddlers: Computational Attentional Signatures through Mobile Eye Tracking

Grant Number:

5R01MH135568-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/7/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT This heterogeneity of autism spectrum disorder (ASD) results in challenges to developing diagnostic, prognostic, and treatment strategies applicable across the autism spectrum. A search has been underway for decades to identify promising biomarkers, i.e. objectively measured...

Research Terms

<0-11 years old><1st degree relative><2 year old><2 years of age><3 year old><3 years of age><ASD><Acceleration><Active Follow-up><Age Months><Algorithms><Animals><Attention><Autism><Autistic Disorder><Behavior assessment><Behavioral><Biological Markers><Biology><Care Givers><Caregivers><Child><Child Youth><Children (0-21)><Clinic><Clinical><Clinical assessments><Cognition><Cognitive><Collection><Communities><Computer Vision Systems><Computer software><Data><Data Collection><Development><Diagnosis><Diagnostic><Early Infantile Autism><Emotional><Equation><Evaluation><Face><Facial Expression><Family><Feedback><First Degree Relative><Friends><General Population><General Public><Geography><Goals><Heterogeneity><Home><Individual><Infant><Infantile Autism><Infrastructure><Interview><Kanner's Syndrome><Knowledge><Laboratories><Measures><Methods><Modeling><Monitor><Motivation><Movement><Nature><Neurodevelopmental Disorder><Neurological Development Disorder><Outcome><Parents><Participant><Pattern><Performance><Persons><Phone><Procedures><Process><Questionnaires><Reflex><Reflex action><Research><Research Methodology><Research Methods><Research Resources><Resources><Route><Sampling><Social Network><Software><Standardization><Structure><Survey Instrument><Surveys><System><Tablet Computer><Tablets><Task Performances><Technology><Telephone><Testing><Toddler><Translating><Visible Light><Visible Light Radiation><Visible Radiation><Visual attention><active followup><age 2><age 2 years><age 3><age 3 years><aged 2 years><aged two years><algorithm development><autism spectral disorder><autism spectrum disorder><autistic><autistic children><autistic spectrum disorder><automated assessment><automated evaluation><behavioral assessment><bio-markers><biologic marker><biomarker><body movement><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical phenotype><comparator group><comparison group><computer based prediction><computer vision><cost><cumulative risk><data infrastructure><data quality><data standardization><data standards><design><designing><developmental><early childhood><emotional expression><expression of emotion><eye tracking><face expression><faces><facial><follow up><follow-up><followed up><followup><gaze><handheld mobile device><homes><iPad><improved><individualized strategies><information gathering><infrastructure development><kids><machine learning based model><machine learning model><mobile device><neural network><neurodevelopmental disease><novel><optimal therapies><optimal treatments><parent><personalization of treatment><personalized medicine><personalized strategies><personalized therapy><personalized treatment><predictive modeling><preference><prognostic><recruit><research and methods><response to therapy><response to treatment><sex><showing emotion><skills><social><tablet device><therapeutic response><therapy response><three year old><three years of age><tool><treatment response><treatment responsiveness><treatment strategy><two year old><two years of age><usability><visual information><visual tracking><youngster>

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Chinfei Chen

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$869,580

FY 2026

Project Title

How do neurons in the brain decide to refine their synaptic connections in vivo?

Grant Number:

5R01MH111647-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/16/2017

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The formation of functional neural circuits is critical for the proper functioning of the brain. To establish the most efficient synaptic circuits, synaptic connections must be refined by neural activity during development. However, the manner and molecules by which synapse refinemen...

Research Terms

<2-photon><ASD><Adhesion Molecule><Anterior Quadrigeminal Body><Astrocytes><Astrocytus><Astroglia><Autism><Autistic Disorder><Axon><BEK fibroblast growth factor receptor><BEK protein tyrosine kinase><Biosensor><Brain><Brain Nervous System><Causality><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Communication and Signaling><Cell Signaling><Data><Defect><Development><Disease><Disorder><Dorsal><Dysfunction><EPH- and ELK-Related Tyrosine Kinase><EPH-and ELK-Related Kinase><Early Infantile Autism><Encephalon><Ephrin Type-A Receptor 8><Ephrin Type-A Receptor 8 Precursor><Equilibrium><Etiology><Eye><Eyeball><FGF-2 receptor><FGFR-2><Fibroblast Growth Factor Receptor 2><Functional disorder><Image><Impairment><In Vitro><Infantile Autism><Intracellular Communication and Signaling><JAK-2><JAK2><JAK2 gene><JAK2 protein><Janus kinase 2><Kanner's Syndrome><Lateral Geniculate Body><MFR gene><MFR protein><MYD-1><Macrophage Fusion Receptor><Mental disorders><Mental health disorders><Mice><Mice Mammals><Molecular><Murine><Mus><Mutant Strains Mice><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Optic Tectum><P84><PTPNS1><PTPNS1 gene><Pathway interactions><Pattern><Physiologic><Physiological><Physiopathology><Play><Process><Protein Tyrosine Kinase><Protein Tyrosine Kinase EEK><Protein-Tyrosine Phosphatase, Nonreceptor Type, Substrate 1><Psychiatric Disease><Psychiatric Disorder><Punishment><Regulation><Retina><Role><SHP Substrate 1><SHPS1><SIRP-Alpha-1><SIRPA><Schizophrenia><Schizophrenic Disorders><Signal Regulatory Protein, Alpha Type, 1><Signal Transduction><Signal Transduction Systems><Signaling><Site><Structure><Superior Colliculus><Synapses><Synaptic><System><Testing><Tyrosine Kinase><Tyrosine Phosphatase SHP Substrate 1><Tyrosine-Protein Kinase JAK2><Tyrosine-Protein Kinase Receptor EEK><Tyrosine-Specific Protein Kinase><Tyrosylprotein Kinase><Visual><Visual System><Visualization><Work><astrocytic glia><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><balance><balance function><bek fgf receptor kinase><bek fibroblast growth factor receptor kinase><bek-related fibroblast growth factor receptor-1><biological sensor><biological signal transduction><causation><cell adhesion protein><dementia praecox><design><designing><developmental><disease causation><experience><experiment><experimental research><experimental study><experiments><hydroxyaryl protein kinase><imaging><in vivo><insight><lateral geniculate><lateral geniculate nucleus><mental illness><mouse mutant><neural><neural circuit><neural circuitry><neural network><neurocircuitry><neurological disease><neuronal><neuropsychiatric disease><neuropsychiatric disorder><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathophysiology><pathway><post-synaptic nerves><post-synaptic neurons><postnatal><postsynaptic nerves><postsynaptic neurons><prevent><preventing><psychiatric illness><psychological disorder><response><retinogeniculate><schizophrenic><segregation><social role><superior colliculus Corpora quadrigemina><synapse><synapse formation><synaptic circuit><synaptic circuitry><synaptogenesis><tool><two-photon><tyrosyl protein kinase><visual tectum>

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Hisashi Umemori

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$869,580

FY 2026

Project Title

How do neurons in the brain decide to refine their synaptic connections in vivo?

Grant Number:

5R01MH111647-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/16/2017

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The formation of functional neural circuits is critical for the proper functioning of the brain. To establish the most efficient synaptic circuits, synaptic connections must be refined by neural activity during development. However, the manner and molecules by which synapse refinemen...

Research Terms

<2-photon><ASD><Adhesion Molecule><Anterior Quadrigeminal Body><Astrocytes><Astrocytus><Astroglia><Autism><Autistic Disorder><Axon><BEK fibroblast growth factor receptor><BEK protein tyrosine kinase><Biosensor><Brain><Brain Nervous System><Causality><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Communication and Signaling><Cell Signaling><Data><Defect><Development><Disease><Disorder><Dorsal><Dysfunction><EPH- and ELK-Related Tyrosine Kinase><EPH-and ELK-Related Kinase><Early Infantile Autism><Encephalon><Ephrin Type-A Receptor 8><Ephrin Type-A Receptor 8 Precursor><Equilibrium><Etiology><Eye><Eyeball><FGF-2 receptor><FGFR-2><Fibroblast Growth Factor Receptor 2><Functional disorder><Image><Impairment><In Vitro><Infantile Autism><Intracellular Communication and Signaling><JAK-2><JAK2><JAK2 gene><JAK2 protein><Janus kinase 2><Kanner's Syndrome><Lateral Geniculate Body><MFR gene><MFR protein><MYD-1><Macrophage Fusion Receptor><Mental disorders><Mental health disorders><Mice><Mice Mammals><Molecular><Murine><Mus><Mutant Strains Mice><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Optic Tectum><P84><PTPNS1><PTPNS1 gene><Pathway interactions><Pattern><Physiologic><Physiological><Physiopathology><Play><Process><Protein Tyrosine Kinase><Protein Tyrosine Kinase EEK><Protein-Tyrosine Phosphatase, Nonreceptor Type, Substrate 1><Psychiatric Disease><Psychiatric Disorder><Punishment><Regulation><Retina><Role><SHP Substrate 1><SHPS1><SIRP-Alpha-1><SIRPA><Schizophrenia><Schizophrenic Disorders><Signal Regulatory Protein, Alpha Type, 1><Signal Transduction><Signal Transduction Systems><Signaling><Site><Structure><Superior Colliculus><Synapses><Synaptic><System><Testing><Tyrosine Kinase><Tyrosine Phosphatase SHP Substrate 1><Tyrosine-Protein Kinase JAK2><Tyrosine-Protein Kinase Receptor EEK><Tyrosine-Specific Protein Kinase><Tyrosylprotein Kinase><Visual><Visual System><Visualization><Work><astrocytic glia><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><balance><balance function><bek fgf receptor kinase><bek fibroblast growth factor receptor kinase><bek-related fibroblast growth factor receptor-1><biological sensor><biological signal transduction><causation><cell adhesion protein><dementia praecox><design><designing><developmental><disease causation><experience><experiment><experimental research><experimental study><experiments><hydroxyaryl protein kinase><imaging><in vivo><insight><lateral geniculate><lateral geniculate nucleus><mental illness><mouse mutant><neural><neural circuit><neural circuitry><neural network><neurocircuitry><neurological disease><neuronal><neuropsychiatric disease><neuropsychiatric disorder><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathophysiology><pathway><post-synaptic nerves><post-synaptic neurons><postnatal><postsynaptic nerves><postsynaptic neurons><prevent><preventing><psychiatric illness><psychological disorder><response><retinogeniculate><schizophrenic><segregation><social role><superior colliculus Corpora quadrigemina><synapse><synapse formation><synaptic circuit><synaptic circuitry><synaptogenesis><tool><two-photon><tyrosyl protein kinase><visual tectum>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Judy Shih-Hwa Liu

BROWN UNIVERSITY, PROVIDENCE, RI

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$847,254

FY 2026

Project Title

ASH1L mediated transcription networks in autism spectrum disorders

Grant Number:

5R01MH127081-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Genetic research in autism spectrum disorder (ASD) has led to the discovery of a growing list of highly penetrant mutations in chromatin modifiers and transcription factors. This recent progress provides an important opportunity to define the molecular mechanisms in ASD, as well as to ident...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sofia Beatriz Lizarraga

BROWN UNIVERSITY, PROVIDENCE, RI

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$847,254

FY 2026

Project Title

ASH1L mediated transcription networks in autism spectrum disorders

Grant Number:

5R01MH127081-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Genetic research in autism spectrum disorder (ASD) has led to the discovery of a growing list of highly penetrant mutations in chromatin modifiers and transcription factors. This recent progress provides an important opportunity to define the molecular mechanisms in ASD, as well as to ident...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Andrew S Fox

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$803,128

FY 2026

Project Title

Brain Aging Across the Lifespan in Neurodevelopmental Disorders

Grant Number:

5R01MH133068-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/20/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Autism spectrum disorder (ASD) is typically described as a disorder of childhood; however, challenges in socioemotional behavior and cognition persist across the lifespan. Nearly 6 million adults in the United States currently live with ASD, with prevalence more than doubling in the last 10...

Research Terms

<12-20 years old><21+ years old><ASD><Adolescence><Adult><Adult Human><Affect><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer beta-Protein><Alzheimer's Amyloid beta-Protein><Alzheimer's amyloid><Amentia><Ammon Horn><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Anterior><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Array tomography><Assay><Autism><Autistic Disorder><Autopsy><Aβ><Aβ burden><Behavioral><Benign senescent forgetfulness><Bioassay><Biological Assay><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Count><Cell Nucleus><Cell Number><Cell Signaling><Cells><Cellular injury><Childhood><Chronic><Clinical><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Cornu Ammonis><Data><Dementia><Development><Disease><Disorder><Disturbance in cognition><Dysfunction><Early Infantile Autism><Emotional><Encephalon><Encephalon Diseases><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Functional disorder><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Goals><Growth><Hippocampus><Hortega cell><Human><IFN-Gamma-Inducing Factor Gene><IFN-gamma-Inducing Factor><IGIF><IGIF Gene><IL-1 Gamma><IL-1 Gamma Gene><IL-18><IL-18 Gene><IL-1g><IL-1g Gene><IL18><IL18 Protein><IL18 gene><IL1F4><IL1F4 Gene><Immune Cell Activation><Immunofluorescence><Immunofluorescence Immunologic><Immunoglobulin Enhancer-Binding Protein><Impaired cognition><Impairment><Infantile Autism><Inflammatory><Interferon-Gamma-Inducing Factor Gene><Interferon-gamma-Inducing Factor><Interleukin 18 (Interferon-Gamma-Inducing Factor)><Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene><Interleukin 18 Proprotein><Interleukin 18 Proprotein Gene><Interleukin-1 Gamma><Interleukin-1 Gamma Gene><Interleukin-18><Interleukin-18 Precursor><Interleukin-18 Precursor Gene><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><MGC12320><MGC12320 Gene><MT-bound tau><Maps><Medial><Methods><Microglia><Modern Man><Molecular><Myelin><NF-kB><NF-kappa B><NF-kappaB><NFKB><Nerve Cells><Nerve Degeneration><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neuroimmune><Neurological Development Disorder><Neuron Degeneration><Neuronal Transmission><Neurons><Neuropil><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Nucleus><Pathogenicity><Pathologic><Pathway interactions><Pattern><Phenotype><Physiopathology><Population><Prevalence><Process><Proteins><Proteomics><Publishing><RNA Expression><Receptor Protein><Regulatory Pathway><Research><Risk><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Spinal Column><Spine><Staining method><Stains><Stress><Structure><Study models><Synapses><Synaptic><System><Techniques><Thick><Thickness><Tissue Growth><Transcript><Transcription><Transcription Factor NF-kB><United States><Vertebral column><a beta peptide><a-beta burden><aberrant aging><abeta><abeta accumulation><abeta aggregation><abeta burden><abnormal aging><adolescence (12-20)><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age associated><age associated alterations><age associated changes><age associated cognitive impairment><age associated difference><age associated memory decline><age associated memory deficit><age based difference><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent difference><age dependent variation><age difference><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related difference><age related memory dysfunction><age related variation><age specific><age specific alterations><age specific changes><age specific difference><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><aged brain><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related cognitive decline><aging specific alterations><aging specific changes><alterations with age><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid burden><amyloid β accumulation><amyloid β aggregation><amyloid-b protein><autism spectral disorder><autism spectrum disorder><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><aβ accumulation><aβ aggregation><backbone><beta amyloid burden><beta amyloid fibril><biological signal transduction><brain control><brain tissue><brain volume><cell damage><cell injury><cell type><cellular damage><changes with age><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cognitive dysfunction><cognitive loss><comparative><cytokine><damage to cells><data reduction><declining cognitive functions with aging><density><developmental><differ by age><difference across age><difference in age><differential expression><differentially expressed><dysfunctional age related change><dysfunctional aging><early adulthood><emerging adult><emotional behavior><genetic information><gitter cell><glia signaling><glial signaling><healthspan extending intervention><healthspan extending therapies><healthspan intervention><healthspan promoting intervention><healthspan promoting therapies><healthspan therapies><healthy aging><healthy aging intervention><healthy human aging><hippocampal><immune activation><impaired aging><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><injury to cells><insoluble aggregate><intervention to promote healthy aging><interventions to improve healthspan><kappa B Enhancer Binding Protein><life span><lifespan><maladaptive aging><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><model of animal><necropsy><nerve signaling><neural degeneration><neural inflammation><neural signaling><neurobiological><neurodegeneration><neurodegenerative><neurodevelopmental disease><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal><neuronal degeneration><neuronal signaling><neuropathologic><neuropathological><neuropathology><neurotransmission><novel><nuclear factor kappa beta><ontogeny><pathological age related changes><pathological aging><pathophysiology><pathway><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><perivascular glial cell><postmortem><precision medicine><precision-based medicine><preservation><protein aggregate><protein aggregation><receptor><response><sNuc-Seq><sex><single molecule><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><soluble amyloid precursor protein><super high resolution><superresolution><synapse><tau><tau Proteins><tau factor><transcriptional differences><transcriptomics><ultra high resolution><variation by age><β-amyloid burden><βamyloid burden><τ Proteins>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

KARL Daniel MURRAY

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$803,128

FY 2026

Project Title

Brain Aging Across the Lifespan in Neurodevelopmental Disorders

Grant Number:

5R01MH133068-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/20/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Autism spectrum disorder (ASD) is typically described as a disorder of childhood; however, challenges in socioemotional behavior and cognition persist across the lifespan. Nearly 6 million adults in the United States currently live with ASD, with prevalence more than doubling in the last 10...

Research Terms

<12-20 years old><21+ years old><ASD><Adolescence><Adult><Adult Human><Affect><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer beta-Protein><Alzheimer's Amyloid beta-Protein><Alzheimer's amyloid><Amentia><Ammon Horn><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Anterior><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Array tomography><Assay><Autism><Autistic Disorder><Autopsy><Aβ><Aβ burden><Behavioral><Benign senescent forgetfulness><Bioassay><Biological Assay><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Count><Cell Nucleus><Cell Number><Cell Signaling><Cells><Cellular injury><Childhood><Chronic><Clinical><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Cornu Ammonis><Data><Dementia><Development><Disease><Disorder><Disturbance in cognition><Dysfunction><Early Infantile Autism><Emotional><Encephalon><Encephalon Diseases><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Functional disorder><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Goals><Growth><Hippocampus><Hortega cell><Human><IFN-Gamma-Inducing Factor Gene><IFN-gamma-Inducing Factor><IGIF><IGIF Gene><IL-1 Gamma><IL-1 Gamma Gene><IL-18><IL-18 Gene><IL-1g><IL-1g Gene><IL18><IL18 Protein><IL18 gene><IL1F4><IL1F4 Gene><Immune Cell Activation><Immunofluorescence><Immunofluorescence Immunologic><Immunoglobulin Enhancer-Binding Protein><Impaired cognition><Impairment><Infantile Autism><Inflammatory><Interferon-Gamma-Inducing Factor Gene><Interferon-gamma-Inducing Factor><Interleukin 18 (Interferon-Gamma-Inducing Factor)><Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene><Interleukin 18 Proprotein><Interleukin 18 Proprotein Gene><Interleukin-1 Gamma><Interleukin-1 Gamma Gene><Interleukin-18><Interleukin-18 Precursor><Interleukin-18 Precursor Gene><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><MGC12320><MGC12320 Gene><MT-bound tau><Maps><Medial><Methods><Microglia><Modern Man><Molecular><Myelin><NF-kB><NF-kappa B><NF-kappaB><NFKB><Nerve Cells><Nerve Degeneration><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neuroimmune><Neurological Development Disorder><Neuron Degeneration><Neuronal Transmission><Neurons><Neuropil><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Nucleus><Pathogenicity><Pathologic><Pathway interactions><Pattern><Phenotype><Physiopathology><Population><Prevalence><Process><Proteins><Proteomics><Publishing><RNA Expression><Receptor Protein><Regulatory Pathway><Research><Risk><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Spinal Column><Spine><Staining method><Stains><Stress><Structure><Study models><Synapses><Synaptic><System><Techniques><Thick><Thickness><Tissue Growth><Transcript><Transcription><Transcription Factor NF-kB><United States><Vertebral column><a beta peptide><a-beta burden><aberrant aging><abeta><abeta accumulation><abeta aggregation><abeta burden><abnormal aging><adolescence (12-20)><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age associated><age associated alterations><age associated changes><age associated cognitive impairment><age associated difference><age associated memory decline><age associated memory deficit><age based difference><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent difference><age dependent variation><age difference><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related difference><age related memory dysfunction><age related variation><age specific><age specific alterations><age specific changes><age specific difference><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><aged brain><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related cognitive decline><aging specific alterations><aging specific changes><alterations with age><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid burden><amyloid β accumulation><amyloid β aggregation><amyloid-b protein><autism spectral disorder><autism spectrum disorder><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><aβ accumulation><aβ aggregation><backbone><beta amyloid burden><beta amyloid fibril><biological signal transduction><brain control><brain tissue><brain volume><cell damage><cell injury><cell type><cellular damage><changes with age><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cognitive dysfunction><cognitive loss><comparative><cytokine><damage to cells><data reduction><declining cognitive functions with aging><density><developmental><differ by age><difference across age><difference in age><differential expression><differentially expressed><dysfunctional age related change><dysfunctional aging><early adulthood><emerging adult><emotional behavior><genetic information><gitter cell><glia signaling><glial signaling><healthspan extending intervention><healthspan extending therapies><healthspan intervention><healthspan promoting intervention><healthspan promoting therapies><healthspan therapies><healthy aging><healthy aging intervention><healthy human aging><hippocampal><immune activation><impaired aging><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><injury to cells><insoluble aggregate><intervention to promote healthy aging><interventions to improve healthspan><kappa B Enhancer Binding Protein><life span><lifespan><maladaptive aging><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><model of animal><necropsy><nerve signaling><neural degeneration><neural inflammation><neural signaling><neurobiological><neurodegeneration><neurodegenerative><neurodevelopmental disease><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal><neuronal degeneration><neuronal signaling><neuropathologic><neuropathological><neuropathology><neurotransmission><novel><nuclear factor kappa beta><ontogeny><pathological age related changes><pathological aging><pathophysiology><pathway><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><perivascular glial cell><postmortem><precision medicine><precision-based medicine><preservation><protein aggregate><protein aggregation><receptor><response><sNuc-Seq><sex><single molecule><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><soluble amyloid precursor protein><super high resolution><superresolution><synapse><tau><tau Proteins><tau factor><transcriptional differences><transcriptomics><ultra high resolution><variation by age><β-amyloid burden><βamyloid burden><τ Proteins>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Cynthia Schumann

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$803,128

FY 2026

Project Title

Brain Aging Across the Lifespan in Neurodevelopmental Disorders

Grant Number:

5R01MH133068-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/20/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Autism spectrum disorder (ASD) is typically described as a disorder of childhood; however, challenges in socioemotional behavior and cognition persist across the lifespan. Nearly 6 million adults in the United States currently live with ASD, with prevalence more than doubling in the last 10...

Research Terms

<12-20 years old><21+ years old><ASD><Adolescence><Adult><Adult Human><Affect><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer beta-Protein><Alzheimer's Amyloid beta-Protein><Alzheimer's amyloid><Amentia><Ammon Horn><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Anterior><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Array tomography><Assay><Autism><Autistic Disorder><Autopsy><Aβ><Aβ burden><Behavioral><Benign senescent forgetfulness><Bioassay><Biological Assay><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Count><Cell Nucleus><Cell Number><Cell Signaling><Cells><Cellular injury><Childhood><Chronic><Clinical><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Cornu Ammonis><Data><Dementia><Development><Disease><Disorder><Disturbance in cognition><Dysfunction><Early Infantile Autism><Emotional><Encephalon><Encephalon Diseases><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Functional disorder><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Goals><Growth><Hippocampus><Hortega cell><Human><IFN-Gamma-Inducing Factor Gene><IFN-gamma-Inducing Factor><IGIF><IGIF Gene><IL-1 Gamma><IL-1 Gamma Gene><IL-18><IL-18 Gene><IL-1g><IL-1g Gene><IL18><IL18 Protein><IL18 gene><IL1F4><IL1F4 Gene><Immune Cell Activation><Immunofluorescence><Immunofluorescence Immunologic><Immunoglobulin Enhancer-Binding Protein><Impaired cognition><Impairment><Infantile Autism><Inflammatory><Interferon-Gamma-Inducing Factor Gene><Interferon-gamma-Inducing Factor><Interleukin 18 (Interferon-Gamma-Inducing Factor)><Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene><Interleukin 18 Proprotein><Interleukin 18 Proprotein Gene><Interleukin-1 Gamma><Interleukin-1 Gamma Gene><Interleukin-18><Interleukin-18 Precursor><Interleukin-18 Precursor Gene><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><MGC12320><MGC12320 Gene><MT-bound tau><Maps><Medial><Methods><Microglia><Modern Man><Molecular><Myelin><NF-kB><NF-kappa B><NF-kappaB><NFKB><Nerve Cells><Nerve Degeneration><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neuroimmune><Neurological Development Disorder><Neuron Degeneration><Neuronal Transmission><Neurons><Neuropil><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Nucleus><Pathogenicity><Pathologic><Pathway interactions><Pattern><Phenotype><Physiopathology><Population><Prevalence><Process><Proteins><Proteomics><Publishing><RNA Expression><Receptor Protein><Regulatory Pathway><Research><Risk><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Spinal Column><Spine><Staining method><Stains><Stress><Structure><Study models><Synapses><Synaptic><System><Techniques><Thick><Thickness><Tissue Growth><Transcript><Transcription><Transcription Factor NF-kB><United States><Vertebral column><a beta peptide><a-beta burden><aberrant aging><abeta><abeta accumulation><abeta aggregation><abeta burden><abnormal aging><adolescence (12-20)><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age associated><age associated alterations><age associated changes><age associated cognitive impairment><age associated difference><age associated memory decline><age associated memory deficit><age based difference><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent difference><age dependent variation><age difference><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related difference><age related memory dysfunction><age related variation><age specific><age specific alterations><age specific changes><age specific difference><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><aged brain><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related cognitive decline><aging specific alterations><aging specific changes><alterations with age><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid burden><amyloid β accumulation><amyloid β aggregation><amyloid-b protein><autism spectral disorder><autism spectrum disorder><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><aβ accumulation><aβ aggregation><backbone><beta amyloid burden><beta amyloid fibril><biological signal transduction><brain control><brain tissue><brain volume><cell damage><cell injury><cell type><cellular damage><changes with age><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cognitive dysfunction><cognitive loss><comparative><cytokine><damage to cells><data reduction><declining cognitive functions with aging><density><developmental><differ by age><difference across age><difference in age><differential expression><differentially expressed><dysfunctional age related change><dysfunctional aging><early adulthood><emerging adult><emotional behavior><genetic information><gitter cell><glia signaling><glial signaling><healthspan extending intervention><healthspan extending therapies><healthspan intervention><healthspan promoting intervention><healthspan promoting therapies><healthspan therapies><healthy aging><healthy aging intervention><healthy human aging><hippocampal><immune activation><impaired aging><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><injury to cells><insoluble aggregate><intervention to promote healthy aging><interventions to improve healthspan><kappa B Enhancer Binding Protein><life span><lifespan><maladaptive aging><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><model of animal><necropsy><nerve signaling><neural degeneration><neural inflammation><neural signaling><neurobiological><neurodegeneration><neurodegenerative><neurodevelopmental disease><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal><neuronal degeneration><neuronal signaling><neuropathologic><neuropathological><neuropathology><neurotransmission><novel><nuclear factor kappa beta><ontogeny><pathological age related changes><pathological aging><pathophysiology><pathway><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><perivascular glial cell><postmortem><precision medicine><precision-based medicine><preservation><protein aggregate><protein aggregation><receptor><response><sNuc-Seq><sex><single molecule><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><soluble amyloid precursor protein><super high resolution><superresolution><synapse><tau><tau Proteins><tau factor><transcriptional differences><transcriptomics><ultra high resolution><variation by age><β-amyloid burden><βamyloid burden><τ Proteins>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Daniel Patrick Kennedy

TRUSTEES OF INDIANA UNIVERSITY, BLOOMINGTON, IN

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$780,304

FY 2026

Project Title

Using complex video stimuli to elucidate atypical brain functioning in ASD

Grant Number:

5R01MH110630-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2017

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY: The discovery and reﬁnement of brain-based signatures of autism spectrum disorder (ASD) has for many years been a highly desired, but as yet elusive, goal. One key challenge identiﬁed has been that numerous levels and sources of variability — between sites, between participants, and within ...

Research Terms

View Full Project Details on NIH Reporter

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Stephen Edward Paucha Smith

SEATTLE CHILDREN'S HOSPITAL, SEATTLE, WA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$778,237

FY 2026

Project Title

Investigating the synaptic pathology of Autism

Grant Number:

5R01MH113545-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2017

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Genetic mutations that confer autism (ASD) risk often occur in genes that comprise signal transduction networks that link synaptic transmission to downstream changes in gene expression. However, the dynamic, network- scale behavior of these complex and interconnected signaling networ...

Research Terms

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Alon Goren

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$778,227

FY 2026

Project Title

Novel SETD5-based Molecular Mechanisms and Therapeutic Tools to Understand and Revert Neuronal Dysfunction Associated with Intellectual disability and Autism

Grant Number:

5R01MH127077-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/5/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Autism spectrum disorder (ASD), which is usually accompanied of intellectual disability (ID), is part of a group of neurodevelopmental disorders that are usually diagnosed during the first two years of age. The social, emotional and communication skills of affected individuals are se...

Research Terms

<0-11 years old><2 year old><2 years of age><ASD><ATAC sequencing><ATAC-seq><ATACseq><Acute><Address><Affect><Antisense Agent><Antisense Oligonucleotides><Appearance><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Astrocytes><Astrocytus><Astroglia><Attenuated><Autism><Autistic Disorder><Automobile Driving><Autoregulation><B-Cell Differentiation Factor Gene><B-Cell Stimulatory Factor 2 Gene><BSF-2 Gene><BSF2 Gene><Behavior><Behavioral><Beta-2 Gene Interferon><Binding><Bioassay><Biochemical><Biological Assay><Brain><Brain Nervous System><CRISPR activation><CRISPR activator><CRISPR approach><CRISPR based activation><CRISPR based approach><CRISPR gene activation><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-CAS-9><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR-dCAS9 Activator><CRISPR-mediated transcriptional activation><CRISPR/CAS approach><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CRISPR/dCas9 activation><CRISPR/dCas9-based transcriptional activation><CRISPRa><Cas nuclease technology><Catalogs><Causality><Cell Body><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Child><Child Development><Child Youth><Children (0-21)><Chromatin><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><Communication challenge><Communication difficulty><Compensation><Complex><DNA mutation><Defect><Development><Diagnosis><Disease><Disorder><Disturbance in cognition><Drug Screening><Dysfunction><EC 2.1.1><Early Infantile Autism><Early Intervention><Electrophysiology><Electrophysiology (science)><Emotional><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epilepsy><Epileptic Seizures><Epileptics><Ethnic Origin><Ethnicity><Etiology><Failure><Family><Financial Hardship><Functional disorder><GRO-seq><GROseq><Gene Targeting><Gene variant><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Variation><Genetic defect><Genetic mutation><Genome><Genomics><Goals><HSF Gene><Hepatocyte Stimulatory Factor Gene><Heterogeneity><Histones><Homeostasis><Human><Human Development><Hybridoma Growth Factor Gene><IFNB2 Gene><IL-6 Gene><IL6><IL6 gene><Impaired cognition><Impairment><In Vitro><Individual><Infant and Child Development><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Interleukin 6 (Interferon, Beta 2) Gene><Interleukin-6 Gene><Interpersonal Interaction><Interpersonal Relations><JAK kinase><Janus kinase><Kanner's Syndrome><Knowledge><L-Lysine><Life><Link><Lysine><Mediating><Methods><Methyltransferase><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Interaction><Motor><Murine><Mus><Mutate><Mutation><N-CoR protein><NCOR1><NCOR1 gene><NCoR protein><NPC><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Dysfunction><Neurons><Neurophysiology / Electrophysiology><Nuclear Pore Complex><Nuclear Receptor Corepressor 1><Optics><Outcome><Paf1><Pathology><Pathway interactions><Physiological Homeostasis><Physiology><Physiopathology><Play><Process><Public Health><RIP13 protein><RNA Processing><Race><Races><Recovery><Regulator Genes><Research><Risk-associated variant><Role><SET Domain><Seizure Disorder><Sensory><Severities><Stereotyping><Structure><System><Technology><Testing><Therapeutic><Therapeutic Intervention><Time><Transcription Elongation><Transcriptional Regulatory Elements><Translations><United States><Visualization><abnormal brain function><activating CRISPR technology><age 2><age 2 years><aged 2 years><aged two years><allelic variant><antisense oligo><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><astrocytic glia><attenuate><attenuates><attenuation><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><brain cell><brain dysfunction><brain impairment><catalog><causation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chromatin remodeling><cognitive dysfunction><cognitive loss><cost><debilitating symptom><design><designing><developmental><disease causation><disease risk><disorder risk><driving><dysfunctional brain><economic hardship><economic strain><effective therapy><effective treatment><electrophysiological><epigenetically><epilepsia><epileptogenic><experience><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><genetic trans acting element><genetic variant><genome editing><genome mutation><genomic editing><genomic tools><genomic variant><global run on sequencing><global run on transcription sequencing><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><improved><induced human pluripotent stem cells><intellectual and developmental disability><interpersonal relationship><intervention therapy><kids><kinase inhibitor><limited intellectual functioning><loss of function><methylase><motor impairment><mouse model><movement impairment><movement limitation><multiomics><multiple omics><murine model><neural><neural dysfunction><neurodevelopmental disease><neuron toxicity><neuronal><neuronal toxicity><neurotoxic><neurotoxicity><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><nuclear receptor co-repressor><optical><pancreatic differentiation 2><pancreatic differentiation 2 protein><panomics><pathophysiology><pathway><pharmacologic><polymerase associated factor 1><prevent><preventing><psychologic><psychological><racial><racial background><racial origin><regulatory gene><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scRNA sequencing><scRNA-seq><service intervention><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><synapse formation><synaptogenesis><therapeutic target><tool><trait><trans acting element><translation><transmethylase><two year old><two years of age><youngster>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Alysson R. Muotri

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$778,227

FY 2026

Project Title

Novel SETD5-based Molecular Mechanisms and Therapeutic Tools to Understand and Revert Neuronal Dysfunction Associated with Intellectual disability and Autism

Grant Number:

5R01MH127077-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/5/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Autism spectrum disorder (ASD), which is usually accompanied of intellectual disability (ID), is part of a group of neurodevelopmental disorders that are usually diagnosed during the first two years of age. The social, emotional and communication skills of affected individuals are se...

Research Terms

<0-11 years old><2 year old><2 years of age><ASD><ATAC sequencing><ATAC-seq><ATACseq><Acute><Address><Affect><Antisense Agent><Antisense Oligonucleotides><Appearance><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Astrocytes><Astrocytus><Astroglia><Attenuated><Autism><Autistic Disorder><Automobile Driving><Autoregulation><B-Cell Differentiation Factor Gene><B-Cell Stimulatory Factor 2 Gene><BSF-2 Gene><BSF2 Gene><Behavior><Behavioral><Beta-2 Gene Interferon><Binding><Bioassay><Biochemical><Biological Assay><Brain><Brain Nervous System><CRISPR activation><CRISPR activator><CRISPR approach><CRISPR based activation><CRISPR based approach><CRISPR gene activation><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-CAS-9><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR-dCAS9 Activator><CRISPR-mediated transcriptional activation><CRISPR/CAS approach><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CRISPR/dCas9 activation><CRISPR/dCas9-based transcriptional activation><CRISPRa><Cas nuclease technology><Catalogs><Causality><Cell Body><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Child><Child Development><Child Youth><Children (0-21)><Chromatin><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><Communication challenge><Communication difficulty><Compensation><Complex><DNA mutation><Defect><Development><Diagnosis><Disease><Disorder><Disturbance in cognition><Drug Screening><Dysfunction><EC 2.1.1><Early Infantile Autism><Early Intervention><Electrophysiology><Electrophysiology (science)><Emotional><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epilepsy><Epileptic Seizures><Epileptics><Ethnic Origin><Ethnicity><Etiology><Failure><Family><Financial Hardship><Functional disorder><GRO-seq><GROseq><Gene Targeting><Gene variant><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Variation><Genetic defect><Genetic mutation><Genome><Genomics><Goals><HSF Gene><Hepatocyte Stimulatory Factor Gene><Heterogeneity><Histones><Homeostasis><Human><Human Development><Hybridoma Growth Factor Gene><IFNB2 Gene><IL-6 Gene><IL6><IL6 gene><Impaired cognition><Impairment><In Vitro><Individual><Infant and Child Development><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Interleukin 6 (Interferon, Beta 2) Gene><Interleukin-6 Gene><Interpersonal Interaction><Interpersonal Relations><JAK kinase><Janus kinase><Kanner's Syndrome><Knowledge><L-Lysine><Life><Link><Lysine><Mediating><Methods><Methyltransferase><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Interaction><Motor><Murine><Mus><Mutate><Mutation><N-CoR protein><NCOR1><NCOR1 gene><NCoR protein><NPC><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Dysfunction><Neurons><Neurophysiology / Electrophysiology><Nuclear Pore Complex><Nuclear Receptor Corepressor 1><Optics><Outcome><Paf1><Pathology><Pathway interactions><Physiological Homeostasis><Physiology><Physiopathology><Play><Process><Public Health><RIP13 protein><RNA Processing><Race><Races><Recovery><Regulator Genes><Research><Risk-associated variant><Role><SET Domain><Seizure Disorder><Sensory><Severities><Stereotyping><Structure><System><Technology><Testing><Therapeutic><Therapeutic Intervention><Time><Transcription Elongation><Transcriptional Regulatory Elements><Translations><United States><Visualization><abnormal brain function><activating CRISPR technology><age 2><age 2 years><aged 2 years><aged two years><allelic variant><antisense oligo><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><astrocytic glia><attenuate><attenuates><attenuation><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><brain cell><brain dysfunction><brain impairment><catalog><causation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chromatin remodeling><cognitive dysfunction><cognitive loss><cost><debilitating symptom><design><designing><developmental><disease causation><disease risk><disorder risk><driving><dysfunctional brain><economic hardship><economic strain><effective therapy><effective treatment><electrophysiological><epigenetically><epilepsia><epileptogenic><experience><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><genetic trans acting element><genetic variant><genome editing><genome mutation><genomic editing><genomic tools><genomic variant><global run on sequencing><global run on transcription sequencing><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><improved><induced human pluripotent stem cells><intellectual and developmental disability><interpersonal relationship><intervention therapy><kids><kinase inhibitor><limited intellectual functioning><loss of function><methylase><motor impairment><mouse model><movement impairment><movement limitation><multiomics><multiple omics><murine model><neural><neural dysfunction><neurodevelopmental disease><neuron toxicity><neuronal><neuronal toxicity><neurotoxic><neurotoxicity><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><nuclear receptor co-repressor><optical><pancreatic differentiation 2><pancreatic differentiation 2 protein><panomics><pathophysiology><pathway><pharmacologic><polymerase associated factor 1><prevent><preventing><psychologic><psychological><racial><racial background><racial origin><regulatory gene><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><scRNA sequencing><scRNA-seq><service intervention><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><synapse formation><synaptogenesis><therapeutic target><tool><trait><trans acting element><translation><transmethylase><two year old><two years of age><youngster>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

MICHAEL PHILIP EPSTEIN

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$767,553

FY 2026

Project Title

The schizophrenia-associated 3q29 deletion: genetic architecture of behavioral phenotypes

Grant Number:

5R01MH126449-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/24/2023

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary 3q29 deletion syndrome is caused by a typically de novo 1.6 Mb deletion of 21 genes. The syndrome is associated with an astonishing 40-fold increased risk for schizophrenia, as well as cognitive disability, a high rate of autism and social disability, executive function deficits and pronounc...

Research Terms

<1q21><22q11.2><3q29><AD/HD><ADHD><ASD><Address><Anxiety Disorders><Articulation><Attention deficit hyperactivity disorder><Attenuated><Autism><Autistic Disorder><Basic Research><Basic Science><Biological><Biology><Brain Diseases><Brain Disorders><Caring><Collaborations><Collection><Communities><DNA><Data><Deoxyribonucleic Acid><Development><Dimensions><Disease><Disorder><Early Infantile Autism><Encephalon Diseases><Enrollment><Ensure><Evaluation><Executive Dysfunction><Executive Function Deficit><Executive Impairment><Exhibits><Feasibility Studies><Frequencies><Genes><Genetic><Genomics><Genotype><Goals><Heterogeneity><Individual><Infantile Autism><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Investigation><Kanner's Syndrome><Knowledge><Lesion><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><NIMH><National Institute of Mental Health><Neurodevelopmental Disorder><Neurological Development Disorder><Parents><Phenotype><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prevalence><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychoses><Psychotic Disorders><Registries><Risk><Sampling><Sampling Studies><Schizophrenia><Schizophrenic Disorders><Severities><Side><Site><Social Behavior><Social Functioning><Social disability><Study Subject><Survey Instrument><Surveys><Symptoms><Syndrome><Testing><Travel><Universities><Work><attenuate><attenuates><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior phenotype><behavioral phenotyping><biologic><burden of disease><burden of illness><clinical phenotype><clinical significance><clinical translation><clinically significant><clinically translatable><co-morbid><co-morbidity><cognitive ability><cognitive disability><cognitively disabled><cohort><comorbidity><cost><database of Genotypes and Phenotypes><dbGaP><dementia praecox><developmental><disease burden><enroll><entire genome><executive control><executive function><experience><full genome><function socially><functioning social><genetic architecture><genome sequencing><high risk><high risk group><high risk individual><high risk people><high risk population><improved><low-frequency mutation><mental illness><neurodevelopmental disease><neuropsychiatric><neuropsychiatric disease><neuropsychiatric disorder><neuropsychiatry><pandemic><pandemic disease><parent><patient mobility><phenotypic data><proband><psychiatric illness><psychological disorder><psychosis risk><psychotic illness><public data base><public database><publicly accessible data base><publicly accessible database><publicly available data base><publicly available database><rare allele><rare genetic disease><rare genetic disorder><rare mutation><rare variant><recruit><remote assessment><remote evaluation><schizophrenia risk><schizophrenic><sex><sociobehavior><sociobehavioral><whole genome>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jennifer Gladys Mulle

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$767,553

FY 2026

Project Title

The schizophrenia-associated 3q29 deletion: genetic architecture of behavioral phenotypes

Grant Number:

5R01MH126449-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/24/2023

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary 3q29 deletion syndrome is caused by a typically de novo 1.6 Mb deletion of 21 genes. The syndrome is associated with an astonishing 40-fold increased risk for schizophrenia, as well as cognitive disability, a high rate of autism and social disability, executive function deficits and pronounc...

Research Terms

<1q21><22q11.2><3q29><AD/HD><ADHD><ASD><Address><Anxiety Disorders><Articulation><Attention deficit hyperactivity disorder><Attenuated><Autism><Autistic Disorder><Basic Research><Basic Science><Biological><Biology><Brain Diseases><Brain Disorders><Caring><Collaborations><Collection><Communities><DNA><Data><Deoxyribonucleic Acid><Development><Dimensions><Disease><Disorder><Early Infantile Autism><Encephalon Diseases><Enrollment><Ensure><Evaluation><Executive Dysfunction><Executive Function Deficit><Executive Impairment><Exhibits><Feasibility Studies><Frequencies><Genes><Genetic><Genomics><Genotype><Goals><Heterogeneity><Individual><Infantile Autism><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Investigation><Kanner's Syndrome><Knowledge><Lesion><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><NIMH><National Institute of Mental Health><Neurodevelopmental Disorder><Neurological Development Disorder><Parents><Phenotype><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prevalence><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychoses><Psychotic Disorders><Registries><Risk><Sampling><Sampling Studies><Schizophrenia><Schizophrenic Disorders><Severities><Side><Site><Social Behavior><Social Functioning><Social disability><Study Subject><Survey Instrument><Surveys><Symptoms><Syndrome><Testing><Travel><Universities><Work><attenuate><attenuates><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior phenotype><behavioral phenotyping><biologic><burden of disease><burden of illness><clinical phenotype><clinical significance><clinical translation><clinically significant><clinically translatable><co-morbid><co-morbidity><cognitive ability><cognitive disability><cognitively disabled><cohort><comorbidity><cost><database of Genotypes and Phenotypes><dbGaP><dementia praecox><developmental><disease burden><enroll><entire genome><executive control><executive function><experience><full genome><function socially><functioning social><genetic architecture><genome sequencing><high risk><high risk group><high risk individual><high risk people><high risk population><improved><low-frequency mutation><mental illness><neurodevelopmental disease><neuropsychiatric><neuropsychiatric disease><neuropsychiatric disorder><neuropsychiatry><pandemic><pandemic disease><parent><patient mobility><phenotypic data><proband><psychiatric illness><psychological disorder><psychosis risk><psychotic illness><public data base><public database><publicly accessible data base><publicly accessible database><publicly available data base><publicly available database><rare allele><rare genetic disease><rare genetic disorder><rare mutation><rare variant><recruit><remote assessment><remote evaluation><schizophrenia risk><schizophrenic><sex><sociobehavior><sociobehavioral><whole genome>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jason Louis Stein

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$752,255

FY 2026

Project Title

IBIS-iPSC: Organoid modeling of cortical surface area hyperexpansion in autism spectrum disorder

Grant Number:

5R01MH130441-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Many individuals with monogenic and idiopathic forms of autism spectrum disorder (ASD) exhibit brain enlargement early in life. However, the underlying cellular and molecular mechanisms leading to early brain overgrowth in ASD are unknown. To identify the mechanisms leading ...

Research Terms

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KATARZYNA CHAWARSKA

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$748,230

FY 2026

Project Title

Investigation into the role of value learning in core features of autism in toddlers

Grant Number:

5R01MH138421-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT. Limited selective social attention represents one of the best-replicated biomarkers in ASD. The mechanisms underlying differences in social attention in ASD remain to be identified. One of the mechanisms that contributes to attentional selection in neurotypical individuals is value learnin...

Research Terms

<0-11 years old><ASD><Affect><Affective><Age><Attention><Attenuated><Autism><Autistic Disorder><Awareness><Behavioral><Biological><Biological Markers><Child><Child Youth><Children (0-21)><Chronology><Cognition><Cognitive><Conscious><Consciousness><Detection><Development><Developmental Delay><Developmental Delay Disorders><Diagnosis><Early Infantile Autism><Encapsulated><Exhibits><Face><Fractals><Individual><Individual Differences><Infantile Autism><Investigation><Kanner's Syndrome><Leanness><Learning><Life><Measures><Modeling><Nature><Neural Development><Pattern><Process><Role><Sampling><Severities><Smiling><Social Behavior><Social Development><Specific Child Development Disorders><Stimulus><Symptoms><System><Testing><Thinness><Time><Toddler><ages><attentional bias><attenuate><attenuates><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic children><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><bio-markers><biologic><biologic marker><biomarker><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><computer based prediction><developmental><experience><eye tracking><faces><facial><gaze><indexing><kids><neural circuit><neural circuitry><neurocircuitry><neurodevelopment><novel><predictive modeling><prospective><reinforcer><repetitive behavior><response><selective attention><sex><social><social attention><social cognition><social role><sociobehavior><sociobehavioral><synaptic circuit><synaptic circuitry><visual discrimination><visual tracking><youngster>

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Gabrielle Rudenko

UNIVERSITY OF TEXAS MED BR GALVESTON, GALVESTON, TX

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$737,907

FY 2026

Project Title

Synaptic Organizers: Dynamic Regulation of Trans-synaptic Bridges

Grant Number:

5R01MH077303-19

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2006

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Synaptic organizers form macromolecular bridges that span the cleft of synapses, the contact and communication points between neurons. Defects in many different synaptic organizers are implicated in neuropsychiatric disorders like schizophrenia (SZ), autism spectrum disorder (ASD), a...

Research Terms

<3-D><3-D structure><3-Dimensional><3-dimensional structure><3D><3D structure><ASD><Address><Adhesives><Animal Model><Animal Models and Related Studies><Assay><Astrocytes><Astrocytus><Astroglia><Autism><Autistic Disorder><Behavior><Binding><Bioassay><Biochemical><Biochemistry><Biological><Biological Assay><Biological Chemistry><Biophysics><CNS Diseases><CNS disorder><Cell Body><Cells><Central Nervous System Diseases><Central Nervous System Disorders><Code><Coding System><Cognition><Communication><Defect><Development><Disease><Disorder><Drugs><Early Infantile Autism><Family><Family member><Filamentous Fungi><Foundations><Funding><Genetic><Goals><Health><Human><Image><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Kanner's Syndrome><Lesion><Ligands><MAST9><Mediating><Medication><Methodology><Modeling><Modern Man><Molds><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Nature><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Pathology><Pharmaceutical Preparations><Play><Position><Positioning Attribute><Process><Protein Conformation><Proteins><Regulation><Role><Schizophrenia><Schizophrenic Disorders><Shapes><Synapses><Synaptic><Synaptic Cleft><Synaptic Membranes><Techniques><Therapeutic><Translating><Work><astrocytic glia><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><base><bases><biologic><biophysical foundation><biophysical principles><biophysical sciences><chronic mental illness><conformation><conformational><conformational state><conformationally><conformations><dementia praecox><developmental><drug/agent><electron tomography><flexibility><flexible><hevin><imaging><in vivo><innovate><innovation><innovative><insight><intellectual and developmental disability><limited intellectual functioning><model of animal><neural circuit><neural circuitry><neurocircuitry><neurological disease><neuronal><neuropsychiatric disease><neuropsychiatric disorder><persistent mental illness><postsynaptic><presynaptic><prototype><public health relevance><recruit><scaffold><scaffolding><schizophrenic><serious mental disorder><serious mental illness><severe mental disorder><severe mental illness><social role><structural biology><synapse><synapse formation><synapse function><synaptic circuit><synaptic circuitry><synaptic function><synaptogenesis><synergism><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><three dimensional><three dimensional structure>

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Kristen Padilla

UNIVERSITY OF TEXAS AT AUSTIN, AUSTIN, TX

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$696,981

FY 2026

Project Title

Identifying and Distinguishing Early indicators of Autism in Latino children (IDEAL)

Grant Number:

5R01DC022420-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Current prevalence rates from the Centers for Disease Control and Prevention indicate that 1 in 36 children have an autism spectrum disorder (autism). When considering the United States population, we find that approximately 26% of children are Latino. However, research on a...

Research Terms

<0-11 years old><1 year of age><1 year old><2 year old><2 years of age><3 year old><3 years of age><5 year old><5 years of age><ASD><Address><Autism><Autistic Disorder><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Child><Child Language><Child Youth><Childhood><Children (0-21)><Clinical><Clinical assessments><Communication><Communities><Cross Sectional Analysis><Data><Development><Developmental Delay><Developmental Delay Disorders><Diagnosis><Disparities><Disparity><Early Infantile Autism><Early Intervention><Early identification><English Language><Environment><Equipment and supply inventories><Espanol><Face><Family><Home><Household><Infantile Autism><Inventory><Kanner's Syndrome><Knowledge><Language><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Linguistic><Linguistics><Measures><Methods><Multilingualism><Nursery Schools><Outcome><Parents><Participant><Personal Satisfaction><Play><Population><Population Heterogeneity><Practice Guidelines><Prevalence><QOL><Quality of life><Recommendation><Reporting><Research><Role><Services><Siblings><Spanish><Spanish/English><Specific Child Development Disorders><Structure><Symptoms><Therapeutic><Time><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Visit><Work><age 1><age 1 year><age 2><age 2 years><age 3><age 3 years><age 5><age 5 years><aged 1 year><aged 2 years><aged one year><aged two years><autism attributes><autism diagnostic observation schedule><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic children><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><bilingual><bilingualism><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical diagnostics><cohort><comparator group><comparison group><design><designing><developmental><diagnostic criteria><diverse populations><early childhood><early screening><ethnic diversity><ethnically diverse><experience><faces><facial><five year old><five years of age><heterogeneous population><homes><indicated prevention><indicated preventive interventions><indicated preventive measure><innovate><innovation><innovative><kids><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><medical diagnostic><multilingual><one year of age><one year old><parent><pediatric><peer><population diversity><pre-k><pre-kindergarten><preschool><prevention directed at individuals><recommended screening><research study><screening guidelines><screening recommendations><service intervention><skills><social role><symptomatology><three year old><three years of age><two year old><two years of age><well-being><wellbeing><youngster>

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Sandra Vanegas

UNIVERSITY OF TEXAS AT AUSTIN, AUSTIN, TX

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$696,981

FY 2026

Project Title

Identifying and Distinguishing Early indicators of Autism in Latino children (IDEAL)

Grant Number:

5R01DC022420-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Current prevalence rates from the Centers for Disease Control and Prevention indicate that 1 in 36 children have an autism spectrum disorder (autism). When considering the United States population, we find that approximately 26% of children are Latino. However, research on a...

Research Terms

<0-11 years old><1 year of age><1 year old><2 year old><2 years of age><3 year old><3 years of age><5 year old><5 years of age><ASD><Address><Autism><Autistic Disorder><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Child><Child Language><Child Youth><Childhood><Children (0-21)><Clinical><Clinical assessments><Communication><Communities><Cross Sectional Analysis><Data><Development><Developmental Delay><Developmental Delay Disorders><Diagnosis><Disparities><Disparity><Early Infantile Autism><Early Intervention><Early identification><English Language><Environment><Equipment and supply inventories><Espanol><Face><Family><Home><Household><Infantile Autism><Inventory><Kanner's Syndrome><Knowledge><Language><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Linguistic><Linguistics><Measures><Methods><Multilingualism><Nursery Schools><Outcome><Parents><Participant><Personal Satisfaction><Play><Population><Population Heterogeneity><Practice Guidelines><Prevalence><QOL><Quality of life><Recommendation><Reporting><Research><Role><Services><Siblings><Spanish><Spanish/English><Specific Child Development Disorders><Structure><Symptoms><Therapeutic><Time><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Visit><Work><age 1><age 1 year><age 2><age 2 years><age 3><age 3 years><age 5><age 5 years><aged 1 year><aged 2 years><aged one year><aged two years><autism attributes><autism diagnostic observation schedule><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic children><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><bilingual><bilingualism><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical diagnostics><cohort><comparator group><comparison group><design><designing><developmental><diagnostic criteria><diverse populations><early childhood><early screening><ethnic diversity><ethnically diverse><experience><faces><facial><five year old><five years of age><heterogeneous population><homes><indicated prevention><indicated preventive interventions><indicated preventive measure><innovate><innovation><innovative><kids><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><medical diagnostic><multilingual><one year of age><one year old><parent><pediatric><peer><population diversity><pre-k><pre-kindergarten><preschool><prevention directed at individuals><recommended screening><research study><screening guidelines><screening recommendations><service intervention><skills><social role><symptomatology><three year old><three years of age><two year old><two years of age><well-being><wellbeing><youngster>

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Carly Demopoulos

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$696,611

FY 2026

Project Title

Phenotyping the neural basis of sensorimotor control of speech in 16p11.2 deletion syndrome

Grant Number:

5R01DC021711-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Deficits in speech production are highly prevalent in neurodevelopmental disorders (NDDs). They are some of the most debilitating of all deficits because they impair communication and there are not effective and efficient substitutes for speaking. In order to build our mechanistic un...

Research Terms

<16p11.2><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><ASD><Affect><Age><Aminalon><Aminalone><Animals><Area><Auditory><Autism><Autistic Disorder><Behavioral><Behavioral Mechanisms><Communication><Communication Disorders><Communication impairment><Communicative Disorders><Compensation><Copy Number Polymorphism><Cross-Sectional Studies><Cross-Sectional Survey><Data><Detection><Development><Disease Frequency Surveys><Dysfunction><Early Infantile Autism><Epilepsy><Epileptic Seizures><Epileptics><Equilibrium><Feedback><Functional disorder><GABA><Genetic><Glutamates><Goals><Human><Impairment><Individual><Infantile Autism><Intervention><Investigators><Kanner's Syndrome><Knowledge><L-Glutamate><Language><MEG imaging><Magnetoencephalography><Maps><Measures><Mechanisms of Behavior and Behavior Change><Methods><Modern Man><Motor Cortex><Nerve Transmitter Substances><Neurobiology><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Dysfunction><Neuropsychologies><Neuropsychology><Neurotransmitters><Participant><Pathway interactions><Phenotype><Physiopathology><Population><Process><Production><Publishing><Research><Research Personnel><Researchers><Seizure Disorder><Sensory><Source><Speech><Symptoms><Syndrome><Time><Update><Voice><Work><accurate speech><ages><autism spectral disorder><autism spectrum disorder><autistic><autistic individuals><autistic people><autistic spectrum disorder><balance><balance function><barrier to care><barrier to health care><barrier to treatment><behavior mechanism><comparator group><comparison group><copy number variant><copy number variation><cross-sectional research study><developmental><epilepsia><epileptogenic><gamma-Aminobutyric Acid><genetic etiology><genetic mechanism of disease><glutamatergic><indexing><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><magnetoencephalogram><magnetoencephalographic imaging><motor control><motor disease><motor disorder><motor dysfunction><motor impairment><movement impairment><movement limitation><multidisciplinary><neural><neural dysfunction><neural mechanism><neurobiological><neurodevelopmental disease><neuromechanism><neuropsychologic><novel><obstacle to care><obstacle to health care><participant enrollment><pathophysiology><pathway><patient enrollment><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><response><sensory feedback><skills><speech accuracy><γ-Aminobutyric Acid>

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John Francis Houde

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$696,611

FY 2026

Project Title

Phenotyping the neural basis of sensorimotor control of speech in 16p11.2 deletion syndrome

Grant Number:

5R01DC021711-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Deficits in speech production are highly prevalent in neurodevelopmental disorders (NDDs). They are some of the most debilitating of all deficits because they impair communication and there are not effective and efficient substitutes for speaking. In order to build our mechanistic un...

Research Terms

<16p11.2><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><ASD><Affect><Age><Aminalon><Aminalone><Animals><Area><Auditory><Autism><Autistic Disorder><Behavioral><Behavioral Mechanisms><Communication><Communication Disorders><Communication impairment><Communicative Disorders><Compensation><Copy Number Polymorphism><Cross-Sectional Studies><Cross-Sectional Survey><Data><Detection><Development><Disease Frequency Surveys><Dysfunction><Early Infantile Autism><Epilepsy><Epileptic Seizures><Epileptics><Equilibrium><Feedback><Functional disorder><GABA><Genetic><Glutamates><Goals><Human><Impairment><Individual><Infantile Autism><Intervention><Investigators><Kanner's Syndrome><Knowledge><L-Glutamate><Language><MEG imaging><Magnetoencephalography><Maps><Measures><Mechanisms of Behavior and Behavior Change><Methods><Modern Man><Motor Cortex><Nerve Transmitter Substances><Neurobiology><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Dysfunction><Neuropsychologies><Neuropsychology><Neurotransmitters><Participant><Pathway interactions><Phenotype><Physiopathology><Population><Process><Production><Publishing><Research><Research Personnel><Researchers><Seizure Disorder><Sensory><Source><Speech><Symptoms><Syndrome><Time><Update><Voice><Work><accurate speech><ages><autism spectral disorder><autism spectrum disorder><autistic><autistic individuals><autistic people><autistic spectrum disorder><balance><balance function><barrier to care><barrier to health care><barrier to treatment><behavior mechanism><comparator group><comparison group><copy number variant><copy number variation><cross-sectional research study><developmental><epilepsia><epileptogenic><gamma-Aminobutyric Acid><genetic etiology><genetic mechanism of disease><glutamatergic><indexing><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><magnetoencephalogram><magnetoencephalographic imaging><motor control><motor disease><motor disorder><motor dysfunction><motor impairment><movement impairment><movement limitation><multidisciplinary><neural><neural dysfunction><neural mechanism><neurobiological><neurodevelopmental disease><neuromechanism><neuropsychologic><novel><obstacle to care><obstacle to health care><participant enrollment><pathophysiology><pathway><patient enrollment><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><response><sensory feedback><skills><speech accuracy><γ-Aminobutyric Acid>

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SRIKANTAN S. NAGARAJAN

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$696,611

FY 2026

Project Title

Phenotyping the neural basis of sensorimotor control of speech in 16p11.2 deletion syndrome

Grant Number:

5R01DC021711-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Deficits in speech production are highly prevalent in neurodevelopmental disorders (NDDs). They are some of the most debilitating of all deficits because they impair communication and there are not effective and efficient substitutes for speaking. In order to build our mechanistic un...

Research Terms

<16p11.2><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><ASD><Affect><Age><Aminalon><Aminalone><Animals><Area><Auditory><Autism><Autistic Disorder><Behavioral><Behavioral Mechanisms><Communication><Communication Disorders><Communication impairment><Communicative Disorders><Compensation><Copy Number Polymorphism><Cross-Sectional Studies><Cross-Sectional Survey><Data><Detection><Development><Disease Frequency Surveys><Dysfunction><Early Infantile Autism><Epilepsy><Epileptic Seizures><Epileptics><Equilibrium><Feedback><Functional disorder><GABA><Genetic><Glutamates><Goals><Human><Impairment><Individual><Infantile Autism><Intervention><Investigators><Kanner's Syndrome><Knowledge><L-Glutamate><Language><MEG imaging><Magnetoencephalography><Maps><Measures><Mechanisms of Behavior and Behavior Change><Methods><Modern Man><Motor Cortex><Nerve Transmitter Substances><Neurobiology><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Dysfunction><Neuropsychologies><Neuropsychology><Neurotransmitters><Participant><Pathway interactions><Phenotype><Physiopathology><Population><Process><Production><Publishing><Research><Research Personnel><Researchers><Seizure Disorder><Sensory><Source><Speech><Symptoms><Syndrome><Time><Update><Voice><Work><accurate speech><ages><autism spectral disorder><autism spectrum disorder><autistic><autistic individuals><autistic people><autistic spectrum disorder><balance><balance function><barrier to care><barrier to health care><barrier to treatment><behavior mechanism><comparator group><comparison group><copy number variant><copy number variation><cross-sectional research study><developmental><epilepsia><epileptogenic><gamma-Aminobutyric Acid><genetic etiology><genetic mechanism of disease><glutamatergic><indexing><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><magnetoencephalogram><magnetoencephalographic imaging><motor control><motor disease><motor disorder><motor dysfunction><motor impairment><movement impairment><movement limitation><multidisciplinary><neural><neural dysfunction><neural mechanism><neurobiological><neurodevelopmental disease><neuromechanism><neuropsychologic><novel><obstacle to care><obstacle to health care><participant enrollment><pathophysiology><pathway><patient enrollment><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><response><sensory feedback><skills><speech accuracy><γ-Aminobutyric Acid>

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Lucina Qazi Uddin

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$676,978

FY 2026

Project Title

Longitudinal investigation of bilingualism, executive function, and brain organization in autism

Grant Number:

5R01HD116691-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Autism spectrum disorder (ASD) is associated with marked heterogeneity with respect to the development of executive function (EF) abilities. In the United States, 12 million children primarily speak a language other than English in the home, suggesting that 1 in 4 children with ASD a...

Research Terms

<0-11 years old><12 year old><12 years of age><16 year old><16 years of age><8 year old><8 years of age><ASD><Active Follow-up><Address><Affect><Age><Aging><Amentia><Attention><Autism><Autistic Disorder><Behavior><Behavioral><Brain><Brain Nervous System><Buffers><Child><Child Development Disorders><Child Language><Child Youth><Children (0-21)><Clinical><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><DWI (diffusion weighted imaging)><DWI-MRI><Data><Dementia><Development><Developmental Disabilities><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Dimensions><Disease><Disorder><Disturbance in cognition><Early Infantile Autism><Encephalon><Enrollment><Environment><Equipment and supply inventories><Exhibits><Family><Functional MRI><Functional Magnetic Resonance Imaging><Heterogeneity><Home><Immediate Memory><Impaired cognition><Impairment><Individual><Infantile Autism><Intervention><Inventory><Kanner's Syndrome><Laboratories><Language><Language Development><Lateral><Literature><Los Angeles><NIH><National Institutes of Health><Neurocognitive><Neurodevelopmental Disorder><Neurological Development Disorder><Neurosciences Research><Performance><Population><Puberty><QOL improvement><Recommendation><Reporting><Research><Rest><Severities><Short-Term Memory><Social Development><Social Support System><Socio-economic status><Socioeconomic Status><Sorting><Strategic Planning><Support System><Testing><Time><United States><United States National Institutes of Health><acquiring language skills><active followup><age 12><age 12 years><age 16><age 16 years><age 8><age 8 years><ages><autism spectral disorder><autism spectrum disorder><autistic children><autistic individuals><autistic people><autistic spectrum disorder><bilingual><bilingualism><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cognitive ability><cognitive development><cognitive dysfunction><cognitive enhancement><cognitive loss><cognitive neuroscience><cognitive task><critical period><dMRI><developmental><diffusion tensor imaging><early adolescence><eight year old><eight years of age><endophenotype><enroll><executive control><executive function><experience><fMRI><flexibility><flexible><follow up><follow-up><followed up><followup><homes><improvements in QOL><improvements in quality of life><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><informant><insight><investigate longitudinal><kids><language acquisition><language learning><longitudinal investigation><longitudinal research><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><multi-modal neuro-imaging><multimodal neuroimaging><neural><neurodevelopmental disease><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><quality of life improvement><sex><sixteen year old><sixteen years of age><socio-economic position><socioeconomic position><study longitudinal><substantia alba><support network><survey longitudinal><twelve year old><twelve years of age><verbal><white matter><working memory><youngster>

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Molly C Losh

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$675,624

FY 2026

Project Title

Defining the female pragmatic language profile of autism and the broad autism phenotype

Grant Number:

5R01DC022484-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/8/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary Pragmatic (i.e., social) language impairments are a defining feature of autism spectrum disorder (ASD), which can impose significant burden on individuals throughout the lifespan. Strong evidence also suggests that this clinical domain is influenced by genetic markers associated with ASD in ...

Research Terms

<0-11 years old><1st degree relative><ASD><Address><Age><Anxiety><Autism><Autistic Disorder><Behavior><Behavioral><Causality><Characteristics><Child><Child Youth><Children (0-21)><Classification><Clinical><Code><Coding System><Complement><Complement Proteins><Complex><Control Groups><Data><Detection><Development><Diagnosis><Diagnostic><Differences between sexes><Differs between sexes><Early Infantile Autism><Etiology><Family Study><Fathers><Female><First Degree Relative><Future><General Population><General Public><Genes><Genetic><Genetic Markers><Grain><Hand><Heterogeneity><Incidence><Individual><Infantile Autism><Internet><Intervention><Kanner's Syndrome><Language><Link><Literature><Machine Learning><Measures><Mediating><Methods><Mothers><Neurocognitive><Neuropsychologies><Neuropsychology><Outcome><Parents><Pattern><Personal Satisfaction><Phenotype><Play><QOL><Quality of life><Research><Research Design><Role><Sampling><Services><Sex Differences><Sexual differences><Social Characteristics><Social Environment><Social Functioning><Source><Study Type><Symptoms><System><Systematics><Testing><Transmission><Vocation><WWW><Work><ages><analytical tool><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic><autistic children><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><causation><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical phenotype><cohort><comparator group><comparison group><complementation><crowd source><crowd-sourcing><crowdsource><crowdsourcing><developmental><differential expression><differentially expressed><disease causation><emerging adulthood><executive control><executive function><family focused study><family survey><function socially><functioning social><gene biomarker><gene expression biomarker><gene marker><gene signature biomarker><genetic biomarker><hands><improved><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><insight><instrument><intergenerational><kids><language ability><language impairment><language skills><life span><lifespan><machine based learning><male><neuropsychologic><parent><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><pragmatic study><predict clinical outcome><psychosocial><psychosocial outcome><psychosocial sequelae><sex><sex based differences><sex dependent trait><sex linked trait><sex related characteristic><sex related trait><sex specific characteristic><sex specific trait><sex trait><sex-dependent differences><sex-related differences><sex-specific differences><skills><social><social climate><social cognition><social communication><social context><social role><socioenvironment><socioenvironmental><study design><success><trait><transcriptional differences><translational goal><translational mission><transmission process><virtual><web><well-being><wellbeing><world wide web><youngster><♀><♂>

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Gary Everett Martin

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$675,624

FY 2026

Project Title

Defining the female pragmatic language profile of autism and the broad autism phenotype

Grant Number:

5R01DC022484-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/8/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary Pragmatic (i.e., social) language impairments are a defining feature of autism spectrum disorder (ASD), which can impose significant burden on individuals throughout the lifespan. Strong evidence also suggests that this clinical domain is influenced by genetic markers associated with ASD in ...

Research Terms

<0-11 years old><1st degree relative><ASD><Address><Age><Anxiety><Autism><Autistic Disorder><Behavior><Behavioral><Causality><Characteristics><Child><Child Youth><Children (0-21)><Classification><Clinical><Code><Coding System><Complement><Complement Proteins><Complex><Control Groups><Data><Detection><Development><Diagnosis><Diagnostic><Differences between sexes><Differs between sexes><Early Infantile Autism><Etiology><Family Study><Fathers><Female><First Degree Relative><Future><General Population><General Public><Genes><Genetic><Genetic Markers><Grain><Hand><Heterogeneity><Incidence><Individual><Infantile Autism><Internet><Intervention><Kanner's Syndrome><Language><Link><Literature><Machine Learning><Measures><Mediating><Methods><Mothers><Neurocognitive><Neuropsychologies><Neuropsychology><Outcome><Parents><Pattern><Personal Satisfaction><Phenotype><Play><QOL><Quality of life><Research><Research Design><Role><Sampling><Services><Sex Differences><Sexual differences><Social Characteristics><Social Environment><Social Functioning><Source><Study Type><Symptoms><System><Systematics><Testing><Transmission><Vocation><WWW><Work><ages><analytical tool><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic><autistic children><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><causation><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical phenotype><cohort><comparator group><comparison group><complementation><crowd source><crowd-sourcing><crowdsource><crowdsourcing><developmental><differential expression><differentially expressed><disease causation><emerging adulthood><executive control><executive function><family focused study><family survey><function socially><functioning social><gene biomarker><gene expression biomarker><gene marker><gene signature biomarker><genetic biomarker><hands><improved><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><insight><instrument><intergenerational><kids><language ability><language impairment><language skills><life span><lifespan><machine based learning><male><neuropsychologic><parent><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><pragmatic study><predict clinical outcome><psychosocial><psychosocial outcome><psychosocial sequelae><sex><sex based differences><sex dependent trait><sex linked trait><sex related characteristic><sex related trait><sex specific characteristic><sex specific trait><sex trait><sex-dependent differences><sex-related differences><sex-specific differences><skills><social><social climate><social cognition><social communication><social context><social role><socioenvironment><socioenvironmental><study design><success><trait><transcriptional differences><translational goal><translational mission><transmission process><virtual><web><well-being><wellbeing><world wide web><youngster><♀><♂>

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Craig M Powell

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$659,549

FY 2026

Project Title

Functional Studies of NDD Gene(s)

Grant Number:

5R01MH135954-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/13/2025

End Date:

10/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Neurodevelopmental disorders are common, debilitating disorders including autism, intellectual disability, and perhaps even schizophrenia. Recent genetic findings have identified mutations in multiple genes in various cellular pathways as genetic causes of rare neurodevelop...

Research Terms

<21+ years old><ASD><Adult><Adult Human><Affect><Ammon Horn><Animal Genetics><Animal Model><Animal Models and Related Studies><Area><Assay><Atlases><Autism><Autistic Disorder><Awareness><Behavior><Behavioral><Behavioral Symptoms><Bioassay><Biological Assay><Body Tissues><Brachydanio rerio><Brain><Brain Nervous System><Brain region><Breeding><Budgets><CaM KII><CaM PK II><CaM kinase II><CaMKII><Cell Body><Cell Cycle><Cell Division Cycle><Cell Growth in Number><Cell Multiplication><Cell Nucleus><Cell Proliferation><Cells><Cellular Proliferation><Chromatin><Complement><Complement Proteins><Cornu Ammonis><DNA mutation><Danio rerio><Data><Data Set><Development><Disease><Disorder><Drug Therapy><Dysfunction><EC 2.1.1><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Embryo><Embryonic><Encephalon><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Functional disorder><Funding><Future><Gene Expression><Generalized Growth><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Glia><Glial Cells><Growth><Heterogeneity><Hippocampus><Human><Human Genetics><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><KO mice><Kanner's Syndrome><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Kolliker's reticulum><L-Lysine><Laboratories><Learning><Link><Lysine><MR Imaging><MR Tomography><MRI><MRIs><Macrocephaly><Magnetic Resonance Imaging><Male Sterility><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Megacephaly><Megalocephaly><Memory><Methylation><Methyltransferase><Mice><Mice Mammals><Mitotic><Modeling><Modern Man><Molecular><Morphology><Murine><Mus><Mutation><NMR Imaging><NMR Tomography><Nerve Cells><Nerve Unit><Network Analysis><Neural Cell><Neural Development><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurological Development Disorder><Neurons><Neurophysiology / Electrophysiology><Non-neuronal cell><Nonneuronal cell><Nuclear Magnetic Resonance Imaging><Nucleus><Null Mouse><Ontology><Outcome Measure><Paper><Pathway Analysis><Pathway interactions><Patients><Pharmacological Treatment><Pharmacotherapy><Physiopathology><Prefrontal Cortex><Proteins><Publishing><Resolution><Role><Schizophrenia><Schizophrenic Disorders><Single-Nucleus Sequencing><Slice><Synapses><Synaptic><Syndrome><Techniques><Testing><Therapeutic><Time><Tissue Growth><Tissues><Transposase><Work><Zebra Danio><Zebra Fish><Zebrafish><Zeugmatography><adulthood><autism model><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior outcome><behavior study><behavioral outcome><behavioral study><brain cell><brain size><calcium-dependent CaM kinase II><calmodulin-dependent protein kinase II><cell type><chromatin modification><complementation><dementia praecox><developmental><differential expression><differentially expressed><drug intervention><drug treatment><electrophysiological><experience><experiment><experimental research><experimental study><experiments><genome mutation><genome scale><genome-wide><genomewide><hippocampal><intellectual and developmental disability><interest><limited intellectual functioning><loss of function><loss of function mutation><mRNA Expression><measurable outcome><methylase><model of animal><model of autism spectrum disorder><mouse model><multi-modality><multimodality><multiomics><multiple omics><murine model><mutant><nerve cement><neurodevelopment><neurodevelopmental disease><neurogenesis><neuronal><novel><ontogeny><outcome measurement><panomics><pathophysiology><pathway><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><rare condition><rare syndrome><resolutions><sNuc-Seq><schizophrenic><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social><social role><synapse><synapse function><synaptic function><transcriptional differences><transmethylase>

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Harrison W Gabel

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$655,201

FY 2026

Project Title

MECHANISMS OF EPIGENETIC REGULATION IN NERVOUS SYSTEM DEVELOPMENT

Grant Number:

5R01MH117405-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/14/2019

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY With the identification of hundreds of genes associated with autism spectrum and related neurodevelopmental disorders (ASD/NDD), there is a pressing need to define the molecular pathways these genes contribute to in the nervous system and to dissect how their disruption alters brain ...

Research Terms

<0-11 years old><3'-5'-CpG><ASD><ASH1L><ASH1L gene><Address><Autism><Autistic Disorder><Binding><Biology><Brain><Brain Nervous System><CG-dinucleotide><Causality><Cell Body><Cells><Cerebroatrophic Hyperammonemia><Child><Child Youth><Children (0-21)><CpG dinucleotide><Cytosine><DNA><DNA Methylation><DNA methyltransferase 3 alpha mutation><DNA mutation><DNMT3a><DNMT3a mutation><Deoxyribonucleic Acid><Deposit><Deposition><Diagnosis><Dinucleoside Phosphates><Disease><Disorder><Dysfunction><EC 2.1.1><Early Infantile Autism><Encephalon><Enhancers><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Functional disorder><Future><Gene Alteration><Gene Down-Regulation><Gene Expression><Gene Mutation><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genomics><Glia><Glial Cells><Goals><Grant><Histone H3><Histones><Infantile Autism><Kanner's Syndrome><Kolliker's reticulum><L-Lysine><Lesion><Lysine><Mammalian Cell><MeCP-2 protein><MeCP2><MeCP2 protein><Methyl CpG binding protein MeCP2><Methyl-CpG-Binding Protein 2><Methyl-DNA binding protein MECP2><Methylation><Methyltransferase><Modification><Molecular><Molecular Interaction><Mutant Strains Mice><Mutate><Mutation><Nerve Cells><Nerve Unit><Nervous System><Nervous System Physiology><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurologic Body System><Neurologic Organ System><Neurologic function><Neurological Development Disorder><Neurological function><Neuronal Dysfunction><Neurons><Non-neuronal cell><Nonneuronal cell><Output><Pathway interactions><Pattern><Phenotype><Physiopathology><Play><Predisposition><Property><Proteins><Publishing><RNA Expression><Regulation><Resolution><Rett Disorder><Rett Syndrome><Role><Site><Structure><Susceptibility><System><Technology><Testing><Transcription><Transcription Repression><Transcriptional Control><Transcriptional Regulation><Work><analysis pipeline><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><causation><cell type><cytidine monophosphate guanosine><cytidylyl-3'-5'-guanosine><cytosine-guanine dinucleotide><dinucleotide><disease causation><epigenetic regulation><epigenetically><epigenome profiling><epigenomic profiling><epigenomics><gene defect><gene repression><genome mutation><global gene expression><global transcription profile><hDNA methyltransferase 3a><in vivo><innovate><innovation><innovative><insight><kids><methylase><methylation pattern><mouse mutant><mutant allele><nerve cement><nervous system development><nervous system function><neural dysfunction><neurodevelopmental disease><neuronal><neuronal patterning><pathophysiology><pathway><programs><resolutions><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><therapeutic agent development><therapeutic development><transcriptome><transcriptomics><transmethylase><youngster>

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YUH NUNG JAN

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$627,979

FY 2026

Project Title

Dendrite development, function, degeneration and regeneration

Grant Number:

5R35NS137312-02

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2024

End Date:

11/30/2032

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Since 2002, a major focus of our lab has been dendrite development. Dendrite arborization patterns are critical components of neural circuits; they influence the synaptic or sensory inputs a neuron receives. Back in 2002, little was known about the molecular mechanisms that ...

Research Terms

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Rujuta Bhatt Wilson

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$625,859

FY 2026

Project Title

Predicting ASD Outcomes Using Quantitative Movement Metrics in Infancy

Grant Number:

1R01NS142720-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/27/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Abstract Motor impairments are one of the first signs of atypical development in infants who go on to have autism spectrum disorder (ASD) and are more closely tied to abnormal neurobiological processes in ASD. Motor behavior has high potential to serve as a measurable early behavioral differ...

Research Terms

<2 year old><2 years of age><4 year old><4 years of age><ASD><Address><Age><Age Months><Area><Autism><Autistic Disorder><Behavior><Behavior Disorders><Behavior assessment><Behavioral><Bilateral><Biological Markers><Birth><Brain><Brain Nervous System><Caring><Characteristics><Child Development><Childhood><Chronologic Fetal Maturity><Classification><Clinical><Clinical assessments><Cluster Analyses><Cluster Analysis><Complex><Computational Technique><Data><Detection><Development><Developmental Delay><Developmental Delay Disorders><Diagnosis><Diagnostic><Dimensions><Early Diagnosis><Early Infantile Autism><Early Intervention><Early identification><Encephalon><Enrollment><Environmental Factor><Environmental Risk Factor><Exhibits><Fetal Age><Gestational Age><Goals><Home><Hour><Infant><Infant and Child Development><Infantile Autism><Kanner's Syndrome><Language><Lead><Life><Lower Extremity><Lower Limb><Machine Learning><Measurable><Measures><Membrum inferius><Membrum superius><Methods><Modeling><Motor><Movement><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nature><Neurobiology><Outcome><Parturition><Pattern><Pb element><Performance><Process><Research Priority><Rural Population><Rural group><Rural people><Siblings><Socio-economic status><Socioeconomic Status><Specific Child Development Disorders><Standardization><Systematics><Techniques><Theoretic Models><Theoretical model><Time><Underserved Population><Upper Extremity><Upper Limb><Validation><Well Child Visits><Well child checks><Well child checkups><Well child exam><Work><age 2><age 2 years><age 4><age 4 years><aged 2 years><aged two years><ages><autism attributes><autism biomarker><autism indicator><autism marker><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><behavior measurement><behavioral assessment><behavioral disorder><behavioral measure><behavioral measurement><bio-markers><biologic marker><biomarker><body movement><body sensor><body worn sensor><child routine wellness visits><child wellness visit><cognitive process><cohort><computer based prediction><developmental><developmental disease><developmental disorder><diagnostic criteria><early detection><effective intervention><enroll><environmental risk><four year old><four years of age><functional outcomes><heavy metal Pb><heavy metal lead><homes><improved><improved outcome><infancy><infantile><investigate longitudinal><longitudinal investigation><longitudinal research><machine based learning><machine learning based method><machine learning method><machine learning methodologies><motor behavior><motor impairment><movement impairment><movement limitation><neurobiological><novel><pediatric><pediatric preventive visit><pediatric well visit><predictive biological marker><predictive biomarkers><predictive marker><predictive modeling><predictive molecular biomarker><prospective><routine child health visit><rural individual><screening><screenings><sensing data><sensor><sensor data><signal processing><social communication><socio-economic position><socioeconomic position><study longitudinal><survey longitudinal><theories><two year old><two years of age><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><validations><wearable biosensor><wearable sensor><wearable sensor technology>

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GRAEME W DAVIS

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$621,082

FY 2026

Project Title

Presynaptic Homeostatic Plasticity and Mental Health

Grant Number:

5R01MH134827-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/18/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Homeostatic plasticity (HP) encompasses a suite of compensatory physiological processes that stabilize neural function. It is widely hypothesized that homeostatic plasticity will be linked to the cause and/or severity of mental health disorders including autism and intellectual disability. ...

Research Terms

<21+ years old><A5 Antigen><AMPA Receptors><ASD><Acute><Adult><Adult Human><Ammon Horn><Area><Assay><Autism><Autistic Disorder><Bioassay><Biological Assay><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Causality><Cell Communication and Signaling><Cell Signaling><Chemosensitization><Chemosensitization/Potentiation><Complex><Cornu Ammonis><DNA mutation><Data><Development><Disease><Disorder><Drosophila><Drosophila genus><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Encephalon Diseases><Environmental Factor><Environmental Risk Factor><Epilepsy><Epileptic Seizures><Epileptics><Equilibrium><Etiology><Excitatory Synapse><Future><Genes><Genetic><Genetic Change><Genetic Screening><Genetic defect><Genetic mutation><Grant><Hippocampus><Human><Impairment><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knock-out><Knockout><Knowledge><Laboratories><Life><Link><Maintenance><Mediating><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mice><Mice Mammals><Modality><Modern Man><Molecular><Murine><Mus><Mutant Strains Mice><Mutation><NRP1 Protein><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Transmission><Neurocyte><Neurohumor Receptors><Neurologic Disorders><Neurological Disorders><Neuromediator Receptors><Neurons><Neurophysiology - biologic function><Neurophysiology / Electrophysiology><Neuropilin-1><Neuropilins><Neuroregulator Receptors><Neurotransmitter Receptor><Npn-1 Protein><Organism-Level Process><Organismal Process><Outcome><Pathway interactions><Physiologic><Physiologic Processes><Physiological><Physiological Processes><Position><Positioning Attribute><Potentiation><Presynaptic Receptors><Process><Property><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Pyramidal neuron><Receptor Protein><Regulation><Research><Risk Factors><Risk-associated variant><Rodent><Rodentia><Rodents Mammals><Role><Schizophrenia><Schizophrenic Disorders><Seizure Disorder><Sema III Receptor><Semaphorin III Receptor><Semaphorins><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Synapses><Synaptic><Synaptic Transmission><Synaptic Vesicles><System><Therapeutic><Vascular Endothelial Cell Growth Factor 165 Receptor><Work><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><balance><balance function><biological signal transduction><causation><co-morbid><co-morbidity><comorbidity><dementia praecox><developmental><disease causation><electrophysiological><environmental risk><epilepsia><epileptogenic><experiment><experimental research><experimental study><experiments><fruit fly><gene replacement><genome mutation><high risk><hippocampal><hippocampal pyramidal neuron><in vivo><intellectual and developmental disability><limited intellectual functioning><mental illness><mouse mutant><neural circuit><neural circuitry><neural function><neurocircuitry><neurological disease><neuronal><neuronal excitability><neuroprotection><neuroprotective><neurotransmitter release><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><open data><open science><open-source data><pathway><postsynaptic><preservation><presynaptic><prevent><preventing><psychiatric illness><psychological disorder><receptor><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><schizophrenic><social role><synapse><synapse inhibition><synaptic circuit><synaptic circuitry><synaptic inhibition>

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Anthony J Koleske

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$611,974

FY 2026

Project Title

Identification and characterization of chemical probes of TRIO GEF1 activity

Grant Number:

5R01MH132685-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Genetic variants in the TRIO gene increase risk for neurodevelopmental disorders (NDDs) including schizophrenia, autism, and related disorders. A cluster of NDD-associated variants selectively impacts TRIO guanine nucleotide exchange factor domain 1 (GEF1) activity, which activates t...

Research Terms

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Youssef Oulhote

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$582,537

FY 2026

Project Title

The interplay of early life exposure to environmental pollutants and folate system in the etiology of autistic behaviors

Grant Number:

5R01ES032552-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

10/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project summary Autism spectrum disorders (ASD) which are multifactorial complex disorders characterized by communication deficits and repetitive behaviors affect between 1 and 2% of children in the US and Canada. Air pollutants, phthalates, and pesticides are suspected of contributing to the etiolo...

Research Terms

<0-11 years old><1st trimester><3rd trimester><4 year old><4 years of age><ASD><Address><Adult Folate Receptor 1><Adult Folate-Binding Protein><Affect><Air Pollutants><Air Pollution><American><Attenuated><Autism><Autistic Disorder><Autoantibodies><Award><BBB crossing><Birth><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Brain><Brain Nervous System><Canada><Carbon><Causality><Chemical Exposure><Chemically Induced Neurotoxicity><Chemicals><Child><Child Youth><Children (0-21)><Chloroethylene Homopolymer><Chloroethylene Polymer><Cities><Clinical><Communication><Complex><Complex Mixtures><Cytotoxic agent><Cytotoxic drug><Data><Development><Dietary Intervention><Disease><Disorder><Early Infantile Autism><Early Placental Phase><Encephalon><Environmental Exposure><Environmental Pollutants><Ethene, chloro-, homopolymer><Etiology><Europe><Exposure to><FOLR><FOLR1><FOLR1 gene><Family><First Pregnancy Trimester><First Trimester><Folate><Folate Metabolism><Folate Receptor Alpha><Folic Acid><Folic Acid Metabolosm><Fostering><Genes><Genetic><Genetic Polymorphism><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Gestation><Health><High Prevalence><Immune Cell Activation><Individual><Infant><Infantile Autism><Inflammation><Inherited Predisposition><Inherited Susceptibility><Insecticides><Intake><Intermediary Metabolism><Intervention><Investigators><Joints><Kanner's Syndrome><Last Trimester><Life><Link><MOv18><Measurement><Measures><Mediator><Metabolic Processes><Metabolism><Methylene Tetrahydrofolate Reductase><Methylenetetrahydrofolate Reductase><Methylenetetrahydrofolate reductase (NADPH)><Mothers><NO2><Neural Development><Nitrogen Dioxide><Nitrogen Peroxide><North America><Nutrition Interventions><Nutritional><Nutritional Interventions><Organophosphates><Ovarian Cancer-Associated Antigen><Oxidative Stress><PM0.1><Particulate Matter><Parturition><Pesticides><Plasma><Plasma Serum><Plastics><Play><Polychloroethylene><Polyvinyl Chloride><Population><Predisposition><Pregnancy><Pregnancy Trimesters><Pregnant Women><Preventative strategy><Prevention strategy><Preventive strategy><Probabilistic Models><Probability Models><Pteroylglutamic Acid><Public Health><Research><Research Personnel><Researchers><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Role><Scientist><Statistical Models><Susceptibility><System><Testing><Third Pregnancy Trimester><Third Trimester><Time><Ultrafine Particulates><Vinyl Chloride Polymer><Vitamin M><Woman><Work><age 4><age 4 years><attenuate><attenuates><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic behavior><autistic behaviour><autistic children><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like behavior><autistic-like symptoms><autoimmune antibody><autoreactive antibody><biobank><biorepository><blood-brain barrier crossing><bloodbrain barrier crossing><career development><causation><chemical association><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cohort><developmental><diet intervention><disease causation><early life exposure><environmental chemical><environmental contaminant><expectant mother><expectant women><expecting mother><expecting women><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><folate supplementation><folic acid metabolism><folic acid supplement><folic acid supplementation><four year old><four years of age><genetic vulnerability><genetically predisposed><immune activation><individuals who are pregnant><instrument><kids><malleable risk><man><modifiable risk><neurodevelopment><nutritious><particle><people who are pregnant><personal care products><phthalates><pollutant><polymorphism><polyvinylchloride><population based><population health><pregnant females><pregnant mothers><pregnant people><pregnant populations><prevent><preventing><protective effect><repetitive behavior><self reactive antibody><social><social role><statistical linear mixed models><statistical linear models><supplementation with folate><supplementation with folic acid><those who are pregnant><trait><ultrafine particle><ultrafine particulate matter><vinylchloride polymer><vitamin Bc><women who are pregnant><youngster>

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GINA R KUPERBERG

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$575,664

FY 2026

Project Title

The neural basis of language comprehension: Insights from spatiotemporal imaging

Grant Number:

5R01HD082527-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2015

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

For language comprehension to succeed in noisy and ambiguous environments, the human brain must use contextual information to actively predict upcoming linguistic inputs. Impairments in top-down prediction are thought to contribute to language and communicative dysfunction in a variety of neurodevel...

Research Terms

<21+ years old><ASD><Adult><Adult Human><Anterior><Appearance><Autism><Autistic Disorder><Belief><Brain><Brain Nervous System><Code><Coding System><Communication><Communication Disability><Communicative Disability><Communicative Dysfunctions><Computer Models><Computer Simulation><Computer based Simulation><Computerized Models><Cues><Development><Disease><Disorder><Dyslexia><EEG><Early Infantile Autism><Electroencephalogram><Electroencephalography><Encephalon><Environment><Event><Event-Related Potentials><Failure><Feedback><Foundations><Frequencies><Functional MRI><Functional Magnetic Resonance Imaging><Grant><Human><Impairment><Infantile Autism><Inferior><Kanner's Syndrome><Language><Language Disorders><Left><Linguistic><Linguistics><Link><Location><MEG imaging><Magnetoencephalography><Methods><Modeling><Modern Man><Neighborhoods><Neurobiology><Neurocognitive><Neurodevelopmental Disorder><Neurological Development Disorder><Orthography><Phase><Prefrontal Cortex><Prevention><Reading Disabilities><Reading disability><Research><Schizophrenia><Schizophrenic Disorders><Semantics><Sensory><Series><Social Functioning><Stimulus><Techniques><Temporal Lobe><Testing><Word Blindness><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><cognitive function><comprehending language><computational modeling><computational models><computational simulation><computer based models><computerized modeling><computerized simulation><dementia praecox><developmental><event related potential><experiment><experimental research><experimental study><experiments><fMRI><flexibility><flexible><frontal cortex><frontal lobe><function socially><functioning social><insight><language comprehension><language deficit><language processing><lexical><magnetoencephalogram><magnetoencephalographic imaging><multi-modal neuro-imaging><multimodal neuroimaging><neural><neural imaging><neural patterning><neuro-imaging><neurobiological><neurodevelopmental disease><neuroimaging><neurological imaging><neuropsychiatric disease><neuropsychiatric disorder><remediation><response><schizophrenic><semantic processing><sensory input><social defects><social deficits><social disorders><social dysfunction><spatial and temporal><spatial temporal><spatial temporal imaging><spatial temporal mapping><spatiotemporal><spatiotemporal imaging><spatiotemporal mapping><support network><temporal cortex><theories><tool><treatment strategy>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Andrew P Escayg

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$575,485

FY 2026

Project Title

Understanding the contribution of BCL11A to neuron function and neurological disease

Grant Number:

1R01NS146992-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY BCL11A is a zinc-finger transcription factor that has been well-studied in erythroid biology, but evidence for an important role in the brain is beginning to emerge. Patients with heterozygous loss-of-function BCL11A mutations present with clinical features that can include intellect...

Research Terms

<21+ years old><2p15><AD dementia><AD patients><ASD><Adult><Adult Human><Affect><Allelic Loss><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease patient><Alzheimer's patient><Alzheimers Dementia><Autism><Autistic Disorder><Autopsy><Basal Transcription Factor><Basal transcription factor genes><Behavior><Behavioral><Binding><Biology><Brain><Brain Nervous System><Causality><Cell Body><Cell Line><CellLine><Cells><Chromatin><Chromosomal microdeletion><Clinical><Cognitive deficits><Complex><Connector Neuron><Cyclic Somatostatin><DNA mutation><Data><Data Bases><Data Set><Databases><Development><Developmental Delay><Developmental Delay Disorders><Differential Display><Disease><Disorder><Dorsal><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Embryo><Embryonic><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Erythroid><Etiology><Exhibits><Expression Signature><Fore-Brain><Forebrain><Functional disorder><GWA study><GWAS><Gene Expression><Gene Expression Profile><Gene Targeting><General Transcription Factor Gene><General Transcription Factors><Generalized Epilepsy><Generalized Seizure Disorder><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Heterozygote><Histology><Human><Hyperactivity><In Vitro><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Jobs><KO mice><Kanner's Syndrome><Knock-out Mice><Knockout Mice><Link><Loss of Heterozygosity><Meta-Analysis><Methods><Mice><Mice Mammals><Modern Man><Molecular Interaction><Murine><Mus><Mutant Strains Mice><Mutation><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurologic><Neurologic Disorders><Neurological><Neurological Development Disorder><Neurological Disorders><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Null Mouse><Occupations><Organoids><Parvalbumins><Pathologic><Patients><Persons><Phenotype><Physiologic><Physiological><Physiopathology><Play><Population><Predisposition><Prefrontal Cortex><Primary Senile Degenerative Dementia><Professional Positions><Prosencephalon><Regulation><Research><Risk-associated variant><Role><SRIH><SRIH-14><Schizophrenia><Schizophrenic Disorders><Seizure Disorder><Seizures><Series><Single-Nucleus Sequencing><Somatostatin><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><Specific Child Development Disorders><Specific qualifier value><Specified><Strains Cell Lines><Structure><Susceptibility><Syndrome><Testing><Time><Transcription Factor Proto-Oncogene><Transcription factor genes><Translating><Zinc Finger Domain><Zinc Finger Motifs><Zinc Fingers><adulthood><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic people><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><causation><cell type><clinical phenotype><cognitive defects><cultured cell line><data base><dementia praecox><develop therapy><developmental><differential display technique><disease causation><disease phenotype><electrophysiological><epigenomics><epilepsia><epileptogenic><excitatory neuron><gene expression pattern><gene expression signature><gene locus><genetic approach><genetic locus><genetic strategy><genome mutation><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic location><genomic locus><glia signaling><glial signaling><growth hormone release inhibiting factor><heterozygosity><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSCs><in vivo><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inhibitory neuron><intellectual and developmental disability><intervention development><limited intellectual functioning><loss of function><mRNA Differential Displays><microdeletion><migration><mouse model><mouse mutant><murine model><necropsy><nerve signaling><neural signaling><neurodevelopmental disease><neurological disease><neuron development><neuronal><neuronal development><neuronal signaling><neurotransmission><patch clamp><pathophysiology><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><postmortem><primary degenerative dementia><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sNuc-Seq><schizophrenic><senile dementia of the Alzheimer type><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social defects><social deficits><social disorders><social dysfunction><social role><therapy development><transcription factor><transcriptional profile><transcriptional signature><transcriptomics><treatment development><whole genome association analysis><whole genome association study>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Matthew J.M. Rowan

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$575,485

FY 2026

Project Title

Understanding the contribution of BCL11A to neuron function and neurological disease

Grant Number:

1R01NS146992-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY BCL11A is a zinc-finger transcription factor that has been well-studied in erythroid biology, but evidence for an important role in the brain is beginning to emerge. Patients with heterozygous loss-of-function BCL11A mutations present with clinical features that can include intellect...

Research Terms

<21+ years old><2p15><AD dementia><AD patients><ASD><Adult><Adult Human><Affect><Allelic Loss><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease patient><Alzheimer's patient><Alzheimers Dementia><Autism><Autistic Disorder><Autopsy><Basal Transcription Factor><Basal transcription factor genes><Behavior><Behavioral><Binding><Biology><Brain><Brain Nervous System><Causality><Cell Body><Cell Line><CellLine><Cells><Chromatin><Chromosomal microdeletion><Clinical><Cognitive deficits><Complex><Connector Neuron><Cyclic Somatostatin><DNA mutation><Data><Data Bases><Data Set><Databases><Development><Developmental Delay><Developmental Delay Disorders><Differential Display><Disease><Disorder><Dorsal><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Embryo><Embryonic><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Erythroid><Etiology><Exhibits><Expression Signature><Fore-Brain><Forebrain><Functional disorder><GWA study><GWAS><Gene Expression><Gene Expression Profile><Gene Targeting><General Transcription Factor Gene><General Transcription Factors><Generalized Epilepsy><Generalized Seizure Disorder><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Heterozygote><Histology><Human><Hyperactivity><In Vitro><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Jobs><KO mice><Kanner's Syndrome><Knock-out Mice><Knockout Mice><Link><Loss of Heterozygosity><Meta-Analysis><Methods><Mice><Mice Mammals><Modern Man><Molecular Interaction><Murine><Mus><Mutant Strains Mice><Mutation><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurologic><Neurologic Disorders><Neurological><Neurological Development Disorder><Neurological Disorders><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Null Mouse><Occupations><Organoids><Parvalbumins><Pathologic><Patients><Persons><Phenotype><Physiologic><Physiological><Physiopathology><Play><Population><Predisposition><Prefrontal Cortex><Primary Senile Degenerative Dementia><Professional Positions><Prosencephalon><Regulation><Research><Risk-associated variant><Role><SRIH><SRIH-14><Schizophrenia><Schizophrenic Disorders><Seizure Disorder><Seizures><Series><Single-Nucleus Sequencing><Somatostatin><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><Specific Child Development Disorders><Specific qualifier value><Specified><Strains Cell Lines><Structure><Susceptibility><Syndrome><Testing><Time><Transcription Factor Proto-Oncogene><Transcription factor genes><Translating><Zinc Finger Domain><Zinc Finger Motifs><Zinc Fingers><adulthood><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic people><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><causation><cell type><clinical phenotype><cognitive defects><cultured cell line><data base><dementia praecox><develop therapy><developmental><differential display technique><disease causation><disease phenotype><electrophysiological><epigenomics><epilepsia><epileptogenic><excitatory neuron><gene expression pattern><gene expression signature><gene locus><genetic approach><genetic locus><genetic strategy><genome mutation><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic location><genomic locus><glia signaling><glial signaling><growth hormone release inhibiting factor><heterozygosity><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSCs><in vivo><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inhibitory neuron><intellectual and developmental disability><intervention development><limited intellectual functioning><loss of function><mRNA Differential Displays><microdeletion><migration><mouse model><mouse mutant><murine model><necropsy><nerve signaling><neural signaling><neurodevelopmental disease><neurological disease><neuron development><neuronal><neuronal development><neuronal signaling><neurotransmission><patch clamp><pathophysiology><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><postmortem><primary degenerative dementia><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sNuc-Seq><schizophrenic><senile dementia of the Alzheimer type><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social defects><social deficits><social disorders><social dysfunction><social role><therapy development><transcription factor><transcriptional profile><transcriptional signature><transcriptomics><treatment development><whole genome association analysis><whole genome association study>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Zhexing Wen

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$575,485

FY 2026

Project Title

Understanding the contribution of BCL11A to neuron function and neurological disease

Grant Number:

1R01NS146992-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY BCL11A is a zinc-finger transcription factor that has been well-studied in erythroid biology, but evidence for an important role in the brain is beginning to emerge. Patients with heterozygous loss-of-function BCL11A mutations present with clinical features that can include intellect...

Research Terms

<21+ years old><2p15><AD dementia><AD patients><ASD><Adult><Adult Human><Affect><Allelic Loss><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease patient><Alzheimer's patient><Alzheimers Dementia><Autism><Autistic Disorder><Autopsy><Basal Transcription Factor><Basal transcription factor genes><Behavior><Behavioral><Binding><Biology><Brain><Brain Nervous System><Causality><Cell Body><Cell Line><CellLine><Cells><Chromatin><Chromosomal microdeletion><Clinical><Cognitive deficits><Complex><Connector Neuron><Cyclic Somatostatin><DNA mutation><Data><Data Bases><Data Set><Databases><Development><Developmental Delay><Developmental Delay Disorders><Differential Display><Disease><Disorder><Dorsal><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Embryo><Embryonic><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Erythroid><Etiology><Exhibits><Expression Signature><Fore-Brain><Forebrain><Functional disorder><GWA study><GWAS><Gene Expression><Gene Expression Profile><Gene Targeting><General Transcription Factor Gene><General Transcription Factors><Generalized Epilepsy><Generalized Seizure Disorder><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Heterozygote><Histology><Human><Hyperactivity><In Vitro><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Jobs><KO mice><Kanner's Syndrome><Knock-out Mice><Knockout Mice><Link><Loss of Heterozygosity><Meta-Analysis><Methods><Mice><Mice Mammals><Modern Man><Molecular Interaction><Murine><Mus><Mutant Strains Mice><Mutation><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurologic><Neurologic Disorders><Neurological><Neurological Development Disorder><Neurological Disorders><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Null Mouse><Occupations><Organoids><Parvalbumins><Pathologic><Patients><Persons><Phenotype><Physiologic><Physiological><Physiopathology><Play><Population><Predisposition><Prefrontal Cortex><Primary Senile Degenerative Dementia><Professional Positions><Prosencephalon><Regulation><Research><Risk-associated variant><Role><SRIH><SRIH-14><Schizophrenia><Schizophrenic Disorders><Seizure Disorder><Seizures><Series><Single-Nucleus Sequencing><Somatostatin><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><Specific Child Development Disorders><Specific qualifier value><Specified><Strains Cell Lines><Structure><Susceptibility><Syndrome><Testing><Time><Transcription Factor Proto-Oncogene><Transcription factor genes><Translating><Zinc Finger Domain><Zinc Finger Motifs><Zinc Fingers><adulthood><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic people><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><causation><cell type><clinical phenotype><cognitive defects><cultured cell line><data base><dementia praecox><develop therapy><developmental><differential display technique><disease causation><disease phenotype><electrophysiological><epigenomics><epilepsia><epileptogenic><excitatory neuron><gene expression pattern><gene expression signature><gene locus><genetic approach><genetic locus><genetic strategy><genome mutation><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic location><genomic locus><glia signaling><glial signaling><growth hormone release inhibiting factor><heterozygosity><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSCs><in vivo><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inhibitory neuron><intellectual and developmental disability><intervention development><limited intellectual functioning><loss of function><mRNA Differential Displays><microdeletion><migration><mouse model><mouse mutant><murine model><necropsy><nerve signaling><neural signaling><neurodevelopmental disease><neurological disease><neuron development><neuronal><neuronal development><neuronal signaling><neurotransmission><patch clamp><pathophysiology><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><postmortem><primary degenerative dementia><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sNuc-Seq><schizophrenic><senile dementia of the Alzheimer type><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social defects><social deficits><social disorders><social dysfunction><social role><therapy development><transcription factor><transcriptional profile><transcriptional signature><transcriptomics><treatment development><whole genome association analysis><whole genome association study>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Adam C Miller

UNIVERSITY OF OREGON, EUGENE, OR

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$574,972

FY 2026

Project Title

Molecular mechanisms of electrical synapse formation in vivo

Grant Number:

5R01NS105758-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2019

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY All of brain function, from sensory perception to behavior, is derived from the pattern and properties of the synaptic connections among billions (in humans) of individual neurons. The long-term goal of this project is to understand molecular pathways that regulate electrical synapse...

Research Terms

<21+ years old><ASD><Adopted><Adult><Adult Human><Autism><Autistic Disorder><Behavior><Behavioral><Binding><Biochemical><Biochemistry><Biologic Models><Biological><Biological Chemistry><Biological Function><Biological Models><Biological Process><Brachydanio rerio><Brain><Brain Nervous System><CNS Nervous System><Cell Adhesion><Cell Body><Cell Culture Techniques><Cell Transplantation><Cells><Cellular Adhesion><Cellular Matrix><Cellular biology><Central Nervous System><Chemical Synapse><Chemicals><Co-Immunoprecipitations><Communicating Junction><Communication><Complex><Cytoplasm><Cytoskeletal System><Cytoskeleton><Danio rerio><Defect><Development><Disease><Disorder><Early Infantile Autism><Electrical Synapse><Electrons><Electrophysiology><Electrophysiology (science)><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Family><Foundations><Gap Junctions><Genes><Genetic><Goals><Health><Human><Image><In vivo analysis><Individual><Infantile Autism><Injury><Ions><Kanner's Syndrome><Knowledge><Link><Liquid substance><Low-resistance Junction><MAGUK enzyme><Mauthner's neuron><Mediating><Medical><Microscopy><Model System><Modeling><Modern Man><Molecular><Molecular Interaction><Motor><Motor output><Myopia><Nearsightedness><Negative Beta Particle><Negatrons><Nerve Cells><Nerve Unit><Neural Cell><Neural Transmission><Neuraxis><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Neurophysiology / Electrophysiology><Nexus Junction><Occluding Junctions><Outcome><Pathway interactions><Pattern><Perception><Performance><Phase><Physiology><Property><Protein Family><Publishing><Role><Seizure Disorder><Sensory><Site><Specificity><Structure><Synapses><Synaptic><Synaptic Transmission><System><Tight Junctions><Transmission><Visualization><Work><Zebra Danio><Zebra Fish><Zebrafish><Zonula Occludens><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><biologic><cell biology><cell culture><cell cultures><cellular transplant><density><developmental><electrophysiological><epilepsia><epileptogenic><fluid><gap junction channel><human disease><imaging><in vivo><in vivo evaluation><in vivo testing><injuries><innovate><innovation><innovative><insight><intracellular skeleton><liquid><liquid dynamics><membrane-associated guanylate kinase><mutant><near vision><neural><neural circuit><neural circuitry><neural network><neurocircuitry><neurodevelopmental disease><neurogenetics><neuronal><novel><pathway><postsynaptic><presynaptic><scaffold><scaffolding><social role><synapse><synapse formation><synapse function><synaptic circuit><synaptic circuitry><synaptic function><synaptogenesis><therapeutic target><tool><trafficking><transmission process><vertebrate embryos>

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Zeba B Wunderlich

BOSTON UNIVERSITY (CHARLES RIVER CAMPUS), BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$543,664

FY 2026

Project Title

Mechanisms of shadow enhancer robustness during development

Grant Number:

5R01HD095246-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2018

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Development is a remarkably robust process. Developmental gene regulatory networks can reproducibly pattern the embryo in spite of genetic and environmental variation and the inherent molecular noise in the system. Shadow enhancers – sets of enhancers that control a single gene and drive an overlapp...

Research Terms

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Veronica Martinez-Cerdeno

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$537,189

FY 2026

Project Title

Cortical and subcortical chandelier cell pathophysiology and symptomatology in autism

Grant Number:

5R01MH094681-15

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/2/2011

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract The goal of our first funded R01 grant was to unravel the cell type(s), if any, altered in the human prefrontal cortex (PFC) in autism spectrum disorder (ASD). We discovered a decreased number of Chandelier (Ch) cells in the PFC of postmortem human tissue in ASD patients. In our first renew...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><ASD><ASD patient><Active Follow-up><Address><Aminalon><Aminalone><Ammon Horn><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anatomic Sites><Anatomic structures><Anatomy><Antibodies><Area><Astroprotein><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Autopsy><BA46><Basal Ganglia><Basal Nuclei><Behavior><Body Tissues><Brain Diseases><Brain Disorders><Cell Body><Cell Count><Cell Number><Cells><Cerebral cortex><Connector Neuron><Cornu Ammonis><Cornus><Dentate Fascia><Dysfunction><EDIL1><Early Infantile Autism><Encephalon Diseases><Fascia Dentata><Functional disorder><Funding><GABA><GFA-Protein><GFAP><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Goals><Grant><Gyrus Dentatus><Hippocampal Formation><Hippocampus><Human><Immunochemistry><Impairment><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><Lateral><MFGE8 gene><Modern Man><Motor><Neocortex><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Output><Patients><Physiopathology><Prefrontal Cortex><Progenitor Cells><Proteins><Reporting><Role><Severities><Symptoms><System><Testing><Tissue Stains><Tissues><Translating><Translational Research><Translational Science><Visual><active followup><amygdaloid nuclear complex><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic patient><autistic people><autistic spectrum disorder><case control><case-controlled><cell type><dentate gyrus><follow up><follow-up><followed up><followup><gamma-Aminobutyric Acid><hippocampal><homotypical cortex><human tissue><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><interest><isocortex><necropsy><neocortical><neopallium><nestin><nestin protein><neural cell body><neurogenesis><neuronal><neuronal cell body><pathophysiology><patient with ASD><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><postmortem><social><social role><soma><somatosensory><stem cells><symptomatology><translation research><translational investigation><γ-Aminobutyric Acid>

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Robert F Hunt

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$537,174

FY 2026

Project Title

Bidirectional control of Chd2 haploinsufficiency

Grant Number:

5R01NS126399-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Major advances have been made in mapping the genetic basis of epilepsy and other neurodevelopmental disorders (NDDs). In many cases, a candidate gene mutation has been identified, but there is no robust understanding of the neuronal causes for the particular disorder. Mutations in genes enc...

Research Terms

<21+ years old><ASD><Address><Adult><Adult Human><Ammon Horn><Anatomic Sites><Anatomic structures><Anatomy><Area><Autism><Autistic Disorder><Automobile Driving><Basic Research><Basic Science><Behavior><Behavioral><Benchmarking><Best Practice Analysis><Brain><Brain Nervous System><Brain region><CRISPR><CRISPR/Cas system><Cancer cell line><Cancers><Candidate Disease Gene><Candidate Gene><Cell Communication and Signaling><Cell Signaling><Chromatin><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Chromosome Mapping><Clinic><Clustered Regularly Interspaced Short Palindromic Repeats><Communication><Complex><Cornu Ammonis><DNA mutation><Data><Development><Diabetes Mellitus><Dimethylbiguanidine><Dimethylguanylguanidine><Disease><Disorder><Drugs><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Embryo><Embryonic><Encephalon><Engineering><Epilepsy><Epileptic Seizures><Epileptics><Event><Exhibits><Gene Alteration><Gene Expression><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Mutation><Genes><Genetic Change><Genetic Risk><Genetic defect><Genetic mutation><Genetic study><Genomics><Germ Lines><Glutamates><Heterozygote><Hippocampus><Human><Immunoblotting><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><In Vitro><Individual><Induced pluripotent stem cell derived human neuron><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intracellular Communication and Signaling><Kanner's Syndrome><L-Glutamate><Laboratories><Linkage Mapping><Literature><Malignant Neoplasms><Malignant Tumor><Mediating><Medication><Memory><Memory Deficit><Memory impairment><Metformin><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Mutation><N,N-dimethyl-imidodicarbonimidic diamide><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neurodevelopmental Disorder><Neurologic><Neurological><Neurological Development Disorder><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Pathologic><Pathology><Patients><Pharmaceutical Preparations><Photodermatitis><Photosensitivity Disorders><Population><Progenitor Cell Transplantation><Progenitor Cells><Proliferating><Pyramidal Cells><Pyramidal neuron><Reporting><Research><Seizure Disorder><Series><Signal Transduction><Signal Transduction Systems><Signaling><Stem Cell Transplantation><Stem cell transplant><Structure><Synapses><Synaptic><Testing><Therapeutic><Total Human and Non-Human Gene Mapping><Translating><Transplantation><Western Blotting><Western Immunoblotting><Work><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><behavior study><behavioral study><benchmark><biological signal transduction><chromatin modifier><developmental><diabetes><dosage><driving><drug/agent><electrophysiological><epilepsia><epileptogenic><gene defect><genetic mapping><genome mutation><glia signaling><glial signaling><glutamatergic><heterozygosity><hiPSC><hiPSC-derived neurons><hippocampal><hippocampal pyramidal neuron><human iPS><human iPSC><human iPSC-derived sensory neuron><human induced pluripotent cell><human induced pluripotent stem cell derived sensory neuron><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPSC-derived human neuron><in vivo><induced human pluripotent stem cells><inducible pluripotent stem cell derived human neuron><inducible pluripotent stem cell derived human sensory neuron><intellectual and developmental disability><life span><lifespan><limited intellectual functioning><loss of function mutation><malignancy><memory dysfunction><migration><mouse genetics><mutant allele><neoplasm/cancer><nerve signaling><neural signaling><neurodevelopment><neurodevelopmental disease><neuronal><neuronal excitability><neuronal signaling><neurons differentiated from human induced pluripotent stem cells><neurotransmission><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><pharmacologic><prevent><preventing><progenitor transplantation><protein blotting><stem and progenitor cell transplantations><stem cells><synapse><synapse function><synaptic function><therapeutic evaluation><therapeutic testing><transplant>

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Bruce D Carter

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$528,712

FY 2026

Project Title

Long distance regressive signaling underlies sculpting of the nervous system during development.

Grant Number:

5R01NS136342-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Neurodevelopmental events occurring after axons innervate their targets can be categorized as either progressive (e.g., cell survival, axon stabilization, promotion of synapse formation) or regressive (e.g., cell death, axon degeneration, synapse restriction). While the molecular and...

Research Terms

<21+ years old><AD dementia><ASD><Address><Adult><Adult Human><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Apoptosis><Apoptosis Pathway><Area><Autism><Autistic Disorder><Axon><Back><Belief><Binding><Categories><Causality><Cell Body><Cell Communication and Signaling><Cell Death><Cell Death Induction><Cell Signaling><Cell Survival><Cell Viability><Cell membrane><Cell surface><Cells><Cessation of life><Cues><Cytometry><Cytoplasmic Membrane><Data><Death><Dependence><Development><Diffuse><Distal><Dorsum><Dynein><Dynein ATPase><Dynein Adenosine Triphosphatase><Dynein Adenosinetriphosphatase><Early Infantile Autism><Endosomes><Equilibrium><Etiology><Event><GP80-LNGFR><Gehrig's Disease><Generations><Goals><Growth Cones><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><In Vitro><Infantile Autism><Intracellular Communication and Signaling><Kanner's Syndrome><Kinetics><Knowledge><Length><Ligands><Lou Gehrig Disease><Low-Affinity Nerve Growth Factor Receptor><Mediating><Mice><Mice Mammals><Molecular><Molecular Interaction><Motor><Murine><Mus><NGF Receptor><NGFR Protein><Nerve Cells><Nerve Degeneration><Nerve Growth Factor Receptor><Nerve Growth Factor Receptor p75><Nerve Unit><Nervous System><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurologic Body System><Neurologic Organ System><Neurological Development Disorder><Neuron Degeneration><Neurons><Neurotropin Receptor p75><PTK Receptors><Palmitic Acylation Site><Palmitoylation Site><Paralysis Agitans><Parkinson><Parkinson Disease><Pathologic><Pathology><Pattern><Physiologic><Physiological><Plasma Membrane><Primary Parkinsonism><Primary Senile Degenerative Dementia><Process><Programmed Cell Death><Protein Cleavage><Proteolysis><Proteolytic Clipping><Proteolytic Processing><Receptor Protein><Receptor Protein-Tyrosine Kinases><Receptor Signaling><Receptor Tyrosine Kinase Gene><Receptosomes><Regulation><Research><Role><Schizophrenia><Schizophrenic Disorders><Signal Pathway><Signal Transduction><Signal Transduction Pathway><Signal Transduction Systems><Signaling><Structure><Synapses><Synaptic><System><Techniques><Transmembrane Receptor Protein Tyrosine Kinase><Transmission><Tyrosine Kinase Linked Receptors><Tyrosine Kinase Receptors><Vesicle><Withdrawal><Work><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><axon growth><axon growth cone guidance><axon guidance><axonal degeneration><axonal growth><balance><balance function><biological signal transduction><causation><degenerative axon><dementia praecox><deprivation><developmental><disease causation><gp75 NGFR><in vivo><innervation><insight><necrocytosis><nerve cell death><nerve cell loss><nerve supply><nervous system development><neural cell body><neural degeneration><neurodegeneration><neurodegenerative><neurodevelopmental disease><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell body><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuronal survival><neurotrophic factor><neurotrophin><neutrophin><novel><p75><p75 neurotrophin receptor><p75 transcription factor><p75NTR><palmitoylation><plasmalemma><primary degenerative dementia><receptor><receptor internalization><response><retrograde transport><schizophrenic><senile dementia of the Alzheimer type><social role><soma><synapse><synapse formation><synaptogenesis><trafficking><transcriptional coactivator p75><transmission process>

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Christopher D Deppmann

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$528,712

FY 2026

Project Title

Long distance regressive signaling underlies sculpting of the nervous system during development.

Grant Number:

5R01NS136342-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Neurodevelopmental events occurring after axons innervate their targets can be categorized as either progressive (e.g., cell survival, axon stabilization, promotion of synapse formation) or regressive (e.g., cell death, axon degeneration, synapse restriction). While the molecular and...

Research Terms

<21+ years old><AD dementia><ASD><Address><Adult><Adult Human><Affect><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Apoptosis><Apoptosis Pathway><Area><Autism><Autistic Disorder><Axon><Back><Belief><Binding><Categories><Causality><Cell Body><Cell Communication and Signaling><Cell Death><Cell Death Induction><Cell Signaling><Cell Survival><Cell Viability><Cell membrane><Cell surface><Cells><Cessation of life><Cues><Cytometry><Cytoplasmic Membrane><Data><Death><Dependence><Development><Diffuse><Distal><Dorsum><Dynein><Dynein ATPase><Dynein Adenosine Triphosphatase><Dynein Adenosinetriphosphatase><Early Infantile Autism><Endosomes><Equilibrium><Etiology><Event><GP80-LNGFR><Gehrig's Disease><Generations><Goals><Growth Cones><Huntington Chorea><Huntington Disease><Huntington's><Huntington's Disease><Huntingtons Disease><In Vitro><Infantile Autism><Intracellular Communication and Signaling><Kanner's Syndrome><Kinetics><Knowledge><Length><Ligands><Lou Gehrig Disease><Low-Affinity Nerve Growth Factor Receptor><Mediating><Mice><Mice Mammals><Molecular><Molecular Interaction><Motor><Murine><Mus><NGF Receptor><NGFR Protein><Nerve Cells><Nerve Degeneration><Nerve Growth Factor Receptor><Nerve Growth Factor Receptor p75><Nerve Unit><Nervous System><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurologic Body System><Neurologic Organ System><Neurological Development Disorder><Neuron Degeneration><Neurons><Neurotropin Receptor p75><PTK Receptors><Palmitic Acylation Site><Palmitoylation Site><Paralysis Agitans><Parkinson><Parkinson Disease><Pathologic><Pathology><Pattern><Physiologic><Physiological><Plasma Membrane><Primary Parkinsonism><Primary Senile Degenerative Dementia><Process><Programmed Cell Death><Protein Cleavage><Proteolysis><Proteolytic Clipping><Proteolytic Processing><Receptor Protein><Receptor Protein-Tyrosine Kinases><Receptor Signaling><Receptor Tyrosine Kinase Gene><Receptosomes><Regulation><Research><Role><Schizophrenia><Schizophrenic Disorders><Signal Pathway><Signal Transduction><Signal Transduction Pathway><Signal Transduction Systems><Signaling><Structure><Synapses><Synaptic><System><Techniques><Transmembrane Receptor Protein Tyrosine Kinase><Transmission><Tyrosine Kinase Linked Receptors><Tyrosine Kinase Receptors><Vesicle><Withdrawal><Work><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><axon growth><axon growth cone guidance><axon guidance><axonal degeneration><axonal growth><balance><balance function><biological signal transduction><causation><degenerative axon><dementia praecox><deprivation><developmental><disease causation><gp75 NGFR><in vivo><innervation><insight><necrocytosis><nerve cell death><nerve cell loss><nerve supply><nervous system development><neural cell body><neural degeneration><neurodegeneration><neurodegenerative><neurodevelopmental disease><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell body><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuronal survival><neurotrophic factor><neurotrophin><neutrophin><novel><p75><p75 neurotrophin receptor><p75 transcription factor><p75NTR><palmitoylation><plasmalemma><primary degenerative dementia><receptor><receptor internalization><response><retrograde transport><schizophrenic><senile dementia of the Alzheimer type><social role><soma><synapse><synapse formation><synaptogenesis><trafficking><transcriptional coactivator p75><transmission process>

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Anju Vasudevan

HUNTINGTON MEDICAL RESEARCH INSTITUTES, Pasadena, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$524,333

FY 2026

Project Title

Novel Developmental Pathways Underlying Psychiatric Disorders

Grant Number:

5R01MH110438-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2016

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract The central nervous system (CNS) acquires its vasculature by angiogenesis, a process that is critical for its development and repair. Our findings have offered new perspectives on intrinsic regulation of angiogenesis and highlighted the importance of vascular diversity during brain develop...

Research Terms

<21+ years old><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><ASD><Adult><Adult Human><Affect><Aminalon><Aminalone><Anxiety><Autism><Autistic Disorder><Behavior><Behavioral><Birth><Blood Vessels><Blood flow><Brain><Brain Nervous System><CNS Nervous System><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Cerebral cortex><Cerebral endothelium><Cerebrovascular system><Communication><Complex><Cues><Defect><Development><Disease><Disorder><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Embryo><Embryonic><Encephalon><Endothelial Cells><Endothelium><Epilepsy><Epileptic Seizures><Epileptics><Etiology><Event><Expression Signature><Filamentous Fungi><Fore-Brain><Forebrain><GABA><GABA Receptor><GABA transporter 3><GAD1 enzyme><GAD2 enzyme><GAD65 enzyme><GAD67 enzyme><GAT-3 transporter><GAT3 transporter><Gene Expression><Gene Expression Profile><Genes><Goals><Hind Brain><Individual><Infantile Autism><Intracellular Communication and Signaling><Kanner's Syndrome><Mediating><Mental Depression><Mental disorders><Mental health disorders><Mesencephalon><Mice><Mice Mammals><Microcirculation><Mid-brain><Midbrain><Midbrain structure><Molds><Molecular><Moods><Murine><Mus><Neocortex><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Neurovascular dysfunction><Obsessive-Compulsive Disorder><Obsessive-Compulsive Neurosis><Parturition><Pathogenesis><Pathway interactions><Phase><Population><Position><Positioning Attribute><Process><Prosencephalon><Psychiatric Disease><Psychiatric Disorder><Public Health><Receptor Protein><Regulation><Research><Rhombencephalon><Role><SLC6A11 protein><Schizophrenia><Schizophrenic Disorders><Seizure Disorder><Shapes><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Time><VGAT transporter><Variant><Variation><Vascularization><Ventricular><Work><adulthood><angiogenesis><anxiety-related disorders><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><biological signal transduction><blood vessels in the brain><brain blood vessels><brain endothelium><brain vasculature><causation><cerebral blood vessel><cerebral vasculature><cerebrovascular vessels><cerebrovasculature><conditional knock-out><conditional knockout><cortical endothelium><dementia praecox><depression><design><designing><developmental><disease causation><early embryonic stage><electrophysiological><epilepsia><epileptogenic><gamma-Aminobutyric Acid><gamma-Aminobutyric Acid Receptors><gene expression pattern><gene expression signature><glia signaling><glial signaling><glutamate decarboxylase GAD65><hindbrain><homotypical cortex><in vivo><insight><isocortex><loss of function><mental illness><migration><neocortical><neopallium><nerve signaling><neural signaling><neuro-vascular><neuronal><neuronal signaling><neuropsychiatric><neuropsychiatric disease><neuropsychiatric disorder><neuropsychiatry><neurotransmission><neurovascular><neurovascular abnormality><neurovascular dysregulation><neurovascular impairment><neurovascular pathology><neurovasculopathy><novel><pathway><post-natal development><post-natal period><postnatal><postnatal development><postnatal period><prenatal><programs><psychiatric illness><psychological disorder><receptor><repair><repaired><schizophrenic><social role><solute carrier family-6 (neurotransmitter transporter, GABA), member 11><spatial and temporal><spatial temporal><spatiotemporal><transcriptional profile><transcriptional signature><unborn><vascular><vascular component><vascular factor><vascular regression><vesicular GABA transporter><vessel regression><γ-Aminobutyric Acid>

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Daniel Feldman

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$521,993

FY 2026

Project Title

Sensory regulation of interneuron intrinsic excitability in sensorycortex

Grant Number:

5R01NS134639-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary Inhibitory interneurons in cerebral cortex show rapid plasticity of intrinsic excitability in response to sensory experience and learning. The molecular mechanisms and functions of such plasticity, and its potential role in disease, are poorly understood. We study this in mouse somatosensory...

Research Terms

View Full Project Details on NIH Reporter

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Li Wang

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$521,963

FY 2026

Project Title

Computational Neuroimaging MRI for Studying Early Brain Development with Autism

Grant Number:

5R01MH133845-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Title: Computational Neuroimaging MRI for Studying Early Brain Development with Autism Due to the absence of early biomarkers of autism, diagnosis must rely on behavioral observations long after birth, leading to missed opportunities for early intervention. Thus, it is of great importance to detect ...

Research Terms

<0-11 years old><ASD><Achievement><Achievement Attainment><Address><Atlases><Attention><Autism><Autism Diagnosis><Autistic Disorder><Awareness><Behavior><Biological Markers><Birth><Body Tissues><Brain><Brain Nervous System><Brain imaging><Cerebellar Cortex><Cerebellum><Cerebral cortex><Cerebrum><ChatGPT><Child><Child Youth><Childhood><Children (0-21)><Clinical><Computational toolkit><ConvNet><DWI (diffusion weighted imaging)><DWI-MRI><Data><Data Bases><Data Set><Databases><Dedications><Development><Diagnosis><Diffusion><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Early Diagnosis><Early Infantile Autism><Early Intervention><Effectiveness><Encephalon><Ensure><Exhibits><Free Will><Functional MRI><Functional Magnetic Resonance Imaging><GPT-2><GPT-3><GPT-4><Generalized Growth><Goals><Grain><Growth><Hybrids><Image><Image Enhancement><Infant><Infantile Autism><Intervention><Joints><Kanner's Syndrome><Life><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Maps><Measurement><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Modeling><NMR Imaging><NMR Tomography><Nuclear Magnetic Resonance Imaging><Outcome><Parturition><Pattern><Process><Protocol><Protocols documentation><Research><Resolution><Risk><Scanning><Semantics><Social Interaction><Source><Structure><Surface><Testing><Tissue Growth><Tissues><Training><Variant><Variation><Vendor><Visit><Zeugmatography><autism biomarker><autism marker><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior observation><behavioral observation><bio-markers><biologic marker><biomarker><biomarker identification><brain tissue><brain visualization><cerebral><computational toolbox><computational tools><computational toolset><computerized tools><connectome><contrast enhanced><convolutional network><convolutional neural nets><convolutional neural network><dMRI><data base><data diversity><data heterogeneity><data set heterogeneity><data to train><dataset heterogeneity><dataset to train><developmental><diffused><diffuses><diffusing><diffusion tensor imaging><diffusions><diverse data><early biomarkers><early detection><early detection biomarkers><early detection markers><effective intervention><experience><fMRI><facilities for imaging><graph attention network><graph convolutional network><graph neural network><heterogeneous data><heterogeneous data sets><heterogeneous datasets><heterogenous data><heterogenous data sets><heterogenous datasets><identification of biomarkers><identification of new biomarkers><imaging><imaging biomarker><imaging center><imaging facilities><imaging marker><imaging study><imaging-based biological marker><imaging-based biomarker><imaging-based marker><imaging-related facilities><improved><infant measurement><infant monitoring><innovate><innovation><innovative><insight><kids><learning network><marker identification><multi-modal neuro-imaging><multi-modality><multidisciplinary><multimodal neuroimaging><multimodality><myelination><neural imaging><neuro-imaging><neuroimaging><neurological imaging><novel><ontogeny><pediatric><resolutions><social communication><super high resolution><superresolution><tool><training data><ultra high resolution><youngster>

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Alexander Chubykin

PURDUE UNIVERSITY, WEST LAFAYETTE, IN

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$489,661

FY 2026

Project Title

Neural Mechanisms of Predictive Impairments in Autism

Grant Number:

5R01MH116500-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2017

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Autism spectrum disorders (ASDs) are characterized by altered sensory processing and intellectual disability. Atypical sensory processing has been recognized as an important diagnostic criterion for autism and is predictive of social communication deficits later in life. ASDs are also associated wit...

Research Terms

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Ning Quan

FLORIDA ATLANTIC UNIVERSITY, BOCA RATON, FL

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$486,158

FY 2026

Project Title

Neuroinflammation, neuronal IL-1R1, and behavior

Grant Number:

2R01NS116914-06A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2020

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY The physiological function of neuronal IL-1R1 is not understood. In the last funding cycle of this project, we have demonstrated that neuronal IL-1R1 is critical for chronic social stress-induced changes in behavior. In this renewal, we propose that the physiological function of the ...

Research Terms

<21+ years old><AAV vector><AAV-based vector><ASD><Adhesions><Adult><Adult Human><Ammon Horn><Autism><Autistic Disorder><Behavior><Behavioral><Brain><Brain Nervous System><Brain region><CNS Diseases><CNS disorder><Cell Communication and Signaling><Cell Signaling><Central Nervous System Diseases><Central Nervous System Disorders><Chronic><Cognitive><Cornu Ammonis><Dorsal><Early Infantile Autism><Encephalon><Funding><Genes><Hippocampus><IL-1><IL-1 Receptors><IL1><IL1 Receptors><Immune response><Infantile Autism><Inflammation><Interleukin I><Interleukin-1><Interleukin-1 Receptors><Intracellular Communication and Signaling><KO mice><Kanner's Syndrome><Knock-in><Knock-out Mice><Knockout Mice><Knowledge><Learning><Lymphocyte-Stimulating Hormone><Macrophage Cell Factor><Maps><Mediating><Mental disorders><Mental health disorders><Messenger RNA><Mice><Mice Mammals><Molecular><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Null Mouse><Pathogenesis><Pathway interactions><Pattern><Physiologic><Physiological><Proteins><Psychiatric Disease><Psychiatric Disorder><Psychiatric therapeutic procedure><Publishing><Receptor Protein><Regulation><Reporter><Role><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Social Behavior><Social Discrimination><Synapses><Synaptic><T Helper Factor><Visualization><adeno-associated viral vector><adeno-associated virus vector><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><biological signal transduction><cell type><conditional knock-out><conditional knockout><critical period><experience><granule cell><hippocampal><host response><immune system response><immunoresponse><information processing><knockin><lymphocyte activating factor><mRNA><mental illness><mouse model><murine model><neural inflammation><neuroinflammation><neuroinflammatory><neuronal><neurophysiological><neurophysiology><novel><pathway><promoter><promotor><psychiatric care><psychiatric illness><psychiatric therapy><psychiatric treatment><psychological disorder><receptor><response><social><social role><social stress><socially stressed><sociobehavior><sociobehavioral><spatial and temporal><spatial temporal><spatiotemporal><synapse><synapse function><synaptic function><synaptic pruning>

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Gang Li

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$483,218

FY 2026

Project Title

Continued Development of Infant Neuroimaging Analysis Tools

Grant Number:

5R01EB037388-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

The first two years are an exceptionally dynamic and critical period of brain development, featuring significant growth in both cerebrum and cerebellum. The availability of large-scale, multi-site infant MRI datasets, e.g., the developing Human Connectome Project (dHCP), Baby Connectome Project (BCP...

Research Terms

<21+ years old><ASD><Address><Adult><Adult Human><Anatomic Sites><Anatomic structures><Anatomy><Appearance><Area><Atlases><Autism><Autistic Disorder><Body Tissues><Brain><Brain Mass><Brain Nervous System><Cell Body><Cells><Cerebellar Cortex><Cerebellum><Cerebrum><Characteristics><Child Development><Code><Coding System><Communication><Communities><Computational toolkit><Computer Software Development><Computer Software Engineering><Computer software><Data><Data Bases><Data Set><Databases><Dedications><Development><Documentation><Early Infantile Autism><Emotional><Encephalon><Exhibits><Feedback><Fees><Fortification><Generalized Growth><Growth><Human><Image><Individual><Infant><Infant Development><Infant and Child Development><Infantile Autism><Institution><Journals><Kanner's Syndrome><Leanness><Learning><MR Imaging><MR Tomography><MRI><MRIs><Magazine><Magnetic Resonance Imaging><Maps><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Modeling><Modern Man><Motion><Myelin><NMR Imaging><NMR Tomography><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Nuclear Magnetic Resonance Imaging><Pattern><Performance><Play><Population><Process><Property><Protocol><Protocols documentation><Publications><Reporting><Research><Resolution><Role><Scanning><Scientific Publication><Shapes><Site><Software><Software Engineering><Structure><Surface><Techniques><Thick><Thickness><Thinness><Tissue Growth><Tissue imaging><Tissues><Training><Transmission><Work><Zeugmatography><adult youth><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><brain MR imaging><brain MRI><brain magnetic resonance imaging><brain size><cerebral><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><cognitive function><computational toolbox><computational tools><computational toolset><computerized tools><connectome><critical period><data base><data to train><dataset to train><deep learning><deep learning method><deep learning strategy><design><designing><developmental><image registration><imaging><improved><infancy><infantile><innovate><innovation><innovative><insight><motor control><neural imaging><neural network><neuro-imaging><neurodevelopmental disease><neuroimaging><neurological imaging><neuronal><novel><ontogeny><outreach><preservation><reconstruction><resolutions><self-attention><social role><spatial and temporal><spatial temporal><spatiotemporal><tissue map><tissue mapping><tool><training data><transmission process><unsupervised learning><unsupervised machine learning><usability><young adult><young adult age><young adulthood>

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Li Wang

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$483,218

FY 2026

Project Title

Continued Development of Infant Neuroimaging Analysis Tools

Grant Number:

5R01EB037388-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

The first two years are an exceptionally dynamic and critical period of brain development, featuring significant growth in both cerebrum and cerebellum. The availability of large-scale, multi-site infant MRI datasets, e.g., the developing Human Connectome Project (dHCP), Baby Connectome Project (BCP...

Research Terms

<21+ years old><ASD><Address><Adult><Adult Human><Anatomic Sites><Anatomic structures><Anatomy><Appearance><Area><Atlases><Autism><Autistic Disorder><Body Tissues><Brain><Brain Mass><Brain Nervous System><Cell Body><Cells><Cerebellar Cortex><Cerebellum><Cerebrum><Characteristics><Child Development><Code><Coding System><Communication><Communities><Computational toolkit><Computer Software Development><Computer Software Engineering><Computer software><Data><Data Bases><Data Set><Databases><Dedications><Development><Documentation><Early Infantile Autism><Emotional><Encephalon><Exhibits><Feedback><Fees><Fortification><Generalized Growth><Growth><Human><Image><Individual><Infant><Infant Development><Infant and Child Development><Infantile Autism><Institution><Journals><Kanner's Syndrome><Leanness><Learning><MR Imaging><MR Tomography><MRI><MRIs><Magazine><Magnetic Resonance Imaging><Maps><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Modeling><Modern Man><Motion><Myelin><NMR Imaging><NMR Tomography><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Nuclear Magnetic Resonance Imaging><Pattern><Performance><Play><Population><Process><Property><Protocol><Protocols documentation><Publications><Reporting><Research><Resolution><Role><Scanning><Scientific Publication><Shapes><Site><Software><Software Engineering><Structure><Surface><Techniques><Thick><Thickness><Thinness><Tissue Growth><Tissue imaging><Tissues><Training><Transmission><Work><Zeugmatography><adult youth><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><brain MR imaging><brain MRI><brain magnetic resonance imaging><brain size><cerebral><cerebral MR imaging><cerebral MRI><cerebral magnetic resonance imaging><cognitive function><computational toolbox><computational tools><computational toolset><computerized tools><connectome><critical period><data base><data to train><dataset to train><deep learning><deep learning method><deep learning strategy><design><designing><developmental><image registration><imaging><improved><infancy><infantile><innovate><innovation><innovative><insight><motor control><neural imaging><neural network><neuro-imaging><neurodevelopmental disease><neuroimaging><neurological imaging><neuronal><novel><ontogeny><outreach><preservation><reconstruction><resolutions><self-attention><social role><spatial and temporal><spatial temporal><spatiotemporal><tissue map><tissue mapping><tool><training data><transmission process><unsupervised learning><unsupervised machine learning><usability><young adult><young adult age><young adulthood>

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LIZABETH M ROMANSKI

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$469,692

FY 2026

Project Title

Audiovisual Integration in the Prefrontal Cortex

Grant Number:

5R01DC004845-24

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2001

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Social communication depends on the integration of sensory, emotional and cognitive information by a large network of brain regions. While many brain regions integrate auditory and visual information, the inferior frontal lobes (IFG) receive a wealth of sensory afferents from multiple modalities, ha...

Research Terms

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Ege T Kavalali

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$441,790

FY 2026

Project Title

Role of SNARE Interactions in Central Synapse Function

Grant Number:

5R01NS134128-24

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2003

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project-Summary Recent studies have identified a large number of variants in SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) machinery components such as SNAP25 that give rise to intractable early childhood brain disorders. In this project, we will use rodent hippocampa...

Research Terms

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Marco Venniro

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$412,962

FY 2026

Project Title

Behavioral and neural mechanisms mediating social motivation in a rat model for ASD

Grant Number:

5R01MH129310-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/16/2022

End Date:

10/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Autism spectrum disorder (ASD) is characterized by impaired social communication, often attributed to misreading of emotional cues. Despite progress toward understanding ASD, treatment options remain limited. This is partly due to limitations of animal models of ASD that fail to capt...

Research Terms

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BENJAMIN D PHILPOT

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$404,368

FY 2026

Project Title

Investigating UBE3A as a driver gene in Duplication 15q syndrome

Grant Number:

5R01NS129914-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Maternal duplication of the chromosome 15q11-q13 locus (Dup15q syndrome) is a major genetic cause of autism spectrum disorder. UBE3A is contained within this genetic locus; compelling evidence suggests it is the main driver of Dup15q syndrome pathophysiology. Accordingly, the normali...

Research Terms

<15q+ syndrome><21+ years old><ASD><Aberrant Chromosome><Accounting><Adolescent><Adolescent Youth><Adult><Adult Human><Age><Antisense Agent><Antisense Oligonucleotides><Autism><Autistic Disorder><Behavioral><Biologic Sciences><Biological Sciences><Bioscience><Brain><Brain Nervous System><Cell Body><Cells><Chromosomal Aberrations><Chromosomal Abnormalities><Chromosomal Alterations><Chromosome 15><Chromosome Aberrations><Chromosome Alterations><Chromosome Anomalies><Chromosome abnormality><Chromosomes><Clinical Trials><Coupled><Cytogenetic Aberrations><Cytogenetic Abnormalities><Data><Disease><Disorder><Dose><Dysfunction><E6AP><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Engineering><Epilepsy><Epileptic Seizures><Epileptics><Frequencies><Functional disorder><Future><Gene Copy Number><Gene Dosage><Gene Expression><Genes><Genetic><Human><In Vitro><Infantile Autism><Intervention><Intervention Strategies><Isodicentric Chromosome><Kanner's Syndrome><Lead><Life Sciences><Maps><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Neonatal><Neurodevelopmental Disorder><Neurological Development Disorder><Neurophysiology / Electrophysiology><Outcome><Pathology><Pb element><Phenotype><Physiologic><Physiological><Physiopathology><Population><Proteins><SUDEP><Seizure Disorder><Seizures><Severities><Syndrome><Testing><Therapeutic><Therapeutic Intervention><Transgenes><Transgenic Organisms><UBE3A><UBE3A gene><Ubiquitin-Protein Ligase E3A><Work><adulthood><ages><antisense oligo><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><candidate identification><chromosomal defect><chromosome 15q duplication syndrome><chromosome 15q gain><chromosome 15q trisomy><chromosome defect><critical period><design><designing><dup15q syndrome><duplication 15q syndrome><electrophysiological><epilepsia><epileptogenic><gene locus><genetic locus><genomic location><genomic locus><heavy metal Pb><heavy metal lead><idic><in vivo><interstitial><intervention therapy><juvenile><juvenile human><knock-down><knockdown><mortality><mouse model><murine model><neurodevelopmental disease><overexpress><overexpression><partial trisomy 15q><pathophysiology><pharmacologic><postnatal><pre-clinical study><preclinical study><primary end point><primary endpoint><prospective><sudden unexpected death in epilepsy><tool><transgene><transgenic><trisomy 15q>

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Gabriel Kreiman

HARVARD MEDICAL SCHOOL, BOSTON, MA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$400,601

FY 2026

Project Title

CRCNS: Neural and computational mechanisms underlying natural viewing behavior

Grant Number:

5R01EY038608-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2025

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Primates—including humans and macaques—make rapid, instinctive eye movements to explore the visual world, prioritize information, and guide future actions. This preferential viewing behavior is essential for perception, social interaction, and decision-making, yet the underlying neural and computa...

Research Terms

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CARLOS Ramon PONCE

HARVARD MEDICAL SCHOOL, BOSTON, MA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$400,601

FY 2026

Project Title

CRCNS: Neural and computational mechanisms underlying natural viewing behavior

Grant Number:

5R01EY038608-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2025

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Primates—including humans and macaques—make rapid, instinctive eye movements to explore the visual world, prioritize information, and guide future actions. This preferential viewing behavior is essential for perception, social interaction, and decision-making, yet the underlying neural and computa...

Research Terms

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Julie Christina Markant

TULANE UNIVERSITY OF LOUISIANA, NEW ORLEANS, LA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$393,896

FY 2026

Project Title

Longitudinal investigation of endogenous and social-motivational predictors of infants' attention to caregivers

Grant Number:

5R01HD108325-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY/ABSTRACT Caregivers are both socially rewarding and a crucial source of learning input, and infants’ ability to prioritize attention to their caregiver over other competing stimuli is critical for effective early learning. Altered processing of social reward is common across several atypical...

Research Terms

<0-11 years old><21+ years old><ASD><Address><Adult><Adult Human><Age><Age Months><Attention><Autism><Autistic Disorder><Behavior><Behavioral><Birth><Care Givers><Caregivers><Child><Child Youth><Children (0-21)><Code><Coding System><Data><Development><Diagnosis><Early Infantile Autism><Emotional><Environment><Exhibits><Face><Familiarity><Goals><Individual><Infant><Infant Development><Infantile Autism><Intervention><Kanner's Syndrome><Learning><Link><Measures><Motivation><Paired Comparison><Parturition><Process><Research><Rewards><Role><Shapes><Source><Speech><Stimulus><System><Time><Work><adulthood><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age related alterations><age related changes><age specific alterations><age specific changes><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><attentional bias><attentional control><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><care giving><caregiving><changes with age><cognitive skill><depressed mother><developmental><experience><experiment><experimental research><experimental study><experiments><eye tracking><faces><facial><flexibility><flexible><infancy><infantile><insight><investigate longitudinal><kids><learning outcome><longitudinal investigation><longitudinal research><maternal depression><reward processing><skills><social><social role><study longitudinal><survey longitudinal><visual tracking><youngster>

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Wei Ji Ma

NEW YORK UNIVERSITY, NEW YORK, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$389,225

FY 2026

Project Title

Identifying the neural correlates of mental simulation in multi-step planning

Grant Number:

5R01MH134979-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/20/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Planning, the ability to mentally simulate possible futures toward a goal, is essential for everyday decision-making. Indeed, many psychiatric and neurological disorders are associated with dysfunctions in planning, including obsessive-compulsive disorder and autism spectrum...

Research Terms

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Tingting Wang

GEORGETOWN UNIVERSITY, WASHINGTON, DC

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$355,486

FY 2026

Project Title

Functional Mapping of Chd1-dependent Signaling Network in Synaptic Homeostasis

Grant Number:

5R01MH134978-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract Autism Spectrum Disorder (ASD) is a highly prevalent neurodevelopmental disorder characterized by significant developmental, intellectual, and behavioral impairments. Patients with ASD exhibit comorbid conditions and common features shared with epilepsy and intellectual disability (ID), sug...

Research Terms

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Wei Li

HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES, EAST LANSING, MI

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$340,297

FY 2026

Project Title

The Pathophysiological Role of Cerebellar Glia in Rett Syndrome

Grant Number:

5R01NS121542-06

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2021

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Rett syndrome (RTT) is the leading cause of severe intellectual disability in girls and women. Individuals with RTT develop typically until 6-18 months, when autism-like behaviors and deficits in purposeful hand use and speech start to dev...

Research Terms

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Teresa L. Head-Gordon

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$274,105

FY 2026

Project Title

Calculating Ensembles of Discrete Dynamic Complexes and Condensed States of Intrinsically Disordered Proteins

Grant Number:

5R01GM127627-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2018

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

The traditional structure-function paradigm has provided significant insights for well-folded proteins in which structures can be easily and rapidly revealed by X-ray crystallography beamlines and NMR. However approximately one third of the human proteome are comprised of intrinsically disordered pr...

Research Terms

<3-D structure><3-dimensional structure><3D structure><ASD><Address><Adopted><Autism><Autistic Disorder><BP2><Back><Bayesian Modeling><Bayesian adaptive designs><Bayesian adaptive models><Bayesian belief network><Bayesian belief updating model><Bayesian framework><Bayesian hierarchical model><Bayesian network model><Bayesian nonparametric models><Bayesian spatial data model><Bayesian spatial image models><Bayesian spatial models><Bayesian statistical models><Bayesian tracking algorithms><Binding Proteins><Biological><Biology><C-terminal><Cancers><Cardiovascular Diseases><Chemicals><Collaborations><Color><Complex><Computational toolkit><Computer software><Computing Methodologies><Data><Development><Disease><Disorder><Dorsum><Early Infantile Autism><Elasticity><Elastin><Electrostatics><Eukaryotic Initiation Factors><Eukaryotic Peptide Initiation Factors><Eukaryotic Translation Initiation Factors><FRET><Fluorescence><Fluorescence Resonance Energy Transfer><Förster Resonance Energy Transfer><Generations><Grain><Grant><Human><IBP2><IDP><IGF-BP53><IGFBP2><IGFBP2 gene><Infantile Autism><Inosine Diphosphate><Inosine Pyrophosphate><Insulin-Like Growth Factor Binding Protein 2><Kanner's Syndrome><Letters><Ligand Binding Protein><Ligand Binding Protein Gene><Machine Learning><Malignant Neoplasms><Malignant Tumor><Measures><Methods><Modeling><Modern Man><Molecular Dynamics Simulation><Non-Polyadenylated RNA><Pathologic><Phase><Phosphorylation><Physical condensation><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Prevalence><Protein Binding><Protein Modification><Protein Phosphorylation><Proteins><Proteome><RNA><RNA Gene Products><Regulation><Relaxation><Research><Residual><Residual state><Ribonucleic Acid><Riboxin><Riboxine><Roentgen Rays><Role><Sampling><Single Crystal Diffraction><Software><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Structure><Surface><Translational Regulation><Translations><Tropoelastin><Update><Validation><X Ray Crystallographies><X-Radiation><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray Radiation><X-Ray/Neutron Crystallography><X-ray><Xray><Xray Crystallography><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><beamline><biologic><bound protein><cardiovascular disorder><cartilage link protein><computational methodology><computational methods><computational toolbox><computational tools><computational toolset><computer based method><computer methods><computerized tools><computing method><condensation><developmental><experiment><experimental research><experimental study><experiments><frontier><insight><link protein><machine based learning><machine learning based method><machine learning method><machine learning methodologies><malignancy><molecular dynamics><monomer><neoplasm/cancer><novel><physical model><protein folding><protein structure function><single molecule><single-molecule FRET><single-molecule fluorescence resonance energy transfer><smFRET><social role><structural biology><three dimensional structure><tool><translation><validations>

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Stephan Sanders

UNIVERSITY OF OXFORD, UNITED KINGDOM

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$267,339

FY 2026

Project Title

4/4 - The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder

Grant Number:

5R01MH129751-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT The past decade has seen outstanding advances in the genetics of autism spectrum disorder (ASD). Most of this progress has occurred by the study of rare genetic variation, especially de novo variation, with the Autism Sequencing Consortium (ASC) playing a central role. The A...

Research Terms

<1st trimester><21+ years old><ANK2><ANK2 gene><ASD><Acceleration><Adult><Adult Human><Affect><Ankyrin 2><Ankyrin-B><Autism><Autistic Disorder><Brain Ankyrin><Brain Diseases><Brain Disorders><Cell Communication and Signaling><Cell Signaling><Clinical><Copy Number Polymorphism><DNA mutation><Data><Development><Diagnosis><Disease><Disorder><Early Infantile Autism><Early Placental Phase><Encephalon Diseases><Family><First Pregnancy Trimester><First Trimester><Foundations><General Population><General Public><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Risk><Genetic Variation><Genetic defect><Genetic mutation><Goals><Hereditary><Heterogeneity><Individual><Infantile Autism><Inherited><International><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><Learning><Link><Mental disorders><Mental health disorders><Methods><Missense Mutation><Mission><Mutation><NIH><National Institutes of Health><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Ankyrin><Nonerythroid Ankyrin><Nucleotides><Outcome><Pathogenesis><Pathway interactions><Pattern><Play><Population><Prevention><Process><Psychiatric Disease><Psychiatric Disorder><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><RFX3><Recommendation><Research><Research Grants><Research Project Grants><Research Projects><Research Resources><Resources><Risk><Risk-associated variant><Role><SEQ-AN><Sampling><Sequence Analyses><Sequence Analysis><Signal Transduction><Signal Transduction Systems><Signaling><Site><Source><Statistical Methods><Symptoms><TOPMed><Trans-Omics for Precision Medicine><Transmission><United States National Institutes of Health><Variant><Variation><adulthood><analytical method><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><biological signal transduction><cell type><cohort><copy number variant><copy number variation><developmental><developmental disease><developmental disorder><discover genes><disease risk><disorder risk><entire genome><exome><full genome><functional genomics><gain of function><gene discovery><genetic architecture><genome mutation><genomic data><genomic dataset><improved><indel><innovate><innovation><innovative><insertion/deletion><insertion/deletion mutation><insight><loss of function><low-frequency mutation><mental illness><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><neurodevelopmental disease><neuropsychiatric disease><neuropsychiatric disorder><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><population based><psychiatric illness><psychological disorder><rare allele><rare mutation><rare variant><repetitive behavior><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sex><social defects><social deficits><social disorders><social dysfunction><social role><statistic methods><therapeutic target><transmission process><whole genome>

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Jessie B Northrup

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$174,718

FY 2026

Project Title

Parent-Child Interaction and Emotion Regulation in Preschoolers with Autism Spectrum Disorder

Grant Number:

5K23MH127420-05

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Emotion regulation (ER) impairments in children with autism spectrum disorder (ASD) exacerbate social difficulties, increase parental stress, and limit functioning. The preschool years mark a significant period in typical ER development during which parent-child interactions play a c...

Research Terms

<0-11 years old><4 year old><4 years of age><ASD><Arousal><Autism><Autistic Disorder><Behavior><Behavioral><Biological><Care Givers><Caregivers><Cell Communication and Signaling><Cell Signaling><Child><Child Development><Child Youth><Children (0-21)><Clinical><Code><Coding System><Collection><Communication><Complex><Cues><Data><Development><Diagnosis><Distress><Drug Prescribing><Drug Prescriptions><Early Infantile Autism><Early identification><Emotional><Emotions><Environment><Expressed Emotion><Face><Family><Fear><Foundations><Fright><Goals><Home><Hospital Admission><Hospitalization><Impairment><Individual Differences><Infant><Infant and Child Development><Infantile Autism><Inpatients><Intervention><Intracellular Communication and Signaling><Kanner's Syndrome><Knowledge><Link><Machine Learning><Measurement><Measures><Mentors><Methodology><Modality><Monitor><Nursery Schools><Parent-Child Relations><Parent-Child Relationship><Parents><Peripheral><Physiologic><Physiological><Physiology><Play><Population><Position><Positioning Attribute><Problem behavior><Process><Psychiatry><Psychologist><Qualifying><Reporting><Research><Risk Assessment><Risk Factors><Role><Sampling><School-Age Population><Series><Signal Transduction><Signal Transduction Systems><Signaling><Social Processes><Stress><Techniques><Testing><Time><Training><Universities><Videotape><age 4><age 4 years><autism spectral disorder><autism spectrum disorder><autistic children><autistic individuals><autistic people><autistic spectrum disorder><behavior response><behavioral problem><behavioral response><biobehavior><biobehavioral><biologic><biological signal transduction><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><developmental><emotion regulation><emotional distress><emotional expression><emotional regulation><experience><expression of emotion><faces><facial><feeling distress><feeling upset><four year old><four years of age><high risk><homes><indexing><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><innovate><innovation><innovative><investigate longitudinal><kids><longitudinal investigation><longitudinal research><machine based learning><machine learning based method><machine learning method><machine learning methodologies><medication prescription><multi-modality><multimodality><non-speaking><non-verbal><non-vocal><parent><parent child interaction><parent offspring interaction><peer><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><positive emotion><positive emotional state><pre-k><pre-kindergarten><preschool><prescribed medication><primary care giver><primary caregiver><programs><prospective><response><scaffold><scaffolding><school age><showing emotion><skills><social><social communication><social role><study longitudinal><survey longitudinal><verbal><youngster>

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Antonio Francisco Pagán

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$132,027

FY 2026

Project Title

Psychosocial and Neural Mechanisms for a Culturally and Linguistically Adapted Treatment for Bilingual Latino Young Adults with Autism

Grant Number:

5K99HD118079-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Candidate: This K99/R00 Pathway to Independence Award proposal aims to provide me with the training needed (K99 phase) to execute mental health clinical trials (R00 phase) for Latinos with autism spectrum disorder (ASD) during their transition to adulthood.1 My preliminary community-based participat...

Research Terms

<21+ years old><ASD><Acceleration><Active Follow-up><Address><Adolescent><Adolescent Youth><Adult><Adult Human><After Care><After-Treatment><Aftercare><Anterior><Anxiety><Area><Autism><Autistic Disorder><Autistic young adult><Award><Behavior><Biological Markers><Brain><Brain Nervous System><Central Lobe><Childhood><Clinical Sciences><Clinical Treatment><Clinical Trials><Communities><Community Health Aides><Data><Development><Early Infantile Autism><Early-Stage Clinical Trials><Emotions><Encephalon><Ensure><Espanol><Evidence based treatment><Face><Fellowship><Focus Groups><Functional MRI><Functional Magnetic Resonance Imaging><Funding><Future><General Population><General Public><Goals><Group Meetings><Image><Infantile Autism><Inferior Frontal Convolution><Inferior frontal gyrus><Insula><Insula of Reil><Intervention><Intervention Trial><Interventional trial><Interview><Investigators><Island of Reil><Kanner's Syndrome><Knowledge><Language><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Learning><Linguistic><Linguistics><Mediating><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mentors><Methodology><Modeling><NICHD><NIH><National Institute of Child Health and Human Development><National Institutes of Health><Outcomes Research><Parents><Parietal><Participant><Pathway interactions><Pattern><Phase><Phase 1 Clinical Trials><Phase I Clinical Trials><Prevalence><Procedures><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Psychological Health><QOL><Quality of life><Randomized><Randomized, Controlled Trials><Research><Research Personnel><Researchers><Sampling><Scientist><Self Management><Shapes><Socialization><Spanish><Stimulus><Structure><Structure of superior temporal sulcus><Suggestion><Superior Temporal Sulcus><Symptoms><Techniques><Technology><Telemedicine><Testing><Training><Translating><Translational Research><Translational Science><Treatment Efficacy><Treatment outcome><Underserved Population><United States><United States National Institutes of Health><Validation><Work><active followup><adult with ASD><adult with autism><adult with autism spectrum disorder><adult youth><adulthood><adulthood transition><adults on the autism spectrum><adults on the spectrum><autism spectral disorder><autism spectrum disorder><autistic adult><autistic children><autistic spectrum disorder><bilingual><bilingualism><bio-markers><biologic marker><biomarker><career><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical center><clinical intervention><clinical therapy><community advisory board><community advisory committee><community advisory panel><community based participatory research><community health worker><community led research><community participatory research><community partnered participatory research><community partners><community-based partners><cultural values><depression><design><designing><developmental><evidence base><executive control><executive function><experience><fMRI><faces><facial><follow up><follow-up><followed up><followup><imaging><implementation science><improved><individualized therapeutic><innovate><innovation><innovative><insight><interest><intervention efficacy><juvenile><juvenile human><mental illness><multi-modality><multimodality><neural><neural imaging><neural mechanism><neuro-imaging><neuroimaging><neurological imaging><neuromechanism><novel><parent><participant interview><participatory action research><pathway><pediatric><personalized therapeutic><phase I protocol><physical conditioning><physical health><post treatment><programs><psychiatric illness><psychological disorder><psychosocial><randomisation><randomization><randomized control trial><randomized, clinical trials><randomly assigned><recruit><response to therapy><response to treatment><satisfaction><skills><social cognition><social communication><therapeutic efficacy><therapeutic response><therapy efficacy><therapy response><transition from adolescence to adulthood><transition into adulthood><transition to adulthood><translation research><translational investigation><treatment response><treatment responsiveness><trial design><trial regimen><trial treatment><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><validations><young adult><young adult age><young adult with ASD><young adult with autism><young adult with autism spectrum disorder><young adulthood>

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Weikang Shi

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$121,842

FY 2026

Project Title

Cortical-Striatal Circuit Mechanisms Underlying Altruistic Decisions

Grant Number:

1K99MH142687-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project summary Altruistic decisions, the act of benefiting others at a personal cost, are fundamental to social interaction and cooperation. However, the behavioral and neural mechanisms underlying altruistic decisions remain largely underexplored. This project aims to investigate how individuals e...

Research Terms

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Marisa Ann Patti

DREXEL UNIVERSITY, PHILADELPHIA, PA

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$111,199

FY 2026

Project Title

Investigating the Role of Phthalates, Phenols, and Their Sources on Phenotypic Variability in Autism

Grant Number:

1K99ES038217-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/3/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Autism is a neurodevelopmental disorder impacting 1 in 36 children in the US. Children with autism often experience multi-morbidity of other neurodevelopmental disorders (NDDs) and physical health outcomes like obesity and asthma at higher rates than typically developing pee...

Research Terms

<0-11 years old><3 year old><3 years of age><ASD><Address><Asthma><Asthma in Children><Autism><Autism Diagnosis><Autistic Disorder><Award><Biological Markers><Bronchial Asthma><Carbol><Carbolic Acid><Chemical Exposure><Chemicals><Child><Child Health><Child Youth><Childhood Asthma><Children (0-21)><Cognition><Cohort Studies><Data><Data Collection><Data Set><Diet><Early Infantile Autism><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine disrupting agent><Environmental Health><Environmental Health Science><Epidemiology><Exposure to><Frequencies><Funding><Future><General Population><General Public><Gestation><Goals><Grant><Health><Heterogeneity><High Prevalence><Hydroxybenzene><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Investigation><Kanner's Syndrome><Knowledge><Lead><Maternal Exposure><Maternal Nutrition><Maternal diet><Measures><Mediating><Mediation><Mentorship><Multiple types of exposure><NIH><National Institutes of Health><Negotiating><Negotiation><Neighborhoods><Neurodevelopmental Disorder><Neurologic><Neurological><Neurological Development Disorder><Obesity><Outcome><Participant><Pattern><Pb element><Pediatric asthma><Phenols><Phenotype><Population><Pregnancy><Prevalence><Protocol><Protocols documentation><Questionnaires><Research><Research Design><Risk><Risk Reduction><Role><Rural><Sampling><Source><Study Type><Subgroup><Time><Training><United States National Institutes of Health><Urban Health><Urbanicity><Work><adiposity><age 3><age 3 years><autism spectral disorder><autism spectrum disorder><autistic children><autistic spectrum disorder><bio-markers><biologic marker><biomarker><child adiposity><child obesity><childhood adiposity><childhood obesity><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cohort research study><cohort survey><corpulence><data harmonization><dietary><diets><endocrine disrupting compound><epidemiologic><epidemiological><experience><exposed in utero><exposure research><exposure science><fetal exposure><harmonized data><heavy metal Pb><heavy metal lead><improved><in utero exposure><intellectual and developmental disability><intra-uterine environmental exposure><intrauterine environmental exposure><kids><limited intellectual functioning><maternal nutrition during pregnancy><mother nutrition><multi-exposure><multimorbidity><multiple chronic conditions><multiple exposures><multitude of exposure><neurodevelopmental disease><obese children><obesity during childhood><obesity in children><pediatric obesity><peer><personal care products><phthalates><physical conditioning><physical health><prenatal><prenatal exposure><prenatally exposed><programs><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk-reducing><social role><study design><three year old><three years of age><trait><unborn><urban dwelling><urinary><various exposures><various types of exposure><youngster>

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Marcella Birtele

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$90,000

FY 2026

Project Title

Investigating Autism-Related Gut Dysfunction with Human Enteric Neurons and Intestinal Organoids

Grant Number:

1K99DK143293-01A1

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Gastrointestinal (GI) disorders are among the most common comorbidities in patients with Autism Spectrum Disorder (ASD). The Enteric Nervous System (ENS), composed of neurons (ENs) and glia, is crucial in regulating various aspects of gut physiology. Animal models show GI motility im...

Research Terms

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Iryna M Ethell

UNIVERSITY OF CALIFORNIA RIVERSIDE, RIVERSIDE, CA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$482,316

FY 2026

Project Title

Molecular and cellular mechanisms of inhibitory synapse development

Grant Number:

5R01NS129555-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

The goal of the proposed research is to discover new mechanisms underlying the development of hyperactive neuronal networks in the brain. Hyperactivity of neuronal networks due to the loss or impaired function of inhibitory neurons can lead to neural dysfunctions and seizures. Both impaired inhibiti...

Research Terms

<0-11 years old><ASD><Ablation><Abscission><Adhesives><Affect><Ammon Horn><Astrocytes><Astrocytus><Astroglia><Autism><Autistic Disorder><Biochemical><Biochemistry><Biological Chemistry><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><CCK><Cek5 Ligand><Cek5 RPTK Ligand><Cell Body><Cell Communication and Signaling><Cell Locomotion><Cell Migration><Cell Movement><Cell Signaling><Cells><Cellular Migration><Cellular Motility><Child><Child Youth><Children (0-21)><Cholecystokinin><Connector Neuron><Cornu Ammonis><Cues><Cyclic Somatostatin><D Cells><Data><Data Bases><Databases><Delta Cell><Development><Developmental Process><Developmentally Regulated EPH-Related Tyrosine Kinase><Disease><Disorder><Dysfunction><EEG><EFNB1 Gene Product><ELK-Related Tyrosine Kinase><EPH Tyrosine Kinase 2><EPH Tyrosine Kinase 3><EPHB2><EPHB2 gene><EPHT2 Protein><EPHT3><EPTH3><Early Infantile Autism><Efbn2 Gene Product><Electroencephalogram><Electroencephalography><Electrophysiology><Electrophysiology (science)><Elk-L Protein><Encephalon><Encephalon Diseases><Eph Family Receptor Interacting Protein B1><Eph Receptor Ligands><EphB Receptors><EphB1 Protein><EphB1 Receptor><EphB2 Protein><EphB2 Receptor><EphB2-Tyrosine Kinase><Ephrin B Receptor><Ephrin Receptor EphB1><Ephrin Receptor EphB2><Ephrin Type-B Receptor 1><Ephrin Type-B Receptor 2><Ephrin-B1><Ephrin-B2><Ephrins><Epilepsy><Epileptic Seizures><Epileptics><Eplg5 Gene Product><Eplg5 Protein><Equilibrium><ErbB-4><ErbB4><ErbB4 gene><Excision><Excitatory Synapse><Extirpation><Functional disorder><Genes><Genetic study><Goals><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><HER-4><HER4><Hek5><Hippocampus><Human><Hyperactivity><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><In Vitro><Infantile Autism><Inhibitory Synapse><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intervention><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><KI mice><Kanner's Syndrome><Kinases><Knock-in Mouse><Knock-out><Knockout><Knowledge><LERK-2 Protein><LERK-5 Gene Product><LERK-5 Protein><Ligands><Link><Maintenance><Mediating><Mice><Mice Mammals><Microscopy><Modern Man><Molecular><Murine><Mus><NDF/Heregulin Receptor Gene><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Dysfunction><Neuronally Expressed EPH-Related Tyrosine Kinase><Neurons><Neurophysiology / Electrophysiology><Pancreozymin><Parvalbumins><Phosphotransferase Gene><Phosphotransferases><Physiopathology><Predisposition><Publishing><Pyramidal Cells><Pyramidal neuron><Receptor Inhibition><Receptor Protein><Receptor Protein-Tyrosine Kinase HEK5><Receptor Signaling><Removal><Research><Role><SRIH><SRIH-14><Schizophrenia><Schizophrenic Disorders><Seizure Disorder><Seizures><Signal Transduction><Signal Transduction Systems><Signaling><Somatostatin><Somatostatin Cells><Somatostatin Secreting Cell><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><Surgical Removal><Susceptibility><Synapses><Synaptic><TYRO5><Testing><Transphosphorylases><Tyrosine-Protein Kinase Receptor EPH-2><Tyrosine-Protein Kinase Receptor EPH-3><United States><Uropancreozymin><Viral><Visual Cortex><Whole-Cell Recordings><Work><astrocytic glia><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><axon growth cone guidance><axon guidance><balance><balance function><behavior test><behavioral test><biological signal transduction><cell motility><critical developmental period><data base><de novo mutation><de novo variant><dementia praecox><developmental><electrophysiological><elk Ligand><epilepsia><epilepsy monitoring><epilepsy recording><epilepsy tracking><epileptic monitoring><epileptic recording><epileptiform monitoring><epileptiform recording><epileptiform tracking><epileptogenic><epileptogenic monitoring><gain of function><growth hormone release inhibiting factor><hippocampal><hippocampal pyramidal neuron><imaging approach><imaging based approach><in vivo><inhibitory neuron><innervation><kids><knockin mice><loss of function><mouse model><murine model><nerve supply><neural cell body><neural dysfunction><neurodevelopmental disease><neuronal><neuronal cell body><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><optogenetics><overexpress><overexpression><pathophysiology><prevent><preventing><receptor><resection><response><schizophrenic><seizure detection><seizure monitoring><seizure recording><seizure tracking><social role><soma><synapse><synapse formation><synaptogenesis><visual cortical><youngster>

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Andrew C. Liu

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 52/100

Likely hiring

Solid budget

Active award

$468,699

FY 2026

Project Title

Role of mTOR in Circadian and Sleep Deregulation in Smith-Kingsmore Syndrome (SKS)

Grant Number:

5R01NS117457-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT Smith-Kingsmore Syndrome (SKS) is a newly discovered genetic disorder caused by mutations in the mechanistic target of rapamycin (MTOR) gene. MTOR functions to coordinate intracellular energy levels with cellular homeostasis and growth. MTOR deregulation is implicated in various pathologica...

Research Terms

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MOLLIE Katherine MEFFERT

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 52/100

Likely hiring

Solid budget

Active award

$467,827

FY 2026

Project Title

Defining post-transcriptional gene regulation in FMRP-deficiency usingmiRNA:target chimeras

Grant Number:

5R01MH129292-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Fragile X Syndrome (FXS) is the most common monogenic cause of Autism spectrum disorder (ASD), a group of complex neurodevelopmental disorders characterized by core diagnostic impairments in social interactions and communication, restricted repetitive behaviors and interests, and an association with...

Research Terms

<0-11 years old><ASD><Affect><Autism><Autistic Disorder><Behavioral><Binding Proteins><Biochemical><Biogenesis><Brain><Brain Nervous System><CNS Nervous System><Cell Communication and Signaling><Cell Signaling><Central Nervous System><Child><Child Youth><Children (0-21)><Chimera><Chimera organism><Closure by Ligation><Cognitive><Complex><Coupling><Data><Data Set><Degenerative Neurologic Disorders><Detection><Development><Diagnostic><Dysfunction><ERK 1><ERK1><ERK1 Kinase><Early Infantile Autism><Encephalon><Escalante syndrome><Extracellular Signal-Regulated Kinase 1><Extracellular Signal-Regulated Kinase Gene><FMR-1 Protein><FMR1 Protein><FMR1 gene><FMRP><FMRP protein><FRAXA><Family><Fragile X><Fragile X Mental Retardation 1 Gene><Fragile X Mental Retardation Protein><Fragile X Syndrome><Functional RNA><Functional disorder><Gene Action Regulation><Gene Down-Regulation><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Targeting><Generalized Growth><Genes><Genetic Diseases><Goals><Growth><High-Throughput Nucleotide Sequencing><High-Throughput Sequencing><Human><Hyperactivity><Immune Precipitation><Immunoprecipitation><Impairment><Incidence><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Intracellular Communication and Signaling><Investigation><KO mice><Kanner's Syndrome><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><Ligand Binding Protein><Ligand Binding Protein Gene><Ligation><Link><MAP Kinase 3><MAP Kinase Gene><MAPK><MAPK3><MAPK3 Mitogen-Activated Protein Kinase><MAPK3 gene><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Mediating><Messenger RNA><Mice><Mice Mammals><MicroRNAs><Mitogen-Activated Protein Kinase 3><Mitogen-Activated Protein Kinase 3 Gene><Mitogen-Activated Protein Kinase Gene><Modern Man><Molecular><Molecular Target><Morphology><Motivation><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuranatomies><Neuranatomy><Neuraxis><Neuroanatomies><Neuroanatomy><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurodevelopmental Disorder><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Development Disorder><Neurological Disorders><Neurons><Noncoding RNA><Nontranslated RNA><Null Mouse><Origin of Life><P44ERK1><PSTkinase p44mpk><Pathway interactions><Patients><Phenotype><Physiopathology><Post-Transcriptional Control><Post-Transcriptional Regulation><Production><Protein Binding><Protein Biosynthesis><Protein Deficiency><Proteins><RISC Multicomponent Nuclease><RNA Binding><RNA bound><RNA-Binding Proteins><RNA-Induced Silencing Complex><Regulatory Protein><Renpenning syndrome 2><Repression><Resistance><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Signal Transduction><Signal Transduction Systems><Signaling><Social Interaction><Specificity><Synapses><Synaptic><Techniques><Testing><Time><Tissue Growth><Transcript><Transcription Repression><Translations><Untranslated RNA><Validation><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><autism spectral disorder><autism spectrum disorder><autism-fragile X (AFRAX) syndrome><autistic spectrum disorder><behavior phenotype><behavioral phenotyping><biological signal transduction><bound protein><brain abnormalities><cell type><chimeras><cognitive function><crosslink><deficiency of protein><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><excitatory neuron><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X FMR1 protein><fragile X mental retardation 1><fragile X mental retardation-1 protein><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><gene repression><genetic condition><genetic disorder><genetic regulatory protein><genome scale><genome-wide><genomewide><human model><human progenitor cell derived><human stem cell-derived><iPS><iPSC><iPSCs><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intellectual and developmental disability><interest><kids><limited intellectual functioning><mRNA><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><miRNA><model of human><modulator protein><mouse model><murine model><neural><neurodegenerative illness><neurodevelopmental disease><neurological disease><neuronal><neuronal growth><noncoding><ontogeny><p44 MAPK><pathophysiology><pathway><phosphatase inhibitor 2><phosphoprotein phosphatase inhibitor-2><post-transcriptional gene regulation><posttranscriptional><programs><protein function><protein phosphatase inhibitor-2><protein synthesis><regulatory gene product><repetitive behavior><resistant><restoration><social communication><synapse><translation><validations><youngster>

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Melissa Lynne Caras

UNIV OF MARYLAND, COLLEGE PARK, COLLEGE PARK, MD

Good lead · 52/100

Likely hiring

Solid budget

Active award

$463,507

FY 2026

Project Title

Non-sensory Circuits for Auditory Perceptual Learning

Grant Number:

5R01DC020742-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Training can sharpen and refine our perceptual skills. In the auditory system, this process— termed perceptual learning— shapes the acquisition of both native and non-native languages, and can improve speech and music recognition in users of assisted listening devices. Previous work ...

Research Terms

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Damaris N Lorenzo

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$442,099

FY 2026

Project Title

Elucidating the synaptic interactome of the high risk autism gene ANK2

Grant Number:

5R01MH127848-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Network gene analysis suggests that high confidence autism spectrum disorder (hcASD) genes operate through convergent mechanisms that predominantly support synaptic function, which, in turn, can determine anatomical and functional brain connectivity. Several variants in ANK2 have bee...

Research Terms

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Holly Annette Feser Stessman

CREIGHTON UNIVERSITY, OMAHA, NE

Good lead · 52/100

Likely hiring

Solid budget

Active award

$434,507

FY 2026

Project Title

Epigenetic regulation of the neuroendocrine axis in brain development and behavior

Grant Number:

5R01MH133600-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/15/2024

End Date:

10/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Lysine methyltransferase 5B (KMT5B) is part of a gene family that modulates the methylation state of histone 4 lysine 20 (H4K20) residues, and H4K20 methylation regulates gene expression by altering chromatin compaction. Heterozygous disruptive variants in KMT5B have been associated ...

Research Terms

<21+ years old><ASD><ASD patient><ATAC><ATAC sequencing><ATAC-seq><ATACseq><Address><Adult><Adult Human><Allelic Loss><Animals><Anxiety><Assay for Transposase-Accessible Chromatin using sequencing><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Automobile Driving><BBB crossing><Behavior><Behavioral><Birth Defects><Body Size><Body Tissues><Brain><Brain Nervous System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chromatin><Classification><Clinical><Clinical Treatment><Cognition><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Data><Decreased Muscle Tone><Development><Developmental Delay><Developmental Delay Disorders><EC 2.1.1><Early Infantile Autism><Embryo><Embryonic><Encephalon><Endocrine><Endocrine Gland Secretion><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><FDA approved><Family><Fear><Feedback><Fright><Gene Action Regulation><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Expression Regulation><Gene Family><Gene Regulation><Gene Regulation Process><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Germ Lines><Growth><Growth Agents><Growth Factor><Growth Factor Gene><Growth Factor Interaction><Growth Factor Overexpression><Growth Factor Proto-Oncogene><Growth Substances><Heterozygote><Histones><Hormones><Human><Hypomyotonia><Hypotonia><IGF-2><IGF-II><IGF1><IGF1 gene><IGF2><IGF2 gene><IGFI><Infantile Autism><Insulin-Like Growth Factor 2><Insulin-Like Growth Factor II><Insulin-Like Growth Factors><Insulin-Like Somatomedin Peptide II><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intracellular Communication and Signaling><KO mice><Kanner's Syndrome><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><L-Lysine><LPTN><Learning><Link><Liver><Loss of Heterozygosity><Lysine><Macrocephaly><Megacephaly><Megalocephaly><Messenger RNA><Methylation><Methyltransferase><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Multiplication-Stimulating Activity><Multiplication-Stimulating Factor><Murine><Mus><Muscle Hypotony><Muscle Tone Poor><Muscle Tonus><Muscle hypotonia><Muscular Hypotonia><Mutate><Neurodevelopmental Disorder><Neuroendocrine><Neuroendocrine System><Neurologic><Neurological><Neurological Development Disorder><Neurosecretory Systems><Null Mouse><Outcome><Outcome Study><Paracrine Communication><Paracrine Signaling><Pathway interactions><Patients><Pattern><Phase 2 Clinical Trials><Phase II Clinical Trials><Phenotype><Play><Population><Production><Proteins><Proteins Growth Factors><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Reporting><Research Resources><Resources><Role><SCM-1><SCM-1a><SCM1><SCYC1><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal Muscle><Somatomedin A><Somatomedin MSA><Somatomedins><Specific Child Development Disorders><Specific qualifier value><Specified><Sulfation Factor><Supplementation><System><Systematics><Testing><Therapeutic><Therapeutic Hormone><Time><Tissue Growth><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Variant><Variation><Voluntary Muscle><Weight><XCL1><XCL1 gene><adulthood><analyze gene expression><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><autism spectral disorder><autism spectrum disorder><autistic patient><autistic spectrum disorder><behavior phenotype><behavioral phenotyping><biological signal transduction><blood-brain barrier crossing><bloodbrain barrier crossing><brain cell><cell type><clinical intervention><clinical therapy><defined contribution><developmental><driving><druggable target><epigenetic regulation><epigenetically><gene expression analysis><gene expression assay><hepatic body system><hepatic organ system><heterozygosity><insulin regulation><insulinlike growth factor><intellectual and developmental disability><limited intellectual functioning><loss of function><mRNA><mRNA Expression><member><methylase><mouse model><multidisciplinary><multiomics><multiple omics><murine model><muscle tone><neurodevelopmental disease><neurotrophic factor><neurotrophin><neutrophin><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><ontogeny><panomics><paracrine><pathway><patient population><patient with ASD><phase II protocol><postnatal><social><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic development><therapeutic target><transcriptional profiling><transcriptome sequencing><transcriptomic sequencing><transmethylase><trial regimen><trial treatment><weights>

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Natalia Vanesa De Marco Garcia

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Good lead · 52/100

Likely hiring

Solid budget

Active award

$423,750

FY 2026

Project Title

Neural Mechanism for the assembly of GABAergic in the cerebral cortex

Grant Number:

5R01MH110553-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2016

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Dysfunction of gamma-aminobutyric acid (GABA)ergic interneurons is strongly associated with neurological disorders including epilepsy, schizophrenia and autism spectrum disorders. Although recent evidence highlights bewildering subtype diversity of these neurons, the notion that deve...

Research Terms

<2-photon><21+ years old><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><ASD><ASD patient><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Aminalon><Aminalone><Area><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Behavior><Behavioral><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Calcium><Causality><Cell Body><Cells><Cerebral cortex><Chemotactic Cytokines><Column of Bertini><Connector Neuron><Cortical Column><Defect><Development><Developmental Process><Disease><Disorder><Distal><Dysfunction><Early Infantile Autism><Emergencies><Emergency Situation><Encephalon><Encephalon Diseases><Epilepsy><Epileptic Seizures><Epileptics><Equilibrium><Etiology><Functional disorder><GABA><Goals><Homologous Chemotactic Cytokines><Human><Image><Impairment><In vivo two-photon calcium imaging><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Intercrines><Interneuron function><Interneurons><Internuncial Cell><Internuncial Neuron><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><Laser Electromagnetic><Laser Radiation><Lasers><Lateral><Lead><Ligands><Mice><Mice Mammals><Microscopy><Modern Man><Murine><Mus><Mutant Strains Mice><Neonatal><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic Disorders><Neurological Disorders><Neurons><Outcome><Output><Pb element><Perinatal><Peripartum><Photons><Physiopathology><Population><Process><Pyramidal neuron><Renal Column of Bertini><Research><Rest><Role><SIS cytokines><Scanning><Schizophrenia><Schizophrenic Disorders><Seizure Disorder><Sensory><Sensory Deprivation><Shapes><Somatosensory Cortex><Study models><System><Techniques><Testing><Thalamic structure><Thalamus><Vibrissae><Whiskers><Work><adulthood><autism spectral disorder><autism spectrum disorder><autistic patient><autistic spectrum disorder><balance><balance function><barrel cortex><brain abnormalities><causation><chemoattractant cytokine><chemokine><childhood epilepsy><critical period><dementia praecox><developmental><disease causation><epilepsia><epileptogenic><excitatory neuron><gamma-Aminobutyric Acid><genetic approach><genetic strategy><heavy metal Pb><heavy metal lead><hippocampal pyramidal neuron><imaging><in vivo><in vivo calcium imaging><inhibitory neuron><innovate><innovation><innovative><insight><juvenile><juvenile human><maladaptive behavior><mouse mutant><neonate><neural mechanism><neurological disease><neurological pathology><neuromechanism><neuronal><neurotrophic factor><neurotrophin><neutrophin><pathophysiology><patient with ASD><pediatric epilepsy><perinatal development><post-natal development><postnatal><postnatal development><pup><recruit><schizophrenic><sensor><sensory integration><social role><somatosensory><somesthetic sensory cortex><thalamic><translational impact><two-photon><γ-Aminobutyric Acid>

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Hua Yan

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 52/100

Likely hiring

Solid budget

Active award

$419,457

FY 2026

Project Title

Neuroplasticity in chemosensory-mediated social behaviors

Grant Number:

5R01DC020203-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Summary During development and throughout adulthood, humans display strong neuroplasticity, the capacity of adaptive changes of neurons and neural circuits in response to social environments. Plasticity in chemosensory system is essential for learning and memory, social communication and quality of...

Research Terms

<21+ years old><AD dementia><ASD><Address><Adult><Adult Human><Afferent Neurons><Age><Aggression><Aggressive behavior><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Animal Model><Animal Models and Related Studies><Animals><Anosmia><Ants><Apoptosis><Apoptosis Pathway><Autism><Autistic Disorder><Behavior><Brain><Brain Nervous System><CNS plasticity><Caspase><Caspase Gene><Cell Body><Cell Death><Cell-Death Protease><Cells><Complex><Cysteine Endopeptidases><Cysteine Protease><Cysteine Proteinases><DNA mutation><Defect><Dendrites><Development><Differential Display><Drosophila><Drosophila genome><Drosophila genus><Early Infantile Autism><Encephalon><FISH Technic><FISH Technique><FISH analysis><FISH assay><Failure><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><Gene Expression><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genome><Human><ICE-like protease><Immune Response Genes><In Situ Nick-End Labeling><Infantile Autism><Insecta><Insects><Insects Invertebrates><Ir Gene><Kanner's Syndrome><Lead><Learning><Lobe><Mammalia><Mammals><Mediating><Memory><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Development><Neural Receptors><Neurocyte><Neurologic Disorders><Neurological Disorders><Neuronal Plasticity><Neurons><Neuroreceptors><Nurses><Odor Receptor Protein><Odorant Receptor Proteins><Odorant Receptors><Odors><Olfaction><Olfactory Receptor Proteins><Organism><Paralysis Agitans><Parkinson><Parkinson Disease><Partner in relationship><Pattern><Pb element><Primary Parkinsonism><Primary Senile Degenerative Dementia><Programmed Cell Death><QOL><Quality of life><RNA Seq><RNA sequencing><RNAseq><Reaction><Receptor Gene><Receptor Protein><Role><Schizophrenia><Schizophrenic Disorders><Sensory><Sensory Neurons><Sensory Receptors><Series><Shapes><Smell><Smell Perception><Social Behavior><Social Environment><Social isolation><Staining method><Stains><Structure><System><TUNEL><Testing><Time><adulthood><ages><anosphrasia><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><central nervous system plasticity><cystein protease><cystein proteinase><cysteine endopeptidase><dementia praecox><developmental><differential display technique><experiment><experimental research><experimental study><experiments><fruit fly><fruit fly genome><genome mutation><global gene expression><global transcription profile><heavy metal Pb><heavy metal lead><injury recovery><living system><lobes><loss of smell><mRNA Differential Displays><mate><model of animal><mutant><necrocytosis><nerve cell death><nerve cell loss><neural circuit><neural circuitry><neural plasticity><neurocircuitry><neurodevelopment><neurological disease><neuron cell death><neuron cell loss><neuron death><neuron development><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal circuit><neuronal circuitry><neuronal death><neuronal development><neuronal loss><neuronal survival><neuroplastic><neuroplasticity><novel><nurse><odor perception><olfactory bulb><olfactory loss><olfactory perception><primary degenerative dementia><receptor><receptor expression><recovery after injury><recovery following injury><recovery post injury><response><scRNA sequencing><scRNA-seq><schizophrenic><senile dementia of the Alzheimer type><sensory system><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social><social climate><social communication><social context><social defects><social deficits><social disorders><social dysfunction><social role><sociobehavior><sociobehavioral><socioenvironment><socioenvironmental><synaptic circuit><synaptic circuitry><terminal nick end labeling><tool><trafficking><transcriptome><transcriptome sequencing><transcriptomic sequencing>

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peng zhang

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

Good lead · 52/100

Likely hiring

Solid budget

Active award

$418,262

FY 2026

Project Title

The role of heparan sulfate modification on neurexin1 in synapse development

Grant Number:

5R01MH130476-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Proper synaptic function relies on a dedicated assembly of pre- and postsynaptic proteins. Neurexin1 is a principal presynaptic organizing protein essential for synaptic function. Mammalian neurexin1 has three isoforms (α, β, and γ). While neurexin1α and β have laminin/neurexin/sex hormone (LNS) dom...

Research Terms

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Nicole Gabriele Coufal

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$408,929

FY 2026

Project Title

The Contribution of Microglial MEF2C to Brain Development

Grant Number:

5R01NS124637-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Summary/Abstract Intellectual disability and autism spectrum disorders are devastating disorders thought to arise from a combination of synaptic dysfunction and altered neural progenitor modulation for which there are no effective treatments. Mutations or deletions in one allele of myocyte enhancer ...

Research Terms

<0-11 years old><ASD><Affect><Aging><Alleles><Allelomorphs><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Autism><Autistic Disorder><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Basal Transcription Factor><Basal transcription factor genes><Behavioral><Behavioral Assay><Biologic Models><Biological Models><Brain><Brain Nervous System><CRISPR><CRISPR/Cas system><CSIF><CSIF-10><Cell Body><Cells><Cerebrum><ChIP assay><Child><Child Development Disorders><Child Youth><Childhood><Children (0-21)><Chromosomal microdeletion><Clustered Regularly Interspaced Short Palindromic Repeats><Co-culture><Cocultivation><Coculture><Coculture Techniques><Communication><Cytokine Synthesis Inhibitory Factor><DNA mutation><Data><Data Set><Dependence><Development><Developmental Disabilities><Diagnosis><Disease><Disorder><Drug Screening><Drug Therapy><Drug Utilization><Dysfunction><Early Infantile Autism><Encephalon><Engraftment><Enhancers><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Fore-Brain><Forebrain><Functional disorder><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genomics><Goals><HPGF><Hepatocyte-Stimulating Factor><Heterozygote><Hortega cell><Human><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-10><IL-6><IL10><IL10A><IL6 Protein><Immunity><Impairment><In Vitro><Infantile Autism><Inflammation Mediators><Inflammatory><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Interleukin 10 Precursor><Interleukin-10><Interleukin-6><Kanner's Syndrome><Knowledge><Life><Link><MEF-2><MEF-2C><MEF2C protein><MGI-2><Macrophage><Maps><Measurement><Measures><Mediating><Methods><Mice><Mice Mammals><Microglia><Mission><Model System><Modeling><Modern Man><Murine><Mus><Mutation><Myeloid Differentiation-Inducing Protein><Mφ><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neural Stem Cell><Neurocyte><Neurodevelopmental Deficit><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Organoids><Outcome><Pathogenesis><Pathology><Pathway interactions><Phagocytosis><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiopathology><Plasmacytoma Growth Factor><Preclinical data><Prosencephalon><Public Health><RNA Expression><Regulation><Reporting><Research><Role><Science><Social Behavior><Social Interaction><Stimulus><Synapses><Synaptic><Syndrome><System><Techniques><Testing><Therapeutic><Thick><Thickness><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><United States><United States National Institutes of Health><autism spectral disorder><autism spectrum disorder><autistic children><autistic spectrum disorder><behavior phenotype><behavioral phenotyping><cell type><cerebral><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><chromatin immunoprecipitation><decrease disability><decrease in disability><density><developmental><disability reduction><drug intervention><drug treatment><effective therapy><effective treatment><epigenetically><gene network><genome mutation><gitter cell><glial cell development><glial development><glial neural stem cell><glial progenitor><glial stem cell><heterozygosity><human data><iPS><iPSC><iPSCs><improved outcome><in vivo><in vivo Model><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inflammatory mediator><insight><intellectual and developmental disability><interferon beta 2><kids><lessen disability><limited intellectual functioning><mef2 protein><mesoglia><microdeletion><microglial cell><microgliocyte><migration><minimize disability><mitigate disability><motor behavior><muscle-specific enhancer factor-2><myocyte enhancer factor 2><myocyte enhancer factor 2C><myocyte-specific enhancer-binding factor 2><myocyte-specific enhancer-binding-factor 2C><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopment><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neuroglial progenitor><neuroglial stem cells><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathophysiology><pathway><pediatric><perivascular glial cell><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pre-clinical><preclinical><preclinical findings><preclinical information><progenitor and neural stem cells><progenitor cell model><progenitor cell pool><progenitor cell population><progenitor model><progenitor pool><progenitor population><reduction in disability><response><slow disability><social><social defects><social deficits><social disorders><social dysfunction><social role><sociobehavior><sociobehavioral><stem and progenitor cell model><stem and progenitor cell population><stem cell based model><stem cell derived model><stem cell model><stem cell pool><stem cell population><synapse><synaptic pruning><therapeutic target><transcription factor><transcriptomics><youngster>

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Katherine Tschida

CORNELL UNIVERSITY, ITHACA, NY

Good lead · 52/100

Likely hiring

Solid budget

Active award

$399,897

FY 2026

Project Title

Neural Circuits for Context-Dependent Control of Vocal Communication

Grant Number:

5R01MH136887-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Vocal communication is essential for human social relationships, and deficits in vocal communication that characterize autism spectrum disorder (ASD) have devastating impacts on the affected individuals and on society. Despite the importance of vocalization to social behavio...

Research Terms

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Hongkyun Kim

ROSALIND FRANKLIN UNIV OF MEDICINE & SCI, NORTH CHICAGO, IL

Good lead · 52/100

Likely hiring

Solid budget

Active award

$396,015

FY 2026

Project Title

Molecular and cellular regulation of CaV2 voltage-gated calcium channels

Grant Number:

1R01NS142163-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

CaV2 voltage-gated calcium channels mediate calcium influx at presynaptic axon terminals, triggering neurotransmitter release. Genetic variants in CaV2 channels are associated with multiple neurological and neurodevelopmental conditions, including ataxia, seizures, and autism. CaV2 channel levels ar...

Research Terms

<APF-1><ASD><ATP-Dependent Proteolysis Factor 1><Abscission><Adaptor Protein><Adaptor Protein Gene><Adaptor Signaling Protein><Adaptor Signaling Protein Gene><Animals><Ataxia><Ataxy><Autism><Autistic Disorder><Axon Terminals><Binding><Biology><C elegans><C. elegans><C.elegans><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Caenorhabditis elegans><Calcium><Calcium Channel><Calcium Channel Antagonist Receptor><Calcium Channel Blocker Receptors><Calcium Ion Channels><Cas nuclease technology><Cellular Regulation><Characteristics><Class I Genes><Class II Genes><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Compensation><Coordination Impairment><Cyclicity><DNA mutation><Data><Defect><Detection><Deubiquitination><Disease><Disorder><Dysfunction><Dyssynergia><E3 Ligase><E3 Ubiquitin Ligase><Early Infantile Autism><Ego><Endocytic Vesicle><Endocytosis><Endocytotic Vesicle><Endosomes><Epilepsy><Epileptic Seizures><Epileptics><Excision><Exhibits><Extirpation><Familial Hemiplegic Migraine><Functional disorder><Gene variant><GeneHomolog><Genes><Genetic><Genetic Change><Genetic Models><Genetic Screening><Genetic defect><Genetic mutation><Goals><HLA Class II Genes><HMG-20><HUMORF8 Gene><High Mobility Protein 20><Homolog><Homologous Gene><Homologue><HumORF8><Impairment><Infantile Autism><Injury><KIAA0055><Kanner's Syndrome><Knowledge><Link><MHC Class I><MHC Class I Genes><MHC Class II><MHC Class II Genes><Mammalia><Mammals><Measurable><Mediating><Modeling><Molecular><Molecular Interaction><Movement><Mutation><Neck><Nematoda><Nematodes><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Transmission><Neurocyte><Neurodevelopmental Disorder><Neurologic><Neurologic Disorders><Neurological><Neurological Development Disorder><Neurological Disorders><Neurons><Ortholog><Orthologous Gene><Outcome Study><Pathologic><Pathway interactions><Periodicity><Physiopathology><Presynaptic Nerve Endings><Presynaptic Terminals><Process><Proteins><Receptosomes><Regulation><Removal><Research Resources><Resources><Rhythmicity><Role><Seizure Disorder><Seizures><Structure><Surgical Removal><Synapses><Synaptic><Synaptic Boutons><Synaptic Terminals><Synaptic Transmission><Synaptic Vesicles><Testing><Therapeutic><UBPY><USP8><USP8 gene><Ubiquitilation><Ubiquitin><Ubiquitin Protein Ligase><Ubiquitin Specific Protease 8 Gene><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><VDCC><Vertebrate Animals><Vertebrates><Voltage-Dependent Calcium Channels><Work><adapter protein><allelic variant><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><base><bases><body movement><cell growth regulation><cell type><de-ubiquitinase><de-ubiquitinating enzyme><druggable target><epilepsia><epileptogenic><forward genetics><genetic analysis><genetic approach><genetic strategy><genetic variant><genome editing><genome mutation><genomic editing><genomic variant><injuries><innovate><innovation><innovative><insight><mutant><neurodevelopmental disease><neurological disease><neuronal><neurotransmitter release><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathophysiology><pathway><presynaptic><recruit><resection><roundworm><social role><synapse><therapeutic target><trafficking><ubiquination><ubiquitin conjugation><ubiquitin isopeptidase><ubiquitin-protein ligase><ubiquitin-specific isopeptidase><vertebrata><voltage>

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Janet E Richmond

ROSALIND FRANKLIN UNIV OF MEDICINE & SCI, NORTH CHICAGO, IL

Good lead · 52/100

Likely hiring

Solid budget

Active award

$396,015

FY 2026

Project Title

Molecular and cellular regulation of CaV2 voltage-gated calcium channels

Grant Number:

1R01NS142163-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

CaV2 voltage-gated calcium channels mediate calcium influx at presynaptic axon terminals, triggering neurotransmitter release. Genetic variants in CaV2 channels are associated with multiple neurological and neurodevelopmental conditions, including ataxia, seizures, and autism. CaV2 channel levels ar...

Research Terms

<APF-1><ASD><ATP-Dependent Proteolysis Factor 1><Abscission><Adaptor Protein><Adaptor Protein Gene><Adaptor Signaling Protein><Adaptor Signaling Protein Gene><Animals><Ataxia><Ataxy><Autism><Autistic Disorder><Axon Terminals><Binding><Biology><C elegans><C. elegans><C.elegans><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Caenorhabditis elegans><Calcium><Calcium Channel><Calcium Channel Antagonist Receptor><Calcium Channel Blocker Receptors><Calcium Ion Channels><Cas nuclease technology><Cellular Regulation><Characteristics><Class I Genes><Class II Genes><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Compensation><Coordination Impairment><Cyclicity><DNA mutation><Data><Defect><Detection><Deubiquitination><Disease><Disorder><Dysfunction><Dyssynergia><E3 Ligase><E3 Ubiquitin Ligase><Early Infantile Autism><Ego><Endocytic Vesicle><Endocytosis><Endocytotic Vesicle><Endosomes><Epilepsy><Epileptic Seizures><Epileptics><Excision><Exhibits><Extirpation><Familial Hemiplegic Migraine><Functional disorder><Gene variant><GeneHomolog><Genes><Genetic><Genetic Change><Genetic Models><Genetic Screening><Genetic defect><Genetic mutation><Goals><HLA Class II Genes><HMG-20><HUMORF8 Gene><High Mobility Protein 20><Homolog><Homologous Gene><Homologue><HumORF8><Impairment><Infantile Autism><Injury><KIAA0055><Kanner's Syndrome><Knowledge><Link><MHC Class I><MHC Class I Genes><MHC Class II><MHC Class II Genes><Mammalia><Mammals><Measurable><Mediating><Modeling><Molecular><Molecular Interaction><Movement><Mutation><Neck><Nematoda><Nematodes><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Transmission><Neurocyte><Neurodevelopmental Disorder><Neurologic><Neurologic Disorders><Neurological><Neurological Development Disorder><Neurological Disorders><Neurons><Ortholog><Orthologous Gene><Outcome Study><Pathologic><Pathway interactions><Periodicity><Physiopathology><Presynaptic Nerve Endings><Presynaptic Terminals><Process><Proteins><Receptosomes><Regulation><Removal><Research Resources><Resources><Rhythmicity><Role><Seizure Disorder><Seizures><Structure><Surgical Removal><Synapses><Synaptic><Synaptic Boutons><Synaptic Terminals><Synaptic Transmission><Synaptic Vesicles><Testing><Therapeutic><UBPY><USP8><USP8 gene><Ubiquitilation><Ubiquitin><Ubiquitin Protein Ligase><Ubiquitin Specific Protease 8 Gene><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><VDCC><Vertebrate Animals><Vertebrates><Voltage-Dependent Calcium Channels><Work><adapter protein><allelic variant><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><base><bases><body movement><cell growth regulation><cell type><de-ubiquitinase><de-ubiquitinating enzyme><druggable target><epilepsia><epileptogenic><forward genetics><genetic analysis><genetic approach><genetic strategy><genetic variant><genome editing><genome mutation><genomic editing><genomic variant><injuries><innovate><innovation><innovative><insight><mutant><neurodevelopmental disease><neurological disease><neuronal><neurotransmitter release><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathophysiology><pathway><presynaptic><recruit><resection><roundworm><social role><synapse><therapeutic target><trafficking><ubiquination><ubiquitin conjugation><ubiquitin isopeptidase><ubiquitin-protein ligase><ubiquitin-specific isopeptidase><vertebrata><voltage>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Mark Joseph Daly

BROAD INSTITUTE, INC., CAMBRIDGE, MA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$392,517

FY 2026

Project Title

2/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder

Grant Number:

5R01MH129722-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract The past decade has seen outstanding advances in the genetics of autism spectrum disorder (ASD). Most of this progress has occurred by the study of rare genetic variation, especially de novo variation, with the Autism Sequencing Consortium (ASC) playing a central role. The A...

Research Terms

<1st trimester><21+ years old><ANK2><ANK2 gene><ASD><Acceleration><Adult><Adult Human><Affect><Ankyrin 2><Ankyrin-B><Autism><Autistic Disorder><Brain Ankyrin><Brain Diseases><Brain Disorders><Cell Communication and Signaling><Cell Signaling><Clinical><Copy Number Polymorphism><DNA mutation><Data><Development><Diagnosis><Disease><Disorder><Early Infantile Autism><Early Placental Phase><Encephalon Diseases><Family><First Pregnancy Trimester><First Trimester><Foundations><General Population><General Public><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Risk><Genetic Variation><Genetic defect><Genetic mutation><Goals><Hereditary><Heterogeneity><Individual><Infantile Autism><Inherited><International><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><Learning><Link><Mental disorders><Mental health disorders><Methods><Missense Mutation><Mission><Mutation><NIH><National Institutes of Health><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Ankyrin><Nonerythroid Ankyrin><Nucleotides><Outcome><Pathogenesis><Pathway interactions><Pattern><Play><Population><Prevention><Process><Psychiatric Disease><Psychiatric Disorder><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><RFX3><Recommendation><Research><Research Grants><Research Project Grants><Research Projects><Research Resources><Resources><Risk><Risk-associated variant><Role><SEQ-AN><Sampling><Sequence Analyses><Sequence Analysis><Signal Transduction><Signal Transduction Systems><Signaling><Site><Source><Statistical Methods><Symptoms><TOPMed><Trans-Omics for Precision Medicine><Transmission><United States National Institutes of Health><Variant><Variation><adulthood><analytical method><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><biological signal transduction><cell type><cohort><copy number variant><copy number variation><developmental><developmental disease><developmental disorder><discover genes><disease risk><disorder risk><entire genome><exome><full genome><functional genomics><gain of function><gene discovery><genetic architecture><genome mutation><genomic data><genomic dataset><improved><indel><innovate><innovation><innovative><insertion/deletion><insertion/deletion mutation><insight><loss of function><low-frequency mutation><mental illness><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><neurodevelopmental disease><neuropsychiatric disease><neuropsychiatric disorder><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><population based><psychiatric illness><psychological disorder><rare allele><rare mutation><rare variant><repetitive behavior><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sex><social defects><social deficits><social disorders><social dysfunction><social role><statistic methods><therapeutic target><transmission process><whole genome>

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Lauren Lynn Orefice

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$391,467

FY 2026

Project Title

Development, Function, and Dysfunction of Gastrointestinal Tract-Innervating Dorsal Root Ganglia Neurons in Autism Spectrum Disorder

Grant Number:

5R01NS126691-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary: Autism spectrum disorders (ASDs) are prevalent developmental disorders, defined by impairments in social interactions and communication as well as restricted, repetitive behaviors. The majority of individuals with ASD exhibit a range of co-morbid symptoms, including gastrointestinal...

Research Terms

<0-11 years old><ASD><Afferent Neurons><Ailmentary System><Alimentary Canal><Alimentary System><Anatomic Sites><Anatomic structures><Anatomy><Anxiety><Assay><Autism><Autistic Disorder><Autonomic pain><Axon><Behavior-Related Disorder><Behavior-Related Problem><Bioassay><Biological Assay><Brain><Brain Nervous System><Brain Stem><Brainstem><CNS Nervous System><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Child><Child Youth><Children (0-21)><Chronic><Colon><Colon or Rectum><Colorectal><Conscious><Consciousness><Cranial Nerve X><DNA mutation><Data><Development><Digestive System><Digestive Tract><Dorsal Root Ganglia><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Environment><Environmental Factor><Environmental Risk Factor><Esthesia><Etiology><Exhibits><Extremities><Functional disorder><GI Tract><GI microbiome><Gastrointestinal Body System><Gastrointestinal Motility><Gastrointestinal Organ System><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Alteration><Gene Mutation><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Histology><Impairment><In Vitro><Infantile Autism><Intracellular Communication and Signaling><Kanner's Syndrome><Lead><Lifestyle-Related Disorder><Lifestyle-Related Problem><Lifestyle-related condition><Light><Limb structure><Limbs><Link><MeCP-2 protein><MeCP2><MeCP2 protein><Measures><Mechanics><Medulla Spinalis><Methyl CpG binding protein MeCP2><Methyl-CpG-Binding Protein 2><Methyl-DNA binding protein MECP2><Mice><Mice Mammals><Modality><Murine><Mus><Mutation><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Dysfunction><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Nodose Ganglion><Non-Trunk><Pain><Painful><Pathology><Pathway interactions><Patients><Pb element><Peripheral><Permeability><Phenotype><Photoradiation><Physiopathology><Pneumogastric Nerve><Population><Prevalence><Process><Property><Rectum><Reflex><Reflex action><Reporting><Role><Sensation><Sensory><Sensory Neurons><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Site><Skin><Social Behavior><Social Interaction><Spinal><Spinal Cord><Spinal Ganglia><Stereotyped Behavior><Stretching><Tactile><Tenth Cranial Nerve><Testing><Touch><Touch sensation><Unconscious><Unconscious State><Unconsciousness><Vagus Nerve><Vagus nerve structure><Viscera><Visceral pain><Withdrawal><Work><alimentary tract><alleviate symptom><alter microbiome><ameliorating symptom><anxiety-like behavior><associated symptom><autism attributes><autism indicator><autism model><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><axon signaling><axon-glial signaling><axonal signaling><biological signal transduction><causation><co-morbid symptom><co-occuring symptom><colorectum><comorbid symptom><concurrent symptom><consciousness loss><cooccuring symptom><decrease symptom><developmental><developmental disease><developmental disorder><digestive canal><digestive tract microbiome><disease causation><dorsal root ganglion><dysbacteriosis><dysbiosis><dysbiotic><dysmotility><dysmotility syndrome><electrophysiological><enteric microbiome><environmental risk><fewer symptoms><gastrointestinal><gastrointestinal function><gastrointestinal microbiome><gastrointestinal system><gene defect><genome mutation><glia signaling><glial signaling><gut dysbiosis><gut microbiome><gut-associated microbiome><heavy metal Pb><heavy metal lead><improved><in vivo><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><intestinal biome><intestinal microbiome><kids><mechanic><mechanical><mechanical force><microbial><microbial imbalance><microbiome adaptation><microbiome alteration><microbiome perturbation><model of autism spectrum disorder><motility disorder><mouse genetics><mouse model><murine model><mutant allele><nerve signaling><neural circuit><neural circuitry><neural dysfunction><neural signaling><neurocircuitry><neurodevelopmental disease><neuronal><neuronal signaling><neurotransmission><novel><pain behavior><pain signal><pathophysiology><pathway><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><perceptual stimulus><physicochemical phenomena related to the senses><reduce symptoms><relieves symptoms><repetitive behavior><response><sensory stimulus><social><social anxiety><social communication><social defects><social deficits><social disorders><social dysfunction><social role><socially anxious><sociobehavior><sociobehavioral><stereotypy><stressor><symptom alleviation><symptom association><symptom comorbidity><symptom reduction><symptom relief><synaptic circuit><synaptic circuitry><tactile sensation><treatment strategy><youngster>

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LEONARD K KACZMAREK

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 52/100

Likely hiring

Solid budget

Active award

$387,628

FY 2026

Project Title

Cellular Regulation of Sodium-activated Potassium Channels

Grant Number:

5R01NS102239-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2018

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT The KCNT1 gene encodes a Na+-activated K+ channel (KNa channel) termed Slack. These channels are bound directly to regulators of mRNA translation in neurons. Mutations in KCNT1 give rise to several childhood epilepsies as well as autism. These gain-of-function mutations produce a 3-20-fold ...

Research Terms

<3' Untranslated Regions><3'UTR><ASD><Action Potentials><Animal Model><Animal Models and Related Studies><Animals><Antisense Agent><Antisense Oligonucleotides><Assay><Autism><Autistic Disorder><Binding><Bioassay><Biological Assay><C-terminal><Cell Line><Cell membrane><CellLine><Cellular Regulation><Cerebral cortex><Characteristics><Closure by Ligation><Connector Neuron><Coupled><Cytoplasm><Cytoplasmic Membrane><DNA mutation><Development><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Ensure><Epilepsy><Epileptic Seizures><Epileptics><FMR-1 Protein><FMR1 Protein><FMR1 gene><FMRP><FMRP protein><FRAXA><Focal Seizure><Fragile X Mental Retardation 1 Gene><Fragile X Mental Retardation Protein><Genes><Genetic Change><Genetic defect><Genetic mutation><Glutamates><Goals><Immune Precipitation><Immunoprecipitation><In Situ Hybridization><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Ion Channel><Ionic Channels><Ions><Isoforms><K channel><Kanner's Syndrome><L-Glutamate><Ligation><Location><Membrane Channels><Messenger RNA><Mice><Mice Mammals><Molecular Interaction><Murine><Mus><Mutant Strains Mice><Mutation><NAV1.6><Na element><Na(v)1.1><NaCh6><Nav1.1><Nav1.2><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Non-Polyadenylated RNA><Pattern><Peptides><Physiologic><Physiological><Plasma Membrane><Potassium Channel><Potassium Ion Channels><Process><Property><Protein Biosynthesis><Protein Isoforms><Proteins><Pyramidal neuron><RNA><RNA Gene Products><RNA Splicing><Reporter><Ribonucleic Acid><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><SCN1A protein><SCN2A protein><SCN8A><SCN8A gene><Seizure Disorder><Seizures><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Sodium><Splicing><Strains Cell Lines><Syndrome><Testing><Therapeutic><Time><Translations><Upregulation><antisense oligo><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><beta Actin><cell cortex><cell growth regulation><cell type><childhood epilepsy><cultured cell line><developmental><differential expression><differentially expressed><disease causing variant><disease-causing allele><disease-causing mutation><early onset><electrophysiological><epilepsia><epileptogenic><excitatory neuron><experiment><experimental research><experimental study><experiments><fragile X FMR1 protein><fragile X mental retardation 1><fragile X mental retardation-1 protein><gain of function><gain of function mutation><genome mutation><glutamatergic><hippocampal pyramidal neuron><in situ Hybridization Genetics><in situ Hybridization Staining Method><infancy><infantile><inhibitor><inhibitory neuron><mRNA><mRNA Translation><migration><model of animal><mouse model><mouse mutant><murine model><mutant><na(v)1.2><neuronal><neuronal excitability><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><partial seizure><pathogenic allele><pathogenic variant><pediatric epilepsy><plasmalemma><protein synthesis><response><severe intellectual disability><sodium channel, voltage gated, type VIII, alpha subunit><transcriptional differences><translation><voltage><β-Actin>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Malavika Murugan

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$377,953

FY 2026

Project Title

Prefrontal circuits in processing social versus non-social rewards

Grant Number:

5R01MH130755-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/3/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Most mammals, including humans, navigate a life motivated and shaped by a drive to seek rewards such as food, water, and social interactions. Social stimuli can act as positive reinforcers, driving animals to pursue and interact with other members of their own species (e.g., people r...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

KATHRYN M ROEDER

CARNEGIE-MELLON UNIVERSITY, PITTSBURGH, PA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$377,691

FY 2026

Project Title

3/4 The Autism Sequencing Consortium: Discovering autism risk genes and how they impact core features of the disorder

Grant Number:

5R01MH129725-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract The past decade has seen outstanding advances in the genetics of autism spectrum disorder (ASD). Most of this progress has occurred by the study of rare genetic variation, especially de novo variation, with the Autism Sequencing Consortium (ASC) playing a central role. The A...

Research Terms

<1st trimester><21+ years old><ANK2><ANK2 gene><ASD><Acceleration><Adult><Adult Human><Affect><Ankyrin 2><Ankyrin-B><Autism><Autistic Disorder><Brain Ankyrin><Brain Diseases><Brain Disorders><Cell Communication and Signaling><Cell Signaling><Clinical><Copy Number Polymorphism><DNA mutation><Data><Development><Diagnosis><Disease><Disorder><Early Infantile Autism><Early Placental Phase><Encephalon Diseases><Family><First Pregnancy Trimester><First Trimester><Foundations><General Population><General Public><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Risk><Genetic Variation><Genetic defect><Genetic mutation><Goals><Hereditary><Heterogeneity><Individual><Infantile Autism><Inherited><International><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><Learning><Link><Mental disorders><Mental health disorders><Methods><Missense Mutation><Mission><Mutation><NIH><National Institutes of Health><Neurodevelopmental Disorder><Neurological Development Disorder><Neuronal Ankyrin><Nonerythroid Ankyrin><Nucleotides><Outcome><Pathogenesis><Pathway interactions><Pattern><Play><Population><Prevention><Process><Psychiatric Disease><Psychiatric Disorder><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><RFX3><Recommendation><Research><Research Grants><Research Project Grants><Research Projects><Research Resources><Resources><Risk><Risk-associated variant><Role><SEQ-AN><Sampling><Sequence Analyses><Sequence Analysis><Signal Transduction><Signal Transduction Systems><Signaling><Site><Source><Statistical Methods><Symptoms><TOPMed><Trans-Omics for Precision Medicine><Transmission><United States National Institutes of Health><Variant><Variation><adulthood><analytical method><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><biological signal transduction><cell type><cohort><copy number variant><copy number variation><developmental><developmental disease><developmental disorder><discover genes><disease risk><disorder risk><entire genome><exome><full genome><functional genomics><gain of function><gene discovery><genetic architecture><genome mutation><genomic data><genomic dataset><improved><indel><innovate><innovation><innovative><insertion/deletion><insertion/deletion mutation><insight><loss of function><low-frequency mutation><mental illness><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><neurodevelopmental disease><neuropsychiatric disease><neuropsychiatric disorder><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathway><population based><psychiatric illness><psychological disorder><rare allele><rare mutation><rare variant><repetitive behavior><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sex><social defects><social deficits><social disorders><social dysfunction><social role><statistic methods><therapeutic target><transmission process><whole genome>

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Seonil Kim

COLORADO STATE UNIVERSITY, FORT COLLINS, CO

Good lead · 52/100

Likely hiring

Solid budget

Active award

$359,780

FY 2026

Project Title

The roles of delta-catenin in social behavior

Grant Number:

5R01MH132921-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/15/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Many species depend on social activity to thrive, and social impairment is a fundamental symptom of several mental diseases. According to research, synaptic signals and activity can control social behavior. Yet, it is still unclear how synapse control and social behavior are related. δ-catenin funct...

Research Terms

<21+ years old><AMPA Receptors><ASD><Acute><Address><Adult><Adult Human><Affect><Aminoacetic Acid><Ammon Horn><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Animals><Assay><Autism><Autistic Disorder><Bioassay><Biological Assay><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Connector Neuron><Cornu Ammonis><Cyclicity><DNA mutation><Data><Disease><Disorder><Early Infantile Autism><Ensure><Etiology><Excitatory Synapse><Family><GSK-3beta><GSK-3β><Genes><Genetic Change><Genetic defect><Genetic mutation><Glutamates><Glycine><Glycogen Synthase Kinases><Hippocampus><Human><Impairment><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><KO mice><Kanner's Syndrome><Knock-out><Knock-out Mice><Knockout><Knockout Mice><L-Glutamate><L-Serine><Link><Location><Medial><Mediating><Mental disorders><Mental health disorders><Mice><Mice Mammals><Missense Mutation><Modern Man><Murine><Mus><Mutant Strains Mice><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Null Mouse><Parvalbumins><Pathway interactions><Patients><Pattern><Periodicity><Persons><Prefrontal Cortex><Psyche structure><Psychiatric Disease><Psychiatric Disorder><Pyramidal neuron><Reciprocal Social Interaction><Regulation><Research><Rhythmicity><Role><Serine><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Social Behavior><Social Change><Social Controls><Social Interaction><Social modification><Social transformation><Symptoms><Synapses><Synaptic><Testing><Thalamic structure><Thalamus><Viral><Wild Type Mouse><Work><adulthood><amygdaloid nuclear complex><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior test><behavioral test><biological signal transduction><causation><delta-catenin><disease causation><excitatory neuron><genome mutation><glutamatergic><glycogen synthase kinase 3 beta><glycogen synthase kinase 3β><hippocampal><hippocampal pyramidal neuron><knock-down><knockdown><mental><mental illness><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><mouse model><mouse mutant><murine model><mutant><neural><neuronal><optogenetics><patch clamp><pathway><postsynaptic><psychiatric illness><psychological disorder><shRNA><short hairpin RNA><social><social defects><social deficits><social disorders><social dysfunction><social role><sociobehavior><sociobehavioral><synapse><synapse function><synaptic function><thalamic><wildtype mouse><δ-catenin>

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Timothy J. Buschman

PRINCETON UNIVERSITY, Princeton, NJ

Good lead · 52/100

Likely hiring

Solid budget

Active award

$328,154

FY 2026

Project Title

Understanding the Neural Mechanisms Controlling Brain-wide Dynamics

Grant Number:

5R01MH126022-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Behavior emerges from the flow of information between brain regions. For example, finding a friend in a crowd requires the interaction of brain regions performing sensory processing, memory processing, and motor responses. Disrupting how neural activity flows through the bra...

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Luigi Puglielli

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 52/100

Likely hiring

Solid budget

Active award

$300,344

FY 2026

Project Title

ATase1 and ATase2, proteostasis, and neurological diseases

Grant Number:

5R01GM148487-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

We discovered that Nε-lysine acetylation occurs in the lumen of the endoplasmic reticulum (ER) in 2007. From that initial finding, we went on to discover the entire ER acetylation machinery (one membrane transporter, AT-1/SLC33A1, and two acetyltranferases, ATase1 and ATase2) and uncover a novel pie...

Research Terms

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EARL K MILLER

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, MA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$286,798

FY 2026

Project Title

Layer-specific manipulation to test feedforward/feedback cortical circuitry

Grant Number:

5R01MH131715-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

The cortex must filter out the bulk of sensory inputs. Not enough or too much filtering may underlie a variety of disorders like autism and schizophrenia. Mounting evidence suggests that this depends on alpha/beta (~8-30 Hz) oscillations vs gamma (>35 Hz) with associated spiking. They are ubiquitous...

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Richard L Huganir

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 48/100

Above-average budget

Very recent

Active award

$627,243

FY 2026

Project Title

The Dynamic AMPA Receptor Interactome During Plasticity and Learning

Grant Number:

4R37NS036715-27

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/1997

End Date:

2/28/2029

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary AMPA receptors (AMPARs) are the major excitatory neurotransmitter receptors in the brain and their dynamic trafficking is essential for synaptic plasticity that underlies memory. AMPARs participate in vast postsynaptic protein complexes that impact their properties and trafficking. We hypoth...

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Lisa M Hamrick

UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA, COLUMBIA, SC

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$216,612

FY 2026

Project Title

Vocal Development and Social Communication Outcomes of Children with an Older Sibling with Autism

Grant Number:

1K23DC022980-01A1

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/6/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Early language skills are predictive of later social, cognitive, and interpersonal development and are often disrupted in the younger siblings of autistic children, who are at elevated likelihood for social communication impairments. Evidence suggests that discrete features ...

Research Terms

<0-11 years old><3 year old><3 years of age><ASD><Age Months><Autism><Autistic Disorder><Behavior><Behavioral><Behavioral Research><Child><Child Youth><Childhood><Children (0-21)><Classification><Clinical><Cognitive><Communication Disorders><Communication impairment><Communicative Disorders><Data><Development><Diagnosis><Diagnostic><Disease><Disorder><Early Diagnosis><Early Infantile Autism><Early Intervention><Early identification><Faculty><Generalized Growth><Goals><Growth><Hour><Infant><Infantile Autism><Intervention><Kanner's Syndrome><Knowledge><Language><Language Delays><Language Development><Life><Link><Maps><Measures><Mentors><Methods><Mission><Modeling><NIDCD><National Institute on Deafness and Other Communication Disorders><Nursery Schools><Outcome><Population><Process><Research><Sampling><Siblings><Speech><Speech Therapy><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><System><Systematics><Therapy Evaluation><Time><Tissue Growth><Training><Translational Research><Translational Science><Translations><Work><acquiring language skills><age 3><age 3 years><analyzing longitudinal><autism spectral disorder><autism spectrum disorder><autistic><autistic children><autistic spectrum disorder><career><career development><child health care provider><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical translation><clinically translatable><developmental><early childhood><early detection><functional outcomes><improved><infancy><infantile><insight><kids><language ability><language acquisition><language learning><language skills><longitudinal analysis><ontogeny><pediatric><pediatric care provider><pediatric health care provider><pediatric provider><pediatrician><pre-k><pre-kindergarten><preschool><programs><skills><social><social communication><social communication impairment><statistical analysis><tenure process><tenure track><three year old><three years of age><translation><translation research><translational investigation><translational opportunities><translational potential><vocalization><youngster>

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Emily J Knight

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$192,672

FY 2026

Project Title

Translational Virtual Reality and Electrophysiologic Investigation of Audiovisual Spatial Attention in ASD and ADHD

Grant Number:

1K23DC022971-01A1

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2030

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT Children with autism spectrum disorder (ASD) and attention deficit hyperactivity disorder (ADHD) often struggle to understand speech in noisy environments, impairing community participation. Despite the high prevalence of these auditory processing disorders, evidence-based interventions re...

Research Terms

<0-11 years old><12 year old><12 years of age><AD/HD><ADHD><ASD><Acoustic Perceptual Disorder><Address><Attention><Attention deficit hyperactivity disorder><Attentional deficit><Auditory><Auditory Comprehension Disorder><Auditory Perceptual Diseases><Auditory Perceptual Disorders><Auditory Processing Disorder><Autism><Autistic Disorder><Automobile Driving><Behavioral><Brain><Brain Nervous System><Child><Child Youth><Children (0-21)><Clinical><Clinical Trials Design><Cognitive><Community Participation><Data><Detection><Development><Diagnosis><Diagnostic><Dimensions><Diminished Vision><Dysfunction><Early Infantile Autism><Education for Intervention><Educational Intervention><Electrophysiology><Electrophysiology (science)><Encephalon><Ensure><Environment><Evidence based intervention><Family><Feedback><Focus Groups><Fostering><Functional disorder><Future><Heterogeneity><High Prevalence><Home><Human><Impairment><Infantile Autism><Instruction Intervention><Intervention><Intervention Strategies><Investigation><Kanner's Syndrome><Language><Learning Disorders><Link><Lip><Lip structure><Low Vision><Measures><Medical center><Mentorship><Modern Man><Movement><Neurodevelopmental Disorder><Neurological Development Disorder><Neurophysiology / Electrophysiology><Neuropsychologic Tests><Neuropsychological Tests><Neuropsychologies><Neuropsychology><Neurosciences><Outcome><Parents><Partial Sight><Participant><Pattern><Pediatrics><Perception><Phenotype><Physiopathology><Position><Positioning Attribute><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Prevalence><Process><Psychoacoustical Disorders><Public Health><Qualitative Research><Randomized, Controlled Trials><Reduced Vision><Research><Research Design><Role><Sampling><School-Age Population><Sensory><Series><Specificity><Speech><Speech Perception><Speech Sound><Stimulus><Study Type><Subgroup><Subnormal Vision><Symptoms><Technology><Testing><Time><Training><Training Intervention><Translating><Translations><Treatment Efficacy><Universities><Visual><Visual Evoked Potentials><Visual Evoked Response><Visual evoked cortical potential><Visual impairment><Visuospatial><Work><age 12><age 12 years><attentive deficit><audiovisual speech><auditory processing><auditory-visual speech><autism spectral disorder><autism spectrum disorder><autistic children><autistic spectrum disorder><body movement><brain behavior><central processing disorder><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical applicability><clinical application><clinical heterogeneity><clinical phenotype><co-morbid><co-morbidity><cohort><community engaged participatory research><community engaged research><community partnered research><community-engaged study><community-partnered study><comorbidity><design><designing><developmental><driving><electrophysiological><evidence base><feasibility testing><hearing in noise><homes><improved><indexing><instructional intervention><intervention design><intervention efficacy><investigator training><kids><language ability><language skills><neural><neural mechanism><neurodevelopmental disease><neuromechanism><neurophysiological><neurophysiology><neuropsychologic><noise perception><novel><parent><pathophysiology><pediatric department><programs><prototype><randomized control trial><school age><skills><social><social role><speech in background noise><speech in noise><speech in speech recognition><speech recognition in noise><stakeholder insights><stakeholder perspectives><study design><sustained attention><therapeutic efficacy><therapy design><therapy efficacy><translation><treatment design><twelve year old><twelve years of age><user centered design><virtual reality><virtual reality intervention><virtual reality-based intervention><vision impairment><visual spatial><visually impaired><youngster>

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Victor G. Corces

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 48/100

Likely hiring

Recent

Active award

$98,487

FY 2026

Project Title

Gene-Environment interactions in Autism

Grant Number:

5R01ES033603-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/20/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT Autism spectrum disorder (ASD) is group of neurodevelopmental conditions characterized by impaired social interactions, repetitive or restrictive behaviors, and difficulties with communication. ASD is highly prevalent, affecting 1 in 54 children in the US. Whole genome and exome sequencing ...

Research Terms

<0-11 years old><ASD><ASD patient><ATAC sequencing><ATAC-seq><ATACseq><Affect><Age><Air><Alleles><Allelomorphs><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Autopsy><Bar Codes><Basal Transcription Factor><Basal transcription factor genes><Behavior><Behavioral><Binding><Bioassay><Biological Assay><Blood><Blood Reticuloendothelial System><Brain><Brain Nervous System><Brain region><Breast Cancer><Cardiac Diseases><Cardiac Disorders><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Line><Cell Lineage><CellLine><Cells><Cerebral cortex><Cerebrovascular system><Cerebrum><Chemicals><Child><Child Youth><Children (0-21)><Chromatin><Chronic Disease><Chronic Illness><Code><Coding System><Collection><Communication><Cosmetics><DNA mutation><Dendritic Spines><Dependence><Developing fetus><Development><Diagnosis><Disease><Disorder><Early Infantile Autism><Encephalon><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine disrupting agent><Environment><Exposure to><Family><Female><Fetal Development><Food><Functional RNA><GWA study><GWAS><Gene Expression><Gene x Environment Interaction><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Genetic Change><Genetic defect><Genetic mutation><Genome><Germ Lines><Glia><Glial Cells><Goals><Growth><GxE interaction><Heart Diseases><Household Products><Household Supplies><Human><Hydrogen Oxide><Impairment><Incidence><Individual><Infantile Autism><Kanner's Syndrome><Knowledge><Kolliker's reticulum><Laboratory Animals><Malignant Breast Neoplasm><Malignant Testicular Neoplasm><Malignant Testicular Tumor><Malignant Tumor of the Testis><Malignant neoplasm of testis><Mice><Mice Mammals><Modern Man><Molecular Interaction><Monitor><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurological Development Disorder><Neurons><Non-neuronal cell><Noncoding RNA><Nonneuronal cell><Nontranslated RNA><Nuclear Hormone Receptor Superfamily><Nuclear Hormone Receptors><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Obesity><Organoids><Paper><Pathway interactions><Patients><Penetrance><Phenotype><Plastics><Population><Process><Race><Races><Regulatory Regions><Reporter><Research><Risk><Role><Sampling><Single-Nucleus Sequencing><Site><Social Interaction><Societies><Strains Cell Lines><Testicular Cancer><Testing><Testis Cancer><Time><Tissue Growth><Transcription Factor Proto-Oncogene><Transcription factor genes><Untranslated RNA><Urine><Variant><Variation><Water><adiposity><ages><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic children><autistic features><autistic patient><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><barcode><base><bases><bisphenol A><blood vessels in the brain><brain blood vessels><brain tissue><brain vasculature><building materials><cell type><cellular differentiation><cerebral><cerebral blood vessel><cerebral vasculature><cerebrovascular vessels><cerebrovasculature><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><chronic disorder><combinatorial><corpulence><cosmetic product><cultured cell line><dendrite spine><density><developmental><diphenylolpropane><endocrine disrupting compound><entire genome><environment effect on gene><environmental chemical><exome sequencing><exome-seq><experiment><experimental research><experimental study><experiments><exposed human population><full genome><gene environment interaction><genetic regulatory element><genome editing><genome mutation><genome scale><genome sequencing><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic editing><gray matter><heart disorder><hiPSC><human exposure><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSCs><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><kids><malignant breast tumor><necropsy><nerve cement><nerve stem cell><neural><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopmental disease><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><noncoding><novel><ontogeny><pathway><patient with ASD><postmortem><pregnant><progenitor and neural stem cells><programs><protein function><racial><racial background><racial origin><response><sNuc-Seq><sex><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social communication><social integration><social role><substantia alba><substantia grisea><transcription factor><white matter><whole genome><whole genome association analysis><whole genome association study><youngster><♀>

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David M. James

UNIVERSITY OF OREGON, EUGENE, OR

Good lead · 48/100

Training-friendly

Very recent

Active award

$81,580

FY 2026

Project Title

Microbiome Modulation of Visual System Development

Grant Number:

5F32EY035578-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Visual system dysfunction is a common and debilitating comorbidity for individuals diagnosed with a variety of neurodevelopmental disorders (NDDs), including autism spectrum disorder (ASD), schizophrenia, and attention deficit hyperactivity disorder. The microbiome is emerging as an ...

Research Terms

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ERIN MARIE ANDRES

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Good lead · 48/100

Training-friendly

Very recent

Active award

$79,348

FY 2026

Project Title

Caregiver Cry Perception and Developmental Trajectories of Infant-Caregiver Interactions Involving Cry as an Early Marker of Autism

Grant Number:

5F32MH134481-03

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Caregivers of children with autism spectrum disorders often recall differences in their children as early as infancy, despite most children with autism being diagnosed after age 3. Caregiver recall of behavioral differences in infancy indicates that there is more to learn from the ea...

Research Terms

<0-11 years old><1 year of age><1 year old><21+ years old><3 year old><3 years of age><ASD><Acoustics><Address><Adult><Adult Human><Age Months><Area><Autism><Autism Diagnosis><Autistic Disorder><Automobile Driving><Behavioral><Brain><Brain Nervous System><Care Givers><Caregivers><Characteristics><Child><Child Youth><Children (0-21)><Clinical><Collection><Communication><Crying><Data><Data Analyses><Data Analysis><Development><Diagnosis><Dimensions><Discipline><Early Infantile Autism><Early Intervention><Encephalon><Female><Foundations><Frequencies><Functional MRI><Functional Magnetic Resonance Imaging><Goals><Grant><Heterogeneity><Human><Impairment><Infant><Infantile Autism><Interdisciplinary Research><Interdisciplinary Study><Intervention><Investigators><Kanner's Syndrome><Knowledge><Language Delays><Language Development><Lead><Learning><Libraries><Life><Long-term prospective studies><Measurement><Measures><Mediating><Mentors><Modeling><Modern Man><Multidisciplinary Collaboration><Multidisciplinary Research><Outcome><Pain><Painful><Parents><Pattern><Pb element><Perception><Phenotype><Play><Population><Process><Prospective Studies><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Support><Research Training><Researchers><Risk><Risk Marker><Role><Sampling><Social Interaction><Source><Special Population><Speech><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Structure><Testing><Time><Training><Writing><acquiring language skills><adulthood><age 1><age 1 year><age 3><age 3 years><aged 1 year><aged one year><analyzing longitudinal><autism attributes><autism biomarker><autism indicator><autism marker><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic><autistic children><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><career><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><data interpretation><developmental><developmental disease><developmental disorder><driving><dyadic interaction><early screening><experience><fMRI><heavy metal Pb><heavy metal lead><high risk><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><infancy><infantile><kids><language ability><language acquisition><language learning><language outcome><language skills><longitudinal analysis><longitudinal, prospective study><male><neurobehavioral><one year of age><one year old><parent><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><prospective research study><prospective survey><response><risk predictor><risk predictors><skills><social><social communication><social role><statistical analysis><three year old><three years of age><trend><verbal><vocalization><youngster><♀><♂>

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Emily Krueger

CASE WESTERN RESERVE UNIVERSITY, CLEVELAND, OH

Good lead · 48/100

Training-friendly

Very recent

Active award

$54,538

FY 2026

Project Title

Investigating the Structural Basis of Human Glycine Receptor Modulation for Neurodevelopmental Disorders

Grant Number:

5F30HD114399-03

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/29/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Mutations in glycine receptor alpha 2 (GlyRα2), an anionic-selective pentameric ligand-gated ion channel, have been implicated in neurodevelopmental disorders such as autism spectrum disorder and epilepsy. This receptor plays an important role in neurodevelopment and mediates tonic inhibiti...

Research Terms

<21+ years old><ASD><Address><Adult><Adult Human><Affect><Agonist><Aminoacetic Acid><Anions><Aquadiol><Area><Autism><Autistic Disorder><Binding><Brain><Brain Nervous System><Cell Membrane Lipids><Corpus Luteum Hormone><Coupling><Cryo-electron Microscopy><Cryoelectron Microscopy><DNA mutation><Data><Delta4-pregnene-3,20-dione><Development><Dimenformon><Diogyn><Diogynets><Disease><Disorder><Drug Therapy><Early Infantile Autism><Electron Cryomicroscopy><Electrophysiology><Electrophysiology (science)><Encephalon><Environment><Epilepsy><Epileptic Seizures><Epileptics><Estrace><Estradiol><Estradiol-17 beta><Estradiol-17beta><Estraldine><External Domain><Extracellular Domain><Family><Fore-Brain><Forebrain><Future><Genetic Change><Genetic defect><Genetic mutation><Glycine><Glycine Receptors><Goals><Health><Human><Impairment><Infantile Autism><Investigation><Ion Channel><Ion Channel Gating><Ion Channel Gatings><Ionic Channels><Kanner's Syndrome><Kinetics><Knowledge><Length><Ligand Binding><Ligands><Link><Lipids><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Membrane><Membrane Channels><Membrane Lipids><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Modern Man><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Movement><Mutation><Neonatal><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neural Development><Neural Transmission><Neurocyte><Neurodevelopmental Disorder><Neurologic Body System><Neurologic Organ System><Neurological Development Disorder><Neurons><Neurophysiology / Electrophysiology><Ovocyclin><Ovocylin><Pathology><Pharmacological Treatment><Pharmacotherapy><Physiologic><Physiological><Physiology><Play><Pregn-4-ene-3,20-dione><Pregnenedione><Process><Progesterone><Progynon><Property><Prosencephalon><Proteins><Rationalization><Receptor Protein><Resolution><Role><Seizure Disorder><Site><Site-Directed Mutagenesis><Site-Specific Mutagenesis><Specificity><Structure><Structure-Activity Relationship><Surface Proteins><Synapses><Synaptic><Synaptic Transmission><TM Domain><Targeted DNA Modification><Targeted Modification><Testing><Therapeutic><Therapeutic Estradiol><Therapeutic Progesterone><Time><Transmembrane Domain><Transmembrane Region><Work><adulthood><alleviate symptom><ameliorating symptom><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><body movement><chemical structure function><conformation><conformational><conformational state><conformationally><conformations><cryo-EM><cryoEM><cryogenic electron microscopy><decrease symptom><desensitization><developmental><differential expression><differentially expressed><drug intervention><drug treatment><electrophysiological><epilepsia><epileptogenic><fewer symptoms><genome mutation><improved><interest><locomotor learning><member><membrane structure><motor learning><nervous system development><neurodevelopment><neurodevelopmental disease><neurogenesis><neuronal><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><patch clamp><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><postsynaptic><receptor><receptor function><reduce symptoms><relieves symptoms><resolutions><response><social role><structure function relationship><symptom alleviation><symptom reduction><symptom relief><synapse><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcriptional differences>

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Rebecca Shear

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Good lead · 48/100

Training-friendly

Very recent

Active award

$43,714

FY 2026

Project Title

Mechanism of Par1c-mediated AMPA receptor trafficking and synaptic plasticity

Grant Number:

5F31NS143354-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract The human brain is remarkably unique in its high capacity to learn and adapt to new environments, which has been attributed to the plasticity of synaptic connections. One form of synaptic plasticity, long-term potentiation (LTP), is associated with AMPA receptor trafficking ...

Research Terms

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Phinea Z Romero

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 48/100

Training-friendly

Very recent

Active award

$38,224

FY 2026

Project Title

Kir2.1 channel dysfunction underlies neurovascular coupling impairment in autism

Grant Number:

1F31HL184931-01

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/30/2026

End Date:

3/29/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Autism spectrum disorder (ASD) affects an estimated 1 in 36 children (2.8%) in the US and is among the top 10 causes of child disability worldwide. Despite its significant medical and economic burden, current therapeutics are limited and none of the available medications treat the 3 ...

Research Terms

<0-11 years old><16p11.2><2-photon><ASD><Action Potentials><Address><Affect><Agonist><Autism><Autistic Disorder><Bioavailability><Biological Availability><Blinded><Blood Vessels><Blood capillaries><Blood flow><Brain><Brain Nervous System><Brain Vascular><Capillary Endothelial Cell><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cephalic><Cerebrovascular Circulation><Cerebrovascular system><Child><Child Youth><Children (0-21)><Communication><Cranial><Data><Diameter><Drugs><Dysfunction><Early Infantile Autism><Economic Burden><Electrophysiology><Electrophysiology (science)><Encephalon><Endothelial Cells><Endothelium><Exhibits><Foundations><Functional disorder><Functional impairment><Genes><Goals><Health><Heart Vascular><Hyperemia><Image><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><In Vitro><Incidence><Infantile Autism><Inositide Phospholipids><Inositol Phosphoglycerides><Inositol Phospholipids><Intracellular Communication and Signaling><Investigation><Kanner's Syndrome><Kir2.1 channel><Leiomyocyte><Link><Measures><Mediating><Medical><Medication><Metabolic><Mice><Mice Mammals><Molecular><Murine><Mus><Myography><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Neurophysiology / Electrophysiology><Neurosciences><Nutrient><O element><O2 element><Oxygen><P2Y(2) receptor><P2Y2 receptor><PIP2><Pathology><Pathway interactions><Pharmaceutical Preparations><Pharmacology><Phosphatidyl Inositol><Phosphatidylinositol 4,5-Biphosphate><Phosphatidylinositol 4,5-Diphosphate><Phosphatidylinositol-4,5-Bisphosphate><Phosphatidylinositols><Phosphoinositides><Physiologic Availability><Physiopathology><Play><Prevalence><Process><Production><PtIns 4,5-P2><PtdIns><PtdInsP2><Publishing><Purine Receptors><Purinergic Receptors><Purinoceptor><Ramp><Research><Risk><Role><Seminal><Signal Transduction><Signal Transduction Systems><Signaling><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Source><Specific qualifier value><Specificity><Specified><Staining method><Stains><Testing><Therapeutic><Time><Training><Trees><Work><adult youth><antagonism><antagonist><arteriole><autism attributes><autism indicator><autism model><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><behavior phenotype><behavioral phenotyping><biological signal transduction><blood flow in brain><blood vessels in the brain><brain blood circulation><brain blood flow><brain blood vessels><brain capillary><brain vasculature><capillary><cardiovascular disorder><cell type><cerebral blood flow><cerebral blood vessel><cerebral capillary><cerebral circulation><cerebral vascular><cerebral vasculature><cerebro-vascular><cerebrocirculation><cerebrovascular><cerebrovascular blood flow><cerebrovascular vessels><cerebrovasculature><circulatory system><cofactor><cognitive function><disability><drug/agent><effective therapy><effective treatment><electrophysiological><endothelial dysfunction><experiment><experimental research><experimental study><experiments><extracellular><imaging><in vivo><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><insight><interpersonal competence><interpersonal competency><kcnj2 channel><kids><lens><lenses><model of autism spectrum disorder><mouse model><murine model><neuro-vascular coupling><neurodevelopmental disease><neuronal><neurovascular coupling><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><parenchymal arterioles><patch clamp><pathophysiology><pathway><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><pharmacologic><pressure><repetitive behavior><response><social competence><social competency><social role><social skills><synergism><two-photon><vascular><vascular contributions><voltage><young adult><young adult age><young adulthood><youngster>

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William Quackenbush

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 48/100

Training-friendly

Very recent

Active award

$34,980

FY 2026

Project Title

The Neurodiversity of Motor Stereotypies: Elucidating Common Brain-Behavior Relationships Across Sensory Landscapes

Grant Number:

1F31MH142089-01

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary We live in an ever-constant Ʋuctuation of sensory input, and navigating this can be easily overwhelming. To remedy this, our brains have devised sensory sampling behaviors to rhythmically parse out this input and optimize sensory processing by weighting sensory experiences time-locke...

Research Terms

<0-11 years old><ASD><Adolescent><Adolescent Youth><Augmented Reality><Autism><Autistic Disorder><Behavior><Behavioral><Brain><Brain Nervous System><Brain region><Child><Child Development><Child Youth><Children (0-21)><Classification><Communication><Complex><Coping Behavior><Coupling><Cyclicity><Data><Data Bases><Databases><Delta Rhythm><Development><Diagnosis><Diagnostic><EEG><Early Infantile Autism><Electroencephalogram><Electroencephalography><Encephalon><Environment><Esthesia><Event><Foundations><Frequencies><Future><Goals><Hand><High Frequency Oscillation><Hypersensitivity><Individual><Infant and Child Development><Infantile Autism><Investigators><Kanner's Syndrome><Leg><Modeling><Motion><Motor><Motor Cortex><Movement><Participant><Patient Self-Report><Perception><Periodicity><Persons><Phase><Population><Primates><Primates Mammals><Process><Regulation><Reporting><Research Personnel><Researchers><Rhythmicity><Rodent><Rodentia><Rodents Mammals><Role><Saccades><Saccadic Eye Movements><Saccadic Pursuit><Sampling><Self-Report><Sensation><Sensory><Stereotyped Behavior><Stereotyping><Systematics><Time><Video Recording><Videorecording><autism spectral disorder><autism spectrum disorder><autistic><autistic spectrum disorder><body movement><brain behavior><coping mechanism><data base><data base structure><database structure><design><designing><developmental><experience><hands><improved><juvenile><juvenile human><kids><kinematic model><kinematics><neural><neural mechanism><neuromechanism><neurophysiological><neurophysiology><novel><open source><perceptual stimulus><physicochemical phenomena related to the senses><response><sensory cortex><sensory input><sensory mechanism><sensory stimulus><social role><social stigma><stereotypy><stigma><video recording system><youngster>

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Jessica M Schwartzman

CHILDREN'S HOSPITAL OF LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$161,122

FY 2026

Project Title

Reward responsivity and depression in autism spectrum disorder: A multimethod approach

Grant Number:

5K23MH131852-04

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Adolescents with Autism Spectrum Disorder experience depression at rates nearly twice that of their neurotypical peers (20% vs. 11%). Untreated depression is associated with adverse short (e.g., school refusal) and long-term outcomes (e.g., poor physical health, lower employment) tha...

Research Terms

<12-20 years old><17 year old><17 years of age><21+ years old><ASD><Active Follow-up><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Affective Disorders><Autism><Autistic Disorder><Behavioral><Biological Markers><Clinical><Communication challenge><Communication difficulty><Complex><Development><Development Plans><Developmental Course><Diagnostic><EEG><Early Diagnosis><Early Infantile Autism><Early Intervention><Electroencephalogram><Electroencephalography><Emotional Depression><Employment><Event-Related Potentials><Face><Family member><Future><Goals><High Prevalence><Impairment><Infantile Autism><Intervention><Interview><Investigation><K23 Award><K23 Mechanism><K23 Program><Kanner's Syndrome><Knowledge><Literature><Maintenance><Measurement><Measures><Mental Depression><Mental disorders><Mental health disorders><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentors><Mentorship><Methodology><Methods><Modeling><Mood Disorders><NIMH><National Institute of Mental Health><Neurobiology><Outcome><Pathway interactions><Physiologic Psychology><Physiological Psychology><Population><Positive Valence><Prevalence><Provider><Psychiatric Disease><Psychiatric Disorder><Psychophysiological><Psychophysiology><QOL><Quality of life><RDoC><Research><Research Domain Criteria><Rewards><Risk><Risk Factors><Sampling><Schedule><Schizophrenia><Schizophrenic Disorders><Schools><Severities><Social Interaction><Social Processes><Strategic Planning><Symptoms><Techniques><Testing><Time><Training><Translating><Translational Research><Translational Science><Vulnerable Populations><Work><active followup><adolescence (12-20)><adolescent depression><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><adolescents with depression><adulthood><age 17><age 17 years><analyzing longitudinal><autism spectral disorder><autism spectrum disorder><autistic adolescent><autistic spectrum disorder><autistic youth><bio-markers><biologic marker><biomarker><career><career development><child depression><childhood depression><childhood onset depression><clinical translation><clinically translatable><death risk><dementia praecox><depressed adolescents><depression><depression in adolescence><depression symptom><depressive><depressive symptoms><develop therapy><developmental><early detection><emotional experience><event related potential><experience><faces><facial><follow up><follow-up><followed up><followup><high risk><intervention development><investigate longitudinal><juvenile><juvenile human><longitudinal analysis><longitudinal design><longitudinal experimental design><longitudinal investigation><longitudinal research><longitudinal research design><longitudinal study design><mental illness><method development><mortality risk><neural><neurobiological><neurophysiological><neurophysiology><novel><pathway><pediatric depression><peer><physical conditioning><physical health><physiopsychology><premature><prematurity><prospective><psychiatric illness><psycho-physiological><psychological disorder><recruit><response><schizophrenic><screening><screenings><seventeen year old><seventeen years of age><social><social communication><study longitudinal><suicidal morbidity><suicide death><suicide morbidity><survey longitudinal><symptomatology><therapy development><translation research><translational investigation><treatment development><vulnerable group><vulnerable individual><vulnerable people><youth depression><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder>

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Megan Chaya Gross

UNIVERSITY OF MASSACHUSETTS AMHERST, HADLEY, MA

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$150,510

FY 2026

Project Title

Dual-Language Communication and Social-Cognitive Skills in Bilingual Children with ASD

Grant Number:

5K23DC020224-04

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Slightly over 1 in 5 children in the United States are growing up in a household that speaks a language other than English. For these children, developing bilingual skills will allow them to communicate both with family members who have limited English skills and with English-speaking teachers and p...

Research Terms

<0-11 years old><4 year old><4 years of age><AAC Device><AAC Intervention><ASD><Affect><Area><Augmentative and Alternative Communication><Autism><Autistic Disorder><Behavior><Care Givers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caregivers><Child><Child Development><Child Support><Child Youth><Children (0-21)><Clinical Treatment><Code><Coding System><Cognitive><Collaborations><Communication><Communication Disorders><Communication impairment><Communicative Disorders><Communities><Data><Development><Diagnosis><Early Infantile Autism><Environment><Espanol><Evaluation><Exclusion><Exposure to><Family><Family member><Frequencies><Future><Goals><Hearing><Home><Hour><Household><Human><Infant and Child Development><Infantile Autism><Intervention><Interview><K-Awards><K-Series Research Career Programs><Kanner's Syndrome><Language><Language Development><Language Therapy><Learning><Linguistic><Linguistics><Maintenance><Measures><Mentors><Methods><Modern Man><NIDCD><National Institute on Deafness and Other Communication Disorders><Parents><Phase><Population><Prevention><Professional Education><Provider><Psychology><Public Health><Questionnaires><Reporting><Research><Research Career Program><Role><Sampling><Schools><Services><Social Development><Source><Spanish><Speech><Strategic Planning><Structure><Thinking><Time><Training><United States><Variant><Variation><Voice><Work><acquiring language skills><age 4><age 4 years><autism spectral disorder><autism spectrum disorder><autistic children><autistic spectrum disorder><bilingual><bilingualism><career development><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical intervention><clinical therapy><cognitive development><cognitive process><cognitive skill><community based design><community based participatory research><community based research><community intervention><community led research><community level intervention><community participatory research><community partnered participatory research><community-based intervention><design><designing><developmental><executive control><executive function><experience><eye tracking><family support><flexibility><flexible><four year old><four years of age><homes><improved><improved outcome><kids><language ability><language acquisition><language learning><language processing><language skills><minimally speaking><minimally verbal><natural language><parent><participatory action research><peer><perspective taking><phrases><service providers><skills><social><social role><teacher><theory of mind><thoughts><trial regimen><trial treatment><understanding others' perspectives><verbal><visual tracking><youngster>

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JOSEPH D DOUGHERTY

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 40/100

Large award

Active award

$2,434,430

FY 2026

Project Title

Systematic and scalable phenotyping of mouse mutants for neuropsychiatric disease genetics

Grant Number:

5RM1MH138313-02

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT In the past decade, significant progress has been made in identifying genetic variants associated with neurodevelopmental and psychiatric disorders like autism, schizophrenia, and intellectual disability. However, understanding how these genes affect brain function and contr...

Research Terms

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Harrison W Gabel

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 40/100

Large award

Active award

$2,434,430

FY 2026

Project Title

Systematic and scalable phenotyping of mouse mutants for neuropsychiatric disease genetics

Grant Number:

5RM1MH138313-02

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT In the past decade, significant progress has been made in identifying genetic variants associated with neurodevelopmental and psychiatric disorders like autism, schizophrenia, and intellectual disability. However, understanding how these genes affect brain function and contr...

Research Terms

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Alexxai V Kravitz

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 40/100

Large award

Active award

$2,434,430

FY 2026

Project Title

Systematic and scalable phenotyping of mouse mutants for neuropsychiatric disease genetics

Grant Number:

5RM1MH138313-02

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT In the past decade, significant progress has been made in identifying genetic variants associated with neurodevelopmental and psychiatric disorders like autism, schizophrenia, and intellectual disability. However, understanding how these genes affect brain function and contr...

Research Terms

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Susan Eileen Maloney

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 40/100

Large award

Active award

$2,434,430

FY 2026

Project Title

Systematic and scalable phenotyping of mouse mutants for neuropsychiatric disease genetics

Grant Number:

5RM1MH138313-02

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT In the past decade, significant progress has been made in identifying genetic variants associated with neurodevelopmental and psychiatric disorders like autism, schizophrenia, and intellectual disability. However, understanding how these genes affect brain function and contr...

Research Terms

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Robi D Mitra

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 40/100

Large award

Active award

$2,434,430

FY 2026

Project Title

Systematic and scalable phenotyping of mouse mutants for neuropsychiatric disease genetics

Grant Number:

5RM1MH138313-02

Activity Code:

RM1

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT In the past decade, significant progress has been made in identifying genetic variants associated with neurodevelopmental and psychiatric disorders like autism, schizophrenia, and intellectual disability. However, understanding how these genes affect brain function and contr...

Research Terms

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Susan Faja

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Exploratory lead · 40/100

Above-average budget

Recent

Active award

$990,550

FY 2026

Project Title

Developing Cognitive Control and Metacognition to Reduce the Functional Impact of Restricted and Repetitive Behaviors in Autism

Grant Number:

1R61MH139596-01

Activity Code:

R61

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/10/2026

End Date:

2/29/2028

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY ABSTRACT Effective interventions to reduce the functional impact of core features of autism spectrum disorder (ASD) in school-aged children are critically needed. This R61/R33 application proposes to test whether in-person computer training delivered individually by a coach engages a...

Research Terms

<0-11 years old><8 year old><8 years of age><AD/HD><ADHD><ASD><Address><Anxiety><Arousal><Assay><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Behavior><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Bioassay><Biological Assay><Biological Markers><Care Givers><Caregivers><Cell Communication and Signaling><Cell Signaling><Child><Child Youth><Children (0-21)><Clinical><Clinical Trials><Cognitive><Cognitive Discrimination><Complex><Computers><Conditioning Therapy><Conflict><Conflict (Psychology)><Control Groups><Data><Development><Discrimination><EEG><Early Infantile Autism><Education><Educational aspects><Electroencephalogram><Electroencephalography><Event-Related Potentials><Evidence based intervention><Exhibits><Goals><Immediate Memory><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Intracellular Communication and Signaling><Kanner's Syndrome><Lead><Link><Literature><Measures><Mediating><Mediator><Monitor><NIMH><National Institute of Mental Health><Neurosciences><Outcome><Parents><Pathway interactions><Pattern><Pb element><Performance><Persons><Phase><Physiologic><Physiological><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Provider><RDoC><Randomized><Reporting><Research Domain Criteria><Sampling><School-Age Population><Services><Short-Term Memory><Signal Transduction><Signal Transduction Systems><Signaling><Solid><Subgroup><Symptoms><System><Testing><Thinking><Time><Training><Training Activity><Training Programs><Waiting Lists><Work><acceptability and feasibility><active control><active control group><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><age 8><age 8 years><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic><autistic adolescent><autistic children><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic youth><autistic-like symptoms><behavior intervention><behavior measurement><behavioral intervention><behavioral measure><behavioral measurement><bio-markers><biologic marker><biological signal transduction><biomarker><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical relevance><clinical significance><clinically relevant><clinically significant><cognitive control><cognitive neuroscience><cognitive training><comparator group><comparison group><cost effective><design><designing><developmental><effective intervention><eight year old><eight years of age><event related potential><flexibility><flexible><heavy metal Pb><heavy metal lead><innovate><innovation><innovative><insight><intellectual and developmental disability><interest><intervention delivery><intervention effect><kids><limited intellectual functioning><metacognition><neural><novel><parent><pathway><programs><psychopharmacologic><psychopharmacological><randomisation><randomization><randomly assigned><repetitive behavior><response><school age><secondary outcome><skill acquisition><skill development><skills><social><social stigma><stigma><teacher><theories><thoughts><tool><training module><trial design><waitlist><working memory><youngster><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder>

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Jessica M Schwartzman

CHILDREN'S HOSPITAL OF LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 40/100

Above-average budget

Recent

Active award

$769,500

FY 2026

Project Title

Feasibility, acceptability, and preliminary effectiveness of Cognitive Behavioral Therapy for Depression in Autistic Youth in clinical settings

Grant Number:

1R34MH140993-01

Activity Code:

R34

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

3/14/2029

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Autistic youth are far more likely to experience depression and suicidal thoughts and behaviors than their non- autistic peers, yet few autistic youth receive appropriate treatment. Untreated depression is associated with adverse short- (e.g., school refusal) and long-term o...

Research Terms

<11 year old><11 years of age><17 year old><17 years of age><ASD><Address><Affective><Alexithymias><Ambulatory Care Facilities><Anxiety><Application Context><Autism><Autistic Disorder><Behavioral><Caring><Children's Hospital><Clinic><Clinical><Clinical Trials><Cognition Therapy><Cognitive><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Data><Early Infantile Autism><Effectiveness><Emergency medical service><Emotional><Emotional Depression><Evidence based intervention><Evidence based treatment><Exclusion><Family><Feedback><Feeling suicidal><Future><Goals><Hybrids><Impairment><Individual><Infantile Autism><Intervention><Intervention Studies><Interview><Kanner's Syndrome><Life><Measurement><Mental Depression><Methods><Modeling><Needs Assessment><Obsessive-Compulsive Disorder><Obsessive-Compulsive Neurosis><Outcome><Outpatient Clinics><Parents><Pediatric Hospitals><Personal awareness><Phase><Population><Population Heterogeneity><Protocol><Protocols documentation><Public Health><QOL><Quality of life><Randomized, Controlled Trials><Recommendation><Research><Schools><Self Perception><Self image><Self view><Sensory><Services><Severities><Suicidal thoughts><Suicide><Survey Instrument><Surveys><Testing><Thinking><Training><Uncertainty><Youth><Youth 10-21><acceptability and feasibility><access disparities><accessibility disparities><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><adverse consequence><adverse outcome><age 11><age 11 years><age 17><age 17 years><autism spectral disorder><autism spectrum disorder><autistic><autistic adolescent><autistic individuals><autistic people><autistic spectrum disorder><autistic youth><barrier to care><barrier to health care><barrier to treatment><care as usual><clinical significance><clinically significant><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><community building><community engagement><community setting><contextual factors><cost><depression><depression symptom><depressive><depressive symptoms><disparities in access><diverse populations><doubt><effectiveness and implementation trial><effectiveness/implementation hybrid trial><effectiveness/implementation trial><eleven year old><eleven years of age><emergency service><engagement with communities><evidence base><experience><fatal attempt><fatal suicide><feasibility testing><heterogeneous population><implementation outcomes><implementation science><implementation trial><improved><improved outcome><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><inequality in access><inequity in access><inequity in accessibility><intent to die><intervention research><interventional research><interventional study><interventions research><obstacle to care><obstacle to health care><parent><peer><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><physical conditioning><physical health><population diversity><programs><randomized control trial><recruit><repetitive behavior><research into practice><research to practice><safety net><scale up><self awareness><self esteem><self knowledge><seventeen year old><seventeen years of age><suicidal behavior><suicidal ideation><suicidal thinking><suicide behavior><suicide ideation><suicides><symptom treatment><symptomatic treatment><thoughts><thoughts about suicide><tool><treat symptom><treatment as usual><usual care><verbal><youth age><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder>

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Guillermo Gonzalez-Burgos

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$437,250

FY 2026

Project Title

Parvalbumin neuron diversity and plasticity in primary visual and prefrontal cortical areas

Grant Number:

1R21MH142912-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Parvalbumin interneurons (PVIs) are essential for regulating cortical network activity, playing key roles in both the primary visual cortex (V1) and in the prefrontal cortex (PFC). PVIs have been implicated in schizophrenia, bipolar disorder, autism, and major depression, with transc...

Research Terms

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Adam Christopher Roberts

CALIFORNIA STATE UNIVERSITY FULLERTON, FULLERTON, CA

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$400,398

FY 2026

Project Title

Cellular and molecular mechanisms of BPA-induced disruption of neurodevelopment

Grant Number:

1R15ES036712-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/7/2026

End Date:

4/7/2029

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Neurodevelopmental disorders such as autism spectrum disorder present a particular challenge due to the complex nature of clinical symptoms and etiology. To understand and dissect human disorders, animal models provide valuable insights that can lead to novel therapeutics and/or driv...

Research Terms

<0-11 years old><ASD><Active Oxygen><Agonist><Amniotic Fluid><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Aqua Amnii><Autism><Autistic Disorder><Behavior><Behavioral><Behavioral Assay><Biologic Models><Biological><Biological Models><Birth><Blood Plasma><Body Fluids><Brachydanio rerio><Brain><Brain Nervous System><Breast Milk><Breastmilk><Cancers><Causality><Cell Communication and Signaling><Cell Signaling><Child><Child Youth><Childhood><Children (0-21)><Chromatin><Clinical><Complement><Complement Proteins><Complex><Comprehension><Danio rerio><Developing fetus><Development><Developmental Process><Diagnosis><Disease><Disorder><Dysfunction><Early Infantile Autism><Encephalon><Endocrine disruption><Etiology><Event><Excitatory Synapse><Exposure to><Fecundability><Fecundity><Fertility><Fetal Development><Fishes><Functional disorder><Goals><High Throughput Assay><Human><Human Figure><Human Milk><Human Mother's Milk><Human body><Infantile Autism><Inhibitory Synapse><Intracellular Communication and Signaling><Investigation><Kanner's Syndrome><Larva><Liquor Amnii><Malignant Neoplasms><Malignant Tumor><Mammary Gland Milk><Maternal Exposure><Measures><Mediating><Metabolic><Mice><Mice Mammals><Model System><Modeling><Modern Man><Molecular><Mother's Milk><Murine><Mus><Nature><Nervous System><Neural Development><Neurodevelopmental Disorder><Neurologic Body System><Neurologic Organ System><Neurological Development Disorder><Oxygen Radicals><Parturition><Pathogenesis><Pathway interactions><Physiology><Physiopathology><Plasma><Plasma Serum><Pro-Oxidants><Problem behavior><Production><Productivity><Public Health><Reactive Oxygen Species><Receptor Protein><Reporting><Reticuloendothelial System, Serum, Plasma><Rodent><Rodentia><Rodents Mammals><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Structure><Symptoms><Synapses><Synaptic><System><Technology><Therapeutic><Toxin><Urine><Zebra Danio><Zebra Fish><Zebrafish><analog><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavioral problem><biologic><biological signal transduction><bisphenol A><causation><complementation><critical period><developmental><diphenylolpropane><disease causation><endocrine disrupting><experiment><experimental research><experimental study><experiments><exposed in utero><fetal><fetal exposure><habituation><high throughput screening><human disease><in utero><in utero exposure><insight><intra-uterine environmental exposure><intrauterine environmental exposure><kids><malignancy><maternal milk><model of animal><model organism><mouse model><murine model><neoplasm/cancer><nervous system development><neural><neural circuit><neural circuitry><neurobehavioral><neurocircuitry><neurodevelopment><neurodevelopmental disease><neurophysiological><neurophysiology><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathophysiology><pathway><pediatric><postsynaptic><prenatal exposure><prenatally exposed><receptor><repetitive behavior><response><social defects><social deficits><social disorders><social dysfunction><synapse><synaptic circuit><synaptic circuitry><tool><youngster><zebrafish development>

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Peter B Crino

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$273,597

FY 2026

Project Title

KPTN Loss and Megalencephaly: mTOR Activation as Therapeutic Target

Grant Number:

4R37NS125632-05

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Mutations in select mTOR pathway genes (MPG) are associated with megalencephaly (ME) and/or hemimegalencephaly (HME) including MTOR (Smith-Kingsmore syndrome, ME), STRADA (Pretzel syndrome, ME), PI3KCA (ME/HME), AKT3 (HME), PTEN (ME), DEPDC5 (HME) and RHEB (HME). Autosomal recessive germline variant...

Research Terms

<0-11 years old><19q13.32><21+ years old><AKT3><AKT3 gene><ASD><Abnormal Cell><Adult><Adult Human><Affect><Age><Amaze><Amino Acids><Amish><Assay><Autism><Autistic Disorder><Bioassay><Biologic Models><Biological Assay><Biological Models><Birth><Brain><Brain Nervous System><Brain imaging><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Caring><Cas nuclease technology><Cell Communication and Signaling><Cell Growth in Number><Cell Locomotion><Cell Migration><Cell Movement><Cell Multiplication><Cell Proliferation><Cell Signaling><Cell Size><Cellular Migration><Cellular Morphology><Cellular Motility><Cellular Proliferation><Child><Child Youth><Children (0-21)><Clinic><Clinical><Clinical Data><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Collaborations><Communities><Complex><DKFZP434N0250><DNA mutation><Data><Data Bases><Databases><Decreased Muscle Tone><Dedications><Development><Developmental Delay><Developmental Delay Disorders><Diagnostic><EEG><Early Infantile Autism><Electroencephalogram><Electroencephalography><Encephalon><Enrollment><Epilepsy><Epileptic Seizures><Epileptics><Exhibits><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Family><General Population><General Public><Generalized Growth><Genes><Genetic Change><Genetic defect><Genetic mutation><Genome><Genotype><Germ-Line Mutation><Growth><Head circumference><Hereditary Mutation><Histopathology><Hospitals><Human><Hypomyotonia><Hypotonia><In Vitro><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><International><Intervention><Intracellular Communication and Signaling><Investigation><Kanner's Syndrome><Laboratories><Life><Link><MMAC1><MMAC1 protein><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measurement><Mechanistic Target of Rapamycin><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medicine><Megalencephaly><Mice><Mice Mammals><Model System><Modeling><Modern Man><Motility><Mouse Strains><Murine><Mus><Muscle Hypotony><Muscle Tone Poor><Muscle hypotonia><Muscular Hypotonia><Mutated in Multiple Advanced Cancers 1><Mutation><NMR Imaging><NMR Tomography><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurologic><Neurological><Neurons><Neuropsychologic Tests><Neuropsychological Tests><Nuclear Magnetic Resonance Imaging><Ohio><Operative Procedures><Operative Surgical Procedures><PHTS gene><PHTS protein><PKBG><PMSE Syndrome><PRKBG><PTEN><PTEN gene><PTEN protein><PTEN1><Parents><Parturition><Pathogenicity><Pathway interactions><Patients><Pennsylvania><Phenotype><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Plant Leaves><Play><Polyhydramnios, megalencephaly, and symptomatic epilepsy><Population><Pretzel Syndrome><Proliferating><RAC-GAMMA><RAFT1><Rapamune><Rapamycin><Refractory><Registries><Research><Role><Running><Seizure Disorder><Seizures><Signal Transduction><Signal Transduction Systems><Signaling><Sirolimus><Smith-Kingsmore syndrome><Specialist><Specific Child Development Disorders><Surgical><Surgical Interventions><Surgical Procedure><Syndrome><Thick><Thickness><Tissue Growth><Variant><Variation><Zeugmatography><adulthood><ages><aminoacid><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><autosome><biological signal transduction><brain overgrowth><brain size><brain visualization><cell morphology><cell motility><clinical center><cohort><college><collegiate><data base><developmental><enroll><epilepsia><epileptiform><epileptogenic><genome mutation><germ-line defect><germline variant><global developmental delay><hemimegalencephaly><in vivo><in vivo Model><infancy><infantile><inhibitor><intellectual and developmental disability><kids><leaf><limited intellectual functioning><loss of function><mTOR><mTOR inhibition><mammalian target of rapamycin><mouse model><murine model><mutated in multiple advanced cancers 1 protein><nerve stem cell><neural imaging><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neuro-imaging><neurogenic progenitors><neurogenic stem cell><neuroimaging><neurological imaging><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuropathologic><neuropathological><neuropathology><neuroprogenitor><non-speaking><non-verbal><non-vocal><ontogeny><parent><pathway><phosphatase and tensin homologue on chromosome ten><postnatal><prevent><preventing><progenitor and neural stem cells><prospective><protein complex><response><social role><surgery><therapeutic target><youngster>

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Alex Wang

HARVARD MEDICAL SCHOOL, BOSTON, MA

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$76,300

FY 2026

Project Title

Developmental Activity and Function of Layer 5 Cortical Circuits Following Early Postnatal Reorganization

Grant Number:

1F32NS146097-01

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2026

End Date:

2/28/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The precise formation of circuits in the cerebral cortex, involving both excitatory pyramidal neurons (PNs) and inhibitory interneurons (INs), is crucial for proper brain function, with disruptions in this process being implicated in neurodevelopmental disorders such as autism, epile...

Research Terms

<2-photon><2-photon microscopy><21+ years old><ASD><Adult><Adult Human><Affect><Age><Animals><Area><Autism><Autistic Disorder><Automobile Driving><Behavior><Behavioral><Birth><Brain><Brain Nervous System><Calcium><Cell Body><Cells><Cerebral cortex><Connector Neuron><Coupled><Cyclic Somatostatin><Darkness><Detection><Development><Disease><Disorder><Early Infantile Autism><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Evolution><Exhibits><Eye><Eyeball><Goals><Growth Hormone Inhibiting Factors><Growth Hormone-Inhibiting Hormone><Image><Infantile Autism><Injections><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Kanner's Syndrome><Laboratories><Logic><Methods><Mice><Mice Mammals><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Parturition><Pattern><Perception><Performance><Population><Primary visual cortex><Process><Pyramidal neuron><Research Training><SRIH><SRIH-14><Schizophrenia><Schizophrenic Disorders><Seizure Disorder><Shapes><Sight><Somatostatin><Somatostatin-14><Somatotropin Release Inhibiting Factors><Somatotropin Release-Inhibiting Hormone><Specific qualifier value><Specificity><Specified><Striate Cortex><Striate area><Synapses><Synaptic><Time><Viral><Virus><Vision><Visual><Visual Evoked Potentials><Visual Evoked Response><Visual evoked cortical potential><Work><adult animal><adulthood><ages><area striata><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><calcium indicator><critical period><dark rear><dark rearing><dementia praecox><detection sensitivity><developmental><driving><epilepsia><epileptogenic><excitatory neuron><experience><genetic approach><genetic strategy><growth hormone release inhibiting factor><hippocampal pyramidal neuron><imaging><improved><information processing><innervation><insight><mature animal><nerve supply><neural><neurodevelopmental disease><neuronal><neuronal patterning><novel><post-natal development><postnatal><postnatal development><prevent><preventing><response><retinotopic map><schizophrenic><synapse><training project><two photon excitation microscopy><two photon microscopy><two-photon><visual excitation><visual field map><visual function><visual map><visual stimulus>

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Rebekah Elise Townsley

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$49,538

FY 2026

Project Title

Investigating the role of NLGN3 in autism spectrum disorder and sleep disruptions

Grant Number:

5F31MH139286-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT: Autism spectrum disorder (ASD) is a common neurodevelopmental disorder that is highly comorbid with sleep disruptions. Although 40-80% of children diagnosed with ASD exhibit sleep disruptions, the etiology of this association remains largely unknown. However, through genome wide associatio...

Research Terms

<0-11 years old><ASD><Adhesion Molecule><Affect><Alleles><Allelomorphs><Assay><Autism><Autistic Disorder><Axon Terminals><Behavior><Behavior-Related Disorder><Behavior-Related Problem><Behavioral><Behavioral Assay><Binding><Bioassay><Biological Assay><Causality><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Child><Child Youth><Children (0-21)><Circadian Rhythms><Classification><Coloring Agents><Complementary DNA><Courtship><Data Bases><Databases><Defect><Development><Diagnosis><Disease><Disorder><Drosophila><Drosophila genus><Dyes><Early Infantile Autism><Endocytosis><Endocytosis Inhibition><Etiology><Exhibits><Family><Female><Flies><Foundations><GWA study><GWAS><Gene Family><Genes><Genetic Heterogeneity><Glutamates><Goals><Grooming><Hereditary><Heterozygote><Human><Impairment><Individual><Infantile Autism><Inherited><KI mice><Kanner's Syndrome><Knock-in Mouse><L-Glutamate><Lead><Length><Lifestyle-Related Disorder><Lifestyle-Related Problem><Lifestyle-related condition><Link><Locomotion><Measures><Methods><Mice><Mice Mammals><Modern Man><Molecular><Molecular Interaction><Morphology><Murine><Mus><Myoneural Junction><Nervous System Diseases><Nervous System Disorder><Neural Transmission><Neurites><Neurodevelopmental Disorder><Neurologic Disorders><Neurological Development Disorder><Neurological Disorders><Neuromuscular Junction><Nyctohemeral Rhythm><Ortholog><Orthologous Gene><Pathogenesis><Patients><Pattern><Pb element><Phenotype><Play><Population><Presynaptic Nerve Endings><Presynaptic Terminals><Proteins><Receptor Protein><Research><Role><Sleep><Sleep Deprivation><Sleep Disorders><Sleep disturbances><Structure><Synapses><Synaptic><Synaptic Boutons><Synaptic Terminals><Synaptic Transmission><Synaptic Vesicles><Synaptic plasticity><Systematics><Testing><Therapeutic><Twenty-Four Hour Rhythm><United States><Variant><Variation><Vesicle><aberrant sleep><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior study><behavioral study><cDNA><causation><cell adhesion protein><circadian process><circadian rhythmicity><co-morbid><co-morbidity><comorbidity><daily biorhythm><data base><deficient sleep><developmental><disease causation><disrupted sleep><disturbed sleep><fly><fruit fly><gain of function><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><glutamatergic><heavy metal Pb><heavy metal lead><heterozygosity><impaired sleep><in vivo><inadequate sleep><insight><insufficient sleep><interest><irregular sleep><kids><knockin mice><loss of function><male><model organism><mouse model><murine model><mutant><neural><neural circuit><neural circuitry><neurocircuitry><neurodevelopmental disease><neuroligin 3><neurological disease><novel><overexpress><overexpression><postsynaptic><presynaptic><receptor><repetitive behavior><sleep abnormalities><sleep behavior><sleep debt><sleep deficiency><sleep deficit><sleep diseases><sleep disruption><sleep dysfunction><sleep dysregulation><sleep habit><sleep illness><sleep insufficiency><sleep loss><sleep problem><sleep/wake behavior><sleep/wake disruption><sleep/wake disturbance><social communication impairment><social defects><social deficits><social disorders><social dysfunction><social role><synapse><synapse formation><synaptic circuit><synaptic circuitry><synaptogenesis><uptake><variant of interest><whole genome association analysis><whole genome association study><youngster><♀><♂>

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Alexander Pope

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$36,752

FY 2026

Project Title

Mechanisms of Setd2 in cortical circuit function: Convergence with Fragile X Syndrome

Grant Number:

5F31NS132473-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/5/2024

End Date:

11/4/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Post-translational modifications of histones, including methylation, are critical for regulating gene expression and maintaining homeostasis. In neurons, dysregulation of histone methylation is associated with neurodevelopmental disorders such as autism spectrum disorders (ASD). SET Domain Containin...

Research Terms

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Susanna Mierau

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 34/100

Solid budget

Active award

Career award

$257,731

FY 2026

Project Title

Restoring Cortical Network Function in Rett Syndrome

Grant Number:

5K02NS131521-03

Activity Code:

K02

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT Autism spectrum and related neurodevelopmental disorders are thought to arise from widespread mild synaptic dysfunction that leads to an altered trajectory of brain network development (Johnson et al., 2015). In Rett syndrome (RTT), a debilitating neurodevelopmental disorder...

Research Terms

<0-11 years old><21+ years old><3-D modeling><3D modeling><ASD><Adult><Adult Human><Affect><Age Months><Air><Allogenic><Autism><Autistic Disorder><Behavioral><Birth><Brain><Brain Nervous System><Calcium><Case Study><Case-Base Studies><Cell Body><Cell model><Cells><Cellular model><Cerebroatrophic Hyperammonemia><Cerebrum><Child><Child Youth><Children (0-21)><Cognition><Cognition Disorders><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Computational toolkit><Connector Neuron><DNA Therapy><DNA mutation><Data><Defect><Development><Disturbance in cognition><Dysfunction><E-stim><Early Infantile Autism><Electric Stimulation><Encephalon><Ensure><Family><Female><Functional disorder><Funding><Future><Gene Transfer Clinical><Generations><Genes><Genetic Change><Genetic Intervention><Genetic defect><Genetic mutation><Goals><Human><Image><Impaired cognition><Impairment><In Vitro><Independent Scientist Award><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><K02 Award><Kanner's Syndrome><Language><Lead><Life><Liquid substance><Lyonization><MeCP-2 protein><MeCP2><MeCP2 protein><Mediator><Methyl CpG binding protein MeCP2><Methyl-CpG-Binding Protein 2><Methyl-DNA binding protein MECP2><Mice><Mice Mammals><Microelectrodes><Miniaturized Electrodes><Modeling><Modern Man><Motor><Murine><Mus><Mutation><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><NMDA Receptor-Ionophore Complex><NMDA Receptors><Necrosis><Necrotic><Nerve Cells><Nerve Unit><Neural Cell><Neural Transmission><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Organoids><Outcome><Parturition><Parvalbumins><Patients><Pb element><Physiopathology><Preparation><Research><Rett Disorder><Rett Syndrome><Sensory><Sight><Symptoms><Synapses><Synaptic><Synaptic Transmission><Testing><Time><Translating><Vision><Work><X Chromosome><X Inactivation><X-Chromosome Inactivation><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><boys><brain cell><case report><cell type><cerebral><cognitive disease><cognitive disorder><cognitive dysfunction><cognitive function><cognitive loss><cognitive syndrome><computational toolbox><computational tools><computational toolset><computerized tools><decrease disability><decrease in disability><density><developmental><disability reduction><early childhood><electrostimulation><excitatory neuron><fluid><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genome mutation><genomic therapy><girls><heavy metal Pb><heavy metal lead><imaging><improved><in vitro Model><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><infancy><infantile><information processing><inhibitory neuron><insight><kids><laser capture microdissection><lessen disability><life span><lifespan><liquid><loss of function mutation><minimize disability><mitigate disability><mouse model><murine model><network dysfunction><neurodevelopmental disease><neuron development><neuronal><neuronal circuit><neuronal circuitry><neuronal development><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapeutics><new therapy><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapeutics><novel therapy><novel therapy approach><novel therapy target><optogenetics><pathophysiology><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient-derived pluripotent stem cells><pharmacologic><premature><prematurity><preparations><prevent><preventing><reduction in disability><scRNA sequencing><scRNA-seq><screening><screenings><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><slow disability><social><synapse><three-dimensional modeling><tool><visual function><youngster><♀>

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Alejandra Ines Romero Morales

LIEBER INSTITUTE, INC., BALTIMORE, MD

Exploratory lead · 34/100

Training-friendly

Active award

$79,348

FY 2026

Project Title

Investigating the effects of TCF4 mutations during oligodendrocyte development and maturation in a human-derived model of autism spectrum disorder

Grant Number:

5F32MH135665-02

Activity Code:

F32

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/12/2024

End Date:

12/11/2027

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Project Abstract

Project Summary/Abstract Pitt-Hopkins Syndrome (PTHS) is a rare form of autism spectrum disorder (ASD) characterized by developmental delay, breathing abnormalities, seizure, lack of speech, and abnormal facies. PTHS is caused by de novo mutations in Transcription Factor 4 (TCF4), a key transcriptio...

Research Terms

<2-dimensional><3-D><3-Dimensional><3D><ASD><ASD patient><Antiheparin Factor><Antimorphic mutation><Area><Assay><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Axon><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biochemical><Biochemistry><Biological><Biological Assay><Biological Chemistry><Blood Platelet Factor IV><Blood platelet factor 4><Brain><Brain Nervous System><Breathing><Cell Body><Cell Death><Cell Line><CellLine><Cells><Chemical Fractionation><Chemokine (C-X-C motif) Ligand 4><Clinical><Co-Immunoprecipitations><Collection><Corpus Callosum><Corpus Callosums><DNA mutation><Defect><Development><Developmental Delay><Developmental Delay Disorders><Diameter><Disease><Disorder><Dominant Negative><Dominant-Negative Mutant><Dominant-Negative Mutation><Drug Screening><Drug Therapy><Drugs><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><FRACN><Face><Facies><Factor 4><Family><Fellowship><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Fractionation><Fractionation Radiotherapy><Fumarates><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><Heparin Neutralizing Protein><Human><Image><Immunofluorescence><Immunofluorescence Immunologic><In Vitro><Infantile Autism><Investigators><Kanner's Syndrome><Laboratories><Medication><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutation><Neurodevelopmental Disorder><Neurological Development Disorder><Neurophysiology / Electrophysiology><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><PF4 Gene><Patients><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phenotype><Pitt-Hopkins syndrome><Platelet Factor 4><Population><Process><Progenitor Cells><Proliferating><Proteins><Protocol><Protocols documentation><QOL><Quality of life><Rapid screening><Recombinant Platelet Factor 4><Recovery of Function><Regulation><Research Personnel><Researchers><Respiratory Aspiration><Respiratory Inspiration><SCYB4><Seizures><Specific Child Development Disorders><Specific qualifier value><Specified><Speech><Strains Cell Lines><System><Testing><Therapeutic><Therapeutic Intervention><Transcription Factor Proto-Oncogene><Transcription factor genes><Translational Research><Translational Science><Transmission Electron Microscopy><Variant><Variation><Work><autism model><autism spectral disorder><autism spectrum disorder><autistic patient><autistic spectrum disorder><biologic><cell immortalization><cell type><cultured cell line><de novo mutation><de novo variant><density><developmental><differentiation protocol><disease causing variant><disease-causing allele><disease-causing mutation><drug intervention><drug treatment><drug/agent><efficacy testing><electrophysiological><faces><facial><functional recovery><gamma-Thromboglobulin><gene signatures><genetic signature><genome mutation><human derived model><human derived platform><human derived system><human like model><human like platform><human like system><human specific alternative><human specific model><human specific platform><human specific system><human-based alternative><human-based biological models><human-based model><human-based nonanimal models><human-based platform><human-based research><human-based system><human-based tools><human-centered model><human-centered platform><human-centered research><human-centered system><human-focused research><human-relevant alternative><human-relevant model><human-relevant platform><human-relevant system><iPS><iPSC><iPSCs><imaging><improved><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cells derived from patients><induced pluripotent stem cells from patients><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><inspiration><intervention therapy><model of autism spectrum disorder><mouse model><multi-electrode arrays><multielectrode arrays><murine model><mutant><myelination><necrocytosis><neural imaging><neuro-imaging><neurodevelopmental disease><neuroimaging><neurological imaging><neuropsychiatric disease><neuropsychiatric disorder><oligodendrocyte lineage><oligodendrocyte precursor><oligodendrocyte precursor cell><oligodendrocyte progenitor><oligodendrocyte stem cell><pathogenic allele><pathogenic variant><patient derived human iPS><patient derived human iPSC><patient derived human induced pluripotent stem cell><patient derived iPS><patient derived iPSC><patient derived induced pluripotent cells><patient derived induced pluripotent stem cells><patient with ASD><patient-derived pluripotent stem cells><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><platelet factor IV><progenitor cell model><progenitor cell pool><progenitor cell population><progenitor model><progenitor pool><progenitor population><programs><screening><screenings><self-renew><self-renewal><spheroids><stem and progenitor cell model><stem and progenitor cell population><stem cell based model><stem cell derived model><stem cell model><stem cell pool><stem cell population><stem cells><substantia alba><three dimensional><transcription factor><translation research><translational investigation><two-dimensional><white matter>

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Kimberly Summer Bress

VANDERBILT UNIVERSITY, Nashville, TN

Exploratory lead · 34/100

Training-friendly

Active award

$54,538

FY 2026

Project Title

Sensorimotor Control of Facial Expression in Autism

Grant Number:

5F30MH136677-02

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

11/1/2024

End Date:

10/31/2027

Why this may be worth a closer look

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Project Abstract

PROJECT SUMMARY Facial expression is a complex sensorimotor behavior involving precise contraction of the facial muscles guided by dynamic sensory and proprioceptive feedback. Atypical facial expressivity is a common characteristic of autism that impairs interpersonal communication and hinders the r...

Research Terms

<21+ years old><ASD><Address><Adult><Adult Human><Affective Disorders><Anxiety Disorders><Area><Autism><Autistic Disorder><Behavior><Behavioral><Brain><Brain Nervous System><Brain imaging><Brain region><Causality><Characteristics><Clinical><Clinical assessments><Collection><Communication Barriers><Community Networks><Complex><Data><Data Set><Development><Early Infantile Autism><Emotional><Emotions><Encephalon><Esthesia><Etiology><Evidence based intervention><Eye><Eyeball><Face><Facial Expression><Facial Muscles><Feedback><Functional MRI><Functional Magnetic Resonance Imaging><Goals><Graph><Impairment><Individual><Infantile Autism><Interpersonal Communication><Intervention><Kanner's Syndrome><Laboratories><Measures><Mental Health><Mental Hygiene><Mood Disorders><Motivation><Motor><Nonverbal Communication><Outcome><Pain><Painful><Pathway interactions><Pattern><Personal Communication><Psychological Health><Publishing><Rest><Sampling><Sensation><Sensorimotor functions><Sensory><Social Development><Speech><Structure><System><Testing><Work><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><autism spectral disorder><autism spectrum disorder><autistic><autistic adult><autistic individuals><autistic people><autistic spectrum disorder><behavior measurement><behavioral measure><behavioral measurement><brain visualization><causation><clinical relevance><clinically relevant><co-morbid><co-morbidity><comorbidity><data exchange><data transfer><data transmission><developmental><disease causation><emotional stimulus><experience><fMRI><face expression><faces><facial><feeding><gaze><improved><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><motor control><neural><neural imaging><neuro-imaging><neuroimaging><neurological imaging><non-verbal communication><open data><open science><open-source data><paralinguistic behavior><pathway><peer><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><prevent><preventing><skills><social><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target>

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Jada Summerville

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Exploratory lead · 34/100

Training-friendly

Active award

$50,114

FY 2026

Project Title

Non-Canonical Roles for Cell-Adhesion Molecules in Presynaptic Assembly

Grant Number:

5F31NS134338-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/15/2023

End Date:

12/14/2026

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Project Abstract

PROJECT SUMMARY The proper formation of synapses is integral to the function of neural circuits. Disruptions in synaptogenesis during early development can lead to neurodevelopmental disorders, such as autism or intellectual disability. Yet despite decades of study, precisely how synapses form, matu...

Research Terms

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Noah Emery Pollak Milman

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Exploratory lead · 34/100

Training-friendly

Active award

$50,114

FY 2026

Project Title

Role of early-life sleep and sensory environment in shaping the development of affiliative behavior and PV-interneurons in the somatosensory cortex of the highly social prairie vole.

Grant Number:

5F31MH136684-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2027

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Project Abstract

Project Summary Early life sleep is fundamental to the development of affiliative behavior, defined as any behavioral display that promotes positive social engagement. Autism spectrum disorder (ASD) is characterized by persistent changes in social behavior, sensory sensitivity, and sleep disruption....

Research Terms

<12-20 years old><21+ years old><ASD><Acceleration><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Animals><Appearance><Autism><Autistic Disorder><Behavior><Behavioral><Benchmarking><Best Practice Analysis><Brain><Brain Nervous System><Brain region><Cell Body><Cell Count><Cell Number><Cell-Extracellular Matrix><Cells><Clinical><Common Rat Strains><Complex><Computational toolkit><Connector Neuron><Cues><Data><Development><Disease><Disorder><ECM><Early Infantile Autism><Encephalon><Environment><Equilibrium><Extracellular Matrix><Extracellular Structure><Familiarity><Fast-Wave Sleep><Female><Foundations><Goals><Home><Housing><Impairment><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Kanner's Syndrome><Laboratory Rat><Laboratory mice><Life><Manuals><Maps><Mediating><Mice><Mice Mammals><Microtus><Modeling><Molecular><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Pair Bond><Paradoxical Sleep><Partner in relationship><Parvalbumins><Pathogenesis><Phenotype><Proxy><REM Sleep><Randomized><Rat><Rats Mammals><Rattus><Rhombencephalic Sleep><Rodent><Rodentia><Rodents Mammals><Role><Same-sex><Sensory><Shapes><Siblings><Side><Sleep><Sleep Deprivation><Sleep disturbances><Social Behavior><Social Development><Social Interaction><Somatosensory Cortex><Staining method><Stains><Structure><Testing><Therapeutic><Time><Touch><Touch sensation><Vole><Weaning><Work><aberrant sleep><adequate sleep><adolescence (12-20)><adulthood><affiliative behavior><autism spectral disorder><autism spectrum disorder><autistic children><autistic spectrum disorder><balance><balance function><behavioral impairment><benchmark><brain cell><brain tissue><cell type><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><compare to control><comparison control><computational toolbox><computational tools><computational toolset><computerized tools><critical period><deficient sleep><developmental><disrupted sleep><disturbed sleep><dreaming sleep><environment enrichment><environment enrichment for laboratory animals><environmental enrichment><environmental enrichment for laboratory animals><excitatory neuron><experience><field mouse><homes><impaired behavior><impaired sleep><inadequate sleep><inhibitory neuron><insight><insufficient sleep><irregular sleep><juvenile><juvenile human><male><mate><neural circuit><neural circuitry><neurocircuitry><neurodevelopment><neurodevelopmental disease><neuronal><novel><postnatal><prairie vole><pre-clinical research><preclinical research><preference><randomisation><randomization><randomly assigned><rapid eye movement sleep><sensory cortex><sex><sleep control><sleep debt><sleep deficiency><sleep deficit><sleep disruption><sleep dysregulation><sleep insufficiency><sleep loss><sleep regulation><sleep/wake disruption><sleep/wake disturbance><sleep/wake regulation><social><social engagement><social involvement><social participation><social role><sociobehavior><sociobehavioral><somesthetic sensory cortex><synaptic circuit><synaptic circuitry><tactile sensation><timeline><♀><♂>

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Ruiling Zhang

UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 34/100

Training-friendly

Active award

$49,538

FY 2026

Project Title

Uncovering DIP-α signaling pathways underlying circuit assembly

Grant Number:

5F31NS136004-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2024

End Date:

11/30/2028

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Project Abstract

PROJECT SUMMARY / ABSTRACT All animal behaviors and cognition require precise assembly of neural circuits. Despite a highly complex environment in the central nervous system, neurons faithfully recognize their precise partners and establish synaptic connections. Precise connectivity has been well de...

Research Terms

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Michelle W. Wu

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 34/100

Training-friendly

Active award

$46,064

FY 2026

Project Title

Role of Intracortical Mechanisms Vs. Bottom-Up Influences in Developmental Desynchronization of Cortical Network Activity

Grant Number:

5F30HD117619-02

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

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Project Abstract

ABSTRACT Studying how cortical circuits mature is critical to understanding neurodevelopmental conditions as proper wiring of these circuits is important for perception and cognition. Initially, spontaneous neuronal activity in the developing neocortex is characterized by intermittent, brief bursts ...

Research Terms

<2-photon><21+ years old><ASD><Acute><Adult><Adult Human><Autism><Autistic Disorder><Automobile Driving><Axon><Brain><Brain Nervous System><Brain region><Calcium><Candidate Disease Gene><Candidate Gene><Cell Nucleus><Cerebral cortex><Chronic><Cochlea><Cochlear Organ><Code><Coding System><Cognition><Complex><Connector Neuron><Cortical Desynchronizations><DNA mutation><Development><Early Infantile Autism><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Escalante syndrome><Event><Exhibits><Fragile X><Fragile X Syndrome><Gene Expression><Genetic><Genetic Change><Genetic defect><Genetic mutation><Human><Image><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Interruption><KO mice><Kanner's Syndrome><Knock-out Mice><Knockout Mice><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Mediating><Metabolic><Mice><Mice Mammals><Modality><Modern Man><Motor Cortex><Murine><Mus><Mutation><Neocortex><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neurons><Nucleus><Null Mouse><Parvalbumins><Pathway interactions><Pattern><Perception><Play><Population><Process><Renpenning syndrome 2><Retina><Role><Runaway><Secondary to><Seizure Disorder><Sense Organs><Sensory><Single-Nucleus Sequencing><Somatosensory Cortex><Testing><Thalamic structure><Thalamus><Time><Vibrissae><Whiskers><Work><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><adulthood><autism spectral disorder><autism spectrum disorder><autism-fragile X (AFRAX) syndrome><autistic spectrum disorder><candidate identification><cell type><developmental><driving><epilepsia><epileptogenic><excitatory neuron><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><genome mutation><homotypical cortex><imaging><in vivo><inhibitory neuron><insight><intellectual and developmental disability><isocortex><limited intellectual functioning><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><mouse model><murine model><neopallium><neural circuit><neural circuitry><neurocircuitry><neurodevelopment><neuronal><neuronal excitability><pathway><postnatal><sNuc-Seq><sensory cortex><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><somesthetic sensory cortex><spatial and temporal><spatial temporal><spatiotemporal><synaptic circuit><synaptic circuitry><thalamic><transcriptomics><two-photon>

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Kathleen Donovan

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Exploratory lead · 34/100

Training-friendly

Active award

$39,970

FY 2026

Project Title

Neuronal Primary Cilia Dysfunction in Tuberous Sclerosis Complex

Grant Number:

5F31NS141557-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

1/3/2025

End Date:

10/2/2028

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Project Abstract

Tuberous sclerosis complex (TSC) is a genetic disorder caused by heterozygous inactivating variants in TSC1 or TSC2. TSC is characterized by the growth of benign tumors in multiple organs, as well as neurological manifestations such as refractory epilepsy, autism spectrum disorder, and intellectual ...

Research Terms

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Ariel Hairston

HARVARD MEDICAL SCHOOL, BOSTON, MA

Exploratory lead · 34/100

Training-friendly

Active award

$37,996

FY 2026

Project Title

Activity-Dependent Circuit Integration of Somatostatin Interneuron Subtypes in the Developing Neocortex

Grant Number:

5F31NS135903-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

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Project Abstract

Project Summary The mammalian cortex consists of many transcriptionally distinct neuronal cell types connected in intricate circuits. Much work has shown that risk genes associated with developmental disorders such as schizophrenia, autism spectrum disorder, epilepsy and intellectual disorder encode...

Research Terms

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Amber Rose Stewart

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 34/100

Training-friendly

Active award

$37,810

FY 2026

Project Title

The role of subsynaptic nanoscale architecture in inhibitory synaptic plasticity

Grant Number:

5F31NS141320-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

2/1/2025

End Date:

11/30/2027

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Project Abstract

PROJECT SUMMARY Synaptic inhibition in the brain is critical for controlling neuronal circuit function, and its disruption underlies the pathology of multiple neurological, psychiatric, and neurodevelopment disorders including epilepsy, anxiety, autism, and schizophrenia. GABAergic inhibitory synaps...

Research Terms

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Rachel Oren

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 34/100

Training-friendly

Active award

$34,514

FY 2026

Project Title

Impact of CDKL5 deficiency on thalamocortical dynamics

Grant Number:

5F31EY035937-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2026

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Project Abstract

Project Summary CDKL5 Deficiency Disorder (CDD) is an X-linked genetic disorder caused by mutations in the cdkl5 (cyclin-dependent kinase-like 5) gene. Patients with CDD exhibit many features common to Autism Spectrum Disorder, but also frequently suffer from cortical visual impairment. Specificall...

Research Terms

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Nirao Mahesh Shah

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 32/100

Solid budget

Recent

Active award

$457,795

FY 2026

Project Title

A genetic strategy to identify neural circuits that regulate social attachment in prairie voles

Grant Number:

1R21MH141455-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

3/14/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT We form attachments at many levels of social interactions, including with spouses, family members, friends, and other members of the community. The neurobiological mechanisms that control the formation and maintenance of social attachment remain poorly understood. This is in...

Research Terms

<21+ years old><3' Untranslated Regions><3'UTR><ASD><AVPR1><AVPR1A><AVPR1A gene><Adult><Adult Human><Alleles><Allelomorphs><Antidiuretic Hormone><Autism><Autistic Disorder><Behavior><Behavioral><Biologic Models><Biological Models><Brain><Brain Nervous System><CRE Recombinase><CRISPR><CRISPR/Cas system><Cell Communication and Signaling><Cell Signaling><Clustered Regularly Interspaced Short Palindromic Repeats><Communities><Complex><Disease><Disorder><Early Infantile Autism><Encephalon><Engineering><Ensure><Enterobacteria phage P1 Cre recombinase><Failure><Family member><Fishes><Flies><Friends><Gene Modified><Genes><Genetic><Genetic Models><Germ Lines><Goals><Health><Human><Infantile Autism><Intracellular Communication and Signaling><Kanner's Syndrome><Knock-in><Maintenance><Mammalia><Mammals><Maps><Married Persons><Mediating><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mice><Mice Mammals><Microtus><Model System><Modeling><Modern Man><Molecular><Molecular Genetics><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Pathways><Neurocyte><Neurons><Neurosciences><Ocytocin><Organism><Oxytocin><Pair Bond><Pathway interactions><Personal Satisfaction><Pharmacological Study><Pharmacology Study><Physiology><Population><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Publishing><Receptor Protein><Recombinant Oxytocin><Reporter><Rodent><Rodentia><Rodents Mammals><Rupture><Schizophrenia><Schizophrenic Disorders><Siblings><Signal Transduction><Signal Transduction Systems><Signaling><Social Behavior><Social Controls><Social Interaction><Spouses><Tamoxifen><Testing><Therapeutic><Thirst><Transgenes><Transgenic Organisms><Transmission><Vasopressins><Viral><Vole><Work><adulthood><affiliative behavior><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><bacteriophage P1 recombinase Cre><beta-Hypophamine><biological signal transduction><cell type><chronic mental illness><dementia praecox><depression><design><designing><diagnostic approach><diagnostic strategy><experiment><experimental research><experimental study><experiments><field mouse><fly><gene modification><genetic approach><genetic strategy><genetically modified><healing><induced Cre><inducible Cre><knockin><living system><member><mental illness><neural><neural circuit><neural circuitry><neural network><neurobiological mechanism><neurocircuitry><neuronal><new technology><novel technologies><pathway><persistent mental illness><prairie vole><psychiatric illness><psychological disorder><receptor><schizophrenic><screening><screenings><serious mental disorder><serious mental illness><severe mental disorder><severe mental illness><social><social attachment><social bonding><sociobehavior><sociobehavioral><success><synaptic circuit><synaptic circuitry><tool><transgene><transgenic><transmission process><unpublished works><well-being><wellbeing>

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Cathleen M Lutz

JACKSON LABORATORY, BAR HARBOR, ME

Exploratory lead · 32/100

Solid budget

Recent

Active award

$433,867

FY 2026

Project Title

Interrogation of Neurological Pathologies Associated with Mutations in Kif1a

Grant Number:

5R33NS133266-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

2/28/2027

Project Abstract

PROJECT SUMMARY KAND (KIF1A-associated neurological disorder) is caused by mutations in the KIF1A gene - a microtubule- dependent motor protein that is responsible to transport cellular cargos in neurons. The majority of mutations are dominant missense mutations that cluster in the conserved motor d...

Research Terms

<0-11 years old><21+ years old><ASD><Academia><Address><Adult><Adult Human><Affect><Alleles><Allelomorphs><Atrophic><Atrophy><Autism><Autistic Disorder><Axonal Transport><Axoplasmic Transport><Biological Markers><Biology><Cell Body><Cells><Cessation of life><Child><Child Youth><Childhood><Childhood Neurological Disorder><Children (0-21)><Clinical><Communities><Cranial Nerve II><DNA><DNA mutation><Data><Death><Decreased Muscle Tone><Defect><Deoxyribonucleic Acid><Development><Developmental Delay><Developmental Delay Disorders><Diminished Vision><Disease><Disorder><Dysfunction><Early Infantile Autism><Functional disorder><Genes><Genetic><Genetic Change><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic defect><Genetic mutation><Goals><Heterozygote><Histology><Human><Hypomyotonia><Hypotonia><Industry><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intractable Epilepsy><Investigation><Kanner's Syndrome><Kinesin><Knowledge><Low Vision><Mice><Mice Mammals><Micro-tubule><Microcephaly><Microtubules><Missense Mutation><Modeling><Modern Man><Motor><Murine><Mus><Muscle Hypotony><Muscle Tone Poor><Muscle Weakness><Muscle hypotonia><Muscular Hypotonia><Muscular Weakness><Mutant Strains Mice><Mutation><Natural History><Nerve Cells><Nerve Unit><Nervous System><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neurologic><Neurologic Body System><Neurologic Disorders><Neurologic Organ System><Neurological><Neurological Disorder in Children><Neurological Disorders><Neurons><Optic Nerve><PNS Diseases><Partial Sight><Patients><Peptide Domain><Peripheral Nerve Diseases><Peripheral Nervous System Diseases><Peripheral Nervous System Disorders><Peripheral Neuropathy><Phase><Phenotype><Physiopathology><Preclinical Testing><Prevalence><Probability><Protein Domains><Proteins><Publishing><Recombinant DNA Technology><Reduced Vision><Refractory epilepsy><Reproducibility><Research><Research Resources><Resources><Route><Second Cranial Nerve><Seizures><Sight><Specific Child Development Disorders><Subnormal Vision><Tertiary Protein Structure><Testing><Therapeutic><Therapeutic Intervention><Time><Transgenic Mice><Validation><Vision><Visual impairment><Work><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><base editor><bio-markers><biologic marker><biomarker><cell type><design><designing><determine efficacy><developmental><dimer><disease diagnosis><disease phenotype><dominant genetic mutation><dominant mutation><drug-resistant epilepsy><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><gene replacement><genetically engineered><genome mutation><genotyped patients><heterozygosity><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><improved><induced human pluripotent stem cells><insight><intellectual and developmental disability><intervention therapy><kids><limited intellectual functioning><micrencephaly><microencephaly><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><mortality><mouse model><mouse mutant><murine model><mutation correction><neurological disease><neurological pathology><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><pathophysiology><pediatric><pre-clinical testing><prime editing><prime editor><protein function><respiratory><spatial and temporal><spatial temporal><spatiotemporal><therapeutic evaluation><therapeutic testing><validations><vision impairment><visual function><visually impaired><youngster>

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Hongbing Wang

MICHIGAN STATE UNIVERSITY, EAST LANSING, MI

Exploratory lead · 32/100

Solid budget

Recent

Active award

$416,859

FY 2026

Project Title

Probing nucleolus function in a mouse model of fragile X syndrome

Grant Number:

1R21MH140167-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/3/2026

End Date:

2/29/2028

Project Abstract

Project Summary Fragile X syndrome (FXS) stands as a prominent contributor to intellectual disability and autism spectrum disorders, stemming from mutations within the FMR1 gene. These mutations lead to severe reduction or absence of the FMRP protein. Despite extensive research, effective medical in...

Research Terms

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Brittany D. Chambers Butcher

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Exploratory lead · 32/100

Solid budget

Recent

Active award

$400,221

FY 2026

Project Title

BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLES

Grant Number:

5R24ES028533-09

Activity Code:

R24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2017

End Date:

10/31/2027

Project Abstract

Abstract The MARBLES (Markers of Autism Risk in Babies: Learning Early Signs) Study was launched in 2006 as the first epidemiologic cohort of younger siblings of children with autism spectrum disorders (ASD) to begin follow- up before and during the prenatal period when ASD is likely to originate. ...

Research Terms

<0-11 years old><ASD><Active Follow-up><Address><Affect><Application Context><Area><Autism><Autism Diagnosis><Autistic Disorder><Biological Markers><Caring><Causality><Child><Child Youth><Children (0-21)><Clinical><Clinical Services><Clinical assessments><Co(beta)-cyano-7''-(2-methyl)adeninylcobamide><Collection><Community Outreach><Data><Data Bases><Databases><Diet><Early Infantile Autism><Education><Educational aspects><Enrollment><Environmental Exposure><Environmental Factor><Environmental Health><Environmental Health Science><Environmental Risk Factor><Epidemiology><Equity><Espanol><Ethnic Origin><Ethnicity><Etiology><Evaluation of Risk Factors><Exposure Assessment><Family><Future><Gestation><Green space><History><Home><Immune><Immunes><Individual><Infantile Autism><Infrastructure><Investigators><Investments><Kanner's Syndrome><Language><Learning><Life Style><Lifestyle><Link><Lived experience><Lived experiences><Low Prevalence><Measurement><Measures><Mediator><Medical History><Methylation><Neighborhoods><Neural Development><Neurodevelopmental Disorder><Neurological Development Disorder><Nutrient><Outcome><Participant><Personal Medical History><Personal Medical History Epidemiology><Personal Satisfaction><Pregnancy><Prevalence><Protocol><Protocols documentation><Race><Races><Recording of previous events><Research Personnel><Research Resources><Research Specimen><Researchers><Resource Sharing><Resources><Risk><Sample Size><Sampling><Siblings><Site><Spanish><Specimen><Structural Racism><System><Update><Urbanicity><Visit><Work><active followup><autism biomarker><autism marker><autism spectral disorder><autism spectrum disorder><autistic children><autistic spectrum disorder><bilingual><bilingualism><bio-markers><biobank><biologic marker><biomarker><biorepository><causation><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical care><cohort><community engagement><contextual factors><data base><data sharing><deprivation><design><designing><diets><disease causation><early biomarkers><early detection biomarkers><early detection markers><economic indicator><engagement with communities><enroll><environmental justice><environmental risk><epidemiologic><epidemiological><experience><experienced discrimination><exposure analysis><exposure evaluation><exposure measurement><exposure profiling><exposure survey><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><factor A><follow up><follow-up><followed up><followup><greenspace><high risk><histories><homes><improved><indexing><kids><neurodevelopment><neurodevelopmental disease><participant enrollment><patient enrollment><perceived discrimination><perception of discrimination><population based><post-natal period><postnatal><postnatal period><prenatal><prospective><racial><racial background><racial origin><recruit><self-reported discrimination><shared data base><shared database><socio-demographic disparity><socio-demographic factors><socio-demographic inequality><socio-demographic inequity><socio-demographics><socio-economic><socio-economically><sociodemographic disparity><sociodemographic factors><sociodemographic inequality><sociodemographic inequity><sociodemographics><socioeconomically><socioeconomics><tool><unborn><walkability><walkable><web site><website><well-being><wellbeing><youngster>

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Rebecca Jean Schmidt

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Exploratory lead · 32/100

Solid budget

Recent

Active award

$400,221

FY 2026

Project Title

BUILDS MARBLES: Biorepository Upkeep and Infrastructure for Longitudinal Data Sharing for MARBLES

Grant Number:

5R24ES028533-09

Activity Code:

R24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/2017

End Date:

10/31/2027

Project Abstract

Abstract The MARBLES (Markers of Autism Risk in Babies: Learning Early Signs) Study was launched in 2006 as the first epidemiologic cohort of younger siblings of children with autism spectrum disorders (ASD) to begin follow- up before and during the prenatal period when ASD is likely to originate. ...

Research Terms

<0-11 years old><ASD><Active Follow-up><Address><Affect><Application Context><Area><Autism><Autism Diagnosis><Autistic Disorder><Biological Markers><Caring><Causality><Child><Child Youth><Children (0-21)><Clinical><Clinical Services><Clinical assessments><Co(beta)-cyano-7''-(2-methyl)adeninylcobamide><Collection><Community Outreach><Data><Data Bases><Databases><Diet><Early Infantile Autism><Education><Educational aspects><Enrollment><Environmental Exposure><Environmental Factor><Environmental Health><Environmental Health Science><Environmental Risk Factor><Epidemiology><Equity><Espanol><Ethnic Origin><Ethnicity><Etiology><Evaluation of Risk Factors><Exposure Assessment><Family><Future><Gestation><Green space><History><Home><Immune><Immunes><Individual><Infantile Autism><Infrastructure><Investigators><Investments><Kanner's Syndrome><Language><Learning><Life Style><Lifestyle><Link><Lived experience><Lived experiences><Low Prevalence><Measurement><Measures><Mediator><Medical History><Methylation><Neighborhoods><Neural Development><Neurodevelopmental Disorder><Neurological Development Disorder><Nutrient><Outcome><Participant><Personal Medical History><Personal Medical History Epidemiology><Personal Satisfaction><Pregnancy><Prevalence><Protocol><Protocols documentation><Race><Races><Recording of previous events><Research Personnel><Research Resources><Research Specimen><Researchers><Resource Sharing><Resources><Risk><Sample Size><Sampling><Siblings><Site><Spanish><Specimen><Structural Racism><System><Update><Urbanicity><Visit><Work><active followup><autism biomarker><autism marker><autism spectral disorder><autism spectrum disorder><autistic children><autistic spectrum disorder><bilingual><bilingualism><bio-markers><biobank><biologic marker><biomarker><biorepository><causation><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical care><cohort><community engagement><contextual factors><data base><data sharing><deprivation><design><designing><diets><disease causation><early biomarkers><early detection biomarkers><early detection markers><economic indicator><engagement with communities><enroll><environmental justice><environmental risk><epidemiologic><epidemiological><experience><experienced discrimination><exposure analysis><exposure evaluation><exposure measurement><exposure profiling><exposure survey><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><factor A><follow up><follow-up><followed up><followup><greenspace><high risk><histories><homes><improved><indexing><kids><neurodevelopment><neurodevelopmental disease><participant enrollment><patient enrollment><perceived discrimination><perception of discrimination><population based><post-natal period><postnatal><postnatal period><prenatal><prospective><racial><racial background><racial origin><recruit><self-reported discrimination><shared data base><shared database><socio-demographic disparity><socio-demographic factors><socio-demographic inequality><socio-demographic inequity><socio-demographics><socio-economic><socio-economically><sociodemographic disparity><sociodemographic factors><sociodemographic inequality><sociodemographic inequity><sociodemographics><socioeconomically><socioeconomics><tool><unborn><walkability><walkable><web site><website><well-being><wellbeing><youngster>

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Shuting Zheng

UNIVERSITY OF TEXAS AT AUSTIN, AUSTIN, TX

Exploratory lead · 30/100

Very recent

Active award

$249,430

FY 2026

Project Title

Tracking Depression and Associated Modifiable Social-Emotional Factors in Adolescent Girls with Autism

Grant Number:

5R00MH131841-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Adolescent girls with autism spectrum disorder (ASD) are at high risk for depression due to risk factors associated with female sex and ASD-related challenges. However, little empirical evidence is available on the psychosocial mechanisms of depression onset and change for g...

Research Terms

<10 year old><10 years of age><12-20 years old><14 year old><14 years of age><ASD><Acceleration><Adolescence><Adolescent><Adolescent Youth><Affective Disorders><Age><Autism><Autistic Disorder><Behavioral><Characteristics><Clinical><Coping Skills><Data><Data Analyses><Data Analysis><Data Collection><Development><Diagnosis><Early Infantile Autism><Ecological momentary assessment><Emotional><Emotional Depression><Emotional well being><Emotions><Ensure><Equation><Feels well><Female><Female Adolescents><Friendships><Goals><Impairment><Individual><Infantile Autism><Institution><Intervention><Investigators><Kanner's Syndrome><Learning><Life><Loneliness><Longitudinal Studies><Longitudinal Surveys><Maps><Measurement><Measures><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mentors><Methodology><Methods><Modeling><Mood Disorders><Moods><Motivation><NIMH><National Institute of Mental Health><Normal mental condition><Normal mental state><Normal psyche><Pattern><Phase><Population><Position><Positioning Attribute><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychological Impact><Psychological Well Being><Psychopathology><Puberty><Reporting><Research><Research Activity><Research Personnel><Research Resources><Researchers><Resources><Risk><Risk Factors><Sampling><Sense of well-being><Social Interaction><Strategic Planning><Symptoms><Techniques><Time><Training><Training Activity><Vulnerable Populations><Well in self><Youth><Youth 10-21><abnormal psychology><adolescence (12-20)><adolescent girl><adolescent mental health><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><age 10><age 10 years><age 14><age 14 years><ages><autism spectral disorder><autism spectrum disorder><autistic adolescent><autistic individuals><autistic people><autistic spectrum disorder><autistic youth><boys><commit suicide><completed suicide><coping strategy><customized therapy><customized treatment><data interpretation><depression><depression prevention><depression symptom><depressive><depressive symptoms><design><designing><develop therapy><developmental><early adolescence><effective intervention><emotion regulation><emotional experience><emotional factor><emotional regulation><emotional wellbeing><emotional wellness><experience><fourteen year old><fourteen years of age><girls><high risk><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><interest><intervention development><investigate longitudinal><juvenile><juvenile human><lonely><long-term study><longitudinal investigation><longitudinal outcome studies><longitudinal research><longitudinal research study><male><mental illness><mental well-being><mental wellbeing><mental wellness><mood symptom><negative mood><novel><patient specific therapies><patient specific treatment><peer victimization><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><programs><protective factors><psychiatric illness><psychological disorder><psychological wellbeing><psychological wellness><psychosocial><self wellness><sense of wellbeing><sex><skills><social><social relationships><study longitudinal><success><survey longitudinal><tailored medical treatment><tailored therapy><tailored treatment><ten year old><ten years of age><therapy development><training module><treatment development><treatment strategy><unique treatment><vulnerable group><vulnerable individual><vulnerable people><youth age><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder><♀><♂>

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Li Wang

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 30/100

Very recent

Active award

$249,000

FY 2026

Project Title

Identifying mechanisms ofsynapse maturation at neuronal subtype resolution

Grant Number:

4R00MH131832-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

12/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract The human brain function relies on the formation and maintenance of precise neural circuits among more than 100 subtypes of neurons. These circuits are mediated by synapses, the characteristics of which vary depending on neuronal subtype. Synaptic dysfunction plays a critica...

Research Terms

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Lina Marcela Carmona

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Exploratory lead · 30/100

Very recent

Active award

$224,101

FY 2026

Project Title

Dissection of Cell Type Specific Contributions to Motor Learning Circuits

Grant Number:

5R00NS127857-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2022

End Date:

3/31/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Abstract Whether riding your bike down a narrow path or reaching for your favorite cookie in a small box, many of our daily actions require skilled and accurate movements. However, to achieve proficiency, these motor skills must first be learned through the process of motor learning. Much wo...

Research Terms

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RAFAEL YUSTE

COLUMBIA UNIV NEW YORK MORNINGSIDE, NEW YORK, NY

Exploratory lead · 30/100

Very recent

Active award

$205,625

FY 2026

Project Title

Neuronal Ensemble Mechanisms of Behavior and Plasticity in a Cnidarian

Grant Number:

5R21NS135654-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Deciphering how neuronal ensembles, groups of coactive neurons, control specific behaviors and mental states is important for understanding behavioral disorders caused by mental or neurological condition such as Parkinson’s, Alzheimer’s, epilepsy, schizophrenia, and autism s...

Research Terms

<2-photon><AD dementia><ASD><Afferent Neurons><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Ammon Horn><Animals><Autism><Autistic Disorder><Basic Research><Basic Science><Behavior><Behavior Control><Behavior Disorders><Behavioral><Behavioral Manipulation><Behavioral Mechanisms><Biology><Brain><Brain Nervous System><Brain region><Buccal Cavity><Buccal Cavity Head and Neck><CNS plasticity><Caloric Intake><Causality><Cavitas Oris><Chemicals><Cnidaria><Cnidarians><Coelenterata><Complex><Cornu Ammonis><Data><Data Set><Disease><Disorder><Dissection><Dreams><Dysfunction><Early Infantile Autism><Encephalon><Energy Intake><Epilepsy><Epileptic Seizures><Epileptics><Etiology><Evolution><Feeding behaviors><Functional disorder><Goals><Hippocampus><Image><Impairment><Infantile Autism><Ingestive Behavior><Investigation><Kanner's Syndrome><Knowledge><Laser Electromagnetic><Laser Radiation><Lasers><Lead><Learning><Maps><Measures><Mechanisms of Behavior and Behavior Change><Mediating><Memory><Methods><Mouth><Movement><Muscle Cells><Myocytes><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Transmitter Substances><Nerve Unit><Nervous System><Network Analysis><Neural Cell><Neurocyte><Neurologic><Neurologic Body System><Neurologic Organ System><Neurological><Neuronal Plasticity><Neuronal Transmission><Neurons><Neuropeptides><Neurosciences><Neurotransmitters><Oral cavity><Output><Paralysis Agitans><Parkinson><Parkinson Disease><Pathway Analysis><Pattern><Pb element><Perception><Physiopathology><Play><Population Research><Population-based research><Population-level research><Preparation><Primary Parkinsonism><Primary Senile Degenerative Dementia><Process><Psyche structure><Reduced Glutathione><Reporter><Research><Risk Behaviors><Risky Behavior><Role><Schizophrenia><Schizophrenic Disorders><Seizure Disorder><Sensory Neurons><Specificity><Stimulus><Synapses><Synaptic><Techniques><Testing><Transgenic Animals><Visual Perception><Work><analog><at risk behavior><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><base><bases><behavior mechanism><behavioral control><behavioral disorder><body movement><caloric dietary content><causation><central nervous system plasticity><cnidocyte><connectome><connectome data><connectomic data><dementia praecox><diagnostic development><disease causation><epilepsia><epileptogenic><experiment><experimental research><experimental study><experiments><feeding><feeding-related behaviors><glia signaling><glial signaling><habituation><heavy metal Pb><heavy metal lead><hippocampal><imaging><investigate population><memory process><memory processing><mental><mental state><mental status><mouse model><murine model><nerve signaling><neural><neural circuit><neural circuitry><neural plasticity><neural signaling><neurocircuitry><neuronal><neuronal circuit><neuronal circuitry><neuronal signaling><neuroplastic><neuroplasticity><neurotransmission><novel><nutrient intake activity><pathophysiology><pharmacologic><population investigation><population level investigation><population specific research><preparations><primary degenerative dementia><programs><schizophrenic><senile dementia of the Alzheimer type><social role><studies of populations><study of the population><study population><survey population><synapse><synaptic circuit><synaptic circuitry><tool><two-photon>

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Arnaldo Carreira-Rosario

DUKE UNIVERSITY, DURHAM, NC

Exploratory lead · 30/100

Very recent

Active award

$199,319

FY 2026

Project Title

Structure and function of spontaneous network activity during circuit formation

Grant Number:

5R00NS119295-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2020

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Towards the end of nervous system development, neural circuits are extremely plastic. Small perturbations during this time can cause lifelong circuit and behavioral changes. Not surprisingly, mounting evidence suggests that several neurodevelopmental disorders, including autism spect...

Research Terms

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Clare Elizabeth Harrop

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 30/100

Very recent

Active award

$79,242

FY 2026

Project Title

Sex Informed Profiles of Eating Behaviors in Autism Across Childhood and Young Adulthood

Grant Number:

5R03MH136593-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Challenging or restrictive eating behaviors are well-documented in autistic individuals. Restrictive eating behaviors, such as food selectivity, refusal and neophobia occur at a greatly increased rate in autism. Eating disorders, such as anorexia nervosa, avoidant restrictive food in...

Research Terms

<0-11 years old><18 year old><18 years of age><21+ years old><4 year old><4 years of age><7 year old><7 years of age><ASD><Address><Adult><Adult Human><Age><Anorexia><Anorexia Nervosa><Area><Autism><Autism Diagnosis><Autistic Disorder><Behavior><Behavior Disorders><Behavioral><Binge eating disorder><Biological><Care Givers><Caregivers><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Chronology><Clinical><Data><Data Set><Development><Diagnosis><Differences between sexes><Differs between sexes><Early Infantile Autism><Eating><Eating Behavior><Eating Disorders><Exhibits><Female><Female Adolescents><Food><Food Intake><Funding><Goals><Hyperphagia><Individual><Infantile Autism><Kanner's Syndrome><Knowledge><Linear Regressions><Measures><Mental disorders><Mental health disorders><Modeling><NICHD><NIH><NIMH><National Institute of Child Health and Human Development><National Institute of Mental Health><National Institutes of Health><Nutritional><Oral><Outcome><Overeating><Patient Self-Report><Phenotype><Population><Predicting Risk><Psychiatric Disease><Psychiatric Disorder><Questionnaires><Research><Role><SAGA><SPT/ADA/Gcn5 Acetyltransferase><Sample Size><Sampling><Self-Report><Sensory><Sex Behavior><Sex Differences><Sex Disorders><Sex Ratio><Sexual Activity><Sexual Behavior><Sexual Dysfunction><Sexual differences><Texture><Time><United States National Institutes of Health><Variant><Variation><adolescent girl><adult with ASD><adult with autism><adult with autism spectrum disorder><adult youth><adulthood><adults on the autism spectrum><adults on the spectrum><age 18><age 18 years><age 4><age 4 years><age 7><age 7 years><age associated><age correlated><age dependent><age linked><age related><age specific><ages><autism spectral disorder><autism spectrum disorder><autistic><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><avoidant restrictive food intake disorder><behavior study><behavioral disorder><behavioral study><biologic><biological sex><biological sex as a modifier><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical significance><clinically significant><cohort><developmental><early childhood><eighteen year old><eighteen years of age><forecasting risk><four year old><four years of age><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><kids><life span><lifespan><male><mental illness><novel><nutritious><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><polyphagia><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><prospective test><psychiatric illness><psychological disorder><repetitive behavior><restrictive eating><risk prediction><risk predictions><seven year old><seven years of age><sex><sex activity><sex as a biological factor><sex as a biological measure><sex as a biological risk factor><sex as a biological variable><sex as a biological variance><sex as a biologically significant variable><sex as a fundamental variable><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><sexual activities><social><social role><trend><young adult><young adult age><young adulthood><youngster><♀><♂>

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GREGORY L WALLACE

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 30/100

Very recent

Active award

$79,242

FY 2026

Project Title

Sex Informed Profiles of Eating Behaviors in Autism Across Childhood and Young Adulthood

Grant Number:

5R03MH136593-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Challenging or restrictive eating behaviors are well-documented in autistic individuals. Restrictive eating behaviors, such as food selectivity, refusal and neophobia occur at a greatly increased rate in autism. Eating disorders, such as anorexia nervosa, avoidant restrictive food in...

Research Terms

<0-11 years old><18 year old><18 years of age><21+ years old><4 year old><4 years of age><7 year old><7 years of age><ASD><Address><Adult><Adult Human><Age><Anorexia><Anorexia Nervosa><Area><Autism><Autism Diagnosis><Autistic Disorder><Behavior><Behavior Disorders><Behavioral><Binge eating disorder><Biological><Care Givers><Caregivers><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Chronology><Clinical><Data><Data Set><Development><Diagnosis><Differences between sexes><Differs between sexes><Early Infantile Autism><Eating><Eating Behavior><Eating Disorders><Exhibits><Female><Female Adolescents><Food><Food Intake><Funding><Goals><Hyperphagia><Individual><Infantile Autism><Kanner's Syndrome><Knowledge><Linear Regressions><Measures><Mental disorders><Mental health disorders><Modeling><NICHD><NIH><NIMH><National Institute of Child Health and Human Development><National Institute of Mental Health><National Institutes of Health><Nutritional><Oral><Outcome><Overeating><Patient Self-Report><Phenotype><Population><Predicting Risk><Psychiatric Disease><Psychiatric Disorder><Questionnaires><Research><Role><SAGA><SPT/ADA/Gcn5 Acetyltransferase><Sample Size><Sampling><Self-Report><Sensory><Sex Behavior><Sex Differences><Sex Disorders><Sex Ratio><Sexual Activity><Sexual Behavior><Sexual Dysfunction><Sexual differences><Texture><Time><United States National Institutes of Health><Variant><Variation><adolescent girl><adult with ASD><adult with autism><adult with autism spectrum disorder><adult youth><adulthood><adults on the autism spectrum><adults on the spectrum><age 18><age 18 years><age 4><age 4 years><age 7><age 7 years><age associated><age correlated><age dependent><age linked><age related><age specific><ages><autism spectral disorder><autism spectrum disorder><autistic><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><avoidant restrictive food intake disorder><behavior study><behavioral disorder><behavioral study><biologic><biological sex><biological sex as a modifier><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical significance><clinically significant><cohort><developmental><early childhood><eighteen year old><eighteen years of age><forecasting risk><four year old><four years of age><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><kids><life span><lifespan><male><mental illness><novel><nutritious><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><polyphagia><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><prospective test><psychiatric illness><psychological disorder><repetitive behavior><restrictive eating><risk prediction><risk predictions><seven year old><seven years of age><sex><sex activity><sex as a biological factor><sex as a biological measure><sex as a biological risk factor><sex as a biological variable><sex as a biological variance><sex as a biologically significant variable><sex as a fundamental variable><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><sexual activities><social><social role><trend><young adult><young adult age><young adulthood><youngster><♀><♂>

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Jacob I Feldman

FATHER FLANAGAN'S BOYS' HOME, BOYS TOWN, NE

Exploratory lead · 22/100

Recent

Active award

$249,000

FY 2026

Project Title

Looking and Language (LoLa)

Grant Number:

4R00DC021501-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/5/2024

End Date:

2/28/2029

Project Abstract

Language outcomes are highly heterogenous in autism and can impact long-term psychosocial, educational, and vocational outcomes for children on the autism spectrum. Thus, there is a pressing need to identify novel approaches to language intervention, ideally those that can be implemented in early...

Research Terms

<0-11 years old><21+ years old><ASD><ASD community><Active Follow-up><Adolescent><Adolescent Youth><Adult><Adult Human><Advocate><Age><Attention><Auditory><Autism><Autistic Disorder><Award><Behavior><Brain><Brain Nervous System><Buccal Cavity><Buccal Cavity Head and Neck><Care Givers><Caregivers><Cavitas Oris><Child><Child Youth><Children (0-21)><Development><Developmental Disorder Speech or Language><Developmental Language Disorders><Diagnosis><Early Infantile Autism><Education><Educational aspects><Educational process of instructing><Encephalon><Evidence based intervention><Face><Foundations><Infant><Infantile Autism><Intervention><Kanner's Syndrome><Language><Language Development><Language Development Disorders><Language Disorders><Life><Linguistic><Linguistics><Mediating><Mouth><Oral cavity><Outcome><Outcome Study><Pattern><Phase><Randomized, Controlled Trials><Research><Scientist><Siblings><Source><Speech><Teaching><Testing><Training><Visual><Vocation><Work><acquiring language skills><active followup><adulthood><ages><audiovisual speech><auditory-visual speech><autism community><autism spectral disorder><autism spectrum disorder><autism spectrum disorder community><autistic><autistic children><autistic individuals><autistic people><autistic spectrum disorder><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><developmental><faces><facial><follow up><follow-up><followed up><followup><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><interest><intervention effect><juvenile><juvenile human><kids><language ability><language acquisition><language deficit><language learning><language outcome><language skills><member><new approaches><novel><novel approaches><novel strategies><novel strategy><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><preemptive intervention><psychosocial><randomized control trial><recruit><traditional therapy><treatment and outcome><word learning><youngster>

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Caroline M. Kelsey

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Exploratory lead · 22/100

Recent

Active award

$249,000

FY 2026

Project Title

Neural Markers of Developmental Delays in Premature and Full Term Infants

Grant Number:

4R00HD115830-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2029

Project Abstract

Project Summary/Abstract Premature infants are vulnerable to long-term social, cognitive, and behavioral difficulties. However, not all premature infants go on to have developmental delays. Moderate to late preterm infants (born after 32 weeks) represent a missed clinical population as they do not a...

Research Terms

<0-11 years old><4 year old><4 years of age><ASD><Active Follow-up><Age><Autism><Autism Diagnosis><Autistic Disorder><Award><Behavioral><Biological Markers><Blood Coagulation Factor I><Blood Coagulation Factor One><Blood Factor One><Blood flow><Brain><Brain Nervous System><Cerebrovascular Circulation><Child><Child Youth><Children (0-21)><Chronology><Clinic><Clinical><Coagulation Factor I><Coagulation Factor One><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Data><Development><Developmental Delay><Developmental Delay Disorders><Diagnosis><Disturbance in cognition><EEG><Early Infantile Autism><Early Intervention><Early identification><Electroencephalogram><Electroencephalography><Encephalon><Enrollment><Equilibrium><Factor I><Factor One><Faculty><Fibrinogen><Funding><Future><Gestation><Goals><Grant><Health><Health Care Facility><Health Facilities><Hemoglobin><Heterogeneity><Impaired cognition><Impairment><Infant><Infantile Autism><Interruption><Intervention Strategies><Investigation><Investigators><Kanner's Syndrome><Language><Learning><Life><Link><Measures><Mediating><Medical><Metabolic><Methods><Mission><Motor><NICHD><National Institute of Child Health and Human Development><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neurons><Nutrient><O element><O2 element><Oxygen><Participant><Pattern><Personal Satisfaction><Phase><Population><Position><Positioning Attribute><Pregnancy><Premature Birth><Premature Infant><Prematurely delivering><Preterm Birth><Primary Care><Process><Property><Public Health><Qualifying><Questionnaires><Research><Research Personnel><Researchers><Resolution><Rest><Sampling><Services><Social Development><Specific Child Development Disorders><Synaptic Potentials><Techniques><Testing><Theoretic Models><Theoretical model><Time><Training><United States><Visit><Vulnerable Populations><Well baby checks><Well baby checkups><Well baby visits><active followup><age 4><age 4 years><ages><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><balance><balance function><behavioral impairment><bio-markers><biologic marker><biomarker><blood flow in brain><brain blood circulation><brain blood flow><candidate biomarker><candidate marker><care facilities><cerebral blood flow><cerebral circulation><cerebrocirculation><cerebrovascular blood flow><cognitive development><cognitive dysfunction><cognitive loss><cost><developmental><developmental disease><developmental disorder><early childhood><enroll><experience><fNIRS><follow up><follow-up><followed up><followup><four year old><four years of age><frontal cortex><frontal lobe><functional near infrared spectroscopy><high risk><high risk infant><impaired behavior><improved><indexing><infant well check><infant well visits><infants born premature><infants born prematurely><intervention program><kids><life span><lifespan><multi-modality><multimodality><neural><neural imaging><neural mechanism><neuro-imaging><neuro-vascular><neuro-vascular coupling><neurodevelopment><neuroimaging><neurological imaging><neuromechanism><neuronal><neurovascular><neurovascular coupling><novel><postsynaptic><premature><premature baby><premature childbirth><premature delivery><premature infant human><prematurity><preterm baby><preterm delivery><preterm infant><preterm infant human><primary care clinic><primary care visit><programs><psychological outcomes><recruit><resolutions><response><response to therapy><response to treatment><screening program><social><synapse formation><synaptogenesis><temporal measurement><temporal resolution><therapeutic response><therapy response><time measurement><tool><treatment response><treatment responsiveness><vulnerable group><vulnerable individual><vulnerable infant><vulnerable people><well-being><wellbeing><youngster>

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Caroline Juliette Charpentier

UNIV OF MARYLAND, COLLEGE PARK, COLLEGE PARK, MD

Exploratory lead · 22/100

Recent

Active award

$248,998

FY 2026

Project Title

Neuro-computational mechanisms of social learning and variation along psychiatric symptom dimensions and in autism

Grant Number:

5R00MH123669-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

2/28/2027

Project Abstract

PROJECT SUMMARY Social learning is key for acquiring knowledge about the world and for deciding how to act in social situations. By allowing individuals to learn the consequences of actions in the environment without having to directly experience them, social learning abilities are evolutionary adva...

Research Terms

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MARJORIE SOLOMON

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Exploratory lead · 22/100

Recent

Active award

$242,362

FY 2026

Project Title

A pilot trial of the Individualized Placement and Support model in autistic adults in the community

Grant Number:

5R34MH138725-02

Activity Code:

R34

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2027

Project Abstract

ABSTRACT Over half a million autistic young adults will graduate from high school over the next ten years. As they enter early adulthood and no longer receive funded services through the education system, they will become increasingly disengaged from expected adult roles including getting and stayin...

Research Terms

<21 year old><21 years of age><21+ years old><ASD><Achievement><Achievement Attainment><Address><Adult><Adult Human><Advocate><Autism><Autistic Disorder><Autistic young adult><Benchmarking><Best Practice Analysis><California><Cell Communication and Signaling><Cell Signaling><Chronic><Client><Clinical Trials><Common Data Element><Communities><Development><Early Infantile Autism><Education><Educational aspects><Educational workshop><Effectiveness><Employment><Focus Groups><Funding><Goals><Grant><Hospitals><Hybrids><Infantile Autism><Informed Consent><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Intracellular Communication and Signaling><Job Satisfaction><Jobs><Kanner's Syndrome><Literature><Mediator><Mental Health><Mental Hygiene><Methods><Modeling><NIH><NIMH><National Institute of Mental Health><National Institutes of Health><Occupations><Outcome><Parents><Perception><Persons><Pilot Projects><Population><Process><Professional Positions><Provider><Psychological Health><QOL><Qualifying><Quality of life><Randomized><Role><Services><Signal Transduction><Signal Transduction Systems><Signaling><Strategic Planning><Supported Employment><System><Testing><Training><Underemployment><Unemployment><United States National Institutes of Health><Vocation><Waiting Lists><Work><Work Satisfaction><Workshop><acceptability and feasibility><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age 21><age 21 years><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic><autistic adult><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><benchmark><biological signal transduction><community academic collaboration><community academic partnership><community academic research partnership><community setting><community university partnership><developmental><disability><early adulthood><effectiveness trial><emerging adult><emotion regulation><emotional regulation><evidence base><experience><field based data><field learning><field study><field test><functional improvement><functional outcomes><high school><hybrid type 1 trial><hybrid type I trial><implementation science><improve function><improved><improved functional outcomes><indexing><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><innovate><innovation><innovative><intellectual and developmental disability><interest><jobless><joblessness><limited intellectual functioning><member><neuropsychiatric><neuropsychiatry><out of work><parent><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><person centered><physical conditioning><physical health><pilot study><pilot trial><programs><randomisation><randomization><randomized, clinical trials><randomly assigned><reading ability><reading achievement><reading competence><reading proficiency><scale up><skills><social cognition><social role><statistics><success><supportive employment><twenty-one year old><twenty-one years of age><underemployed><unemployed><waitlist><young adult with ASD><young adult with autism><young adult with autism spectrum disorder>

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Ahna Renee Skop

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 22/100

Recent

Active award

$233,250

FY 2026

Project Title

Characterization of midbody remnant mediated cell fate decisions in autism

Grant Number:

5R21MH138941-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

ABSTRACT Asymmetric division of neural progenitor cells (NPCs) is critical for the formation of the diverse cell types and complex architecture of the cerebral cortex. Abnormalities in this process have been consistently observed in autism spectrum disorder (ASD), manifesting as altered NPC prolife...

Research Terms

<21+ years old><3-D modeling><3D modeling><ASD><Abscission><Address><Adult><Adult Human><Affect><Architecture><Autism><Autistic Disorder><Automobile Driving><Belief><Brain><Brain Nervous System><Cell Body><Cell Growth in Number><Cell Line><Cell Multiplication><Cell Proliferation><Cell division><Cell surface><Cell to Cell Communication and Signaling><Cell-Cell Signaling><CellLine><Cells><Cellular Proliferation><Cerebral cortex><Characteristics><Complex><DNA mutation><Data><Development><Developmental Process><Dysfunction><Early Infantile Autism><Encephalon><Engineering / Architecture><Environment><Excision><Extirpation><Functional disorder><Gene Expression><Genetic><Genetic Change><Genetic Materials><Genetic defect><Genetic mutation><Goals><Grant><Human><Infantile Autism><Kanner's Syndrome><Knowledge><Label><Link><M Phase><MMAC1><MMAC1 protein><Mediating><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Messenger RNA><Mitosis><Mitosis Stage><Mitotic><Modeling><Modern Man><Molecular><Mutated in Multiple Advanced Cancers 1><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neural Stem Cell><Neurocyte><Neuronal Differentiation><Neurons><Organoids><Outcome><PHTS gene><PHTS protein><PTEN><PTEN gene><PTEN protein><PTEN1><Pathogenesis><Pathway interactions><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Physiopathology><Process><Proliferating><Proteome><Proteomics><Publishing><RNA Seq><RNA sequencing><RNAseq><Recurrence><Recurrent><Removal><Reporter><Research><Risk Factors><Risk-associated variant><Role><Series><Signal Pathway><Strains Cell Lines><Structure><Surface Proteins><Surgical Removal><System><Testing><Translating><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><cell type><cultured cell line><developmental><disease subgroups><disease subtype><disorder subtype><driving><experiment><experimental research><experimental study><experiments><extracellular vesicles><genetic information><genome mutation><iPS><iPSC><iPSCs><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><intercellular communication><loss of function mutation><mRNA><mosaic><mutated in multiple advanced cancers 1 protein><nerve stem cell><neural><neural control><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural regulation><neural stem and progenitor cells><neurodevelopment><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuromodulation><neuromodulatory><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><neuroregulation><novel><pathophysiology><pathway><phosphatase and tensin homologue on chromosome ten><progenitor and neural stem cells><progenitor cell division><progenitor cell proliferation><progenitor cell renewal><progenitor division><progenitor proliferation><progenitor renewal><resection><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><social role><stem and progenitor cell division><stem and progenitor cell proliferation><stem and progenitor cell renewal><stem cell division><stem cell proliferation><stem cell renewal><three-dimensional modeling><transcriptome sequencing><transcriptomic sequencing><uptake>

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Justin Wolter

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 22/100

Recent

Active award

$233,250

FY 2026

Project Title

Characterization of midbody remnant mediated cell fate decisions in autism

Grant Number:

5R21MH138941-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

ABSTRACT Asymmetric division of neural progenitor cells (NPCs) is critical for the formation of the diverse cell types and complex architecture of the cerebral cortex. Abnormalities in this process have been consistently observed in autism spectrum disorder (ASD), manifesting as altered NPC prolife...

Research Terms

<21+ years old><3-D modeling><3D modeling><ASD><Abscission><Address><Adult><Adult Human><Affect><Architecture><Autism><Autistic Disorder><Automobile Driving><Belief><Brain><Brain Nervous System><Cell Body><Cell Growth in Number><Cell Line><Cell Multiplication><Cell Proliferation><Cell division><Cell surface><Cell to Cell Communication and Signaling><Cell-Cell Signaling><CellLine><Cells><Cellular Proliferation><Cerebral cortex><Characteristics><Complex><DNA mutation><Data><Development><Developmental Process><Dysfunction><Early Infantile Autism><Encephalon><Engineering / Architecture><Environment><Excision><Extirpation><Functional disorder><Gene Expression><Genetic><Genetic Change><Genetic Materials><Genetic defect><Genetic mutation><Goals><Grant><Human><Infantile Autism><Kanner's Syndrome><Knowledge><Label><Link><M Phase><MMAC1><MMAC1 protein><Mediating><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Messenger RNA><Mitosis><Mitosis Stage><Mitotic><Modeling><Modern Man><Molecular><Mutated in Multiple Advanced Cancers 1><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neural Stem Cell><Neurocyte><Neuronal Differentiation><Neurons><Organoids><Outcome><PHTS gene><PHTS protein><PTEN><PTEN gene><PTEN protein><PTEN1><Pathogenesis><Pathway interactions><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Physiopathology><Process><Proliferating><Proteome><Proteomics><Publishing><RNA Seq><RNA sequencing><RNAseq><Recurrence><Recurrent><Removal><Reporter><Research><Risk Factors><Risk-associated variant><Role><Series><Signal Pathway><Strains Cell Lines><Structure><Surface Proteins><Surgical Removal><System><Testing><Translating><adulthood><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><cell type><cultured cell line><developmental><disease subgroups><disease subtype><disorder subtype><driving><experiment><experimental research><experimental study><experiments><extracellular vesicles><genetic information><genome mutation><iPS><iPSC><iPSCs><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><insight><intercellular communication><loss of function mutation><mRNA><mosaic><mutated in multiple advanced cancers 1 protein><nerve stem cell><neural><neural control><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural regulation><neural stem and progenitor cells><neurodevelopment><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuromodulation><neuromodulatory><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><neuroregulation><novel><pathophysiology><pathway><phosphatase and tensin homologue on chromosome ten><progenitor and neural stem cells><progenitor cell division><progenitor cell proliferation><progenitor cell renewal><progenitor division><progenitor proliferation><progenitor renewal><resection><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><social role><stem and progenitor cell division><stem and progenitor cell proliferation><stem and progenitor cell renewal><stem cell division><stem cell proliferation><stem cell renewal><three-dimensional modeling><transcriptome sequencing><transcriptomic sequencing><uptake>

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Winrich Freiwald

ROCKEFELLER UNIVERSITY, NEW YORK, NY

Exploratory lead · 22/100

Recent

Active award

$211,875

FY 2026

Project Title

Determining face representations within and transformations between temporal and prefrontal cortex

Grant Number:

5R21MH138848-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/12/2024

End Date:

11/30/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT Circuits of the visual system transform patterns of light impinging on the retina into an understanding of objects and their behavioral significance, achieving robustness and versatility currently not matched by even the most advanced computational vision models. Much of thi...

Research Terms

<2-photon><ASD><Address><Age><Agnosia for Faces><Anterior><Area><Autism><Autistic Disorder><Back><Behavioral><Biologic Models><Biological Models><Brain><Brain Nervous System><Brain region><Calcium><Callithrix><Categories><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Code><Coding System><Cognition><Cognitive><Communication><Data Set><Dimensions><Disease><Disorder><Dissection><Dorsum><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Etiology><Evaluation><Exhibits><FTD dementia><Face><Face Processing><Facial Recognition Agnosia><Failure><Feedback><Feeds><Frontal Temporal Dementia><Frontotemporal Dementia><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Goals><Hapale><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Infantile Autism><Information Retrieval><Information extraction><Intracellular Communication and Signaling><Investigation><Kanner's Syndrome><Lateral><Light><Lobe><Logic><Macaca><Macaque><Maps><Marmosets><Measures><Mission><Model System><Modeling><Modernization><Monkeys><NHP models><NIH><National Institutes of Health><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><New World Monkeys><Noise><Output><Pathway interactions><Pattern><Photoradiation><Physiopathology><Platyrrhina><Platyrrhini><Population><Prefrontal Cortex><Primates><Primates Mammals><Process><Prosopagnosia><Public Health><Recurrence><Recurrent><Research><Resolution><Retina><Role><Schizophrenia><Schizophrenic Disorders><Sensory Process><Shapes><Short-Tusked Marmoset><Sight><Signal Transduction><Signal Transduction Systems><Signaling><Social Functioning><Source><Stimulus><System><Techniques><Technology><Temporal Lobe><Testing><Time><Training><Unit of Measure><United States National Institutes of Health><Vision><Visual><Visual Cortex><Visual System><Work><ages><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><biological signal transduction><causation><cognitive function><dementia praecox><density><disability><disease causation><electrophysiological><extracellular><fMRI><face perception><faces><facial><facial processing><front temporal dementia><frontal lobe dementia><frontotemporal lobar degeneration dementia><frontotemporal lobar dementia><frontotemporal lobe degeneration associated with dementia><function socially><functioning social><gaze><imaging><insight><lobes><millimeter><multi-photon><neural><neural circuit><neural circuitry><neurocircuitry><neuronal><neuropsychiatric><neuropsychiatric disease><neuropsychiatric disorder><neuropsychiatry><nonhuman primate models><optic imaging><optical imaging><pathophysiology><pathway><physical property><platyrhine monkey><resolutions><response><schizophrenic><segregation><sex><social><social cognition><social role><spatial and temporal><spatial temporal><spatiotemporal><synaptic circuit><synaptic circuitry><temporal cortex><temporal measurement><temporal resolution><time measurement><two-photon><ventral pathway><ventral processing stream><ventral stream><ventral visual pathway><ventral visual processing stream><ventral visual stream><visual cortical><visual function><visual information><visual process><visual processing>

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Pumpki Lei Su

UNIVERSITY OF TEXAS DALLAS, RICHARDSON, TX

Exploratory lead · 22/100

Recent

Active award

$195,000

FY 2026

Project Title

Word Learning from Infant-Directed Speech in Autistic Children

Grant Number:

5R21DC021803-03

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2027

Project Abstract

PROJECT SUMMARY Caregivers frequently use infant-directed speech (IDS), commonly known as “parentese”, when speaking to young children. Compared to adult-directed speech (ADS), IDS is typically characterized by greater pitch variation, longer duration, and louder volume. IDS facilitates early langua...

Research Terms

<0-11 years old><2 year old><2 years of age><21+ years old><ASD><Acoustics><Adult><Adult Human><Affect><Age><Attention><Auditory><Autism><Autistic Disorder><Care Givers><Caregivers><Characteristics><Child><Child Youth><Children (0-21)><Clinical><Data><Diagnosis><Early Infantile Autism><Early Intervention><Educational process of instructing><Environment><Eye><Eyeball><Fostering><Future><Goals><Individual><Infant><Infantile Autism><Intervention><Kanner's Syndrome><Language><Language Development><Learning><Link><Loudness><Measures><Mission><Modeling><Motivation><NIDCD><NIH><National Institute on Deafness and Other Communication Disorders><National Institutes of Health><Outcome><Participant><Population><Process><QOL><Quality of life><Questionnaires><Research><Sensory><Social Environment><Social Interaction><Social outcome><Specific qualifier value><Specified><Speech><Stimulus><Teaching><Testing><Training><United States National Institutes of Health><Variant><Variation><Vocabulary><Vocabulary Words><Work><acquiring language skills><adulthood><age 2><age 2 years><aged 2 years><aged two years><ages><autism spectral disorder><autism spectrum disorder><autistic><autistic children><autistic spectrum disorder><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><classroom environment><college atmosphere><collegial atmosphere><collegiate atmosphere><education atmosphere><educational atmosphere><educational environment><gaze><improved><insight><intellectual atmosphere><interest><intervention program><kids><language ability><language acquisition><language learning><language outcome><language skills><learning atmosphere><learning environment><multi-modality><multimodality><novel><parenting education intervention><parenting education programs><parenting intervention><parenting program><parenting skill training><parenting training><peer><response><school atmosphere><school climate><social><social climate><social communication><social context><socioenvironment><socioenvironmental><training atmosphere><two year old><two years of age><university atmosphere><word learning><youngster>

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Mark J. Zylka

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 22/100

Recent

Active award

$194,375

FY 2026

Project Title

Luminescence-based biosensor to non-invasively measure UBE3A activity in the brain

Grant Number:

5R21NS142886-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/19/2025

End Date:

2/28/2027

Project Abstract

SUMMARY Genetic mutations that alter UBE3A ubiquitin ligase activity are linked to several neurodevelopmental disorders. Angelman syndrome (AS) is a severe syndromic neurodevelopmental disorder that is caused by deletion or loss- of-function (LOF) mutation of the maternally inherited copy of UBE3A. ...

Research Terms

<15q+ syndrome><20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><APF-1><ASD><ATP-Dependent Proteolysis Factor 1><Affect><Amino Acids><Angelman Syndrome><Animals><Assay><Attention><Autism><Autistic Disorder><Behavior><Beta Cadherin-Associated Protein><Beta-1 Catenin><Binding><Bioassay><Biological Assay><Biosensor><Blood Cells><Blood Sample><Blood specimen><Brain><Brain Nervous System><CUL-2><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Classification><Common Rat Strains><DNA mutation><Data><Development><Disease><Disorder><E3 Ligase><E3 Ubiquitin Ligase><E6AP><Early Infantile Autism><Encephalon><Engineering><Fibroblasts><Fireflies><Firefly Luciferases><Future><Gene Duplication><Genetic Change><Genetic defect><Genetic mutation><HMG-20><Happy Puppet Syndrome><Hereditary><High Mobility Protein 20><Human><In Vitro><Infantile Autism><Inherited><KI mice><Kanner's Syndrome><Knock-in Mouse><Lampyridae><Ligase><Ligase Gene><Link><Luciferase Immunologic><Luciferases><Macropain><Macroxyproteinase><Measures><Mediating><Mice><Mice Mammals><Missense Mutation><Modeling><Modern Man><Modification><Molecular><Molecular Interaction><Multicatalytic Proteinase><Murine><Mus><Mutation><N-terminal><NH2-terminal><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><PRO2286><Pathogenesis><Pathogenicity><Peptides><Peripheral Blood Cell><Phenotype><Photinus luciferin 4 monooxygenase><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteosome><Puppet Children><Rat><Rats Mammals><Rattus><Recombinants><Reporter><Reporting><Speed><Synthetases><Systematics><Testing><Therapeutic><Time><UBE3A><UBE3A gene><Ubiquitilation><Ubiquitin><Ubiquitin Ligase Component Gene><Ubiquitin Ligase Gene><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitin-Protein Ligase E3A><Ubiquitination><Ubiquitinoylation><Variant><Variation><aminoacid><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><beta cat><beta catenin><biological sensor><cell sorting><chromosome 15q duplication syndrome><chromosome 15q gain><chromosome 15q trisomy><determine efficacy><developmental><dup15q syndrome><duplication 15q syndrome><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><gain of function><gain of function mutation><genome mutation><human model><humanized mice><humanized mouse><improved><in vivo><innovate><innovation><innovative><knockin mice><loss of function><loss of function mutation><luminescence><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><model of human><mouse model><multicatalytic endopeptidase complex><murine model><neurodevelopmental disease><neuronal><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-human primate><non-invasive monitor><nonhuman primate><noninvasive monitor><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><partial trisomy 15q><pig model><piglet model><porcine model><promoter><promotor><puppetlike syndrome><swine model><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic development><trisomy 15q><ubiquination><ubiquitin conjugation><ubiquitin ligase><ubiquitin-protein ligase><unclassified variant><variant of uncertain clinical significance><variant of uncertain significance><variant of undetermined significance><variant of unknown significance><β-catenin>

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Matthew Daniel Lerner

DREXEL UNIVERSITY, PHILADELPHIA, PA

Exploratory lead · 22/100

Recent

Active award

$192,540

FY 2026

Project Title

Establishing Fidelity of Neurodiversity-Affirming Interventions

Grant Number:

5R21HD117690-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Project Abstract

Project Summary Interventions to support clinical and behavioral needs of autistic people are among the most resource- intensive in any field. While it is crucial to advance the use of empirically-supported interventions for this population, it is yet more pressing to understand factors that drive ...

Research Terms

<0-11 years old><21+ years old><ASD><ASD community><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Age><Autism><Autistic Disorder><Behavior><Behavioral><Care Givers><Caregivers><Child><Child Youth><Children (0-21)><Clinical><Code><Coding System><Communities><Consensus><Data><Decision Making><Development><Discipline><Domestic Horse><Early Infantile Autism><Elements><Ensure><Equine><Equine Species><Equus caballus><Equus przewalskii><Evidence based practice><Face><Family><Foundations><Future><Goals><Horses><Individual><Infantile Autism><Intervention><Interview><Kanner's Syndrome><Label><Language><Literature><Lived experience><Lived experiences><Maps><Measurement><Measures><Movement><Outcome><Parents><Population Intervention><Property><Psychometrics><Public Health><Research><Research Resources><Resources><Sampling><School-Age Population><Science><Services><Siblings><Structure><Survey Instrument><Surveys><Training><Variant><Variation><Work><Youth><Youth 10-21><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><ages><aspirate><autism community><autism spectral disorder><autism spectrum disorder><autism spectrum disorder community><autistic><autistic adolescent><autistic adult><autistic individuals><autistic people><autistic spectrum disorder><autistic youth><body movement><demographics><developmental><disability><evidence base><experience><faces><facial><implementation intervention><improved><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><informant><juvenile><juvenile human><kids><language ability><language skills><life span><lifespan><member><parent><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><population based intervention><population specific intervention><practice setting><school age><sound><stakeholder insights><stakeholder perspectives><tool><youngster><youth age><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder>

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Melanie Pellecchia

DREXEL UNIVERSITY, PHILADELPHIA, PA

Exploratory lead · 22/100

Recent

Active award

$192,540

FY 2026

Project Title

Establishing Fidelity of Neurodiversity-Affirming Interventions

Grant Number:

5R21HD117690-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Project Abstract

Project Summary Interventions to support clinical and behavioral needs of autistic people are among the most resource- intensive in any field. While it is crucial to advance the use of empirically-supported interventions for this population, it is yet more pressing to understand factors that drive ...

Research Terms

<0-11 years old><21+ years old><ASD><ASD community><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Age><Autism><Autistic Disorder><Behavior><Behavioral><Care Givers><Caregivers><Child><Child Youth><Children (0-21)><Clinical><Code><Coding System><Communities><Consensus><Data><Decision Making><Development><Discipline><Domestic Horse><Early Infantile Autism><Elements><Ensure><Equine><Equine Species><Equus caballus><Equus przewalskii><Evidence based practice><Face><Family><Foundations><Future><Goals><Horses><Individual><Infantile Autism><Intervention><Interview><Kanner's Syndrome><Label><Language><Literature><Lived experience><Lived experiences><Maps><Measurement><Measures><Movement><Outcome><Parents><Population Intervention><Property><Psychometrics><Public Health><Research><Research Resources><Resources><Sampling><School-Age Population><Science><Services><Siblings><Structure><Survey Instrument><Surveys><Training><Variant><Variation><Work><Youth><Youth 10-21><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><ages><aspirate><autism community><autism spectral disorder><autism spectrum disorder><autism spectrum disorder community><autistic><autistic adolescent><autistic adult><autistic individuals><autistic people><autistic spectrum disorder><autistic youth><body movement><demographics><developmental><disability><evidence base><experience><faces><facial><implementation intervention><improved><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><informant><juvenile><juvenile human><kids><language ability><language skills><life span><lifespan><member><parent><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><population based intervention><population specific intervention><practice setting><school age><sound><stakeholder insights><stakeholder perspectives><tool><youngster><youth age><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder>

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STEVEN W LEVISON

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

Exploratory lead · 22/100

Recent

Active award

$78,500

FY 2026

Project Title

Interleukin-6 induced synaptic dysgenesis in wild type vs. Shank3 mice

Grant Number:

5R03MH138839-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/11/2025

End Date:

2/28/2027

Project Abstract

ASD is a considered to be the result of complex interactions among genetic and environmental factors, suggesting that the rising incidence of ASD in the past decades can be largely attributed to environmental insults such as maternal infections. However, research using animal models for autism have ...

Research Terms

<22q13 deletion syndrome><ASD><ASD patient><Adolescent><Adolescent Youth><Adopted><Affect><Allergy><Ammon Horn><Animal Model><Animal Models and Related Studies><Anxiety><Astrocytes><Astrocytus><Astroglia><Attention><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Autoimmune Diseases><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Behavior><Behavioral><Blood Serum><Brain><Brain Nervous System><Causality><Cell Communication and Signaling><Cell Signaling><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><Complex><Cornu Ammonis><DNA mutation><Data><Disturbance in cognition><Dorsal><Early Infantile Autism><Encephalon><Environmental Factor><Environmental Risk Factor><Etiology><Gene Alteration><Gene Mutation><Gene x Environment Interaction><Genes><Genetic><Genetic Change><Genetic Models><Genetic defect><Genetic mutation><Gestation><Glutamate Receptor><Glutamates><Goals><Grooming><GxE interaction><HPGF><Hepatocyte-Stimulating Factor><Heterozygote><Hippocampus><Human><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immediate Memory><Immune><Immune Cell Activation><Immunes><Impaired cognition><Incidence><Individual><Infantile Autism><Infection><Inflammation><Inflammatory><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Interleukin-6><Intracellular Communication and Signaling><Investigators><KO mice><Kanner's Syndrome><Knock-out Mice><Knockout Mice><L-Glutamate><Link><MAST9><MGI-2><Measures><Memory><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutation><Myeloid Differentiation-Inducing Protein><Neonatal><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neural Transmission><Neurocyte><Neurons><Null Mouse><Paired-Associate Learning><Partner in relationship><Pathway interactions><Penetrance><Phelan-McDermid syndrome><Phenotype><Plasmacytoma Growth Factor><Play><Pollution><Prefrontal Cortex><Pregnancy><Proteins><Research><Research Personnel><Researchers><Risk><Self Assessment><Serum><Short-Term Memory><Signal Transduction><Signal Transduction Systems><Signaling><Social Interaction><Spinal Column><Spine><Synapses><Synaptic><Synaptic Transmission><TSP-1><TSP-2><TSP1><TSP2><Testing><Thrombospondin 1><Thrombospondin II><Ultrasonic><Ultrasonics><Vertebral column><Work><adult youth><astrocytic glia><autism model><autism spectral disorder><autism spectrum disorder><autistic individuals><autistic patient><autistic people><autistic spectrum disorder><autoimmune condition><autoimmune disorder><autoimmunity disease><backbone><behavior measurement><behavioral measure><behavioral measurement><biological signal transduction><causation><cognitive dysfunction><cognitive function><cognitive loss><compare to control><comparison control><critical period><cytokine><differential expression><differentially expressed><disease causation><environment effect on gene><environmental risk><epidemiology research study><epidemiology study><epidemiology survey><experience><experiment><experimental research><experimental study><experiments><frontal cortex><frontal lobe><gene defect><gene environment interaction><gene null><genome mutation><glutamatergic><heterozygosity><hevin><hippocampal><immune activation><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><inflammation in mothers><insight><intellectual and developmental disability><interferon beta 2><juvenile><juvenile human><limited intellectual functioning><male><mate><maternal inflammation><model of animal><model of autism spectrum disorder><mother inflammation><mouse model><murine model><mutant allele><neurodevelopment><neuronal><novel><null mutation><offspring><pathway><patient with ASD><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><pharmacologic><pregnant><preservation><repetitive behavior><response><social><spatial memory><stereotypy><synapse><synapse formation><synaptogenesis><therapeutic evaluation><therapeutic testing><thrombospondin 2><transcriptional differences><vocalization><working memory><young adult><young adult age><young adulthood><♂>

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Rebecca Schwarzlose

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 22/100

Recent

Active award

$6,162

FY 2026

Project Title

Neural mechanisms of sensory over-responsivity in children with and without ASD

Grant Number:

3R00HD109454-04S1

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2027

Project Abstract

PROJECT ABSTRACT Sensory over-responsivity (SOR), or strong negative reactions to and avoidance of innocuous sensory stimuli, affects about one in five school-age children and about two-thirds of children with autism spectrum disorder (ASD) and several other common neurodevelopmental disorders. Chil...

Research Terms

<0-11 years old><ASD><Affect><Anxiety><Anxiety Disorders><Area><Attenuated><Auditory><Auditory Cortex><Auditory area><Autism><Autistic Disorder><Award><Basic Research><Basic Science><Brain><Brain Nervous System><Causality><Cell Communication and Signaling><Cell Signaling><Child><Child Youth><Childhood><Children (0-21)><Clinical><Committee Members><Communities><Data><Data Set><Development><Diagnosis><Distress><Early Infantile Autism><Encephalon><Etiology><Event><Exhibits><Family><Fear><Fright><Functional MRI><Functional Magnetic Resonance Imaging><Functional impairment><Future><Goals><Health><Impairment><Infantile Autism><Institution><Intervention><Intracellular Communication and Signaling><Investigators><Kanner's Syndrome><Knowledge><Learning><Location><Measurable><Measurement><Measures><Mental disorders><Mental health disorders><Mentors><Neurodevelopmental Disorder><Neurological Development Disorder><Neurosciences Research><Noise><Nutrition><Pathway interactions><Personal Satisfaction><Phase><Prevalence><Psychiatric Disease><Psychiatric Disorder><Psychopathology><Reaction><Research><Research Personnel><Researchers><Rest><Risk><Running><Scanning><School-Age Population><Scientific Advances and Accomplishments><Scientist><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Site><Social isolation><Standardization><Stimulus><Symptoms><Tactile><Techniques><Testing><Training><Work><abnormal psychology><attenuate><attenuates><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic children><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><base><bases><biological signal transduction><career><causation><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><complex data><cost><developmental><disease causation><effective intervention><experience><fMRI><fMRI scan><functional MRI scan><functional magnetic resonance imaging scan><improved><innovate><innovation><innovative><insight><kids><mental illness><methods to study multiple-level influences><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><neural><neural adaptation><neural correlate><neural mechanism><neuroadaptation><neurodevelopmental disease><neuromechanism><new approaches><novel><novel approaches><novel strategies><novel strategy><pathway><pediatric><peer><perceptual stimulus><physicochemical phenomena related to the senses><poor sleep><psychiatric illness><psychological disorder><recruit><response><school age><scientific accomplishments><scientific advances><sensory mechanism><sensory neuroscience><sensory stimulus><skills><social><success><tool><translation strategy><translational approach><translational strategy><well-being><wellbeing><youngster>

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Simon Chamberland

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 16/100

Active award

$249,000

FY 2026

Project Title

Synaptic and cellular mechanisms of neuronal synchronization

Grant Number:

5R00MH126157-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

1/31/2027

Project Abstract

Project Summary/Abstract Neuronal activity must be precisely coordinated to provide an accurate representation of our environment, a feature exemplified by the electrical patterns measured in the brain during spatial navigation and memory retrieval. While the activity of individual neurons is tuned ...

Research Terms

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Jean-Paul Noel

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 16/100

Active award

$249,000

FY 2026

Project Title

Neural and Computational Architecture for Complex Navigation and Subjective Self-Location

Grant Number:

5R00NS128075-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

11/30/2027

Project Abstract

Project Summary Candidate and Career Goals: I intend to become an independent scientist at a research-first academic institution, bridging across levels of description (i.e., from computations to neurons) and furthering our understanding of how the brain infers the world around us, as well as oursel...

Research Terms

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Jacqueline Giovanniello

TEMPLE UNIV OF THE COMMONWEALTH, PHILADELPHIA, PA

Exploratory lead · 16/100

Active award

$245,650

FY 2026

Project Title

Revealing the neural mechanisms of amygdala-striatal control of stress-induced habits

Grant Number:

5R00MH135177-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2027

Project Abstract

PROJECT SUMMARY: Updates: I am moving to a new position at Temple University Lewis Katz School of Medicine as an independent, tenure-track Assistant Professor in the Department of Neural Science. Here, I will conduct the R00 phase experiments and develop my own independent research program. The ove...

Research Terms

<16p11.2><ASD><ASD patient><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Animals><Autism><Autism Spectrum Disorder patient><Autistic Disorder><Behavior><Behavior Conditioning Therapy><Behavior Control><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Manipulation><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Brain><Brain Nervous System><Calcium><Cell Body><Cells><Characteristics><Chromosomal microdeletion><Chronic stress><Conditioning Therapy><Corpus Striatum><Corpus striatum structure><D1 receptor><DNA Alteration><DNA Sequence Alteration><Data><Data Analyses><Data Analysis><Decision Making><Doctor of Philosophy><Dopamine D1 Receptor><Dorsal><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Encephalon><Environment><Environmental Factor><Environmental Risk Factor><Equilibrium><Evaluation><Exposure to><Foundations><Funding><Future><Gene x Environment Interaction><Genes><Genetic><Genetic Alteration><Goals><GxE interaction><Habits><Human><Image><In vivo two-photon calcium imaging><Infantile Autism><Kanner's Syndrome><Knowledge><Learning><Measures><Mentors><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Outcome><Pathologic><Ph.D.><PhD><Phase><Population><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Predisposition><Research><Research Associate><Resolution><Rewards><Rodent><Rodentia><Rodents Mammals><Role><Science><Sequence Alteration><Slice><Stress><Striate Body><Striatum><Susceptibility><Synapses><Synaptic><System><Technical Expertise><Testing><Therapeutic><Training><Universities><Update><Work><amygdaloid nuclear complex><autism model><autism spectral disorder><autism spectrum disorder><autistic patient><autistic spectrum disorder><balance><balance function><behavior intervention><behavior phenotype><behavioral control><behavioral intervention><behavioral phenotyping><cell type><data interpretation><electrophysiological><endophenotype><environment effect on gene><environmental risk><experiment><experimental research><experimental study><experiments><gene environment interaction><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><genomic alteration><imaging><imaging approach><imaging based approach><improved><in vivo><in vivo calcium imaging><insight><learning outcome><maladaptive behavior><medical college><medical schools><microdeletion><model of autism spectrum disorder><mouse model><murine model><neural><neural mechanism><neuromechanism><neuronal><patient with ASD><post-doc><post-doctoral><post-doctoral trainee><premature><prematurity><professor><programs><prospective><research associates><resolutions><response><school of medicine><skills><social role><stress reduction><striatal><synapse><synergism><technical skills><tenure process><tenure track>

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GEOFFREY J GOODHILL

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 16/100

Active award

$235,342

FY 2026

Project Title

Identifying autism motor deficits in infants using computer vision

Grant Number:

5R21MH136592-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/11/2024

End Date:

11/30/2026

Project Abstract

ABSTRACT Recent work suggests that motor differences in infancy can predict subsequent ASD diagnosis, with the promise of earlier identification of ASD, and faster referral to early intervention than is currently possible. However objectively quantifying these differences has proved challenging. Her...

Research Terms

<0-11 years old><12 year old><12 years of age><6 year old><6 years of age><ASD><Address><Algorithms><Autism><Autism Diagnosis><Autistic Disorder><Behavior><Behavior assessment><Behavioral><Biological Markers><Body part><Brain imaging><Child><Child Youth><Childhood ALL><Childhood Acute Lymphoblastic Leukemia><Childhood Acute Lymphocytic Leukemia><Childhood Acute Lymphogenous Leukemia><Childhood Acute Lymphoid Leukemia><Children (0-21)><Clinical><Clinical assessments><Code><Coding System><Computational Technique><Computational toolkit><Computer Vision Systems><Computer software><Data><Data Set><Development><Diagnosis><Diagnostic><Dictionary><Dimensions><Early Diagnosis><Early Infantile Autism><Early Intervention><Early identification><Ethology><Exhibits><Family Medical History><Family Medical History Epidemiology><Family history of><Future><Goals><Grain><Human><Impairment><Infant><Infantile Autism><Investigators><Joints><Kanner's Syndrome><Knowledge><L1 Lymphocytic Leukemia><Location><Lymphoblastic Leukemia, Acute, L1><Machine Learning><Methods><Modern Man><Motor><Movement><Pattern><Pediatric ALL><Pediatric Acute Lymphoblastic Leukemia><Pediatric Acute Lymphocytic Leukemia><Pediatric Acute Lymphogenous Leukemia><Pediatric Acute Lymphoid Leukemia><Phenotype><Prospective Studies><Research Personnel><Researchers><Resolution><Sampling><Scientist><Severities><Siblings><Site><Software><Structure><Techniques><Variant><Variation><Work><age 12><age 12 years><age 6><age 6 years><associated symptom><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><auto-segmentation><automated segmentation><automatic segmentation><autosegmentation><behavior study><behavioral assessment><behavioral study><bio-markers><biologic marker><biomarker><body movement><brain visualization><co-morbid symptom><co-occuring symptom><cognitive development><comorbid symptom><computational toolbox><computational tools><computational toolset><computer vision><computerized tools><concurrent symptom><cooccuring symptom><data collection site><deep learning><deep learning method><deep learning strategy><developmental><diagnostic tool><early detection><image processing><imaging study><improved><infancy><infant ALL><infantile><kids><kinematic model><kinematics><machine based learning><motor behavior><motor deficit><motor impairment><movement impairment><movement limitation><open source><prospective research study><prospective survey><resolutions><screening><screenings><six year old><six years of age><social><symptom association><symptom comorbidity><tool><twelve year old><twelve years of age><unsupervised learning><unsupervised machine learning><youngster>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Natasha Marrus

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 16/100

Active award

$235,342

FY 2026

Project Title

Identifying autism motor deficits in infants using computer vision

Grant Number:

5R21MH136592-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/11/2024

End Date:

11/30/2026

Project Abstract

ABSTRACT Recent work suggests that motor differences in infancy can predict subsequent ASD diagnosis, with the promise of earlier identification of ASD, and faster referral to early intervention than is currently possible. However objectively quantifying these differences has proved challenging. Her...

Research Terms

<0-11 years old><12 year old><12 years of age><6 year old><6 years of age><ASD><Address><Algorithms><Autism><Autism Diagnosis><Autistic Disorder><Behavior><Behavior assessment><Behavioral><Biological Markers><Body part><Brain imaging><Child><Child Youth><Childhood ALL><Childhood Acute Lymphoblastic Leukemia><Childhood Acute Lymphocytic Leukemia><Childhood Acute Lymphogenous Leukemia><Childhood Acute Lymphoid Leukemia><Children (0-21)><Clinical><Clinical assessments><Code><Coding System><Computational Technique><Computational toolkit><Computer Vision Systems><Computer software><Data><Data Set><Development><Diagnosis><Diagnostic><Dictionary><Dimensions><Early Diagnosis><Early Infantile Autism><Early Intervention><Early identification><Ethology><Exhibits><Family Medical History><Family Medical History Epidemiology><Family history of><Future><Goals><Grain><Human><Impairment><Infant><Infantile Autism><Investigators><Joints><Kanner's Syndrome><Knowledge><L1 Lymphocytic Leukemia><Location><Lymphoblastic Leukemia, Acute, L1><Machine Learning><Methods><Modern Man><Motor><Movement><Pattern><Pediatric ALL><Pediatric Acute Lymphoblastic Leukemia><Pediatric Acute Lymphocytic Leukemia><Pediatric Acute Lymphogenous Leukemia><Pediatric Acute Lymphoid Leukemia><Phenotype><Prospective Studies><Research Personnel><Researchers><Resolution><Sampling><Scientist><Severities><Siblings><Site><Software><Structure><Techniques><Variant><Variation><Work><age 12><age 12 years><age 6><age 6 years><associated symptom><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><auto-segmentation><automated segmentation><automatic segmentation><autosegmentation><behavior study><behavioral assessment><behavioral study><bio-markers><biologic marker><biomarker><body movement><brain visualization><co-morbid symptom><co-occuring symptom><cognitive development><comorbid symptom><computational toolbox><computational tools><computational toolset><computer vision><computerized tools><concurrent symptom><cooccuring symptom><data collection site><deep learning><deep learning method><deep learning strategy><developmental><diagnostic tool><early detection><image processing><imaging study><improved><infancy><infant ALL><infantile><kids><kinematic model><kinematics><machine based learning><motor behavior><motor deficit><motor impairment><movement impairment><movement limitation><open source><prospective research study><prospective survey><resolutions><screening><screenings><six year old><six years of age><social><symptom association><symptom comorbidity><tool><twelve year old><twelve years of age><unsupervised learning><unsupervised machine learning><youngster>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Elena Jean Tenenbaum

DUKE UNIVERSITY, DURHAM, NC

Exploratory lead · 16/100

Active award

$201,250

FY 2026

Project Title

Examining precursors to language impairment in ASD via remote assessment

Grant Number:

5R21DC022378-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2027

Project Abstract

Project Summary/Abstract Roughly 30% of autistic individuals remain minimally verbal as adults, often despite significant intervention. This is due, in part, to our limited understanding of the mechanisms underlying language development in autistic children. This gap in our knowledge is attributable...

Research Terms

<0-11 years old><21+ years old><3 year old><3 years of age><ASD><Acoustics><Adult><Adult Human><Autism><Autism Diagnosis><Autistic Disorder><Behavior><Child><Child Youth><Children (0-21)><Clinical><Code><Coding System><Cognitive><Computer Vision Systems><Computer software><Computers><Data><Development><Diagnosis><Early Diagnosis><Early Infantile Autism><Enrollment><Evidence based intervention><Family><Future><Goals><Grant><Heterogeneity><Home><Impairment><Individual><Infant><Infantile Autism><Intervention><Investigation><Investigators><Kanner's Syndrome><Knowledge><Laboratories><Language><Language Development><Language Disorders><Learning><Link><Measures><NIDCD><National Institute on Deafness and Other Communication Disorders><Outcome><Parents><Pattern><Performance><Persons><Population><Process><Prospective Studies><Psychologist><QOL><QOL improvement><Quality of life><Reporting><Research><Research Personnel><Researchers><Sample Size><Sampling><Services><Siblings><Software><Speech><Speech Perception><Speech Sound><Testing><Time><Training><Visit><Work><acquiring language skills><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age 3><age 3 years><autism spectral disorder><autism spectrum disorder><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><career><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical diagnosis><cognitive ability><cognitive development><cognitive task><computer vision><design><designing><developmental><early detection><enroll><experiment><experimental research><experimental study><experiments><gaze><homes><improved><improvements in QOL><improvements in quality of life><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><infancy><infantile><kids><language ability><language acquisition><language deficit><language impairment><language learning><language onset><language outcome><language skills><minimally speaking><minimally verbal><parent><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><precision medicine><precision-based medicine><prospective research study><prospective survey><quality of life improvement><remote administration><remote assessment><remote evaluation><response><skills><sound><speech processing><success><three year old><three years of age><youngster>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ramendra N Saha

UNIVERSITY OF CALIFORNIA, MERCED, MERCED, CA

Exploratory lead · 16/100

Active award

$198,125

FY 2026

Project Title

The BAF chromatin remodeling complex in experience-induced neuronal gene transcription and synapse maturation; implications for autism spectrum disorders

Grant Number:

5R21MH139062-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY Neurodevelopmental disorders (NDDs), especially autism spectrum disorders (ASD), are alarmingly prevalent among our children. Recent genome-wide studies suggest a strong correlation between ASD and loss-of-function mutations in genes encoding subunits of a particular chromatin remode...

Research Terms

<0-11 years old><170-kD Gene BRG1-Associated Factor><ARID1A><ARID1A gene><ASD><AT- rich interactive domain-containing protein 1A><AT-rich interactive domain 1A gene><Assay><Attenuated><Autism><Autistic Disorder><Automobile Driving><BAF170 Gene><BBB crossing><Basic Research><Basic Science><Bioassay><Biological><Biological Assay><Biological Function><Biological Process><Biology><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><CRACC2 Gene><Cancers><Candidate Disease Gene><Candidate Gene><Cell Communication and Signaling><Cell Signaling><Cellular Assay><Cellular biology><Child><Child Youth><Children (0-21)><Chromatin><Chromatin Remodeling Complex><Chromatin Remodeling Complex BAF170 Subunit Gene><Chromatin Remodeling Factor><Coffin-Siris Syndrome><Combinatorics><Common Rat Strains><Complex><DNA Molecular Biology><DNA Replication><DNA Synthesis><DNA biosynthesis><DNA mutation><DNA-Dependent RNA Polymerase II><Data><Development><Disease><Disorder><Dissociation><Dose><Early Gene Transcriptions><Early Infantile Autism><Electrodes><Encephalon><Encephalon Diseases><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Funding Opportunities><Future><Gene Expression><Gene Transcription><Genes><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Human><Immediate-Early Genes><Impairment><In Vitro><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Intrinsic factor><Kanner's Syndrome><Knowledge><L-Proline><Letters><Light><Liquid substance><Malignant Neoplasms><Malignant Tumor><Mammalian Chromatin Remodeling Complex, BRG1-Associated Factor 170 Gene><Mediating><Meta-Analysis><Modern Man><Molecular><Molecular Biology><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Mutate><Mutation><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocyte><Neurodevelopmental Disorder><Neurological Development Disorder><Neurons><Non-Polyadenylated RNA><Nuclear><Outcome><Penetrance><Phase><Photoradiation><Post-Transcriptional Gene Silencing><Process><Productivity><Proline><Proline-Rich Domain><Proline-Rich Region><Protein Subunits><Proteins><RNA><RNA Expression><RNA Gene Products><RNA Interference><RNA Polymerase B><RNA Polymerase II><RNA Silencing><RNAi><Rat><Rats Mammals><Rattus><Ribonucleic Acid><Risk Factors><Role><Route><SMARCA2><SMARCA2 gene><SMARCC2><SMARCC2 gene><SWI/SNF Complex 170 kDa Subunit Gene><SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily C, Member 2 Gene><SWI3-Like Protein Gene><Saccharose><Sequence-Specific Posttranscriptional Gene Silencing><Signal Transduction><Signal Transduction Systems><Signaling><Structure><Sucrose><Synapses><Synaptic><Syndrome><Testing><Therapeutic><Therapeutic Intervention><Topoisomerase Inhibitors><Transcript><Transcription><United States National Institutes of Health><attenuate><attenuates><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><biologic><biological signal transduction><blood-brain barrier crossing><bloodbrain barrier crossing><brahma><brahma gene product><brahma protein><brm gene product><cell assay><cell biology><chromatin modifier><chromatin remodeling><conformation><conformational><conformational state><conformationally><conformations><dark matter><design><designing><developmental><driving><dwarfism-onychodysplasia syndrome><epigenetically><exome sequencing><exome-seq><experience><fifth digit syndrome><flexibility><flexible><fluid><functional loss><fused in sarcoma><genome mutation><genome scale><genome wide analysis><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><human disease><in vivo><inhibitor><insight><intellectual and developmental disability><interest><intervention therapy><kids><knock-down><knockdown><limited intellectual functioning><liquid><loss of function mutation><malignancy><member><neoplasm/cancer><neurodevelopment><neurodevelopmental disease><neuronal><novel><pharmacologic><postmitotic><predictive tools><recruit><repair><repaired><response><social role><synapse><synapse function><synaptic function><therapeutic agent development><therapeutic development><youngster>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Teresa Marie Girolamo

SAN DIEGO STATE UNIVERSITY, SAN DIEGO, CA

Exploratory lead · 16/100

Active award

$194,597

FY 2026

Project Title

Quantifying communicative feedback in racially and ethnically diverse autistic adolescents who are minimally verbal or have language impairment

Grant Number:

5R21DC021769-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2027

Project Abstract

Language in autism is heterogeneous. Thirty percent of autistic individuals use significantly fewer spoken words than expected levels relative to age (i.e., are minimally verbal [MV-ASD]) past age 5, and more than 50% have significant challenges with structural language, or language impairment (ALI)...

Research Terms

<0-11 years old><12-20 years old><13 year old><13 years of age><21+ years old><5 year old><5 years of age><ASD><Access to Care><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Age><Agreement><Application Context><Area><Autism><Autism Diagnosis><Autistic Disorder><Behavior assessment><Benchmarking><Best Practice Analysis><Care Givers><Caregivers><Cell Communication and Signaling><Cell Signaling><Child><Child Youth><Children (0-21)><Classification><Clinical><Code><Coding System><Communication><Communication Disorders><Communication impairment><Communicative Disorders><Communities><Comprehension><Confidence Intervals><Delphi Study><Development><Early Infantile Autism><Environment><Failure><Feedback><Future><Goals><Health Services Accessibility><Heterogeneity><Individual><Individuals from minority><Individuals of minority><Infantile Autism><Intervention><Intracellular Communication and Signaling><Kanner's Syndrome><Knowledge><Language><Language Development><Life><Linguistic><Linguistics><Measurement><Measures><Mediating><Minority Groups><Minority People><Minority Population><Minority Recruitment><Minority individual><Mission><NIDCD><NIH><National Institute on Deafness and Other Communication Disorders><National Institutes of Health><Needs Assessment><On-Line Systems><Online Systems><Outcome><Partner Communications><Perception><Persons><Prevalence><Property><Public Health><Reporting><Research><Research Resources><Resources><Role><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Stimulus><Systematics><Time><United States National Institutes of Health><Work><Youth><Youth 10-21><access to health services><access to services><access to treatment><accessibility to health services><acquiring language skills><adolescence (12-20)><adolescent minority><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><adulthood><adulthood transition><age 13><age 13 years><age 5><age 5 years><ages><autism spectral disorder><autism spectrum disorder><autistic><autistic adolescent><autistic individuals><autistic people><autistic spectrum disorder><autistic youth><availability of services><behavior test><behavioral assessment><behavioral test><benchmark><biological signal transduction><care access><community based participatory approach><community based participatory design><community based participatory method><community based participatory process><community participatory approach><community participatory design><community participatory method><community participatory model><contextual factors><design><designing><developmental><disparities in race><disparity due to race><early adulthood><emerging adult><ethnic diversity><ethnic minority><ethnically diverse><experience><five year old><five years of age><health equity promotion><health service access><health services availability><improved><improved outcome><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><inequality due to race><inequity due to race><interest><juvenile><juvenile human><kids><language ability><language acquisition><language impairment><language learning><language skills><minimally speaking><minimally verbal><minority children><minority health><minority youth><natural language><online computer><outcome prediction><pediatric minority><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><poor health outcome><promote health equity><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial disparity><racial diversity><racial inequality><racial inequity><racial minority><racially diverse><racially unequal><recruit><recruiting minorities><reduced health outcome><remote assessment><remote evaluation><satisfaction><service availability><social role><standard measure><success><thirteen year old><thirteen years of age><tool><transition from adolescence to adulthood><transition into adulthood><transition to adulthood><translational study><treatment access><under served community><underserved community><web based><worse health outcome><young minority><youngster><youth age><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder>

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