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Search Results

Found 88 principal investigators from 164 displayed projects for "R37" (2021–2026)

Opportunity Digest

Heuristic scoring to help trainees and job seekers prioritize which labs to inspect first.

0

High-opportunity leads

17

Likely hiring signals

4

Training-friendly awards

24

Average opportunity score

Prioritize records with strong opportunity signals, then validate fit using abstracts, institution pages, and lab websites.

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Rama Rao Amara

EMORY UNIVERSITY, ATLANTA, GA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$907,904
FY 2026

Project Title

Targeting PD-1 Pathway for Functional Cure of AIDS

Grant Number:

5R01AI112787-13

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2014

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

This proposal aims to develop an effective therapy to achieve HIV remission by improving the magnitude, breadth, and function of anti-viral CD8 T cells and reducing viral reservoirs using the SIV/macaque model. Dysfunctional anti-HIV immunity and the persistence of viral reservoirs represent two maj...

Research Terms

<AIDS><AIDS Virus><AIDS/HIV><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Address><Adenoviridae><Adenoviruses><Advanced HIV><Animals><Antigenic Determinants><Antigens><Binding><Binding Determinants><Blood><Blood Reticuloendothelial System><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Chimp><Chimpanzee><Chronic><Class I Genes><Co-Stimulator><Combination Vaccines><Combined Modality Therapy><Combined Vaccines><Costimulator><DNA/MVA vaccine><Data><Detection><Disease remission><Effector Cell><Epidermal Thymocyte Activating Factor><Epitopes><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Frequencies><Germinal Center><Goals><Grant><Granzyme><HIV><HIV cure><HIV functional cure><HIV-1 cure><HIV-1 functional cure><HIV/AIDS><HIV/AIDS cure><Haplotypes><Heterogeneity><Human><Human Immunodeficiency Viruses><IL-2><IL2 Protein><Immune mediated therapy><Immunity><Immunologically Directed Therapy><Immunotherapy><Infection><Interleukin 2><Interleukin 2 Precursor><Interleukin II><Interleukin-2><Interleukine 2><Interleukine 2 Precursor><Interleukine II><Interruption><Investments><LAV-HTLV-III><LCM Viruses><LCMV><LYT3><Laboratories><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphadenopathy-Associated Virus><Lymphatic nodes><Lymphocyte Mitogenic Factor><Lymphocytic choriomeningitis virus><M mulatta><M. mulatta><MHC Class I><MHC Class I Genes><Macaca><Macaca mulatta><Macaca rhesus><Macaque><Mice><Mice Mammals><Mitogenic Factor><Modeling><Modern Man><Molecular Interaction><Monitor><Multimodal Therapy><Multimodal Treatment><Murine><Mus><PD 1><PD-1><PD-1 antibody><PD-1 blockade><PD-1 checkpoint pathway><PD-1 pathway><PD-1 signaling pathway><PD1><PD1 antibody><PD1 blockade><PD1 checkpoint pathway><PD1 pathway><PD1 signaling pathway><Pathway interactions><RNA Seq><RNA sequencing><RNAseq><Remission><Rhesus Macaque><Rhesus Monkey><SIV><Safety><Severe HIV Disease><Simian Immunodeficiency Viruses><Sorting><Structure of germinal center of lymph node><Subcellular Process><T cell growth factor><T cell response><T-Cell Growth Factor><T-Cell Stimulating Factor><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T4 Cells><T4 Lymphocytes><T8 Cells><T8 Lymphocytes><Testing><Therapeutic><Thymocyte Stimulating Factor><Treatment Efficacy><VAC-TX><Vaccinated><Vaccination><Vaccine Therapy><Vaccines><Viral><Viral reservoir><Viremia><Virus reservoir><Virus-HIV><Work><aPD-1><aPD1><anti programmed cell death 1><anti programmed cell death protein 1 checkpoint pathway><anti programmed cell death protein 1 pathway><anti programmed cell death protein 1 signaling pathway><anti-PD-1><anti-PD-1 Ab><anti-PD-1 antibodies><anti-PD-1 blockade><anti-PD-1 monoclonal antibodies><anti-PD1><anti-PD1 Ab><anti-PD1 antibodies><anti-PD1 blockade><anti-PD1 monoclonal antibodies><anti-programmed cell death protein 1><anti-programmed cell death protein 1 antibodies><anti-programmed death-1 antibody><antiPD-1><antiretroviral therapy><antiretroviral treatment><combination therapy><combined modality treatment><combined treatment><cytokine based immunotherapy><cytokine based therapy><cytokine immunotherapy><cytokine therapy><cytokine treatment><effective therapy><effective treatment><exhaust><exhaustion><flow cytophotometry><human immunodeficiency virus cure><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunogen><improved><intervention efficacy><lymph gland><lymph nodes><lymphnodes><lymphocyte pore-forming protein><multi-modal therapy><multi-modal treatment><non vaccinated><not vaccinated><pathway><perforin><programmed cell death 1><programmed cell death protein 1><programmed death 1><programs><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><sle2><success><synergism><systemic lupus erythematosus susceptibility 2><therapeutic efficacy><therapeutic outcome><therapeutic vaccination><therapeutic vaccine><therapy efficacy><therapy outcome><thymus derived lymphocyte><transcriptome sequencing><transcriptomic sequencing><treatment vaccines><unvaccinated><vaccine for the treatment><vaccine for treatment><viraemia><viral rebound><viral sepsis><virus rebound><virusemia><αPD-1><αPD1>
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Stefan M. PULST

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$930,250
FY 2025

Project Title

Ataxin-2 complex proteins in neurodegeneration.

Grant Number:

5R35NS127253-04

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2022

End Date:

4/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract This R35 proposal builds on experiments supported by a Javits R37 and a U01 CREATE Bio award and the longstanding success of the principal investigator’s group leading from mechanistic discoveries in spinocerebellar ataxias and translation to novel treatments, one of which i...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Animal Model><Animal Models and Related Studies><Animals><Apoptotic><Ataxia><Ataxy><Autophagocytosis><Award><Behavioral><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cerebellar degeneration><Cessation of life><Chemicals><Complex><Coordination Impairment><Cytoplasm><Death><Degenerative Neurologic Disorders><Deterioration><Dimensions><Disease><Disorder><Dominantly-Inherited Spinocerebellar Ataxias><Dyssynergia><Environment><Foundations><Funding><Gene Targeting><Genes><Grant><Heat shock proteins><Hereditary><Human><In Vitro><Inherited><Intracellular Communication and Signaling><Laboratories><Mediating><Modeling><Modern Man><Morphology><Motor Cell><Motor Neuron Disease><Motor Neurons><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Nutrient><Pathogenicity><Phase><Physiologic><Physiological><Poly Q><Principal Investigator><Proteins><Proteomics><Purkinje Cells><Purkinje's Corpuscles><RNA Transport><RNA metabolism><RNA-Binding Proteins><Regulation><Reproducibility><Research><Resource Sharing><Ribonucleic Acid Transport><Role><SCA2 protein><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Small RNA><Spinal><Spinocerebellar Ataxias><Spinocerebellar Atrophies><Stress><Techniques><Time><Translations><adulthood><ataxin-2><autophagy><biological signal transduction><cerebellar Purkinje cell><cerebellum degeneration><degenerative diseases of motor and sensory neurons><degenerative disorder of motor neurons><degenerative neurological diseases><diversity and inclusion><diversity and inclusivity><dosage><experiment><experimental research><experimental study><experiments><genome scale><genome-wide><genomewide><human model><in vivo><innovate><innovation><innovative><insight><model of animal><model of human><motoneuron><muscle strength><mutant><nerve cell death><nerve cell loss><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><novel><polyQ><polyglutamine><protein complex><protein function><response><small molecule><social role><spinocerebellar ataxia type 2 gene product><stress protein><success><therapeutic target><tool><transcriptomics><translation>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Krishna P Reddy

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$809,775
FY 2024

Project Title

Novel Methods to Inform HIV/TB Clinical Trial Development

Grant Number:

5R01AI093269-14

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2011

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

During the first 3.5 years of this R37 cycle, Novel Methods to Inform HIV/TB Clinical Trial Development has used decision science methodologies, focusing on value of information, and demonstrated outstanding productivity, methods expansion, trainee development, policy impact, and international co...

Research Terms

<AIDS><Accounting><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immunodeficiency Syndrome><Antibodies><Area><Cause of Death><Clinical Trials><Clinical Trials Design><Collaborations><Costs and Benefits><Development><Evaluation><HIV/Mtb><HIV/TB><HIV/mycobacterium tuberculosis><HIV/tuberculosis><Instruction><International><M. tuberculosis/HIV><Mediating><Methodology><Methods><Modeling><Monte Carlo Method><Monte Carlo algorithm><Monte Carlo calculation><Monte Carlo procedure><Monte Carlo simulation><Policies><Prevention><Productivity><Reporting><Research Resources><Resources><Sampling><Science><South Africa><TB diagnostics><Vaccines><antiretroviral therapy><antiretroviral treatment><cost effectiveness><design><designing><developmental><diagnostic approach><diagnostic strategy><immunization strategy><information framework><low income country><novel><prevent><preventing><treatment strategy><tuberculosis diagnostics><vaccination strategy>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

EVE E MARDER

BRANDEIS UNIVERSITY, WALTHAM, MA

Good lead · 50/100
Likely hiring
Large award
$1,047,293
FY 2024

Project Title

Neuromodulation and Robustness of Neurons and Networks

Grant Number:

5R35NS097343-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2016

End Date:

8/31/2025

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.

Project Abstract

Project Summary/Abstract This is a request to consolidate three ongoing NINDS-funded proposals that deal with neuromodulation (R37 NS 17813), temperature compensation (R01 NS 81012), and computational models of homeostatic regulation of intrinsic excitability (Project #4 of P01 NS07949). Together t...

Research Terms

<Address><Animals><Behavior><Biological><Brain><Brain Nervous System><Compensation><Computer Models><Computerized Models><Crustacea><Crustacean><Encephalon><Funding><Future><Ganglia><Goals><Human><Individual><Invertebrata><Invertebrates><Ion Channel><Ionic Channels><Measures><Membrane Channels><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Modeling><Modern Man><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neural Ganglion><Neurocyte><Neurologic Body System><Neurologic Organ System><Neuromodulator Receptors><Neurons><Receptor Protein><Regulation><Surface Proteins><Synapses><Synaptic><Temperature><Time><Work><biologic><computational modeling><computational models><computer based models><computerized modeling><experiment><experimental research><experimental study><experiments><flexibility><flexible><neural control><neural regulation><neuromodulation><neuromodulatory><neuronal><neuroregulation><receptor><response><synapse>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Frederick W. Alt

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 48/100
Above-average budget
Very recent
Active award
$637,200
FY 2026

Project Title

Mechanisms that Regulate Antibody Class Switch Recombination and Somatic Hypermutation

Grant Number:

5R37AI077595-18

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2008

End Date:

3/31/2029

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract of Research Plans for the Extension Period The first two specific aims of this R37 grant were to test our hypothesis that cohesin-mediated loop extrusion plays a key role in lgH class switch recombination (CSR) and lg variable region exon somatic hypermutation (SHM). A third...

Research Terms

<Address><Alleles><Allelism Test><Allelomorphs><Antibodies><Antigens><Assay><Autoantigens><Autologous Antigens><B blood cells><B cell><B cell repertoire><B cells><B-Cell Activation><B-Cells><B-Lymphocytes><B-cell><Binding><Bioassay><Biologic Models><Biological Assay><Biological Models><Blastosphere><Cell Body><Cell Cycle><Cell Division Cycle><Cell Line><Cell Lineage><CellLine><Cells><Chromatin><Chromatin Loop><Chromatin Loop Domains><Chronic><Class Switching><Class Switchings><Comment><Commentary><Complementation Test><Complex><Constant Region><DNA Loop><DSS colitis><DSS model><DSS mouse model><DSS-induced acute colitis><DSS-induced colitis><Development><Disease><Disorder><Downstream Enhancer><ES cell><Editorial Comment><Elements><Engineering><Enhancers><Exons><First Gap Phase><Frequencies><G1 Phase><G1 period><GRO-seq><GROseq><Gap Phase 1><Gene Transcription><Generations><Genetic Complementation Test><Genetic Transcription><Genomic Segment><Germ Lines><Germinal Center><Goals><Grant><Guide RNA><Human><Ig Constant Region><Ig Somatic Hypermutation><Image><Immunoglobulin Class Switching><Immunoglobulin Class Switchings><Immunoglobulin Constant Region><Immunoglobulin Isotype-Switch Recombination><Immunoglobulin Somatic Hypermutation><Immunoglobulin Switch Recombination><Immunoglobulin V(D)J Rearrangement><Instruction><Intestinal><Intestines><Isotype Switching><Isotype Switchings><Knock-in><Label><Location><Maps><Mediating><Mice><Mice Mammals><Model System><Modeling><Modern Man><Molecular Interaction><Murine><Mus><PET><PET Scan><PET imaging><PETSCAN><PETT><Pattern><Peyer's Patches><Physiologic><Physiological><Physiology><Play><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Predisposition><Preimplantation Embryo><Probability><Productivity><Progress Reports><Publications><Published Comment><RNA Expression><Rad.-PET><Recurrence><Recurrent><Regulation><Repetitive Element><Repetitive Regions><Repetitive Sequence><Reporting><Research><Role><Scientific Publication><Self-Antigens><Site><Strains Cell Lines><Structure of germinal center of lymph node><Study models><Susceptibility><Switch Recombination><System><Testing><Textbooks><Trans Test><Transcription><V(D)J Rearrangement><V(D)J Recombination><VDJ rearrangement><VDJ recombination><Viewpoint><Work><activated B cells><blastocyst><blastula><bowel><cohesin><colitis-induced dysbiosis><complementation analysis><complementation approach><cultured cell line><developmental><dextran sulfate sodium colitis><dextran sulfate sodium induced colitis><dextran sulfate sodium model><dextran sulfate sodium mouse model><dietary><embryo derived stem cell><embryonal stem cells><embryonic progenitor><embryonic stem cell><gRNA><genome segment><genomic region><global run on sequencing><global run on transcription sequencing><imaging><immunogen><in vivo><in vivo Model><insight><knockin><microbial><microbiome><microbiota composition><mouse model><murine model><new technology><news><novel technologies><pandemic><pandemic disease><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-implantation embryo><protein complex><repair><repaired><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><somatic hypermutation><stem cell of embryonic origin>
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Edward T. Ryan

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 48/100
Above-average budget
Very recent
Active award
$633,392
FY 2026

Project Title

O-Specific Polysaccharide Responses and Cholera

Grant Number:

5R37AI106878-12

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/7/2013

End Date:

3/31/2030

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Cholera is a severe dehydrating illness of humans. It is endemic in over 50 countries and causes 3 to 5 million cases a year, resulting in approximately 100,000 deaths. Currently available cholera vaccines are poorly immunogenic in children under the age of 5 years, and often do not induce robust lo...

Research Terms

<0-11 years old><19S Gamma Globulin><21+ years old><5 year old><5 years of age><7S Gamma Globulin><Ab-mediated immunity><Ab-mediated protection><Address><Adult><Adult Human><Affect><Affinity><Animals><Antibodies><Antibody immunity><Antibody protection><Antibody-mediated protection><Antigens><B-cell receptor repertoire sequencing><B-cell receptor sequencing><BCR repertoire sequencing><BCR seq><BCR sequencing><BCRseq><Bacterial O Antigen><Bangladesh><Body Tissues><Cell Body><Cells><Cessation of life><Child><Child Youth><Children (0-21)><Cholera><Cholera Vaccine><Clinical Treatment Moab><Country><Data><Death><Dehydration><Development><ELISPOT><Endoscopic Biopsy><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Gene Expression><Gene Transcription><Genetic Transcription><Genomics><Goals><Household><Human><IgA><IgG><IgM><Immune><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunoglobulin A><Immunoglobulin G><Immunoglobulin M><Immunologic><Immunological><Immunologically><Immunologics><Immunology><Infection with V cholerae><Infection with V. cholerae><Infection with Vibrio cholerae><Instruction><International><Intestinal><Intestines><Knowledge><MHC Receptor><Major Histocompatibility Complex Receptor><Mediating><Methods><Microbe><Microbiology><Modeling><Modern Man><Monoclonal Antibodies><Motility><Mucins><Mucosa><Mucosal Tissue><Mucous Membrane><Mucus Glycoprotein><O Antigens><O-Specific Polysaccharides><Oral><Organoids><Patients><Peer Review><Penetration><Peripheral><Population><Position><Positioning Attribute><Process><Productivity><Proteomics><Protocol><Protocols documentation><Publications><RNA Expression><Reagent><Research><Research Resources><Resources><Sampling><Scientific Publication><Serology><Single-Nucleus Sequencing><Surface><System><T-Cell Antigen Receptors><T-Cell Receptor><Tissue Sample><Tissues><Toxin><Transcription><V cholerae><V cholerae O1><V cholerae Serogroup O1><V cholerae infection><V. cholerae><V. cholerae O1><V. cholerae Serogroup O1><V. cholerae infection><Vaccines><Vibrio cholerae><Vibrio cholerae O1><Vibrio cholerae Serogroup O1><Vibrio cholerae infection><Vibrio comma><Work><adulthood><age 5><age 5 years><antibody-mediated immunity><biological sex><body water dehydration><bowel><cholera infection><complement deficiency><defined contribution><developmental><diarrheal disease><diarrheal illness><enzyme linked immunospot assay><experience><five year old><five years of age><flow cytophotometry><holotoxins><host response><human subject><immune system response><immunization strategy><immunogen><immunogenic><immunoresponse><improved><infected with cholera><infection with cholera><international center><intestinal epithelium><kids><long-term memory><mAbs><monoclonal Abs><mouse model><murine model><next generation><pathogen><peripheral blood><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><programs><response><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><sound><success><vaccination strategy><vaccine strategy><youngster>
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Jessica Scott

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Good lead · 48/100
Above-average budget
Very recent
Active award
$619,794
FY 2026

Project Title

A Randomized Trial to Minimize Non-Response to Aerobic Training in Operable Breast Cancer

Grant Number:

5R37CA248665-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Cardiovascular disease (CVD) is the primary cause of late mortality (death ≥5 yrs from diagnosis) in early breast cancer (EBC). Effective treatment strategies that improve function across multiple systems are needed in order to reduce CVD in EBC. Aerobic exercise therapy (AT...

Research Terms

<Active Follow-up><Address><Adjuvant Therapy><Adverse Experience><Adverse event><Aerobic Activity><Aerobic Exercise><Aerobic Training><Aerobic fitness><After Care><After-Treatment><Aftercare><Age><Biological><Blood Vessels><Breast><Breast Cancer><Breast Cancer Patient><Breast Cancer survivor><Breast Cancer therapy><Breast Tumor Patient><CTCAE><Cancer Cause><Cancer Etiology><Cancer Treatment><Cancers><Cardiac Output><Cardiac artery><Cardiopulmonary><Cardiovascular Diseases><Cessation of life><Characteristics><Classification><Clinical><Common Terminology Criteria for Adverse Events><Common Toxicity Criteria><Coronary artery><Data><Death><Diagnosis><Dose><Early treatment><Evaluation><Event><Evidence based practice guidelines><Exercise><Exercise Therapy><Frequencies><Funding><Heart><Heart artery><History><Home><Interruption><Intervention><Investigation><Knowledge><Length><Life Style><Lifestyle><Long-Term Effects><Lung><Lung Respiratory System><Malignant Breast Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Masks><Measurement><Measures><Modification><Monitor><Morbidity><Muscle><Muscle Tissue><O element><O2 element><Oncology><Oncology Cancer><Outcome><Oxygen><Oxygen Consumption><Parents><Participant><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patient Self-Report><Patients><Peripheral><Phase><Phase 2/3 trial><Phase II/III Trial><Physiologic><Physiological><Policies><Population><QOL><Qualifying><Quality of life><Random Allocation><Random Selection><Randomization trial><Randomized, Controlled Trials><Recording of previous events><Regimen><Risk><Safety><Sampling Studies><Self-Report><Skeletal Muscle><Stretching><Structure><Survivors><Symptom Burden><System><Systematics><Testing><Therapeutic exercise><Therapy trial><Time><Venous><Voluntary Muscle><Woman><Work><active followup><adjuvant treatment><ages><anti-cancer therapy><arm><attentional control><biologic><cancer care><cancer therapy><cancer-directed therapy><cardiorespiratory fitness><cardiorespiratory health><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><chemotherapy><clinical care><clinical relevance><clinically relevant><cytotoxic><early therapy><effective therapy><effective treatment><efficacy testing><evidence based guidelines><evidence based recommendations><exercise physiologist><exercise program><exercise treatment><fitness program><follow up><follow-up><followed up><followup><functional improvement><heart output><histories><homes><implementation outcomes><improve function><improved><improved functional outcomes><individuals with breast cancer><instrument><inter-individual variability><inter-individual variation><irradiation-induced injury><malignancy><malignant breast tumor><mortality><muscular><neoplasm/cancer><novel><parent><patients with breast cancer><person with breast cancer><post intervention><post treatment><primary end point><primary endpoint><programs><radiation-induced injury><randomized control trial><randomized trial><response><response to therapy><response to treatment><survivorship><tele-exercise><therapeutic response><therapy adherence><therapy compliance><therapy response><treadmill><treated with exercise><treatment response><treatment responsiveness><treatment strategy><trial design><vascular><virtual>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Diego A Pizzagalli

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Good lead · 48/100
Above-average budget
Very recent
Active award
$603,125
FY 2026

Project Title

Neuroimaging Studies of Reward Processing in Depression

Grant Number:

7R37MH068376-21

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/7/2025

End Date:

2/28/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Major Depressive Disorder (MDD) remains a major public health problem with poorly understood etiology and pathophysiology. Impairment in reward processing and anhedonia are core features of MDD. Findings during the prior award period have shown that MDD and anhedonic phenotypes are characterized ...

Research Terms

<Active Follow-up><Anhedonia><Animals><Anterior><Award><Behavioral><Binding><Brain region><Causality><Chromosomal, Gene, or Protein Abnormality><Common Rat Strains><Corpus Striatum><Corpus striatum structure><Cytogenetic or Molecular Genetic Abnormality><Depressed mood><Disease><Disease remission><Disorder><Dysfunction><Emotional Depression><Etiology><Frequencies><Functional Imaging><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Genetic Abnormality><Goals><History><Hormonal><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><Individual><Inflammatory><KO mice><Knock-out Mice><Knockout Mice><Learning><Life><Major Depressive Disorder><Maps><Mental Depression><Messenger RNA><Molecular Abnormality><Molecular Interaction><Noci-R><Null Mouse><OFQ receptor><ORL1 receptor><PBMC><PET><PET Scan><PET imaging><PETSCAN><PETT><Participant><Pathway interactions><Peptide Receptor><Peptides><Peripheral Blood Mononuclear Cell><Phenotype><Physiologic Imaging><Physiopathology><Play><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Preclinical data><Prefrontal Cortex><Prevention><Psychological reinforcement><Public Health><Rad.-PET><Rat><Rats Mammals><Rattus><Recording of previous events><Regulation><Reinforcement><Remission><Reporting><Research><Rewards><Rodent><Rodentia><Rodents Mammals><Role><Stress><Stressful Event><Striate Body><Striatum><Structural defect><Structural malformation><Symptoms><System><Tracer><Transcriptional Control><Transcriptional Regulation><Upregulation><Ventral Tegmental Area><Work><active followup><antagonism><antagonist><anti-depressant agent><anti-depressant drugs><anti-depressants><anti-depressive agents><biological adaptation to stress><causation><cingulate cortex><clinical depression><cytokine><depressed><depression><depression symptom><depressive><depressive behavior><depressive symptoms><design><designing><disease causation><fMRI><follow up><follow up assessment><follow-up><followed up><followup><followup assessment><histories><improved><inflammation marker><inflammatory marker><innovate><innovation><innovative><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><mRNA><major depression><major depression disorder><molecular aberrations><molecular imaging><molecule imaging><neural><neural imaging><neuro-imaging><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological imaging><nociceptin><nociceptin opioid peptide receptor><nociceptin opioid receptor><nociceptin receptor><novel><opioid-receptor-like 1 protein><orphanin FQ><orphanin FQ receptor><pathophysiology><pathway><physiological imaging><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><pre-clinical study><preclinical><preclinical findings><preclinical information><preclinical study><prospective><reactioncrisis><response><reward processing><sadness><social defeat><social role><stress response><stressreaction><stressful experience><stressful life event><stressful life experience><striatal><structural abnormalities><structural anomalies><trait><ventral tegmentum>
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PEI ZHONG

DUKE UNIVERSITY, DURHAM, NC

Good lead · 46/100
Likely hiring
Solid budget
Active award
$493,936
FY 2025

Project Title

Innovations in Shock Wave Lithotripsy Technology

Grant Number:

5R01DK052985-28

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/10/1997

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY ABSTRACT Urolithiasis imposes a substantial and growing public health burden in the United States with a prevalence nearly doubled over the past 15 years, impacting now 1 in 11 Americans in their lifetime. Shock wave lithotripsy (SWL) remains to be the only non-invasive treatment option for ...

Research Terms

<3-D><3-Dimensional><3D><Achievement><Achievement Attainment><Acoustics><Address><American><Anatomic Sites><Anatomic structures><Anatomy><Award><Benign><Book Chapters><CHRM3><CHRM3 gene><Cell Body><Cells><Characteristics><Circulatory Collapse><Clinic><Clinical><Clinical Management><Clinical Treatment><Clinical Trials><Collaborations><Comment><Commentary><Computer Models><Computerized Models><Coupling><Development and Research><Devices><Disease><Disorder><Dose><Dryness><ED visit><ER visit><Editorial Comment><Electromagnetics><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><Ensure><Feedback><Fracture><Frequencies><Gel><Generations><Genitourinary Diseases><HESW><HM3><Health Care Costs><Health Costs><High-Energy Shock Waves><Injury><Journals><Kidney><Kidney Calculi><Kidney Stones><Kidney Urinary System><Knowledge><Laser Lithotripsy><Length of Life><Litholapaxy><Lithotripsy><Longevity><Magazine><Manufacturer><Microfluidics><Modality><Monitor><Motion><NIH><National Institutes of Health><Pain><Painful><Paper><Patients><Percutaneous Nephrolithotomy><Performance><Physics><Physiologic pulse><Play><Prevalence><Procedures><Public Health><Published Comment><Publishing><Pulse><R & D><R&D><Recurrence><Recurrent><Renal Calculi><Renal Stone><Renal Tissue><Reoperation><Repeat Surgery><Research><Research Activity><Residual><Residual state><Risk><Role><Safety><Shapes><Shock><Skin><Source><Surface><Surgical Management><System><Techniques><Technology><Time><Transmission><Treatment Protocols><Treatment Regimen><Treatment Schedule><Treatment outcome><United States><United States National Institutes of Health><Ureteroscopy><Urinary Calculi><Urinary Stones><Urinary Tract Stones><Urogenital Diseases><Urolith><Urologist><Viewpoint><Width><bone fracture><circulatory shock><clinical intervention><clinical therapy><computational modeling><computational models><computer based models><computerized modeling><cost><cost effective><design><designing><flexibility><flexible><improved><injuries><injury to tissue><innovate><innovation><innovative><intervention design><lens><lenses><materials science><new technology><next generation><novel><novel technologies><pressure><programs><real time monitoring><realtime monitoring><renal><research and development><respiratory><shocks><smart technologies><social role><synergism><tech development><technological innovation><technology development><therapy design><therapy optimization><three dimensional><tissue injury><translational opportunities><translational potential><transmission process><treatment design><treatment optimization><treatment strategy><trial regimen><trial treatment><ultrasound><urolithiasis><urologic><urological><µfluidic>
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SUZANNE M. DE LA MONTE

RHODE ISLAND HOSPITAL, PROVIDENCE, RI

Good lead · 46/100
Likely hiring
Solid budget
Active award
$366,750
FY 2025

Project Title

FASD Inhibition of ASPH-Notch Mediates Adolescent Cerebral White Matter Pathology-Potential Utility of Non-invasive Extracellular Vesicle Assays

Grant Number:

5R01AA011431-26

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/1996

End Date:

3/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Long-term effects of fetal alcohol spectrum disorder (FASD) on the CNS vary with exposure dose, duration, and timing. Despite decades of research, we still lack efficient means of detecting and therapeutically targeting the damage. However, progress may have been limited by our failure to attend to ...

Research Terms

<1-Phosphatidylinositol 3-Kinase><12-20 years old><Absolute ethanol><Address><Adhesions><Adolescence><Adolescent><Adolescent Development><Adolescent Youth><Adverse effects><Alcohol Chemical Class><Alcohols><Assay><Axon><Behavior><Bioassay><Biological Assay><Biological Markers><Blood Serum><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain Pathology><CNS Diseases><CNS disorder><Cell Body><Cell Communication and Signaling><Cell Death><Cell Locomotion><Cell Migration><Cell Movement><Cell Signaling><Cells><Cellular Migration><Cellular Motility><Central Nervous System Diseases><Central Nervous System Disorders><Ceramides><Cerebrum><Chronic><Cognitive><Data><Development><Diagnosis><Disease><Disorder><Dose><Dysfunction><ELISA><ETOH><Electron Microscopy><Encephalon><Encephalon Diseases><Enzyme-Linked Immunosorbent Assay><Ethanol><Ethyl Alcohol><Experimental Models><FASD><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Failure><Female><Fetal Alcohol Exposure><Fetal Alcohol Spectrum Disorder><Fetal ETOH Exposure><Fetal Ethanol Exposure><Functional disorder><Funding><Genes><Grain Alcohol><Human><Humulin R><Hydroxylases><IGF-1><IGF-I><IGF-I-SmC><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><In Utero Alcohol Exposure><In Utero ETOH Exposure><In Utero Ethanol Exposure><Injury><Insulin><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Somatomedin Peptide I><Intermediary Metabolism><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Link><Lipids><Long-Evans Rats><Long-Term Effects><MALD-MS><MALDI><MALDI-MS><Maintenance><Mechanistic Target of Rapamycin><Mediating><Messenger RNA><Metabolic><Metabolic Processes><Metabolism><Methylcarbinol><Mixed Function Oxidases><Mixed Function Oxygenases><Modeling><Modern Man><Monitor><Monooxygenases><Motor><Myelin><Nerve Cells><Nerve Unit><Neural Cell><Neurocognitive><Neurocyte><Neuronal Migration Disorder><Neurons><Non-Invasive Detection><Noninvasive Detection><Novolin R><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Oxidative Stress><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><Pathology><Pathway interactions><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Physiopathology><Predisposition><Prenatal Alcohol Exposure><Prenatal ETOH Exposure><Prenatal Ethanol Exposure><Proteins><PtdIns 3-Kinase><RAFT1><Regular Insulin><Regulation><Research><Role><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Somatomedin C><Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization><Spectroscopy, Mass, Matrix-Assisted Laser Desorption-Ionization><Sphingolipids><Sphingomyelins><Structure><Sulfatides><Sulfatoglycosphingolipids><Sulfoglycosphingolipids><Susceptibility><Synapses><Synaptic><Therapeutic><Therapeutic Intervention><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><adolescence (12-20)><alcohol effect><alcohol exposed><alcohol exposure><alcohol-exposed pregnancy><bio-markers><biologic marker><biological signal transduction><biomarker><cell motility><cerebral><clinical applicability><clinical application><clinical relevance><clinically relevant><developmental><dysmyelinating><dysmyelination><enzyme linked immunoassay><ethanol effect><ethanol exposed><ethanol exposure><exosome><experiment><experimental research><experimental study><experiments><exposed to alcohol><exposed to alcohol prenatally><exposed to ethanol><exposure to alcohol><exposure to ethanol><extracellular vesicles><gestation ETOH exposure><gestation alcohol exposure><gestation ethanol exposure><gestational ethanol exposure><in vivo><injuries><innovate><innovation><innovative><intervention therapy><juvenile><juvenile human><life span><lifespan><lipidomics><mRNA><mTOR><male><mammalian target of rapamycin><matrix assisted laser desorption ionization><migration><migration disorder><motor deficit><necrocytosis><neural inflammation><neurobehavioral><neuroinflammation><neuroinflammatory><neuronal><neuronal survival><non-invasive diagnosis><non-invasive diagnostic><noninvasive diagnosis><noninvasive diagnostic><notch><notch protein><notch receptors><novel><pathophysiology><pathway><peripheral blood><postnatal><pregnancy ETOH exposure><pregnancy alcohol exposure><pregnancy ethanol exposure><prenatally alcohol exposed><prenatally exposed to alcohol><response to therapy><response to treatment><sex><social role><stem><substantia alba><success><synapse><therapeutic response><therapeutic target><therapy response><tool><treatment response><treatment responsiveness><white matter><♀><♂>
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Beatrice H Hahn

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 44/100
Likely hiring
Above-average budget
$802,293
FY 2022

Project Title

Exploiting the antigenic conservation of the Env trimer apex across primate lentiviral lineages for AIDS vaccine design

Grant Number:

5R01AI050529-20

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2001

End Date:

6/30/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Studying Natural SIV Reservoirs and Human Zoonotic Risk, we discovered in the last funding period that certain strains of SIV infecting Old World monkeys and African apes share unexpected antigenic cross- reactivity with HIV-1 in the functionally important V1V2 region of the envelope...

Research Terms

<AIDS><AIDS Vaccines><AIDS Virus><AIDS vaccine><AIDS vaccine development><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immuno-Deficiency Syndrome><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Acquired Immunologic Deficiency Syndrome><Affinity><African><Antibodies><Antigenic Determinants><Antigens><Apes><Autologous><Award><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Behavior><Binding><Binding Determinants><Biology><Bionomics><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cameroon><Cell Body><Cell surface><Cells><Central Africa><Cercopithecidae><Chimp><Chimpanzee><Clinical Evaluation><Clinical Testing><Collection><Communities><Complement><Complement Proteins><Consensus><Country><Data><Development><Ecology><Epitopes><Funding><Genetic><Genome><Glycoproteins><Goals><Gorilla gorilla><Gorillas><Grant><HIV><HIV Envelope Glycoprotein gp120><HIV Envelope Protein gp120><HIV env Protein gp120><HIV-1><HIV-1 vaccine><HIV-I><HIV1><HIV1 vaccine><HTLV-III gp120><History><Human><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Immunization><Immunize><Immunobiology><Immunogenetics><Immunologic Sensitization><Immunologic Stimulation><Immunological Sensitization><Immunological Stimulation><Immunophysiology><Immunostimulation><In Vitro><KI mice><Kinetics><Knock-in><Knock-in Mouse><Knowledge><LAV-HTLV-III><Lymphadenopathy-Associated Virus><M mulatta><M. mulatta><Macaca mulatta><Malaria><Maps><Mediating><Messenger RNA><Mice><Mice Mammals><Modern Man><Molecular Epidemiology><Molecular Interaction><Monkeys><Murine><Mus><NIH><National Institutes of Health><Old World Monkeys><P falciparum><P vivax><P. falciparum><P. vivax><P.falciparum><Paludism><Pan Genus><Pan Species><Parasites><Pathogenicity><Pattern><Phase><Plasmodium Infections><Plasmodium falciparum><Plasmodium vivax><Pongidae><Primate Immunodeficiency Viruses><Primate Lentiviruses><Primates><Primates Mammals><Production><Protomer><Public Health><Publications><Recording of previous events><Research><Research Specimen><Rhesus Macaque><Rhesus Monkey><Risk><SHIV><SIV><Scientific Publication><Simian Immunodeficiency Viruses><Specimen><Spinal Column><Spine><Structure><T-Cell Depletion><T-cell depletion therapy><T-lymphocyte depletion therapy><T4 Cells><T4 Lymphocytes><Tail><Testing><Time><Transmission><United States National Institutes of Health><Vaccine Design><Vertebral column><Viral Diseases><Viral Pathogenesis><Viral reservoir><Virus><Virus Diseases><Virus reservoir><Virus-HIV><Virus-like particle><Work><Zoonoses><Zoonotic><Zoonotic Infection><backbone><base><clinical test><cross reactivity><develop a vaccine><develop vaccines><development of a vaccine><developmental><gene function><gp120><gp120 ENV Glycoprotein><gp120(HIV)><gp160><great ape><immunogen><immunogenicity><knockin><knockin mice><mRNA><microbial consortia><microbial flora><microbiota><microflora><multispecies consortia><neutralizing antibody><new approaches><novel><novel approaches><novel strategies><novel strategy><pandemic><pandemic disease><pathogen><research clinical testing><response><simian HIV><simian human immunodeficiency virus><transmission process><vaccine development><viral infection><virus infection><virus pathogenesis><virus-induced disease><virus-like nanoparticles><viruslike particle>
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Serpil C. Erzurum

CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH

Exploratory lead · 44/100
Likely hiring
Above-average budget
$759,106
FY 2023

Project Title

Nitric Oxide in Pulmonary Hypertension

Grant Number:

5R01HL060917-24

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/1999

End Date:

12/31/2025

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT This is a competitive renewal of our R37 MERIT (2009-2019), which aims to define mechanisms of Pulmonary Arterial Hypertension (PAH). Our work led to new knowledge, shared resources and methods, including a critical advance in harvest and culture of human pulmonary artery endothelial cells ...

Research Terms

<2,5-Diaminopentanoic Acid><ARG2><ARG2 gene><Affect><Altitude><Arginine><Award><Big Data><BigData><Bioavailability><Bioenergetics><Biological Availability><Blood><Blood Reticuloendothelial System><Cardiac><Cell Body><Cells><Cellular Metabolic Process><Cessation of life><Citric Acid Cycle><D-Glucose><Data><Death><Dependence><Development><Dextrose><Disease><Disorder><Dysfunction><ECSF><ENOS><Electron Transport><Endogenous Nitrate Vasodilator><Endothelial Nitric Oxide Synthase><Endothelium><Endothelium-Derived Nitric Oxide><Epoetin><Erythropoietin><FDG PET><Functional disorder><Glucose><Glutamates><Goals><Grant><Harvest><Hemoglobin><Hepatic Proliferation Inhibitor><Human><Hypoxia><Hypoxia Inducible Factor><Hypoxic><Intermediary Metabolism><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Knowledge><Krebs Cycle><L arginine amidinohydrolase><L-Arginine><L-Glutamate><Left><Link><Liver Immunoregulatory Protein><Liver-Derived Inhibitory Protein><Lung><Lung Respiratory System><Measures><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Pathway><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Mitochondria><Modern Man><Mononitrogen Monoxide><Multiomic Data><Murine><Mus><NOS3><NOS3 gene><Nature><Network Analysis><Nitric Oxide><Nitric Oxide Synthase 3><Nitrogen Monoxide><Nitrogen Protoxide><Non-Polyadenylated RNA><Null Mouse><Ornithine><Oxygen Consumption><Oxygen Deficiency><Pathologic><Pathway Analysis><Pathway interactions><Patients><Persons><Phenotype><Phosphorylation><Physiologic Availability><Physiopathology><Production><Productivity><Proliferating><Protein Phosphorylation><Proteins><Pulmonary Hypertension><RNA><RNA Gene Products><Resistance><Resource Sharing><Respiration><Ribonucleic Acid><Right Ventricular Dysfunction><Right heart dysfunction><Right ventricle dysfunction><Right-sided heart dysfunction><System><Systolic Pressure><TCA cycle><Testing><Thesaurismosis><Transplantation><Tricarboxylic Acid Cycle><Tricarboxylic Acids><Type III nitric oxide synthase><Vasodilating Agent><Vasodilator Agents><Vasodilator Drugs><Vasodilators><Ventricular><Wild Type Mouse><Woman><Work><aerobic glycolysis><arginase><arginase 2><arginase II><arginine amidinase><canavanase><cell metabolism><cellular metabaolism><developmental><differential expression><differentially expressed><electron transfer><endothelial cell derived relaxing factor><erythrocyte colony stimulating factor><experiment><experimental research><experimental study><experiments><fluorodeoxyglucose PET><fluorodeoxyglucose positron emission tomography><glucose uptake><glutamatergic><hematopoietin><hypoxia-induced pulmonary hypertension><hypoxic pulmonary hypertension><improved><in vivo><lung pressure><lung vascular cells><metabolism disorder><metabolism measurement><metabolomics><metabonomics><method development><mitochondrial><multiomics><multiple omic data><multiple omics><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><oxidation><pathophysiology><pathway><protection pathway><protective pathway><pulmonary><pulmonary arterial endothelial cell><pulmonary arterial hypertension><pulmonary artery endothelial cell><pulmonary artery hypertension><pulmonary pressure><pulmonary vascular cells><resistant><respiratory mechanism><therapeutic target><trait><transcriptional differences><transcriptomics><transplant><uptake><wildtype mouse>
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ELAINE FUCHS

ROCKEFELLER UNIVERSITY, NEW YORK, NY

Exploratory lead · 44/100
Likely hiring
Above-average budget
$726,514
FY 2022

Project Title

Cell adhesion and cytoskeletal dynamics in the skin

Grant Number:

5R01AR027883-44

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/1980

End Date:

8/31/2023

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Our global objective is to develop a molecular understanding of how epithelial stem cells undergo morphogenesis and maintain homeostasis in mammalian skin, and to bring our research to a clinical setting. Our focus is on how, in response to local developmental cues, skin stem cells r...

Research Terms

<21+ years old><Actomyosin><Address><Adherens Junction><Adhering Junction><Adhesions><Adhesive Junction><Adult><Adult Human><Affect><Anchoring Junction><Autoregulation><Award><Basement membrane><Benign><Beta Cadherin-Associated Protein><Beta-1 Catenin><Biology><Body Tissues><CRISPR><CRISPR/Cas system><CUL-2><Cancers><Cats><Cats Mammals><Cell Adhesion><Cell Body><Cell Communication and Signaling><Cell Density><Cell Differentiation><Cell Differentiation process><Cell Shape><Cell Signaling><Cell division><Cells><Cellular Adhesion><Cellular Matrix><Cellular Mechanotransduction><Chromatin><Clinical><Clinical Trials><Clustered Regularly Interspaced Short Palindromic Repeats><Complex><Coupled><Coupling><Crowding><Cues><Cutaneous Disorder><Cyclicity><Cytoskeletal System><Cytoskeleton><Daughter><Dermatoses><Development><Diagnosis><Differentiation and Growth><Disease><Disorder><Domestic Cats><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Epidermis><Epidermoid Carcinoma><Epithelial><Equilibrium><Failure><Family member><Feline Species><Felis catus><Felis domestica><Felis domesticus><Felis sylvestris catus><Film><Future><Genes><Genetic><Grant><Hair><Hair Follicle><Hair follicle structure><Health><Homeostasis><Human><Image><Immunofluorescence><Immunofluorescence Immunologic><Intracellular Communication and Signaling><Knowledge><Lead><Maintenance><Malignant><Malignant - descriptor><Malignant Neoplasms><Malignant Skin Neoplasm><Malignant Tumor><Maps><Math Models><Mechanical Signal Transduction><Mechanosensory Transduction><Mesenchymal><Methods><Mice><Mice Mammals><Modern Man><Molecular><Molecular Genetics><Monitor><Morphogenesis><Movement><Murine><Mus><Normal Tissue><Normal tissue morphology><Nuclear><Oncogenesis><PRO2286><Papilloma><Pb element><Periodicity><Physiologic><Physiological><Physiological Homeostasis><Planocellular Carcinoma><Plant Roots><Play><Production><Progenitor Cells><Property><Proteins><RNA Seq><RNA interference screen><RNA sequencing><RNAi screen><RNAi-based screen><RNAseq><Research><Resistance><Rhythmicity><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Skin Cancer><Skin Diseases><Skin Diseases and Manifestations><Skin development><Skin repair><Squamous Carcinoma><Squamous Cell Epithelioma><Squamous cell carcinoma><Stratification><Surface><Technology><Tissues><Transcript><WNT Signaling Pathway><WNT signaling><Work><adulthood><balance><balance function><base><beta catenin><biological signal transduction><body movement><cofilin><conditional knock-out><conditional knockout><cutaneous barrier><cutaneous disease><cutaneous repair><density><dermal barrier><dermal disease><dermal disorder><dermal repair><developmental><driving force><epidermal barrier><epithelial progenitor cell><epithelial stem cell><fitness><gene function><genetic approach><genetic strategy><hair regeneration><heavy metal Pb><heavy metal lead><imaging><improved><in utero><inhibitor><insight><intracellular skeleton><malignancy><malignant skin tumor><mathematic model><mathematical model><mathematical modeling><mechanical cue><mechanical signal><mechanosensing><mechanotransduction><monolayer><morphogenetic process><mouse genetics><neoplasm/cancer><planar cell polarity><progenitor><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><resistant><response><rho><rho G-Proteins><rho GTP-Binding Proteins><rho GTPases><rho Protein P21><rho Small GTP-Binding Proteins><root><self-renew><self-renewal><sensor><skin barrier><skin disorder><skin morphogenesis><skin organogenesis><social role><stem cell fate><stem cells><success><tissue regeneration><tissue regrowth><tissue renewal><tissue repair><tissue specific regeneration><tool><transcriptome sequencing><tumorigenesis><β-catenin>
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MICHAEL L. DENNIS

CHESTNUT HEALTH SYSTEMS, INC., BLOOMINGTON, IL

Exploratory lead · 44/100
Likely hiring
Above-average budget
$509,350
FY 2022

Project Title

Smartphone Addiction Recovery Coach for Young Adults (SARC-YA) Experiment

Grant Number:

5R01DA011323-19

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/1999

End Date:

5/31/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Adolescents who receive treatment for substance use disorders (SUD) have high rates of resuming substance use after they leave treatment. Although relapse prevention is widely incorporated within SUD treatment for adolescents, tools for sustaining recovery are frequently lacking or inadequ...

Research Terms

<12-20 years old><21+ years old><Abstinence><Address><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><After Care><After-Treatment><Aftercare><Age><Ambulatory Care><Award><Behavioral><Brain><Brain Nervous System><Car Phone><Caring><Cell Phone><Cellular Phone><Cellular Telephone><Cognition><DALY><Data><Development><Disease><Disorder><E-Mail><Ecological momentary assessment><Educational process of instructing><Electronic Mail><Email><Emotional well being><Encephalon><Environment><Equation><Failure><Feedback><Feeling><Feels well><Frequencies><Future><HIV risk><Health><Health Care Costs><Health Costs><Healthcare Costs><Internet><Intervention><Intervention Strategies><Lead><Length><Maintenance><Mediating><Mental disorders><Mental health disorders><Metadata><Mobile Phones><Modeling><Modernization><Monitor><Morbidity><Morbidity - disease rate><Motivation><Normal mental condition><Normal mental state><Normal psyche><Outpatient Care><Participant><Patient Self-Report><Pattern><Pb element><Performance><Persons><Pilot Projects><Psychiatric Disease><Psychiatric Disorder><Psychological Well Being><QOL><Quality of life><Randomized><Recovery><Recovery Support><Relapse><Reporting><Research><Risk><Risk Behaviors><Risky Behavior><Schools><Self Efficacy><Self-Report><Sense of well-being><Services><Social Network><Societies><Standardization><Substance Use Disorder><Survival Analyses><Survival Analysis><Symptoms><Teaching><Test Result><Testing><Text><Text Messaging><Thinking><Time><Urine><Urine Urinary System><WWW><Well in self><Withdrawal><Youth><Youth 10-21><addiction><addictive disorder><adolescence (12-20)><adolescent substance use><adult youth><adulthood><ages><at risk behavior><base><cognitive development><cost><craving><developmental><disability-adjusted life years><disease recurrence prevention><disorder later incidence prevention><disorder recurrence prevention><efficacy analysis><efficacy assessment><efficacy evaluation><efficacy examination><electronic communication><emotional wellbeing><emotional wellness><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><feelings><heavy metal Pb><heavy metal lead><help seeking><help-seeking behavior><iPhone><improved><intervention participants><interventional strategy><juvenile><juvenile human><mental illness><mental well-being><mental wellbeing><mental wellness><meta data><methods to study multiple-level influences><mobile app><mobile application><mobile device application><mortality><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><outpatient treatment><pilot study><post treatment><prevent><preventing><psychiatric illness><psychological disorder><psychological wellbeing><psychological wellness><randomisation><randomization><randomly assigned><recruit><recurrence prevention><reduced substance use><reduction in substance use><relapse prevention><response><self wellness><sense of wellbeing><short message service><smart phone><smartphone><substance use><substance use among adolescents><substance use among youth><substance use reduction><substance use treatment><substance using><texting><thoughts><tool><treatment program><web><world wide web><young adult><young adulthood><youth substance use>
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Ting Bao

DANA-FARBER CANCER INST, BOSTON, MA

Exploratory lead · 40/100
Above-average budget
Recent
Active award
$659,998
FY 2026

Project Title

Acupuncture for Chemotherapy-induced Peripheral Neuropathy Treatment (ACT)

Grant Number:

4R37CA248563-06

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

R37 extension summary The supplementary study to the R37 ACT trial aims to explore the neurobiological mechanisms behind acupuncture's effectiveness in alleviating chemotherapy-induced peripheral neuropathy (CIPN) pain, focusing on modulating both peripheral and central pain mechanisms. The study ha...

Research Terms

<ASCO><Active Follow-up><Acupuncture Therapy><Acupuncture procedure><Affect><American Society of Clinical Oncology><Analgesia Tests><Analgesic Agents><Analgesic Drugs><Analgesic Preparation><Analgesics><Anodynes><Antinociceptive Agents><Antinociceptive Drugs><Brief Pain Inventory><Cancer Center><Cancer Patient><Cancer Survivor><Cancers><Central Lobe><Cephalalgia><Cephalgia><Cephalodynia><Chemotherapy-induced peripheral neuropathy><Chinese Traditional Medicine><Chinese medicine><Chung I Hsueh><Clinical><Clinical Trials><Clinical Trials Design><Complication><Cranial Pain><Data><Dermatologic biopsy><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Drugs><Effectiveness><Electroacupuncture><Fatigue><Fiber><Functional MRI><Functional Magnetic Resonance Imaging><Future><Goals><Head Pain><Headache><Hour><Impairment><Inflammatory><Insula><Insula of Reil><Integrative Medicine><Intervention><Island of Reil><Lack of Energy><Long-term Follow-up><Loss of Sensation><Malignant Neoplasms><Malignant Tumor><Measurement><Measures><Medication><Nausea><Nerve Fibers><Neurobiology><Nociception Tests><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Numbness><Numeric Rating Scale><Numerical Scale><Pain><Pain Assessment><Pain Measurement><Pain Threshold><Pain Tolerance Level><Pain measure><Painful><Participant><Patient Care><Patient Care Delivery><Patient Preferences><Patients><Peripheral><Pharmaceutical Preparations><Pilot Projects><Placebos><Prediction of Response to Therapy><QOL><QOL improvement><Quality of life><Randomized, Controlled Trials><Recommendation><Research><Role><Sample Size><Scientist><Sensory><Severities><Sham Treatment><Solid Neoplasm><Solid Tumor><Symptoms><Tactile><Techniques><Testing><United States><Zhong Yi Xue><active followup><acupuncture><arm><blind><care as usual><care for patients><care of patients><care providers><caring for patients><central pain><chemotherapy><chronic MSK pain><chronic musculoskeletal pain><cingulate cortex><conditioned pain modulation><cortical pain><cutaneous biopsy><density><design><designing><determine efficacy><drug/agent><duloxetine><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experience><fMRI><follow up><follow-up><followed up><followup><head ache><improved><improvements in QOL><improvements in quality of life><integrative healing><integrative health><lipidomics><long-term followup><malignancy><metabolism measurement><metabolomics><metabonomics><minimally invasive><multidisciplinary><neoplasm/cancer><neurobiological><neurobiological mechanism><neuropathic pain><neurotoxic><new approaches><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><novel approaches><novel strategies><novel strategy><outcome prediction><pain assay><pain killer><pain medication><pain processing><pain reduction><pain reliever><pain tolerance><painful neuropathy><painkiller><peripheral pain><personalized chemotherapy><pharmacologic><pilot study><placebo controlled study><precision chemotherapy><predict responsiveness><predict therapeutic response><predict therapy response><predicting response><pressure><primary outcome><quality of life improvement><randomized control trial><randomized placebo-controlled clinical trial><reduce pain><response to therapy><response to treatment><sham therapy><side effect><skin biopsy><social role><standard of care><therapeutic response><therapy prediction><therapy response><treatment as usual><treatment effect><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><usual care><vibration>
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William A Petri

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Exploratory lead · 40/100
Above-average budget
Recent
Active award
$558,597
FY 2026

Project Title

Role of CREM in Amebic Colitis and Inflammatory Bowel Disease

Grant Number:

5R37AI026649-36

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/1989

End Date:

12/31/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Approach: We propose to continue our study of how the human transcription factor CR E M (cAMP responsive element modulator) contributes to the innate immune response to protect from colitis due to E ntamoeba histolytica and further explore its role in inflammatory bowel disease. Successful completio...

Research Terms

<0-11 years old><21+ years old><3'5'-cyclic ester of AMP><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adult><Adult Human><Affect><Amebiasis><Amebic Dysentery><Amebic colitis><American><B220><Bacillary Dysentery><Bacteria><Bangladesh><Basal Transcription Factor><Basal transcription factor genes><Bile Acids><Birth><Blood Eosinophil><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><CD45><CRE Recombinase><CREM protein><CUL2><CUL2 gene><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Child><Child Youth><Children (0-21)><Colitis><Collaborations><Communication><Cryptosporidiosis><Cryptosporidium infection><Cyclic AMP><Cyclic AMP Response Element><Cyclic AMP Response Element Modulator><DNA mutation><Data><Development><Diarrhea><Differential Gene Expression><Disease><Disorder><E histolytica><E. histolytica><Endamoeba histolytica><Entamoeba histolytica><Enterobacteria phage P1 Cre recombinase><Eosinophilic Granulocyte><Eosinophilic Leukocyte><Epithelium><Expression Signature><GI microbiome><GP180><GTEx><GWA study><GWAS><Gene Expression><Gene Expression Profile><Gene Transcription><Gene variant><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Change><Genetic Diversity><Genetic Transcription><Genetic Variation><Genetic defect><Genetic mutation><Genotype><Genotype-Tissue Expression Project><Goals><Goblet Cells><Human><Human Genetics><ICER protein><ICERI protein><Immune><Immunes><Immunity><In Vitro><Infection><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Injury><Innate Immune Response><Innate Immunity><Instruction><Intestinal><Intestinal Amebiasis><Intestines><Intracellular Communication and Signaling><Investigation><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><LY5><Life><Link><Lymphoid Cell><Macrophage><Maps><Marrow Eosinophil><Mediating><Mediator><Mice><Mice Mammals><Modern Man><Murine><Mus><Mutation><Mφ><Names><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Null Mouse><PTPRC><PTPRC gene><Parasites><Parasitology><Parturition><Pathway interactions><Patients><Predisposition><Predisposition gene><Principal Investigator><Publications><QTL><Quantitative Trait Loci><RNA Expression><RNA interference screen><RNAi screen><RNAi-based screen><Reporting><Resistance><Risk Factors><Role><Scientific Publication><Screening Result><Shigella Dysentery><Shigella Infections><Signal Transduction><Signal Transduction Systems><Signaling><Single cell seq><Subgroup><Susceptibility><Susceptibility Gene><T200><Tamoxifen><Testing><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Variant><Variation><Work><adenosine 3'5' monophosphate><adulthood><allelic variant><bacteriophage P1 recombinase Cre><biological signal transduction><bowel><cAMP><cAMP Response Element><cAMP-responsive element modulator><cell type><child patients><choleate><cohort><conditional knock-out><conditional knockout><deoxycholate><developmental><diarrheal disease><diarrheal illness><digestive tract microbiome><enteric microbiome><entire genome><eosinophil><exome sequencing><exome-seq><full genome><gastrointestinal microbiome><gene expression pattern><gene expression signature><genetic epidemiologic study><genetic epidemiology><genetic variant><genome mutation><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic variant><gut microbiome><gut-associated microbiome><in vivo><infected with Cryptosporidium><inflammatory disease of the intestine><inflammatory disorder of the intestine><injuries><innovate><innovation><innovative><intestinal autoinflammation><intestinal biome><intestinal epithelium><intestinal microbiome><job environment><kids><microbiome><mouse model><murine model><name><named><naming><new approaches><novel approaches><novel strategies><novel strategy><pathway><pediatric patients><pleiotropic effect><pleiotropism><pleiotropy><predisposing gene><professional atmosphere><programs><promoter><promotor><public health relevance><resistant><response><shigellosis><single cell next generation sequencing><single cell sequencing><social role><susceptibility allele><susceptibility locus><susceptibility variant><targeted sequencing><trait><transcription factor><transcriptional profile><transcriptional signature><villin><whole genome><whole genome association analysis><whole genome association study><work atmosphere><work environment><workplace climate><workplace environment><youngster>
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May Hua

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 40/100
Above-average budget
Recent
Active award
$521,713
FY 2026

Project Title

Determinants of Palliative Care Effectiveness for Patients with Metastatic Cancer

Grant Number:

4R37CA246565-06

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/3/2021

End Date:

1/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Palliative care is an interdisciplinary model of care with the overarching goal of improving quality of life for patients with serious illness through symptom management, provision of psychosocial support, elicitation of preferences and aiding decision-making. The American Society of...

Research Terms

<ASCO><Advanced Cancer><Advanced Malignant Neoplasm><Affect><American Society of Clinical Oncology><Artifacts><Award><Cancer Center><Cancer Hospital><Cancers><Caring><Certification><Characteristics><Clinical><Collection><Consultations><Data><Data Bases><Data Sources><Databases><Decision Making><Disparities><Disparity><Disseminated Malignant Neoplasm><Effectiveness><Electronics><Enrollment><Ensure><Equity><Future><Generalized Growth><Goals><Growth><Guidelines><Health Care Utilization><Heterogeneity><Hospitals><Institution><Intensive Care Units><Interview><Investigation><Knowledge><Length><Life><Link><Malignant Neoplasms><Malignant Tumor><Measures><Mediation><Medicare claim><Metastatic Cancer><Metastatic Malignant Neoplasm><Modeling><Morphologic artifacts><NCI Organization><National Cancer Institute><Negotiating><Negotiation><Out-patients><Outcome><Outpatients><PDQ Information System><Palliative Care><Palliative Therapy><Palliative Treatment><Pathway interactions><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Persons><Physician Data Query><Population><Protocol><Protocols documentation><Provider><Proxy><Psychosocial Assessment and Care><QOC><QOL><QOL improvement><Qualitative Research><Quality of Care><Quality of life><Recommendation><Registries><Research><Research Methodology><Research Methods><Scientific Advances and Accomplishments><Site><Site Visit><Specialist><Targeted Research><Time><Tissue Growth><United States><Visit><Writing><access disparities><accessibility disparities><acute care><cancer care><care costs><care delivery><care for patients><care of patients><care services><care systems><caring for patients><chemotherapy><cohort><comfort care><consultation><data base><disparities in access><electronic><electronic device><end of life><end of life care><end-of-life><enroll><future implementation><health care service use><health care service utilization><hospice enrollment><hospice use><hospice utilization><hospital care><hospital re-admission><hospital readmission><improved><improvements in QOL><improvements in quality of life><inequality in access><inequity in access><inequity in accessibility><informant><insight><malignancy><manage symptom><neoplasm/cancer><novel><ontogeny><palliative intervention><pathway><patient oriented outcomes><patient population><preference><programs><prospective><psychosocial assessment><psychosocial care><psychosocial studies><psychosocial support><quality of life improvement><re-admission><re-hospitalization><readmission><rehospitalization><research and methods><scientific accomplishments><scientific advances><symptom management><symptomatology>
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Michael R. Bruchas

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$426,589
FY 2026

Project Title

DISSECTING DYNORPHIN-KAPPA OPIOID MEDIATED REINSTATEMENT OF NICOTINE PREFERENCE

Grant Number:

5R37DA033396-14

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2013

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Despite recent efforts to curb use, nicotine use is at an all time high, is responsible for millions of deaths each year and remains one of the most difficult drugs to stop using. While there are many reports of opioid receptor, specifically Kappa-opioid receptor dependent regulation of drug-seeking...

Research Terms

<Adeno-Associated Viruses><Affective Disorders><Alcohol Chemical Class><Alcohols><Ammon Horn><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anxiety><Associated Viruses><Behavior><Behavioral><Behavioral Model><Biological><Brain><Brain Nervous System><CRE Recombinase><CRISPR><CRISPR/Cas system><CaM KII><CaM PK II><CaM kinase II><CaMKII><Calcium><Cartoons><Cell Body><Cells><Cessation of life><Chemosensitization><Chemosensitization/Potentiation><Claustral structure><Claustrum><Clustered Regularly Interspaced Short Palindromic Repeats><Cocaine><Cornu Ammonis><Corpus Striatum><Corpus striatum structure><Death><Dependoparvovirus><Dependovirus><Diacetylmorphine><Diamorphine><Dorsal><Drug Regulations><Drug abuse><Drugs><Dynorphins><Electrophysiology><Electrophysiology (science)><Encephalon><Enterobacteria phage P1 Cre recombinase><Genetic><Glutamates><Heroin><Hippocampus><Image><In vivo two-photon calcium imaging><Instruction><L-Glutamate><Learning><Ligands><Link><Measures><Mediating><Medication><Memory><Methods><Mice><Mice Mammals><Modeling><Mood Disorders><Motivation><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuropharmacology><Neurophysiology / Electrophysiology><Nicotine><Nicotine Dependence><Nucleus Accumbens><Opiate Addiction><Opiate Dependence><Opiate Peptides><Opiate Receptors><Opiate agonist><Opiate receptor agonist><Opiates><Opioid><Opioid Peptide><Opioid Receptor><Opioid agonist><Opioid receptor agonist><Outcome><Pharmaceutical Preparations><Pharmacology><Photometry><Play><Potentiation><Process><Receptor Activation><Receptor Protein><Regulation><Relapse><Reporting><Rewards><Risk><Role><Satellite Viruses><Self Administered><Self Administration><Site><Slice><Stress><Striate Body><Striatum><Synapses><Synaptic><Synaptic plasticity><System><Testing><Therapeutic Intervention><Time><Tobacco><Ventral Striatum><Viral><Work><abuse of drugs><abused drug><abused drugs><abuses drugs><adeno associated virus group><amygdaloid nuclear complex><bacteriophage P1 recombinase Cre><biologic><calcium-dependent CaM kinase II><calmodulin-dependent protein kinase II><cell type><drug abused><drug of abuse><drug seeking behavior><drug/agent><drugs abused><drugs of abuse><electrophysiological><endogenous opiate><endogenous opioids><endomicroscopy><experience><experiment><experimental research><experimental study><experiments><gain of function><genetic approach><genetic strategy><glutamatergic><hippocampal><imaging><in vivo><in vivo calcium imaging><interdisciplinary approach><intervention therapy><kappa opiate><kappa opioid><kappa opioid receptors><lead candidate><microendoscopy><mouse genetics><mouse model><multidisciplinary approach><murine model><neural circuit><neural circuitry><neurocircuitry><neuronal><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><nicotine addiction><nicotine consumption><nicotine dependent><nicotine reward><nicotine seeking><nicotine seeking behavior><nicotine self-administration><nicotine treatment><nicotine use><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><opioid addiction><opioid dependence><opioid dependent><optogenetics><parabrachial nucleus><pharmacologic><preference><presynaptic><receptor><receptor expression><recruit><social role><striatal><synapse><synaptic circuit><synaptic circuitry><viral rescue><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR>
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Jane B. Lian

UNIVERSITY OF VERMONT & ST AGRIC COLLEGE, BURLINGTON, VT

Exploratory lead · 36/100
Likely hiring
Solid budget
$496,258
FY 2024

Project Title

Chromatin Organization Regulates Osteogenesis

Grant Number:

5R01DE029311-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/6/2020

End Date:

12/31/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY This new R01 builds on discoveries during the R37 period (2008-2018) that established epigenetic mechanisms (miRNAs, histone modifications) regulating osteoblast differentiation. We characterized for the first time a “signature” of specific histone modifications that are associated with dyna...

Research Terms

<Acetylation><Acute><Affect><Aging><Alkaline Phosphatase><Assay><Basal Transcription Factor><Basal transcription factor genes><Binding><Bioassay><Biological Assay><Body Tissues><Bone Development><Bone Formation><Bone Formation Stimulation><Bone Regeneration><Bone Surface><Bone Tissue><CCCTC-binding factor><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CTCF protein><Cas nuclease technology><Cell Body><Cell Isolation><Cell Lineage><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Chromatin><Chromatin Structure><Chromosome Mapping><Chromosomes><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Competence><Complex><Control Groups><DNA-binding protein CTCF><Data Set><Development><Dimensions><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Female><Future><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Transcription><Genome><Genomic Segment><Genomics><Hi-C><Higher Order Chromatin Folding><Higher Order Chromatin Structure><Higher Order Structure><Histology><Impairment><Implant><In vivo analysis><Injections><Intervention><Intervention Strategies><Knowledge><Lamellar Bone><Link><Linkage Mapping><Maps><Mature Bone><Mediating><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mice><Mice Mammals><Micro RNA><MicroRNAs><Modeling><Modification><Molecular Interaction><Murine><Mus><Oophorectomy><Osteoblasts><Osteogenesis><Outcome><Ovariectomy><Phenotype><Preventative strategy><Prevention strategy><Preventive strategy><Progenitor Cells><Publishing><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Regulatory Element><Research><Resolution><Role><Selection Criteria><Specific qualifier value><Specified><Supporting Cell><Testing><Therapeutic><Time><Tissues><Total Human and Non-Human Gene Mapping><Transcription><Transcription Factor Proto-Oncogene><Transcription Regulation><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Transplantation><Undifferentiated><alkaline phosphomonoesterase><bone><bone loss><bone tissue formation><cell sorting><chromosomal location><chromosomal position><chromosome location><clinical relevance><clinically relevant><cohort><developmental><differential expression><differentially expressed><epigenetically><female gonadectomy><functional genomics><gene network><genetic mapping><genome segment><genomic region><glycerophosphatase><histone modification><in vivo><in vivo evaluation><in vivo testing><interventional strategy><male><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><miRNA><miRNAs><mouse model><murine model><novel><osteoblast cell differentiation><osteoblast differentiation><osteoblastic differentiation><osteogenic><programs><protein complex><regenerate bone><resolutions><skeletal disease><skeletal disorder><social role><stem cells><subcutaneous><subdermal><transcription factor><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><translational applications><transplant><treatment strategy>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Gary S. Stein

UNIVERSITY OF VERMONT & ST AGRIC COLLEGE, BURLINGTON, VT

Exploratory lead · 36/100
Likely hiring
Solid budget
$496,258
FY 2024

Project Title

Chromatin Organization Regulates Osteogenesis

Grant Number:

5R01DE029311-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/6/2020

End Date:

12/31/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY This new R01 builds on discoveries during the R37 period (2008-2018) that established epigenetic mechanisms (miRNAs, histone modifications) regulating osteoblast differentiation. We characterized for the first time a “signature” of specific histone modifications that are associated with dyna...

Research Terms

<Acetylation><Acute><Affect><Aging><Alkaline Phosphatase><Assay><Basal Transcription Factor><Basal transcription factor genes><Binding><Bioassay><Biological Assay><Body Tissues><Bone Development><Bone Formation><Bone Formation Stimulation><Bone Regeneration><Bone Surface><Bone Tissue><CCCTC-binding factor><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CTCF protein><Cas nuclease technology><Cell Body><Cell Isolation><Cell Lineage><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Chromatin><Chromatin Structure><Chromosome Mapping><Chromosomes><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Competence><Complex><Control Groups><DNA-binding protein CTCF><Data Set><Development><Dimensions><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Female><Future><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Transcription><Genome><Genomic Segment><Genomics><Hi-C><Higher Order Chromatin Folding><Higher Order Chromatin Structure><Higher Order Structure><Histology><Impairment><Implant><In vivo analysis><Injections><Intervention><Intervention Strategies><Knowledge><Lamellar Bone><Link><Linkage Mapping><Maps><Mature Bone><Mediating><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mice><Mice Mammals><Micro RNA><MicroRNAs><Modeling><Modification><Molecular Interaction><Murine><Mus><Oophorectomy><Osteoblasts><Osteogenesis><Outcome><Ovariectomy><Phenotype><Preventative strategy><Prevention strategy><Preventive strategy><Progenitor Cells><Publishing><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Regulatory Element><Research><Resolution><Role><Selection Criteria><Specific qualifier value><Specified><Supporting Cell><Testing><Therapeutic><Time><Tissues><Total Human and Non-Human Gene Mapping><Transcription><Transcription Factor Proto-Oncogene><Transcription Regulation><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Transplantation><Undifferentiated><alkaline phosphomonoesterase><bone><bone loss><bone tissue formation><cell sorting><chromosomal location><chromosomal position><chromosome location><clinical relevance><clinically relevant><cohort><developmental><differential expression><differentially expressed><epigenetically><female gonadectomy><functional genomics><gene network><genetic mapping><genome segment><genomic region><glycerophosphatase><histone modification><in vivo><in vivo evaluation><in vivo testing><interventional strategy><male><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><miRNA><miRNAs><mouse model><murine model><novel><osteoblast cell differentiation><osteoblast differentiation><osteoblastic differentiation><osteogenic><programs><protein complex><regenerate bone><resolutions><skeletal disease><skeletal disorder><social role><stem cells><subcutaneous><subdermal><transcription factor><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><translational applications><transplant><treatment strategy>
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Janet L Stein

UNIVERSITY OF VERMONT & ST AGRIC COLLEGE, BURLINGTON, VT

Exploratory lead · 36/100
Likely hiring
Solid budget
$496,258
FY 2024

Project Title

Chromatin Organization Regulates Osteogenesis

Grant Number:

5R01DE029311-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/6/2020

End Date:

12/31/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

SUMMARY This new R01 builds on discoveries during the R37 period (2008-2018) that established epigenetic mechanisms (miRNAs, histone modifications) regulating osteoblast differentiation. We characterized for the first time a “signature” of specific histone modifications that are associated with dyna...

Research Terms

<Acetylation><Acute><Affect><Aging><Alkaline Phosphatase><Assay><Basal Transcription Factor><Basal transcription factor genes><Binding><Bioassay><Biological Assay><Body Tissues><Bone Development><Bone Formation><Bone Formation Stimulation><Bone Regeneration><Bone Surface><Bone Tissue><CCCTC-binding factor><CRISPR><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas system><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CTCF protein><Cas nuclease technology><Cell Body><Cell Isolation><Cell Lineage><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Chromatin><Chromatin Structure><Chromosome Mapping><Chromosomes><Clustered Regularly Interspaced Short Palindromic Repeats><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Competence><Complex><Control Groups><DNA-binding protein CTCF><Data Set><Development><Dimensions><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Female><Future><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Regulation><Gene Regulation Process><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Transcription><Genome><Genomic Segment><Genomics><Hi-C><Higher Order Chromatin Folding><Higher Order Chromatin Structure><Higher Order Structure><Histology><Impairment><Implant><In vivo analysis><Injections><Intervention><Intervention Strategies><Knowledge><Lamellar Bone><Link><Linkage Mapping><Maps><Mature Bone><Mediating><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><Mice><Mice Mammals><Micro RNA><MicroRNAs><Modeling><Modification><Molecular Interaction><Murine><Mus><Oophorectomy><Osteoblasts><Osteogenesis><Outcome><Ovariectomy><Phenotype><Preventative strategy><Prevention strategy><Preventive strategy><Progenitor Cells><Publishing><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Regulatory Element><Research><Resolution><Role><Selection Criteria><Specific qualifier value><Specified><Supporting Cell><Testing><Therapeutic><Time><Tissues><Total Human and Non-Human Gene Mapping><Transcription><Transcription Factor Proto-Oncogene><Transcription Regulation><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Transplantation><Undifferentiated><alkaline phosphomonoesterase><bone><bone loss><bone tissue formation><cell sorting><chromosomal location><chromosomal position><chromosome location><clinical relevance><clinically relevant><cohort><developmental><differential expression><differentially expressed><epigenetically><female gonadectomy><functional genomics><gene network><genetic mapping><genome segment><genomic region><glycerophosphatase><histone modification><in vivo><in vivo evaluation><in vivo testing><interventional strategy><male><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><miRNA><miRNAs><mouse model><murine model><novel><osteoblast cell differentiation><osteoblast differentiation><osteoblastic differentiation><osteogenic><programs><protein complex><regenerate bone><resolutions><skeletal disease><skeletal disorder><social role><stem cells><subcutaneous><subdermal><transcription factor><transcriptional differences><transcriptome sequencing><transcriptomic sequencing><translational applications><transplant><treatment strategy>
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Carolyn Bertozzi

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 36/100
Likely hiring
Solid budget
$448,667
FY 2023

Project Title

Chemical Glycobiology Tool Development: LYTACs

Grant Number:

5R01GM058867-26

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/1999

End Date:

6/30/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY This is a renewal application of R37 GM058867 which has supported our foundational efforts in chemical glycobiology tool development since 1999. In the next granting period we will focus our efforts on a new chemical biology platform for targeted degradation of extracellular proteins...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><APF-1><ATP-Dependent Proteolysis Factor 1><Address><Affinity><Aging><Antibodies><Antigens><Autoimmune Diseases><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Binding><Biology><CIMPR><Cancers><Cell Body><Cell Surface Proteins><Cell Surface Receptors><Cell surface><Cells><Chemicals><Chemistry><Chimera><Chimera organism><Clinical Trials><Dendrimers><Dendritic Compounds><Dendrons><Destinations><Disease><Disorder><E3 Ligase><E3 Ubiquitin Ligase><Elements><Endosomes><Enzyme Gene><Enzymes><Exclusion><Extracellular Protein><Genes><Glycans><Glycobiology><Glycopeptides><Golgi><Golgi Apparatus><Golgi Complex><Grant><HMG-20><HPGF><Hepatocyte-Stimulating Factor><High Mobility Protein 20><Human><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IGF2R><IGF2R gene><IL-6><IL6 Protein><In Vitro><Insulin-Like Growth Factor 2 Receptor><Interleukin-6><Investments><Libraries><Ligand Binding><Ligands><Link><Lysosomes><MGI-2><MPRI><Macropain><Macroxyproteinase><Malignant Neoplasms><Malignant Tumor><Mannose 6-Phosphate Receptor, Cation-Independent><Medicine><Membrane><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Metabolic Protein Degradation><Mice><Mice Mammals><Modeling><Modern Man><Molecular Interaction><Multicatalytic Proteinase><Murine><Mus><Myeloid Differentiation-Inducing Protein><Organelles><Pathway interactions><Plasmacytoma Growth Factor><Polysaccharides><Position><Positioning Attribute><Prosome><Protac><Proteasome><Proteasome Endopeptidase Complex><Protein Turnover><Proteins><Proteolysis targeting chimeric><Proteome><Proteomics><Proteosome><Receptor Protein><Receptosomes><Regulatory Protein Degradation><Research><Site><Structure><Surface Proteins><System><Technology><Testing><Therapeutic><Ubiquitin><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Work><Xenograft Model><analog><autoimmune condition><autoimmune disorder><autoimmunity disease><biopharmaceutical company><biopharmaceutical industry><cellular targeting><chimeras><design><designing><extracellular><immunogen><in vivo><interest><interferon beta 2><malignancy><mannose 6 phosphate><membrane structure><multicatalytic endopeptidase complex><neoplasm/cancer><new approaches><new technology><novel approaches><novel strategies><novel strategy><novel technologies><pathway><programs><protein degradation><proteolysis targeting chimera><receptor><small molecule><therapeutic enzyme><tool><tool development><translational therapeutics><translational therapy><ubiquitin-protein ligase><xenograft transplant model><xenotransplant model>
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Gabor Balazsi

STATE UNIVERSITY NEW YORK STONY BROOK, STONY BROOK, NY

Exploratory lead · 36/100
Likely hiring
Active award
$232,900
FY 2021

Project Title

Administrative Supplement: Dynamics and evolution of synthetic and natural gene regulatory networks

Grant Number:

3R35GM122561-06S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2017

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary: Administrative Supplement to NIGMS MIRA R35GM122561 Parent project title: Dynamics and evolution of synthetic and natural gene regulatory networks This Administrative Supplement is based on NOT-GM-21-030, “Notice of Special Interest (NOSI): Administrative Supplements for Equipment P...

Research Terms

<Address><Administrative Supplement><Affect><Anti-microbial Drug Resistance><Anti-microbial Drug Resistant><Antimicrobial Drug Resistance><Antimicrobial Drug Resistant><Artificial Genes><Behavior><Biology><Biopsy><Biotech><Biotechnology><CRISPR><CRISPR/Cas system><Cancers><Cell Body><Cell Communication and Signaling><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Signaling><Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Complex><Computer Models><Computerized Models><Coupled><Engineering><Evolution><Expression Signature><Gene Expression Profile><Genes><Genetic><Genomics><Intracellular Communication and Signaling><Learning><Liquid substance><Malignant Neoplasms><Malignant Tumor><Microbial Drug Resistance><Modification><Molecular Fingerprinting><Molecular Profiling><NIGMS><National Institute of General Medical Sciences><Population><Proteomics><Regulator Genes><Signal Transduction><Signal Transduction Systems><Signaling><Synthetic Genes><System><Time><Transcriptional Regulatory Elements><base><biological signal transduction><cell sorting><computational modeling><computational models><computer based models><computerized modeling><equipment acquirement><equipment acquisition><equipment investment><equipment procurement><equipment purchase><equipment purchasing><fluid><gene expression pattern><gene expression signature><genetic payload><instrument acquisition><instrument investment><instrument procurement><instrument purchase><interest><liquid><malignancy><microbial drug resistant><molecular profile><molecular signature><neoplasm/cancer><parent grant><parent project><prevent><preventing><recombinase><regulatory gene><trans acting element><transcriptional profile><transcriptional signature><transcriptomics>
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David T Evans

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 34/100
Above-average budget
Active award
$754,576
FY 2026

Project Title

KIR and MHC Class I Immunogenetics in SIV Infection

Grant Number:

5R37AI095098-14

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/18/2023

End Date:

10/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Natural killer cells provide a critical early defense against viral pathogens by virtue of their ability to recognize and kill virus-infected cells without prior antigenic stimulation. This is accomplished through the integration of signals from killer-cell immunoglobulin-like receptors (KIRs) and C...

Research Terms

<AG2><AGR2><AGR2 gene><AIDS Virus><AIDS/HIV><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Activated Natural Killer Cell><Acute><Address><Affect><Alleles><Allelomorphs><Amino Acid Substitution><Animal Model><Animal Models and Related Studies><Animals><Anterior Gradient 2 Homolog><Antibodies><Antigenic Determinants><Avidity><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Binding><Binding Determinants><C Type Lectin Receptors><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cells><Chronic Phase><Class I Genes><Cloning><Communicable Diseases><Cross Reactions><Cytotoxic cell><DNA mutation><Data><Disease Progression><Epitopes><Fc Receptor><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Foundations><GOB-4><Genes><Genetic Change><Genetic Polymorphism><Genetic defect><Genetic mutation><Genome><HAG-2><HAG-2 Gene><HIV><HIV Infections><HIV viral infection><HIV virus infection><HIV-1><HIV-1 infection><HIV-I><HIV/AIDS><HIV1><Human><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Ig Genes><Immune Evasion><Immune Globulins><Immunize><Immunochemical Immunologic><Immunogenetics><Immunoglobulin Genes><Immunoglobulins><Immunologic><Immunological><Immunologically><Immunologics><Individual><Infection><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Infectious Diseases><Infectious Disorder><Instruction><Intracellular Communication and Signaling><Investigation><K Cells><K lymphocyte><Killer Cells><Knowledge><LAV-HTLV-III><Lectin Receptors><Ligands><Lymphadenopathy-Associated Virus><M mulatta><M. mulatta><MHC Class I><MHC Class I Genes><MHC Receptor><MHC binding peptide><Macaca><Macaca mulatta><Macaca rhesus><Macaque><Major Histocompatibility Complex Receptor><Memory><Methods><Modern Man><Molecular Interaction><Monitor><Mutation><NHP models><NK Cells><NK cell immune therapy><NK cell immunotherapy><NK cell therapy><NK cell treatment><NK cell-based immune therapy><NK cell-based immunotherapy><NK cell-based therapy><NK cell-based treatment><NK cellular immunotherapy><NK cellular therapy><NK immunotherapy><NK therapy><NK treatment><Natural Killer Cell Immunotherapy><Natural Killer Cells><Outcome><Peptides><Persons><Phenotype><Primates><Primates Mammals><Property><Proteins><Reagent><Receptor Cell><Receptor Gene><Receptor Protein><Recombinants><Rhesus Macaque><Rhesus Monkey><Role><SIV><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Simian Immunodeficiency Viruses><Sorting><Staining method><Stains><T-Cell Antigen Receptors><T-Cell Receptor><T4 Cells><T4 Lymphocytes><Testing><Viral><Viral Burden><Viral Diseases><Viral Load><Viral Load result><Virus><Virus Diseases><Virus-HIV><XAG-2><XAG-2 Gene><antibody receptor><biological signal transduction><cellular differentiation><flow cytophotometry><genome mutation><human immunodeficiency virus infection><hypoimmunity><immune deficiency><immune evasive><immunodeficiency><in vivo><infected with HIV><infected with human immunodeficiency virus><investigate longitudinal><longitudinal investigation><longitudinal research><model of animal><natural killer cell based immune therapy><natural killer cell based immunotherapy><natural killer cell therapy><natural killer cell treatment><natural killer cell-based therapy><natural killer cellular therapy><natural killer therapy><nonhuman primate models><novel><pathogenic virus><polymorphism><receptor><response><social role><study longitudinal><success><survey longitudinal><viral infection><viral pathogen><virus infection><virus pathogen><virus-induced disease>
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Leopoldo Nicolas Segal

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Exploratory lead · 34/100
Above-average budget
Active award
$652,880
FY 2026

Project Title

Local microbiota signatures of pro-tumor immunity and checkpoint inhibition susceptibility in lung cancer

Grant Number:

5R37CA244775-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract. PD-1 blockade has become first line therapy of most non-small cell lung cancer (NSCLC). However, given the variable effectiveness of immunotherapy in this disease there is a need to better understand factors that affect individual’s response to this therapy. The lung microbiota plays an im...

Research Terms

<1-Phosphatidylinositol 3-Kinase><16S RNA sequencing><16S RNAseq><16S gene sequencing><16S rDNA amplicon sequencing><16S rRNA DNA sequencing><16S rRNA amplicon sequencing><16S rRNA gene amplicon sequencing><16S rRNA gene sequencing><16S rRNA genomic profiling><16S rRNA sequencing><16S ribosomal RNA gene sequencing><16S ribosomal RNA sequencing><16S seq><16S sequencing><16s rRNA seq><Affect><Airway Disease><B7-H1><Biological Markers><Blood><Blood Plasma><Blood Reticuloendothelial System><CD274><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cancer Model><Cancer Patient><CancerModel><Cancers><Causality><Cell Body><Cells><Characteristics><Clinical><Clinical Trials><Color><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Data><Disease><Disorder><Distant><Early identification><Effectiveness><Eligibility><Eligibility Determination><Environment><Etiology><Evaluation><Feces><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><GI microbiome><GI microbiota><Gastrointestinal microbiota><General Taxonomy><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immune><Immune mediated therapy><Immune response><Immunes><Immunity><Immunologically Directed Therapy><Immunomodulation><Immunotherapy><Inflammation><Inflammatory><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Intervention><Investigation><Link><LoxP-flanked allele><Lung><Lung Adenocarcinoma><Lung Respiratory System><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mediating><Metabolic><Methods><Mice><Mice Mammals><Microbe><Microbiomics><Modeling><Modification><Murine><Mus><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Newly Diagnosed><Non-Polyadenylated RNA><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><Outcome><PD 1><PD-1><PD-L1><PD1><PDL-1><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><Parents><Pathway interactions><Patients><Phenotype><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Plasma><Plasma Serum><Play><Pre-Clinical Model><Preclinical Models><Predisposition><Prevalence><Prevotella><Programmed Cell Death 1 Ligand 1><Programmed Death Ligand 1><Progression-Free Survivals><Protocol Screening><PtdIns 3-Kinase><Pulmonary Cancer><Pulmonary malignant Neoplasm><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Reticuloendothelial System, Serum, Plasma><Ribonucleic Acid><Ribosomal RNA><Ribosomal RNA Genes><Role><Sampling><Susceptibility><T cell response><T-Cells><T-Lymphocyte><Taxonomy><Testing><Tumor Burden><Tumor Immunity><Tumor Load><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><Validation><Veillonella><airway microbial community><airway microbiome><airway microbiota><anti-tumor immune response><anti-tumor immunity><antitumor immunity><aspirate><bio-markers><biologic marker><biomarker><cancer immunity><cancer microenvironment><causation><check point inhibition><checkpoint inhibition><clinical relevance><clinically relevant><design><designing><digestive tract microbiome><disease causation><dysbacteriosis><dysbiosis><dysbiotic><enteric microbial community><enteric microbiome><enteric microbiota><flow cytophotometry><floxed><floxed allele><gastrointestinal microbial flora><gastrointestinal microbiome><global gene expression><global transcription profile><gut community><gut flora><gut lung communication><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><gut-lung axis><host response><immune check point><immune check point inhibition><immune checkpoint><immune checkpoint inhibition><immune modulation><immune regulation><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immunecheckpoint><immuno therapy><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><individual response><individualized response><individualized therapeutic><innovate><innovation><innovative><intestinal biome><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><lung cancer><lung carcinogenesis><lung microbial community><lung microbiota><malignancy><metabolism measurement><metabolomics><metabonomics><metatranscriptome><metatranscriptomics><microbial><microbial consortia><microbial flora><microbial imbalance><microbial signature><microbiome><microbiome research><microbiome science><microbiome studies><microbiota><microbiota patterns><microbiota profiles><microbiota signature><microflora><mortality><mouse model><mucosa-associated microbes><mucosa-associated microbial community><mucosa-associated microbiota><mucosal flora><mucosal microbes><mucosal microbiota><mucosal microflora><multiomics><multiple omics><multispecies consortia><murine model><neo-antigen><neo-epitopes><neoantigens><neoepitopes><neoplasm/cancer><novel><oral commensal><panomics><parent><pathway><personalized therapeutic><pre-clinical><preclinical><predict responsiveness><predicting response><primary outcome><programmed cell death 1><programmed cell death ligand 1><programmed cell death protein 1><programmed cell death protein ligand 1><programmed death 1><prospective><protein death-ligand 1><pulmonary><pulmonary microbial community><pulmonary microbiota><rRNA><rRNA Genes><respiratory microbiome><respiratory microbiota><respiratory tract microbiome><response><response to therapy><response to treatment><risk stratification><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><sle2><social role><stool><stratify risk><systemic lupus erythematosus susceptibility 2><therapeutic outcome><therapeutic response><therapy outcome><therapy responders><therapy response><thymus derived lymphocyte><trait><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><treatment responders><treatment response><treatment responsiveness><tumor><tumor microenvironment><validations>
View Full Project Details on NIH Reporter
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David A Fidock

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 34/100
Above-average budget
Active award
$546,798
FY 2026

Project Title

Defining the Role of PfCRT and PfMDR1 as Pleiotropic Mediators of Plasmodium falciparum Multidrug Resistance

Grant Number:

5R37AI050234-24

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2001

End Date:

1/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY (See instructions): Antimalarial drug resistance has repeatedly thwarted global efforts to treat and control malaria. Chloroquine, the former gold-standard drug, earlier succumbed to parasite strains harboring mutations in the Plasmodium falciparum chloroquine resistance transporter,...

Research Terms

<21+ years old><ABC Transport Protein><ABC Transporter Protein><ABC Transporters><ATP-Binding Cassette Transporters><Adult><Adult Human><Affinity><Africa><African><Amodiaquin><Amodiaquine><Anti-malarial drug resistance><Anti-malarial drug resistant><Anti-malarials><Anti-microbial Drug Resistance><Anti-microbial Drug Resistant><Antimicrobial Drug Resistance><Antimicrobial Drug Resistant><Area><Artemisinins><Asian><Assay><Automobile Driving><Binding><Binding Proteins><Bioassay><Biological><Biological Assay><Biological Markers><Biophysics><Cambodia><Cambodian><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Culture Techniques><Cells><Chemistry><Chemoprevention><Chlorochin><Chloroquine><Chloroquine resistance><Chromosome 12><Chromosome 7><Chromosome Mapping><Collaborations><Combined Modality Therapy><Coupled><Cryo-electron Microscopy><Cryoelectron Microscopy><DNA mutation><Data><Drug Efflux><Drug Targeting><Drug Transport><Drug resistance><Drugs><Electron Cryomicroscopy><Epistasis><Epistatic Deviation><Eukaryotic Cell><Funding><Gene Localization><Gene Mapping><Gene Mapping Genetics><Generalized Growth><Genes><Genetic Change><Genetic Crosses><Genetic Determinism><Genetic Epistasis><Genetic Population Study><Genetic defect><Genetic mutation><Genomics><Goals><Growth><Infection><Instruction><Interaction Deviation><Investigation><Isoforms><Kampuchea><Khingamin><Khmer Republic><Licensing><Ligand Binding Protein><Ligand Binding Protein Gene><Linkage Disequilibrium><Linkage Mapping><Malaria><Maps><Measurement><Mediating><Mediator><Medication><Mefloquine><Microbial Drug Resistance><Molecular Interaction><Multi-Drug Resistance><Multidrug Resistance><Multimodal Therapy><Multimodal Treatment><Multiple Drug Resistance><Multiple Drug Resistant><Mutation><NIAID><National Institute of Allergy and Infectious Disease><Nature><P falciparum><P. falciparum><P.falciparum><Paludism><Parasite resistance><Parasites><Patients><PfCRT protein><Pharmaceutical Preparations><Phenotype><Physiologic><Physiological><Plasmodium Infections><Plasmodium falciparum><Play><Predisposition><Property><Protein Binding><Protein Isoforms><Proxy><Publishing><QTL><Quantitative Trait Loci><Quinine><Radiolabeled><Recombinant Proteins><Recombinants><Reporting><Research><Research Design><Research Support><Resistance><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistant to Multiple Drug><Resistant to multi-drug><Resistant to multidrug><Risk><Role><Seasons><Source><Southeast Asia><Southeastern Asia><Structure><Study Type><Susceptibility><System><Testing><Therapeutic Intervention><Tissue Growth><Total Human and Non-Human Gene Mapping><Transmission><Treatment Failure><Vacuole><Variant><Variation><acquired immunity><adulthood><anti-malarial agents><anti-malarial drugs><anti-malarial resistance><arteannuin><artemisinine><benflumetol><bio-markers><biologic><biologic marker><biomarker><biophysical foundation><biophysical principles><biophysical sciences><bound protein><cell culture><cell cultures><chemical library><chloroquine resistant><combination therapy><combined modality treatment><combined treatment><cost><cryo-EM><cryoEM><cryogenic electron microscopy><driving><drug action><drug efficacy><drug resistant><drug standard><drug-sensitive><drug/agent><entire genome><epistatic interaction><epistatic relationship><evidence base><fitness><full genome><gene x gene interaction><genetic association><genetic determinant><genetic epistases><genetic mapping><genome mutation><genome sequencing><humanized mice><humanized mouse><inhibitor><insight><intervention therapy><knock-down><knockdown><lumefantrine><microbial drug resistant><mouse model><multi-drug resistant><multi-modal therapy><multi-modal treatment><multidrug resistant><murine model><mutant><nano-molar><nanomolar><novel><ontogeny><overexpress><overexpression><parasite resistant><pharmacologic><prevent><preventing><programs><protein purification><pyronaridine><qinghaosu><quing hau sau><quinghaosu><radiolabeling><radiologically labeled><resistance allele><resistance in parasite><resistance mutation><resistance to Drug><resistance to Parasite><resistance to anti-malarial drug><resistance to chloroquine><resistant><resistant allele><resistant mutation><resistant parasite><resistant to Drug><resistant to Parasite><resistant to anti-malarial drug><resistant to chloroquine><segregation><small molecule libraries><social role><study design><success><therapy failure><transmission process><whole genome>
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Chang-il Hwang

UNIVERSITY OF CALIFORNIA AT DAVIS, DAVIS, CA

Exploratory lead · 32/100
Solid budget
Recent
Active award
$357,267
FY 2026

Project Title

Engrailed-1 and Epigenetic Vulnerabilities in Metastatic Pancreatic Cancer

Grant Number:

4R37CA249007-06

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2028

Project Abstract

Abstract Pancreatic ductal adenocarcinoma (PDA) is one of the most lethal cancers, largely due to its aggressive nature and resistance to therapies. Our research focuses on the transcription factor EN1, a key regulator of the epigenome in PDA. During the R37 grant period, we made significant progres...

Research Terms

<Abbreviations><Acceleration><Address><Alleles><Allelomorphs><Architecture><Automobile Driving><BS-seq><Basal Transcription Factor><Basal transcription factor genes><Biological Mimetics><Biomimetics><Biopsy><Bisulfite-based sequencing><Blood Vessels><California><Cancers><ChIP Sequencing><ChIP assay><ChIP-seq><ChIPseq><Chromatin><Co-Immunoprecipitations><Co-culture><Cocultivation><Coculture><Coculture Techniques><Comprehensive Cancer Center><DNA Methylation><Data><Data Analyses><Data Analysis><Development><Disease Progression><Disseminated Malignant Neoplasm><ENX-1><EZH1><EZH2><EZH2 gene><Endometrial Cancer><Endometrial Carcinoma><Endometrium Cancer><Endometrium Carcinoma><Engineering / Architecture><Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit><Enhancers><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelium><GEM model><GEMM model><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Gene set enrichment analysis><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Transcription><Genetically Engineered Mouse><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioma><Grant><Hi-C><Human><In Vitro><Injections><Invaded><Investigation><KMT6><KMT6A><Kidney Cancer><Kidney Carcinoma><Lung><Lung Respiratory System><Malignant Cell><Malignant Neoplasms><Malignant Ovarian Neoplasm><Malignant Ovarian Tumor><Malignant Pancreatic Neoplasm><Malignant Tumor><Malignant Tumor of the Ovary><Malignant neoplasm of ovary><Malignant neoplasm of pancreas><Mediating><Mesenchymal><Metastasis><Metastasize><Metastatic Cancer><Metastatic Lesion><Metastatic Malignant Neoplasm><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><NGS Method><NGS system><Nature><Neoplasm Metastasis><Neuroglial Neoplasm><Neuroglial Tumor><Organoids><Outcome Study><Ovary Cancer><PDA model><PDAC Model><PDX model><PanIN><Pancreas><Pancreas Cancer><Pancreas Ductal Adenocarcinoma><Pancreatic><Pancreatic Cancer><Pancreatic Duct Dysplasia><Pancreatic Ductal Adenocarcinoma><Pancreatic Ductal Dysplasia><Pancreatic Intraepithelial Neoplasia><Pathway interactions><Patient derived xenograft><Patients><Process><Prognosis><Property><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Renal Cancer><Renal Carcinoma><Research><Resected><Resistance><Role><Sampling><Secondary Neoplasm><Secondary Tumor><Solid Neoplasm><Solid Tumor><Stomach><Structure><Surgical Models><System><TCGA><Tail><Testing><The Cancer Genome Atlas><Therapeutic><Therapeutic Intervention><Thyroid><Thyroid Gland><Thyroid Head and Neck><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Tumor-Derived><Universities><Urothelium><Veins><bisulfite sequencing><bisulfite-seq><cancer cell><cancer metastasis><cancer progression><cancer type><chromatin immunoprecipitation><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><chromatin remodeling><conditional knock-out><conditional knockout><data interpretation><developmental><driving><effective therapy><effective treatment><epigenetically><epigenome><experiment><experimental research><experimental study><experiments><expression subtypes><gain of function><gastric><genetically engineered mouse model><genetically engineered murine model><glial-derived tumor><improved><in vivo><insight><intervention therapy><loss of function><malignancy><molecular sub-types><molecular subsets><molecular subtypes><mouse model><murine model><neoplasm progression><neoplasm/cancer><neoplastic progression><neuroglia neoplasm><neuroglia tumor><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><next gen sequencing><next generation sequencing><nextgen sequencing><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><ovarian cancer><pancreas duct dysplasia><pancreas ductal dysplasia><pancreatic cancer patients><pancreatic ductal adenocarcinoma model><pancreatic malignancy><pathway><patient derived xenograft model><patients with pancreatic cancer><pharmacologic><promoter><promotor><resistance to therapy><resistant><resistant to therapy><response to therapy><response to treatment><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><therapeutic resistance><therapeutic response><therapy resistant><therapy response><trait><transcription factor><transcriptome sequencing><transcriptomic sequencing><transcriptomics><transplant model><treatment resistance><treatment response><treatment responsiveness><tumor><tumor cell metastasis><tumor progression><vascular>
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Edward T. Ryan

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 30/100
Very recent
Active award
$123,400
FY 2026

Project Title

O-Specific Polysaccharide Responses and Cholera

Grant Number:

3R37AI106878-12S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2030

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Cholera is a severe dehydrating illness of humans. It is endemic in over 50 countries and causes 3 to 5 million cases a year, resulting in approximately 100,000 deaths. Currently available cholera vaccines are poorly immunogenic in children under the age of 5 years, and often do not induce robust lo...

Research Terms

<0-11 years old><19S Gamma Globulin><21+ years old><5 year old><5 years of age><7S Gamma Globulin><Ab-mediated immunity><Ab-mediated protection><Address><Adult><Adult Human><Affect><Affinity><Animals><Antibodies><Antibody immunity><Antibody protection><Antibody-mediated protection><Antigens><B-cell receptor repertoire sequencing><B-cell receptor sequencing><BCR repertoire sequencing><BCR seq><BCR sequencing><BCRseq><Bacterial O Antigen><Bangladesh><Body Tissues><Cell Body><Cells><Cessation of life><Child><Child Youth><Children (0-21)><Cholera><Cholera Vaccine><Clinical Treatment Moab><Country><Data><Death><Dehydration><Development><ELISPOT><Endoscopic Biopsy><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Gene Expression><Gene Transcription><Genetic Transcription><Genomics><Goals><Household><Human><IgA><IgG><IgM><Immune><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunoglobulin A><Immunoglobulin G><Immunoglobulin M><Immunologic><Immunological><Immunologically><Immunologics><Immunology><Infection with V cholerae><Infection with V. cholerae><Infection with Vibrio cholerae><Instruction><International><Intestinal><Intestines><Knowledge><MHC Receptor><Major Histocompatibility Complex Receptor><Mediating><Methods><Microbe><Microbiology><Modeling><Modern Man><Monoclonal Antibodies><Motility><Mucins><Mucosa><Mucosal Tissue><Mucous Membrane><Mucus Glycoprotein><O Antigens><O-Specific Polysaccharides><Oral><Organoids><Patients><Peer Review><Penetration><Peripheral><Population><Position><Positioning Attribute><Process><Productivity><Proteomics><Protocol><Protocols documentation><Publications><RNA Expression><Reagent><Research><Research Resources><Resources><Sampling><Scientific Publication><Serology><Single-Nucleus Sequencing><Surface><System><T-Cell Antigen Receptors><T-Cell Receptor><Tissue Sample><Tissues><Toxin><Transcription><V cholerae><V cholerae O1><V cholerae Serogroup O1><V cholerae infection><V. cholerae><V. cholerae O1><V. cholerae Serogroup O1><V. cholerae infection><Vaccines><Vibrio cholerae><Vibrio cholerae O1><Vibrio cholerae Serogroup O1><Vibrio cholerae infection><Vibrio comma><Work><adulthood><age 5><age 5 years><antibody-mediated immunity><biological sex><body water dehydration><bowel><cholera infection><complement deficiency><defined contribution><developmental><diarrheal disease><diarrheal illness><enzyme linked immunospot assay><experience><five year old><five years of age><flow cytophotometry><holotoxins><host response><human subject><immune system response><immunization strategy><immunogen><immunogenic><immunoresponse><improved><infected with cholera><infection with cholera><international center><intestinal epithelium><kids><long-term memory><mAbs><monoclonal Abs><mouse model><murine model><next generation><pathogen><peripheral blood><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><programs><response><sNuc-Seq><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><sound><success><vaccination strategy><vaccine strategy><youngster>
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Beatrice H Hahn

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 28/100
Above-average budget
Active award
$865,153
FY 2025

Project Title

Optimizing glycan shield coverage, germline B cell receptor binding and epitope diversity of V2-apex targeted HIV-1 Env immunogens

Grant Number:

5R37AI150590-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/19/2019

End Date:

8/31/2029

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY (See instructions): A central goal in HIV/AIDS vaccine research is the elicitation of broadly neutralizing antibodies (bNAbs). Here, we leverage three recent discoveries from our groups to generate more effective V2 apex immunogens. Having found that unshielded regions (“glycan hol...

Research Terms

<AIDS Virus><Ab-mediated immunity><Ab-mediated protection><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Affinity><Animal Model><Animal Models and Related Studies><Animals><Antibodies><Antibody Response><Antibody immunity><Antibody protection><Antibody-mediated protection><Antigenic Determinants><Antigens><Apical><Autologous><B blood cells><B cell><B cells><B-Cell Receptor Binding><B-Cells><B-Lymphocytes><B-cell><Binding><Binding Determinants><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><COVID-19><CV-19><Cell Lineage><Characteristics><Clinical Treatment Moab><Coronavirus Infectious Disease 2019><Data><Development><Dose><Epitopes><Event><Evolution><Genes><Germ Lines><Glycans><Goals><HIV><HIV vaccine><HIV-1><HIV-1 vaccine><HIV-I><HIV/AIDS Vaccines><HIV1><HIV1 vaccine><Human><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Immunization><Immunize><Instruction><LAV-HTLV-III><Lineage Tracing><Lymphadenopathy-Associated Virus><M mulatta><M. mulatta><Macaca><Macaca mulatta><Macaca rhesus><Macaque><Maps><Masks><Membrane><Messenger RNA><Modern Man><Molecular Interaction><Monkeys><Monoclonal Antibodies><Nucleosides><Paper><Pathway interactions><Pattern><Polysaccharides><Post-vaccination infection><Primates><Primates Mammals><Productivity><Property><Publishing><Regimen><Reproducibility><Rhesus><Rhesus Macaque><Rhesus Monkey><SHIV><T4 Cells><T4 Lymphocytes><Testing><Translating><Transmission><Vaccination><Vaccine Design><Vaccine Research><Vaccines><Variant><Variation><Virus><Virus-HIV><Work><antibody-mediated immunity><bio-informatics tool><bioinformatics tool><booster dose><booster shot><booster vaccine><breakthrough infection><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><challenge in rhesus macaques><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><design><designing><develop a vaccine><develop vaccines><development of a vaccine><developmental><env Glycoproteins><human immunodeficiency virus vaccine><immunogen><immunogenicity><improved><in vivo><infected rhesus macaques><infected rhesus monkey><infection in rhesus macaques><infection of rhesus macaques><lipid based nanoparticle><lipid nanoparticle><mAbs><mRNA><member><membrane structure><model of animal><monoclonal Abs><neutralizing antibody><neutralizing mAb><neutralizing monoclonal antibodies><novel><pathway><pre-clinical><preclinical><protective efficacy><rational design><response><rhesus challenge><rhesus macaque challenge><rhesus monkey infection><simian HIV><simian human immunodeficiency virus><transmission process><vaccine boost><vaccine development><vaccine-related research><vector>
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Alan N. Engelman

DANA-FARBER CANCER INST, BOSTON, MA

Exploratory lead · 28/100
Above-average budget
Active award
$819,601
FY 2025

Project Title

Biochemical Mechanism of HIV DNA Integration

Grant Number:

4R37AI039394-30

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

5/31/2030

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

HIV-1 remains a significant health problem. In 2022, 1.3 million people became infected globally, and 0.63 million people died from AIDS. 39 million people currently live with HIV. We still lack effective vaccine and cure strategies. Antiretroviral inhibitors, which mainly target HIV-1 enzyme activi...

Research Terms

<3-D structure><3-dimensional structure><3D structure><AIDS><AIDS Virus><AIDS/HIV><AT Hooks><AT-Hook Motifs><ATH><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Anti-Retroviral Agents><Binding><Binding Proteins><Biochemical><Black><Black race><C-terminal><Capsid><Catalysis><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Charge><Chromatin><Chromosomes><Code><Coding System><Complex><Crystallins><DNA><DNA Binding><DNA Binding Interaction><DNA Integration><DNA bound><Deoxyribonucleic Acid><Development><Dimerization><Drug Prescribing><Drug Prescriptions><Drugs><Elements><Enzyme Gene><Enzymes><Future><Gene Transcription><Generations><Genes><Genetic Transcription><Grant><H-bond><HIV><HIV-1><HIV-I><HIV/AIDS><HIV1><Health><Host Factor><Host Factor Protein><Human><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Hydrogen Bonding><Individual><Infection><Instruction><Integrase><Integrase Inhibitors><Integration Host Factors><LAV-HTLV-III><Left><Ligand Binding Protein><Ligand Binding Protein Gene><Lymphadenopathy-Associated Virus><Medication><Modern Man><Molecular><Molecular Interaction><Morphogenesis><Morphology><N Domain><N-terminal><NH2-terminal><NLS Peptide><Nature><Non-Polyadenylated RNA><Nuclear><Nuclear Localization Signal><Nuclear Localization Signal Peptide><Nucleosides><Pathogenesis><Pathway interactions><Patients><Pattern><Persons><Pharmaceutical Preparations><Phase 2 Clinical Trials><Phase II Clinical Trials><Physiologic><Physiological><Polymers><Position><Positioning Attribute><Protein Binding><Protein Dimerization><Proteins><Protomer><RNA><RNA Binding><RNA Expression><RNA Gene Products><RNA bound><Regimen><Resolution><Retroviridae><Retroviruses><Reverse Transcriptase Inhibitors><Reverse Transcription><Ribonucleic Acid><Roentgen Rays><Role><Seminal><Spinal Column><Spine><Structure><Tail><Text><Transcript><Transcription><Trp-Pro><Vaccines><Vertebral column><Viral><Virion><Virus><Virus Inhibitors><Virus Integration><Virus Particle><Virus-HIV><Virus-Retrovirus><Work><X-Radiation><X-Ray Radiation><X-ray><Xray><alpha helix><anti-retroviral><backbone><bound protein><developmental><dimer><drug development><drug/agent><enzyme activity><flexibility><flexible><improved><inhibitor><lens epithelium-derived growth factor><lens protein><medication prescription><mimicry><morphogenetic process><novel><p75><p75 transcription factor><pandemic><pandemic disease><particle><pathway><pharmacologic><phase II protocol><polymer><polymeric><polymerization><prescribed medication><resolutions><small molecular inhibitor><small molecule inhibitor><social role><three dimensional structure><transcriptional coactivator p75><tryptophyl-proline><viral DNA><viral RNA><viral genome integration><viral inhibitor><viral integration><virus DNA><virus RNA><virus genome integration><α-helix>
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Michaela R. Reagan

MAINEHEALTH, PORTLAND, ME

Exploratory lead · 28/100
Above-average budget
Active award
$786,900
FY 2025

Project Title

Defining the Roles of Bone Marrow Adipocytes and FABP4/5 Signaling in Multiple Myeloma Drug Resistance

Grant Number:

4R37CA245330-06

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

6/30/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

ABSTRACT – MERIT EXTENSION The overall goal of this MERIT Extension research project is to support the original goals of our parent grant and build logically on our findings, while staying within the scope of the parent grant. My parental R37 focuses on examining how fatty acid-binding proteins (FAB...

Research Terms

<1-Phosphatidylinositol 3-Kinase><21+ years old><3-D><3-Dimensional><3D><A-FABP><Address><Adipocytes><Adipose Cell><Adipose tissue><Adult><Adult Human><Aging><Autocrine Systems><Automobile Driving><B cell tumor><B-Cell Differentiation Factor Gene><B-Cell Lymphocytic Neoplasm><B-Cell Neoplasm><B-Cell Stimulatory Factor 2 Gene><B-lineage tumor><BSF-2 Gene><BSF2 Gene><Beta-2 Gene Interferon><Biological><Blood><Blood Plasma Cell><Blood Reticuloendothelial System><Blood Serum><Body Tissues><Bone Diseases><Bone Marrow><Bone Marrow Blood-Deriving Cell><Bone Marrow Blood-Forming Cell><Bone Marrow Cells><Bone Marrow Reticuloendothelial System><Cancer Model><CancerModel><Cancers><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Signaling><Cell Survival><Cell Viability><Cells><Cellular Expansion><Cellular Growth><Cellular Proliferation><Clinical><Co-culture><Cocultivation><Coculture><Coculture Techniques><Compensation><DNA mutation><Data><Development><Dimensions><Disease Progression><Disease Resistance><Drug Therapy><Drug resistance><E-FABP><Energy Expenditure><Energy Metabolism><Energy-Generating Resources><Exhibits><Exposure to><Extracellular Signal-Regulated Kinase Gene><FABP4><FABP4 gene><FABP5><FABP5 gene><Fat Cells><Fatty Acid Binding Protein 4, Adipocyte><Fatty Acids><Fatty Tissue><Fracture><Free Fatty Acids><Gene Expression><Generalized Growth><Generations><Genes><Genetic><Genetic Change><Genetic Models><Genetic defect><Genetic mutation><Goals><Growth><HSF Gene><HUMPPARG><Hematopoietic Cell Tumor><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Hepatocyte Stimulatory Factor Gene><High Fat Diet><Homing><Human><Hybridoma Growth Factor Gene><IFNB2 Gene><IL-6 Gene><IL6><IL6 gene><In Vitro><Individual><Interleukin 6 (Interferon, Beta 2) Gene><Interleukin-6 Gene><Intervention><Intracellular Communication and Signaling><KFABP><Knock-out><Knockout><Lab Findings><Laboratory Finding><Lipids><Lipocytes><MAP Kinase Gene><MAPK><Malignant><Malignant - descriptor><Malignant Cell><Malignant Hematopoietic Neoplasm><Malignant Neoplasms><Malignant Tumor><Mature Lipocyte><Mature fat cell><Mediator><Messenger RNA><Methods><Mice><Mice Mammals><Mitogen-Activated Protein Kinase Gene><Modeling><Modern Man><Multiple Myeloma><Murine><Mus><Mutation><NR1C3><Nonesterified Fatty Acids><Obesity><Oral Administration><Oral Drug Administration><Osteolysis><Osteoporosis><PA-FABP><PI-3 Kinase><PI-3K/AKT><PI3-Kinase><PI3CG><PI3K/AKT><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><PPARG><PPARG gene><PPARG1><PPARG2><Pathway interactions><Patients><Pattern><Pharmacological Treatment><Pharmacotherapy><Phenotype><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Plasma Cells><Plasma-Cell Myeloma><Plasmacytes><Process><Proliferating><Proteins><PtdIns 3-Kinase><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Project Grants><Research Projects><Research Resources><Resources><Risk Factors><Role><Serum><Signal Induction><Signal Transduction><Signal Transduction Systems><Signaling><Soil><Testing><Tissue Engineering><Tissue Growth><Tissue Model><Tissues><Tumor Cell><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><Work><adipocytokines><adipokines><adipose><adiposity><adulthood><autocrine><bioengineered tissue><biologic><biological signal transduction><blood cancer><bone><bone disorder><bone fracture><cancer cell><cancer drug resistance><cancer of blood><cancer of the blood><cell growth><corpulence><develop drug resistance><developmental><dietary><driving><drug development><drug intervention><drug resistance development><drug resistant><drug treatment><energy source><engineered tissue><experience><fat metabolism><fatty acid-binding proteins><genome mutation><immune microenvironment><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><improved><in vivo><in vivo Model><inhibitor><instrument><intraoral drug delivery><knock-down><knockdown><lipid metabolism><mRNA><malignancy><member><mouse model><murine model><myeloma><myelomatosis><neoplasm/cancer><neoplastic cell><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><ontogeny><paracrine><parent award><parent grant><parent project><pathway><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><physiologic model><plasmocyte><prevent><preventing><protein expression><resistance mechanism><resistance to Drug><resistance to cancer drugs><resistance to disease><resistance to therapy><resistant disease><resistant mechanism><resistant to Drug><resistant to cancer drugs><resistant to disease><resistant to therapy><response><social role><survival outcome><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic resistance><therapy resistant><three dimensional><treatment resistance><tumor><tumor growth><tumor immune microenvironment><tumor-immune system interactions><uptake><white adipose tissue><yellow adipose tissue>
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Stephany Yi Tzeng

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 28/100
Above-average budget
Active award
$749,156
FY 2025

Project Title

A Platform Technology to Genetically Reprogram Cancer Cells for Enhanced Immunotherapy

Grant Number:

4R37CA246699-06

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

6/30/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Advances in cancer immunotherapy have great potential for treating tumors that are refractory to conventional treatments, and T cells primed ex vivo by natural or artificial antigen-presenting cells (APCs) to target and kill cancer cells have been shown clinically to improve surviva...

Research Terms

<4T1><Activated Natural Killer Cell><Antigen-Presenting Cells><Antigens><Antitumor Response><Artificial nano particles><Artificial nanoparticles><B16F10><B7-1><B7-H1><BB1><Biological><Blood group antigen S><Body Tissues><CD134L><CD274><CD28LG><CD28LG1><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD80><CD80 gene><Cancer Model><CancerModel><Cancers><Cell Body><Cell Communication and Signaling><Cell Reprogramming><Cell Signaling><Cell-Mediated Lympholytic Cells><Cells><Cellular Expansion><Cellular Growth><Cellular immunotherapy><Checkpoint inhibitor><Circulation><Clinic><Clinical><Co-Stimulator><Co-culture><Cocultivation><Coculture><Coculture Techniques><Complex><Costimulator><Cytolytic T-Cell><Cytotoxic T Cell><Cytotoxic T-Lymphocytes><Cytotoxic cell><DNA><DNA Therapy><DNA cassette><DNA delivery><Deoxyribonucleic Acid><Development><Disseminated Malignant Neoplasm><Distant><Edodekin Alfa><Engineering><Epidermal Thymocyte Activating Factor><Esters><Formulation><GP34><Gene Expression><Gene Transfer Clinical><Genes><Genetic><Genetic Intervention><Goals><Grant><Histocompatibility Complex><Histocompatibility Complices><IFN-Gamma-Inducing Factor Gene><IFN-gamma-Inducing Factor><IGIF><IGIF Gene><IL-1 Gamma><IL-1 Gamma Gene><IL-12><IL-15><IL-18><IL-18 Gene><IL-1g><IL-1g Gene><IL-2><IL-23><IL12><IL15><IL15 Protein><IL18><IL18 Protein><IL18 gene><IL1F4><IL1F4 Gene><IL2 Protein><Immune><Immune Cell Activation><Immune checkpoint inhibitor><Immune mediated therapy><Immune response><Immune system><Immunes><Immunochemical Immunologic><Immunocompetent><Immunologic><Immunologic Stimulation><Immunological><Immunological Stimulation><Immunologically><Immunologically Directed Therapy><Immunologics><Immunomodulation><Immunostimulation><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunotherapeutic agent><Immunotherapy><In Situ><In Vitro><Injections><Interferon-Gamma-Inducing Factor Gene><Interferon-gamma-Inducing Factor><Interleukin 18 (Interferon-Gamma-Inducing Factor)><Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene><Interleukin 18 Proprotein><Interleukin 18 Proprotein Gene><Interleukin 2><Interleukin 2 Precursor><Interleukin II><Interleukin-1 Gamma><Interleukin-1 Gamma Gene><Interleukin-12><Interleukin-15><Interleukin-15 Precursor><Interleukin-18><Interleukin-18 Precursor><Interleukin-18 Precursor Gene><Interleukin-2><Interleukine 2><Interleukine 2 Precursor><Interleukine II><Intervention><Intracellular Communication and Signaling><K lymphocyte><Knowledge><LAB7><Lesion><Local Cancer><Local Therapy><Localized Cancer><Localized Malignancy><Localized Malignant Neoplasm><Localized Therapy><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphatic nodes><Lymphocyte Mitogenic Factor><MC-38><MC38><MGC12320><MGC12320 Gene><MGC9721><Major Histocompatibility Complex><Major Histocompatibility Complices><Malignant><Malignant - descriptor><Malignant Cell><Malignant Melanoma><Malignant Neoplasms><Malignant Tumor><Melanoma><Metastasis><Metastasize><Metastatic Cancer><Metastatic Lesion><Metastatic Malignant Neoplasm><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Methods><Mice><Mice Mammals><Mitogenic Factor><Modeling><Murine><Mus><NK Cells><NK T cell><NKSF><NKT cell><Natural Killer Cell Stimulatory Factor><Natural Killer Cells><Natural Killer T cell><Neoplasm Metastasis><OX40L><PD-1 antibody><PD-L1><PD1 antibody><PDL-1><Pathway interactions><Patients><Peptides><Phase><Plasmids><Population><Predisposition><Primary Neoplasm><Primary Tumor><Process><Programmed Cell Death 1 Ligand 1><Programmed Death Ligand 1><Refractory><Resistance><S antigen><Secondary Neoplasm><Secondary Tumor><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Spleen><Spleen Reticuloendothelial System><Susceptibility><Synthetic Antigens><T cell growth factor><T cell response><T-Cell Activation><T-Cell Growth Factor><T-Cell Stimulating Factor><T-Cells><T-Lymphocyte><T8 Cells><T8 Lymphocytes><TNBC><TNFSF4><TNFSF4 gene><TXGP1><Technology><Therapeutic><Thymocyte Stimulating Factor><Tissues><Training><Transfection><Translations><Tumor Antigens><Tumor Cell><Tumor-Associated Antigen><Tumor-Derived><Work><aPD-1><aPD1><accessory cell><activate T cells><analytical tool><anti programmed cell death 1><anti-PD-1><anti-PD-1 Ab><anti-PD-1 antibodies><anti-PD-1 monoclonal antibodies><anti-PD1><anti-PD1 Ab><anti-PD1 antibodies><anti-PD1 monoclonal antibodies><anti-cancer><anti-cancer immunotherapy><anti-programmed cell death protein 1><anti-programmed cell death protein 1 antibodies><anti-programmed death-1 antibody><anti-tumor immune response><anti-tumor response><antiPD-1><antibody inhibitor><anticancer immunotherapy><biologic><biological signal transduction><cancer antigens><cancer cell><cancer immunotherapy><cancer metastasis><cancer microenvironment><cell growth><cell-based immunotherapy><cellular reprogramming><check point blockade><check point inhibition><checkpoint blockade><checkpoint inhibition><clinical translation><clinically translatable><comparative><conventional therapy><conventional treatment><cost><cytokine><deliver DNA><design><designing><determine efficacy><developmental><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><engineered nano particle><engineered nanoparticle><enhancer cassette><evaluate efficacy><examine efficacy><expression cassette><gene cassette><gene repair therapy><gene therapy><gene-based therapy><genetic cassette><genetic therapy><genomic therapy><host response><immune activation><immune cell therapy><immune check point blockade><immune check point inhibition><immune check point inhibitor><immune checkpoint blockade><immune checkpoint inhibition><immune competent><immune drugs><immune modulation><immune regulation><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapeutics><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunogenicity><immunologic reactivity control><immunologic therapeutics><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><immunotherapeutics><immunotherapy agent><immunotherapy for cancer><immunotherapy of cancer><immunotoxicity><improved><in vivo><individual patient><innovate><innovation><innovative><integration cassette><interleukin-23><killer T cell><lymph gland><lymph nodes><lymphnodes><malignancy><nano particle><nano particle delivery><nano-sized particle><nanoparticle><nanoparticle delivered><nanoparticle delivery><nanosized particle><natural killer T lymphocyte><neoplasm/cancer><neoplastic cell><next generation><non-viral gene delivery><nonviral gene delivery><novel><particle><pathway><prevent><preventing><programmed cell death ligand 1><programmed cell death protein ligand 1><programs><promoter cassette><protein death-ligand 1><recruit><reporter cassette><resistance cassette><resistant><selectable cassette><selection cassette><stop cassette><synergism><technology platform><technology system><thymus derived lymphocyte><toxic reaction in immunology><transcription cassette><transcriptional cassette><transcriptomics><transgene cassette><translation><treatment strategy><triple-negative breast cancer><triple-negative invasive breast carcinoma><tumor><tumor cell metastasis><tumor microenvironment><tumor specificity><tumor-specific antigen><αPD-1><αPD1>
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Stefan G Sarafianos

EMORY UNIVERSITY, ATLANTA, GA

Exploratory lead · 28/100
Above-average budget
Active award
$626,362
FY 2025

Project Title

Ultrapotent Inhibitors of Wild-type and Multi-drug Resistant HIV

Grant Number:

4R37AI076119-17

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2030

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT NIH guidelines for priority AIDS funding (NOT-OD-20-018) call for "next-generation therapies,,,that are longer acting,,,and less toxic", Our efforts over the past >15 years (R01AI076119, R37AI076119) resulted in the discovery of a novel mechanism of HIV inhibition that block...

Research Terms

<2'-deoxyadenosine><AIDS><AIDS Virus><AIDS drugs><AIDS prevention><AIDS/HIV><AZT><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Action Potentials><Address><Adverse effects><Affect><Anti-AIDS Agents><Anti-AIDS Drugs><Anti-HIV Agents><Anti-HIV Drugs><Anti-HIV resistance><Anti-HIV resistant><Anti-Human Immunodeficiency Virus Agents><Anti-viral Agents><Assay><Award><Azidothymidine><Binding><Bioassay><Biochemical><Biochemistry><Biological Assay><Biological Chemistry><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cell Body><Cell Count><Cell Culture Techniques><Cell Growth in Number><Cell Multiplication><Cell Number><Cell Proliferation><Cells><Cellular Proliferation><Clinic><Clinical><Clinical Trials><Collaborations><Combined Modality Therapy><Communicable Diseases><Crystallographies><Crystallography><DNA><DNA mutation><Data><Deoxyribonucleic Acid><Dose><Drug resistance in HIV><Drug usage><Drugs><EC 2.7.7.49><Early-Stage Clinical Trials><Evolution><Funding><Future><Generations><Genetic Change><Genetic defect><Genetic mutation><Goals><Guidelines><HIV><HIV Prevention><HIV drug resistance><HIV drug resistant><HIV therapy><HIV/AIDS><HIV/AIDS prevention><Head><Heart Muscle Cells><Heart myocyte><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Human Immunodeficiency Viruses><Infectious Diseases><Infectious Disorder><Instruction><LAV-HTLV-III><Letters><Liver Cells><Lymphadenopathy-Associated Virus><Lymphatic cell><Lymphocyte><Lymphocytic><Lytotoxicity><Manuscripts><Measurable><Measures><Medication><Methods><Molecular Interaction><Monitor><Multi-Drug Resistance><Multidrug Resistance><Multimodal Therapy><Multimodal Treatment><Multiple Drug Resistance><Multiple Drug Resistant><Mutation><NIH><National Institutes of Health><Nucleosides><Oral><PBMC><Paper><Pathway interactions><Patients><Peripheral Blood Mononuclear Cell><Pharmaceutical Preparations><Phase><Phase 1 Clinical Trials><Phase 2 Clinical Trials><Phase 3 Clinical Trials><Phase I Clinical Trials><Phase I Study><Phase II Clinical Trials><Phase III Clinical Trials><PrEP><Preparation><Printing><Productivity><Progress Reports><Publishing><RNA Seq><RNA Transcriptase><RNA sequencing><RNA-Dependent DNA Polymerase><RNA-Directed DNA Polymerase><RNAseq><Regimen><Research><Resistance><Resistance profile><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistant profile><Resistant to Multiple Drug><Resistant to multi-drug><Resistant to multidrug><Retroviridae><Retroviruses><Reverse Transcriptase><Reverse Transcriptase Inhibitors><Revertase><Safety><Serial Passage><Structure><T-Cells><T-Lymphocyte><Tenofovir><Therapeutic><Time><Toxic effect><Toxicities><United States National Institutes of Health><Universities><Vaccines><Viral><Viral Burden><Viral Load><Viral Load result><Viread><Virus><Virus Replication><Virus-HIV><Virus-Retrovirus><Work><ZDV><Zidovudine><access restrictions><analog><anti-viral compound><anti-viral drugs><anti-viral medication><anti-viral therapeutic><anti-virals><antiAIDS agent><azidodeoxythymidine><cardiomyocyte><cell culture><cell cultures><cell type><combination therapy><combined modality treatment><combined treatment><conference><convention><cytotoxicity><design><designing><drug candidate><drug resistant HIV><drug use><drug/agent><experiment><experimental research><experimental study><experiments><genome mutation><improved><inhibitor><insight><interdisciplinary approach><intervention design><lymph cell><multi-drug resistant><multi-modal therapy><multi-modal treatment><multidisciplinary approach><multidrug resistant><next generation><novel><pathway><phase 1 study><phase I protocol><phase II protocol><phase III protocol><posters><pre-clinical development><pre-exposure prophylaxis><preclinical development><preparations><prototype><resistance mechanism><resistance mutation><resistance to HIV drug><resistance to anti-HIV><resistant><resistant mechanism><resistant mutation><resistant to HIV drug><structural biology><summit><symposia><symposium><therapy design><thymus derived lymphocyte><transcriptome sequencing><transcriptomic sequencing><treatment design><treatment strategy><trend><viral multiplication><viral replication><virology><virus multiplication>
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Jeffrey Neal Weiser

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Exploratory lead · 28/100
Above-average budget
Active award
$610,200
FY 2025

Project Title

Mechanisms of Pneumococcal Persistence During Carriage

Grant Number:

4R37AI038446-31

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/1996

End Date:

6/30/2029

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY (See instructions): This is an application for a four year continuation of a R37 Merit Award (years 5-9). For the past 30 years my laboratory has studied Streptococcus pneumoniae (Spn), a leading human respiratory pathogen. Our focus has been on upper respiratory tract (URT) coloni...

Research Terms

<Acylneuraminyl hydrolase><Affect><Award><Bacterial Infections><Biological><Biology><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cell Coat><Cell Communication and Signaling><Cell Signaling><Characteristics><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><D pneumoniae><D. pneumoniae><Data><Diplococcus pneumoniae><Disease><Disorder><Exoglycosidases><Funding><Glycocalyx><Grippe><Human><IL-1><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL1><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immune signaling><Immunology><Infant><Infection><Influenza><Influenza Virus><Innate Immunity><Instruction><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin I><Interleukin-1><Interleukin-17><Intracellular Communication and Signaling><Laboratories><Lymphocyte-Stimulating Hormone><Macrophage Cell Factor><Mice><Mice Mammals><Modern Man><Modification><Mucosa><Mucosal Tissue><Mucous Membrane><Mucous body substance><Mucus><Murine><Mus><N-Acylneuraminate Glycohydrolases><Native Immunity><Natural Immunity><Neuraminidase><Non-Specific Immunity><Nonspecific Immunity><Oligosaccharide Sialidase><Organism><Pneumococcus><Pneumonia><Production><RNA Seq><RNA sequencing><RNAseq><Research><Respiratory infectious agent><Respiratory tract pathogen><Role><S pneumoniae><S. pneumoniae><Serotyping><Sialidase><Signal Transduction><Signal Transduction Systems><Signaling><Streptococcus pneumoniae><Surface><T Helper Factor><Transmission><Upper respiratory tract><age associated><age correlated><age dependent><age linked><age related><age specific><bacteria infection><bacterial disease><bacterial genetics><biologic><biological signal transduction><co-infection><coinfection><density><exo alpha sialidase><in vivo><infancy><infantile><influenzavirus><living system><lymphocyte activating factor><mouse model><mucous><murine model><pathogen><programs><respiratory pathogen><response><social role><tool><transcriptome sequencing><transcriptomic sequencing><transmission process><upper airway tract>
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Bruce R Blazar

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 28/100
Above-average budget
Active award
$589,718
FY 2025

Project Title

In Vivo Prevention of Murine GVHD

Grant Number:

5R37AI034495-33

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2022

End Date:

6/30/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract Our overall goals are focus on the prevention and treatment of graft-vs-host disease (GVHD) via innate lymphoid type 2 cell (ILC2) anti-inflammatory and tissue reparative properties. We found that host ILC2s in are eliminated by total body irradiation {TBI} or chemotherapy and remain deplet...

Research Terms

<Acceleration><Acute GVHD><Acute Graft Versus Host Disease><Amphiregulin><Anthelone U><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Autoimmune Status><Autoimmunity><Automobile Driving><Autoregulation><B220><Biological><Blood Precursor Cell><Body Tissues><Bone Marrow Grafting><Bone Marrow Transplant><Bone Marrow Transplantation><CD45><CRGF><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Cycle Control><Cell Cycle Regulation><Cell Growth in Number><Cell Interaction><Cell Multiplication><Cell Proliferation><Cell Signaling><Cell Therapy><Cell secretion><Cell-to-Cell Interaction><Cells><Cellular Proliferation><Cellular Secretion><Chimerism><Clinical Treatment Moab><Clinical Trials><Co-culture><Cocultivation><Coculture><Coculture Techniques><Colorectum Cell-Derived Growth Factor><Data><Development><Disease><Disorder><Drugs><EGFR Blocker><EGFR Inhibitor><EGFR Tyrosine Kinase Inhibitor><EGFR-TK Inhibitor><Enhancer-Binding Protein GATA3><Environment><Epidermal Growth Factor><Epidermal Growth Factor Receptor Inhibitor><Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor><Epidermal Growth Factor-Urogastrone><Epithelial Cells><Epithelium><Equilibrium><Funding><GATA-3 factors><GATA-3 protein><GATA-Binding Protein 3><GATA3><GATA3 gene><GATA3 protein><GATA3 transcription factor><GI Stem cell><GP180><Gene Expression><Generations><Goals><Goblet Cells><Grafting Procedure><GvHD><Height><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Homeostasis><Homologous Wasting Disease><Human><IL-13><IL-13Ra><IL13><IL13RA1><IL13RA1 gene><Immune><Immune response><Immune system><Immunes><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><In Vitro><Inflammatory><Infusion><Infusion procedures><Injury><Institution><Interleukin-13><Interleukin-13 Receptor Alpha><Interleukin-13 Receptor Alpha 1><Intestinal><Intestines><Intracellular Communication and Signaling><KO mice><Keratinocyte-Derived Autocrine Factor><Knock-out><Knock-out Mice><Knockout><Knockout Mice><LY5><Literature><Lymphatic cell><Lymphocyte><Lymphocytic><Lymphoid><Marrow Transplantation><Measures><Mediating><Medication><Mice><Mice Mammals><Minnesota><Modeling><Modern Man><Monoclonal Antibodies><Mucins><Mucus Glycoprotein><Murine><Mus><NR4><Natural regeneration><Nature><Null Mouse><Organ Transplantation><Organ Transplants><Organoids><PTPRC><PTPRC gene><Paneth Cells><Patients><Pharmaceutical Preparations><Phase><Physiological Homeostasis><Population><Prevention><Process><Production><Progenitor Cells><Prognosis><Progress Reports><Proliferating><Property><Protein Secretion><Refractory><Regeneration><Regimen><Regulatory T-Lymphocyte><Reporting><Research><Rodent><Rodentia><Rodents Mammals><Role><Runt Disease><Schwannoma-Derived Growth Factor><Signal Transduction><Signal Transduction Systems><Signaling><Small Intestines><Solid><Stem Cell Research><Steroid Compound><Steroid Resistance><Steroid Resistant><Steroids><Supporting Cell><T-Cells><T-Lymphocyte><T200><Testing><Time><Tissues><Total Body Irradiation><Transplant Recipients><Transplantation Conditioning><Treg><Universities><Urogastrone><Whole-Body Irradiation><Whole-Body Radiation><Wild Type Mouse><acute graft vs host disease><acute graft vs. host disease><balance><balance function><beta-Urogastrone><biologic><biological signal transduction><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><bowel><cell based intervention><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chemotherapy><colorectal cell-derived growth factor><colorectal-associated growth factor><colorectum-associated growth factor><congenic><cytokine><developmental><disease control><disorder control><driving><drug/agent><dysbacteriosis><dysbiosis><dysbiotic><epithelium regeneration><gastrointestinal stem cell><graft versus host disease><graft vs host disease><graft vs. host disease><gut progenitor><gut stem cell><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><host response><immune system response><immunoresponse><in vivo><infusions><inhibitor><injuries><insight><intestinal progenitor><intestinal stem cells><keratinocyte autocrine factor><lymph cell><mAbs><microbial imbalance><migration><monoclonal Abs><neutralizing mAb><neutralizing monoclonal antibodies><new approaches><novel approaches><novel strategies><novel strategy><organ allograft><organ graft><organ xenograft><peripheral blood><prevent><preventing><regenerate><regenerate epithelium><regulatory T-cells><repair><repaired><small bowel><social role><stem cell study><stem cells><thymus derived lymphocyte><trafficking><translational applications><translational impact><transplant patient><wildtype mouse>
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Erin A McClure

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Exploratory lead · 28/100
Above-average budget
Active award
$580,584
FY 2025

Project Title

Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trial

Grant Number:

5R37CA237245-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2019

End Date:

8/31/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT This proposal is in response to PAR-21-138: Method to Extend Research in Time (MERIT) Award Extension Request, which includes a 2-year MERIT extension request to support new data collection focused on cannabis-tobacco co-use and the implications of cannabis use on tobacco c...

Research Terms

<21+ years old><Abstinence><Adult><Adult Human><Age><Award><Biochemical><Cannabis><Characteristics><Cigarette><Data><Data Collection><Dose><Electronic Nicotine Delivery Product><Electronic Nicotine Delivery Systems><Electronic cigarette><Enrollment><Evaluation><Exclusion><Frequencies><Funding><Goals><Literature><Measures><Methods><Nicotine><Outcome><Parents><Participant><Pattern><Play><Population><Procedures><Recommendation><Research><Role><Sampling><Severities><Smoking><THC co-use><THC use><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Time><Tobacco><Tobacco Cessation><Tobacco Consumption><Tobacco Use Cessation><Tobacco use><United States><Youth><Youth 10-21><adulthood><ages><cannabis use><cigarette smoking><cigarette use><combustible tobacco><design><designing><e-cig><e-cig cessation><e-cig use><e-cigarette><e-cigarette cessation><e-cigarette use><ecig><ecig cessation><ecig use><ecigarette><ecigarette use><electronic cigarette use><electronic nicotine delivery device><electronic nicotine distribution system><enroll><falls><interest><marijuana use><nicotine cessation><parent><parent award><parent grant><parent project><participant enrollment><patient enrollment><prospective><quitting e-cigarettes><quitting e-cigs><quitting ecigarettes><quitting ecigs><recruit><response><social role><tobacco product use><tobacco products><treatment trial><trend><vaping nicotine><varenicline><youth age>
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Tomi F Akinyemiju

DUKE UNIVERSITY, DURHAM, NC

Exploratory lead · 28/100
Above-average budget
Active award
$554,473
FY 2025

Project Title

A Role of Multilevel Healthcare Access Dimensions in Ovarian Cancer Disparities

Grant Number:

5R37CA233777-08

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Ovarian cancer accounts for more deaths than any other cancer of the female reproductive system. In 2021, there were 21,410 new cases of OC and 13,770 deaths. Remarkable progress has been made in ovarian cancer treatment, resulting in a 33% decline in mortality in the past few decades; unfortunately...

Research Terms

<Access to Care><Address><Administrative Supplement><After Care><After-Treatment><Aftercare><Alabama><Automobile Driving><Award><Biological><Biological Markers><Black><Black race><Cancer Patient><Cancer Treatment><Cancer health equity><Caucasian Females><Caucasian Women><Censuses><Cessation of life><Chronic stress><Cognitive Discrimination><Consultations><Data><Data Bases><Data Set><Databases><Death><Dimensions><Discrimination><Disparities><Disparity><Epidemiology><Equity><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Female Genital System><Female Reproductive Cancer><Grant><Guidelines><Gynecologic Cancer><Gynecologic Oncology><Gynecological Cancer><Health><Health Care><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Health Services Accessibility><Hispanic><Individual><Intervention><Joints><Knowledge><Link><Literature><Location><Long-term trends><Longer-term trends><Longitudinal trends><Malignant Female Reproductive System Neoplasm><Malignant Gynecologic Neoplasm><Malignant Gynecologic Tumor><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Ovarian Neoplasm><Malignant Ovarian Tumor><Malignant Tumor of the Female Reproductive System><Malignant Tumor of the Ovary><Malignant neoplasm of ovary><Measurement><Measures><Mediating><Medicare><Methodology><Molecular><Neighborhoods><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Operative Procedures><Operative Surgical Procedures><Outcome><Ovary Cancer><Parents><Pathway interactions><Patients><Population><QOC><Quality of Care><Racial Group><Recommendation><Reporting><Research Infrastructure><Role><Rural><Subgroup><Supportive Therapy><Supportive care><Surgical><Surgical Interventions><Surgical Procedure><Survey Instrument><Surveys><Survival Rate><Time><Title 18><Treatment outcome><US State><White Females><White Women><access to health care><access to health services><access to services><access to treatment><accessibility of health care><accessibility to health care><accessibility to health services><administrative data base><administrative database><anti-cancer therapy><availability of services><bio-markers><biologic><biologic marker><biomarker><black female><black women><cancer diagnosis><cancer disparity><cancer epidemiology><cancer health disparity><cancer registry><cancer survival><cancer therapy><cancer-directed therapy><cancer-related health disparity><care access><care resources><chemotherapy><cohort><consultation><data base><differences due to race><differences in health><differences in race><differs by race><differs in race><disparities in race><disparity due to race><disparity in cancer><driving><end of life care><epidemiologic><epidemiological><ethnic subgroup><ethnicity group><female reproductive body system><female reproductive organ system><female reproductive system><gynecologic body system><gynecologic malignancy><gynecologic organ system><gynecological malignancy><health care access><health care availability><health care organization><health care resources><health care service access><health care service availability><health care service organization><health difference><health insurance for disabled><health service access><health services availability><improved><indexing><inequality due to race><inequity due to race><mortality><neoplasm registry><ovarian cancer><parent><parent grant><pathway><patient clinician engagement><patient clinician interaction><patient clinician relationship><patient doctor engagement><patient doctor interaction><patient doctor relationship><patient physician engagement><patient physician interaction><patient physician relationship><patient provider engagement><patient provider interaction><patient provider relationship><population based><post treatment><preference><prospective><race based differences><race based disparity><race based inequality><race based inequity><race differences><race disparity><race related differences><race related disparity><race related inequality><race related inequity><racial difference><racial disparity><racial inequality><racial inequity><racial population><racial subgroup><racially different><racially unequal><recruit><saliva sample><salivary sample><service availability><social><social role><stressor><surgery><survival disparity><survival outcome><translational impact><treatment access><treatment guidelines><treatment strategy>
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E. Michael Ostap

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 28/100
Above-average budget
Active award
$514,773
FY 2025

Project Title

Molecular function of Myosin-l

Grant Number:

5R37GM057247-27

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/1998

End Date:

11/30/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract The goal of this R37-supported research program is to obtain a fundamental understanding of how myosin motors function and interact with proteins, lipid membranes, and other biomolecules to power structural arrangements and motile events that are crucial for eukaryotic life. Our strategy...

Research Terms

<Acetylation><Actin Filaments><Actin-Activated ATPase><Actin-S1 ATPase><Actins><Active Sites><Actomyosin Subfragment 1 ATPase><Adaptor Protein><Adaptor Protein Gene><Adaptor Signaling Protein><Adaptor Signaling Protein Gene><Address><Adhesions><Affect><Affinity><Back><Binding><Binding Proteins><Binding Sites><Biochemical><Biochemistry><Biological><Biological Chemistry><Biophysics><Body Tissues><Cadherin-1><Cadherins><Calibration><Cardiac><Cell Body><Cell Communication and Signaling><Cell Function><Cell Membrane Lipids><Cell Physiology><Cell Process><Cell Signaling><Cell-Cell Adhesion><Cells><Cellular Function><Cellular Matrix><Cellular Mechanotransduction><Cellular Physiology><Cellular Process><Cellular biology><Collaborations><Combining Site><Communities><Contracting Opportunities><Contracts><Coupled><Coupling><Cryo-electron Microscopy><Cryoelectron Microscopy><Cytoskeletal Gene><Cytoskeletal Proteins><Cytoskeletal System><Cytoskeleton><Development><Dorsum><Drosophila><Drosophila genus><E-Cadherin><Electron Cryomicroscopy><Engineering><Epithelial Calcium-Dependent Adhesion Protein><Epithelial-Cadherin><Event><FRET><Family><Fluorescence Resonance Energy Transfer><Funding><Förster Resonance Energy Transfer><Generalized Growth><Generations><Geometry><Goals><Growth><Health><Heavy Meromyosin Subfragment-1><In Vitro><Individual><Inositide Phospholipids><Inositol Phosphoglycerides><Inositol Phospholipids><Intestinal><Intestines><Intracellular Communication and Signaling><Intracellular Transport><Intuition><Investigation><Investments><Involuntary Muscle><Isoforms><Kinetics><Laboratories><Left><Life><Ligand Binding Protein><Ligand Binding Protein Gene><Literature><Magnesium ADP><Measurement><Measures><Mechanical Signal Transduction><Mechanics><Mechanosensory Transduction><Mediating><Membrane><Membrane Lipids><Methods><MgADP><Microfilaments><Modeling><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Motors><Molecular Probes><Molecular Stereochemistry><Motility><Motor><Motor Pathways><Myofilaments><Myosin ATPase><Myosin Adenosine Triphosphatase><Myosin Adenosinetriphosphatase><Myosin I><Myosin S-1><Myosin Subfragment-1><Myosin Type I><Myosins><N-terminal><NH2-terminal><Normal Cell><Organism><Outcome><Output><Paper><Pathway interactions><Pattern><Phosphates><Phosphatidyl Inositol><Phosphatidylinositols><Phosphoinositides><Phylogenetic Analysis><Phylogenetics><Physiologic><Physiological><Play><Polymers><Population><Position><Positioning Attribute><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Preparation><Process><Progress Reports><Property><Protein Binding><Protein Isoforms><Protein Modification><Proteins><PtdIns><Publications><Publishing><Reactive Site><Regulation><Reporting><Research><Research Support><Resolution><Role><Rotation><Scientific Publication><Series><Signal Transduction><Signal Transduction Systems><Signaling><Site><Skeletal Muscle><Smooth Muscle><Speed><Structure><Subcellular Process><Subgroup><System><Tail><Techniques><Testing><Time><Tissue Growth><Tissues><Touch><Touch sensation><Tropomyosin><Uvomorulin><Voluntary Muscle><Work><adapter protein><arm><biologic><biological signal transduction><biophysical equipment><biophysical foundation><biophysical principles><biophysical sciences><biophysical tools><bound protein><bowel><cell biology><conformation><conformational><conformational state><conformationally><conformations><cryo-EM><cryoEM><cryogenic electron microscopy><design><designing><developmental><dimer><disease causing variant><disease-causing allele><disease-causing mutation><experiment><experimental research><experimental study><experiments><feeding><force sensor><fruit fly><graduate student><inorganic phosphate><insight><intracellular skeleton><intuitive><kinetic model><laser tweezer><living system><mechanic><mechanical><mechanical force><mechanical load><mechanical properties><mechanosensing><mechanotransduction><member><membrane structure><novel><ontogeny><optic trap><optical traps><optical tweezers><pathogenic allele><pathogenic variant><pathway><physical property><planar cell polarity><polymer><polymeric><polymerization><preparations><prevent><preventing><programs><protein complex><rate of change><recruit><resolutions><response><single molecule><social role><stem><tactile sensation><therapeutic target><tool><tool development><virtual>
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Lisa Gorham

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 28/100
Training-friendly
Active award
$36,673
FY 2025

Project Title

Very Preterm Birth and Cortical Expansion in Early Life

Grant Number:

1F30HD119918-01

Activity Code:

F30

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary From infancy to adulthood, the human cortex expands three-fold, with consequences for cognition and behavior. While preclinical and histological research suggests that cortical expansion is driven by underlying microstructural processes including dendritic arborization and synaptogen...

Research Terms

<0-11 years old><10 year old><10 years of age><21+ years old><3rd trimester><AD/HD><ADHD><ASD><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Age><Anatomic Sites><Anatomic structures><Anatomy><Anisotropy><Anxiety><Area><Attention deficit hyperactivity disorder><Autism><Autistic Disorder><Award><Behavior><Behavioral><Biological><Brain><Brain Nervous System><Causality><Child><Child Psychiatry><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Skills><Cognition><Cognition Disorders><Cognitive><Communication><Computer software><DWI (diffusion weighted imaging)><DWI-MRI><Data><Data Analyses><Data Analysis><Dedications><Development><Developmental Process><Diffusion><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Dysfunction><Early Infantile Autism><Early Intervention><Early identification><Early treatment><Encephalon><Etiology><Executive Dysfunction><Executive Function Deficit><Executive Impairment><Exhibits><Foundations><Functional disorder><Generalized Growth><Gestation><Goals><Growth><Histologic><Histologically><Human><Impairment><Individual Differences><Infant><Infantile Autism><Intervention><Kanner's Syndrome><Last Trimester><Lead><Life><Linear Models><Link><Long-term cohort><Longitudinal cohort><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Maps><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Mentors><Mentorship><Modeling><Modern Man><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Neonatal><Nuclear Magnetic Resonance Imaging><Outcome><Parietal><Pattern><Pb element><Physicians><Physiopathology><Population><Predominantly Hyperactive-Impulsive Type Attention-Deficit Disorder><Predominantly Hyperactive-Impulsive Type Hyperactivity Disorder><Pregnancy><Premature Birth><Prematurely delivering><Preterm Birth><Process><Psychiatric Disease><Psychiatric Disorder><Psychiatrist><Psychological Health><Research><Risk><Risk Factors><Sampling><Scientist><Software><Sorting><Structure><Surface><Symptoms><Testing><Third Pregnancy Trimester><Third Trimester><Tissue Growth><Training><United States National Institutes of Health><Universities><Vulnerable Populations><Washington><Work><Zeugmatography><adulthood><age 10 years><ages><anxiety symptoms><anxious symptom><association cortex><association cortical><association cortices><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><behavior outcome><behavior phenotype><behavioral outcome><behavioral phenotyping><biologic><brain based><career><causation><co-morbid><co-morbidity><cognitive disease><cognitive disorder><cognitive syndrome><cohort><comorbidity><cortex mapping><cortical map><cortical mapping><dMRI><data interpretation><developmental><diffused><diffuses><diffusing><diffusion tensor imaging><diffusions><disease causation><early childhood><early therapy><executive control><executive function><experience><extreme prematurity><extremely premature infant><extremely preterm><extremely preterm infant><heavy metal Pb><heavy metal lead><high risk group><high risk individual><high risk people><high risk population><improved><infancy><infantile><innovate><innovation><innovative><interest><juvenile><juvenile human><kids><mental illness><multi-modality><multimodality><neural imaging><neuro-imaging><neuroimaging><neurological imaging><ontogeny><pathophysiology><pediatric><peer><pre-clinical><preclinical><premature childbirth><premature delivery><preterm delivery><prospective><psychiatric illness><psychiatric symptom><psychological disorder><skills><structural imaging><substantia alba><synapse formation><synaptogenesis><ten year old><ten years of age><very premature><very preterm><vulnerable group><vulnerable individual><vulnerable people><white matter><youngster>
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Minna Roh

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 26/100
Solid budget
Active award
$352,275
FY 2026

Project Title

Mitochondrial lateral transfer during metastasis

Grant Number:

4R37CA247994-06

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

Project Summary Macrophages play paradoxical roles in cancer: They can be tumoricidal, but in many cancers, macrophages promote metastasis. There has been growing evidence that macrophages can modulate cell behavior via unconventional cell contact-mediated communication in development and homeostasi...

Research Terms

<1-Phosphatidylinositol 3-Kinase><Active Oxygen><Affect><Automobile Driving><Autoregulation><Award><Behavior><Bioenergetics><Brachydanio rerio><Breast Cancer><Breast Cancer Cell><Breast Cancer cell line><Breast tumor cell line><Cancers><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Function><Cell Growth in Number><Cell Interaction><Cell Multiplication><Cell Physiology><Cell Process><Cell Proliferation><Cell Signaling><Cell-to-Cell Interaction><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Proliferation><Collaborations><Communication><Communications Media><Communities><Cues><Cytoplasm><Danio rerio><Darkness><Development><Disseminated Malignant Neoplasm><Electron Microscopy><Environment><Event><Exhibits><Forms of Communication><Future><Generations><Global Change><Goals><Homeostasis><Human><Immune><Immune mediated therapy><Immune system><Immunes><Immunologically Directed Therapy><Immunotherapy><In Vitro><Injections><Intracellular Communication and Signaling><Lateral><Macrophage><Malignant Breast Neoplasm><Malignant Cell><Malignant Melanoma><Malignant Neoplasms><Malignant Tumor><Mediating><Melanoma><Melanoma Cell><Melanoma Metastasis><Metabolic><Metastasis><Metastasize><Metastatic Cancer><Metastatic Lesion><Metastatic Malignant Neoplasm><Metastatic Mass><Metastatic Melanoma><Metastatic Neoplasm><Metastatic Tumor><Mitochondria><Modern Man><Morphology><Mφ><Neoplasm Metastasis><Organelles><Oxygen Radicals><PI-3 Kinase><PI3-Kinase><PI3CG><PI3KGamma><PI3k><PIK3><PIK3CG><PIK3CG gene><Pathway interactions><Patients><Phenotype><Phosphatidylinositol 3-Kinase><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Physiological Homeostasis><Play><Population><Primary Neoplasm><Primary Tumor><Pro-Oxidants><Process><Proliferating><PtdIns 3-Kinase><Publishing><Reactive Inhibition><Reactive Oxygen Species><Receptor Protein><Reporting><Resolution><Respiration><Role><Secondary Neoplasm><Secondary Tumor><Side><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Solid Neoplasm><Solid Tumor><Source><Stromal Cells><Structure><Subcellular Process><System><Testing><Tumor Cell><Tumor-associated macrophages><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><Update><Utah><Visualization><Work><Zebra Danio><Zebra Fish><Zebrafish><behavior change><biological signal transduction><breast tumor cell><cancer cell><cancer metastasis><cancer microenvironment><cell behavior><cellular behavior><developmental><driving><experiment><experimental research><experimental study><experiments><extracellular><imaging approach><imaging based approach><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><in vivo><knock-down><knockdown><light microscopy><malignancy><malignant breast tumor><melanoma cancer model><melanoma model><melanoma tumor model><mitochondrial><mouse model><murine model><neoplasm/cancer><neoplastic cell><pathway><receptor><resolutions><respiratory mechanism><response><restoration><social role><tool><tumor><tumor cell metastasis><tumor microenvironment>
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Shanshan Jiang

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 26/100
Solid budget
Active award
$350,599
FY 2026

Project Title

Quantitative CEST MRI for GBM Early Response Prediction and Biopsy Guidance

Grant Number:

4R37CA248077-06

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2025

End Date:

11/30/2027

Project Abstract

SUMMARY Despite advances in therapy, the most aggressive form of brain tumor, glioblastoma, remains almost universally fatal. The first-line therapy for this devastating cancer, with a high rate of local failure and a median survival of only 14.6 months, is maximum feasible surgical resection, foll...

Research Terms

<21+ years old><Abscission><Acceleration><Address><Adult><Adult Human><After Care><After-Treatment><Aftercare><Amides><Angiogenesis Antagonists><Angiogenesis Blockers><Angiogenesis Inhibitors><Angiogenetic Antagonists><Angiogenetic Inhibitors><Angiogenic Antagonists><Angiogenic Inhibitors><Angiostatic Agents><Anti-Angiogenetic Agents><Anti-Angiogenic Agents><Anti-Angiogenic Drugs><Antiangiogenesis Agents><Antiangiogenic Agents><Antiangiogenic Drugs><Biopsy><Brain Neoplasia><Brain Neoplasms><Brain Tumors><Cancers><Cell Body><Cells><Chemicals><Clinical><Clinical Management><Clinical Paths><Clinical Pathways><Clinical Trials><Diagnostic><Early identification><Excision><Experimental Therapies><Extirpation><Failure><Gadolinium><Gd element><Glial Cell Tumors><Glial Neoplasm><Glial Tumor><Glioblastoma><Glioma><Goals><Grade IV Astrocytic Neoplasm><Grade IV Astrocytic Tumor><Grade IV Astrocytoma><H+ element><Hydrogen Ions><Image><Imaging Device><Imaging Instrument><Imaging Procedures><Imaging Technics><Imaging Techniques><Imaging Tool><Infiltration><Intratumoral heterogeneity><Investigational Therapies><Investigational Treatments><Local Therapy><Localized Therapy><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malignant Glial Neoplasm><Malignant Glial Tumor><Malignant Glioma><Malignant Neoplasms><Malignant Neuroglial Neoplasm><Malignant Neuroglial Tumor><Malignant Tumor><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Modality><Molecular><Motion><NMR Imaging><NMR Tomography><Neovascularization Inhibitors><Neuroglial Neoplasm><Neuroglial Tumor><Neurological Surgery><Neurosurgical Procedures><Newly Diagnosed><Nuclear Magnetic Resonance Imaging><Operative Procedures><Operative Surgical Procedures><Parents><Pathologic><Patients><Pattern><Peripheral><Primary Brain Neoplasms><Primary Brain Tumors><Process><Prognosis><Prospective Studies><Proteins><Protocol><Protocols documentation><Protons><QOL improvement><Radiation therapy><Radiotherapeutics><Radiotherapy><Recurrent Neoplasm><Recurrent tumor><Removal><Resected><Residual><Residual state><Resolution><Risk Assessment><Running><Scanning><Site><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Techniques><Temodal><Temodar><Testing><Time><Tissue Sample><Treatment Protocols><Treatment Regimen><Treatment Schedule><Zeugmatography><adulthood><antiangiogenic><chemotherapy><clinical practice><data space><deep learning><deep learning method><deep learning strategy><design><designing><determine efficacy><diagnosis standard><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experimental therapeutic agents><experimental therapeutics><glial-derived tumor><glioblastoma multiforme><heterogeneity in tumors><high risk><image-based method><imaging><imaging method><imaging modality><improved><improvements in QOL><improvements in quality of life><in vivo><intra-tumoral heterogeneity><intratumor heterogeneity><irradiation><malignancy><methazolastone><multiparametric imaging><neoplasm recurrence><neoplasm/cancer><neural imaging><neuro-imaging><neuro-oncology><neuroglia neoplasm><neuroglia tumor><neuroimaging><neurological imaging><neurooncology><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><parent><patient prognosis><perfusion imaging><physical property><post treatment><predict responsiveness><predicting response><prognostic ability><prognostic power><prognostic utility><prognostic value><prospective research study><prospective survey><quality of life improvement><radiation treatment><reconstruction><recruit><resection><resolutions><response><response to therapy><response to treatment><spongioblastoma multiforme><surgery><temozolomide><therapeutic response><therapy response><tool><treatment effect><treatment response><treatment responsiveness><treatment with radiation><tumor><tumor heterogeneity><tumors in the brain>
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Elizabeth Planalp

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 26/100
Training-friendly
Career award
$129,600
FY 2021

Project Title

Neurobehavioral Development of Emotion Regulation in Young Children

Grant Number:

5K01MH113710-04

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/5/2018

End Date:

3/31/2023

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT Early life experiences play a critical role in shaping behavior. From birth to two years of age, brain and behavioral development are continuously and interdependently influenced by environmental characteristics. Yet little is known about early genetic, environmental and ...

Research Terms

<0-11 years old><0-4 weeks old><2 year old><2 years of age><Affective><Age-Months><Ammon Horn><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Basal Ganglia><Basal Nuclei><Behavior><Behavioral><Biological><Biometrics><Biometry><Biostatistics><Birth><Brain><Brain Nervous System><Characteristics><Child><Child Behavior><Child Development><Child Rearing><Child Youth><Childhood><Children (0-21)><Cognitive><Complex><Cornu Ammonis><Data><Data Set><Dataset><Development><Disease><Disorder><Early identification><Emotional><Emotions><Encephalon><Environment><Environmental Factor><Environmental Risk Factor><Faculty><Family><Funding><Gene x Environment Interaction><Generalized Growth><Genetic><Gestation><Goals><Growth><GxE interaction><Hereditary><Heritability><Hippocampus><Hippocampus (Brain)><Incidence><Infant><Infant Development><Infant and Child Development><Inherited><Institution><Interdisciplinary Research><Interdisciplinary Study><Knowledge><Laboratories><Life><Life Experience><Limbic System><MR Imaging><MR Tomography><MRI><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methods><Modeling><Mothers><Multidisciplinary Collaboration><Multidisciplinary Research><NIMH><NMR Imaging><NMR Tomography><National Institute of Mental Health><Nature><Neural Development><Newborn Infant><Newborns><Nuclear Magnetic Resonance Imaging><Parenting><Parenting behavior><Parents><Parturition><Personality><Play><Position><Positioning Attribute><Pregnancy><Pregnant Women><Problem behavior><Publishing><Questionnaires><Research><Research Support><Role><Sampling><Science><Shapes><Social Behavior><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Stress><Structure><Survey Instrument><Surveys><System><Thalamic structure><Thalamus><Time><Tissue Growth><Training><Twin Multiple Birth><Twins><Universities><Wisconsin><Work><Zeugmatography><affective neuroscience><age 2 years><aged 2 years><aged brain><aged two years><aging brain><amygdaloid nuclear complex><behavior phenotype><behavioral phenotyping><behavioral problem><career development><childrearing><developmental><early childhood><emotion dysregulation><emotion regulation><emotional dysregulation><emotional expression><emotional regulation><environment effect on gene><environmental risk><environmental stresses><environmental stressor><expectant mother><expecting mother><experience><expression of emotion><externalizing behavior><gene environment interaction><hippocampal><improved><infancy><infant temperament><infantile><informal education><informal instruction><informal learning><innovate><innovation><innovative><insight><multi-modality><multimodality><neural><neural circuit><neural circuitry><neural correlate><neural mechanism><neuro-imaging><neurobehavioral><neurocircuitry><neurodevelopment><neuroimaging><neuromechanism><newborn child><newborn children><novel><ontogeny><pediatric><pregnant mothers><relating to nervous system><showing emotion><social><social role><sociobehavior><sociobehavioral><statistical analysis><stem><stressor><synaptic circuit><synaptic circuitry><tenure process><tenure track><thalamic><two year old><two years of age><youngster>
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Kevin J. Staley

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 26/100
Likely hiring
$124,328
FY 2021

Project Title

Neuronal ion and volume shifts after acute brain injury

Grant Number:

3R35NS116852-01S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2020

End Date:

4/30/2021

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROPOSAL ABSTRACT We propose to test the accuracy and feasibility of a new, time-resolved measure of cell death after organophosphate (OP) poisoning in a murine model of OP-induced status epilepticus. This novel assay was developed as part of the grant, “Mechanisms of cell death during epileptogenes...

Research Terms

<2-photon><Acute Brain Injuries><Anticonvulsant Agent><Anticonvulsant Drugs><Anticonvulsants><Anticonvulsive Agents><Anticonvulsive Drugs><Apoptosis><Apoptosis Pathway><Apoptotic><Applications Grants><Assay><Autopsy><Award><Bioassay><Biologic Assays><Biological Assay><Biological Markers><Caspase><Caspase Gene><Cell Body><Cell Death><Cell-Death Protease><Cells><Cellular Assay><Cessation of life><Coloring Agents><Cre Lox technology><Cre LoxP system><Cre lox recombination system><Cre lox system><Cre recombinase/LoxP technology><Cysteine Endopeptidases><Cysteine Protease><Cysteine Proteinases><Data><Death><Di-isopropylphosphorofluoridate><Diisopropylfluorophosphate><Diisopropylphosphofluoridate><Dyes><EEG><Electroencephalography><Epileptogenesis><Experimental Therapies><Exposure to><Extinction><Extinction (Psychology)><Fluorescence><Fluostigmine><Funding><Future><Generalized Status Epilepticus><Genetic><Grant><Grant Proposals><Histologic><Histologically><Hortega cell><ICE-like protease><Image><Individual><Injury><Intervention><Intervention Strategies><Investigational Therapies><Investigational Treatments><Ions><Isoflurophate><Label><Measures><Methods><Mice><Mice Mammals><Microglia><Monitor><Murine><Mus><Necrosis><Necrotic><Neonatal Brain Injury><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurologic outcome><Neurological outcome><Neurons><Neurosciences><Organophosphates><Paper><Pathway interactions><Population><Postdoc><Postdoctoral Fellow><Predictive Value><Predisposition><Programmed Cell Death><Progress Reports><Proteins><Publishing><Research Associate><Resolution><Role><Seizures><Source><Staining method><Stains><Status Epilepticus><Susceptibility><Testing><Time><Toxic effect><Toxicities><Transgenic Organisms><base><behavioral extinction><bio-markers><biologic marker><biomarker><cell assay><cystein protease><cystein proteinase><cysteine endopeptidase><experience><experiment><experimental research><experimental study><experimental therapeutic agents><experimental therapeutics><fluoro jade><gitter cell><imaging><improved><in vivo><injuries><interventional strategy><mesoglia><microglial cell><microgliocyte><mouse model><murine model><necrocytosis><necropsy><nerve cell death><nerve cell loss><neuron cell death><neuron cell loss><neuron death><neuron loss><neuron toxicity><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal loss><neuronal patterning><neuronal toxicity><neuropathology><neurotoxic><neurotoxicity><novel><organophosphate poisoning><parent grant><pathway><perivascular glial cell><post-doc><post-doctoral><postmortem><protein expression><recombinase-mediated cassette exchange><resilience><selective expression><selectively expressed><social role><time use><transgenic><treatment strategy><two-photon>
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EVE E MARDER

BRANDEIS UNIVERSITY, WALTHAM, MA

Exploratory lead · 26/100
Likely hiring
$39,750
FY 2023

Project Title

Neuromodulation and Robustness of Neurons and Networks

Grant Number:

3R35NS097343-07S1

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

8/31/2024

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary / Abstract This R35 consolidated three ongoing NINDS-funded proposals that deal with neuromodulation (R37 NS 17813), temperature compensation (R01 NS 81012), and computational models of homeostatic regulation of intrinsic excitability (P01 NS07949). Together these projects comprise a...

Research Terms

<Address><Animals><Behavior><Biological><Brain><Brain Nervous System><Compensation><Computer Models><Computerized Models><Crustacea><Crustacean><Encephalon><Funding><Future><Ganglia><Goals><Human><Individual><Invertebrata><Invertebrates><Ion Channel><Ionic Channels><Measures><Membrane Channels><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Modeling><Modern Man><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neural Ganglion><Neurocyte><Neurologic Body System><Neurologic Organ System><Neuromodulator Receptors><Neurons><Receptor Protein><Regulation><Surface Proteins><Synapses><Synaptic><Temperature><Time><Work><biologic><computational modeling><computational models><computer based models><computerized modeling><experiment><experimental research><experimental study><experiments><flexibility><flexible><neural control><neural regulation><neuromodulation><neuromodulatory><neuronal><neuroregulation><receptor><response><synapse>
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Fuming Zhang

RENSSELAER POLYTECHNIC INSTITUTE, TROY, NY

Exploratory lead · 24/100
Large award
$1,198,520
FY 2023

Project Title

Orbitrap Eclipse Tribrid Mass Spectrometer as a Regional Resource

Grant Number:

1S10OD032168-01A1

Activity Code:

S10

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/5/2023

End Date:

9/4/2024

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

7. Project Summary/Abstract This S10 Shared Instrumentation Grant Proposal requests funds to acquire an Orbitrap Eclipse Tribrid mass spectrometer (MS). This new Orbitrap will replace our current LTQ Orbitrap XL MS and the TSQ Quantum Ultra MS, both more than 15 years old. This strategic investment ...

Research Terms

<15 year old><15 years of age><AD dementia><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Applications Grants><Biomanufacturing><Biomedical Engineering><Biophysics><Biotech><Biotechnology><Cancers><Capital><Cardiac><Cholesterol><Circadian Rhythms><Communities><Core Facility><Disease><Disorder><Ensure><Experimental Designs><Funding><Glomerular disease><Glycans><Grant Proposals><Human><Immune><Immunes><Interdisciplinary Research><Interdisciplinary Study><Investments><Lung><Lung Respiratory System><Maintenance><Malignant Neoplasms><Malignant Tumor><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Minor><Modern Man><Molecular><Multidisciplinary Collaboration><Multidisciplinary Research><NIH><National Institutes of Health><New York><Nyctohemeral Rhythm><Paralysis Agitans><Parkinson><Parkinson Disease><Peer Review><Phosphorylation><Play><Policies><Polysaccharides><Primary Parkinsonism><Primary Senile Degenerative Dementia><Protein Phosphorylation><Proteomics><Publications><Radial><Radius><Renal Glomerular Diseases and Syndromes><Renal glomerular disease><Renal glomerular disease or syndrome><Renal glomerular disorder><Renal glomerular syndrome><Request for Proposals><Research><Research Resources><Resources><Running><Sampling><Scientific Publication><Spinal Cord Trauma><Spinal Trauma><Spinal cord injured><Spinal cord injury><Technology><Time><Traumatic Myelopathy><Twenty-Four Hour Rhythm><United States National Institutes of Health><age 15 years><base><bases><bio-engineered><bio-engineers><bioengineering><biological engineering><biophysical foundation><biophysical principles><biophysical sciences><circadian process><cost><daily biorhythm><experience><experiment><experimental research><experimental study><experiments><fifteen year old><fifteen years of age><human disease><instrument><instrumentation><malignancy><mass spectrometer><microbiome><neoplasm/cancer><operation><operations><primary degenerative dementia><programs><pulmonary><quantum><senile dementia of the Alzheimer type><structural biology><success>
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Eric Padron

H. LEE MOFFITT CANCER CTR & RES INST, TAMPA, FL

Exploratory lead · 20/100
Solid budget
Active award
$477,698
FY 2025

Project Title

Developing and credentialing patient-derived xenograft models to advance therapeutic approaches for chronic myelomonocytic leukemia

Grant Number:

5R37CA234021-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/12/2019

End Date:

7/31/2026

Project Abstract

Project Summary/Abstract Chronic Myelomonocytic Leukemia (CMML) is a lethal subtype of leukemia characterized by cytopenias, marrow dysplasia, monocytosis, and a propensity for transformation to acute myeloid leukemia (AML). Until this R37 parent grant, no mouse model of CMML, to include genetically...

Research Terms

<AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Acute leukemia><Affect><Architecture><Assay><Binding><Bioassay><Biological><Biological Assay><Biology><Cell Body><Cells><Characteristics><Chromatin><Chronic><Chronic Myelomonocytic Leukemia><Clinical><Clinical Data><Clinical Trials><Clone Cells><Collaborations><Communication><Credentialing><Cytokine Signal Transduction><Cytokine Signaling><DNA Alteration><DNA Sequence Alteration><DNA mutation><Data><Dependence><Disease><Disorder><Dysplasia><Engineering / Architecture><Engraftment><GEM model><GEMM model><Gene Alteration><Gene Mutation><Genes><Genetic><Genetic Alteration><Genetic Change><Genetic defect><Genetic mutation><Genetically Engineered Mouse><Genotype><Goals><Hematopoietic Cell Tumor><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Heterograft><Heterologous Transplantation><Histologic><Histologically><Human><Human Characteristics><Human Nature><Hybrids><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><KO mice><Knock-out Mice><Knockout Mice><Leukemic Cell><Malignant Hematopoietic Neoplasm><Marrow><Marrow Mast Cell><Mast Cell Neoplasm><Mast Cell Proliferative Disease><Mast Cells Tumor><Mastocytoma><Messenger RNA><Mice><Mice Mammals><Modeling><Modern Man><Molecular Interaction><Monocytosis><Mouse Strains><Murine><Mus><Mutate><Mutation><Myeloid Disease><Myeloid Malignancy><Myeloid Neoplasm><Myeloid Tumor><Myeloproliferative Disorders><Myeloproliferative Tumors><Myeloproliferative disease><Natural History><Non-Polyadenylated RNA><Null Mouse><PDX model><Patient derived xenograft><Patients><Phase><Phenotype><Progenitor Cells><Proteome><RNA><RNA Gene Products><RNA Splicing><Recurrence><Recurrent><Resolution><Ribonucleic Acid><Sampling><Sequence Alteration><Signal Pathway><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Spliceosomes><Splicing><System><Testing><Therapeutic><Tissue Banks><Tissue Basophils><Tissue Collection><Tissue repository><Translating><Xenograft><Xenograft procedure><Xenotransplantation><acute granulocytic leukemia><acute myeloid leukemia><biologic><blood cancer><cancer of blood><cancer of the blood><curative intervention><curative therapeutic><curative therapy><curative treatments><cytokine><cytopenia><determine efficacy><disease model><disorder model><dyscrasia><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experience><gene defect><genetically engineered mouse model><genetically engineered murine model><genome mutation><genomic alteration><global gene expression><global transcription profile><hematopoietic differentiation><human disease><immunosuppressed patient><improved><in vivo><leukemia><mRNA><mast cell><mastocyte><mouse model><murine model><mutant><mutant allele><mutational status><myeloproliferative neoplasm><nanostring><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><non-genetic><nongenetic><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><parent grant><patient derived xenograft model><phase 2 study><phase II study><pre-clinical><preclinical><predict responsiveness><predicting response><prospective><resolutions><response><screening><screenings><stem cells><success><therapeutic target><transcriptome><xeno-transplant><xeno-transplantation>
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Oleh Taratula

OREGON STATE UNIVERSITY, CORVALLIS, OR

Exploratory lead · 20/100
Solid budget
Active award
$458,097
FY 2025

Project Title

Novel Nanomedicine-Based Therapeutic Approach For Treatment of Cancer Cachexia

Grant Number:

5R37CA234006-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

4/30/2027

Project Abstract

Project Summary Cachexia is a debilitating metabolic disorder that affects 50% of all cancer patients. Numerous clinical trials confirmed that the wasting of skeletal muscle mass is the hallmark of cachexia. During the course of the R37 parent grant, the research team developed the first messenger R...

Research Terms

<Activin-Binding Protein><Activins><Acyltransferase><Affect><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Appetite><Appetite stimulated><Applications Grants><Attenuated><Behavior><Behavioral><Binding><Blood Serum><Body Composition><Body Weight decreased><CD106><CD106 Antigens><CDDP><Cachectic><Cachexia><Cancer Cachexia><Cancer Model><Cancer Patient><Cancer Treatment><CancerModel><Cancers><Cause of Death><Cell Body><Cells><Circulation><Cis-diammine-dichloroplatinum><Cis-diamminedichloridoplatinum><Cis-diamminedichloro Platinum (II)><Cis-dichloroammine Platinum (II)><Cis-platinous Diamine Dichloride><Cis-platinum II><Cis-platinum II Diamine Dichloride><Cisplatin><Cisplatina><Cisplatinum><Clinical Trials><Code><Coding System><Consumption><Cysplatyna><Data><Desire for food><Dichlorodiammineplatinum><Differentiation and Growth><Disease><Disorder><Drugs><EC 2.3><EYDF><Eating><Embryonic Muscle Cells><Endocrine Gland Secretion><Endothelial Cells><Ensure><Exhibits><FSH-Releasing Protein><Fats><Fatty acid glycerol esters><Follistatin><Food Intake><Gene Delivery><Glycoproteins><Goals><Grant Proposals><Head and Neck Cancer><Head and Neck Carcinoma><Health><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Hormone secretion><Hormones><Human><Hypothalamic structure><Hypothalamus><INCAM-110><IRAK4><IRAK4 gene><Increased food appetite><Inducible Cell Adhesion Molecule 110><Inflammation><Inflammatory><Interleukin-1 Receptor-Associated Kinase 4><Intravenous><Investigators><Kupffer Cells><Leanness><Literature><Liver><Liver Cells><Lung><Lung Respiratory System><Malignant Cell><Malignant Head and Neck Neoplasm><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Ovarian Neoplasm><Malignant Ovarian Tumor><Malignant Tumor><Malignant Tumor of the Lung><Malignant Tumor of the Ovary><Malignant neoplasm of lung><Malignant neoplasm of ovary><Mediating><Medication><Messenger RNA><Metabolic><Metabolic Diseases><Metabolic Disorder><Metastasis><Metastasis to the Lung><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Lung><Metastatic Tumor><Metastatic Tumor to the Lung><Mice><Mice Mammals><Modeling><Modern Man><Molecular Interaction><Murine><Mus><Muscle Atrophy><Muscular Atrophy><Myoblasts><NY-REN-64><Nanoplatform><Nanotechnological platform><Neoplasm Metastasis><Nutritional Support><Ovary Cancer><PDA model><PDAC Model><Pancreas><Pancreas Ductal Adenocarcinoma><Pancreatic><Pancreatic Ductal Adenocarcinoma><Patients><Peptides><Persons><Peyrone's Chloride><Peyrone's Salt><Pharmaceutical Preparations><Phenotype><Platinum Diamminodichloride><Play><Pre-Clinical Model><Preclinical Models><Precursor Muscle Cells><Production><Proliferating><Proteins><Pulmonary Cancer><Pulmonary malignant Neoplasm><QOL><Quality of life><REN64><RNA based therapeutics><RNA based therapy><RNA therapy><Receptor Protein><Reporting><Research><Research Personnel><Researchers><Role><Route><Secondary Neoplasm><Secondary Tumor><Serum><Site><Skeletal Muscle><Solid Neoplasm><Solid Tumor><Stellate Sinusoidal Macrophage><Stomach><Subcutaneous Injections><Syndrome><System><Technology><Testing><Therapeutic><Therapeutic Agents><Therapeutic Hormone><Thesaurismosis><Thinness><Toxic effect><Toxicities><Treatment Efficacy><Treatment outcome><VCAM><VCAM-1><Vascular Cell Adhesion Molecule><Vascular Cell Adhesion Molecule-1><Voluntary Muscle><Weight Loss><Weight Reduction><Wild Type Mouse><activin A><antagonism><antagonist><anti-cancer therapy><appetite loss><attenuate><attenuates><body weight loss><cancer associated cachexia><cancer cell><cancer induced cachexia><cancer metastasis><cancer progression><cancer therapy><cancer-associated muscle wasting><cancer-directed therapy><cancer-induced muscle atrophy><cancer-induced muscle loss><cancer-induced muscle wasting><cancer-related cachexia><chemotherapy><cis dichlorodiammineplatinum><cis platinum compound><cis-Diaminedichloroplatinum><cis-Diamminedichloroplatinum><cis-Diamminedichloroplatinum(II)><cis-Dichlorodiammineplatinum(II)><cis-Platinum><deliver mRNA><deliver messenger RNA><delivery system for mRNA><design><designing><determine efficacy><differentiation factors><drug/agent><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><energy balance><erythroid differentiation factor><erythroid differentiation protein><evaluate efficacy><examine efficacy><gastric><ghrelin><head/neck cancer><hepatic body system><hepatic organ system><homo-activin A><hormonal secretion><hypothalamic><improved><increased appetite><increased hunger><inhibitor><intervention efficacy><intraperitoneal><intravenous administration><intravenous injection><lean body mass><lipid based nanoparticle><lipid nanoparticle><liver macrophage><lung cancer><lung metastasis><mRNA><mRNA delivery><malignancy><malignant ascites><malignant head and neck tumor><messenger RNA delivery><metabolism disorder><metastasize to the lung><morphogenic factors><morphogens><mouse model><murine model><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle wasting><nano medicinal><nano medicine><nano particle><nano particle delivery><nano polymer><nano-sized particle><nanomedicinal><nanomedicine><nanoparticle><nanoparticle delivered><nanoparticle delivery><nanopolymer><nanosized particle><nanotechnology platform><neoplasm progression><neoplasm/cancer><neoplastic progression><novel><nutritional care><nutritional therapy><ovarian cancer><overexpress><overexpression><pancreatic cancer model><pancreatic ductal adenocarcinoma model><pancreatic tumor model><parent grant><pharmacologic><physical impairment><pre-clinical study><preclinical study><preservation><prevent><preventing><pulmonary metastasis><receptor><skeletal muscle atrophy><skeletal muscle breakdown><skeletal muscle loss><skeletal muscle protein loss><skeletal muscle wasting><skeletal preservation><social role><subcutaneous><subdermal><subdermal injection><systemic inflammation><systemic inflammatory response><therapeutic RNA><therapeutic efficacy><therapy efficacy><translational opportunities><translational potential><translational therapeutics><translational therapy><tumor><tumor cell metastasis><tumor progression><tumor-induced cachexia><tumor-induced muscle wasting><validation studies><wildtype mouse><wt-loss>
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Thirumala-Devi Kanneganti

ST. JUDE CHILDREN'S RESEARCH HOSPITAL, MEMPHIS, TN

Exploratory lead · 20/100
Solid budget
Active award
$455,000
FY 2025

Project Title

Inflammatory Caspases in Innate Immunity and Inflammation

Grant Number:

5R37AI101935-14

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2012

End Date:

4/30/2027

Project Abstract

ABSTRACT Aspergillus fumigatus (A. fumigatus) is an important human fungal pathogen which is responsible for significant morbidity and mortality, particularly among immunocompromised patients. In recent years, we have made important progress in understanding the molecular mechanisms that regulate ...

Research Terms

<A fumigatus><A. fumigatus><Apoptosis><Apoptosis Pathway><Apoptosis-Related Cysteine Protease Caspase 1><Applications Grants><Area><Aspergillus fumigatus><Automobile Driving><Beta Proprotein Interleukin 1><Biochemical><CASP-1><CASP1><CASP1 gene><CRISPR><CRISPR/Cas system><Caspase><Caspase Gene><Caspase-1><Caspase-1 Gene><Cell Body><Cell Communication and Signaling><Cell Death><Cell Signaling><Cell-Death Protease><Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Complex><Computational toolkit><Cysteine Endopeptidases><Cysteine Protease><Cysteine Proteinases><Cytoplasm><Family><Funding><Fungus Diseases><Genes><Genetic><Genome><Grant Proposals><Host Defense><Human><ICE Protease><ICE-like protease><IFN-Gamma-Inducing Factor Gene><IFN-gamma-Inducing Factor><IGIF><IGIF Gene><IL-1 Gamma><IL-1 Gamma Gene><IL-1 beta><IL-1 beta Convertase><IL-1 beta-Converting Enzyme><IL-1 β><IL-1-b><IL-18><IL-18 Gene><IL-1BC><IL-1b Converting Enzyme><IL-1g><IL-1g Gene><IL-1β><IL1-Beta><IL1-β><IL18><IL18 Protein><IL18 gene><IL1B Protein><IL1B-Convertase><IL1BC><IL1BCE><IL1F2><IL1F4><IL1F4 Gene><IL1β><Immune><Immune Precipitation><Immune response><Immune signaling><Immunes><Immunity><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunology><Immunoprecipitation><Immunosuppressed Host><Individual><Infection><Inflammasome><Inflammation><Inflammatory><Influenza A><Influenza A virus><Influenza Viruses Type A><Influenzavirus A><Innate Immunity><Interferon-Gamma-Inducing Factor Gene><Interferon-gamma-Inducing Factor><Interleukin 1-B Converting Enzyme><Interleukin 1-Beta Convertase><Interleukin 18 (Interferon-Gamma-Inducing Factor)><Interleukin 18 (Interferon-Gamma-Inducing Factor) Gene><Interleukin 18 Proprotein><Interleukin 18 Proprotein Gene><Interleukin 1beta><Interleukin-1 Beta Converting Enzyme><Interleukin-1 Converting Enzyme><Interleukin-1 Gamma><Interleukin-1 Gamma Gene><Interleukin-1 beta><Interleukin-18><Interleukin-18 Precursor><Interleukin-18 Precursor Gene><Interleukin-1β><Intracellular Communication and Signaling><KO mice><Knock-out Mice><Knockout Mice><Laboratories><MGC12320><MGC12320 Gene><Macromolecular Protein Complexes><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Microbiology><Modeling><Modern Man><Molecular><Morbidity><Morbidity - disease rate><Mouse Strains><Multiprotein Complexes><Mycoses><NGS Method><NGS system><Native Immunity><Natural Immunity><Nature><Non-Specific Immunity><Nonspecific Immunity><Null Mouse><Orthomyxovirus Type A><Paper><Pathway interactions><Pattern recognition receptor><Peer Review><Play><Position><Positioning Attribute><Preinterleukin 1 Beta><Programmed Cell Death><Proteomics><Publications><Receptor Protein><Research><Role><Scientific Publication><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><System><TLR protein><Techniques><Testing><Therapeutic Intervention><Toll-Like Receptor Family Gene><Toll-like receptors><Type A Influenza><Z-DNA Binding Protein><biological signal transduction><computational toolbox><computational tools><computational toolset><computerized tools><cystein protease><cystein proteinase><cysteine endopeptidase><cytokine><driving><entire genome><experiment><experimental research><experimental study><experiments><full genome><fungal infection><fungal pathogen><fungi pathogen><fungus infection><galactosaminogalactan><genetic approach><genetic strategy><host response><immune system response><immunoresponse><immunosuppressed patient><in vivo><intervention therapy><member><mortality><necrocytosis><next gen sequencing><next generation sequencing><nextgen sequencing><novel><pathogen><pathogenic fungus><pathway><receptor><response><scaffold><scaffolding><screening><screenings><sensor><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><whole genome>
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RUSSELL E VANCE

UNIVERSITY OF CALIFORNIA BERKELEY, BERKELEY, CA

Exploratory lead · 20/100
Solid budget
Active award
$449,050
FY 2025

Project Title

Functional and Structural Dissection of Inflammasome Activation

Grant Number:

5R37AI075039-18

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2008

End Date:

6/30/2028

Project Abstract

This is a MERIT extension of R37 AI075039. In the previous funding period we addressed the fundamental mechanisms by which pathogen-encoded virulence activities are detected by the innate immune system. We focused on an innate immune sensor called the NLRP1 inflammasome. This sensor was known to be ...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><Address><B anthracis><B. anthracis><Bacillus anthracis><C-terminal><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Detection><Dissection><E3 Ligase><E3 Ubiquitin Ligase><Esteroproteases><Funding><Health><Human><Immune><Immune response><Immunes><Inflammasome><Innate Immune System><Instruction><Intracellular Communication and Signaling><LeTx><Macropain><Macroxyproteinase><Modern Man><Molecular><Multicatalytic Proteinase><Pathogenicity Factors><Peptidases><Peptide Hydrolases><Process><Prosome><Protease Gene><Proteases><Proteasome><Proteasome Endopeptidase Complex><Proteinases><Proteolytic Enzymes><Proteosome><S flexneri><S. flexneri><Shigella flexneri><Signal Transduction><Signal Transduction Systems><Signaling><Toxin><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Virulence><Virulence Factors><Work><anthracis><bacteria pathogen><bacterial pathogen><biological signal transduction><host response><immune system response><immunoresponse><innate immune sensing><lethal factor><lethal toxin><microbe pathogen><microbial pathogen><multicatalytic endopeptidase complex><novel><pathogen><pathogenic bacteria><pathogenic microbe><sensor><ubiquitin-protein ligase>
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Carolyn Bertozzi

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 20/100
Solid budget
Active award
$441,023
FY 2025

Project Title

Chemical Mycobateriology

Grant Number:

5R37AI051622-24

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2021

End Date:

8/31/2026

Project Abstract

Tuberculosis (TB) is a chronic pulmonary disease caused by Mycobacterium tuberculosis (Mtb), which infects approximately one quarter of the world’s population. A variety of drugs have been identified that rapidly kill Mtb and its relatives in vitro, yet clinical treatment requires at least 6 months ...

Research Terms

<Adamantane><Address><Affinity><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antigens><Antitubercular Drugs><Bacteria><Bacterial Infections><Biological><Biology><Brachydanio rerio><Cell Body><Cell Culture Techniques><Cell Survival><Cell Viability><Cells><Chemicals><Chronic lung disease><Clinical><Clinical Treatment><Collaborations><Coloring Agents><Combined Modality Therapy><Complex><Danio rerio><Detection><Development><Diagnostic Reagent><Diamantane><Drug Screening><Drug Therapy><Drugs><Dyes><Fluorescence><Frustration><Funding><Generalized Growth><Generations><Genetic><Glean><Grant><Growth><HIV/Mtb><HIV/TB><HIV/mycobacterium tuberculosis><HIV/tuberculosis><Hour><Image><In Vitro><Infection><Innate Immunity><Instruction><Investigation><Knock-out><Knockout><Label><Libraries><Lipids><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><M marinum><M tb><M tuberculosis><M tuberculosis infection><M. marinum><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M. tuberculosis/HIV><M.tb infection><M.tuberculosis infection><MTB infection><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Medication><Membrane><Metabolic><Methods><Microscope><Microscopy><Miscellaneous Antibiotic><Modeling><Molecular><Multimodal Therapy><Multimodal Treatment><Mycobacterial Infection><Mycobacterium Infections><Mycobacterium marinum><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Participant><Patients><Performance><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Population><Protocol><Protocols documentation><Proxy><Reagent><Regimen><Resistance><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Role><Sampling><South Africa><Sputum><Structure><System><TB diagnosis><TB drugs><TB infection><TB therapy><TB treatment><Time><Tissue Growth><Trehalose><Tuberculosis><Tuberculosis diagnosis><Virulence><Visualization><Work><Zebra Danio><Zebra Fish><Zebrafish><active method><active technique><active treatment><analog><anti-TB drugs><anti-tuberculosis drugs><bacteria infection><bacterial disease><biologic><cell culture><cell cultures><chronic pulmonary disease><clinical intervention><clinical therapy><combination therapy><combined modality treatment><combined treatment><cost><detection method><detection procedure><detection technique><developmental><diagnosed with TB><diagnosed with Tuberculosis><disseminated TB><disseminated tuberculosis><drug intervention><drug treatment><drug/agent><ebselen><global health><high-throughput drug screening><imaging><immunogen><infection due to Mycobacterium tuberculosis><inhibitor><insight><magnetic beads><membrane structure><model organism><mtb><multi-modal therapy><multi-modal treatment><mycobacterial><next generation><nile red><ontogeny><pathogen><performance tests><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><point of care><point-of-care diagnostics><resistant><screening><screenings><social role><supply chain><treat M. tuberculosis><treat Mtb><treat Mycobacterium tuberculosis><treat tb><treat tuberculosis><trial regimen><trial treatment><tuberculosis drugs><tuberculosis infection><tuberculosis therapy><tuberculosis treatment><tuberculous spondyloarthropathy>
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Jennifer Tsui

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Exploratory lead · 20/100
Solid budget
Active award
$404,861
FY 2025

Project Title

Advancing the implementation of evidence-based strategies for HPV vaccination in safety-net primary care settings

Grant Number:

5R37CA242541-06

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/20/2020

End Date:

4/30/2027

Project Abstract

ABSTRACT HPV vaccination rates remain below target levels among adolescents in the United States, which is particularly concerning in safety-net populations with persistent disparities in HPV-associated cancer burden. There are numerous evidence-based strategies (EBS) designed to encourage HPV vacc...

Research Terms

<Acceleration><Address><Adolescent><Adolescent Youth><Adoption><Advocate><Area><Award><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cancer Burden><Cell Communication and Signaling><Cell Signaling><Clinic><Clinical><Communities><Complex><County><Data><Disparities><Disparity><Ensure><Equity><Ethnography><Funding><HPV Vaccination><HPV Vaccine><HPV caused cancer><HPV driven cancers><HPV induced cancer><HPV malignancy><HPV vaccination acceptability><HPV vaccination acceptance><HPV vaccination confidence><HPV vaccination uptake><HPV vaccine acceptability><HPV vaccine acceptance><HPV vaccine confidence><HPV vaccine uptake><HPV+ cancer><HPV-High Risk><HPV-Related Malignancy><HPV-associated cancer><HPV-associated malignancy><HPV-related cancer><Health Care><Health Care Systems><Health Services><Health system><High Risk Oncogenic HPV><High risk HPV><High risk Human Papillomavirus><High risk Human papilloma virus><History><Hospitals><Human Papilloma Virus Vaccination><Human Papilloma Virus Vaccine><Human Papilloma Virus-Related Malignancy><Human Papilloma Virus-Related Malignant Neoplasm><Human Papilloma Virus-associated cancer><Human Papilloma Virus-associated malignancy><Human Papilloma Virus-related cancer><Human Papillomavirus Vaccination><Human papillomavirus Vaccine><Human papillomavirus cancer><Human papillomavirus induced cancer><Human papillomavirus malignancy><Human papillomavirus-Related Malignancy><Human papillomavirus-Related Malignant Neoplasm><Hybrids><Intervention><Intracellular Communication and Signaling><Knowledge><Leadership><Los Angeles><Low income><Maintenance><Measures><Methods><Modeling><National Cancer Burden><New Jersey><Outcome><Parents><Personalized medical approach><Physicians><Policies><Population><Primary Care><Procedures><Process><Provider><Qualifying><RE-AIM><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Recording of previous events><Research><Research Resources><Resources><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Sampling><Science><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Signal Transduction><Signal Transduction Systems><Signaling><Site><System><Time><Training><Translating><Underinsured><Underserved Population><United States><Work><accept HPV vaccination><accept HPV vaccine><accept human papilloma virus vaccination><accept human papilloma virus vaccine><access to vaccination><access to vaccines><biological signal transduction><clinician communication><communicate to clinicians><communicate to providers><communicate with clinicians><communicate with doctors><communicate with providers><community marginalization><concept mapping><concept maps><context for implementation><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><design><designing><doctor communication><ethnographic><evidence base><health care settings><histories><hrHPV><human papilloma virus vaccination acceptability><human papilloma virus vaccination acceptance><human papilloma virus vaccination confidence><human papilloma virus vaccination uptake><human papilloma virus vaccine acceptability><human papilloma virus vaccine acceptance><human papilloma virus vaccine confidence><human papilloma virus vaccine uptake><human papillomavirus associated malignancy><human papillomavirus caused cancer><human papillomavirus driven cancers><human papillomavirus-associated cancer><human papillomavirus-related cancer><implementation context><implementation process><implementation science><implementation strategy><improved><individualized approach><juvenile><juvenile human><marginalized community><member><multidisciplinary><parent><parent award><parent project><personalized approach><practice setting><pragmatic effectiveness trial><pragmatic trial><precision approach><primary care setting><programs><provider communication><reach, efficacy, adoption, implementation, and maintenance><research study><safety net><scale up><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><strategies for implementation><tailored approach><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><uptake><vaccination access><vaccination availability><vaccine access><vaccine availability>
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Daniel Ellis Hyer

UNIVERSITY OF IOWA, IOWA CITY, IA

Exploratory lead · 20/100
Solid budget
Active award
$395,858
FY 2024

Project Title

Sharpening the edge in pencil-beam proton therapy: an aftermarket collimation system to better spare normal tissue during radiation treatment

Grant Number:

5R37CA226518-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2018

End Date:

8/31/2026

Project Abstract

Abstract/Summary Proton arc therapy has lagged behind photon arc therapy, which is now commonplace in the clinic, due mostly to slow proton energy switching times which make treatment durations impractical. Fast energy modulation systems are now clinically available, and, by applying delivery optimi...

Research Terms

<Acceleration><Acute Radiation Syndrome><Air><Algorithms><Area><Benchmarking><Best Practice Analysis><Body Tissues><Brain><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><Cancer Patient><Cancers><Childhood><Clinic><Clinical><Collimation><Collimator><Computational Technique><Data><Development><Devices><Distal><Dose><Encephalon><Ensure><Equipment><Feedback><Foundations><Goals><H+ element><HNC patient><Head and Neck Neoplasms><Hydrogen Ions><Individual><Industrialization><Inferior><Intercept><Ions><Lateral><Malignant Neoplasms><Malignant Tumor><Marketing><Measurement><Measures><Mechanics><Methodology><Methods><Mission><Modeling><Monitor><Motion><Normal Tissue><Normal tissue morphology><Outcome><Parents><Patients><Photons><Planning Methodology><Planning Technic><Planning Techniques><Plant Leaves><Position><Positioning Attribute><Predisposition><Protons><Public Health><QOC><QOL><Quality of Care><Quality of life><Radiation Dose><Radiation Dose Unit><Radiation Toxicity><Radiation therapy><Radiotherapeutics><Radiotherapy><Radiotoxicity><Research><Risk Reduction><Rotation><Scanning><Speed><Spottings><Surface><Susceptibility><System><Techniques><Technology><Testing><Time><Tissues><Translating><Treatment Efficacy><Treatment Period><Treatment outcome><Uncertainty><Validation><Work><benchmark><brain tissue><care delivery><clinical care><commercialization><cost><cost effective><design><designing><developmental><doubt><fighting><head and neck cancer patient><head and neck tumor><improved><in silico><innovate><innovation><innovative><intervention efficacy><leaf><malignancy><mechanic><mechanical><neoplasm/cancer><new technology><next generation><novel technologies><parent><pediatric><preservation><proton beam><proton therapy><prototype><quality assurance><radiation poisoning><radiation treatment><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk-reducing><side effect><technology platform><technology system><therapeutic efficacy><therapy efficacy><tool><treatment days><treatment duration><treatment planning><treatment with radiation><tumor><tumors in the brain><validations>
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Yong Chen

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 20/100
Solid budget
Active award
$395,685
FY 2025

Project Title

Academic-Industry Partnership for the Translation of a 4D in vivo Dosimetry Approach for Radiation Therapy

Grant Number:

5R37CA240806-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2019

End Date:

8/31/2026

Project Abstract

NIH Merit Award (R37) extension request-R37CA240806, Xiang, (Shawn) Liangzhong The Overall Objective of this application is to enable in vivo dosimetry during radiation therapy in cancer patient to the end-user– the medical physicist. Our Hypothesis is that X-ray-induced Acoustic Computed tomography...

Research Terms

<3-D><3-Dimensional><3D><Acoustics><Award><Body Tissues><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><California><Cancer Patient><Cancer Treatment><Cancers><Cause of Death><Cell Communication and Signaling><Cell Signaling><Clinic><Clinical><Computed Tomography><Computed Tomography Scanners><Computer Simulation><Computer based Simulation><Dedications><Detection><Dose><Echography><Echotomography><Electrical Engineering><Elements><Ensure><Feedback><Frequencies><Goals><Health Sciences><History><Hydrogen Oxide><IMRT><Image><Imaging Device><Imaging Instrument><Imaging Procedures><Imaging Technics><Imaging Techniques><Imaging Tool><Inpatients><Intellectual Property><Intensity Modulated RT><Intensity Modulated Radiation Therapy><Intensity-Modulated Radiotherapy><Intervention><Intracellular Communication and Signaling><Investigation><Ions><Linear Accelerator><Linear Accelerator Radiotherapy Systems><Location><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Maps><Measurement><Medical><Medical Ultrasound><Modality><Monitor><NIH><National Institutes of Health><Oklahoma><Outcome><Patients><Performance><Photons><Physiologic pulse><Position><Positioning Attribute><Prostate><Prostate Gland><Prostatic Gland><Public Health><Pulse><Radiation><Radiation Dose><Radiation Dose Unit><Radiation Dosimetry><Radiation Oncologist><Radiation therapy><Radiometry><Radiotherapeutics><Radiotherapy><Recording of previous events><Research><Resolution><Roentgen Rays><Safety><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Speed><System><Techniques><Technology><Testing><Time><Tissues><Tomodensitometry><Transducers><Translating><Translations><Treatment-related toxicity><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><United States National Institutes of Health><Universities><Visualization><Water><Work><X-Radiation><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><X-Ray Radiation><X-ray><Xray><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><absorption><anti-cancer therapy><biological signal transduction><cancer therapy><cancer-directed therapy><catscan><clinical implementation><clinical translation><clinically translatable><common treatment><computational simulation><computed axial tomography><computer tomography><computerized axial tomography><computerized simulation><computerized tomography><design and construct><design and construction><detector><diagnostic ultrasound><dose information><dosimetry><experience><histories><imaging><imaging capabilities><imaging system><improved><in vivo><industrial partnership><industry partner><industry partnership><innovate><innovation><innovative><instrumentation><malignancy><neoplasm/cancer><new technology><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel><novel technologies><product development><prototype><radiation treatment><radioassay><real time monitoring><real-time images><realtime image><realtime monitoring><resolutions><simulation><soft tissue><sonogram><sonography><sound measurement><spatial and temporal><spatial temporal><spatiotemporal><success><temporal measurement><temporal resolution><therapeutic toxicity><therapy associated toxicity><therapy related toxicity><therapy toxicity><three dimensional><time measurement><tool><translation><treatment toxicity><treatment with radiation><treatment-associated toxicity><tumor><ultrasound><ultrasound imaging><ultrasound scanning>
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Vassili Ivanov

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 20/100
Solid budget
Active award
$395,685
FY 2025

Project Title

Academic-Industry Partnership for the Translation of a 4D in vivo Dosimetry Approach for Radiation Therapy

Grant Number:

5R37CA240806-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2019

End Date:

8/31/2026

Project Abstract

NIH Merit Award (R37) extension request-R37CA240806, Xiang, (Shawn) Liangzhong The Overall Objective of this application is to enable in vivo dosimetry during radiation therapy in cancer patient to the end-user– the medical physicist. Our Hypothesis is that X-ray-induced Acoustic Computed tomography...

Research Terms

<3-D><3-Dimensional><3D><Acoustics><Award><Body Tissues><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><California><Cancer Patient><Cancer Treatment><Cancers><Cause of Death><Cell Communication and Signaling><Cell Signaling><Clinic><Clinical><Computed Tomography><Computed Tomography Scanners><Computer Simulation><Computer based Simulation><Dedications><Detection><Dose><Echography><Echotomography><Electrical Engineering><Elements><Ensure><Feedback><Frequencies><Goals><Health Sciences><History><Hydrogen Oxide><IMRT><Image><Imaging Device><Imaging Instrument><Imaging Procedures><Imaging Technics><Imaging Techniques><Imaging Tool><Inpatients><Intellectual Property><Intensity Modulated RT><Intensity Modulated Radiation Therapy><Intensity-Modulated Radiotherapy><Intervention><Intracellular Communication and Signaling><Investigation><Ions><Linear Accelerator><Linear Accelerator Radiotherapy Systems><Location><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Maps><Measurement><Medical><Medical Ultrasound><Modality><Monitor><NIH><National Institutes of Health><Oklahoma><Outcome><Patients><Performance><Photons><Physiologic pulse><Position><Positioning Attribute><Prostate><Prostate Gland><Prostatic Gland><Public Health><Pulse><Radiation><Radiation Dose><Radiation Dose Unit><Radiation Dosimetry><Radiation Oncologist><Radiation therapy><Radiometry><Radiotherapeutics><Radiotherapy><Recording of previous events><Research><Resolution><Roentgen Rays><Safety><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Speed><System><Techniques><Technology><Testing><Time><Tissues><Tomodensitometry><Transducers><Translating><Translations><Treatment-related toxicity><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><United States National Institutes of Health><Universities><Visualization><Water><Work><X-Radiation><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><X-Ray Radiation><X-ray><Xray><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><absorption><anti-cancer therapy><biological signal transduction><cancer therapy><cancer-directed therapy><catscan><clinical implementation><clinical translation><clinically translatable><common treatment><computational simulation><computed axial tomography><computer tomography><computerized axial tomography><computerized simulation><computerized tomography><design and construct><design and construction><detector><diagnostic ultrasound><dose information><dosimetry><experience><histories><imaging><imaging capabilities><imaging system><improved><in vivo><industrial partnership><industry partner><industry partnership><innovate><innovation><innovative><instrumentation><malignancy><neoplasm/cancer><new technology><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel><novel technologies><product development><prototype><radiation treatment><radioassay><real time monitoring><real-time images><realtime image><realtime monitoring><resolutions><simulation><soft tissue><sonogram><sonography><sound measurement><spatial and temporal><spatial temporal><spatiotemporal><success><temporal measurement><temporal resolution><therapeutic toxicity><therapy associated toxicity><therapy related toxicity><therapy toxicity><three dimensional><time measurement><tool><translation><treatment toxicity><treatment with radiation><treatment-associated toxicity><tumor><ultrasound><ultrasound imaging><ultrasound scanning>
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Shawn Liangzhong Xiang

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 20/100
Solid budget
Active award
$395,685
FY 2025

Project Title

Academic-Industry Partnership for the Translation of a 4D in vivo Dosimetry Approach for Radiation Therapy

Grant Number:

5R37CA240806-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2019

End Date:

8/31/2026

Project Abstract

NIH Merit Award (R37) extension request-R37CA240806, Xiang, (Shawn) Liangzhong The Overall Objective of this application is to enable in vivo dosimetry during radiation therapy in cancer patient to the end-user– the medical physicist. Our Hypothesis is that X-ray-induced Acoustic Computed tomography...

Research Terms

<3-D><3-Dimensional><3D><Acoustics><Award><Body Tissues><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><California><Cancer Patient><Cancer Treatment><Cancers><Cause of Death><Cell Communication and Signaling><Cell Signaling><Clinic><Clinical><Computed Tomography><Computed Tomography Scanners><Computer Simulation><Computer based Simulation><Dedications><Detection><Dose><Echography><Echotomography><Electrical Engineering><Elements><Ensure><Feedback><Frequencies><Goals><Health Sciences><History><Hydrogen Oxide><IMRT><Image><Imaging Device><Imaging Instrument><Imaging Procedures><Imaging Technics><Imaging Techniques><Imaging Tool><Inpatients><Intellectual Property><Intensity Modulated RT><Intensity Modulated Radiation Therapy><Intensity-Modulated Radiotherapy><Intervention><Intracellular Communication and Signaling><Investigation><Ions><Linear Accelerator><Linear Accelerator Radiotherapy Systems><Location><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Maps><Measurement><Medical><Medical Ultrasound><Modality><Monitor><NIH><National Institutes of Health><Oklahoma><Outcome><Patients><Performance><Photons><Physiologic pulse><Position><Positioning Attribute><Prostate><Prostate Gland><Prostatic Gland><Public Health><Pulse><Radiation><Radiation Dose><Radiation Dose Unit><Radiation Dosimetry><Radiation Oncologist><Radiation therapy><Radiometry><Radiotherapeutics><Radiotherapy><Recording of previous events><Research><Resolution><Roentgen Rays><Safety><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Speed><System><Techniques><Technology><Testing><Time><Tissues><Tomodensitometry><Transducers><Translating><Translations><Treatment-related toxicity><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><United States National Institutes of Health><Universities><Visualization><Water><Work><X-Radiation><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><X-Ray Radiation><X-ray><Xray><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><absorption><anti-cancer therapy><biological signal transduction><cancer therapy><cancer-directed therapy><catscan><clinical implementation><clinical translation><clinically translatable><common treatment><computational simulation><computed axial tomography><computer tomography><computerized axial tomography><computerized simulation><computerized tomography><design and construct><design and construction><detector><diagnostic ultrasound><dose information><dosimetry><experience><histories><imaging><imaging capabilities><imaging system><improved><in vivo><industrial partnership><industry partner><industry partnership><innovate><innovation><innovative><instrumentation><malignancy><neoplasm/cancer><new technology><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel><novel technologies><product development><prototype><radiation treatment><radioassay><real time monitoring><real-time images><realtime image><realtime monitoring><resolutions><simulation><soft tissue><sonogram><sonography><sound measurement><spatial and temporal><spatial temporal><spatiotemporal><success><temporal measurement><temporal resolution><therapeutic toxicity><therapy associated toxicity><therapy related toxicity><therapy toxicity><three dimensional><time measurement><tool><translation><treatment toxicity><treatment with radiation><treatment-associated toxicity><tumor><ultrasound><ultrasound imaging><ultrasound scanning>
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Jeremy James Johnson

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Exploratory lead · 20/100
Solid budget
Active award
$371,679
FY 2025

Project Title

Defining the role of isoprenylated xanthones from the mangosteen for enhancing degradation of full length and variant forms of androgen receptor in prostate cancer

Grant Number:

5R37CA227101-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2019

End Date:

4/30/2027

Project Abstract

PROJECT SUMMARY Clinically there are examples of small molecules including finasteride and dutasteride that can reduce the risk of prostate cancer and potentially may be effect in minimal low risk disease. AR targeting drugs can prove extremely beneficial for a patient, however, the benefit is short...

Research Terms

<5 alpha-Dihydrotestosterone><5-alpha-DHT><70-kD Heat-Shock Protein><9-Oxoxanthene><Androgen Antagonists><Androgen Receptor><Androstanolone><Animal Model><Animal Models and Related Studies><Anti-Androgen><Anti-Androgen Agents><Anti-Estrogens><Apoptosis><Apoptosis Pathway><Apoptotic><Applications Grants><Automobile Driving><Award><Benign><BiP gene><BiP protein><Binding><Binding Proteins><Biological><Breast Cancer><Castration><Cell Body><Cell Nucleus><Cell surface><Cells><Chaperone><Chemicals><Chemoprevention><Chibro-Proscar><Clinical><Clinical Trials><Creativeness><Data><Development><Dihydrotestosterone><Dimerization><Diterpenes><Diterpenoids><Dose><Drug Kinetics><Drug Targeting><Drugs><Dutasteride><ER stress><Early Diagnosis><Enzyme Gene><Enzymes><Epithelial Cells><Epithelium of Human Prostate Gland><Estrogen Antagonists><Evaluation><FDA approved><Finasteride><Finastid><Fostering><Fruit><Future><GRP78><GRP78 gene><Garcinia mangostana><Genetic Polymorphism><Glucose-Regulated Protein, 78-kD><Goals><Grant Proposals><HSP 70><HSP70><HSPA5><Health><Heat-Shock 70-kD Protein 5><Heat-Shock Proteins 70><Heterograft><Heterologous Transplantation><Immunoglobulin Binding Factor><Immunoglobulin binding proteins><In Vitro><Individual><Kinases><Length><Ligand Binding Protein><Ligand Binding Protein Gene><Ligands><Malignant Breast Neoplasm><Malignant neoplasm of prostate><Malignant prostatic tumor><Mangosteen><Medication><Mice><Mice Mammals><Microsomes><Mission><Molecular><Molecular Chaperones><Molecular Interaction><Murine><Mus><NIH><National Institutes of Health><Natural Products Chemistry><Nuclear Translocation><Nucleus><Oral Administration><Oral Drug Administration><PC-3><PC-3 cell line><PC3><PC3 cell line><Pathway interactions><Patients><Pharmaceutical Preparations><Pharmacokinetics><Phenotype><Phosphotransferase Gene><Phosphotransferases><Prevention><Programmed Cell Death><Proliferating><Propecia><Property><Propeshia><Proscar><Prostate CA><Prostate CA therapy><Prostate Cancer><Prostate Cancer therapy><Prostate malignancy><Prostatic Epithelium><Prostide><Protein Binding><Protein Dimerization><Proteins><Public Health><RNA Splicing><Receptor Protein><Recombinants><Research><Resistance><Resistance development><Resistant development><Risk Reduction><Role><Source><Splicing><Stanolone><Structure-Activity Relationship><Surgical Castration><TRAMP mouse><Testing><Therapeutic><Therapeutic Androstanolone><Transfection><Transgenic Animals><Transphosphorylases><United States National Institutes of Health><Urprosan><Variant><Variation><Xanthones><Xenograft><Xenograft procedure><Xenotransplantation><Xtandi><abiraterone><androgen independent prostate cancer><androgen indifferent prostate cancer><androgen inhibitor><androgen insensitive prostate cancer><androgen resistance in prostate cancer><androgen resistant prostate cancer><androgenic><antiestrogen><antiestrogenic><biologic><bound protein><cancer chemoprevention><castration resistant CaP><castration resistant PCa><castration resistant prostate cancer><chemical structure function><creativity><determine efficacy><developing resistance><developmental><dietary><dietary fruit><disease risk><disorder risk><driving><drug/agent><early detection><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><endoplasmic reticulum stress><enzalutamide><estrogen inhibitor><evaluate efficacy><examine efficacy><hormone refractory prostate cancer><hsp70 Family><immunoglobulin heavy chain-binding protein><improved><in vivo><innovate><innovation><innovative><intraoral drug delivery><isoprenylation><malignant breast tumor><men><model of animal><mouse model><murine model><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><parent grant><pathway><polymorphism><prevent><preventing><prostate cancer cell><prostate cancer resistant to androgen><prostate cancer risk><prostate cancer treatment><prostate carcinogenesis><prostate tumor cell><prostate tumorigenesis><receptor><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resistant><risk-reducing><side effect><small molecule><social role><structure function relationship><transgenic adenocarcinoma of mouse prostate><treatment strategy><xeno-transplant><xeno-transplantation>
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Kathrin Milbury

UNIVERSITY OF TX MD ANDERSON CAN CTR, HOUSTON, TX

Exploratory lead · 20/100
Solid budget
Active award
$365,817
FY 2024

Project Title

Dyadic yoga Program for Patients with Lung Cancer Undergoing Radiotherapy and their Family Caregivers

Grant Number:

4R37CA231522-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT Patients with lung cancer, on the most prevalent cancer diagnoses in the United States, tend to experience debilitating physical and psychological sequelae. Common symptoms include reduced lung function, dyspnea, fatigue, sleep disturbances, and depression compromising their...

Research Terms

<Address><Breathlessness><Burden on their caregivers><CCOP><CCSG><Cancer Cause><Cancer Center Support Grant><Cancer Etiology><Cancer Patient><Care Givers><Caregiver Burden><Caregivers><Caring><Cessation of life><Chest><Communities><Community Care Networks><Community Clinical Oncology Program><Community Oncology><Core Facility><Correlation Studies><Data><Death><Detection><Development><Disease><Disorder><Disparities><Disparity><Dyspnea><Eligibility><Eligibility Determination><Emotional><Family><Family Care Giver><Family Caregiver><Family member><Fatigue><Feedback><Female><Funding><Goals><High Prevalence><Intervention><Intervention Strategies><Knowledge><Lack of Energy><Low income><Malignant Tumor of the Lung><Malignant neoplasm of lung><Measurement><Mental Depression><Methods><Minority><NSCLC><NSCLC - Non-Small Cell Lung Cancer><Non-Small Cell Lung Cancer><Non-Small-Cell Lung Carcinoma><Outcome><Outcome Study><Parents><Participant><Patient Care><Patient Care Delivery><Patient Triage><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Persons><Physical Function><Play><Population><Process><Protocol Screening><Pulmonary Cancer><Pulmonary malignant Neoplasm><QOC><QOL><Qualitative Methods><Quality of Care><Quality of life><Radiation therapy><Radiotherapeutics><Radiotherapy><Randomized, Controlled Trials><Recontacts><Reporting><Research><Resource Sharing><Risk Factors><Role><Schedule><Single-Blind Study><Single-blind><Sleep disturbances><Source><Statistical Correlation><Suggestion><Supportive Therapy><Supportive care><Taxes><Testing><Thorace><Thoracic><Thorax><Time><United States><Vulnerable Populations><Work><Yoga><aberrant sleep><burden in caregivers><burden of their caregivers><burden on caregivers><cancer diagnosis><care for patients><care giving><care of patients><caregiver quality of life><caregiving><caring for patients><clinical care><common symptom><community setting><comparator group><comparison group><cost effective><depression><design><designing><determine efficacy><developmental><disrupted sleep><disturbed sleep><effectiveness testing><effectiveness trial><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy trial><evaluate efficacy><evidence base><examine efficacy><experience><field based data><field learning><field study><field test><flexibility><flexible><formative assessment><formative evaluation><future implementation><impaired sleep><implementation research><improved><innovate><innovation><innovative><instructor><intervention delivery><interventional strategy><irregular sleep><lung cancer><lung function><male><mobile app><mobile application><mobile device application><novel><parent><parent award><parent grant><parent project><patient centered><patient oriented><patient oriented outcomes><physical symptom><pilot trial><primary outcome><programs><prototype><psychologic><psychological><psychological distress><psychological symptom><pulmonary function><qualitative reasoning><quality of life for caregivers><radiation treatment><randomized control trial><sleep disruption><sleep dysregulation><social health determinants><social role><treatment with radiation><trial design><uptake><usability><user centered design><vulnerable group><vulnerable individual><vulnerable people>
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Carissa A Low

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 20/100
Solid budget
Active award
$358,674
FY 2025

Project Title

A mobile sensing system to monitor symptoms during chemotherapy

Grant Number:

5R37CA242545-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2019

End Date:

6/30/2026

Project Abstract

Abstract The aims of the parent R37 grant were (1) to develop and refine a mobile sensing system that applies machine learning to smartphone and wearable sensor data to passively detect symptom burden during chemotherapy and (2) to evaluate the feasibility and acceptability of using this system in a...

Research Terms

<Address><Award><Behavior><Behavioral><Cancer Treatment><Cardiac Chronotropism><Cell Phone><Cellular Phone><Cellular Telephone><Chemotherapy Protocol><Chemotherapy Regimen><Chemotherapy-Oncologic Procedure><Classification><Clinic><Clinic Visits><Clinical><Combination Chemotherapy Regimen><Communication><Computer Models><Computerized Models><Coupled><Data><Detection><Devices><Early Diagnosis><Enrollment><Fostering><Goals><Grant><Health Status><Heart Rate><Impairment><Infrastructure><Instruction><Intervention><Level of Health><Life><Light><Location><Machine Learning><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Medical><Mobile Phones><Modeling><Monitor><Noise><Notification><Oncology><Oncology Cancer><Outcome><Parents><Participant><Patient Monitoring><Patients><Pattern><Phase><Phone><Photoradiation><Physical activity><Population><Prospective, cohort study><Provider><QOL><QOL improvement><Quality of life><Quimioterapia><Recommendation><Reporting><Research><Running><Secure><Sedentary behavior><Sedentary life-style><Severities><Sleep><Sleep disturbances><Social Support System><Support System><Symptom Burden><Symptoms><System><Systematics><Telephone><Time><Toxic effect><Toxicities><Trust><Work><aberrant sleep><acceptability and feasibility><anti-cancer therapy><arm><body sensor><body worn sensor><cancer care><cancer chemotherapy><cancer therapy><cancer-directed therapy><care delivery><care outcomes><chemotherapy><clinical significance><clinically actionable><clinically significant><common treatment><computational modeling><computational models><computer based models><computer based prediction><computerized modeling><data captured from wearables><data collected from wearables><data collected using wearables><data gathered from wearable><data gathered through wearables><data gathered via wearable><design><designing><digital health><disrupted sleep><disturbed sleep><early detection><enroll><falls><feasibility testing><health care outcomes><health level><iPhone><impaired sleep><improved><improvements in QOL><improvements in quality of life><irregular sleep><machine based learning><machine learning based method><machine learning based model><machine learning method><machine learning methodologies><machine learning model><manage symptom><mobile computing><mobile platform><mobile sensing><mobile sensor><mobile technology><novel><online app><parent><parent grant><patient centered><patient oriented><patient-clinician communication><patient-doctor communication><patient-provider communication><patient-provider contact><portable sensor><predictive modeling><prospective><public health relevance><quality of life improvement><remote monitoring><sedentary lifestyle><sensing data><sensor><sensor data><sleep disruption><sleep dysregulation><sleep/wake disruption><sleep/wake disturbance><smart phone><smartphone><symptom management><wearable><wearable biosensor><wearable data><wearable device><wearable device data><wearable electronics><wearable sensor><wearable sensor data><wearable sensor technology><wearable system><wearable technology><wearable tool><wearables><web app><web application><web based app><web based application>
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Rama Rao Amara

EMORY UNIVERSITY, ATLANTA, GA

Exploratory lead · 18/100
Above-average budget
$807,098
FY 2023

Project Title

Targeting PD-1 Pathway for Functional Cure of AIDS

Grant Number:

5R37AI112787-10

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2019

End Date:

1/31/2024

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

The overall goal of this proposal is to evaluate the safety and therapeutic potential of in vivo blockade of the PD-1 (Programmed death-1) co-inhibitory pathway to achieve a functional cure (long-term control in the absence of antiretroviral therapy) for HIV/AIDS using the SIV/macaque model. Dysfu...

Research Terms

<AIDS><AIDS Virus><AIDS/HIV><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immuno-Deficiency Syndrome><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Acquired Immunologic Deficiency Syndrome><Address><Adjuvant><Agonist><Animals><Antibodies><Area><Award><BLR1><BLR1 gene><Binding><CD154><CD40L><CD40LG><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><CXCR-5><CXCR5><Cell Body><Cell Function><Cell Process><Cell physiology><Cells><Cellular Function><Cellular Physiology><Cellular Process><Co-culture><Cocultivation><Coculture><Coculture Techniques><Communication><Contracting Opportunities><Contracts><DNA/MVA vaccine><Data><Dose><Funding><Generations><Genetic Alteration><Genetic Change><Genetic defect><Goals><Grant><HIV><HIV/AIDS><Home><Homing><Human><Human Immunodeficiency Viruses><Immune mediated therapy><Immune system><Immunity><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologically Directed Therapy><Immunologics><Immunotherapy><In Vitro><Infection><Instruction><Interruption><LAV-HTLV-III><LYT3><Lymphadenopathy-Associated Virus><M mulatta><M. mulatta><MDR15><Macaca><Macaca mulatta><Macaque><Manuscripts><Modeling><Modern Man><Molecular Interaction><Mutation><PD 1><PD-1><PD-1 antibody><PD1><PD1 antibody><Pathway interactions><Principal Investigator><Progress Reports><Research><Rhesus Macaque><Rhesus Monkey><SIV><Safety><Simian Immunodeficiency Viruses><Subcellular Process><System><T-Cells><T-Lymphocyte><T8 Cells><T8 Lymphocytes><TLR7><TLR7 gene><TNFSF5><TNFSF5 gene><TRAP Gene><Therapeutic><Time><Toll-Like Receptor 7><VAC-TX><Vaccination><Vaccine Therapy><Viral><Viral Activity><Viral Function><Viral Physiology><Viral reservoir><Virus><Virus reservoir><Virus-HIV><Work><anti-PD-1 Ab><anti-PD-1 antibodies><anti-PD-1 monoclonal antibodies><anti-PD1 Ab><anti-PD1 antibodies><anti-PD1 monoclonal antibodies><anti-programmed cell death protein 1 antibodies><anti-programmed death-1 antibody><anti-retroviral therapy><anti-retroviral treatment><antiretroviral therapy><antiretroviral treatment><density><efficacy testing><experiment><experimental research><experimental study><experiments><genome mutation><homes><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><improved><in vivo><manufacture><novel><pathway><programmed cell death 1><programmed cell death protein 1><programmed death 1><programs><sle2><synergism><systemic lupus erythematosus susceptibility 2><therapeutic vaccination><thymus derived lymphocyte><viral rebound><virus rebound>
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Summer S Han

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 18/100
Above-average budget
$621,799
FY 2024

Project Title

Evaluation of genetic, clinical and environmental risk factors to establish effective screening strategies for second primary lung cancer

Grant Number:

5R37CA226081-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2018

End Date:

4/30/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Lung cancer (LC) is the leading cause of cancer deaths in the U.S. The widespread adoption of low dose computed tomography (LDCT) screening enables the early detection of LC and is expected to increase the number of long-term LC survivors. While recent studies show that LC survivors have a high risk...

Research Terms

<Active Follow-up><Address><Adoption><Assessment instrument><Assessment tool><Behavioral><CT screening><Calibration><Cancer Cause><Cancer Etiology><Cancer Patient><Cancer Survivor><Cessation of life><Characteristics><Clinical><Cohort Studies><Colon or Rectum><Colorectal><Concurrent Studies><Consensus><Consensus Development><Cost Savings><Data><Death><Diagnosis><Drug Therapy><Environmental Factor><Environmental Risk Factor><Evaluation><Exclusion><Genetic><Genetic Risk><Goals><Health Care Systems><Healthcare Systems><Individual><Life><Long-Term Survivors><Lung><Lung Respiratory System><Malignant Tumor of the Lung><Malignant neoplasm of lung><Measures><Medical History><Meta-Analysis><Modeling><Morbidity><Morbidity - disease rate><Ovarian><PLCO study><PLCO trial><Parents><Patients><Performance><Personal Medical History><Personal Medical History Epidemiology><Pharmacotherapy><Population><Predictive Cancer Model><Preventative measure><Preventive measure><Prospective, cohort study><Prostate><Prostate Gland><Prostate, Lung, Colo-rectal and Ovarian (PLCO) Cancer Screening Trial><Prostate, Lung, Colo-rectal and Ovarian Cancer (PLCO) screening trial><Prostate, Lung, Colo-rectal, and Ovarian (PLCO)><Prostate, Lung, Colo-rectal, and Ovarian Cancer Screening Trial><Prostate, Lung, Colorectal and Ovarian (PLCO) Cancer Screening Trial><Prostate, Lung, Colorectal and Ovarian Cancer (PLCO) screening trial><Prostate, Lung, Colorectal, and Ovarian (PLCO)><Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial><Prostate, Lung, Ovarian (PLCO)><Prostatic Gland><Public Health><Pulmonary Cancer><Pulmonary malignant Neoplasm><Risk><Risk Assessment><Risk Factors><Role><Sample Size><Smoker><Smoking><Smoking History><Survivors><Time><Translating><Uncertainty><Update><Validation><active followup><biobank><biorepository><cancer risk><cease smoking><clinical risk><cohort><colorectum><computed tomography screening><computer based prediction><doubt><drug treatment><environmental risk><follow up><follow-up><followed up><followup><hazard><high risk><improved><longterm survivors><low dose computed tomography><low dose computerized tomography><low-dose CT><lung cancer><lung cancer early detection><lung cancer screening><model-based simulation><models and simulation><mortality><multi-ethnic><multiethnic><pack/year><parent><parent grant><predictive modeling><programs><prostate, lung, colorectal and ovarian cancer screening cohort><prostate, lung, colorectal, and ovarian cancer screening><pulmonary><quit smoking><recommended screening><risk prediction algorithm><risk prediction model><screening><screening guidelines><screening recommendations><screenings><smoking cessation><social role><standard of care><stop smoking><tool><tumor><validations>
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Allison Payne

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 18/100
Above-average budget
$506,060
FY 2024

Project Title

Validation and translation of a non-invasive, MR-guided breast cancer therapy

Grant Number:

5R37CA224141-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

The treatment of early stage, localized breast cancer has evolved over several decades from highly invasive techniques to minimally invasive, breast-conserving therapies. Our breast-specific magnetic resonance-guided focused ultrasound system non-invasively delivers focused energy deep inside the bo...

Research Terms

<Ablation><Acceleration><Algorithms><Alprostadil><Applications Grants><Body Tissues><Breast><Breast Cancer><Breast Cancer Patient><Breast Cancer Treatment><Breast Cancer therapy><Breast Diseases><Breast Disorder><Breast Tumor Patient><Breast conservation><Caverject><Cicatrix><Clinical><Clinical Treatment><Clinical Trials><Collaborations><Computer software><Data><Early treatment><Early-Stage Clinical Trials><Ensure><Environment><Fats><Fatty acid glycerol esters><Fiber Optics><Focused Ultrasound><Functional impairment><Gadolinium><Gd element><Grant Proposals><Histology><Histopathology><Hybrids><Image><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Industrialization><Industry><Infection><Institution><Intervention><Intervention Strategies><Investigators><Lipo-PGE1><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance><Magnetic Resonance Imaging><Malignant Breast Neoplasm><Measurement><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methodology><Methods><Modeling><Monitor><Morbidity><Morbidity - disease rate><Muse><NMR Imaging><NMR Tomography><Nuclear Magnetic Resonance Imaging><Operative Procedures><Operative Surgical Procedures><PGE1><PGE1alpha><Patients><Phase><Phase 1 Clinical Trials><Phase I Clinical Trials><Planning Methodology><Planning Technic><Planning Techniques><Procedures><Process><Prostaglandin E1><Prostaglandin E1alpha><Protocol><Protocols documentation><Recovery><Research Personnel><Research Resources><Researchers><Resected><Resources><Safety><Scanning><Scars><Scientist><Site><Software><Surgical><Surgical Interventions><Surgical Procedure><System><Techniques><Technology><Temperature><Thermometry><Time><Tissues><Translating><Translations><Universities><Utah><Validation><Work><Zeugmatography><aqueous><clinic ready><clinical ready><clinical translation><clinically translatable><cost><early therapy><experience><high resolution imaging><image guidance><image guided><image guided therapy><imaging><improved><in vivo><in vivo Model><industrial partnership><industry partner><industry partnership><innovate><innovation><innovative><interventional strategy><malignant breast tumor><mammary disorder><minimally invasive><necrotic tissue><non-invasive system><noninvasive system><novel><parent grant><phase I protocol><pre-clinical><pre-clinical evaluation><preclinical><preclinical evaluation><prototype><psychological distress><real time monitoring><realtime monitoring><safety assessment><simulation><surgery><tissue necrosis><tool><translation><treatment planning><trial regimen><trial treatment><tumor><ultrasound><validations>
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Terrell Alexander Hicks

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

Exploratory lead · 18/100
Training-friendly
$18,622
FY 2022

Project Title

Genetics of Cannabis use and Trauma-related phenotypes

Grant Number:

5F31DA048559-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

3/16/2020

End Date:

6/30/2022

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The college years encompass a period of increased risk for substance use, and in particular, cannabis use (CU), as well as a time of increased risk for trauma exposure and resulting posttraumatic stress disorder (PTSD). Given the high comorbidity between substance use disorders such...

Research Terms

<Age-Years><Attention><Award><Behavioral><Biological><Cannabis><Causality><Chemical Dependence><Clinical><Collaborations><Complex><Data><Development><Dropout><Drug Addiction><Drug Dependence><Drug Dependency><Drug usage><Early Intervention><Educational workshop><Environmental Factor><Environmental Risk Factor><Ethics><Etiology><Exercise><Exposure to><Foundations><Frequencies><Future><GWA study><GWAS><Genetic><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Risk><Genetic Susceptibility><Genetic analyses><Goals><Heritability><History><Individual><Inherited Predisposition><Inherited Susceptibility><Interdisciplinary Research><Interdisciplinary Study><International><Intervention><Intervention Strategies><Knowledge><Length of Life><Longevity><Longitudinal Studies><Mental Health><Mental Hygiene><Mentorship><Mission><Modeling><Molecular><Molecular Analysis><Molecular Genetics><Multidisciplinary Collaboration><Multidisciplinary Research><NIAAA><NIDA><NRSA><National Institute of Drug Abuse><National Institute on Alcohol Abuse and Alcoholism><National Institute on Drug Abuse><National Research Service Awards><Outcome><PTSD><Pattern><Phenotype><Population><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Posttraumatic Stress Disorders><Predisposition><Prevalence><Preventative intervention><Psychological Health><Recording of previous events><Research><Research Training><Risk><Risk Factors><Sampling><Science><Self Medication><Solid><Statistical Methods><Strategic Planning><Substance Use Disorder><Susceptibility><THC co-use><THC use><Techniques><Testing><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Time><Training><Trauma><Twin Multiple Birth><Twins><Universities><Workshop><adult youth><base><biologic><cannabis use><cannabis use disorder><career><causation><clinical relevance><clinical significance><clinically relevant><clinically significant><co-morbid><co-morbidity><college><college student><collegiate><comorbidity><developmental><disease causation><drug use><environmental risk><ethical><experience><exposure to trauma><genetic analysis><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><genome scale><genome wide association><genome wide association scan><genome wide association studies><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association studies><genomewide association study><high risk><innovate><innovation><innovative><intervention for prevention><interventional strategy><life span><lifespan><long-term study><longitudinal analysis><longitudinal outcome studies><longterm study><marijuana use><marijuana use disorder><phenotypic data><physical conditioning><physical health><polygenic risk score><post-trauma stress disorder><posttrauma stress disorder><prevention intervention><preventional intervention strategy><preventive intervention><prospective><psychiatric genomics><skill acquisition><skill development><social><statistics><substance use><substance using><suicidal risk><suicide risk><trait><trauma exposure><traumatic event><traumatic neurosis><university student><whole genome association analysis><whole genome association studies><whole genome association study><young adult><young adulthood>
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Shannon Cusack

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

Exploratory lead · 18/100
Training-friendly
$16,160
FY 2021

Project Title

The Buffering Effects of Resilience on Alcohol Use: A Phenotypic and Genotypic Investigation

Grant Number:

5F31AA027703-03

Activity Code:

F31

Mechanism:

Training, Individual

Agency:

NIH

Start Date:

5/10/2019

End Date:

8/27/2021

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY The college years encompass a time of vulnerability for problematic alcohol use/alcohol use disorder (AUD) and trauma exposure, which is a transdiagnostic risk factor for AUD, posttraumatic stress disorder (PTSD), and comorbid AUD-PTSD. However, not all who experience a traumatic ev...

Research Terms

<Age-Years><Alcohol Chemical Class><Alcohol Drinking><Alcohol Phenotype><Alcohol abuse><Alcohol consumption><Alcohols><Award><Behavioral><Biological Markers><Buffers><Causality><Child Rearing><Clinical><Collaborations><Complex><Consumption><Data><Development><Disease><Disorder><Dropout><EtOH abuse><EtOH drinking><EtOH use><Etiology><Foundations><GWA study><GWAS><Genetic><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Risk><Genetic Susceptibility><Genetic Technics><Genetic Techniques><Genotype><Goals><Heritability><Heterogeneity><Individual><Inherited Predisposition><Inherited Susceptibility><Interdisciplinary Research><Interdisciplinary Study><Intervention><Intervention Strategies><Investigation><Investigators><Literature><Long-term cohort study><Longitudinal Studies><Longitudinal cohort study><Longterm cohort study><Measures><Mentorship><Methods><Mission><Modeling><Molecular><Molecular Analysis><Molecular Genetics><Multidisciplinary Collaboration><Multidisciplinary Research><NIAAA><National Institute on Alcohol Abuse and Alcoholism><Nature><Outcome><PTSD><Parenting><Parenting behavior><Personal Satisfaction><Phenotype><Play><Population><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Posttraumatic Stress Disorders><Prevention><Probabilistic Models><Probability Models><Psychosocial Factor><Research><Research Personnel><Research Training><Researchers><Risk><Risk Factors><Role><Sampling><Science><Solid><Statistical Methods><Statistical Models><Testing><Time><Training><Trauma><Universities><Variant><Variation><adverse consequence><adverse outcome><aged><alcohol co-abuse><alcohol co-morbidity><alcohol comorbidity><alcohol ingestion><alcohol intake><alcohol problem><alcohol product use><alcohol related consequences><alcohol risk><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><alcoholic phenotype><at-risk drinking><binge alcohol consumption><binge drinking><bio-markers><biologic marker><biomarker><causation><childrearing><clinical relevance><clinically relevant><co-morbid><co-morbidity><college><college student><collegiate><comorbidity><design><designing><developmental><deviancy><deviant><disease causation><drinking behavior><episodic drinking><ethanol abuse><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><ethanol use disorder><experience><exposure to trauma><genetic architecture><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><genome scale><genome wide analysis><genome wide association><genome wide association scan><genome wide association studies><genome wide association study><genome wide studies><genome-wide><genome-wide analysis><genome-wide identification><genomewide><genomewide association scan><genomewide association studies><genomewide association study><hazardous alcohol use><high risk drinking><improved><insight><interventional strategy><long-term study><longitudinal analysis><longitudinal outcome studies><longterm study><novel><peer><phenotypic data><polygenic risk score><post-trauma><post-trauma stress><post-trauma stress disorder><post-traumatic stress><posttrauma><posttrauma stress><posttrauma stress disorder><posttraumatic stress><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><protective factors><psychosocial variables><resilience><risky drinking><skill acquisition><skill development><social role><statistical linear mixed models><statistical linear models><stressor><trait><trauma exposure><traumatic event><traumatic neurosis><traumatic stress><university student><well-being><wellbeing><whole genome association analysis><whole genome association studies><whole genome association study>
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Emily E Scott

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 10/100
Solid budget
$382,037
FY 2024

Project Title

Structural Basis of Cytochrome P450 Activity

Grant Number:

5R37GM076343-20

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2006

End Date:

2/28/2025

Project Abstract

A subset of cytochrome P450 enzymes perform the first and rate-limiting step in the clearance of foreign small molecule drugs and toxins from the human body, while others play key roles in endogenous pathways. Of necessity the former evolved the flexibility to bind and oxidize a broad range of small...

Research Terms

<Active Sites><Adopted><Area><Artificial Genes><Bile Acids><Binding><CP34><CPT7><CYP17><CYP17A1><CYP17A1 gene><CYP2S1><CYP2S1 gene><CYP3><CYP3A><CYP3A4><CYP3A4 gene><Chemicals><Collaborations><Complex><Cryo-electron Microscopy><Cryoelectron Microscopy><Crystallization><Cytochrome P-450><Cytochrome P-450 Enzyme System><Cytochrome P450><Cytochrome P450 3A4><Cytochrome P450 Family Gene><Cytochrome P450, Family 2, Subfamily S, Polypeptide 1><Cytochrome P450, Subfamily IIIA, Polypeptide 4><Cytochrome P450, Subfamily IIS, Polypeptide 1><Cytochrome P450PCN1><Cytochromes><Data><Data Set><Dehydrogenases><Disease><Disorder><Drugs><Eicosanoids><Electron Cryomicroscopy><Electrons><Engineering><Enzyme Gene><Enzymes><FAMILY III P450><Face><Fatty Acids><Glucocorticoid-Inducible P450><Goals><Grant><Hand><Human><Human Figure><Human body><Individual><Label><Ligand Binding><Ligands><Medication><Membrane><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Modern Man><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Negative Beta Particle><Negatrons><Nifedipine Oxidase><Oxidation-Reduction><Oxidoreductase><Oxidoreductase Gene><P450><P450C17><P450C3><P450PCN1><Pathway interactions><Pharmaceutical Preparations><Play><Proteins><Qualifying><Redox><Reductases><Research><Resolution><Roentgen Rays><S17AH><Single Crystal Diffraction><Steroid-Inducible P450- III><Structure><Substrate Specificity><Surface><Surface Proteins><Synthetic Genes><System><Techniques><Toxin><Visualization><Vitamins><X Ray Crystallographies><X-Radiation><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray Radiation><X-Ray/Neutron Crystallography><X-ray><Xray><Xray Crystallography><alpha helix><conformation><conformational><conformational state><conformationally><conformations><cryo-EM><cryoEM><cryogenic electron microscopy><drug/agent><faces><facial><flexibility><flexible><hands><human disease><inhibitor><interest><membrane structure><oxidation reduction reaction><pathway><prevent><preventing><resolutions><scaffold><scaffolding><small molecule><structural genomics><success><tool><toxin metabolism><α-helix>
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Ovijit Chaudhuri

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 10/100
Solid budget
$329,164
FY 2024

Project Title

Role of extracellular matrix malleability in mediating breast cancer cell invasion and migration

Grant Number:

5R37CA214136-07

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2018

End Date:

6/30/2025

Project Abstract

Ductal carcinoma is the most common form of breast cancer and progresses to invasive ductal carcinoma (IDC) when the carcinoma invades through the basement membrane (BM) into the stromal tissue. Invasion is a key step in ductal carcinoma progression that is associated with an increased likelihood fo...

Research Terms

<3D cell culture><3D culture><Actins><Actomyosin><Award><Basement membrane><Benign><Biocompatible Materials><Biomaterials><Biophysical Process><Bleb><Blister><Body Tissues><Breast Cancer><Breast Cancer Cell><Bulla><Bullous Lesion><Carcinoma><Carcinoma Cell><Cell Body><Cell Cycle Progression><Cell Locomotion><Cell Migration><Cell Movement><Cell-Extracellular Matrix><Cells><Cellular Migration><Cellular Motility><Characteristics><Clinical Trials><Collagen><Collagen Type I><DCIS><Disease><Disorder><Ductal Breast Carcinoma In Situ><Ductal Carcinoma><Ductal Carcinoma In Situ><ECM><Elasticity><Endothelium><Epithelial cancer><Epithelium><Esteroproteases><Exhibits><Extracellular Matrix><Extravasation><Failure><Filopodia><Goals><Human><Individual><Integrin Binding><Integrins><Integrins Extracellular Matrix><Intervention><Intervention Strategies><Intraductal Carcinoma><Intraductal Carcinoma of the Breast><Invaded><Knowledge><Leakage><Lesion><Ligands><MMP Inhibitor><Malignant><Malignant - descriptor><Malignant Breast Neoplasm><Malignant Cell><Malignant Epithelial Cell><Malignant Epithelial Neoplasms><Malignant Epithelial Tumors><Matrix Metalloproteinase Inhibitor><Measures><Mechanics><Mediating><Mesenchymal><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Mission><Mitotic><Modeling><Modern Man><Molecular><Molecular Target><Morphology><Motility><NIH><Nanoporous><National Institutes of Health><Nature><Neoplasm Metastasis><Non-Infiltrating Ductal Breast Adenocarcinoma><Non-Infiltrating Ductal Carcinoma of the Breast><Non-Infiltrating Intraductal Adenocarcinoma><Non-Infiltrating Intraductal Breast Adenocarcinoma><Non-Invasive Ductal Breast Adenocarcinoma><Non-Invasive Ductal Carcinoma of the Breast><Non-Invasive Intraductal Breast Adenocarcinoma><Noninfiltrating Intraductal Carcinoma><Peptidases><Peptide Hydrolases><Phase><Physiologic><Physiological><Polymers><Process><Proliferating><Protease Gene><Proteases><Proteinases><Proteolytic Enzymes><Public Health><Research><Resistance><Role><Secondary Neoplasm><Secondary Tumor><Spillage><Testing><Tissues><Type 1 Collagen><United States National Institutes of Health><Vesication><Viscosity><Work><biological material><biophysical mechanism><breast cancer progression><breast epithelium><breast lesion><breast tumor cell><cancer cell><cancer metastasis><cancer progression><cancer type><cell motility><cell type><crosslink><density><disability><duct carcinoma><epigenome><epithelial carcinoma><infiltrating duct carcinoma><infiltrating ductal adenocarcinoma><infiltrating ductal carcinoma><innovate><innovation><innovative><integrin bound><interventional strategy><invasive ductal adenocarcinoma><invasive ductal carcinoma><malignant breast tumor><malignant phenotype><mammary epithelium><mechanic><mechanical><mechanical properties><migration><mortality><neoplasm progression><neoplastic progression><new diagnostics><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation diagnostics><novel><novel diagnostics><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pharmacologic><polymer><polymeric><polymerization><prevent><preventing><resistant><social role><three dimensional cell culture><tumor cell metastasis><tumor progression><viscoelasticity>
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CHARLES H. LANG

PENNSYLVANIA STATE UNIV HERSHEY MED CTR, HERSHEY, PA

Exploratory lead · 10/100
Solid budget
$327,938
FY 2021

Project Title

Regulation of Nutrient Sensing and Muscle Wasting by Alcohol

Grant Number:

5R37AA011290-26

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/5/2017

End Date:

7/31/2023

Project Abstract

Muscle wasting is a hallmark of sustained alcohol abuse and the associated weakness represents the most common form of skeletal muscle myopathy. Over the past 4 years we have used genetic, biochemical and pharmacological approaches, both in vivo and in vitro, to generate definitive evidence pertaini...

Research Terms

<21+ years old><Acute><Address><Adult><Adult Human><Alcohol Chemical Class><Alcohol Intoxication><Alcohol abuse><Alcoholic Intoxication><Alcohols><Amino Acids><Area><Autophagocytosis><Binding><Biochemical><Birds of Prey><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chronic><Complex><Data><Degradation Pathway><Degradative Pathway><Development><Doxycycline><Drunkenness><Electroporation><Endocrine Gland Secretion><Environment><EtOH abuse><EtOH intoxication><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Face><Female><Funding><Future><GTP Phosphohydrolases><GTPases><Genetic><Goals><Growth Agents><Growth Factor><Growth Substances><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Health><Hormones><Impairment><In Vitro><Instruction><Intoxication><Intracellular Communication and Signaling><KO mice><Kinases><Knock-out Mice><Knockout Mice><Knowledge><Laboratories><Leucine><Mechanistic Target of Rapamycin><Mediating><Medical Rehabilitation><Membrane><Methods><Mice><Mice Mammals><Modeling><Molecular><Molecular Interaction><Murine><Mus><Muscle><Muscle Atrophy><Muscle Cells><Muscle Disease><Muscle Disorders><Muscle Fibers><Muscle Proteins><Muscle Tissue><Muscular Atrophy><Muscular Diseases><Myocytes><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Myotubes><Null Mouse><Nutrient><Nutritional><Outcome><PP2A><PP2A Subunit B Prime><Pathology><Pathway interactions><Pharmacology><Phase><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Phosphotyrosyl Phosphatase Activator><Physiologic><Physiological><Postdoc><Postdoctoral Fellow><Protein Biosynthesis><Protein Phosphatase 2A Regulatory Subunit B Prime><Protein Phosphatase 2A Regulatory Subunit PR53><Protein Phosphorylation><Proteins><Proteins Growth Factors><Proteomics><Public Health><Publications><Publishing><RAFT1><Raptors><Reagent><Regulation><Rehabilitation><Rehabilitation therapy><Research><Research Associate><Resistance><Rhabdomyocyte><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Scientific Publication><Seminal><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Societies><System><Therapeutic Hormone><Time><Training><Transphosphorylases><Vibramycin><Voluntary Muscle><Work><access to alcohol><adulthood><alcohol access><alcohol accessibility><alcohol availability><alcohol co-abuse><alcohol effect><alcohol problem><alcohol related research><alcohol research><alcohol use disorder><alcoholic myopathy><alpha-6-Deoxyoxytetracycline><aminoacid><autophagy><base><binge alcohol consumption><binge drinking><biological signal transduction><chronic EtOH drinking><chronic alcohol consumption><chronic alcohol drinking><chronic alcohol ingestion><chronic alcohol use><chronic ethanol consumption><chronic ethanol drinking><chronic ethanol ingestion><clinical significance><clinically significant><detection of nutrient><developmental><economic cost><electroporative delivery><episodic drinking><ethanol abuse><ethanol accessibility><ethanol availability><ethanol effect><ethanol intoxication><ethanol research><ethanol use disorder><experiment><experimental research><experimental study><faces><facial><gene electrotransfer><guanosinetriphosphatase><hazardous alcohol use><in vivo><innovate><innovation><innovative><insight><knock-down><knockdown><mTOR><male><mammalian target of rapamycin><membrane structure><mortality><mouse model><murine model><muscle breakdown><muscle degradation><muscle deterioration><muscle loss><muscle wasting><muscular><muscular disorder><novel><nutrient sensing><nutritious><overexpress><overexpression><pathway><perception of nutrients><post-doc><post-doctoral><premature><prematurity><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><protein complex><protein synthesis><recruit><rehab therapy><rehabilitative><rehabilitative therapy><resistant><response><shRNA><short hairpin RNA><small hairpin RNA><therapeutic target><tool><trafficking>
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Roger B Fillingim

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 10/100
Solid budget
$312,252
FY 2023

Project Title

Elucidating Factors Contributing to Disparities in Neurobiological Vulnerabilities and Alzheimers Disease and Related Dementias Risk

Grant Number:

3R37AG033906-20S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2009

End Date:

2/28/2025

Project Abstract

Project Summary/Abstract Underrepresented ethnic/race groups have a disproportionately higher incidence of Alzheimer’s disease and related dementias (ADRD) with numbers expected to double by 2060. Numerous health conditions increase risk of ADRD including chronic pain. Although an extensive body of ...

Research Terms

<21+ years old><AD related dementia><ADRD><Address><Adult><Adult Human><Affect><Age><Alabama><Alzheimer risk factor><Alzheimer's and related dementias><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimer's disease risk><Attention><Behavior><Brain><Brain Nervous System><Breathing><Clinical><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Combined Modality Therapy><Communication><Complex><Data><Data Collection><Degenerative Arthritis><Degenerative polyarthritis><Differences between sexes><Differs between sexes><Disparities><Disparity><Disturbance in cognition><Dose><Emotions><Encephalon><Equilibrium><Ethnic Origin><Ethnicity><Florida><Functional Imaging><Goals><Health><History><Impaired cognition><Incidence><Individual><Individual Differences><Intervention><Intervention Strategies><Intervention Studies><Investigation><Leanness><Link><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Modeling><Multimodal Therapy><Multimodal Treatment><NMR Imaging><NMR Tomography><Neurobiology><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Nuclear Magnetic Resonance Imaging><Osteoarthritis><Osteoarthrosis><Pain><Painful><Participant><Patients><Pattern><Physiologic><Physiologic Imaging><Physiological><Prevalence><Productivity><Psychopathology><Psychosocial Stress><Publishing><Racial Group><Randomized><Recording of previous events><Recovery><Reporting><Research><Research Resources><Resources><Respiratory Aspiration><Respiratory Inspiration><Risk><Science><Severities><Sex Differences><Sexual differences><Social Environment><Stress><Structure><Temporal Lobe><Thinness><Training><Universities><Zeugmatography><abnormal psychology><adulthood><aged brain><ages><aging brain><alzheimer risk><balance><balance function><chronic pain><clinical care><clinical relevance><clinically relevant><cognitive dysfunction><cognitive loss><combination therapy><combined modality treatment><combined treatment><customized therapy><customized treatment><degenerative joint disease><dementia risk><experience><gray matter><histories><hypertrophic arthritis><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><inspiration><intervention research><interventional research><interventional strategy><interventional study><interventions research><knee pain><mindfulness><multi-modal therapy><multi-modal treatment><neurobiological><osteoarthritic><pain relief><patient specific therapies><patient specific treatment><physiological imaging><poor health outcome><post intervention><psychosocial><racial population><racial subgroup><randomisation><randomization><randomly assigned><recruit><reduced health outcome><relieve pain><response><response to therapy><response to treatment><risk factor for dementia><risk for dementia><sex-dependent differences><sex-related differences><sex-specific differences><social climate><social context><socioenvironment><socioenvironmental><socioenvironmental factor><substantia grisea><tailored medical treatment><tailored therapy><tailored treatment><temporal cortex><therapeutic response><therapy response><trait><transcranial direct current stimulation><treatment planning><treatment response><unique treatment><worse health outcome>
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Karuna Ganesh

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Exploratory lead · 10/100
Solid budget
$254,999
FY 2024

Project Title

Functional modeling of race-specific features underlying phenotypic reprogramming in metastatic stem cells from colorectal cancer patients

Grant Number:

3R37CA266185-03S2

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2026

Project Abstract

PROJECT SUMMARY (unchanged from Parent R37) Metastasis causes >90% of cancer death. The persistence and lethality of metastasis is driven by cells capable of self-renewal, slow cell-cycling, tumor re-initiation, and therapy resistance, termed metastasis stem cells (MetSCs). Development of effective ...

Research Terms

<3' Untranslated Regions><3'UTR><Active Follow-up><Adherens Junction><Adhering Junction><Adhesive Junction><Advanced Cancer><Advanced Malignant Neoplasm><Aggression><Aggressive behavior><Anchoring Junction><Antioncogene Protein p53><Automobile Driving><Autoregulation><BFU-E><BFU-E - Burst-form unit eryth><BFU-E - Burst-forming unit erythroid><Binding><Biologic Factor><Biologic Models><Biological><Biological Factors><Biological Models><Biology><Black><Black Populations><Black group><Black individual><Black people><Black race><Blacks><Body Tissues><C-K-RAS><CALL protein><Cadherin-1><CamL1 Gene Product><Cancer Genes><Cancer Model><Cancer-Promoting Gene><CancerModel><Cancers><Caring><Cell Body><Cell Cycle><Cell Division Cycle><Cell Surface Glycoprotein L1><Cells><Cellular Tumor Antigen P53><Cessation of life><Chromatin><Clinical><Clinical Data><Colitis><Colon><Colorectal Cancer><Communities><Data><Death><Development><Disparities><Disparity><E-Cadherin><EGF-Response Factor 2><ERF2><Elements><Engineering><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelial Calcium-Dependent Adhesion Protein><Epithelial Cells><Epithelial-Cadherin><Epithelium><Erythroid Burst-Forming Units><F11 Glycoprotein><Family><Gene Transcription><Genes><Genetic><Genetic Alteration><Genetic Change><Genetic Transcription><Genetic defect><Genomics><Genotype><Germ Lines><Goals><HG38><Heterograft><Heterologous Transplantation><Homeostasis><Impairment><Incidence><Intestinal><Intestinal Neoplasia><Intestinal Neoplasms><Intestinal Tumor><Intestines><Intestines Neoplasms><Invaded><K-RAS2A><K-RAS2B><K-Ras><K-Ras 2A><K-Ras-2 Oncogene><KRAS><KRAS2><KRAS2 gene><Ki-RAS><L1 Cell Adhesion Molecule><L1CAM><LGR5><LGR5 gene><Lymphatic cell><Lymphocyte><Lymphocytic><Maintenance><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mediating><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Methods><Mice><Mice Mammals><Model System><Modeling><Molecular><Molecular Interaction><Mouse Homolog of TIS11D><Murine><Mus><Muscle><Muscle Tissue><Mutation><NGF-Inducible Glycoprotein><NILE Glycoprotein><NILE Protein><Natural regeneration><Neoplasm Metastasis><Nerve Cells><Nerve Growth Factor-Inducible Large External Glycoprotein><Nerve Unit><Neural Adhesion Molecule L1><Neural Cell><Neural Cell Adhesion Molecule L1><Neurocyte><Neurons><Non-Hispanic><Nonhispanic><Normal Tissue><Normal tissue morphology><Not Hispanic or Latino><Obesity><Oncogene K-Ras><Oncogenes><Oncoprotein p53><Organoids><Outcome><P53><Parents><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phenotype><Phosphoprotein P53><Phosphoprotein pp53><Physiologic><Physiological><Physiological Homeostasis><Pre-Clinical Model><Preclinical Models><Prevalence><Primary Neoplasm><Primary Tumor><Progenitor Cells><Proliferating><Protein TP53><RASK2><RNA Expression><RNA-Binding Proteins><Race><Races><Regeneration><Regulation><Research><Resistance><Risk Factors><Role><Sampling><Secondary Neoplasm><Secondary Tumor><Smoking><Stem Cell like><Stress><Structure><TIS11D><TP53><TP53 gene><TRP53><Testing><Time><Tissues><Transcription><Transforming Genes><Tumor Protein p53><Tumor Protein p53 Gene><Tumor Tissue><Tumor-Derived><Uvomorulin><Work><Wound Repair><Xenograft><Xenograft procedure><Xenotransplantation><ZFP36-Like 2><ZFP36L2><ZFP36L2 gene><Zinc Finger Protein 36-Like 2><access to health care><access to healthcare><accessibility of health care><accessibility to health care><accessibility to healthcare><active followup><adiposity><biobank><biologic><biorepository><black patient><bowel><cancer cell><cancer genetics><cancer genomics><cancer metastasis><cancer progenitor><cancer progenitor cells><cancer progression><cancer stem cell><catalyst><chemotherapy><colon cancer patients><colorectal cancer patients><colorectal cancer progression><colorectal cancer therapy><colorectal cancer treatment><corpulence><derepression><developmental><disparities in race><disparity due to race><disparity in ethnic><driver lesion><driver mutation><driving><drug detection><drug testing><epigenetically><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><ethnic based disparity><ethnic disadvantage><ethnic disparity><ethnic inequality><ethnic inequity><ethnicity disparity><follow up><follow-up><followed up><followup><gene signatures><genetic signature><genome mutation><health care access><health care availability><health care service access><health care service availability><healthcare access><healthcare accessibility><healthcare availability><healthcare service access><healthcare service availability><improved><inequality due to race><inequity due to race><insight><intestinal epithelium><lymph cell><mRNA Degradation><mRNA Transcript Degradation><malignancy><malignant progenitor><malignant stem cell><member><metastatic colo-rectal><metastatic colo-rectal cancer><metastatic colo-rectal carcinoma><metastatic colon cancer><metastatic colorectal><metastatic colorectal cancer><metastatic colorectal carcinoma><mortality><muscular><neoplasm progression><neoplasm/cancer><neoplastic><neoplastic progression><neuronal><novel><oncogenomics><p53 Antigen><p53 Genes><p53 Tumor Suppressor><parent><patient oriented outcomes><personalized drugs><population health><precision drugs><progenitor><progenitor cell differentiation><progenitor cell regeneration><progenitor cell self renewal><progenitor differentiation><progenitor regeneration><progenitor self renewal><prospective><protein p53><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial minority><racial origin><racially unequal><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration potential><regenerative><regenerative cell><regenerative potential><repair><repaired><resistant><response><restoration><scRNA-seq><self-renew><self-renewal><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor differentiation><stem cell characteristics><stem cell differentiation><stem cell regeneration><stem cell self renewal><stem cells><stemness><therapeutic evaluation><therapeutic target><therapeutic testing><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptional reprogramming><treatment guidelines><tumor><tumor behavior><tumor cell metastasis><tumor initiation><tumor progression><v-Ki-RAS2 Kirsten Rat Sarcoma 2 Viral Oncogene Homolog><wound healing><wound recovery><wound resolution><xeno-transplant><xeno-transplantation>
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Gloria Vittone Echeverria

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Exploratory lead · 10/100
Active award
$240,000
FY 2025

Project Title

Metabolic adaptation in residual triple negative breast cancer following chemotherapy

Grant Number:

3R37CA269783-03S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/27/2022

End Date:

11/30/2027

Project Abstract

PROJECT SUMMARY TNBC is a subtype of breast cancer predominated by major health disparity. African American (AA) women have a disproportionately higher incidence of TNBC than do European American (EA) women. In fact, AA women are twice as likely to be diagnosed with TNBC as are women of other races....

Research Terms

<African><African American><African American Females><African American Women><African Females><African Women><African ancestry><African descent><Afro American><Afroamerican><American><Biological><Breast Cancer><Breast Cancer Patient><Breast Tumor Patient><Chemoresistance><Complex><Data><Data Set><Diagnosis><Disease><Disorder><Disparities><Disparity><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><European><Exhibits><Foundations><Gene Expression><Genetic><Germ Lines><Grant><Incidence><Knowledge><Malignant Breast Neoplasm><Mediator><Metabolic><Mitochondria><Molecular><Obesity><Oncogenic><Outcome><Parents><Patients><Race><Races><Refractory Disease><Research Specimen><Residual><Residual state><Role><Socioeconomically disadvantaged><Specimen><Stress><Structure><Survival Rate><TNBC><Tumor Cell><Woman><Work><adiposity><biologic><cancer microenvironment><chemoresistant><chemotherapy><chemotherapy resistance><chemotherapy resistant><co-morbid><co-morbidity><comorbidity><corpulence><develop therapy><disparities in race><disparity due to race><disparity in health><ethnic subgroup><ethnicity group><female outcomes><health disparity><individuals with breast cancer><inequality due to race><inequity due to race><intervention development><malignant breast tumor><mitochondrial><neoplastic cell><outcomes among females><outcomes among women><outcomes in females><outcomes in women><parent><patients with breast cancer><person with breast cancer><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial origin><racially unequal><response to therapy><response to treatment><social role><socio-economic disadvantage><socio-economically disadvantaged><socio-economically underprivileged><socioeconomic disadvantage><socioeconomically underprivileged><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic response><therapy development><therapy response><treatment development><treatment response><treatment responsiveness><triple-negative breast cancer><triple-negative invasive breast carcinoma><tumor microenvironment><women's outcomes>
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Erin Rogers

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Exploratory lead · 10/100
Active award
$226,794
FY 2023

Project Title

A behavioral economic intervention for low-income smokers - Resubmission - 1 - Revision - 1

Grant Number:

3R37CA252483-02S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/14/2021

End Date:

11/30/2026

Project Abstract

PROJECT SUMMARY People with low income face unique barriers to cessation, including high levels of financial distress, trauma, and unmet social needs, resulting in the use of smoking as a coping mechanism. Behavioral economics further finds that people experiencing financial hardship must attend to ...

Research Terms

<21+ years old><Address><Administrative Supplement><Adult><Adult Human><Application Context><Behavior><Communities><Counseling><Data><Data Analytics><Data Collection><Effectiveness><Effectiveness of Interventions><Environment><Ethnic Origin><Ethnicity><Face><Financial Hardship><Gender><Goals><Grant><Health><Health Benefit><Housing><Impoverished><Inadequate Sleep Hygiene><Individual><Intervention><Intervention Strategies><Interview><Knowledge><Latina><Latino><Literature><Low income><Maintenance><Measures><Neighborhoods><Outcome><Parents><Participant><Persons><Population><Poverty><Procedures><Process><Qualitative Methods><Race><Races><Randomized><Relapse><Risk><Services><Smoke><Smoker><Smoking><Smoking Cessation Intervention><Social Identification><Social Identity><Social Service><Social Work><Stigmatization><Structure><Survey Instrument><Surveys><Tobacco Consumption><Tobacco use><Trauma><Woman><Work><adulthood><assess effectiveness><behavior change><behavioral economics><black female><black male><black men><black women><cease smoking><contextual factors><coping mechanism><cost effectiveness><design><designing><determine effectiveness><disparities in income><effectiveness assessment><effectiveness evaluation><empowerment><evaluate effectiveness><examine effectiveness><experience><faces><facial><financial burden><financial distress><financial strain><financial stress><food insecurity><group intervention><improved><income disparities><insight><intersectionalities><intersectionality><intervention participants><interventional strategy><marginalization><men><novel><parent><parent project><participant enrollment><patient enrollment><poor sleep hygiene><qualitative reasoning><quality of sleep><quit smoking><racial><racial background><racial origin><randomisation><randomization><randomly assigned><resilience><resilient><response><sleep quality><smoking cessation><smoking cessation treatment><social><social determinants><social factors><sociodeterminant><stop smoking><structural determinants><structural factors><theories><tobacco cessation intervention><tobacco cessation treatment><tobacco product use><women of color>
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DEBRA J. UMBERSON

UNIVERSITY OF TEXAS AT AUSTIN, AUSTIN, TX

Exploratory lead · 10/100
Active award
$100,000
FY 2023

Project Title

How Spouses Influence Each Other's Health in Same- and Different-Sex Marriages: A Dyadic and Longitudinal Assessment from Mid to Later Life

Grant Number:

3R37AG076057-02S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2022

End Date:

12/31/2026

Project Abstract

Abstract Decades of population research show that married Americans are in better health and live longer than their unmarried peers and that there are gender differences in how spouses influence each other’s health. The Parent project has moved us beyond work on health in different-sex marriages bet...

Research Terms

<21+ years old><Address><Administrative Supplement><Adult><Adult Human><Alcohol Drinking><Alcohol consumption><American><Attention><Bi-sexual><Bisexual><Couples><Data><Decrease health disparities><Disadvantaged><Elderly><EtOH drinking><EtOH use><Family member><Foundations><Future><Gays><Gender><Gender Relations><Goals><Health><Health behavior><Health disparity mitigation><Health disparity reduction><Heterosexuals><Individual><Interview><Investigation><LGBTQ><Lesbian><Lesbian Gay Bi-sexual Transgender Queer><Lesbian Gay Bisexual Transgender Queer><Life Cycle><Life Cycle Stages><Literature><Longitudinal Surveys><Lower health disparities><Marital Relationships><Marriage><Married Persons><Measures><Mental Health><Mental Hygiene><Mitigate health disparities><NIH><National Academy of Sciences><National Institutes of Health><Outcome><Parents><Pathway interactions><Pattern><Personal Satisfaction><Persons><Policy Maker><Population><Population Research><Population-based research><Population-level research><Process><Psychological Health><Reduce health disparities><Same-sex><Sampling><Scientist><Sexual Health><Sexuality><Spouses><Stress><Survey Instrument><Surveys><Thinking><United States National Academy of Sciences><United States National Institutes of Health><Unmarried><Woman><Work><adulthood><advanced age><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><diaries><disparity in health><elders><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><experience><gender difference><gender-associated difference><geriatric><health disparity><health related behavior><insight><interest><late life><later life><life course><men><mid life><mid-life><middle age><middle aged><midlife><novel><older adult><older person><pansexual><parent><parent project><pathway><peer><physical conditioning><physical health><poor health outcome><queer><recruit><reduced health outcome><response><senior citizen><sex><sexual identity><sexual minority><sexual minority group><sexual minority individual><sexual minority people><sexual minority population><social relationships><theories><thoughts><well-being><wellbeing><worse health outcome>
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Prabodh Kumar Pandey

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 10/100
Active award
$80,229
FY 2025

Project Title

Quantitative in vivo dosimetry for radiotherapy using model-based X-ray-induced acoustic computed tomography

Grant Number:

5R50CA283816-02

Activity Code:

R50

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/3/2024

End Date:

8/31/2029

Project Abstract

Abstract Accurate dose delivery at the tumor site is crucial for the success of radiotherapy (RT) for cancer treatment. However, as yet there are no techniques in clinics with the ability to monitor RT. This project proposes X-ray- induced acoustic (XA) computed tomography (XACT) to facilitate dose ...

Research Terms

<Acceleration><Acoustics><Address><Adopted><Advanced Instrumentation><Affect><Algorithms><American Cancer Society><Artifacts><Award><Biomedical Computing><Body Tissues><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><Cancer Radiotherapy><Cancer Treatment><Cell Communication and Signaling><Cell Signaling><Characteristics><Clinic><Clinical><Clinical Paths><Clinical Pathways><Computed Tomography><Computer Instrumentation><Computers and Advanced Instrumentation><Creativeness><Deposit><Deposition><Dose><Funding><Goals><Grant><H+ element><Heterogeneity><Human Resources><Hydrogen Ions><Intracellular Communication and Signaling><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Manpower><Maps><Modality><Modeling><Monitor><Morphologic artifacts><NIH><National Institutes of Health><Noise><Physics><Physiologic pulse><Principal Investigator><Protons><Pulse><Qualifying><Radiation Dosimetry><Radiation therapy><Radiography><Radiometry><Radiotherapeutics><Radiotherapy><Research><Roentgen Rays><Roentgenography><Scientist><Seasons><Signal Transduction><Signal Transduction Systems><Signaling><Site><Techniques><Time><Tissues><Tomodensitometry><Transducers><Ultrasonic Transducer><Ultrasound transducer><United States National Institutes of Health><X-Radiation><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><X-Ray Radiation><X-ray><Xray><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><absorption><anti-cancer therapy><biological signal transduction><biomedical computation><biomedical imaging><cancer radiation therapy><cancer therapy><cancer-directed therapy><catscan><clinical translation><clinically translatable><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><creativity><dose information><dosimetry><experience><image construction><image generation><image reconstruction><in vivo><next generation><non-contrast CT><noncontrast CT><noncontrast computed tomography><parallelization><personnel><post-doctoral training><proton beam><proton therapy><radiation treatment><radioassay><radiological imaging><reconstruction><success><tomography><treatment with radiation><tumor>
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Stephen Shiu-Wah Chung

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Exploratory lead · 10/100
Active award
$67,237
FY 2024

Project Title

Diversity Supplement for R37 Grant

Grant Number:

3R37CA273232-02S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/21/2023

End Date:

8/31/2028

Project Abstract

Summary/Abstract This proposal is for a Diversity Supplement to R37CA273232 to support a graduate student Benjamin Kroger. Below is the abstract for the parent award, and as part of this diversity supplement, Mr. Kroger will be contributing to studies performing ribosome profiling to identify key LSC...

Research Terms

<AML - Acute Myeloid Leukemia><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><Adopted><B cell lymphoma 2><B-Cell CLL/Lymphoma 2 Gene><B-cell lymphoma/leukemia-2><BCL2><BCL2 gene><Bcl-2><Biogenesis><Blood Precursor Cell><Cancers><Cell Body><Cell surface><Cells><Clinical><Dependence><Development><Evaluation><Exhibits><GEM model><GEMM model><Genetic><Genetically Engineered Mouse><Goals><Grant><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Human><Impairment><Knowledge><Leukemic progenitor and stem cell><Link><Maintenance><Malignant Neoplasms><Malignant Tumor><Modeling><Modern Man><Origin of Life><Outcome><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Protein Biosynthesis><Protein Synthesis Inhibition><Proteins><Regulation><Research><Ribo-seq><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Ribosomes><Role><Stem Cell like><Testing><Translating><Tumor Suppressor Proteins><acute granulocytic leukemia><acute myeloid leukemia><bcl-2 Genes><biological adaptation to stress><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cancer progenitor><cancer progenitor cells><cancer stem cell><ced9 homolog><design><designing><develop therapy><developmental><effective therapy><effective treatment><genetically engineered mouse model><genetically engineered murine model><graduate student><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><high risk><improved><inhibitor><innovate><innovation><innovative><insight><intervention development><leukemic progenitor><leukemic stem cell><malignancy><malignant progenitor><malignant stem cell><mouse model><murine model><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><overexpress><overexpression><parent award><parent project><patient oriented outcomes><prevent><preventing><progenitor cell function><progenitor cell model><progenitor cell regeneration><progenitor cell self renewal><progenitor function><progenitor model><progenitor regeneration><progenitor self renewal><protein synthesis><reactioncrisis><resistance to therapy><resistant to therapy><response><ribosome footprint profiling><ribosome profiling><self-renew><self-renewal><social role><stem and progenitor cell function><stem and progenitor cell model><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor function><stem cell based model><stem cell characteristics><stem cell derived model><stem cell function><stem cell model><stem cell regeneration><stem cell self renewal><stemness><stress response><stressreaction><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic resistance><therapy development><therapy resistant><treatment development><treatment resistance><tumor suppressor>
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Matthew D Stachler

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 10/100
Active award
$38,478
FY 2024

Project Title

Optimization and validation of a biomarker panel for risk stratification in Barrett's esophagus

Grant Number:

3R37CA269649-02S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

11/30/2027

Project Abstract

Project Summary: Intestinalization of the esophagus, termed Barrett’s esophagus (BE), is thought to develop in response to chronic acid and bile reflux and carries great clinical significance because it is the precursor to esophageal adenocarcinoma (EAC). The incidence of BE is quite high, estimated...

Research Terms

<Acid Reflux><Adenocarcinoma of the Esophagus><American><Assay><Barrett Esophagus><Barrett Syndrome><Barrett Ulcer><Bile Reflux><Bioassay><Biological Assay><Biological Markers><Cancers><Chronic><Columnar Epithelial-Lined Lower Esophagus><Columnar-Lined Esophagus><DNA copy number><Data><Data Analyses><Data Analysis><Diagnosis><Doctor of Philosophy><Dysplasia><Early Diagnosis><Esophageal Adenocarcinoma><Esophageal Cancer><Esophageal Reflux><Esophageal Tissue><Esophagus><Esophagus Cancer><GERD><Gastro-oesophageal Reflux><Gastroesophageal Reflux><Gastroesophageal reflux disease><Goals><Incidence><Intestinal><Intestines><Investigators><Laboratories><Lesion><Malignant Esophageal Neoplasm><Malignant Esophageal Tumor><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Esophagus><Malignant neoplasm of esophagus><Mentors><Mentorship><Methods><Methylation><Molecular><Parents><Patients><Persons><Ph.D.><PhD><Preparation><Process><Research><Research Personnel><Researchers><Risk><Scientist><Training><Validation><bio-markers><biologic marker><biomarker><biomarker array><biomarker panel><bowel><cancer genomics><career development><clinical significance><clinically significant><data interpretation><disease risk><disorder risk><dyscrasia><early detection><esophageal intestinal metaplasia><graduate school><high risk><improved><malignancy><marker panel><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><oesophageal cancer><oncogenomics><parent><patient stratification><precancer><precancerous><premalignant><preparations><programs><progression risk><response><retrograde bile flow><risk stratification><stratified patient><stratify risk><validations>
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Carolyn Bertozzi

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 10/100
Active award
$34,169
FY 2025

Project Title

Chemical Mycobateriology

Grant Number:

3R37AI051622-24S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2026

Project Abstract

Tuberculosis (TB) is a chronic pulmonary disease caused by Mycobacterium tuberculosis (Mtb), which infects approximately one quarter of the world’s population. A variety of drugs have been identified that rapidly kill Mtb and its relatives in vitro, yet clinical treatment requires at least 6 months ...

Research Terms

<Adamantane><Address><Affinity><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antigens><Antitubercular Drugs><Bacteria><Bacterial Infections><Biological><Biology><Brachydanio rerio><Cell Body><Cell Culture Techniques><Cell Survival><Cell Viability><Cells><Chemicals><Chronic lung disease><Clinical><Clinical Treatment><Collaborations><Coloring Agents><Combined Modality Therapy><Complex><Danio rerio><Detection><Development><Diagnostic Reagent><Diamantane><Drug Screening><Drug Therapy><Drugs><Dyes><Fluorescence><Frustration><Funding><Generalized Growth><Generations><Genetic><Glean><Grant><Growth><HIV/Mtb><HIV/TB><HIV/mycobacterium tuberculosis><HIV/tuberculosis><Hour><Image><In Vitro><Infection><Innate Immunity><Instruction><Investigation><Knock-out><Knockout><Label><Libraries><Lipids><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><M marinum><M tb><M tuberculosis><M tuberculosis infection><M. marinum><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M. tuberculosis/HIV><M.tb infection><M.tuberculosis infection><MTB infection><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Medication><Membrane><Metabolic><Methods><Microscope><Microscopy><Miscellaneous Antibiotic><Modeling><Molecular><Multimodal Therapy><Multimodal Treatment><Mycobacterial Infection><Mycobacterium Infections><Mycobacterium marinum><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Participant><Patients><Performance><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Population><Protocol><Protocols documentation><Proxy><Reagent><Regimen><Resistance><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Role><Sampling><South Africa><Sputum><Structure><System><TB diagnosis><TB drugs><TB infection><TB therapy><TB treatment><Time><Tissue Growth><Trehalose><Tuberculosis><Tuberculosis diagnosis><Virulence><Visualization><Work><Zebra Danio><Zebra Fish><Zebrafish><active method><active technique><active treatment><analog><anti-TB drugs><anti-tuberculosis drugs><bacteria infection><bacterial disease><biologic><cell culture><cell cultures><chronic pulmonary disease><clinical intervention><clinical therapy><combination therapy><combined modality treatment><combined treatment><cost><detection method><detection procedure><detection technique><developmental><diagnosed with TB><diagnosed with Tuberculosis><disseminated TB><disseminated tuberculosis><drug intervention><drug treatment><drug/agent><ebselen><global health><high-throughput drug screening><imaging><immunogen><infection due to Mycobacterium tuberculosis><inhibitor><insight><magnetic beads><membrane structure><model organism><mtb><multi-modal therapy><multi-modal treatment><mycobacterial><next generation><nile red><ontogeny><pathogen><performance tests><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><point of care><point-of-care diagnostics><resistant><screening><screenings><social role><supply chain><treat M. tuberculosis><treat Mtb><treat Mycobacterium tuberculosis><treat tb><treat tuberculosis><trial regimen><trial treatment><tuberculosis drugs><tuberculosis infection><tuberculosis therapy><tuberculosis treatment><tuberculous spondyloarthropathy>
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Lucy Liaw

MAINEHEALTH, PORTLAND, ME

Exploratory lead · 8/100
Team-scale grant
$249,000
FY 2021

Project Title

COBRE in Mesenchymal and Neural Regulation of Metabolic Networks - Metabolic Phenotyping Equipment

Grant Number:

3P20GM121301-05S1

Activity Code:

P20

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/1/2017

End Date:

8/31/2023

Project Abstract

Abstract Whole body metabolism is regulated by integration of multiple tissues, including adipose tissue, the skeleton, and bone marrow. Imbalanced regulation of these tissues leads to prevalent, chronic disorders, obesity and osteoporosis. Adipocyte precursors and osteoprogenitor cells share a comm...

Research Terms

<Address><Adipocytes><Adipose Cell><Adipose tissue><Administrative Supplement><Aging><Behavior monitoring><Behavioral><Biochemical Pathway><Bioenergetics><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Tissue><Brown Adipose Tissue><Brown Fat><CNS Nervous System><COBRE><Cell Communication and Signaling><Cell Signaling><Center of Biomedical Research Excellence><Centers of Research Excellence><Central Nervous System><Chronic Disease><Chronic Illness><Controlled Study><Core Facility><Development><Disease><Disorder><Enhancement Technology><Equipment><Fat Cells><Fatty Tissue><Fracture><Funding><Genetic><Goals><Health><Hibernating Gland><Histopathology><Human><Intermediary Metabolism><Intracellular Communication and Signaling><Investigators><Lipocytes><Martes zibellina><Mature Lipocyte><Mature fat cell><Mesenchymal><Metabolic><Metabolic Networks><Metabolic Processes><Metabolism><Modern Man><Molecular><NIH><National Institutes of Health><Neuraxis><Nutritional><Obesity><Osteoporosis><Physiology><Pilot Projects><Play><Process><Productivity><Proteomics><Regulation><Research><Research Personnel><Researchers><Risperidone><Role><Sable><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Skeleton><Stress><Sympathetic Nervous System><System><Temperature><Testing><Tissues><United States National Institutes of Health><adipogenesis><adipose><adiposity><atypical antipsychotic><behavior phenotype><behavioral monitoring><behavioral phenotyping><biological signal transduction><bone fracture><bone loss><brain tissue><chronic disorder><corpulence><developmental><fracture risk><iPS><iPSC><iPSCs><induced pluripotent stem cell><lipid biosynthesis><lipidomics><lipogenesis><metabolic phenotype><metabotype><mouse model><murine model><neural control><neural regulation><neuromodulation><neuromodulatory><neuroregulation><novel><nutritious><osteoblast cell differentiation><osteoblast differentiation><osteoblastic differentiation><osteoprogenitor><osteoprogenitor cell><pilot study><precursor cell><programs><recruit><resperidone><skeletal><skeletal progenitor><social role><treadmill><white adipose tissue><yellow adipose tissue>
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E. Michael Ostap

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 0/100
$200,000
FY 2023

Project Title

Molecular function of Myosin-l

Grant Number:

3R37GM057247-25S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/1998

End Date:

11/30/2025

Project Abstract

SUMMARY The goal of the parent R37 project is to determine the molecular mechanisms of the myosin-I family of motors. Myosin-Is comprise the largest unconventional myosin family found in humans, and its large size and expression profile distinguish it as one of the most diverse. Myosin-Is physically...

Research Terms

<20 year old><20 years of age><Acceleration><Actin-Activated ATPase><Actins><Adaptor Protein><Adaptor Protein Gene><Adaptor Signaling Protein><Adaptor Signaling Protein Gene><Address><Award><Binding><Cell Communication and Signaling><Cell Function><Cell Locomotion><Cell Membrane Lipids><Cell Migration><Cell Movement><Cell Process><Cell Signaling><Cell membrane><Cell physiology><Cellular Function><Cellular Matrix><Cellular Mechanotransduction><Cellular Migration><Cellular Motility><Cellular Physiology><Cellular Process><Computer software><Cytoplasmic Membrane><Cytoskeletal Gene><Cytoskeletal Proteins><Cytoskeletal System><Cytoskeleton><Data><Development><Equipment><Event><Family><Funding><Goals><Health><Human><Intracellular Communication and Signaling><Investigators><Kinetics><Label><Life><Link><Manufacturer><Mechanical Signal Transduction><Mechanosensory Transduction><Mediating><Membrane><Membrane Lipids><Microscope><Modern Man><Molecular><Molecular Interaction><Molecular Motors><Motility><Motor><Myosin ATPase><Myosin Adenosine Triphosphatase><Myosin Adenosinetriphosphatase><Myosin I><Myosin Type I><Myosins><Normal Cell><Parents><Pathway interactions><Plasma Membrane><Play><Polymers><Proteins><Regulation><Research><Research Personnel><Researchers><Role><Running><Signal Transduction><Signal Transduction Systems><Signaling><Software><Subcellular Process><System><TIRF Microscopy><Total Internal Reflection Fluorescent><Total Internal Reflection Fluorescent Microscopy><Touch><Touch sensation><Tropomyosin><adapter protein><age 20 years><biological signal transduction><cell motility><developmental><experiment><experimental research><experimental study><experiments><instrument><intracellular skeleton><mechanosensing><mechanotransduction><membrane structure><parent><pathway><plasmalemma><polymer><polymeric><polymerization><single molecule><social role><synergism><tactile sensation><temporal measurement><temporal resolution><therapeutic target><time measurement><trafficking><twenty year old><twenty years of age>
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James N. Odom

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 0/100
$170,159
FY 2021

Project Title

Lay Coach-led Early Palliative Care for Underserved Advanced Cancer Caregivers

Grant Number:

3R37CA252868-02S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2020

End Date:

6/30/2025

Project Abstract

SUPPLEMENT PROJECT SUMMARY This application (a Diversity Supplement to Dr. James N. Dionne-Odom’s parent award entitled, “Lay Coach-led Early Palliative Care for Underserved Advanced Cancer Caregivers”) describes the background and experience of the applicant, Erin R. Harrell, PhD and her plan to ac...

Research Terms

<Advanced Cancer><Advanced Malignant Neoplasm><African American><Afro American><Afroamerican><Attitude><Award><Bereavement><Black Populations><Cancers><Care Givers><Care giver support><Caregiver support><Caregivers><Cessation of life><Death><Development><Diagnosis><Disease Progression><Doctor of Philosophy><Family><Family Care Giver><Family Caregiver><Feedback><Foundations><Goals><Health><Intervention><Intervention Strategies><Interview><Investigators><Knowledge><Lead><Leadership><Malignant Neoplasms><Malignant Tumor><Methods><Outcome><Palliative Care><Palliative Therapy><Palliative Treatment><Parents><Patient Care><Patient Care Delivery><Patients><Pb element><Persons><Ph.D.><PhD><Phase><Qualitative Research><Reporting><Research><Research Personnel><Researchers><Risk Factors><Training><base><black American><cancer related cognitive decline><cancer related cognitive dysfunction><cancer-related cognitive impairment><care receiver><care recipients><comfort care><community engagement><design><designing><develop therapy><developmental><end of life><end-of-life><experience><family care giving><family caregiving><heavy metal Pb><heavy metal lead><improved><intervention development><interventional strategy><malignancy><motivational enhancement therapy><motivational interview><neoplasm/cancer><psychological distress><public health priorities><skills><therapy development><treatment development>
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Kenneth Alan Freedberg

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 0/100
$164,613
FY 2023

Project Title

Optimizing HIV Care in Less Developed Countries

Grant Number:

3R37AI058736-18S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2004

End Date:

8/22/2023

Project Abstract

Project Summary/Abstract Despite improved access to HIV testing and antiretroviral therapy over the past decade, people with HIV globally continue to experience high mortality from HIV-associated infections such as cryptococcal meningitis. Cryptococcal meningitis causes more than 90,000 deaths annua...

Research Terms

<5-FC><5-Fluorocytosine><AIDS><AIDS Virus><AIDS test><AIDS/HIV test><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immuno-Deficiency Syndrome><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Acquired Immunologic Deficiency Syndrome><Active Follow-up><Address><Administrative Supplement><Africa South of the Sahara><Alcobon><AmB><AmBisome><Amphocil><Amphotec><Amphotercin B><Amphotericin B><Ancobon><Ancotil><Antigens><Bacterial Infections><Budgets><Caring><Cause of Death><Cessation of life><Chronic><Clinical><Clinical Management><Clinical Trials><Computers><Continuity of Care><Continuity of Patient Care><Continuum of Care><Costs and Benefits><Country><Cryptococcal Meningitis><Cryptococcus><Data><Death><Developing Countries><Developing Nations><Development><Development and Research><Diagnostic><Diagnostic tests><Disease><Disorder><Drug Costs><Drugs><Equipment><Flucytosine><Funding><Fungizone><Goals><Guidelines><HIV><HIV test><HIV-1 test><HIV-2 test><Health><Hospital Costs><Hospitalization cost><Human Immunodeficiency Viruses><Human immunodeficiency virus test><Improve Access><Individual><Infection><International><Intervention><Intervention Strategies><Investments><LAV-HTLV-III><Less-Developed Countries><Less-Developed Nations><Liposomal><Liposomes><Literature><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Lumbar Puncture><Lymphadenopathy-Associated Virus><Medication><Modeling><Mysteclin-F><Natural History><Opportunistic Infections><Outcome><Parents><Persons><Pharmaceutic Preparations><Pharmaceutical Preparations><Policies><Policy Maker><Preventative strategy><Prevention strategy><Preventive strategy><Publishing><R & D><R&D><Recommendation><Research><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Safety><South Africa><Specificity><Spinal Puncture><Structure><Sub-Saharan Africa><Subsaharan Africa><Testing><Third-World Countries><Third-World Nations><Torula><Training><Treatment Efficacy><Treatment Protocols><Treatment Regimen><Treatment Schedule><Under-Developed Countries><Under-Developed Nations><Virus-HIV><World Health Organization><access gaps><active followup><anti-retroviral therapy><anti-retroviral treatment><antiretroviral therapy><antiretroviral treatment><bacteria infection><bacterial disease><cost><cost effectiveness><developing country><developing nation><developmental><drug/agent><effective therapy><effective treatment><effectiveness testing><experience><flexibility><flexible><fluorocytosine><follow up><follow-up><followed up><followup><gaps in access><health assessment><immunogen><improved><improved outcome><intervention efficacy><interventional strategy><lateral flow assay><lateral flow test><model-based simulation><models and simulation><mortality><novel><parent><prevent><preventing><research and development><scale up><simulation><therapeutic efficacy><therapy efficacy><treatment strategy><uptake>
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Andrew S. Borovik

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 0/100
$120,913
FY 2023

Project Title

Hydrogen Bonding Cavity Motifs About Metal Ions

Grant Number:

3R37GM050781-31S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/1994

End Date:

12/31/2025

Project Abstract

PROJECT SUMMARY (from current award 5 R37 GM050781-26) The broad purpose of the research in this proposal is to understand how microenvironments (secondary coordination spheres) about metal ions control function. A bio-inspired synthetic approach is utilized that incorporates principles of molecular...

Research Terms

<Active Sites><Address><Affect><Aging><Architecture><Area><Award><Binding><Biochemical Process><Biological><Biology><Catalysis><Characteristics><Chemicals><Chemistry><Complex><Cytochrome c Peroxidase><Dioxygen><Dysfunction><Engineering / Architecture><Exhibits><Functional disorder><Goals><Grant><H-bond><Health><Human><Hydrogen Bonding><Hydrogen Oxide><Hydroxylation><Individual><Investigation><Ions><Knowledge><Ligands><Link><Maintenance><Mediating><Medical><Metal Binding Site><Metalloproteins><Metals><Modern Man><Modification><Molecular><Molecular Interaction><Oxidation-Reduction><Physiopathology><Process><Property><Proteins><Reaction><Redox><Research><Shapes><Site><Structure><Structure-Activity Relationship><System><Transition Elements><Water><biologic><catalyst><chemical property><chemical structure function><improved><insight><metal complex><metalloenzyme><oxidation><oxidation reduction reaction><pathophysiology><physical property><scaffold><scaffolding><small molecule><structural biology><structure function relationship><transition metal>
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VIJAY H. SHAH

MAYO CLINIC ROCHESTER, ROCHESTER, MN

Exploratory lead · 0/100
$120,102
FY 2021

Project Title

Molecular Mechanisms of Liver Fibrosis (Diversity Supplement)

Grant Number:

3R37AA021171-10S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/10/2012

End Date:

4/30/2022

Project Abstract

Project Summary/Abstract This diversity supplement to the NIAAA R37 grant is in support of the candidate Dr. Amani Lee. Dr. Amani Lee will pharmacologically inhibit epigenetic regulators of the mobility and matrix formation of hepatic stellate cells (HSCs). He will work with both commercial inhibito...

Research Terms

<Affect><Alcohol Chemical Class><Alcohols><Applications Grants><Biomedical Research><Cellular biology><Chemistry><Cirrhosis><Clinical><DNA Molecular Biology><Development><Development Plans><Disease model><Doctor of Philosophy><Educational workshop><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Fibrosis><Goals><Grant><Grant Proposals><Hepatic Disorder><Hepatic Stellate Cell><Ito Cell><Journals><Knowledge><Lead><Learning><Liver Fibrosis><Liver diseases><Magazine><Mentors><Methodology><Minnesota><Molecular><Molecular Biology><Molecular Genetics><Morbidity><Morbidity - disease rate><NIAAA><NIH><National Institute on Alcohol Abuse and Alcoholism><National Institutes of Health><Paper><Pb element><Ph.D.><PhD><Pharmacology><Prevention><Publications><Regulatory Pathway><Scientific Publication><Techniques><Training><Translating><United States National Institutes of Health><Universities><Work><Workshop><alcohol abuse therapy><alcohol abuse treatment><alcohol treatment><base><biological systems><career development><cell biology><cirrhotic><clinical applicability><clinical application><conference><convention><design><designing><developmental><disorder model><experiment><experimental research><experimental study><fibrogenesis><fibrotic liver><frontier><heavy metal Pb><heavy metal lead><hepatic disease><hepatic fibrosis><hepatopathy><inhibitor><inhibitor/antagonist><liver disorder><meetings><member><migration><mortality><novel><public health relevance><summit><symposia><symposium><tool>
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Kristopher Andrew Sarosiek

HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH, BOSTON, MA

Exploratory lead · 0/100
$90,053
FY 2024

Project Title

Developmental regulation of apoptosis as a modifiable driver of radiotherapy-induced neurocognitive impairment in pediatric patients

Grant Number:

3R37CA248565-05S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/9/2020

End Date:

2/28/2025

Project Abstract

CNS cancers account for 26% of pediatric cancers and are the leading cause of cancer deaths and morbidity. Medulloblastoma, the most common CNS cancer in children, is typically treated with high doses of external beam radiation therapy (xRT) and surgery. However, xRT induces apoptosis (programmed ce...

Research Terms

<0-11 years old><21+ years old><ANX5><ANX5 Gene><ANXA5><ANXA5 gene><Adult><Adult Human><Age><Anchorin CII><Anchorin CII Gene><Animals><Annexin A5 Gene><Annexin A5 Protein><Annexin V><Apopain><Apoptosis><Apoptosis Pathway><Apoptosis-Related Cysteine Protease Caspase 3><Apoptotic><Assay><Astrocytes><Astrocytus><Astroglia><Automobile Driving><Award><B-Cell Chronic Lymphocytic Leukemia Associated Oncogene><B-cell Leukemia 1><B-cell lymphoma-extra large><BAX><BAX Isoform Alpha><BAX gene><BCL><BCL-XL><BCL1 Oncogene><BCL2-Associated X Protein><BCL2-Associated X Protein Gene><BCL2-Like 1><BCL2-Related Gene><BCL2-Related Protein, Long Isoform><BCL2-Related Protein, Short Isoform><BCL2L1><BCL2L1 gene><BCL2L11 protein><BCL2L4><BCLX><BCLXL><BCLXS><BIM Bcl-2-binding protein><BIM protein><Bax protein><Bcl-2-interacting mediator of cell death><Bioassay><Biological Assay><Brain><Brain Nervous System><CASP-3><CASP3><CASP3 gene><CBP-I><CNS Cancer><CPP-32><CPP32><CPP32 protein><CPP32B><CPP32beta><Calphobindin I><Cancer Biology><Cancer Cause><Cancer Etiology><Cancer Survivor><Cancerous><Cell Body><Cell Communication and Signaling><Cell Death><Cell Differentiation><Cell Differentiation process><Cell Line><Cell Signaling><CellLine><Cells><Cellular Stress><Cellular Stress Response><Central Nervous System Cancer><Cessation of life><Child><Child Youth><Childhood><Childhood Cancers><Children (0-21)><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Collecting Cell><Communication><Cysteine Protease CPP32><Cysteine Protease CPP32 Gene><DNA Molecular Biology><Death><Definitive Radiation Therapy><Dephosphorylation><Development><Developmental Process><Differentiation in cell culture><Dissociation><Disturbance in cognition><Dose><Dysfunction><EBRT><ENX2><ENX2 Gene><Encephalon><Endonexin II><Endonexin II Gene><External Beam RT><External Beam Radiation Therapy><External Radiation><Functional disorder><Gene Transcription><Genes><Genetic Transcription><Goals><Hour><Human><IQ Deficit><Immunoblotting><Impaired cognition><In Vitro><In vitro cell differentiation><Induction of Apoptosis><Intracellular Communication and Signaling><Ionizing Electromagnetic Radiation><Ionizing radiation><Knowledge><Link><Lipocortin V Gene><Lipocortin-V><Malignant CNS Neoplasms><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant Tumor of the CNS><Malignant Tumor of the Central Nervous System><Malignant childhood cancer><Malignant neoplasm of central nervous system><Measures><Medulloblastoma><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Biology><Molecular Biology Techniques><Morbidity><Morbidity - disease rate><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neural Stem Cell><Neurocognitive Deficit><Neurocyte><Neuronal Differentiation><Neurons><Neuroprotectants><Neuroprotective Agents><Neuroprotective Drugs><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Operative Procedures><Operative Surgical Procedures><PAP-I><PARP Cleavage Protease><PARP Cleavage Protease Gene><PP4 Gene><Pathway interactions><Physiopathology><Placental Anticoagulant Protein I><Placental Protein 4><Play><Predisposition><Programmed Cell Death><Protein Dephosphorylation><Protein Family><Proteins><QOL><Quality of life><RNA Expression><Radiation Biology><Radiation Dose><Radiation Dose Unit><Radiation exposure><Radiation therapy><Radiation-Induced Change><Radiation-Ionizing Total><Radiobiology><Radiotherapeutics><Radiotherapy><Regulation><Research><Research Resources><Resistance><Resources><Role><SCA-1><SCA-1 Gene><SREBP Cleavage Activity 1><SREBP Cleavage Activity 1 Gene><Short interfering RNA><Signal Transduction><Signal Transduction Systems><Signaling><Small Interfering RNA><Strains Cell Lines><Students><Surgical><Surgical Interventions><Surgical Procedure><Susceptibility><Testing><Thromboplastin Inhibitor><Time><Toxic effect><Toxicities><Toxicology><Training><Transcription><Undifferentiated><VAC-Alpha><Vascular Anticoagulant-Alpha><Western Blotting><Western Immunoblotting><Work><Yama><Yama protein><adulthood><age associated><age correlated><age dependent><age linked><age related><age specific><ages><annexin A5><astrocytic glia><biological signal transduction><brain tissue><cancer in a child><cancer in children><cancer of the central nervous system><career><caspase-3><cell stress><cell type><cellular differentiation><child patients><child with cancer><childhood malignancy><cognitive defects><cognitive development><cognitive dysfunction><cognitive loss><cultured cell line><cysteine protease P32><developmental><differentiation in culture><differentiation in vitro><driving><experience><external-beam radiation><graduate student><improved><in vitro cellular differentiation><intelligence quotient deficit><ionizing output><kids><knock-down><knockdown><necrocytosis><nerve stem cell><neural circuit><neural circuitry><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neurocircuitry><neurocognitive decline><neurocognitive impairment><neurodevelopment><neuron progenitors><neuron toxicity><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuronal toxicity><neuroprogenitor><neuroprotection><neuroprotective><neurotoxicity><neurotoxicology><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><parent grant><pathophysiology><pathway><pediatric><pediatric cancer><pediatric malignancy><pediatric patients><pro-apoptotic protein><protein blotting><protein expression><radiation treatment><resistant><response><siRNA><skills><social role><surgery><synaptic circuit><synaptic circuitry><treatment with radiation><youngster>
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Michaela R. Reagan

MAINEHEALTH, PORTLAND, ME

Exploratory lead · 0/100
$79,077
FY 2024

Project Title

Defining the Roles of Bone Marrow Adipocytes and FABP4/5 Signaling in Multiple Myeloma Drug Resistance - Diversity Supplement

Grant Number:

3R37CA245330-05S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2020

End Date:

3/7/2025

Project Abstract

ABSTRACT The overall goal of this Supplemental research project is to support the career development of Michelle Karam, who is a post-baccalaureate research assistant in the Reagan lab planning to go to graduate school in biomedical science. Multiple myeloma (MM) is an incurable blood cancer that re...

Research Terms

<3-D><3-Dimensional><3D><A-FABP><Adipocytes><Adipose Cell><Automobile Driving><Award><Blood Plasma Cell><Bone Marrow><Bone Marrow Reticuloendothelial System><Cancer Model><CancerModel><Career Choice><Career Path><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Expansion><Cellular Growth><Clinic><Complement><Complement Proteins><Data Analyses><Data Analysis><Development><Dose><Drug Delivery><Drug Delivery Systems><Drug resistance><E-FABP><Environment><FABP4><FABP4 gene><FABP5><FABP5 gene><Fat Cells><Fatty Acid Binding Protein 4, Adipocyte><Generalized Growth><Genetic Alteration><Genetic Change><Genetic defect><Goals><Grant><Growth><Guidelines><Hematopoietic Cell Tumor><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Immune><Immunes><Immunocompetent><Intracellular Communication and Signaling><KFABP><Lipocytes><Malignant Hematopoietic Neoplasm><Mature Lipocyte><Mature fat cell><Mediator><Methodology><Methods><Mice><Mice Mammals><Modeling><Multiple Myeloma><Murine><Mus><Mutation><NIH><National Institutes of Health><Oral><Oral Administration><Oral Drug Administration><PA-FABP><Parents><Patients><Plasma Cells><Plasma-Cell Myeloma><Plasmacytes><Postbaccalaureate><Proliferating><Proteins><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Assistant><Research Grants><Research Project Grants><Research Projects><Role><Route><Science><Signal Transduction><Signal Transduction Systems><Signaling><Soil><Time><Tissue Engineering><Tissue Growth><Tumor Cell><Underrepresented Ethnic Minority><Underrepresented Minority><United States National Institutes of Health><Work><bioengineered tissue><biological signal transduction><blood cancer><bone><cancer microenvironment><cancer of blood><cancer of the blood><cancer progression><career aspiration><career development><career interest><career pathway><career track><cell growth><clinical relevance><clinically relevant><complementation><data interpretation><developmental><driving><drug development><drug resistant><engineered tissue><falls><fatty acid-binding proteins><feasibility testing><genome mutation><graduate school><immune competent><immune microenvironment><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><in vivo><inhibitor><insight><intraoral drug delivery><member><mouse model><murine model><myeloma><myelomatosis><neoplasm progression><neoplastic cell><neoplastic progression><new approaches><novel><novel approaches><novel strategies><novel strategy><ontogeny><parent><parent award><parent project><plasmocyte><postbac><postbacc><resistance to Drug><resistant to Drug><social role><three dimensional><transcriptomics><tumor><tumor immune microenvironment><tumor microenvironment><tumor progression><tumor-immune system interactions><under-representation of minorities><under-represented minority><underrepresentation of minorities>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Karuna Ganesh

SLOAN-KETTERING INST CAN RESEARCH, NEW YORK, NY

Exploratory lead · 0/100
$76,187
FY 2024

Project Title

Dissect the molecular mechanism of ZFP36L2-mediated cell fate plasticity

Grant Number:

3R37CA266185-03S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2022

End Date:

1/31/2025

Project Abstract

PROJECT SUMMARY (unchanged from Parent R37) Metastasis causes >90% of cancer death. The persistence and lethality of metastasis is driven by cells capable of self-renewal, slow cell-cycling, tumor re-initiation, and therapy resistance, termed metastasis stem cells (MetSCs). Development of effective ...

Research Terms

<3' Untranslated Regions><3'UTR><Adherens Junction><Adhering Junction><Adhesive Junction><Advanced Cancer><Advanced Malignant Neoplasm><Anchoring Junction><Autoregulation><BFU-E><BFU-E - Burst-form unit eryth><BFU-E - Burst-forming unit erythroid><Binding><Body Tissues><CALL protein><Cadherin-1><CamL1 Gene Product><Cancer Genes><Cancer-Promoting Gene><Cancers><Cell Body><Cell Cycle><Cell Division Cycle><Cell Surface Glycoprotein L1><Cells><Cessation of life><Chromatin><Clinical><Colitis><Colorectal Cancer><Death><Development><E-Cadherin><EGF-Response Factor 2><ERF2><Elements><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Epithelial Calcium-Dependent Adhesion Protein><Epithelial-Cadherin><Epithelium><Erythroid Burst-Forming Units><F11 Glycoprotein><Family><Gene Transcription><Genes><Genetic Transcription><HG38><Homeostasis><Impairment><Intestinal><Intestinal Neoplasia><Intestinal Neoplasms><Intestinal Tumor><Intestines><Intestines Neoplasms><L1 Cell Adhesion Molecule><L1CAM><LGR5><LGR5 gene><Lymphatic cell><Lymphocyte><Lymphocytic><Maintenance><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mediating><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Molecular><Molecular Interaction><Mouse Homolog of TIS11D><Muscle><Muscle Tissue><NGF-Inducible Glycoprotein><NILE Glycoprotein><NILE Protein><Natural regeneration><Neoplasm Metastasis><Nerve Cells><Nerve Growth Factor-Inducible Large External Glycoprotein><Nerve Unit><Neural Adhesion Molecule L1><Neural Cell><Neural Cell Adhesion Molecule L1><Neurocyte><Neurons><Oncogenes><Organoids><Outcome><Parents><Patients><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Progenitor Cells><Proliferating><RNA Expression><RNA-Binding Proteins><Regeneration><Regulation><Resistance><Sampling><Secondary Neoplasm><Secondary Tumor><Stem Cell like><Stress><Structure><TIS11D><Tissues><Transcription><Transforming Genes><Uvomorulin><Wound Repair><ZFP36-Like 2><ZFP36L2><ZFP36L2 gene><Zinc Finger Protein 36-Like 2><bowel><cancer cell><cancer metastasis><cancer progenitor><cancer progenitor cells><cancer progression><cancer stem cell><derepression><developmental><epigenetically><epithelial progenitor><epithelial progenitor cell><epithelial stem cell><insight><intestinal epithelium><lymph cell><mRNA Degradation><mRNA Transcript Degradation><malignancy><malignant progenitor><malignant stem cell><member><muscular><neoplasm progression><neoplasm/cancer><neoplastic><neoplastic progression><neuronal><parent><progenitor><progenitor cell regeneration><progenitor cell self renewal><progenitor regeneration><progenitor self renewal><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regenerative><regenerative cell><repair><repaired><resistant><response><restoration><self-renew><self-renewal><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem cell characteristics><stem cell regeneration><stem cell self renewal><stem cells><stemness><therapeutic target><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptional reprogramming><tumor><tumor cell metastasis><tumor initiation><tumor progression><wound healing><wound recovery><wound resolution>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Erin A McClure

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Exploratory lead · 0/100
$75,500
FY 2022

Project Title

Determining the impact of cannabis use and severity on tobacco cessation outcomes: A prospective tobacco treatment trial

Grant Number:

3R37CA237245-04S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2019

End Date:

6/30/2024

Project Abstract

Project Summary/Abstract This application is being submitted in response to the Notice of Special Interest (NOSI) identified as NOT- CA-22-070: Administrative Supplements for Examining Patterns of Tobacco and Cannabis Use. This supplement request will support additional data collection as part of t...

Research Terms

<21+ years old><Abstinence><Active Follow-up><Address><Administrative Supplement><Adult><Adult Human><Adverse effects><Affect><Age><Area><Award><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biochemical><Cannabis><Conditioning Therapy><Counseling><Data><Data Collection><Dose><Drug Therapy><Drugs><Ecological momentary assessment><Enrollment><Event><Follow-Up Studies><Followup Studies><Funding><Future><General Population><General Public><Goals><Health><Individual><Individual Differences><Lead><Legislation><Literature><Measures><Medical><Medication><Methodology><Methods><Nicotine Dependence><Outcome><Parents><Participant><Patient Self-Report><Pattern><Pb element><Perception><Pharmaceutic Preparations><Pharmaceutical Preparations><Pharmacotherapy><Phase><Position><Positioning Attribute><Premedication><Prevalence><Prospective Studies><Recommendation><Research><Sampling Studies><Self-Report><Severities><Smoker><Statutes and Laws><Substance Use Disorder><THC co-use><THC use><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Time><Tobacco><Tobacco Cessation><Tobacco Consumption><Tobacco Use Cessation><Tobacco Use Disorder><Tobacco use><Treatment outcome><United States><Variant><Variation><Visit><Work><active followup><adulthood><ages><behavior intervention><behavioral intervention><cannabis cessation><cannabis use><cannabis user><cease smoking><clinical care><compare treatment><contingency management><develop therapy><diaries><drug treatment><drug/agent><efficacious therapy><efficacious treatment><enroll><follow up><follow-up><followed up><followup><heavy metal Pb><heavy metal lead><improved><interest><intervention development><marijuana use><marijuana user><nicotine addiction><nicotine dependent><prospective><psychosocial><quit smoking><recruit><response><smoking cessation><stop smoking><substance use><substance using><therapy development><tobacco abstinence><tobacco cessation intervention><tobacco cessation treatment><tobacco product use><tobacco user><treatment comparison><treatment development><treatment trial><varenicline>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kenneth R. Pugh

UNIVERSITY OF CONNECTICUT STORRS, STORRS-MANSFIELD, CT

Exploratory lead · 0/100
$64,384
FY 2024

Project Title

Tracking neurocognitive changes during evidence-based reading instruction in typically and atypically developing children

Grant Number:

3R37HD090153-08S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/6/2022

End Date:

8/31/2025

Project Abstract

Project Summary Research goals for the R37 extension (Year 6-10): We maintain the overarching goal of understanding variation in response to reading remediation in reading disabled (RD) learners with dynamic brain/behavior tracking designed to yield novel insights into how remediation modifies brain...

Research Terms

<0-11 years old><After Care><After-Treatment><Aftercare><Age><Behavior><Brain><Brain Nervous System><Brain imaging><Child><Child Youth><Children (0-21)><Children with Disabilities><Code><Coding System><Cognitive><Dependence><Development><Dimensions><Disabled Children><EEG><Educational Technology><Electroencephalogram><Electroencephalography><Employment><Encephalon><Evidence based treatment><Exhibits><Follow-Up Studies><Followup Studies><Functional MRI><Functional Magnetic Resonance Imaging><Funding><Goals><Grant><Handicapped Children><Image><Instruction><Language Development><Learning><Measures><Modeling><Neurobiology><Neurocognitive><Outcome><Phase><Reading><Research><Research Project Summaries><Sampling><Schools><Technology><Testing><Time><Training><Variant><Variation><acquiring language skills><adaptive learning><ages><base><bases><behavior change><brain based><brain visualization><cohort><coping><design><designing><developmental><disabled><elementary school><evidence base><experiment><experimental research><experimental study><experiments><fMRI><fNIRS><functional near infrared spectroscopy><grade school><imaging><insight><junior high><junior high school><kids><language acquisition><language learning><literacy><middle school><neural><neural imaging><neural model><neuro-imaging><neurobiological><neuroimaging><neurological imaging><novel><post treatment><recruit><remediation><response><response to therapy><response to treatment><therapeutic response><therapy response><treatment program><treatment response><treatment responsiveness><youngster>
View Full Project Details on NIH Reporter
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SUSAN J. FISHER

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 0/100
$25,056
FY 2021

Project Title

Dissecting gene dysregulation at the maternal-fetal interface in preeclampsia

Grant Number:

3R37HD076253-09S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2018

End Date:

6/30/2023

Project Abstract

Abstract. The goal of the proposed research is for Dr. Alejandra Elder Ontiveros to obtain additional training in reproductive biology at the postdoctoral level. She received her MD degree from Escuela de Medicina Ignacio A. Santos, Instituto Tecnologico y de Estudios Superiores de Monterrey. Under ...

Research Terms

<Affect><Award><Bio-Informatics><Bioinformatics><Biology><California><Cancer Biology><Cannot achieve a pregnancy><Career Mobility><Cell Body><Cell Differentiation><Cell Differentiation process><Cells><Cells Placenta-Tissue><Communication><Data><Data Analyses><Data Analysis><Data Set><Dataset><Development><Development and Research><Difficulty conceiving><Dimensions><Disease><Disorder><EPH Gestosis><Elderly><Ensure><Faculty><Formulation><Funding><Future><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Genes><Goals><Grant><Human><Infertility><Institution><Laboratories><Learning><Location><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Maternal-Fetal Exchange><Medical Research><Medicine><Mentors><Mentorship><Messenger RNA><Mice><Mice Mammals><Modern Man><Murine><Mus><Normal Placentoma><Patients><Physicians><Placenta><Placenta Biology><Placenta Embryonic Tissue><Placental Biology><Placental Development><Placentation><Placentome><Play><Pre-Eclampsia><Preeclampsia><Pregnancy Toxemias><Principal Investigator><Proteins><Proteinuria-Edema-Hypertension Gestosis><Proteome><R & D><R&D><Records><Reproductive Biology><Research><Role><San Francisco><Scientist><Syndrome><Technology><Testing><Training><Training Programs><Transcript Expression Analyses><Transcript Expression Analysis><Translating><Transplacental Exposure><Universities><Uterus><Woman><Work><Writing><advanced age><cancer immunology><career><career advancement><career development><career transition><college><collegiate><cytotrophoblast><data interpretation><design><designing><developmental><differential expression><differentially expressed><elders><endometriosis><experience><experiment><experimental research><experimental study><fertility cessation><fertility loss><full professor><gene expression analysis><gene expression assay><geriatric><global gene expression><global transcription profile><graduate student><infertile><instrumentation><late life><later life><mRNA><maternal-fetal interface><meetings><member><neoplasm immunology><novel><older adult><older person><outreach><pregnancy toxemia/hypertension><research and development><responsible research conduct><senior citizen><senior faculty><single cell sequencing><skills><social role><statistics><success><transcriptional differences><transcriptional profiling><transcriptome><tumor immunology><womb>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

VICTOR W HSU

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 0/100
$19,784
FY 2023

Project Title

Mechanisms and Physiology of COPI Transport

Grant Number:

3R37GM058615-21S1

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2001

End Date:

11/30/2025

Project Abstract

SUMMARY We are requesting an administrative supplement to the parent grant (R37 GM058615) to fund a CO2 incubator, specifically the Thermo Scientific Forma Steri-Cult CO2 Incubator Model 3310. Our current incubator just broke. It cannot be repaired, because it is too old and thus parts are no longer...

Research Terms

<Administrative Supplement><CO2><COP-1><COP-I><COPI><COPI Protein><Carbon Dioxide><Carbonic Anhydride><Cell Body><Cells><Coat Protein Complex I><Cultured Cells><Funding><Incubators><Modeling><Physiology><Productivity><Publications><Scientific Publication><Work><cost efficient><parent grant><repair><repaired>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Search NIH grants by PI name

Looking for a specific principal investigator? The keyword search above looks up funded projects by topic. To search NIH grants by PI name (last name, first + last name, or partial name) and see every active and recent NIH award for that researcher, use the dedicated PI Funding Status tool.

How to Use PI Funding Data for Career Decisions

Finding the right principal investigator is one of the most important decisions in an academic career. Whether you are a postdoc looking for a mentor, a graduate student choosing a rotation lab, or a collaborator seeking a co-PI, NIH funding data provides objective signals about which investigators have active research programs and resources to support new team members.

A PI with a recently awarded R01 or equivalent grant is more likely to have budget for new personnel than one whose funding ended two years ago. The activity code tells you the type of grant: R01 and R35 awards typically support multiple lab members, while K-series awards are individual career development grants that may not fund additional positions. Understanding these distinctions helps you interpret search results accurately.

Look beyond the dollar amount. A $500,000 per year R01 at a high-cost institution may support fewer positions than a $300,000 award at a university with lower overhead rates. The project abstract and public health relevance statement reveal whether the PI's research direction aligns with your interests and expertise.

Understanding PI Grant Portfolios

A PI's grant portfolio reveals more than individual awards. Investigators with multiple active grants often run larger labs with more diverse projects, which can mean more opportunities for trainees. However, a PI with a single well-funded grant may offer more focused mentorship and a clearer path to publications.

Multi-PI grants (those with more than one principal investigator listed) indicate collaborative research and may involve trainees from multiple institutions. These can be excellent opportunities for interdisciplinary training but may also mean split attention from any single mentor.

Pay attention to the timing of awards. A PI who just received a new five-year R01 is in a different position than one whose grant ends next year. New awards often correspond to lab expansion and active recruiting, making them ideal targets for job seekers. The start and end dates shown in each result help you assess this timing.

Best Practices for Contacting Funded PIs

Once you identify a promising PI through this tool, the next step is outreach. NIH public records do not include email addresses, but you can usually find contact information through the PI's institutional profile page, lab website, or recent publications. Google Scholar, PubMed, and the PI's department website are reliable starting points.

When reaching out, reference the specific grant that caught your attention. Mentioning the project title and explaining how your skills relate to the funded work shows that you have done your homework. Keep your initial message concise: introduce yourself, explain your interest, attach your CV, and ask whether they anticipate openings.

Timing matters. Contacting a PI within the first year of a new award is ideal, as this is when they are most likely to be recruiting. If you find multiple promising PIs in the same field, prioritize those with the most recent award notices and activity codes that support trainee positions such as R01, U01, or P-series grants.

Frequently Asked Questions About PI Search

What does the opportunity score mean?

The opportunity score is a heuristic that combines award recency, funding amount, activity code type, and project characteristics to estimate how actionable a result might be for job seekers or collaborators. Higher scores suggest stronger signals, but always verify by reading the abstract and checking the PI's current lab page.

Why can't I find a PI I know has funding?

Name variations are the most common cause. Try searching with just the last name, or use different formats like "Smith, John" versus "John Smith." Some PIs also publish under different name variations or may have awards under a previous institutional affiliation.

Does this tool show all NIH-funded PIs?

The tool searches NIH RePORTER data for the keyword and year range you specify. It returns PIs whose funded projects match your search terms. PIs with grants in unrelated areas or whose projects use different terminology will not appear in keyword-filtered results.

What is the difference between "Likely hiring" and "Training-friendly" filters?

"Likely hiring" flags PIs with large new awards or activity codes typically associated with lab expansion. "Training-friendly" identifies awards that include training components or are at institutions known for postdoctoral programs. Both are heuristic filters to help prioritize your outreach.

How to use this well

Start broad, then narrow. Search a field first, then refine by timeframe once you understand who is currently active.

After you find a promising PI, cross-check them in Check PI Funding and review their institution, mechanism type, and project abstracts before reaching out.

What a match means

A result means the keyword appears relevant to the funded project data we searched. It does not guarantee the PI is hiring or that the grant is still active.

Use the abstract, award year, mechanism, and organization context to decide whether the record is strategically relevant.

Data limits

NIH records can lag, institutional names can vary, and some investigators publish or file awards under multiple name formats.

For details on source coverage and refresh cadence, read Data & Methodology.

Related guides

Companion guides for turning a PI search result into useful outreach or a job lead.

Career Guide8 min read

How Postdocs Can Find PIs with New NIH Funding

A tactical job-search guide for identifying recently funded labs, judging fit, and timing outreach to principal investigators.

Read guide
Career Guide7 min read

How to Contact a PI: Finding Emails and Crafting the Perfect Message

Emailing strategies, outreach examples, and a workflow for turning NIH funding signals into focused PI conversations.

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Career Guide10 min read

How to Read a New NIH Award Like a Hiring Signal

A practical framework for using newly funded NIH awards to judge whether a lab may be expanding, hiring, or worth contacting now.

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Funding Strategy16 min read

How to Find NIH Funding Opportunities: A Step-by-Step Guide for Researchers

Learn how to find NIH funding opportunities using the NIH Guide, Grants.gov, FOAs, NIH RePORTER, and program officer outreach.

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Recently Funded Labs in Trending Areas

Principal investigators who received NIH awards in the last 90 days, organized by research area. Use this as a starting point for postdoc searches, collaborator outreach, or competitor scans. Counts and labs refresh daily.

Alzheimer's disease

Neurodegeneration, biomarkers, and disease-modifying therapies.

  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $101,153 · awarded Feb 25, 2026 · 3U01AG084514-01A1S1
  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $3,086,339 · awarded Feb 19, 2026 · 1U01AG084514-01A1
  • HARALD SONTHEIMER — UNIVERSITY OF VIRGINIA, VA
    Extracellular matrix and memory impairments in Alzheimer disease
    $709,066 · awarded Apr 7, 2026 · 5R01AG085359-03
  • Keith Josephs — MAYO CLINIC ROCHESTER, MN
    The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies
    $643,670 · awarded Apr 1, 2026 · 5R01DC014942-09
  • DMITRIY YABLONSKIY — WASHINGTON UNIVERSITY, MO
    Deep-Learning-Augmented Quantitative Gradient Recalled Echo (DLA-qGRE) MRI for in vivo Clinical Evaluation of Brain Microstructural Neurodegeneration in Alzheimer Disease
    $661,985 · awarded Mar 3, 2026 · 4R01AG082030-02
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CRISPR & gene editing

Therapeutic gene editing, base editing, and prime editing.

  • Changchun Liu — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT
    Asymmetric CRISPR Approach for Nucleic Acid Quantification
    $643,849 · awarded Mar 30, 2026 · 2R01EB023607-06A1
  • William Pu — BOSTON CHILDREN'S HOSPITAL, MA
    A modular system for murine CRISPR genome and epigenome editing
    $267,000 · awarded Mar 27, 2026 · 5R21OD037909-02
  • Naama Aviram — SLOAN-KETTERING INST CAN RESEARCH, NY
    Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systems
    $249,000 · awarded Apr 2, 2026 · 5R00GM148720-04
  • Mats Ljungman — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Precision targeting of bladder cancer using CRISPR
    $582,849 · awarded Feb 17, 2026 · 5R01CA285730-03
  • Shannon Miller — SCRIPPS RESEARCH INSTITUTE, THE, CA
    Development of potent and safe CRISPR tools for in vivo gene editing using directed evolution
    $230,000 · awarded May 5, 2026 · 5R21EB036298-03
Search more PIs in CRISPR & gene editing →

Cancer immunotherapy

Checkpoint inhibitors, CAR-T, TIL therapy, and beyond.

  • TERRY SHEPPARD — KEYSTONE SYMPOSIA, CO
    Cancer Immunotherapy: Basic Mechanisms Informing Clinical Applications & Combinations
    $5,000 · awarded Mar 3, 2026 · 1R13CA310704-01
  • Veronika Fedirko — UNIVERSITY OF TX MD ANDERSON CAN CTR, TX
    Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma
    $927,329 · awarded Mar 3, 2026 · 5R01CA255322-05
  • Yuwen Zhu — UNIVERSITY OF COLORADO DENVER, CO
    The GPR171 pathway in cancer immunotherapy
    $355,706 · awarded Apr 2, 2026 · 5R01CA279398-04
  • ANDREW WIEMER — UNIVERSITY OF CONNECTICUT STORRS, CT
    Synthesis and evaluation of BTN3A1 ligands for cancer immunotherapy
    $374,171 · awarded May 1, 2026 · 5R01CA266138-05
  • Wei Hu — YALE UNIVERSITY, CT
    Novel Treg inactivating approach for cancer immunotherapy via targeted protein degradation
    $482,312 · awarded Apr 6, 2026 · 1R01CA295942-01A1
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GLP-1 & metabolic disease

Diabetes, obesity, and weight-loss therapeutic mechanisms.

  • ZHIPING PANG — RUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ
    Synaptic and circuit mechanisms of central GLP-1 signaling in energy balance
    $479,051 · awarded Apr 23, 2026 · 5R01DK131452-05
  • Madhusmita Misra — UNIVERSITY OF VIRGINIA, VA
    Bone metabolism in adolescents undergoing GLP-1 receptor agonist therapy
    $471,776 · awarded Apr 24, 2026 · 5R01HD118635-07
  • STEVEN SCHWENDEMAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Remote Loading of Melanocortin and GLP-1 Peptides in Polymers for Treatment of Obesity
    $231,000 · awarded Apr 17, 2026 · 1R56DK141545-01A1
  • Jessica Barson — DREXEL UNIVERSITY, PA
    Suppression of ethanol dependence-induced maladaptive appetitive and consummatory behavior by the GLP-1 system
    $564,306 · awarded May 5, 2026 · 1R01AA031732-01A1
  • MICHAEL CAMILLERI — MAYO CLINIC ROCHESTER, MN
    A Randomized, placebo-controlled trial of the effects of Long-Acting GLP-1 or Dual Incretin (GLP-1 and GIP) Modulation on Gastrointestinal Functions and Relationship to Weight Loss
    $322,800 · awarded Apr 9, 2026 · 5R01DK142606-02
Search more PIs in GLP-1 & metabolic disease →

Long COVID

Post-acute sequelae and chronic infection-driven illness.

  • Alexei Tumanov — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX
    Lymphotoxin-dependent control of long COVID
    $234,715 · awarded Feb 13, 2026 · 1R21AI185790-01A1
  • Amal Amer — OHIO STATE UNIVERSITY, OH
    Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
    $2,974,582 · awarded Apr 21, 2026 · 5P01AI175399-03
  • Alba Azola — JOHNS HOPKINS UNIVERSITY, MD
    Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 onset ME/CFS versus Pre-Pandemic ME/CFS Patients
    $633,378 · awarded Apr 17, 2026 · 1R01NS147100-01
  • DANIELLE REED — MONELL CHEMICAL SENSES CENTER, PA
    Inflammation and chemosensory loss
    $2,654,249 · awarded Feb 26, 2026 · 1P50DC022549-01A1
  • Jarred Younger — UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL
    Low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
    $556,686 · awarded Mar 6, 2026 · 1UG3NS141843-01A1
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