CAROL A. DERBY

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

High-opportunity lead · 88/100

Likely hiring

Large award

Very recent

Active award

$6,296,132

FY 2026

Project Title

Einstein Aging Study

Grant Number:

5P01AG003949-41

Activity Code:

P01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/29/1982

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT The etiology of Alzheimer’s disease and related dementias (ADRD) is multifactorial and given the current lack of disease-modifying treatments, there is a growing need to better understand the roles of modifiable risk factors. The overarching goal of this Einstein Aging Study Program Project...

Research Terms

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JILL M DANIEL

TULANE UNIVERSITY OF LOUISIANA, NEW ORLEANS, LA

High-opportunity lead · 88/100

Likely hiring

Large award

Very recent

Active award

$2,799,973

FY 2026

Project Title

Estrogens, Cardiometabolic Health, and Female Cognitive Aging

Grant Number:

5P01AG071746-05

Activity Code:

P01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Overall Summary Loss of ovarian function at menopause is hypothesized to be a risk factor for Alzheimer’s disease and related dementias. Research in preclinical models indicates that estrogens are neuroprotective and can positively impact the cognitive aging trajectory. However, clinical data have b...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><APF-1><ATP-Dependent Proteolysis Factor 1><Adult-Onset Diabetes Mellitus><Affect><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Ammon Horn><Aquadiol><Arteriosclerotic Dementia><Autoregulation><Behavior><Blood Vessels><Brain><Brain Nervous System><CTX><CYCLO-cell><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Carloxan><Ciclofosfamida><Ciclofosfamide><Cicloxal><Clafen><Claphene><Clinical Data><Cognition><Cognition Disorders><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Cycloblastin><Cycloblastine><Cyclophospham><Cyclophosphamide><Cyclophosphamidum><Cyclophosphan><Cyclophosphane><Cyclophosphanum><Cyclostin><Cyclostine><Cytophosphan><Cytophosphane><Cytoxan><Development><Diet><Dimenformon><Diogyn><Diogynets><Disease><Disorder><Disturbance in cognition><Dysfunction><ENOS><ERalpha><ERα><ESR1><ESR1 gene><Encephalon><Endocrine Gland Secretion><Endocrine Therapy><Endothelial Nitric Oxide Synthase><Endoxan><Endoxana><Enduxan><Ensure><Estrace><Estradiol><Estradiol Receptor alpha><Estradiol Receptor α><Estradiol-17 beta><Estradiol-17beta><Estraldine><Estrogen Receptor 1><Estrogen Receptor alpha><Estrogen Receptor α><Estrogen Receptors><Estrogen Therapy><Estrogens><Female><Fosfaseron><Functional disorder><Genoxal><Genuxal><Goals><HMG-20><Health><Health Status><Heart Vascular><High Fat Diet><High Mobility Protein 20><Hippocampus><Homeostasis><Hormonal Therapy><Hormones><Hypertension><Impaired cognition><Impairment><Incidence><Insulin Resistance><Investigation><Ketosis-Resistant Diabetes Mellitus><Leadership><Ledoxina><Level of Health><Long-Term Potentiation><Macropain><Macroxyproteinase><Maturity-Onset Diabetes Mellitus><Measurement><Memory><Menopause><Metabolic><Metabolic syndrome><Mitoxan><Modeling><Molecular><Multicatalytic Proteinase><NIDDM><NOS3><NOS3 gene><NR3A1><Neosar><Nerve Degeneration><Neuron Degeneration><Nitric Oxide Synthase 3><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Ovarian><Ovocyclin><Ovocylin><P01 Mechanism><P01 Program><Personalized medical approach><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Pre-Clinical Model><Preclinical Models><Primary Senile Degenerative Dementia><Procedures><Process><Procytox><Program Project Grant><Program Research Project Grants><Progynon><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteosome><Recommendation><Regulation><Reproducibility of Findings><Reproducibility of Results><Research><Research Program Projects><Risk Factors><Rodent Model><Sendoxan><Signal Pathway><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Syklofosfamid><Synaptic plasticity><System><T2 DM><T2D><T2DM><Testing><Therapeutic Estradiol><Therapeutic Estrogen><Therapeutic Hormone><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Type III nitric oxide synthase><Ubiquitin><Variant><Variation><Vascular Dementia><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Weight Gain><Weight Increase><Woman><Zytoxan><adult onset diabetes><aged brain><aging brain><aging delay><alzheimer risk><attenuate aging><blood glucose regulation><body weight gain><body weight increase><cardiometabolic><cardiometabolism><cardiovascular disorder><cerebrovascular contributions to dementia><circulatory system><cognitive change><cognitive disease><cognitive disorder><cognitive dysfunction><cognitive function><cognitive loss><cognitive syndrome><decelerate aging><delay age related><design><designing><developmental><diets><estrogen hormone therapy><estrogen treatment><experiment><experimental research><experimental study><experiments><glucose control><glucose homeostasis><glucose regulation><health level><high blood pressure><hippocampal><hormone therapy><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><individualized approach><insulin resistant><insulin tolerance><ketosis resistant diabetes><maturity onset diabetes><menopausal hormone therapy><menopausal hormone treatment><mid life><mid-life><middle age><middle aged><midlife><midlife estradiol><multicatalytic endopeptidase complex><neural degeneration><neuro-vascular coupling><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><neuroprotection><neuroprotective><neurovascular coupling><pathophysiology><pause aging><personalized approach><postpone age related><precision approach><preservation><primary degenerative dementia><programs><response><retards aging><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><slow aging><slow down aging><slow the rate of aging><tailored approach><treated with estrogen><treatment with estrogen><type 2 DM><type II DM><type two diabetes><vascular><vascular contributions in dementia><vascular contributions to dementia><vascular related dementia><wt gain><♀>

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JANKO Z. NIKOLICH

UNIVERSITY OF ARIZONA, TUCSON, AZ

High-opportunity lead · 80/100

Likely hiring

Large award

Recent

Active award

$2,596,721

FY 2026

Project Title

Thymic and Peripheral Aspects of T Cell Aging and Rejuvenation

Grant Number:

5P01AG052359-09

Activity Code:

P01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2017

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

OVERALL- Abstract Infectious disease, cancer, and autoimmune disorders affect hundreds of millions of older adults. They reduce length and quality of life across the globe and inflict a massive economic burden on society, as vividly exemplified by the SARS-CoV-2 pandemic, that has claimed 93.1% of ...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Address><Affect><Age><Aging><Archives><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Bone Marrow><Bone Marrow Reticuloendothelial System><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 virus><COVID-19 years><COVID19 virus><Cancers><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Count><Cell Function><Cell Growth and Maintenance><Cell Maintenance><Cell Number><Cell Physiology><Cell Process><Cell Senescence><Cell Signaling><Cell Survival><Cell Viability><Cells><Cellular Aging><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Cellular Senescence><CoV-2><CoV2><Communicable Diseases><Communication><Data Science><Defect><Deterioration><Dissection><Economic Burden><Economics><Elderly><Elements><Event><Failure><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Genetic Models><Goals><Health><Health Care><Human><Immune><Immune response><Immune system><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Impairment><Individual><Infection><Infectious Agent><Infectious Diseases><Infectious Disorder><Informatics><Injury><Intervention><Intracellular Communication and Signaling><Knowledge><Laboratories><Length><Life><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphatic nodes><Maintenance><Malignant Neoplasms><Malignant Tumor><Mice><Mice Mammals><Modality><Modern Man><Molecular><Monitor><Murine><Mus><Natural regeneration><Output><Pathway interactions><Peripheral><Phenotype><Pre-Clinical Model><Preclinical Models><Process><Production><QOL><Quality of life><Reagent><Regeneration><Regenerative capacity><Rejuvenation><Replicative Senescence><Research><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Sampling><Savings><Science><Self Tolerance><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome related corona virus 2><Signal Transduction><Signal Transduction Systems><Signaling><Societies><Spleen><Spleen Reticuloendothelial System><Standardization><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Subcellular Process><T-Cell Development><T-Cell Ontogeny><T-Cells><T-Lymphocyte><T-Lymphocyte Development><Testing><Therapeutic><Thymus><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Transcript Expression Analyses><Transcript Expression Analysis><Translating><Translations><Tumor Cell><Virus><Wuhan coronavirus><advanced age><age associated><age associated alterations><age associated changes><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age specific><age specific alterations><age specific changes><aged><aged mice><aged mouse><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><analyze gene expression><animal tissue><autoimmune condition><autoimmune disorder><autoimmunity disease><biological signal transduction><central tolerance><changes with age><comparative><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 virus><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 virus><data sharing><design><designing><economic><effective intervention><elderly mice><experience><gene expression analysis><gene expression assay><geriatric><hCoV19><healthspan><healthy life span><high throughput analysis><host response><immune function><immune senescence><immune system function><immune system response><immunoresponse><immunosenescence><improved><infectious organism><injuries><life span><lifespan><lymph gland><lymph nodes><lymph organ><lymphatic organ><lymphnodes><lymphoid organ><malignancy><mortality><mouse model><murine model><nCoV2><neoplasm/cancer><neoplastic cell><novel><old mice><older adult><older adulthood><pathway><peripheral lymph organ><peripheral lymphoid organ><primary lymphatic organ><primary lymphoid organ><programs><regenerate><regeneration ability><regeneration capacity><rejuvenating intervention><rejuvenation approach><rejuvenation strategies><rejuvenation therapy><rejuvenation treatment><replicative aging><response><secondary lymph organ><secondary lymphatic organ><secondary lymphoid organ><senior citizen><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social role><statistical analysis><success><synergism><therapeutic rejuvenation><thymus derived lymphocyte><timeline><transcriptional profiling><translation>

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CHRISTIAN J PIKE

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

High-opportunity lead · 80/100

Likely hiring

Large award

Very recent

Active award

$1,041,827

FY 2026

Project Title

Dietary protection against APOE4 phenotypes in aging and Alzheimer's

Grant Number:

5R01AG084485-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The ɛ4 allele of apolipoprotein E (APOE4) is associated with accelerated aging and mortality as well increased vulnerability to Alzheimer’s disease (AD). Although the causal links between APOE4, aging, and AD risk remain to be fully defined, candidate mechanisms include regulation of energy metaboli...

Research Terms

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SHELLEY L BERGER

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

High-opportunity lead · 74/100

Likely hiring

Large award

Active award

Team-scale grant

$2,809,832

FY 2026

Project Title

Epigenetics of Aging and Age-Associated Diseases

Grant Number:

1P01AG092325-01

Activity Code:

P01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

In the previous active cycle of this PPG “Epigenetics of aging and age-associated diseases” (2018-2023), we proposed to focus on two main aspects of “epigenetics of aging”, namely chromostasis and regulation of the senescence-associated secretory phenotype (SASP) of senescent cells. This PPG coined...

Research Terms

<3-D><3-Dimensional><3D><Age><Aging><Area><Autoregulation><Body Tissues><Brain><Brain Nervous System><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Senescence><Cell Signaling><Cell model><Cells><Cellular Aging><Cellular Senescence><Cellular model><Chemotactic Cytokines><Chromatin><Coin><Cryo-electron Microscopy><Cryoelectron Microscopy><Cytoplasm><DNA><Dedications><Deoxyribonucleic Acid><Development><Diabetes Mellitus><Disease><Disorder><Electron Cryomicroscopy><Encephalon><Enhancers><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Fatty Liver><Fostering><Foundations><Funding><Future><Gene Expression><Gene Transcription><Genetic Transcription><Hepatic Cancer><Hepatic Failure><Homeostasis><Homologous Chemotactic Cytokines><Immune><Immunes><Immunoglobulin Enhancer-Binding Protein><Inflammatory><Intercrines><Intracellular Communication and Signaling><Length of Life><Liver><Liver Dysfunction><Liver Failure><Liver Steatosis><Longevity><Macromolecular Structure><Malignant neoplasm of liver><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic dysfunction><Mice><Mice Mammals><Molecular><Molecular Structure><Molecular Target><Murine><Mus><NF-kB><NF-kappa B><NF-kappaB><NFKB><Nature><Nuclear><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Nucleus><Paper><Pathway interactions><Phase><Phenotype><Physiological Homeostasis><Process><Productivity><Progress Reports><Proliferating><Publishing><RNA Expression><Regulation><Replicative Senescence><Risk Factors><Role><SIS cytokines><Signal Transduction><Signal Transduction Systems><Signaling><Single Crystal Diffraction><Stimulator of Interferon Genes><Stress><Structure><Talents><Testing><Thesaurismosis><Tissues><Transcription><Transcription Factor NF-kB><X Ray Crystallographies><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray/Neutron Crystallography><Xray Crystallography><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><ages><aging associated><aging induced epigenetic change><aging related><aging-associated epigenetic change><aging-related epigenetic change><biological signal transduction><cGAMP STING><cGAMP-STING><cGAMP/STING><cGAS/STING><chemoattractant cytokine><chemokine><chromatin remodeling><cryo-EM><cryoEM><cryogenic electron microscopy><cyclic GMP-AMP synthase/STING><cytokine><develop therapy><developmental><diabetes><epigenetic aging><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic regulation of aging><epigenetically><epigenome><falls><fatty liver disease><healthspan extending intervention><healthspan extending therapies><healthspan intervention><healthspan promoting intervention><healthspan promoting therapies><healthspan therapies><healthy aging intervention><hepatic body system><hepatic organ system><hepatic steatosis><hepatosteatosis><histone modification><improved><in vivo><inhibitor><innovate><innovation><innovative><insight><intervention development><intervention to promote healthy aging><interventions to improve healthspan><kappa B Enhancer Binding Protein><liver cancer><liver malignancy><malignant liver tumor><metabolism disorder><mouse model><murine model><novel><nuclear factor kappa beta><pathway><promoter><promotor><replicative aging><response><restraint><senescence><senescence and its associated secretory phenotype><senescence associated secretome><senescence associated secretory factors><senescence associated secretory pathway><senescence associated secretory phenotype><senescence associated secretory program><senescence associated secretory proteins><senescent><senescent associated secretome><senescent associated secretory phenotype><senescent cell><social role><therapy development><three dimensional><tool><treatment development>

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Doron Betel

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$840,466

FY 2026

Project Title

Novel strategies for induction of aging in human PSC-derived lineages for modeling Alzheimer's Disease

Grant Number:

5R01AG054720-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2017

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Alzheimer’s disease (AD) represents an increasing medical and societal problem affecting > 6 million patients in the US, with numbers continuing to grow due to the increase in average age and lifespan. Despite the urgent need, there are still only few therapeutic options available to...

Research Terms

<21+ years old><AD brain><AD dementia><AD model><AD pathology><AD patients><Address><Adult><Adult Human><Affect><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's pathology><Alzheimer's patient><Alzheimers Dementia><Astrocytes><Astrocytus><Astroglia><Atlases><Brain><Brain Nervous System><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><Cell Aging><Cell Body><Cell Line><Cell Reprogramming><Cell Senescence><Cell Senescence Induction><Cell model><CellLine><Cells><Cellular Aging><Cellular Senescence><Cellular model><Chemosensitization><Chemosensitization/Potentiation><Clinical Data><Clustered Regularly Interspaced Short Palindromic Repeats><Co-culture><Cocultivation><Coculture><Coculture Techniques><DNA mutation><Data><Data Bases><Data Set><Databases><Disease><Disease Progression><Disorder><Ectopic Expression><Embryo><Embryonic><Encephalon><Experimental Models><Gene Expression><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Diseases><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><Genetic defect><Genetic mutation><Glia><Glial Cells><Goals><HSV encephalitis><Herpes Simplex Encephalitis><Herpes encephalitis><Herpetic Encephalitis><Human><Human Genetics><Hutchinson-Gilford Disease><Hutchinson-Gilford Syndrome><In Vitro><Induced pluripotent stem cell derived neurons><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Late-Onset Disorder><Measures><Medical><Modeling><Modern Man><Motivation><Mutation><Nerve Cells><Nerve Unit><Nervous System><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic Body System><Neurologic Disorders><Neurologic Organ System><Neurological Disorders><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neurons><Non-neuronal cell><Nonneuronal cell><Paralysis Agitans><Parkinson><Parkinson Disease><Pathway interactions><Patients><Performance><Phenotype><Physiologic><Physiological><Potentiation><Premature Aging><Premature Senility Syndrome><Premature aging syndrome><Primary Parkinsonism><Primary Senile Degenerative Dementia><Process><Progeria><Publishing><RNA Expression><Recombinant DNA Technology><Rejuvenation><Replicative Senescence><Role><Route><Scoring Method><Strains Cell Lines><Syndrome><System><Tauopathies><Technology><Telomere Shortening><Testing><Therapeutic><Transcription><Work><adulthood><age associated><age associated alterations><age associated changes><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age specific><age specific alterations><age specific changes><aged><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging population><aging process><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><alzheimer model><amyloid pathology><astrocytic glia><autism model><behavior in vitro><cell age><cell type><cellular age><cellular aging induction><cellular reprogramming><cellular senescence induction><changes with age><clustered regularly interspaced short palindromic repeats screen><cohort><cultured cell line><data base><data integration><design><designing><disease model><disease phenotype><disorder model><drug discovery><engineered progenitor cells><engineered stem cells><fetal><genetic condition><genetic disorder><genetically engineered><genome mutation><genome scale><genome-wide><genomewide><herpes simplex virus 1 encephalitis><herpes simplex virus encephalitis><human data><human derived pluripotent stem cell><human disease><human model><human pluripotent stem cell><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSC technology><iPSCs><improved><in silico><in vitro Model><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><induced pluripotent stem cell technology><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><innovate><innovation><innovative><insight><late disease onset><late onset alzheimer><late onset disorder><life span><lifespan><loss of function><model of autism spectrum disorder><model of human><mutant><natural aging><nerve cement><neural inflammation><neurodegenerative phenotype><neuroinflammation><neuroinflammatory><neurological disease><neuronal><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><neuropathologic tau><neuropathological tau><new approaches><next generation><normal aging><normative aging><novel><novel approaches><novel strategies><novel strategy><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><pharmacologic><population aging><primary degenerative dementia><progenitor cell model><progenitor model><replicative aging><senescence induction><senile dementia of the Alzheimer type><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><telomere attrition><tool>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

LORENZ P. STUDER

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$840,466

FY 2026

Project Title

Novel strategies for induction of aging in human PSC-derived lineages for modeling Alzheimer's Disease

Grant Number:

5R01AG054720-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2017

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Alzheimer’s disease (AD) represents an increasing medical and societal problem affecting > 6 million patients in the US, with numbers continuing to grow due to the increase in average age and lifespan. Despite the urgent need, there are still only few therapeutic options available to...

Research Terms

<21+ years old><AD brain><AD dementia><AD model><AD pathology><AD patients><Address><Adult><Adult Human><Affect><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's pathology><Alzheimer's patient><Alzheimers Dementia><Astrocytes><Astrocytus><Astroglia><Atlases><Brain><Brain Nervous System><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><Cell Aging><Cell Body><Cell Line><Cell Reprogramming><Cell Senescence><Cell Senescence Induction><Cell model><CellLine><Cells><Cellular Aging><Cellular Senescence><Cellular model><Chemosensitization><Chemosensitization/Potentiation><Clinical Data><Clustered Regularly Interspaced Short Palindromic Repeats><Co-culture><Cocultivation><Coculture><Coculture Techniques><DNA mutation><Data><Data Bases><Data Set><Databases><Disease><Disease Progression><Disorder><Ectopic Expression><Embryo><Embryonic><Encephalon><Experimental Models><Gene Expression><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Diseases><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><Genetic defect><Genetic mutation><Glia><Glial Cells><Goals><HSV encephalitis><Herpes Simplex Encephalitis><Herpes encephalitis><Herpetic Encephalitis><Human><Human Genetics><Hutchinson-Gilford Disease><Hutchinson-Gilford Syndrome><In Vitro><Induced pluripotent stem cell derived neurons><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Late-Onset Disorder><Measures><Medical><Modeling><Modern Man><Motivation><Mutation><Nerve Cells><Nerve Unit><Nervous System><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic Body System><Neurologic Disorders><Neurologic Organ System><Neurological Disorders><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neurons><Non-neuronal cell><Nonneuronal cell><Paralysis Agitans><Parkinson><Parkinson Disease><Pathway interactions><Patients><Performance><Phenotype><Physiologic><Physiological><Potentiation><Premature Aging><Premature Senility Syndrome><Premature aging syndrome><Primary Parkinsonism><Primary Senile Degenerative Dementia><Process><Progeria><Publishing><RNA Expression><Recombinant DNA Technology><Rejuvenation><Replicative Senescence><Role><Route><Scoring Method><Strains Cell Lines><Syndrome><System><Tauopathies><Technology><Telomere Shortening><Testing><Therapeutic><Transcription><Work><adulthood><age associated><age associated alterations><age associated changes><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age specific><age specific alterations><age specific changes><aged><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging population><aging process><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><alzheimer model><amyloid pathology><astrocytic glia><autism model><behavior in vitro><cell age><cell type><cellular age><cellular aging induction><cellular reprogramming><cellular senescence induction><changes with age><clustered regularly interspaced short palindromic repeats screen><cohort><cultured cell line><data base><data integration><design><designing><disease model><disease phenotype><disorder model><drug discovery><engineered progenitor cells><engineered stem cells><fetal><genetic condition><genetic disorder><genetically engineered><genome mutation><genome scale><genome-wide><genomewide><herpes simplex virus 1 encephalitis><herpes simplex virus encephalitis><human data><human derived pluripotent stem cell><human disease><human model><human pluripotent stem cell><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSC technology><iPSCs><improved><in silico><in vitro Model><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><induced pluripotent stem cell technology><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><innovate><innovation><innovative><insight><late disease onset><late onset alzheimer><late onset disorder><life span><lifespan><loss of function><model of autism spectrum disorder><model of human><mutant><natural aging><nerve cement><neural inflammation><neurodegenerative phenotype><neuroinflammation><neuroinflammatory><neurological disease><neuronal><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><neuropathologic tau><neuropathological tau><new approaches><next generation><normal aging><normative aging><novel><novel approaches><novel strategies><novel strategy><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><pharmacologic><population aging><primary degenerative dementia><progenitor cell model><progenitor model><replicative aging><senescence induction><senile dementia of the Alzheimer type><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><telomere attrition><tool>

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Smita Bhatia

FRED HUTCHINSON CANCER CENTER, SEATTLE, WA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$798,501

FY 2026

Project Title

Immune aging and outcomes in adult survivors of childhood cancer

Grant Number:

1R01AG098480-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary: Childhood cancer survivors carry a high burden of morbidity resulting in a significant reduction in their lifespan. The chronic health conditions including congestive heart failure and coronary artery disease and frailty develop at an earlier age than would be expected in the general popula...

Research Terms

<21+ years old><AML - Acute Myeloid Leukemia><Acceleration><Acute Lymphoblastic Leukemia><Acute Lymphocytic Leukemia><Acute Lymphoid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><Adult><Adult Human><Age><Aging><Anthracycline><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Body Tissues><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Failure Congestive><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cells><Cellular Immune Function><Characteristics><Childhood><Childhood ALL><Childhood Acute Lymphoblastic Leukemia><Childhood Acute Lymphocytic Leukemia><Childhood Acute Lymphogenous Leukemia><Childhood Acute Lymphoid Leukemia><Childhood Cancer Survivor Study><Childhood Cancers><Chronic><Chronology><Clinical><Complex><Congestive Heart Failure><Coronary Arteriosclerosis><Coronary Artery Disease><Coronary Artery Disorder><Coronary Atherosclerosis><Development><Diabetes Mellitus><Dissection><Dysfunction><Dyslipidemias><Evaluation><Exhibits><Functional disorder><Future><General Population><General Public><Groups at risk><Health><Heart Decompensation><Heart Diseases><Heart Vascular><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><High Prevalence><Hodgkin Disease><Hodgkin Disorder><Hodgkin lymphoma><Hodgkin's><Hodgkin's Lymphoma><Hodgkin's disease><Hodgkins lymphoma><Human><Hypertension><Immune><Immune Targeting><Immune system><Immunes><Immunology><Individual><Inflammation><Inflammatory><Intervention><Intervention Studies><Intracellular Communication and Signaling><Investigators><L1 Lymphocytic Leukemia><Lead><Life><Life Expectancy><Link><Long-Term Survivors><Lymphoblastic Leukemia><Lymphoblastic Leukemia, Acute, L1><Lymphocytic Leukemia><Lymphoid Leukemia><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Hematologic Neoplasm><Malignant Lymphogranuloma><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant childhood cancer><Modern Man><Morbidity><Non-Hodgkin's Lymphoma><Nonhodgkins Lymphoma><Older Population><Outcome><Pathogenesis><Pb element><Pediatric ALL><Pediatric Acute Lymphoblastic Leukemia><Pediatric Acute Lymphocytic Leukemia><Pediatric Acute Lymphogenous Leukemia><Pediatric Acute Lymphoid Leukemia><People at risk><Persons at risk><Phenotype><Physiologic><Physiological><Physiopathology><Populations at Risk><Precursor Cell Lymphoblastic Leukemia><Precursor Lymphoblastic Leukemia><Process><Radiation><Research Personnel><Research Resources><Researchers><Resources><Risk Factors><Saint Jude><Saint Jude Children's Cancer Center><Saint Jude Children's Research Hospital><Signal Transduction><Signal Transduction Systems><Signaling><St. Jude><St. Jude Children's Cancer Center><St. Jude Children's Research Hospital><St. Jude Children's Research Hospital Comprehensive Cancer Center><St.Jude Children's Cancer Center><St.Jude Children's Research Hospital><St.Jude Children's Research Hospital Comprehensive Cancer Center><Survivors><Testing><Therapeutic><Tissues><Universities><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Work><accelerated aging><accelerated biological age><accelerated biological aging><acute granulocytic leukemia><acute lymphatic leukemia><acute lymphogenous leukemia><acute lymphomatic leukemia><acute myeloid leukemia><adulthood><adverse consequence><adverse outcome><age acceleration><ages><aging associated><aging related><atherosclerotic coronary disease><biological signal transduction><cancer diagnosis><cancer in a child><cancer in children><cardiac disease risk><cardiac disorder risk><cardiovascular disorder><cardiovascular risk><cardiovascular risk factor><cell based intervention><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><child with cancer><childhood cancer survivor><childhood malignancy><chronic heart failure><circulatory system><co-morbid><co-morbidity><cohort><comorbidity><comparator group><comparison group><coronary arterial disease><cost><cytokine><developmental><diabetes><frailty><heart disease risk><heart disorder><heart disorder risk><heavy metal Pb><heavy metal lead><high blood pressure><high dimensionality><high risk><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immune function><immune health><immune system health><improved><infant ALL><intervention research><interventional research><interventional study><interventions research><life span><lifespan><lymphatic leukemia><lymphogenous leukemia><malleable risk><modifiable risk><non-Hodgkins disease><novel><older adult><older adulthood><older groups><older individuals><older person><pathophysiology><pediatric><pediatric cancer><pediatric cancer survivor><pediatric malignancy><risk mitigation><senolytics><success><survivorship><tool><younger age>

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Kavita Madhav Dhodapkar

FRED HUTCHINSON CANCER CENTER, SEATTLE, WA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$798,501

FY 2026

Project Title

Immune aging and outcomes in adult survivors of childhood cancer

Grant Number:

1R01AG098480-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary: Childhood cancer survivors carry a high burden of morbidity resulting in a significant reduction in their lifespan. The chronic health conditions including congestive heart failure and coronary artery disease and frailty develop at an earlier age than would be expected in the general popula...

Research Terms

<21+ years old><AML - Acute Myeloid Leukemia><Acceleration><Acute Lymphoblastic Leukemia><Acute Lymphocytic Leukemia><Acute Lymphoid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><Adult><Adult Human><Age><Aging><Anthracycline><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Body Tissues><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Failure Congestive><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cells><Cellular Immune Function><Characteristics><Childhood><Childhood ALL><Childhood Acute Lymphoblastic Leukemia><Childhood Acute Lymphocytic Leukemia><Childhood Acute Lymphogenous Leukemia><Childhood Acute Lymphoid Leukemia><Childhood Cancer Survivor Study><Childhood Cancers><Chronic><Chronology><Clinical><Complex><Congestive Heart Failure><Coronary Arteriosclerosis><Coronary Artery Disease><Coronary Artery Disorder><Coronary Atherosclerosis><Development><Diabetes Mellitus><Dissection><Dysfunction><Dyslipidemias><Evaluation><Exhibits><Functional disorder><Future><General Population><General Public><Groups at risk><Health><Heart Decompensation><Heart Diseases><Heart Vascular><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoietic Cancer><High Prevalence><Hodgkin Disease><Hodgkin Disorder><Hodgkin lymphoma><Hodgkin's><Hodgkin's Lymphoma><Hodgkin's disease><Hodgkins lymphoma><Human><Hypertension><Immune><Immune Targeting><Immune system><Immunes><Immunology><Individual><Inflammation><Inflammatory><Intervention><Intervention Studies><Intracellular Communication and Signaling><Investigators><L1 Lymphocytic Leukemia><Lead><Life><Life Expectancy><Link><Long-Term Survivors><Lymphoblastic Leukemia><Lymphoblastic Leukemia, Acute, L1><Lymphocytic Leukemia><Lymphoid Leukemia><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Hematologic Neoplasm><Malignant Lymphogranuloma><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant childhood cancer><Modern Man><Morbidity><Non-Hodgkin's Lymphoma><Nonhodgkins Lymphoma><Older Population><Outcome><Pathogenesis><Pb element><Pediatric ALL><Pediatric Acute Lymphoblastic Leukemia><Pediatric Acute Lymphocytic Leukemia><Pediatric Acute Lymphogenous Leukemia><Pediatric Acute Lymphoid Leukemia><People at risk><Persons at risk><Phenotype><Physiologic><Physiological><Physiopathology><Populations at Risk><Precursor Cell Lymphoblastic Leukemia><Precursor Lymphoblastic Leukemia><Process><Radiation><Research Personnel><Research Resources><Researchers><Resources><Risk Factors><Saint Jude><Saint Jude Children's Cancer Center><Saint Jude Children's Research Hospital><Signal Transduction><Signal Transduction Systems><Signaling><St. Jude><St. Jude Children's Cancer Center><St. Jude Children's Research Hospital><St. Jude Children's Research Hospital Comprehensive Cancer Center><St.Jude Children's Cancer Center><St.Jude Children's Research Hospital><St.Jude Children's Research Hospital Comprehensive Cancer Center><Survivors><Testing><Therapeutic><Tissues><Universities><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Work><accelerated aging><accelerated biological age><accelerated biological aging><acute granulocytic leukemia><acute lymphatic leukemia><acute lymphogenous leukemia><acute lymphomatic leukemia><acute myeloid leukemia><adulthood><adverse consequence><adverse outcome><age acceleration><ages><aging associated><aging related><atherosclerotic coronary disease><biological signal transduction><cancer diagnosis><cancer in a child><cancer in children><cardiac disease risk><cardiac disorder risk><cardiovascular disorder><cardiovascular risk><cardiovascular risk factor><cell based intervention><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><child with cancer><childhood cancer survivor><childhood malignancy><chronic heart failure><circulatory system><co-morbid><co-morbidity><cohort><comorbidity><comparator group><comparison group><coronary arterial disease><cost><cytokine><developmental><diabetes><frailty><heart disease risk><heart disorder><heart disorder risk><heavy metal Pb><heavy metal lead><high blood pressure><high dimensionality><high risk><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immune function><immune health><immune system health><improved><infant ALL><intervention research><interventional research><interventional study><interventions research><life span><lifespan><lymphatic leukemia><lymphogenous leukemia><malleable risk><modifiable risk><non-Hodgkins disease><novel><older adult><older adulthood><older groups><older individuals><older person><pathophysiology><pediatric><pediatric cancer><pediatric cancer survivor><pediatric malignancy><risk mitigation><senolytics><success><survivorship><tool><younger age>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

GRIGORI N ENIKOLOPOV

STATE UNIVERSITY NEW YORK STONY BROOK, STONY BROOK, NY

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$775,592

FY 2026

Project Title

Endogenous barcoding to determine complex dynamics of adult neurogenesis in aging and Alzheimer's disease

Grant Number:

5R01AG076937-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT New neurons in the adult human and animal hippocampus have been implicated in several cognitive functions. These functions are profoundly impaired by the loss or insufficient production of new neurons. Neurons are produced after a prolonged series of transitions including the activation, p...

Research Terms

<21+ years old><AD dementia><AD model><AD pathology><Acceleration><Address><Adult><Adult Human><Adverse effects><Aging><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's pathology><Alzheimers Dementia><Ammon Horn><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Animals><Anticonvulsant Agent><Anticonvulsant Drugs><Anticonvulsants><Anticonvulsive Agents><Anticonvulsive Drugs><Aβ><Bar Codes><Birth><Body Tissues><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Cell Body><Cell Differentiation><Cell Differentiation process><Cells><Clinical Treatment Moab><Clonal Expansion><Clonality><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complement><Complement Proteins><Complex><Cornu Ammonis><DNA><DNA Recombination><Deoxyribonucleic Acid><Development><Disease><Disorder><Disturbance in cognition><Drug usage><Drugs><EAA Antagonists><Encephalon><Encephalon Diseases><Excitatory Amino Acid Antagonists><Expression Signature><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profile><Gene Expression Profiling><Genes><Genetic Recombination><Glutamate Antagonists><Glutamate Receptor Antagonists><Goals><Hippocampus><Human><Impaired cognition><Impairment><Individual><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Knowledge><Label><Levetiracetam><Life Cycle><Life Cycle Stages><Link><Maintenance><Malignant><Malignant - descriptor><Medication><Memantin><Memantine><Methods><Mice><Mice Mammals><Modality><Modeling><Modern Man><Monoclonal Antibodies><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neural Stem Cell><Neurocyte><Neurons><Non-Polyadenylated RNA><Outcome><Parturition><Pharmaceutical Preparations><Physical activity><Primary Senile Degenerative Dementia><Production><Progenitor Cells><Proliferating><RNA><RNA Gene Products><Recombination><Regulation><Reporter><Resolution><Ribonucleic Acid><Running><Scheme><Series><System><Techniques><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><a beta peptide><abeta><adult animal><adult neurogenesis><adulthood><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age related alterations><age related changes><age specific alterations><age specific changes><aged brain><aging associated><aging associated alterations><aging associated changes><aging associated disease><aging associated disorders><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related><aging related alterations><aging related changes><aging related disease><aging related disorders><aging specific alterations><aging specific changes><alterations with age><alzheimer model><amyloid beta><amyloid-b protein><analyze gene expression><barcode><beta amyloid fibril><cellular differentiation><changes with age><cognitive dysfunction><cognitive function><cognitive loss><cohort><combinatorial><complementation><developmental><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><drug use><drug/agent><gene expression analysis><gene expression assay><gene expression pattern><gene expression signature><global gene expression><global transcription profile><hippocampal><instrument><life course><life span><lifespan><mAbs><mature animal><model of animal><monoclonal Abs><mouse genome><mouse model><murine model><natural aging><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurodevelopment><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new approaches><normal aging><normative aging><novel approaches><novel strategies><novel strategy><old age><primary degenerative dementia><progenitor and neural stem cells><progenitor cell division><progenitor cell renewal><progenitor division><progenitor renewal><resolutions><seizure drug><seizure medication><senile dementia of the Alzheimer type><single cell analysis><soluble amyloid precursor protein><stem and progenitor cell division><stem and progenitor cell renewal><stem cell depletion><stem cell division><stem cell exhaustion><stem cell fatigue><stem cell renewal><stem cells><tool><transcriptional profile><transcriptional profiling><transcriptional signature><transcriptome><transcriptomics>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

L Elliot Elliot Hong

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$764,880

FY 2026

Project Title

The Vascular Axis in Schizophrenia Brain-Body Aging

Grant Number:

5R01MH133812-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/8/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary People with schizophrenia spectrum disorders have a shorter lifespan and higher morbidity and mortality than the general population, with cardiovascular conditions on top of the leading causes. Brain imaging research has revealed accelerated age-related brain changes in patients with...

Research Terms

<3-D><3-Dimensional><3D><Acceleration><Access to Care><Age><Aging><Antipsychotic Agents><Antipsychotic Drugs><Antipsychotics><Apoplexy><Arteries><Astrocytes><Astrocytus><Astroglia><Autopsy><Autoregulation><Biological Markers><Biology><Blood - brain barrier anatomy><Blood Vessel Imaging><Blood Vessels><Blood brain barrier dysfunction><Blood-Brain Barrier><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain Trauma><Brain Vascular><Brain Vascular Accident><Brain imaging><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cause of Death><Cell Body><Cells><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cerebrovascular system><Cerebrum><Data><Diffusion><Disease><Disorder><Dysfunction><Early Intervention><Encephalon><Encephalon Diseases><Endothelial Cells><Endothelium><Functional disorder><General Population><General Public><Goals><Guide prevention><Health><Health Services Accessibility><Heart Vascular><Hemato-Encephalic Barrier><Homeostasis><Hydrogen Oxide><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Investigation><Life><Long-term cohort><Longitudinal cohort><Major Tranquilizers><Major Tranquilizing Agents><Measures><Mediating><Mediation><Medical><Metabolic syndrome><Methods><Modeling><Morbidity><Negotiating><Negotiation><Neuroleptic Agents><Neuroleptic Drugs><Neuroleptics><Outcome><Pathway interactions><Patients><Peripheral><Persons><Physiologic pulse><Physiological Homeostasis><Physiopathology><Premature Mortality><Preventative intervention><Prevention><Pulse><Reporting><Research><Risk Factors><Schizophrenia><Schizophrenic Disorders><Smoking><Stress><Stroke><System><Techniques><Testing><Time><Traumatic Brain Injury><Water><White Matter Disease><accelerated aging><accelerated biological age><accelerated biological aging><access to health services><access to services><access to treatment><accessibility to health services><adult youth><age acceleration><age associated><age associated alterations><age associated changes><age associated effects><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age effect><age group><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related effects><age specific><age specific alterations><age specific changes><aged brain><ages><aging associated><aging associated alterations><aging associated changes><aging associated disease><aging associated disorders><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging related><aging related alterations><aging related changes><aging related disease><aging related disorders><aging specific alterations><aging specific changes><allostatic load><alterations with age><arterial spin labeling><arterial spin tagging><arterial stiffening><arterial stiffness><artery stiffening><artery stiffness><astrocytic glia><availability of services><bio-markers><biologic marker><biomarker><blood vessels in the brain><bloodbrain barrier><brain attack><brain blood vessels><brain vasculature><brain visualization><burden of disease><burden of illness><cardiovascular disorder><care access><cerebral><cerebral blood vessel><cerebral vascular><cerebral vascular accident><cerebral vasculature><cerebro-vascular><cerebrovascular><cerebrovascular accident><cerebrovascular vessels><cerebrovasculature><changes with age><circulatory system><co-morbid><co-morbidity><comorbidity><dementia praecox><diffused><diffuses><diffusing><diffusions><disease associated with aging><disease burden><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><early onset><endothelial dysfunction><gray matter><health service access><health services availability><impact of age><influence of age><insight><intervention for prevention><life span><lifespan><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><mortality><necropsy><neural imaging><neuro-imaging><neuroimaging><neurological imaging><novel><older adult><older adulthood><pathophysiology><pathway><postmortem><premature><prematurity><prevention intervention><preventional intervention strategy><preventive intervention><reactive hyperemia><schizophrenia spectrum><schizophrenia spectrum disorder><schizophrenic><screening><screenings><service availability><sex><stroked><strokes><substantia alba><substantia grisea><three dimensional><traumatic brain damage><treatment access><vascular><vascular contributions><vascular imaging><vasculature Imaging><white matter><white matter change><young adult><young adult age><young adulthood>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Emilia Favuzzi

YALE UNIVERSITY, NEW HAVEN, CT

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$746,160

FY 2026

Project Title

Impact of peripheral inflammation on microglia and neurons in aging

Grant Number:

1R01AG098889-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/20/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Epidemiological evidence links peripheral inflammation to an increased risk of dementia, yet the mechanisms underlying this association remain unclear. Although peripheral immune challenges can amplify neuroinflammation and accelerate cognitive decline, we still do not under...

Research Terms

View Full Project Details on NIH Reporter

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Amar Sahay

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$727,096

FY 2026

Project Title

Targeting neurogenesis-inhibition coupling to improve memory in aging

Grant Number:

5R01AG076612-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The hippocampus plays a critical role in the formation of episodic memories by generating distinct, conjunctive representations of (spatial and social) experiences and transferring these representations to prefrontal cortical sites for memory storage or consolidation. Age-related cog...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Ammon Horn><Behavioral Paradigm><Benign senescent forgetfulness><CHD7><CHD7 gene><Cell Body><Cells><Chromatin><Chromodomain Helicase DNA-Binding Protein 7><Cognitive><Cognitive Discrimination><Communities><Connector Neuron><Cornu Ammonis><Coupling><Data><Dentate Fascia><Development><Discrimination><Episodic memory><Fascia Dentata><Female><Frequencies><Genetic><Goals><Grant><Gyrus Dentatus><Hippocampus><Human><Hyperactivity><Hypothalamic structure><Hypothalamus><Impairment><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><KIAA1416><Maps><Mediating><Memory><Memory Deficit><Memory Loss><Memory impairment><Mice><Mice Mammals><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurosciences><Parvalbumins><Play><Prefrontal Cortex><Property><Publishing><Research Resources><Resources><Ribo-seq><Rodent><Rodentia><Rodents Mammals><Role><Route><Site><Testing><Update><Viral><adulthood><age associated><age associated cognitive impairment><age associated memory decline><age associated memory deficit><age correlated><age dependent><age linked><age related><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related memory dysfunction><age reversal><age specific><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><aged><aged mice><aged mouse><aging associated><aging related><aging related cognitive decline><aging reversal><alleviate age related><alleviate aging><ameliorating aging><candidate validation><counter age related><counter aging><counteract age related><counteract aging><declining cognitive functions with aging><dentate gyrus><design><designing><developmental><elderly mice><experience><gain of function><genetic approach><genetic strategy><granule cell><hippocampal><hypothalamic><improved><in vivo><male><memory consolidation><memory decline><memory dysfunction><memory process><memory processing><memory recognition><mid life><mid-life><middle age><middle aged><midlife><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><molecular profile><molecular signature><neural circuit><neural circuitry><neurocircuitry><neurogenesis><neuronal><neuronal excitability><non-human primate><nonhuman primate><novel><old mice><optogenetics><overexpress><overexpression><patch clamp><programs><recruit><response><reverse age><reverse aging><reverse aging effects><reversible aging><ribosome footprint profiling><ribosome profiling><social><social role><synaptic circuit><synaptic circuitry><tool><♀><♂>

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Marcelo Andres Wood

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$721,033

FY 2026

Project Title

Investigating the interface of epigenetics and metabolism underlying memory formation in the adult, aging, and AD brain

Grant Number:

5R01AG076835-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract The ability to learn, consolidate and retrieve information begins to decline with normal aging, a major risk factor for Alzheimer’s Disease (AD) and dementia. In addition to aging, sedentary behavior ranks first in the US and third in the world as a risk factor for causing c...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD brain><AD dementia><AD model><AD risk><AD risk factor><ATAC sequencing><ATAC-seq><ATACseq><Acceleration><Acetyl CoA><Acetyl Coenzyme A><Acetyl Coenzyme A Carboxylase><Acetyl-CoA Carboxylase><Acetylation><Adult><Adult Human><Affect><Age><Aged 65 and Over><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Ammon Horn><Assay for Transposase-Accessible Chromatin using sequencing><BDNF><Behavior><Brain><Brain Nervous System><Brain-Derived Neurotrophic Factor><Cell Communication and Signaling><Cell Culture Techniques><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cell Signaling><Cellular Function><Cellular Physiology><Cellular Process><Censuses><Chromatin><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Data><Dementia><Disturbance in cognition><Encephalon><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equilibrium><Exercise><Feedback><Female><Frequencies><Future><Gene Action Regulation><Gene Down-Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Goals><Health><Hippocampus><Histone Acetylation><Histone H3><Impaired cognition><Impairment><Individual><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><L-Lysine><Learning><Long-Term Potentiation><Lysine><Measures><Mediating><Memory><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Methylation><Mice><Mice Mammals><Modeling><Modification><Molecular><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Transmission><Neurocyte><Neurons><Nucleus><Pathway interactions><Pattern><Population><Primary Senile Degenerative Dementia><RNA Seq><RNA sequencing><RNAseq><Regulation><Reporting><Research><Risk Factors><S-acetate Coenzyme A><Sedentary behavior><Sedentary life-style><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Synaptic Transmission><Synaptic plasticity><Therapeutic><Time><Transcription Repression><United States><Update><Wild Type Mouse><Woman><Work><above age 65><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age correlated><age dependent><age linked><age of 65 years onward><age related><age specific><aged 65 and greater><aged 65+><aged brain><aged hippocampus><aged ≥65><ages><aging brain><aging hippocampus><alzheimer model><alzheimer risk><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><balance><balance function><biological signal transduction><brain health><cell culture><cell cultures><cognitive dysfunction><cognitive loss><design><designing><epigenetic regulation><epigenetically><epigenome><experience><gene repression><hippocampal><histone modification><human old age (65+)><improved><insight><life span><lifespan><long-term memory><male><malleable risk><memory consolidation><memory process><memory processing><modifiable risk><mouse model><murine model><natural aging><neuronal><new approaches><normal aging><normative aging><novel><novel approaches><novel strategies><novel strategy><over 65 years><pathway><pharmacologic><prevent><preventing><primary degenerative dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><sedentary lifestyle><senile dementia of the Alzheimer type><sex><spatial memory><therapeutic agent development><therapeutic development><transcriptome sequencing><transcriptomic sequencing><wildtype mouse><≥65 years><♀><♂>

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AMY JO WAGERS

HARVARD UNIVERSITY, CAMBRIDGE, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Recent

Active award

$707,230

FY 2026

Project Title

Disrupted Communication Between Blood Cells and Non-blood Organs as a Mediator of Aging Pathologies

Grant Number:

5U01AG086163-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY: In this project, we seek to test the hypothesis that age-related perturbation of interorgan communication signals emanating from the hematopoietic (blood-forming) system may be a common driver of age-associated dysfunction across the body’s major organ systems. This possibility is b...

Research Terms

<85+ years old><Affect><Age><Age of Onset><Age related pathologies><Aging><Animals><Assay><Bioassay><Biological Assay><Blood><Blood Cells><Blood Reticuloendothelial System><Blood Serum><Blood monocyte><Body System><Body Tissues><Brain><Brain Nervous System><CRISPR><CRISPR/Cas system><Cardiac><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication and Signaling><Cell Function><Cell Lineage><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Clinical><Clonal Expansion><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Clonality><Clone Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><Cre Lox technology><Cre LoxP system><Cre lox recombination><Cre lox recombination system><Cre lox system><Cre recombinase/LoxP technology><Cre system><DNA mutation><Data Set><Dependence><Development><Diathesis><Disease><Disease susceptibility><Disorder><Disturbance in cognition><Dysfunction><Elderly><Encephalon><Event><Exhibits><Functional disorder><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Targeting><Genes><Genetic Change><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Goals><Heart><Heart Vascular><Hematologic Body System><Hematologic Organ System><Hematopoietic><Hematopoietic Body System><Hematopoietic System><Human><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune system><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Impaired cognition><In Situ><Individual><Intracellular Communication and Signaling><Link><Macrophage><Marrow monocyte><Mediator><Mice><Mice Mammals><Modern Man><Molecular><Monitor><Murine><Mus><Muscle><Muscle Tissue><Musculoskeletal><Mutagenesis><Mutagenesis Molecular Biology><Mutate><Mutation><Mφ><Neurologic><Neurological><Organ><Organ System><Outcome><Parabiosis><Pathologic><Pathology><Pathway interactions><Penetrance><Peripheral Blood Cell><Phenotype><Physiopathology><Prevalence><Production><Property><Proteome><Relative Risks><Risk><Role><Serum><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Skeletal Muscle><Somatic Mutation><Specificity><Subcellular Process><System><T-Cells><T-Lymphocyte><Testing><Time><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Transgenes><Virus><Voluntary Muscle><Work><advanced age><age 85 and greater><age 85 and older><age associated><age associated alterations><age associated changes><age associated difference><age associated disease><age associated disorder><age associated effects><age associated impairment><age associated pathologies><age based difference><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent difference><age dependent disease><age dependent disorder><age dependent impairment><age dependent pathologies><age dependent variation><age difference><age effect><age induced alterations><age induced changes><age induced pathologies><age linked><age related><age related alterations><age related changes><age related difference><age related effects><age related human disease><age related variation><age reversal><age specific><age specific alterations><age specific changes><age specific difference><age-related disease><age-related disorder><age-related impairment><aged 85 and greater><aged 85 and older><ages><aging associated><aging associated alterations><aging associated changes><aging associated pathologies><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging dependent pathologies><aging effect><aging induced alterations><aging induced changes><aging induced pathologies><aging pathologies><aging related><aging related alterations><aging related changes><aging related pathologies><aging reversal><aging specific alterations><aging specific changes><alleviate age related><alleviate aging><alterations with age><ameliorating aging><analyze gene expression><biological sex><biological signal transduction><cell type><changes with age><circulatory system><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><cognitive dysfunction><cognitive loss><counter age related><counter aging><counteract age related><counteract aging><developmental><differ by age><difference across age><difference in age><driver lesion><driver mutation><drivers of aging><experiment><experimental research><experimental study><experiments><gene editing method><gene editing methodology><gene editing platform><gene editing strategy><gene editing system><gene editing techniques><gene editing technology><gene editing tools><gene expression analysis><gene expression assay><gene-editing approach><gene-editing toolkit><genome mutation><geriatric><gerodriver><hematopoietic cell clones><hematopoietic stem cell clonality><hemopoietic><human data><human very old age (85+)><impact of age><in vivo><influence of age><insight><liability to disease><monocyte><muscle system><muscular><muscular system><mutant><mutational status><novel><pathophysiology><pathway><premature><prematurity><prevent><preventing><reverse age><reverse aging><reverse aging effects><reversible aging><senior citizen><single cell next generation sequencing><single cell sequencing><social role><somatic variant><therapeutic target><thymus derived lymphocyte><transcriptional profiling><transgene><variation by age><very old age>

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Anjana Rao

LA JOLLA INSTITUTE FOR IMMUNOLOGY, LA JOLLA, CA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Recent

Active award

$658,800

FY 2026

Project Title

Dysregulation of TET dioxygenase function as a source of aberrant transposable element expression during human aging

Grant Number:

5U01AI180152-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/20/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract It is well established that aging is accompanied by chronic low-grade inflammation that correlates well with mortality and morbidity, but the association between aging and inflammation is not well understood. Similarly, changes in DNA cytosine methylation occur reproducibly with age, sugges...

Research Terms

<2-ketoglutarate><2-oxoglutarate><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Address><Age><Aged 65 and Over><Aging><Area><Biology><Biology of Aging><Blood Serum><Blood monocyte><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cancers><Cell Aging><Cell Body><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Chronic><Chronology><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Communities><Cytosine><DNA><DNA Damage><DNA Injury><DNA Methylation><DNA Methyltransferase><DNA Modification><DNA Modification Methylases><DNA Modification Methyltransferases><DNA Modification Process><DNA Transposable Elements><DNA mutation><DNA-Methyltransferases><DNMT3a><Data><Deoxyribonucleic Acid><Development><Dioxygenases><Dnmt><Dysfunction><Enhancers><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Family><Fe element><Functional disorder><Future><Gene Deletion><Genes><Genetic Change><Genetic defect><Genetic mutation><Genome><Genomic Segment><GrimAge clock><Hannum clock><Heterochromatin><Horvath clock><Human><Immune><Immunes><Inflammaging><Inflammation><Inflammatory><Inflammatory Response><Intervention><Iron><Link><Long-term cohort><Longitudinal cohort><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Marrow monocyte><Mental Depression><Methylation><Mice><Mice Mammals><Modern Man><Modification Methylases><Morbidity><Murine><Mus><Mutation><Myeloid Cells><Oncogenesis><Oxidases><Pattern><PhenoAge clocks><Physiology><Physiopathology><Population><Proteins><Replicative Senescence><Repression><Reproducibility><Sampling><Serum><Site><Site-Specific DNA-methyltransferase><Somatic Cell><Source><Sterility><Stress><System><T4 Cells><T4 Lymphocytes><Testing><Tet><Tetanus Helper Peptide><Transposable Elements><above age 65><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age of 65 years onward><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><age-related inflammation><aged 65 and greater><aged 65+><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aged ≥65><ages><aging associated inflammation><aging population><aging process><alpha ketoglutarate><cancer cell><cell age><cellular age><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><cohort><cytokine><demethylation><depression><derepression><design><designing><developmental><epigenetic age clocks><epigenetic clock><epigenetic molecular clocks><epigenetically><experiment><experimental research><experimental study><experiments><gene deletion mutation><genome mutation><genome scale><genome segment><genome-wide><genomewide><genomic region><hDNA methyltransferase 3a><hallmarks of aging><healthspan><healthy life span><hematopoietic cell clones><hematopoietic stem cell clonality><human old age (65+)><improved><in vivo><inflamm-ageing><inflamm-aging><inflammation associated with aging><insoluble aggregate><interest><malignancy><methyl group><methylation clock><mid life><mid-life><middle age><middle aged><midlife><monocyte><mortality><mouse model><murine model><neoplasm/cancer><novel><over 65 years><pathogen><pathophysiology><pillars of aging><population aging><promoter><promotor><protein aggregate><protein aggregation><rational design><replicative aging><senescent cell><sterile><tissue repair><tumorigenesis><α-ketoglutarate><α-oxoglutarate><αKG><≥65 years>

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BELA ANAND-APTE

CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$615,928

FY 2026

Project Title

Mechanobiology of Bruchs membrane during aging: Implications for age-related retinal degenerations.

Grant Number:

1R01EY038520-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Aging is a significant risk factor for age-related macular degeneration AMD, a leading cause of blindness among the elderly. Aging and AMD induce progressive changes in Bruch’s membrane but to varying extents. There is increasing evidence that the physical properties of tissues, part...

Research Terms

<3-D><3-Dimensional><3D><Actomyosin><Age><Age related macular degeneration><Age-Related Maculopathy><Aging><Amino Acids><Autoregulation><Biological><Biological Markers><Biomechanics><Blindness><Body Tissues><Bruch Membrane><Bruch's basal membrane structure><Bruch's membrane><Bruchs membrane><Cancers><Cell Body><Cell-Extracellular Matrix><Cells><Complex><Data><Disease><Disease Reservoirs><Disorder><ECM><Elderly><Extracellular Matrix><Extracellular Matrix Proteins><Eye><Eyeball><Fundus dystrophy><Glycolysis><Health><Homeostasis><Human><Inferior><Intermediary Metabolism><Lamina Basalis Choroideae><MMPs><Malignant Neoplasms><Malignant Tumor><Maps><Matrix Metalloproteinases><Mechanics><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Modern Man><Molecular><Morphogenesis><Murine><Mus><Nasal><Nasal Passages Nose><Nose><Organ><Pathogenesis><Pathology><Pathway interactions><Physiologic><Physiological><Physiological Homeostasis><Physiology><Play><Property><Proteins><Publishing><Regulation><Reporting><Respiratory System, Nose, Nasal Passages><Risk Factors><Role><Sorsby's fundus dystrophy><Structure><Supporting Cell><Testing><Tissues><Viscosity><advanced age><age associated><age associated decline><age associated disease><age associated disorder><age associated impairment><age associated retinal degeneration><age associated retinal degenerative disease><age correlated><age dependent><age dependent decline><age dependent disease><age dependent disorder><age dependent impairment><age dependent macular degeneration><age dependent retinal degeneration><age induced macular degeneration><age linked><age related><age related decline><age related human disease><age related macular disease><age related macular dystrophy><age related retinal degeneration><age related retinal degenerative disease><age specific><age-related disease><age-related disorder><age-related impairment><ages><aging associated><aging process><aging related><aging related retinal degeneration><aminoacid><bio-markers><biologic><biologic marker><biomarker><biomechanical><crosslink><decline with age><geriatric><insight><interest><macula><macular><malignancy><mechanic><mechanical><mechanical force><mechanical properties><morphogenetic process><neoplasm/cancer><pathway><physical property><scaffold><scaffolding><senile macular disease><senior citizen><social role><spatial and temporal><spatial temporal><spatiotemporal><three dimensional><vision loss><visual loss>

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Qi yang

RUTGERS BIOMEDICAL AND HEALTH SCIENCES, Newark, NJ

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$614,458

FY 2026

Project Title

The development and function of aging-associate innate lymphoid cells in the choroid plexus

Grant Number:

4R01AG078459-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract The goal of this project is to understand the development and function of aging-associate lymphocytes. This proposal focuses on group 2 innate lymphoid cells (ILC2) that accumulate in the choroid plexus (CP) with aging. Aging is a complicated process associated with profound...

Research Terms

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SHIN-ICHIRO IMAI

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Recent

Active award

$609,383

FY 2026

Project Title

The intertissue communication between the hypothalamus and adipose tissue for mammalian aging and longevity control

Grant Number:

5U01AG086196-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Recent studies in model organisms have demonstrated that the intertissue communications play a critical role in the regulation of aging and longevity. In mammals, we have demonstrated that the intertissue communication between the hypothalamus and adipose tissue, particularly mediated by ex...

Research Terms

<3-Pyridinecarboxamide><Acceleration><Address><Adipose tissue><Affect><Age><Aging><Applications Grants><Body Tissues><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cell Senescence><Cell Signaling><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Communication><Cyclic GMP-Dependent Protein Kinases><Cytoplasm><Death Rate><Deterioration><Dysfunction><Enzyme Gene><Enzymes><Fatty Tissue><Feedback><Functional disorder><Genes><Genetic><Grant Proposals><Guanosine Cyclic 3',5'-Phosphate-Dependent Protein Kinase><Guanosine Cyclic Monophosphate-Dependent Protein Kinases><Hypothalamic structure><Hypothalamus><Immune><Immunes><Increase lifespan><Intracellular Communication and Signaling><Length of Life><Levarterenol><Levonorepinephrine><Lipolysis><Longevity><Lymphoid Cell><Mammalia><Mammals><Mediating><Mice><Mice Mammals><MicroRNAs><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Physiology><Neural Cell><Neurocyte><Neurologic function><Neurological function><Neurons><Niacinamide><Nicotinamide><Nicotinamidum><Nicotinic acid amide><Nicotylamide><Noradrenaline><Norepinephrine><Nucleus><Outcome><Outcome Study><Pellagra-Preventing Factor><Phenotype><Physiologic><Physiological><Physiopathology><Play><Population><Protein Kinase G><Regulation><Replicative Senescence><Reporting><Research><Research Proposals><Role><Running><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Sympathetic Nervous System><Time><Tissues><Transplantation><Visceral><Vitamin B 3><Vitamin B3><Vitamin PP><adipose><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged mice><aged mouse><ages><aging delay><aging preventive intervention><anti-aging intervention><attenuate aging><biological signal transduction><boost longevity><cGMP kinase><cGMP-Dependent Protein Kinases><decelerate aging><delay age related><elderly mice><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><extracellular><extracellular vesicles><foster longevity><hypothalamic><improve lifespan><improve longevity><interventions targeting aging><life span><lifespan><lifespan extension><miRNA><model organism><mortality rate><nervous system function><neuronal><old mice><pathophysiology><pause aging><postpone age related><prolong lifespan><prolong longevity><promote lifespan><promote longevity><replicative aging><retards aging><senescence and its associated secretory phenotype><senescence associated secretome><senescence associated secretory factors><senescence associated secretory pathway><senescence associated secretory phenotype><senescence associated secretory program><senescence associated secretory proteins><senescent associated secretome><senescent associated secretory phenotype><senescent cell><slow aging><slow down aging><slow the rate of aging><social role><support longevity><transplant><white adipose tissue><yellow adipose tissue>

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Camila Margarita Manrique Acevedo

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$603,556

FY 2026

Project Title

SGLT2 inhibition as a therapeutic strategy to reverse arterial stiffening in aging

Grant Number:

5R01AG082413-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is the main cause of death in older adults in the US and the burden of aging- associated CVD is expected to grow as the percentage of the older population steadily grows. A key characteristic of vascular aging is arterial stiffening, which is a c...

Research Terms

<ATP-protein phosphotransferase><Actin Filaments><Actins><Address><Age Years><Aging><Arteries><Blood Vessels><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cause of Death><Cell-Extracellular Matrix><Characteristics><Clinical Trials><Co-Transporters><Collagen><D-Glucose><Dephosphorylation><Deposit><Deposition><Development><Dextrose><Diabetes Mellitus><Down-Regulation><Drugs><ECM><Event><Extracellular Matrix><F-Actin><Family member><Female><Filamentous Actin><GeneHomolog><Glucose><Goals><Heart Vascular><Heart failure><Homolog><Homologous Gene><Homologue><Kidney><Kidney Urinary System><Kinase Family Gene><Knowledge><LIM Domain Kinase 1><LIM kinase><LIMK protein><LIMK-1><Leiomyocyte><Mediating><Medication><Microfilaments><Molecular><Monomeric G-Proteins><Monomeric GTP-Binding Proteins><Morbidity><Myofilaments><Na element><Older Population><Pathogenesis><Pathway interactions><Patients><Pharmaceutical Preparations><Phosphorylation><Polymers><Protein Dephosphorylation><Protein Kinase><Protein Phosphorylation><Publishing><Reducing Agents><Reductants><Research><Role><SGLT 2 inhibitor><SGLT2i><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Sodium><Sodium glucose co-transporter 2 inhibitor><Stress Fibers><Testing><Therapeutic><Time><Vascular Smooth Muscle><Vascular aging><Vascular remodeling><age reversal><aging associated><aging related><aging reversal><alleviate age related><alleviate aging><ameliorating aging><arterial stiffening><arterial stiffness><artery stiffening><artery stiffness><cardiac failure><cardiovascular disorder><cardiovascular effects><circulatory system><cofilin><cohort><counter age related><counter aging><counteract age related><counteract aging><depolymerization><design><designing><determine efficacy><developmental><diabetes><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy testing><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><gain of function><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><glycogen synthase a kinase><hydroxyalkyl protein kinase><in vivo><loss of function><male><mortality><mouse model><murine model><older adult><older adulthood><older groups><older individuals><older person><pathway><pharmacologic><phosphorylase b kinase kinase><polymer><polymeric><polymerization><prevent><preventing><randomized placebo-controlled clinical trial><renal><reverse age><reverse aging><reverse aging effects><reversible aging><rho><social role><symporter><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><vascular><vasculature aging><♀><♂>

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Luis A Martinez-Lemus

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$603,556

FY 2026

Project Title

SGLT2 inhibition as a therapeutic strategy to reverse arterial stiffening in aging

Grant Number:

5R01AG082413-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is the main cause of death in older adults in the US and the burden of aging- associated CVD is expected to grow as the percentage of the older population steadily grows. A key characteristic of vascular aging is arterial stiffening, which is a c...

Research Terms

<ATP-protein phosphotransferase><Actin Filaments><Actins><Address><Age Years><Aging><Arteries><Blood Vessels><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cause of Death><Cell-Extracellular Matrix><Characteristics><Clinical Trials><Co-Transporters><Collagen><D-Glucose><Dephosphorylation><Deposit><Deposition><Development><Dextrose><Diabetes Mellitus><Down-Regulation><Drugs><ECM><Event><Extracellular Matrix><F-Actin><Family member><Female><Filamentous Actin><GeneHomolog><Glucose><Goals><Heart Vascular><Heart failure><Homolog><Homologous Gene><Homologue><Kidney><Kidney Urinary System><Kinase Family Gene><Knowledge><LIM Domain Kinase 1><LIM kinase><LIMK protein><LIMK-1><Leiomyocyte><Mediating><Medication><Microfilaments><Molecular><Monomeric G-Proteins><Monomeric GTP-Binding Proteins><Morbidity><Myofilaments><Na element><Older Population><Pathogenesis><Pathway interactions><Patients><Pharmaceutical Preparations><Phosphorylation><Polymers><Protein Dephosphorylation><Protein Kinase><Protein Phosphorylation><Publishing><Reducing Agents><Reductants><Research><Role><SGLT 2 inhibitor><SGLT2i><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Sodium><Sodium glucose co-transporter 2 inhibitor><Stress Fibers><Testing><Therapeutic><Time><Vascular Smooth Muscle><Vascular aging><Vascular remodeling><age reversal><aging associated><aging related><aging reversal><alleviate age related><alleviate aging><ameliorating aging><arterial stiffening><arterial stiffness><artery stiffening><artery stiffness><cardiac failure><cardiovascular disorder><cardiovascular effects><circulatory system><cofilin><cohort><counter age related><counter aging><counteract age related><counteract aging><depolymerization><design><designing><determine efficacy><developmental><diabetes><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy testing><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><gain of function><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><glycogen synthase a kinase><hydroxyalkyl protein kinase><in vivo><loss of function><male><mortality><mouse model><murine model><older adult><older adulthood><older groups><older individuals><older person><pathway><pharmacologic><phosphorylase b kinase kinase><polymer><polymeric><polymerization><prevent><preventing><randomized placebo-controlled clinical trial><renal><reverse age><reverse aging><reverse aging effects><reversible aging><rho><social role><symporter><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><vascular><vasculature aging><♀><♂>

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Jaume Padilla

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$603,556

FY 2026

Project Title

SGLT2 inhibition as a therapeutic strategy to reverse arterial stiffening in aging

Grant Number:

5R01AG082413-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is the main cause of death in older adults in the US and the burden of aging- associated CVD is expected to grow as the percentage of the older population steadily grows. A key characteristic of vascular aging is arterial stiffening, which is a c...

Research Terms

<ATP-protein phosphotransferase><Actin Filaments><Actins><Address><Age Years><Aging><Arteries><Blood Vessels><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cause of Death><Cell-Extracellular Matrix><Characteristics><Clinical Trials><Co-Transporters><Collagen><D-Glucose><Dephosphorylation><Deposit><Deposition><Development><Dextrose><Diabetes Mellitus><Down-Regulation><Drugs><ECM><Event><Extracellular Matrix><F-Actin><Family member><Female><Filamentous Actin><GeneHomolog><Glucose><Goals><Heart Vascular><Heart failure><Homolog><Homologous Gene><Homologue><Kidney><Kidney Urinary System><Kinase Family Gene><Knowledge><LIM Domain Kinase 1><LIM kinase><LIMK protein><LIMK-1><Leiomyocyte><Mediating><Medication><Microfilaments><Molecular><Monomeric G-Proteins><Monomeric GTP-Binding Proteins><Morbidity><Myofilaments><Na element><Older Population><Pathogenesis><Pathway interactions><Patients><Pharmaceutical Preparations><Phosphorylation><Polymers><Protein Dephosphorylation><Protein Kinase><Protein Phosphorylation><Publishing><Reducing Agents><Reductants><Research><Role><SGLT 2 inhibitor><SGLT2i><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Sodium><Sodium glucose co-transporter 2 inhibitor><Stress Fibers><Testing><Therapeutic><Time><Vascular Smooth Muscle><Vascular aging><Vascular remodeling><age reversal><aging associated><aging related><aging reversal><alleviate age related><alleviate aging><ameliorating aging><arterial stiffening><arterial stiffness><artery stiffening><artery stiffness><cardiac failure><cardiovascular disorder><cardiovascular effects><circulatory system><cofilin><cohort><counter age related><counter aging><counteract age related><counteract aging><depolymerization><design><designing><determine efficacy><developmental><diabetes><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy testing><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><gain of function><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><glycogen synthase a kinase><hydroxyalkyl protein kinase><in vivo><loss of function><male><mortality><mouse model><murine model><older adult><older adulthood><older groups><older individuals><older person><pathway><pharmacologic><phosphorylase b kinase kinase><polymer><polymeric><polymerization><prevent><preventing><randomized placebo-controlled clinical trial><renal><reverse age><reverse aging><reverse aging effects><reversible aging><rho><social role><symporter><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><vascular><vasculature aging><♀><♂>

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Zhongjie Sun

UNIVERSITY OF TENNESSEE HEALTH SCI CTR, MEMPHIS, TN

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$602,975

FY 2026

Project Title

Regulation of kidney function and blood pressure in aging

Grant Number:

5R01DK138872-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary The incidence of kidney dysfunction and hypertension increases with age. The prevalence of chronic kidney disease (CKD) and hypertension is higher in the aged than in the young population. Salt sensitivity is more prevalent in the elderly population. The aging-associated salt sensiti...

Research Terms

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CAROL A EVERSON

MEDICAL COLLEGE OF WISCONSIN, MILWAUKEE, WI

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$601,313

FY 2026

Project Title

Chronic sleep deficiency as a cause of bone loss in aging

Grant Number:

5R01AG083653-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

More than 35% of adults in the U.S. undergo chronic sleep restriction (SR) which is associated with multiple, incompletely understood adverse health outcomes. Chronic SR is increasingly recognized as a risk factor for bone loss, bone fractures, and osteoporosis. Night shift work and chronic SR in mi...

Research Terms

<21+ years old><Acceleration><Address><Adrenal Cortex Hormones><Adrenergic Agents><Adrenergic Drugs><Adrenergics><Adult><Adult Human><Affect><Age><Aging><Animal Model><Animal Models and Related Studies><Awareness><Biological><Biology><Bone Density><Bone Diseases><Bone Formation><Bone Mineral Density><Bone Resorption><Bone remodeling><Bone structure><Bundle Bone><Calories><Cancellous bone><Causality><Cessation of life><Chronic><Circadian Rhythms><Clinical><Common Rat Strains><Contralateral><Corticoids><Corticosteroids><Data><Death><Deterioration><Disease><Disorder><Environmental Exposure><Epidemiology><Etiology><Female><Foundations><Fracture><Glucose Intolerance><Goals><Groups at risk><Health><Hindlimb><Hormonal><Human><Immature Bone><Impairment><Intermediary Metabolism><Intervention><Knowledge><Lamellar Bone><Life><Mature Bone><Mediating><Medical><Metabolic Processes><Metabolism><Modeling><Modern Man><Molecular><Morbidity><Nonlamellar Bone><Nyctohemeral Rhythm><Operative Procedures><Operative Surgical Procedures><Osteoclastic Bone Loss><Osteogenesis><Osteopenia><Osteoporosis><Osteoporotic><Outcome><Pathogenesis><Pathology><Pattern><People at risk><Persons at risk><Phenotype><Populations at Risk><Process><Public Health><Rat><Rats Mammals><Rattus><Research><Risk Factors><Role><Science><Serum Markers><Site><Skeleton><Sleep><Sleep Deprivation><Surgical><Surgical Interventions><Surgical Procedure><Survey Instrument><Surveys><Sympathectomy><Sympathetic Denervation><Sympathetic Nervous System><Testing><Time><Translational Research><Translational Science><Twenty-Four Hour Rhythm><Vertebrae><Vertebral><Woman><Work><Woven Bone><adulthood><age associated><age associated alterations><age associated changes><age associated disease><age associated disorder><age associated impairment><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent disease><age dependent disorder><age dependent impairment><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related human disease><age specific><age specific alterations><age specific changes><age-related disease><age-related disorder><age-related impairment><aged><ages><aging associated alterations><aging associated changes><aging associated disease><aging associated disorders><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related disease><aging related disorders><aging specific alterations><aging specific changes><alterations with age><antagonism><antagonist><beta-adrenergic receptor><biologic><biomechanical analyses><biomechanical analysis><biomechanical assessment><biomechanical characterization><biomechanical evaluation><biomechanical measurement><biomechanical profiling><biomechanical test><bone><bone cell><bone disorder><bone fracture><bone fragility><bone health><bone loss><bone mass><bone metabolism><bone quality><bone tissue formation><bone turnover><calorie><cardiovascular risk><cardiovascular risk factor><causation><changes with age><circadian><circadian process><circadian rhythmicity><clinical research site><clinical site><cohort><comparative><daily biorhythm><day shift><deficient sleep><disability><disease associated with aging><disease causation><disease of aging><disease risk><disorder of aging><disorder risk><disorders associated with aging><disorders related to aging><epidemiologic><epidemiological><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fracture risk><improved><in vivo><inadequate sleep><innervation><innovate><innovation><innovative><insight><insufficient sleep><later in life><later life><life span><lifespan><male><mechanical load><meeting><meetings><men><mid life><mid-life><middle age><middle aged><midlife><model of animal><nerve supply><neural><night shift><night work><novel><older adult><older adulthood><premature><prematurity><repair><repaired><response><sex dimorphism><sexual dimorphism><sexually dimorphic><shift work><shiftwork><skeletal><skeletal structure><skeletons><sleep amount><sleep debt><sleep deficiency><sleep deficit><sleep duration><sleep episode><sleep insufficiency><sleep interval><sleep length><sleep loss><sleep period><sleep quantity><sleep time><social role><spine bone structure><substantia spongiosa><substantia trabecularis><surgery><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><trabecular bone><translation research><translational investigation><β-adrenergic receptor><♀><♂>

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Jeffrey Michael Toth

MEDICAL COLLEGE OF WISCONSIN, MILWAUKEE, WI

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$601,313

FY 2026

Project Title

Chronic sleep deficiency as a cause of bone loss in aging

Grant Number:

5R01AG083653-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

More than 35% of adults in the U.S. undergo chronic sleep restriction (SR) which is associated with multiple, incompletely understood adverse health outcomes. Chronic SR is increasingly recognized as a risk factor for bone loss, bone fractures, and osteoporosis. Night shift work and chronic SR in mi...

Research Terms

<21+ years old><Acceleration><Address><Adrenal Cortex Hormones><Adrenergic Agents><Adrenergic Drugs><Adrenergics><Adult><Adult Human><Affect><Age><Aging><Animal Model><Animal Models and Related Studies><Awareness><Biological><Biology><Bone Density><Bone Diseases><Bone Formation><Bone Mineral Density><Bone Resorption><Bone remodeling><Bone structure><Bundle Bone><Calories><Cancellous bone><Causality><Cessation of life><Chronic><Circadian Rhythms><Clinical><Common Rat Strains><Contralateral><Corticoids><Corticosteroids><Data><Death><Deterioration><Disease><Disorder><Environmental Exposure><Epidemiology><Etiology><Female><Foundations><Fracture><Glucose Intolerance><Goals><Groups at risk><Health><Hindlimb><Hormonal><Human><Immature Bone><Impairment><Intermediary Metabolism><Intervention><Knowledge><Lamellar Bone><Life><Mature Bone><Mediating><Medical><Metabolic Processes><Metabolism><Modeling><Modern Man><Molecular><Morbidity><Nonlamellar Bone><Nyctohemeral Rhythm><Operative Procedures><Operative Surgical Procedures><Osteoclastic Bone Loss><Osteogenesis><Osteopenia><Osteoporosis><Osteoporotic><Outcome><Pathogenesis><Pathology><Pattern><People at risk><Persons at risk><Phenotype><Populations at Risk><Process><Public Health><Rat><Rats Mammals><Rattus><Research><Risk Factors><Role><Science><Serum Markers><Site><Skeleton><Sleep><Sleep Deprivation><Surgical><Surgical Interventions><Surgical Procedure><Survey Instrument><Surveys><Sympathectomy><Sympathetic Denervation><Sympathetic Nervous System><Testing><Time><Translational Research><Translational Science><Twenty-Four Hour Rhythm><Vertebrae><Vertebral><Woman><Work><Woven Bone><adulthood><age associated><age associated alterations><age associated changes><age associated disease><age associated disorder><age associated impairment><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent disease><age dependent disorder><age dependent impairment><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related human disease><age specific><age specific alterations><age specific changes><age-related disease><age-related disorder><age-related impairment><aged><ages><aging associated alterations><aging associated changes><aging associated disease><aging associated disorders><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related disease><aging related disorders><aging specific alterations><aging specific changes><alterations with age><antagonism><antagonist><beta-adrenergic receptor><biologic><biomechanical analyses><biomechanical analysis><biomechanical assessment><biomechanical characterization><biomechanical evaluation><biomechanical measurement><biomechanical profiling><biomechanical test><bone><bone cell><bone disorder><bone fracture><bone fragility><bone health><bone loss><bone mass><bone metabolism><bone quality><bone tissue formation><bone turnover><calorie><cardiovascular risk><cardiovascular risk factor><causation><changes with age><circadian><circadian process><circadian rhythmicity><clinical research site><clinical site><cohort><comparative><daily biorhythm><day shift><deficient sleep><disability><disease associated with aging><disease causation><disease of aging><disease risk><disorder of aging><disorder risk><disorders associated with aging><disorders related to aging><epidemiologic><epidemiological><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><fracture risk><improved><in vivo><inadequate sleep><innervation><innovate><innovation><innovative><insight><insufficient sleep><later in life><later life><life span><lifespan><male><mechanical load><meeting><meetings><men><mid life><mid-life><middle age><middle aged><midlife><model of animal><nerve supply><neural><night shift><night work><novel><older adult><older adulthood><premature><prematurity><repair><repaired><response><sex dimorphism><sexual dimorphism><sexually dimorphic><shift work><shiftwork><skeletal><skeletal structure><skeletons><sleep amount><sleep debt><sleep deficiency><sleep deficit><sleep duration><sleep episode><sleep insufficiency><sleep interval><sleep length><sleep loss><sleep period><sleep quantity><sleep time><social role><spine bone structure><substantia spongiosa><substantia trabecularis><surgery><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><trabecular bone><translation research><translational investigation><β-adrenergic receptor><♀><♂>

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Cornelia M. Weyand

MAYO CLINIC ROCHESTER, ROCHESTER, MN

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Recent

Active award

$581,040

FY 2026

Project Title

Mitochondrial Malfunction in T Cell Aging and Tissue Inflammation

Grant Number:

5U01AI179609-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Advanced age renders humans susceptible to cancer, fatal infection, neurodegeneration and cardiovascular disease. Age-related immunodeficiency combines loss of protective immunity with gain in tissue inflammation, indicating the complex restructuring of the innate and adaptive immune...

Research Terms

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Eric J Belin de Chantemele

AUGUSTA UNIVERSITY, AUGUSTA, GA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$576,322

FY 2026

Project Title

Novel mechanisms of muscle and bone loss with HIV infection, antiretroviral therapy, and aging.

Grant Number:

5R01AR082307-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Our proposal is in direct response to the special Funding Opportunity Announcement (FOA) PAR-21-068 “Multidisciplinary Studies of HIV/AIDS and Aging (R01)”. A frailty phenotype is frequently observed in HIV patients on long term antiretroviral therapy (ART), and both osteoporosis and sarcopenia are ...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><AH Receptors><AIDS Virus><AIDS/HIV><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Age><Age Months><Age related pathologies><Age-Related Bone Loss><Aging><Anabolism><Animal Model><Animal Models and Related Studies><Anti-Retroviral Agents><Aryl Hydrocarbon Receptor><Attenuated><Automobile Driving><BM Stem Cell><BM derived progenitor><BM progenitor><BM- derived Stem Cells><Body Tissues><Bone Formation><Bone Marrow><Bone Marrow Cell Transplantation><Bone Marrow Reticuloendothelial System><Bone Marrow Stem Cell><Bone Marrow progenitor><Bone Resorption><Cancellous bone><Catabolism><Cell Aging><Cell Senescence><Cell Senescence Induction><Cellular Aging><Cellular Senescence><Data><Development><Diagnosis><Dioxin Receptors><Disease Outcome><Disease Progression><Drug Therapy><Dysfunction><Enzyme Induction><Fracture><Functional disorder><Funding Opportunities><Future><Gait speed><Genes><Goals><Grip strength><HIV><HIV Infections><HIV in patients><HIV individuals><HIV infected individuals><HIV infected persons><HIV patient><HIV people><HIV positive individuals><HIV positive patient><HIV positive people><HIV viral infection><HIV virus infection><HIV-1><HIV-1 infection><HIV-I><HIV/AIDS><HIV1><Hand Strength><Health><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Human immunodeficiency virus infected patients><Human immunodeficiency virus positive patients><IDOase><In Vitro><In vivo analysis><Indoleamine 2,3-Dioxygenase><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Inflammation><Inflammatory><Knock-out><Knockout><Knowledge><Kynurenine><L-Tryptophan><LAV-HTLV-III><Leanness><Levotryptophan><Lymphadenopathy-Associated Virus><Measures><Methylation><Mice><Mice Mammals><Molecular><Murine><Mus><Muscle><Muscle Atrophy><Muscle Cells><Muscle Tissue><Muscular Atrophy><Musculoskeletal><Myocytes><Nuclear><Nuclear Translocator><Older Population><Osteoclastic Bone Loss><Osteogenesis><Osteoporosis><Outcome><Oxidative Stress><PLWH><PWH><Pathway interactions><Patients living with HIV><Patients suffering from HIV><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiopathology><Play><Polyaromatic Hydrocarbon Receptors><Progenitor Cells><Public Health><QOL><Quality of life><Receptor Activation><Replicative Senescence><Resistance><Role><Signal Pathway><Skeletal Muscle><Skeletal bone><TCDD Receptors><Testing><Thinness><Time><Tissues><Transgenic Mice><Tryptophan><Tryptophan 2,3 Dioxygenase><Virus-HIV><Voluntary Muscle><Wild Type Mouse><age associated pathologies><age dependent pathologies><age induced pathologies><age-associated bone loss><aged><ages><aging associated pathologies><aging dependent pathologies><aging induced pathologies><aging pathologies><aging related pathologies><ahr ligand><anti-retroviral><antiretroviral therapy><antiretroviral treatment><aryl hydrocarbon receptor ligand><attenuate><attenuates><beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine><biosynthesis><bone><bone cell><bone fracture><bone loss><bone loss with aging><bone marrow derived progenitor><bone marrow derived stem cells><bone marrow stromal cell><bone marrow stromal stem cell><bone mass><bone progenitor><bone stem cell><bone strength><bone tissue formation><cellular aging induction><cellular senescence induction><clinical practice><co-morbid><co-morbidity><comorbidity><developmental><driving><drug intervention><drug treatment><emtricitabine><experiment><experimental research><experimental study><experiments><falls><frailty><functional outcomes><human immunodeficiency virus infection><human immunodeficiency virus patient><improved><in vivo evaluation><in vivo testing><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><inhibitor><innovate><innovation><innovative><life span><lifespan><mechanical properties><model of animal><mortality><mouse model><multidisciplinary><murine model><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle progenitor><muscle progenitor cell><muscle stem cell><muscle strength><muscle wasting><muscular><myogenesis><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><older groups><older individuals><older person><overexpress><overexpression><pathophysiology><pathway><patient infected with HIV><patient population><patient with HIV><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><poor health outcome><reduced health outcome><replicative aging><resistant><response><sarcopenia><sarcopenic><senescence><senescence induction><senescent><social role><stem cells><substantia spongiosa><substantia trabecularis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><trabecular bone><tryptamine 2,3 dioxygenase><wildtype mouse><worse health outcome>

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Meghan E. McGee-Lawrence

AUGUSTA UNIVERSITY, AUGUSTA, GA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$576,322

FY 2026

Project Title

Novel mechanisms of muscle and bone loss with HIV infection, antiretroviral therapy, and aging.

Grant Number:

5R01AR082307-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Our proposal is in direct response to the special Funding Opportunity Announcement (FOA) PAR-21-068 “Multidisciplinary Studies of HIV/AIDS and Aging (R01)”. A frailty phenotype is frequently observed in HIV patients on long term antiretroviral therapy (ART), and both osteoporosis and sarcopenia are ...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><AH Receptors><AIDS Virus><AIDS/HIV><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Age><Age Months><Age related pathologies><Age-Related Bone Loss><Aging><Anabolism><Animal Model><Animal Models and Related Studies><Anti-Retroviral Agents><Aryl Hydrocarbon Receptor><Attenuated><Automobile Driving><BM Stem Cell><BM derived progenitor><BM progenitor><BM- derived Stem Cells><Body Tissues><Bone Formation><Bone Marrow><Bone Marrow Cell Transplantation><Bone Marrow Reticuloendothelial System><Bone Marrow Stem Cell><Bone Marrow progenitor><Bone Resorption><Cancellous bone><Catabolism><Cell Aging><Cell Senescence><Cell Senescence Induction><Cellular Aging><Cellular Senescence><Data><Development><Diagnosis><Dioxin Receptors><Disease Outcome><Disease Progression><Drug Therapy><Dysfunction><Enzyme Induction><Fracture><Functional disorder><Funding Opportunities><Future><Gait speed><Genes><Goals><Grip strength><HIV><HIV Infections><HIV in patients><HIV individuals><HIV infected individuals><HIV infected persons><HIV patient><HIV people><HIV positive individuals><HIV positive patient><HIV positive people><HIV viral infection><HIV virus infection><HIV-1><HIV-1 infection><HIV-I><HIV/AIDS><HIV1><Hand Strength><Health><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Human immunodeficiency virus infected patients><Human immunodeficiency virus positive patients><IDOase><In Vitro><In vivo analysis><Indoleamine 2,3-Dioxygenase><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Inflammation><Inflammatory><Knock-out><Knockout><Knowledge><Kynurenine><L-Tryptophan><LAV-HTLV-III><Leanness><Levotryptophan><Lymphadenopathy-Associated Virus><Measures><Methylation><Mice><Mice Mammals><Molecular><Murine><Mus><Muscle><Muscle Atrophy><Muscle Cells><Muscle Tissue><Muscular Atrophy><Musculoskeletal><Myocytes><Nuclear><Nuclear Translocator><Older Population><Osteoclastic Bone Loss><Osteogenesis><Osteoporosis><Outcome><Oxidative Stress><PLWH><PWH><Pathway interactions><Patients living with HIV><Patients suffering from HIV><Pharmacological Treatment><Pharmacotherapy><Phenotype><Physiopathology><Play><Polyaromatic Hydrocarbon Receptors><Progenitor Cells><Public Health><QOL><Quality of life><Receptor Activation><Replicative Senescence><Resistance><Role><Signal Pathway><Skeletal Muscle><Skeletal bone><TCDD Receptors><Testing><Thinness><Time><Tissues><Transgenic Mice><Tryptophan><Tryptophan 2,3 Dioxygenase><Virus-HIV><Voluntary Muscle><Wild Type Mouse><age associated pathologies><age dependent pathologies><age induced pathologies><age-associated bone loss><aged><ages><aging associated pathologies><aging dependent pathologies><aging induced pathologies><aging pathologies><aging related pathologies><ahr ligand><anti-retroviral><antiretroviral therapy><antiretroviral treatment><aryl hydrocarbon receptor ligand><attenuate><attenuates><beta-L-2',3'-dideoxy-5-fluoro-3'-thiacytidine><biosynthesis><bone><bone cell><bone fracture><bone loss><bone loss with aging><bone marrow derived progenitor><bone marrow derived stem cells><bone marrow stromal cell><bone marrow stromal stem cell><bone mass><bone progenitor><bone stem cell><bone strength><bone tissue formation><cellular aging induction><cellular senescence induction><clinical practice><co-morbid><co-morbidity><comorbidity><developmental><driving><drug intervention><drug treatment><emtricitabine><experiment><experimental research><experimental study><experiments><falls><frailty><functional outcomes><human immunodeficiency virus infection><human immunodeficiency virus patient><improved><in vivo evaluation><in vivo testing><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><inhibitor><innovate><innovation><innovative><life span><lifespan><mechanical properties><model of animal><mortality><mouse model><multidisciplinary><murine model><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle progenitor><muscle progenitor cell><muscle stem cell><muscle strength><muscle wasting><muscular><myogenesis><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><older groups><older individuals><older person><overexpress><overexpression><pathophysiology><pathway><patient infected with HIV><patient population><patient with HIV><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><poor health outcome><reduced health outcome><replicative aging><resistant><response><sarcopenia><sarcopenic><senescence><senescence induction><senescent><social role><stem cells><substantia spongiosa><substantia trabecularis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><trabecular bone><tryptamine 2,3 dioxygenase><wildtype mouse><worse health outcome>

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Raghavan Pillai Raju

AUGUSTA UNIVERSITY, AUGUSTA, GA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$558,872

FY 2026

Project Title

Reparative effect of juvenile factors in aging and injury

Grant Number:

5R01AG073338-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Aging and injury are among the major global health problems and death due to injury increases sharply with age. As hemorrhage accounts for almost half of all trauma-related deaths, there is a need to develop methods to reduce the adverse effects of aging on injury to facilitate healthy living. In th...

Research Terms

<21+ years old><AD dementia><AD model><AD pathology><Acute><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Adverse effects><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's pathology><Alzheimers Dementia><Antioxidants><Autophagocytosis><Biologic Models><Biological><Biological Models><Biology of Aging><Bleeding><Blood Plasma><Cell Body><Cells><Cessation of life><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Comment><Commentary><Data><Death><Degenerative Neurologic Disorders><Deterioration><Development><Differences between sexes><Differs between sexes><Disturbance in cognition><Dysfunction><Editorial Comment><Elderly><Equilibrium><Exhibits><Experimental Models><Functional disorder><Gene Expression><Genes><Goals><Heart><Hemorrhage><Hemorrhagic Shock><Hypoxia><Hypoxic><Impaired cognition><Injury><Intestinal><Intestines><Knowledge><Liver><Lung><Lung Respiratory System><Methods><Mice><Mice Mammals><MicroRNAs><Mission><Mitochondria><Model System><Modeling><Molecular><Morbidity><Murine><Mus><NIH><National Institutes of Health><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Organ><Outcome><Outcomes Research><Oxidative Stress><Oxygen Deficiency><Pathology><Pathway interactions><Patients><Physiopathology><Plasma><Plasma Serum><Primary Senile Degenerative Dementia><Published Comment><Research><Reticuloendothelial System, Serum, Plasma><Role><SIRT1><SIRT1 gene><Sex Differences><Sex Maturation><Sexual Maturation><Sexual differences><Sirtuin 1><System><Techniques><Testing><Therapeutic><Time><Trauma><Traumatic injury><United States National Institutes of Health><Viewpoint><adult animal><adulthood><advanced age><advanced age rats><age associated><age associated alterations><age associated changes><age associated disease><age associated disorder><age associated effects><age associated impairment><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent disease><age dependent disorder><age dependent impairment><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age effect><age group><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related effects><age related human disease><age related neurodegeneration><age specific><age specific alterations><age specific changes><age-driven neurodegenerative disorders><age-related disease><age-related disorder><age-related impairment><age-related neurodegenerative disease><age-related neurodegenerative disorder><aged animal><aged animals><aged mice><aged mouse><aged rat><aged rats><ages><aging associated alterations><aging associated changes><aging associated neurodegeneration><aging associated neurodegenerative disease><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><aging specific alterations><aging specific changes><alterations with age><alzheimer model><animal old age><autophagy><balance><balance function><biochemical tools><biochemistry tools><biologic><blood loss><bowel><changes with age><co-morbid><co-morbidity><cognitive dysfunction><cognitive function><cognitive loss><comorbidity><decline in function><decline in functional status><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><disease model><disorder model><effective therapy><effective treatment><elderly animal><elderly mice><elderly patient><elderly rats><exosome><experiment><experimental research><experimental study><experiments><extracellular vesicles><functional decline><functional status decline><genomic tools><geriatric><geriatric rats><global health><hepatic body system><hepatic organ system><high risk><human disease><impact of age><improved><improved outcome><influence of age><injuries><juvenile><juvenile animal><juvenile human><life span><lifespan><mature animal><miRNA><mitochondrial><mitochondrial dysfunction><mortality><mouse model><murine model><neurodegenerative illness><old age><old animals><old mice><old rats><older patient><pathophysiology><pathway><primary degenerative dementia><profound disability><protective effect><protective factors><resilience><resilient><response><senile dementia of the Alzheimer type><senior citizen><serious disability><severe disability><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><young animal>

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Hadi Hosseini

STANFORD UNIVERSITY, STANFORD, CA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$548,426

FY 2026

Project Title

Interactive Effects of Aging and AD on Brain Networks

Grant Number:

5R01AG072470-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Among the known risk factors for late-onset AD, age is considered the greatest. After age of 65, the risk of developing AD doubles every five years. While there is a consensus that late-onset AD mainly impacts the aging brain, the direct effects of aging on development and progressio...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD dementia><AD model><AD pathology><AD risk><AD risk factor><Acceleration><Adult><Adult Human><Affect><Age><Aged 65 and Over><Aging><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's disease therapeutic><Alzheimer's pathology><Alzheimer's therapeutic><Alzheimers Dementia><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Experimental Use><Animal Experimentation><Animal Research><Aβ><Body Tissues><Brain><Brain Nervous System><Brain imaging><Brain region><Cell Communication and Signaling><Cell Signaling><Clinical><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Compensation><Consensus><Data><Data Set><Development><Diagnosis><Diffusion><Disease Outcome><Disturbance in cognition><Encephalon><Generalized Growth><Goals><Growth><Human><Impaired cognition><Inflammation><Intracellular Communication and Signaling><Knowledge><Late Onset Alzheimer Disease><Late onset AD><Lipids><MR Imaging><MR Tomography><MRI><MRI biomarker><MRI marker><MRIs><MT-bound tau><Magnetic Resonance Imaging><Measurement><Measures><Medial><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Memory Loss><Methods><Modeling><Modern Man><Morphology><Myelin><NMR Imaging><NMR Tomography><Neurites><Neurosciences><Non-linear Models><Nonlinear Models><Nuclear Magnetic Resonance Imaging><Organizational Change><PET><PET Scan><PET imaging><PETSCAN><PETT><Parietal><Patients><Phenotype><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Process><Property><Rad.-PET><Reporting><Research Priority><Research Resources><Resources><Rest><Risk Factors><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Structure><Synapses><Synaptic><Techniques><Testing><Tissue Growth><Tissues><Vascular Diseases><Vascular Disorder><Zeugmatography><a beta peptide><abeta><above age 65><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age associated alterations><age associated changes><age associated effects><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age effect><age induced alterations><age induced changes><age linked><age of 65 years onward><age related><age related alterations><age related changes><age related effects><age related pathways><age specific><age specific alterations><age specific changes><aged 65 and greater><aged 65+><aged brain><aged ≥65><ages><aging associated alterations><aging associated changes><aging associated mechanism><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging mechanism><aging pathway><aging related alterations><aging related changes><aging related mechanism><aging related pathways><aging specific alterations><aging specific changes><alterations with age><alzheimer model><alzheimer risk><amnestic mild cognitive impairment><amyloid beta><amyloid pathology><amyloid-b protein><animal experimentations><anti aging based therapeutic><anti aging therapeutic><anti-aging property therapeutic><beta amyloid fibril><biological mechanism of age><biological pathways of age><biological signal transduction><biomarker development><blood vessel disorder><brain visualization><changes with age><cognitive dysfunction><cognitive loss><cohort><compare effectiveness><connectome><density><developmental><diffused><diffuses><diffusing><diffusions><disease phenotype><geroscience therapeutic><gerotherapeutic><gray matter><human old age (65+)><impact of age><improved><in vivo><indexing><influence of age><late onset alzheimer><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><magnetic resonance imaging biomarker><magnetic resonance imaging marker><mechanism regulating aging><mechanisms involved in aging><memory decline><microtubule bound tau><microtubule-bound tau><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><mitochondrial dysfunction><natural aging><neural><neural circuit><neural circuitry><neural imaging><neural network><neuro-imaging><neurocircuitry><neuroimaging><neurological imaging><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><normal aging><normative aging><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><older adult><older adulthood><ontogeny><over 65 years><pathway involved in aging><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><preclinical><primary degenerative dementia><response><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><soluble amyloid precursor protein><substantia alba><substantia grisea><synapse><synaptic circuit><synaptic circuitry><tau><tau Proteins><tau factor><therapeutic against aging><therapeutic interventions against aging><therapeutic strategies for aging><therapeutic strategies targeting aging><therapeutic target for anti-aging><therapeutic targeting aging><therapeutic targets to reverse aging><therapeutic to prevent aging><therapeutics impacts on aging><therapeutics that slow aging><vascular dysfunction><vasculopathy><white matter><τ Proteins><≥65 years>

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Alison J Scott

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$546,222

FY 2026

Project Title

Defining lipid droplet homeostasis in Alzheimer's disease and aging with high molecular specificity using mass spectrometry imaging and isomer resolved lipidomics

Grant Number:

5R01AG081436-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY Loss of healthspan - declining health and function as we age – impacts nearly every living organism and is a pronounced feature of Alzheimer’s disease and related dementias (ADRD), affecting nearly 6 million people in the United States. Lipids are poorly understood central components of agin...

Research Terms

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JILL M DANIEL

TULANE UNIVERSITY OF LOUISIANA, NEW ORLEANS, LA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$534,026

FY 2026

Project Title

Short-term estradiol use in middle-age: implications for female cognitive aging

Grant Number:

5R01AG041374-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2012

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary Loss of ovarian hormones during menopause coincides with cognitive decline and increased risk of Alzheimer's disease and related dementias. Due to putative health risks associated with prolonged exposure to estrogens, current guidelines recommend limiting hormone therapy to a few years to tr...

Research Terms

<1-Phosphatidylinositol 3-Kinase><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Ammon Horn><Aquadiol><Attenuated><Award><Benign senescent forgetfulness><Brain><Brain Nervous System><Cell Communication and Signaling><Cell Signaling><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Data><Dimenformon><Diogyn><Diogynets><Disturbance in cognition><ERalpha><ERα><ESR1><ESR1 gene><Encephalon><Endocrine Gland Secretion><Endocrine Therapy><Estrace><Estradiol><Estradiol Receptor alpha><Estradiol Receptor α><Estradiol-17 beta><Estradiol-17beta><Estraldine><Estrogen Receptor 1><Estrogen Receptor alpha><Estrogen Receptor α><Estrogen Therapy><Estrogen decline><Estrogens><Exposure to><Extracellular Signal-Regulated Kinase Gene><Female><Female Health><Gene Transcription><Genes><Genetic Transcription><Goals><Guidelines><Health><Hippocampus><History><Hormonal Therapy><Hormones><Human><IGF-1><IGF-I><IGF-I-SmC><Impaired cognition><Incidence><Insulin homeostasis><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Intervention><Intracellular Communication and Signaling><Ligands><Long-Term Effects><MAP Kinase Gene><MAPK><MAPK Signaling Pathway><MAPK Signaling Pathway Pathway><Maintenance><Mediating><Memory><Menopausal Symptom><Menopause><Mitogen-Activated Protein Kinase Gene><Modern Man><NR3A1><Ovarian><Ovarian hormone><Ovocyclin><Ovocylin><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><Pathway interactions><Pattern><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Population><Post-Menopause><Post-menopausal Period><Postmenopausal Period><Postmenopause><Primary Senile Degenerative Dementia><Progynon><Proteins><PtdIns 3-Kinase><Public Health><RNA Expression><Recommendation><Recording of previous events><Regulation><Research><Risk><Rodent Model><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Site><Somatomedin C><Testing><Therapeutic Estradiol><Therapeutic Estrogen><Therapeutic Hormone><Time><Transcription><Transgenic Mice><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><United States><Viral Vector><Woman><Women's Health><Work><after menopause><age associated cognitive impairment><age associated dementia><age associated memory decline><age associated memory deficit><age induced dementia><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related dementia><age related memory dysfunction><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><ages><aging associated dementia><aging prevention><aging related cognitive decline><aging related dementia><alzheimer risk><anti aging><anti geronic><antiaging><attenuate><attenuates><base><bases><biological signal transduction><cognitive dysfunction><cognitive enhancement><cognitive loss><decline in estrogen><declining cognitive functions with aging><decrease estrogen><decrease in estrogen><delivery vector><delivery vehicle><deprivation><estrogen hormone therapy><estrogen treatment><estrogen-related receptor><following menopause><hippocampal><histories><hormone therapy><insulin balance><insulin control><long-term memory><mid life><mid-life><middle age><middle aged><midlife><midlife estradiol><mouse model><murine model><past menopause><pathway><pharmacologic><post-menopausal><postmenopausal><postmenopausal status><prevent><prevent age related><prevent aging><preventing><primary degenerative dementia><reduced estrogen><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social role><suppress aging><treated with estrogen><treatment with estrogen><♀>

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Zhen Yue Jiang

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$526,476

FY 2026

Project Title

Neutrophils play a pivotal role in vascular aging

Grant Number:

5R01HL168560-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/22/2023

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Arterial stiffness is a hallmark of vascular aging and is related to increased cardiovascular disease events and vascular dementias. Inflammatory damage and extracellular matrix remodeling have been proposed as the major pathological causes of vascular injury and arterial stiffness. However...

Research Terms

<4q Chemokine><Acetylation><Adhesion Molecule><Aging><Amiloride><Animals><Aorta><Arteries><Arteriosclerotic Dementia><B-Cells><B-Lymphocytes><B-cell><BMP-2><BMP-2A><BMP2><BMP2 gene><BMP2A Gene><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood Pressure><Blood Vessels><Blood leukocyte><Body Tissues><Bone Morphogenetic Protein 2 Gene><Bone Morphogenetic Protein 2A Gene><Bone-Derived Transforming Growth Factor><C-X-C Chemokines><C57BL/6 Mouse><CCN2><CTGF><CXC Chemokines><Calcified><Cardiovascular Diseases><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell-Extracellular Matrix><Cells><Chemokine Receptor Gene><Chronic><Cytoplasmic Granules><DNA Binding><DNA Binding Interaction><DNA bound><Data><Deacetylase><Development><Diet><Disease><Disorder><ECM><ENaC><Elastases><Endothelium><Esteroproteases><Event><Extracellular Matrix><Extravasation><Fats><Fatty acid glycerol esters><Female><Fibrosis><Fructose><Granulocyte Elastase><Human><IGF-binding protein-related protein-2><IGFBP-8><IGFBP-rP2><Immune><Immunes><In Vitro><Infiltration><Inflammation><Inflammatory><Injury><Intracellular Communication and Signaling><Involuntary Muscle><JV18><JV18-1><KO mice><Kinases><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Leakage><Leiomyocyte><Length of Life><Leucocytic infiltrate><Leukocyte Elastase><Leukocytes><Leukocytes Reticuloendothelial System><Levulose><Longevity><Lysosomal Elastase><MADH2><MADH2 gene><MADR2><Marrow Neutrophil><Marrow leukocyte><Measures><Medial><Mediating><Mediator><Mice><Mice Mammals><Milk Growth Factor><Modern Man><Molecular><Murine><Mus><Neutrophil Elastase><Neutrophil Infiltration><Neutrophil Recruitment><Neutrophilic Granulocyte><Neutrophilic Infiltrate><Neutrophilic Leukocyte><Nuclear Translocation><Null Mouse><Obesity><Oral><Oxidants><Oxidizing Agents><PAR-2 Receptor><PAR2 Receptor><PMN Elastase><Pathologic><Pathway interactions><Peptidases><Peptide Hydrolases><Permeability><Phenotype><Phosphotransferase Gene><Phosphotransferases><Physiologic pulse><Platelet Transforming Growth Factor><Play><Polymorphonuclear Cell><Polymorphonuclear Leukocyte Elastase><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Prevalence><Production><Protease Gene><Protease-Activated Receptor 2><Proteases><Proteinase Activated Receptor 2><Proteinases><Proteolytic Enzymes><Pulse><Regulation><Reporting><Resistance><Role><SIRT1><SIRT1 gene><SMAD2><Serine Endopeptidases><Serine Protease><Serine Protein Hydrolases><Serine Proteinases><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Sirtuin 1><Site><Smooth Muscle><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Spillage><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Testing><Therapeutic Effect><Tissues><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Transphosphorylases><Trypsin Receptor><Vascular Dementia><Vascular Endothelial Cell><Vascular Endothelium><Vascular Permeabilities><Vascular Smooth Muscle><Vascular aging><Vascular remodeling><White Blood Cells><White Cell><adiposity><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged mice><aged mouse><aging associated><aging process><aging related><alpha-Chemokines><arterial stiffening><arterial stiffness><artery stiffening><artery stiffness><biological signal transduction><bone morphogenetic protein 2><calcification><cardiovascular disorder><cell adhesion protein><cerebrovascular contributions to dementia><chemokine receptor><connective tissue growth factor><corpulence><developmental><diets><elderly mice><electron acceptor><epithelial Na+ channel><epithelial sodium channel><feeding><fisp12 protein><granule><in vivo><injuries><injury to the vasculature><injury to tissue><insulin-like growth factor binding protein 8><life span><lifespan><male><migration><mouse model><murine model><neutrophil><neutrophil elastase inhibitor><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><obesity-promoting diet><obesogenic Western-style diet><obesogenic diet><obesogenic high fat diet><obesogenic western diet><old mice><osteogenic><pathway><pro-obesity diet><progenitor><protective effect><resistant><social role><tissue injury><vascular><vascular contributions in dementia><vascular contributions to dementia><vascular endothelium permeability><vascular injury><vascular related dementia><vasculature aging><white blood cell><white blood corpuscle><♀><♂>

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Gordon Joseph Berman

GEORGIA INSTITUTE OF TECHNOLOGY, ATLANTA, GA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$518,133

FY 2026

Project Title

Inferring multi-scale dynamics underlying behavior in aging C. elegans

Grant Number:

5R01AG082039-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Physiological processes such as aging must arise from activities and events spanning multiple time scales. Although important, the dynamics of these processes are difficult to measure and study. In multicellular model organisms for aging, the freely living nematode C. elegans is amo...

Research Terms

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Hang Lu

GEORGIA INSTITUTE OF TECHNOLOGY, ATLANTA, GA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$518,133

FY 2026

Project Title

Inferring multi-scale dynamics underlying behavior in aging C. elegans

Grant Number:

5R01AG082039-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Physiological processes such as aging must arise from activities and events spanning multiple time scales. Although important, the dynamics of these processes are difficult to measure and study. In multicellular model organisms for aging, the freely living nematode C. elegans is amo...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Carrie Dow-Smith

UNIVERSITY OF WASHINGTON, SEATTLE, WA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$514,902

FY 2026

Project Title

The impact of stress and caregiver sensitivity on infant cellular aging in a population of under-resourced families: A randomized controlled trial.

Grant Number:

5R01NR021020-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/14/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. MODIFIED TITLE: The impact of early experiences and parent sensitivity on infant cellular aging: A randomized controlled trial. Modified Project Summary The aim of the...

Research Terms

<0-11 years old><Acceleration><Accessory Sinuses><Accounting><Active Follow-up><Address><Aeroseb-HC><Age><Aging><Biological><Blood><Blood Reticuloendothelial System><Buffers><Care Givers><Caregivers><Caring><Cell Aging><Cell Senescence><Cell division><Cellular Aging><Cellular Senescence><Cessation of life><Cetacort><Child><Child Behavior><Child Rearing><Child Youth><Childhood><Children (0-21)><Chromosomes><Conceptions><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Death><Dermacort><Development><Disease><Disorder><Dryness><Early Intervention><Eldecort><Emotional><Enrollment><Epigenetic age><Exposure to><Family><GrimAge clock><Hannum clock><Health><Heritability><Home visitation><Horvath clock><House Call><Hydrocortisone><Hydrocortone><Hytone><ImProv><Infant><Intervention><Knowledge><Length><Life><Life Experience><Literature><Measures><Mediating><Mediation><Methylation><Modeling><Morbidity><Nasal Sinuses><Nasal cavity/Paranasal><Nasal cavity/Paranasal sinuses><Negotiating><Negotiation><North Carolina><Nutracort><Outcome><Paranasal Sinuses><Parental Ages><Parenting><Parenting behavior><Parents><Patients><Perinatal><Peripartum><PhenoAge clocks><Population><Predisposition><Primary Care><Process><Proctocort><Provider><Public Health><Randomized><Randomized, Controlled Trials><Recommendation><Replicative Senescence><Research Resources><Resources><Risk><Sampling><Science><Shapes><Sinus><Spottings><Stress><Structure><Susceptibility><Telomere Shortening><Testing><Text><Well Child Visits><Well child checks><Well child checkups><Well child exam><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><active followup><age clock><ages><aging clocks><aging induced epigenetic change><aging-associated epigenetic change><aging-related epigenetic change><assess effectiveness><biologic><care as usual><care giving><caregiving><child routine wellness visits><child wellness visit><childrearing><clock measuring biological age><clock measuring biological aging><clock of biological aging><cost><determine effectiveness><developmental><dosage><early experience><effectiveness assessment><effectiveness evaluation><emotion regulation><emotional regulation><enroll><epigenetic age clocks><epigenetic aging><epigenetic clock><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic molecular clocks><epigenetic regulation of aging><evaluate effectiveness><evidence base><examine effectiveness><experience><family support><faster epigenetic aging><faster rates of epigenetic aging><follow up><follow-up><followed up><followup><hallmarks of aging><healthy lifestyle><home visit><improved><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><innovate><innovation><innovative><integrated care><integrated health care><integrated model of care><intergenerational><kids><methylation clock><mortality><parent><patient population><pediatric><pediatric preventive visit><pediatric well visit><pillars of aging><poor health outcome><post intervention><primary care setting><programs><protective factors><randomisation><randomization><randomized control trial><randomly assigned><rapid epigenetic aging><recruit><reduced health outcome><replicative aging><respiratory><response><routine child health visit><satisfaction><social><stressor><telomere><telomere attrition><treatment as usual><treatment group><usual care><usual care arm><usual care control group><worse health outcome><youngster>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

MONICA L OXFORD

UNIVERSITY OF WASHINGTON, SEATTLE, WA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$514,902

FY 2026

Project Title

The impact of stress and caregiver sensitivity on infant cellular aging in a population of under-resourced families: A randomized controlled trial.

Grant Number:

5R01NR021020-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/14/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. MODIFIED TITLE: The impact of early experiences and parent sensitivity on infant cellular aging: A randomized controlled trial. Modified Project Summary The aim of the...

Research Terms

<0-11 years old><Acceleration><Accessory Sinuses><Accounting><Active Follow-up><Address><Aeroseb-HC><Age><Aging><Biological><Blood><Blood Reticuloendothelial System><Buffers><Care Givers><Caregivers><Caring><Cell Aging><Cell Senescence><Cell division><Cellular Aging><Cellular Senescence><Cessation of life><Cetacort><Child><Child Behavior><Child Rearing><Child Youth><Childhood><Children (0-21)><Chromosomes><Conceptions><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Death><Dermacort><Development><Disease><Disorder><Dryness><Early Intervention><Eldecort><Emotional><Enrollment><Epigenetic age><Exposure to><Family><GrimAge clock><Hannum clock><Health><Heritability><Home visitation><Horvath clock><House Call><Hydrocortisone><Hydrocortone><Hytone><ImProv><Infant><Intervention><Knowledge><Length><Life><Life Experience><Literature><Measures><Mediating><Mediation><Methylation><Modeling><Morbidity><Nasal Sinuses><Nasal cavity/Paranasal><Nasal cavity/Paranasal sinuses><Negotiating><Negotiation><North Carolina><Nutracort><Outcome><Paranasal Sinuses><Parental Ages><Parenting><Parenting behavior><Parents><Patients><Perinatal><Peripartum><PhenoAge clocks><Population><Predisposition><Primary Care><Process><Proctocort><Provider><Public Health><Randomized><Randomized, Controlled Trials><Recommendation><Replicative Senescence><Research Resources><Resources><Risk><Sampling><Science><Shapes><Sinus><Spottings><Stress><Structure><Susceptibility><Telomere Shortening><Testing><Text><Well Child Visits><Well child checks><Well child checkups><Well child exam><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><active followup><age clock><ages><aging clocks><aging induced epigenetic change><aging-associated epigenetic change><aging-related epigenetic change><assess effectiveness><biologic><care as usual><care giving><caregiving><child routine wellness visits><child wellness visit><childrearing><clock measuring biological age><clock measuring biological aging><clock of biological aging><cost><determine effectiveness><developmental><dosage><early experience><effectiveness assessment><effectiveness evaluation><emotion regulation><emotional regulation><enroll><epigenetic age clocks><epigenetic aging><epigenetic clock><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic molecular clocks><epigenetic regulation of aging><evaluate effectiveness><evidence base><examine effectiveness><experience><family support><faster epigenetic aging><faster rates of epigenetic aging><follow up><follow-up><followed up><followup><hallmarks of aging><healthy lifestyle><home visit><improved><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><innovate><innovation><innovative><integrated care><integrated health care><integrated model of care><intergenerational><kids><methylation clock><mortality><parent><patient population><pediatric><pediatric preventive visit><pediatric well visit><pillars of aging><poor health outcome><post intervention><primary care setting><programs><protective factors><randomisation><randomization><randomized control trial><randomly assigned><rapid epigenetic aging><recruit><reduced health outcome><replicative aging><respiratory><response><routine child health visit><satisfaction><social><stressor><telomere><telomere attrition><treatment as usual><treatment group><usual care><usual care arm><usual care control group><worse health outcome><youngster>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Idan Shalev

UNIVERSITY OF WASHINGTON, SEATTLE, WA

High-opportunity lead · 74/100

Likely hiring

Above-average budget

Very recent

Active award

$514,902

FY 2026

Project Title

The impact of stress and caregiver sensitivity on infant cellular aging in a population of under-resourced families: A randomized controlled trial.

Grant Number:

5R01NR021020-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/14/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Enter the text here that is the new abstract information for your application. This section must be no longer than 30 lines of text. MODIFIED TITLE: The impact of early experiences and parent sensitivity on infant cellular aging: A randomized controlled trial. Modified Project Summary The aim of the...

Research Terms

<0-11 years old><Acceleration><Accessory Sinuses><Accounting><Active Follow-up><Address><Aeroseb-HC><Age><Aging><Biological><Blood><Blood Reticuloendothelial System><Buffers><Care Givers><Caregivers><Caring><Cell Aging><Cell Senescence><Cell division><Cellular Aging><Cellular Senescence><Cessation of life><Cetacort><Child><Child Behavior><Child Rearing><Child Youth><Childhood><Children (0-21)><Chromosomes><Conceptions><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Death><Dermacort><Development><Disease><Disorder><Dryness><Early Intervention><Eldecort><Emotional><Enrollment><Epigenetic age><Exposure to><Family><GrimAge clock><Hannum clock><Health><Heritability><Home visitation><Horvath clock><House Call><Hydrocortisone><Hydrocortone><Hytone><ImProv><Infant><Intervention><Knowledge><Length><Life><Life Experience><Literature><Measures><Mediating><Mediation><Methylation><Modeling><Morbidity><Nasal Sinuses><Nasal cavity/Paranasal><Nasal cavity/Paranasal sinuses><Negotiating><Negotiation><North Carolina><Nutracort><Outcome><Paranasal Sinuses><Parental Ages><Parenting><Parenting behavior><Parents><Patients><Perinatal><Peripartum><PhenoAge clocks><Population><Predisposition><Primary Care><Process><Proctocort><Provider><Public Health><Randomized><Randomized, Controlled Trials><Recommendation><Replicative Senescence><Research Resources><Resources><Risk><Sampling><Science><Shapes><Sinus><Spottings><Stress><Structure><Susceptibility><Telomere Shortening><Testing><Text><Well Child Visits><Well child checks><Well child checkups><Well child exam><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><active followup><age clock><ages><aging clocks><aging induced epigenetic change><aging-associated epigenetic change><aging-related epigenetic change><assess effectiveness><biologic><care as usual><care giving><caregiving><child routine wellness visits><child wellness visit><childrearing><clock measuring biological age><clock measuring biological aging><clock of biological aging><cost><determine effectiveness><developmental><dosage><early experience><effectiveness assessment><effectiveness evaluation><emotion regulation><emotional regulation><enroll><epigenetic age clocks><epigenetic aging><epigenetic clock><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic molecular clocks><epigenetic regulation of aging><evaluate effectiveness><evidence base><examine effectiveness><experience><family support><faster epigenetic aging><faster rates of epigenetic aging><follow up><follow-up><followed up><followup><hallmarks of aging><healthy lifestyle><home visit><improved><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><innovate><innovation><innovative><integrated care><integrated health care><integrated model of care><intergenerational><kids><methylation clock><mortality><parent><patient population><pediatric><pediatric preventive visit><pediatric well visit><pillars of aging><poor health outcome><post intervention><primary care setting><programs><protective factors><randomisation><randomization><randomized control trial><randomly assigned><rapid epigenetic aging><recruit><reduced health outcome><replicative aging><respiratory><response><routine child health visit><satisfaction><social><stressor><telomere><telomere attrition><treatment as usual><treatment group><usual care><usual care arm><usual care control group><worse health outcome><youngster>

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Charles DeCarli

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,673,985

FY 2026

Project Title

Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease

Grant Number:

5R01AG075758-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2022

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Abstract By 2060, the CDC projects that the Latino population will experience the largest increase in Alzheimer’s disease and related dementia (ADRD) cases of all US ethnic/racial groups. The main explanation for high Latino ADRD is attributed largely to early and excess cardiovascular disease (CVD)...

Research Terms

<21+ years old><AD and related dementia><AD biological marker><AD biomarker><AD dementia><AD pathology><AD related biomarker><AD related dementia><AD risk><AD risk factor><ADRD><APOE><Address><Adult><Adult Human><Affect><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's biomarker><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's pathology><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Apo-E><ApoE protein><Apolipoprotein E><Biological><Biological Aging><Biological Markers><Biology><Blood Plasma><Blood Vessels><Brain><Brain Nervous System><Brain Vascular Trauma><California><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Censuses><Cerebrovascular Trauma><Chronic><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Country><Data><Dementia><Diabetes Mellitus><Disparate><Disparities><Disparity><Disturbance in cognition><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Ethnic Origin><Ethnicity><Exposure to><Face><Funding><Genes><Genetic><Genetic Risk><Genomics><Genotype><Goals><HCHS/SOL Study><HCHS/SOL cohort><Heart Vascular><Heterogeneity><Hispanic Community Health Study/Study of Latinos><Impaired cognition><Investigation><Knowledge><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mendelian randomization><Methods><Morbidity><NHLBI><NIAAA><NMR Imaging><NMR Tomography><National Heart, Lung, and Blood Institute><National Institute on Alcohol Abuse and Alcoholism><Nerve Degeneration><Neurocognitive><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Pathology><Plasma><Plasma Serum><Population><Population Growth><Population Heterogeneity><Preventative intervention><Primary Senile Degenerative Dementia><Public Health><Racial Group><Research><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Structure><Study of Latinos><Subgroup><Texas><Therapeutic Intervention><Training><Vascular Brain Injury><Vascular Diseases><Vascular Disorder><Visit><Zeugmatography><adulthood><aged brain><ages><aging brain><aging induced epigenetic change><aging-associated epigenetic change><aging-related epigenetic change><alzheimer risk><bilingual><bilingualism><bio-markers><biologic><biologic marker><biological process of age><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><blood vessel disorder><brain tissue><brain vascularization><burden of disease><burden of illness><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><career><cerebral vascular injury><cerebral vascularization><cerebrovascular injury><circulatory system><cognitive dysfunction><cognitive loss><cohort><conference><convention><critical period><dementia risk><diabetes><disease burden><disease phenotype><disparity in health><diverse populations><epigenetic aging><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic regulation of aging><epigenetically><ethnic difference><ethnicity difference><experience><faces><facial><health disparity><heterogeneous population><improved><intervention for prevention><intervention therapy><mid life><mid-life><middle age><middle aged><midlife><neural degeneration><neurodegeneration><neurodegenerative><neuroimaging biomarker><neuroimaging marker><neurological degeneration><neuronal degeneration><older adult><older adulthood><p-tau><p-τ><phospho-tau><phospho-τ><phosphorylated tau><polygenetic risk scores><polygenic risk score><population diversity><post-translational modification of tau><posttranslational modification of tau><prevent><preventing><prevention intervention><preventional intervention strategy><preventive intervention><primary degenerative dementia><racial population><racial subgroup><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social cultural factor><social culture><social culture determinant><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><summit><symposia><symposium><tau phosphorylation><tau posttranslational modification><tau-1><vascular><vascular contributions><vascular dysfunction><vasculopathy><τ phosphorylation>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Hector M Gonzalez

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$3,673,985

FY 2026

Project Title

Study of Latinos-Investigation of Neurocognitive Aging-Alzheimer's disease

Grant Number:

5R01AG075758-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2022

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Abstract By 2060, the CDC projects that the Latino population will experience the largest increase in Alzheimer’s disease and related dementia (ADRD) cases of all US ethnic/racial groups. The main explanation for high Latino ADRD is attributed largely to early and excess cardiovascular disease (CVD)...

Research Terms

<21+ years old><AD and related dementia><AD biological marker><AD biomarker><AD dementia><AD pathology><AD related biomarker><AD related dementia><AD risk><AD risk factor><ADRD><APOE><Address><Adult><Adult Human><Affect><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's biomarker><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease pathology><Alzheimer's disease related biomarker><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's pathology><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Apo-E><ApoE protein><Apolipoprotein E><Biological><Biological Aging><Biological Markers><Biology><Blood Plasma><Blood Vessels><Brain><Brain Nervous System><Brain Vascular Trauma><California><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Censuses><Cerebrovascular Trauma><Chronic><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Country><Data><Dementia><Diabetes Mellitus><Disparate><Disparities><Disparity><Disturbance in cognition><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Ethnic Origin><Ethnicity><Exposure to><Face><Funding><Genes><Genetic><Genetic Risk><Genomics><Genotype><Goals><HCHS/SOL Study><HCHS/SOL cohort><Heart Vascular><Heterogeneity><Hispanic Community Health Study/Study of Latinos><Impaired cognition><Investigation><Knowledge><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mendelian randomization><Methods><Morbidity><NHLBI><NIAAA><NMR Imaging><NMR Tomography><National Heart, Lung, and Blood Institute><National Institute on Alcohol Abuse and Alcoholism><Nerve Degeneration><Neurocognitive><Neuron Degeneration><Nuclear Magnetic Resonance Imaging><Pathology><Plasma><Plasma Serum><Population><Population Growth><Population Heterogeneity><Preventative intervention><Primary Senile Degenerative Dementia><Public Health><Racial Group><Research><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Structure><Study of Latinos><Subgroup><Texas><Therapeutic Intervention><Training><Vascular Brain Injury><Vascular Diseases><Vascular Disorder><Visit><Zeugmatography><adulthood><aged brain><ages><aging brain><aging induced epigenetic change><aging-associated epigenetic change><aging-related epigenetic change><alzheimer risk><bilingual><bilingualism><bio-markers><biologic><biologic marker><biological process of age><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><blood vessel disorder><brain tissue><brain vascularization><burden of disease><burden of illness><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><career><cerebral vascular injury><cerebral vascularization><cerebrovascular injury><circulatory system><cognitive dysfunction><cognitive loss><cohort><conference><convention><critical period><dementia risk><diabetes><disease burden><disease phenotype><disparity in health><diverse populations><epigenetic aging><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic regulation of aging><epigenetically><ethnic difference><ethnicity difference><experience><faces><facial><health disparity><heterogeneous population><improved><intervention for prevention><intervention therapy><mid life><mid-life><middle age><middle aged><midlife><neural degeneration><neurodegeneration><neurodegenerative><neuroimaging biomarker><neuroimaging marker><neurological degeneration><neuronal degeneration><older adult><older adulthood><p-tau><p-τ><phospho-tau><phospho-τ><phosphorylated tau><polygenetic risk scores><polygenic risk score><population diversity><post-translational modification of tau><posttranslational modification of tau><prevent><preventing><prevention intervention><preventional intervention strategy><preventive intervention><primary degenerative dementia><racial population><racial subgroup><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social cultural factor><social culture><social culture determinant><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><summit><symposia><symposium><tau phosphorylation><tau posttranslational modification><tau-1><vascular><vascular contributions><vascular dysfunction><vasculopathy><τ phosphorylation>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

ELIZABETH MORMINO

STANFORD UNIVERSITY, STANFORD, CA

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,207,503

FY 2026

Project Title

Hippocampal-dependent memory decline in aging and early Alzheimer's disease

Grant Number:

5R01AG074339-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

The pathophysiological processes of Alzheimer’s disease (AD) –– betaamyloid plaques and neurofibrillary tangles –– begin decades before objective cognitive impairment and symptoms of clinical dementia are present. This “preclinical” disease stage offers a window to understand early disease mechanism...

Research Terms

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Nina Vanessa Kraguljac

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,110,398

FY 2026

Project Title

Multidimensional aging trajectories in mid to late-life psychosis (MAP)

Grant Number:

5R01MH135451-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Even though schizophrenia spectrum disorders (SSD) are generally considered to be neurodevelopmental in origin, emerging evidence supports the idea that aberrant brain aging may also occur. Because this concept has only recently reemerged, data on characteristic phenotypical and brain age-related tr...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Age><Aging><Anterior><Behavioral><Bioenergetics><Brain><Brain Nervous System><Brain region><Characteristics><Cognition><Cognitive aging><Data><Deterioration><Dimensions><Disease><Disorder><Dorsal><Dysfunction><Encephalon><Energy Expenditure><Energy Metabolism><Enrollment><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Funding Opportunities><General Population><General Public><Generalized Growth><Geroscience><Goals><Growth><Individual><Intermediary Metabolism><Knowledge><Literature><MR Spectroscopy><Magnetic Resonance Spectroscopy><Measures><Metabolic Processes><Metabolism><Modeling><Patients><Pattern><Performance><Physiopathology><Play><Psychoses><Psychotic Disorders><Role><Structure><Techniques><Thick><Thickness><Tissue Growth><Work><aberrant aging><abnormal aging><adulthood><age associated><age associated alterations><age associated changes><age associated decline><age associated effects><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent decline><age effect><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related decline><age related effects><age specific><age specific alterations><age specific changes><aged brain><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging process><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><changes with age><cingulate cortex><cognitive function><cognitive performance><cognitive task><compare to control><comparison control><decline with age><driving force><dysfunctional age related change><dysfunctional aging><enroll><fMRI><geroscientific><healthy volunteer><impact of age><impaired aging><in vivo><indexing><influence of age><insight><intervention design><late in life><late life><maladaptive aging><multi-modal neuro-imaging><multimodal neuroimaging><natural aging><normal aging><normative aging><novel><ontogeny><pathological age related changes><pathological aging><pathophysiology><prevent><preventing><psychotic illness><schizophrenia spectrum><schizophrenia spectrum disorder><social><social cognition><social role><therapy design><treatment design>

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ADRIENNE C LAHTI

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,110,398

FY 2026

Project Title

Multidimensional aging trajectories in mid to late-life psychosis (MAP)

Grant Number:

5R01MH135451-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Even though schizophrenia spectrum disorders (SSD) are generally considered to be neurodevelopmental in origin, emerging evidence supports the idea that aberrant brain aging may also occur. Because this concept has only recently reemerged, data on characteristic phenotypical and brain age-related tr...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Age><Aging><Anterior><Behavioral><Bioenergetics><Brain><Brain Nervous System><Brain region><Characteristics><Cognition><Cognitive aging><Data><Deterioration><Dimensions><Disease><Disorder><Dorsal><Dysfunction><Encephalon><Energy Expenditure><Energy Metabolism><Enrollment><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Funding Opportunities><General Population><General Public><Generalized Growth><Geroscience><Goals><Growth><Individual><Intermediary Metabolism><Knowledge><Literature><MR Spectroscopy><Magnetic Resonance Spectroscopy><Measures><Metabolic Processes><Metabolism><Modeling><Patients><Pattern><Performance><Physiopathology><Play><Psychoses><Psychotic Disorders><Role><Structure><Techniques><Thick><Thickness><Tissue Growth><Work><aberrant aging><abnormal aging><adulthood><age associated><age associated alterations><age associated changes><age associated decline><age associated effects><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent decline><age effect><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related decline><age related effects><age specific><age specific alterations><age specific changes><aged brain><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging process><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><changes with age><cingulate cortex><cognitive function><cognitive performance><cognitive task><compare to control><comparison control><decline with age><driving force><dysfunctional age related change><dysfunctional aging><enroll><fMRI><geroscientific><healthy volunteer><impact of age><impaired aging><in vivo><indexing><influence of age><insight><intervention design><late in life><late life><maladaptive aging><multi-modal neuro-imaging><multimodal neuroimaging><natural aging><normal aging><normative aging><novel><ontogeny><pathological age related changes><pathological aging><pathophysiology><prevent><preventing><psychotic illness><schizophrenia spectrum><schizophrenia spectrum disorder><social><social cognition><social role><therapy design><treatment design>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Junghee Lee

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,110,398

FY 2026

Project Title

Multidimensional aging trajectories in mid to late-life psychosis (MAP)

Grant Number:

5R01MH135451-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

Even though schizophrenia spectrum disorders (SSD) are generally considered to be neurodevelopmental in origin, emerging evidence supports the idea that aberrant brain aging may also occur. Because this concept has only recently reemerged, data on characteristic phenotypical and brain age-related tr...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Age><Aging><Anterior><Behavioral><Bioenergetics><Brain><Brain Nervous System><Brain region><Characteristics><Cognition><Cognitive aging><Data><Deterioration><Dimensions><Disease><Disorder><Dorsal><Dysfunction><Encephalon><Energy Expenditure><Energy Metabolism><Enrollment><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Funding Opportunities><General Population><General Public><Generalized Growth><Geroscience><Goals><Growth><Individual><Intermediary Metabolism><Knowledge><Literature><MR Spectroscopy><Magnetic Resonance Spectroscopy><Measures><Metabolic Processes><Metabolism><Modeling><Patients><Pattern><Performance><Physiopathology><Play><Psychoses><Psychotic Disorders><Role><Structure><Techniques><Thick><Thickness><Tissue Growth><Work><aberrant aging><abnormal aging><adulthood><age associated><age associated alterations><age associated changes><age associated decline><age associated effects><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent decline><age effect><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related decline><age related effects><age specific><age specific alterations><age specific changes><aged brain><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging process><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><changes with age><cingulate cortex><cognitive function><cognitive performance><cognitive task><compare to control><comparison control><decline with age><driving force><dysfunctional age related change><dysfunctional aging><enroll><fMRI><geroscientific><healthy volunteer><impact of age><impaired aging><in vivo><indexing><influence of age><insight><intervention design><late in life><late life><maladaptive aging><multi-modal neuro-imaging><multimodal neuroimaging><natural aging><normal aging><normative aging><novel><ontogeny><pathological age related changes><pathological aging><pathophysiology><prevent><preventing><psychotic illness><schizophrenia spectrum><schizophrenia spectrum disorder><social><social cognition><social role><therapy design><treatment design>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sai Krupa Das

TUFTS UNIVERSITY BOSTON, BOSTON, MA

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,005,155

FY 2026

Project Title

Legacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and Aging

Grant Number:

5R01AG071717-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2021

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY Calorie restriction (CR) is a promising nutritional strategy with the potential to slow the aging process. The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, funded by the National Institute on Aging, was the first clinical trial to demons...

Research Terms

<21+ years old><Active Follow-up><Address><Adult><Adult Human><Aerobic><Age><Aging><Algorithms><Amino-terminal pro-brain natriuretic peptide><Attenuated><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BNP Gene Product><BNP-32><BSF-2><BSF2><Baltimore><Basal Metabolism><Basal metabolic rate><Biological><Biological Aging><Biological Markers><Biological Specimen Banks><Biological Substance Banks><Blood><Blood Reticuloendothelial System><Body Composition><Body Measures><Body measure procedure><Brain Natriuretic Peptide-32><Brain natriuretic peptide><C-reactive protein><CD 120a Antigen><CD120a Antigens><Caloric Intake><Caloric Restriction><Cardiometabolic Disease><Cardiometabolic Disorder><Cell Aging><Cell Senescence><Cellular Aging><Cellular Senescence><Clinical Trials><Cognition><Communities><Control Groups><Data Banks><Databanks><Development><Dimethylbiguanidine><Dimethylguanylguanidine><Energy Intake><Exposure to><Fatigue><Follow-Up Studies><Funding><GDF15><GDF15 gene><Gait speed><General Population><General Public><Glycohemoglobin A><Glycosylated hemoglobin A><Goals><Grip strength><HPGF><Hand Strength><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Hemoglobin A(1)><Hepatocyte-Stimulating Factor><Human><Humulin R><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IGF-1><IGF-I><IGF-I-SmC><IL-6><IL6 Protein><Insulin><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Intake><Interleukin-6><Intervention><Isoprostanes><Lack of Energy><Long-Term Effects><MGI-2><MIC-1 gene product><MIC1><Macrophage Inhibitory Cytokine-1><Measurement><Measures><Metabolic syndrome><Metformin><Methods><Modern Man><Myeloid Differentiation-Inducing Protein><N,N-dimethyl-imidodicarbonimidic diamide><N-BNP peptide><N-terminal><N-terminal pro-BNP><NAG-1 protein><NAG1><NH2-terminal><NSAID activated gene-1 product><NSAID-Activated Protein 1><NSAID-Regulated Protein 1><NT-BNP><NT-proBNP><National Institute of Aging><National Institute on Aging><Natriuretic Factor-32><Nesiritide><Nonsteroidal Anti-Inflammatory Drug-Activated Protein 1><Novolin R><Nutritional><Obesity><Observational Study><Outcome><Oxidative Stress><PLAB><PLAB Protein><PTGF-Beta><Participant><Pattern><Phenotype><Placental Bone Morphogenic Protein><Placental TGF-Beta><Plasmacytoma Growth Factor><Prostate Differentiation Factor><Proteins><Proteins, specific or class, C-reactive><Public Health><QOL><Quality Control><Quality of life><Randomized, Controlled Trials><Regular Insulin><Replicative Senescence><Risk><Sampling><Sleep><Somatomedin C><TNF Receptor p55><TNF-sR55><TNF-α receptor><TNFAR><TNFR p60><TNFR, 55-kD><TNFR, 60-kD><TNFR-I><TNFR1><TNFR55><TNFR60><TNFRSF1A><TNFRSF1A Receptor><TNFRSF1A gene><TNFalpha receptor><TNFα receptor><Testing><Tumor Necrosis Factor Receptor 1><Tumor Necrosis Factor Receptor 55><Type-B Natriuretic Peptide><Urine><VO2 max><VO2max><active followup><adiposity><adulthood><age associated chronic condition><age associated chronic disease><age associated chronic disorder><age associated chronic health condition><age associated chronic illness><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related chronic condition><age related chronic disease><age related chronic disorder><age related chronic health condition><age related chronic illness><age related human disease><age-related disease><age-related disorder><age-related impairment><ages><aging biological marker><aging biomarker><aging delay><aging marker><aging process><assess effectiveness><attenuate><attenuate aging><attenuates><behavior change><bio-markers><biobehavior><biobehavioral><biologic><biologic marker><biological age><biological process of age><biological specimen repository><biomarker><biosample repository><biospecimen bank><biospecimen repository><blood-based biomarker><blood-based marker><brain Natriuretic factor><caloric dietary content><calorie restriction><cardiorespiratory fitness><cardiorespiratory health><cognitive function><cohort><comparator group><comparison group><corpulence><cystatin C><data depository><data repository><data set repository><dataset repository><decelerate aging><delay age related><design><designing><determine effectiveness><developmental><diet and exercise><disease risk><disorder risk><effectiveness assessment><effectiveness evaluation><energy efficiency><evaluate effectiveness><examine effectiveness><experience><follow up><follow-up><follow-up research study><follow-up survey><followed up><followup><geroprotectant><geroprotective><geroprotector><growth differentiation factor 15><healthspan><healthy aging><healthy human aging><healthy life span><hemoglobin A1c><improved><indexing><interferon beta 2><life style intervention><lifestyle intervention><longitudinal aging study><longitudinal aging survey><longitudinal study in aging><longitudinal study on aging><maximal oxygen uptake><mid life><mid-life><middle age><middle aged><midlife><model organism><motivated behavior><novel><nutritious><observational research study><observational survey><pace of aging><pace of biological aging><pause aging><post gamma-globulins><post-gamma-protein><postpone age related><prevent><preventing><primary outcome><pro-brain natriuretic peptide (1-76)><proBNP(1-76)><psychologic><psychological><randomized control trial><rate of aging><rate of biological aging><replicative aging><resting metabolic rate><retards aging><senescence and its associated secretory phenotype><senescence associated secretome><senescence associated secretory factors><senescence associated secretory pathway><senescence associated secretory phenotype><senescence associated secretory program><senescence associated secretory proteins><senescent associated secretome><senescent associated secretory phenotype><slow aging><slow down aging><slow the rate of aging><specimen bank><specimen repository><speed of aging><speed of the aging><study with follow-up><tumor necrosis factor alpha receptor><tumor necrosis factor receptor 1A><tumor necrosis factor α receptor><urinary><younger age>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Susan Beth Racette

TUFTS UNIVERSITY BOSTON, BOSTON, MA

High-opportunity lead · 72/100

Likely hiring

Large award

Recent

Active award

$1,005,155

FY 2026

Project Title

Legacy Effects of CALERIE, a 2-year Calorie Restriction Intervention, on Hallmarks of Healthspan and Aging

Grant Number:

5R01AG071717-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2021

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY Calorie restriction (CR) is a promising nutritional strategy with the potential to slow the aging process. The Comprehensive Assessment of Long-term Effects of Reducing Intake of Energy (CALERIE) trial, funded by the National Institute on Aging, was the first clinical trial to demons...

Research Terms

<21+ years old><Active Follow-up><Address><Adult><Adult Human><Aerobic><Age><Aging><Algorithms><Amino-terminal pro-brain natriuretic peptide><Attenuated><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BNP Gene Product><BNP-32><BSF-2><BSF2><Baltimore><Basal Metabolism><Basal metabolic rate><Biological><Biological Aging><Biological Markers><Biological Specimen Banks><Biological Substance Banks><Blood><Blood Reticuloendothelial System><Body Composition><Body Measures><Body measure procedure><Brain Natriuretic Peptide-32><Brain natriuretic peptide><C-reactive protein><CD 120a Antigen><CD120a Antigens><Caloric Intake><Caloric Restriction><Cardiometabolic Disease><Cardiometabolic Disorder><Cell Aging><Cell Senescence><Cellular Aging><Cellular Senescence><Clinical Trials><Cognition><Communities><Control Groups><Data Banks><Databanks><Development><Dimethylbiguanidine><Dimethylguanylguanidine><Energy Intake><Exposure to><Fatigue><Follow-Up Studies><Funding><GDF15><GDF15 gene><Gait speed><General Population><General Public><Glycohemoglobin A><Glycosylated hemoglobin A><Goals><Grip strength><HPGF><Hand Strength><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Hemoglobin A(1)><Hepatocyte-Stimulating Factor><Human><Humulin R><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IGF-1><IGF-I><IGF-I-SmC><IL-6><IL6 Protein><Insulin><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Intake><Interleukin-6><Intervention><Isoprostanes><Lack of Energy><Long-Term Effects><MGI-2><MIC-1 gene product><MIC1><Macrophage Inhibitory Cytokine-1><Measurement><Measures><Metabolic syndrome><Metformin><Methods><Modern Man><Myeloid Differentiation-Inducing Protein><N,N-dimethyl-imidodicarbonimidic diamide><N-BNP peptide><N-terminal><N-terminal pro-BNP><NAG-1 protein><NAG1><NH2-terminal><NSAID activated gene-1 product><NSAID-Activated Protein 1><NSAID-Regulated Protein 1><NT-BNP><NT-proBNP><National Institute of Aging><National Institute on Aging><Natriuretic Factor-32><Nesiritide><Nonsteroidal Anti-Inflammatory Drug-Activated Protein 1><Novolin R><Nutritional><Obesity><Observational Study><Outcome><Oxidative Stress><PLAB><PLAB Protein><PTGF-Beta><Participant><Pattern><Phenotype><Placental Bone Morphogenic Protein><Placental TGF-Beta><Plasmacytoma Growth Factor><Prostate Differentiation Factor><Proteins><Proteins, specific or class, C-reactive><Public Health><QOL><Quality Control><Quality of life><Randomized, Controlled Trials><Regular Insulin><Replicative Senescence><Risk><Sampling><Sleep><Somatomedin C><TNF Receptor p55><TNF-sR55><TNF-α receptor><TNFAR><TNFR p60><TNFR, 55-kD><TNFR, 60-kD><TNFR-I><TNFR1><TNFR55><TNFR60><TNFRSF1A><TNFRSF1A Receptor><TNFRSF1A gene><TNFalpha receptor><TNFα receptor><Testing><Tumor Necrosis Factor Receptor 1><Tumor Necrosis Factor Receptor 55><Type-B Natriuretic Peptide><Urine><VO2 max><VO2max><active followup><adiposity><adulthood><age associated chronic condition><age associated chronic disease><age associated chronic disorder><age associated chronic health condition><age associated chronic illness><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related chronic condition><age related chronic disease><age related chronic disorder><age related chronic health condition><age related chronic illness><age related human disease><age-related disease><age-related disorder><age-related impairment><ages><aging biological marker><aging biomarker><aging delay><aging marker><aging process><assess effectiveness><attenuate><attenuate aging><attenuates><behavior change><bio-markers><biobehavior><biobehavioral><biologic><biologic marker><biological age><biological process of age><biological specimen repository><biomarker><biosample repository><biospecimen bank><biospecimen repository><blood-based biomarker><blood-based marker><brain Natriuretic factor><caloric dietary content><calorie restriction><cardiorespiratory fitness><cardiorespiratory health><cognitive function><cohort><comparator group><comparison group><corpulence><cystatin C><data depository><data repository><data set repository><dataset repository><decelerate aging><delay age related><design><designing><determine effectiveness><developmental><diet and exercise><disease risk><disorder risk><effectiveness assessment><effectiveness evaluation><energy efficiency><evaluate effectiveness><examine effectiveness><experience><follow up><follow-up><follow-up research study><follow-up survey><followed up><followup><geroprotectant><geroprotective><geroprotector><growth differentiation factor 15><healthspan><healthy aging><healthy human aging><healthy life span><hemoglobin A1c><improved><indexing><interferon beta 2><life style intervention><lifestyle intervention><longitudinal aging study><longitudinal aging survey><longitudinal study in aging><longitudinal study on aging><maximal oxygen uptake><mid life><mid-life><middle age><middle aged><midlife><model organism><motivated behavior><novel><nutritious><observational research study><observational survey><pace of aging><pace of biological aging><pause aging><post gamma-globulins><post-gamma-protein><postpone age related><prevent><preventing><primary outcome><pro-brain natriuretic peptide (1-76)><proBNP(1-76)><psychologic><psychological><randomized control trial><rate of aging><rate of biological aging><replicative aging><resting metabolic rate><retards aging><senescence and its associated secretory phenotype><senescence associated secretome><senescence associated secretory factors><senescence associated secretory pathway><senescence associated secretory phenotype><senescence associated secretory program><senescence associated secretory proteins><senescent associated secretome><senescent associated secretory phenotype><slow aging><slow down aging><slow the rate of aging><specimen bank><specimen repository><speed of aging><speed of the aging><study with follow-up><tumor necrosis factor alpha receptor><tumor necrosis factor receptor 1A><tumor necrosis factor α receptor><urinary><younger age>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Hongjie Li

HARVARD MEDICAL SCHOOL, BOSTON, MA

Good lead · 68/100

Likely hiring

Above-average budget

Active award

Team-scale grant

$642,249

FY 2026

Project Title

Interorgan communication in aging in Drosophila

Grant Number:

5U01AG086143-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Aging is a complex condition with diverse physiological effects ranging from the cellular to organismal levels, such as the dysregulation of metabolism. While many distinct aspects of aging have been characterized, a wholistic understanding of how these aspects function toge...

Research Terms

<21+ years old><Acceleration><Address><Adipose tissue><Adult><Adult Human><Affect><Age><Aging><Animals><Atlases><Basal Transcription Factor><Basal transcription factor genes><Biochemical Pathway><Bioinformatics><Biologic Models><Biological Models><Biology of Aging><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cells><Cellular Stress><Cellular Stress Response><Cessation of life><Chronic><Communication><Complex><Data><Data Set><Death><Degenerative Neurologic Disorders><Differences between sexes><Differs between sexes><Disease><Disorder><Distant><Drosophila><Drosophila genus><Drosophila melanogaster><Enzyme Gene><Enzymes><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Fat Body><Fats><Fatty Tissue><Fatty acid glycerol esters><Flies><Funding Opportunities><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Transcription><Health><Health Promotion><Human><Increase lifespan><Individual><Intermediary Metabolism><Intracellular Communication and Signaling><Label><Length of Life><Ligands><Link><Longevity><MT-bound tau><Measures><Mechanistic Target of Rapamycin><Mediating><Metabolic><Metabolic Networks><Metabolic Pathway><Metabolic Processes><Metabolism><Model System><Modeling><Modern Man><Molecular><Muscle><Muscle Tissue><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Nucleus><Organ><Organism><Pathway interactions><Peripheral><Physiologic><Physiological><Process><Protein Secretion><Proteins><Proteomics><RAFT1><RNA Expression><Rapamune><Rapamycin><Receptor Protein><Reporting><Research><Role><Salutogenesis><Science><Severities><Sex Differences><Sexual differences><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Sirolimus><Stress><System><Systems Biology><Tauopathies><Time><Tissue Model><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Whole Organism><Work><XBP1><XBP1 gene><adipose><adulthood><age associated><age associated effects><age correlated><age dependent><age effect><age linked><age related><age related effects><age related pathways><age specific><aged><ages><aging associated mechanism><aging effect><aging mechanism><aging pathway><aging prevention><aging related mechanism><aging related pathways><anti aging><anti geronic><antiaging><biological age><biological mechanism of age><biological pathways of age><biological signal transduction><boost longevity><cell stress><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><feeding><fly><foster longevity><fruit fly><healthspan><healthy life span><impact of age><improve lifespan><improve longevity><influence of age><insight><life span><lifespan><lifespan extension><living system><mTOR><mTOR inhibition><mammalian target of rapamycin><mechanism regulating aging><mechanisms involved in aging><metabolism measurement><metabolomics><metabonomics><microtubule bound tau><microtubule-bound tau><multiomics><multiple omics><muscle degeneration><muscle stress><muscular><natural aging><neural><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><neuropathologic tau><neuropathological tau><normal aging><normative aging><novel><overexpress><overexpression><panomics><pathway><pathway involved in aging><premature><prematurity><prevent age related><prevent aging><pro-aging><progeronic><programs><prolong lifespan><prolong longevity><promote aging><promote lifespan><promote longevity><promoting health><receptor><response><sNuc-Seq><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><support longevity><suppress aging><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><transcription factor><transcriptomics><white adipose tissue><yellow adipose tissue><τ Proteins>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

NORBERT PERRIMON

HARVARD MEDICAL SCHOOL, BOSTON, MA

Good lead · 68/100

Likely hiring

Above-average budget

Active award

Team-scale grant

$642,249

FY 2026

Project Title

Interorgan communication in aging in Drosophila

Grant Number:

5U01AG086143-03

Activity Code:

U01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Aging is a complex condition with diverse physiological effects ranging from the cellular to organismal levels, such as the dysregulation of metabolism. While many distinct aspects of aging have been characterized, a wholistic understanding of how these aspects function toge...

Research Terms

<21+ years old><Acceleration><Address><Adipose tissue><Adult><Adult Human><Affect><Age><Aging><Animals><Atlases><Basal Transcription Factor><Basal transcription factor genes><Biochemical Pathway><Bioinformatics><Biologic Models><Biological Models><Biology of Aging><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cells><Cellular Stress><Cellular Stress Response><Cessation of life><Chronic><Communication><Complex><Data><Data Set><Death><Degenerative Neurologic Disorders><Differences between sexes><Differs between sexes><Disease><Disorder><Distant><Drosophila><Drosophila genus><Drosophila melanogaster><Enzyme Gene><Enzymes><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Fat Body><Fats><Fatty Tissue><Fatty acid glycerol esters><Flies><Funding Opportunities><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Transcription><Health><Health Promotion><Human><Increase lifespan><Individual><Intermediary Metabolism><Intracellular Communication and Signaling><Label><Length of Life><Ligands><Link><Longevity><MT-bound tau><Measures><Mechanistic Target of Rapamycin><Mediating><Metabolic><Metabolic Networks><Metabolic Pathway><Metabolic Processes><Metabolism><Model System><Modeling><Modern Man><Molecular><Muscle><Muscle Tissue><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Nucleus><Organ><Organism><Pathway interactions><Peripheral><Physiologic><Physiological><Process><Protein Secretion><Proteins><Proteomics><RAFT1><RNA Expression><Rapamune><Rapamycin><Receptor Protein><Reporting><Research><Role><Salutogenesis><Science><Severities><Sex Differences><Sexual differences><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Sirolimus><Stress><System><Systems Biology><Tauopathies><Time><Tissue Model><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Whole Organism><Work><XBP1><XBP1 gene><adipose><adulthood><age associated><age associated effects><age correlated><age dependent><age effect><age linked><age related><age related effects><age related pathways><age specific><aged><ages><aging associated mechanism><aging effect><aging mechanism><aging pathway><aging prevention><aging related mechanism><aging related pathways><anti aging><anti geronic><antiaging><biological age><biological mechanism of age><biological pathways of age><biological signal transduction><boost longevity><cell stress><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><feeding><fly><foster longevity><fruit fly><healthspan><healthy life span><impact of age><improve lifespan><improve longevity><influence of age><insight><life span><lifespan><lifespan extension><living system><mTOR><mTOR inhibition><mammalian target of rapamycin><mechanism regulating aging><mechanisms involved in aging><metabolism measurement><metabolomics><metabonomics><microtubule bound tau><microtubule-bound tau><multiomics><multiple omics><muscle degeneration><muscle stress><muscular><natural aging><neural><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><neuropathologic tau><neuropathological tau><normal aging><normative aging><novel><overexpress><overexpression><panomics><pathway><pathway involved in aging><premature><prematurity><prevent age related><prevent aging><pro-aging><progeronic><programs><prolong lifespan><prolong longevity><promote aging><promote lifespan><promote longevity><promoting health><receptor><response><sNuc-Seq><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><support longevity><suppress aging><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><transcription factor><transcriptomics><white adipose tissue><yellow adipose tissue><τ Proteins>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Rozalyn M. Anderson

TEXAS A&M AGRILIFE RESEARCH, College Station, TX

Good lead · 66/100

Likely hiring

Large award

Active award

$2,636,580

FY 2026

Project Title

Test of Rapamycin in Aging Dogs (TRIAD)

Grant Number:

5R01AG090843-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

SUMMARY Rapamycin is one of the most promising geroprotective agents identified to date, with proven ability to enhance longevity and improve health in laboratory animals and promising outcomes from more limited human studies. Originally embedded within the Dog Aging Project (DAP), the Test of Rapam...

Research Terms

<7 year old><7 years of age><AD dementia><AD like pathology><Active Follow-up><Address><Adherence><Adverse Experience><Adverse event><Age><Aging><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer like pathology><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease like pathology><Alzheimers Dementia><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Arteries><Autopsy><Aβ><Blood><Blood Plasma><Blood Pressure><Blood Reticuloendothelial System><Board Certification><Body Weight decreased><Brain><Brain Nervous System><Cancers><Canine Species><Canis familiaris><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cellular Immune Function><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinic><Clinical><Clinical Evaluation><Clinical Testing><Clinical Trials><Clinical Trials Design><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communicable Diseases><Data><Data Analyses><Data Analysis><Disease><Disorder><Disturbance in cognition><Dogs><Dogs Mammals><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><ECG><EKG><Echocardiogram><Echocardiography><Electrocardiogram><Electrocardiography><Eligibility><Eligibility Determination><Encephalon><Enrollment><Exclusion><Experimental Organism><Formulation><Foundations><Funding><Future><Gait speed><Geroscience><Health><Health Status><Heart Vascular><Home><Human><Impaired cognition><Incidence><Increase lifespan><Infectious Diseases><Infectious Disorder><Infrastructure><Joint Diseases><Joints><Laboratories><Laboratory Animals><Laboratory Organism><Laboratory Study><Length of Life><Level of Health><Logistics><Longevity><Malignant Neoplasms><Malignant Tumor><Measures><Modern Man><Monitor><Motor><Nervous System Physiology><Neurologic><Neurologic function><Neurological><Neurological function><Neurologist><Onset of illness><Outcome><Outcome Measure><Physical Function><Pilot Projects><Placebo Control><Plasma><Plasma Serum><Primary Senile Degenerative Dementia><Privatization><Protocol><Protocol Screening><Protocols documentation><Randomized><Rapamune><Rapamycin><Records><Reporting><Reticuloendothelial System, Serum, Plasma><Rodent Model><Sampling><Schedule><Sensory><Sirolimus><Site><Specialty><Speed><Survey Instrument><Surveys><Survival Analyses><Survival Analysis><Testing><Thigh><Thigh structure><Time><Transthoracic Echocardiography><Treatment Period><Weight Loss><Weight Reduction><a beta peptide><abeta><access to health care><accessibility of health care><accessibility to health care><active followup><age 7><age 7 years><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><ages><aging prevention><amyloid beta><amyloid-b protein><anti aging><anti aging based therapeutic><anti aging therapeutic><anti geronic><anti-aging property therapeutic><antiaging><arthropathic><arthropathies><arthropathy><beta amyloid fibril><body weight loss><boost longevity><canine><cardiac function><chronic kidney disease><circulatory system><clinical research site><clinical site><clinical test><cognitive assessment><cognitive dysfunction><cognitive loss><cognitive testing><companion dog><data acquisition><data acquisitions><data interpretation><data pipeline><design><designing><disease onset><disorder onset><domestic dog><efficacy study><elongating the lifespan><enhance healthspan><enhance longevity><enroll><extend healthspan><extend life span><extend lifespan><extend longevity><extending healthy lifespan><follow up><follow-up><followed up><followup><foster longevity><frailty><function of the heart><geroprotectant><geroprotective><geroprotector><geroscience therapeutic><geroscientific><gerotherapeutic><health care access><health care availability><health care service access><health care service availability><health level><healthspan><healthspan extension><healthy aging><healthy human aging><healthy life span><heart function><heart sonography><homes><immune function><immune health><immune system health><improve healthspan><improve lifespan><improve longevity><improved><increase healthspan><joint disorder><life span><lifespan><lifespan extension><malignancy><measurable outcome><medical specialties><mid life><mid-life><middle age><middle aged><midlife><mortality><natural aging><necropsy><neoplasm/cancer><nervous system function><normal aging><normative aging><older adult><older adulthood><outcome measurement><p-tau><p-τ><phospho-tau><phospho-τ><phosphorylated tau><pilot study><placebo controlled><placebo group><post-translational modification of tau><postmortem><posttranslational modification of tau><prevent age related><prevent aging><primary degenerative dementia><prolong healthspan><prolong lifespan><prolong longevity><promote healthspan><promote lifespan><promote longevity><randomisation><randomization><randomly assigned><rapid detection><recruit><research clinical testing><senile dementia of the Alzheimer type><seven year old><seven years of age><sham group><side effect><simulation><soluble amyloid precursor protein><support longevity><suppress aging><tau phosphorylation><tau posttranslational modification><tau-1><therapeutic against aging><therapeutic interventions against aging><therapeutic strategies for aging><therapeutic strategies targeting aging><therapeutic target for anti-aging><therapeutic targeting aging><therapeutic targets to reverse aging><therapeutic to prevent aging><therapeutics impacts on aging><therapeutics that slow aging><treatment days><treatment duration><treatment group><wt-loss><τ phosphorylation>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kate Elizabeth Creevy

TEXAS A&M AGRILIFE RESEARCH, College Station, TX

Good lead · 66/100

Likely hiring

Large award

Active award

$2,636,580

FY 2026

Project Title

Test of Rapamycin in Aging Dogs (TRIAD)

Grant Number:

5R01AG090843-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

SUMMARY Rapamycin is one of the most promising geroprotective agents identified to date, with proven ability to enhance longevity and improve health in laboratory animals and promising outcomes from more limited human studies. Originally embedded within the Dog Aging Project (DAP), the Test of Rapam...

Research Terms

<7 year old><7 years of age><AD dementia><AD like pathology><Active Follow-up><Address><Adherence><Adverse Experience><Adverse event><Age><Aging><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer like pathology><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease like pathology><Alzheimers Dementia><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Arteries><Autopsy><Aβ><Blood><Blood Plasma><Blood Pressure><Blood Reticuloendothelial System><Board Certification><Body Weight decreased><Brain><Brain Nervous System><Cancers><Canine Species><Canis familiaris><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cellular Immune Function><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinic><Clinical><Clinical Evaluation><Clinical Testing><Clinical Trials><Clinical Trials Design><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communicable Diseases><Data><Data Analyses><Data Analysis><Disease><Disorder><Disturbance in cognition><Dogs><Dogs Mammals><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><ECG><EKG><Echocardiogram><Echocardiography><Electrocardiogram><Electrocardiography><Eligibility><Eligibility Determination><Encephalon><Enrollment><Exclusion><Experimental Organism><Formulation><Foundations><Funding><Future><Gait speed><Geroscience><Health><Health Status><Heart Vascular><Home><Human><Impaired cognition><Incidence><Increase lifespan><Infectious Diseases><Infectious Disorder><Infrastructure><Joint Diseases><Joints><Laboratories><Laboratory Animals><Laboratory Organism><Laboratory Study><Length of Life><Level of Health><Logistics><Longevity><Malignant Neoplasms><Malignant Tumor><Measures><Modern Man><Monitor><Motor><Nervous System Physiology><Neurologic><Neurologic function><Neurological><Neurological function><Neurologist><Onset of illness><Outcome><Outcome Measure><Physical Function><Pilot Projects><Placebo Control><Plasma><Plasma Serum><Primary Senile Degenerative Dementia><Privatization><Protocol><Protocol Screening><Protocols documentation><Randomized><Rapamune><Rapamycin><Records><Reporting><Reticuloendothelial System, Serum, Plasma><Rodent Model><Sampling><Schedule><Sensory><Sirolimus><Site><Specialty><Speed><Survey Instrument><Surveys><Survival Analyses><Survival Analysis><Testing><Thigh><Thigh structure><Time><Transthoracic Echocardiography><Treatment Period><Weight Loss><Weight Reduction><a beta peptide><abeta><access to health care><accessibility of health care><accessibility to health care><active followup><age 7><age 7 years><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><ages><aging prevention><amyloid beta><amyloid-b protein><anti aging><anti aging based therapeutic><anti aging therapeutic><anti geronic><anti-aging property therapeutic><antiaging><arthropathic><arthropathies><arthropathy><beta amyloid fibril><body weight loss><boost longevity><canine><cardiac function><chronic kidney disease><circulatory system><clinical research site><clinical site><clinical test><cognitive assessment><cognitive dysfunction><cognitive loss><cognitive testing><companion dog><data acquisition><data acquisitions><data interpretation><data pipeline><design><designing><disease onset><disorder onset><domestic dog><efficacy study><elongating the lifespan><enhance healthspan><enhance longevity><enroll><extend healthspan><extend life span><extend lifespan><extend longevity><extending healthy lifespan><follow up><follow-up><followed up><followup><foster longevity><frailty><function of the heart><geroprotectant><geroprotective><geroprotector><geroscience therapeutic><geroscientific><gerotherapeutic><health care access><health care availability><health care service access><health care service availability><health level><healthspan><healthspan extension><healthy aging><healthy human aging><healthy life span><heart function><heart sonography><homes><immune function><immune health><immune system health><improve healthspan><improve lifespan><improve longevity><improved><increase healthspan><joint disorder><life span><lifespan><lifespan extension><malignancy><measurable outcome><medical specialties><mid life><mid-life><middle age><middle aged><midlife><mortality><natural aging><necropsy><neoplasm/cancer><nervous system function><normal aging><normative aging><older adult><older adulthood><outcome measurement><p-tau><p-τ><phospho-tau><phospho-τ><phosphorylated tau><pilot study><placebo controlled><placebo group><post-translational modification of tau><postmortem><posttranslational modification of tau><prevent age related><prevent aging><primary degenerative dementia><prolong healthspan><prolong lifespan><prolong longevity><promote healthspan><promote lifespan><promote longevity><randomisation><randomization><randomly assigned><rapid detection><recruit><research clinical testing><senile dementia of the Alzheimer type><seven year old><seven years of age><sham group><side effect><simulation><soluble amyloid precursor protein><support longevity><suppress aging><tau phosphorylation><tau posttranslational modification><tau-1><therapeutic against aging><therapeutic interventions against aging><therapeutic strategies for aging><therapeutic strategies targeting aging><therapeutic target for anti-aging><therapeutic targeting aging><therapeutic targets to reverse aging><therapeutic to prevent aging><therapeutics impacts on aging><therapeutics that slow aging><treatment days><treatment duration><treatment group><wt-loss><τ phosphorylation>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

MAY J REED

TEXAS A&M AGRILIFE RESEARCH, College Station, TX

Good lead · 66/100

Likely hiring

Large award

Active award

$2,636,580

FY 2026

Project Title

Test of Rapamycin in Aging Dogs (TRIAD)

Grant Number:

5R01AG090843-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

SUMMARY Rapamycin is one of the most promising geroprotective agents identified to date, with proven ability to enhance longevity and improve health in laboratory animals and promising outcomes from more limited human studies. Originally embedded within the Dog Aging Project (DAP), the Test of Rapam...

Research Terms

<7 year old><7 years of age><AD dementia><AD like pathology><Active Follow-up><Address><Adherence><Adverse Experience><Adverse event><Age><Aging><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer like pathology><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease like pathology><Alzheimers Dementia><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Arteries><Autopsy><Aβ><Blood><Blood Plasma><Blood Pressure><Blood Reticuloendothelial System><Board Certification><Body Weight decreased><Brain><Brain Nervous System><Cancers><Canine Species><Canis familiaris><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cellular Immune Function><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinic><Clinical><Clinical Evaluation><Clinical Testing><Clinical Trials><Clinical Trials Design><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communicable Diseases><Data><Data Analyses><Data Analysis><Disease><Disorder><Disturbance in cognition><Dogs><Dogs Mammals><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><ECG><EKG><Echocardiogram><Echocardiography><Electrocardiogram><Electrocardiography><Eligibility><Eligibility Determination><Encephalon><Enrollment><Exclusion><Experimental Organism><Formulation><Foundations><Funding><Future><Gait speed><Geroscience><Health><Health Status><Heart Vascular><Home><Human><Impaired cognition><Incidence><Increase lifespan><Infectious Diseases><Infectious Disorder><Infrastructure><Joint Diseases><Joints><Laboratories><Laboratory Animals><Laboratory Organism><Laboratory Study><Length of Life><Level of Health><Logistics><Longevity><Malignant Neoplasms><Malignant Tumor><Measures><Modern Man><Monitor><Motor><Nervous System Physiology><Neurologic><Neurologic function><Neurological><Neurological function><Neurologist><Onset of illness><Outcome><Outcome Measure><Physical Function><Pilot Projects><Placebo Control><Plasma><Plasma Serum><Primary Senile Degenerative Dementia><Privatization><Protocol><Protocol Screening><Protocols documentation><Randomized><Rapamune><Rapamycin><Records><Reporting><Reticuloendothelial System, Serum, Plasma><Rodent Model><Sampling><Schedule><Sensory><Sirolimus><Site><Specialty><Speed><Survey Instrument><Surveys><Survival Analyses><Survival Analysis><Testing><Thigh><Thigh structure><Time><Transthoracic Echocardiography><Treatment Period><Weight Loss><Weight Reduction><a beta peptide><abeta><access to health care><accessibility of health care><accessibility to health care><active followup><age 7><age 7 years><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><ages><aging prevention><amyloid beta><amyloid-b protein><anti aging><anti aging based therapeutic><anti aging therapeutic><anti geronic><anti-aging property therapeutic><antiaging><arthropathic><arthropathies><arthropathy><beta amyloid fibril><body weight loss><boost longevity><canine><cardiac function><chronic kidney disease><circulatory system><clinical research site><clinical site><clinical test><cognitive assessment><cognitive dysfunction><cognitive loss><cognitive testing><companion dog><data acquisition><data acquisitions><data interpretation><data pipeline><design><designing><disease onset><disorder onset><domestic dog><efficacy study><elongating the lifespan><enhance healthspan><enhance longevity><enroll><extend healthspan><extend life span><extend lifespan><extend longevity><extending healthy lifespan><follow up><follow-up><followed up><followup><foster longevity><frailty><function of the heart><geroprotectant><geroprotective><geroprotector><geroscience therapeutic><geroscientific><gerotherapeutic><health care access><health care availability><health care service access><health care service availability><health level><healthspan><healthspan extension><healthy aging><healthy human aging><healthy life span><heart function><heart sonography><homes><immune function><immune health><immune system health><improve healthspan><improve lifespan><improve longevity><improved><increase healthspan><joint disorder><life span><lifespan><lifespan extension><malignancy><measurable outcome><medical specialties><mid life><mid-life><middle age><middle aged><midlife><mortality><natural aging><necropsy><neoplasm/cancer><nervous system function><normal aging><normative aging><older adult><older adulthood><outcome measurement><p-tau><p-τ><phospho-tau><phospho-τ><phosphorylated tau><pilot study><placebo controlled><placebo group><post-translational modification of tau><postmortem><posttranslational modification of tau><prevent age related><prevent aging><primary degenerative dementia><prolong healthspan><prolong lifespan><prolong longevity><promote healthspan><promote lifespan><promote longevity><randomisation><randomization><randomly assigned><rapid detection><recruit><research clinical testing><senile dementia of the Alzheimer type><seven year old><seven years of age><sham group><side effect><simulation><soluble amyloid precursor protein><support longevity><suppress aging><tau phosphorylation><tau posttranslational modification><tau-1><therapeutic against aging><therapeutic interventions against aging><therapeutic strategies for aging><therapeutic strategies targeting aging><therapeutic target for anti-aging><therapeutic targeting aging><therapeutic targets to reverse aging><therapeutic to prevent aging><therapeutics impacts on aging><therapeutics that slow aging><treatment days><treatment duration><treatment group><wt-loss><τ phosphorylation>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

ANNE BRUNET

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100

Likely hiring

Large award

Active award

$1,468,868

FY 2026

Project Title

The brain as a control center for other organs during aging

Grant Number:

1R01AG097491-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

SUMMARY The goal of this multi-investigator proposal is to determine how the brain can act as ‘neural pacemaker’ to regulate the tempo of aging of the whole organism. Aging is a multifaceted process that alters the function of every organ and is associated with devastating diseases. An inherent limi...

Research Terms

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Karl A. Deisseroth

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100

Likely hiring

Large award

Active award

$1,468,868

FY 2026

Project Title

The brain as a control center for other organs during aging

Grant Number:

1R01AG097491-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

SUMMARY The goal of this multi-investigator proposal is to determine how the brain can act as ‘neural pacemaker’ to regulate the tempo of aging of the whole organism. Aging is a multifaceted process that alters the function of every organ and is associated with devastating diseases. An inherent limi...

Research Terms

View Full Project Details on NIH Reporter

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Daniel Jarosz

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100

Likely hiring

Large award

Active award

$1,468,868

FY 2026

Project Title

The brain as a control center for other organs during aging

Grant Number:

1R01AG097491-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

SUMMARY The goal of this multi-investigator proposal is to determine how the brain can act as ‘neural pacemaker’ to regulate the tempo of aging of the whole organism. Aging is a multifaceted process that alters the function of every organ and is associated with devastating diseases. An inherent limi...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Scott Warren Linderman

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100

Likely hiring

Large award

Active award

$1,468,868

FY 2026

Project Title

The brain as a control center for other organs during aging

Grant Number:

1R01AG097491-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

SUMMARY The goal of this multi-investigator proposal is to determine how the brain can act as ‘neural pacemaker’ to regulate the tempo of aging of the whole organism. Aging is a multifaceted process that alters the function of every organ and is associated with devastating diseases. An inherent limi...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

TONY WYSS-CORAY

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 66/100

Likely hiring

Large award

Active award

$1,468,868

FY 2026

Project Title

The brain as a control center for other organs during aging

Grant Number:

1R01AG097491-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Large budget suggests more room for personnel or project growth.

Project Abstract

SUMMARY The goal of this multi-investigator proposal is to determine how the brain can act as ‘neural pacemaker’ to regulate the tempo of aging of the whole organism. Aging is a multifaceted process that alters the function of every organ and is associated with devastating diseases. An inherent limi...

Research Terms

View Full Project Details on NIH Reporter

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Rebeca Wong

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$988,101

FY 2026

Project Title

The Mexican Health Aging Study (MHAS)

Grant Number:

5R01AG018016-20

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/1999

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The Mexican Health and Aging Study (MHAS) is a longitudinal study using a national sample of community-dwelling adults aged 50 and older in urban and rural Mexico. Six waves of data collection over 20 years have been completed. Since its inception, the protocols and survey instruments are highly com...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD related dementia><ADRD><Active Follow-up><Address><Adult><Adult Human><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Ancillary Study><Blood><Blood Reticuloendothelial System><COVID-19><CV-19><Cognitive><Cognitive aging><Cohort Analyses><Cohort Analysis><Collaborations><Communities><Coronavirus Infectious Disease 2019><Country><DNA Methylation><Data><Data Bases><Data Collection><Databases><Developing Countries><Developing Nations><Dimensions><Documentation><Economic Income><Economical Income><Economics><Elderly><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Family><Fostering><Funding><Genetic><Geography><Geriatrics><Goals><Health><Health Care><Health Care Technology><Health Technology><Health and Retirement Study><Health behavior><Income><Individual><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Knowledge><Language><Latin America><Lead><Length><Less-Developed Countries><Less-Developed Nations><Life Cycle><Life Cycle Stages><Link><Longitudinal Studies><Longitudinal Surveys><Mental Health><Mental Hygiene><Mexican><Mexico><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><Participant><Patient Self-Report><Pb element><Peer Review><Physical Function><Population><Position><Positioning Attribute><Prejudice><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Psychological Health><Research><Research Personnel><Research Support><Researchers><Retirement><Running><Rural><Saliva><Sampling><Self-Report><Social Protection><Spanish/English><Structure><Survey Instrument><Surveys><Third-World Countries><Third-World Nations><Under-Developed Countries><Under-Developed Nations><United States><United States National Institutes of Health><Venous><Work><access to health care><accessibility of health care><accessibility to health care><active followup><adulthood><advanced age><aged><bilingual><bilingualism><cognitive function><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><data base><data driven platform><data enclave><data platform><design><designing><developing country><developing nation><disparity in health><economic><empowerment><environmental risk><epigenetically><experience><family support><follow up><follow-up><followed up><followup><geriatric><geriatric medicine><health care access><health care availability><health care service access><health care service availability><health disparity><health related behavior><heavy metal Pb><heavy metal lead><improved><incomes><instrument><internet based platform><internet platform><life course><long-term study><longitudinal aging study><longitudinal aging survey><longitudinal outcome studies><longitudinal research study><longitudinal study in aging><longitudinal study on aging><migration><mobile computing><mobile platform><mobile technology><mortality><old age><older adult><older adulthood><outreach><pandemic><pandemic disease><pandemic effect><pandemic impact><pandemic outcome><pandemic repercussions><physical conditioning><physical health><population based><preservation><primary degenerative dementia><programs><response><retirements><rural area><rural location><rural region><saliva sample><salivary sample><senile dementia of the Alzheimer type><senior citizen><social><social disadvantage><social disparities><social inequality><statistics><trend><usability><user-friendly><virtual><web based platform><web based system><web enabled platform><web platform><web site><website>

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SUSAN M MAJKA

NATIONAL JEWISH HEALTH, DENVER, CO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$946,200

FY 2026

Project Title

Mesenchymal Vascular Progenitor Depletion Promotes Lung Aging and Susceptibility to Emphysema

Grant Number:

5R35HL161238-05

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The overall mission of this research program is to define how pulmonary Mesenchymal Vascular Progenitor Depletion Promotes Lung Aging and Susceptibility to Emphysema. Loss of epithelial progenitor cell function is a unifying factor in accelerated lung aging, and the development of emphysema. However...

Research Terms

<21+ years old><Acceleration><Address><Adult><Adult Human><Aging><Area><Autoregulation><Biologic Models><Biological Models><Blood Vessels><Body Tissues><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cells><Collaborations><Colorado><Development><Dysfunction><Emphysema><Environment><FDA approved><Functional disorder><Goals><Homeostasis><International><Intervention><Intracellular Communication and Signaling><Jewish><Jews><Knowledge><Lung><Lung Diseases><Lung Respiratory System><Mesenchymal><Mission><Model System><Pathway interactions><Physiological Homeostasis><Physiopathology><Predisposition><Process><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Emphysema><Regulation><Research><Senility><Signal Transduction><Signal Transduction Systems><Signaling><Structure><Susceptibility><Therapeutic><Time><Tissues><Universities><Vascular Diseases><Vascular Disorder><Vascular remodeling><adulthood><aged><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging population><angiogenesis><biological signal transduction><blood vessel disorder><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><cigarette smoke exposure><developmental><disease of the lung><disorder of the lung><emphysematous><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><exposure to cigarette smoke><in vitro Model><in vivo><loss of function><lung disorder><lung progenitor><lung stem cell><lung tissue stem cell><lung-specific stem cell><novel><pathophysiology><pathway><population aging><progenitor><progenitor cell based therapy><progenitor cell differentiation><progenitor cell function><progenitor cell pool><progenitor cell population><progenitor cell therapy><progenitor cell treatment><progenitor cells in the lung><progenitor differentiation><progenitor function><progenitor pool><progenitor population><progenitor therapy><progenitor treatment><progenitors in the lung><programs><pulmonary><pulmonary progenitor><pulmonary stem cell><repurposing><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor cell therapy><stem and progenitor differentiation><stem and progenitor function><stem cell based therapy><stem cell differentiation><stem cell function><stem cell mediated therapy><stem cell pool><stem cell population><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem cells in the lung><vascular><vascular dysfunction><vasculopathy>

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Stefano Fusi

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$822,498

FY 2026

Project Title

Dissecting the role of the dentate gyrus microcircuit to improve cognitive discrimination in aging and Alzheimer's Disease

Grant Number:

4R01AG080818-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The dentate gyrus subregion of the hippocampus (DG) has been proposed to play a critical role in ‘pattern separation’, a computational process by which similar experiences are transformed into discrete non- overlapping neural representations. Deficits in pattern separation are found in normal aging ...

Research Terms

<2-photon><21+ years old><AD dementia><AD risk><AD risk factor><Adult><Adult Human><Affect><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease risk><Alzheimers Dementia><Ammon Horn><Benign senescent forgetfulness><Brain region><Cell Survival><Cell Viability><Code><Coding System><Cognitive><Cognitive Discrimination><Cognitive deficits><Computer Models><Computer Simulation><Computer based Simulation><Computerized Models><Connector Neuron><Cornu Ammonis><Dentate Fascia><Discrimination><Environment><Exercise><Fascia Dentata><Genetic><Grant><Gyrus Dentatus><Hippocampus><Image><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intervention><Knowledge><Lateral><Learning><Life><Mammalia><Mammals><Maps><Mediating><Memory><Mice><Mice Mammals><Modeling><Molecular Target><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurons><Optics><Pattern><Physiologic><Physiological><Play><Population><Primary Senile Degenerative Dementia><Process><Proliferating><Regulation><Role><Supporting Cell><Testing><Therapeutic><adulthood><age associated><age associated cognitive impairment><age associated disease><age associated disorder><age associated impairment><age associated memory decline><age associated memory deficit><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related cognitive deficit><age related cognitive disorder><age related cognitive dysfunction><age related cognitive impairment><age related human disease><age related memory dysfunction><age reversal><age specific><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><age-related disease><age-related disorder><age-related impairment><aged mice><aged mouse><aging associated><aging related><aging related cognitive decline><aging reversal><alleviate age related><alleviate aging><alzheimer risk><ameliorating aging><antagonism><antagonist><cognitive defects><computational modeling><computational models><computational simulation><computer based models><computerized modeling><computerized simulation><counter age related><counter aging><counteract age related><counteract aging><declining cognitive functions with aging><density><dentate gyrus><discrimination task><elderly mice><experience><experiment><experimental research><experimental study><experiments><granule cell><hippocampal><imaging><immersive digital environment><immersive environment><immersive virtual environment><immersive virtual reality><improved><in vivo><insight><memory encoding><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><mouse model><murine model><natural aging><nerve stem cell><neural><neural circuit><neural circuitry><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurocircuitry><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><normal aging><normative aging><old mice><optical><optogenetics><pharmacologic><primary degenerative dementia><progenitor and neural stem cells><reverse age><reverse aging><reverse aging effects><reversible aging><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social role><synaptic circuit><synaptic circuitry><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><translational opportunities><translational potential><two-photon><virtual reality environment>

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Rene Hen

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$822,498

FY 2026

Project Title

Dissecting the role of the dentate gyrus microcircuit to improve cognitive discrimination in aging and Alzheimer's Disease

Grant Number:

4R01AG080818-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The dentate gyrus subregion of the hippocampus (DG) has been proposed to play a critical role in ‘pattern separation’, a computational process by which similar experiences are transformed into discrete non- overlapping neural representations. Deficits in pattern separation are found in normal aging ...

Research Terms

<2-photon><21+ years old><AD dementia><AD risk><AD risk factor><Adult><Adult Human><Affect><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease risk><Alzheimers Dementia><Ammon Horn><Benign senescent forgetfulness><Brain region><Cell Survival><Cell Viability><Code><Coding System><Cognitive><Cognitive Discrimination><Cognitive deficits><Computer Models><Computer Simulation><Computer based Simulation><Computerized Models><Connector Neuron><Cornu Ammonis><Dentate Fascia><Discrimination><Environment><Exercise><Fascia Dentata><Genetic><Grant><Gyrus Dentatus><Hippocampus><Image><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intervention><Knowledge><Lateral><Learning><Life><Mammalia><Mammals><Maps><Mediating><Memory><Mice><Mice Mammals><Modeling><Molecular Target><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurons><Optics><Pattern><Physiologic><Physiological><Play><Population><Primary Senile Degenerative Dementia><Process><Proliferating><Regulation><Role><Supporting Cell><Testing><Therapeutic><adulthood><age associated><age associated cognitive impairment><age associated disease><age associated disorder><age associated impairment><age associated memory decline><age associated memory deficit><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related cognitive deficit><age related cognitive disorder><age related cognitive dysfunction><age related cognitive impairment><age related human disease><age related memory dysfunction><age reversal><age specific><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><age-related disease><age-related disorder><age-related impairment><aged mice><aged mouse><aging associated><aging related><aging related cognitive decline><aging reversal><alleviate age related><alleviate aging><alzheimer risk><ameliorating aging><antagonism><antagonist><cognitive defects><computational modeling><computational models><computational simulation><computer based models><computerized modeling><computerized simulation><counter age related><counter aging><counteract age related><counteract aging><declining cognitive functions with aging><density><dentate gyrus><discrimination task><elderly mice><experience><experiment><experimental research><experimental study><experiments><granule cell><hippocampal><imaging><immersive digital environment><immersive environment><immersive virtual environment><immersive virtual reality><improved><in vivo><insight><memory encoding><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><mouse model><murine model><natural aging><nerve stem cell><neural><neural circuit><neural circuitry><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurocircuitry><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><normal aging><normative aging><old mice><optical><optogenetics><pharmacologic><primary degenerative dementia><progenitor and neural stem cells><reverse age><reverse aging><reverse aging effects><reversible aging><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social role><synaptic circuit><synaptic circuitry><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><translational opportunities><translational potential><two-photon><virtual reality environment>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Attila Losonczy

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$822,498

FY 2026

Project Title

Dissecting the role of the dentate gyrus microcircuit to improve cognitive discrimination in aging and Alzheimer's Disease

Grant Number:

4R01AG080818-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The dentate gyrus subregion of the hippocampus (DG) has been proposed to play a critical role in ‘pattern separation’, a computational process by which similar experiences are transformed into discrete non- overlapping neural representations. Deficits in pattern separation are found in normal aging ...

Research Terms

<2-photon><21+ years old><AD dementia><AD risk><AD risk factor><Adult><Adult Human><Affect><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease risk><Alzheimers Dementia><Ammon Horn><Benign senescent forgetfulness><Brain region><Cell Survival><Cell Viability><Code><Coding System><Cognitive><Cognitive Discrimination><Cognitive deficits><Computer Models><Computer Simulation><Computer based Simulation><Computerized Models><Connector Neuron><Cornu Ammonis><Dentate Fascia><Discrimination><Environment><Exercise><Fascia Dentata><Genetic><Grant><Gyrus Dentatus><Hippocampus><Image><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intervention><Knowledge><Lateral><Learning><Life><Mammalia><Mammals><Maps><Mediating><Memory><Mice><Mice Mammals><Modeling><Molecular Target><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Stem Cell><Neurocyte><Neurons><Optics><Pattern><Physiologic><Physiological><Play><Population><Primary Senile Degenerative Dementia><Process><Proliferating><Regulation><Role><Supporting Cell><Testing><Therapeutic><adulthood><age associated><age associated cognitive impairment><age associated disease><age associated disorder><age associated impairment><age associated memory decline><age associated memory deficit><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related cognitive deficit><age related cognitive disorder><age related cognitive dysfunction><age related cognitive impairment><age related human disease><age related memory dysfunction><age reversal><age specific><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><age-related disease><age-related disorder><age-related impairment><aged mice><aged mouse><aging associated><aging related><aging related cognitive decline><aging reversal><alleviate age related><alleviate aging><alzheimer risk><ameliorating aging><antagonism><antagonist><cognitive defects><computational modeling><computational models><computational simulation><computer based models><computerized modeling><computerized simulation><counter age related><counter aging><counteract age related><counteract aging><declining cognitive functions with aging><density><dentate gyrus><discrimination task><elderly mice><experience><experiment><experimental research><experimental study><experiments><granule cell><hippocampal><imaging><immersive digital environment><immersive environment><immersive virtual environment><immersive virtual reality><improved><in vivo><insight><memory encoding><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><mouse model><murine model><natural aging><nerve stem cell><neural><neural circuit><neural circuitry><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurocircuitry><neurogenesis><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><normal aging><normative aging><old mice><optical><optogenetics><pharmacologic><primary degenerative dementia><progenitor and neural stem cells><reverse age><reverse aging><reverse aging effects><reversible aging><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social role><synaptic circuit><synaptic circuitry><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><translational opportunities><translational potential><two-photon><virtual reality environment>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Rebecca G Reed

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$794,992

FY 2026

Project Title

Accelerated Epigenetic Aging as a Mechanism in Lifespan Socioeconomic Effects on Midlife Cognitive Decline

Grant Number:

5R01AG086346-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Progressive cognitive decline including Alzheimer’s Disease and its related dementias (ADRD) does not suddenly occur in later life; it emerges over time, influenced by many mechanisms across the lifespan. Evidence links individual- and, more recently, community-level socioec...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><AD risk><AD risk factor><ADRD><Address><Adult><Adult Human><Affect><Age><Alzheimer risk factor><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Amentia><Attention><Behavior><Biological><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Causality><Childhood><Chronology><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><DNA Methylation><Data><Dementia><Development><Disadvantaged><Disturbance in cognition><Early Diagnosis><Economic Conditions><Economic Income><Economical Conditions><Economical Income><Education><Educational aspects><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epigenetic age><Etiology><Exposure to><Female><Future><Health><Impaired cognition><Income><Individual><Intervention><Knowledge><Life><Link><Mediating><Modeling><Molecular><Neuropsychologies><Neuropsychology><Occupational><Pathway interactions><Pattern><Persons><Phenotype><Prevention><Public Health><Research><Risk><Risk Reduction><Role><SES disparity><Sampling><Shapes><Social Mobility><Socioeconomic Factors><Socioeconomically disadvantaged><Specific qualifier value><Specified><Stress><Testing><Time><accelerated aging><accelerated biological age><accelerated biological aging><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><accumulated exposure><accumulated long-term exposure><adulthood><age acceleration><age associated><age correlated><age dependent><age linked><age related><age related pathways><age specific><ages><aggregate exposure><aging associated mechanism><aging induced epigenetic change><aging mechanism><aging pathway><aging related mechanism><aging related pathways><aging-associated epigenetic change><aging-related epigenetic change><alzheimer risk><biologic><biological age><biological mechanism of age><biological pathways of age><causation><cognitive change><cognitive dysfunction><cognitive function><cognitive loss><cohort><community safety><cumulative exposure><cumulative life exposure><cumulative long-term exposure><dementia risk><develop therapy><developmental><differences in health><disease causation><disparity in health><early detection><epigenetic aging><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic regulation of aging><epigenetically><faster epigenetic aging><faster rates of epigenetic aging><health difference><health disparity><incomes><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><innovate><innovation><innovative><insight><intervention development><later in life><later life><life span><life-course exposure><lifelong exposure><lifespan><lifespan exposure><lifetime exposure><mechanism regulating aging><mechanisms involved in aging><mid life><mid-life><middle age><middle aged><midlife><neighborhood safety><neuropsychologic><pathway><pathway involved in aging><pediatric><rapid epigenetic aging><recruit><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><risk-reducing><social><social role><socio-economic><socio-economic disadvantage><socio-economic disparity><socio-economic factors><socio-economic inequality><socio-economic inequity><socio-economically><socio-economically disadvantaged><socio-economically underprivileged><socioeconomic disadvantage><socioeconomic disparity><socioeconomic inequality><socioeconomic inequity><socioeconomically><socioeconomically underprivileged><socioeconomics><therapy development><totality of exposures><treatment development><treatment strategy><♀>

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Judith E Carroll

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$780,390

FY 2026

Project Title

Patterns of biological, cognitive, and physical aging in cancer survivors and controls and the role of sleep health: Relevance for Alzheimer's Disease and Related Dementias

Grant Number:

5R01AG082348-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract We use a geroscience framework to advance Alzheimer’s disease-related dementias (ADRD) research by establishing how biological aging affects cognitive and physical decline and defining the role of sleep in these relationships. We use the interface of aging and breast cancer in older women f...

Research Terms

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Jeanne Mandelblatt

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$780,390

FY 2026

Project Title

Patterns of biological, cognitive, and physical aging in cancer survivors and controls and the role of sleep health: Relevance for Alzheimer's Disease and Related Dementias

Grant Number:

5R01AG082348-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract We use a geroscience framework to advance Alzheimer’s disease-related dementias (ADRD) research by establishing how biological aging affects cognitive and physical decline and defining the role of sleep in these relationships. We use the interface of aging and breast cancer in older women f...

Research Terms

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Claude Desplan

NEW YORK UNIVERSITY, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$765,297

FY 2026

Project Title

Aging and rejuvenation: An ant model to study the regulation of longevity

Grant Number:

5R01AG058762-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project summary: Ants are social insects that live in colonies of morphologically and physiologically different individuals that are essentially identical genetically, making ants an attractive system to study epigenetic phenomena. Ant colonies contain many workers that perform most tasks but do not...

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DANNY REINBERG

NEW YORK UNIVERSITY, NEW YORK, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$765,297

FY 2026

Project Title

Aging and rejuvenation: An ant model to study the regulation of longevity

Grant Number:

5R01AG058762-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project summary: Ants are social insects that live in colonies of morphologically and physiologically different individuals that are essentially identical genetically, making ants an attractive system to study epigenetic phenomena. Ant colonies contain many workers that perform most tasks but do not...

Research Terms

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CARRIE R MCDONALD

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$720,816

FY 2026

Project Title

BRain Aging and Cognition in Epilepsy (BRACE): A longitudinal investigation of vascular, genetic, and biomarker risk profiles in elderly patients with epilepsy

Grant Number:

5R01NS120976-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Epilepsy is the fourth most common neurological disease, costing the healthcare system approximately $15.5 billion annually and negatively impacting quality of life. The incidence and prevalence of epilepsy peaks over the age of 55—a group that is particularly vulnerable to accelerated cognitive and...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD related dementia><ADRD><APOE><Acceleration><Adult><Adult Human><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><Anti-epileptic><Apo-E><ApoE protein><Apolipoprotein E><Apolipoproteins><Atrophic><Atrophy><Benchmarking><Best Practice Analysis><Bilateral><Biological Markers><Bleeding><Blood><Blood Reticuloendothelial System><Blood Vessels><Brain><Brain Nervous System><Brain Vascular Disorders><Caring><Cerebrospinal Fluid><Cerebrovascular Circulation><Cerebrovascular Disease><Cerebrovascular Disorders><Chronic><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Data><Degenerative Neurologic Disorders><Dementia><Diffusion><Disability prevention><Disease><Disorder><Disturbance in cognition><Drug Therapy><Early Diagnosis><Education><Educational aspects><Encephalon><Epilepsy><Epileptic Seizures><Epileptics><Ethnic Origin><Ethnicity><Executive Dysfunction><Executive Function Deficit><Executive Impairment><Exhibits><Focal Epilepsy><Focal Seizure Disorder><Frontal Lobe Epilepsy><Genetic><Genetic predisposing factor><Genotype><Geography><Goals><Grant><Health Care Costs><Health Care Systems><Health Costs><Hemorrhage><Hypertension><Image><Impaired cognition><Incidence><Individual><Intracranial Vascular Diseases><Intracranial Vascular Disorders><Investigation><Leanness><Life Style><Lifestyle><Link><Localization-Related Epilepsy><Long-term prospective studies><Longitudinal Studies><Longitudinal Surveys><MT-bound tau><Memory><Memory Loss><Modeling><Multi-center studies><Multicenter Studies><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Disorders><Neuropsychologic Tests><Neuropsychological Tests><Neuropsychologies><Neuropsychology><Obesity><Operative Procedures><Operative Surgical Procedures><Partial Epilepsies><Partial Seizure Disorder><Pathogenesis><Pathologic><Pathology><Patient Care><Patient Care Delivery><Patients><Pattern><Pharmacological Treatment><Pharmacotherapy><Population><Prevalence><Preventing disabilities><Primary Senile Degenerative Dementia><Public Health><QOL><Quality of life><Race><Races><Research><Resected><Risk><Risk Factors><Rodent Model><Seizure Disorder><Seizures><Site><Speed><Surgical><Surgical Interventions><Surgical Procedure><Tauopathies><Temporal Lobe Epilepsy><Therapeutic><Thinness><United States><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><White Matter Hyperintensity><aberrant aging><abnormal aging><accelerated aging><accelerated biological age><accelerated biological aging><adiposity><adulthood><adverse consequence><adverse outcome><age acceleration><aged brain><ages><aging associated disease><aging associated disorders><aging brain><aging related disease><aging related disorders><amnestic mild cognitive impairment><anti-epileptic agents><anti-epileptic drugs><benchmark><bio-markers><biologic marker><biomarker><blood flow in brain><blood loss><brain atrophy><brain blood circulation><brain blood flow><brain health><brain vascular disease><brain vascular dysfunction><care for patients><care of patients><caring for patients><cerebral atrophy><cerebral blood flow><cerebral circulation><cerebral spinal fluid><cerebral vascular disease><cerebral vascular dysfunction><cerebrocirculation><cerebrovascular blood flow><cerebrovascular dysfunction><co-morbid><co-morbidity><cognitive dysfunction><cognitive loss><comorbidity><corpulence><cortical atrophy><decline in function><decline in functional status><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><diffused><diffuses><diffusing><diffusions><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><drug intervention><drug treatment><dysfunctional age related change><dysfunctional aging><early detection><elderly patient><epilepsia><epilepsy participant><epilepsy patient><epilepsy subject><epilepsy volunteer><epileptic patient><epileptic subject><epileptogenic><ethnic diversity><ethnically diverse><executive control><executive function><functional decline><functional status decline><genetic risk factor><high blood pressure><high risk group><high risk individual><high risk people><high risk population><human tissue><hyper-phosphorylated tau><hyperphosphorylated tau><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><hypoperfusion><imaging><impaired aging><inherited factor><intracranial vascular dysfunction><investigate longitudinal><life span><life-style factor><lifespan><lifestyle factors><long-term study><longitudinal aging study><longitudinal aging survey><longitudinal investigation><longitudinal outcome studies><longitudinal research><longitudinal research study><longitudinal study in aging><longitudinal study on aging><longitudinal, prospective study><maladaptive aging><malleable risk><medial temporal area><medial temporal lobe><memory decline><mesial temporal area><mesial temporal lobe><microtubule bound tau><microtubule-bound tau><mid life><mid-life><middle age><middle aged><midlife><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><modifiable risk><natural aging><neural imaging><neuro-imaging><neurodegenerative illness><neuroimaging><neurological disease><neurological imaging><neuropathologic tau><neuropathological tau><neuropsychologic><normal aging><normative aging><older adult><older adulthood><older patient><p-tau><p-τ><pathological age related changes><pathological aging><patients with epilepsy><perfusion imaging><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phospho-tau><phospho-τ><phosphorylated tau><post-translational modification of tau><posttranslational modification of tau><prevent><preventing><primary degenerative dementia><processing speed><progression risk><racial><racial background><racial diversity><racial origin><racially diverse><regional atrophy><senile dementia of the Alzheimer type><sex><spinal fluid><study longitudinal><substantia alba><surgery><survey longitudinal><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau phosphorylation><tau posttranslational modification><tau proteinopathy><tau related neurodegeneration><tau-1><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><theories><vascular><vascular risk factor><white matter><white matter injury><τ Proteins><τ phosphorylation>

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Sarah Renee Ocanas

OKLAHOMA MEDICAL RESEARCH FOUNDATION, OKLAHOMA CITY, OK

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$711,479

FY 2026

Project Title

Dissecting Inflammatory and Immune Mechanisms Driving Ovarian Tissue Aging

Grant Number:

1R01AG099844-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Age-related ovarian dysfunction is accompanied by sustained, low-grade inflammation and maladaptive immune activation—characterized by immune cell accumulation, fibrosis, and multinucleated giant cell (MNGC) formation. These pathological features arise before reproductive se...

Research Terms

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Michael B Stout

OKLAHOMA MEDICAL RESEARCH FOUNDATION, OKLAHOMA CITY, OK

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$711,479

FY 2026

Project Title

Dissecting Inflammatory and Immune Mechanisms Driving Ovarian Tissue Aging

Grant Number:

1R01AG099844-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Age-related ovarian dysfunction is accompanied by sustained, low-grade inflammation and maladaptive immune activation—characterized by immune cell accumulation, fibrosis, and multinucleated giant cell (MNGC) formation. These pathological features arise before reproductive se...

Research Terms

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Steven A Belinsky

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$691,990

FY 2026

Project Title

Impact of Macrophage Carbon Load and Epigenetic Aging on Lung Function Decline and Mortality

Grant Number:

5R01ES035421-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/14/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Combustion-emitted particulate matter (CE-PM) is emitted through incomplete combustion of fossil fuels and biomass and is a critical public health and climate change issue in the United States (US) and worldwide. A key feature of CE-PM is the presence of black carbon (BC) cores as universal carriers...

Research Terms

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Shuguang Leng

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$691,990

FY 2026

Project Title

Impact of Macrophage Carbon Load and Epigenetic Aging on Lung Function Decline and Mortality

Grant Number:

5R01ES035421-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/14/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Combustion-emitted particulate matter (CE-PM) is emitted through incomplete combustion of fossil fuels and biomass and is a critical public health and climate change issue in the United States (US) and worldwide. A key feature of CE-PM is the presence of black carbon (BC) cores as universal carriers...

Research Terms

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Rebeca Wong

UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, SAN ANTONIO, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$688,720

FY 2026

Project Title

The Mexican Health Aging Study (MHAS)

Grant Number:

3R01AG018016-20S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/1999

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The Mexican Health and Aging Study (MHAS) is a longitudinal study using a national sample of community-dwelling adults aged 50 and older in urban and rural Mexico. Six waves of data collection over 20 years have been completed. Since its inception, the protocols and survey instruments are highly com...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD related dementia><ADRD><Active Follow-up><Address><Adult><Adult Human><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Ancillary Study><Blood><Blood Reticuloendothelial System><COVID-19><CV-19><Cognitive><Cognitive aging><Cohort Analyses><Cohort Analysis><Collaborations><Communities><Coronavirus Infectious Disease 2019><Country><DNA Methylation><Data><Data Bases><Data Collection><Databases><Developing Countries><Developing Nations><Dimensions><Documentation><Economic Income><Economical Income><Economics><Elderly><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Family><Fostering><Funding><Genetic><Geography><Geriatrics><Goals><Health><Health Care><Health Care Technology><Health Technology><Health and Retirement Study><Health behavior><Income><Individual><Institution><Interdisciplinary Research><Interdisciplinary Study><Investigators><Knowledge><Language><Latin America><Lead><Length><Less-Developed Countries><Less-Developed Nations><Life Cycle><Life Cycle Stages><Link><Longitudinal Studies><Longitudinal Surveys><Mental Health><Mental Hygiene><Mexican><Mexico><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><Participant><Patient Self-Report><Pb element><Peer Review><Physical Function><Population><Position><Positioning Attribute><Prejudice><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Psychological Health><Research><Research Personnel><Research Support><Researchers><Retirement><Running><Rural><Saliva><Sampling><Self-Report><Social Protection><Spanish/English><Structure><Survey Instrument><Surveys><Third-World Countries><Third-World Nations><Under-Developed Countries><Under-Developed Nations><United States><United States National Institutes of Health><Venous><Work><access to health care><accessibility of health care><accessibility to health care><active followup><adulthood><advanced age><aged><bilingual><bilingualism><cognitive function><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><data base><data driven platform><data enclave><data platform><design><designing><developing country><developing nation><disparity in health><economic><empowerment><environmental risk><epigenetically><experience><family support><follow up><follow-up><followed up><followup><geriatric><geriatric medicine><health care access><health care availability><health care service access><health care service availability><health disparity><health related behavior><heavy metal Pb><heavy metal lead><improved><incomes><instrument><internet based platform><internet platform><life course><long-term study><longitudinal aging study><longitudinal aging survey><longitudinal outcome studies><longitudinal research study><longitudinal study in aging><longitudinal study on aging><migration><mobile computing><mobile platform><mobile technology><mortality><old age><older adult><older adulthood><outreach><pandemic><pandemic disease><pandemic effect><pandemic impact><pandemic outcome><pandemic repercussions><physical conditioning><physical health><population based><preservation><primary degenerative dementia><programs><response><retirements><rural area><rural location><rural region><saliva sample><salivary sample><senile dementia of the Alzheimer type><senior citizen><social><social disadvantage><social disparities><social inequality><statistics><trend><usability><user-friendly><virtual><web based platform><web based system><web enabled platform><web platform><web site><website>

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Alip Ghosh

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$685,937

FY 2026

Project Title

Impact of opioid use disorder on mitochondrial dysfunction among antiretroviral therapy-receiving aging people with HIV.

Grant Number:

1R01DA065079-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Use of antiretroviral therapy (ART) has considerably increased life expectancy for people with HIV (PWH) resulting in increased risk of age-related non-AIDS-defining health burden, including inflammaging, a low-grade chronic proinflammatory immune response, among the older population of PWH compared...

Research Terms

<(TNF)-α><3-10C><3-Pyridinecarboxamide><AIDS Virus><AMCF-I><Abscission><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Oxygen><Adenosine><Adenosine Triphosphate><Adenylpyrophosphate><Affect><Age><Aging><Autoregulation><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cells><B-Lymphocytes><B-cell><BCDF><BSF-2><BSF2><Biochemical Process><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood monocyte><CCL20><CCL20 gene><CRG-2><CXCL10><CXCL10 gene><CXCL8><Cachectin><Calcium><Cell Aging><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cells><Cellular Aging><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Cellular Senescence><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Chemokine, CC Motif, Ligand 20><Chronic><Cytotoxic cell><Data><Dinucleoside Phosphates><Edodekin Alfa><Excision><Exodus 1><Extirpation><Fatty Acids><GCP1><General Population><General Public><Generations><Genes><HIV><HIV Seronegativities><HIV Seronegativity><HIV and aging><HIV associated aging><HIV individuals><HIV infected individuals><HIV infected persons><HIV latency><HIV negative><HIV people><HIV positive individuals><HIV positive people><HIV related aging><HPGF><HTLV-III Seronegativities><HTLV-III Seronegativity><Health><Hepatocyte-Stimulating Factor><History><Homeostasis><Human Immunodeficiency Viruses><Hybridoma Growth Factor><IFI10><IFN-Gamma><IFN-beta 2><IFN-g><IFN-γ><IFNB2><IFNG><IFNγ><IL-12><IL-15><IL-6><IL-8><IL12><IL15><IL15 Protein><IL6 Protein><IL8><IL8 gene><INP10><IP-10><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune Interferon><Immune Markers><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immune system><Immunes><Immunologic Diseases><Immunologic Markers><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Individual><Inflammaging><Inflammatory><Interferon Gamma><Interferon Type II><Interleukin-12><Interleukin-15><Interleukin-15 Precursor><Interleukin-6><Intermediary Metabolism><K lymphocyte><K60><Knowledge><LARC><LAV-HTLV-III><Length><Life Expectancy><Lymphadenopathy-Associated Virus><MGC9721><MGI-2><MIP-1><MIP3A><MOB-1><Macrophage><Macrophage Inflammatory Protein 3-Alpha><Macrophage Inflammatory Protein-1><Macrophage-Derived TNF><Maintenance><Marrow monocyte><Measures><Mediating><Membrane Potentials><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondria><Molecular><Molecular Analysis><Molecular Target><Monocyte-Derived TNF><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><NADH><NK Cells><NKSF><Natural Killer Cell Stimulatory Factor><Natural Killer Cells><Network Analysis><Niacinamide><Nicotinamide><Nicotinamidum><Nicotinic acid amide><Nicotylamide><Older Population><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Organelles><Outcome><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxygen Radicals><PBMC><PLWH><PWH><Pathway Analysis><Pathway interactions><Pellagra-Preventing Factor><Peripheral Blood Mononuclear Cell><Persons><Physiological Homeostasis><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Pro-Oxidants><Process><Production><Publishing><Race><Races><Reactive Oxygen Species><Recording of previous events><Removal><Replicative Senescence><Reporting><Resting Potentials><Reticuloendothelial System, Serum, Plasma><Risk><Role><SCYA20><SCYB10><SCYB8><Sampling><Subcellular Process><Superoxide Anion><Superoxide Radical><Superoxides><Surgical Removal><Surrogate Markers><T-Cells><T-Lymphocyte><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><TSG-1><Testing><Transmembrane Potentials><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Virus-HIV><Vitamin B 3><Vitamin B3><Vitamin PP><Vulnerable Populations><age associated><age correlated><age dependent><age linked><age related><age specific><age-related inflammation><ages><aging associated inflammation><aging biological marker><aging biomarker><aging marker><aging people with HIV><aging population with HIV><aging with HIV><aging with human immunodeficiency virus><antiretroviral therapy><antiretroviral treatment><asymptomatic HIV infection><b-ENAP><biological adaptation to stress><biological age><chronic HIV infection><cofactor><dihydronicotinamide><dinucleotide><exhaustion><experiment><experimental research><experimental study><experiments><gIP-10><histories><host response><immune function><immune senescence><immune system response><immune-based biomarkers><immunological biomarkers><immunological markers><immunoresponse><immunosenescence><improved><improved outcome><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><inflamm-ageing><inflamm-aging><inflammation associated with aging><inflammation marker><inflammatory marker><interferon beta 2><lFN-Gamma><latent HIV infection><mitochondrial><mitochondrial dysfunction><mitochondrial membrane><monocyte><multiple substance use><multisubstance use><older groups><older individuals><older person><opiate consumption><opiate drug use><opiate intake><opiate use><opiate use disorder><opioid addiction><opioid consumption><opioid dependence><opioid dependent><opioid drug use><opioid intake><opioid use><opioid use disorder><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><phenotypic biomarker><phenotypic marker><poly substance use><polysubstance use><prevent><preventing><racial><racial background><racial origin><reactioncrisis><replicative aging><resection><riboside><scRNA sequencing><scRNA-seq><senescence><senescent><sex><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stress response><stressreaction><surrogate bio-markers><surrogate biomarkers><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic outcome><therapeutic target><therapy outcome><thymus derived lymphocyte><transcriptomics><vulnerable group><vulnerable individual><vulnerable people>

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Shyamasundaran Kottilil

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$685,937

FY 2026

Project Title

Impact of opioid use disorder on mitochondrial dysfunction among antiretroviral therapy-receiving aging people with HIV.

Grant Number:

1R01DA065079-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Use of antiretroviral therapy (ART) has considerably increased life expectancy for people with HIV (PWH) resulting in increased risk of age-related non-AIDS-defining health burden, including inflammaging, a low-grade chronic proinflammatory immune response, among the older population of PWH compared...

Research Terms

<(TNF)-α><3-10C><3-Pyridinecarboxamide><AIDS Virus><AMCF-I><Abscission><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Oxygen><Adenosine><Adenosine Triphosphate><Adenylpyrophosphate><Affect><Age><Aging><Autoregulation><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cells><B-Lymphocytes><B-cell><BCDF><BSF-2><BSF2><Biochemical Process><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood monocyte><CCL20><CCL20 gene><CRG-2><CXCL10><CXCL10 gene><CXCL8><Cachectin><Calcium><Cell Aging><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cells><Cellular Aging><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Cellular Senescence><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Chemokine, CC Motif, Ligand 20><Chronic><Cytotoxic cell><Data><Dinucleoside Phosphates><Edodekin Alfa><Excision><Exodus 1><Extirpation><Fatty Acids><GCP1><General Population><General Public><Generations><Genes><HIV><HIV Seronegativities><HIV Seronegativity><HIV and aging><HIV associated aging><HIV individuals><HIV infected individuals><HIV infected persons><HIV latency><HIV negative><HIV people><HIV positive individuals><HIV positive people><HIV related aging><HPGF><HTLV-III Seronegativities><HTLV-III Seronegativity><Health><Hepatocyte-Stimulating Factor><History><Homeostasis><Human Immunodeficiency Viruses><Hybridoma Growth Factor><IFI10><IFN-Gamma><IFN-beta 2><IFN-g><IFN-γ><IFNB2><IFNG><IFNγ><IL-12><IL-15><IL-6><IL-8><IL12><IL15><IL15 Protein><IL6 Protein><IL8><IL8 gene><INP10><IP-10><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune Interferon><Immune Markers><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immune system><Immunes><Immunologic Diseases><Immunologic Markers><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Individual><Inflammaging><Inflammatory><Interferon Gamma><Interferon Type II><Interleukin-12><Interleukin-15><Interleukin-15 Precursor><Interleukin-6><Intermediary Metabolism><K lymphocyte><K60><Knowledge><LARC><LAV-HTLV-III><Length><Life Expectancy><Lymphadenopathy-Associated Virus><MGC9721><MGI-2><MIP-1><MIP3A><MOB-1><Macrophage><Macrophage Inflammatory Protein 3-Alpha><Macrophage Inflammatory Protein-1><Macrophage-Derived TNF><Maintenance><Marrow monocyte><Measures><Mediating><Membrane Potentials><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondria><Molecular><Molecular Analysis><Molecular Target><Monocyte-Derived TNF><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><NADH><NK Cells><NKSF><Natural Killer Cell Stimulatory Factor><Natural Killer Cells><Network Analysis><Niacinamide><Nicotinamide><Nicotinamidum><Nicotinic acid amide><Nicotylamide><Older Population><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Organelles><Outcome><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxygen Radicals><PBMC><PLWH><PWH><Pathway Analysis><Pathway interactions><Pellagra-Preventing Factor><Peripheral Blood Mononuclear Cell><Persons><Physiological Homeostasis><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Pro-Oxidants><Process><Production><Publishing><Race><Races><Reactive Oxygen Species><Recording of previous events><Removal><Replicative Senescence><Reporting><Resting Potentials><Reticuloendothelial System, Serum, Plasma><Risk><Role><SCYA20><SCYB10><SCYB8><Sampling><Subcellular Process><Superoxide Anion><Superoxide Radical><Superoxides><Surgical Removal><Surrogate Markers><T-Cells><T-Lymphocyte><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><TSG-1><Testing><Transmembrane Potentials><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Virus-HIV><Vitamin B 3><Vitamin B3><Vitamin PP><Vulnerable Populations><age associated><age correlated><age dependent><age linked><age related><age specific><age-related inflammation><ages><aging associated inflammation><aging biological marker><aging biomarker><aging marker><aging people with HIV><aging population with HIV><aging with HIV><aging with human immunodeficiency virus><antiretroviral therapy><antiretroviral treatment><asymptomatic HIV infection><b-ENAP><biological adaptation to stress><biological age><chronic HIV infection><cofactor><dihydronicotinamide><dinucleotide><exhaustion><experiment><experimental research><experimental study><experiments><gIP-10><histories><host response><immune function><immune senescence><immune system response><immune-based biomarkers><immunological biomarkers><immunological markers><immunoresponse><immunosenescence><improved><improved outcome><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><inflamm-ageing><inflamm-aging><inflammation associated with aging><inflammation marker><inflammatory marker><interferon beta 2><lFN-Gamma><latent HIV infection><mitochondrial><mitochondrial dysfunction><mitochondrial membrane><monocyte><multiple substance use><multisubstance use><older groups><older individuals><older person><opiate consumption><opiate drug use><opiate intake><opiate use><opiate use disorder><opioid addiction><opioid consumption><opioid dependence><opioid dependent><opioid drug use><opioid intake><opioid use><opioid use disorder><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><phenotypic biomarker><phenotypic marker><poly substance use><polysubstance use><prevent><preventing><racial><racial background><racial origin><reactioncrisis><replicative aging><resection><riboside><scRNA sequencing><scRNA-seq><senescence><senescent><sex><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stress response><stressreaction><surrogate bio-markers><surrogate biomarkers><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic outcome><therapeutic target><therapy outcome><thymus derived lymphocyte><transcriptomics><vulnerable group><vulnerable individual><vulnerable people>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

SUSAN M MAJKA

NATIONAL JEWISH HEALTH, DENVER, CO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$685,103

FY 2026

Project Title

Loss of progenitor function accelerates lung aging

Grant Number:

5R01AG073317-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Aging is associated with loss of lung structure and declining function. Emphysematous loss of tissue structure is exacerbated by vasculopathy, which increases susceptibility to lung disease, and limits survival. We have previously demonstrated that the structure and function of the lung microvascula...

Research Terms

<21+ years old><5 year old><5 years of age><Acceleration><Address><Adult><Adult Human><Age><Aging><Alveolar Lavage Fluids><Assay><Autoregulation><Bioassay><Biological Assay><Biology><Blood Plasma><Blood Vessels><Body Tissues><Bronchial Lavage Fluid><COPD><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication><Cell Components><Cell Count><Cell Function><Cell Interaction><Cell Number><Cell Physiology><Cell Process><Cell Structure><Cell-to-Cell Interaction><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Structures><Characteristics><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Chronic lung disease><Co-culture><Cocultivation><Coculture><Coculture Techniques><Coupled><Data><Development><Disease><Disorder><Distal><Dysfunction><Emphysema><Endothelium><Female><Functional disorder><Goals><Heart Vascular><Histologic><Histologically><Homeostasis><Human><IL-13><IL13><Immune><Immune infiltrates><Immunes><Impairment><In Vitro><In vivo analysis><Inflammation><Inflammatory><Inflammatory Infiltrate><Interleukin-13><Knowledge><Link><Lung><Lung Diseases><Lung Lavage Fluid><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lymphoid Cell><Maintenance><Medial><Mesenchymal><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Oxidation-Reduction><Patients><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Physiology><Physiopathology><Plasma><Plasma Serum><Play><Predisposition><Premature Aging><Premature aging syndrome><Process><Progenitor Cells><Prognosis><Proteins><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Emphysema><Redox><Reticuloendothelial System, Serum, Plasma><Sampling><Senility><Smoker><Smoking><Stromal Cells><Structure><Structure of parenchyma of lung><Subcellular Process><Subgroup><Susceptibility><Testing><Tissues><Vascular Diseases><Vascular Disorder><Vascular remodeling><Work><accelerated aging><accelerated biological age><accelerated biological aging><adulthood><age 5><age 5 years><age acceleration><age associated decline><age dependent decline><age related decline><aged><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><ages><aging population><angiogenesis><blood vessel disorder><chronic obstructive pulmonary disorder><chronic pulmonary disease><cigarette smoke exposure><circulatory system><cytokine><decline with age><developmental><disease of the lung><disorder of the lung><elderly mice><emphysematous><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><exhaustion><exposure to cigarette smoke><five year old><five years of age><human model><immune cell infiltrate><in vivo><in vivo evaluation><in vivo testing><knock-down><knockdown><lung disorder><lung function><lymphocyte precursor><lymphocyte progenitor><lymphocyte stem cell><lymphoid precursor><lymphoid progenitors><lymphoid stem cell><male><model of human><mouse model><murine model><novel><old mice><oxidation reduction reaction><pathophysiology><population aging><progenitor><progenitor aging><progenitor cell aging><progenitor cell function><progenitor cell pool><progenitor cell population><progenitor function><progenitor pool><progenitor population><pulmonary><pulmonary function><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><spheroids><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor function><stem cell aging><stem cell function><stem cell pool><stem cell population><stem cells><transcriptomics><vascular><vascular dysfunction><vasculopathy><♀><♂>

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Richard Lee Reinhardt

NATIONAL JEWISH HEALTH, DENVER, CO

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$685,103

FY 2026

Project Title

Loss of progenitor function accelerates lung aging

Grant Number:

5R01AG073317-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Aging is associated with loss of lung structure and declining function. Emphysematous loss of tissue structure is exacerbated by vasculopathy, which increases susceptibility to lung disease, and limits survival. We have previously demonstrated that the structure and function of the lung microvascula...

Research Terms

<21+ years old><5 year old><5 years of age><Acceleration><Address><Adult><Adult Human><Age><Aging><Alveolar Lavage Fluids><Assay><Autoregulation><Bioassay><Biological Assay><Biology><Blood Plasma><Blood Vessels><Body Tissues><Bronchial Lavage Fluid><COPD><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Body><Cell Communication><Cell Components><Cell Count><Cell Function><Cell Interaction><Cell Number><Cell Physiology><Cell Process><Cell Structure><Cell-to-Cell Interaction><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Structures><Characteristics><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Chronic lung disease><Co-culture><Cocultivation><Coculture><Coculture Techniques><Coupled><Data><Development><Disease><Disorder><Distal><Dysfunction><Emphysema><Endothelium><Female><Functional disorder><Goals><Heart Vascular><Histologic><Histologically><Homeostasis><Human><IL-13><IL13><Immune><Immune infiltrates><Immunes><Impairment><In Vitro><In vivo analysis><Inflammation><Inflammatory><Inflammatory Infiltrate><Interleukin-13><Knowledge><Link><Lung><Lung Diseases><Lung Lavage Fluid><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lymphoid Cell><Maintenance><Medial><Mesenchymal><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Oxidation-Reduction><Patients><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Physiology><Physiopathology><Plasma><Plasma Serum><Play><Predisposition><Premature Aging><Premature aging syndrome><Process><Progenitor Cells><Prognosis><Proteins><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Emphysema><Redox><Reticuloendothelial System, Serum, Plasma><Sampling><Senility><Smoker><Smoking><Stromal Cells><Structure><Structure of parenchyma of lung><Subcellular Process><Subgroup><Susceptibility><Testing><Tissues><Vascular Diseases><Vascular Disorder><Vascular remodeling><Work><accelerated aging><accelerated biological age><accelerated biological aging><adulthood><age 5><age 5 years><age acceleration><age associated decline><age dependent decline><age related decline><aged><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><ages><aging population><angiogenesis><blood vessel disorder><chronic obstructive pulmonary disorder><chronic pulmonary disease><cigarette smoke exposure><circulatory system><cytokine><decline with age><developmental><disease of the lung><disorder of the lung><elderly mice><emphysematous><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><exhaustion><exposure to cigarette smoke><five year old><five years of age><human model><immune cell infiltrate><in vivo><in vivo evaluation><in vivo testing><knock-down><knockdown><lung disorder><lung function><lymphocyte precursor><lymphocyte progenitor><lymphocyte stem cell><lymphoid precursor><lymphoid progenitors><lymphoid stem cell><male><model of human><mouse model><murine model><novel><old mice><oxidation reduction reaction><pathophysiology><population aging><progenitor><progenitor aging><progenitor cell aging><progenitor cell function><progenitor cell pool><progenitor cell population><progenitor function><progenitor pool><progenitor population><pulmonary><pulmonary function><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><spheroids><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor function><stem cell aging><stem cell function><stem cell pool><stem cell population><stem cells><transcriptomics><vascular><vascular dysfunction><vasculopathy><♀><♂>

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Haobo Li

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$677,685

FY 2026

Project Title

The Role of SALTe1 in Vascular Aging and Heart Failure With Preserved Ejection Fraction

Grant Number:

5R01HL169272-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary / Abstract Heart Failure (HF) is a major cause of death in the United States. Advanced age is a major risk factor for HF and overall cardiovascular disease. HF with preserved ejection fraction (HFpEF) is the predominant form in older adults, accounting for more than 50% of HF cases. Effecti...

Research Terms

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Lee A Lindquist

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$670,904

FY 2026

Project Title

Implementation of Aging-in-Place Services for Older Adults with Alzheimer's Dementia

Grant Number:

1R01AG091323-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

We aim to continue to longitudinally follow our current cohort study [R01AG058777] (n=293, 94.5% retention rate) to better understand how older adult aging-in-place/long term care (AIP/LTC) decision making, and implementation change over time - impacted by age-related changes (e.g., cognition, funct...

Research Terms

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ADAM C PUCHE

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$649,766

FY 2026

Project Title

HCN Channels Mediate Olfactory Dysfunction in Aging and Neurological Disease

Grant Number:

1R01AG092405-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Olfaction frequently declines during aging and in neurological diseases including Alzheimer’s disease. Hyperpolarization- activated cyclic nucleotide-gated cation (HCN) channels (isoforms 1-4) generate the Ih conductance, playing controlling roles in neuronal excitability an...

Research Terms

<21+ years old><AD dementia><AD model><Adult><Adult Human><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimers Dementia><Animal Disease Models><Animal Model><Animal Models and Related Studies><BCNG1><Behavior><Behavioral><Body Tissues><Brain Cyclic-Nucleotide Gated 1><Calcium><Categories><Cations><Cell Body><Cells><Characteristics><Cognitive><Cognitive deficits><Connector Neuron><Cyclic Nucleotides><Cyclicity><Data><Degenerative Neurologic Disorders><Disease><Disorder><Down-Regulation><Dysfunction><Electrophysiology><Electrophysiology (science)><Elements><Exhibits><Functional disorder><Genes><Genetic><HCN1><HCN1 gene><HCN4><HCN4 gene><Health><Hyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 1><Hyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 4><Image><Impairment><In Vitro><Individual><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Investigation><Isoforms><Link><Maps><Mediating><Messenger RNA><Mice><Mice Mammals><Molecular><Morphology><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Disorders><Neurons><Neurophysiology / Electrophysiology><Odors><Olfaction><Olfactory Pathways><Olfactory dysfunction><Olfactory system><Output><Pace Stimulators><Pacemakers><Pattern><Performance><Periodicals><Periodicity><Phenotype><Physiopathology><Play><Potassium Channel, Voltage-Gated, Brain, 1><Primary Senile Degenerative Dementia><Protein Isoforms><Proteins><Regulation><Rejuvenation><Reporting><Rhythmicity><Role><Sensory><Smell><Smell Perception><Subgroup><Testing><Tissues><Upregulation><Viral><adult youth><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged brain><ages><aging brain><alzheimer model><antagonism><antagonist><cell type><cognitive defects><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><electrophysiological><excitatory neuron><experiment><experimental research><experimental study><experiments><familial AD><familial Alzheimer><familial Alzheimer disease><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><imaging><in vivo><juvenile animal><knock-down><knockdown><mRNA><mitral cell><model of animal><multi-photon><natural aging><neural><neural network><neurodegenerative illness><neurological disease><neuronal><neuronal excitability><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><normal aging><normative aging><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><odor perception><olfactory bulb><olfactory circuitry><olfactory circuits><olfactory impairment><olfactory perception><overexpress><overexpression><pathophysiology><periodic><periodical><pharmacologic><primary degenerative dementia><protein expression><restoration><selective expression><selectively expressed><senile dementia of the Alzheimer type><social role><therapeutic target><young adult><young adult age><young adulthood><young animal><younger age>

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Fuwen Zhou

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$649,766

FY 2026

Project Title

HCN Channels Mediate Olfactory Dysfunction in Aging and Neurological Disease

Grant Number:

1R01AG092405-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Olfaction frequently declines during aging and in neurological diseases including Alzheimer’s disease. Hyperpolarization- activated cyclic nucleotide-gated cation (HCN) channels (isoforms 1-4) generate the Ih conductance, playing controlling roles in neuronal excitability an...

Research Terms

<21+ years old><AD dementia><AD model><Adult><Adult Human><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimers Dementia><Animal Disease Models><Animal Model><Animal Models and Related Studies><BCNG1><Behavior><Behavioral><Body Tissues><Brain Cyclic-Nucleotide Gated 1><Calcium><Categories><Cations><Cell Body><Cells><Characteristics><Cognitive><Cognitive deficits><Connector Neuron><Cyclic Nucleotides><Cyclicity><Data><Degenerative Neurologic Disorders><Disease><Disorder><Down-Regulation><Dysfunction><Electrophysiology><Electrophysiology (science)><Elements><Exhibits><Functional disorder><Genes><Genetic><HCN1><HCN1 gene><HCN4><HCN4 gene><Health><Hyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 1><Hyperpolarization-Activated Cyclic Nucleotide-Gated Potassium Channel 4><Image><Impairment><In Vitro><Individual><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Investigation><Isoforms><Link><Maps><Mediating><Messenger RNA><Mice><Mice Mammals><Molecular><Morphology><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Disorders><Neurons><Neurophysiology / Electrophysiology><Odors><Olfaction><Olfactory Pathways><Olfactory dysfunction><Olfactory system><Output><Pace Stimulators><Pacemakers><Pattern><Performance><Periodicals><Periodicity><Phenotype><Physiopathology><Play><Potassium Channel, Voltage-Gated, Brain, 1><Primary Senile Degenerative Dementia><Protein Isoforms><Proteins><Regulation><Rejuvenation><Reporting><Rhythmicity><Role><Sensory><Smell><Smell Perception><Subgroup><Testing><Tissues><Upregulation><Viral><adult youth><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged brain><ages><aging brain><alzheimer model><antagonism><antagonist><cell type><cognitive defects><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><electrophysiological><excitatory neuron><experiment><experimental research><experimental study><experiments><familial AD><familial Alzheimer><familial Alzheimer disease><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><imaging><in vivo><juvenile animal><knock-down><knockdown><mRNA><mitral cell><model of animal><multi-photon><natural aging><neural><neural network><neurodegenerative illness><neurological disease><neuronal><neuronal excitability><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><normal aging><normative aging><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><odor perception><olfactory bulb><olfactory circuitry><olfactory circuits><olfactory impairment><olfactory perception><overexpress><overexpression><pathophysiology><periodic><periodical><pharmacologic><primary degenerative dementia><protein expression><restoration><selective expression><selectively expressed><senile dementia of the Alzheimer type><social role><therapeutic target><young adult><young adult age><young adulthood><young animal><younger age>

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GARY J FISHER

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$627,577

FY 2026

Project Title

The impact of the dermal ECM microenvironment on cutaneous aging and cancer

Grant Number:

5R01AG081805-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/28/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT The major goal of this grant application is to determine the molecular mechanisms by which age-related elevation of matrix metalloproteinase-1 (MMP1) in dermal fibroblasts creates a microenvironment that promotes the aging process and age-related skin pathologies, including cancer. Aging af...

Research Terms

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TaiHao Quan

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$627,577

FY 2026

Project Title

The impact of the dermal ECM microenvironment on cutaneous aging and cancer

Grant Number:

5R01AG081805-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

2/28/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT The major goal of this grant application is to determine the molecular mechanisms by which age-related elevation of matrix metalloproteinase-1 (MMP1) in dermal fibroblasts creates a microenvironment that promotes the aging process and age-related skin pathologies, including cancer. Aging af...

Research Terms

View Full Project Details on NIH Reporter

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Xiaolei Xu

MAYO CLINIC ROCHESTER, ROCHESTER, MN

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$617,782

FY 2026

Project Title

Epicardial remodeling in cardiomyopathy and cardiac aging

Grant Number:

5R01HL107304-14

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2011

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Epicardium is a mesothelium layer that covers the surface of a vertebrate heart. Epicardial activation, which is reflected by increased expression of certain epicardial genes in the whole epicardium, has been reported to play a vital role during heart regeneration. However, whether e...

Research Terms

<21+ years old><ATF-3><ATF3><Acceleration><Adult><Adult Human><African><Antibody-drug conjugates><BAG3><BAG3 gene><BCL2-Associated Athanogene 3><Basal Transcription Factor><Basal transcription factor genes><Brachydanio rerio><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiomyopathies><Cell Aging><Cell Body><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Danio rerio><Data><Epicardium><Epithelium><Event><Gene Activation><Gene Expression><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Screening><Genetic study><Heart><Heart Diseases><Human><Killifishes><Lineage Tracing><Mesenchymal><Mesothelium><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><Pathologic><Patients><Play><Population><Process><Rejuvenation><Replicative Senescence><Reporting><Role><Series><Surface><Testing><Therapeutic><Transcription Factor Proto-Oncogene><Transcription factor genes><Translating><Zebra Danio><Zebra Fish><Zebrafish><activating transcription factor 3><adulthood><aged><aging associated><aging prevention><aging process><aging related><anti aging><anti geronic><antiaging><cardiac aging><cardiac regeneration><cardioprotectant><cardioprotection><cardioprotective><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><differential expression><differentially expressed><experiment><experimental research><experimental study><experiments><fatty acid-binding proteins><glycoprotein NMB><gpNMB><heart aging><heart disorder><heart regeneration><life span><lifespan><molecular biomarker><molecular marker><myocardium disease><myocardium disorder><novel><prevent age related><prevent aging><promoter><promotor><replicative aging><social role><suppress aging><therapeutic target><transcription factor><transcriptional differences>

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SATORU EGUCHI

ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER, PHOENIX, AZ

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$608,992

FY 2026

Project Title

Roles of aging and cellular senescence in the development of intracranial aneurysm rupture

Grant Number:

5R01AG077780-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Clinical studies have consistently shown a strong association between aging and increased risk for intracranial aneurysm rupture. Aging has traditionally been considered a non-modifiable risk factor. However, it is becoming evident that some of the biological changes associated with ...

Research Terms

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TOMOKI HASHIMOTO

ST. JOSEPH'S HOSPITAL AND MEDICAL CENTER, PHOENIX, AZ

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$608,992

FY 2026

Project Title

Roles of aging and cellular senescence in the development of intracranial aneurysm rupture

Grant Number:

5R01AG077780-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Clinical studies have consistently shown a strong association between aging and increased risk for intracranial aneurysm rupture. Aging has traditionally been considered a non-modifiable risk factor. However, it is becoming evident that some of the biological changes associated with ...

Research Terms

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VINCENT L. CRYNS

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$599,465

FY 2026

Project Title

The regulation of cancer and aging by methionine

Grant Number:

5R01AG084156-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Age-related diseases, including cancer, are the major causes of morbidity and mortality in Western society. While cancer in the genetically heterogeneous human population primarily occurs in the aged, cancer research to-date has primarily utilized young, inbred animals. As the effec...

Research Terms

<21+ years old><4T1><ATP-protein phosphotransferase><Address><Ademetionine><AdoMet><Adult><Adult Human><Affect><Age><Age related pathologies><Aging><Amino Acids><Anabolism><Animal Cancer Model><Animals><Biological><Breast Cancer><Breast Cancer Cell><Breast Cancer Model><Breast Carcinoma><Breast Neoplasms><Breast Tumors><Breast tumor model><Cancer Treatment><Cancers><Cell Body><Cell Culture Techniques><Cell model><Cells><Cellular model><Common Rat Strains><DNA Methylation><DNA Methyltransferase><DNA Modification><DNA Modification Methylases><DNA Modification Methyltransferases><DNA Modification Process><DNA-Methyltransferases><Dependence><Development><Dietary Component><Dietary Intervention><Dietary Proteins><Dnmt><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Frequencies><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><Genetic Transcription><Health><Health Benefit><Heterograft><Heterologous Transplantation><High Prevalence><Host Factor><Host Factor Protein><Human><Immunodeficient Mouse><Inbred Strain><Inbreeding><Increase lifespan><Individual><Integration Host Factors><Intermediary Metabolism><Intervention><Kinase Family Gene><Knowledge><Length of Life><Link><Longevity><Maintenance><Malignant Breast Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mammary Cancer><Mammary Carcinoma><Mammary Neoplasms><Maps><Mediating><Mediator><Metabolic><Metabolic Processes><Metabolism><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Metastatic breast cancer><Methionine><Methionine Metabolism><Methionine Metabolism Pathway><Mice><Mice Mammals><Modeling><Modern Man><Modification Methylases><Molecular><Morbidity><Mouse Strains><Murine><Mus><Neoplasm Metastasis><Normal Tissue><Normal tissue morphology><Nutrition Interventions><Nutritional Interventions><Oncogenesis><PDX model><Pathway interactions><Patient derived xenograft><Persons><Phenotype><Plant-Based Diet><Play><Population><Prevention><Property><Protein Kinase><RNA Expression><Rat><Rats Mammals><Rattus><Regulation><Research><Resistance><Rodent><Rodentia><Rodents Mammals><Role><S-Adenosylhomocysteine><S-Adenosylmethionine><S-adenosyl methionine><S-adenosyl-methionine><SAMe><Secondary Neoplasm><Secondary Tumor><Site-Directed Mutagenesis><Site-Specific DNA-methyltransferase><Site-Specific Mutagenesis><Societies><Stem Cell like><Targeted DNA Modification><Targeted Modification><Techniques><Testing><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Tumor Tissue><Vegan Diet><Work><Xenograft><Xenograft procedure><Xenotransplantation><adulthood><age associated><age associated disease><age associated disorder><age associated effects><age associated impairment><age associated pathologies><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age dependent pathologies><age effect><age induced pathologies><age linked><age related><age related effects><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><aged><aged mice><aged mouse><ages><aging associated><aging associated pathologies><aging delay><aging dependent pathologies><aging effect><aging induced pathologies><aging pathologies><aging process><aging related><aging related pathologies><aminoacid><analyze gene expression><anti-cancer><anti-cancer research><anti-cancer therapy><anti-tumor effect><antitumor effect><attenuate aging><biologic><biosynthesis><boost longevity><breast tumor cell><cancer initiation><cancer metastasis><cancer progression><cancer research><cancer therapy><cancer-directed therapy><cell culture><cell cultures><decelerate aging><delay age related><developmental><diet intervention><diet rich in plants><dietary><dietary restriction><elderly mice><elongating the lifespan><enhance longevity><epigenetic profiling><epigenetically><epigenome><experiment><experimental research><experimental study><experiments><extend life span><extend lifespan><extend longevity><foster longevity><gene expression analysis><gene expression assay><genetic approach><genetic strategy><geroprotectant><geroprotection><geroprotective><geroprotector><glycogen synthase a kinase><healthspan><healthy aging><healthy human aging><healthy life span><histone H3 methyltransferase><histone methylase><histone methylation><histone methyltransferase><histone modification><hydroxyalkyl protein kinase><impact of age><improve lifespan><improve longevity><improved><in vivo><influence of age><insight><interest><intervention enhancing longevity><intervention to extend lifespan><intervention to improve lifespan><intervention to increase longevity><intervention to prolong lifespan><intervention to promote longevity><juvenile animal><life span><lifespan><lifespan extending intervention><lifespan extending therapies><lifespan extension><lifespan improving intervention><lifespan increasing intervention><lifespan increasing therapies><lifespan intervention><lifespan prolonging interventions><lifespan promoting intervention><longevity boosting intervention><longevity extending intervention><longevity intervention><longevity promoting intervention><longevity therapy><longevity treatment><malignancy><malignant breast tumor><mammary cancer model><mammary tumor><mammary tumor model><metabolic phenotype><metabotype><metastatic breast tumor><metastatic mammary cancer><metastatic mammary tumor><model organism><mortality><mouse model><multidisciplinary><murine model><mutant><neoplasm progression><neoplasm/cancer><neoplastic progression><novel><old mice><older women><pathway><patient derived xenograft model><pause aging><pharmacologic><phosphorylase b kinase kinase><plant diet><plant focused diet><plant rich diet><plant-centered diet><postpone age related><prevent><preventing><pro-aging><progenitor capacity><progenitor cell like><progenitor-like><progeronic><prolong lifespan><prolong longevity><promote aging><promote lifespan><promote longevity><resistant><response><restricted diet><retards aging><self-renew><self-renewal><sensor><slow aging><slow down aging><slow the rate of aging><social role><stem cell characteristics><stem-like><stemness><strategy to enhance longevity><strategy to promote longevity><support longevity><transcriptional profiling><tumor><tumor cell metastasis><tumor growth><tumor initiation><tumor progression><tumorigenesis><vegan><veganism><xeno-transplant><xeno-transplantation><young animal>

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JOHN M DENU

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$599,465

FY 2026

Project Title

The regulation of cancer and aging by methionine

Grant Number:

5R01AG084156-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Age-related diseases, including cancer, are the major causes of morbidity and mortality in Western society. While cancer in the genetically heterogeneous human population primarily occurs in the aged, cancer research to-date has primarily utilized young, inbred animals. As the effec...

Research Terms

<21+ years old><4T1><ATP-protein phosphotransferase><Address><Ademetionine><AdoMet><Adult><Adult Human><Affect><Age><Age related pathologies><Aging><Amino Acids><Anabolism><Animal Cancer Model><Animals><Biological><Breast Cancer><Breast Cancer Cell><Breast Cancer Model><Breast Carcinoma><Breast Neoplasms><Breast Tumors><Breast tumor model><Cancer Treatment><Cancers><Cell Body><Cell Culture Techniques><Cell model><Cells><Cellular model><Common Rat Strains><DNA Methylation><DNA Methyltransferase><DNA Modification><DNA Modification Methylases><DNA Modification Methyltransferases><DNA Modification Process><DNA-Methyltransferases><Dependence><Development><Dietary Component><Dietary Intervention><Dietary Proteins><Dnmt><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Frequencies><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><Genetic Transcription><Health><Health Benefit><Heterograft><Heterologous Transplantation><High Prevalence><Host Factor><Host Factor Protein><Human><Immunodeficient Mouse><Inbred Strain><Inbreeding><Increase lifespan><Individual><Integration Host Factors><Intermediary Metabolism><Intervention><Kinase Family Gene><Knowledge><Length of Life><Link><Longevity><Maintenance><Malignant Breast Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mammary Cancer><Mammary Carcinoma><Mammary Neoplasms><Maps><Mediating><Mediator><Metabolic><Metabolic Processes><Metabolism><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Metastatic breast cancer><Methionine><Methionine Metabolism><Methionine Metabolism Pathway><Mice><Mice Mammals><Modeling><Modern Man><Modification Methylases><Molecular><Morbidity><Mouse Strains><Murine><Mus><Neoplasm Metastasis><Normal Tissue><Normal tissue morphology><Nutrition Interventions><Nutritional Interventions><Oncogenesis><PDX model><Pathway interactions><Patient derived xenograft><Persons><Phenotype><Plant-Based Diet><Play><Population><Prevention><Property><Protein Kinase><RNA Expression><Rat><Rats Mammals><Rattus><Regulation><Research><Resistance><Rodent><Rodentia><Rodents Mammals><Role><S-Adenosylhomocysteine><S-Adenosylmethionine><S-adenosyl methionine><S-adenosyl-methionine><SAMe><Secondary Neoplasm><Secondary Tumor><Site-Directed Mutagenesis><Site-Specific DNA-methyltransferase><Site-Specific Mutagenesis><Societies><Stem Cell like><Targeted DNA Modification><Targeted Modification><Techniques><Testing><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Tumor Tissue><Vegan Diet><Work><Xenograft><Xenograft procedure><Xenotransplantation><adulthood><age associated><age associated disease><age associated disorder><age associated effects><age associated impairment><age associated pathologies><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age dependent pathologies><age effect><age induced pathologies><age linked><age related><age related effects><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><aged><aged mice><aged mouse><ages><aging associated><aging associated pathologies><aging delay><aging dependent pathologies><aging effect><aging induced pathologies><aging pathologies><aging process><aging related><aging related pathologies><aminoacid><analyze gene expression><anti-cancer><anti-cancer research><anti-cancer therapy><anti-tumor effect><antitumor effect><attenuate aging><biologic><biosynthesis><boost longevity><breast tumor cell><cancer initiation><cancer metastasis><cancer progression><cancer research><cancer therapy><cancer-directed therapy><cell culture><cell cultures><decelerate aging><delay age related><developmental><diet intervention><diet rich in plants><dietary><dietary restriction><elderly mice><elongating the lifespan><enhance longevity><epigenetic profiling><epigenetically><epigenome><experiment><experimental research><experimental study><experiments><extend life span><extend lifespan><extend longevity><foster longevity><gene expression analysis><gene expression assay><genetic approach><genetic strategy><geroprotectant><geroprotection><geroprotective><geroprotector><glycogen synthase a kinase><healthspan><healthy aging><healthy human aging><healthy life span><histone H3 methyltransferase><histone methylase><histone methylation><histone methyltransferase><histone modification><hydroxyalkyl protein kinase><impact of age><improve lifespan><improve longevity><improved><in vivo><influence of age><insight><interest><intervention enhancing longevity><intervention to extend lifespan><intervention to improve lifespan><intervention to increase longevity><intervention to prolong lifespan><intervention to promote longevity><juvenile animal><life span><lifespan><lifespan extending intervention><lifespan extending therapies><lifespan extension><lifespan improving intervention><lifespan increasing intervention><lifespan increasing therapies><lifespan intervention><lifespan prolonging interventions><lifespan promoting intervention><longevity boosting intervention><longevity extending intervention><longevity intervention><longevity promoting intervention><longevity therapy><longevity treatment><malignancy><malignant breast tumor><mammary cancer model><mammary tumor><mammary tumor model><metabolic phenotype><metabotype><metastatic breast tumor><metastatic mammary cancer><metastatic mammary tumor><model organism><mortality><mouse model><multidisciplinary><murine model><mutant><neoplasm progression><neoplasm/cancer><neoplastic progression><novel><old mice><older women><pathway><patient derived xenograft model><pause aging><pharmacologic><phosphorylase b kinase kinase><plant diet><plant focused diet><plant rich diet><plant-centered diet><postpone age related><prevent><preventing><pro-aging><progenitor capacity><progenitor cell like><progenitor-like><progeronic><prolong lifespan><prolong longevity><promote aging><promote lifespan><promote longevity><resistant><response><restricted diet><retards aging><self-renew><self-renewal><sensor><slow aging><slow down aging><slow the rate of aging><social role><stem cell characteristics><stem-like><stemness><strategy to enhance longevity><strategy to promote longevity><support longevity><transcriptional profiling><tumor><tumor cell metastasis><tumor growth><tumor initiation><tumor progression><tumorigenesis><vegan><veganism><xeno-transplant><xeno-transplantation><young animal>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Dudley William Lamming

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$599,465

FY 2026

Project Title

The regulation of cancer and aging by methionine

Grant Number:

5R01AG084156-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Age-related diseases, including cancer, are the major causes of morbidity and mortality in Western society. While cancer in the genetically heterogeneous human population primarily occurs in the aged, cancer research to-date has primarily utilized young, inbred animals. As the effec...

Research Terms

<21+ years old><4T1><ATP-protein phosphotransferase><Address><Ademetionine><AdoMet><Adult><Adult Human><Affect><Age><Age related pathologies><Aging><Amino Acids><Anabolism><Animal Cancer Model><Animals><Biological><Breast Cancer><Breast Cancer Cell><Breast Cancer Model><Breast Carcinoma><Breast Neoplasms><Breast Tumors><Breast tumor model><Cancer Treatment><Cancers><Cell Body><Cell Culture Techniques><Cell model><Cells><Cellular model><Common Rat Strains><DNA Methylation><DNA Methyltransferase><DNA Modification><DNA Modification Methylases><DNA Modification Methyltransferases><DNA Modification Process><DNA-Methyltransferases><Dependence><Development><Dietary Component><Dietary Intervention><Dietary Proteins><Dnmt><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Frequencies><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><Genetic Transcription><Health><Health Benefit><Heterograft><Heterologous Transplantation><High Prevalence><Host Factor><Host Factor Protein><Human><Immunodeficient Mouse><Inbred Strain><Inbreeding><Increase lifespan><Individual><Integration Host Factors><Intermediary Metabolism><Intervention><Kinase Family Gene><Knowledge><Length of Life><Link><Longevity><Maintenance><Malignant Breast Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mammary Cancer><Mammary Carcinoma><Mammary Neoplasms><Maps><Mediating><Mediator><Metabolic><Metabolic Processes><Metabolism><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Metastatic breast cancer><Methionine><Methionine Metabolism><Methionine Metabolism Pathway><Mice><Mice Mammals><Modeling><Modern Man><Modification Methylases><Molecular><Morbidity><Mouse Strains><Murine><Mus><Neoplasm Metastasis><Normal Tissue><Normal tissue morphology><Nutrition Interventions><Nutritional Interventions><Oncogenesis><PDX model><Pathway interactions><Patient derived xenograft><Persons><Phenotype><Plant-Based Diet><Play><Population><Prevention><Property><Protein Kinase><RNA Expression><Rat><Rats Mammals><Rattus><Regulation><Research><Resistance><Rodent><Rodentia><Rodents Mammals><Role><S-Adenosylhomocysteine><S-Adenosylmethionine><S-adenosyl methionine><S-adenosyl-methionine><SAMe><Secondary Neoplasm><Secondary Tumor><Site-Directed Mutagenesis><Site-Specific DNA-methyltransferase><Site-Specific Mutagenesis><Societies><Stem Cell like><Targeted DNA Modification><Targeted Modification><Techniques><Testing><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Tumor Tissue><Vegan Diet><Work><Xenograft><Xenograft procedure><Xenotransplantation><adulthood><age associated><age associated disease><age associated disorder><age associated effects><age associated impairment><age associated pathologies><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age dependent pathologies><age effect><age induced pathologies><age linked><age related><age related effects><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><aged><aged mice><aged mouse><ages><aging associated><aging associated pathologies><aging delay><aging dependent pathologies><aging effect><aging induced pathologies><aging pathologies><aging process><aging related><aging related pathologies><aminoacid><analyze gene expression><anti-cancer><anti-cancer research><anti-cancer therapy><anti-tumor effect><antitumor effect><attenuate aging><biologic><biosynthesis><boost longevity><breast tumor cell><cancer initiation><cancer metastasis><cancer progression><cancer research><cancer therapy><cancer-directed therapy><cell culture><cell cultures><decelerate aging><delay age related><developmental><diet intervention><diet rich in plants><dietary><dietary restriction><elderly mice><elongating the lifespan><enhance longevity><epigenetic profiling><epigenetically><epigenome><experiment><experimental research><experimental study><experiments><extend life span><extend lifespan><extend longevity><foster longevity><gene expression analysis><gene expression assay><genetic approach><genetic strategy><geroprotectant><geroprotection><geroprotective><geroprotector><glycogen synthase a kinase><healthspan><healthy aging><healthy human aging><healthy life span><histone H3 methyltransferase><histone methylase><histone methylation><histone methyltransferase><histone modification><hydroxyalkyl protein kinase><impact of age><improve lifespan><improve longevity><improved><in vivo><influence of age><insight><interest><intervention enhancing longevity><intervention to extend lifespan><intervention to improve lifespan><intervention to increase longevity><intervention to prolong lifespan><intervention to promote longevity><juvenile animal><life span><lifespan><lifespan extending intervention><lifespan extending therapies><lifespan extension><lifespan improving intervention><lifespan increasing intervention><lifespan increasing therapies><lifespan intervention><lifespan prolonging interventions><lifespan promoting intervention><longevity boosting intervention><longevity extending intervention><longevity intervention><longevity promoting intervention><longevity therapy><longevity treatment><malignancy><malignant breast tumor><mammary cancer model><mammary tumor><mammary tumor model><metabolic phenotype><metabotype><metastatic breast tumor><metastatic mammary cancer><metastatic mammary tumor><model organism><mortality><mouse model><multidisciplinary><murine model><mutant><neoplasm progression><neoplasm/cancer><neoplastic progression><novel><old mice><older women><pathway><patient derived xenograft model><pause aging><pharmacologic><phosphorylase b kinase kinase><plant diet><plant focused diet><plant rich diet><plant-centered diet><postpone age related><prevent><preventing><pro-aging><progenitor capacity><progenitor cell like><progenitor-like><progeronic><prolong lifespan><prolong longevity><promote aging><promote lifespan><promote longevity><resistant><response><restricted diet><retards aging><self-renew><self-renewal><sensor><slow aging><slow down aging><slow the rate of aging><social role><stem cell characteristics><stem-like><stemness><strategy to enhance longevity><strategy to promote longevity><support longevity><transcriptional profiling><tumor><tumor cell metastasis><tumor growth><tumor initiation><tumor progression><tumorigenesis><vegan><veganism><xeno-transplant><xeno-transplantation><young animal>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

DANICA CHEN

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$589,967

FY 2026

Project Title

Neural Stem Cell Aging and Neurodegeneration

Grant Number:

5R01AG082105-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Perturbation of mitochondrial proteostasis, a form of mitochondrial stress, activates the mitochondrial unfolded protein response (UPRmt), a retrograde signaling pathway leading to transcriptional up-regulation of mitochondrial chaperones and stress relief. Recent advances in mitocho...

Research Terms

View Full Project Details on NIH Reporter

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Nuo Sun

OHIO STATE UNIVERSITY, Columbus, OH

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$587,483

FY 2026

Project Title

Neddylation and mitophagy in cardiac aging

Grant Number:

5R01HL162909-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY A decline in mitochondrial quality and activity has been associated with normal aging and correlated with the development of a wide range of age-related diseases. Therefore, rejuvenating mitochondrial function or improving mitochondrial quality control might be an effective strategy...

Research Terms

<21+ years old><APF-1><ATP-Dependent Proteolysis Factor 1><Adult><Adult Human><Adverse effects><Age><Aging><Algorithm Design><Algorithmic Design><Algorithmic Engineering><Algorithms><Assay><Autoregulation><BCL2-Interacting Protein><Binding Proteins><Bioassay><Biological Assay><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Cell Culture Techniques><Collection><Complex><Cullin 2><Cullin 2 Protein><DNA Therapy><DP5><Data><Development><Drug Therapy><E3 Ligase><E3 Ubiquitin Ligase><Elderly><Enzyme Gene><Enzymes><Gene Transfer Clinical><Genetic><Genetic Intervention><Goals><HIF 1><HIF-1 protein><HIF1><HIF1 protein><HMG-20><HRK gene><Harakiri><Heart><Heart Muscle Cells><Heart Muscle tissue><Heart Vascular><Heart failure><Heart myocyte><High Mobility Protein 20><Homeostasis><Human><Image><Increase lifespan><Ligand Binding Protein><Ligand Binding Protein Gene><Link><Mediating><Mice><Mice Mammals><Mitochondria><Modern Man><Molecular><Murine><Mus><Myocardial depression><Myocardial dysfunction><Myocardial tissue><Pathologic><Pathology><Pathway interactions><Patients><Pharmacological Treatment><Pharmacotherapy><Physiologic><Physiological><Physiological Homeostasis><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Protein Binding><Protein Modification><Proteins><Quality Control><RBX1><RBX1 gene><RING-Box 1><ROC1><Reagent><Receptor Protein><Regulation><Regulator of Cullins 1><Reporter><Research><Role><Scaffolding Protein><Therapeutic><Tissue Sample><Ubiquitilation><Ubiquitin><Ubiquitin Like Proteins><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><VHL gene product><VHL protein><abrogation of mitochondrial dysfunction><adult youth><adulthood><advanced age><age associated><age associated cardiac dysfunction><age associated decline><age associated disease><age associated disorder><age associated effects><age associated heart dysfunction><age associated impairment><age correlated><age dependent><age dependent decline><age dependent disease><age dependent disorder><age dependent impairment><age effect><age induced cardiac dysfunction><age linked><age related><age related cardiac dysfunction><age related decline><age related effects><age related heart dysfunction><age related human disease><age reversal><age specific><age-related disease><age-related disorder><age-related impairment><aged><aged mice><aged mouse><ages><aging associated><aging effect><aging related><aging reversal><algorithm engineering><algorithmic composition><alleviate age related><alleviate aging><alleviating mitochondrial dysfunction><ameliorating aging><ameliorating mitochondrial dysfunction><attenuation of mitochondrial dysfunction><boost longevity><bound protein><cardiac aging><cardiac dysfunction><cardiac failure><cardiac function><cardiac myocytes differentiated from induced pluripotent stem cell><cardiomyocyte><cardioprotectant><cardioprotection><cardioprotective><cardiovascular function><cardiovascular health><cell culture><cell cultures><circulatory system><combat><counter age related><counter aging><counteract age related><counteract aging><decline with age><developmental><disease risk><disorder risk><drug intervention><drug treatment><elderly mice><elongating the lifespan><elongin B><enhance longevity><extend life span><extend lifespan><extend longevity><foster longevity><function of the heart><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><geriatric><heart aging><heart dysfunction><heart function><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><hypoxia inducible factor 1><iPS cell derived cardiomyocytes><iPSC derived cardiomyocytes><imaging><impact of age><improve lifespan><improve longevity><improved><in vivo monitoring><induced human pluripotent stem cells><induced pluripotent stem cell derived cardiac myocytes><induced pluripotent stem cell derived cardiomyocytes><inducible pluripotent stem cell derived cardiac myocytes><inducible pluripotent stem cells derived cardiomyocytes><influence of age><inhibitor><innovate><innovation><innovative><insight><lifespan extension><mitigating mitochondrial impairment><mitochondrial><mitochondrial rejuvenation><model organism><mortality><mouse model><murine model><natural aging><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><normal aging><normative aging><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><old mice><pathway><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><preservation><prevent><preventing><prolong lifespan><prolong longevity><promote lifespan><promote longevity><receptor><reducing mitochondrial dysfunction><reverse age><reverse aging><reverse aging effects><reversible aging><senior citizen><social role><spatial and temporal><spatial temporal><spatiotemporal><support longevity><suppress mitochondrial dysfunction><therapeutic target><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase><von Hippel Lindau disease gene product><von Hippel Lindau disease protein><von Hippel Lindau gene product><von Hippel Lindau protein><young adult><young adult age><young adulthood>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jessica Faul

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$586,208

FY 2026

Project Title

Biological Aging Across the Life Course: Harmonizing Cohort Biospecimen Archives

Grant Number:

5R01AG071071-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2021

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

As the US rapidly transitions into an aging society, aging-associated diseases are increasing in both prevalence and cost. Compounding this concern is evidence that cohorts entering adulthood and midlife today are less healthy than preceding generations were at those ages. The faster rate of aging a...

Research Terms

<15 year old><15 years of age><21+ years old><9 year old><9 years of age><Add Health><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Age><Aging><Amino-terminal pro-brain natriuretic peptide><Application Context><Area><Assay><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BMI><BMI percentile><BMI z-score><BSF-2><BSF2><Bioassay><Biochemistry><Biological Aging><Biological Assay><Biological Chemistry><Biological Markers><Birth><Blood Chemical Analyses><Blood Chemical Analysis><Blood Pressure><Body mass index><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Child Welfare><Childhood><Cities><Cognition><Communities><DNA Methylation><Data><Data Set><Detection><Disease Progression><Early Diagnosis><Environment><Ethnic Origin><Ethnicity><Exposure to><Family><GDF15><GDF15 gene><Gene Expression><Generations><Glycohemoglobin A><Glycosylated hemoglobin A><HPGF><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Health Care><Health and Retirement Study><Hemoglobin A(1)><Hepatocyte-Stimulating Factor><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IGF-1><IGF-I><IGF-I-SmC><IL-6><IL6 Protein><Immune><Immunes><Impoverished><Individual><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Interleukin-6><Intervention><Intracellular Communication and Signaling><Investigators><Length of Life><Life><Life Cycle><Life Cycle Stages><Link><Longevity><Longitudinal Studies><Longitudinal Surveys><MGI-2><MIC-1 gene product><MIC1><Macrophage Inhibitory Cytokine-1><Measures><Mediating><Mental Health><Mental Hygiene><Methods><Methylation><Myeloid Differentiation-Inducing Protein><N-BNP peptide><N-terminal pro-BNP><NAG-1 protein><NAG1><NSAID activated gene-1 product><NSAID-Activated Protein 1><NSAID-Regulated Protein 1><NT-BNP><NT-proBNP><National Longitudinal Study of Adolescent Health><National Longitudinal Survey of Adolescent to Adult Health><Non-Polyadenylated RNA><Nonsteroidal Anti-Inflammatory Drug-Activated Protein 1><Outcome><PLAB><PLAB Protein><PTGF-Beta><Parturition><Patient Self-Report><Phenotype><Physiologic><Physiological><Placental Bone Morphogenic Protein><Placental TGF-Beta><Plasmacytoma Growth Factor><Population><Poverty><Prevalence><Prevention><Production><Prostate Differentiation Factor><Psychological Health><Quality Control><Quetelet index><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Race><Races><Research><Research Personnel><Researchers><Ribonucleic Acid><Sampling><Self-Report><Signal Transduction><Signal Transduction Systems><Signaling><Social Environment><Societies><Socio-economic status><Socioeconomic Status><Somatomedin C><Subgroup><Survey Instrument><Surveys><Symptoms><Testing><Trauma><adolescent welfare><adulthood><age 15><age 15 years><age 9><age 9 years><age associated biomarkers><age associated disease><age associated disorder><age associated impairment><age associated marker><age dependent disease><age dependent disorder><age dependent impairment><age marker><age related biomarkers><age related human disease><age related markers><age-related disease><age-related disorder><age-related impairment><ages><aging associated disease><aging associated disorders><aging biological marker><aging biomarker><aging delay><aging marker><aging process><aging related disease><aging related disorders><attenuate aging><bio-markers><biobank><biologic marker><biological markers of age><biological process of age><biological signal transduction><biological specimen archives><biomarker><biomarker validation><biomarkers of age><biorepository><biosample archive><biospecimen archive><blood chemistry><blood-based biomarker><blood-based marker><child well being><child wellbeing><clinical practice><cohort><contextual factors><cost><cystatin C><data harmonization><decelerate aging><delay age related><demographics><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><early detection><family structure><fifteen year old><fifteen years of age><growth differentiation factor 15><harmonized data><healthspan><healthy life span><hemoglobin A1c><insight><interferon beta 2><juvenile><juvenile human><later in life><later life><life course><long-term study><longitudinal outcome studies><longitudinal research study><marker validation><mid life><mid-life><middle age><middle aged><midlife><nine year old><nine years of age><pace of aging><pace of biological aging><pause aging><pediatric><post gamma-globulins><post-gamma-protein><postpone age related><pro-brain natriuretic peptide (1-76)><proBNP(1-76)><racial><racial background><racial origin><rate of aging><rate of biological aging><retards aging><secondary analysis><sex><slow aging><slow down aging><slow the rate of aging><social adversity><social climate><social context><socio-demographics><socio-economic position><sociodemographics><socioeconomic position><socioenvironment><socioenvironmental><specimen archive><speed of aging><speed of the aging><transcriptome sequencing><transcriptomic sequencing><traumatic event>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Lauren M Gaydosh

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$586,208

FY 2026

Project Title

Biological Aging Across the Life Course: Harmonizing Cohort Biospecimen Archives

Grant Number:

5R01AG071071-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2021

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

As the US rapidly transitions into an aging society, aging-associated diseases are increasing in both prevalence and cost. Compounding this concern is evidence that cohorts entering adulthood and midlife today are less healthy than preceding generations were at those ages. The faster rate of aging a...

Research Terms

<15 year old><15 years of age><21+ years old><9 year old><9 years of age><Add Health><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Age><Aging><Amino-terminal pro-brain natriuretic peptide><Application Context><Area><Assay><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BMI><BMI percentile><BMI z-score><BSF-2><BSF2><Bioassay><Biochemistry><Biological Aging><Biological Assay><Biological Chemistry><Biological Markers><Birth><Blood Chemical Analyses><Blood Chemical Analysis><Blood Pressure><Body mass index><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Child Welfare><Childhood><Cities><Cognition><Communities><DNA Methylation><Data><Data Set><Detection><Disease Progression><Early Diagnosis><Environment><Ethnic Origin><Ethnicity><Exposure to><Family><GDF15><GDF15 gene><Gene Expression><Generations><Glycohemoglobin A><Glycosylated hemoglobin A><HPGF><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Health Care><Health and Retirement Study><Hemoglobin A(1)><Hepatocyte-Stimulating Factor><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IGF-1><IGF-I><IGF-I-SmC><IL-6><IL6 Protein><Immune><Immunes><Impoverished><Individual><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Interleukin-6><Intervention><Intracellular Communication and Signaling><Investigators><Length of Life><Life><Life Cycle><Life Cycle Stages><Link><Longevity><Longitudinal Studies><Longitudinal Surveys><MGI-2><MIC-1 gene product><MIC1><Macrophage Inhibitory Cytokine-1><Measures><Mediating><Mental Health><Mental Hygiene><Methods><Methylation><Myeloid Differentiation-Inducing Protein><N-BNP peptide><N-terminal pro-BNP><NAG-1 protein><NAG1><NSAID activated gene-1 product><NSAID-Activated Protein 1><NSAID-Regulated Protein 1><NT-BNP><NT-proBNP><National Longitudinal Study of Adolescent Health><National Longitudinal Survey of Adolescent to Adult Health><Non-Polyadenylated RNA><Nonsteroidal Anti-Inflammatory Drug-Activated Protein 1><Outcome><PLAB><PLAB Protein><PTGF-Beta><Parturition><Patient Self-Report><Phenotype><Physiologic><Physiological><Placental Bone Morphogenic Protein><Placental TGF-Beta><Plasmacytoma Growth Factor><Population><Poverty><Prevalence><Prevention><Production><Prostate Differentiation Factor><Psychological Health><Quality Control><Quetelet index><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Race><Races><Research><Research Personnel><Researchers><Ribonucleic Acid><Sampling><Self-Report><Signal Transduction><Signal Transduction Systems><Signaling><Social Environment><Societies><Socio-economic status><Socioeconomic Status><Somatomedin C><Subgroup><Survey Instrument><Surveys><Symptoms><Testing><Trauma><adolescent welfare><adulthood><age 15><age 15 years><age 9><age 9 years><age associated biomarkers><age associated disease><age associated disorder><age associated impairment><age associated marker><age dependent disease><age dependent disorder><age dependent impairment><age marker><age related biomarkers><age related human disease><age related markers><age-related disease><age-related disorder><age-related impairment><ages><aging associated disease><aging associated disorders><aging biological marker><aging biomarker><aging delay><aging marker><aging process><aging related disease><aging related disorders><attenuate aging><bio-markers><biobank><biologic marker><biological markers of age><biological process of age><biological signal transduction><biological specimen archives><biomarker><biomarker validation><biomarkers of age><biorepository><biosample archive><biospecimen archive><blood chemistry><blood-based biomarker><blood-based marker><child well being><child wellbeing><clinical practice><cohort><contextual factors><cost><cystatin C><data harmonization><decelerate aging><delay age related><demographics><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><early detection><family structure><fifteen year old><fifteen years of age><growth differentiation factor 15><harmonized data><healthspan><healthy life span><hemoglobin A1c><insight><interferon beta 2><juvenile><juvenile human><later in life><later life><life course><long-term study><longitudinal outcome studies><longitudinal research study><marker validation><mid life><mid-life><middle age><middle aged><midlife><nine year old><nine years of age><pace of aging><pace of biological aging><pause aging><pediatric><post gamma-globulins><post-gamma-protein><postpone age related><pro-brain natriuretic peptide (1-76)><proBNP(1-76)><racial><racial background><racial origin><rate of aging><rate of biological aging><retards aging><secondary analysis><sex><slow aging><slow down aging><slow the rate of aging><social adversity><social climate><social context><socio-demographics><socio-economic position><sociodemographics><socioeconomic position><socioenvironment><socioenvironmental><specimen archive><speed of aging><speed of the aging><transcriptome sequencing><transcriptomic sequencing><traumatic event>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

COLTER M.S. MITCHELL

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$586,208

FY 2026

Project Title

Biological Aging Across the Life Course: Harmonizing Cohort Biospecimen Archives

Grant Number:

5R01AG071071-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2021

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

As the US rapidly transitions into an aging society, aging-associated diseases are increasing in both prevalence and cost. Compounding this concern is evidence that cohorts entering adulthood and midlife today are less healthy than preceding generations were at those ages. The faster rate of aging a...

Research Terms

<15 year old><15 years of age><21+ years old><9 year old><9 years of age><Add Health><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Age><Aging><Amino-terminal pro-brain natriuretic peptide><Application Context><Area><Assay><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BMI><BMI percentile><BMI z-score><BSF-2><BSF2><Bioassay><Biochemistry><Biological Aging><Biological Assay><Biological Chemistry><Biological Markers><Birth><Blood Chemical Analyses><Blood Chemical Analysis><Blood Pressure><Body mass index><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Child Welfare><Childhood><Cities><Cognition><Communities><DNA Methylation><Data><Data Set><Detection><Disease Progression><Early Diagnosis><Environment><Ethnic Origin><Ethnicity><Exposure to><Family><GDF15><GDF15 gene><Gene Expression><Generations><Glycohemoglobin A><Glycosylated hemoglobin A><HPGF><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Health Care><Health and Retirement Study><Hemoglobin A(1)><Hepatocyte-Stimulating Factor><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IGF-1><IGF-I><IGF-I-SmC><IL-6><IL6 Protein><Immune><Immunes><Impoverished><Individual><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Interleukin-6><Intervention><Intracellular Communication and Signaling><Investigators><Length of Life><Life><Life Cycle><Life Cycle Stages><Link><Longevity><Longitudinal Studies><Longitudinal Surveys><MGI-2><MIC-1 gene product><MIC1><Macrophage Inhibitory Cytokine-1><Measures><Mediating><Mental Health><Mental Hygiene><Methods><Methylation><Myeloid Differentiation-Inducing Protein><N-BNP peptide><N-terminal pro-BNP><NAG-1 protein><NAG1><NSAID activated gene-1 product><NSAID-Activated Protein 1><NSAID-Regulated Protein 1><NT-BNP><NT-proBNP><National Longitudinal Study of Adolescent Health><National Longitudinal Survey of Adolescent to Adult Health><Non-Polyadenylated RNA><Nonsteroidal Anti-Inflammatory Drug-Activated Protein 1><Outcome><PLAB><PLAB Protein><PTGF-Beta><Parturition><Patient Self-Report><Phenotype><Physiologic><Physiological><Placental Bone Morphogenic Protein><Placental TGF-Beta><Plasmacytoma Growth Factor><Population><Poverty><Prevalence><Prevention><Production><Prostate Differentiation Factor><Psychological Health><Quality Control><Quetelet index><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Race><Races><Research><Research Personnel><Researchers><Ribonucleic Acid><Sampling><Self-Report><Signal Transduction><Signal Transduction Systems><Signaling><Social Environment><Societies><Socio-economic status><Socioeconomic Status><Somatomedin C><Subgroup><Survey Instrument><Surveys><Symptoms><Testing><Trauma><adolescent welfare><adulthood><age 15><age 15 years><age 9><age 9 years><age associated biomarkers><age associated disease><age associated disorder><age associated impairment><age associated marker><age dependent disease><age dependent disorder><age dependent impairment><age marker><age related biomarkers><age related human disease><age related markers><age-related disease><age-related disorder><age-related impairment><ages><aging associated disease><aging associated disorders><aging biological marker><aging biomarker><aging delay><aging marker><aging process><aging related disease><aging related disorders><attenuate aging><bio-markers><biobank><biologic marker><biological markers of age><biological process of age><biological signal transduction><biological specimen archives><biomarker><biomarker validation><biomarkers of age><biorepository><biosample archive><biospecimen archive><blood chemistry><blood-based biomarker><blood-based marker><child well being><child wellbeing><clinical practice><cohort><contextual factors><cost><cystatin C><data harmonization><decelerate aging><delay age related><demographics><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><early detection><family structure><fifteen year old><fifteen years of age><growth differentiation factor 15><harmonized data><healthspan><healthy life span><hemoglobin A1c><insight><interferon beta 2><juvenile><juvenile human><later in life><later life><life course><long-term study><longitudinal outcome studies><longitudinal research study><marker validation><mid life><mid-life><middle age><middle aged><midlife><nine year old><nine years of age><pace of aging><pace of biological aging><pause aging><pediatric><post gamma-globulins><post-gamma-protein><postpone age related><pro-brain natriuretic peptide (1-76)><proBNP(1-76)><racial><racial background><racial origin><rate of aging><rate of biological aging><retards aging><secondary analysis><sex><slow aging><slow down aging><slow the rate of aging><social adversity><social climate><social context><socio-demographics><socio-economic position><sociodemographics><socioeconomic position><socioenvironment><socioenvironmental><specimen archive><speed of aging><speed of the aging><transcriptome sequencing><transcriptomic sequencing><traumatic event>

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Osvaldo Delbono

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$581,796

FY 2026

Project Title

Role of Central Autonomic Relays in Aging Sarcopenia

Grant Number:

5R01AG071545-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Summary: SNS failure is common in old age and neurodegenerative diseases that impair adaptation to common physiological stressors. We and others found that sympathetic axons innervate skeletal muscle fibers and maintain the integrity of skeletal muscle composition and function at the presynaptic and...

Research Terms

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LaTonya J Hickson

MAYO CLINIC JACKSONVILLE, JACKSONVILLE, FL

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$578,941

FY 2026

Project Title

Extracellular vesicle-based senotherapeutics for aging diabetic kidneydisease

Grant Number:

5R01AG076537-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The rise in an aging population plagued by obesity and diabetes mellitus is projected to render exponential growth in diabetic kidney disease (DKD). Hence, therapeutic interventions that halt aging-related kidney changes and DKD must be rigorously pursued. Maladaptive inflammation dr...

Research Terms

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Alan Blair McMillan

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$575,753

FY 2026

Project Title

PET/MR Correlates of Accelerated Aging in Chronic Epilepsy

Grant Number:

5R01NS117568-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2021

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Epilepsy affects more than 2 million Americans and is the fourth most common neurological disorder. While many patients experience long-term remission, lifelong chronic epilepsy is associated with cognitive, psychiatric, and somatic comorbidities and a well-characterized neuroimaging burden. Recentl...

Research Terms

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Vivek Prabhakaran

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$575,753

FY 2026

Project Title

PET/MR Correlates of Accelerated Aging in Chronic Epilepsy

Grant Number:

5R01NS117568-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2021

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Epilepsy affects more than 2 million Americans and is the fourth most common neurological disorder. While many patients experience long-term remission, lifelong chronic epilepsy is associated with cognitive, psychiatric, and somatic comorbidities and a well-characterized neuroimaging burden. Recentl...

Research Terms

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James Edward Bruce

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$545,068

FY 2026

Project Title

Aging Mitochondrial Interactome

Grant Number:

5R01AG078279-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Mitochondria play a central role in age-related pathologies, loss of resilience, and the decline in quality of life in older adults. As we age changes in mitochondrial function lead to disruption of redox and energy homeostasis, altered metabolite levels, impaired calcium regulation, and increased s...

Research Terms

<2-ketoglutarate><2-oxoglutarate><21+ years old><ATP Synthesis><ATP Synthesis Pathway><Activity Cycles><Acute><Address><Adult><Adult Human><Age><Age related pathologies><Aging><Assay><Autoregulation><Bioassay><Biological Assay><Biopsy><Body Tissues><Calcium><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Chemicals><Citric Acid Cycle><Complex><Data><Decline in mobility><Decrease in mobility><Decreased mobility><Diminished mobility><Dysfunction><Electron Transport><Functional disorder><Genes><Glutamate Dehydrogenase><Glutamate Metabolism><Glutamate Metabolism Pathway><Glutamates><Heart><Heart Vascular><Homeostasis><Human><IPO-B><Impairment><In Vitro><Indophenol Oxidase B><Intermediary Metabolism><Intervention><Krebs Cycle><L-Glutamate><Lead><Link><MNSOD><Manganese Superoxide Dismutase><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Mediating><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondria><Mitochondrial Proteins><Mitochondrial Superoxide Dismutase><Mn Superoxide Dismutase><Mn-SOD><Mobility decline><Mobility impairment><Modeling><Modern Man><Molecular><Murine><Mus><Muscle><Muscle Mitochondria><Muscle Tissue><Myocardium><Nature><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Organ><Organelles><Oxidation-Reduction><Pb element><Peptides><Permeability><Phosphorylation><Physiological Homeostasis><Physiopathology><Play><Position><Positioning Attribute><Production><Protein Conformation><Protein Phosphorylation><Proteins><QOL><Quality of life><Redox><Reduced mobility><Reduction in mobility><Regulation><Regulatory Regions><Research><Respiration><Role><SOD2><SOD2 gene><Sarcosomes><Site><Skeletal Muscle><Stress><Superoxide Dismutase 2><System><TCA cycle><Testing><Tissues><Translating><Tricarboxylic Acid Cycle><Uncertainty><Voluntary Muscle><adult youth><adulthood><age associated><age associated alterations><age associated changes><age associated pathologies><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent pathologies><age induced alterations><age induced changes><age induced pathologies><age linked><age related><age related alterations><age related changes><age reversal><age specific><age specific alterations><age specific changes><aged><aged mice><aged mouse><ages><aging associated alterations><aging associated changes><aging associated pathologies><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging dependent pathologies><aging induced alterations><aging induced changes><aging induced pathologies><aging pathologies><aging related alterations><aging related changes><aging related pathologies><aging reversal><aging specific alterations><aging specific changes><alleviate age related><alleviate aging><alpha ketoglutarate><alterations with age><ameliorating aging><cardiac muscle><cardiac myocytes differentiated from induced pluripotent stem cell><catalase><changes with age><circulatory system><counter age related><counter aging><counteract age related><counteract aging><crosslink><decline in function><decline in functional status><doubt><elderly mice><electron transfer><experiment><experimental research><experimental study><experiments><functional decline><functional status decline><genetic regulatory element><glutamatergic><glutamic dehydrogenase><heart muscle><heavy metal Pb><heavy metal lead><human subject><iPS cell derived cardiomyocytes><iPSC derived cardiomyocytes><improved><in vivo><induced pluripotent stem cell derived cardiac myocytes><induced pluripotent stem cell derived cardiomyocytes><inducible pluripotent stem cell derived cardiac myocytes><inducible pluripotent stem cells derived cardiomyocytes><innovate><innovation><innovative><insight><knock-down><knockdown><mitochondrial><mitochondrial dysfunction><mitochondrial metabolism><mouse model><murine model><muscular><neuromuscular><novel><old mice><older adult><older adulthood><oxidation reduction reaction><pathophysiology><protein complex><resilience><resilient><respiratory mechanism><reverse age><reverse aging><reverse aging effects><reversible aging><social role><tool><young adult><young adult age><young adulthood><α-ketoglutarate><α-oxoglutarate><αKG>

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David J. Marcinek

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$545,068

FY 2026

Project Title

Aging Mitochondrial Interactome

Grant Number:

5R01AG078279-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Mitochondria play a central role in age-related pathologies, loss of resilience, and the decline in quality of life in older adults. As we age changes in mitochondrial function lead to disruption of redox and energy homeostasis, altered metabolite levels, impaired calcium regulation, and increased s...

Research Terms

<2-ketoglutarate><2-oxoglutarate><21+ years old><ATP Synthesis><ATP Synthesis Pathway><Activity Cycles><Acute><Address><Adult><Adult Human><Age><Age related pathologies><Aging><Assay><Autoregulation><Bioassay><Biological Assay><Biopsy><Body Tissues><Calcium><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Chemicals><Citric Acid Cycle><Complex><Data><Decline in mobility><Decrease in mobility><Decreased mobility><Diminished mobility><Dysfunction><Electron Transport><Functional disorder><Genes><Glutamate Dehydrogenase><Glutamate Metabolism><Glutamate Metabolism Pathway><Glutamates><Heart><Heart Vascular><Homeostasis><Human><IPO-B><Impairment><In Vitro><Indophenol Oxidase B><Intermediary Metabolism><Intervention><Krebs Cycle><L-Glutamate><Lead><Link><MNSOD><Manganese Superoxide Dismutase><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Mediating><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondria><Mitochondrial Proteins><Mitochondrial Superoxide Dismutase><Mn Superoxide Dismutase><Mn-SOD><Mobility decline><Mobility impairment><Modeling><Modern Man><Molecular><Murine><Mus><Muscle><Muscle Mitochondria><Muscle Tissue><Myocardium><Nature><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Organ><Organelles><Oxidation-Reduction><Pb element><Peptides><Permeability><Phosphorylation><Physiological Homeostasis><Physiopathology><Play><Position><Positioning Attribute><Production><Protein Conformation><Protein Phosphorylation><Proteins><QOL><Quality of life><Redox><Reduced mobility><Reduction in mobility><Regulation><Regulatory Regions><Research><Respiration><Role><SOD2><SOD2 gene><Sarcosomes><Site><Skeletal Muscle><Stress><Superoxide Dismutase 2><System><TCA cycle><Testing><Tissues><Translating><Tricarboxylic Acid Cycle><Uncertainty><Voluntary Muscle><adult youth><adulthood><age associated><age associated alterations><age associated changes><age associated pathologies><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent pathologies><age induced alterations><age induced changes><age induced pathologies><age linked><age related><age related alterations><age related changes><age reversal><age specific><age specific alterations><age specific changes><aged><aged mice><aged mouse><ages><aging associated alterations><aging associated changes><aging associated pathologies><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging dependent pathologies><aging induced alterations><aging induced changes><aging induced pathologies><aging pathologies><aging related alterations><aging related changes><aging related pathologies><aging reversal><aging specific alterations><aging specific changes><alleviate age related><alleviate aging><alpha ketoglutarate><alterations with age><ameliorating aging><cardiac muscle><cardiac myocytes differentiated from induced pluripotent stem cell><catalase><changes with age><circulatory system><counter age related><counter aging><counteract age related><counteract aging><crosslink><decline in function><decline in functional status><doubt><elderly mice><electron transfer><experiment><experimental research><experimental study><experiments><functional decline><functional status decline><genetic regulatory element><glutamatergic><glutamic dehydrogenase><heart muscle><heavy metal Pb><heavy metal lead><human subject><iPS cell derived cardiomyocytes><iPSC derived cardiomyocytes><improved><in vivo><induced pluripotent stem cell derived cardiac myocytes><induced pluripotent stem cell derived cardiomyocytes><inducible pluripotent stem cell derived cardiac myocytes><inducible pluripotent stem cells derived cardiomyocytes><innovate><innovation><innovative><insight><knock-down><knockdown><mitochondrial><mitochondrial dysfunction><mitochondrial metabolism><mouse model><murine model><muscular><neuromuscular><novel><old mice><older adult><older adulthood><oxidation reduction reaction><pathophysiology><protein complex><resilience><resilient><respiratory mechanism><reverse age><reverse aging><reverse aging effects><reversible aging><social role><tool><young adult><young adult age><young adulthood><α-ketoglutarate><α-oxoglutarate><αKG>

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Laura M Calvi

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$534,854

FY 2026

Project Title

Mechanisms of marrow microenvironmental aging and their impact of progression of clonal hematopoiesis

Grant Number:

5R01AG079556-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Abstract Mutated clones in hematopoietic cells, also known as clonal hematopoiesis (CH) are present in healthy individuals and expand with aging. In spite of normal hematopoietic parameters, individuals with CH have increased risk of myeloid neoplasms, cardiovascular risk and all-cause morta...

Research Terms

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JANE L. LIESVELD

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$534,854

FY 2026

Project Title

Mechanisms of marrow microenvironmental aging and their impact of progression of clonal hematopoiesis

Grant Number:

5R01AG079556-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Abstract Mutated clones in hematopoietic cells, also known as clonal hematopoiesis (CH) are present in healthy individuals and expand with aging. In spite of normal hematopoietic parameters, individuals with CH have increased risk of myeloid neoplasms, cardiovascular risk and all-cause morta...

Research Terms

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Ana Julia Chucair-Elliott

OKLAHOMA MEDICAL RESEARCH FOUNDATION, OKLAHOMA CITY, OK

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$531,146

FY 2026

Project Title

Retinal Pigmented Epithelium Epigenome Dysregulation With Aging and Modulation by Diet

Grant Number:

5R01EY034946-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract/Summary Aging is the principal risk factor for age-related macular degeneration (AMD), a neurodegenerative disease characterized by the irreversible loss of vision. Clinical and mouse studies indicate that consumption of diets with higher dietary glycemic indices increase AMD risk. Atrophy ...

Research Terms

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WILLARD M FREEMAN

OKLAHOMA MEDICAL RESEARCH FOUNDATION, OKLAHOMA CITY, OK

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$531,146

FY 2026

Project Title

Retinal Pigmented Epithelium Epigenome Dysregulation With Aging and Modulation by Diet

Grant Number:

5R01EY034946-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Abstract/Summary Aging is the principal risk factor for age-related macular degeneration (AMD), a neurodegenerative disease characterized by the irreversible loss of vision. Clinical and mouse studies indicate that consumption of diets with higher dietary glycemic indices increase AMD risk. Atrophy ...

Research Terms

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JEFF M HASTY

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$523,991

FY 2026

Project Title

Network-Driven Dynamics of Replicative Aging

Grant Number:

5R01AG056440-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary This project aims at integrating computational modeling and innovative measurement technologies to understand the complexity of single-cell aging and the emergent dynamics from the underlying regulatory networks. Aging is closely associated with many diseases, such cancer, diabetes,...

Research Terms

<(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase><20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><5'-AMP-activated protein kinase><AMP-activated kinase><AMP-activated protein kinase><AMPK enzyme><Affect><Aging><Automobile Driving><Autophagocytosis><Autoregulation><Baker's Yeast><Biology of Aging><Brewer's Yeast><Cancers><Cell Aging><Cell Body><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Chaperone><Complex><Computer Models><Computerized Models><Consumption><Data><Deacetylase><Degenerative Neurologic Disorders><Development><Diabetes Mellitus><Disease><Disorder><Environment><Environmental Factor><Environmental Risk Factor><Equilibrium><Eukaryota><Eukaryote><Ferroprotoporphyrin><Foundations><Funding><Gene Transcription><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><HMG CoA reductase (NADPH) kinase><HMG CoA reductase kinase><HMG coenzyme A reductase (NADPH) kinase><Heat Shock><Heat-Shock Reaction><Heat-Shock Response><Heme><Homeostasis><Human><Imaging technology><Incidence><Increase lifespan><Individual><Intermediary Metabolism><Intervention Strategies><L-Lysine><Length of Life><Longevity><Lysine><Macropain><Macroxyproteinase><Malignant Neoplasms><Malignant Tumor><Measurement><Mediating><Metabolic><Metabolic Processes><Metabolism><Microfluidics><Mitochondria><Modeling><Modern Man><Molecular><Molecular Chaperones><Multicatalytic Proteinase><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Nutrient><Pathway interactions><Phenotype><Physiological Homeostasis><Process><Production><Property><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteosome><Protoheme><RNA Expression><Recombinant DNA Technology><Regulation><Replicative Senescence><Research><Ribosomal DNA><Role><S cerevisiae><S. cerevisiae><Saccharomyces cerevisiae><Stochastic Processes><Stress><System><Systems Biology><Technology><Testing><Therapeutic Intervention><Transcription><Yeasts><abnormal protein homeostasis><abnormal proteostasis><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><aging associated><aging process><aging related><autophagy><balance><balance function><boost longevity><cell age><cellular age><computational modeling><computational models><computer based models><computerized modeling><decline in function><decline in functional status><defective proteostasis><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diabetes><driving><dynamic system><dynamical system><elongating the lifespan><enhance longevity><environmental change><environmental risk><experiment><experimental research><experimental study><experiments><extend life span><extend lifespan><extend longevity><ferroheme><foster longevity><functional decline><functional status decline><gene interaction><gene network><genetically engineered><hallmarks of aging><healthspan><healthy life span><hydroxymethylglutaryl-CoA-reductase kinase><improve lifespan><improve longevity><innovate><innovation><innovative><insoluble aggregate><intervention therapy><life span><lifespan><lifespan extension><malignancy><mitochondrial><model organism><multicatalytic endopeptidase complex><multidisciplinary><neoplasm/cancer><neurodegenerative illness><pace of aging><pace of biological aging><pathway><pillars of aging><population based><prolong lifespan><prolong longevity><promote lifespan><promote longevity><protein aggregate><protein aggregation><protein folding><protein homeostasis><protein homeostasis decline><protein homeostasis deficiency><protein homeostasis dysfunction><protein homeostasis failure><protein homeostasis loss><proteostasis><proteostasis decline><proteostasis defect><proteostasis deficiency><proteostasis dysfunction><proteostasis dysregulation><proteostasis failure><proteostasis impairment><proteostasis loss><proteotoxic><proteotoxicity><rDNA><rate of aging><rate of biological aging><replicative aging><sensor><social role><speed of aging><speed of the aging><stochastic method><success><support longevity><µfluidic>

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Nan Hao

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$523,991

FY 2026

Project Title

Network-Driven Dynamics of Replicative Aging

Grant Number:

5R01AG056440-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary This project aims at integrating computational modeling and innovative measurement technologies to understand the complexity of single-cell aging and the emergent dynamics from the underlying regulatory networks. Aging is closely associated with many diseases, such cancer, diabetes,...

Research Terms

<(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase><20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><5'-AMP-activated protein kinase><AMP-activated kinase><AMP-activated protein kinase><AMPK enzyme><Affect><Aging><Automobile Driving><Autophagocytosis><Autoregulation><Baker's Yeast><Biology of Aging><Brewer's Yeast><Cancers><Cell Aging><Cell Body><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Chaperone><Complex><Computer Models><Computerized Models><Consumption><Data><Deacetylase><Degenerative Neurologic Disorders><Development><Diabetes Mellitus><Disease><Disorder><Environment><Environmental Factor><Environmental Risk Factor><Equilibrium><Eukaryota><Eukaryote><Ferroprotoporphyrin><Foundations><Funding><Gene Transcription><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><HMG CoA reductase (NADPH) kinase><HMG CoA reductase kinase><HMG coenzyme A reductase (NADPH) kinase><Heat Shock><Heat-Shock Reaction><Heat-Shock Response><Heme><Homeostasis><Human><Imaging technology><Incidence><Increase lifespan><Individual><Intermediary Metabolism><Intervention Strategies><L-Lysine><Length of Life><Longevity><Lysine><Macropain><Macroxyproteinase><Malignant Neoplasms><Malignant Tumor><Measurement><Mediating><Metabolic><Metabolic Processes><Metabolism><Microfluidics><Mitochondria><Modeling><Modern Man><Molecular><Molecular Chaperones><Multicatalytic Proteinase><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Nutrient><Pathway interactions><Phenotype><Physiological Homeostasis><Process><Production><Property><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteosome><Protoheme><RNA Expression><Recombinant DNA Technology><Regulation><Replicative Senescence><Research><Ribosomal DNA><Role><S cerevisiae><S. cerevisiae><Saccharomyces cerevisiae><Stochastic Processes><Stress><System><Systems Biology><Technology><Testing><Therapeutic Intervention><Transcription><Yeasts><abnormal protein homeostasis><abnormal proteostasis><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><aging associated><aging process><aging related><autophagy><balance><balance function><boost longevity><cell age><cellular age><computational modeling><computational models><computer based models><computerized modeling><decline in function><decline in functional status><defective proteostasis><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diabetes><driving><dynamic system><dynamical system><elongating the lifespan><enhance longevity><environmental change><environmental risk><experiment><experimental research><experimental study><experiments><extend life span><extend lifespan><extend longevity><ferroheme><foster longevity><functional decline><functional status decline><gene interaction><gene network><genetically engineered><hallmarks of aging><healthspan><healthy life span><hydroxymethylglutaryl-CoA-reductase kinase><improve lifespan><improve longevity><innovate><innovation><innovative><insoluble aggregate><intervention therapy><life span><lifespan><lifespan extension><malignancy><mitochondrial><model organism><multicatalytic endopeptidase complex><multidisciplinary><neoplasm/cancer><neurodegenerative illness><pace of aging><pace of biological aging><pathway><pillars of aging><population based><prolong lifespan><prolong longevity><promote lifespan><promote longevity><protein aggregate><protein aggregation><protein folding><protein homeostasis><protein homeostasis decline><protein homeostasis deficiency><protein homeostasis dysfunction><protein homeostasis failure><protein homeostasis loss><proteostasis><proteostasis decline><proteostasis defect><proteostasis deficiency><proteostasis dysfunction><proteostasis dysregulation><proteostasis failure><proteostasis impairment><proteostasis loss><proteotoxic><proteotoxicity><rDNA><rate of aging><rate of biological aging><replicative aging><sensor><social role><speed of aging><speed of the aging><stochastic method><success><support longevity><µfluidic>

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LORRAINE PILLUS

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$523,991

FY 2026

Project Title

Network-Driven Dynamics of Replicative Aging

Grant Number:

5R01AG056440-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary This project aims at integrating computational modeling and innovative measurement technologies to understand the complexity of single-cell aging and the emergent dynamics from the underlying regulatory networks. Aging is closely associated with many diseases, such cancer, diabetes,...

Research Terms

<(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase><20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><5'-AMP-activated protein kinase><AMP-activated kinase><AMP-activated protein kinase><AMPK enzyme><Affect><Aging><Automobile Driving><Autophagocytosis><Autoregulation><Baker's Yeast><Biology of Aging><Brewer's Yeast><Cancers><Cell Aging><Cell Body><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Chaperone><Complex><Computer Models><Computerized Models><Consumption><Data><Deacetylase><Degenerative Neurologic Disorders><Development><Diabetes Mellitus><Disease><Disorder><Environment><Environmental Factor><Environmental Risk Factor><Equilibrium><Eukaryota><Eukaryote><Ferroprotoporphyrin><Foundations><Funding><Gene Transcription><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><HMG CoA reductase (NADPH) kinase><HMG CoA reductase kinase><HMG coenzyme A reductase (NADPH) kinase><Heat Shock><Heat-Shock Reaction><Heat-Shock Response><Heme><Homeostasis><Human><Imaging technology><Incidence><Increase lifespan><Individual><Intermediary Metabolism><Intervention Strategies><L-Lysine><Length of Life><Longevity><Lysine><Macropain><Macroxyproteinase><Malignant Neoplasms><Malignant Tumor><Measurement><Mediating><Metabolic><Metabolic Processes><Metabolism><Microfluidics><Mitochondria><Modeling><Modern Man><Molecular><Molecular Chaperones><Multicatalytic Proteinase><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Nutrient><Pathway interactions><Phenotype><Physiological Homeostasis><Process><Production><Property><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteosome><Protoheme><RNA Expression><Recombinant DNA Technology><Regulation><Replicative Senescence><Research><Ribosomal DNA><Role><S cerevisiae><S. cerevisiae><Saccharomyces cerevisiae><Stochastic Processes><Stress><System><Systems Biology><Technology><Testing><Therapeutic Intervention><Transcription><Yeasts><abnormal protein homeostasis><abnormal proteostasis><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><aging associated><aging process><aging related><autophagy><balance><balance function><boost longevity><cell age><cellular age><computational modeling><computational models><computer based models><computerized modeling><decline in function><decline in functional status><defective proteostasis><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diabetes><driving><dynamic system><dynamical system><elongating the lifespan><enhance longevity><environmental change><environmental risk><experiment><experimental research><experimental study><experiments><extend life span><extend lifespan><extend longevity><ferroheme><foster longevity><functional decline><functional status decline><gene interaction><gene network><genetically engineered><hallmarks of aging><healthspan><healthy life span><hydroxymethylglutaryl-CoA-reductase kinase><improve lifespan><improve longevity><innovate><innovation><innovative><insoluble aggregate><intervention therapy><life span><lifespan><lifespan extension><malignancy><mitochondrial><model organism><multicatalytic endopeptidase complex><multidisciplinary><neoplasm/cancer><neurodegenerative illness><pace of aging><pace of biological aging><pathway><pillars of aging><population based><prolong lifespan><prolong longevity><promote lifespan><promote longevity><protein aggregate><protein aggregation><protein folding><protein homeostasis><protein homeostasis decline><protein homeostasis deficiency><protein homeostasis dysfunction><protein homeostasis failure><protein homeostasis loss><proteostasis><proteostasis decline><proteostasis defect><proteostasis deficiency><proteostasis dysfunction><proteostasis dysregulation><proteostasis failure><proteostasis impairment><proteostasis loss><proteotoxic><proteotoxicity><rDNA><rate of aging><rate of biological aging><replicative aging><sensor><social role><speed of aging><speed of the aging><stochastic method><success><support longevity><µfluidic>

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LEV S TSIMRING

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$523,991

FY 2026

Project Title

Network-Driven Dynamics of Replicative Aging

Grant Number:

5R01AG056440-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2017

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary This project aims at integrating computational modeling and innovative measurement technologies to understand the complexity of single-cell aging and the emergent dynamics from the underlying regulatory networks. Aging is closely associated with many diseases, such cancer, diabetes,...

Research Terms

<(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase><20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><5'-AMP-activated protein kinase><AMP-activated kinase><AMP-activated protein kinase><AMPK enzyme><Affect><Aging><Automobile Driving><Autophagocytosis><Autoregulation><Baker's Yeast><Biology of Aging><Brewer's Yeast><Cancers><Cell Aging><Cell Body><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Chaperone><Complex><Computer Models><Computerized Models><Consumption><Data><Deacetylase><Degenerative Neurologic Disorders><Development><Diabetes Mellitus><Disease><Disorder><Environment><Environmental Factor><Environmental Risk Factor><Equilibrium><Eukaryota><Eukaryote><Ferroprotoporphyrin><Foundations><Funding><Gene Transcription><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><HMG CoA reductase (NADPH) kinase><HMG CoA reductase kinase><HMG coenzyme A reductase (NADPH) kinase><Heat Shock><Heat-Shock Reaction><Heat-Shock Response><Heme><Homeostasis><Human><Imaging technology><Incidence><Increase lifespan><Individual><Intermediary Metabolism><Intervention Strategies><L-Lysine><Length of Life><Longevity><Lysine><Macropain><Macroxyproteinase><Malignant Neoplasms><Malignant Tumor><Measurement><Mediating><Metabolic><Metabolic Processes><Metabolism><Microfluidics><Mitochondria><Modeling><Modern Man><Molecular><Molecular Chaperones><Multicatalytic Proteinase><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Nutrient><Pathway interactions><Phenotype><Physiological Homeostasis><Process><Production><Property><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteosome><Protoheme><RNA Expression><Recombinant DNA Technology><Regulation><Replicative Senescence><Research><Ribosomal DNA><Role><S cerevisiae><S. cerevisiae><Saccharomyces cerevisiae><Stochastic Processes><Stress><System><Systems Biology><Technology><Testing><Therapeutic Intervention><Transcription><Yeasts><abnormal protein homeostasis><abnormal proteostasis><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><aging associated><aging process><aging related><autophagy><balance><balance function><boost longevity><cell age><cellular age><computational modeling><computational models><computer based models><computerized modeling><decline in function><decline in functional status><defective proteostasis><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diabetes><driving><dynamic system><dynamical system><elongating the lifespan><enhance longevity><environmental change><environmental risk><experiment><experimental research><experimental study><experiments><extend life span><extend lifespan><extend longevity><ferroheme><foster longevity><functional decline><functional status decline><gene interaction><gene network><genetically engineered><hallmarks of aging><healthspan><healthy life span><hydroxymethylglutaryl-CoA-reductase kinase><improve lifespan><improve longevity><innovate><innovation><innovative><insoluble aggregate><intervention therapy><life span><lifespan><lifespan extension><malignancy><mitochondrial><model organism><multicatalytic endopeptidase complex><multidisciplinary><neoplasm/cancer><neurodegenerative illness><pace of aging><pace of biological aging><pathway><pillars of aging><population based><prolong lifespan><prolong longevity><promote lifespan><promote longevity><protein aggregate><protein aggregation><protein folding><protein homeostasis><protein homeostasis decline><protein homeostasis deficiency><protein homeostasis dysfunction><protein homeostasis failure><protein homeostasis loss><proteostasis><proteostasis decline><proteostasis defect><proteostasis deficiency><proteostasis dysfunction><proteostasis dysregulation><proteostasis failure><proteostasis impairment><proteostasis loss><proteotoxic><proteotoxicity><rDNA><rate of aging><rate of biological aging><replicative aging><sensor><social role><speed of aging><speed of the aging><stochastic method><success><support longevity><µfluidic>

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Joo Eun Jung

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$513,251

FY 2026

Project Title

Pathobiology of ICH in Aging

Grant Number:

5R01NS133693-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/12/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Intracerebral hemorrhage (ICH) leads to severe brain damage, profound deficit, and death in ~40% of patients, and aging is a key risk factor for poor outcome. At least 30% of ICH patients develop lung injury, including lung infection and these patients have worse outcome. This implies that ...

Research Terms

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Mark E Kleinman

EAST TENNESSEE STATE UNIVERSITY, JOHNSON CITY, TN

Good lead · 66/100

Likely hiring

Above-average budget

Recent

Active award

$510,387

FY 2026

Project Title

Histone Expression in the Aging RPE

Grant Number:

5R01EY036138-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary (30 lines): Aging is a complex, multifactorial process wherein transcriptional reprogramming is accompanied by perturbations in the epigenome. We have performed experiments to determine the histone expression profile in the aging RPE and discovered an age-dependent loss of histone ex...

Research Terms

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JIANRONG LI

TEXAS A&M AGRILIFE RESEARCH, College Station, TX

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$499,587

FY 2026

Project Title

Role of glial sphingolipid ceramide in aging and Alzheimer's disease

Grant Number:

5R01AG079320-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Aging is the most prominent nongenetic risk factor for age-associated diseases including late onset Alzheimer’s disease (AD) and related dementias. Accumulating evidence has implicated altered sphingolipid ceramide pathways in aging and neurodegenerative diseases. However, the cellu...

Research Terms

<(TNF)-α><18 year old><18 years of age><AD and related dementia><AD brain><AD dementia><AD model><AD pathology><AD related dementia><AD risk><AD risk factor><ADRD><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's amyloid><Alzheimer's and related dementias><Alzheimer's brain><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease pathology><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's pathology><Alzheimers Dementia><Ammon Horn><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Amyloidosis><Anabolism><Animal Model><Animal Models and Related Studies><Area><Astrocytes><Astrocytus><Astroglia><Automobile Driving><Autoregulation><Aβ><Benign senescent forgetfulness><Brain><Brain Nervous System><Brain region><Cachectin><Carbon><Causality><Cell Aging><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Death><Cell Function><Cell Interaction><Cell Lineage><Cell Physiology><Cell Process><Cell Senescence><Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Cellular injury><Ceramides><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Cornu Ammonis><Data><Degenerative Neurologic Disorders><Demyelinations><Deposit><Deposition><Deterioration><Development><Disease><Disease Progression><Disorder><Disseminated Sclerosis><Disturbance in cognition><Dysfunction><Elderly><Encephalon><Etiology><Foundations><Functional disorder><GEM model><GEMM model><Genetically Engineered Mouse><Glia><Glial Cells><Goals><Hippocampus><Homeostasis><Hortega cell><Human><Hydrolysis><Immune Cell Activation><Impaired cognition><In Situ><Individual><Inflammasome><Inflammation><Inflammatory><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Leanness><Lipids><Lysosomes><Macrophage-Derived TNF><Mediating><Memory Deficit><Memory impairment><Metabolic Processes><Metabolism><Mice><Mice Mammals><Microglia><Modern Man><Molecular><Monocyte-Derived TNF><Multiple Sclerosis><Murine><Mus><Mutant Strains Mice><Myelin><Myelin Sheath><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroglia><Neuroglial Cells><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Non-neuronal cell><Nonneuronal cell><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Onset of illness><Pathogenesis><Pathogenicity><Pathology><Pathway interactions><Persons><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Play><Predisposition><Primary Senile Degenerative Dementia><Process><Production><Regulation><Replicative Senescence><Research><Risk Factors><Risk-associated variant><Role><Signal Transduction><Signal Transduction Systems><Signaling><Sphingolipids><Sphingomyelin Cholinephosphohydrolase><Sphingomyelin Cleaving Enzyme><Sphingomyelin Phosphodiesterase><Sphingomyelinase><Sphingomyelinase C><Sphingomyelins><Subcellular Process><Susceptibility><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Thinness><Time><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Upregulation><a beta peptide><abeta><abeta deposition><acid sphingomyelinase><advanced age><age 18><age 18 years><age associated><age associated cognitive impairment><age associated disease><age associated disorder><age associated impairment><age associated memory decline><age associated memory deficit><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age linked><age related><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related human disease><age related memory dysfunction><age related neurodegeneration><age related pathways><age specific><age-associated memory impairment><age-driven neurodegenerative disorders><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><age-related disease><age-related disorder><age-related impairment><age-related neurodegenerative disease><age-related neurodegenerative disorder><aged hippocampus><aged mice><aged mouse><ages><aging associated><aging associated mechanism><aging associated neurodegeneration><aging associated neurodegenerative disease><aging hippocampus><aging mechanism><aging pathway><aging related><aging related cognitive decline><aging related mechanism><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><aging related pathways><alzheimer model><alzheimer risk><amyloid beta><amyloid beta deposition><amyloid disease><amyloid pathology><amyloid β deposition><amyloid-b protein><astrocytic glia><aβ deposition><beta amyloid fibril><biological mechanism of age><biological pathways of age><biological signal transduction><biosynthesis><causation><cell damage><cell injury><cell type><cellular damage><ceramide synthase><cognitive defects><cognitive dysfunction><cognitive loss><conditional knock-out><conditional knockout><conditional mutant><conditional mutation><cytokine><damage to cells><declining cognitive functions with aging><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><demyelinate><developmental><dihydroceramide desaturase><disease causation><disease onset><disorder onset><driving><eighteen year old><eighteen years of age><elderly mice><extracellular><fat metabolism><gene manipulation><genetic manipulation><genetically engineered mouse model><genetically engineered murine model><genetically manipulate><genetically perturb><geriatric><gitter cell><glial activation><glial cell activation><hippocampal><immune activation><in vivo><injury to cells><insight><insular sclerosis><knock-down><knockdown><late onset alzheimer><lipid metabolism><lipidomics><mechanism regulating aging><mechanisms involved in aging><memory dysfunction><mesoglia><microglial cell><microgliocyte><model of animal><mouse model><mouse mutant><murine model><necrocytosis><nerve cement><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal><neuronal degeneration><non-demented><non-genetic><nondemented><nongenetic><novel><old mice><oligodendrocyte lineage><paracrine><pathophysiology><pathway><pathway involved in aging><perivascular glial cell><prevent><preventing><primary degenerative dementia><replicative aging><risk allele><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk gene><risk genotype><risk loci><risk locus><risk of developing Alzheimer's><risk variant><senile dementia of the Alzheimer type><senior citizen><social role><soluble amyloid precursor protein><substantia alba><transcriptomics><white matter><younger age>

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Kazuhide Hayakawa

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$470,786

FY 2026

Project Title

Aging Immunity to Extracellular Mitochondria Exacerbates Vascular Cognitive Impairment After Stroke

Grant Number:

5R01NS137979-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Aging immunity to extracellular mitochondria exacerbates vascular cognitive impairment after stroke The pathogenic mechanisms of vascular contributions to cognitive impairment and dementia (VCID) are poorly understood. Neurovascular inflammation is a key driver of VCID. There is also a large literat...

Research Terms

<7S Gamma Globulin><Acceleration><Aging><Anticardiolipin Antibodies><Antigen Presentation><Apoplexy><Astrocytes><Astrocytus><Astroglia><Blood Plasma><Brain><Brain Nervous System><Brain Vascular Accident><CNS plasticity><Causality><Cell Body><Cell Communication and Signaling><Cell Death><Cell Signaling><Cells><Cellular Immune Function><Cerebral Ischemia><Cerebral Stroke><Cerebral endothelium><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chemicals><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Common Rat Strains><Complement><Complement Proteins><Complex><D-Glucose><Data><Dextrose><Disturbance in cognition><Down-Regulation><Encephalon><Endothelial Cells><Endothelium><Etiology><Extracellular Space><Female><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Genetic><Glucose><Hortega cell><Human><IgG><Immune><Immune system><Immunes><Immunity><Immunoglobulin G><Impaired cognition><In Vitro><Inflammation><Innate Immunity><Intercellular Space><Intracellular Communication and Signaling><Link><Literature><Macrophage><Mediating><Methods><Mice><Mice Mammals><Microglia><Mitochondria><Mitochondria RNA><Mitochondrial RNA><Modern Man><Modification><Molecular><Motor><Murine><Mus><Mφ><Native Immunity><Natural Immunity><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurologic><Neurological><Neuronal Plasticity><Neurons><Non-Specific Immunity><Nonspecific Immunity><O element><O2 element><Opsonin><Outcome><Oxygen><Oxygen Consumption><Pathogenicity><Pathway interactions><Plasma><Plasma Serum><Process><Production><Proteins><RNA Seq><RNA sequencing><RNAseq><Rat><Rats Mammals><Rattus><Recombinant Proteins><Recycling><Rejuvenation><Reticuloendothelial System, Serum, Plasma><Severities><Short interfering RNA><Signal Transduction><Signal Transduction Systems><Signaling><Spleen><Spleen Reticuloendothelial System><Stroke><System><Testing><Therapeutic><Thrombus><Translations><Vascular Cognitive Impairment><adaptive immunity><after stroke><age associated><age associated alterations><age associated changes><age associated decline><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent decline><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related decline><age specific><age specific alterations><age specific changes><aged><aged brain><aged mice><aged mouse><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><astrocytic glia><behavior outcome><behavioral outcome><biological signal transduction><brain attack><brain endothelium><cardiac disease induced cognitive impairment><causation><central nervous system plasticity><cerebral vascular accident><cerebrovascular accident><cerebrovascular contribution to cognitive impairment><cerebrovascular contribution to cognitive impairment and dementia><cerebrovascular contributions to cognitive dysfunction><changes with age><cognitive decline after stroke><cognitive decline in stroke><cognitive dysfunction><cognitive dysfunction after stroke><cognitive dysfunction in stroke><cognitive impairment after stroke><cognitive impairment in stroke><cognitive loss><cognitive recovery><complementation><confocal imaging><cortical endothelium><decline with age><dementia after stroke><deprivation><disease causation><elderly mice><extracellular><flow cytophotometry><gain of function><gitter cell><immune function><improved><in vivo Model><inhibitor><loss of function><male><mesoglia><microglial cell><microgliocyte><mitochondrial><mitochondrial dysfunction><motor impairment><movement impairment><movement limitation><mtRNA><necrocytosis><nerve cell death><nerve cell loss><neural plasticity><neuro-vascular><neurological recovery><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal loss><neuroplastic><neuroplasticity><neuroprotection><neuroprotective><neurovascular><novel><old mice><pathway><perivascular glial cell><post stroke><post stroke cognitive decline><post stroke cognitive dysfunction><post stroke cognitive impairment><post stroke dementia><poststroke><poststroke cognitive decline><poststroke cognitive dysfunction><poststroke cognitive impairment><poststroke dementia><potential biological marker><potential biomarker><prevent><preventing><protein complex><response><siRNA><spatial and temporal><spatial temporal><spatiotemporal><stroked><strokes><tool><transcriptome sequencing><transcriptomic sequencing><translation><vascular and cognitive impairment><vascular cognition impairment><vascular cognitive decline><vascular cognitive disease><vascular cognitive disorder><vascular cognitive dysfunction><vascular cognitive impairment and dementia><vascular contribution to impairment or dementia><vascular contributions to cognition/dementia><vascular contributions to cognitive decline><vascular contributions to cognitive decline and dementia><vascular contributions to cognitive impairment><vascular contributions to cognitive impairment and dementia><vascular disease and impaired cognition><vascular dysfunction resulting in cognitive decline><vascular inflammation><vascular related cognitive decline><vascular related cognitive impairment><♀><♂>

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Matthias Arnold

DUKE UNIVERSITY, DURHAM, NC

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$452,943

FY 2026

Project Title

Metabolic age to define influences of the lipidome on brain aging in Alzheimer's disease

Grant Number:

5R01AG081322-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Evidence for the roles of lipids in brain aging and Alzheimer (AD) and its related dementias (ADRD) is building. Lipidomics is providing new insights related to altered lipid turnover and metabolism in AD and their roles in brain aging. Our AD Metabolomics Consortium (ADMC) led by MPI Kaddurah-Daouk...

Research Terms

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Rima F Kaddurah-Daouk

DUKE UNIVERSITY, DURHAM, NC

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$452,943

FY 2026

Project Title

Metabolic age to define influences of the lipidome on brain aging in Alzheimer's disease

Grant Number:

5R01AG081322-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Evidence for the roles of lipids in brain aging and Alzheimer (AD) and its related dementias (ADRD) is building. Lipidomics is providing new insights related to altered lipid turnover and metabolism in AD and their roles in brain aging. Our AD Metabolomics Consortium (ADMC) led by MPI Kaddurah-Daouk...

Research Terms

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PETER JOHN MEIKLE

DUKE UNIVERSITY, DURHAM, NC

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$452,943

FY 2026

Project Title

Metabolic age to define influences of the lipidome on brain aging in Alzheimer's disease

Grant Number:

5R01AG081322-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Evidence for the roles of lipids in brain aging and Alzheimer (AD) and its related dementias (ADRD) is building. Lipidomics is providing new insights related to altered lipid turnover and metabolism in AD and their roles in brain aging. Our AD Metabolomics Consortium (ADMC) led by MPI Kaddurah-Daouk...

Research Terms

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Timothy Lee Domeier

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$418,229

FY 2026

Project Title

Cardiomyocyte TRPV4 and Angiotensin-II induced ventricular arrhythmia with aging

Grant Number:

5R01HL136292-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/3/2017

End Date:

3/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Transient receptor potential vanilloid, member 4 (TRPV4) is a cation channel highly expressed in cardiomyocytes with aging, and contributes to enhanced cardiomyocyte calcium cycling and hypercontractility following TRPV4 gating stimuli including osmotic stress and mechanical...

Research Terms

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Jefferson Chan

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$411,542

FY 2026

Project Title

Chemical Probes for Studying Stem Cells and Environmental Interactions in Aging

Grant Number:

5R35GM133581-07

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2019

End Date:

3/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary / Abstract Stem cells are critical cell populations that maintain tissue health and regenerative capacity. Understanding the mechanisms leading to the decline of stem cell function can provide unique insights into how their regenerative abilities can be enhanced and prolonged to faci...

Research Terms

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Michael Buszczak

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$336,200

FY 2026

Project Title

Characterization of how mRNA translation influences reproductive aging

Grant Number:

5R01AG079513-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary Aging represents a major risk factor for a broad range of diseases and declines in tissue homeostasis and function. This is particularly true in the female reproductive system where the aging of stored oocytes has been directly linked with an increased incidence of miscarriages and birth def...

Research Terms

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Erika E Skoe

UNIVERSITY OF CONNECTICUT STORRS, STORRS-MANSFIELD, CT

Good lead · 66/100

Likely hiring

Solid budget

Very recent

Active award

$330,456

FY 2026

Project Title

The Noisy Life of the Musician: Implications for Healthy Brain Aging

Grant Number:

5R01AG075271-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/5/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Playing a musical instrument is a popular childhood and adult activity with documented health benefits. One of the most provocative, but least understood, proposed health benefits is preserved brain function in advanced age. Playing a musical instrument, however, can also pose signif...

Research Terms

<21+ years old><Accounting><Acoustics><Address><Adult><Adult Human><Age><Aging><Attention><Auditory><Auditory Evoked Potentials><Auditory Evoked Response><Auditory Threshold><Benefits and Risks><Biometrics><Biometry><Biostatistics><Brain><Brain Nervous System><Childhood><Clinical><Cochlea><Cochlear Organ><Communities><Confounding Factors (Epidemiology)><Confounding Variables><Data><Ear><Elderly><Encephalon><Environment><Epidemiologic Confounding Factor><Exposure to><Fortification><Health Benefit><Health Hazards><Hearing><Human><Injury><Interview><Investigation><Knowledge><Lead><Life><Link><Literature><Loudness><Measures><Medial><Mediating><Methodology><Methods><Modern Man><Music><Neurosciences><Noise><Noise-Induced Hearing Loss><Outcome><Pb element><Pilot Projects><Play><Prevention><Property><Publishing><Recommendation><Recurrence><Recurrent><Reflex><Reflex action><Research><Research Resources><Resources><Risk><Risk Factors><Selection Bias><Socio-economic status><Socioeconomic Status><Speech Perception><Structure><System><Testing><Therapeutic><Training><Work><accumulated exposure><accumulated long-term exposure><adult youth><adulthood><advanced age><age associated decline><age associated effects><age associated functional decline><age dependent decline><age dependent functional decline><age effect><age induced loss of function><age related decline><age related effects><age related functional decline><age-related loss of function><aged brain><ages><aggregate exposure><aging associated functional decline><aging brain><aging effect><aging induced functional decline><aging related functional decline><clinical significance><clinically significant><college><collegiate><compare to control><comparison control><cumulative exposure><cumulative life exposure><cumulative long-term exposure><decline in function><decline in functional status><decline with age><design><designing><dosimetry><functional decline><functional decline due to aging><functional decline with age><functional decline with aging><functional loss with aging><functional status decline><geriatric><good hearing><hazard><healthy aging><healthy hearing><healthy human aging><hearing loss risk><hearing threshold><heavy metal Pb><heavy metal lead><impact of age><improved><influence of age><injuries><innovate><innovation><innovative><instrument><life-course exposure><lifelong exposure><lifespan exposure><lifetime exposure><mid life><mid-life><middle age><middle aged><midlife><multidisciplinary><musician><neural><neural circuit><neural circuitry><neurocircuitry><new approaches><noise exposure><noise related hearing loss><noise-induced hearing impairment><normal hearing><novel><novel approaches><novel strategies><novel strategy><older adult><older adulthood><pediatric><pilot study><preservation><protective effect><risk for hearing loss><risk mitigation><risk of hearing loss><senior citizen><socio-economic position><socioeconomic position><sound><synaptic circuit><synaptic circuitry><totality of exposures><young adult><young adult age><young adulthood>

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Andreana Benitez

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$985,752

FY 2026

Project Title

Quantitative Neuroimaging Assessment of White Matter Integrity in the Context of Aging and AD

Grant Number:

5R01AG054159-09

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2017

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Although the most significant risk factor for developing Alzheimer’s disease (AD) is advanced age, the changes in tissue microstructure that signal the shift from normal aging to AD are not well understood. Thus, in response to PAR-22-093, NOT-AG-21-039: Understanding AD in the Conte...

Research Terms

<3-D><3-Dimensional><3D><AD biological marker><AD biomarker><AD dementia><AD related biomarker><AD risk><AD risk factor><Active Follow-up><Address><Age><Aging><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease related biomarker><Alzheimer's disease risk><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><Amentia><Ammon Horn><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Assay><Axon><Aβ><Bioassay><Biological Assay><Biological Markers><Body Tissues><Brain><Brain Nervous System><Cell Communication and Signaling><Cell Signaling><Clinical><Clinical Research><Clinical Study><Clinical Trials><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><DWI (diffusion weighted imaging)><DWI-MRI><Data><Dementia><Diffusion><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Disease><Disease Progression><Disorder><Disturbance in cognition><Elderly><Encephalon><Failure><Fiber><Funding><Geometry><Glia><Glial Cells><Gliosis><Goals><Grant><Health><Hippocampus><Hydrogen Oxide><Image><Impaired cognition><Inflammation><Innate Immunity><Intracellular Communication and Signaling><Knowledge><Kolliker's reticulum><Lesion><Long-term cohort><Long-term cohort study><Longitudinal Studies><Longitudinal Surveys><Longitudinal cohort><Longitudinal cohort study><MR Imaging><MR Spectroscopy><MR Tomography><MRI><MRI biomarker><MRI marker><MRIs><Magnetic Resonance Imaging><Magnetic Resonance Spectroscopy><Maintenance><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Microscopic><Modeling><Monitor><Myelin><Myelin Water Imaging><N-acetyl aspartate><N-acetyl-L-aspartate><N-acetylaspartate><NMR Imaging><NMR Tomography><Native Immunity><Natural History><Natural Immunity><Nerve Degeneration><Neuroglia><Neuroglial Cells><Neuron Degeneration><Neuropsychologic Tests><Neuropsychological Tests><Non-Specific Immunity><Non-neuronal cell><Nonneuronal cell><Nonspecific Immunity><Nuclear Magnetic Resonance Imaging><Outcome Study><PET><PET Scan><PET imaging><PETSCAN><PETT><Participant><Pathologic><Phase><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Primary Senile Degenerative Dementia><Procedures><Process><Questionnaires><Rad.-PET><Relaxation><Sample Size><Signal Transduction><Signal Transduction Systems><Signaling><Structure><Techniques><Testing><Time><Tissues><Visualization><Water><Work><Zeugmatography><a beta peptide><aberrant aging><abeta><abnormal aging><active followup><advanced age><age associated><age correlated><age dependent><age linked><age related><age specific><aged brain><ages><aging brain><alzheimer risk><amyloid beta><amyloid imaging><amyloid pathology><amyloid-b protein><asymptomatic Alzheimer's><asymptomatic Alzheimer's disease><beta amyloid associated pathology><beta amyloid fibril><beta amyloid pathology><bio-markers><biologic marker><biological signal transduction><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><biophysical model><clinical relevance><clinically relevant><cognitive dysfunction><cognitive loss><cohort><dMRI><data modeling><density><develop therapy><diffused><diffuses><diffusing><diffusion tensor imaging><diffusions><dysfunctional age related change><dysfunctional aging><follow up><follow-up><followed up><followup><geriatric><hippocampal><imaging><impaired aging><innovate><innovation><innovative><intervention development><long-term study><longitudinal outcome studies><longitudinal research study><magnetic resonance imaging biomarker><magnetic resonance imaging marker><maladaptive aging><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><model of data><model the data><modeling of the data><myoinositol><natural aging><nerve cement><neural degeneration><neural imaging><neuro-imaging><neurodegeneration><neurodegenerative><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological degeneration><neurological imaging><neuronal degeneration><normal aging><normative aging><pandemic><pandemic disease><pathological age related changes><pathological aging><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><pre-clinical therapy><preclinical><preclinical therapy><prevent><preventing><primary degenerative dementia><recruit><repair><repaired><response><retention rate><retention strategy><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senescence><senescent><senile dementia of the Alzheimer type><senior citizen><soluble amyloid precursor protein><substantia alba><therapy development><three dimensional><treatment development><trend><white matter><white matter change><β-amyloid pathology>

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FEI DU

MCLEAN HOSPITAL, BELMONT, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$888,999

FY 2026

Project Title

Molecular Mechanisms of Aging in Schizophrenia: Implications of Bioenergetic Metabolism and Redox Biology

Grant Number:

5R01MH135093-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Schizophrenia (SZ) is a devastating psychiatric disorder that brings heavy burden to health care systems. A large literature indicates that individuals with SZ show markers of early aging, such as faster decline in cognitive functioning, increased risk for dementia, and significantly...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><ADP Phosphocreatine Phosphotransferase><ATP Creatine Phosphotransferase><ATP Synthesis><ATP Synthesis Pathway><ATP phosphohydrolase><ATPase><Acceleration><Active Follow-up><Address><Adenosine Triphosphatase><Affect><Age><Age Years><Aging><Amentia><Aminalon><Aminalone><Antioxidants><Antipsychotic Agents><Antipsychotic Drugs><Antipsychotics><Automobile Driving><Biochemical><Bioenergetics><Biological Markers><Biology><Blood><Blood Reticuloendothelial System><Blood Sample><Blood Vessels><Blood specimen><Brain><Brain Nervous System><Brain Pathology><Brain region><Cardiovascular Diseases><Cerebrovascular Circulation><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical assessments><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cohort Effect><Communication><Communities><Creatine Kinase><Creatine Kinase-B><Creatine Kinase-B Chain><Creatine Phosphokinase><Data><Data Set><Degenerative Neurologic Disorders><Dementia><Development><Diabetes Mellitus><Disease><Disorder><Distant><Disturbance in cognition><Drugs><Dysfunction><Encephalon><Energy Expenditure><Energy Metabolism><Ensure><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Future><GABA><Generation Effect><Glutamates><Glutathione><Glycolysis><Goals><H+ element><Health Care Systems><Hospitals><Hydrogen Ions><Image><Impaired cognition><Impairment><Individual><Inflammatory><Intermediary Metabolism><Intervention><L-Glutamate><Lead><Life><Life Expectancy><Life Style><Lifestyle><Link><Literature><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Major Tranquilizers><Major Tranquilizing Agents><Measures><Medial><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Mental disorders><Mental health disorders><Metabolic><Metabolic Processes><Metabolic syndrome><Metabolism><Mitochondria><Modality><Molecular><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><NADH><NIMH><NMDA Receptor-Ionophore Complex><NMDA Receptors><NMR Imaging><NMR Tomography><National Institute of Mental Health><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurobiology><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroleptic Agents><Neuroleptic Drugs><Neuroleptics><Neurologic Degenerative Conditions><Neuronal Dysfunction><Neurons><Nuclear Magnetic Resonance Imaging><Obesity><Older Population><Oxidation-Reduction><Pathologic><Pathology><Pathway interactions><Patient Recruitments><Patients><Pb element><Persons><Pharmaceutical Preparations><Phase><Phosphorous><Phosphorus><Physiopathology><Prefrontal Cortex><Premature Aging><Premature aging syndrome><Process><Protons><Psychiatric Disease><Psychiatric Disorder><Psychoses><RNA Splicing><Redox><Research><Rest><Risk Factors><Risk Reduction><Role><Schizophrenia><Schizophrenic Disorders><Sedentary behavior><Sedentary life-style><Smoking><Societies><Splicing><Survivors><Symptoms><Tobacco smoking><Tobacco smoking behavior><Toxic effect><Toxicities><Work><Zeugmatography><aberrant aging><abnormal aging><abnormal brain function><accelerated aging><accelerated biological age><accelerated biological aging><active followup><adiposity><age acceleration><age related pathways><ages><aging associated mechanism><aging mechanism><aging pathway><aging related mechanism><aging related pathways><bio-markers><biologic marker><biological mechanism of age><biological pathways of age><biomarker><blood flow in brain><brain atrophy><brain blood circulation><brain blood flow><brain control><brain dysfunction><brain impairment><brain metabolism><cardiometabolic><cardiometabolism><cardiovascular disorder><cerebral atrophy><cerebral blood flow><cerebral circulation><cerebrocirculation><cerebrovascular blood flow><chronic disorder><clinical phenotype><cognitive assessment><cognitive dysfunction><cognitive function><cognitive loss><cognitive testing><cohort><comparative><corpulence><cortical atrophy><decline in function><decline in functional status><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><dementia praecox><dementia risk><design><designing><developmental><diabetes><driving><drug/agent><dysfunctional age related change><dysfunctional aging><dysfunctional brain><early psychosis><fMRI><follow up><follow-up><followed up><followup><functional decline><functional status decline><gamma-Aminobutyric Acid><gamma-L-Glu-L-Cys-Gly><gamma-L-Glutamyl-L-Cysteinylglycine><glutamatergic><healthy aging><healthy human aging><heavy metal Pb><heavy metal lead><imaging><impaired aging><in vivo><information processing><insight><interest><late in life><late life><later in life><later life><life span><lifespan><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><maladaptive aging><mechanism regulating aging><mechanisms involved in aging><mental illness><mitochondrial><mortality><myoinositol><neural dysfunction><neural imaging><neural inflammation><neuro-imaging><neurobiological><neurobiological mechanism><neurochemical><neurochemistry><neurodegenerative illness><neuroimaging><neuroinflammation><neuroinflammatory><neurological imaging><neuronal><novel><older groups><older individuals><older person><oxidation reduction reaction><pace of aging><pace of biological aging><participant recruitment><pathological age related changes><pathological aging><pathophysiology><pathway><pathway involved in aging><premature><prematurity><psychiatric illness><psychological disorder><rate of aging><rate of biological aging><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><repair><repaired><response><risk factor for dementia><risk for dementia><risk-reducing><schizophrenia spectrum><schizophrenia spectrum disorder><schizophrenic><sedentary lifestyle><sex><side effect><social role><speed of aging><speed of the aging><structural imaging><treatment effect><vascular><γ-Aminobutyric Acid>

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Dost Ongur

MCLEAN HOSPITAL, BELMONT, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$888,999

FY 2026

Project Title

Molecular Mechanisms of Aging in Schizophrenia: Implications of Bioenergetic Metabolism and Redox Biology

Grant Number:

5R01MH135093-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Schizophrenia (SZ) is a devastating psychiatric disorder that brings heavy burden to health care systems. A large literature indicates that individuals with SZ show markers of early aging, such as faster decline in cognitive functioning, increased risk for dementia, and significantly...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><ADP Phosphocreatine Phosphotransferase><ATP Creatine Phosphotransferase><ATP Synthesis><ATP Synthesis Pathway><ATP phosphohydrolase><ATPase><Acceleration><Active Follow-up><Address><Adenosine Triphosphatase><Affect><Age><Age Years><Aging><Amentia><Aminalon><Aminalone><Antioxidants><Antipsychotic Agents><Antipsychotic Drugs><Antipsychotics><Automobile Driving><Biochemical><Bioenergetics><Biological Markers><Biology><Blood><Blood Reticuloendothelial System><Blood Sample><Blood Vessels><Blood specimen><Brain><Brain Nervous System><Brain Pathology><Brain region><Cardiovascular Diseases><Cerebrovascular Circulation><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical assessments><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cohort Effect><Communication><Communities><Creatine Kinase><Creatine Kinase-B><Creatine Kinase-B Chain><Creatine Phosphokinase><Data><Data Set><Degenerative Neurologic Disorders><Dementia><Development><Diabetes Mellitus><Disease><Disorder><Distant><Disturbance in cognition><Drugs><Dysfunction><Encephalon><Energy Expenditure><Energy Metabolism><Ensure><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Future><GABA><Generation Effect><Glutamates><Glutathione><Glycolysis><Goals><H+ element><Health Care Systems><Hospitals><Hydrogen Ions><Image><Impaired cognition><Impairment><Individual><Inflammatory><Intermediary Metabolism><Intervention><L-Glutamate><Lead><Life><Life Expectancy><Life Style><Lifestyle><Link><Literature><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Major Tranquilizers><Major Tranquilizing Agents><Measures><Medial><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Mental disorders><Mental health disorders><Metabolic><Metabolic Processes><Metabolic syndrome><Metabolism><Mitochondria><Modality><Molecular><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><NADH><NIMH><NMDA Receptor-Ionophore Complex><NMDA Receptors><NMR Imaging><NMR Tomography><National Institute of Mental Health><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurobiology><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroleptic Agents><Neuroleptic Drugs><Neuroleptics><Neurologic Degenerative Conditions><Neuronal Dysfunction><Neurons><Nuclear Magnetic Resonance Imaging><Obesity><Older Population><Oxidation-Reduction><Pathologic><Pathology><Pathway interactions><Patient Recruitments><Patients><Pb element><Persons><Pharmaceutical Preparations><Phase><Phosphorous><Phosphorus><Physiopathology><Prefrontal Cortex><Premature Aging><Premature aging syndrome><Process><Protons><Psychiatric Disease><Psychiatric Disorder><Psychoses><RNA Splicing><Redox><Research><Rest><Risk Factors><Risk Reduction><Role><Schizophrenia><Schizophrenic Disorders><Sedentary behavior><Sedentary life-style><Smoking><Societies><Splicing><Survivors><Symptoms><Tobacco smoking><Tobacco smoking behavior><Toxic effect><Toxicities><Work><Zeugmatography><aberrant aging><abnormal aging><abnormal brain function><accelerated aging><accelerated biological age><accelerated biological aging><active followup><adiposity><age acceleration><age related pathways><ages><aging associated mechanism><aging mechanism><aging pathway><aging related mechanism><aging related pathways><bio-markers><biologic marker><biological mechanism of age><biological pathways of age><biomarker><blood flow in brain><brain atrophy><brain blood circulation><brain blood flow><brain control><brain dysfunction><brain impairment><brain metabolism><cardiometabolic><cardiometabolism><cardiovascular disorder><cerebral atrophy><cerebral blood flow><cerebral circulation><cerebrocirculation><cerebrovascular blood flow><chronic disorder><clinical phenotype><cognitive assessment><cognitive dysfunction><cognitive function><cognitive loss><cognitive testing><cohort><comparative><corpulence><cortical atrophy><decline in function><decline in functional status><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><dementia praecox><dementia risk><design><designing><developmental><diabetes><driving><drug/agent><dysfunctional age related change><dysfunctional aging><dysfunctional brain><early psychosis><fMRI><follow up><follow-up><followed up><followup><functional decline><functional status decline><gamma-Aminobutyric Acid><gamma-L-Glu-L-Cys-Gly><gamma-L-Glutamyl-L-Cysteinylglycine><glutamatergic><healthy aging><healthy human aging><heavy metal Pb><heavy metal lead><imaging><impaired aging><in vivo><information processing><insight><interest><late in life><late life><later in life><later life><life span><lifespan><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><maladaptive aging><mechanism regulating aging><mechanisms involved in aging><mental illness><mitochondrial><mortality><myoinositol><neural dysfunction><neural imaging><neural inflammation><neuro-imaging><neurobiological><neurobiological mechanism><neurochemical><neurochemistry><neurodegenerative illness><neuroimaging><neuroinflammation><neuroinflammatory><neurological imaging><neuronal><novel><older groups><older individuals><older person><oxidation reduction reaction><pace of aging><pace of biological aging><participant recruitment><pathological age related changes><pathological aging><pathophysiology><pathway><pathway involved in aging><premature><prematurity><psychiatric illness><psychological disorder><rate of aging><rate of biological aging><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><repair><repaired><response><risk factor for dementia><risk for dementia><risk-reducing><schizophrenia spectrum><schizophrenia spectrum disorder><schizophrenic><sedentary lifestyle><sex><side effect><social role><speed of aging><speed of the aging><structural imaging><treatment effect><vascular><γ-Aminobutyric Acid>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

TOWIA A. LIBERMANN

BETH ISRAEL DEACONESS MEDICAL CENTER, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$846,502

FY 2026

Project Title

AD/ADRD and biological aging proteomic signatures in the etiopathology of delirium and its associated long-term cognitive decline

Grant Number:

5R01AG051658-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2015

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Delirium (acute confusion), is a major complication of surgery in older patients, strongly associated with long term cognitive decline (LTCD) and Alzheimer's Disease and Related Dementias (AD/ADRD). Prevention of postoperative delirium and its long-term complications would b...

Research Terms

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EDWARD R MARCANTONIO

BETH ISRAEL DEACONESS MEDICAL CENTER, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$846,502

FY 2026

Project Title

AD/ADRD and biological aging proteomic signatures in the etiopathology of delirium and its associated long-term cognitive decline

Grant Number:

5R01AG051658-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2015

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Delirium (acute confusion), is a major complication of surgery in older patients, strongly associated with long term cognitive decline (LTCD) and Alzheimer's Disease and Related Dementias (AD/ADRD). Prevention of postoperative delirium and its long-term complications would b...

Research Terms

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Lisa M Ellerby

BUCK INSTITUTE FOR RESEARCH ON AGING, NOVATO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$809,486

FY 2026

Project Title

Role of OXR1 and the retromer in brain aging and Alzheimer's disease and related dementias

Grant Number:

1R01AG095381-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Although some genetic risk factors for AD are known, the precise etiology of most cases of late-onset Alzheimer's disease (AD) is unknown. Unfortunately, AD therapies have been largely unsuccessful. Two important risk factors for AD, aging, and diet, remain poorly understood...

Research Terms

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Pankaj Kapahi

BUCK INSTITUTE FOR RESEARCH ON AGING, NOVATO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$809,486

FY 2026

Project Title

Role of OXR1 and the retromer in brain aging and Alzheimer's disease and related dementias

Grant Number:

1R01AG095381-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Although some genetic risk factors for AD are known, the precise etiology of most cases of late-onset Alzheimer's disease (AD) is unknown. Unfortunately, AD therapies have been largely unsuccessful. Two important risk factors for AD, aging, and diet, remain poorly understood...

Research Terms

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Andrew S Fox

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$803,128

FY 2026

Project Title

Brain Aging Across the Lifespan in Neurodevelopmental Disorders

Grant Number:

5R01MH133068-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/20/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Autism spectrum disorder (ASD) is typically described as a disorder of childhood; however, challenges in socioemotional behavior and cognition persist across the lifespan. Nearly 6 million adults in the United States currently live with ASD, with prevalence more than doubling in the last 10...

Research Terms

<12-20 years old><21+ years old><ASD><Adolescence><Adult><Adult Human><Affect><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer beta-Protein><Alzheimer's Amyloid beta-Protein><Alzheimer's amyloid><Amentia><Ammon Horn><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Anterior><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Array tomography><Assay><Autism><Autistic Disorder><Autopsy><Aβ><Aβ burden><Behavioral><Benign senescent forgetfulness><Bioassay><Biological Assay><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Count><Cell Nucleus><Cell Number><Cell Signaling><Cells><Cellular injury><Childhood><Chronic><Clinical><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Cornu Ammonis><Data><Dementia><Development><Disease><Disorder><Disturbance in cognition><Dysfunction><Early Infantile Autism><Emotional><Encephalon><Encephalon Diseases><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Functional disorder><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Goals><Growth><Hippocampus><Hortega cell><Human><IFN-Gamma-Inducing Factor Gene><IFN-gamma-Inducing Factor><IGIF><IGIF Gene><IL-1 Gamma><IL-1 Gamma Gene><IL-18><IL-18 Gene><IL-1g><IL-1g Gene><IL18><IL18 Protein><IL18 gene><IL1F4><IL1F4 Gene><Immune Cell Activation><Immunofluorescence><Immunofluorescence Immunologic><Immunoglobulin Enhancer-Binding Protein><Impaired cognition><Impairment><Infantile Autism><Inflammatory><Interferon-Gamma-Inducing Factor Gene><Interferon-gamma-Inducing Factor><Interleukin 18 (Interferon-Gamma-Inducing Factor)><Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene><Interleukin 18 Proprotein><Interleukin 18 Proprotein Gene><Interleukin-1 Gamma><Interleukin-1 Gamma Gene><Interleukin-18><Interleukin-18 Precursor><Interleukin-18 Precursor Gene><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><MGC12320><MGC12320 Gene><MT-bound tau><Maps><Medial><Methods><Microglia><Modern Man><Molecular><Myelin><NF-kB><NF-kappa B><NF-kappaB><NFKB><Nerve Cells><Nerve Degeneration><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neuroimmune><Neurological Development Disorder><Neuron Degeneration><Neuronal Transmission><Neurons><Neuropil><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Nucleus><Pathogenicity><Pathologic><Pathway interactions><Pattern><Phenotype><Physiopathology><Population><Prevalence><Process><Proteins><Proteomics><Publishing><RNA Expression><Receptor Protein><Regulatory Pathway><Research><Risk><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Spinal Column><Spine><Staining method><Stains><Stress><Structure><Study models><Synapses><Synaptic><System><Techniques><Thick><Thickness><Tissue Growth><Transcript><Transcription><Transcription Factor NF-kB><United States><Vertebral column><a beta peptide><a-beta burden><aberrant aging><abeta><abeta accumulation><abeta aggregation><abeta burden><abnormal aging><adolescence (12-20)><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age associated><age associated alterations><age associated changes><age associated cognitive impairment><age associated difference><age associated memory decline><age associated memory deficit><age based difference><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent difference><age dependent variation><age difference><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related difference><age related memory dysfunction><age related variation><age specific><age specific alterations><age specific changes><age specific difference><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><aged brain><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related cognitive decline><aging specific alterations><aging specific changes><alterations with age><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid burden><amyloid β accumulation><amyloid β aggregation><amyloid-b protein><autism spectral disorder><autism spectrum disorder><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><aβ accumulation><aβ aggregation><backbone><beta amyloid burden><beta amyloid fibril><biological signal transduction><brain control><brain tissue><brain volume><cell damage><cell injury><cell type><cellular damage><changes with age><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cognitive dysfunction><cognitive loss><comparative><cytokine><damage to cells><data reduction><declining cognitive functions with aging><density><developmental><differ by age><difference across age><difference in age><differential expression><differentially expressed><dysfunctional age related change><dysfunctional aging><early adulthood><emerging adult><emotional behavior><genetic information><gitter cell><glia signaling><glial signaling><healthspan extending intervention><healthspan extending therapies><healthspan intervention><healthspan promoting intervention><healthspan promoting therapies><healthspan therapies><healthy aging><healthy aging intervention><healthy human aging><hippocampal><immune activation><impaired aging><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><injury to cells><insoluble aggregate><intervention to promote healthy aging><interventions to improve healthspan><kappa B Enhancer Binding Protein><life span><lifespan><maladaptive aging><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><model of animal><necropsy><nerve signaling><neural degeneration><neural inflammation><neural signaling><neurobiological><neurodegeneration><neurodegenerative><neurodevelopmental disease><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal><neuronal degeneration><neuronal signaling><neuropathologic><neuropathological><neuropathology><neurotransmission><novel><nuclear factor kappa beta><ontogeny><pathological age related changes><pathological aging><pathophysiology><pathway><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><perivascular glial cell><postmortem><precision medicine><precision-based medicine><preservation><protein aggregate><protein aggregation><receptor><response><sNuc-Seq><sex><single molecule><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><soluble amyloid precursor protein><super high resolution><superresolution><synapse><tau><tau Proteins><tau factor><transcriptional differences><transcriptomics><ultra high resolution><variation by age><β-amyloid burden><βamyloid burden><τ Proteins>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

KARL Daniel MURRAY

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$803,128

FY 2026

Project Title

Brain Aging Across the Lifespan in Neurodevelopmental Disorders

Grant Number:

5R01MH133068-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/20/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Autism spectrum disorder (ASD) is typically described as a disorder of childhood; however, challenges in socioemotional behavior and cognition persist across the lifespan. Nearly 6 million adults in the United States currently live with ASD, with prevalence more than doubling in the last 10...

Research Terms

<12-20 years old><21+ years old><ASD><Adolescence><Adult><Adult Human><Affect><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer beta-Protein><Alzheimer's Amyloid beta-Protein><Alzheimer's amyloid><Amentia><Ammon Horn><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Anterior><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Array tomography><Assay><Autism><Autistic Disorder><Autopsy><Aβ><Aβ burden><Behavioral><Benign senescent forgetfulness><Bioassay><Biological Assay><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Count><Cell Nucleus><Cell Number><Cell Signaling><Cells><Cellular injury><Childhood><Chronic><Clinical><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Cornu Ammonis><Data><Dementia><Development><Disease><Disorder><Disturbance in cognition><Dysfunction><Early Infantile Autism><Emotional><Encephalon><Encephalon Diseases><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Functional disorder><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Goals><Growth><Hippocampus><Hortega cell><Human><IFN-Gamma-Inducing Factor Gene><IFN-gamma-Inducing Factor><IGIF><IGIF Gene><IL-1 Gamma><IL-1 Gamma Gene><IL-18><IL-18 Gene><IL-1g><IL-1g Gene><IL18><IL18 Protein><IL18 gene><IL1F4><IL1F4 Gene><Immune Cell Activation><Immunofluorescence><Immunofluorescence Immunologic><Immunoglobulin Enhancer-Binding Protein><Impaired cognition><Impairment><Infantile Autism><Inflammatory><Interferon-Gamma-Inducing Factor Gene><Interferon-gamma-Inducing Factor><Interleukin 18 (Interferon-Gamma-Inducing Factor)><Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene><Interleukin 18 Proprotein><Interleukin 18 Proprotein Gene><Interleukin-1 Gamma><Interleukin-1 Gamma Gene><Interleukin-18><Interleukin-18 Precursor><Interleukin-18 Precursor Gene><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><MGC12320><MGC12320 Gene><MT-bound tau><Maps><Medial><Methods><Microglia><Modern Man><Molecular><Myelin><NF-kB><NF-kappa B><NF-kappaB><NFKB><Nerve Cells><Nerve Degeneration><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neuroimmune><Neurological Development Disorder><Neuron Degeneration><Neuronal Transmission><Neurons><Neuropil><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Nucleus><Pathogenicity><Pathologic><Pathway interactions><Pattern><Phenotype><Physiopathology><Population><Prevalence><Process><Proteins><Proteomics><Publishing><RNA Expression><Receptor Protein><Regulatory Pathway><Research><Risk><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Spinal Column><Spine><Staining method><Stains><Stress><Structure><Study models><Synapses><Synaptic><System><Techniques><Thick><Thickness><Tissue Growth><Transcript><Transcription><Transcription Factor NF-kB><United States><Vertebral column><a beta peptide><a-beta burden><aberrant aging><abeta><abeta accumulation><abeta aggregation><abeta burden><abnormal aging><adolescence (12-20)><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age associated><age associated alterations><age associated changes><age associated cognitive impairment><age associated difference><age associated memory decline><age associated memory deficit><age based difference><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent difference><age dependent variation><age difference><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related difference><age related memory dysfunction><age related variation><age specific><age specific alterations><age specific changes><age specific difference><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><aged brain><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related cognitive decline><aging specific alterations><aging specific changes><alterations with age><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid burden><amyloid β accumulation><amyloid β aggregation><amyloid-b protein><autism spectral disorder><autism spectrum disorder><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><aβ accumulation><aβ aggregation><backbone><beta amyloid burden><beta amyloid fibril><biological signal transduction><brain control><brain tissue><brain volume><cell damage><cell injury><cell type><cellular damage><changes with age><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cognitive dysfunction><cognitive loss><comparative><cytokine><damage to cells><data reduction><declining cognitive functions with aging><density><developmental><differ by age><difference across age><difference in age><differential expression><differentially expressed><dysfunctional age related change><dysfunctional aging><early adulthood><emerging adult><emotional behavior><genetic information><gitter cell><glia signaling><glial signaling><healthspan extending intervention><healthspan extending therapies><healthspan intervention><healthspan promoting intervention><healthspan promoting therapies><healthspan therapies><healthy aging><healthy aging intervention><healthy human aging><hippocampal><immune activation><impaired aging><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><injury to cells><insoluble aggregate><intervention to promote healthy aging><interventions to improve healthspan><kappa B Enhancer Binding Protein><life span><lifespan><maladaptive aging><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><model of animal><necropsy><nerve signaling><neural degeneration><neural inflammation><neural signaling><neurobiological><neurodegeneration><neurodegenerative><neurodevelopmental disease><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal><neuronal degeneration><neuronal signaling><neuropathologic><neuropathological><neuropathology><neurotransmission><novel><nuclear factor kappa beta><ontogeny><pathological age related changes><pathological aging><pathophysiology><pathway><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><perivascular glial cell><postmortem><precision medicine><precision-based medicine><preservation><protein aggregate><protein aggregation><receptor><response><sNuc-Seq><sex><single molecule><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><soluble amyloid precursor protein><super high resolution><superresolution><synapse><tau><tau Proteins><tau factor><transcriptional differences><transcriptomics><ultra high resolution><variation by age><β-amyloid burden><βamyloid burden><τ Proteins>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Cynthia Schumann

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$803,128

FY 2026

Project Title

Brain Aging Across the Lifespan in Neurodevelopmental Disorders

Grant Number:

5R01MH133068-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/20/2023

End Date:

10/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Autism spectrum disorder (ASD) is typically described as a disorder of childhood; however, challenges in socioemotional behavior and cognition persist across the lifespan. Nearly 6 million adults in the United States currently live with ASD, with prevalence more than doubling in the last 10...

Research Terms

<12-20 years old><21+ years old><ASD><Adolescence><Adult><Adult Human><Affect><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer beta-Protein><Alzheimer's Amyloid beta-Protein><Alzheimer's amyloid><Amentia><Ammon Horn><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Anterior><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Array tomography><Assay><Autism><Autistic Disorder><Autopsy><Aβ><Aβ burden><Behavioral><Benign senescent forgetfulness><Bioassay><Biological Assay><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Count><Cell Nucleus><Cell Number><Cell Signaling><Cells><Cellular injury><Childhood><Chronic><Clinical><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collection><Cornu Ammonis><Data><Dementia><Development><Disease><Disorder><Disturbance in cognition><Dysfunction><Early Infantile Autism><Emotional><Encephalon><Encephalon Diseases><FISH Technic><FISH Technique><FISH analysis><FISH assay><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Functional disorder><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Goals><Growth><Hippocampus><Hortega cell><Human><IFN-Gamma-Inducing Factor Gene><IFN-gamma-Inducing Factor><IGIF><IGIF Gene><IL-1 Gamma><IL-1 Gamma Gene><IL-18><IL-18 Gene><IL-1g><IL-1g Gene><IL18><IL18 Protein><IL18 gene><IL1F4><IL1F4 Gene><Immune Cell Activation><Immunofluorescence><Immunofluorescence Immunologic><Immunoglobulin Enhancer-Binding Protein><Impaired cognition><Impairment><Infantile Autism><Inflammatory><Interferon-Gamma-Inducing Factor Gene><Interferon-gamma-Inducing Factor><Interleukin 18 (Interferon-Gamma-Inducing Factor)><Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene><Interleukin 18 Proprotein><Interleukin 18 Proprotein Gene><Interleukin-1 Gamma><Interleukin-1 Gamma Gene><Interleukin-18><Interleukin-18 Precursor><Interleukin-18 Precursor Gene><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Kanner's Syndrome><Knowledge><MGC12320><MGC12320 Gene><MT-bound tau><Maps><Medial><Methods><Microglia><Modern Man><Molecular><Myelin><NF-kB><NF-kappa B><NF-kappaB><NFKB><Nerve Cells><Nerve Degeneration><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neuroimmune><Neurological Development Disorder><Neuron Degeneration><Neuronal Transmission><Neurons><Neuropil><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Nucleus><Pathogenicity><Pathologic><Pathway interactions><Pattern><Phenotype><Physiopathology><Population><Prevalence><Process><Proteins><Proteomics><Publishing><RNA Expression><Receptor Protein><Regulatory Pathway><Research><Risk><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Spinal Column><Spine><Staining method><Stains><Stress><Structure><Study models><Synapses><Synaptic><System><Techniques><Thick><Thickness><Tissue Growth><Transcript><Transcription><Transcription Factor NF-kB><United States><Vertebral column><a beta peptide><a-beta burden><aberrant aging><abeta><abeta accumulation><abeta aggregation><abeta burden><abnormal aging><adolescence (12-20)><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age associated><age associated alterations><age associated changes><age associated cognitive impairment><age associated difference><age associated memory decline><age associated memory deficit><age based difference><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent difference><age dependent variation><age difference><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related difference><age related memory dysfunction><age related variation><age specific><age specific alterations><age specific changes><age specific difference><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><aged brain><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging related cognitive decline><aging specific alterations><aging specific changes><alterations with age><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid burden><amyloid β accumulation><amyloid β aggregation><amyloid-b protein><autism spectral disorder><autism spectrum disorder><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><axon signaling><axon-glial signaling><axonal signaling><aβ accumulation><aβ aggregation><backbone><beta amyloid burden><beta amyloid fibril><biological signal transduction><brain control><brain tissue><brain volume><cell damage><cell injury><cell type><cellular damage><changes with age><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><cognitive dysfunction><cognitive loss><comparative><cytokine><damage to cells><data reduction><declining cognitive functions with aging><density><developmental><differ by age><difference across age><difference in age><differential expression><differentially expressed><dysfunctional age related change><dysfunctional aging><early adulthood><emerging adult><emotional behavior><genetic information><gitter cell><glia signaling><glial signaling><healthspan extending intervention><healthspan extending therapies><healthspan intervention><healthspan promoting intervention><healthspan promoting therapies><healthspan therapies><healthy aging><healthy aging intervention><healthy human aging><hippocampal><immune activation><impaired aging><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><injury to cells><insoluble aggregate><intervention to promote healthy aging><interventions to improve healthspan><kappa B Enhancer Binding Protein><life span><lifespan><maladaptive aging><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><model of animal><necropsy><nerve signaling><neural degeneration><neural inflammation><neural signaling><neurobiological><neurodegeneration><neurodegenerative><neurodevelopmental disease><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal><neuronal degeneration><neuronal signaling><neuropathologic><neuropathological><neuropathology><neurotransmission><novel><nuclear factor kappa beta><ontogeny><pathological age related changes><pathological aging><pathophysiology><pathway><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><perivascular glial cell><postmortem><precision medicine><precision-based medicine><preservation><protein aggregate><protein aggregation><receptor><response><sNuc-Seq><sex><single molecule><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><soluble amyloid precursor protein><super high resolution><superresolution><synapse><tau><tau Proteins><tau factor><transcriptional differences><transcriptomics><ultra high resolution><variation by age><β-amyloid burden><βamyloid burden><τ Proteins>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Lisa Feldman Barrett

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$787,806

FY 2026

Project Title

Biopsychosocial Mechanisms of Successful Aging

Grant Number:

5R01AG071173-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

It is well-known that in most people, cognitive abilities decline with age. With the elderly population growing (20% of Americans will be over 65 by 2030), this represents a significant public health concern. However, not all older adults show this pattern of decline. We and others have demonstrated...

Research Terms

<21+ years old><AD biological marker><AD biomarker><AD dementia><AD related biomarker><Adult><Adult Human><Affect><Affective><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease related biomarker><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><American><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Amyloid><Amyloid Substance><Anatomic Sites><Anatomic structures><Anatomy><Arousal><Autonomic nervous system><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Benign senescent forgetfulness><Biological><Biological Markers><Body System><Brain><Brain Nervous System><Cardiac Output><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Communication><Conditioning Therapy><Deterioration><Development><Dimensions><Disturbance in cognition><Dysfunction><Elderly><Enabling Factors><Encephalon><Exercise><Exhibits><Functional disorder><Funding><Goals><Health><Heterogeneity><Impaired cognition><Impairment><Individual><Individual Differences><Intervention><Intervention Studies><Measures><Memory><Modeling><Motivation><Neurobiology><Organ System><Organism-Level Process><Organismal Process><Outcome><Outcome Measure><Outcomes Research><Participant><Pattern><Performance><Persons><Physiologic><Physiologic Processes><Physiological><Physiological Processes><Physiopathology><Population><Primary Senile Degenerative Dementia><Public Health><Research><Role><Sampling><Structure><Subgroup><Testing><Vascular resistance><Visceral><adult youth><adulthood><advanced age><age associated><age associated cognitive impairment><age associated decline><age associated memory decline><age associated memory deficit><age correlated><age dependent><age dependent decline><age linked><age related><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related decline><age related memory dysfunction><age specific><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><ages><aging related cognitive decline><amygdaloid nuclear complex><behavior intervention><behavior measurement><behavioral intervention><behavioral measure><behavioral measurement><bio-markers><biobehavior><biobehavioral><biologic><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><biopsychosocial><build resilience><build resiliency><cognitive ability><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive task><decline with age><declining cognitive functions with aging><develop resilience><develop resiliency><developmental><enhance resilience><enhance resiliency><experience><facilitate resilience><geriatric><healthy aging><healthy human aging><heart output><improve resilience><improve resiliency><improved><increase resilience><increase resiliency><individual heterogeneity><individual variability><individual variation><innovate><innovation><innovative><insight><intervention research><interventional research><interventional study><interventions research><life style intervention><lifestyle intervention><measurable outcome><neural><neural imaging><neural mechanism><neural patterning><neuro-imaging><neurobiological><neuroimaging><neurological imaging><neuromechanism><neuropathologic><neuropathological><neuropathology><new approaches><novel approaches><novel strategies><novel strategy><older adult><older adulthood><outcome measurement><pathophysiology><potential biological marker><potential biomarker><pre-clinical><preclinical><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><preservation><primary degenerative dementia><promote resilience><promote resiliency><protective factors><psychologic><psychological><resilience><resilience development><resilient><response><senile dementia of the Alzheimer type><senior citizen><social role><young adult><young adult age><young adulthood>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

BRADFORD C DICKERSON

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$787,806

FY 2026

Project Title

Biopsychosocial Mechanisms of Successful Aging

Grant Number:

5R01AG071173-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

It is well-known that in most people, cognitive abilities decline with age. With the elderly population growing (20% of Americans will be over 65 by 2030), this represents a significant public health concern. However, not all older adults show this pattern of decline. We and others have demonstrated...

Research Terms

<21+ years old><AD biological marker><AD biomarker><AD dementia><AD related biomarker><Adult><Adult Human><Affect><Affective><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's biomarker><Alzheimer's disease biological marker><Alzheimer's disease biomarker><Alzheimer's disease related biomarker><Alzheimer's related biomarker><Alzheimers Dementia><Alzheimer’s biological marker><American><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Amyloid><Amyloid Substance><Anatomic Sites><Anatomic structures><Anatomy><Arousal><Autonomic nervous system><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Benign senescent forgetfulness><Biological><Biological Markers><Body System><Brain><Brain Nervous System><Cardiac Output><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Communication><Conditioning Therapy><Deterioration><Development><Dimensions><Disturbance in cognition><Dysfunction><Elderly><Enabling Factors><Encephalon><Exercise><Exhibits><Functional disorder><Funding><Goals><Health><Heterogeneity><Impaired cognition><Impairment><Individual><Individual Differences><Intervention><Intervention Studies><Measures><Memory><Modeling><Motivation><Neurobiology><Organ System><Organism-Level Process><Organismal Process><Outcome><Outcome Measure><Outcomes Research><Participant><Pattern><Performance><Persons><Physiologic><Physiologic Processes><Physiological><Physiological Processes><Physiopathology><Population><Primary Senile Degenerative Dementia><Public Health><Research><Role><Sampling><Structure><Subgroup><Testing><Vascular resistance><Visceral><adult youth><adulthood><advanced age><age associated><age associated cognitive impairment><age associated decline><age associated memory decline><age associated memory deficit><age correlated><age dependent><age dependent decline><age linked><age related><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related decline><age related memory dysfunction><age specific><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><ages><aging related cognitive decline><amygdaloid nuclear complex><behavior intervention><behavior measurement><behavioral intervention><behavioral measure><behavioral measurement><bio-markers><biobehavior><biobehavioral><biologic><biologic marker><biomarker><biomarker in AD><biomarker in Alzheimer's><biomarker in Alzheimer's disease><biopsychosocial><build resilience><build resiliency><cognitive ability><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive task><decline with age><declining cognitive functions with aging><develop resilience><develop resiliency><developmental><enhance resilience><enhance resiliency><experience><facilitate resilience><geriatric><healthy aging><healthy human aging><heart output><improve resilience><improve resiliency><improved><increase resilience><increase resiliency><individual heterogeneity><individual variability><individual variation><innovate><innovation><innovative><insight><intervention research><interventional research><interventional study><interventions research><life style intervention><lifestyle intervention><measurable outcome><neural><neural imaging><neural mechanism><neural patterning><neuro-imaging><neurobiological><neuroimaging><neurological imaging><neuromechanism><neuropathologic><neuropathological><neuropathology><new approaches><novel approaches><novel strategies><novel strategy><older adult><older adulthood><outcome measurement><pathophysiology><potential biological marker><potential biomarker><pre-clinical><preclinical><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><preservation><primary degenerative dementia><promote resilience><promote resiliency><protective factors><psychologic><psychological><resilience><resilience development><resilient><response><senile dementia of the Alzheimer type><senior citizen><social role><young adult><young adult age><young adulthood>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Rose Ellen Dixon

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$740,899

FY 2026

Project Title

Molecular choreography and trafficking in the aging myocardium

Grant Number:

5R01AG063796-07

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2019

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Aging is an independent risk factor for cardiovascular disease and with an aging global population there is an urgent need to increase health-span alongside the already increased lifespan, allowing people to live independent and healthy lives well into their old age. Cardiac aging is...

Research Terms

View Full Project Details on NIH Reporter

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SCOTT A SUMMERS

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$736,859

FY 2026

Project Title

Targeting Ceramide Signaling: Enhancing Healthy Aging and Combating Tauopathy in Mammals

Grant Number:

5R01AG085793-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The study investigates the association between growth hormone deficiency and longevity in mouse models. We discovered that GHRH-KO mice with extended lifespans have different circulating lipid profiles, with ceramides being the most significantly altered lipid class. Ceramides have been implicated i...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Age related pathologies><Aging><American><Anabolism><Animal Model><Animal Models and Related Studies><Animals><Apoptosis><Apoptosis Pathway><Assay><Autoregulation><Bioassay><Biological Assay><Body Tissues><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Senescence><Cell Signaling><Cells><Cellular Aging><Cellular Senescence><Ceramides><Clinical><Clinical Trials><Collaborations><Collection><Coupled><DNA Therapy><Diastolic heart failure><Diet><Drug Therapy><Dysfunction><Elderly><Enzyme Gene><Enzymes><Fatty Liver><Functional disorder><GHRH><GRH><Gene Transfer Clinical><Genetic><Genetic Intervention><Growth Hormone><Growth Hormone 1><Growth Hormone-Releasing Factor><Growth Hormone-Releasing Hormone><HF with preserved ejection fraction><HFpEF><Health><Health Care><Homeostasis><Impairment><Increase lifespan><Inflammation><Insulin Resistance><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><Investigation><KO mice><Knock-out Mice><Knockout Mice><Length of Life><Link><Lipids><Liver Steatosis><Longevity><Mammalia><Mammals><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondria><Modeling><Molecular><Murine><Mus><Null Mouse><Outcome><Pathway interactions><Pharmacological Treatment><Pharmacotherapy><Physiologic><Physiological><Physiological Homeostasis><Physiology><Physiopathology><Pituitary Growth Hormone><Position><Positioning Attribute><Pre-Clinical Model><Preclinical Models><Programmed Cell Death><Proteome><Proteomics><Publishing><Replicative Senescence><Research><Research Resources><Resources><Role><Signal Induction><Signal Transduction><Signal Transduction Systems><Signaling><Solubility><Somatocrinin><Somatoliberin><Somatotropin><Somatotropin-Releasing Hormone><Tauopathies><Techniques><Testing><Tissues><accelerated aging><accelerated biological age><accelerated biological aging><adulthood><advanced age><age acceleration><age associated disease><age associated disorder><age associated impairment><age associated pathologies><age dependent disease><age dependent disorder><age dependent impairment><age dependent pathologies><age induced pathologies><age related human disease><age-related disease><age-related disorder><age-related impairment><aging associated><aging associated pathologies><aging delay><aging dependent pathologies><aging induced pathologies><aging pathologies><aging prevention><aging process><aging related><aging related pathologies><anti aging><anti geronic><antiaging><attenuate aging><biological signal transduction><biosynthesis><boost longevity><ceramide synthase><clinical development><clinical relevance><clinically relevant><cognitive function><cost efficient><decelerate aging><delay age related><desaturase><determine efficacy><diets><dihydroceramide desaturase><double bond><drug candidate><drug intervention><drug treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><elongating the lifespan><enhance healthspan><enhance longevity><evaluate efficacy><examine efficacy><extend healthspan><extend life span><extend lifespan><extend longevity><extending healthy lifespan><foster longevity><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><geriatric><growth hormone deficiency><healthspan><healthspan extension><healthy aging><healthy human aging><healthy life span><heart failure with preserved ejection fraction><heart failure with preserved systolic function><hepatic steatosis><hepatosteatosis><hormonal signals><hormone signals><improve healthspan><improve lifespan><improve longevity><improved><increase healthspan><inhibitor><innovate><innovation><innovative><insight><insulin resistant><insulin tolerance><life span><lifespan><lifespan extension><lipidomics><mitochondrial><mitochondrial dysfunction><model of animal><mouse model><murine model><mutant><neuropathologic tau><neuropathological tau><neuroprotection><neuroprotective><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><overexpress><overexpression><pathophysiology><pathway><pause aging><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pi bond><postpone age related><preserved ejection fraction heart failure><prevent age related><prevent aging><prolong healthspan><prolong lifespan><prolong longevity><promote healthspan><promote lifespan><promote longevity><protection pathway><protective pathway><replicative aging><retards aging><senior citizen><slow aging><slow down aging><slow the rate of aging><social role><somatotropic hormone><support longevity><suppress aging><synergism><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic evaluation><therapeutic testing>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Liou Sun

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$736,859

FY 2026

Project Title

Targeting Ceramide Signaling: Enhancing Healthy Aging and Combating Tauopathy in Mammals

Grant Number:

5R01AG085793-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The study investigates the association between growth hormone deficiency and longevity in mouse models. We discovered that GHRH-KO mice with extended lifespans have different circulating lipid profiles, with ceramides being the most significantly altered lipid class. Ceramides have been implicated i...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Age related pathologies><Aging><American><Anabolism><Animal Model><Animal Models and Related Studies><Animals><Apoptosis><Apoptosis Pathway><Assay><Autoregulation><Bioassay><Biological Assay><Body Tissues><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Senescence><Cell Signaling><Cells><Cellular Aging><Cellular Senescence><Ceramides><Clinical><Clinical Trials><Collaborations><Collection><Coupled><DNA Therapy><Diastolic heart failure><Diet><Drug Therapy><Dysfunction><Elderly><Enzyme Gene><Enzymes><Fatty Liver><Functional disorder><GHRH><GRH><Gene Transfer Clinical><Genetic><Genetic Intervention><Growth Hormone><Growth Hormone 1><Growth Hormone-Releasing Factor><Growth Hormone-Releasing Hormone><HF with preserved ejection fraction><HFpEF><Health><Health Care><Homeostasis><Impairment><Increase lifespan><Inflammation><Insulin Resistance><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><Investigation><KO mice><Knock-out Mice><Knockout Mice><Length of Life><Link><Lipids><Liver Steatosis><Longevity><Mammalia><Mammals><Metabolic><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mitochondria><Modeling><Molecular><Murine><Mus><Null Mouse><Outcome><Pathway interactions><Pharmacological Treatment><Pharmacotherapy><Physiologic><Physiological><Physiological Homeostasis><Physiology><Physiopathology><Pituitary Growth Hormone><Position><Positioning Attribute><Pre-Clinical Model><Preclinical Models><Programmed Cell Death><Proteome><Proteomics><Publishing><Replicative Senescence><Research><Research Resources><Resources><Role><Signal Induction><Signal Transduction><Signal Transduction Systems><Signaling><Solubility><Somatocrinin><Somatoliberin><Somatotropin><Somatotropin-Releasing Hormone><Tauopathies><Techniques><Testing><Tissues><accelerated aging><accelerated biological age><accelerated biological aging><adulthood><advanced age><age acceleration><age associated disease><age associated disorder><age associated impairment><age associated pathologies><age dependent disease><age dependent disorder><age dependent impairment><age dependent pathologies><age induced pathologies><age related human disease><age-related disease><age-related disorder><age-related impairment><aging associated><aging associated pathologies><aging delay><aging dependent pathologies><aging induced pathologies><aging pathologies><aging prevention><aging process><aging related><aging related pathologies><anti aging><anti geronic><antiaging><attenuate aging><biological signal transduction><biosynthesis><boost longevity><ceramide synthase><clinical development><clinical relevance><clinically relevant><cognitive function><cost efficient><decelerate aging><delay age related><desaturase><determine efficacy><diets><dihydroceramide desaturase><double bond><drug candidate><drug intervention><drug treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><elongating the lifespan><enhance healthspan><enhance longevity><evaluate efficacy><examine efficacy><extend healthspan><extend life span><extend lifespan><extend longevity><extending healthy lifespan><foster longevity><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><geriatric><growth hormone deficiency><healthspan><healthspan extension><healthy aging><healthy human aging><healthy life span><heart failure with preserved ejection fraction><heart failure with preserved systolic function><hepatic steatosis><hepatosteatosis><hormonal signals><hormone signals><improve healthspan><improve lifespan><improve longevity><improved><increase healthspan><inhibitor><innovate><innovation><innovative><insight><insulin resistant><insulin tolerance><life span><lifespan><lifespan extension><lipidomics><mitochondrial><mitochondrial dysfunction><model of animal><mouse model><murine model><mutant><neuropathologic tau><neuropathological tau><neuroprotection><neuroprotective><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><overexpress><overexpression><pathophysiology><pathway><pause aging><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pi bond><postpone age related><preserved ejection fraction heart failure><prevent age related><prevent aging><prolong healthspan><prolong lifespan><prolong longevity><promote healthspan><promote lifespan><promote longevity><protection pathway><protective pathway><replicative aging><retards aging><senior citizen><slow aging><slow down aging><slow the rate of aging><social role><somatotropic hormone><support longevity><suppress aging><synergism><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic evaluation><therapeutic testing>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Nadia Razaq Sutton

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$734,957

FY 2026

Project Title

Probing mechanistic links between endothelial aging and dementia

Grant Number:

1R01AG092663-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The mission of our laboratory is to pursue answers to essential questions in the field vascular aging that will advance our basic understanding and translate into more effective treatments to optimize human vascular healthspan. The central thesis of this project is that endothelial c...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD and related dementia><AD dementia><AD related dementia><ADRD><ANG-2 Gene><ANGPT2><ANGPT2 gene><Achievement><Achievement Attainment><Address><Adult><Adult Human><Age><Aged 65 and Over><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><Ang-2><Ang2><Angiopoietin 2 Gene><Angiopoietin-2><Arteriosclerotic Dementia><Benchmarking><Best Practice Analysis><Biological><Biological Aging><Biological Function><Biological Process><Biology><Blood - brain barrier anatomy><Blood Vessels><Blood-Brain Barrier><Brain Vascular Disorders><Cell Aging><Cell Body><Cell Differentiation><Cell Differentiation process><Cell Line><Cell Senescence><Cell model><CellLine><Cells><Cellular Aging><Cellular Senescence><Cellular model><Cerebrovascular Disease><Cerebrovascular Disorders><Chronology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Computer Models><Computerized Models><Data><Data Set><Dementia><Development><Disease><Disorder><Disturbance in cognition><Dysfunction><Endothelial Cells><Endothelium><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Food and Drug Administration><Foundations><Functional disorder><Future><Genes><Genetic><GrimAge clock><Hannum clock><Hemato-Encephalic Barrier><Horvath clock><Human><Impaired cognition><Impairment><In Vitro><Individual><Intervention><Intracranial Vascular Diseases><Intracranial Vascular Disorders><Laboratories><Libraries><Link><Methodology><Mission><Mitochondria><Modeling><Modern Man><Outcome><Oxidative Stress><PBMC><Pathology><Peripheral Blood Mononuclear Cell><PhenoAge clocks><Physiopathology><Primary Senile Degenerative Dementia><Proteins><Proteomics><Regenerative Medicine><Replicative Senescence><Research><Source><Strains Cell Lines><Study models><Surface><Technology><Testing><Therapeutic><Translating><USFDA><United States Food and Drug Administration><Validation><Vascular Dementia><Vascular Diseases><Vascular Disorder><Vascular Endothelial Cell><Vascular aging><Work><above age 65><adult youth><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age correlated><age dependent><age linked><age of 65 years onward><age related><age related pathways><age specific><aged 65 and greater><aged 65+><aged brain><aged ≥65><ages><aging associated mechanism><aging brain><aging mechanism><aging pathway><aging process><aging related mechanism><aging related pathways><angiogenesis><benchmark><biologic><biological age><biological development><biological mechanism of age><biological pathways of age><biological process of age><biosignature><blood vessel disorder><bloodbrain barrier><brain vascular disease><brain vascular dysfunction><cardiac disease induced cognitive impairment><cell type><cellular differentiation><cerebral vascular disease><cerebral vascular dysfunction><cerebrovascular contribution to cognitive impairment and dementia><cerebrovascular contributions to dementia><cerebrovascular dysfunction><clinical center><cognitive dysfunction><cognitive loss><computational modeling><computational models><computer based models><computer based prediction><computerized modeling><cultured cell line><data pipeline><developmental><differentiation of pluripotent stem cells><effective therapy><effective treatment><endothelial dysfunction><epigenetic age clocks><epigenetic clock><epigenetic molecular clocks><epigenetically><experiment><experimental research><experimental study><experiments><hallmarks of aging><healthspan><healthy life span><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><human old age (65+)><iPS><iPSC><iPSCs><in vitro Model><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><internet portal><intracranial vascular dysfunction><mechanism regulating aging><mechanisms involved in aging><methylation clock><mitochondrial><multi-scale computational modeling><multi-scale mathematical modeling><multi-scale modeling><multiomics><multiple omics><multiscale computational modeling><multiscale mathematical modeling><multiscale modeling><novel><older adult><older adulthood><on-line portal><online portal><over 65 years><panomics><pathophysiology><pathway involved in aging><pillars of aging><pluripotent stem cell differentiation><predictive modeling><primary degenerative dementia><progenitor biology><progenitor cell biology><replicative aging><response><senescence><senescent><senile dementia of the Alzheimer type><stem and progenitor biology><stem cell biology><synthetic biology><transcriptomics><validations><vascular><vascular cognitive impairment and dementia><vascular contribution to impairment or dementia><vascular contributions in dementia><vascular contributions to cognition/dementia><vascular contributions to cognitive decline and dementia><vascular contributions to cognitive impairment and dementia><vascular contributions to dementia><vascular dysfunction><vascular related dementia><vasculature aging><vasculopathy><web portal><web-based portal><young adult><young adult age><young adulthood><≥65 years>

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Matthew J Campen

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$726,158

FY 2026

Project Title

Acceleration of Circulatory and Neurological Aging due to Wildfire Exposures

Grant Number:

5R01AG070776-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY: Acceleration of Circulatory and Neurological Aging due to Wildfire Exposures Wildfires pose an increasing threat to a growing and aging global population, notably in the Western United States. Little is known about the influence of inhaled environmental pollutants, such as from wildfire smo...

Research Terms

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ANDREW K OTTENS

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$726,158

FY 2026

Project Title

Acceleration of Circulatory and Neurological Aging due to Wildfire Exposures

Grant Number:

5R01AG070776-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY: Acceleration of Circulatory and Neurological Aging due to Wildfire Exposures Wildfires pose an increasing threat to a growing and aging global population, notably in the Western United States. Little is known about the influence of inhaled environmental pollutants, such as from wildfire smo...

Research Terms

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Liam J Holt

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$708,137

FY 2026

Project Title

Technologies to probe the biophysical properties of aging cells

Grant Number:

1R01AG090618-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY: The physical properties of the cell interior are crucial for the organization and efficiency of biochemical reactions. The highly crowded and non-thermodynamically equilibrated cellular environment can both enhance binding, and impede particle motion, thereby altering the efficiency of bioc...

Research Terms

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Jesse Meyer

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$698,690

FY 2026

Project Title

Molecular Mechanisms of Fiber Type-Specific Skeletal Muscle Dysfunction with Aging

Grant Number:

1R01AG086469-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Human aging is accompanied by a loss of skeletal muscle mass (sarcopenia) that is vastly exceeded by the ability to generate power (dynapenia), and the problem is exacerbated by the increased fatigability (activity- induced reduction in power) when older adults perform dynamic exercise. Th...

Research Terms

<3-D><3-Dimensional><3D><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Acceleration><Affect><Aged 65 and Over><Aging><Atrophic><Atrophy><Automobile Driving><Biological><Biopsy><Body Tissues><Cardiovascular Diseases><Cellular Mechanotransduction><Cellular Stress><Cellular Stress Response><Complex><Confocal Microscopy><Coupled><Data><Development><Diabetes Mellitus><Differences between sexes><Differs between sexes><Disease><Disorder><Dysfunction><Elderly><Exercise><Extremities><Female><Fiber><Functional disorder><Goals><Health Care><Health Care Costs><Health Costs><Human><Immunofluorescence><Immunofluorescence Immunologic><Impairment><Individual><Isoforms><Knowledge><LC/MS><Lead><Life><Limb structure><Limbs><Machine Learning><Measurement><Measures><Mechanical Signal Transduction><Mechanics><Mechanosensory Transduction><Mediating><Metabolic><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Molecular Target><Morphology><Muscle><Muscle Fibers><Muscle Tissue><Muscle function><Myosin Heavy Chains><Myotubes><Non-Trunk><Outcome><Output><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Pathway interactions><Pb element><Phenotype><Physical Function><Physiopathology><Property><Protein Isoforms><Proteins><Proteome><Proteomics><Public Health><QOL><QOL improvement><Quality of life><Research><Rhabdomyocyte><Sex Differences><Sexual differences><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Technology><Testing><Therapeutic Intervention><Tissues><Translating><Voluntary Muscle><above age 65><active life style><active lifestyle><active living><advanced age><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age associated alterations><age associated changes><age associated difference><age associated effects><age associated muscle atrophy><age based difference><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent difference><age dependent variation><age difference><age effect><age induced alterations><age induced changes><age linked><age of 65 years onward><age related><age related alterations><age related changes><age related difference><age related effects><age related pathways><age related variation><age specific><age specific alterations><age specific changes><age specific difference><age-associated decline in muscle><age-associated muscle decline><age-associated muscle deterioration><age-associated muscle loss><age-associated muscle wasting><age-related decline in muscle><age-related muscle decline><age-related muscle deterioration><age-related muscle loss><age-related muscle wasting><aged 65 and greater><aged 65+><aged ≥65><aging associated alterations><aging associated changes><aging associated mechanism><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging mechanism><aging pathway><aging prevention><aging process><aging related alterations><aging related changes><aging related mechanism><aging related pathways><aging specific alterations><aging specific changes><alterations with age><amino acid metabolism><anti aging><anti geronic><antiaging><biologic><biological adaptation to stress><biological mechanism of age><biological pathways of age><cardiovascular disorder><cell stress><changes with age><clinical relevance><clinical significance><clinically relevant><clinically significant><decreased muscle strength><developmental><diabetes><differ by age><difference across age><difference in age><disparate effect><disparate impact><disparate result><driving><dynapenia><fall risk><fatty acid oxidation><geriatric><heavy metal Pb><heavy metal lead><human old age (65+)><impact of age><improved><improved mobility><improvements in QOL><improvements in quality of life><inequitable effect><inequitable impact><inequitable outcome><influence of age><innovate><innovation><innovative><intervention therapy><life span><lifespan><liquid chromatography mass spectrometry><low muscle strength><machine based learning><male><mechanic><mechanical><mechanism regulating aging><mechanisms involved in aging><mechanosensing><mechanotransduction><mobility enhancement><mobility improvement><molecular profile><molecular signature><muscle bulk><muscle form><muscle mass><muscle strength decline><muscular><myosin heavy chain><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><older adult><older adulthood><optimized mobility><outcome disparities><outcome inequality><outcome inequity><over 65 years><pathophysiology><pathway><pathway involved in aging><preservation><prevent age related><prevent aging><protein homeostasis><proteostasis><quality of life improvement><reactioncrisis><reduced muscle strength><risk mitigation><sarcopenia><sarcopenic><senior citizen><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><skeletal muscle atrophy><skeletal muscle breakdown><skeletal muscle loss><skeletal muscle protein loss><skeletal muscle wasting><stress response><stressreaction><suppress aging><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><three dimensional><unequal effect><unequal impact><unequal outcome><variation by age><vastus lateralis><≥65 years><♀><♂>

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Christopher Sundberg

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$698,690

FY 2026

Project Title

Molecular Mechanisms of Fiber Type-Specific Skeletal Muscle Dysfunction with Aging

Grant Number:

1R01AG086469-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Human aging is accompanied by a loss of skeletal muscle mass (sarcopenia) that is vastly exceeded by the ability to generate power (dynapenia), and the problem is exacerbated by the increased fatigability (activity- induced reduction in power) when older adults perform dynamic exercise. Th...

Research Terms

<3-D><3-Dimensional><3D><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Acceleration><Affect><Aged 65 and Over><Aging><Atrophic><Atrophy><Automobile Driving><Biological><Biopsy><Body Tissues><Cardiovascular Diseases><Cellular Mechanotransduction><Cellular Stress><Cellular Stress Response><Complex><Confocal Microscopy><Coupled><Data><Development><Diabetes Mellitus><Differences between sexes><Differs between sexes><Disease><Disorder><Dysfunction><Elderly><Exercise><Extremities><Female><Fiber><Functional disorder><Goals><Health Care><Health Care Costs><Health Costs><Human><Immunofluorescence><Immunofluorescence Immunologic><Impairment><Individual><Isoforms><Knowledge><LC/MS><Lead><Life><Limb structure><Limbs><Machine Learning><Measurement><Measures><Mechanical Signal Transduction><Mechanics><Mechanosensory Transduction><Mediating><Metabolic><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Molecular Target><Morphology><Muscle><Muscle Fibers><Muscle Tissue><Muscle function><Myosin Heavy Chains><Myotubes><Non-Trunk><Outcome><Output><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Pathway interactions><Pb element><Phenotype><Physical Function><Physiopathology><Property><Protein Isoforms><Proteins><Proteome><Proteomics><Public Health><QOL><QOL improvement><Quality of life><Research><Rhabdomyocyte><Sex Differences><Sexual differences><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Technology><Testing><Therapeutic Intervention><Tissues><Translating><Voluntary Muscle><above age 65><active life style><active lifestyle><active living><advanced age><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age associated alterations><age associated changes><age associated difference><age associated effects><age associated muscle atrophy><age based difference><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent difference><age dependent variation><age difference><age effect><age induced alterations><age induced changes><age linked><age of 65 years onward><age related><age related alterations><age related changes><age related difference><age related effects><age related pathways><age related variation><age specific><age specific alterations><age specific changes><age specific difference><age-associated decline in muscle><age-associated muscle decline><age-associated muscle deterioration><age-associated muscle loss><age-associated muscle wasting><age-related decline in muscle><age-related muscle decline><age-related muscle deterioration><age-related muscle loss><age-related muscle wasting><aged 65 and greater><aged 65+><aged ≥65><aging associated alterations><aging associated changes><aging associated mechanism><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging mechanism><aging pathway><aging prevention><aging process><aging related alterations><aging related changes><aging related mechanism><aging related pathways><aging specific alterations><aging specific changes><alterations with age><amino acid metabolism><anti aging><anti geronic><antiaging><biologic><biological adaptation to stress><biological mechanism of age><biological pathways of age><cardiovascular disorder><cell stress><changes with age><clinical relevance><clinical significance><clinically relevant><clinically significant><decreased muscle strength><developmental><diabetes><differ by age><difference across age><difference in age><disparate effect><disparate impact><disparate result><driving><dynapenia><fall risk><fatty acid oxidation><geriatric><heavy metal Pb><heavy metal lead><human old age (65+)><impact of age><improved><improved mobility><improvements in QOL><improvements in quality of life><inequitable effect><inequitable impact><inequitable outcome><influence of age><innovate><innovation><innovative><intervention therapy><life span><lifespan><liquid chromatography mass spectrometry><low muscle strength><machine based learning><male><mechanic><mechanical><mechanism regulating aging><mechanisms involved in aging><mechanosensing><mechanotransduction><mobility enhancement><mobility improvement><molecular profile><molecular signature><muscle bulk><muscle form><muscle mass><muscle strength decline><muscular><myosin heavy chain><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><older adult><older adulthood><optimized mobility><outcome disparities><outcome inequality><outcome inequity><over 65 years><pathophysiology><pathway><pathway involved in aging><preservation><prevent age related><prevent aging><protein homeostasis><proteostasis><quality of life improvement><reactioncrisis><reduced muscle strength><risk mitigation><sarcopenia><sarcopenic><senior citizen><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><skeletal muscle atrophy><skeletal muscle breakdown><skeletal muscle loss><skeletal muscle protein loss><skeletal muscle wasting><stress response><stressreaction><suppress aging><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><three dimensional><unequal effect><unequal impact><unequal outcome><variation by age><vastus lateralis><≥65 years><♀><♂>

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Alan A. Cohen

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$690,865

FY 2026

Project Title

Mitochondrial and energetic underpinnings of resilience in human aging: integrating genetic and epidemiological evidence

Grant Number:

1R01AG092819-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Geroscience proposes that an understanding of the basic biology of aging will lead to interventions on the aging process which can thereby reduce the risk of many major age-related diseases. One of the main challenges in Geroscience has been linking our biological knowledge of the hallmarks of aging...

Research Terms

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Hongxin Dong

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$672,060

FY 2026

Project Title

Epigenetic Regulation in Aging and Alzheimer's Disease

Grant Number:

5R01AG079989-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by memory loss and neuropathological changes in the brain. Aging remains the single largest risk factor for sporadic AD, but the mechanisms underlying this risk are not well understood. Epigenetics has been i...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD dementia><AD model><AD neuropathogenesis><AD patients><AD risk><AD risk factor><AD therapy><AD treatment><APP-PS1><APP/PS1><Acceleration><Adult><Adult Human><Affect><Age><Age Months><Age Years><Aged 65 and Over><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimer's disease neuropathogenesis><Alzheimer's disease patient><Alzheimer's disease risk><Alzheimer's disease therapy><Alzheimer's neuropathogenesis><Alzheimer's patient><Alzheimer's therapy><Alzheimers Dementia><Ammon Horn><Amyloid><Amyloid Substance><Animal Model><Animal Models and Related Studies><Assay><Autopsy><Behavior><Bioassay><Biological Assay><Biological Markers><Body Tissues><Brain><Brain Nervous System><CNS plasticity><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CUT&RUN><Cas nuclease technology><ChIP assay><Cleavage Targets and Release Using Nuclease><Cleavage Under Targets and Release Using Nuclease><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cornu Ammonis><DNA Methylation><Degenerative Neurologic Disorders><Development><Diagnosis><Disease><Disorder><Dose><Drug Therapy><Dysfunction><Elderly><Elements><Encephalon><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Functional disorder><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Modified><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic><Genetic Transcription><Glutamate Receptor><HDAC2 histone deacetylase><Hippocampus><Histone Acetylation><Histones><Human><Life><Link><MS-275><Maps><Mediating><Memory><Memory Deficit><Memory Loss><Memory impairment><Mice><Mice Mammals><Modern Man><Molecular><Molecular Target><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Network Analysis><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuronal Plasticity><Neurons><Pathogenesis><Pathway Analysis><Pharmacological Treatment><Pharmacotherapy><Physiopathology><Play><Prefrontal Cortex><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Promoter Regions><Promotor Regions><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Research><Risk><Risk Factors><Role><Stimulus><Synaptic plasticity><Testing><Therapeutic><Tissues><Transcription><Transcriptional Regulator Homolog RPD3><Twin Studies><Wild Type Mouse><Work><above age 65><adulthood><advanced age><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged><aged 65 and greater><aged 65+><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aged ≥65><ages><aging associated><aging population><aging related><alzheimer model><alzheimer risk><bio-markers><biologic marker><biomarker><brain tissue><central nervous system plasticity><chromatin immunoprecipitation><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><drug action><drug intervention><drug treatment><epigenetic regulation><epigenetically><epigenome><gene modification><genetic approach><genetic promoter element><genetic promoter sequence><genetic strategy><genetically modified><genome scale><genome-wide><genomewide><geriatric><hippocampal><histone deacetylase 2><histone methylation><histone modification><human old age (65+)><improved><inhibitor><knock-down><knockdown><memory decline><memory dysfunction><model of animal><mouse model><murine model><natural aging><necropsy><neural plasticity><neurodegenerative illness><neuronal><neuropathologic><neuropathological><neuropathology><neuroplastic><neuroplasticity><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><normal aging><normative aging><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><over 65 years><overexpress><overexpression><pathophysiology><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><population aging><postmortem><prevent><preventing><primary degenerative dementia><pro-aging><progeronic><promote aging><promoter><promoter sequence><promotor><protein expression><response><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><senior citizen><social role><synapse function><synaptic function><tool><transcriptome sequencing><transcriptomic sequencing><treatment strategy><wildtype mouse><≥65 years>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sebastian Kadener

BRANDEIS UNIVERSITY, WALTHAM, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$662,618

FY 2026

Project Title

Uncovering the functions of circRNAs in aging

Grant Number:

5R01AG091918-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Aging can be described as the progressive loss of cellular homeostasis and an increase in dysfunction over time. One system that seems especially susceptible to the ravages of time is the central nervous system. Brain function requires multilevel control of gene expression. In partic...

Research Terms

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MICHAEL Thomas MARR

BRANDEIS UNIVERSITY, WALTHAM, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$662,618

FY 2026

Project Title

Uncovering the functions of circRNAs in aging

Grant Number:

5R01AG091918-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Aging can be described as the progressive loss of cellular homeostasis and an increase in dysfunction over time. One system that seems especially susceptible to the ravages of time is the central nervous system. Brain function requires multilevel control of gene expression. In partic...

Research Terms

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JEFF M HASTY

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$662,295

FY 2026

Project Title

Engineered genetic clocks for control of cellular aging

Grant Number:

5R01AG086348-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Synthetic biology offers transformative technologies for constructing or rewiring gene networks to create novel biological functions. However, the rational engineering of complex biological traits remains very challenging. To address this, we propose to integrate synthetic biology a...

Research Terms

<(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase><20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><5'-AMP-activated protein kinase><AMP-activated kinase><AMP-activated protein kinase><AMPK enzyme><Address><Adverse effects><Age><Aging><Artificial Genes><Autoregulation><Baker's Yeast><Biological><Biological Function><Biological Process><Brewer's Yeast><Budding Yeast><Caloric Intake><Cancers><Cell Aging><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Chemicals><Chromatin><Complex><Computer Models><Computerized Models><Coupling><Deacetylase><Degenerative Neurologic Disorders><Deterioration><Diagnostic><Disease><Disorder><Endomycetales><Energy Intake><Engineering><Equilibrium><Feedback><Ferroprotoporphyrin><Gene Transcription><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><HMG CoA reductase (NADPH) kinase><HMG CoA reductase kinase><HMG coenzyme A reductase (NADPH) kinase><Heme><Homeostasis><Increase lifespan><Job Location><Job Place><Job Setting><Job Site><L-Lysine><Lead><Length of Life><Life><Longevity><Lysine><Macropain><Macroxyproteinase><Malignant Neoplasms><Malignant Tumor><Mammalia><Mammals><Metabolic><Microfluidics><Microscopy><Mitochondria><Mitotic><Modeling><Molecular><Multicatalytic Proteinase><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Organism><Pattern><Pb element><Phenotype><Physiological Homeostasis><Prevention><Process><Production><Progenitor Cells><Property><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteome><Proteosome><Protoheme><RNA Expression><Recombinant DNA Technology><Replicative Senescence><Research><Route><S cerevisiae><S. cerevisiae><Saccharomyces cerevisiae><Saccharomycetales><Subcellular Process><Synthetic Genes><System><Technology><Testing><Time><Transcription><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcriptional Activator/Coactivator><Work><Work Location><Work Place><Work-Site><Workplace><Worksite><Yeasts><abnormal protein homeostasis><abnormal proteostasis><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age related pathways><age-related disease><age-related disorder><age-related impairment><ages><aging associated mechanism><aging delay><aging mechanism><aging pathway><aging process><aging related mechanism><aging related pathways><attenuate aging><balance><balance function><biologic><biological mechanism of age><biological pathways of age><boost longevity><caloric dietary content><cell age><cell engineering><cell type><cellular age><cellular engineering><cellular longevity><clinical applicability><clinical application><computational modeling><computational models><computer based models><computerized modeling><decelerate aging><defective proteostasis><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><delay age related><design><designing><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><ferroheme><foster longevity><gene network><genetically engineered><hallmarks of aging><heavy metal Pb><heavy metal lead><hydroxymethylglutaryl-CoA-reductase kinase><improve lifespan><improve longevity><inducible expression><inducible gene expression><insight><insoluble aggregate><life span><lifespan><lifespan extension><living system><malignancy><mechanism regulating aging><mechanisms involved in aging><metabolic rate><mitochondrial><model-based simulation><models and simulation><multicatalytic endopeptidase complex><natural aging><neoplasm/cancer><network architecture><neurodegenerative illness><normal aging><normative aging><novel><overexpress><overexpression><pathway involved in aging><pause aging><pillars of aging><postpone age related><prevent><preventing><prolong lifespan><prolong longevity><promote lifespan><promote longevity><protein aggregate><protein aggregation><protein homeostasis><protein homeostasis decline><protein homeostasis deficiency><protein homeostasis dysfunction><protein homeostasis failure><protein homeostasis loss><proteostasis><proteostasis decline><proteostasis defect><proteostasis deficiency><proteostasis dysfunction><proteostasis dysregulation><proteostasis failure><proteostasis impairment><proteostasis loss><replicative aging><retards aging><sensor><slow aging><slow down aging><slow the rate of aging><stem cells><success><support longevity><synthetic biology><trait><work setting><µfluidic>

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Nan Hao

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$662,295

FY 2026

Project Title

Engineered genetic clocks for control of cellular aging

Grant Number:

5R01AG086348-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Synthetic biology offers transformative technologies for constructing or rewiring gene networks to create novel biological functions. However, the rational engineering of complex biological traits remains very challenging. To address this, we propose to integrate synthetic biology a...

Research Terms

<(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase><20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><5'-AMP-activated protein kinase><AMP-activated kinase><AMP-activated protein kinase><AMPK enzyme><Address><Adverse effects><Age><Aging><Artificial Genes><Autoregulation><Baker's Yeast><Biological><Biological Function><Biological Process><Brewer's Yeast><Budding Yeast><Caloric Intake><Cancers><Cell Aging><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Chemicals><Chromatin><Complex><Computer Models><Computerized Models><Coupling><Deacetylase><Degenerative Neurologic Disorders><Deterioration><Diagnostic><Disease><Disorder><Endomycetales><Energy Intake><Engineering><Equilibrium><Feedback><Ferroprotoporphyrin><Gene Transcription><Genes><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Genetic Transcription><HMG CoA reductase (NADPH) kinase><HMG CoA reductase kinase><HMG coenzyme A reductase (NADPH) kinase><Heme><Homeostasis><Increase lifespan><Job Location><Job Place><Job Setting><Job Site><L-Lysine><Lead><Length of Life><Life><Longevity><Lysine><Macropain><Macroxyproteinase><Malignant Neoplasms><Malignant Tumor><Mammalia><Mammals><Metabolic><Microfluidics><Microscopy><Mitochondria><Mitotic><Modeling><Molecular><Multicatalytic Proteinase><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Organism><Pattern><Pb element><Phenotype><Physiological Homeostasis><Prevention><Process><Production><Progenitor Cells><Property><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteome><Proteosome><Protoheme><RNA Expression><Recombinant DNA Technology><Replicative Senescence><Research><Route><S cerevisiae><S. cerevisiae><Saccharomyces cerevisiae><Saccharomycetales><Subcellular Process><Synthetic Genes><System><Technology><Testing><Time><Transcription><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcriptional Activator/Coactivator><Work><Work Location><Work Place><Work-Site><Workplace><Worksite><Yeasts><abnormal protein homeostasis><abnormal proteostasis><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age related pathways><age-related disease><age-related disorder><age-related impairment><ages><aging associated mechanism><aging delay><aging mechanism><aging pathway><aging process><aging related mechanism><aging related pathways><attenuate aging><balance><balance function><biologic><biological mechanism of age><biological pathways of age><boost longevity><caloric dietary content><cell age><cell engineering><cell type><cellular age><cellular engineering><cellular longevity><clinical applicability><clinical application><computational modeling><computational models><computer based models><computerized modeling><decelerate aging><defective proteostasis><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><delay age related><design><designing><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><ferroheme><foster longevity><gene network><genetically engineered><hallmarks of aging><heavy metal Pb><heavy metal lead><hydroxymethylglutaryl-CoA-reductase kinase><improve lifespan><improve longevity><inducible expression><inducible gene expression><insight><insoluble aggregate><life span><lifespan><lifespan extension><living system><malignancy><mechanism regulating aging><mechanisms involved in aging><metabolic rate><mitochondrial><model-based simulation><models and simulation><multicatalytic endopeptidase complex><natural aging><neoplasm/cancer><network architecture><neurodegenerative illness><normal aging><normative aging><novel><overexpress><overexpression><pathway involved in aging><pause aging><pillars of aging><postpone age related><prevent><preventing><prolong lifespan><prolong longevity><promote lifespan><promote longevity><protein aggregate><protein aggregation><protein homeostasis><protein homeostasis decline><protein homeostasis deficiency><protein homeostasis dysfunction><protein homeostasis failure><protein homeostasis loss><proteostasis><proteostasis decline><proteostasis defect><proteostasis deficiency><proteostasis dysfunction><proteostasis dysregulation><proteostasis failure><proteostasis impairment><proteostasis loss><replicative aging><retards aging><sensor><slow aging><slow down aging><slow the rate of aging><stem cells><success><support longevity><synthetic biology><trait><work setting><µfluidic>

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Maria E. Bleil

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$651,175

FY 2026

Project Title

Women’s Health and Aging: Developmental Pathways Underlying Life Course Risk

Grant Number:

1R01AG098430-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

11/30/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The current application is responsive to the NIH-Wide Strategic Plan for Research on the Health of Women (2024-2028) led by the Office of Research on Women’s Health. It addresses Strategic Goal 1 (Research) under Objective 6 to advance women’s health through the study of key transiti...

Research Terms

<0-11 years old><21+ years old><Active Follow-up><Address><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Age><Aging><Archives><Assay><BMI><BMI percentile><BMI z-score><Bioassay><Biological><Biological Aging><Biological Assay><Birth><Blood><Blood Pressure><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Body Weight><Body mass index><Cardiometabolic Disease><Cardiometabolic Disorder><Cardiovascular Diseases><Child><Child Care><Child Rearing><Child Youth><Children (0-21)><D-Glucose><Data><Data Collection><Development><Dextrose><Disadvantaged><Disease><Disorder><Eating Disorders><Emotional><Ethnic Origin><Ethnicity><Exposure to><Family><Female><Female Health><Funding><Glucose><Goals><Health><Health behavior><Humulin R><Insulin><Insulin Resistance><Intervention><Intervention Strategies><Interview><Ketosis-Resistant Diabetes Mellitus><Knowledge><Life Cycle><Life Cycle Stages><Life Experience><Link><Literature><Maturity-Onset Diabetes Mellitus><Mediating><Mediator><Mental Depression><Mental Health><Mental Hygiene><Metabolic syndrome><Modeling><Muellerian inhibiting hormone><Mullerian-inhibiting factor><NICHD><NIDDM><NIH><National Institute of Child Health and Human Development><National Institutes of Health><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Novolin R><Obesity><Outcome><Ovarian aging><Parenting><Parenting behavior><Participant><Parturition><Pathway interactions><Physiologic><Physiological><Prepuberal state><Psychological Health><Puberty><Puericulture><Quetelet index><Race><Races><Regular Insulin><Research><Risk><Risk Factors><Role><Series><Slow-Onset Diabetes Mellitus><Socio-economic status><Socioeconomic Status><Stable Diabetes Mellitus><Staging><Strategic Planning><T2 DM><T2D><T2DM><Testing><Time><Transmission><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States National Institutes of Health><Visit><Weight Gain><Weight Increase><Woman><Women's Health><Work><accelerated aging><accelerated biological age><accelerated biological aging><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><active followup><adiposity><adult onset diabetes><adulthood><age acceleration><ages><aging biological marker><aging biomarker><aging human ovary><aging induced epigenetic change><aging marker><aging ovary><aging process><aging-associated epigenetic change><aging-related epigenetic change><anti-mullerian factor><anti-mullerian hormone><biologic><biological process of age><body weight gain><body weight increase><cardiometabolic><cardiometabolic risk><cardiometabolism><cardiovascular disorder><childrearing><cohort><corpulence><depression><developmental><disability><early life exposure><epigenetic aging><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic regulation of aging><experience><experiences among men><faster epigenetic aging><faster rates of epigenetic aging><follow up><follow-up><followed up><followup><girls><health related behavior><healthspan><healthy life span><improved><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><insulin resistant><insulin tolerance><ketosis resistant diabetes><kids><life course><male experience><maturity onset diabetes><men><men's experience><mid life><mid-life><middle age><middle aged><midlife><mortality><mullerian inhibiting substance><mullerian regression factor><mullerian-inhibiting hormone><mullerian-inhibitory substance><multimorbidity><multiple chronic conditions><obesity risk><ovarian senescence><ovulatory senescence><pandemic><pandemic disease><pathway><physical conditioning><physical health><prepubertal><prepuberty><prevent><preventing><prospective><protective factors><pubertal timing><racial><racial background><racial origin><rapid epigenetic aging><recruit><reproductive aging><reproductive cell senescence><reproductive senescence><response><risk for obesity><risk of obesity><social><social role><socio-economic position><socioeconomic position><standard measure><substance use><substance using><transmission process><type 2 DM><type II DM><type two diabetes><wt gain><youngster><♀>

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Louis Michael Messina

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$626,409

FY 2026

Project Title

Aging Impairs Wound Healing by an HSC-Autonomous Mechanism

Grant Number:

1R01AG092770-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract The world's population is aging rapidly, and by 2050, the population over 60 years will exceed 2 billion people or 25% of the total global population. Tissue repair is critical for the survival of all organisms. Aging causes a gradual decline in tissue integrity, partly due ...

Research Terms

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Carmen Giurgescu

UNIVERSITY OF CENTRAL FLORIDA, ORLANDO, FL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$620,718

FY 2026

Project Title

Epigenetic aging, social factors, and preterm birth among Black women

Grant Number:

5R01MD018293-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/18/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Preterm birth (PTB; <37 weeks gestation) is the leading cause of infant mortality among Black infants. Maternal chronological age has long been used to assess risk for PTB; however, chronological age assumes that individuals age at similar rates and does not capture the inter-individual differences ...

Research Terms

<37 weeks completed gestation><37 weeks gestation><Acceleration><Address><Age><Age Years><Aging><Area><BS-seq><Belief><Biological><Biological Aging><Biological Markers><Birth><Bisulfite-based sequencing><Black><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Caucasian Females><Caucasian Women><Cell Aging><Cell Senescence><Cellular Aging><Cellular Senescence><Chronic stress><Chronologic Fetal Maturity><Chronology><Coupled><Crime><DNA><DNA Methylation><Data><Deoxyribonucleic Acid><Disease><Disorder><Enrollment><Epigenetic age><Fetal Age><Genetic><Gestation><Gestational Age><Goals><GrimAge clock><Hannum clock><Horvath clock><Individual><Individual Differences><Infant><Infant Mortality><Infant Mortality Total><Length><Life Experience><Maternal Age><Measures><Medical Records><Methylation><Neighborhoods><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Participant><Parturition><Pattern><Performance><PhenoAge clocks><Precision Health><Pregnancy><Pregnant Women><Premature Birth><Prematurely delivering><Preterm Birth><Prevention><Publishing><Questionnaires><Race><Races><Replicative Senescence><Reporting><Research><Ribosomal DNA><Ribosomes><Risk><Risk Assessment><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Saliva><Sampling><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shapes><Term Birth><White Females><White Women><Whole Blood><Woman><Work><accelerated aging><accelerated biological age><accelerated biological aging><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><age acceleration><age associated><age at pregnancy><age correlated><age dependent><age linked><age related><age specific><ages><aging induced epigenetic change><aging-associated epigenetic change><aging-related epigenetic change><bio-markers><biologic><biologic marker><biological process of age><biomarker><bisulfite sequencing><bisulfite-seq><black female><black male><black man><black men><black women><case control><case-controlled><cohort><community level disadvantage><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><death among infants><death in first year of life><death in infancy><death in infants><design><designing><disadvantaged community><driving force><enroll><epigenetic age clocks><epigenetic aging><epigenetic clock><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic molecular clocks><epigenetic regulation of aging><expectant mother><expectant women><expecting mother><expecting women><experience><faster epigenetic aging><faster rates of epigenetic aging><full-term birth><full-term newborn><high risk><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><individuals who are pregnant><infant death><infant demise><infantile death><inter-individual variability><inter-individual variation><methylation clock><metropolitan><mortality in infants><neighborhood barrier><neighborhood disadvantage><neighborhood-level barrier><neighborhood-level disadvantage><novel><people who are pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><premature childbirth><premature delivery><preterm delivery><prevent><preventing><rDNA><racial><racial background><racial origin><rapid epigenetic aging><replicative aging><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social><social factors><social stresses><social stressor><systematic review><telomere><term newborn><therapeutic target><those who are pregnant><women who are pregnant><younger age>

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Joyce Ellen Ohm

UNIVERSITY OF CENTRAL FLORIDA, ORLANDO, FL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$620,718

FY 2026

Project Title

Epigenetic aging, social factors, and preterm birth among Black women

Grant Number:

5R01MD018293-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/18/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Preterm birth (PTB; <37 weeks gestation) is the leading cause of infant mortality among Black infants. Maternal chronological age has long been used to assess risk for PTB; however, chronological age assumes that individuals age at similar rates and does not capture the inter-individual differences ...

Research Terms

<37 weeks completed gestation><37 weeks gestation><Acceleration><Address><Age><Age Years><Aging><Area><BS-seq><Belief><Biological><Biological Aging><Biological Markers><Birth><Bisulfite-based sequencing><Black><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Caucasian Females><Caucasian Women><Cell Aging><Cell Senescence><Cellular Aging><Cellular Senescence><Chronic stress><Chronologic Fetal Maturity><Chronology><Coupled><Crime><DNA><DNA Methylation><Data><Deoxyribonucleic Acid><Disease><Disorder><Enrollment><Epigenetic age><Fetal Age><Genetic><Gestation><Gestational Age><Goals><GrimAge clock><Hannum clock><Horvath clock><Individual><Individual Differences><Infant><Infant Mortality><Infant Mortality Total><Length><Life Experience><Maternal Age><Measures><Medical Records><Methylation><Neighborhoods><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Participant><Parturition><Pattern><Performance><PhenoAge clocks><Precision Health><Pregnancy><Pregnant Women><Premature Birth><Prematurely delivering><Preterm Birth><Prevention><Publishing><Questionnaires><Race><Races><Replicative Senescence><Reporting><Research><Ribosomal DNA><Ribosomes><Risk><Risk Assessment><Risk Factors><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Saliva><Sampling><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Shapes><Term Birth><White Females><White Women><Whole Blood><Woman><Work><accelerated aging><accelerated biological age><accelerated biological aging><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><age acceleration><age associated><age at pregnancy><age correlated><age dependent><age linked><age related><age specific><ages><aging induced epigenetic change><aging-associated epigenetic change><aging-related epigenetic change><bio-markers><biologic><biologic marker><biological process of age><biomarker><bisulfite sequencing><bisulfite-seq><black female><black male><black man><black men><black women><case control><case-controlled><cohort><community level disadvantage><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><death among infants><death in first year of life><death in infancy><death in infants><design><designing><disadvantaged community><driving force><enroll><epigenetic age clocks><epigenetic aging><epigenetic clock><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic molecular clocks><epigenetic regulation of aging><expectant mother><expectant women><expecting mother><expecting women><experience><faster epigenetic aging><faster rates of epigenetic aging><full-term birth><full-term newborn><high risk><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><individuals who are pregnant><infant death><infant demise><infantile death><inter-individual variability><inter-individual variation><methylation clock><metropolitan><mortality in infants><neighborhood barrier><neighborhood disadvantage><neighborhood-level barrier><neighborhood-level disadvantage><novel><people who are pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><premature childbirth><premature delivery><preterm delivery><prevent><preventing><rDNA><racial><racial background><racial origin><rapid epigenetic aging><replicative aging><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><social><social factors><social stresses><social stressor><systematic review><telomere><term newborn><therapeutic target><those who are pregnant><women who are pregnant><younger age>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Rozalyn M. Anderson

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$618,580

FY 2026

Project Title

Molecular Networks in Aging and Caloric Restriction in Rhesus Monkeys

Grant Number:

5R01AG074503-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Age is the greatest risk factor for a host of chronic diseases, including cancer, diabetes, cardiovascular disease and neurodegeneration. The mechanistic basis for this shared risk and its continued increase as a function of age is not well understood. Caloric restriction (CR) without malnu...

Research Terms

<0-11 years old><21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Adipose tissue><Adult><Adult Human><Age><Age of Onset><Aged 65 and Over><Aging><Animals><Autopsy><Autoregulation><Biology of Aging><Blood Serum><Body Tissues><Caloric Restriction><Cancers><Cardiovascular Diseases><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Child><Child Youth><Children (0-21)><Chromatin><Chronic Disease><Chronic Illness><Clinical><Clinical Data><Computer Models><Computerized Models><Data><Diabetes Mellitus><Diet><Dietary Intervention><Disease><Disorder><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Fatty Tissue><Female><Fibroblasts><Gene Expression><Gene Transcription><Generalized Growth><Genetic Transcription><Growth><Hand><Health><Histology><Homeostasis><Human><Incidence><Increase lifespan><Inflammation><Inflammatory><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><Life><Link><Lipids><Liver><Logistic Regressions><Longitudinal Studies><Longitudinal Surveys><M mulatta><M. mulatta><Macaca mulatta><Macaca rhesus><Malignant Neoplasms><Malignant Tumor><Malnutrition><Mammalia><Mammals><Messenger RNA><Metabolic><Metabolic Processes><Metabolism><MicroRNAs><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Monkeys><Morbidity><Nerve Degeneration><Neuron Degeneration><Non-Polyadenylated RNA><Nutrition Interventions><Nutritional Deficiency><Nutritional Interventions><Outcome><PBMC><Pathology><Pathway interactions><Peripheral Blood Mononuclear Cell><Physical Function><Physiologic><Physiological><Physiological Homeostasis><Physiology><Population><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Primates><Primates Mammals><Probabilistic Models><Probability Models><Process><Protein Modification><Proteome><Proteomics><Publishing><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Randomized><Regulation><Research><Research Specimen><Resolution><Rhesus><Rhesus Macaque><Rhesus Monkey><Ribonucleic Acid><Risk Factors><Role><Sampling><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal Muscle><Specimen><Statistical Models><System><Techniques><Time><Tissue Growth><Tissues><Transcript><Transcription><Undernutrition><Voluntary Muscle><Whole Organism><Wisconsin><Work><Yeasts><above age 65><adipose><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age of 65 years onward><age related human disease><age-related disease><age-related disorder><age-related impairment><aged 65 and greater><aged 65+><aged ≥65><ages><aging associated><aging delay><aging related><attenuate aging><biological signal transduction><boost longevity><calorie restriction><cardiovascular disorder><chronic disorder><clinical applicability><clinical application><cohort><computational modeling><computational models><computer based models><computerized modeling><cytokine><decelerate aging><decline in function><decline in functional status><delay age related><density><design><designing><detection of nutrient><diabetes><diet intervention><dietary deficiency><dietary restriction><diets><elongating the lifespan><end of life><end-of-life><enhance healthspan><enhance longevity><epigenetically><extend healthspan><extend life span><extend lifespan><extend longevity><extending healthy lifespan><fat metabolism><foster longevity><functional decline><functional status decline><global gene expression><global transcription profile><hands><health record><healthspan extension><hepatic body system><hepatic organ system><human old age (65+)><improve healthspan><improve lifespan><improve longevity><improved><increase healthspan><indexing><insight><kids><lifespan extension><lipid metabolism><lipidomics><long-term study><longitudinal outcome studies><longitudinal research study><mRNA><male><malignancy><malnourished><metabolic imaging><metabolism measurement><metabolomics><metabonomics><miRNA><molecular profile><molecular signature><mortality><necropsy><neoplasm/cancer><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><non-human primate><nonhuman primate><novel><nutrient sensing><nutrition deficiency><nutrition deficiency disorder><nutritional deficiency disorder><ontogeny><over 65 years><pathway><pause aging><perception of nutrients><postmortem><postpone age related><programs><prolong healthspan><prolong lifespan><prolong longevity><promote healthspan><promote lifespan><promote longevity><random forest><randomisation><randomization><randomly assigned><recruit><resolutions><response><restricted diet><retards aging><risk sharing><slow aging><slow down aging><slow the rate of aging><social role><statistical linear mixed models><statistical linear models><support longevity><transcriptome><transcriptome sequencing><transcriptomic sequencing><translational model><white adipose tissue><yellow adipose tissue><youngster><≥65 years><♀><♂>

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Katrin I. Andreasson

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$615,747

FY 2026

Project Title

Metabolic mechanisms of cognitive decline in aging and AD mediated by inflammatory PGE2 signaling

Grant Number:

4R01AG080742-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Metabolic mechanisms of cognitive decline in aging and AD mediated by inflammatory PGE2 signaling Project Summary Aging is characterized by the development of maladaptive immune responses that promote cognitive decline and Alzheimer’s disease (AD). We recently identified the inflammatory lipid messe...

Research Terms

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GRAEME W DAVIS

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$615,633

FY 2026

Project Title

Homeostatic Neuroprotection in the Aging Nervous System

Grant Number:

5R01AG081252-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT In humans, an age-related decline in neuromuscular function is associated with loss of muscle mass (sarcopenia), increased frailty and a degradation of both health and quality of life. The only known treatments are life-style based, including exercise and diet. Rodent models have been used ...

Research Terms

<21+ years old><Adult><Adult Human><Adverse effects><Age><Aging><Anatomic Sites><Anatomic structures><Anatomy><Antibodies><Behavior><Biochemical><Cell Communication and Signaling><Cell Signaling><Cognitive><Collapsin><Collapsin-1><Collapsing Factor><DNA mutation><Data><Degenerative Neurologic Disorders><Development><Disease Progression><Drosophila><Drosophila genus><ENaC><Future><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Health><Human><In Situ><Injury><Integrins><Integrins Extracellular Matrix><Intracellular Communication and Signaling><Knock-out><Knockout><Life Style><Lifestyle><Maintenance><Mediating><Mice><Mice Mammals><Modern Man><Molecular><Motor><Mouse Strains><Murine><Mus><Muscle><Muscle Atrophy><Muscle Denervation><Muscle Tissue><Muscle denervation procedure><Muscle function><Muscular Atrophy><Mutation><Myoneural Junction><Nervous System><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic><Neurologic Body System><Neurologic Degenerative Conditions><Neurologic Disorders><Neurologic Organ System><Neurological><Neurological Disorders><Neuromuscular Junction><Onset of illness><Paper><Physiologic><Physiological><Publishing><QOL><Quality of life><Research><Risk Factors><Rodent Model><Role><Sem D><Sema3A><Semaphorin D><Semaphorin-3A><Semaphorins><Signal Transduction><Signal Transduction Systems><Signaling><Synapses><Synaptic><Testing><Therapeutic><accelerated aging><accelerated biological age><accelerated biological aging><adulthood><adverse consequence><adverse outcome><age acceleration><age associated><age associated alterations><age associated changes><age associated decline><age associated effects><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent decline><age effect><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related decline><age related effects><age specific><age specific alterations><age specific changes><aged><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging population><aging process><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><biological signal transduction><changes with age><combat><decline with age><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diet and exercise><disease onset><disorder onset><epithelial Na+ channel><epithelial sodium channel><frailty><fruit fly><genome mutation><impact of age><influence of age><injuries><life span><lifespan><mouse model><murine model><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle wasting><muscular><natural aging><neurodegenerative illness><neurological disease><neuromotor system><neuromuscular><neuromuscular function><neuromuscular system><neuroprotection><neuroprotective><neurotransmitter release><new marker><normal aging><normative aging><novel><novel biomarker><novel marker><pharmacologic><population aging><preservation><presynaptic><resilience><resilient><sarcopenia><sarcopenic><social role><synapse><synapse function><synaptic function><tool>

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Wei Wang

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$615,390

FY 2026

Project Title

Developing robust zero-shot AI models for anti-aging antibody design

Grant Number:

1R01AG098026-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Anti-aging antibody research, including strategies targeting interleukins and other antigens, shows promise in rejuvenating the immune system, improving metabolic functions, and extending healthy lifespans. AI-driven platforms are revolutionizing antibody development by accelerating ...

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Anna Tarakanova

UNIVERSITY OF CONNECTICUT STORRS, STORRS-MANSFIELD, CT

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$607,755

FY 2026

Project Title

Multiscale Effects of Aging on Elastic Arterial Tissue Mechanics

Grant Number:

5R01AG084715-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Elastin evolved in vertebrates to support a closed, pulsatile circulatory system, and was subsequently co-opted to support reversible extension in a variety of organs, such as the lungs, viscera, and skin. It has remarkable elastic properties supporting recoil following large strains...

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Ying Ann Chiao

OKLAHOMA MEDICAL RESEARCH FOUNDATION, OKLAHOMA CITY, OK

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$598,185

FY 2026

Project Title

Mitochondrial NAD+ Metabolism in Cardiac Aging

Grant Number:

5R01AG081855-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Nicotinamide adenine dinucleotide (NAD+) is a redox cofactor for energy metabolism and a co-substrate of sirtuins for protein deacetylation. Cellular NAD+ levels decline with age in the heart and other organs. Previous studies have shown that cellular NAD+ repletion or boost...

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Daniel Trott

UNIVERSITY OF TEXAS ARLINGTON, ARLINGTON, TX

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$569,832

FY 2026

Project Title

Mechanisms of CD8+ mediated cell non-autonomous arterial aging

Grant Number:

5R01AG086447-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY: Aging is the most predictive risk factor for cardiovascular disease. Aged arteries exhibit increased large artery stiffness and blunted endothelium dependent dilation; both of these changes occur prior to the onset of overt cardiovascular disease, such as atherosclerosis or stroke. ...

Research Terms

<21+ years old><ASCVD><Address><Adoptive Transfer><Adult><Adult Human><Age><Aging><Antibodies><Aorta><Apoplexy><Arteries><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Bioavailability><Biological Availability><Biomechanics><Blood Plasma><Blood Vessels><Body Tissues><Brain Vascular Accident><C-C CKR-5><C-C CKR-5 Gene><C-C Chemokine Receptor Type 5><C-C Chemokine Receptor Type 5 Gene><CC Chemokine Receptor 5><CC-CKR-5><CC-CKR-5 Gene><CC-CKR5><CCCKR5><CCCKR5 Gene><CCL5><CCR-5><CCR-5 Gene><CCR5><CCR5 Protein><CCR5 Receptors><CCR5 gene><CD195 Antigen><CD195 Antigen Gene><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><CHEMR13><CHEMR13 Gene><CKR-5><CKR-5 Gene><CKR5><CKR5 Gene><CKR5 Receptors><CMKBR5><CMKBR5 Gene><Cardiovascular Diseases><Cell Aging><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Count><Cell Culture Techniques><Cell Interaction><Cell Number><Cell Senescence><Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Aging><Cellular Senescence><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chemokine (C-C Motif) Ligand 5><Chemokine (C-C Motif) Receptor 5><Chemokine (C-C) Receptor 5><Chemokine (C-C) Receptor 5 Gene><Chemotactic Cytokines><Clinical><Co-culture><Cocultivation><Coculture><Coculture Techniques><Collagen><D17S136E><Data><Deposit><Deposition><Development><Dysfunction><Elderly><Endogenous Nitrate Vasodilator><Endothelial Cells><Endothelium><Endothelium-Derived Nitric Oxide><Exhibits><Fibroblasts><Fibrosis><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional disorder><General Transcription Factor Gene><General Transcription Factors><Genetic><HIV-1 Fusion Co-Receptor><HIV-1 Fusion Co-Receptor Gene><Health><Histology><Homologous Chemotactic Cytokines><Human><Immune><Immune system><Immunes><Immunology><Impairment><Inflammation><Inflammatory><Intercrines><Intervention><Intracellular Communication and Signaling><Involuntary Muscle><Knock-out><Knockout><LYT3><Lead><MGC17164><Mechanics><Mediating><Memory><Mesenteric><Mesenteric Arteries><Mesentery><Methods><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Mononitrogen Monoxide><Murine><Mus><NGS Method><NGS system><Nitric Oxide><Nitrogen Monoxide><Nitrogen Protoxide><Outcome Assessment><Pb element><Phenotype><Physiologic Availability><Physiologic pulse><Physiology><Physiopathology><Plasma><Plasma Serum><Play><Predicting Risk><Production><Proteins><Pulse><RANTES><Receptor Protein><Replicative Senescence><Reticuloendothelial System, Serum, Plasma><Rodent Model><Role><SCYA5><SIS cytokines><SIS delta><SIS-delta><SISd><Series><Signal Transduction><Signal Transduction Systems><Signaling><Smooth Muscle><Stroke><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cell RANTES Protein><T-Cell Specific Protein p288><T-Cells><T-Lymphocyte><T-cell therapeutics><T-cell transfer therapy><T8 Cells><T8 Lymphocytes><TCP228><Techniques><Testing><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Wild Type Mouse><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><adulthood><advanced age><age associated><age correlated><age dependent><age linked><age related><age specific><aged><aged mice><aged mouse><ages><aging process><antagonism><antagonist><arterial stiffening><arterial stiffness><artery stiffening><artery stiffness><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><biological signal transduction><biomechanical><brachial artery><brain attack><cardiovascular disorder><cardiovascular risk><cardiovascular risk factor><cell culture><cell cultures><cell type><cerebral vascular accident><cerebrovascular accident><chemoattractant cytokine><chemokine><cytokine><developmental><driving><elderly mice><endothelial cell derived relaxing factor><endothelial dysfunction><experiment><experimental research><experimental study><experiments><flow cytophotometry><forecasting risk><geriatric><heavy metal Pb><heavy metal lead><in vivo><insight><mechanic><mechanical><mouse model><murine model><next gen sequencing><next generation sequencing><nextgen sequencing><novel><old mice><older adult><older adulthood><pathophysiology><pharmacologic><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><preservation><receptor><recruit><replicative aging><risk prediction><risk predictions><scRNA sequencing><scRNA-seq><senior citizen><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stroked><strokes><therapeutic T-cell platform><thymus derived lymphocyte><trafficking><transcription factor><transcriptomics><translational opportunities><translational potential><translational study><vascular><wildtype mouse>

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Giuseppe Coppotelli

UNIVERSITY OF RHODE ISLAND, KINGSTON, RI

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$567,224

FY 2026

Project Title

Tissue-Specific Modulation of mtDNA Mutations: Exploring Aging and Lifestyle Interventions

Grant Number:

1R01AG092603-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Mitochondrial dysfunction (MD) resulting from mtDNA mutations has been implicated in a broad spectrum of human pathologies, including mitochondrial diseases, neurodegenerative disorders, metabolic syndromes, cancer and cardiovascular diseases. In addition, mtDNA mutations by contributing to ...

Research Terms

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Jaime Marie Ross

UNIVERSITY OF RHODE ISLAND, KINGSTON, RI

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$567,224

FY 2026

Project Title

Tissue-Specific Modulation of mtDNA Mutations: Exploring Aging and Lifestyle Interventions

Grant Number:

1R01AG092603-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Mitochondrial dysfunction (MD) resulting from mtDNA mutations has been implicated in a broad spectrum of human pathologies, including mitochondrial diseases, neurodegenerative disorders, metabolic syndromes, cancer and cardiovascular diseases. In addition, mtDNA mutations by contributing to ...

Research Terms

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Adina F Turcu

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$564,488

FY 2026

Project Title

11-Oxyandrogens and Aging: Health Implications

Grant Number:

5R01AG080516-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT The adrenal androgen precursors dehydroepiandrosterone (DHEA) and its sulfate (DHEAS) are known to contribute to fetal development and adrenarche. The role of adrenal androgens following puberty and throughout adulthood has been poorly understood. The adrenal glands are also the source of ...

Research Terms

<11-ketotestosterone><11-oxotestosterone><21+ years old><4-Androstene-3,17-dione><5 alpha-Dihydrotestosterone><5-alpha-DHT><ARO><ARO1><Address><Adrenal Glands><Adrenals><Adult><Adult Human><Age><Aging><Androgenic Agents><Androgenic Compounds><Androgens><Androst-4-ene-3,17-dione><Androstanolone><Androstenedione><Androstenolone><Aromatase><Binding><Bioavailability><Biological><Biological Availability><Biological Markers><Blood Serum><CPV1><CYAR><CYP 19><CYP19><CYP19A1><CYP19A1 gene><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular Pathology><Cardiovascular system><Clinical><Cognitive><Congenital adrenal hyperplasia><Cross-Sectional Studies><Cross-Sectional Survey><Cytochrome P-450 CYP19><Cytochrome P450 19><Cytochrome P450 19A1><DHEA><Data><Data Set><Dehydroisoandrosterone><Developing fetus><Development><Dihydrotestosterone><Disease><Disease Frequency Surveys><Disorder><Dysfunction><Elderly><Eligibility><Eligibility Determination><Estrogen Synthase><Estrogen Synthetase><Estrogens><Fats><Fatty acid glycerol esters><Fetal Development><Fracture><Functional disorder><Goals><Gonadal Steroid Hormones><Gonadal structure><Hct><Health><Heart><Heart Vascular><Hematocrit><Hematocrit procedure><Hemoglobin><History><Human><Image Analyses><Image Analysis><Individual><Knowledge><Laboratories><Long-term cohort><Long-term trends><Longer-term trends><Longitudinal cohort><Longitudinal trends><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measurement><Measures><Menopause><Metabolic><Modern Man><Molecular Interaction><Outcome><P-450AROM><P450AROM><Packed Erythrocyte Volume><Packed Red-Cell Volume><Participant><Pathology><Pattern><Perimenopausal><Perimenopause><Personal Satisfaction><Phenotype><Physiologic><Physiologic Availability><Physiological><Physiology><Physiopathology><Play><Post-Menopause><Post-menopausal Period><Postmenopausal Period><Postmenopause><Prasterone><Pre-Menopause><Pre-menopausal Period><Premenopausal><Premenopausal Period><Premenopause><Production><Protocol Screening><Puberty><Public Health><Recording of previous events><Research><Role><SHBG><SHBG gene><Sampling><Serum><Sex Hormone-Binding Globulin Gene><Sex Hormones><Sex Steroid Hormones><Sexual Health><Site><Source><Stanolone><Steroid Compound><Steroids><Sulfate><Survey Instrument><Surveys><Temporal trend><Testing><Testosterone><Therapeutic Androgen><Therapeutic Androstanolone><Therapeutic Androstenedione><Therapeutic Dehydroepiandrosterone><Therapeutic Estrogen><Therapeutic Testosterone><Time><Time trend><Trans-Testosterone><Trends over time><Visit><Woman><Women's study><Work><adulthood><advanced age><after menopause><age associated><age correlated><age dependent><age linked><age related><age specific><ages><aging associated><aging related><androgen excess><androgen independent prostate cancer><androgen indifferent prostate cancer><androgen insensitive prostate cancer><androgen resistance in prostate cancer><androgen resistant prostate cancer><androgenic><bio-markers><biologic><biologic marker><biomarker><bone><bone fracture><bone health><bone loss><cardiometabolic risk><cardiovascular health><castration resistant CaP><castration resistant PCa><castration resistant prostate cancer><childbearing age><circulatory system><co-morbid><co-morbidity><cohort><comorbidity><cross-sectional research study><declines in circulating testosterone><declining testosterone><decreased levels of testosterone><decreases in testosterone><decreasing testosterone><deficiency in testosterone><dehydroepiandrosterone><delta-4-Androstenedione><design><designing><developmental><diminished testosterone><epidemiology research study><epidemiology study><epidemiology survey><female study><fertile age><fetal><following menopause><geriatric><gonad><gonad function><gonadal function><gonadal steroids><gonads><histories><hormone refractory prostate cancer><image evaluation><image interpretation><intraperitoneal><low circulating testosterone><low levels of testosterone><lower testosterone><men><menopause transition><multi-ethnic><multi-racial><multiethnic><multiracial><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><past menopause><pathophysiology><peri-menopausal><peri-menopause><post-menopausal><postmenopausal><postmenopausal status><pre-menopausal><premature adrenarche><premenopausal status><prostate cancer resistant to androgen><reduced testosterone><reduction in testosterone><reproductive><reproductive age><reproductive years><senior citizen><sex><sex steroid><social role><study among females><study among women><study in females><study in women><study on females><study on women><study within women><suprarenal gland><testosterone decline><testosterone deficiency><testosterone insufficiency><testosterone loss><transition to menopause><transitional menopause><trend><well-being><wellbeing>

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David W Walker

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$554,549

FY 2026

Project Title

Role of Mitochondrial Homeostasis in Animal Aging

Grant Number:

5R01AG037514-14

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2010

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary As advanced age is the most significant risk factor for Alzheimer’s disease (AD), targeting detrimental age-related processes may lead to effective therapies. Mitochondrial dysfunction and pro-inflammatory signaling are each thought to be key drivers of aging and AD. However, a clear...

Research Terms

<21+ years old><AD and related dementia><AD brain><AD dementia><AD model><AD pathology><AD patients><AD related dementia><AD risk><AD risk factor><ADRD><Acids><Adult><Adult Human><Age of Onset><Aging><Agonist><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's brain><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimer's pathology><Alzheimer's patient><Alzheimers Dementia><Animals><Autophagocytosis><Autoregulation><BCL2-Interacting Protein><Binding Proteins><Biological><Body System><Body Tissues><Brain><Brain Nervous System><Cell Communication and Signaling><Cell Signaling><Cell model><Cellular model><Cytosol><DNA><DNA Nucleases><DNase><DP5><Deoxyribonucleases><Deoxyribonucleic Acid><Development><Drosophila><Drosophila genus><Elderly><Encephalon><Flies><Genetic><Goals><HRK gene><Harakiri><Health><Homeostasis><Immune Cell Activation><Immune signaling><Immune system><Immunoglobulin Enhancer-Binding Protein><Increase lifespan><Inflammation><Inflammatory><Inflammatory Response><Innate Immune Response><Innate Immune System><Intracellular Communication and Signaling><Knowledge><Ligand Binding Protein><Ligand Binding Protein Gene><Link><Lysosomes><Mammalia><Mammals><Mediating><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Mitochondria><Mitochondrial DNA><Molecular><NF-kB><NF-kappa B><NF-kappaB><NFKB><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neurocyte><Neurologic Body System><Neurologic Organ System><Neurons><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Onset of illness><Organ System><Outer Mitochondrial Membrane><Pathogen detection><Pathogenesis><Pathology><Physiological Homeostasis><Prevalence><Primary Senile Degenerative Dementia><Process><Protein Binding><Reporting><Research><Research Design><Respiratory Chain><Risk Factors><Role><Signal Transduction><Signal Transduction Systems><Signaling><Stress><Study Type><Surface Proteins><System><Therapeutic Intervention><Tissues><Transcription Factor NF-kB><Upregulation><Work><adulthood><advanced age><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age related pathways><age reversal><age specific><age-related disease><age-related disorder><age-related impairment><aged><aged brain><aging associated><aging associated mechanism><aging brain><aging mechanism><aging pathway><aging related><aging related mechanism><aging related pathways><aging reversal><alleviate age related><alleviate aging><alzheimer model><alzheimer risk><ameliorating aging><autophagy><biologic><biological mechanism of age><biological pathways of age><biological signal transduction><boost longevity><bound protein><counter age related><counter aging><counteract age related><counteract aging><developmental><disease onset><disorder onset><drivers of aging><effective therapy><effective treatment><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><fly><foster longevity><fruit fly><genetic approach><genetic strategy><geriatric><gerodriver><hallmarks of aging><healthspan><healthy life span><immune activation><improve lifespan><improve longevity><intervention therapy><kappa B Enhancer Binding Protein><lifespan extension><mechanism regulating aging><mechanisms involved in aging><mitochondrial><mitochondrial autophagy><mitochondrial dysfunction><mtDNA><neural inflammation><neuroinflammation><neuroinflammatory><neuronal><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapeutics><new therapy><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><next generation therapeutics><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapeutics><novel therapy><novel therapy approach><novel therapy target><nuclear factor kappa beta><pathway involved in aging><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><pillars of aging><prevent><preventing><primary degenerative dementia><prolong lifespan><prolong longevity><promote lifespan><promote longevity><reverse age><reverse aging><reverse aging effects><reversible aging><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><senior citizen><sensor><social role><study design><support longevity><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ryo Higuchi-Sanabria

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$544,397

FY 2026

Project Title

When actin's not actin like actin: Nuclear actin impacts transcription and aging

Grant Number:

5R01AG079806-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The functional significance of actin in cellular health and fitness is unquestionable, as the actin cytoskeleton is required for a diverse array of cellular processes as simple as movement and motility. The loss of function of actin is seen in clinical manifestations in many disease...

Research Terms

View Full Project Details on NIH Reporter

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Jodi A. Flaws

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$533,785

FY 2026

Project Title

Phthalate Exposure and Female Reproductive Aging

Grant Number:

5R01ES034112-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

10/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The female reproductive system ages before any other physiological system, making it the most sensitive indicator of aging. Most women experience reproductive senescence around age 51, but many women experience early reproductive aging (early menopause). This is a serious public health problem becau...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><21+ years old><3-10C><AH Receptors><AMCF-I><Acceleration><Acute><Adhesives><Adult><Adult Human><Age><Aging><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Aryl Hydrocarbon Receptor><Assay><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cells><B-Lymphocytes><B-cell><BCDF><BSF-2><BSF2><Binding><Bioassay><Biological Assay><Blood Serum><Body Tissues><CCL5><CD11b><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CR3A><CSIF><CSIF-10><CXCL8><Cannot achieve a pregnancy><Cell Aging><Cell Body><Cell Count><Cell Number><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Cessation of life><Characteristics><Chemokine (C-C Motif) Ligand 5><Childbirth><Chronic><Curcumin><Cytokine Synthesis Inhibitory Factor><Cytotoxic cell><D17S136E><Data><Death><Defoaming Agents><Delayed Childbearing><Development><Diferuloylmethane><Difficulty conceiving><Dioxin Receptors><Disadvantaged><Disease><Disorder><Dose><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine Gland Secretion><Endocrine disrupting agent><Environment><Exposure to><Fecundability><Fecundity><Female><Female Genital System><Female Health><Fertility><Fibrosis><Follicle Stimulating Hormone><Follitropin><Foundations><GCP1><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Greater sac of peritoneum><Growth><HPGF><Health><Hepatocyte-Stimulating Factor><Hormones><Hybridoma Growth Factor><Hypophysis><Hypophysis Cerebri><Hypothalamic structure><Hypothalamus><IFN><IFN-beta 2><IFNB2><IL-10><IL-6><IL-8><IL10><IL10A><IL6 Protein><IL8><IL8 gene><ITGAM><ITGAM gene><Immune><Immunes><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Infertility><Inflammasome><Inflammation><Inflammatory><Interferons><Interleukin 10 Precursor><Interleukin-10><Interleukin-6><K lymphocyte><K60><KISS1><KISS1 Metastasis Suppressor><KISS1 gene><KiSS-1><Lubricants><MAC1A><MEHP><MGC17164><MGC39258><MGI-2><MO1A><Macrophage><Medical Device><Menopausal Symptom><Mental Depression><Metastin><Mice><Mice Mammals><Molecular Interaction><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><NK Cells><Natural Killer Cells><Nuclear Translocator><Osteoporosis><Ovarian Follicle><Ovary><Pathway interactions><Peritoneal Cavity><Peritoneal Macrophages><Pesticides><Physiologic><Physiological><Pituitary><Pituitary Gland><Pituitary Nervous System><Plasmacytoma Growth Factor><Play><Polyaromatic Hydrocarbon Receptors><Population><Premature Menopause><Proliferating><Public Health><Publishing><RANTES><Replicative Senescence><Reporter><Reproduction><Reproductive Health><Risk><Role><SCYA5><SCYB8><SIS delta><SIS-delta><SISd><Serum><Signal Pathway><Solvents><System><T-Cell RANTES Protein><T-Cell Specific Protein p288><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><TCDD Receptors><TCP228><TSG-1><Testing><Therapeutic Hormone><Time><Tissue Growth><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Turmeric Yellow><Uterus><Woman><Women's Health><Wood><Wood material><Work><adulthood><ages><analyze gene expression><angiogenesis><antagonism><antagonist><b-ENAP><cardiovascular disease risk><cardiovascular disorder risk><child birth><consumer product><cytokine><decreased ovarian reserve><depression><developmental><diminished ovarian reserve><early experience><early menopause><early onset><endocrine disrupting compound><environmental chemical><epidemiology research study><epidemiology study><epidemiology survey><experience><exposed human population><female reproductive body system><female reproductive organ system><female reproductive system><fertility cessation><fertility loss><gene expression analysis><gene expression assay><gynecologic body system><gynecologic organ system><human exposure><human tissue><hypothalamic><improved><infertile><inhibin B><interferon beta 2><kisspeptin><men><mono-(2-ethylhexyl)phthalate><novel><ontogeny><ovarian follicular pool><pathway><personal care products><phthalates><premature age of menopause><primary infertility><protein expression><replicative aging><reproductive><reproductive aging><reproductive cell senescence><reproductive longevity><reproductive senescence><social role><subfertility><thymus derived lymphocyte><transcriptional profiling><womb><♀>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Romana A. Nowak

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$533,785

FY 2026

Project Title

Phthalate Exposure and Female Reproductive Aging

Grant Number:

5R01ES034112-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

10/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The female reproductive system ages before any other physiological system, making it the most sensitive indicator of aging. Most women experience reproductive senescence around age 51, but many women experience early reproductive aging (early menopause). This is a serious public health problem becau...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><21+ years old><3-10C><AH Receptors><AMCF-I><Acceleration><Acute><Adhesives><Adult><Adult Human><Age><Aging><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Aryl Hydrocarbon Receptor><Assay><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cells><B-Lymphocytes><B-cell><BCDF><BSF-2><BSF2><Binding><Bioassay><Biological Assay><Blood Serum><Body Tissues><CCL5><CD11b><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CR3A><CSIF><CSIF-10><CXCL8><Cannot achieve a pregnancy><Cell Aging><Cell Body><Cell Count><Cell Number><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Cessation of life><Characteristics><Chemokine (C-C Motif) Ligand 5><Childbirth><Chronic><Curcumin><Cytokine Synthesis Inhibitory Factor><Cytotoxic cell><D17S136E><Data><Death><Defoaming Agents><Delayed Childbearing><Development><Diferuloylmethane><Difficulty conceiving><Dioxin Receptors><Disadvantaged><Disease><Disorder><Dose><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine Gland Secretion><Endocrine disrupting agent><Environment><Exposure to><Fecundability><Fecundity><Female><Female Genital System><Female Health><Fertility><Fibrosis><Follicle Stimulating Hormone><Follitropin><Foundations><GCP1><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Greater sac of peritoneum><Growth><HPGF><Health><Hepatocyte-Stimulating Factor><Hormones><Hybridoma Growth Factor><Hypophysis><Hypophysis Cerebri><Hypothalamic structure><Hypothalamus><IFN><IFN-beta 2><IFNB2><IL-10><IL-6><IL-8><IL10><IL10A><IL6 Protein><IL8><IL8 gene><ITGAM><ITGAM gene><Immune><Immunes><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Infertility><Inflammasome><Inflammation><Inflammatory><Interferons><Interleukin 10 Precursor><Interleukin-10><Interleukin-6><K lymphocyte><K60><KISS1><KISS1 Metastasis Suppressor><KISS1 gene><KiSS-1><Lubricants><MAC1A><MEHP><MGC17164><MGC39258><MGI-2><MO1A><Macrophage><Medical Device><Menopausal Symptom><Mental Depression><Metastin><Mice><Mice Mammals><Molecular Interaction><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><NK Cells><Natural Killer Cells><Nuclear Translocator><Osteoporosis><Ovarian Follicle><Ovary><Pathway interactions><Peritoneal Cavity><Peritoneal Macrophages><Pesticides><Physiologic><Physiological><Pituitary><Pituitary Gland><Pituitary Nervous System><Plasmacytoma Growth Factor><Play><Polyaromatic Hydrocarbon Receptors><Population><Premature Menopause><Proliferating><Public Health><Publishing><RANTES><Replicative Senescence><Reporter><Reproduction><Reproductive Health><Risk><Role><SCYA5><SCYB8><SIS delta><SIS-delta><SISd><Serum><Signal Pathway><Solvents><System><T-Cell RANTES Protein><T-Cell Specific Protein p288><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><TCDD Receptors><TCP228><TSG-1><Testing><Therapeutic Hormone><Time><Tissue Growth><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Turmeric Yellow><Uterus><Woman><Women's Health><Wood><Wood material><Work><adulthood><ages><analyze gene expression><angiogenesis><antagonism><antagonist><b-ENAP><cardiovascular disease risk><cardiovascular disorder risk><child birth><consumer product><cytokine><decreased ovarian reserve><depression><developmental><diminished ovarian reserve><early experience><early menopause><early onset><endocrine disrupting compound><environmental chemical><epidemiology research study><epidemiology study><epidemiology survey><experience><exposed human population><female reproductive body system><female reproductive organ system><female reproductive system><fertility cessation><fertility loss><gene expression analysis><gene expression assay><gynecologic body system><gynecologic organ system><human exposure><human tissue><hypothalamic><improved><infertile><inhibin B><interferon beta 2><kisspeptin><men><mono-(2-ethylhexyl)phthalate><novel><ontogeny><ovarian follicular pool><pathway><personal care products><phthalates><premature age of menopause><primary infertility><protein expression><replicative aging><reproductive><reproductive aging><reproductive cell senescence><reproductive longevity><reproductive senescence><social role><subfertility><thymus derived lymphocyte><transcriptional profiling><womb><♀>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

LORI T RAETZMAN

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$533,785

FY 2026

Project Title

Phthalate Exposure and Female Reproductive Aging

Grant Number:

5R01ES034112-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

10/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

The female reproductive system ages before any other physiological system, making it the most sensitive indicator of aging. Most women experience reproductive senescence around age 51, but many women experience early reproductive aging (early menopause). This is a serious public health problem becau...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><21+ years old><3-10C><AH Receptors><AMCF-I><Acceleration><Acute><Adhesives><Adult><Adult Human><Age><Aging><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Aryl Hydrocarbon Receptor><Assay><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cells><B-Lymphocytes><B-cell><BCDF><BSF-2><BSF2><Binding><Bioassay><Biological Assay><Blood Serum><Body Tissues><CCL5><CD11b><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CR3A><CSIF><CSIF-10><CXCL8><Cannot achieve a pregnancy><Cell Aging><Cell Body><Cell Count><Cell Number><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Cessation of life><Characteristics><Chemokine (C-C Motif) Ligand 5><Childbirth><Chronic><Curcumin><Cytokine Synthesis Inhibitory Factor><Cytotoxic cell><D17S136E><Data><Death><Defoaming Agents><Delayed Childbearing><Development><Diferuloylmethane><Difficulty conceiving><Dioxin Receptors><Disadvantaged><Disease><Disorder><Dose><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine Gland Secretion><Endocrine disrupting agent><Environment><Exposure to><Fecundability><Fecundity><Female><Female Genital System><Female Health><Fertility><Fibrosis><Follicle Stimulating Hormone><Follitropin><Foundations><GCP1><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Greater sac of peritoneum><Growth><HPGF><Health><Hepatocyte-Stimulating Factor><Hormones><Hybridoma Growth Factor><Hypophysis><Hypophysis Cerebri><Hypothalamic structure><Hypothalamus><IFN><IFN-beta 2><IFNB2><IL-10><IL-6><IL-8><IL10><IL10A><IL6 Protein><IL8><IL8 gene><ITGAM><ITGAM gene><Immune><Immunes><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Infertility><Inflammasome><Inflammation><Inflammatory><Interferons><Interleukin 10 Precursor><Interleukin-10><Interleukin-6><K lymphocyte><K60><KISS1><KISS1 Metastasis Suppressor><KISS1 gene><KiSS-1><Lubricants><MAC1A><MEHP><MGC17164><MGC39258><MGI-2><MO1A><Macrophage><Medical Device><Menopausal Symptom><Mental Depression><Metastin><Mice><Mice Mammals><Molecular Interaction><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><NK Cells><Natural Killer Cells><Nuclear Translocator><Osteoporosis><Ovarian Follicle><Ovary><Pathway interactions><Peritoneal Cavity><Peritoneal Macrophages><Pesticides><Physiologic><Physiological><Pituitary><Pituitary Gland><Pituitary Nervous System><Plasmacytoma Growth Factor><Play><Polyaromatic Hydrocarbon Receptors><Population><Premature Menopause><Proliferating><Public Health><Publishing><RANTES><Replicative Senescence><Reporter><Reproduction><Reproductive Health><Risk><Role><SCYA5><SCYB8><SIS delta><SIS-delta><SISd><Serum><Signal Pathway><Solvents><System><T-Cell RANTES Protein><T-Cell Specific Protein p288><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><TCDD Receptors><TCP228><TSG-1><Testing><Therapeutic Hormone><Time><Tissue Growth><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Turmeric Yellow><Uterus><Woman><Women's Health><Wood><Wood material><Work><adulthood><ages><analyze gene expression><angiogenesis><antagonism><antagonist><b-ENAP><cardiovascular disease risk><cardiovascular disorder risk><child birth><consumer product><cytokine><decreased ovarian reserve><depression><developmental><diminished ovarian reserve><early experience><early menopause><early onset><endocrine disrupting compound><environmental chemical><epidemiology research study><epidemiology study><epidemiology survey><experience><exposed human population><female reproductive body system><female reproductive organ system><female reproductive system><fertility cessation><fertility loss><gene expression analysis><gene expression assay><gynecologic body system><gynecologic organ system><human exposure><human tissue><hypothalamic><improved><infertile><inhibin B><interferon beta 2><kisspeptin><men><mono-(2-ethylhexyl)phthalate><novel><ontogeny><ovarian follicular pool><pathway><personal care products><phthalates><premature age of menopause><primary infertility><protein expression><replicative aging><reproductive><reproductive aging><reproductive cell senescence><reproductive longevity><reproductive senescence><social role><subfertility><thymus derived lymphocyte><transcriptional profiling><womb><♀>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

David G Harrison

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$509,817

FY 2026

Project Title

Common Inflammation Pathways between Aging and Hypertension That Weaken Bone

Grant Number:

5R01AG076785-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary / Abstract Osteoporosis is under diagnosed and under treated. It is essential that we develop novel tools for early detection and treatment strategies to reduce the number of fragility fractures that accompany aging. Systemic hypertension is another disease of aging that commonly co-...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Age><Age-Related Bone Loss><Aging><American Heart Association><Animals><Antibodies><Assay><BP reduction><Bioassay><Biological Assay><Biology><Blood Pressure><Blood Pressure Monitors><Blood monocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Resorption><Bone remodeling><CRE Recombinase><CSF-1><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cells><Cessation of life><Clinical Pharmacology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Collaborations><Colony-Stimulating Factor 1><Communication><Continuous Sphygmomanometers><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><DREADDs><Data><Death><Dendritic Cells><Denervation><Deterioration><Diagnosis><Disease><Disorder><Early Diagnosis><Early treatment><Economic Burden><Endothelial Cells><Endothelium><Enterobacteria phage P1 Cre recombinase><Estrogens><Exposure to><Fracture><Genes><Goals><Health><Hematopoietic><Hip Fractures><Human><Hypertension><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immune><Immune Cell Activation><Immunes><Individual><Inflammation><Inflammatory><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Interleukins><Intracellular Communication and Signaling><M-CSF><Macrophage><Macrophage Colony-Stimulating Factor><Marrow monocyte><Measurement><Mechanical Stimulation><Mechanics><Mediating><Mediator><Menopause><Methodology><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutant Strains Mice><Myeloid Cell Activation><Myeloid Cells><Myelopoiesis><Mφ><Older Population><Osteoblasts><Osteoclastic Bone Loss><Osteoclasts><Osteoporosis><Osteoporosis prevention><Pathway interactions><Persons><Phenotype><Play><Position><Positioning Attribute><Pre-Clinical Model><Preclinical Models><Preventative strategy><Prevention strategy><Preventive strategy><Production><QOL><Qualifying><Quality of life><Receptor Protein><Recombinant Proteins><Research><Resistance><Role><Signal Transduction><Signal Transduction Systems><Signaling><Societies><Source><Stimulus><Stretching><Structure><Sympathetic Nervous System><Systemic hypertension><T cell factor 1><T cell transcription factor 1><T-Cell Activation><TCF-1 protein><Techniques><Technology><Testing><Therapeutic Estrogen><Vascular Endothelium><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Vascular remodeling><Veiled Cells><Withdrawal><Work><activate T cells><adult animal><adulthood><age associated decline><age dependent decline><age related decline><age-associated bone loss><aged><aged mice><aged mouse><ages><aging associated disease><aging associated disorders><aging prevention><aging related disease><aging related disorders><antagonism><antagonist><anti aging><anti geronic><antiaging><arteriole><bacteriophage P1 recombinase Cre><biological signal transduction><blood pressure elevation><blood pressure reduction><bone><bone fracture><bone loss><bone loss with aging><bone mass><bone quality><bone strength><cell culture><cell cultures><cellular differentiation><cytokine><decline with age><designer receptors exclusively activated by designer drugs><disease associated with aging><disease model><disease of aging><disorder model><disorder of aging><disorders associated with aging><disorders related to aging><early detection><early therapy><elderly mice><elevated blood pressure><experiment><experimental research><experimental study><experiments><fracture risk><fragility fracture><hemopoietic><high blood pressure><hyperpiesia><hyperpiesis><hypertensive><hypertensive disease><hypertensive disorder><immune activation><improved><increase in blood pressure><increased blood pressure><individuals with osteoporosis><induced Cre><inducible Cre><life span><lifespan><long bone><lower BP><lower blood pressure><lowers blood pressure><mature animal><mechanic><mechanical><mechanical force><monocyte><mouse model><mouse mutant><multidisciplinary><murine model><neutralizing antibody><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><old mice><older groups><older individuals><older person><osteoporosis individuals><osteoporosis patients><osteoporosis people><osteoporosis population><osteoporotic individual><osteoporotic patients><osteoporotic population><pathway><patients with osteoporosis><people with osteoporosis><population with osteoporosis><postnatal><premature><prematurity><prevent><prevent age related><prevent aging><prevent osteoporosis><preventing><receptor><reduce BP><reduce blood pressure><reduction in BP><reduction in blood pressure><release factor><resistant><response><skills><social role><success><suppress aging><tool><translatable strategy><translational goal><translational mission><treatment strategy><vascular constriction><vasoconstriction><venule>

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Jeffry Stephen Nyman

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$509,817

FY 2026

Project Title

Common Inflammation Pathways between Aging and Hypertension That Weaken Bone

Grant Number:

5R01AG076785-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary / Abstract Osteoporosis is under diagnosed and under treated. It is essential that we develop novel tools for early detection and treatment strategies to reduce the number of fragility fractures that accompany aging. Systemic hypertension is another disease of aging that commonly co-...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Age><Age-Related Bone Loss><Aging><American Heart Association><Animals><Antibodies><Assay><BP reduction><Bioassay><Biological Assay><Biology><Blood Pressure><Blood Pressure Monitors><Blood monocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Resorption><Bone remodeling><CRE Recombinase><CSF-1><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cells><Cessation of life><Clinical Pharmacology><Co-culture><Cocultivation><Coculture><Coculture Techniques><Collaborations><Colony-Stimulating Factor 1><Communication><Continuous Sphygmomanometers><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><DREADDs><Data><Death><Dendritic Cells><Denervation><Deterioration><Diagnosis><Disease><Disorder><Early Diagnosis><Early treatment><Economic Burden><Endothelial Cells><Endothelium><Enterobacteria phage P1 Cre recombinase><Estrogens><Exposure to><Fracture><Genes><Goals><Health><Hematopoietic><Hip Fractures><Human><Hypertension><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immune><Immune Cell Activation><Immunes><Individual><Inflammation><Inflammatory><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Interleukins><Intracellular Communication and Signaling><M-CSF><Macrophage><Macrophage Colony-Stimulating Factor><Marrow monocyte><Measurement><Mechanical Stimulation><Mechanics><Mediating><Mediator><Menopause><Methodology><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><Mutant Strains Mice><Myeloid Cell Activation><Myeloid Cells><Myelopoiesis><Mφ><Older Population><Osteoblasts><Osteoclastic Bone Loss><Osteoclasts><Osteoporosis><Osteoporosis prevention><Pathway interactions><Persons><Phenotype><Play><Position><Positioning Attribute><Pre-Clinical Model><Preclinical Models><Preventative strategy><Prevention strategy><Preventive strategy><Production><QOL><Qualifying><Quality of life><Receptor Protein><Recombinant Proteins><Research><Resistance><Role><Signal Transduction><Signal Transduction Systems><Signaling><Societies><Source><Stimulus><Stretching><Structure><Sympathetic Nervous System><Systemic hypertension><T cell factor 1><T cell transcription factor 1><T-Cell Activation><TCF-1 protein><Techniques><Technology><Testing><Therapeutic Estrogen><Vascular Endothelium><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Vascular remodeling><Veiled Cells><Withdrawal><Work><activate T cells><adult animal><adulthood><age associated decline><age dependent decline><age related decline><age-associated bone loss><aged><aged mice><aged mouse><ages><aging associated disease><aging associated disorders><aging prevention><aging related disease><aging related disorders><antagonism><antagonist><anti aging><anti geronic><antiaging><arteriole><bacteriophage P1 recombinase Cre><biological signal transduction><blood pressure elevation><blood pressure reduction><bone><bone fracture><bone loss><bone loss with aging><bone mass><bone quality><bone strength><cell culture><cell cultures><cellular differentiation><cytokine><decline with age><designer receptors exclusively activated by designer drugs><disease associated with aging><disease model><disease of aging><disorder model><disorder of aging><disorders associated with aging><disorders related to aging><early detection><early therapy><elderly mice><elevated blood pressure><experiment><experimental research><experimental study><experiments><fracture risk><fragility fracture><hemopoietic><high blood pressure><hyperpiesia><hyperpiesis><hypertensive><hypertensive disease><hypertensive disorder><immune activation><improved><increase in blood pressure><increased blood pressure><individuals with osteoporosis><induced Cre><inducible Cre><life span><lifespan><long bone><lower BP><lower blood pressure><lowers blood pressure><mature animal><mechanic><mechanical><mechanical force><monocyte><mouse model><mouse mutant><multidisciplinary><murine model><neutralizing antibody><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><old mice><older groups><older individuals><older person><osteoporosis individuals><osteoporosis patients><osteoporosis people><osteoporosis population><osteoporotic individual><osteoporotic patients><osteoporotic population><pathway><patients with osteoporosis><people with osteoporosis><population with osteoporosis><postnatal><premature><prematurity><prevent><prevent age related><prevent aging><prevent osteoporosis><preventing><receptor><reduce BP><reduce blood pressure><reduction in BP><reduction in blood pressure><release factor><resistant><response><skills><social role><success><suppress aging><tool><translatable strategy><translational goal><translational mission><treatment strategy><vascular constriction><vasoconstriction><venule>

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Ya-Chieh Hsu

HARVARD UNIVERSITY, CAMBRIDGE, MA

Good lead · 60/100

Likely hiring

Above-average budget

Active award

$509,224

FY 2026

Project Title

Aging and Rejuvenation of Skin Stem Cells

Grant Number:

5R01AR083416-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award size is strong enough to merit immediate review.

Project Abstract

Project Summary The regenerative capacity of stem cells diminishes as we age. In the case of hair follicle stem cells (HFSCs), this loss manifests as a sustained dormancy phase without regenerating new hair follicles. Although we have gained substantial insight into the molecular differences between...

Research Terms

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Dong Yan

DUKE UNIVERSITY, DURHAM, NC

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$493,267

FY 2026

Project Title

Use of C. elegans as a model to study aging-associated neurodegeneration

Grant Number:

5R01AG073994-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Aging can cause neurodegeneration and is also a major risk factor for neurodegenerative diseases. However, the molecular mechanisms underlying aging-associated neurodegeneration are not well understood yet. Therefore, our-long-term goal is to understand the molecular mechanisms undying neurodeg...

Research Terms

<13 year old><13 years of age><AD patients><Aging><Alzheimer's disease patient><Alzheimer's patient><Animals><Astrocytes><Astrocytus><Astroglia><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clinical Research><Clinical Study><Common Rat Strains><Data><Degenerative Neurologic Disorders><Development><Disease><Disorder><Gene Transcription><GeneHomolog><Generations><Genetic><Genetic Screening><Genetic Transcription><Genomics><Glia><Glial Cells><Goals><Homolog><Homologous Gene><Homologue><Host Defense><Human><Immune response><Immune signaling><Infection><Intracellular Communication and Signaling><Kolliker's reticulum><Lead><Mammalia><Mammals><Methods><Modeling><Modern Man><Molecular><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurites><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neuroglia><Neuroglial Cells><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Neuropeptide Receptor><Non-neuronal cell><Nonneuronal cell><Outcome><Pathogenesis><Pb element><Peptide Receptor><Peptide Signal Sequences><Peptides><Play><Population><Post-Transcriptional Gene Silencing><Probability><Protein Biosynthesis><Publishing><Punishment><RNA Expression><RNA Interference><RNA Silencing><RNAi><Rat><Rats Mammals><Rattus><Regulation><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Risk Factors><Role><Sequence-Specific Posttranscriptional Gene Silencing><Signal Peptide><Signal Sequences><Signal Transduction><Signal Transduction Systems><Signaling><Structure><System><Transcription><Work><age 13><age 13 years><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age related neurodegeneration><age related pathways><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><aged><aged animal><aged animals><aged rodent><aged rodents><aging associated><aging associated disease><aging associated disorders><aging associated mechanism><aging associated neurodegeneration><aging associated neurodegenerative disease><aging mechanism><aging pathway><aging related><aging related disease><aging related disorders><aging related mechanism><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><aging related pathways><animal old age><anti-microbial peptide><astrocytic glia><biological mechanism of age><biological pathways of age><biological signal transduction><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><driving force><elderly animal><elderly rodent><heavy metal Pb><heavy metal lead><host response><immune system response><immunoresponse><mechanism regulating aging><mechanisms involved in aging><model organism><nerve cement><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><old animals><old rodent><overexpress><overexpression><pathway involved in aging><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><preservation><prevent><preventing><protein signal sequence><protein synthesis><social role><thirteen year old><thirteen years of age><tool>

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DORIS A GERMAIN

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$481,424

FY 2026

Project Title

Understanding the influence of Mitochondrial DNA haplotypes on breast aging and cancer

Grant Number:

5R01AG075589-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

The rate of aging of the breast differs between women. Further, older women tend to develop estrogen receptor alpha (ERα) positive breast cancer sub-type, despite lower hormonal levels. Our preliminary data compel us to hypothesize that mitochondrial genetics alters the rate of aging of the breast a...

Research Terms

<100+ years old><Affect><African><Age><Aging><Agreement><Alveolar><Alveolar Cell><Automobile Driving><Basal Cell><Bittner Virus><Breast><Breast Cancer><Breast Cancer Model><Breast Neoplasms><Breast Tumors><Breast tumor model><Cancer Genes><Cancer-Promoting Gene><Cancers><Causality><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Centenarian><Complex><Corpus Luteum Hormone><Data><Delta4-pregnene-3,20-dione><ERBB2><ERBB2 gene><ERalpha><ERα><ESR1><ESR1 gene><Endocrine Gland Secretion><Endoplasmic Reticulum><Ergastoplasm><Estradiol Receptor alpha><Estradiol Receptor α><Estrogen Receptor 1><Estrogen Receptor alpha><Estrogen Receptor α><Estrogens><Etiology><European><Evolution><Female><Gene Transcription><Genetic><Genetic Transcription><Genome><Genotype><HER -2><HER-2><HER2><HER2 Genes><HER2/neu><Haplotypes><Hormonal><Hormones><Individual><Injections><Intracellular Communication and Signaling><MMTV><Malignant Breast Neoplasm><Malignant Neoplasms><Malignant Tumor><Mammary Cancer><Mammary Cancer Virus><Mammary Duct><Mammary Neoplasms><Mammary gland><Mediating><Menopause><Mice><Mice Mammals><Mitochondria><Mitochondrial DNA><Monitor><Mouse Mammary Tumor Virus><Murine><Mus><NEU Oncogene><NEU protein><NR3A1><Nuclear><Oncogene ErbB2><Oncogenes><Oxidative Stress><Perimenopausal><Perimenopause><Population><Post-Menopause><Post-menopausal Period><Postmenopausal Period><Postmenopause><Pre-Menopause><Pre-menopausal Period><Predisposition><Pregn-4-ene-3,20-dione><Pregnenedione><Premenopausal><Premenopausal Period><Premenopause><Progesterone><Proteins><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Regulation><Retroviridae><Retroviruses><Risk Factors><Role><Signal Transduction><Signal Transduction Systems><Signaling><Silent Mating Type Information Regulator 2-like Proteins><Single Base Polymorphism><Single Nucleotide Polymorphism><Sir2-like Proteins><Sirtuins><Stress><Susceptibility><TKR1><Testing><Therapeutic Estrogen><Therapeutic Hormone><Therapeutic Progesterone><Transcription><Transforming Genes><Transgenic Mice><Transgenic Organisms><Trees><Virus-Retrovirus><Woman><adult youth><after menopause><age associated decline><age dependent decline><age related decline><aged><aged mice><aged mouse><ages><biological signal transduction><c-erbB-2><c-erbB-2 Genes><c-erbB-2 Proto-Oncogenes><cancer sub-types><cancer subtypes><causation><centenarian human (100+)><decline with age><disease causation><driving><elderly mice><erbB-2 Genes><following menopause><gain of function><global gene expression><global transcription profile><herstatin><high risk><loss of function><malignancy><malignant breast tumor><mammary><mammary cancer model><mammary tumor><mammary tumor model><menopause transition><milk agent><mitochondria fitness><mitochondrial><mitochondrial fitness><mouse model><mtDNA><murine model><neoplasm/cancer><neu Genes><old mice><older women><pace of aging><pace of biological aging><past menopause><peri-menopausal><peri-menopause><post-menopausal><postmenopausal><postmenopausal status><pre-menopausal><premenopausal status><preservation><programs><promoter><promotor><rate of aging><rate of biological aging><receptor><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single nucleotide variant><single-cell RNA sequencing><social role><speed of aging><speed of the aging><transcriptome><transcriptome sequencing><transcriptomic sequencing><transgene expression><transgenic><transition to menopause><transitional menopause><tumor><young adult><young adult age><young adulthood><♀>

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Laura M Calvi

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$461,992

FY 2026

Project Title

Efferocytosis by Bone Marrow Stromal Cells and Bone Aging

Grant Number:

5R01AG076786-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Efferocytosis by bone marrow stromal cells and bone aging Pre-clinical studies show that senescent bone marrow-derived mesenchymal stromal (a.k.a. stem) cells (MSCs) and osteolineage cells contribute to age-dependent bone loss and bone marrow failure. Therefore, the identification of novel mechanism...

Research Terms

<21+ years old><AMD-3100><AMD3100><Acceleration><Active Oxygen><Address><Adult><Adult Human><Aging><Apoptosis><Apoptosis Pathway><Apoptotic><Autoregulation><BAI1><BAI1 gene><BM Stem Cell><BM derived progenitor><BM progenitor><BM- derived Stem Cells><Beta Proprotein Interleukin 1><Biology><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Marrow Stem Cell><Bone Marrow progenitor><Bone marrow failure><Brain-specific Angiogenesis Inhibitor 1><Breast Cancer><CDw128b><CMKAR2><COPD><CXC-R4><CXCL1><CXCL1 gene><CXCL12><CXCL12 gene><CXCL12 protein><CXCR-4><CXCR2><CXCR4><CXCR4 gene><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cell Senescence Induction><Cell Signaling><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Chemokine (C-X-C Motif) Ligand 12><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clinical Trials><D2S201E><DNA Recombination><Data><Degenerative Disorder><Development><Disease><Disorder><Dose><Dysfunction><FB22><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional disorder><GRO1><GROA><Gene Transcription><Genetic Models><Genetic Recombination><Genetic Transcription><Goals><HM89><HSY3RR><Health><Homeostasis><Human><IGF-1><IGF-I><IGF-I-SmC><IL-1><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL1><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><IL8R2><IL8RB><IL8RB gene><Immune><Immunes><Impairment><In Vitro><Inflammation><Inflammatory><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Interleukin 1beta><Interleukin I><Interleukin-1><Interleukin-1 beta><Interleukin-1β><Intracellular Communication and Signaling><Knowledge><LAP3><LCR1><LESTR><Label><Length of Life><Longevity><Lymphocyte-Stimulating Hormone><MGSA><Macrophage><Macrophage Cell Factor><Maintenance><Malignant Breast Neoplasm><Malignant Pancreatic Neoplasm><Malignant neoplasm of pancreas><Marrow Neutrophil><Measures><Mediating><Mesenchymal><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Metabolic><Metals><Mice><Mice Mammals><Mission><Mitochondria><Modeling><Modern Man><Molecular><Murine><Mus><Mφ><NIH><NPY3R><NPYR><NPYRL><NPYY3R><National Institutes of Health><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxidative Stress><Oxidative Stress Induction><Oxygen Radicals><PBSF><Pancreas Cancer><Pancreatic Cancer><Pathogenicity><Pathologic><Phagocytes><Phagocytic Cell><Phagocytosis><Phenotype><Physiological Homeostasis><Physiology><Physiopathology><Plerixafor><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Pre-B Cell Growth Stimulating Factor><Preinterleukin 1 Beta><Pro-Oxidants><Process><Programmed Cell Death><Public Health><RNA Expression><Reactive Oxygen Species><Receptor Protein><Recombination><Replicative Senescence><Reporting><Role><SCYB1><SCYB12><SDF-1><SDF-1A><SDF-1B><SDF-1alpha><SDF1><SDF1A><SDF1B><Sdf1 protein><Signal Transduction><Signal Transduction Systems><Signaling><Skeleton><Somatomedin C><Stromal Cell-Derived Factor 1><Subcellular Process><T Helper Factor><TLSF-A><TLSF-B><TPAR1><Tamoxifen><Testing><Transcription><Transgenic Organisms><United States National Institutes of Health><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged bone><aged mice><aged mouse><amebocyte><antagonism><antagonist><anti-oxidant enzyme><antioxidant enzyme><biological signal transduction><biomechanical analyses><biomechanical analysis><biomechanical assessment><biomechanical characterization><biomechanical evaluation><biomechanical measurement><biomechanical profiling><biomechanical test><bone><bone aging><bone health><bone loss><bone marrow derived progenitor><bone marrow derived stem cells><bone marrow stromal cell><bone marrow stromal stem cell><bone repair><bone turnover><catalase><cellular aging induction><cellular senescence induction><chronic obstructive pulmonary disorder><compound repositioning><compound repurposing><degenerative condition><degenerative disease><developmental><disability><drug repositioning><drug repurposing><elderly mice><flow cytophotometry><gain of function><hIRH><improved><in vivo><inhibitor><innovate><innovation><innovative><loss of function><lymphocyte activating factor><malignant breast tumor><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><mitochondrial><mitochondrial dysfunction><mouse model><murine model><neutrophil><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic uses for existing drugs><new therapeutics><new therapy><new use of drug><new uses for an approved drug><new uses for existing drugs><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><old mice><osteoblast cell differentiation><osteoblast differentiation><osteoblastic differentiation><osteogenic><osteoimmunology><overexpress><overexpression><pancreatic malignancy><particle><pathogen><pathophysiology><pharmacologic><pharmacological repurposing><pre-clinical study><preclinical study><prevent><preventing><pro-aging><progeronic><programs><promote aging><receptor><replicative aging><repositioning approved drugs><repositioning existing drugs><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><response><scRNA sequencing><scRNA-seq><senescence><senescence induction><senescent><serine receptor><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skeletal><skeletons><social role><stem><stromal cell-derived factor-1alpha><therapeutic repositioning><therapeutic repurposing><transgenic>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Roman Eliseev

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$461,992

FY 2026

Project Title

Efferocytosis by Bone Marrow Stromal Cells and Bone Aging

Grant Number:

5R01AG076786-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Efferocytosis by bone marrow stromal cells and bone aging Pre-clinical studies show that senescent bone marrow-derived mesenchymal stromal (a.k.a. stem) cells (MSCs) and osteolineage cells contribute to age-dependent bone loss and bone marrow failure. Therefore, the identification of novel mechanism...

Research Terms

<21+ years old><AMD-3100><AMD3100><Acceleration><Active Oxygen><Address><Adult><Adult Human><Aging><Apoptosis><Apoptosis Pathway><Apoptotic><Autoregulation><BAI1><BAI1 gene><BM Stem Cell><BM derived progenitor><BM progenitor><BM- derived Stem Cells><Beta Proprotein Interleukin 1><Biology><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Marrow Stem Cell><Bone Marrow progenitor><Bone marrow failure><Brain-specific Angiogenesis Inhibitor 1><Breast Cancer><CDw128b><CMKAR2><COPD><CXC-R4><CXCL1><CXCL1 gene><CXCL12><CXCL12 gene><CXCL12 protein><CXCR-4><CXCR2><CXCR4><CXCR4 gene><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cell Senescence Induction><Cell Signaling><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Chemokine (C-X-C Motif) Ligand 12><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clinical Trials><D2S201E><DNA Recombination><Data><Degenerative Disorder><Development><Disease><Disorder><Dose><Dysfunction><FB22><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional disorder><GRO1><GROA><Gene Transcription><Genetic Models><Genetic Recombination><Genetic Transcription><Goals><HM89><HSY3RR><Health><Homeostasis><Human><IGF-1><IGF-I><IGF-I-SmC><IL-1><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL1><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><IL8R2><IL8RB><IL8RB gene><Immune><Immunes><Impairment><In Vitro><Inflammation><Inflammatory><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Interleukin 1beta><Interleukin I><Interleukin-1><Interleukin-1 beta><Interleukin-1β><Intracellular Communication and Signaling><Knowledge><LAP3><LCR1><LESTR><Label><Length of Life><Longevity><Lymphocyte-Stimulating Hormone><MGSA><Macrophage><Macrophage Cell Factor><Maintenance><Malignant Breast Neoplasm><Malignant Pancreatic Neoplasm><Malignant neoplasm of pancreas><Marrow Neutrophil><Measures><Mediating><Mesenchymal><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Metabolic><Metals><Mice><Mice Mammals><Mission><Mitochondria><Modeling><Modern Man><Molecular><Murine><Mus><Mφ><NIH><NPY3R><NPYR><NPYRL><NPYY3R><National Institutes of Health><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxidative Stress><Oxidative Stress Induction><Oxygen Radicals><PBSF><Pancreas Cancer><Pancreatic Cancer><Pathogenicity><Pathologic><Phagocytes><Phagocytic Cell><Phagocytosis><Phenotype><Physiological Homeostasis><Physiology><Physiopathology><Plerixafor><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Pre-B Cell Growth Stimulating Factor><Preinterleukin 1 Beta><Pro-Oxidants><Process><Programmed Cell Death><Public Health><RNA Expression><Reactive Oxygen Species><Receptor Protein><Recombination><Replicative Senescence><Reporting><Role><SCYB1><SCYB12><SDF-1><SDF-1A><SDF-1B><SDF-1alpha><SDF1><SDF1A><SDF1B><Sdf1 protein><Signal Transduction><Signal Transduction Systems><Signaling><Skeleton><Somatomedin C><Stromal Cell-Derived Factor 1><Subcellular Process><T Helper Factor><TLSF-A><TLSF-B><TPAR1><Tamoxifen><Testing><Transcription><Transgenic Organisms><United States National Institutes of Health><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged bone><aged mice><aged mouse><amebocyte><antagonism><antagonist><anti-oxidant enzyme><antioxidant enzyme><biological signal transduction><biomechanical analyses><biomechanical analysis><biomechanical assessment><biomechanical characterization><biomechanical evaluation><biomechanical measurement><biomechanical profiling><biomechanical test><bone><bone aging><bone health><bone loss><bone marrow derived progenitor><bone marrow derived stem cells><bone marrow stromal cell><bone marrow stromal stem cell><bone repair><bone turnover><catalase><cellular aging induction><cellular senescence induction><chronic obstructive pulmonary disorder><compound repositioning><compound repurposing><degenerative condition><degenerative disease><developmental><disability><drug repositioning><drug repurposing><elderly mice><flow cytophotometry><gain of function><hIRH><improved><in vivo><inhibitor><innovate><innovation><innovative><loss of function><lymphocyte activating factor><malignant breast tumor><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><mitochondrial><mitochondrial dysfunction><mouse model><murine model><neutrophil><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic uses for existing drugs><new therapeutics><new therapy><new use of drug><new uses for an approved drug><new uses for existing drugs><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><old mice><osteoblast cell differentiation><osteoblast differentiation><osteoblastic differentiation><osteogenic><osteoimmunology><overexpress><overexpression><pancreatic malignancy><particle><pathogen><pathophysiology><pharmacologic><pharmacological repurposing><pre-clinical study><preclinical study><prevent><preventing><pro-aging><progeronic><programs><promote aging><receptor><replicative aging><repositioning approved drugs><repositioning existing drugs><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><response><scRNA sequencing><scRNA-seq><senescence><senescence induction><senescent><serine receptor><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skeletal><skeletons><social role><stem><stromal cell-derived factor-1alpha><therapeutic repositioning><therapeutic repurposing><transgenic>

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Rama K Mallampalli

OHIO STATE UNIVERSITY, Columbus, OH

Good lead · 58/100

Training-friendly

Solid budget

Very recent

Active award

$451,676

FY 2026

Project Title

Training Program in the Biology of Aging and Lung Diseases

Grant Number:

5T32HL166132-03

Activity Code:

T32

Mechanism:

Training, Institutional

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The lung is a major determinant of human health and respiratory diseases are a leading cause of morbidity and mortality among the elderly. The elderly population is one of the fastest-growing demographics in the US and worldwide. Our innovative T32 program in Biology of Aging and Pulmonary Diseases ...

Research Terms

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Ana Lucia Mora

OHIO STATE UNIVERSITY, Columbus, OH

Good lead · 58/100

Training-friendly

Solid budget

Very recent

Active award

$451,676

FY 2026

Project Title

Training Program in the Biology of Aging and Lung Diseases

Grant Number:

5T32HL166132-03

Activity Code:

T32

Mechanism:

Training, Institutional

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The lung is a major determinant of human health and respiratory diseases are a leading cause of morbidity and mortality among the elderly. The elderly population is one of the fastest-growing demographics in the US and worldwide. Our innovative T32 program in Biology of Aging and Pulmonary Diseases ...

Research Terms

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William H Dow

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$431,988

FY 2026

Project Title

Costa Rican Longevity and Healthy Aging Study (CRELES): Wave 4

Grant Number:

3R01AG091512-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary / Abstract Costa Rican Longevity and Healthy Aging Study (CRELES): Wave 4 Costa Rica has been long recognized as an important country to study based on its achievement of “good health at low cost.” Despite being a middle-income country, its life expectancy is among the highest in Lat...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><ADRD><Achievement><Achievement Attainment><Active Follow-up><Adult><Adult Human><Age><Aging><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Amentia><Biological Markers><Birth><Blood><Blood Reticuloendothelial System><Cessation of life><Cognitive><Cognitive aging><Communities><Costa Rica><Costa Rican><Country><Data><Data Set><Death><Dementia><Economic Income><Economical Income><Family Research><Geography><Health><Health Expenditures><Health and Retirement Study><Income><International><Interview><Investments><LMIC><Latin America><Length of Life><Life Expectancy><Long-term Follow-up><Longevity><Married Persons><Measurement><Mexico><National Academy of Sciences><Parturition><Pattern><Performance><Population><Protocol><Protocols documentation><Puerto Rico><Questionnaires><Research><Respondent><Rest><Retirement><Running><Sample Size><Sampling Studies><Socio-economic status><Socioeconomic Status><Spouses><Survey Instrument><Surveys><Survivors><Time><United States><United States National Academy of Sciences><Update><Venous><Vital Statistics><Work><active followup><adulthood><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging population><bio-markers><biologic marker><biomarker><burden of chronic disease><burden of chronic illness><cognitive assessment><cognitive performance><cognitive testing><cohort><cost><design><designing><family based research><family centered research><family focused research><family investigation><follow up><follow-up><followed up><followup><health care expenditure><health data><healthy aging><healthy human aging><incomes><indexing><informant><innovate><innovation><innovative><investigate family><long-term followup><low and middle-income countries><medical expenditure><mortality><old age><older adult><older adulthood><performance tests><physical conditioning><physical health><population aging><retirements><safety net><social><socio-economic><socio-economic position><socio-economically><socioeconomic position><socioeconomically><socioeconomics><study family><success><survey family>

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Amanda Emerson

UNIVERSITY OF KANSAS MEDICAL CENTER, KANSAS CITY, KS

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$424,897

FY 2026

Project Title

Aging-Related Health and Aging Acceleration in Older Women with Criminal Legal System Involvement (AGELIS)

Grant Number:

1R01NR021186-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/18/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY There are over 177,000 women detained in U.S. jails and prisons on any day and another 800,000 serving sentences in the community under custodial supervision. About 20% of women with criminal legal system involvement (CLSI) are age 50 or older. Rates of women and older adults have bo...

Research Terms

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David E Kaplan

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$405,196

FY 2026

Project Title

Impact of mammalian target of rapamycin inhibitor therapy on aging-related outcomes

Grant Number:

5R01AG079911-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY In numerous experimental studies, mammalian target of rapamycin (mTOR) inhibitors, such as rapamycin, prolong lifespan, prevent the progression of Alzheimer's disease and related dementias (AD/ADRD) and improve multiple other age-dependent processes. However, there are limited clinic...

Research Terms

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DOUGLAS EARL SCHAUBEL

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$405,196

FY 2026

Project Title

Impact of mammalian target of rapamycin inhibitor therapy on aging-related outcomes

Grant Number:

5R01AG079911-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY In numerous experimental studies, mammalian target of rapamycin (mTOR) inhibitors, such as rapamycin, prolong lifespan, prevent the progression of Alzheimer's disease and related dementias (AD/ADRD) and improve multiple other age-dependent processes. However, there are limited clinic...

Research Terms

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Allison E Aiello

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$355,085

FY 2026

Project Title

Testing effects of cash transfers on biological aging and risk for Alzheimer's Disease

Grant Number:

5R01AG087158-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Alzheimer's Disease (AD) and AD-Related Disorders (AD/ADRD) are significantly increasing in resource-limited areas, where improved nutrition and decreased infectious disease mortality are enabling population aging. Simultaneously, enduring elevated levels of early-life adversity and adult hardship a...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><Acceleration><Activities of Daily Living><Activities of everyday life><Address><Adult><Adult Human><Africa><Africa South of the Sahara><Age><Aging><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Assay><Bioassay><Biological><Biological Aging><Biological Assay><Blood><Blood Reticuloendothelial System><Cell Body><Cells><Chronic Disease><Chronic Illness><Cognition><Cognitive aging><Communicable Diseases><Consumption><Control Groups><DNA Methylation><Data><Dementia><Development><Disease><Disease Outcome><Disorder><Dryness><EOAD><Early Onset Alzheimer Disease><Economics><Exhibits><Generations><Government><GrimAge clock><Hannum clock><Health><Health Benefit><Horvath clock><Household><Hypertension><Immune><Immunes><Immunity><Individual><Infectious Diseases><Infectious Disorder><Influentials><International><Intervention><Knowledge><Life><Link><Long-term Follow-up><Longitudinal Studies><Longitudinal Surveys><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Malawi><Measurement><Measures><Methods><Neurocognitive><Nutrition><Nyasaland><Obesity><Older Population><Participant><Pattern><PhenoAge clocks><Phenotype><Population><Prevalence><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Public Health><Randomization trial><Randomized, Controlled Trials><Research><Research Specimen><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Risk Factors><Risk Reduction><Role><Sampling><South Africa><Specimen><Spottings><Sub-Saharan Africa><Subsaharan Africa><Survey Instrument><Surveys><Testing><Time><Underweight><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Waiting Lists><accelerated aging><accelerated biological age><accelerated biological aging><adiposity><adult youth><adulthood><age acceleration><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging associated><aging associated disease><aging associated disorders><aging population><aging related><aging related disease><aging related disorders><alzheimer risk><biologic><biological age><biological process of age><burden of disease><burden of illness><chronic disorder><cognitive assessment><cognitive function><cognitive testing><cohort><corpulence><daily living function><daily living functionality><dementia risk><developmental><disease associated with aging><disease burden><disease of aging><disease risk><disorder of aging><disorder risk><disorders associated with aging><disorders related to aging><early adversity><early childhood adversity><early life adversity><early onset AD><early onset Alzheimer's><economic><epigenetic age clocks><epigenetic clock><epigenetic molecular clocks><experience><functional ability><functional capacity><healthspan><healthy life span><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><innovate><innovation><innovative><insight><intervention effect><life span><lifespan><long-term followup><long-term study><longitudinal outcome studies><longitudinal research study><methylation clock><mortality><neurocognitive test><novel><older adult><older adulthood><older groups><older individuals><older person><pace of aging><pace of biological aging><pathogen><population aging><prevent><preventing><primary degenerative dementia><programs><randomized control trial><randomized trial><rate of aging><rate of biological aging><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><risk-reducing><senile dementia of the Alzheimer type><social><social role><speed of aging><speed of the aging><tool><treatment group><waitlist><young adult><young adult age><young adulthood>

View Full Project Details on NIH Reporter

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Daniel Walker Belsky

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$355,085

FY 2026

Project Title

Testing effects of cash transfers on biological aging and risk for Alzheimer's Disease

Grant Number:

5R01AG087158-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Alzheimer's Disease (AD) and AD-Related Disorders (AD/ADRD) are significantly increasing in resource-limited areas, where improved nutrition and decreased infectious disease mortality are enabling population aging. Simultaneously, enduring elevated levels of early-life adversity and adult hardship a...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><Acceleration><Activities of Daily Living><Activities of everyday life><Address><Adult><Adult Human><Africa><Africa South of the Sahara><Age><Aging><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Assay><Bioassay><Biological><Biological Aging><Biological Assay><Blood><Blood Reticuloendothelial System><Cell Body><Cells><Chronic Disease><Chronic Illness><Cognition><Cognitive aging><Communicable Diseases><Consumption><Control Groups><DNA Methylation><Data><Dementia><Development><Disease><Disease Outcome><Disorder><Dryness><EOAD><Early Onset Alzheimer Disease><Economics><Exhibits><Generations><Government><GrimAge clock><Hannum clock><Health><Health Benefit><Horvath clock><Household><Hypertension><Immune><Immunes><Immunity><Individual><Infectious Diseases><Infectious Disorder><Influentials><International><Intervention><Knowledge><Life><Link><Long-term Follow-up><Longitudinal Studies><Longitudinal Surveys><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Malawi><Measurement><Measures><Methods><Neurocognitive><Nutrition><Nyasaland><Obesity><Older Population><Participant><Pattern><PhenoAge clocks><Phenotype><Population><Prevalence><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Public Health><Randomization trial><Randomized, Controlled Trials><Research><Research Specimen><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Risk Factors><Risk Reduction><Role><Sampling><South Africa><Specimen><Spottings><Sub-Saharan Africa><Subsaharan Africa><Survey Instrument><Surveys><Testing><Time><Underweight><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Waiting Lists><accelerated aging><accelerated biological age><accelerated biological aging><adiposity><adult youth><adulthood><age acceleration><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging associated><aging associated disease><aging associated disorders><aging population><aging related><aging related disease><aging related disorders><alzheimer risk><biologic><biological age><biological process of age><burden of disease><burden of illness><chronic disorder><cognitive assessment><cognitive function><cognitive testing><cohort><corpulence><daily living function><daily living functionality><dementia risk><developmental><disease associated with aging><disease burden><disease of aging><disease risk><disorder of aging><disorder risk><disorders associated with aging><disorders related to aging><early adversity><early childhood adversity><early life adversity><early onset AD><early onset Alzheimer's><economic><epigenetic age clocks><epigenetic clock><epigenetic molecular clocks><experience><functional ability><functional capacity><healthspan><healthy life span><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><innovate><innovation><innovative><insight><intervention effect><life span><lifespan><long-term followup><long-term study><longitudinal outcome studies><longitudinal research study><methylation clock><mortality><neurocognitive test><novel><older adult><older adulthood><older groups><older individuals><older person><pace of aging><pace of biological aging><pathogen><population aging><prevent><preventing><primary degenerative dementia><programs><randomized control trial><randomized trial><rate of aging><rate of biological aging><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><risk-reducing><senile dementia of the Alzheimer type><social><social role><speed of aging><speed of the aging><tool><treatment group><waitlist><young adult><young adult age><young adulthood>

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sudhanshu Handa

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$355,085

FY 2026

Project Title

Testing effects of cash transfers on biological aging and risk for Alzheimer's Disease

Grant Number:

5R01AG087158-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Alzheimer's Disease (AD) and AD-Related Disorders (AD/ADRD) are significantly increasing in resource-limited areas, where improved nutrition and decreased infectious disease mortality are enabling population aging. Simultaneously, enduring elevated levels of early-life adversity and adult hardship a...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><Acceleration><Activities of Daily Living><Activities of everyday life><Address><Adult><Adult Human><Africa><Africa South of the Sahara><Age><Aging><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Assay><Bioassay><Biological><Biological Aging><Biological Assay><Blood><Blood Reticuloendothelial System><Cell Body><Cells><Chronic Disease><Chronic Illness><Cognition><Cognitive aging><Communicable Diseases><Consumption><Control Groups><DNA Methylation><Data><Dementia><Development><Disease><Disease Outcome><Disorder><Dryness><EOAD><Early Onset Alzheimer Disease><Economics><Exhibits><Generations><Government><GrimAge clock><Hannum clock><Health><Health Benefit><Horvath clock><Household><Hypertension><Immune><Immunes><Immunity><Individual><Infectious Diseases><Infectious Disorder><Influentials><International><Intervention><Knowledge><Life><Link><Long-term Follow-up><Longitudinal Studies><Longitudinal Surveys><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Malawi><Measurement><Measures><Methods><Neurocognitive><Nutrition><Nyasaland><Obesity><Older Population><Participant><Pattern><PhenoAge clocks><Phenotype><Population><Prevalence><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Public Health><Randomization trial><Randomized, Controlled Trials><Research><Research Specimen><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Risk Factors><Risk Reduction><Role><Sampling><South Africa><Specimen><Spottings><Sub-Saharan Africa><Subsaharan Africa><Survey Instrument><Surveys><Testing><Time><Underweight><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Waiting Lists><accelerated aging><accelerated biological age><accelerated biological aging><adiposity><adult youth><adulthood><age acceleration><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging associated><aging associated disease><aging associated disorders><aging population><aging related><aging related disease><aging related disorders><alzheimer risk><biologic><biological age><biological process of age><burden of disease><burden of illness><chronic disorder><cognitive assessment><cognitive function><cognitive testing><cohort><corpulence><daily living function><daily living functionality><dementia risk><developmental><disease associated with aging><disease burden><disease of aging><disease risk><disorder of aging><disorder risk><disorders associated with aging><disorders related to aging><early adversity><early childhood adversity><early life adversity><early onset AD><early onset Alzheimer's><economic><epigenetic age clocks><epigenetic clock><epigenetic molecular clocks><experience><functional ability><functional capacity><healthspan><healthy life span><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><innovate><innovation><innovative><insight><intervention effect><life span><lifespan><long-term followup><long-term study><longitudinal outcome studies><longitudinal research study><methylation clock><mortality><neurocognitive test><novel><older adult><older adulthood><older groups><older individuals><older person><pace of aging><pace of biological aging><pathogen><population aging><prevent><preventing><primary degenerative dementia><programs><randomized control trial><randomized trial><rate of aging><rate of biological aging><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><risk-reducing><senile dementia of the Alzheimer type><social><social role><speed of aging><speed of the aging><tool><treatment group><waitlist><young adult><young adult age><young adulthood>

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Alaattin Kaya

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$333,505

FY 2026

Project Title

Understanding of Essential Gene Function in Aging

Grant Number:

5R01AG079944-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

3/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Functional genomic studies have contributed enormously to our understanding of conserved genetic pathways influencing aging in evolutionarily divergent organisms. The use of high throughput machinery and the application of skilled manpower along with screening systematic gene knock-o...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><Address><Affect><Aging><Bioavailability><Biogenesis><Biological Availability><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Candidate Disease Gene><Candidate Gene><Cell Aging><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Complex><Data><Development><Epistasis><Epistatic Deviation><Essential Genes><Eukaryota><Eukaryote><Evolution><Gene Copy Number><Gene Dosage><Gene Expression><Gene Transcription><GeneHomolog><Genes><Genetic><Genetic Epistasis><Genetic Transcription><Geroscience><Goals><Homolog><Homologous Gene><Homologue><Human><Human Resources><Increase lifespan><Interaction Deviation><Invertebrata><Invertebrates><Length of Life><Life><Longevity><Longevity Pathway><Macropain><Macroxyproteinase><Manpower><Maps><Measurement><Mediating><Modern Man><Molecular><Multicatalytic Proteinase><Nematoda><Nematodes><Organism><Origin of Life><Ortholog><Orthologous Gene><Pathway interactions><Pattern><Persons><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phenotype><Physiologic Availability><Play><Post-Transcriptional Gene Silencing><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteosome><RNA Expression><RNA Interference><RNA Seq><RNA Silencing><RNA sequencing><RNAi><RNAseq><Regulation><Replicative Senescence><Role><Sequence-Specific Posttranscriptional Gene Silencing><Signal Pathway><Source><Subcellular Process><System><Testing><Transcription><Translations><Validation><Yeasts><abnormal protein homeostasis><abnormal proteostasis><age associated><age associated alterations><age associated changes><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related pathways><age specific><age specific alterations><age specific changes><aging associated alterations><aging associated changes><aging associated mechanism><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging gene><aging induced alterations><aging induced changes><aging mechanism><aging pathway><aging process><aging related alterations><aging related changes><aging related mechanism><aging related pathways><aging specific alterations><aging specific changes><alterations with age><biological mechanism of age><biological pathways of age><boost longevity><changes with age><defective proteostasis><design><designing><developmental><dosage><elongating the lifespan><enhance longevity><epistatic interaction><epistatic relationship><experiment><experimental research><experimental study><experiments><extend life span><extend lifespan><extend longevity><foster longevity><functional genomics><functional group><gene conservation><gene function><gene testing><gene x gene interaction><gene-based testing><genetic epistases><genetic testing><genome scale><genome-wide><genomewide><geroscientific><healthspan><healthy aging><healthy human aging><healthy life span><improve lifespan><improve longevity><insight><knockout gene><late in life><late life><life span><lifespan><lifespan extension><living system><longevity gene><mRNA Expression><mRNA Surveillance><mechanism regulating aging><mechanisms involved in aging><molecular phenotype><multicatalytic endopeptidase complex><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><overexpress><overexpression><pace of aging><pace of biological aging><pathway><pathway involved in aging><personnel><pharmaceutical><prolong lifespan><prolong longevity><promote lifespan><promote longevity><protein homeostasis><protein homeostasis decline><protein homeostasis deficiency><protein homeostasis dysfunction><protein homeostasis failure><protein homeostasis loss><proteostasis><proteostasis decline><proteostasis defect><proteostasis deficiency><proteostasis dysfunction><proteostasis dysregulation><proteostasis failure><proteostasis impairment><proteostasis loss><rate of aging><rate of biological aging><replicative aging><roundworm><screening><screenings><skills><social role><speed of aging><speed of the aging><stem><support longevity><tool><transcriptome sequencing><transcriptomic sequencing><translation><validations>

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Kristopher Burkewitz

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$324,925

FY 2026

Project Title

Targeting ER-mitochondrial calcium signaling to promote healthier aging

Grant Number:

5R01AG073354-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract Fundamental gaps remain in our understanding of the cell biological mechanisms that drive mitochondrial decline and associated age-related diseases. Organelles like the mitochondria and endoplasmic reticulum (ER) are physically and functionally linked, in part via sites of m...

Research Terms

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ULRICH E MAYR

UNIVERSITY OF OREGON, EUGENE, OR

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$303,163

FY 2026

Project Title

The role of conjunctive representations in cognitive control, learning, and aging

Grant Number:

1R01AG092600-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract Goal-directed thinking and acting relies on a cognitive system that maintains stable thoughts and action plans in the face of interference but can also flexibly change course when necessary. These opposing qualities are attributed to cognitive control functions, and combined...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Aging><Animal Model><Animal Models and Related Studies><Behavior><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Complex><Conflict><Conflict (Psychology)><Cost efficiency><Diagnostic><Dimensions><Disturbance in cognition><EEG><Electroencephalogram><Electroencephalography><Equilibrium><Event><Foundations><Goals><Human><Impaired cognition><Individual><Individual Differences><Knowledge><Learning><Learning Skill><Link><Mental Health><Mental Hygiene><Methodology><Methods><Modeling><Modern Man><Nervous System Diseases><Nervous System Disorder><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurologic Disorders><Neurological Disorders><Neurosciences><Pattern><Performance><Predisposition><Preparation><Psychological Health><Psychology><Research><Resistance><Role><Scalp><Scalp structure><Shapes><Source><Specific qualifier value><Specified><Stimulus><Sum><Susceptibility><Techniques><Testing><Thinking><Time><Work><adulthood><age associated alterations><age associated changes><age associated difference><age based difference><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age dependent difference><age dependent variation><age difference><age induced alterations><age induced changes><age related alterations><age related changes><age related difference><age related variation><age specific alterations><age specific changes><age specific difference><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><balance><balance function><behavior outcome><behavioral outcome><changes with age><cognitive control><cognitive dysfunction><cognitive function><cognitive loss><cognitive system><conflict resolution><cost><differ by age><difference across age><difference in age><flexibility><flexible><innovate><innovation><innovative><life span><lifespan><mental function><model of animal><neural><neurological disease><novel><older adult><older adulthood><preparations><programs><recruit><resistant><response><social role><temporal measurement><temporal resolution><theories><thoughts><time measurement><variation by age>

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Gen Li

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$298,419

FY 2026

Project Title

Novel Machine Learning Methods for Immunosenescence and Aging Research

Grant Number:

1R01AG097771-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY This proposal aims to develop advanced statistical and computational methods for analyzing immune data to enhance our understanding of the immune system’s role in aging and age-related diseases. Aging is accompanied by significant changes in the immune system, increasing susceptibili...

Research Terms

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Brian J. North

CREIGHTON UNIVERSITY, OMAHA, NE

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$298,275

FY 2026

Project Title

Regulatory Mechanisms Governing BubR1 Protein Stability During Stress and Aging

Grant Number:

5R01AG077574-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract: BubR1 is a key regulator of aging through suppressing cellular senescence and is a critical tumor suppressor through its role in maintaining genome integrity by sustaining fidelity in chromosomal segregation during mitosis through control of the spindle assembly checkpoint. Importantly, Bu...

Research Terms

<APF-1><ATP-Dependent Proteolysis Factor 1><Acetylation><Acetyltransferase><Age><Age related pathologies><Aging><Aneuploid><Aneuploidy><Binding><Biological><Body Tissues><CBP gene><CBP protein><CCND1 Protein><CHEK1><CHEK1 gene><CHK1><CREB-binding protein><CREBBP><CREBBP gene><Cancers><Cell Aging><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cell Signaling><Cell Survival><Cell Viability><Cell-Cycle Checkpoint Kinase><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Cellular Stress><Cellular Stress Response><Checkpoint kinase 1><Cullin Domain Protein><Cullin Family Gene><Cullin Family Protein><Cullin Proteins><Cullins><Cyclin D1><D-Glucose><DNA mutation><Deacetylase><Dextrose><Disease><Disorder><E3 Ligase><E3 Ubiquitin Ligase><Ensure><F Box><F Box Domain><Fibroblasts><G1/S-Specific Cyclin D1><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genome Instability><Genome Stability><Genomic Instability><Genomic Stability><Glucose><Goals><HMG-20><Health><High Mobility Protein 20><Human><In Vitro><Increase lifespan><Intracellular Communication and Signaling><L-Lysine><Link><Lysine><M Phase><Malignant Neoplasms><Malignant Tumor><Mammalia><Mammals><Mediating><Metabolic Protein Degradation><Mice><Mice Mammals><Mitosis><Mitosis Stage><Mitotic><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Mutation><Nutrient><Oncogenesis><PRAD1 Protein><Pathway interactions><Physiologic><Physiological><Post-Translational Regulation><Posttranslational Regulation><Premature Aging><Premature aging syndrome><Protein Acetylation><Protein Turnover><Proteins><Proteome><Proteomics><Proto-Oncogene Proteins c-bcl-1><Regulation><Regulatory Protein Degradation><Replicative Senescence><Role><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Stress><Subcellular Process><Testing><Therapeutic><Tissues><Tumor Cell><Tumor Suppressor Proteins><Ubiquitilation><Ubiquitin><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><accelerated aging><accelerated biological age><accelerated biological aging><age acceleration><age associated decline><age associated disease><age associated disorder><age associated impairment><age associated pathologies><age dependent decline><age dependent disease><age dependent disorder><age dependent impairment><age dependent pathologies><age induced pathologies><age related decline><age related human disease><age-related disease><age-related disorder><age-related impairment><aged animal><aged animals><ages><aging associated><aging associated pathologies><aging delay><aging dependent pathologies><aging induced pathologies><aging pathologies><aging prevention><aging process><aging related><aging related pathologies><animal old age><anti aging><anti geronic><antiaging><attenuate aging><bcl-1 Proto-Oncogene Products><bcl-1 Proto-Oncogene Proteins><bcl1 Proto-Oncogene Proteins><biologic><biological signal transduction><boost longevity><c-bcl-1 Proteins><cancer progression><cell stress><cell-cycle check point kinase><check point kinase 1><chk1 kinase><chk1 protein kinase><cyclin D><decelerate aging><decline with age><delay age related><deprivation><detection of nutrient><druggable target><elderly animal><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><foster longevity><genome integrity><genome mutation><genomic integrity><healthspan><healthy life span><improve lifespan><improve longevity><in vivo Model><life span><lifespan><lifespan extension><malignancy><mouse model><murine model><natural aging><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><normal aging><normative aging><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><nutrient deprivation><nutrient sensing><nutritional deprivation><old animals><pathway><pause aging><perception of nutrients><postpone age related><prevent><prevent age related><prevent aging><preventing><prolong lifespan><prolong longevity><promote lifespan><promote longevity><protein degradation><replicative aging><response><retards aging><segregation><senescence><senescent><slow aging><slow down aging><slow the rate of aging><social role><support longevity><suppress aging><tumor progression><tumor suppressor><tumorigenesis><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase>

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Allison E Aiello

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$279,470

FY 2026

Project Title

Testing effects of cash transfers on biological aging and risk for Alzheimer's Disease

Grant Number:

3R01AG087158-03S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Alzheimer's Disease (AD) and AD-Related Disorders (AD/ADRD) are significantly increasing in resource-limited areas, where improved nutrition and decreased infectious disease mortality are enabling population aging. Simultaneously, enduring elevated levels of early-life adversity and adult hardship a...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><Acceleration><Activities of Daily Living><Activities of everyday life><Address><Adult><Adult Human><Africa><Africa South of the Sahara><Age><Aging><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Assay><Bioassay><Biological><Biological Aging><Biological Assay><Blood><Blood Reticuloendothelial System><Cell Body><Cells><Chronic Disease><Chronic Illness><Cognition><Cognitive aging><Communicable Diseases><Consumption><Control Groups><DNA Methylation><Data><Dementia><Development><Disease><Disease Outcome><Disorder><Dryness><EOAD><Early Onset Alzheimer Disease><Economics><Exhibits><Generations><Government><GrimAge clock><Hannum clock><Health><Health Benefit><Horvath clock><Household><Hypertension><Immune><Immunes><Immunity><Individual><Infectious Diseases><Infectious Disorder><Influentials><International><Intervention><Knowledge><Life><Link><Long-term Follow-up><Longitudinal Studies><Longitudinal Surveys><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Malawi><Measurement><Measures><Methods><Neurocognitive><Nutrition><Nyasaland><Obesity><Older Population><Participant><Pattern><PhenoAge clocks><Phenotype><Population><Prevalence><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Public Health><Randomization trial><Randomized, Controlled Trials><Research><Research Specimen><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Risk Factors><Risk Reduction><Role><Sampling><South Africa><Specimen><Spottings><Sub-Saharan Africa><Subsaharan Africa><Survey Instrument><Surveys><Testing><Time><Underweight><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Waiting Lists><accelerated aging><accelerated biological age><accelerated biological aging><adiposity><adult youth><adulthood><age acceleration><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging associated><aging associated disease><aging associated disorders><aging population><aging related><aging related disease><aging related disorders><alzheimer risk><biologic><biological age><biological process of age><burden of disease><burden of illness><chronic disorder><cognitive assessment><cognitive function><cognitive testing><cohort><corpulence><daily living function><daily living functionality><dementia risk><developmental><disease associated with aging><disease burden><disease of aging><disease risk><disorder of aging><disorder risk><disorders associated with aging><disorders related to aging><early adversity><early childhood adversity><early life adversity><early onset AD><early onset Alzheimer's><economic><epigenetic age clocks><epigenetic clock><epigenetic molecular clocks><experience><functional ability><functional capacity><healthspan><healthy life span><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><innovate><innovation><innovative><insight><intervention effect><life span><lifespan><long-term followup><long-term study><longitudinal outcome studies><longitudinal research study><methylation clock><mortality><neurocognitive test><novel><older adult><older adulthood><older groups><older individuals><older person><pace of aging><pace of biological aging><pathogen><population aging><prevent><preventing><primary degenerative dementia><programs><randomized control trial><randomized trial><rate of aging><rate of biological aging><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><risk-reducing><senile dementia of the Alzheimer type><social><social role><speed of aging><speed of the aging><tool><treatment group><waitlist><young adult><young adult age><young adulthood>

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Daniel Walker Belsky

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$279,470

FY 2026

Project Title

Testing effects of cash transfers on biological aging and risk for Alzheimer's Disease

Grant Number:

3R01AG087158-03S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Alzheimer's Disease (AD) and AD-Related Disorders (AD/ADRD) are significantly increasing in resource-limited areas, where improved nutrition and decreased infectious disease mortality are enabling population aging. Simultaneously, enduring elevated levels of early-life adversity and adult hardship a...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><Acceleration><Activities of Daily Living><Activities of everyday life><Address><Adult><Adult Human><Africa><Africa South of the Sahara><Age><Aging><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Assay><Bioassay><Biological><Biological Aging><Biological Assay><Blood><Blood Reticuloendothelial System><Cell Body><Cells><Chronic Disease><Chronic Illness><Cognition><Cognitive aging><Communicable Diseases><Consumption><Control Groups><DNA Methylation><Data><Dementia><Development><Disease><Disease Outcome><Disorder><Dryness><EOAD><Early Onset Alzheimer Disease><Economics><Exhibits><Generations><Government><GrimAge clock><Hannum clock><Health><Health Benefit><Horvath clock><Household><Hypertension><Immune><Immunes><Immunity><Individual><Infectious Diseases><Infectious Disorder><Influentials><International><Intervention><Knowledge><Life><Link><Long-term Follow-up><Longitudinal Studies><Longitudinal Surveys><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Malawi><Measurement><Measures><Methods><Neurocognitive><Nutrition><Nyasaland><Obesity><Older Population><Participant><Pattern><PhenoAge clocks><Phenotype><Population><Prevalence><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Public Health><Randomization trial><Randomized, Controlled Trials><Research><Research Specimen><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Risk Factors><Risk Reduction><Role><Sampling><South Africa><Specimen><Spottings><Sub-Saharan Africa><Subsaharan Africa><Survey Instrument><Surveys><Testing><Time><Underweight><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Waiting Lists><accelerated aging><accelerated biological age><accelerated biological aging><adiposity><adult youth><adulthood><age acceleration><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging associated><aging associated disease><aging associated disorders><aging population><aging related><aging related disease><aging related disorders><alzheimer risk><biologic><biological age><biological process of age><burden of disease><burden of illness><chronic disorder><cognitive assessment><cognitive function><cognitive testing><cohort><corpulence><daily living function><daily living functionality><dementia risk><developmental><disease associated with aging><disease burden><disease of aging><disease risk><disorder of aging><disorder risk><disorders associated with aging><disorders related to aging><early adversity><early childhood adversity><early life adversity><early onset AD><early onset Alzheimer's><economic><epigenetic age clocks><epigenetic clock><epigenetic molecular clocks><experience><functional ability><functional capacity><healthspan><healthy life span><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><innovate><innovation><innovative><insight><intervention effect><life span><lifespan><long-term followup><long-term study><longitudinal outcome studies><longitudinal research study><methylation clock><mortality><neurocognitive test><novel><older adult><older adulthood><older groups><older individuals><older person><pace of aging><pace of biological aging><pathogen><population aging><prevent><preventing><primary degenerative dementia><programs><randomized control trial><randomized trial><rate of aging><rate of biological aging><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><risk-reducing><senile dementia of the Alzheimer type><social><social role><speed of aging><speed of the aging><tool><treatment group><waitlist><young adult><young adult age><young adulthood>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sudhanshu Handa

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 58/100

Likely hiring

Solid budget

Recent

Active award

$279,470

FY 2026

Project Title

Testing effects of cash transfers on biological aging and risk for Alzheimer's Disease

Grant Number:

3R01AG087158-03S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

2/28/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Alzheimer's Disease (AD) and AD-Related Disorders (AD/ADRD) are significantly increasing in resource-limited areas, where improved nutrition and decreased infectious disease mortality are enabling population aging. Simultaneously, enduring elevated levels of early-life adversity and adult hardship a...

Research Terms

<21+ years old><AD and related dementia><AD dementia><AD related dementia><AD risk><AD risk factor><ADRD><Acceleration><Activities of Daily Living><Activities of everyday life><Address><Adult><Adult Human><Africa><Africa South of the Sahara><Age><Aging><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Alzheimers Dementia><Amentia><Assay><Bioassay><Biological><Biological Aging><Biological Assay><Blood><Blood Reticuloendothelial System><Cell Body><Cells><Chronic Disease><Chronic Illness><Cognition><Cognitive aging><Communicable Diseases><Consumption><Control Groups><DNA Methylation><Data><Dementia><Development><Disease><Disease Outcome><Disorder><Dryness><EOAD><Early Onset Alzheimer Disease><Economics><Exhibits><Generations><Government><GrimAge clock><Hannum clock><Health><Health Benefit><Horvath clock><Household><Hypertension><Immune><Immunes><Immunity><Individual><Infectious Diseases><Infectious Disorder><Influentials><International><Intervention><Knowledge><Life><Link><Long-term Follow-up><Longitudinal Studies><Longitudinal Surveys><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Malawi><Measurement><Measures><Methods><Neurocognitive><Nutrition><Nyasaland><Obesity><Older Population><Participant><Pattern><PhenoAge clocks><Phenotype><Population><Prevalence><Primary Senile Degenerative Dementia><Protocol><Protocols documentation><Public Health><Randomization trial><Randomized, Controlled Trials><Research><Research Specimen><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Risk Factors><Risk Reduction><Role><Sampling><South Africa><Specimen><Spottings><Sub-Saharan Africa><Subsaharan Africa><Survey Instrument><Surveys><Testing><Time><Underweight><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Waiting Lists><accelerated aging><accelerated biological age><accelerated biological aging><adiposity><adult youth><adulthood><age acceleration><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging associated><aging associated disease><aging associated disorders><aging population><aging related><aging related disease><aging related disorders><alzheimer risk><biologic><biological age><biological process of age><burden of disease><burden of illness><chronic disorder><cognitive assessment><cognitive function><cognitive testing><cohort><corpulence><daily living function><daily living functionality><dementia risk><developmental><disease associated with aging><disease burden><disease of aging><disease risk><disorder of aging><disorder risk><disorders associated with aging><disorders related to aging><early adversity><early childhood adversity><early life adversity><early onset AD><early onset Alzheimer's><economic><epigenetic age clocks><epigenetic clock><epigenetic molecular clocks><experience><functional ability><functional capacity><healthspan><healthy life span><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><innovate><innovation><innovative><insight><intervention effect><life span><lifespan><long-term followup><long-term study><longitudinal outcome studies><longitudinal research study><methylation clock><mortality><neurocognitive test><novel><older adult><older adulthood><older groups><older individuals><older person><pace of aging><pace of biological aging><pathogen><population aging><prevent><preventing><primary degenerative dementia><programs><randomized control trial><randomized trial><rate of aging><rate of biological aging><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk factor for dementia><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk for dementia><risk of developing Alzheimer's><risk-reducing><senile dementia of the Alzheimer type><social><social role><speed of aging><speed of the aging><tool><treatment group><waitlist><young adult><young adult age><young adulthood>

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Maria Mavrikaki

BETH ISRAEL DEACONESS MEDICAL CENTER, BOSTON, MA

Good lead · 56/100

Likely hiring

Very recent

Active award

$182,997

FY 2026

Project Title

Molecular mechanisms of aging and accelerated aging in the human brain

Grant Number:

3R01AG079799-03S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2023

End Date:

5/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY. This proposal is in response to PAR-21-038: Stephen I. Katz Early Stage Investigator Research Project Grant. Aging is a major risk factor for the development of cognitive deficits and neurodegenerative diseases. Understanding the exact molecular mechanisms of brain aging and accelerated bra...

Research Terms

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Rinku Sharma

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$170,570

FY 2026

Project Title

Exploring the Molecular Landscape of Lung Health and Aging Through a Multi-Omics Lens

Grant Number:

1K99HL183694-01

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Lung function (LF) decline, a key indicator of respiratory health, is closely linked to age-related diseases, driving up healthcare costs and reducing quality of life. Understanding and mitigating LF decline is therefore essential. Aging, influenced by cellular senescence, i...

Research Terms

<0-11 years old><21+ years old><Acceleration><Address><Adult><Adult Human><Advisory Committees><Age><Aging><Airway health><Algorithms><Asthma><Automobile Driving><Body System><Bronchial Asthma><COPD><Cardiovascular Diseases><Categories><Cell Aging><Cell Senescence><Cellular Aging><Cellular Senescence><Child><Child Youth><Children (0-21)><Chronic><Chronic Disease><Chronic Illness><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Chronology><Clinical><Communication><Communities><Complex><Computerized Medical Record><DNA Methylation><Data><Data Bases><Data Scientist><Databases><Development><Diathesis><Disease><Disease Progression><Disease susceptibility><Disorder><Documentation><Drug Interactions><Drug Side Effects><Drug Targeting><Drugs><Electronic Medical Record><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><FEV1><FEV1%VC><Forced Expiratory Volume 1 Test><Forced Expiratory Volume in 1 Second><Foundations><Future><Genes><Graph><GrimAge clock><Hannum clock><Health><Health Care Costs><Health Costs><Health Status><Horvath clock><Hospitals><Impairment><Individual><Inflammation><Infrastructure><Investigation><Investigators><Knowledge><Level of Health><Link><Lung><Lung Diseases><Lung Respiratory System><Massachusetts><Measures><Medication><Medicine><Mentors><Mentorship><Methodology><MicroRNAs><Molecular><Molecular Fingerprinting><Molecular Profiling><Multiomic Data><NHLBI><National Heart, Lung, and Blood Institute><Organ System><Outcome><Oxidative Stress><PFT/FEV1><Pattern><Pharmaceutical Preparations><PhenoAge clocks><Phenotype><Play><Position><Positioning Attribute><Predicting Risk><Preventative strategy><Prevention strategy><Preventive strategy><Process><Proteins><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Function Test/Forced Expiratory Volume 1><QOL><Quality of life><RNA Seq><RNA sequencing><RNAseq><Replicative Senescence><Research><Research Design><Research Ethics><Research Personnel><Research Resources><Researchers><Resources><Risk><Role><Shapes><Spirometry><Study Type><Task Forces><Temporal trend><Time trend><Training><Trends over time><Woman><accelerated aging><accelerated biological age><accelerated biological aging><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><adulthood><advisory team><age acceleration><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><ages><aging biological marker><aging biomarker><aging induced epigenetic change><aging marker><aging process><aging-associated epigenetic change><aging-related epigenetic change><bio-informatics resource><biobank><bioinformatics resource><biomarker identification><biorepository><cardiovascular disorder><career><chronic disorder><chronic obstructive pulmonary disorder><cohort><compound repositioning><compound repurposing><data base><developmental><disease of the lung><disease risk><disorder of the lung><disorder risk><driving><drug repositioning><drug repurposing><drug/agent><electronic data><epigenetic age clocks><epigenetic aging><epigenetic clock><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic molecular clocks><epigenetic regulation of aging><epigenetically><experience><faster epigenetic aging><faster rates of epigenetic aging><forecasting risk><gene product><health level><identification of biomarkers><identification of new biomarkers><improved><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><individual heterogeneity><individual variability><individual variation><individualized prevention><insight><kids><knowledge graph><lens><lenses><liability to disease><lung disorder><lung function><lung function decline><lung health><marker identification><medical college><medical schools><metabolism measurement><metabolomics><metabonomics><methylation clock><miRNA><molecular profile><molecular signature><mortality><multiomics><multiple omic data><multiple omics><new therapeutic uses for existing drugs><new use of drug><new uses for an approved drug><new uses for existing drugs><pace of aging><pace of biological aging><panomics><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><personalized prevention><pharmacological repurposing><precision prevention><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><pulmonary function><pulmonary function decline><pulmonary health><rapid epigenetic aging><rate of aging><rate of biological aging><replicative aging><repositioning approved drugs><repositioning existing drugs><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><respiratory><respiratory health><risk prediction><risk predictions><school of medicine><skills><social role><speed of aging><speed of the aging><study design><therapeutic repositioning><therapeutic repurposing><therapeutic target><transcriptome sequencing><transcriptomic sequencing><treatment strategy><youngster>

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Cristina A. F. Román

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$140,808

FY 2026

Project Title

Healthcare Factors and Cardiovascular Risk Influences on Accelerated Brain Aging and Disability in Hispanic Persons with Multiple Sclerosis

Grant Number:

5K23MD019232-04

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/23/2023

End Date:

3/31/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This is a mixed methods study examining healthcare factors, medical comorbidities [i.e., cardiovascular risk factors (CRF)], and accelerated brain aging in Hispanic persons with multiple sclerosis (H-pwMS). This Career Development Award (CDA) will provide the necessary support for Dr. Cristina Román...

Research Terms

<21+ years old><Acceleration><Adult><Adult Human><Age><Aging><Amentia><Applications Grants><Biological><Biological Markers><Brain><Brain Nervous System><Brain imaging><C 2a><C2a><California><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Chronology><Clinical><Communities><Critical Care><Data><Decrease health disparities><Dementia><Development><Disability Assessment><Disability Determination><Disability Evaluation><Disease><Disease Progression><Disorder><Disparities><Disparity><Doctor of Philosophy><Early Intervention><Encephalon><Ensure><Espanol><Foundations><Goals><Grant Proposals><Groups at risk><Health><Health Care><Health disparity mitigation><Health disparity reduction><Heart Vascular><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Individual><Infrastructure><Intervention><Investigation><Investigators><K-Awards><K-Series Research Career Programs><Knowledge><Lived experience><Lived experiences><Longitudinal Studies><Longitudinal Surveys><Lower health disparities><MR Imaging><MR Tomography><MRI><MRIs><MS patient><Machine Learning><Magnetic Resonance Imaging><Manuscripts><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentorship><Methods><Mission><Mitigate health disparities><Modeling><NCMHD><NIH><NIMHD><NMR Imaging><NMR Tomography><National Center on Minority Health and Health Disparities><National Institute of Minority Health and Health Disparities><National Institute on Minority Health and Health Disparities><National Institutes of Health><Nerve Degeneration><Nervous System Diseases><Nervous System Disorder><Neurologic><Neurologic Disorders><Neurological><Neurological Disorders><Neuron Degeneration><Neuropsychologies><Neuropsychology><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Nuclear Magnetic Resonance Imaging><Outcome><Participant><People at risk><Persons><Persons at risk><Ph.D.><PhD><Population><Populations at Risk><Prognosis><Reduce health disparities><Research><Research Career Program><Research Personnel><Research Resources><Researchers><Resources><Risk><Risk Factors><Sampling><Scientific Advances and Accomplishments><Spanish><Stress><Training><United States National Institutes of Health><Universities><Work><Writing><Zeugmatography><access to health care><accessibility of health care><accessibility to health care><adulthood><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age related alterations><age related changes><age specific alterations><age specific changes><aged brain><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><bio-markers><biologic><biologic marker><biomarker><brain health><brain visualization><brain volume><cardiovascular risk><cardiovascular risk factor><career><changes with age><circulatory system><co-morbid><co-morbidity><comorbidity><complement 2a><complement C2a><complement C2a fragment><design><designing><developmental><disability><disparity in health><effective intervention><experience><functional outcomes><health care access><health care availability><health care management><health care quality><health care service access><health care service availability><health disparity><health management><high risk><improved><long-term study><longitudinal outcome studies><longitudinal research study><machine based learning><medical college><medical schools><mortality><multiple sclerosis patient><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neurological disease><neuronal degeneration><neuropsychologic><offspring><patients with MS><patients with multiple sclerosis><people with Multiple sclerosis><premature><prematurity><profound disability><recruit><school of medicine><scientific accomplishments><scientific advances><serious disability><severe disability><skills><stem><virtual>

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Daniel Callow

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Good lead · 56/100

Training-friendly

Very recent

Active award

Career award

$130,139

FY 2026

Project Title

Insights into Cognitive Resilience: Sleep, Physical Activity, and Neuroimaging Biomarkers in Aging and Preclinical Alzheimer's Disease

Grant Number:

5K01AG092954-02

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/15/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This Mentored Patient-Oriented Research Career Development Award (K01) application aims to equip the candidate with the skills to establish an independent research program identifying modifiable lifestyle factors to enhance cognitive resilience in aging and Alzheimer's disease-related dementias (ADR...

Research Terms

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Rebecca G Reed

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 56/100

Likely hiring

Very recent

Active award

$111,298

FY 2026

Project Title

Administrative Supplement: Accelerated Epigenetic Aging as a Mechanism in Lifespan Socioeconomic Effects on Midlife Cognitive Decline

Grant Number:

3R01AG086346-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Progressive cognitive decline including Alzheimer’s Disease and its related dementias (ADRD) does not suddenly occur in later life; it emerges over time, influenced by many mechanisms across the lifespan. Evidence links individual- and, more recently, community-level socioeconomic co...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><ADRD><Address><Administrative Supplement><Adult><Adult Human><Affect><Age><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Amentia><Attention><Behavior><Biological><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Causality><Childhood><Chronology><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><DNA Methylation><Data><Dementia><Development><Disturbance in cognition><Early Diagnosis><Economic Conditions><Economic Income><Economical Conditions><Economical Income><Education><Educational aspects><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epigenetic age><Etiology><Exposure to><Female><Future><Health><Health Inequity><Impaired cognition><Income><Individual><Inequalities in Health><Inequities in Health><Intervention><Knowledge><Life><Link><Mediating><Modeling><Molecular><Neuropsychologies><Neuropsychology><Occupational><Pathway interactions><Pattern><Persons><Phenotype><Prevention><Public Health><Research><Research Resources><Resources><Risk><Risk Reduction><Role><Sampling><Shapes><Social Mobility><Socioeconomic Factors><Specific qualifier value><Specified><Stress><Testing><Time><accelerated aging><accelerated biological age><accelerated biological aging><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><accumulated exposure><accumulated long-term exposure><adulthood><age acceleration><age associated><age correlated><age dependent><age linked><age related><age related pathways><age specific><ages><aggregate exposure><aging associated mechanism><aging induced epigenetic change><aging mechanism><aging pathway><aging related mechanism><aging related pathways><aging-associated epigenetic change><aging-related epigenetic change><biologic><biological age><biological mechanism of age><biological pathways of age><causation><cognitive change><cognitive dysfunction><cognitive function><cognitive loss><cohort><community safety><cumulative exposure><cumulative life exposure><cumulative long-term exposure><dementia risk><develop therapy><developmental><disease causation><early detection><epigenetic aging><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic regulation of aging><epigenetically><faster epigenetic aging><faster rates of epigenetic aging><health inequalities><incomes><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><innovate><innovation><innovative><insight><intervention development><later in life><later life><life span><life-course exposure><lifelong exposure><lifespan><lifespan exposure><lifetime exposure><mechanism regulating aging><mechanisms involved in aging><mid life><mid-life><middle age><middle aged><midlife><neighborhood safety><neuropsychologic><pathway><pathway involved in aging><pediatric><rapid epigenetic aging><recruit><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk factor for dementia><risk for dementia><risk-reducing><social><social role><socio-economic><socio-economic factors><socio-economically><socioeconomically><socioeconomics><therapy development><totality of exposures><treatment development><treatment strategy><♀>

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Kathryn D Meyer

DUKE UNIVERSITY, DURHAM, NC

Good lead · 52/100

Likely hiring

Solid budget

Active award

$493,972

FY 2026

Project Title

Cell Type-Specific Epitranscriptomic Regulation in the Brain in Aging and Alzheimer's Disease

Grant Number:

1R01AG093664-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Alzheimer’s Disease (AD) is a progressive neurodegenerative disorder which currently affects nearly 7 million people nationwide. Although the causes of AD are still not completely understood, it is clear that a combination of genetic, environmental, and age-related factors contribute...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD brain><AD dementia><AD model><AD patients><Adenosine><Affect><Age><Aged 65 and Over><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease patient><Alzheimer's patient><Alzheimers Dementia><Animals><Brain><Brain Nervous System><Causality><Cell Body><Cells><Chemicals><Chromatin><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Complex><DNA><Data Set><Defect><Degenerative Neurologic Disorders><Deoxyribonucleic Acid><Development><Disease><Disease Progression><Disorder><Disturbance in cognition><Encephalon><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic><Genetic Transcription><Histones><Human><Impaired cognition><Individual><Investigation><Knowledge><Learning><Link><Maps><Mediating><Memory><Messenger RNA><Methylation><Mice><Mice Mammals><Modern Man><Modification><Molecular><Murine><Mus><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural Development><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Non-Polyadenylated RNA><Pathogenesis><Pathogenicity><Persons><Play><Prevalence><Primary Senile Degenerative Dementia><Proteins><RNA><RNA Expression><RNA Gene Products><RNA Processing><RNA Splicing><RNA and protein interaction><RNA methylation><RNA-Protein Interaction><Reader><Regulation><Regulator Genes><Regulatory Pathway><Research><Resolution><Ribonucleic Acid><Rodent><Rodentia><Rodents Mammals><Role><Splicing><Synaptic plasticity><Time><Transcription><Transcriptional Regulatory Elements><Translations><United States><Wild Type Mouse><Work><above age 65><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age associated alterations><age associated changes><age associated effects><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age effect><age induced alterations><age induced changes><age linked><age of 65 years onward><age related><age related alterations><age related changes><age related effects><age specific><age specific alterations><age specific changes><aged 65 and greater><aged 65+><aged brain><aged ≥65><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><alzheimer model><brain cell><brain tissue><causation><cell type><changes with age><cognitive dysfunction><cognitive loss><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><disease causation><environmental risk><epigenetic regulation><epigenetically><epitranscriptomics><genetic trans acting element><healthy aging><healthy human aging><human old age (65+)><impact of age><influence of age><insight><mRNA><mouse model><murine model><nerve cell death><nerve cell loss><neurodegenerative illness><neurodevelopment><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal cell death><neuronal cell loss><neuronal death><neuronal loss><novel><over 65 years><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><posttranscriptional><primary degenerative dementia><regulatory gene><resolutions><senile dementia of the Alzheimer type><social role><trans acting element><translation><virtual><wildtype mouse><≥65 years>

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David George Ashbrook

UNIVERSITY OF TENNESSEE HEALTH SCI CTR, MEMPHIS, TN

Good lead · 52/100

Likely hiring

Solid budget

Active award

$484,593

FY 2026

Project Title

The interaction effects of genetic variants, age, diet, sex and mitochondrial copy number on Alzheimer's disease, aging-phenotypes and longevity

Grant Number:

5R01AG075813-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

As the average age of the population increases, understanding the biology of longevity and diseases of aging is increasingly important. The key role of mitochondria in Alzheimer’s disease (AD) and pathogenic aging has been established in studies across species and mechanistically validated using gen...

Research Terms

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Kristopher Burkewitz

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 52/100

Likely hiring

Solid budget

Active award

$482,800

FY 2026

Project Title

Understanding sphingolipid-dependent remodeling of mitochondria in aging cells

Grant Number:

1R01AG092718-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary One of the hallmarks of aging is a decline in the function of mitochondria, which is associated with changes in mitochondria morphology as cells age. However, mechanisms contributing to mitochondrial dysfunction in aging cells are not well understood. We have determined that interven...

Research Terms

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Jason A MacGurn

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 52/100

Likely hiring

Solid budget

Active award

$482,800

FY 2026

Project Title

Understanding sphingolipid-dependent remodeling of mitochondria in aging cells

Grant Number:

1R01AG092718-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary One of the hallmarks of aging is a decline in the function of mitochondria, which is associated with changes in mitochondria morphology as cells age. However, mechanisms contributing to mitochondrial dysfunction in aging cells are not well understood. We have determined that interven...

Research Terms

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MAULIK R PATEL

VANDERBILT UNIVERSITY, Nashville, TN

Good lead · 52/100

Likely hiring

Solid budget

Active award

$482,800

FY 2026

Project Title

Understanding sphingolipid-dependent remodeling of mitochondria in aging cells

Grant Number:

1R01AG092718-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2031

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary One of the hallmarks of aging is a decline in the function of mitochondria, which is associated with changes in mitochondria morphology as cells age. However, mechanisms contributing to mitochondrial dysfunction in aging cells are not well understood. We have determined that interven...

Research Terms

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Russell T Hepple

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 52/100

Likely hiring

Solid budget

Active award

$472,352

FY 2026

Project Title

Linking kynurenine accumulation and the AHR pathway to exacerbated aging

Grant Number:

5R01AG076490-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Physical frailty (hereafter simplified to “frailty”) refers to a clinical state associated with an individual’s increased risk of dependence or mortality when exposed to a stressor and has emerged as a major predictor of poor health outcomes in the elderly. Unfortunately, th...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><3-hydroxykynurenine transaminase><AH Receptors><Acceleration><Active Oxygen><Aging><Agonist><Aryl Hydrocarbon Receptor><Atrophic><Atrophy><Attenuated><Basal Transcription Factor><Basal transcription factor genes><Binding><Biotransformation><Blood><Blood Reticuloendothelial System><Body Tissues><Body Weight><Catabolism><Cell Body><Cells><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Research><Clinical Study><Coupled><Cytochrome P-450><Cytochrome P-450 Enzyme System><Cytochrome P450><Cytochrome P450 Family Gene><Cytosol><Data><Denervation><Dependence><Deterioration><Diet><Dimensions><Dioxin Receptors><Disease><Disorder><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Dysfunction><Elderly><Enzyme Gene><Enzymes><Exposure to><FDA approved><Foundations><Frail Elderly><Frail Elders><Frail Older Adults><Frail Seniors><Functional disorder><Future><GOT2><GOT2 gene><General Transcription Factor Gene><General Transcription Factors><Genetic Models><Goals><Grip strength><Hand Strength><Health><Human><Impairment><In Situ><Individual><Intermediary Metabolism><Isoforms><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Kynurenic Acid><Kynurenine><Kynurenine-oxoglutarate aminotransferase><L-Tryptophan><Learning><Levotryptophan><Life Expectancy><Ligands><Link><Metabolic><Metabolic Biotransformation><Metabolic Drug Detoxications><Metabolic Processes><Metabolism><Metabolism of Toxic Agents><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Modernization><Molecular Interaction><Morbidity><Motor><Motor Cell><Motor Neurons><Murine><Mus><Muscle><Muscle Atrophy><Muscle Fibers><Muscle Tissue><Muscular Atrophy><Myoneural Junction><Myotubes><Neuromuscular Junction><Nuclear Translocator><Null Mouse><Outcome><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxygen Radicals><P450><Pathway interactions><Phenotype><Physical Function><Physiologic><Physiological><Physiopathology><Polyaromatic Hydrocarbon Receptors><Predisposition><Pro-Oxidants><Protein Cleavage><Protein Isoforms><Proteolysis><QOL><Quality of life><Reactive Oxygen Species><Receptor Activation><Reporting><Research><Resveratrol><Rhabdomyocyte><Risk><Rodent><Rodentia><Rodents Mammals><Role><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Susceptibility><TCDD Receptors><Testing><Tissues><Transcript><Transcription Factor Proto-Oncogene><Transcription factor genes><Tryptophan><Tryptophan Metabolism><Tryptophan Metabolism Pathway><Voluntary Muscle><Work><accelerated aging><accelerated biological age><accelerated biological aging><advanced age><age acceleration><age associated decline><age dependent decline><age related decline><aged muscle><aging of muscle><ahr ligand><antagonism><antagonist><aryl hydrocarbon receptor ligand><attenuate><attenuates><chronic disorder><decline with age><detoxification><diets><drug detection><drug testing><epidemiology research study><epidemiology study><epidemiology survey><exercise training><frail older adult><frailty><geriatric><hallmarks of aging><healthspan><healthy aging><healthy human aging><healthy life span><indexing><inhibitor><knock-down><knockdown><kynurenine aminotransferase><kynurenine-oxoglutarate transaminase><loss of function><mitochondrial><mitochondrial dysfunction><mortality><motoneuron><muscle aging><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle wasting><muscular><natural aging><nerve cell death><nerve cell loss><neuromuscular><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal cell death><neuronal cell loss><neuronal death><neuronal loss><neuroprotection><neuroprotective><normal aging><normative aging><older adult><older adulthood><pathophysiology><pathway><pillars of aging><poor health outcome><reduced health outcome><sarcopenia><sarcopenic><senior citizen><skeletal muscle atrophy><skeletal muscle breakdown><skeletal muscle loss><skeletal muscle protein loss><skeletal muscle wasting><social role><stressor><therapeutic target><transcription factor><walking pace><walking speed><worse health outcome>

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Terence E Ryan

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 52/100

Likely hiring

Solid budget

Active award

$472,352

FY 2026

Project Title

Linking kynurenine accumulation and the AHR pathway to exacerbated aging

Grant Number:

5R01AG076490-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Physical frailty (hereafter simplified to “frailty”) refers to a clinical state associated with an individual’s increased risk of dependence or mortality when exposed to a stressor and has emerged as a major predictor of poor health outcomes in the elderly. Unfortunately, th...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><3-hydroxykynurenine transaminase><AH Receptors><Acceleration><Active Oxygen><Aging><Agonist><Aryl Hydrocarbon Receptor><Atrophic><Atrophy><Attenuated><Basal Transcription Factor><Basal transcription factor genes><Binding><Biotransformation><Blood><Blood Reticuloendothelial System><Body Tissues><Body Weight><Catabolism><Cell Body><Cells><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Research><Clinical Study><Coupled><Cytochrome P-450><Cytochrome P-450 Enzyme System><Cytochrome P450><Cytochrome P450 Family Gene><Cytosol><Data><Denervation><Dependence><Deterioration><Diet><Dimensions><Dioxin Receptors><Disease><Disorder><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Dysfunction><Elderly><Enzyme Gene><Enzymes><Exposure to><FDA approved><Foundations><Frail Elderly><Frail Elders><Frail Older Adults><Frail Seniors><Functional disorder><Future><GOT2><GOT2 gene><General Transcription Factor Gene><General Transcription Factors><Genetic Models><Goals><Grip strength><Hand Strength><Health><Human><Impairment><In Situ><Individual><Intermediary Metabolism><Isoforms><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Kynurenic Acid><Kynurenine><Kynurenine-oxoglutarate aminotransferase><L-Tryptophan><Learning><Levotryptophan><Life Expectancy><Ligands><Link><Metabolic><Metabolic Biotransformation><Metabolic Drug Detoxications><Metabolic Processes><Metabolism><Metabolism of Toxic Agents><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Modernization><Molecular Interaction><Morbidity><Motor><Motor Cell><Motor Neurons><Murine><Mus><Muscle><Muscle Atrophy><Muscle Fibers><Muscle Tissue><Muscular Atrophy><Myoneural Junction><Myotubes><Neuromuscular Junction><Nuclear Translocator><Null Mouse><Outcome><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxygen Radicals><P450><Pathway interactions><Phenotype><Physical Function><Physiologic><Physiological><Physiopathology><Polyaromatic Hydrocarbon Receptors><Predisposition><Pro-Oxidants><Protein Cleavage><Protein Isoforms><Proteolysis><QOL><Quality of life><Reactive Oxygen Species><Receptor Activation><Reporting><Research><Resveratrol><Rhabdomyocyte><Risk><Rodent><Rodentia><Rodents Mammals><Role><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Susceptibility><TCDD Receptors><Testing><Tissues><Transcript><Transcription Factor Proto-Oncogene><Transcription factor genes><Tryptophan><Tryptophan Metabolism><Tryptophan Metabolism Pathway><Voluntary Muscle><Work><accelerated aging><accelerated biological age><accelerated biological aging><advanced age><age acceleration><age associated decline><age dependent decline><age related decline><aged muscle><aging of muscle><ahr ligand><antagonism><antagonist><aryl hydrocarbon receptor ligand><attenuate><attenuates><chronic disorder><decline with age><detoxification><diets><drug detection><drug testing><epidemiology research study><epidemiology study><epidemiology survey><exercise training><frail older adult><frailty><geriatric><hallmarks of aging><healthspan><healthy aging><healthy human aging><healthy life span><indexing><inhibitor><knock-down><knockdown><kynurenine aminotransferase><kynurenine-oxoglutarate transaminase><loss of function><mitochondrial><mitochondrial dysfunction><mortality><motoneuron><muscle aging><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle wasting><muscular><natural aging><nerve cell death><nerve cell loss><neuromuscular><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal cell death><neuronal cell loss><neuronal death><neuronal loss><neuroprotection><neuroprotective><normal aging><normative aging><older adult><older adulthood><pathophysiology><pathway><pillars of aging><poor health outcome><reduced health outcome><sarcopenia><sarcopenic><senior citizen><skeletal muscle atrophy><skeletal muscle breakdown><skeletal muscle loss><skeletal muscle protein loss><skeletal muscle wasting><social role><stressor><therapeutic target><transcription factor><walking pace><walking speed><worse health outcome>

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Anthony John Donato

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 52/100

Likely hiring

Solid budget

Active award

$459,678

FY 2026

Project Title

Integrative Mechanisms of Vascular Aging

Grant Number:

5R01AG077751-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Arterial aging is characterized by diminished endothelium dependent dilation (EDD) and large artery stiffening. The endothelium is a critical modulator of arterial function participating in the control of vascular tone, nitric oxide production and bioavailability, large artery stiffening, inflammati...

Research Terms

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Lisa A Lesniewski

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 52/100

Likely hiring

Solid budget

Active award

$459,678

FY 2026

Project Title

Integrative Mechanisms of Vascular Aging

Grant Number:

5R01AG077751-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Arterial aging is characterized by diminished endothelium dependent dilation (EDD) and large artery stiffening. The endothelium is a critical modulator of arterial function participating in the control of vascular tone, nitric oxide production and bioavailability, large artery stiffening, inflammati...

Research Terms

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Adam Hughes

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 52/100

Likely hiring

Solid budget

Active award

$448,567

FY 2026

Project Title

Endolysosomal Regulation of Amino Acid Homeostasis in Aging

Grant Number:

5R01AG061376-08

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2018

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Organelle deterioration is a common feature of aging, and contributes to a number of age-related diseases. A major interest of my lab is to understand how organelles are functionally interconnected within cells, and uncover mechanisms by which organelle dysfunction perturbs cellular ...

Research Terms

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NAM V VO

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$441,701

FY 2026

Project Title

Mechanisms of Cellular Senescence Driving Intervertebral Disc Aging through Local Cell Autonomous and Systemic Non-Cell Autonomous Processes

Grant Number:

5R01AG081293-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project summary Intervertebral disc degeneration (IDD) underlies many spinal disorders resulting in debilitating back pain, disability, and tremendous economic loss. Aging is the greatest risk factor for IDD and yet the biology of disc aging is still poorly understood. Our prior research demonstrat...

Research Terms

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Zhenqiang Yao

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 52/100

Likely hiring

Solid budget

Active award

$415,033

FY 2026

Project Title

Role of Macrophage in Osteoimmunology with Aging

Grant Number:

5R01AG076731-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

1/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract T helper cells (Th1 and Th17) play an important role in bone homeostasis through regulating osteoclast (OC) formation in autoimmune diseases and OVX-induced osteoporosis. However, how these T cells interactions with bone cells disrupt bone homeostasis during aging to cause b...

Research Terms

<AVP, Type II><Adaptor Protein><Adaptor Protein Gene><Adaptor Signaling Protein><Adaptor Signaling Protein Gene><Age><Age-Associated Osteoporosis><Age-Related Bone Loss><Age-Related Osteoporosis><Aging><Antiviral Protein, Type II><Attenuated><Autoimmune Diseases><Autoregulation><Binding><Biological><Bisphosphonates><Bone Formation><Bone Formation Inhibition><Bone Formation Stimulation><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Resorption><Bone Resorption Inhibition><Bone-Derived Transforming Growth Factor><CD119><CD119 Antigen><CD11b><CD183><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD40 Receptor-Associated Factor 1><CD40bp Protein><CDw119 antigen><CKR-L2><CMKAR3><CR3A><CRAF1 Protein><CRE Recombinase><CXCR3><CXCR3 gene><Cell Aging><Cell Body><Cell Communication><Cell Function><Cell Interaction><Cell Physiology><Cell Process><Cell Senescence><Cell surface><Cell-to-Cell Interaction><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Chemicals><Chemokine (C-X-C Motif) Receptor 3><Chemotactic Cytokines><Chronic><Co-Stimulator><Costimulator><Coupled><Edodekin Alfa><Enterobacteria phage P1 Cre recombinase><Epidermal Thymocyte Activating Factor><FDA approved><G Protein-Coupled Receptor 9><GPR9><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Homeostasis><Homologous Chemotactic Cytokines><Hydroxychlorochin><Hydroxychloroquine><IFN-Gamma><IFN-g><IFN-gamma receptor 1><IFN-gammaR><IFN-γ><IFN-γR><IFNG><IFNGR><IFNGR1><IFNGR1 gene><IFNγ><IL-12><IL-2><IL12><IL2 Protein><IP10><IP10 Receptor><IP10-Mig receptor><IP10-R><ITGAM><ITGAM gene><Immune><Immune Interferon><Immunes><In Vitro><Inducer Cells><Inducer T-Lymphocytes><Inflammaging><Inflammation><Inflammatory><Integrin beta Chains><Integrin beta Subunits><Integrin β Chains><Integrin β Subunits><Intercrines><Interferon Gamma><Interferon Gamma Receptor-1><Interferon Type II><Interferon-Gamma Receptor 1><Interleukin 2><Interleukin 2 Precursor><Interleukin II><Interleukin-12><Interleukin-2><Interleukine 2><Interleukine 2 Precursor><Interleukine II><Knock-out><Knockout><LAP-1 Protein><Legal patent><Link><Lymphocyte Mitogenic Factor><MAC1A><MO1A><Macrophage><Maps><Mediating><Membrane><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mice><Mice Mammals><Mig Receptor><Mig-R><MigR><Milk Growth Factor><Mitogenic Factor><Modeling><Molecular><Molecular Interaction><Murine><Mus><Mφ><NKSF><Natural Killer Cell Stimulatory Factor><OPGL><Osteoblasts><Osteoclastic Bone Loss><Osteoclasts><Osteogenesis><Osteoporosis><Osteoporotic><Oxychlorochin><Oxychloroquine><PD 1><PD-1><PD1><Patents><Physiological Homeostasis><Platelet Transforming Growth Factor><Play><Production><Proteins><RANKL><Receptor Protein><Replicative Senescence><Reporting><Role><SIS cytokines><Subcellular Process><Surface><T cell growth factor><T-Cell Activation><T-Cell Growth Factor><T-Cell Stimulating Factor><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><TNF receptor-associated factor 3><TNFSF11><TNFSF11 gene><TRAF-3><TRAF3><Testing><Th-1 Cell><Th1 Cells><Thymocyte Stimulating Factor><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Type 1 Helper Cell><activate T cells><adapter protein><age induced osteoporosis><age related osteoporosis><age reversal><age-associated bone loss><age-related inflammation><aged mice><aged mouse><ages><aging associated inflammation><aging induced osteoporosis><aging prevention><aging reversal><aging-related osteoporosis><alleviate age related><alleviate aging><ameliorating aging><anti aging><anti geronic><antiaging><attenuate><attenuates><autoimmune condition><autoimmune disorder><autoimmunity disease><bacteriophage P1 recombinase Cre><beta Integrins><biologic><biphosphonate><bisphosphonate><bone><bone cell><bone loss><bone loss with aging><bone tissue formation><bone turnover><chemoattractant cytokine><chemokine><counter age related><counter aging><counteract age related><counteract aging><cytokine><diphosphonate><elderly mice><hRANKL2><immune check point><immune checkpoint><immunecheckpoint><inflamm-ageing><inflamm-aging><inflammation associated with aging><inhibitor><interferon gamma receptor><lFN-Gamma><membrane structure><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><new approaches><novel><novel approaches><novel strategies><novel strategy><old mice><osteoblast cell differentiation><osteoblast differentiation><osteoblastic differentiation><osteoimmunology><osteoporosis caused by aging><prevent><prevent age related><prevent aging><preventing><programmed cell death 1><programmed cell death protein 1><programmed death 1><promoter><promotor><receptor><replicative aging><reverse age><reverse aging><reverse aging effects><reversible aging><sOdf><senescence><senescent><sle2><social role><suppress aging><systemic lupus erythematosus susceptibility 2><thymus derived lymphocyte><transcriptomics><β-Integrins>

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Huaizhu Wu

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Good lead · 52/100

Likely hiring

Solid budget

Active award

$388,294

FY 2026

Project Title

Inflammation and insulin resistance in aging

Grant Number:

5R01AG065197-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Aging (referring to middle age) is commonly associated with visceral adiposity and insulin resistance. Impaired white adipose tissue (AT) “browning” and reduced energy expenditure that also occur in aging may contribute to age-linked adiposity, yet how AT browning and metabolism are regulated with a...

Research Terms

<9-Octadecenoic Acid><Abdominal obesity><Ablation><Adipocytes><Adipose Cell><Adipose tissue><Age><Aging><Android fat distribution><Assay><Basal Transcription Factor><Basal transcription factor genes><Bioassay><Biological Assay><Body Tissues><Brown Adipose Tissue><Brown Fat><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central obesity><Centripetal obesity><Clinical><Data><Diet><Disease><Disorder><Dysfunction><Energy Expenditure><Energy Metabolism><Fat Cells><Fats><Fatty Tissue><Fatty acid glycerol esters><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional disorder><General Transcription Factor Gene><General Transcription Factors><Hibernating Gland><Human><Immune Cell Activation><Impairment><Inflammation><Insulin Resistance><Intermediary Metabolism><Intracellular Communication and Signaling><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Leanness><Link><Lipocytes><Mature Lipocyte><Mature fat cell><Mediating><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolic dysfunction><Metabolism><Mice><Mice Mammals><Modern Man><Murine><Mus><Null Mouse><Obesity><Oleic Acids><Organ><Pathway interactions><Phosphorylation><Physiopathology><Pilot Projects><Play><Protein Phosphorylation><RNA Seq><RNA sequencing><RNAseq><Regulation><Regulatory T-Lymphocyte><Reporting><Repression><Research Specimen><Role><STAT1><STAT1 gene><STAT91><Signal Transduction><Signal Transduction Systems><Signaling><Specimen><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cell Proliferation><T-Cells><T-Lymphocyte><T-cell inflamed><T-cell therapeutics><T-cell transfer therapy><Techniques><Testing><Thesaurismosis><Thinness><Tissues><Transcription Factor Proto-Oncogene><Transcription factor genes><Treg><Truncal obesity><Visceral><Weight Gain><Weight Increase><Wild Type Mouse><adipose><adiposity><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><age associated><age correlated><age dependent><age linked><age related><age specific><ages><aging associated><aging related><ameliorating inflammaging><anti-inflammaging><attenuate inflammaging><biological signal transduction><body weight gain><body weight increase><cis-9-Octadecenoic Acid><corpulence><dietary><diets><flow cytophotometry><immune activation><improved><inflammaging mitigation><inhibitor><insulin resistant><insulin sensitivity><insulin tolerance><metabolism disorder><mid life><mid-life><middle age><middle aged><midlife><mitigate age related inflammation><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathophysiology><pathway><pharmacologic><pilot study><prevent><prevent age related inflammation><prevent inflammaging><preventing><reducing age related inflammation><regulatory T-cells><social role><therapeutic T-cell platform><thymus derived lymphocyte><tissue culture><transcription factor><transcriptome sequencing><transcriptomic sequencing><visceral obesity><white adipose tissue><wildtype mouse><wt gain><yellow adipose tissue>

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Vikki Marie Weake

PURDUE UNIVERSITY, WEST LAFAYETTE, IN

Good lead · 52/100

Likely hiring

Solid budget

Active award

$373,008

FY 2026

Project Title

Chromatin connects metabolism to circadian gene regulation in the aging eye

Grant Number:

5R01EY033734-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2026

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Changes in metabolism in the aging eye can affect its epigenome because several metabolic intermediates also act as donor molecules for deposition of epigenetic marks such as histone and DNA methylation. During aging, there are changes in the metabolic pathways that produce the donor molecule requir...

Research Terms

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Kenneth Adam Bohnert

LOUISIANA STATE UNIV A&M COL BATON ROUGE, BATON ROUGE, LA

Good lead · 52/100

Likely hiring

Solid budget

Active award

$297,868

FY 2026

Project Title

Pexophagy regulation in live animals and its role in aging and longevity

Grant Number:

5R01AG079970-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract Aging often manifests as physiological decline at an organismal level. However, the aging process has its roots at the level of cells; changes to molecules and cellular compartments ultimately underlie physiological decline and age-related disease pathology. Clarifying cellu...

Research Terms

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KIM M. HUFFMAN

DUKE UNIVERSITY, DURHAM, NC

Good lead · 48/100

Above-average budget

Very recent

Active award

$642,802

FY 2026

Project Title

ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY

Grant Number:

2R33AG070455-06

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2021

End Date:

3/31/2031

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

In direct response to PA-23-054, Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies, we propose continued development and utilization of the CALERIE Research Network to inform aging biology. The Comprehensive Assessment of Long-Term Effects of R...

Research Terms

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WILLIAM E KRAUS

DUKE UNIVERSITY, DURHAM, NC

Good lead · 48/100

Above-average budget

Very recent

Active award

$642,802

FY 2026

Project Title

ENHANCING THE CALERIE NETWORK TO ADVANCE AGING BIOLOGY

Grant Number:

2R33AG070455-06

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2021

End Date:

3/31/2031

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

In direct response to PA-23-054, Advanced-Stage Development and Utilization of Research Infrastructure for Interdisciplinary Aging Studies, we propose continued development and utilization of the CALERIE Research Network to inform aging biology. The Comprehensive Assessment of Long-Term Effects of R...

Research Terms

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ROBERTA EILEEN BRINTON

UNIVERSITY OF ARIZONA, TUCSON, AZ

Good lead · 48/100

Above-average budget

Very recent

Active award

$537,250

FY 2026

Project Title

Aging and Estrogenic Control of the Bioenergetic System in Brain

Grant Number:

5R37AG053589-10

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2017

End Date:

3/31/2027

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Our earlier mechanistic analyses of estrogen action in brain led to the discovery that estrogen is a master regulator of the bioenergetic system in brain that promotes glucose transport, glucose metabolism, mitochondrial respiration and ATP generation. Collectively, the data provided compelling evid...

Research Terms

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Sung-Hee Lee

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 48/100

Solid budget

Very recent

Active award

Team-scale grant

$388,282

FY 2026

Project Title

Network for Advancing Methodological Research in Longitudinal Studies of Aging

Grant Number:

5U24AG077012-05

Activity Code:

U24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Longitudinal studies of the population near, through and after the retirement stage, such as the Health and Retirement Study (HRS), play an important role in aging research because they provide data from a life course perspective, allowing researchers to make population-level causal inference. Becau...

Research Terms

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Brady T West

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 48/100

Solid budget

Very recent

Active award

Team-scale grant

$388,282

FY 2026

Project Title

Network for Advancing Methodological Research in Longitudinal Studies of Aging

Grant Number:

5U24AG077012-05

Activity Code:

U24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2022

End Date:

3/31/2027

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Longitudinal studies of the population near, through and after the retirement stage, such as the Health and Retirement Study (HRS), play an important role in aging research because they provide data from a life course perspective, allowing researchers to make population-level causal inference. Becau...

Research Terms

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Scott L Letendre

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 48/100

Training-friendly

Very recent

Active award

$209,974

FY 2026

Project Title

Sustained Training in Aging and HIV Research (STAHR)

Grant Number:

5R25MH108389-09

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2016

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This application proposes to continue to develop, implement, and evaluate the highly successful Sustained Training on Aging and HIV Research (STAHR) research training program, which has the goal of expanding the pool of NIMH-funded new investigators performing research of HIV, aging, and mental heal...

Research Terms

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DAVID J MOORE

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 48/100

Training-friendly

Very recent

Active award

$209,974

FY 2026

Project Title

Sustained Training in Aging and HIV Research (STAHR)

Grant Number:

5R25MH108389-09

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2016

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This application proposes to continue to develop, implement, and evaluate the highly successful Sustained Training on Aging and HIV Research (STAHR) research training program, which has the goal of expanding the pool of NIMH-funded new investigators performing research of HIV, aging, and mental heal...

Research Terms

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Erin elizabeth Sundermann

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Good lead · 48/100

Training-friendly

Very recent

Active award

$209,974

FY 2026

Project Title

Sustained Training in Aging and HIV Research (STAHR)

Grant Number:

5R25MH108389-09

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2016

End Date:

3/31/2028

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This application proposes to continue to develop, implement, and evaluate the highly successful Sustained Training on Aging and HIV Research (STAHR) research training program, which has the goal of expanding the pool of NIMH-funded new investigators performing research of HIV, aging, and mental heal...

Research Terms

View Full Project Details on NIH Reporter

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Ryo Higuchi-Sanabria

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Good lead · 48/100

Likely hiring

Recent

Active award

$160,741

FY 2026

Project Title

When actin's not actin like actin: Nuclear actin impacts transcription and aging

Grant Number:

3R01AG079806-03S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

1/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary The functional significance of actin in cellular health and fitness is unquestionable, as the actin cytoskeleton is required for a diverse array of cellular processes as simple as movement and motility. The loss of function of actin is seen in clinical manifestations in many disease...

Research Terms

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William H Dow

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Good lead · 48/100

Likely hiring

Recent

Active award

$160,274

FY 2026

Project Title

Costa Rican Longevity and Healthy Aging Study (CRELES): Wave 4

Grant Number:

5R01AG091512-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

12/31/2029

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary / Abstract Costa Rican Longevity and Healthy Aging Study (CRELES): Wave 4 Costa Rica has been long recognized as an important country to study based on its achievement of “good health at low cost.” Despite being a middle-income country, its life expectancy is among the highest in Lat...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><ADRD><Achievement><Achievement Attainment><Active Follow-up><Adult><Adult Human><Age><Aging><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Amentia><Biological Markers><Birth><Blood><Blood Reticuloendothelial System><Cessation of life><Cognitive><Cognitive aging><Communities><Costa Rica><Costa Rican><Country><Data><Data Set><Death><Dementia><Economic Income><Economical Income><Family Research><Geography><Health><Health Expenditures><Health and Retirement Study><Income><International><Interview><Investments><LMIC><Latin America><Length of Life><Life Expectancy><Long-term Follow-up><Longevity><Married Persons><Measurement><Mexico><National Academy of Sciences><Parturition><Pattern><Performance><Population><Protocol><Protocols documentation><Puerto Rico><Questionnaires><Research><Respondent><Rest><Retirement><Running><Sample Size><Sampling Studies><Socio-economic status><Socioeconomic Status><Spouses><Survey Instrument><Surveys><Survivors><Time><United States><United States National Academy of Sciences><Update><Venous><Vital Statistics><Work><active followup><adulthood><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging population><bio-markers><biologic marker><biomarker><burden of chronic disease><burden of chronic illness><cognitive assessment><cognitive performance><cognitive testing><cohort><cost><design><designing><family based research><family centered research><family focused research><family investigation><follow up><follow-up><followed up><followup><health care expenditure><health data><healthy aging><healthy human aging><incomes><indexing><informant><innovate><innovation><innovative><investigate family><long-term followup><low and middle-income countries><medical expenditure><mortality><old age><older adult><older adulthood><performance tests><physical conditioning><physical health><population aging><retirements><safety net><social><socio-economic><socio-economic position><socio-economically><socioeconomic position><socioeconomically><socioeconomics><study family><success><survey family>

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BRIAN D CARPENTER

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Good lead · 48/100

Training-friendly

Very recent

Active award

$130,973

FY 2026

Project Title

Enhancing Undergraduate Preparation for Research in Aging and Neurologic Diseases

Grant Number:

5R25NS100133-08

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2018

End Date:

2/28/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.
• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

In the decades ahead, demographic trends suggest that the sheer number of older adults will increase, and they will make up a larger proportion of the overall population. Many of these individuals will experience some type of neurological disease at some point in their life. Consequently, we need an...

Research Terms

<5 year old><5 years of age><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Address><Aged 65 and Over><Aging><Amentia><Apoplexy><Attitude><Behavioral><Behavioral Research><Biomedical Research><Brain Vascular Accident><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Clinical><Clinical Research><Clinical Study><Communities><Country><Dementia><Development><Educational process of instructing><Elements><Faculty><Family><Fostering><Future><Generalized Growth><Goals><Growth><Health Care Systems><Home><Individual><Institution><Intervention><Investigation><Investigators><Knowledge><Laboratories><Laboratory Research><Learning><Life><Mentors><Modification><Nervous System Diseases><Nervous System Disorder><Neurologic><Neurologic Disorders><Neurological><Neurological Disorders><Paralysis Agitans><Parkinson><Parkinson Disease><Patients><Persons><Population><Preparation><Prevention><Primary Parkinsonism><Process><Public Health><Research><Research Personnel><Research Resources><Research Training><Researchers><Resources><Scholarship><Science><Scientist><Societies><Stroke><Structure><Students><Teaching><Tissue Growth><Training><United Nations><United States><Universities><Washington><Work><above age 65><after age 65><age 5><age 5 years><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aged ≥65><aging population><aging process><brain attack><built environment><care partner><caregiving partner><cerebral vascular accident><cerebrovascular accident><cohort><developmental><experience><field trip><five year old><five years of age><hands on research><homes><human old age (65+)><interdisciplinary approach><interest><lab experience><lab training><laboratory experience><laboratory training><later in life><later life><lectures><member><multidisciplinary><multidisciplinary approach><neurological disease><older adult><older adulthood><ontogeny><over 65 years><population aging><posters><preparations><programs><recruit><skills><social><stroked><strokes><summer program><summer research><summer session><summer undergraduate training><trend><undergrad><undergraduate><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student><undergraduate summer program><undergraduate summer research><≥65 years>

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Daniella E. Chusyd

TRUSTEES OF INDIANA UNIVERSITY, BLOOMINGTON, IN

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$130,638

FY 2026

Project Title

Early life trauma and aging using a long-lived animal model

Grant Number:

5K01AG072615-05

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/15/2022

End Date:

12/31/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT Training: My research over the past eight years has focused primarily on elephant endocrinology, health, and aging. The work has shown that there are many similarities between elephants and humans (e.g., morbidities, life history, socialness, emotional complexity), and that ...

Research Terms

<0-11 years old><21+ years old><Abscission><Address><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Age><Aging><Animal Model><Animal Models and Related Studies><Antioncogene Protein p53><Apoplexy><Applications Grants><Area><Autoimmune Diseases><Award><Awareness><Behavior><Biological><Brain Vascular Accident><Cancers><Cardiac Diseases><Cardiac Disorders><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Cellular Tumor Antigen P53><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Child><Child Youth><Childhood><Children (0-21)><Chronology><Cognition><Conflict><Conflict (Psychology)><Development><Diabetes Mellitus><Diathesis><Disease><Disease Progression><Disease susceptibility><Disorder><Doctor of Philosophy><Dose><Early Trauma><Early-life trauma><Education><Educational aspects><Effectiveness><Elephants><Emotional><Endocrine system><Endocrine/Metabolic Organ System><Endocrinology><Environment><Ethics><Ethnic Origin><Ethnicity><Excision><Exercise><Exposure to><Extirpation><Family><Family member><Food><Fostering><Genetic><Goals><Grant Proposals><Hand><Health><Heart Diseases><Hormonal System><Human><Hydrogen Oxide><Immune system><Individual><Intelligence><Interruption><Intervention><Investigators><Ixodida><K-Awards><K-Series Research Career Programs><Ketosis-Resistant Diabetes Mellitus><Lead><Learning><Life><Life Expectancy><Malignant Neoplasms><Malignant Tumor><Maturity-Onset Diabetes Mellitus><Memory><Mentorship><Metabolic/Endocrine Body System><Metabolism and Endocrinology><Methods><Modeling><Modern Man><Morbidity><Mothers><NIDDM><Natural experiment><Nervous System><Neurologic Body System><Neurologic Organ System><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Northern Rhodesia><Obesity><Oncoprotein p53><Orphan><Orphanages><Outcome><P53><PTSD><Parasites><Parents><Pb element><Persons><Ph.D.><PhD><Phosphoprotein P53><Phosphoprotein pp53><Physiologic><Physiological><Population><Population Research><Population-based research><Population-level research><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Predisposition><Prevalence><Property><Protein TP53><Public Health><Randomized><Removal><Research><Research Career Program><Research Personnel><Researchers><Risk><Sampling><Science><Scientist><Slow-Onset Diabetes Mellitus><Smoking><Socio-economic status><Socioeconomic Status><Source><Stable Diabetes Mellitus><Stroke><Surgical Removal><Susceptibility><System><T2 DM><T2D><T2DM><TP53><TP53 gene><TRP53><Ticks><Time><Training><Training Activity><Trauma><Tumor Protein p53><Tumor Protein p53 Gene><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Variant><Variation><Water><Work><Zambia><accelerated aging><accelerated biological age><accelerated biological aging><adiposity><adult onset diabetes><adulthood><adverse childhood events><adverse childhood experiences><affiliative behavior><age acceleration><ages><aging associated><aging related><allostases><allostasis><allostatic load><antisocial behavior><autoimmune condition><autoimmune disorder><autoimmunity disease><behavioral health><biologic><biological adaptation to stress><biological age><biological basis of behavior><biopsychology><brain attack><career development><cerebral vascular accident><cerebrovascular accident><cognitive function><cognitive task><corpulence><design><designing><developmental><diabetes><early life exposure><endocrine gland/system><ethical><experience><experiment><experimental research><experimental study><experiments><feasibility testing><hands><healthy aging><healthy human aging><heart disorder><heavy metal Pb><heavy metal lead><improved><information gathering><innovate><innovation><innovative><insight><inter-individual variability><inter-individual variation><investigate population><ketosis resistant diabetes><kids><later in life><later life><liability to disease><life history><life span><lifespan><malignancy><maturity onset diabetes><model of animal><mortality><neoplasm/cancer><p53 Antigen><p53 Genes><p53 Tumor Suppressor><pace of aging><pace of biological aging><parent><pediatric><pilot test><poor health outcome><population investigation><population level investigation><population specific research><post-trauma stress disorder><posttrauma stress disorder><protein p53><psychobiology><psychologic><psychological><randomisation><randomization><randomly assigned><rate of aging><rate of biological aging><reactioncrisis><reduced health outcome><resection><response><sex><skills><social><social health determinants><social learning><social norm><socio-economic position><socioeconomic position><speed of aging><speed of the aging><standard care><standard treatment><stress response><stressreaction><stressor><stroked><strokes><studies of populations><study of the population><study population><survey population><training module><trait><traumatic neurosis><type 2 DM><type II DM><type two diabetes><worse health outcome><youngster>

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Ruth H. Asch

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Good lead · 48/100

Training-friendly

Recent

Active award

Career award

$127,386

FY 2026

Project Title

Stress and aging: longitudinal evaluation of synaptic changes using in vivo SV2A PET

Grant Number:

7K01AG090892-02

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY This Mentored Research Scientist Career Development Award proposal is designed to provide advanced training, expert mentoring, and hands-on research experience that will facilitate my successful transition to research independence. My primary career goal is to establish myself as a ...

Research Terms

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Laura M Calvi

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 48/100

Likely hiring

Recent

Active award

$11,060

FY 2026

Project Title

Efferocytosis by Bone Marrow Stromal Cells and Bone Aging

Grant Number:

3R01AG076786-05S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Efferocytosis by bone marrow stromal cells and bone aging Pre-clinical studies show that senescent bone marrow-derived mesenchymal stromal (a.k.a. stem) cells (MSCs) and osteolineage cells contribute to age-dependent bone loss and bone marrow failure. Therefore, the identification of novel mechanism...

Research Terms

<21+ years old><AMD-3100><AMD3100><Acceleration><Active Oxygen><Address><Adult><Adult Human><Aging><Apoptosis><Apoptosis Pathway><Apoptotic><Autoregulation><BAI1><BAI1 gene><BM Stem Cell><BM derived progenitor><BM progenitor><BM- derived Stem Cells><Beta Proprotein Interleukin 1><Biology><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Marrow Stem Cell><Bone Marrow progenitor><Bone marrow failure><Brain-specific Angiogenesis Inhibitor 1><Breast Cancer><CDw128b><CMKAR2><COPD><CXC-R4><CXCL1><CXCL1 gene><CXCL12><CXCL12 gene><CXCL12 protein><CXCR-4><CXCR2><CXCR4><CXCR4 gene><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cell Senescence Induction><Cell Signaling><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Chemokine (C-X-C Motif) Ligand 12><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clinical Trials><D2S201E><DNA Recombination><Data><Degenerative Disorder><Development><Disease><Disorder><Dose><Dysfunction><FB22><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional disorder><GRO1><GROA><Gene Transcription><Genetic Models><Genetic Recombination><Genetic Transcription><Goals><HM89><HSY3RR><Health><Homeostasis><Human><IGF-1><IGF-I><IGF-I-SmC><IL-1><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL1><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><IL8R2><IL8RB><IL8RB gene><Immune><Immunes><Impairment><In Vitro><Inflammation><Inflammatory><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Interleukin 1beta><Interleukin I><Interleukin-1><Interleukin-1 beta><Interleukin-1β><Intracellular Communication and Signaling><Knowledge><LAP3><LCR1><LESTR><Label><Length of Life><Longevity><Lymphocyte-Stimulating Hormone><MGSA><Macrophage><Macrophage Cell Factor><Maintenance><Malignant Breast Neoplasm><Malignant Pancreatic Neoplasm><Malignant neoplasm of pancreas><Marrow Neutrophil><Measures><Mediating><Mesenchymal><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Metabolic><Metals><Mice><Mice Mammals><Mission><Mitochondria><Modeling><Modern Man><Molecular><Murine><Mus><Mφ><NIH><NPY3R><NPYR><NPYRL><NPYY3R><National Institutes of Health><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxidative Stress><Oxidative Stress Induction><Oxygen Radicals><PBSF><Pancreas Cancer><Pancreatic Cancer><Pathogenicity><Pathologic><Phagocytes><Phagocytic Cell><Phagocytosis><Phenotype><Physiological Homeostasis><Physiology><Physiopathology><Plerixafor><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Pre-B Cell Growth Stimulating Factor><Preinterleukin 1 Beta><Pro-Oxidants><Process><Programmed Cell Death><Public Health><RNA Expression><Reactive Oxygen Species><Receptor Protein><Recombination><Replicative Senescence><Reporting><Role><SCYB1><SCYB12><SDF-1><SDF-1A><SDF-1B><SDF-1alpha><SDF1><SDF1A><SDF1B><Sdf1 protein><Signal Transduction><Signal Transduction Systems><Signaling><Skeleton><Somatomedin C><Stromal Cell-Derived Factor 1><Subcellular Process><T Helper Factor><TLSF-A><TLSF-B><TPAR1><Tamoxifen><Testing><Transcription><Transgenic Organisms><United States National Institutes of Health><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged bone><aged mice><aged mouse><amebocyte><antagonism><antagonist><anti-oxidant enzyme><antioxidant enzyme><biological signal transduction><biomechanical analyses><biomechanical analysis><biomechanical assessment><biomechanical characterization><biomechanical evaluation><biomechanical measurement><biomechanical profiling><biomechanical test><bone><bone aging><bone health><bone loss><bone marrow derived progenitor><bone marrow derived stem cells><bone marrow stromal cell><bone marrow stromal stem cell><bone repair><bone turnover><catalase><cellular aging induction><cellular senescence induction><chronic obstructive pulmonary disorder><compound repositioning><compound repurposing><degenerative condition><degenerative disease><developmental><disability><drug repositioning><drug repurposing><elderly mice><flow cytophotometry><gain of function><hIRH><improved><in vivo><inhibitor><innovate><innovation><innovative><loss of function><lymphocyte activating factor><malignant breast tumor><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><mitochondrial><mitochondrial dysfunction><mouse model><murine model><neutrophil><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic uses for existing drugs><new therapeutics><new therapy><new use of drug><new uses for an approved drug><new uses for existing drugs><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><old mice><osteoblast cell differentiation><osteoblast differentiation><osteoblastic differentiation><osteogenic><osteoimmunology><overexpress><overexpression><pancreatic malignancy><particle><pathogen><pathophysiology><pharmacologic><pharmacological repurposing><pre-clinical study><preclinical study><prevent><preventing><pro-aging><progeronic><programs><promote aging><receptor><replicative aging><repositioning approved drugs><repositioning existing drugs><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><response><scRNA sequencing><scRNA-seq><senescence><senescence induction><senescent><serine receptor><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skeletal><skeletons><social role><stem><stromal cell-derived factor-1alpha><therapeutic repositioning><therapeutic repurposing><transgenic>

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Roman Eliseev

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 48/100

Likely hiring

Recent

Active award

$11,060

FY 2026

Project Title

Efferocytosis by Bone Marrow Stromal Cells and Bone Aging

Grant Number:

3R01AG076786-05S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2022

End Date:

2/28/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

Efferocytosis by bone marrow stromal cells and bone aging Pre-clinical studies show that senescent bone marrow-derived mesenchymal stromal (a.k.a. stem) cells (MSCs) and osteolineage cells contribute to age-dependent bone loss and bone marrow failure. Therefore, the identification of novel mechanism...

Research Terms

<21+ years old><AMD-3100><AMD3100><Acceleration><Active Oxygen><Address><Adult><Adult Human><Aging><Apoptosis><Apoptosis Pathway><Apoptotic><Autoregulation><BAI1><BAI1 gene><BM Stem Cell><BM derived progenitor><BM progenitor><BM- derived Stem Cells><Beta Proprotein Interleukin 1><Biology><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Marrow Stem Cell><Bone Marrow progenitor><Bone marrow failure><Brain-specific Angiogenesis Inhibitor 1><Breast Cancer><CDw128b><CMKAR2><COPD><CXC-R4><CXCL1><CXCL1 gene><CXCL12><CXCL12 gene><CXCL12 protein><CXCR-4><CXCR2><CXCR4><CXCR4 gene><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cell Senescence Induction><Cell Signaling><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Chemokine (C-X-C Motif) Ligand 12><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clinical Trials><D2S201E><DNA Recombination><Data><Degenerative Disorder><Development><Disease><Disorder><Dose><Dysfunction><FB22><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional disorder><GRO1><GROA><Gene Transcription><Genetic Models><Genetic Recombination><Genetic Transcription><Goals><HM89><HSY3RR><Health><Homeostasis><Human><IGF-1><IGF-I><IGF-I-SmC><IL-1><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL1><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><IL8R2><IL8RB><IL8RB gene><Immune><Immunes><Impairment><In Vitro><Inflammation><Inflammatory><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Interleukin 1beta><Interleukin I><Interleukin-1><Interleukin-1 beta><Interleukin-1β><Intracellular Communication and Signaling><Knowledge><LAP3><LCR1><LESTR><Label><Length of Life><Longevity><Lymphocyte-Stimulating Hormone><MGSA><Macrophage><Macrophage Cell Factor><Maintenance><Malignant Breast Neoplasm><Malignant Pancreatic Neoplasm><Malignant neoplasm of pancreas><Marrow Neutrophil><Measures><Mediating><Mesenchymal><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Metabolic><Metals><Mice><Mice Mammals><Mission><Mitochondria><Modeling><Modern Man><Molecular><Murine><Mus><Mφ><NIH><NPY3R><NPYR><NPYRL><NPYY3R><National Institutes of Health><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxidative Stress><Oxidative Stress Induction><Oxygen Radicals><PBSF><Pancreas Cancer><Pancreatic Cancer><Pathogenicity><Pathologic><Phagocytes><Phagocytic Cell><Phagocytosis><Phenotype><Physiological Homeostasis><Physiology><Physiopathology><Plerixafor><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Pre-B Cell Growth Stimulating Factor><Preinterleukin 1 Beta><Pro-Oxidants><Process><Programmed Cell Death><Public Health><RNA Expression><Reactive Oxygen Species><Receptor Protein><Recombination><Replicative Senescence><Reporting><Role><SCYB1><SCYB12><SDF-1><SDF-1A><SDF-1B><SDF-1alpha><SDF1><SDF1A><SDF1B><Sdf1 protein><Signal Transduction><Signal Transduction Systems><Signaling><Skeleton><Somatomedin C><Stromal Cell-Derived Factor 1><Subcellular Process><T Helper Factor><TLSF-A><TLSF-B><TPAR1><Tamoxifen><Testing><Transcription><Transgenic Organisms><United States National Institutes of Health><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><aged bone><aged mice><aged mouse><amebocyte><antagonism><antagonist><anti-oxidant enzyme><antioxidant enzyme><biological signal transduction><biomechanical analyses><biomechanical analysis><biomechanical assessment><biomechanical characterization><biomechanical evaluation><biomechanical measurement><biomechanical profiling><biomechanical test><bone><bone aging><bone health><bone loss><bone marrow derived progenitor><bone marrow derived stem cells><bone marrow stromal cell><bone marrow stromal stem cell><bone repair><bone turnover><catalase><cellular aging induction><cellular senescence induction><chronic obstructive pulmonary disorder><compound repositioning><compound repurposing><degenerative condition><degenerative disease><developmental><disability><drug repositioning><drug repurposing><elderly mice><flow cytophotometry><gain of function><hIRH><improved><in vivo><inhibitor><innovate><innovation><innovative><loss of function><lymphocyte activating factor><malignant breast tumor><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><mitochondrial><mitochondrial dysfunction><mouse model><murine model><neutrophil><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic uses for existing drugs><new therapeutics><new therapy><new use of drug><new uses for an approved drug><new uses for existing drugs><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><old mice><osteoblast cell differentiation><osteoblast differentiation><osteoblastic differentiation><osteogenic><osteoimmunology><overexpress><overexpression><pancreatic malignancy><particle><pathogen><pathophysiology><pharmacologic><pharmacological repurposing><pre-clinical study><preclinical study><prevent><preventing><pro-aging><progeronic><programs><promote aging><receptor><replicative aging><repositioning approved drugs><repositioning existing drugs><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><response><scRNA sequencing><scRNA-seq><senescence><senescence induction><senescent><serine receptor><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skeletal><skeletons><social role><stem><stromal cell-derived factor-1alpha><therapeutic repositioning><therapeutic repurposing><transgenic>

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Alexendar Reinaldo Perez

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$190,311

FY 2026

Project Title

Role of Transposable Elements in Septic Immune Aging

Grant Number:

5K08GM157557-02

Activity Code:

K08

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Sepsis is an overwhelming, maladaptive, and lethal dysregulation of the immune response to infection. Annually, approximately 50 million people suffer from sepsis with 11 million resulting deaths worldwide. Age is one of the strongest risk factors for mortality from sepsis. Aging cor...

Research Terms

<21+ years old><Acceleration><Adult><Adult Human><Affect><Age><Aging><Automobile Driving><B-Cells><B-Lymphocytes><B-cell><Blood Sample><Blood Serum><Blood specimen><CRISPR><CRISPR/Cas system><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cessation of life><Clustered Regularly Interspaced Short Palindromic Repeats><Computer Models><Computerized Models><Critical Illness><Critically Ill><DNA Transposable Elements><DNA mutation><Data><Death><Experimental Genetics><Family><Flies><Gene Expression><Gene Transcription><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genomics><Human><Human Genome><IFN><IFN activation><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immune system><Immunes><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Incidence><Individual><Infection><Inflammaging><Inflammation><Inflammatory><Intensive Care Units><Interferon Activation><Interferons><Intracellular Communication and Signaling><Investigation><Lead><Learning><Machine Learning><Maintenance><Malignant Neoplasms><Malignant Tumor><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Morbidity><Murine><Mus><Mutation><Outcome><Participant><Pathogenesis><Pathologic><Pathway interactions><Patient Admission><Patients><Pb element><Persons><Phenotype><Physiologic><Physiological><Play><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Repetitive Element><Repetitive Regions><Repetitive Sequence><Repression><Research><Rest><Risk Factors><Role><Sampling><Sepsis><Serum><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Sterility><Stimulus><T-Cells><T-Lymphocyte><Transcription><Transposable Elements><Viral><Viral Diseases><Virus Diseases><Whole Blood><Work><accelerated aging><accelerated biological age><accelerated biological aging><adulthood><age acceleration><age associated><age correlated><age dependent><age linked><age related><age specific><age-related inflammation><ages><aging associated inflammation><aging process><biological signal transduction><cell age><cellular age><cohort><computational modeling><computational models><computer based models><computer based prediction><computerized modeling><death due to sepsis><death related to sepsis><derepression><differential expression><differentially expressed><driving><exome sequencing><exome-seq><fly><genetic element><genome mutation><healthy volunteer><heavy metal Pb><heavy metal lead><host response><human whole genome><immune system response><immunoresponse><individuals with sepsis><inflamm-ageing><inflamm-aging><inflammation associated with aging><inflammatory environment><inflammatory milieu><machine based learning><malignancy><mimicry><model organism><mortality><mortality associated with sepsis><mortality in sepsis><neoplasm/cancer><network models><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><outcome prediction><pathway><patients with sepsis><people with sepsis><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><predictive modeling><programs><response><reverse genetics><secondary infection><sepsis associated death><sepsis associated mortality><sepsis caused deaths><sepsis death><sepsis groups><sepsis induced death><sepsis induced mortality><sepsis lethality><sepsis mortality><sepsis patients><sepsis population><sepsis related deaths><sepsis related mortality><sepsis subjects><septic><septic death><septic group><septic individuals><septic mortality><septic patients><septic people><septic population><septic subject><social role><sterile><subjects with sepsis><thymus derived lymphocyte><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><viral infection><virus infection><virus-induced disease><volunteer>

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Ines Sturmlechner

MAYO CLINIC ROCHESTER, ROCHESTER, MN

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$133,353

FY 2026

Project Title

T cell surveillance of senescent cells under homeostasis and aging

Grant Number:

5K99AG090620-02

Activity Code:

K99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT RESEARCH: Aging is the single greatest risk factor for a multitude of morbidities. While multifactorial, a central mechanism of aging is cellular senescence, a complex, context-dependent cell fate with important roles in both, physiological and pathological processes. The ac...

Research Terms

<70 kDa zeta-associated protein><Abscission><Acceleration><Acute><Address><Adhesions><Age><Aging><Antibodies><Assay><Autoregulation><B7-H1><Bioassay><Biological Assay><Body Tissues><CD152><CD152 Antigen><CD152 Gene><CD274><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CTLA 4><CTLA-4 Gene><CTLA4><CTLA4 gene><CTLA4-TM><Cancers><Candidate Disease Gene><Candidate Gene><Cell Adhesion><Cell Aging><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Senescence><Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Adhesion><Cellular Aging><Cellular Senescence><Clinic><Co-culture><Cocultivation><Coculture><Coculture Techniques><Communication><Complex><Cytotoxic T-Lymphocyte Protein 4><Cytotoxic T-Lymphocyte-Associated Antigen 4><Cytotoxic T-Lymphocyte-Associated Protein 4><Cytotoxic T-Lymphocyte-Associated Serine Esterase-4><Data><Dedications><Degenerative Neurologic Disorders><Development><Disease><Disorder><Doctor of Philosophy><Dysfunction><Epithelium><Excision><Extirpation><Fibroblasts><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Foundations><Functional disorder><Funding><Generations><Goals><Homeostasis><Hospitals><Human><Immune><Immune Evasion><Immune Surveillance><Immune mediated therapy><Immune response><Immunes><Immunofluorescence><Immunofluorescence Immunologic><Immunologic Surveillance><Immunologically Directed Therapy><Immunosurveillance><Immunotherapy><Impairment><In Vitro><Infection><Injury><Institution><Intracellular Communication and Signaling><Investigators><Kidney><Kidney Diseases><Kidney Urinary System><Knowledge><Life><Ligands><Link><Lytotoxicity><Malignant Neoplasms><Malignant Tumor><Mediating><Mentors><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Morbidity><Murine><Mus><Nephropathy><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Organism-Level Process><Organismal Process><Outcome><PD 1><PD-1><PD-L1><PD1><PDL-1><Pathologic><Pathologic Processes><Pathological Processes><Pathology><Pathway interactions><Peripheral><Ph.D.><PhD><Phase><Phenotype><Phosphorylation><Physiologic><Physiologic Processes><Physiological><Physiological Homeostasis><Physiological Processes><Physiopathology><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Process><Production><Programmed Cell Death 1 Ligand 1><Programmed Death Ligand 1><Proliferating><Property><Protein Phosphorylation><Protein Tyrosine Kinase Zap70><Receptor Cell><Removal><Renal Cell><Renal Disease><Replicative Senescence><Research><Research Associate><Research Personnel><Research Specimen><Researchers><Risk Factors><Role><Route><SRK><Sampling><Secure><Series><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Specimen><Surgical Removal><Syk-related tyrosine kinase><T cell response><T-Cell Activation><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T8 Cells><T8 Lymphocytes><Techniques><Testing><Time><Tissues><Training><Translational Research Enterprise><Work><ZAP-70><ZAP-70 Gene><ZAP-70 Kinase><ZAP-70 protein><ZAP70><Zeta-Chain Associated Protein Kinase><activate T cells><adult youth><age associated><age associated alterations><age associated changes><age associated disease><age associated disorder><age associated impairment><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent disease><age dependent disorder><age dependent impairment><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related human disease><age related pathways><age specific><age specific alterations><age specific changes><age-related disease><age-related disorder><age-related impairment><ages><aging associated alterations><aging associated changes><aging associated mechanism><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging mechanism><aging pathway><aging related alterations><aging related changes><aging related mechanism><aging related pathways><aging specific alterations><aging specific changes><alterations with age><autoimmune reactivity><autoreactivity><biological mechanism of age><biological pathways of age><biological signal transduction><career><changes with age><check point blockade><checkpoint blockade><cytokine><cytotoxic T-lymphocyte antigen 4><cytotoxicity><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><experiment><experimental research><experimental study><experiments><exposed human population><flow cytophotometry><healthspan><healthy aging><healthy human aging><healthy life span><host response><human exposure><immune check point><immune check point blockade><immune checkpoint><immune checkpoint blockade><immune evasive><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immunecheckpoint><immuno therapy><immunogenic><immunoresponse><injuries><kidney cell><kidney disorder><malignancy><mechanism regulating aging><mechanisms involved in aging><neoplasm/cancer><neurodegenerative illness><older adult><older adulthood><pathophysiology><pathway><pathway involved in aging><permissiveness><post-doc><post-doctoral><post-doctoral trainee><programmed cell death 1><programmed cell death ligand 1><programmed cell death protein 1><programmed cell death protein ligand 1><programmed death 1><protein death-ligand 1><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><release factor><renal><renal disorder><replicative aging><research associates><resection><scRNA sequencing><scRNA-seq><senescence><senescent><senescent cell><shRNA><short hairpin RNA><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell next generation sequencing><single cell sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><skills><sle2><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><systemic lupus erythematosus susceptibility 2><thymus derived lymphocyte><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><translation research enterprise><translational research program><translational study><young adult><young adult age><young adulthood>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kelly Brooke Jarvis

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Exploratory lead · 42/100

Training-friendly

Active award

Career award

$124,065

FY 2026

Project Title

Heart-brain MRI for the evaluation of hemodynamic coupling in aging and Alzheimer's disease

Grant Number:

5K01AG080070-04

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2027

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Cardiovascular risk factors have been implicated in Alzheimer's disease and related dementias, however, mechanisms underlying heart-brain hemodynamic coupling are not well understood. Aortic stiffening has been associated with increased dementia risk. In addition to brain ch...

Research Terms

<(4D) flow MRI><21+ years old><3-D><3-Dimensional><3D><4-D MR imaging><4-D MRI><4-D flow MR imaging><4-D flow MRI><4-D flow imaging><4-D flow magnetic resonance imaging><4-D magnetic resonance imaging><4D MR imaging><4D MRI><4D flow MR imaging><4D flow MRI><4D flow imaging><4D flow magnetic resonance imaging><4D magnetic resonance imaging><AD and related dementia><AD dementia><AD patients><AD related dementia><ADRD><Abeta clearance><Acceleration><Adult><Adult Human><Affect><Age><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease patient><Alzheimer's disease related dementia><Alzheimer's patient><Alzheimers Dementia><Amentia><Amyloid β clearance><Aorta><Aβ clearance><Blood><Blood Flow Velocity><Blood Pressure><Blood Reticuloendothelial System><Blood Vessels><Blood flow><Brain><Brain Nervous System><Brain Vascular><Brain Vascular Disorders><Brain hemodynamics><Brain imaging><Buffers><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Care Givers><Caregivers><Cerebrovascular Disease><Cerebrovascular Disorders><Cerebrum><Chest><Clinical><Cognitive aging><Complex><Coupling><Data><Dedications><Dementia><Development><Encephalon><Evaluation><Foundations><Future><General Radiology><Goals><Head and Neck><Head and neck structure><Heart><Heart Vascular><Hypertension><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><Individual><Intracranial Vascular Diseases><Intracranial Vascular Disorders><Lead><Link><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methodology><Methods><NMR Imaging><NMR Tomography><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Nuclear Magnetic Resonance Imaging><Pathology><Pattern><Pb element><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D. student><PhD student><PhD. student><Physiologic><Physiologic pulse><Physiological><Pilot Projects><Postdoc><Postdoctoral Fellow><Primary Senile Degenerative Dementia><Production><Protocol><Protocols documentation><Pulsatile Flow><Pulsatile Perfusion><Pulsating Flow><Pulse><QOL improvement><Radiology><Radiology Specialty><Research><Research Associate><Scanning><Structure><Techniques><Thorace><Thoracic><Thorax><Training><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><White Matter Hyperintensity><Zeugmatography><a-beta peptide clearance><abeta peptide clearance><adulthood><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age related alterations><age related changes><age specific alterations><age specific changes><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><amyloid beta clearance><amyloid beta peptide clearance><brain MR imaging><brain MRI><brain abnormalities><brain atrophy><brain blood dynamics><brain magnetic resonance imaging><brain vascular disease><brain vascular dysfunction><brain visualization><cardiovascular imaging><cardiovascular risk><cardiovascular risk factor><cerebral><cerebral MR imaging><cerebral MRI><cerebral atrophy><cerebral hemodynamics><cerebral magnetic resonance imaging><cerebral vascular><cerebral vascular disease><cerebral vascular dysfunction><cerebro-vascular><cerebrovascular><cerebrovascular dysfunction><changes with age><circulatory system><cortical atrophy><dementia risk><design><designing><developmental><diagnostic tool><doctoral student><four dimensional MR imaging><four dimensional MRI><four dimensional flow><four dimensional magnetic resonance imaging><heavy metal Pb><heavy metal lead><hemodynamics><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improvements in QOL><improvements in quality of life><innovate><innovation><innovative><insight><intracranial vascular dysfunction><lack of physical activity><later in life><later life><malleable risk><mid life><mid-life><middle age><middle aged><midlife><modifiable risk><natural aging><neural imaging><neuro-imaging><neuroimaging><neurological imaging><neuronal><new approaches><normal aging><normative aging><novel><novel approaches><novel strategies><novel strategy><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><physical inactivity><pilot study><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><primary degenerative dementia><programs><quality of life improvement><research associates><risk factor for dementia><risk for dementia><senile dementia of the Alzheimer type><three dimensional><tool><vascular>

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Jodi A. Flaws

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Exploratory lead · 42/100

Likely hiring

Active award

$28,562

FY 2026

Project Title

Phthalate Exposure and Female Reproductive Aging

Grant Number:

3R01ES034112-04S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

10/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

The female reproductive system ages before any other physiological system, making it the most sensitive indicator of aging. Most women experience reproductive senescence around age 51, but many women experience early reproductive aging (early menopause). This is a serious public health problem becau...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><21+ years old><3-10C><AH Receptors><AMCF-I><Acceleration><Acute><Adhesives><Adult><Adult Human><Age><Aging><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Aryl Hydrocarbon Receptor><Assay><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cells><B-Lymphocytes><B-cell><BCDF><BSF-2><BSF2><Binding><Bioassay><Biological Assay><Blood Serum><Body Tissues><CCL5><CD11b><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CR3A><CSIF><CSIF-10><CXCL8><Cannot achieve a pregnancy><Cell Aging><Cell Body><Cell Count><Cell Number><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Cessation of life><Characteristics><Chemokine (C-C Motif) Ligand 5><Childbirth><Chronic><Curcumin><Cytokine Synthesis Inhibitory Factor><Cytotoxic cell><D17S136E><Data><Death><Defoaming Agents><Delayed Childbearing><Development><Diferuloylmethane><Difficulty conceiving><Dioxin Receptors><Disadvantaged><Disease><Disorder><Dose><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine Gland Secretion><Endocrine disrupting agent><Environment><Exposure to><Fecundability><Fecundity><Female><Female Genital System><Female Health><Fertility><Fibrosis><Follicle Stimulating Hormone><Follitropin><Foundations><GCP1><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Greater sac of peritoneum><Growth><HPGF><Health><Hepatocyte-Stimulating Factor><Hormones><Hybridoma Growth Factor><Hypophysis><Hypophysis Cerebri><Hypothalamic structure><Hypothalamus><IFN><IFN-beta 2><IFNB2><IL-10><IL-6><IL-8><IL10><IL10A><IL6 Protein><IL8><IL8 gene><ITGAM><ITGAM gene><Immune><Immunes><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Infertility><Inflammasome><Inflammation><Inflammatory><Interferons><Interleukin 10 Precursor><Interleukin-10><Interleukin-6><K lymphocyte><K60><KISS1><KISS1 Metastasis Suppressor><KISS1 gene><KiSS-1><Lubricants><MAC1A><MEHP><MGC17164><MGC39258><MGI-2><MO1A><Macrophage><Medical Device><Menopausal Symptom><Mental Depression><Metastin><Mice><Mice Mammals><Molecular Interaction><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><NK Cells><Natural Killer Cells><Nuclear Translocator><Osteoporosis><Ovarian Follicle><Ovary><Pathway interactions><Peritoneal Cavity><Peritoneal Macrophages><Pesticides><Physiologic><Physiological><Pituitary><Pituitary Gland><Pituitary Nervous System><Plasmacytoma Growth Factor><Play><Polyaromatic Hydrocarbon Receptors><Population><Premature Menopause><Proliferating><Public Health><Publishing><RANTES><Replicative Senescence><Reporter><Reproduction><Reproductive Health><Risk><Role><SCYA5><SCYB8><SIS delta><SIS-delta><SISd><Serum><Signal Pathway><Solvents><System><T-Cell RANTES Protein><T-Cell Specific Protein p288><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><TCDD Receptors><TCP228><TSG-1><Testing><Therapeutic Hormone><Time><Tissue Growth><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Turmeric Yellow><Uterus><Woman><Women's Health><Wood><Wood material><Work><adulthood><ages><analyze gene expression><angiogenesis><antagonism><antagonist><b-ENAP><cardiovascular disease risk><cardiovascular disorder risk><child birth><consumer product><cytokine><decreased ovarian reserve><depression><developmental><diminished ovarian reserve><early experience><early menopause><early onset><endocrine disrupting compound><environmental chemical><epidemiology research study><epidemiology study><epidemiology survey><experience><exposed human population><female reproductive body system><female reproductive organ system><female reproductive system><fertility cessation><fertility loss><gene expression analysis><gene expression assay><gynecologic body system><gynecologic organ system><human exposure><human tissue><hypothalamic><improved><infertile><inhibin B><interferon beta 2><kisspeptin><men><mono-(2-ethylhexyl)phthalate><novel><ontogeny><ovarian follicular pool><pathway><personal care products><phthalates><premature age of menopause><primary infertility><protein expression><replicative aging><reproductive><reproductive aging><reproductive cell senescence><reproductive longevity><reproductive senescence><social role><subfertility><thymus derived lymphocyte><transcriptional profiling><womb><♀>

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Romana A. Nowak

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Exploratory lead · 42/100

Likely hiring

Active award

$28,562

FY 2026

Project Title

Phthalate Exposure and Female Reproductive Aging

Grant Number:

3R01ES034112-04S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

10/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

The female reproductive system ages before any other physiological system, making it the most sensitive indicator of aging. Most women experience reproductive senescence around age 51, but many women experience early reproductive aging (early menopause). This is a serious public health problem becau...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><21+ years old><3-10C><AH Receptors><AMCF-I><Acceleration><Acute><Adhesives><Adult><Adult Human><Age><Aging><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Aryl Hydrocarbon Receptor><Assay><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cells><B-Lymphocytes><B-cell><BCDF><BSF-2><BSF2><Binding><Bioassay><Biological Assay><Blood Serum><Body Tissues><CCL5><CD11b><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CR3A><CSIF><CSIF-10><CXCL8><Cannot achieve a pregnancy><Cell Aging><Cell Body><Cell Count><Cell Number><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Cessation of life><Characteristics><Chemokine (C-C Motif) Ligand 5><Childbirth><Chronic><Curcumin><Cytokine Synthesis Inhibitory Factor><Cytotoxic cell><D17S136E><Data><Death><Defoaming Agents><Delayed Childbearing><Development><Diferuloylmethane><Difficulty conceiving><Dioxin Receptors><Disadvantaged><Disease><Disorder><Dose><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine Gland Secretion><Endocrine disrupting agent><Environment><Exposure to><Fecundability><Fecundity><Female><Female Genital System><Female Health><Fertility><Fibrosis><Follicle Stimulating Hormone><Follitropin><Foundations><GCP1><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Greater sac of peritoneum><Growth><HPGF><Health><Hepatocyte-Stimulating Factor><Hormones><Hybridoma Growth Factor><Hypophysis><Hypophysis Cerebri><Hypothalamic structure><Hypothalamus><IFN><IFN-beta 2><IFNB2><IL-10><IL-6><IL-8><IL10><IL10A><IL6 Protein><IL8><IL8 gene><ITGAM><ITGAM gene><Immune><Immunes><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Infertility><Inflammasome><Inflammation><Inflammatory><Interferons><Interleukin 10 Precursor><Interleukin-10><Interleukin-6><K lymphocyte><K60><KISS1><KISS1 Metastasis Suppressor><KISS1 gene><KiSS-1><Lubricants><MAC1A><MEHP><MGC17164><MGC39258><MGI-2><MO1A><Macrophage><Medical Device><Menopausal Symptom><Mental Depression><Metastin><Mice><Mice Mammals><Molecular Interaction><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><NK Cells><Natural Killer Cells><Nuclear Translocator><Osteoporosis><Ovarian Follicle><Ovary><Pathway interactions><Peritoneal Cavity><Peritoneal Macrophages><Pesticides><Physiologic><Physiological><Pituitary><Pituitary Gland><Pituitary Nervous System><Plasmacytoma Growth Factor><Play><Polyaromatic Hydrocarbon Receptors><Population><Premature Menopause><Proliferating><Public Health><Publishing><RANTES><Replicative Senescence><Reporter><Reproduction><Reproductive Health><Risk><Role><SCYA5><SCYB8><SIS delta><SIS-delta><SISd><Serum><Signal Pathway><Solvents><System><T-Cell RANTES Protein><T-Cell Specific Protein p288><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><TCDD Receptors><TCP228><TSG-1><Testing><Therapeutic Hormone><Time><Tissue Growth><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Turmeric Yellow><Uterus><Woman><Women's Health><Wood><Wood material><Work><adulthood><ages><analyze gene expression><angiogenesis><antagonism><antagonist><b-ENAP><cardiovascular disease risk><cardiovascular disorder risk><child birth><consumer product><cytokine><decreased ovarian reserve><depression><developmental><diminished ovarian reserve><early experience><early menopause><early onset><endocrine disrupting compound><environmental chemical><epidemiology research study><epidemiology study><epidemiology survey><experience><exposed human population><female reproductive body system><female reproductive organ system><female reproductive system><fertility cessation><fertility loss><gene expression analysis><gene expression assay><gynecologic body system><gynecologic organ system><human exposure><human tissue><hypothalamic><improved><infertile><inhibin B><interferon beta 2><kisspeptin><men><mono-(2-ethylhexyl)phthalate><novel><ontogeny><ovarian follicular pool><pathway><personal care products><phthalates><premature age of menopause><primary infertility><protein expression><replicative aging><reproductive><reproductive aging><reproductive cell senescence><reproductive longevity><reproductive senescence><social role><subfertility><thymus derived lymphocyte><transcriptional profiling><womb><♀>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

LORI T RAETZMAN

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Exploratory lead · 42/100

Likely hiring

Active award

$28,562

FY 2026

Project Title

Phthalate Exposure and Female Reproductive Aging

Grant Number:

3R01ES034112-04S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

10/31/2027

Why this may be worth a closer look

• Mechanism often supports lab expansion or staff hiring.

Project Abstract

The female reproductive system ages before any other physiological system, making it the most sensitive indicator of aging. Most women experience reproductive senescence around age 51, but many women experience early reproductive aging (early menopause). This is a serious public health problem becau...

Research Terms

<2,3,7,8-Tetrachlorodibenzo-p-dioxin Receptors><21+ years old><3-10C><AH Receptors><AMCF-I><Acceleration><Acute><Adhesives><Adult><Adult Human><Age><Aging><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Aryl Hydrocarbon Receptor><Assay><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cells><B-Lymphocytes><B-cell><BCDF><BSF-2><BSF2><Binding><Bioassay><Biological Assay><Blood Serum><Body Tissues><CCL5><CD11b><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CR3A><CSIF><CSIF-10><CXCL8><Cannot achieve a pregnancy><Cell Aging><Cell Body><Cell Count><Cell Number><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Cessation of life><Characteristics><Chemokine (C-C Motif) Ligand 5><Childbirth><Chronic><Curcumin><Cytokine Synthesis Inhibitory Factor><Cytotoxic cell><D17S136E><Data><Death><Defoaming Agents><Delayed Childbearing><Development><Diferuloylmethane><Difficulty conceiving><Dioxin Receptors><Disadvantaged><Disease><Disorder><Dose><Endocrine Disrupter><Endocrine Disrupting Chemicals><Endocrine Disruptors><Endocrine Gland Secretion><Endocrine disrupting agent><Environment><Exposure to><Fecundability><Fecundity><Female><Female Genital System><Female Health><Fertility><Fibrosis><Follicle Stimulating Hormone><Follitropin><Foundations><GCP1><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Greater sac of peritoneum><Growth><HPGF><Health><Hepatocyte-Stimulating Factor><Hormones><Hybridoma Growth Factor><Hypophysis><Hypophysis Cerebri><Hypothalamic structure><Hypothalamus><IFN><IFN-beta 2><IFNB2><IL-10><IL-6><IL-8><IL10><IL10A><IL6 Protein><IL8><IL8 gene><ITGAM><ITGAM gene><Immune><Immunes><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Infertility><Inflammasome><Inflammation><Inflammatory><Interferons><Interleukin 10 Precursor><Interleukin-10><Interleukin-6><K lymphocyte><K60><KISS1><KISS1 Metastasis Suppressor><KISS1 gene><KiSS-1><Lubricants><MAC1A><MEHP><MGC17164><MGC39258><MGI-2><MO1A><Macrophage><Medical Device><Menopausal Symptom><Mental Depression><Metastin><Mice><Mice Mammals><Molecular Interaction><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><NK Cells><Natural Killer Cells><Nuclear Translocator><Osteoporosis><Ovarian Follicle><Ovary><Pathway interactions><Peritoneal Cavity><Peritoneal Macrophages><Pesticides><Physiologic><Physiological><Pituitary><Pituitary Gland><Pituitary Nervous System><Plasmacytoma Growth Factor><Play><Polyaromatic Hydrocarbon Receptors><Population><Premature Menopause><Proliferating><Public Health><Publishing><RANTES><Replicative Senescence><Reporter><Reproduction><Reproductive Health><Risk><Role><SCYA5><SCYB8><SIS delta><SIS-delta><SISd><Serum><Signal Pathway><Solvents><System><T-Cell RANTES Protein><T-Cell Specific Protein p288><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><TCDD Receptors><TCP228><TSG-1><Testing><Therapeutic Hormone><Time><Tissue Growth><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Turmeric Yellow><Uterus><Woman><Women's Health><Wood><Wood material><Work><adulthood><ages><analyze gene expression><angiogenesis><antagonism><antagonist><b-ENAP><cardiovascular disease risk><cardiovascular disorder risk><child birth><consumer product><cytokine><decreased ovarian reserve><depression><developmental><diminished ovarian reserve><early experience><early menopause><early onset><endocrine disrupting compound><environmental chemical><epidemiology research study><epidemiology study><epidemiology survey><experience><exposed human population><female reproductive body system><female reproductive organ system><female reproductive system><fertility cessation><fertility loss><gene expression analysis><gene expression assay><gynecologic body system><gynecologic organ system><human exposure><human tissue><hypothalamic><improved><infertile><inhibin B><interferon beta 2><kisspeptin><men><mono-(2-ethylhexyl)phthalate><novel><ontogeny><ovarian follicular pool><pathway><personal care products><phthalates><premature age of menopause><primary infertility><protein expression><replicative aging><reproductive><reproductive aging><reproductive cell senescence><reproductive longevity><reproductive senescence><social role><subfertility><thymus derived lymphocyte><transcriptional profiling><womb><♀>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Andrei Seluanov

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Exploratory lead · 40/100

Above-average budget

Recent

Active award

$693,002

FY 2026

Project Title

Regulation of epigenome stability by SIRT6 during Aging

Grant Number:

5R37AG046320-13

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2014

End Date:

2/28/2029

Why this may be worth a closer look

• Award size is strong enough to merit immediate review.

Project Abstract

The long-term goal of this project is to define the molecular mechanisms which regulate epigenome stability during aging and the role of the mammalian sirtuin, SIRT6, in this process. Growing evidence indicates that epigenome structure becomes compromised with age which may be the root cause of age-...

Research Terms

<100+ years old><170-kD Gene BRG1-Associated Factor><ADP ribosylation><ATAC sequencing><ATAC-seq><ATACseq><Affect><Age><Age related pathologies><Aging><Amino Acids><Antibodies><Applications Grants><Architecture><Assay for Transposase-Accessible Chromatin using sequencing><Attenuated><Automobile Driving><BAF170 Gene><BRG-1><BRG-1 Gene><BRG1><BRG1 Gene><BRM/SWI2-Related Gene-1><Back><Biochemical><Biological Function><Biological Process><C-jun Amino-Terminal Kinase><C-jun Kinase-1><C-jun N-Terminal Kinase 1><CRACC2 Gene><Cell Aging><Cell Body><Cell Culture Techniques><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Centenarian><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin><Chromatin Remodeling Complex BAF170 Subunit Gene><DNA><DNA Damage><DNA Damage Repair><DNA Double Strand Break><DNA Injury><DNA Repair><DNA Transposable Elements><DNA mutation><Data><Deacetylase><Deacetylation><Deoxyribonucleic Acid><Deterioration><Dorsum><Double Strand Break Repair><Engineering / Architecture><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Expression Signature><Funding><Gene Expression Profile><Gene Transcription><Genes><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Genome Instability><Genome Stability><Genomic Instability><Genomic Stability><Glycolysis><Goals><Grant Proposals><GrimAge clock><Hannum clock><Health><Hi-C><Histone H1><Histones><Horvath clock><Immunofluorescence><Immunofluorescence Immunologic><In Situ><In Vitro><Increase lifespan><Inflammation><JN Kinase><JNK><JNK Mitogen-Activated Protein Kinases><JNK1><JNK1 Kinase><JNK1 protein><JNK1A2><JNK21B1/2><KI mice><KO mice><Knock-in Mouse><Knock-out Mice><Knockout Mice><Laboratories><Length of Life><Life><Link><Longevity><MAP Kinase 8><MAP Kinase 8 Gene><MAPK8><MAPK8 Mitogen-Activated Protein Kinase><MAPK8 gene><Maintenance><Mammalian Chromatin Remodeling Complex, BRG1-Associated Factor 170 Gene><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Mice><Mice Mammals><Mitogen-Activated Protein Kinase 8><Modification><Molecular><Murine><Mus><Mutate><Mutation><Nucleosomes><Null Mouse><Oncogenesis><Organ><Oxidative Stress><PRKM8><Pathway interactions><Pattern><Peptides><PhenoAge clocks><Phenotype><Phosphorylation><Position><Positioning Attribute><Prevention><Process><Protein Phosphorylation><Proteins><RNA Expression><Regulation><Replicative Senescence><Repression><Research><Resistance><Role><SAP Kinase-1><SAPK/JNK><SAPK1 Mitogen-Activated Protein Kinase><SAPK1/JNK><SMARCA4><SMARCA4 gene><SMARCC2><SMARCC2 gene><SNF2-Beta><SWI/SNF Complex 170 kDa Subunit Gene><SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily A, Member 4 Gene><SWI/SNF-Related, Matrix-Associated, Actin-Dependent Regulator of Chromatin, Subfamily C, Member 2 Gene><SWI3-Like Protein Gene><Silent Mating Type Information Regulator 2-like Proteins><Sir2-like Proteins><Sirtuins><Site><Stress><Stress-Activated Protein Kinase JNK1><Stress-Activated Protein Kinase gamma><Structure><Subcellular Process><Telomere Maintenance><Testing><Therapeutic><Transcription><Transposable Elements><Unscheduled DNA Synthesis><Variant><Variation><Work><age associated decline><age associated disease><age associated disorder><age associated impairment><age associated pathologies><age dependent decline><age dependent disease><age dependent disorder><age dependent impairment><age dependent pathologies><age induced pathologies><age related decline><age related human disease><age-related disease><age-related disorder><age-related impairment><ages><aging associated pathologies><aging dependent pathologies><aging induced pathologies><aging pathologies><aging process><aging related pathologies><aminoacid><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><attenuate><attenuates><boost longevity><c-jun N-Terminal Kinase><cell culture><cell cultures><centenarian human (100+)><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><decline with age><design><designing><driving><elongating the lifespan><enhance longevity><epigenetic age clocks><epigenetic clock><epigenetic molecular clocks><epigenetically><epigenome><epigenomics><experiment><experimental research><experimental study><experiments><extend life span><extend lifespan><extend longevity><foster longevity><gene expression pattern><gene expression signature><genome mutation><healthspan><healthy life span><improve lifespan><improve longevity><in vivo><insight><jun-NH2-Terminal Kinase><knockin mice><life span><lifespan><lifespan extension><methylation clock><mouse model><murine model><mutant><novel><overexpress><overexpression><pathway><prolong lifespan><prolong longevity><promote lifespan><promote longevity><promoter><promotor><recruit><replicative aging><resistant><response><senescence><senescent><senescent cell><social role><stress-activated protein kinase 1><support longevity><transcriptional profile><transcriptional signature><tumorigenesis>

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Erzsebet Regan

COLLEGE OF WOOSTER, WOOSTER, OH

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$482,620

FY 2026

Project Title

Regulatory Network Modeling of Cellular Transitions in Aging Epithelia and Capillaries

Grant Number:

1R15AG083621-01A1

Activity Code:

R15

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2029

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY During epithelial wound healing, senescence makes short-term use of damaged cells by blocking their division while they boost survival, proliferation, and migration in their neighbors. Meanwhile, partial Epithelial to Mesenchymal Transition (EMT) creates migrating and proliferating c...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Age><Aging><Alveolar><Assay><Assistantship><Autoregulation><Behavior><Bioassay><Biologic Sciences><Biological Assay><Biological Sciences><Biomechanics><Biomedical Research><Bioscience><Birth><Blood capillaries><Body Tissues><COPD><Cardiac infarction><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Senescence Induction><Cell Signaling><Cell model><Cells><Cellular Proliferation><Cellular injury><Cellular model><Cessation of life><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Collaborations><Computational Biology><Computational toolkit><Computer Models><Computer software><Computerized Models><Cues><Curriculum><DNA Damage><DNA Injury><DNA mutation><Darkness><Data><Data Bases><Databases><Death><Development><Disease><Disorder><Drug Therapy><Educational Curriculum><Embryo Development><Embryogenesis><Embryonic Development><Emphysema><Endothelial Cells><Endothelium><Environment><Epithelial Cells><Epithelium><Event><Experimental Models><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Friends><Funding><Generalized Growth><Genetic Change><Genetic defect><Genetic mutation><Goals><Growth><Healing abnormal><Healing delayed><Health><Homeostasis><Hybrids><Impaired healing><Impaired tissue repair><Impaired wound healing><Impairment><In Vitro><Individual><Intervention><Intracellular Communication and Signaling><Invaded><Knowledge><Learning><Life Sciences><Link><Literature><Lung><Lung Respiratory System><M cell><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mesenchymal><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Microscopy><Mission><Modeling><Molecular><Mutation><Myocardial Infarct><Myocardial Infarction><NIH><National Institutes of Health><Neoplasm Metastasis><Parturition><Pathologic Angiogenesis><Pathologic Neovascularization><Pathological Angiogenesis><Pathological Neovascularization><Pathway interactions><Pattern><Pattern Formation><Pharmacological Treatment><Pharmacotherapy><Physiological Homeostasis><Predisposition><Process><Progressive Disease><Proliferating><Public Health><Publishing><Pulmonary Cancer><Pulmonary Emphysema><Pulmonary malignant Neoplasm><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><Research><Role><Secondary Neoplasm><Secondary Tumor><Side><Signal Transduction><Signal Transduction Systems><Signaling><Site><Software><Speed><Structure><Students><Susceptibility><Testing><Therapeutic><Tissue Growth><Tissue Model><Tissues><Training><Translating><United States National Institutes of Health><Validation><Vascular Diseases><Vascular Disorder><Work><Wound Repair><abnormal tissue repair><adulthood><age associated><age associated effects><age correlated><age dependent><age effect><age linked><age related><age related effects><age related pathways><age specific><ages><aging associated disease><aging associated disorders><aging associated mechanism><aging effect><aging mechanism><aging pathway><aging related disease><aging related disorders><aging related mechanism><aging related pathways><angiogenesis><biological mechanism of age><biological pathways of age><biological signal transduction><biomechanical><blood vessel disorder><cancer metastasis><capillary><cardiac infarct><cell behavior><cell community><cell damage><cell injury><cellular aging induction><cellular behavior><cellular community><cellular damage><cellular senescence induction><chronic obstructive pulmonary disorder><chronic skin wound><chronic wound><college><collegiate><computational modeling><computational models><computational network modeling><computational toolbox><computational tools><computational toolset><computer based models><computer biology><computerized modeling><computerized tools><coronary attack><coronary infarct><coronary infarction><cost><damage to cells><data base><delayed wound healing><design><designing><developmental><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><drug intervention><drug treatment><effective intervention><emphysematous><epithelial injury><epithelial to mesenchymal transition><epithelial wound><experiment><experimental research><experimental study><experiments><flow cytophotometry><genome mutation><healing><heart attack><heart infarct><heart infarction><immune clearance><immune elimination><impact of age><in silico><influence of age><injury to cells><innovate><innovation><innovative><lab experience><lab training><laboratory experience><laboratory training><lesson plans><lung cancer><mechanism regulating aging><mechanisms involved in aging><migration><multi-scale computational modeling><multi-scale mathematical modeling><multi-scale modeling><multiscale computational modeling><multiscale mathematical modeling><multiscale modeling><network models><new approaches><novel approaches><novel strategies><novel strategy><ontogeny><pathway><pathway involved in aging><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phenotypic data><preservation><qRTPCR><re-epithelialization><response><scRNA sequencing><scRNA-seq><scaffold><scaffolding><senescence><senescence induction><senescent><senescent cell><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><tissue wound><tool><tumor><tumor cell metastasis><undergrad><undergraduate><undergraduate research><undergraduate research experience><undergraduate research opportunities><undergraduate research programs><undergraduate student><validations><vascular dysfunction><vasculopathy><wound><wound healing><wound recovery><wound resolution><wounding><wounds>

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Susan C. Alberts

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$389,076

FY 2026

Project Title

Research Network on Animal Models to Understand Social Dimensions of Aging

Grant Number:

5R24AG065172-07

Activity Code:

R24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2020

End Date:

2/28/2030

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary As the population of the United States ages, the health burden imposed by diseases of aging is expected to increase concomitantly. Social factors, including low socioeconomic status, social isolation, and low social support, are among the best predictors of susceptibility to diseases...

Research Terms

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Alessandro Bartolomucci

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$389,076

FY 2026

Project Title

Research Network on Animal Models to Understand Social Dimensions of Aging

Grant Number:

5R24AG065172-07

Activity Code:

R24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2020

End Date:

2/28/2030

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary As the population of the United States ages, the health burden imposed by diseases of aging is expected to increase concomitantly. Social factors, including low socioeconomic status, social isolation, and low social support, are among the best predictors of susceptibility to diseases...

Research Terms

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Kathleen Mullan Harris

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$389,076

FY 2026

Project Title

Research Network on Animal Models to Understand Social Dimensions of Aging

Grant Number:

5R24AG065172-07

Activity Code:

R24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2020

End Date:

2/28/2030

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary As the population of the United States ages, the health burden imposed by diseases of aging is expected to increase concomitantly. Social factors, including low socioeconomic status, social isolation, and low social support, are among the best predictors of susceptibility to diseases...

Research Terms

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Noah Snyder-Mackler

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 40/100

Solid budget

Very recent

Active award

$389,076

FY 2026

Project Title

Research Network on Animal Models to Understand Social Dimensions of Aging

Grant Number:

5R24AG065172-07

Activity Code:

R24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

3/1/2020

End Date:

2/28/2030

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary As the population of the United States ages, the health burden imposed by diseases of aging is expected to increase concomitantly. Social factors, including low socioeconomic status, social isolation, and low social support, are among the best predictors of susceptibility to diseases...

Research Terms

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Jack You

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$55,114

FY 2026

Project Title

Investigating the Mechanisms of Hair Progenitor Cell Activation and Aging Resistance Through SOX5

Grant Number:

1F30AG099347-01

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary Adult tissue homeostasis depends on the tightly regulated activity of tissue-resident stem and progenitor cells. With age, this regenerative capacity declines due to impaired progenitor function, contributing to tissue dysfunction and degeneration. One of the most striking examples o...

Research Terms

<21+ years old><6 year old><6 years of age><Address><Adeno-Associated Viruses><Adult><Adult Human><Age><Aging><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Body Tissues><CUT&RUN><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Signaling><Cells><Cellular Proliferation><Chondrocytes><Cleavage Targets and Release Using Nuclease><Cleavage Under Targets and Release Using Nuclease><Data><Dependoparvovirus><Dependovirus><Disease><Disorder><Dorsal><Dysfunction><Enhancer-Binding Protein GATA3><Epidermis><Exhibits><Functional disorder><GATA-3 factors><GATA-3 protein><GATA-Binding Protein 3><GATA3><GATA3 gene><GATA3 protein><GATA3 transcription factor><Gametes><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Genetic><Genetic Transcription><Germ><Germ Cells><Germ-Line Cells><Growth><Hair><Hair Follicle><Hair follicle structure><Homeostasis><Human><Immunoblotting><Immunofluorescence><Immunofluorescence Immunologic><Impairment><In Vitro><Intracellular Communication and Signaling><L-SOX5><Length><Life><Long SOX5><Maintenance><Measures><Mice><Mice Mammals><Miniaturisations><Miniaturization><Modeling><Modern Man><Molecular><Morphology><Murine><Mus><Natural regeneration><Neural Stem Cell><Non-Polyadenylated RNA><Organ><Organ Culture><Organ Culture Techniques><Organism><Output><Pathway interactions><Phase><Phenotype><Physiological Homeostasis><Physiopathology><Play><Process><Progenitor Cells><Proliferating><RNA><RNA Expression><RNA Gene Products><Regeneration><Regenerative capacity><Reproductive Cells><Resistance><Rest><Ribonucleic Acid><Role><SOX5><SOX5 gene><SRY-Box 5><SRY-Related HMG-Box Gene 5><Scalp><Scalp structure><Serotyping><Sex Cell><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Skin><Specific qualifier value><Specified><Staining method><Stains><Structure><Study models><System><Testing><Therapeutic><Time><Tissue Growth><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transgenic Organisms><Western Blotting><Western Immunoblotting><Width><Work><adeno associated virus group><adulthood><age 6><age 6 years><age associated><age correlated><age dependent><age linked><age related><age reversal><age specific><aged><aged mice><aged mouse><ages><aging associated><aging related><aging reversal><alleviate age related><alleviate aging><ameliorating aging><biological signal transduction><cell type><clinical relevance><clinically relevant><combat><counter age related><counter aging><counteract age related><counteract aging><elderly mice><hair regeneration><improved><in vitro Organ Culturing><in vitro vertebrate organ culturing><initial cell><keratinocyte><living system><mid life><mid-life><middle age><middle aged><midlife><mouse model><murine model><nerve stem cell><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new approaches><novel approaches><novel strategies><novel strategy><old mice><ontogeny><overexpress><overexpression><pathophysiology><pathway><postnatal><prevent><preventing><progenitor><progenitor and neural stem cells><progenitor cell differentiation><progenitor cell function><progenitor cell pool><progenitor cell population><progenitor cell proliferation><progenitor differentiation><progenitor function><progenitor pool><progenitor population><progenitor proliferation><programs><protein blotting><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration ability><regeneration based therapy><regeneration capacity><regeneration therapy><regenerative><regenerative therapeutics><regenerative therapy><repair><repaired><resistant><reverse age><reverse aging><reverse aging effects><reversible aging><scRNA sequencing><scRNA-seq><self-renew><self-renewal><senescent cell><sexual cell><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell next generation sequencing><single cell sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><six year old><six years of age><social role><stem><stem and progenitor cell function><stem and progenitor cell population><stem and progenitor cell proliferation><stem and progenitor differentiation><stem and progenitor function><stem cell differentiation><stem cell function><stem cell pool><stem cell population><stem cell proliferation><stem cells><tissue degeneration><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcription factor><transgenic>

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Maggie Marie Kane

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 40/100

Training-friendly

Recent

Active award

$50,114

FY 2026

Project Title

Mechanisms of NBR2, a Long Non-Coding RNA, in Human Ovarian Aging

Grant Number:

1F31AG099640-01

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2029

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT This research proposal is in response to the NOT-OD-24-079 “Notice of Special Interest: Women’s Health Research” focused on health conditions that are female-specific. The ovary is the first organ to age in the human body. Ovarian aging negatively influences lifespan and a b...

Research Terms

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Susan Nicole Hastings

EDITH NOURSE ROGERS MEMORIAL VETERANS HOSPITAL, BEDFORD, MA

Exploratory lead · 38/100

Very recent

Active award

Team-scale grant

$0

FY 2026

Project Title

Caregiving/Long Term Care/Aging COR

Grant Number:

1I50RD000608-01A1

Activity Code:

I50

Mechanism:

Research Centers

Agency:

VA

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Background and Significance: In primary partnership with the Office of Geriatrics and Extended Care (GEC), Geriatrics and Extended care-focused Network to Enhance Research Across The Enterprise (GENERATE) has three priority areas in which it will support advancement: (1) Home care workforce and fami...

Research Terms

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William W.,MPH, MD Hung

EDITH NOURSE ROGERS MEMORIAL VETERANS HOSPITAL, BEDFORD, MA

Exploratory lead · 38/100

Very recent

Active award

Team-scale grant

$0

FY 2026

Project Title

Caregiving/Long Term Care/Aging COR

Grant Number:

1I50RD000608-01A1

Activity Code:

I50

Mechanism:

Research Centers

Agency:

VA

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Background and Significance: In primary partnership with the Office of Geriatrics and Extended Care (GEC), Geriatrics and Extended care-focused Network to Enhance Research Across The Enterprise (GENERATE) has three priority areas in which it will support advancement: (1) Home care workforce and fami...

Research Terms

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Whitney L Mills

EDITH NOURSE ROGERS MEMORIAL VETERANS HOSPITAL, BEDFORD, MA

Exploratory lead · 38/100

Very recent

Active award

Team-scale grant

$0

FY 2026

Project Title

Caregiving/Long Term Care/Aging COR

Grant Number:

1I50RD000608-01A1

Activity Code:

I50

Mechanism:

Research Centers

Agency:

VA

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Background and Significance: In primary partnership with the Office of Geriatrics and Extended Care (GEC), Geriatrics and Extended care-focused Network to Enhance Research Across The Enterprise (GENERATE) has three priority areas in which it will support advancement: (1) Home care workforce and fami...

Research Terms

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Camilla Benedicto Pimentel

EDITH NOURSE ROGERS MEMORIAL VETERANS HOSPITAL, BEDFORD, MA

Exploratory lead · 38/100

Very recent

Active award

Team-scale grant

$0

FY 2026

Project Title

Caregiving/Long Term Care/Aging COR

Grant Number:

1I50RD000608-01A1

Activity Code:

I50

Mechanism:

Research Centers

Agency:

VA

Start Date:

3/1/2026

End Date:

2/28/2031

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Background and Significance: In primary partnership with the Office of Geriatrics and Extended Care (GEC), Geriatrics and Extended care-focused Network to Enhance Research Across The Enterprise (GENERATE) has three priority areas in which it will support advancement: (1) Home care workforce and fami...

Research Terms

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Sebastian Cruz Gonzalez

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 34/100

Training-friendly

Active award

$47,390

FY 2026

Project Title

The Influence of Admixture on Biological Aging in the Context of Alzheimer’s Disease

Grant Number:

5F31AG090006-02

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY Biological aging is the process through which living things accumulate genetic damage, degenerate, and eventually die. Aging manifests itself through the loss of proteostasis, cellular senescence, telomere attrition, genomic instability, among other molecular effects. Various factors...

Research Terms

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Mary Kramer

UNIVERSITY OF DELAWARE, Newark, DE

Exploratory lead · 34/100

Training-friendly

Active award

$46,230

FY 2026

Project Title

In Vivo Evaluation of Brain Tissue Integrity in Aging Using a Novel Magnetic Resonance Elastography Technique

Grant Number:

5F31AG086036-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2026

Why this may be worth a closer look

• Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY This project includes both the development of advanced MRI sequences to study brain stiffness as well as clinical application of this technique to study brain health in an aging adult population. A sensitive method to establish and reliably detect the point where the progression of A...

Research Terms

<0-11 years old><21+ years old><AD dementia><Acceleration><Address><Adult><Adult Human><Advanced Development><Affect><Aging><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><American><Atrophic><Atrophy><Birth Rate><Body Tissues><Brain><Brain Mapping><Brain Nervous System><Brain region><Cardiac><Cell Communication and Signaling><Cell Signaling><Censuses><Cerebrovascular Circulation><Child><Child Youth><Children (0-21)><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Creativeness><Data><Data Analyses><Data Analysis><Dementia><Development><Diagnosis><Disease><Disorder><Disturbance in cognition><Early Diagnosis><Early Intervention><Encephalon><Equipment><Estimation Techniques><Evaluation><Financial Hardship><Frequencies><Health Care Systems><History><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Impaired cognition><In vivo analysis><Individual><Infrastructure><Intervention><Intracellular Communication and Signaling><Length of Life><Longevity><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Elastography><Magnetic Resonance Imaging><Measures><Mechanics><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Motion><NMR Imaging><NMR Tomography><Neurologic><Neurological><Noise><Nuclear Magnetic Resonance Imaging><Participant><Pathologic><Patients><Phase><Population><Position><Positioning Attribute><Primary Senile Degenerative Dementia><Public Health><Recording of previous events><Research><Research Resources><Resolution><Resources><Sampling><Scanning><Scheme><Signal Transduction><Signal Transduction Systems><Signaling><Source><Special Equipment><Speed><System><Techniques><Technology><Therapeutic Intervention><Time><Tissues><United States><Validation><Work><Zeugmatography><aberrant aging><abnormal aging><adult youth><adulthood><age associated><age associated dementia><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age correlated><age dependent><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age induced dementia><age linked><age related><age related dementia><age related neurodegeneration><age specific><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><aging associated><aging associated dementia><aging associated disease><aging associated disorders><aging associated neurodegeneration><aging associated neurodegenerative disease><aging related><aging related dementia><aging related disease><aging related disorders><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><biological signal transduction><blood flow in brain><brain blood circulation><brain blood flow><brain health><brain tissue><burden of disease><burden of illness><care costs><cerebral blood flow><cerebral circulation><cerebrocirculation><cerebrovascular blood flow><clinical applicability><clinical application><cognitive dysfunction><cognitive loss><cognitive performance><cohort><creativity><data acquisition><data acquisitions><data interpretation><data quality><demographics><developmental><disease associated with aging><disease burden><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><dysfunctional age related change><dysfunctional aging><early detection><economic hardship><economic security><economic self-sufficiency><economic stability><economic strain><economic well-being><elastic imaging><elasticity imaging><elastography><experience><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial security><financial stability><financial strain><financial stress><financial well-being><financial worry><flexibility><flexible><histories><imaging><imaging in vivo><impaired aging><improved><in vivo><in vivo evaluation><in vivo imaging><in vivo testing><insight><interest><intervention therapy><kids><maladaptive aging><mechanic><mechanical><mechanical properties><natural aging><neural imaging><neuro-imaging><neuroimaging><neurological imaging><normal aging><normative aging><novel><older adult><older adulthood><pathological age related changes><pathological aging><primary degenerative dementia><reconstruction><research study><resolutions><response><senile dementia of the Alzheimer type><spatial and temporal><spatial temporal><spatiotemporal><success><tissue map><tissue mapping><validations><vibration><young adult><young adult age><young adulthood><youngster>

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Lezi E

MEDICAL COLLEGE OF WISCONSIN, MILWAUKEE, WI

Exploratory lead · 32/100

Solid budget

Recent

Active award

$429,000

FY 2026

Project Title

Defining the Role of Hsa21 Gene Overexpression in Aging-Associated and Aβ-Induced Neurodegeneration in C. elegans

Grant Number:

1R21AG098616-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Down syndrome (DS), caused by an extra copy of chromosome 21 (Hsa21), is the most common genetic cause of intellectual disability and is also strongly linked to dementia. About 75% of DS individuals eventually develop Alzheimer’s disease (AD)-like symptoms, with amyloid-beta (Aβ) pla...

Research Terms

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Gretchen A Meyer

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 32/100

Solid budget

Recent

Active award

$427,625

FY 2026

Project Title

Targeting Intramuscular Adipose Quality in Aging

Grant Number:

1R21AG091159-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Typical aging features progressive muscle weakness and loss of physical ability which impacts quality of life for millions of Americans. Beyond loss of lean muscle mass, muscle weakness and physical dysfunction are strongly associated with increasing ectopic adipose within the muscle...

Research Terms

<1,2,3-Propanetriol><1,2,3-Trihydroxypropane><20 year old><20 years of age><21+ years old><Address><Adipocytes><Adipose Cell><Adipose tissue><Adjuvant Therapy><Adult><Adult Human><Age><Aging><American><Ankle><Biology of Aging><Biopsy><Body Tissues><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cell Signaling><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Chronic Care><Chronic Disease><Chronic Illness><Development><Diabetes Mellitus><Drug Therapy><Dysfunction><Environment><Exercise><Exercise Therapy><Exhibits><Experimental Models><Fat Cells><Fatty Tissue><Flexor><Functional disorder><Future><Gastrocnemius Muscle><Gene Transcription><Genetic Transcription><Glycerin><Glycerol><Goals><Health><Hindlimb><Histologic><Histologically><Human><Impairment><Independent Living><Individual><Inflammatory><Injections><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><Intramuscular><Investigation><Knowledge><Leanness><Link><Lipocytes><Mature Lipocyte><Mature fat cell><Medical Rehabilitation><Metabolic Processes><Metabolic syndrome><Metabolism><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Muscle><Muscle Atrophy><Muscle Cell Contraction><Muscle Contraction><Muscle Fibers><Muscle Tissue><Muscle Weakness><Muscle function><Muscular Atrophy><Muscular Contraction><Muscular Weakness><Myotubes><Obesity><Paracrine Communication><Paracrine Signaling><Participant><Pathologic><Pathology><Persons><Pharmacological Treatment><Pharmacology><Pharmacotherapy><Phenotype><Physical Function><Physiopathology><Population><Pre-Clinical Model><Preclinical Models><Prognosis><QOL><Quality of life><RNA Expression><Regio tarsalis><Rehabilitation><Rehabilitation therapy><Replicative Senescence><Research><Resistance><Rhabdomyocyte><Rodent><Rodentia><Rodents Mammals><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Subcellular Process><System><Testing><Therapeutic exercise><Thinness><Tissue Model><Tissues><Toxin><Training><Transcription><Visceral><Voluntary Muscle><Work><adipose><adiposity><adjuvant treatment><adulthood><age 20><age 20 years><age associated alterations><age associated changes><age associated effects><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age effect><age group><age induced alterations><age induced changes><age related alterations><age related changes><age related effects><age specific alterations><age specific changes><aged><aged mice><aged mouse><aged muscle><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging of muscle><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><biological signal transduction><cellular targeting><changes with age><chronic disorder><corpulence><developmental><diabetes><diet and exercise><disability risk><drug intervention><drug treatment><elderly mice><enhance healthspan><exercise program><exercise treatment><experiment><experimental research><experimental study><experiments><extend healthspan><extending healthy lifespan><fitness program><gastrocnemius><health care burden><healthspan extension><human data><human tissue><impact of age><improve healthspan><improved><increase healthspan><influence of age><insight><interest><life span><lifespan><mouse model><murine model><muscle aging><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle strengthening><muscle wasting><muscular><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><non-invasive imaging><noninvasive imaging><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><old mice><older adult><older adulthood><pathophysiology><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><prolong healthspan><promote healthspan><rehab therapy><rehabilitation care><rehabilitative><rehabilitative care><rehabilitative therapy><replicative aging><resistance exercise><resistance training><resistant><response><senescence><senescent><strength training><subcutaneous><subdermal><success><synergism><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic target><tool><transcriptomics><treated with exercise><twenty year old><twenty years of age><ultrasound><white adipose tissue><yellow adipose tissue>

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Tina E Brinkley

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Exploratory lead · 32/100

Solid budget

Recent

Active award

$426,250

FY 2026

Project Title

Vibegron: A Novel Treatment for Multisystem Functional Decline in Aging and Obesity

Grant Number:

1R21AG091075-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Aging is characterized by the gradual loss of physiological integrity, and this process may be accelerated in the presence of obesity, increasing susceptibility to disease, frailty, and death. Although the shared molecular pathways involved have not been fully elucidated, adipose tis...

Research Terms

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Peter van Galen

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 32/100

Solid budget

Recent

Active award

$268,500

FY 2026

Project Title

Integrative Single-Cell Analysis of Aging-Associated Changes in Human Hematopoietic Stem Cell Heterogeneity

Grant Number:

1R21HL184189-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT The global population is aging rapidly, with the number of people over 65 expected to double by 2050. Aging alters hematopoietic stem cells (HSCs), leading to increased inflammation, immune dysfunction, and clonal hematopoiesis. These changes have been linked to hematologica...

Research Terms

<(TNF)-α><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AP-1><AP-1 Enhancer-Binding Protein><AP1><AP1 protein><Acceleration><Activator Protein-1><Active Follow-up><Address><Age><Aged 65 and Over><Aging><Algorithms><Automobile Driving><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Blood><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Body Tissues><Cachectin><Cancers><Cardiovascular Diseases><Cell Body><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Signaling><Cells><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Communities><Complex><Consensus><Data><Data Set><Development><Differential Gene Expression><Disease><Disorder><Dysfunction><Enhancer-Binding Protein AP1><Exhibits><Foundations><Functional disorder><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><General Transcription Factor Gene><General Transcription Factors><Genes><Goals><HSC aging><HSC heterogeneity><HSC quiescence><HSC subsets><Health><Heart><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell heterogeneity><Hematopoietic Stem Cell subsets><Hematopoietic progenitor subsets><Hematopoietic stem cells><Heterogeneity><Homeostasis><Human><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunes><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Increase lifespan><Individual><Infection><Inflammation><Inflammatory><Intervention><Intracellular Communication and Signaling><Investigators><Knowledge><Laboratories><Link><Lung><Lung Diseases><Lung Respiratory System><Macrophage-Derived TNF><Malignant Neoplasms><Malignant Tumor><Meta-Analysis><Mission><Modern Man><Molecular><Monocyte-Derived TNF><Myeloid Progenitor><Myeloid Progenitor Cells><Myeloid Stem Cells><NHLBI><NIH><National Heart, Lung, and Blood Institute><National Institutes of Health><Organism><Outcome><Pathway interactions><Persons><Physiological Homeostasis><Physiopathology><Population><Preparation><Proliferating><Public Health><Pulmonary Diseases><Pulmonary Disorder><Reproducibility><Research><Research Personnel><Researchers><Resolution><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><System><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Technology><Testing><Therapeutic Intervention><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Transcription Factor AP-1><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><United States National Institutes of Health><Work><above age 65><active followup><advanced analytics><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age associated alterations><age associated changes><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age linked><age of 65 years onward><age related><age related alterations><age related changes><age specific><age specific alterations><age specific changes><aged><aged 65 and greater><aged 65+><aged ≥65><ages><aging associated><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><analyze gene expression><biological signal transduction><biological systems><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell heterogeneity><blood stem cell quiescence><blood-forming stem cell><boost longevity><cardiac repair><cardiovascular disorder><cardiovascular risk><cardiovascular risk factor><cell type><changes with age><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><community empowerment><computational pipelines><cytokine><developmental><differential expression><differentially expressed><discover genes><disease of the lung><disorder of the lung><driving><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><fitness><follow up><follow-up><followed up><followup><foster longevity><gene conservation><gene discovery><gene expression analysis><gene expression assay><heart repair><hematopoietic cell clones><hematopoietic progenitor><hematopoietic stem cell aging><hematopoietic stem cell clonality><hematopoietic stem cell quiescence><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><heterogeneity within hematopoietic stem cells><heterogeneous blood stem cells><heterogeneous hematopoietic stem cells><human data><human old age (65+)><improve lifespan><improve longevity><improved><innovate><innovation><innovative><insight><intervention therapy><lifespan extension><living system><lung disorder><malignancy><member><mouse model><murine model><myeloid precursor><myeloid stem and progenitor cell><neoplasm/cancer><next generation><over 65 years><pathophysiology><pathway><preparations><progenitor biology><progenitor cell biology><progenitor cell pool><progenitor cell population><progenitor pool><progenitor population><programs><prolong lifespan><prolong longevity><promote lifespan><promote longevity><quantification of aging><resolutions><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><stem and progenitor biology><stem and progenitor cell population><stem cell biology><stem cell pool><stem cell population><support longevity><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><transcription factor><transcriptional differences><transcriptional profiling><transcriptomics><≥65 years>

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AMANDA L SHARPE

OKLAHOMA MEDICAL RESEARCH FOUNDATION, OKLAHOMA CITY, OK

Exploratory lead · 32/100

Solid budget

Recent

Active award

$253,666

FY 2026

Project Title

Cell-type specific role of melanocortin 4 receptor in inflammation and cognition with aging

Grant Number:

7R21AG093578-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

5/31/2027

Project Abstract

Low-grade, chronic inflammation (“inflammaging”) is a pillar of aging, with neuroinflammation in the hippocampus associated with decreased cognitive ability and decreased lifespan. Feeding rodents a high fat diet (HFD) mimics the neuroinflammation, shortened lifespan, and compromised cognitive abili...

Research Terms

<(TNF)-α><AD dementia><Abbreviations><Abscission><Age><Age Months><Aging><Agonist><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimers Dementia><Ammon Horn><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Anxiety><Astrocytes><Astrocytus><Astroglia><Attention><Automobile Driving><Autoregulation><Aβ><Behavioral><Body Weight><Brain><Brain Nervous System><CNS plasticity><Cachectin><Chronic><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Cornu Ammonis><Data><Development><Disseminated Sclerosis><Disturbance in cognition><Encephalon><Excision><Extirpation><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Gene Transcription><Genetic><Genetic Models><Genetic Transcription><Health><High Fat Diet><Hippocampus><Homeostasis><Hypothalamic structure><Hypothalamus><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impaired cognition><In Vitro><Inflammaging><Inflammation><Inflammation Mediators><Inflammatory><Interleukins><Intervention><Ischemia><Knowledge><Learning><Link><MC4 Receptor><Macrophage-Derived TNF><Measures><Mediating><Melanocortin 4 Receptor><Metabolic><Mice><Mice Mammals><Microinjections><Modeling><Molecular><Monocyte-Derived TNF><Movement><Multiple Sclerosis><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuron Degeneration><Neuronal Plasticity><Neurons><Neuropeptides><Obesity><Pathway interactions><Physiological Homeostasis><Population><Predisposition><Primary Senile Degenerative Dementia><Production><QOL><Quality of life><RNA Expression><Receptor Protein><Receptor, Melanocortin, Type 4><Removal><Reporting><Rewards><Rodent><Rodentia><Rodents Mammals><Role><Site><Surgical Removal><Susceptibility><Synapses><Synaptic><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Therapeutic><Transcription><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Viral Vector><Work><a beta peptide><abeta><accelerated aging><accelerated biological age><accelerated biological aging><adiposity><age acceleration><age-related inflammation><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><ages><aging associated inflammation><aging delay><aging population><amyloid beta><amyloid-b protein><astrocytic glia><attenuate aging><beta amyloid fibril><body movement><cardiovascular effects><cell type><central nervous system plasticity><cognitive ability><cognitive assessment><cognitive defects><cognitive dysfunction><cognitive function><cognitive loss><cognitive testing><corpulence><cytokine><decelerate aging><delay age related><design><designing><developmental><driving><elderly mice><enhance healthspan><extend healthspan><extending healthy lifespan><feeding><flow cytophotometry><glial activation><glial cell activation><hallmarks of aging><healthspan extension><hippocampal><hypothalamic><improve healthspan><improved><increase healthspan><inflamm-ageing><inflamm-aging><inflammation associated with aging><inflammatory mediator><insight><insular sclerosis><life span><lifespan><melanocortin receptor><mouse model><multiplex assay><murine model><neural degeneration><neural inflammation><neural plasticity><neurodegeneration><neurodegenerative><neurogenesis><neuroinflammation><neuroinflammatory><neurological degeneration><neuronal><neuronal degeneration><neuroplastic><neuroplasticity><neurotrophic factor><neurotrophin><neutrophin><old mice><pathway><pause aging><pharmacologic><pillars of aging><population aging><postpone age related><prevent><preventing><primary degenerative dementia><prolong healthspan><promote healthspan><promoter><promotor><receptor><receptor expression><resection><response><retards aging><senile dementia of the Alzheimer type><slow aging><slow down aging><slow the rate of aging><social role><soluble amyloid precursor protein><synapse><systemic inflammation><systemic inflammatory response><therapeutic agent development><therapeutic development><therapeutic target>

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Maria Marquine

DUKE UNIVERSITY, DURHAM, NC

Exploratory lead · 30/100

Recent

Active award

Career award

$182,914

FY 2026

Project Title

Research and Mentoring on Neurocognitive Disparities in Aging

Grant Number:

5K24AG075240-05

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/15/2022

End Date:

11/30/2026

Project Abstract

The current K24 Midcareer Investigator Award in Patient-Oriented Research aims to best enable the Principal Investigator, Dr. María Marquine, to advance research on neurocognitive disparities in aging and Alzheimer’s Disease and Related Dementias (ADRDs) among Hispanics/Latinos/as/x (henceforth Hisp...

Research Terms

<19 year old><19 years of age><AD and related dementia><AD dementia><AD detection><AD related dementia><ADRD><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease detection><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's detection><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><American><Area><Award><Awareness><COVID-19 pandemic affected><COVID-19 pandemic consequence><COVID-19 pandemic effects><COVID-19 pandemic impact><COVID-19 pandemic impacted><Capsicum><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Clinical><Cognitive><Cognitive aging><Data><Development><Disparities><Disparity><Early identification><Espanol><Funding><HIV><HIV and aging><HIV associated aging><HIV related aging><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Human Development><Human Immunodeficiency Viruses><IQ Deficit><Infrastructure><International><Intervention><Investigators><K-Awards><K-Series Research Career Programs><K24 Mechanism><K24 Program><LAV-HTLV-III><Latin America><Latina Population><Latina females><Latina women><Latina/e women><Latina/x women><Latinas><Latine females><Latine women><Latino Population><Latino females><Latino group><Latino individual><Latino people><Latino women><Latinos><Latinx females><Latinx women><Leadership><Lymphadenopathy-Associated Virus><Mental Health><Mental Hygiene><Mentors><Midcareer Investigator Award in Patient-Oriented Research><Midcareer Investigator Award in Patient-Oriented Research (K24)><NCMHD><NIH><NIMHD><National Center on Minority Health and Health Disparities><National Institute of Minority Health and Health Disparities><National Institute on Minority Health and Health Disparities><National Institutes of Health><Neurocognitive><Neurocognitive Deficit><Neuropsychologic Tests><Neuropsychological Tests><Neuropsychologies><Neuropsychology><Non-Hispanic><Nonhispanic><North Carolina><Not Hispanic or Latino><Pilot Projects><Population><Position><Positioning Attribute><Primary Senile Degenerative Dementia><Principal Investigator><Process><Psychological Health><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Career Program><Research Grants><Research Infrastructure><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Training><Researchers><Resources><Risk><Risk Factors><Role><Scientist><Spanish><Time><Training><Training Programs><Training and Infrastructure><United States><United States National Institutes of Health><Universities><Virus-HIV><Work><age 19><age 19 years><aging people with HIV><aging population with HIV><aging with HIV><aging with human immunodeficiency virus><career><career development><coronavirus disease 2019 pandemic consequence><coronavirus disease 2019 pandemic impact><dementia risk><developmental><early-career faculty><education research><effects following the COVID-19 pandemic><experience><handheld mobile device><high risk><high school><impact of the SARS-CoV-2 pandemic><improved><intelligence quotient deficit><medical college><medical schools><mobile computing><mobile device><mobile platform><mobile technology><neurocognitive decline><neurocognitive impairment><neuropsychologic><nineteen year old><nineteen years old><patient oriented research><patient oriented study><pepper><pilot study><primary degenerative dementia><programs><protective factors><risk factor for dementia><risk for dementia><school of medicine><senile dementia of the Alzheimer type><skills><social role><stem><tool><tool development>

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Arjumand Ghazi

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 30/100

Recent

Active award

Career award

$120,790

FY 2026

Project Title

A Pipeline for Research, Education and Mentoring in Reproductive Aging

Grant Number:

5K07AG078287-04

Activity Code:

K07

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/15/2023

End Date:

1/31/2028

Project Abstract

A Pipeline for Research, Education and Mentoring in Reproductive Aging Decline in female fertility is one of the earliest age-related deteriorations seen in humans, often decades before signs of somatic aging appear. From a fertility perspective, women are considered geriatric by late 30s and only ~...

Research Terms

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Sarah E Goodale

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Exploratory lead · 30/100

Recent

Active award

Career award

$80,892

FY 2026

Project Title

Longitudinal effects of aging and neurodegeneration on structure-function and brain-behavior relationships

Grant Number:

5K00AG079810-04

Activity Code:

K00

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2022

End Date:

2/28/2029

Project Abstract

PROJECT SUMMARY/ABSTRACT Magnetic resonance imaging (MRI) is a powerful non-invasive tool for imaging brain activity that allows for investigating the dynamically changing activity patterns and structure that give rise to human brain function and dysfunction. Functional MRI (fMRI) signal variations ...

Research Terms

<21+ years old><AD dementia><Address><Adult><Adult Human><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Arousal><Behavioral trial><Benign senescent forgetfulness><Biological Markers><Brain><Brain Nervous System><Brain imaging><Cell Communication and Signaling><Cell Signaling><Clinical><Clinical Markers><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Data><Data Analyses><Data Analysis><Degenerative Neurologic Disorders><Detection><Development><Disease><Disorder><Disturbance in cognition><Drowsiness><Dysfunction><EEG><Electroencephalogram><Electroencephalography><Encephalon><Environment><Faculty><Fatigue><Foundations><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Goals><Human><Image><Imaging Device><Imaging Instrument><Imaging Tool><Impaired cognition><Institution><Interruption><Intracellular Communication and Signaling><Investigators><Knowledge><Laboratories><Lack of Energy><Link><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentorship><Methodology><Methods><Modeling><Modern Man><NMR Imaging><NMR Tomography><Nerve Degeneration><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurosciences><Nuclear Magnetic Resonance Imaging><Pathway interactions><Patients><Pattern><Phase><Physiology><Physiopathology><Play><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Predisposition><Preparation><Primary Senile Degenerative Dementia><Research><Research Associate><Research Personnel><Research Resources><Research Training><Researchers><Resources><Rest><Role><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Somnolence><Source><Statistical Methods><Structure><Susceptibility><System><Training><Universities><Variant><Variation><Vascular Cognitive Impairment><Work><Zeugmatography><aberrant aging><abnormal aging><adult youth><adulthood><age associated><age associated cognitive impairment><age associated disease><age associated disorder><age associated effects><age associated impairment><age associated memory decline><age associated memory deficit><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age effect><age linked><age related><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related effects><age related human disease><age related memory dysfunction><age related neurodegeneration><age specific><age-associated memory impairment><age-driven neurodegenerative disorders><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><age-related disease><age-related disorder><age-related impairment><age-related neurodegenerative disease><age-related neurodegenerative disorder><aging associated><aging associated neurodegeneration><aging associated neurodegenerative disease><aging effect><aging related><aging related cognitive decline><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><alertness><basal forebrain><behavior response><behavioral response><bio-markers><biologic marker><biological signal transduction><biomarker><brain behavior><brain visualization><career><cerebrovascular contribution to cognitive impairment><cerebrovascular contributions to cognitive dysfunction><cholinergic><clinical biomarkers><clinically useful biomarkers><cognitive dysfunction><cognitive loss><common symptom><data interpretation><declining cognitive functions with aging><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><dysfunctional age related change><dysfunctional aging><fMRI><fMRI/EEG><fall asleep><functional magnetic resonance imaging/electroencephalography><healthy aging><healthy human aging><image guidance><image guided><imaging><imaging biomarker><imaging marker><imaging-based biological marker><imaging-based biomarker><imaging-based marker><impact of age><impaired aging><improved><independent component analysis><indexing><influence of age><interest><large data sets><large datasets><maladaptive aging><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><neural degeneration><neural imaging><neuro-imaging><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroimaging><neurological degeneration><neurological imaging><neuronal degeneration><older adult><older adulthood><pathological age related changes><pathological aging><pathophysiology><pathway><patient population><perceptual stimulus><physicochemical phenomena related to the senses><post-doc><post-doctoral><post-doctoral trainee><potential biological marker><potential biomarker><pre-doc><pre-doctoral><preparations><primary degenerative dementia><research associates><senile dementia of the Alzheimer type><sensory stimulus><sleep difficulty><sleep onset><sleepiness><social role><statistic methods><structural imaging><substantia alba><vascular and cognitive impairment><vascular cognition impairment><vascular cognitive decline><vascular cognitive disease><vascular cognitive disorder><vascular cognitive dysfunction><vascular contributions to cognitive decline><vascular contributions to cognitive impairment><vascular disease and impaired cognition><vascular dysfunction resulting in cognitive decline><vascular related cognitive decline><vascular related cognitive impairment><vigilance><white matter><young adult><young adult age><young adulthood>

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Victor Afriyie Ansere

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Exploratory lead · 30/100

Recent

Active award

Career award

$78,734

FY 2026

Project Title

Reversing age-related epigenetic changes and characterizing microglia heterogeneity in obesity and aging

Grant Number:

5K00AG079813-05

Activity Code:

K00

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2022

End Date:

1/31/2028

Project Abstract

Project Summary Neuroinflammation is a hallmark of brain aging that may contribute to declines in function and neurodegenerative diseases. As the resident macrophage of the brain, microglial are crucial to brain maintenance but have been demonstrated to take on pro-inflammatory phenotypes with aging...

Research Terms

<3 year old><3 years of age><Address><Affect><Affinity Chromatography><Age><Aging><Ammon Horn><Animals><Applied Skills><Assay><BODIPY><BS-seq><Bioassay><Bioinformatics><Biological Assay><Biology><Bisulfite-based sequencing><Blood Plasma><Blood Volume><Body Tissues><Brain><Brain Nervous System><Caloric Restriction><Cell Body><Cell Nucleus><Cells><Chemotactic Cytokines><Communication><Cornu Ammonis><DNA><DNA Methylation><DNA Modification><DNA Modification Process><Data><Degenerative Neurologic Disorders><Deoxyribonucleic Acid><Development><Disease><Disorder><Dysfunction><Elements><Encephalon><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epigenetic age><Fats><Fatty acid glycerol esters><Fluorescence Activated Cell Sorting Fractionation><Fluorescence-Activated Cell Sorting><Fluorescence-Activated Cell Sortings><Foundations><Functional disorder><Future><Gene Expression><Genes><Genomics><Goals><Grant><GrimAge clock><Hannum clock><Heterogeneity><High Fat Diet><Hippocampus><Homologous Chemotactic Cytokines><Hortega cell><Horvath clock><Immune Cell Activation><Impairment><Inflammation><Inflammatory><Intercrines><Intervention><Knowledge><Laboratories><Leanness><Lipids><Macrophage><Maintenance><Manuscripts><Mentors><Messenger RNA><Methylation><Mice><Mice Mammals><Microglia><Modeling><Molecular><Morphology><Murine><Mus><Mφ><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Non-Polyadenylated RNA><Nuclear><Nucleus><Nutritional><Obese Mice><Obesity><Operative Procedures><Operative Surgical Procedures><Oral><Pathologic><Pattern><Phagocytes><Phagocytic Cell><Phase><PhenoAge clocks><Phenotype><Physiologic><Physiological><Physiopathology><Plasma><Plasma Serum><Population><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Research><Reticuloendothelial System, Serum, Plasma><Ribonucleic Acid><Ribosomes><Role><SIS cytokines><Saline><Saline Solution><Scientist><Site><Sorting><Structure><Surgical><Surgical Interventions><Surgical Procedure><Technical Expertise><Techniques><Technology><Testing><Thinness><Tissues><Training><Translating><Writing><adiposity><affinity purification><age 3><age 3 years><age associated><age associated alterations><age associated changes><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age group><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age reversal><age specific><age specific alterations><age specific changes><aged brain><aged mice><aged mouse><ages><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging induced epigenetic change><aging prevention><aging preventive intervention><aging related alterations><aging related changes><aging reversal><aging specific alterations><aging specific changes><aging-associated epigenetic change><aging-related epigenetic change><alleviate age related><alleviate aging><alterations with age><amebocyte><ameliorating aging><anti aging><anti geronic><anti-aging intervention><antiaging><bisulfite sequencing><bisulfite-seq><calorie restriction><career><cell type><changes with age><chemoattractant cytokine><chemokine><corpulence><counter age related><counter aging><counteract age related><counteract aging><cytokine><decline in function><decline in functional status><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><diet-associated obesity><diet-induced obesity><diet-related obesity><dietary><elderly mice><entire genome><epigenetic age clocks><epigenetic aging><epigenetic clock><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic molecular clocks><epigenetic regulation of aging><epigenetically><epigenome><epigenome editing><epigenomic editing><epigenomics><experience><full genome><functional decline><functional status decline><gitter cell><hippocampal><immune activation><improved><innovate><innovation><innovative><insight><interest><interventions targeting aging><lab experience><lab training><laboratory experience><laboratory training><late in life><late life><mRNA><mesoglia><methylation clock><microglial cell><microgliocyte><molecular phenotype><mouse model><murine model><neural inflammation><neurodegenerative illness><neuroinflammation><neuroinflammatory><new approaches><novel approaches><novel strategies><novel strategy><nutritious><ob/ob mouse><old mice><pathophysiology><perivascular glial cell><prevent><prevent age related><prevent aging><preventing><rejuvenating intervention><rejuvenation approach><rejuvenation strategies><rejuvenation therapy><rejuvenation treatment><response><reverse age><reverse aging><reverse aging effects><reversible aging><scRNA sequencing><scRNA-seq><sex><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><skills><social role><suppress aging><surgery><systemic inflammation><systemic inflammatory response><technical skills><therapeutic rejuvenation><three year old><three years of age><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translational study><translatome><uptake><whole genome>

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Alden L. Gross

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 30/100

Very recent

Active award

$50,000

FY 2026

Project Title

Conference on Advanced Psychometric Methods in Cognitive Aging Research

Grant Number:

5R13AG085953-03

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The rising prevalence with advancing age and the adverse impact of debilitating diseases like Alzheimer’s disease and related dementias (ADRD) has led to a need for clinical and research methods for measurement of effects of these diseases. Cognitive tests, biomarkers, informant reports, imaging dat...

Research Terms

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Kyle J. Bourassa

DURHAM VA MEDICAL CENTER, DURHAM, NC

Exploratory lead · 30/100

Very recent

Active award

$0

FY 2026

Project Title

Posttraumatic Stress Disorder, Accelerated Biological Aging, and Veteran Health

Grant Number:

5IK2CX002694-03

Activity Code:

IK2

Mechanism:

Other

Agency:

VA

Start Date:

7/1/2023

End Date:

6/30/2028

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Posttraumatic stress disorder (PTSD) is a prevalent and costly mental health disorder associated with poorer health and higher healthcare utilization. These outcomes are a particular concern among Veterans, who have higher rates of PTSD compared to civilian populations. Veterans with PTSD, for examp...

Research Terms

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ERIKA J WOLF

VA BOSTON HEALTH CARE SYSTEM, BOSTON, MA

Exploratory lead · 30/100

Very recent

Active award

$0

FY 2026

Project Title

Traumatic Stress, Epigenetic Aging, and Cardiovascular Risk in the Million Veteran Program

Grant Number:

1I01BX006510-01A1

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

4/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Background & Innovation: This project will make use of Million Veteran Program (MVP) data to address questions concerning the relationships between traumatic stress, epigenetic aging in DNA methylation data, and cardiovascular disease (CVD, including ischemic stroke, myocardial infarction, coronary ...

Research Terms

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AUDREY L JONES

VA SALT LAKE CITY HEALTHCARE SYSTEM, SALT LAKE CITY, UT

Exploratory lead · 30/100

Very recent

Active award

$0

FY 2026

Project Title

Enhancing Services in Project-Based SupportiveHousing for Aging Homeless-Experienced Veterans

Grant Number:

1I01RD000651-01A2

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

4/1/2026

End Date:

3/31/2030

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Significance: Older Veterans who experience homelessness (VEH) often have chronic disease burdens and functional impairments that far exceed their chronological age, persist after housing is obtained, and contribute to frequent hospitalizations and early admission into long-term care facilities. Mos...

Research Terms

<21+ years old><Activities of Daily Living><Activities of everyday life><Address><Admission><Admission activity><Adult><Adult Human><Age><Aging><Caring><Case Management><Characteristics><Chronology><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Competence><Consensus><Country><Data><Debility><Decision Making><Dedications><Development><Diminished Vision><Discipline of Nursing><Disturbance in cognition><ED visit><ER visit><Effectiveness><Elderly><Elements><Emergencies><Emergency Situation><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><Friends><Functional impairment><Funding><Goals><Health><Health Care><Health Care Costs><Health Care Facility><Health Care Systems><Health Care Utilization><Health Costs><Health Facilities><Health system><Hearing Loss><History><Home><Home Care><Homeless persons><Homelessness><Hospital Admission><Hospitalization><Hospitals><Housing><Housing and Urban Development><Hypoacuses><Hypoacusis><Impaired cognition><Inpatients><Interview><Investments><Learning><Letters><Long-Term Care><Low Vision><Measures><Medical center><Methodology><Modeling><Natural experiment><Nursing><Nursing Field><Nursing Homes><Nursing Profession><Occupational Therapy><Older Population><Out-patients><Outcome><Outpatients><PRISM framework><PRISM model><Partial Sight><Perception><Population><Practical Robust Implementation and Sustainability Model><Pragmatic, Robust Implementation and Sustainability Model><Process><Program Evaluation><Provider><Quantitative Evaluations><RE-AIM><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Recording of previous events><Reduced Vision><Research><Research Priority><Research Resources><Resources><Sampling><San Francisco><Science Policy><Service delivery model><Service model><Services><Site><Social Service><Social Work><Strategic Planning><Structure><Subnormal Vision><Suggestion><Survey Instrument><Surveys><Testing><Time><Translations><U.S. Department of Housing and Urban Development><United States Department of Veterans Affairs><United States Veterans Administration><Variant><Variation><Veterans><Veterans Administration><Veterans Affairs><Visual impairment><Work><adulthood><advanced age><age associated><age correlated><age dependent><age linked><age related><age specific><aged><ages><aging associated><aging related><assessing cost effectiveness><burden of chronic disease><burden of chronic illness><care delivery model><care facilities><cognitive dysfunction><cognitive loss><compare cost><cost><cost comparison><cost-effectiveness evaluation><daily living function><daily living functionality><determine cost effectiveness><developmental><disability burden><dysfunctional hearing><effectiveness testing><evaluate cost-effectiveness><evidence base><examine cost effectiveness><experience><extended care><facilitators to implementation><falls><functional ability><functional capacity><geriatric><health care delivery model><health care service use><health care service utilization><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><histories><homeless><homeless group><homeless individual><homeless population><homes><houselessness><implementation facilitators><implementation strategy><improved><innovate><innovation><innovative><meeting><meetings><multidisciplinary><nursing home><older adult><older adulthood><older groups><older individuals><older person><patient home care><patient homecare><premature><prematurity><prevent><preventing><pro-aging><progeronic><programs><promote aging><reach, efficacy, adoption, implementation, and maintenance><satisfaction><senior citizen><service delivery><service programs><service providers><social health determinants><strategies for implementation><supported housing><supportive housing><tool><translation><unhoused><uptake><vision impairment><visually impaired>

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JACK TSAI

VA SALT LAKE CITY HEALTHCARE SYSTEM, SALT LAKE CITY, UT

Exploratory lead · 30/100

Very recent

Active award

$0

FY 2026

Project Title

Enhancing Services in Project-Based SupportiveHousing for Aging Homeless-Experienced Veterans

Grant Number:

1I01RD000651-01A2

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

4/1/2026

End Date:

3/31/2030

Why this may be worth a closer look

• Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Significance: Older Veterans who experience homelessness (VEH) often have chronic disease burdens and functional impairments that far exceed their chronological age, persist after housing is obtained, and contribute to frequent hospitalizations and early admission into long-term care facilities. Mos...

Research Terms

<21+ years old><Activities of Daily Living><Activities of everyday life><Address><Admission><Admission activity><Adult><Adult Human><Age><Aging><Caring><Case Management><Characteristics><Chronology><Clinical><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Competence><Consensus><Country><Data><Debility><Decision Making><Dedications><Development><Diminished Vision><Discipline of Nursing><Disturbance in cognition><ED visit><ER visit><Effectiveness><Elderly><Elements><Emergencies><Emergency Situation><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><Friends><Functional impairment><Funding><Goals><Health><Health Care><Health Care Costs><Health Care Facility><Health Care Systems><Health Care Utilization><Health Costs><Health Facilities><Health system><Hearing Loss><History><Home><Home Care><Homeless persons><Homelessness><Hospital Admission><Hospitalization><Hospitals><Housing><Housing and Urban Development><Hypoacuses><Hypoacusis><Impaired cognition><Inpatients><Interview><Investments><Learning><Letters><Long-Term Care><Low Vision><Measures><Medical center><Methodology><Modeling><Natural experiment><Nursing><Nursing Field><Nursing Homes><Nursing Profession><Occupational Therapy><Older Population><Out-patients><Outcome><Outpatients><PRISM framework><PRISM model><Partial Sight><Perception><Population><Practical Robust Implementation and Sustainability Model><Pragmatic, Robust Implementation and Sustainability Model><Process><Program Evaluation><Provider><Quantitative Evaluations><RE-AIM><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Recording of previous events><Reduced Vision><Research><Research Priority><Research Resources><Resources><Sampling><San Francisco><Science Policy><Service delivery model><Service model><Services><Site><Social Service><Social Work><Strategic Planning><Structure><Subnormal Vision><Suggestion><Survey Instrument><Surveys><Testing><Time><Translations><U.S. Department of Housing and Urban Development><United States Department of Veterans Affairs><United States Veterans Administration><Variant><Variation><Veterans><Veterans Administration><Veterans Affairs><Visual impairment><Work><adulthood><advanced age><age associated><age correlated><age dependent><age linked><age related><age specific><aged><ages><aging associated><aging related><assessing cost effectiveness><burden of chronic disease><burden of chronic illness><care delivery model><care facilities><cognitive dysfunction><cognitive loss><compare cost><cost><cost comparison><cost-effectiveness evaluation><daily living function><daily living functionality><determine cost effectiveness><developmental><disability burden><dysfunctional hearing><effectiveness testing><evaluate cost-effectiveness><evidence base><examine cost effectiveness><experience><extended care><facilitators to implementation><falls><functional ability><functional capacity><geriatric><health care delivery model><health care service use><health care service utilization><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><histories><homeless><homeless group><homeless individual><homeless population><homes><houselessness><implementation facilitators><implementation strategy><improved><innovate><innovation><innovative><meeting><meetings><multidisciplinary><nursing home><older adult><older adulthood><older groups><older individuals><older person><patient home care><patient homecare><premature><prematurity><prevent><preventing><pro-aging><progeronic><programs><promote aging><reach, efficacy, adoption, implementation, and maintenance><satisfaction><senior citizen><service delivery><service programs><service providers><social health determinants><strategies for implementation><supported housing><supportive housing><tool><translation><unhoused><uptake><vision impairment><visually impaired>

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David J Clark

VETERANS HEALTH ADMINISTRATION, GAINESVILLE, FL

Exploratory lead · 30/100

Recent

Active award

Team-scale grant

$0

FY 2026

Project Title

Aging with a Traumatic Brain Injury: Implications for Balance Deficits and Fall Risk

Grant Number:

5I21RX004641-03

Activity Code:

I21

Mechanism:

Research Centers

Agency:

VA

Start Date:

7/1/2023

End Date:

6/30/2026

Project Abstract

Accumulating research indicates that a TBI sustained in early or middle adulthood has the potential to influence the trajectory of the aging process, both in the context of brain function and whole-body health. People who consider themselves to be fully recovered and asymptomatic many years followin...

Research Terms

<21+ years old><Acceleration><Acquired brain injury><Acute><Adult><Adult Human><Age><Aging><Area><Bone Density><Bone Mineral Density><Brain><Brain Injuries><Brain Nervous System><Brain Trauma><Chronic><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Complex><Control Groups><Craniocerebral Injuries><Craniocerebral Trauma><Data Set><Disturbance in cognition><Eligibility><Eligibility Determination><Encephalon><Enrollment><Equilibrium><Exhibits><Future><Goals><Gulf War><Head Injuries><Head Trauma><Health><History><Impaired cognition><Individual><Injury><Intervention><Investigation><Knowledge><Learning><Life Style Modification><Literature><Measures><Medical Rehabilitation><Motor><Neuroendocrine><Neuroendocrine System><Neurosecretory Systems><Operation Desert Shield><Operation Desert Storm><Participant><Pathway interactions><Patient Self-Report><Performance><Persons><Physical Function><Population><Predisposition><Process><Protocol Screening><Recording of previous events><Regression Analyses><Regression Analysis><Regression Diagnostics><Rehabilitation><Rehabilitation therapy><Reporting><Research><Risk><Risk Factors><Self-Report><Severities><Societies><Statistical Regression><Susceptibility><TBI recovery><Testing><Traumatic Brain Injury><Traumatic Brain Injury recovery><Uncertainty><Veterans><Visuospatial><adulthood><age associated effects><age associated neurodegeneration><age associated neurodegenerative disease><age associated neurodegenerative disorder><age dependent neurodegeneration><age dependent neurodegenerative condition><age dependent neurodegenerative disease><age dependent neurodegenerative disorder><age effect><age group><age related effects><age related neurodegeneration><age-driven neurodegenerative disorders><age-related neurodegenerative disease><age-related neurodegenerative disorder><ages><aging associated neurodegeneration><aging associated neurodegenerative disease><aging effect><aging process><aging related neurodegeneration><aging related neurodegenerative disease><aging related neurodegenerative disorder><balance><balance disorder><balance function><balance impairment><balance testing><brain damage><brain health><brain-injured><co-morbid><co-morbidity><cognitive assessment><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive testing><cohort><comorbidity><cost><design><designing><disability><disturbed balance><doubt><enroll><equilibration disorder><equilibrium disorder><experience><eye tracking><fall risk><falls><healthspan extending intervention><healthspan extending therapies><healthspan intervention><healthspan promoting intervention><healthspan promoting therapies><healthspan therapies><healthy aging intervention><histories><impact of age><improved><influence of age><injuries><intervention to promote healthy aging><interventions to improve healthspan><life span><life style intervention><lifespan><lifestyle intervention><lifestyle modification><motor deficit><motor impairment><movement impairment><movement limitation><neural control><neural inflammation><neural regulation><neuroinflammation><neuroinflammatory><neuromodulation><neuromodulatory><neuroregulation><ocular motor><ocularmotor><oculomotor><old age><pathway><peer><preservation><pressure><recovery after TBI><recovery after traumatic brain injury><rehab therapy><rehabilitative><rehabilitative therapy><secondary outcome><traumatic brain damage><visual spatial><visual tracking>

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Michael J Sheehan

CORNELL UNIVERSITY, ITHACA, NY

Exploratory lead · 26/100

Solid budget

Active award

$458,871

FY 2026

Project Title

Epigenetic Aging: The Impact of Social and Environmental Realism

Grant Number:

1R21AG093628-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

Correlational studies in human populations strongly indicate that the environment in which we live has a large impact on our health and well-being, including influencing lifespan and relative rates of aging. Increasingly, it is clear that both the physical and social environments in which we are emb...

Research Terms

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Wanding Zhou

CORNELL UNIVERSITY, ITHACA, NY

Exploratory lead · 26/100

Solid budget

Active award

$458,871

FY 2026

Project Title

Epigenetic Aging: The Impact of Social and Environmental Realism

Grant Number:

1R21AG093628-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

Correlational studies in human populations strongly indicate that the environment in which we live has a large impact on our health and well-being, including influencing lifespan and relative rates of aging. Increasingly, it is clear that both the physical and social environments in which we are emb...

Research Terms

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Eleonora Scorletti

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 26/100

Solid budget

Active award

$446,875

FY 2026

Project Title

Investigating the Role of Genetic Variants and Aging on Eicosanoid Metabolism in Adipose Tissue

Grant Number:

1R21AG093405-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2026

End Date:

12/31/2028

Project Abstract

1 Background. This research project leverages humans as a model system to investigate how 2 specific genetic variants and aging jointly influence polyunsaturated fatty acid (PUFA) 3 metabolism in white adipose tissue (WAT). WAT plays a crucial role in maintaining energy 4 homeostasis, serving both...

Research Terms

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Shawn Brady Bender

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Exploratory lead · 26/100

Solid budget

Active award

$429,394

FY 2026

Project Title

Targeting LARP6 in aging-associated heart failure

Grant Number:

1R21AG095557-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2025

End Date:

11/30/2027

Project Abstract

Aging with co-morbid conditions (i.e., obesity, hypertension) increases the risk of developing heart failure with preserved ejection fraction (HFpEF), and related cardiovascular morbidity and mortality for which there are few approved treatments. Importantly, HFpEF has become the most common form of...

Research Terms

<21+ years old><5' Untranslated Regions><5'UTR><Adrenergic Agents><Adrenergic Drugs><Adrenergics><Adult><Adult Human><Adverse Experience><Adverse event><Age Years><Aging><AngII><Angiogenesis Factor><Angiogenic Factor><Angiotensin II><Atomic Force Microscopy><Attenuated><Binding><Blood Vessels><Blood capillaries><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Communication and Signaling><Cell Signaling><Cell-Extracellular Matrix><Chronic><Collagen><Collagen Type I><Coupled><DNA mutation><Data><Deposit><Deposition><Development><Diastolic heart failure><Dysfunction><ECM><Elderly><Exhibits><Extracellular Matrix><Fats><Fatty acid glycerol esters><Fibrillar Collagen><Fibrosis><Fibrosis in the heart><Fibrosis in the myocardium><Fibrosis within the heart><Fibrosis within the myocardium><Fibrotic myocardium><Force Microscopy><Functional disorder><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><HF with preserved ejection fraction><HFpEF><Heart><Heart Diseases><Heart Muscle Cells><Heart Vascular><Heart failure><Heart myocyte><Hypertension><Infusion><Infusion procedures><Intervention><Intracellular Communication and Signaling><KI mice><Knock-in Mouse><Leanness><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Mediator><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Messenger RNA><Mice><Mice Mammals><Modeling><Molecular><Molecular Analysis><Molecular Interaction><Morbidity><Morphology><Murine><Mus><Muscle Cells><Mutant Strains Mice><Mutate><Mutation><Myocardial depression><Myocardial dysfunction><Myocytes><NMR Imaging><NMR Tomography><Nuclear Magnetic Resonance Imaging><Obesity><Pathologic><Physiopathology><Play><Population><Post-Transcriptional Control><Post-Transcriptional Regulation><Production><RNA-Binding Proteins><Research><Ribonucleoproteins><Risk><Risk Factors><Role><Scanning Force Microscopy><Signal Transduction><Signal Transduction Systems><Signaling><Staining method><Stains><Stress><Structure><Testing><Therapeutic><Thinness><Translations><Type 1 Collagen><VEGF><VEGFs><Vascular Endothelial Growth Factors><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Vasculogenic><Ventricular><Zeugmatography><adiposity><adulthood><advanced age><aged><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><aging associated><aging population><aging related><attenuate><attenuates><biological signal transduction><capillary><cardiac dysfunction><cardiac failure><cardiac fibrosis><cardiac function><cardiomyocyte><cardiovascular risk><cardiovascular risk factor><circulatory system><co-morbid><co-morbidity><comorbidity><coronary fibrosis><corpulence><density><developmental><druggable target><elderly mice><feeding><fibrotic heart><function of the heart><gene signatures><genetic signature><genome mutation><geriatric><global gene expression><global transcription profile><heart disorder><heart dysfunction><heart failure with preserved ejection fraction><heart failure with preserved systolic function><heart fibrosis><heart function><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><improved outcome><in vivo><infusions><innovate><innovation><innovative><interstitial><knockin mice><mRNA><mRNA Leader Sequences><mRNA Stability><mortality><mouse model><mouse mutant><murine model><myocardial fibrosis><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><old mice><pathophysiology><patient population><pharmacologic><population aging><post-transcriptional gene regulation><preserved ejection fraction heart failure><prevent><preventing><response><senior citizen><social role><stem><therapeutic target><tissue culture><transcriptome><translation><treatment strategy><vascular>

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Chandrasekar Bysani

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Exploratory lead · 26/100

Solid budget

Active award

$429,394

FY 2026

Project Title

Targeting LARP6 in aging-associated heart failure

Grant Number:

1R21AG095557-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2025

End Date:

11/30/2027

Project Abstract

Aging with co-morbid conditions (i.e., obesity, hypertension) increases the risk of developing heart failure with preserved ejection fraction (HFpEF), and related cardiovascular morbidity and mortality for which there are few approved treatments. Importantly, HFpEF has become the most common form of...

Research Terms

<21+ years old><5' Untranslated Regions><5'UTR><Adrenergic Agents><Adrenergic Drugs><Adrenergics><Adult><Adult Human><Adverse Experience><Adverse event><Age Years><Aging><AngII><Angiogenesis Factor><Angiogenic Factor><Angiotensin II><Atomic Force Microscopy><Attenuated><Binding><Blood Vessels><Blood capillaries><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Cell Communication and Signaling><Cell Signaling><Cell-Extracellular Matrix><Chronic><Collagen><Collagen Type I><Coupled><DNA mutation><Data><Deposit><Deposition><Development><Diastolic heart failure><Dysfunction><ECM><Elderly><Exhibits><Extracellular Matrix><Fats><Fatty acid glycerol esters><Fibrillar Collagen><Fibrosis><Fibrosis in the heart><Fibrosis in the myocardium><Fibrosis within the heart><Fibrosis within the myocardium><Fibrotic myocardium><Force Microscopy><Functional disorder><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><HF with preserved ejection fraction><HFpEF><Heart><Heart Diseases><Heart Muscle Cells><Heart Vascular><Heart failure><Heart myocyte><Hypertension><Infusion><Infusion procedures><Intervention><Intracellular Communication and Signaling><KI mice><Knock-in Mouse><Leanness><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Mediator><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Messenger RNA><Mice><Mice Mammals><Modeling><Molecular><Molecular Analysis><Molecular Interaction><Morbidity><Morphology><Murine><Mus><Muscle Cells><Mutant Strains Mice><Mutate><Mutation><Myocardial depression><Myocardial dysfunction><Myocytes><NMR Imaging><NMR Tomography><Nuclear Magnetic Resonance Imaging><Obesity><Pathologic><Physiopathology><Play><Population><Post-Transcriptional Control><Post-Transcriptional Regulation><Production><RNA-Binding Proteins><Research><Ribonucleoproteins><Risk><Risk Factors><Role><Scanning Force Microscopy><Signal Transduction><Signal Transduction Systems><Signaling><Staining method><Stains><Stress><Structure><Testing><Therapeutic><Thinness><Translations><Type 1 Collagen><VEGF><VEGFs><Vascular Endothelial Growth Factors><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Vasculogenic><Ventricular><Zeugmatography><adiposity><adulthood><advanced age><aged><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><aging associated><aging population><aging related><attenuate><attenuates><biological signal transduction><capillary><cardiac dysfunction><cardiac failure><cardiac fibrosis><cardiac function><cardiomyocyte><cardiovascular risk><cardiovascular risk factor><circulatory system><co-morbid><co-morbidity><comorbidity><coronary fibrosis><corpulence><density><developmental><druggable target><elderly mice><feeding><fibrotic heart><function of the heart><gene signatures><genetic signature><genome mutation><geriatric><global gene expression><global transcription profile><heart disorder><heart dysfunction><heart failure with preserved ejection fraction><heart failure with preserved systolic function><heart fibrosis><heart function><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><improved outcome><in vivo><infusions><innovate><innovation><innovative><interstitial><knockin mice><mRNA><mRNA Leader Sequences><mRNA Stability><mortality><mouse model><mouse mutant><murine model><myocardial fibrosis><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><old mice><pathophysiology><patient population><pharmacologic><population aging><post-transcriptional gene regulation><preserved ejection fraction heart failure><prevent><preventing><response><senior citizen><social role><stem><therapeutic target><tissue culture><transcriptome><translation><treatment strategy><vascular>

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Hang Lin

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 26/100

Solid budget

Active award

$428,123

FY 2026

Project Title

Suppressing aging-associated increase of GATA4 levels to rejuvenate old chondrocytes

Grant Number:

1R21AG097876-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

Abstract: The exposure of articular cartilage to excessive forces, combined with its limited ability to self-repair, can lead to chondral defects. If left untreated, these defects may initiate pathological changes in other joint components, ultimately resulting in osteoarthritis (OA). Importantly, t...

Research Terms

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JEFFREY H ALBRECHT

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 26/100

Solid budget

Active award

$423,500

FY 2026

Project Title

Exploring the links between cyclin D1, metabolism and aging

Grant Number:

1R21AG093623-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Aging is a fundamental driver of many chronic conditions, including obesity, type II diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as fatty liver disease). Numerous aging-related pathologies are promoted by overnutrition and are associa...

Research Terms

<21+ years old><Address><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><Age><Age related pathologies><Aging><Animals><Autophagocytosis><Autoregulation><Auxins><Biologic Models><Biological><Biological Function><Biological Models><Biological Process><Body Tissues><C elegans><C. elegans><C.elegans><CCND1 Protein><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Caenorhabditis elegans><Cancers><Cardiovascular Diseases><Cas nuclease technology><Catabolic Process><Catabolism><Cell Communication and Signaling><Cell Cycle><Cell Cycle Progression><Cell Cycle Proteins><Cell Division Cycle><Cell Division Cycle Proteins><Cell Signaling><Cell-Cycle Regulatory Proteins><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cyclin D1><Cyclin-Dependent Kinases><Cyclin-Dependent Protein Kinases><D-Glucose><Data><Dextrose><Elderly><Engineering><Event><Fatty Acids><Foundations><Future><G1/S-Specific Cyclin D1><Genes><Genetic><Genetic Models><Glucose><Health><Health Care><Hepatic><Hepatic Cells><Hepatic Disorder><Hepatic Parenchymal Cell><Hepatocyte><Homeostasis><Human><Increase lifespan><Intermediary Metabolism><Intestinal><Intestines><Intracellular Communication and Signaling><Ketosis-Resistant Diabetes Mellitus><Length><Link><Lipase><Lipids><Lipolysis><Liver><Liver Cells><Liver diseases><Malignant Neoplasms><Malignant Tumor><Maturity-Onset Diabetes Mellitus><Measures><Mediating><Mediator><Metabolic><Metabolic Control><Metabolic Pathway><Metabolic Processes><Metabolic dysfunction><Metabolic syndrome><Metabolism><Mice><Mice Mammals><Model System><Modeling><Modern Man><Murine><Mus><NIDDM><Nematoda><Nematodes><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nuclear Hormone Receptor Superfamily><Nuclear Hormone Receptors><Nutrient><Nutrition><Nutritional status><Obesity><Obesity Epidemic><Ortholog><Orthologous Gene><Outcome><Overnutrition><PRAD1 Protein><Pathway interactions><Physiological Homeostasis><Play><Post-Transcriptional Gene Silencing><Proliferating><Proteins><Proto-Oncogene Proteins c-bcl-1><RNA Interference><RNA Seq><RNA Silencing><RNA sequencing><RNAi><RNAseq><Repression><Role><Sequence-Specific Posttranscriptional Gene Silencing><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><System><T2 DM><T2D><T2DM><Testing><Therapeutic><Tissues><Triacylglycerol Hydrolase><Triacylglycerol Lipase><Triacylglycerol acylhydrolase><Tributyrinase><Triglyceridase><Triglyceride Lipase><Triolean Hydrolase><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Visualization><Work><adiposity><adult onset diabetes><adulthood><advanced age><age associated><age associated pathologies><age correlated><age dependent><age dependent pathologies><age induced pathologies><age linked><age related><age specific><ages><aging associated><aging associated pathologies><aging dependent pathologies><aging induced pathologies><aging nutrition><aging pathologies><aging related><aging related pathologies><autophagy><bcl-1 Proto-Oncogene Products><bcl-1 Proto-Oncogene Proteins><bcl1 Proto-Oncogene Proteins><biologic><biological signal transduction><boost longevity><bowel><c-bcl-1 Proteins><cardiovascular disorder><cartilage link protein><cdc Proteins><cdk Proteins><combat><corpulence><cyclin D><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><fat metabolism><fatty acid oxidation><fatty liver disease><feeding><foster longevity><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><genome editing><genomic editing><geriatric><hatching><healthspan><healthy life span><hepatic body system><hepatic disease><hepatic organ system><hepatopathy><improve lifespan><improve longevity><ketosis resistant diabetes><knock-down><knockdown><life span><lifespan><lifespan extension><link protein><lipid metabolism><liver disorder><malignancy><maturity onset diabetes><mutant><neoplasm/cancer><novel><overexpress><overexpression><oxidation><pathway><peroxisome><pro-aging><progeronic><prolong lifespan><prolong longevity><promote aging><promote lifespan><promote longevity><response><roundworm><senior citizen><social role><spatial and temporal><spatial temporal><spatiotemporal><support longevity><therapeutic evaluation><therapeutic testing><tool><transcriptome sequencing><transcriptomic sequencing><tributyrase><type 2 DM><type II DM><type two diabetes>

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MATTHEW SIMON GILL

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 26/100

Solid budget

Active award

$423,500

FY 2026

Project Title

Exploring the links between cyclin D1, metabolism and aging

Grant Number:

1R21AG093623-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Aging is a fundamental driver of many chronic conditions, including obesity, type II diabetes and metabolic dysfunction-associated steatotic liver disease (MASLD, formerly known as fatty liver disease). Numerous aging-related pathologies are promoted by overnutrition and are associa...

Research Terms

<21+ years old><Address><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><Age><Age related pathologies><Aging><Animals><Autophagocytosis><Autoregulation><Auxins><Biologic Models><Biological><Biological Function><Biological Models><Biological Process><Body Tissues><C elegans><C. elegans><C.elegans><CCND1 Protein><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Caenorhabditis elegans><Cancers><Cardiovascular Diseases><Cas nuclease technology><Catabolic Process><Catabolism><Cell Communication and Signaling><Cell Cycle><Cell Cycle Progression><Cell Cycle Proteins><Cell Division Cycle><Cell Division Cycle Proteins><Cell Signaling><Cell-Cycle Regulatory Proteins><Chronic><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cyclin D1><Cyclin-Dependent Kinases><Cyclin-Dependent Protein Kinases><D-Glucose><Data><Dextrose><Elderly><Engineering><Event><Fatty Acids><Foundations><Future><G1/S-Specific Cyclin D1><Genes><Genetic><Genetic Models><Glucose><Health><Health Care><Hepatic><Hepatic Cells><Hepatic Disorder><Hepatic Parenchymal Cell><Hepatocyte><Homeostasis><Human><Increase lifespan><Intermediary Metabolism><Intestinal><Intestines><Intracellular Communication and Signaling><Ketosis-Resistant Diabetes Mellitus><Length><Link><Lipase><Lipids><Lipolysis><Liver><Liver Cells><Liver diseases><Malignant Neoplasms><Malignant Tumor><Maturity-Onset Diabetes Mellitus><Measures><Mediating><Mediator><Metabolic><Metabolic Control><Metabolic Pathway><Metabolic Processes><Metabolic dysfunction><Metabolic syndrome><Metabolism><Mice><Mice Mammals><Model System><Modeling><Modern Man><Murine><Mus><NIDDM><Nematoda><Nematodes><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nuclear Hormone Receptor Superfamily><Nuclear Hormone Receptors><Nutrient><Nutrition><Nutritional status><Obesity><Obesity Epidemic><Ortholog><Orthologous Gene><Outcome><Overnutrition><PRAD1 Protein><Pathway interactions><Physiological Homeostasis><Play><Post-Transcriptional Gene Silencing><Proliferating><Proteins><Proto-Oncogene Proteins c-bcl-1><RNA Interference><RNA Seq><RNA Silencing><RNA sequencing><RNAi><RNAseq><Repression><Role><Sequence-Specific Posttranscriptional Gene Silencing><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><System><T2 DM><T2D><T2DM><Testing><Therapeutic><Tissues><Triacylglycerol Hydrolase><Triacylglycerol Lipase><Triacylglycerol acylhydrolase><Tributyrinase><Triglyceridase><Triglyceride Lipase><Triolean Hydrolase><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Visualization><Work><adiposity><adult onset diabetes><adulthood><advanced age><age associated><age associated pathologies><age correlated><age dependent><age dependent pathologies><age induced pathologies><age linked><age related><age specific><ages><aging associated><aging associated pathologies><aging dependent pathologies><aging induced pathologies><aging nutrition><aging pathologies><aging related><aging related pathologies><autophagy><bcl-1 Proto-Oncogene Products><bcl-1 Proto-Oncogene Proteins><bcl1 Proto-Oncogene Proteins><biologic><biological signal transduction><boost longevity><bowel><c-bcl-1 Proteins><cardiovascular disorder><cartilage link protein><cdc Proteins><cdk Proteins><combat><corpulence><cyclin D><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><fat metabolism><fatty acid oxidation><fatty liver disease><feeding><foster longevity><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><genome editing><genomic editing><geriatric><hatching><healthspan><healthy life span><hepatic body system><hepatic disease><hepatic organ system><hepatopathy><improve lifespan><improve longevity><ketosis resistant diabetes><knock-down><knockdown><life span><lifespan><lifespan extension><link protein><lipid metabolism><liver disorder><malignancy><maturity onset diabetes><mutant><neoplasm/cancer><novel><overexpress><overexpression><oxidation><pathway><peroxisome><pro-aging><progeronic><prolong lifespan><prolong longevity><promote aging><promote lifespan><promote longevity><response><roundworm><senior citizen><social role><spatial and temporal><spatial temporal><spatiotemporal><support longevity><therapeutic evaluation><therapeutic testing><tool><transcriptome sequencing><transcriptomic sequencing><tributyrase><type 2 DM><type II DM><type two diabetes>

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Shakira Franco Suglia

EMORY UNIVERSITY, ATLANTA, GA

Exploratory lead · 26/100

Solid budget

Active award

$391,250

FY 2026

Project Title

Reproductive events, menopause and biological aging among Latina women

Grant Number:

1R56AG097727-01

Activity Code:

R56

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2027

Project Abstract

Project Summary The impact of reproductive events on menopause and aging processes is largely unknown. While menopause is part of the aging process, the timing of menopause varies with earlier onset associated with risk of premature mortality. Latina women’s timing and frequency of reproductive even...

Research Terms

<21+ years old><Abdominal Delivery><Acceleration><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><Age><Aging><Amentia><Application Context><Assay><Bioassay><Biological Aging><Biological Assay><Birth><Blood Sample><Blood specimen><C section><Cannot achieve a pregnancy><Cardiac Diseases><Cardiac Disorders><Cardiovascular Diseases><Caucasian Females><Caucasian Women><Central America><Cesarean><Cesarean section><Chicago><Chronic Disease><Chronic Illness><Cities><Communities><Country><DNA Alteration><DNA Methylation><DNA Sequence Alteration><Dementia><Difficulty conceiving><Disease><Disorder><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epigenetic age><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Event><Frequencies><Gender><Genes><Genetic Alteration><Gestation><Gestational Diabetes><Gestational Diabetes Mellitus><Gestational Hypertension><Gynecologic><HCHS/SOL Study><HCHS/SOL cohort><HPA axis><Health><Heart Diseases><High Risk Woman><Hispanic><Hispanic Community Health Study/Study of Latinos><Hypertension induced by pregnancy><Individual><Infertility><Inflammatory><Infrastructure><Intervention><Ketosis-Resistant Diabetes Mellitus><Latina><Latina Population><Latina females><Latina women><Latina/e women><Latina/x women><Latinas><Latine females><Latine women><Latino><Latino Population><Latino females><Latino group><Latino individual><Latino people><Latino women><Latinos><Latinx females><Latinx women><Longitudinal Studies><Longitudinal Surveys><Maturity-Onset Diabetes Mellitus><Menarche><Menopausal Status><Menopausal Symptom><Menopause><Mexico><Molecular><NIDDM><Non-Hispanic><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Nonhispanic><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Not Hispanic or Latino><Osteoporosis><Parturition><Pathway interactions><Perimenopausal><Perimenopause><Persons><Phone><Polycystic Ovarian Disease><Polycystic Ovarian Syndrome><Polycystic Ovary Syndrome><Population><Post-Menopause><Post-menopausal Period><Postmenopausal Period><Postmenopause><Pre-Menopause><Pre-menopausal Period><Pregnancy><Pregnancy Associated Hypertension><Pregnancy Complications><Pregnancy-Induced Diabetes><Premature Birth><Premature Menopause><Premature Mortality><Prematurely delivering><Premenopausal><Premenopausal Period><Premenopause><Preterm Birth><Puberty><Racial Group><Research><Research Resources><Resources><Risk><Sampling><Sclerocystic Ovarian Degeneration><Sclerocystic Ovary Syndrome><Sequence Alteration><Severities><Slow-Onset Diabetes Mellitus><Social Environment><Socioeconomically disadvantaged><Stable Diabetes Mellitus><Symptoms><System><T2 DM><T2D><T2DM><Telephone><Time><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><White Females><White Women><Woman><accelerated aging><accelerated biological age><accelerated biological aging><adult onset diabetes><adulthood><adverse birth outcomes><after menopause><age acceleration><ages><aging biological marker><aging biomarker><aging induced epigenetic change><aging marker><aging process><aging-associated epigenetic change><aging-related epigenetic change><at-risk females><at-risk women><biological age><biological process of age><black female><black women><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><childbearing age><chronic disorder><clinical practice><cohort><complications during pregnancy><contextual factors><deprivation><design><designing><early experience><early menopause><early onset><epigenetic aging><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic regulation of aging><epigenetically><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><ethnic subgroup><ethnicity group><experience><females at high risk><fertile age><fertility cessation><fertility loss><following menopause><genome wide methylation><genomewide methylation><genomic alteration><global methylation><healing><heart disorder><high risk females><hypertension during pregnancy><hypertension in pregnancy><hypertensive pregnancy><hypothalamic-pituitary-adrenal (HPA) axis><hypothalamic-pituitary-adrenal axis><hypothalmus-pituitary-adrenal axis><infertile><ketosis resistant diabetes><later in life><later life><long-term study><longitudinal outcome studies><longitudinal research study><maternal outcome><maturity onset diabetes><menopausal aging><menopause transition><mortality><mother outcome><parity><past menopause><pathway><peri-menopausal><peri-menopause><polycystic ovary><polycystic ovary disease><polycystic ovary disorder><post-menopausal><postmenopausal><postmenopausal status><pre-menopausal><pregnancy characterized by hypertension><pregnancy diabetes><pregnancy disorder><pregnancy hypertension><pregnancy-related complications><pregnancy-related hypertension><premature age of menopause><premature childbirth><premature delivery><premenopausal status><preterm delivery><racial population><racial subgroup><reproductive><reproductive age><reproductive outcome><reproductive years><social><social climate><social context><social cultural factor><social culture><social culture determinant><socio-cultural><socio-economic disadvantage><socio-economically disadvantaged><socio-economically underprivileged><sociocultural><sociocultural determinant><sociocultural factor><socioeconomic disadvantage><socioeconomically underprivileged><socioenvironment><socioenvironmental><stressor><tool><transition to menopause><transitional menopause><type 2 DM><type II DM><type two diabetes><women at high risk>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sungmin Nam

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 26/100

Solid budget

Active award

$284,108

FY 2026

Project Title

Exploring the Impact of Aging-Related Mechanical Changes in the Brain on Microglial Activities and Their Implications for Alzheimer's Disease Progression

Grant Number:

1R03AG093279-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2027

Project Abstract

Alzheimer’s disease (AD) is the most prevalent neurodegenerative condition, with its effects becoming more pronounced with age, suggesting that aging is a critical factor in its development. Recent clinical observations have identified significant mechanical changes in the aging brain, including dec...

Research Terms

<3-D><3-Dimensional><3D><AD dementia><AD pathology><Abeta clearance><Acceleration><Active Oxygen><Adhesions><Affect><Age><Aging><Alginates><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease pathology><Alzheimer's pathology><Alzheimers Dementia><Amentia><Amyloid (Aβ) plaques><Amyloid Plaques><Amyloid β clearance><Assay><Autoregulation><Aβ clearance><Behavior><Bioassay><Biochemical><Biological Assay><Biological Function><Biological Process><Biomechanics><Biophysical Process><Body Tissues><Brain><Brain Nervous System><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell-Extracellular Matrix><Cells><Cellular Function><Cellular Mechanotransduction><Cellular Physiology><Cellular Process><Characteristics><Chronic><Clinical><Clinical Research><Clinical Study><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communication><Complex><Connective Tissue><Cues><Degenerative Neurologic Disorders><Dementia><Development><Diagnostic><Disease Progression><Disturbance in cognition><ECM><Elderly><Encephalon><Engineering><Environment><Exhibits><Extracellular Matrix><Foundations><Genetic><Glycoprotein GP-2><Goals><Health><Homeostasis><Hortega cell><Hyaluronic Acid><Hydrogels><Image><Immune><Immunes><Impaired cognition><Incidence><Inflammation><Inflammatory><Inflammatory Response><Integrins><Integrins Extracellular Matrix><Investigation><Ion Channel><Ionic Channels><Laminin><Mechanical Signal Transduction><Mechanics><Mechanosensory Transduction><Mediating><Membrane Channels><Memory Loss><Microglia><Modeling><Molecular><Morphology><Natural regeneration><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuritic Plaques><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurofibrillary Tangles><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Oxygen Radicals><Pathogenesis><Pathway interactions><Phagocytosis><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Play><Primary Senile Degenerative Dementia><Pro-Oxidants><Process><Property><Reactive Oxygen Species><Recreation><Regeneration><Research><Risk Factors><Role><Senile Plaques><Severities><Shapes><Signal Pathway><Stretching><Structure><Subcellular Process><Synapses><Synaptic><System><Testing><Therapeutic><Time><Tissues><Variant><Variation><Work><a-beta peptide clearance><abeta peptide clearance><advanced age><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age related alterations><age related changes><age specific alterations><age specific changes><aged brain><ages><aging associated><aging associated alterations><aging associated changes><aging brain><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><amyloid beta clearance><amyloid beta peptide clearance><amyloid beta plaque><amyloid-b plaque><aβ plaques><biomechanical><biophysical mechanism><brain cell><brain health><cell behavior><cellular behavior><changes with age><cognitive dysfunction><cognitive loss><cored plaque><cytokine><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><diffuse plaque><geriatric><gitter cell><glial activation><glial cell activation><imaging><in vitro Model><inhibitor><innovate><innovation><innovative><insight><interdisciplinary approach><live cell image><live cell imaging><live cellular image><live cellular imaging><mechanic><mechanical><mechanical cue><mechanical drive><mechanical properties><mechanical signal><mechanosensing><mechanotransduction><memory decline><mesoglia><microglial cell><microgliocyte><migration><multidisciplinary approach><neural><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurological degeneration><neuronal><neuronal degeneration><neuroprotection><neuroprotective><neurotoxic><novel><pathway><perivascular glial cell><pharmacologic><primary degenerative dementia><regenerate><repair><repaired><response><senile dementia of the Alzheimer type><senior citizen><social role><synapse><tangle><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><three dimensional><transcriptomics><viscoelasticity>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

BRADLEY T. HYMAN

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 26/100

Solid budget

Active award

$268,680

FY 2026

Project Title

MGH Diseases of Aging Pathway Via Stimulating Access to Research in Residency (MGH DAP StARR)

Grant Number:

5R38AG070229-04

Activity Code:

R38

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/15/2023

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY Physician-scientists play a unique role in bridging the gap between basic science and clinicians through the identification of important clinical questions and translating results to improve patient care. Regrettably, the physician-scientist workforce has continued to diminish, which...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><ADRD><Address><Adult><Adult Human><Aging><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Amentia><Area><Basic Research><Basic Science><Bioinformatics><Biological Markers><Biomedical Research><Boston><Cardiovascular Diseases><Clinical><Clinical Medical Sciences><Clinical Medicine><Clinical Research><Clinical Study><Communication><Communities><Coupled><Dedications><Degenerative Neurologic Disorders><Dementia><Development><Doctor's Assistants><Dysfunction><Early Diagnosis><Environment><Faculty><Fellowship><Financial Hardship><Fostering><Foundations><Functional disorder><Funding><Future><Gastrointestinal Diseases><General Hospitals><General Population><General Public><Goals><Health><Hospitalists><Individual><Inpatients><Institution><Intellectual Curiosity><Intellectual Interest><Investigation><Investigators><Knowledge><Laboratories><Laboratory Research><Leadership><Life><Link><Massachusetts><Measures><Medical><Medicine><Mentors><Mentorship><Metabolic Diseases><Metabolic Disorder><Methodology><Modeling><Muscle Disease><Muscle Disorders><Muscular Diseases><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurology><Paralysis Agitans><Parkinson><Parkinson Disease><Participant><Pathway interactions><Patient Care><Patient Care Delivery><Patients><Physician Assistants><Physicians><Physicians' Extenders><Physiopathology><Play><Preparedness><Prevalence><Preventive><Primary Parkinsonism><Productivity><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><Readiness><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Residencies><Role><Science><Scientist><Solid><Specific qualifier value><Specified><Structure><Therapeutic><Thesaurismosis><Time><Training><Training Programs><Translating><Translational Research><Translational Science><Work><adulthood><age associated><age correlated><age dependent><age linked><age related><age related pathways><age specific><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging associated disease><aging associated disorders><aging associated mechanism><aging mechanism><aging pathway><aging population><aging related disease><aging related disorders><aging related mechanism><aging related pathways><apprentice><apprenticeship><bio-markers><biologic marker><biological mechanism of age><biological pathways of age><biomarker><cardiovascular disorder><care for patients><care of patients><career><caring for patients><clinical investigation><conference><convention><cost><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><diagnostic tool><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><early detection><economic hardship><economic strain><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><frailty><gastrointestinal disorder><image-based method><imaging method><imaging modality><implementation strategy><improved><innovate><innovation><innovative><interest><mechanism regulating aging><mechanisms involved in aging><metabolism disorder><multidisciplinary><multimorbidity><multiple chronic conditions><muscular disorder><neurodegenerative illness><new drug treatments><new drugs><new pharmacological therapeutic><new technology><new therapeutics><new therapy><next generation><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel technologies><novel therapeutics><novel therapy><pathophysiology><pathway><pathway involved in aging><population aging><programs><role model><skeletal disease><skeletal disorder><skill acquisition><skill development><skills><social role><statistics><strategies for implementation><summit><symposia><symposium><tool><translation research><translational investigation>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Christine S Ritchie

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 26/100

Solid budget

Active award

$268,680

FY 2026

Project Title

MGH Diseases of Aging Pathway Via Stimulating Access to Research in Residency (MGH DAP StARR)

Grant Number:

5R38AG070229-04

Activity Code:

R38

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/15/2023

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY Physician-scientists play a unique role in bridging the gap between basic science and clinicians through the identification of important clinical questions and translating results to improve patient care. Regrettably, the physician-scientist workforce has continued to diminish, which...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><ADRD><Address><Adult><Adult Human><Aging><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Amentia><Area><Basic Research><Basic Science><Bioinformatics><Biological Markers><Biomedical Research><Boston><Cardiovascular Diseases><Clinical><Clinical Medical Sciences><Clinical Medicine><Clinical Research><Clinical Study><Communication><Communities><Coupled><Dedications><Degenerative Neurologic Disorders><Dementia><Development><Doctor's Assistants><Dysfunction><Early Diagnosis><Environment><Faculty><Fellowship><Financial Hardship><Fostering><Foundations><Functional disorder><Funding><Future><Gastrointestinal Diseases><General Hospitals><General Population><General Public><Goals><Health><Hospitalists><Individual><Inpatients><Institution><Intellectual Curiosity><Intellectual Interest><Investigation><Investigators><Knowledge><Laboratories><Laboratory Research><Leadership><Life><Link><Massachusetts><Measures><Medical><Medicine><Mentors><Mentorship><Metabolic Diseases><Metabolic Disorder><Methodology><Modeling><Muscle Disease><Muscle Disorders><Muscular Diseases><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurology><Paralysis Agitans><Parkinson><Parkinson Disease><Participant><Pathway interactions><Patient Care><Patient Care Delivery><Patients><Physician Assistants><Physicians><Physicians' Extenders><Physiopathology><Play><Preparedness><Prevalence><Preventive><Primary Parkinsonism><Productivity><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><Readiness><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Residencies><Role><Science><Scientist><Solid><Specific qualifier value><Specified><Structure><Therapeutic><Thesaurismosis><Time><Training><Training Programs><Translating><Translational Research><Translational Science><Work><adulthood><age associated><age correlated><age dependent><age linked><age related><age related pathways><age specific><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging associated disease><aging associated disorders><aging associated mechanism><aging mechanism><aging pathway><aging population><aging related disease><aging related disorders><aging related mechanism><aging related pathways><apprentice><apprenticeship><bio-markers><biologic marker><biological mechanism of age><biological pathways of age><biomarker><cardiovascular disorder><care for patients><care of patients><career><caring for patients><clinical investigation><conference><convention><cost><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><diagnostic tool><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><early detection><economic hardship><economic strain><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><frailty><gastrointestinal disorder><image-based method><imaging method><imaging modality><implementation strategy><improved><innovate><innovation><innovative><interest><mechanism regulating aging><mechanisms involved in aging><metabolism disorder><multidisciplinary><multimorbidity><multiple chronic conditions><muscular disorder><neurodegenerative illness><new drug treatments><new drugs><new pharmacological therapeutic><new technology><new therapeutics><new therapy><next generation><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel technologies><novel therapeutics><novel therapy><pathophysiology><pathway><pathway involved in aging><population aging><programs><role model><skeletal disease><skeletal disorder><skill acquisition><skill development><skills><social role><statistics><strategies for implementation><summit><symposia><symposium><tool><translation research><translational investigation>

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Jatin M Vyas

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 26/100

Solid budget

Active award

$268,680

FY 2026

Project Title

MGH Diseases of Aging Pathway Via Stimulating Access to Research in Residency (MGH DAP StARR)

Grant Number:

5R38AG070229-04

Activity Code:

R38

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/15/2023

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY Physician-scientists play a unique role in bridging the gap between basic science and clinicians through the identification of important clinical questions and translating results to improve patient care. Regrettably, the physician-scientist workforce has continued to diminish, which...

Research Terms

<21+ years old><AD and related dementia><AD related dementia><ADRD><Address><Adult><Adult Human><Aging><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Amentia><Area><Basic Research><Basic Science><Bioinformatics><Biological Markers><Biomedical Research><Boston><Cardiovascular Diseases><Clinical><Clinical Medical Sciences><Clinical Medicine><Clinical Research><Clinical Study><Communication><Communities><Coupled><Dedications><Degenerative Neurologic Disorders><Dementia><Development><Doctor's Assistants><Dysfunction><Early Diagnosis><Environment><Faculty><Fellowship><Financial Hardship><Fostering><Foundations><Functional disorder><Funding><Future><Gastrointestinal Diseases><General Hospitals><General Population><General Public><Goals><Health><Hospitalists><Individual><Inpatients><Institution><Intellectual Curiosity><Intellectual Interest><Investigation><Investigators><Knowledge><Laboratories><Laboratory Research><Leadership><Life><Link><Massachusetts><Measures><Medical><Medicine><Mentors><Mentorship><Metabolic Diseases><Metabolic Disorder><Methodology><Modeling><Muscle Disease><Muscle Disorders><Muscular Diseases><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurology><Paralysis Agitans><Parkinson><Parkinson Disease><Participant><Pathway interactions><Patient Care><Patient Care Delivery><Patients><Physician Assistants><Physicians><Physicians' Extenders><Physiopathology><Play><Preparedness><Prevalence><Preventive><Primary Parkinsonism><Productivity><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><Readiness><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Residencies><Role><Science><Scientist><Solid><Specific qualifier value><Specified><Structure><Therapeutic><Thesaurismosis><Time><Training><Training Programs><Translating><Translational Research><Translational Science><Work><adulthood><age associated><age correlated><age dependent><age linked><age related><age related pathways><age specific><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><aging associated disease><aging associated disorders><aging associated mechanism><aging mechanism><aging pathway><aging population><aging related disease><aging related disorders><aging related mechanism><aging related pathways><apprentice><apprenticeship><bio-markers><biologic marker><biological mechanism of age><biological pathways of age><biomarker><cardiovascular disorder><care for patients><care of patients><career><caring for patients><clinical investigation><conference><convention><cost><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><diagnostic tool><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><early detection><economic hardship><economic strain><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><frailty><gastrointestinal disorder><image-based method><imaging method><imaging modality><implementation strategy><improved><innovate><innovation><innovative><interest><mechanism regulating aging><mechanisms involved in aging><metabolism disorder><multidisciplinary><multimorbidity><multiple chronic conditions><muscular disorder><neurodegenerative illness><new drug treatments><new drugs><new pharmacological therapeutic><new technology><new therapeutics><new therapy><next generation><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel technologies><novel therapeutics><novel therapy><pathophysiology><pathway><pathway involved in aging><population aging><programs><role model><skeletal disease><skeletal disorder><skill acquisition><skill development><skills><social role><statistics><strategies for implementation><summit><symposia><symposium><tool><translation research><translational investigation>

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Reem Waziry

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 22/100

Recent

Active award

$249,000

FY 2026

Project Title

Biological Aging, the Proteome and Cognitive Resilience among Ischemic Stroke Survivors

Grant Number:

4R00AG075196-03

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2023

End Date:

12/31/2028

Project Abstract

To date there is no disease-modifying therapy for cognitive impairment and dementia. Understanding mechanisms that strengthen cognitive resilience and delay vascular dementia is a complimentary approach to protect cognitive health in aging. Survivors of stroke and vascular disorders are rapidly grow...

Research Terms

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XIAO TIAN

SANFORD BURNHAM PREBYS MEDICAL DISCOVERY INSTITUTE, LA JOLLA, CA

Exploratory lead · 22/100

Recent

Active award

$248,999

FY 2026

Project Title

Epigenetic Reprogramming to Counteract Neuronal Aging and Degeneration

Grant Number:

5R00AG068303-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2020

End Date:

1/31/2027

Project Abstract

Project Summary/Abstract The aging brain is increasingly susceptible to cognitive decline and dementia. Alzheimer’s disease (AD), a main form of dementia, is an extreme, pathological manifestation of brain aging. However, the etiology and pathogenesis of AD are not well understood, causing the deart...

Research Terms

<21+ years old><AD dementia><APP-PS1><APP/PS1><Acute><Adeno-Associated Viruses><Adult><Adult Human><Age><Age associated cognitive deficit><Age associated cognitive dysfunction><Age related memory decline><Age related memory deficit><Age related memory impairment><Age-associated cognitive decline><Age-related cognitive decline><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Ammon Horn><Area><Award><Axon><Behavioral><Benign senescent forgetfulness><Bioinformatics><Birth><Blindness><Brain><Brain Nervous System><Brain region><Breeding><CNS Nervous System><CNS degeneration><CNS plasticity><Candidate Disease Gene><Candidate Gene><Causality><Cell Body><Cell Cycle><Cell Division Cycle><Cell Survival><Cell Viability><Cells><Central Nervous System><Characteristics><Chemicals><Chronic><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Collaborations><Complex><Consultations><Cornu Ammonis><Cranial Nerve II><Crossbreeding><Crush Injury><DNA><DNA Methylation><Data><Degenerative Neurologic Disorders><Dementia><Deoxyribonucleic Acid><Dependoparvovirus><Dependovirus><Deterioration><Development Plans><Disease><Disorder><Disturbance in cognition><Ectopic Expression><Electrophysiology><Electrophysiology (science)><Encephalon><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Family Health><Family health status><Fore-Brain><Forebrain><Gene Expression><Gene Inactivation><Gene Silencing><Genetic Hybridization><Hippocampus><Histologic><Histologic Technics><Histologic Techniques><Histological Technics><Histological Techniques><Histologically><Histone Acetylation><Histones><Impaired cognition><Impairment><In Vitro><Incidence><Injury><Knowledge><Learning><Leurocristine><Link><Mammalia><Mammals><Mediating><Memory><Mentors><Mentorship><Mice><Mice Mammals><Modeling><Molecular><Murine><Mus><Nature><Nerve Cells><Nerve Degeneration><Nerve Regeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neuro-regeneration><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neuronal Plasticity><Neurons><Neuropathy><Neurophysiology / Electrophysiology><Neuroregeneration><Neurosciences><Optic Nerve><Parturition><Pathogenesis><Pathologic><Patients><Phase><Physiologic><Physiological><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Predisposition><Primary Senile Degenerative Dementia><Property><Prosencephalon><Protein Modification><Public Health><RNA Seq><RNA sequencing><RNAseq><Regenerative capacity><Rejuvenation><Research><Retina><Retinal Ganglion Cells><Retrieval><Role><Second Cranial Nerve><Structure><Susceptibility><Synaptic plasticity><System><Technology><Testing><Tetracyclines><Therapeutic><Therapeutic Effect><Training><Vincristine><Vincrystine><Work><aberrant aging><abnormal aging><adeno associated virus group><adulthood><age associated cognitive impairment><age associated disease><age associated disorder><age associated impairment><age associated memory decline><age associated memory deficit><age dependent disease><age dependent disorder><age dependent impairment><age related cognitive deficit><age related cognitive dysfunction><age related cognitive impairment><age related human disease><age related memory dysfunction><age reversal><age-associated memory impairment><age-induced cognitive decline><age-related decline in cognition><age-related decline in cognitive function><age-related disease><age-related disorder><age-related impairment><aged><aged brain><aged mice><aged mouse><ages><aging associated><aging brain><aging related><aging related cognitive decline><aging reversal><alleviate age related><alleviate aging><ameliorating aging><axon regeneration><axonal degeneration><axonal regeneration><behavior test><behavioral test><career development><causation><cell age><cellular age><central nervous system degeneration><central nervous system plasticity><cognitive dysfunction><cognitive function><cognitive loss><consultation><counter age related><counter aging><counteract age related><counteract aging><decline in function><decline in functional status><declining cognitive functions with aging><degenerative axon><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><disease causation><dysfunctional age related change><dysfunctional aging><effective therapy><effective treatment><elderly mice><electrophysiological><epigenetically><epigenome><epigenomics><experiment><experimental research><experimental study><experiments><functional decline><functional status decline><genome scale><genome wide analysis><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><global gene expression><global transcription profile><hippocampal><impaired aging><improved><inhibitor><injuries><insight><maladaptive aging><medical college><medical schools><methylomics><mouse model><murine model><nerve cell death><nerve cell loss><nervous system regeneration><neural degeneration><neural plasticity><neural regeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuron regeneration><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neuronal regeneration><neuronal survival><neuropathic><neurophysiological><neurophysiology><neuroplastic><neuroplasticity><neuroregenerative><novel><old mice><oxovincaleukoblastine><pathological age related changes><pathological aging><postmitotic><prevent><preventing><primary degenerative dementia><programs><regenerated nerve><regeneration ability><regeneration capacity><restore sight><restore vision><retinal ganglion><reverse age><reverse aging><reverse aging effects><reversible aging><school of medicine><senile dementia of the Alzheimer type><sight restoration><social role><therapeutic evaluation><therapeutic testing><transcriptional silencing><transcriptome><transcriptome sequencing><transcriptomic sequencing><vision loss><vision restoration><visual loss>

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Katherine A Moon

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Exploratory lead · 22/100

Recent

Active award

$242,261

FY 2026

Project Title

The role of toxic and essential metal mixtures, and co-exposures to social stressors, in cognitive aging, mild cognitive impairment, and novel epigenetic age biomarkers: The Baltimore Memory Study

Grant Number:

5R00ES031998-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/13/2021

End Date:

2/28/2027

Project Abstract

PROJECT SUMMARY Environmental toxicants are understudied modifiable risk factors for cognitive decline and dementia. Toxic metals, and some essential trace elements, are well-known neurotoxicants and have been linked to cognitive decline. Evaluating the joint actions of environmental exposures may e...

Research Terms

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Alexi L Vasbinder

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 22/100

Recent

Active award

$145,716

FY 2026

Project Title

Epigenetics, accelerated aging, and cardiovascular health during breast cancer treatment

Grant Number:

5R21CA300956-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/17/2025

End Date:

2/28/2027

Project Abstract

PROJECT SUMMARY Although survival from breast cancer (BC) has improved, BC treatment is associated with an increased risk of cardiovascular (CV) complications due in part to the cardiotoxic effects of BC treatment. BC treatments are also linked to reduced exercise capacity and cardiac function, whic...

Research Terms

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Pankaj Kapahi

BUCK INSTITUTE FOR RESEARCH ON AGING, NOVATO, CA

Exploratory lead · 22/100

Recent

Active award

$99,788

FY 2026

Project Title

Summer Training Course in Experimental Aging

Grant Number:

5R13AG059431-08

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2018

End Date:

2/28/2030

Project Abstract

Project Summary This Summer Training Course (STC) will be held for five days each June from 2025 through 2029. The STC will be directed by Drs. Kapahi and Hansen at the Buck Institute for Aging Research. The course site will rotate among three host institutions: Buck Institute for Research on Aging ...

Research Terms

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MITCHELL S SOMMERS

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 22/100

Recent

Active award

$53,461

FY 2026

Project Title

Cognition Aging and Speech Communication Conference

Grant Number:

1R13AG094200-01A1

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2027

Project Abstract

This application seeks funding to continue a series of international and interdisciplinary research conferences on cognition, speech communication and aging. Scientists approaching this problem have typically been working in the areas of sensory and perceptual processing, especially hearing, cogniti...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Age><Aging><Agreement><Amentia><American><Animals><Anxiety><Applications Grants><Area><Assistive Technology><Audiology><Auditory><Auditory Perception><Auditory Physiology><Brain imaging><Canada><Cancers><Chronic><Clinical><Cognition><Cognitive><Cognitive Science><Collaborations><Communication><Communication challenge><Communication difficulty><Dementia><Diabetes Mellitus><Discipline><Elderly><Environment><Feedback><Funding><Future><Grant Proposals><Head><Health><Health Care Costs><Health Costs><Hearing><Hearing Aids><Hearing Loss><Human><Hypoacuses><Hypoacusis><Individual><Interdisciplinary Research><Interdisciplinary Study><International><Investigators><Knowledge><Learning><Letters><Malignant Neoplasms><Malignant Tumor><Mediating><Mental Depression><Methodology><Modeling><Modern Man><Multidisciplinary Collaboration><Multidisciplinary Research><Neurosciences><Noise><Oral><Perception><Persons><Process><Production><Psychology><QOL><Quality of life><Research><Research Personnel><Researchers><Scholarship><Science><Scientist><Self-Help Devices><Sensory><Series><Speech><Speech Perception><Students><Sweden><System><Time><United States><Universities><Washington><adulthood><advanced age><age associated><age associated alterations><age associated changes><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age specific><age specific alterations><age specific changes><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><assisted device><assistive device><assistive hearing device><assistive listening device><awake><base><bases><brain visualization><changes with age><cognitive psychology><conference><convention><depression><design><designing><diabetes><dysfunctional hearing><falls><geriatric><hearing amplification><hearing assistance><hearing assistive device><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing device><hearing difficulty><hearing dysfunction><hearing impairment><hearing in noise><hearing perception><improved><indexing><insight><life span><lifespan><malignancy><member><multisensory><neoplasm/cancer><neural><neurophysiological><neurophysiology><older adult><older adulthood><pandemic><pandemic disease><posters><programs><satisfaction><senior citizen><sound perception><speech in background noise><speech in noise><speech in speech recognition><speech recognition in noise><success><summit><symposia><symposium><theories>

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HOLLY M. BROWN-BORG

UNIVERSITY OF NORTH DAKOTA, GRAND FORKS, ND

Exploratory lead · 22/100

Recent

Active award

$50,000

FY 2026

Project Title

Sixteenth and Seventeenth International Symposia on Neurobiology and Neuroendocrinology of Aging

Grant Number:

5R13AG085942-03

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2026

Project Abstract

The Sixteenth and Seventeenth International Symposia on Neurobiology & Neuroendocrinology Aging will be held in Bregenz, Austria, July 12-16, 2024, and in July 2026. The purpose of these meetings is to bring together a group of investigators who made recent advances in the study of mechanisms of agi...

Research Terms

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Alison Drake Klein

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Exploratory lead · 22/100

Recent

Active award

$3,000

FY 2026

Project Title

Lysosome homeostasis in aging-related diseases

Grant Number:

3F99AG095027-01S1

Activity Code:

F99

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/22/2025

End Date:

9/21/2027

Project Abstract

Abstract Lysosomes are important for maintaining cellular health and their dysfunction is linked to numerous aging-related diseases. Lysosome function is regulated by homeostatic mechanisms that allow cells to sense lysosomal stress and either eliminate or repair damaged lysosomes, or generate new l...

Research Terms

<21+ years old><Adult><Adult Human><Aging><Animal Model><Animal Models and Related Studies><Autophagocytosis><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Biochemical><Biogenesis><Body Tissues><Catalogs><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Complex><Cytoplasm><DA Neuron><DNA mutation><Degenerative Disorder><Degenerative Neurologic Disorders><Development><Development Plans><Development and Research><Disease><Disorder><Dopamine neuron><Dysfunction><Environment><Equilibrium><Failure><Fishes><Functional disorder><Gene Alteration><Gene Mutation><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generations><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Goals><Health><Homeostasis><Individual><Induced pluripotent stem cell derived neurons><Intracellular Communication and Signaling><Kinases><Knowledge><Link><Lysosomes><MSKCC><Maintenance><Mediating><Membrane><Memorial Sloan-Kettering Cancer Center><Mentorship><Mice><Mice Mammals><Microscopy><Modeling><Modification><Murine><Mus><Mutation><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurodevelopmental Disorder><Neurologic Degenerative Conditions><Neurological Development Disorder><Neuron Degeneration><Neuron from iPSC><Neuron from induced pluripotent stem cells><Neurons><Nutrient><Organelles><Origin of Life><Output><Paralysis Agitans><Parkinson><Parkinson Disease><Pathway interactions><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Postdoc><Postdoctoral Fellow><Predisposition><Primary Parkinsonism><Process><Proteins><R & D><R&D><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Expression><Recycling><Regulation><Research><Research Associate><Research Grants><Research Project Grants><Research Projects><Research Resources><Resources><Role><Signal Transduction><Signal Transduction Systems><Signaling><Stress><Supporting Cell><Susceptibility><Testing><Therapeutic><Tissues><Training><Transcription><Transcription Activation><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activation><Transphosphorylases><Work><adulthood><aging associated><aging associated disease><aging associated disorders><aging related><aging related disease><aging related disorders><autophagy><balance><balance function><biological adaptation to stress><biological signal transduction><career development><catalog><cell type><degenerative condition><degenerative disease><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><disease associated with aging><disease model><disease of aging><disorder model><disorder of aging><disorders associated with aging><disorders related to aging><dopaminergic neuron><experiment><experimental research><experimental study><experiments><extracellular><fitness><gene defect><genome mutation><graduate school><human disease><iPS><iPS neurons><iPSC><iPSC derived-neurons><iPSCs><induced pluripotent cell><induced pluripotent stem cell><induced pluripotent stem cell neurons><inducible pluripotent cell><inducible pluripotent stem cell><insight><insoluble aggregate><membrane structure><model of animal><mutant allele><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurodevelopmental disease><neurological degeneration><neuronal><neuronal degeneration><neurons derived from induced pluripotent stem cells><neurons differentiated from induced pluripotent stem cells><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathophysiology><pathway><physiologic model><post-doc><post-doctoral><post-doctoral trainee><pre-doc><pre-doctoral><programs><protein aggregate><protein aggregation><reactioncrisis><repair><repaired><research and development><research associates><response><scaffold><scaffolding><social role><stress response><stressreaction><trafficking><transcription factor>

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Haopeng Xiao

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 16/100

Active award

$248,354

FY 2026

Project Title

Defining the landscape and mechanisms of redox regulation of metabolism during aging

Grant Number:

5R00AG073461-04

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2022

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY: Mammalian tissues engage in specialized physiology that is regulated through reversible modification of protein cysteine residues by reactive oxygen species (ROS). Despite the longstanding links between ROS dysregulation and aging, technological limitations have resulted in a persis...

Research Terms

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Thomas Stoeger

NORTHWESTERN UNIVERSITY, Chicago, IL

Exploratory lead · 16/100

Active award

$234,812

FY 2026

Project Title

Integrative Multi-Scale Systems Analysis of Gene-Expression-Driven Aging Morbidity

Grant Number:

5R00AG068544-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2020

End Date:

12/31/2026

Project Abstract

Project Summary In a well-received preprint, the investigator identified through unbiased analysis of own and published datasets that during aging, and infection of the lung with influenza A, there is a progressive imbalance in the transcript levels encoded by short genes relative to those encoded b...

Research Terms

<21+ years old><Address><Adult><Adult Human><Aging><Area><Autoregulation><Biochemical><Bioethics><Biology of Aging><Biomedical Ethics><Body Tissues><Brain><Brain Nervous System><Buffers><Cause of Death><Cell Function><Cell Line><Cell Physiology><Cell Process><CellLine><Cellular Function><Cellular Immune Function><Cellular Physiology><Cellular Process><Cellular Stress><Cellular Stress Response><Cellular biology><Collaborations><Communicable Diseases><Complex><Data><Data Science><Data Scientist><Data Set><Disease><Disorder><Drug Screening><Dysfunction><Economic Burden><Elderly><Elements><Embryo><Embryonic><Encephalon><Ensure><Epithelium><Failure><Foundations><Functional disorder><Funding><GTEx><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><Genes><Genetic Transcription><Genome><Genotype-Tissue Expression Project><Geroscience><Gln><Global Change><Glutamine><Grant><Health><Heat Shock><Heat-Shock Reaction><Heat-Shock Response><Heterozygote><Homeostasis><Human><Human Cell Line><Immune><Immunes><Immunologist><Impairment><In Vitro><Individual><Infection><Infectious Diseases><Infectious Disorder><Inflammatory Response><Influenza A><Influenza A virus><Influenza Viruses Type A><Influenzavirus A><Intervention Strategies><Investigators><L-Glutamine><L-Proline><Laboratories><Lead><Learning><Learning Skill><Length><Life><Link><Lung><Lung Diseases><Lung Respiratory System><Lung infections><Machine Learning><Macromolecular Complexes><Mentors><Mentorship><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Morbidity><Murine><Mus><Non-Polyadenylated RNA><Older Population><Organ><Orthomyxovirus Type A><Pathway interactions><Pb element><Phase><Physiological Homeostasis><Physiopathology><Pneumonia><Polymerase><Postdoc><Postdoctoral Fellow><Predisposition><Printing><Process><Proline><Proteome><Publishing><Pulmonary Diseases><Pulmonary Disorder><Q Levoglutamide><Q. Levoglutamide><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA Splicing><RNA metabolism><RNA sequencing><RNAseq><Recovery><Regulation><Reporting><Research><Research Associate><Research Personnel><Researchers><Ribonucleic Acid><Running><Scientist><Site><Splicing><Stimulus><Strains Cell Lines><Stress><Subcellular Process><Supervision><Susceptibility><System><Systems Analyses><Systems Analysis><Techniques><Testing><Tissues><Training><Training Programs><Transcript><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Type A Influenza><United States><Upregulation><Viral Diseases><Virus Diseases><Work><Writing><aberrant aging><abnormal aging><adulthood><advanced age><age associated><age associated alterations><age associated changes><age associated decline><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent decline><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related decline><age specific><age specific alterations><age specific changes><aged><aged animal><aged animals><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging morbidity><aging population><aging related alterations><aging related changes><aging resilience><aging specific alterations><aging specific changes><alterations with age><analyze gene expression><animal old age><biological adaptation to stress><cell age><cell biology><cell stress><cellular age><changes with age><cultured cell line><decline with age><disease of the lung><disorder of the lung><dysfunctional age related change><dysfunctional aging><elderly animal><elderly mice><enhance healthspan><extend healthspan><extending healthy lifespan><flu infection><flu virus infection><gene expression analysis><gene expression assay><genome scale><genome-wide><genomewide><geriatric><geroscientific><global gene expression><global transcription profile><healthspan extension><heavy metal Pb><heavy metal lead><heterozygosity><immune function><impaired aging><improve healthspan><in vivo><in vivo Model><increase healthspan><infected with flu><infected with flu virus><infected with influenza><infected with influenza virus><influenza A pneumonia><influenza infection><influenza virus infection><innovate><innovation><innovative><interest><loss of function><lung disorder><machine based learning><maladaptive aging><mortality><mouse model><multimorbidity><multiple chronic conditions><murine model><natural aging><new approaches><normal aging><normative aging><novel><novel approaches><novel strategies><novel strategy><old animals><old mice><older groups><older individuals><older person><overexpress><overexpression><pathological age related changes><pathological aging><pathophysiology><pathway><pneumonia model><pneumonia models><population aging><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><programs><prolong healthspan><promote healthspan><protein homeostasis><proteostasis><pulmonary infections><reactioncrisis><research associates><resilience><resilience during aging><resilience in aging><resilience in normal aging><resilience to aging><resilience with aging><resilient><resilient aging><resilient to aging><response><senior citizen><social><stoichiometry><stress response><stressreaction><transcriptional profiling><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><viral infection><virus infection><virus-induced disease>

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Charles P Najt

VIRGINIA POLYTECHNIC INST AND ST UNIV, BLACKSBURG, VA

Exploratory lead · 16/100

Active award

$228,098

FY 2026

Project Title

Perilipin 5: Linking lipid droplets to nutrient sensing and healthy aging

Grant Number:

5R00AG070104-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY Nutrient sensing pathways (mTOR, AMPK, sirtuins) are core components underlying the aging process, linking post-translation modifications critical to cellular function to environmental factors. To date, research in this area has largely focused on interventions such as caloric or pro...

Research Terms

<3'5'-cyclic ester of AMP><Ablation><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine Cyclic Monophosphate-Dependent Protein Kinases><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adipose tissue><Aging><Area><Autophagocytosis><Binding><Biogenesis><Biology><Biotin><Body Tissues><CRISPR><CRISPR/Cas system><Caloric Restriction><Catabolism><Cell Body><Cell Communication and Signaling><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cell Respiration><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Respiration><Clustered Regularly Interspaced Short Palindromic Repeats><Couples><Cyclic AMP><Cyclic AMP-Dependent Protein Kinases><Cytoplasm><Data><Deacetylase><Development><Diet><Dietary Factors><Dietary Intervention><Environmental Factor><Environmental Risk Factor><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Fasting><Fats><Fatty Acids><Fatty Tissue><Fatty acid glycerol esters><Funding><Goals><Health><Health Benefit><Healthy diet><Inflammation><Intermittent fasting><Intervention><Intervention Studies><Intracellular Communication and Signaling><Investigators><Knock-out><Knockout><Knowledge><Length of Life><Life><Ligase><Ligase Gene><Link><Lipase><Lipid Trafficking><Lipids><Lipolysis><Literature><Longevity><Maps><Mechanistic Target of Rapamycin><Mediating><Mediterranean Diet><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic dysfunction><Mice><Mice Mammals><Mitochondria><Molecular Interaction><Monounsaturated Fatty Acids><Morbidity><Murine><Mus><Nuclear><Nucleus><Nutrient><Nutrition Interventions><Nutritional Interventions><Olive Oil><Olive oil preparation><Origin of Life><PKA><Pathway interactions><Physiologic><Physiological><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Protein Kinase A><Protein Modification><Proteins><Publishing><RAFT1><Research><Research Personnel><Researchers><Role><SIRT1><SIRT1 gene><Signal Transduction><Signal Transduction Systems><Signaling><Silent Mating Type Information Regulator 2-like Proteins><Sir2-like Proteins><Sirtuin 1><Sirtuins><Subcellular Process><Supplementation><Surface><Synthetases><Testing><Thesaurismosis><Time><Tissues><Triacylglycerol><Triacylglycerol Hydrolase><Triacylglycerol Lipase><Triacylglycerol acylhydrolase><Tributyrinase><Triglyceridase><Triglyceride Lipase><Triglycerides><Triolean Hydrolase><Vitamin H><Work><accelerated aging><accelerated biological age><accelerated biological aging><adenosine 3'5' monophosphate><adipose><aerobic metabolism><aerobic respiration><age acceleration><age associated><age correlated><age dependent><age linked><age related><age specific><aging associated><aging delay><aging process><aging related><attenuate aging><autophagy><balanced diet><biological signal transduction><cAMP><cAMP-Dependent Protein Kinases><calorie restriction><coenzyme R><decelerate aging><delay age related><detection of nutrient><developmental><diet intervention><dietary><diets><enhance healthspan><environmental risk><epidemiology research study><epidemiology study><epidemiology survey><extend healthspan><extending healthy lifespan><fasted><fasts><fat metabolism><flexibility><flexible><good diet><healthspan><healthspan extending intervention><healthspan extending therapies><healthspan extension><healthspan intervention><healthspan promoting intervention><healthspan promoting therapies><healthspan therapies><healthy aging><healthy aging intervention><healthy human aging><healthy life span><improve healthspan><increase healthspan><interest><intervention research><intervention to promote healthy aging><interventional research><interventional study><interventions research><interventions to improve healthspan><life span><lifespan><lipid metabolism><lipid transport><mTOR><mammalian target of rapamycin><metabolism disorder><mid life><mid-life><middle age><middle aged><midlife><mitochondrial><model organism><novel><nutrient sensing><overexpress><overexpression><oxidative metabolism><pathway><pause aging><perception of nutrients><perilipin><postpone age related><prolong healthspan><promote healthspan><protective effect><response><retards aging><sensor><slow aging><slow down aging><slow the rate of aging><social role><synergism><tributyrase><white adipose tissue><yellow adipose tissue>

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Fernando Alonso Campos

UNIVERSITY OF TEXAS SAN ANTONIO, SAN ANTONIO, TX

Exploratory lead · 16/100

Active award

$196,999

FY 2026

Project Title

A new model system for assessing the socio-environmental determinants of the pace of aging: leveraging a long-term study of wild capuchins

Grant Number:

4R33AG078529-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2022

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY One of the most enduring questions in public health is why some individuals retain good health into old age while others experience declines in health, physical function, and wellbeing. Growing evidence indicates that socio-environmental factors can contribute to individual differenc...

Research Terms

<21+ years old><Address><Adrenal Glands><Adrenals><Adult><Adult Human><Age><Aging><Americas><Animal Model><Animal Models and Related Studies><Assessment instrument><Assessment tool><Back><Behavior assessment><Behavioral><Biologic Models><Biological><Biological Aging><Biological Markers><Biological Models><Birth><Body System><Brain><Brain Nervous System><Capuchin Monkey><Cebus><Cebus capucinus><Cebus imitator><Cellular Immune Function><Chronology><Complex><Costa Rica><Data><Data Collection><Data Set><Development><Diet Habits><Dietary Habits><Differences between sexes><Differs between sexes><Dimensions><Dorsum><Droughts><Elderly><Elderly Assessment><Encephalon><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Female><Fruit><GI microbiome><Gait speed><Generations><Geriatric Assessment><Health><Heterogeneity><Human><In Situ><Increase lifespan><Individual><Individual Differences><Inflammation><Knowledge><Laboratories><Life><Life Cycle><Life Cycle Stages><Life Expectancy><Life Experience><Life Style><Lifestyle><Link><Literature><Lived experience><Lived experiences><Long-term prospective studies><Longitudinal Studies><Longitudinal Surveys><Measures><Methods><Mission><Model System><Modeling><Modern Man><Molecular><Monitor><NIH><National Institutes of Health><Onset of illness><Organ System><Outcome><Parturition><Pattern><Pedigree><Personal Satisfaction><Phase><Phenotype><Physical Function><Physical environment><Physiologic><Physiological><Population><Position><Positioning Attribute><Primates><Primates Mammals><Probabilistic Models><Probability Models><Process><Productivity><Proteome><Public Health><Rain><Research><Sampling><Sex Differences><Sexual differences><Social Behavior><Social Environment><Source><Statistical Models><Techniques><Temperature><Testing><United States National Institutes of Health><Variant><Variation><Wild Animals><accelerated aging><accelerated biological age><accelerated biological aging><access to health care><accessibility of health care><accessibility to health care><adulthood><advanced age><age acceleration><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><ages><aging biological marker><aging biomarker><aging marker><aging process><analog><analyzing longitudinal><behavior measurement><behavior observation><behavioral assessment><behavioral measure><behavioral measurement><behavioral observation><bio-markers><biologic><biologic marker><biological process of age><biomarker><boost longevity><capuchin><developmental><dietary fruit><digestive tract microbiome><disease onset><disorder onset><disparity in health><eating habit><elongating the lifespan><enhance longevity><enteric microbiome><environmental risk><epigenetically><experience><extend life span><extend lifespan><extend longevity><field based data><field learning><field study><field test><foster longevity><gastrointestinal microbiome><genetic pedigree><geriatric><geriatric screening><gut microbiome><gut-associated microbiome><hallmarks of aging><health assessment><health care access><health care availability><health care service access><health care service availability><health disparity><healthspan><healthy life span><immune function><improve lifespan><improve longevity><individual heterogeneity><individual variability><individual variation><innovate><innovation><innovative><insight><intergenerational><intestinal biome><intestinal microbiome><life course><life history><life span><lifespan><lifespan extension><long-term study><longitudinal analysis><longitudinal outcome studies><longitudinal research study><longitudinal, prospective study><male><member><model of animal><molecular domain><natural aging><non-human primate><nonhuman primate><normal aging><normative aging><novel><old age><pace of aging><pace of biological aging><pedigree structure><physical conditioning><physical health><pillars of aging><population based><prolong lifespan><prolong longevity><promote lifespan><promote longevity><rainfall><rate of aging><rate of biological aging><senior citizen><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social><social adversity><social climate><social context><social group><social relationships><sociobehavior><sociobehavioral><socioenvironment><socioenvironmental><socioenvironmental factor><speed of aging><speed of the aging><statistical linear mixed models><statistical linear models><support longevity><suprarenal gland><trait><translational study><well-being><wellbeing><white-faced capuchin><white-throated capuchin><♀><♂>

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Katharine Mary Jack

UNIVERSITY OF TEXAS SAN ANTONIO, SAN ANTONIO, TX

Exploratory lead · 16/100

Active award

$196,999

FY 2026

Project Title

A new model system for assessing the socio-environmental determinants of the pace of aging: leveraging a long-term study of wild capuchins

Grant Number:

4R33AG078529-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2022

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY One of the most enduring questions in public health is why some individuals retain good health into old age while others experience declines in health, physical function, and wellbeing. Growing evidence indicates that socio-environmental factors can contribute to individual differenc...

Research Terms

<21+ years old><Address><Adrenal Glands><Adrenals><Adult><Adult Human><Age><Aging><Americas><Animal Model><Animal Models and Related Studies><Assessment instrument><Assessment tool><Back><Behavior assessment><Behavioral><Biologic Models><Biological><Biological Aging><Biological Markers><Biological Models><Birth><Body System><Brain><Brain Nervous System><Capuchin Monkey><Cebus><Cebus capucinus><Cebus imitator><Cellular Immune Function><Chronology><Complex><Costa Rica><Data><Data Collection><Data Set><Development><Diet Habits><Dietary Habits><Differences between sexes><Differs between sexes><Dimensions><Dorsum><Droughts><Elderly><Elderly Assessment><Encephalon><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Female><Fruit><GI microbiome><Gait speed><Generations><Geriatric Assessment><Health><Heterogeneity><Human><In Situ><Increase lifespan><Individual><Individual Differences><Inflammation><Knowledge><Laboratories><Life><Life Cycle><Life Cycle Stages><Life Expectancy><Life Experience><Life Style><Lifestyle><Link><Literature><Lived experience><Lived experiences><Long-term prospective studies><Longitudinal Studies><Longitudinal Surveys><Measures><Methods><Mission><Model System><Modeling><Modern Man><Molecular><Monitor><NIH><National Institutes of Health><Onset of illness><Organ System><Outcome><Parturition><Pattern><Pedigree><Personal Satisfaction><Phase><Phenotype><Physical Function><Physical environment><Physiologic><Physiological><Population><Position><Positioning Attribute><Primates><Primates Mammals><Probabilistic Models><Probability Models><Process><Productivity><Proteome><Public Health><Rain><Research><Sampling><Sex Differences><Sexual differences><Social Behavior><Social Environment><Source><Statistical Models><Techniques><Temperature><Testing><United States National Institutes of Health><Variant><Variation><Wild Animals><accelerated aging><accelerated biological age><accelerated biological aging><access to health care><accessibility of health care><accessibility to health care><adulthood><advanced age><age acceleration><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><ages><aging biological marker><aging biomarker><aging marker><aging process><analog><analyzing longitudinal><behavior measurement><behavior observation><behavioral assessment><behavioral measure><behavioral measurement><behavioral observation><bio-markers><biologic><biologic marker><biological process of age><biomarker><boost longevity><capuchin><developmental><dietary fruit><digestive tract microbiome><disease onset><disorder onset><disparity in health><eating habit><elongating the lifespan><enhance longevity><enteric microbiome><environmental risk><epigenetically><experience><extend life span><extend lifespan><extend longevity><field based data><field learning><field study><field test><foster longevity><gastrointestinal microbiome><genetic pedigree><geriatric><geriatric screening><gut microbiome><gut-associated microbiome><hallmarks of aging><health assessment><health care access><health care availability><health care service access><health care service availability><health disparity><healthspan><healthy life span><immune function><improve lifespan><improve longevity><individual heterogeneity><individual variability><individual variation><innovate><innovation><innovative><insight><intergenerational><intestinal biome><intestinal microbiome><life course><life history><life span><lifespan><lifespan extension><long-term study><longitudinal analysis><longitudinal outcome studies><longitudinal research study><longitudinal, prospective study><male><member><model of animal><molecular domain><natural aging><non-human primate><nonhuman primate><normal aging><normative aging><novel><old age><pace of aging><pace of biological aging><pedigree structure><physical conditioning><physical health><pillars of aging><population based><prolong lifespan><prolong longevity><promote lifespan><promote longevity><rainfall><rate of aging><rate of biological aging><senior citizen><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social><social adversity><social climate><social context><social group><social relationships><sociobehavior><sociobehavioral><socioenvironment><socioenvironmental><socioenvironmental factor><speed of aging><speed of the aging><statistical linear mixed models><statistical linear models><support longevity><suprarenal gland><trait><translational study><well-being><wellbeing><white-faced capuchin><white-throated capuchin><♀><♂>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Amanda Dawn Melin

UNIVERSITY OF TEXAS SAN ANTONIO, SAN ANTONIO, TX

Exploratory lead · 16/100

Active award

$196,999

FY 2026

Project Title

A new model system for assessing the socio-environmental determinants of the pace of aging: leveraging a long-term study of wild capuchins

Grant Number:

4R33AG078529-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2022

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY One of the most enduring questions in public health is why some individuals retain good health into old age while others experience declines in health, physical function, and wellbeing. Growing evidence indicates that socio-environmental factors can contribute to individual differenc...

Research Terms

<21+ years old><Address><Adrenal Glands><Adrenals><Adult><Adult Human><Age><Aging><Americas><Animal Model><Animal Models and Related Studies><Assessment instrument><Assessment tool><Back><Behavior assessment><Behavioral><Biologic Models><Biological><Biological Aging><Biological Markers><Biological Models><Birth><Body System><Brain><Brain Nervous System><Capuchin Monkey><Cebus><Cebus capucinus><Cebus imitator><Cellular Immune Function><Chronology><Complex><Costa Rica><Data><Data Collection><Data Set><Development><Diet Habits><Dietary Habits><Differences between sexes><Differs between sexes><Dimensions><Dorsum><Droughts><Elderly><Elderly Assessment><Encephalon><Environmental Factor><Environmental Risk Factor><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Female><Fruit><GI microbiome><Gait speed><Generations><Geriatric Assessment><Health><Heterogeneity><Human><In Situ><Increase lifespan><Individual><Individual Differences><Inflammation><Knowledge><Laboratories><Life><Life Cycle><Life Cycle Stages><Life Expectancy><Life Experience><Life Style><Lifestyle><Link><Literature><Lived experience><Lived experiences><Long-term prospective studies><Longitudinal Studies><Longitudinal Surveys><Measures><Methods><Mission><Model System><Modeling><Modern Man><Molecular><Monitor><NIH><National Institutes of Health><Onset of illness><Organ System><Outcome><Parturition><Pattern><Pedigree><Personal Satisfaction><Phase><Phenotype><Physical Function><Physical environment><Physiologic><Physiological><Population><Position><Positioning Attribute><Primates><Primates Mammals><Probabilistic Models><Probability Models><Process><Productivity><Proteome><Public Health><Rain><Research><Sampling><Sex Differences><Sexual differences><Social Behavior><Social Environment><Source><Statistical Models><Techniques><Temperature><Testing><United States National Institutes of Health><Variant><Variation><Wild Animals><accelerated aging><accelerated biological age><accelerated biological aging><access to health care><accessibility of health care><accessibility to health care><adulthood><advanced age><age acceleration><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><ages><aging biological marker><aging biomarker><aging marker><aging process><analog><analyzing longitudinal><behavior measurement><behavior observation><behavioral assessment><behavioral measure><behavioral measurement><behavioral observation><bio-markers><biologic><biologic marker><biological process of age><biomarker><boost longevity><capuchin><developmental><dietary fruit><digestive tract microbiome><disease onset><disorder onset><disparity in health><eating habit><elongating the lifespan><enhance longevity><enteric microbiome><environmental risk><epigenetically><experience><extend life span><extend lifespan><extend longevity><field based data><field learning><field study><field test><foster longevity><gastrointestinal microbiome><genetic pedigree><geriatric><geriatric screening><gut microbiome><gut-associated microbiome><hallmarks of aging><health assessment><health care access><health care availability><health care service access><health care service availability><health disparity><healthspan><healthy life span><immune function><improve lifespan><improve longevity><individual heterogeneity><individual variability><individual variation><innovate><innovation><innovative><insight><intergenerational><intestinal biome><intestinal microbiome><life course><life history><life span><lifespan><lifespan extension><long-term study><longitudinal analysis><longitudinal outcome studies><longitudinal research study><longitudinal, prospective study><male><member><model of animal><molecular domain><natural aging><non-human primate><nonhuman primate><normal aging><normative aging><novel><old age><pace of aging><pace of biological aging><pedigree structure><physical conditioning><physical health><pillars of aging><population based><prolong lifespan><prolong longevity><promote lifespan><promote longevity><rainfall><rate of aging><rate of biological aging><senior citizen><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social><social adversity><social climate><social context><social group><social relationships><sociobehavior><sociobehavioral><socioenvironment><socioenvironmental><socioenvironmental factor><speed of aging><speed of the aging><statistical linear mixed models><statistical linear models><support longevity><suprarenal gland><trait><translational study><well-being><wellbeing><white-faced capuchin><white-throated capuchin><♀><♂>

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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Benjamin Ross Freedman

BETH ISRAEL DEACONESS MEDICAL CENTER, BOSTON, MA

Exploratory lead · 16/100

Active award

$121,030

FY 2026

Project Title

Supplement Multifunctional Tough Adhesive Hydrogels to Recruit, Expand, and Deliver Tendon Cells During Aging and Injury

Grant Number:

3R00AG065495-05S1

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2020

End Date:

5/31/2027

Project Abstract

Project Summary/Abstract My laboratory studies structure-function mechanisms of tendon aging and injury and how they may be improved using biomaterials. My research training in bioengineering started by studying the role of healing and fatigue loading on multiscale tendon properties. I realized that...

Research Terms

View Full Project Details on NIH Reporter

Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Keith M Bellizzi

UNIVERSITY OF CONNECTICUT STORRS, STORRS-MANSFIELD, CT

Exploratory lead · 16/100

Active award

$80,500

FY 2026

Project Title

Exploring Cumulative Social Determinants Burden, Cancer, and Accelerated Aging: The Role of Physical Activity as a Moderator

Grant Number:

5R03CA297274-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

Project Summary/Abstract Despite progress in the fight against cancer, a disproportionate burden of cancer continues for many people disadvantaged by the social, political, and environmental systems in which they live. The same social determinants of health (non-medical factors) that contribute to d...

Research Terms

<21+ years old><Address><Adult><Adult Human><Adverse effects><Aging><All of Us Program><All of Us Research Program><All of Us Research Project><AoURP><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Cancer Burden><Cancer Survivor><Cancer Treatment><Cancers><Cell Aging><Cell Body><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Chronic Disease><Chronic Illness><Chronic stress><Clinical><Cohort Studies><Communities><Conditioning Therapy><DNA><DNA Damage><DNA Injury><DNA Methylation><Deoxyribonucleic Acid><Development><Disease><Disorder><Disparity population><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exercise><Exposure to><Future><Genes><Goals><Health><Health Disparities Research><Health Promotion><Health disparities related research><History><Individual><Inflammation><Intervention><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><NCMHD><NIH><NIMHD><National Cancer Burden><National Center on Minority Health and Health Disparities><National Institute of Minority Health and Health Disparities><National Institute on Minority Health and Health Disparities><National Institutes of Health><Oncology><Oncology Cancer><Participant><Pathway interactions><Patients><Persons><Physical Function><Physical activity><Politics><Recording of previous events><Replicative Senescence><Research><Risk><Risk Factors><Role><Salutogenesis><Sampling><Screening procedure><Social Well-Being><Stress><System><Telomere Shortening><Testing><United States National Institutes of Health><Upregulation><Vulnerable Populations><accelerated aging><accelerated biological age><accelerated biological aging><adulthood><age acceleration><age associated><age associated effects><age correlated><age dependent><age effect><age linked><age related><age related effects><age specific><aging associated><aging effect><aging prevention><aging process><aging related><anti aging><anti geronic><anti-cancer therapy><antiaging><behavior intervention><behavioral intervention><biological adaptation to stress><build resilience><build resiliency><cancer care><cancer diagnosis><cancer disparity><cancer health disparity><cancer survival><cancer therapy><cancer-directed therapy><cancer-related health disparity><case control><case-controlled><chronic disorder><cohort><cohort research study><cohort survey><develop resilience><develop resiliency><developmental><disadvantaged group><disadvantaged individual><disadvantaged people><disadvantaged population><disadvantaged subgroup><disparities across groups><disparity across subgroups><disparity among groups><disparity among subgroups><disparity between groups><disparity between subgroups><disparity in cancer><enhance resilience><enhance resiliency><epigenetically><ethnic diversity><ethnically diverse><facilitate resilience><fighting><frailty><group disparity><group inequality><group inequity><hallmarks of aging><health disparities science><health equity><histories><impact of age><improve resilience><improve resiliency><improved><increase resilience><increase resiliency><indexing><inequalities among populations><inequalities between populations><inequalities in populations><inequality across populations><inequality among groups><inequality between groups><inequality in groups><inequities among populations><inequities between populations><inequities in populations><inequity across groups><inequity across populations><inequity between groups><inequity in groups><influence of age><malignancy><malleable risk><modifiable behavior><modifiable risk><neoplasm/cancer><pathway><pillars of aging><population inequality><population inequity><premature><prematurity><prevent age related><prevent aging><promote resilience><promote resiliency><promoting health><racial diversity><racially diverse><reactioncrisis><replicative aging><resilience development><resilience factor><resiliency factor><screening tools><social determinants><social disadvantage><social disparities><social factors><social health determinants><social inequality><social role><social wellbeing><sociodeterminant><stem cell depletion><stem cell exhaustion><stem cell fatigue><stress response><stressreaction><structural determinants><structural factors><subgroup disparity><suppress aging><telomere><telomere attrition><unequal group><unequal population><unhealthy lifestyle><virtual><vulnerable group><vulnerable individual><vulnerable people>

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Tamara A Baker

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 16/100

Active award

$49,971

FY 2026

Project Title

Elevating efforts to recruit and retain HBCU scholars in the field of aging

Grant Number:

5R13AG085949-03

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

11/7/2023

End Date:

10/31/2028

Project Abstract

Population aging suggests the need for an increased workforce of community advocates, academic scholars, health care providers, and other professionals with training in gerontology/geriatric medicine or a related discipline. Established in the early 19th century, Historically Black Colleges and Univ...

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Darlingtina Esiaka

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 16/100

Active award

$49,971

FY 2026

Project Title

Elevating efforts to recruit and retain HBCU scholars in the field of aging

Grant Number:

5R13AG085949-03

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

11/7/2023

End Date:

10/31/2028

Project Abstract

Population aging suggests the need for an increased workforce of community advocates, academic scholars, health care providers, and other professionals with training in gerontology/geriatric medicine or a related discipline. Established in the early 19th century, Historically Black Colleges and Univ...

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Candidus Nwakasi

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 16/100

Active award

$49,971

FY 2026

Project Title

Elevating efforts to recruit and retain HBCU scholars in the field of aging

Grant Number:

5R13AG085949-03

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

11/7/2023

End Date:

10/31/2028

Project Abstract

Population aging suggests the need for an increased workforce of community advocates, academic scholars, health care providers, and other professionals with training in gerontology/geriatric medicine or a related discipline. Established in the early 19th century, Historically Black Colleges and Univ...

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TERRY L. SHEPPARD

KEYSTONE SYMPOSIA, SILVERTHORNE, CO

Exploratory lead · 16/100

Active award

$19,600

FY 2026

Project Title

Aging: Immune Function and Organ Health

Grant Number:

1R13AG099774-01

Activity Code:

R13

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2027

Project Abstract

Abstract Support is requested for a Keystone Symposia conference entitled “Aging: Immune Function and Organ Health,” organized by Drs. Anne Brunet, Eric M. Verdin, Manuel Serrano and P. Eline Slagboom, with scientific programming input from Keystone Symposia. The meeting will take place March 22–25,...

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Katrin F. Chua

VETERANS ADMIN PALO ALTO HEALTH CARE SYS, PALO ALTO, CA

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Elucidating functions of mammalian SIRT7 deacetylase in aging and disease

Grant Number:

5I01BX000286-14

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2009

End Date:

12/31/2028

Project Abstract

Project Summary/Abstract Background and Innovation: The chromatin regulatory enzyme SIRT7 is implicated in many cellular processes associated with aging such as genomic instability, DNA damage, and cellular senescence. SIRT7- deficient mice exhibit shortened lifespan and many signs of premature agin...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Acceleration><Acetylation><Adipocytes><Adipose Cell><Adipose tissue><Adult-Onset Diabetes Mellitus><Affect><Age><Age related pathologies><Aged 65 and Over><Aging><American><Autoregulation><Biochemical><Biologic Models><Biological><Biological Models><Biology><Biology of Aging><Blood Precursor Cell><Body System><Body Tissues><Brown Adipose Tissue><Brown Fat><Cancers><Cardiac Diseases><Cardiac Disorders><Cell Aging><Cell Body><Cell Function><Cell Physiology><Cell Process><Cell Senescence><Cell model><Cells><Cellular Aging><Cellular Function><Cellular Physiology><Cellular Process><Cellular Senescence><Cellular model><Chromatin><Chronic><Chronic Disease><Chronic Illness><Community Surveys><Complement><Complement Proteins><Complex><Coupled><DNA><DNA Damage><DNA Injury><DNA Molecular Biology><Deacetylase><Deacetylation><Deoxyribonucleic Acid><Disease><Disease Pathway><Disorder><Dysfunction><Dyslipidemias><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exhibits><Family><Fat Cells><Fatty Liver><Fatty Tissue><Functional disorder><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Generations><Genes><Genome><Genome Instability><Genomic Instability><Genomic approach><Genomics><Glucose Intolerance><Goals><Health><Health Care><Heart Diseases><Heat Production><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Hepatic Disorder><Hibernating Gland><Histones><Homeostasis><Incidence><Increase lifespan><Individual><Inflammatory><Intermediary Metabolism><KO mice><Ketosis-Resistant Diabetes Mellitus><Knock-out Mice><Knockout Mice><Learning><Link><Lipocytes><Liver Steatosis><Liver diseases><Malignant Neoplasms><Malignant Tumor><Mammalia><Mammals><Mature Lipocyte><Mature fat cell><Maturity-Onset Diabetes Mellitus><Medical><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Pathway><Metabolic Processes><Metabolic dysfunction><Metabolism><Methylation><Mice><Mice Mammals><Model System><Modeling><Molecular><Molecular Biology><Morbidity><Murine><Mus><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nuclear><Null Mouse><Obese Mice><Obesity><Organ System><Overnutrition><Pathology><Pathway interactions><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Play><Population><Premature Aging><Premature aging syndrome><Process><Replicative Senescence><Reporting><Research><Risk Factors><Role><Silent Mating Type Information Regulator 2-like Proteins><Sir2-like Proteins><Sirtuins><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Subcellular Process><System><T2 DM><T2D><T2DM><Testing><Therapeutic><Thermogenesis><Thesaurismosis><Tissues><Translating><Translations><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Veterans><Work><above age 65><adipose><adiposity><adult onset diabetes><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age associated alterations><age associated changes><age associated disease><age associated disorder><age associated impairment><age associated pathologies><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent disease><age dependent disorder><age dependent impairment><age dependent pathologies><age induced alterations><age induced changes><age induced pathologies><age linked><age of 65 years onward><age related><age related alterations><age related changes><age related human disease><age related pathways><age specific><age specific alterations><age specific changes><age-related disease><age-related disorder><age-related impairment><aged 65 and greater><aged 65+><aged ≥65><ages><aging associated><aging associated alterations><aging associated changes><aging associated disease><aging associated disorders><aging associated mechanism><aging associated pathologies><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging dependent pathologies><aging induced alterations><aging induced changes><aging induced pathologies><aging mechanism><aging nutrition><aging pathologies><aging pathway><aging related><aging related alterations><aging related changes><aging related disease><aging related disorders><aging related mechanism><aging related pathologies><aging related pathways><aging specific alterations><aging specific changes><alterations with age><biologic><biological mechanism of age><biological pathways of age><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><boost longevity><changes with age><chronic disorder><complementation><conflict resolution><corpulence><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><elongating the lifespan><energy balance><enhance longevity><epigenetically><epigenomics><extend life span><extend lifespan><extend longevity><foster longevity><genomic effort><genomic strategy><heart disorder><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><hepatic disease><hepatic steatosis><hepatopathy><hepatosteatosis><histone modification><human disease><human old age (65+)><improve lifespan><improve longevity><improved><in vivo><induced Cre><inducible Cre><innovate><innovation><innovative><insight><ketosis resistant diabetes><life span><lifespan><lifespan extension><lipid disorder><liver disorder><loss of function><malignancy><maturity onset diabetes><mechanism regulating aging><mechanisms involved in aging><metabolic phenotype><metabolism disorder><metabotype><military veteran><mitochondrial dysfunction><mouse model><murine model><neoplasm/cancer><novel><ob/ob mouse><over 65 years><overexpress><overexpression><pathophysiology><pathway><pathway involved in aging><pharmacologic><prevent><preventing><programs><prolong lifespan><prolong longevity><promote lifespan><promote longevity><replicative aging><social role><subcutaneous><subdermal><support longevity><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic development><transcriptomics><translation><tumor><type 2 DM><type II DM><type two diabetes><veteran population><virtual><white adipose tissue><yellow adipose tissue><≥65 years>

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Milos Marinkovic

RLR VA MEDICAL CENTER, INDIANAPOLIS, IN

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Role of Cyr61/CCN1 in Mesenchymal Stem Cell Niche and Aging Bone

Grant Number:

5IK2BX005694-05

Activity Code:

IK2

Mechanism:

Other

Agency:

VA

Start Date:

1/1/2022

End Date:

12/31/2026

Project Abstract

Aging-related skeletal degeneration is associated with changes in bone microarchitecture, loss of bone mineral density (BMD), increased susceptibility to fracture, and delayed bone healing. A key factor in these degenerative changes is the formation of osteoprogenitors (i.e. mesenchymal stem cells [...

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Maureen Katheleen O'Connor

EDITH NOURSE ROGERS MEMORIAL VETERANS HOSPITAL, BEDFORD, MA

Exploratory lead · 16/100

Active award

$0

FY 2026

Project Title

Aging Well through Interactions and Scientific Education - Action Plan (AgeWISE-AP)

Grant Number:

5I01RX004828-03

Activity Code:

I01

Mechanism:

Non-SBIR/STTR

Agency:

VA

Start Date:

10/1/2023

End Date:

9/30/2027

Project Abstract

The overall goal of this proposal is to conduct a fully powered randomized controlled trial of a multi-component intervention designed to provide education about brain aging, improve feelings of control over brain aging, and deliver practical assistance with creation of an executable action plan (Ag...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Active Follow-up><Affective><Age><Aged 65 and Over><Aging><Amentia><Anxiety><Area><Attitude><Biological Markers><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Caring><Clinical Services><Coffee><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Control Groups><Dementia><Diet><Disturbance in cognition><Education><Educational aspects><Educational process of instructing><Emotional well being><Encephalon><Encephalon Diseases><Exercise><Feeling><Feels well><Foundations><Friends><Funding><General Population><General Public><Generalized Growth><Genetic><Goals><Growth><Health Services><Health system><Healthy diet><Home><Housing><Impaired cognition><Individual><Integrated Health Care Systems><Intervention><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Learning><Life><Life Style Modification><Literature><Loneliness><Meaning and purpose><Memory><Mental Depression><Methods><Normal mental condition><Normal mental state><Normal psyche><Participant><Patient Self-Report><Perception><Pilot Projects><Psychological Well Being><QOL><Quality of life><Randomized><Randomized, Controlled Trials><Recommendation><Research><Risk><Risk Factors><Role><Self Efficacy><Self-Report><Sense of well-being><Services><Sight><Sleep><Social Conditions><Socialization><Societal Conditions><Strategic Planning><Teaching><Techniques><Thinking><Tissue Growth><Veterans><Vision><Well in self><above age 65><active followup><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated effects><age effect><age of 65 years onward><age related cognitive change><age related effects><aged 65 and greater><aged 65+><aged brain><aged ≥65><ages><aging brain><aging effect><balanced diet><behavior change><bio-markers><biologic marker><biomarker><brain health><cognitive assessment><cognitive change><cognitive dysfunction><cognitive loss><cognitive testing><compare to control><comparison control><dementia risk><depression><diets><emotional wellbeing><emotional wellness><evidence base><feelings><follow up><follow-up><followed up><followup><good diet><health plan><health plans><healthy lifestyle><homes><human old age (65+)><impact of age><improved><influence of age><innovate><innovation><innovative><integrated health system><integrated system of care><intervention design><late in life><late life><life style intervention><life-style factor><lifestyle factors><lifestyle intervention><lifestyle modification><lonely><mental well-being><mental wellbeing><mental wellness><military veteran><multi-component intervention><multi-faceted intervention><multi-modal intervention><multicomponent intervention><multifaceted intervention><multimodal intervention><neural imaging><neuro-imaging><neuroimaging><neurological imaging><ontogeny><over 65 years><pilot study><programs><psychologic><psychological><psychological wellbeing><psychological wellness><randomisation><randomization><randomized control trial><randomly assigned><risk factor for dementia><risk for dementia><self wellness><sense of wellbeing><skills><social><social role><stress reduction><therapy design><thoughts><treatment design><veteran population><visual function><whole health><whole person health><≥65 years>

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