NIH Grant Search by PI — Funded Principal Investigator Finder

Search NIH grants by PI name or research area. Look up funded principal investigators, see their NIH RePORTER awards, institutions, and project details.

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Enter a research topic, disease, or technology to find principal investigators with NIH funding in that area. To look up a specific PI by name, use the PI Funding Status check.

Search Results

Found 272 principal investigators from 200 displayed projects for "R21" (2021–2026)

Note: 4,130 projects matched but only the first 200 were analyzed. Try narrowing your search with a more specific term or selecting "Project title only".

Opportunity Digest

Heuristic scoring to help trainees and job seekers prioritize which labs to inspect first.

19

High-opportunity leads

69

Likely hiring signals

5

Training-friendly awards

35

Average opportunity score

Prioritize records with strong opportunity signals, then validate fit using abstracts, institution pages, and lab websites.

Filter for opportunity type

Xingjun Fan

AUGUSTA UNIVERSITY, AUGUSTA, GA

High-opportunity lead · 82/100
Likely hiring
Above-average budget
Very recent
Active award
$615,995
FY 2026

Project Title

Center Core Grant for Vision Research

Grant Number:

2P30EY031631-06

Activity Code:

P30

Mechanism:

Research Centers

Agency:

NIH

Start Date:

9/1/2020

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary (Overall) This renewal application seeks continuing P30 funding for another five years to support the vision science research at the James and Jean Culver Vision Discovery Institute (VDI), Medical College of Georgia (MCG) of Augusta University (AU). Vision scientists at VDI engage in...

Research Terms

<Advanced Instrumentation><Animal Model><Animal Models and Related Studies><Award><Bioinformatics><Biometrics><Biometry><Biostatistics><Blindness><Body Tissues><Cell Body><Cells><Center Core Grants><Clinical><Collaborations><Common Rat Strains><Communities><Computer Instrumentation><Computers and Advanced Instrumentation><Core Grant><Data><Data Analyses><Data Analysis><Data Collection><Development><Doctor of Philosophy><Eligibility><Eligibility Determination><Ensure><Equipment><Experimental Therapies><Eye><Eyeball><Faculty><Faculty Recruitment><Funding><Grant><Histology><Human Resources><Image><Institution><International><Investigational Therapies><Investigational Treatments><Investigators><Laboratories><Manpower><Mice><Mice Mammals><Mission><Murine><Mus><Names><P30 Award><P30 Grant><P30 Mechanism><P30 Program><Patients><Ph.D.><PhD><Pilot Projects><Productivity><Protocol Screening><Qualifying><R-Series Research Projects><R01 Mechanism><R01 Program><Rat><Rats Mammals><Rattus><Research><Research Grants><Research Institute><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Scientist><Series><Services><Sight><Technology><Time><Tissues><Travel><Universities><Vision><Vision Disorders><Vision research><Visual Disorder><Work><clinical relevance><clinically relevant><collaborative approach><conference><convention><data interpretation><developmental><experience><experimental therapeutic agents><experimental therapeutics><imaging><innovative technologies><instrument><instrumentation><interest><investigator training><medical college><medical schools><member><model of animal><name><named><naming><next generation><novel><personnel><pilot study><programs><recruit><recruit teachers><school of medicine><service organization><success><summit><symposia><symposium><teacher recruitment><vision loss><vision science><visual function><visual loss><visual science>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Baljit Khakh

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

High-opportunity lead · 80/100
Likely hiring
Large award
Very recent
Active award
$1,000,412
FY 2026

Project Title

Fundamental astrocyte biology in intact neural circuits

Grant Number:

5R35NS111583-08

Activity Code:

R35

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2019

End Date:

4/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Large budget suggests more room for personnel or project growth.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

A central goal of neurobiology is to understand how the brain forms, stores, retrieves, modifies and encodes information, and to determine how these operations go awry in neurological and psychiatric diseases. The focus of this application is astrocytes, a type of glia. Long considered simply the br...

Research Terms

<21+ years old><Abscission><Acquired brain injury><Adult><Adult Human><Astrocytes><Astrocytus><Astroglia><Autoregulation><Award><Basal Ganglia><Basal Nuclei><Biology><Blood Vessels><Brain><Brain Diseases><Brain Disorders><Brain Injuries><Brain Nervous System><CNS Nervous System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Central Nervous System><Corpus Striatum><Corpus striatum structure><Data><Data Bases><Databases><Development><Disease><Disorder><Dysfunction><Encephalon><Encephalon Diseases><Environment><Evaluation><Excision><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Extirpation><Functional disorder><Glia><Glial Cells><Glues><Goals><Homeostasis><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Ions><Kolliker's reticulum><Laboratories><Maintenance><Mental disorders><Mental health disorders><Molecular><Nerve Cells><Nerve Transmitter Substances><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Transmission><Neuraxis><Neurobiology><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic Disorders><Neurological Disorders><Neurons><Neurosciences><Neurotransmitters><Non-neuronal cell><Nonneuronal cell><Physicians><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Process><Psychiatric Disease><Psychiatric Disorder><R21 Award><Regulation><Removal><Research><Research Resources><Resources><Role><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Striate Body><Striatum><Surgical Removal><Synapses><Synaptic><Synaptic Transmission><Testing><Therapeutic><Training><Withdrawal><Work><adulthood><astrocytic glia><biological signal transduction><brain damage><brain-injured><data base><developmental><excitotoxic><excitotoxicity><in vivo><insight><mental illness><nerve cement><neural><neural circuit><neural circuitry><neuro-vascular coupling><neurobiological><neurocircuitry><neurological disease><neuronal><neurovascular coupling><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><operation><operations><pathophysiology><programs><psychiatric illness><psychological disorder><resection><social role><striatal><synapse><synapse formation><synaptic circuit><synaptic circuitry><synaptogenesis><tool><vascular>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Heather Emma Kitzman

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$767,831
FY 2026

Project Title

Food As Medicine to Reduce CKD Burden in Health Disparity Populations (FAME to Reduce CKD)

Grant Number:

1R01DK143078-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/20/2026

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Chronic kidney disease (CKD) is a major public health challenge that plagues approximately 1 in 7 Americans, most of whom experience asymptomatic progressive CKD until the disease is at advanced stages, resulting in devastating complications, including kidney failure and d...

Research Terms

<18 year old><18 years of age><21+ years old><Adult><Adult Human><African American><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><Albumins><Alkalies><American><Assess implementation><BMI><BMI percentile><BMI z-score><Behavior><Behavioral><Blood Pressure><Body mass index><Brothers><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cessation of life><Characteristics><Cholesterol><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Communities><Community Health><Consumption><Creatinine><Data><Death><Diagnosis><Diastolic Pressure><Diastolic blood pressure><Diet><Dietary Intervention><Dietary intake><Dietary quality><Disease><Disease Management><Disease Outcome><Disease Progression><Disorder><Disorder Management><Drug Therapy><Education><Educational aspects><Food><Future><Glycohemoglobin A><Glycosylated hemoglobin A><Goals><Groups at risk><HDL><HDL Cholesterol><HDL Cholesterol Lipoproteins><HDL Lipoproteins><Hand><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Health Care><Health Promotion><Health system><Healthy Eating><Heart Vascular><Heavy Lipoproteins><Hemoglobin A(1)><High Density Lipoprotein Cholesterol><High Density Lipoproteins><Hispanic><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Hour><Implementation assessment><Impoverished><Individual><Instruction><Intervention><Kidney><Kidney Failure><Kidney Insufficiency><Kidney Urinary System><Knowledge><LDL Cholesterol><LDL Cholesterol Lipoproteins><Lipids><Lipoprotein (a)><Lipoprotein Lp(a)><Low Density Lipoprotein Cholesterol><Lp(a)><Maps><Measurement><Measures><Mediator><Medicine><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Nutrition><Nutrition Interventions><Nutritional Interventions><Outcome><Participant><Pathway interactions><People at risk><Persons><Persons at risk><Pharmacological Treatment><Pharmacotherapy><Philosophy><Play><Population><Populations at Risk><Poverty><Prevention><Public Health><Public Health Practice><Quetelet index><RE-AIM><Randomized><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Renal Failure><Renal Insufficiency><Renal function><Risk><Role><Salutogenesis><Sampling><Self Efficacy><Social support><Socio-economic status><Socioeconomic Status><Survey Instrument><Surveys><Testing><Translating><Urine><Work><adulthood><age 18><age 18 years><alpha-Lipoprotein Cholesterol><alpha-Lipoproteins><base><bases><beta-Lipoprotein Cholesterol><burden of disease><burden of illness><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><chronic kidney disease><circulatory system><clinical significance><clinically significant><cohort><community based organizations><community intervention><community level intervention><community organizations><community setting><community-based health><community-based intervention><compare intervention><comparison intervention><cooking><diet adherence><diet intervention><diet quality><dietary><dietary adherence><diets><disease burden><disease prevention><disorder prevention><drug intervention><drug treatment><eighteen year old><eighteen years of age><ethnic diversity><ethnically diverse><evaluate implementation><evaluation of implementation><experience><fruits and vegetables><hands><health disparity community><health disparity group><health disparity populations><hemoglobin A1c><high risk><high risk group><high risk individual><high risk people><high risk population><implementation evaluation><implementation outcomes><improved><innovate><innovation><innovative><kidney function><kidney preservation><lipoprotein cholesterol><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><member><meter><multi-ethnic><multi-site trial><multiethnic><multisite trial><pathway><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><promoting health><randomisation><randomization><randomly assigned><reach, efficacy, adoption, implementation, and maintenance><recruit><renal><research study><secondary end point><secondary endpoint><skills><social><social role><social support network><socio-economic><socio-economic position><socio-economically><socioeconomic position><socioeconomically><socioeconomics>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sarah Elizabeth Messiah

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$767,831
FY 2026

Project Title

Food As Medicine to Reduce CKD Burden in Health Disparity Populations (FAME to Reduce CKD)

Grant Number:

1R01DK143078-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/20/2026

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Chronic kidney disease (CKD) is a major public health challenge that plagues approximately 1 in 7 Americans, most of whom experience asymptomatic progressive CKD until the disease is at advanced stages, resulting in devastating complications, including kidney failure and d...

Research Terms

<18 year old><18 years of age><21+ years old><Adult><Adult Human><African American><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><Albumins><Alkalies><American><Assess implementation><BMI><BMI percentile><BMI z-score><Behavior><Behavioral><Blood Pressure><Body mass index><Brothers><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cessation of life><Characteristics><Cholesterol><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Communities><Community Health><Consumption><Creatinine><Data><Death><Diagnosis><Diastolic Pressure><Diastolic blood pressure><Diet><Dietary Intervention><Dietary intake><Dietary quality><Disease><Disease Management><Disease Outcome><Disease Progression><Disorder><Disorder Management><Drug Therapy><Education><Educational aspects><Food><Future><Glycohemoglobin A><Glycosylated hemoglobin A><Goals><Groups at risk><HDL><HDL Cholesterol><HDL Cholesterol Lipoproteins><HDL Lipoproteins><Hand><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Health Care><Health Promotion><Health system><Healthy Eating><Heart Vascular><Heavy Lipoproteins><Hemoglobin A(1)><High Density Lipoprotein Cholesterol><High Density Lipoproteins><Hispanic><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Hour><Implementation assessment><Impoverished><Individual><Instruction><Intervention><Kidney><Kidney Failure><Kidney Insufficiency><Kidney Urinary System><Knowledge><LDL Cholesterol><LDL Cholesterol Lipoproteins><Lipids><Lipoprotein (a)><Lipoprotein Lp(a)><Low Density Lipoprotein Cholesterol><Lp(a)><Maps><Measurement><Measures><Mediator><Medicine><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Nutrition><Nutrition Interventions><Nutritional Interventions><Outcome><Participant><Pathway interactions><People at risk><Persons><Persons at risk><Pharmacological Treatment><Pharmacotherapy><Philosophy><Play><Population><Populations at Risk><Poverty><Prevention><Public Health><Public Health Practice><Quetelet index><RE-AIM><Randomized><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Renal Failure><Renal Insufficiency><Renal function><Risk><Role><Salutogenesis><Sampling><Self Efficacy><Social support><Socio-economic status><Socioeconomic Status><Survey Instrument><Surveys><Testing><Translating><Urine><Work><adulthood><age 18><age 18 years><alpha-Lipoprotein Cholesterol><alpha-Lipoproteins><base><bases><beta-Lipoprotein Cholesterol><burden of disease><burden of illness><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><chronic kidney disease><circulatory system><clinical significance><clinically significant><cohort><community based organizations><community intervention><community level intervention><community organizations><community setting><community-based health><community-based intervention><compare intervention><comparison intervention><cooking><diet adherence><diet intervention><diet quality><dietary><dietary adherence><diets><disease burden><disease prevention><disorder prevention><drug intervention><drug treatment><eighteen year old><eighteen years of age><ethnic diversity><ethnically diverse><evaluate implementation><evaluation of implementation><experience><fruits and vegetables><hands><health disparity community><health disparity group><health disparity populations><hemoglobin A1c><high risk><high risk group><high risk individual><high risk people><high risk population><implementation evaluation><implementation outcomes><improved><innovate><innovation><innovative><kidney function><kidney preservation><lipoprotein cholesterol><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><member><meter><multi-ethnic><multi-site trial><multiethnic><multisite trial><pathway><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><promoting health><randomisation><randomization><randomly assigned><reach, efficacy, adoption, implementation, and maintenance><recruit><renal><research study><secondary end point><secondary endpoint><skills><social><social role><social support network><socio-economic><socio-economic position><socio-economically><socioeconomic position><socioeconomically><socioeconomics>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

DONALD E WESSON

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$767,831
FY 2026

Project Title

Food As Medicine to Reduce CKD Burden in Health Disparity Populations (FAME to Reduce CKD)

Grant Number:

1R01DK143078-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/20/2026

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Chronic kidney disease (CKD) is a major public health challenge that plagues approximately 1 in 7 Americans, most of whom experience asymptomatic progressive CKD until the disease is at advanced stages, resulting in devastating complications, including kidney failure and d...

Research Terms

<18 year old><18 years of age><21+ years old><Adult><Adult Human><African American><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><Albumins><Alkalies><American><Assess implementation><BMI><BMI percentile><BMI z-score><Behavior><Behavioral><Blood Pressure><Body mass index><Brothers><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Cessation of life><Characteristics><Cholesterol><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Communities><Community Health><Consumption><Creatinine><Data><Death><Diagnosis><Diastolic Pressure><Diastolic blood pressure><Diet><Dietary Intervention><Dietary intake><Dietary quality><Disease><Disease Management><Disease Outcome><Disease Progression><Disorder><Disorder Management><Drug Therapy><Education><Educational aspects><Food><Future><Glycohemoglobin A><Glycosylated hemoglobin A><Goals><Groups at risk><HDL><HDL Cholesterol><HDL Cholesterol Lipoproteins><HDL Lipoproteins><Hand><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Health Care><Health Promotion><Health system><Healthy Eating><Heart Vascular><Heavy Lipoproteins><Hemoglobin A(1)><High Density Lipoprotein Cholesterol><High Density Lipoproteins><Hispanic><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Hour><Implementation assessment><Impoverished><Individual><Instruction><Intervention><Kidney><Kidney Failure><Kidney Insufficiency><Kidney Urinary System><Knowledge><LDL Cholesterol><LDL Cholesterol Lipoproteins><Lipids><Lipoprotein (a)><Lipoprotein Lp(a)><Low Density Lipoprotein Cholesterol><Lp(a)><Maps><Measurement><Measures><Mediator><Medicine><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Nutrition><Nutrition Interventions><Nutritional Interventions><Outcome><Participant><Pathway interactions><People at risk><Persons><Persons at risk><Pharmacological Treatment><Pharmacotherapy><Philosophy><Play><Population><Populations at Risk><Poverty><Prevention><Public Health><Public Health Practice><Quetelet index><RE-AIM><Randomized><Reach, Effectiveness, Adoption, Implementation, and Maintenance><Renal Failure><Renal Insufficiency><Renal function><Risk><Role><Salutogenesis><Sampling><Self Efficacy><Social support><Socio-economic status><Socioeconomic Status><Survey Instrument><Surveys><Testing><Translating><Urine><Work><adulthood><age 18><age 18 years><alpha-Lipoprotein Cholesterol><alpha-Lipoproteins><base><bases><beta-Lipoprotein Cholesterol><burden of disease><burden of illness><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><chronic kidney disease><circulatory system><clinical significance><clinically significant><cohort><community based organizations><community intervention><community level intervention><community organizations><community setting><community-based health><community-based intervention><compare intervention><comparison intervention><cooking><diet adherence><diet intervention><diet quality><dietary><dietary adherence><diets><disease burden><disease prevention><disorder prevention><drug intervention><drug treatment><eighteen year old><eighteen years of age><ethnic diversity><ethnically diverse><evaluate implementation><evaluation of implementation><experience><fruits and vegetables><hands><health disparity community><health disparity group><health disparity populations><hemoglobin A1c><high risk><high risk group><high risk individual><high risk people><high risk population><implementation evaluation><implementation outcomes><improved><innovate><innovation><innovative><kidney function><kidney preservation><lipoprotein cholesterol><low SES><low socio-economic position><low socio-economic status><low socioeconomic position><low socioeconomic status><member><meter><multi-ethnic><multi-site trial><multiethnic><multisite trial><pathway><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><promoting health><randomisation><randomization><randomly assigned><reach, efficacy, adoption, implementation, and maintenance><recruit><renal><research study><secondary end point><secondary endpoint><skills><social><social role><social support network><socio-economic><socio-economic position><socio-economically><socioeconomic position><socioeconomically><socioeconomics>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Monika Gulia-Nuss

UNIVERSITY OF NEVADA RENO, RENO, NV

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$652,336
FY 2026

Project Title

Germline Transformation of Ticks

Grant Number:

5R01AI172943-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/11/2023

End Date:

4/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Ticks and the pathogens they transmit incur significant costs to public health and agriculture worldwide. For instance, Ixodes scapularis, the primary vector of Lyme disease (LD) in the United States, is responsible for over 300,000 LD cases annually. The economic losses due to Rhip...

Research Terms

<Abscission><Agriculture><Anterior><Arthropod Vectors><Arthropoda><Arthropods><Biology><Black-legged Tick><Body Weight><Bovine Species><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cattle><Cell Body><Cell Growth in Number><Cell Line><Cell Multiplication><Cell Nucleus><Cell Proliferation><CellLine><Cells><Cellular Proliferation><Chimera Protein><Chimeric Proteins><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Complementary RNA><Culicidae><DNA><DNA Damage Repair><DNA Ligation><DNA Molecular Biology><DNA Repair><DNA mutation><Data><Deer Tick><Deoxyribonucleic Acid><Development><Disease><Disease Vectors><Disorder><Docking><Double Strand Break Repair><Drosophila><Drosophila genus><Economics><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Event><Excision><Exposure to><Extirpation><Frequencies><Fusion Protein><Future><Gametes><Gene Expression><Generations><Genes><Genetic><Genetic Change><Genetic Markers><Genetic Transformation><Genetic defect><Genetic mutation><Genome><Genome engineering><Germ><Germ Cells><Germ Lines><Germ-Line Cells><Germ-Line Mutation><Goals><Grant><Guide RNA><Hereditary Mutation><Heritability><I scapularis><I. scapularis><Incidence><Injections><Insecta><Insects><Insects Invertebrates><Ix scalpularis><Ix. scapularis><Ixodes dammini><Ixodes scapularis><Ixodida><Knock-in><Knock-out><Knockout><Knowledge><Location><Lyme Borreliosis><Lyme Disease><Mammalian Cell><Mediating><Methods><Modification><Molecular><Molecular Biology><Mosquitoes><Mutation><NHEJ><Non-Homologous End Joining><Non-homologous DNA End Joining><Nonhomologous DNA End Joining><Nonhomologous End Joining><Nucleotides><Nucleus><Organism><Outcome><Pathway interactions><Phenotype><Play><Population><Primordial Germ Cell><Protocol><Protocols documentation><Public Health><RNA interference screen><RNAi screen><RNAi-based screen><Removal><Reproductive Cells><Research><Scheme><Sex Cell><Site><Somatic Cell><Strains Cell Lines><Structure of primordial sex cell><Surgical Removal><System><Techniques><Testing><Tick Control><Tick-Borne Diseases><Ticks><Time><Transgenes><Transgenic Organisms><Transmission><Treatment Cost><United States><Unscheduled DNA Synthesis><Vertebrate Animals><Vertebrates><Work><blacklegged tick><bovid><bovine><controlling ticks><cost><cow><cultured cell line><developmental><disease control><disorder control><economic><egg><endonuclease><experiment><experimental research><experimental study><experiments><fruit fly><functional genomics><gRNA><gene biomarker><gene editing method><gene editing methodology><gene editing strategy><gene editing techniques><gene expression biomarker><gene function><gene marker><gene signature biomarker><gene-editing approach><genetic biomarker><genetic information><genome editing><genome mutation><genomic editing><germ-line defect><germline variant><improved><initial cell><interest><knockin><knockout gene><living system><migration><milk production><model organism><nano><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><new vaccines><next generation vaccines><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><novel vaccines><pathogen><pathway><precise genome editing><prevent><preventing><produce milk><promoter><promotor><repair><repaired><resection><scRNA sequencing><scRNA-seq><sexual cell><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><tick-borne illness><tickborne disease><tickborne illness><tool><transgene><transgenic><transmission process><vector><vertebrata>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

CHANDRAMOULI KRISHNAN

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$641,158
FY 2026

Project Title

Functional implications of stroke and Botulinum Neurotoxin on ankle stiffness and viscosity during gait

Grant Number:

5R01HD111567-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Gait impairments are ubiquitous after stroke, leading to persistent mobility deficits in most stroke survivors. Assessment of these impairments guides patient care and the use of clinical interventions, yet obtaining a complete picture of the factors that underlie these deficits rema...

Research Terms

<Abnormal gait><Address><Affect><Age><Ankle><Apoplexy><Articulatio talocruralis><BTX - based therapies><BTX injection><BTX treatment><Bilateral><Biomechanics><BoNT injection><BoNT therapy><BoNT treatment><Bontoxilysin><Botulin><Botulinum Toxins><Botulinum toxin type A injection><Brain Vascular Accident><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Clinic><Clinical><Clinical Treatment><Clostridium botulinum Toxins><Data><Drugs><Dysfunction><Equipment><Evaluation><Exhibits><Fostering><Foundations><Functional disorder><Funding><Gait><Gait abnormality><Gait disorder><Gait disturbances><Gait dysfunction><Gait impairment><Goals><Grant><Impairment><Individual><Injection of therapeutic agent><Injections><Intervention><Investigation><Joints><Knowledge><Leg><Locomotion><Manuals><Measurement><Measures><Mechanics><Medication><Motion><Movement><Muscle><Muscle Tissue><Nervous System Injuries><Nervous System Trauma><Nervous System damage><Neurological Damage><Neurological Injury><Neurological trauma><Orthosis><Orthotic Devices><Outcome><Patient Care><Patient Care Delivery><Patients><Persons><Pharmaceutical Preparations><Phase><Physiopathology><Process><Property><QOL><Qualifying><Quality of life><Regio tarsalis><Research><Resistance><Rest><Side><Social Interaction><Stroke><Symptoms><System><Techniques><Testing><Time><Torque><Viscosity><Visual><Walking><Walking impairment><Work><after stroke><ages><ankle joint><biomechanical><body movement><botox injection><botulinum neurotoxin><botulinum neurotoxin based therapeutic><botulinum neurotoxin injection><botulinum neurotoxin therapy><botulinum neurotoxin treatment><botulinum toxin injection><botulinum toxin therapy><botulinum toxin treatment><brain attack><care for patients><care of patients><caring for patients><cerebral vascular accident><cerebrovascular accident><clinical decision-making><clinical intervention><clinical therapy><drug/agent><experience><functional outcomes><improved><improved mobility><injected botulinum neurotoxin><injected with BoNT><injection therapy><innovate><innovation><innovative><insight><joint stiffness><mechanic><mechanical><mechanical properties><mobility enhancement><mobility improvement><muscular><neurotrauma><novel><optimized mobility><orthotics><pathophysiology><post stroke><poststroke><rehabilitation after stroke><resistant><response><spasticity><statistics><stem><stroke rehab><stroke rehabilitation><stroke survivor><stroke therapy><stroke treatment><stroked><strokes><tool><treating stroke><trial regimen><trial treatment>
View Full Project Details on NIH Reporter
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Elliott J Rouse

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$641,158
FY 2026

Project Title

Functional implications of stroke and Botulinum Neurotoxin on ankle stiffness and viscosity during gait

Grant Number:

5R01HD111567-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Gait impairments are ubiquitous after stroke, leading to persistent mobility deficits in most stroke survivors. Assessment of these impairments guides patient care and the use of clinical interventions, yet obtaining a complete picture of the factors that underlie these deficits rema...

Research Terms

<Abnormal gait><Address><Affect><Age><Ankle><Apoplexy><Articulatio talocruralis><BTX - based therapies><BTX injection><BTX treatment><Bilateral><Biomechanics><BoNT injection><BoNT therapy><BoNT treatment><Bontoxilysin><Botulin><Botulinum Toxins><Botulinum toxin type A injection><Brain Vascular Accident><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Clinic><Clinical><Clinical Treatment><Clostridium botulinum Toxins><Data><Drugs><Dysfunction><Equipment><Evaluation><Exhibits><Fostering><Foundations><Functional disorder><Funding><Gait><Gait abnormality><Gait disorder><Gait disturbances><Gait dysfunction><Gait impairment><Goals><Grant><Impairment><Individual><Injection of therapeutic agent><Injections><Intervention><Investigation><Joints><Knowledge><Leg><Locomotion><Manuals><Measurement><Measures><Mechanics><Medication><Motion><Movement><Muscle><Muscle Tissue><Nervous System Injuries><Nervous System Trauma><Nervous System damage><Neurological Damage><Neurological Injury><Neurological trauma><Orthosis><Orthotic Devices><Outcome><Patient Care><Patient Care Delivery><Patients><Persons><Pharmaceutical Preparations><Phase><Physiopathology><Process><Property><QOL><Qualifying><Quality of life><Regio tarsalis><Research><Resistance><Rest><Side><Social Interaction><Stroke><Symptoms><System><Techniques><Testing><Time><Torque><Viscosity><Visual><Walking><Walking impairment><Work><after stroke><ages><ankle joint><biomechanical><body movement><botox injection><botulinum neurotoxin><botulinum neurotoxin based therapeutic><botulinum neurotoxin injection><botulinum neurotoxin therapy><botulinum neurotoxin treatment><botulinum toxin injection><botulinum toxin therapy><botulinum toxin treatment><brain attack><care for patients><care of patients><caring for patients><cerebral vascular accident><cerebrovascular accident><clinical decision-making><clinical intervention><clinical therapy><drug/agent><experience><functional outcomes><improved><improved mobility><injected botulinum neurotoxin><injected with BoNT><injection therapy><innovate><innovation><innovative><insight><joint stiffness><mechanic><mechanical><mechanical properties><mobility enhancement><mobility improvement><muscular><neurotrauma><novel><optimized mobility><orthotics><pathophysiology><post stroke><poststroke><rehabilitation after stroke><resistant><response><spasticity><statistics><stem><stroke rehab><stroke rehabilitation><stroke survivor><stroke therapy><stroke treatment><stroked><strokes><tool><treating stroke><trial regimen><trial treatment>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

HAO LI

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$622,226
FY 2026

Project Title

Cellular and Tissue Rejuvenation through Transcriptional Reprogramming

Grant Number:

5R01AG083524-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

4/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary Organismal and cell rejuvenation are exciting new approaches to counteract aging, and recent breakthroughs have brought them to the forefront of aging research. For examples, systemic factors in young blood was found to rejuvenate various mouse tissues and brain function, and partial reprogr...

Research Terms

<Aging><Back><Basal Transcription Factor><Basal transcription factor genes><Behavioral Assay><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Body Tissues><Brain><Brain Nervous System><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Aging><Cell Body><Cell Culture Techniques><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Civilization><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Computational toolkit><Disease><Disorder><Dorsum><Dreams><Drugs><ENX-1><EZH1><EZH2><EZH2 gene><Encephalon><Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit><Environment><Fibroblasts><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Transcription><Grant><High Throughput Assay><Histology><Human><Human Figure><Human body><Imagination><In Vitro><Increase lifespan><Individual><KMT6><KMT6A><Liver><Medication><Methodology><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><NIH><National Institutes of Health><Organ><Personal Satisfaction><Pharmaceutical Preparations><Phenotype><Prevention><Progenitor Cells><RNA Expression><Rejuvenation><Replicative Senescence><Repression><Research><STAT3><STAT3 gene><Sampling><Testing><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transgenic Mice><United States National Institutes of Health><Youth><Youth 10-21><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age related pathways><age reversal><age-related disease><age-related disorder><age-related impairment><aged><aged mice><aged mouse><aging associated mechanism><aging mechanism><aging pathway><aging related mechanism><aging related pathways><aging reversal><alleviate age related><alleviate aging><ameliorating aging><analyze gene expression><artist><biological mechanism of age><biological pathways of age><boost longevity><cell age><cell culture><cell cultures><cellular age><chromatin modifier><combinatorial><comparative><computational toolbox><computational tools><computational toolset><computerized tools><counter age related><counter aging><counteract age related><counteract aging><disease model><disorder model><drug/agent><elderly mice><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><fiction><fictional works><foster longevity><gene expression analysis><gene expression assay><global gene expression><global transcription profile><hallmarks of aging><hepatic body system><hepatic organ system><high throughput screening><human tissue><improve lifespan><improve longevity><improved><in vivo><lifespan extension><mechanism regulating aging><mechanisms involved in aging><molecular phenotype><new approaches><new technology><novel approaches><novel strategies><novel strategy><novel technologies><old mice><overexpress><overexpression><pathway involved in aging><pillars of aging><programs><prolong lifespan><prolong longevity><promote lifespan><promote longevity><rejuvenating intervention><rejuvenation approach><rejuvenation strategies><rejuvenation therapy><rejuvenation treatment><replicative aging><reverse age><reverse aging><reverse aging effects><reversible aging><small molecule><stem cells><support longevity><technology intervention><technology-based interventions><technology-enabled interventions><technology-focused interventions><therapeutic rejuvenation><transcription factor><transcriptional profiling><transcriptional reprogramming><transcriptome><translation to humans><well-being><wellbeing><youth age>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

SAUL A VILLEDA

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$622,226
FY 2026

Project Title

Cellular and Tissue Rejuvenation through Transcriptional Reprogramming

Grant Number:

5R01AG083524-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2023

End Date:

4/30/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary Organismal and cell rejuvenation are exciting new approaches to counteract aging, and recent breakthroughs have brought them to the forefront of aging research. For examples, systemic factors in young blood was found to rejuvenate various mouse tissues and brain function, and partial reprogr...

Research Terms

<Aging><Back><Basal Transcription Factor><Basal transcription factor genes><Behavioral Assay><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Body Tissues><Brain><Brain Nervous System><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cell Aging><Cell Body><Cell Culture Techniques><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Chromatin Remodeling Complex><Chromatin Remodeling Factor><Civilization><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Computational toolkit><Disease><Disorder><Dorsum><Dreams><Drugs><ENX-1><EZH1><EZH2><EZH2 gene><Encephalon><Enhancer of Zeste 2 Polycomb Repressive Complex 2 Subunit><Environment><Fibroblasts><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Transcription><Grant><High Throughput Assay><Histology><Human><Human Figure><Human body><Imagination><In Vitro><Increase lifespan><Individual><KMT6><KMT6A><Liver><Medication><Methodology><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><NIH><National Institutes of Health><Organ><Personal Satisfaction><Pharmaceutical Preparations><Phenotype><Prevention><Progenitor Cells><RNA Expression><Rejuvenation><Replicative Senescence><Repression><Research><STAT3><STAT3 gene><Sampling><Testing><Tissues><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transgenic Mice><United States National Institutes of Health><Youth><Youth 10-21><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age related pathways><age reversal><age-related disease><age-related disorder><age-related impairment><aged><aged mice><aged mouse><aging associated mechanism><aging mechanism><aging pathway><aging related mechanism><aging related pathways><aging reversal><alleviate age related><alleviate aging><ameliorating aging><analyze gene expression><artist><biological mechanism of age><biological pathways of age><boost longevity><cell age><cell culture><cell cultures><cellular age><chromatin modifier><combinatorial><comparative><computational toolbox><computational tools><computational toolset><computerized tools><counter age related><counter aging><counteract age related><counteract aging><disease model><disorder model><drug/agent><elderly mice><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><fiction><fictional works><foster longevity><gene expression analysis><gene expression assay><global gene expression><global transcription profile><hallmarks of aging><hepatic body system><hepatic organ system><high throughput screening><human tissue><improve lifespan><improve longevity><improved><in vivo><lifespan extension><mechanism regulating aging><mechanisms involved in aging><molecular phenotype><new approaches><new technology><novel approaches><novel strategies><novel strategy><novel technologies><old mice><overexpress><overexpression><pathway involved in aging><pillars of aging><programs><prolong lifespan><prolong longevity><promote lifespan><promote longevity><rejuvenating intervention><rejuvenation approach><rejuvenation strategies><rejuvenation therapy><rejuvenation treatment><replicative aging><reverse age><reverse aging><reverse aging effects><reversible aging><small molecule><stem cells><support longevity><technology intervention><technology-based interventions><technology-enabled interventions><technology-focused interventions><therapeutic rejuvenation><transcription factor><transcriptional profiling><transcriptional reprogramming><transcriptome><translation to humans><well-being><wellbeing><youth age>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Pengpeng Bi

UNIVERSITY OF GEORGIA, ATHENS, GA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$614,390
FY 2026

Project Title

Molecular Mechanism of Human Myogenesis

Grant Number:

1R01AR087085-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Myoblast fusion is essential for muscle development and regeneration. The long-term goal of our research is to identify key molecular regulators of this process, focusing on the role of CHAMP1 gene in CHAMP1 syndrome—a severe developmental disorder characterized by muscle weakness, hypotonia, and mo...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Alleles><Allelomorphs><Animal Model><Animal Models and Related Studies><Antimorphic mutation><Assay><Bioassay><Biochemical><Biological Assay><Body Tissues><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas9 screen><Caring><Cell Body><Cell model><Cells><Cellular model><Chromosomal Deletion><Chromosome Deletion><Chromosomes><Collaborations><Complex><DNA Therapy><DNA mutation><Decreased Muscle Tone><Defect><Development><Disease><Disorder><Dominant Negative><Dominant-Negative Mutant><Dominant-Negative Mutation><E1A Binding Protein p300><EP300><EP300 gene><Embryo><Embryonic><Embryonic Muscle Cells><Event><Exhibits><Face><Family><Foundations><Functional impairment><Funding><Gene Expression><Gene Transfer Clinical><Genes><Genetic><Genetic Change><Genetic Intervention><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Goals><Heterozygote><Human><Human Chromosomes><Hypomyotonia><Hypotonia><Impairment><KAT3B><Lead><Letters><Locomotion><Maps><Mediating><Modern Man><Molecular><Molecular Target><Morphology><Muscle><Muscle Cell Contraction><Muscle Cells><Muscle Contraction><Muscle Development><Muscle Disease><Muscle Disorders><Muscle Hypotony><Muscle Tissue><Muscle Tone Poor><Muscle Weakness><Muscle function><Muscle hypotonia><Muscular Contraction><Muscular Development><Muscular Diseases><Muscular Hypotonia><Muscular Weakness><Mutagenesis><Mutagenesis Molecular Biology><Mutant Strains Mice><Mutation><Myoblasts><Myocytes><Myopathic Conditions><Myopathic Diseases and Syndromes><Myopathic disease or syndrome><Myopathy><Names><Neonatal><Outcome><Partial Monosomy><Patients><Pb element><Performance><Phenotype><Phosphoproteins><Precursor Muscle Cells><Process><Proliferating><Proteins><RNA Seq><RNA sequencing><RNAseq><Rationalization><Regulation><Research><Role><Science><Series><Structural Models><Structure><Symptoms><Syndrome><Testing><Tissues><Toxin><Transactivation><Transplantation><ZNFs><Zinc Finger Domain><Zinc Finger Motifs><Zinc Fingers><Zn-finger nuclease><adulthood><associated symptom><clustered regularly interspaced short palindromic repeats screen><co-morbid symptom><co-occuring symptom><cofactor><comorbid symptom><concurrent symptom><conference><convention><cooccuring symptom><developmental><developmental disease><developmental disorder><drug development><experiment><experimental research><experimental study><experiments><faces><facial><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genome mutation><genomic therapy><heavy metal Pb><heavy metal lead><heterozygosity><histone acetyltransferase p300><in vivo><insight><interest><mobility aid><mobility device><model of animal><motor impairment><mouse model><mouse mutant><movement impairment><movement limitation><murine model><muscle regeneration><muscular><muscular disorder><myogenesis><name><named><naming><novel><p300><patient advocacy group><postnatal><protein function><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><summit><symposia><symposium><symptom association><symptom comorbidity><tool><trans-activation><transcriptome sequencing><transcriptomic sequencing><transplant><transplant model><zinc finger nuclease><zinc finger nucleases>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Pushkar Prakash Lele

TEXAS ENGINEERING EXPERIMENT STATION, COLLEGE STATION, TX

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$605,277
FY 2026

Project Title

Rapid Stress Response in Bacterial Pathogens: the Role of Extant Porins in Antibiotic Tolerance

Grant Number:

5R01AI188941-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/28/2025

End Date:

4/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Cells of most Gram-negative bacterial pathogens can develop tolerance to chemical stressors through rapid adaptations in the outer membrane that are poorly understood. This application focuses on uncovering the adaptation mechanisms responsible for stress-induced tolerance to chemic...

Research Terms

<ATP Synthesis><ATP Synthesis Pathway><Anti-Bacterial Agents><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Assay><Bacteria><Benemycin><Bioassay><Biological Assay><Catalogs><Cause of Death><Cell Body><Cell Locomotion><Cell Migration><Cell Movement><Cell division><Cells><Cellular Expansion><Cellular Growth><Cellular Migration><Cellular Motility><Chemicals><Chemoattractants><Chemotactic Factors><Chemotaxins><Chemotaxis><Ciprofloxacin><Clinical><Colony-forming units><DNA Replication><DNA Synthesis><DNA biosynthesis><Data><Down-Regulation><Drug Transport><Drugs><E coli><E. coli><Escherichia coli><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Exposure to><Fluorescence><Fluorescence Agents><Fluorescent Agents><Fluorescent Dyes><Gene Transcription><Genetic Transcription><Goals><Gram-Negative Bacteria><Health><Heterogeneity><Human><Intake><Libraries><Ligands><Link><Long-term infection><Math><Math Models><Mathematics><Measurement><Measures><Mediating><Medication><Membrane><Membrane Transport><Meropenem><Miscellaneous Antibiotic><Modeling><Modern Man><Modification><Molecular><Motility><NIAID><National Institute of Allergy and Infectious Disease><Oxygen Consumption><Pathogenicity><Pathway interactions><Pharmaceutical Preparations><Phenotype><Physiologic><Physiological><Polyamine Compound><Polyamines><Population><Property><Proton-Motive Force><Public Health><R21 Award><RNA Expression><Recurrent disease><Relapsed Disease><Resistance to antibiotics><Resistant to antibiotics><Respiration><Rifadin><Rifampicin><Rifampin><Rimactane><Role><Stress><Subgroup><Techniques><Testing><Time><Transcription><Transmembrane Transport><VDAC1><VDAC1 gene><Vancomycin><Viscosity><Work><anti-bacterial><antibiotic drug resistance><antibiotic resistant><antibiotic tolerance><bacteria pathogen><bacterial pathogen><bactericidal><bactericide><biological adaptation to stress><biophysical approaches><biophysical methodology><biophysical methods><biophysical techniques><catalog><cell growth><cell motility><chronic infection><clinical relevance><clinically relevant><combat><complement chemotactic factor><drug/agent><experiment><experimental research><experimental study><experiments><extracellular><fluorescence imaging><fluorescent dye/probe><fluorescent imaging><infection recurrence><inhibitor><innovate><innovation><innovative><insight><mathematic model><mathematical model><mathematical modeling><membrane structure><multi-drug tolerance><multidrug tolerance><multiple drug tolerance><novel><pathogen><pathogenic bacteria><pathway><persistent infection><pore forming protein><porin><preservation><prevent><preventing><reactioncrisis><recurrent infection><recurring infection><respiratory mechanism><response><segregation><social role><stress response><stress tolerance><stressreaction><stressor><tolerance to antibiotics><tolerant to multiple drugs><tolerate antibiotics><uptake>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Angela Marie Mitchell

TEXAS ENGINEERING EXPERIMENT STATION, COLLEGE STATION, TX

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$605,277
FY 2026

Project Title

Rapid Stress Response in Bacterial Pathogens: the Role of Extant Porins in Antibiotic Tolerance

Grant Number:

5R01AI188941-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/28/2025

End Date:

4/30/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Cells of most Gram-negative bacterial pathogens can develop tolerance to chemical stressors through rapid adaptations in the outer membrane that are poorly understood. This application focuses on uncovering the adaptation mechanisms responsible for stress-induced tolerance to chemic...

Research Terms

<ATP Synthesis><ATP Synthesis Pathway><Anti-Bacterial Agents><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Assay><Bacteria><Benemycin><Bioassay><Biological Assay><Catalogs><Cause of Death><Cell Body><Cell Locomotion><Cell Migration><Cell Movement><Cell division><Cells><Cellular Expansion><Cellular Growth><Cellular Migration><Cellular Motility><Chemicals><Chemoattractants><Chemotactic Factors><Chemotaxins><Chemotaxis><Ciprofloxacin><Clinical><Colony-forming units><DNA Replication><DNA Synthesis><DNA biosynthesis><Data><Down-Regulation><Drug Transport><Drugs><E coli><E. coli><Escherichia coli><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Exposure to><Fluorescence><Fluorescence Agents><Fluorescent Agents><Fluorescent Dyes><Gene Transcription><Genetic Transcription><Goals><Gram-Negative Bacteria><Health><Heterogeneity><Human><Intake><Libraries><Ligands><Link><Long-term infection><Math><Math Models><Mathematics><Measurement><Measures><Mediating><Medication><Membrane><Membrane Transport><Meropenem><Miscellaneous Antibiotic><Modeling><Modern Man><Modification><Molecular><Motility><NIAID><National Institute of Allergy and Infectious Disease><Oxygen Consumption><Pathogenicity><Pathway interactions><Pharmaceutical Preparations><Phenotype><Physiologic><Physiological><Polyamine Compound><Polyamines><Population><Property><Proton-Motive Force><Public Health><R21 Award><RNA Expression><Recurrent disease><Relapsed Disease><Resistance to antibiotics><Resistant to antibiotics><Respiration><Rifadin><Rifampicin><Rifampin><Rimactane><Role><Stress><Subgroup><Techniques><Testing><Time><Transcription><Transmembrane Transport><VDAC1><VDAC1 gene><Vancomycin><Viscosity><Work><anti-bacterial><antibiotic drug resistance><antibiotic resistant><antibiotic tolerance><bacteria pathogen><bacterial pathogen><bactericidal><bactericide><biological adaptation to stress><biophysical approaches><biophysical methodology><biophysical methods><biophysical techniques><catalog><cell growth><cell motility><chronic infection><clinical relevance><clinically relevant><combat><complement chemotactic factor><drug/agent><experiment><experimental research><experimental study><experiments><extracellular><fluorescence imaging><fluorescent dye/probe><fluorescent imaging><infection recurrence><inhibitor><innovate><innovation><innovative><insight><mathematic model><mathematical model><mathematical modeling><membrane structure><multi-drug tolerance><multidrug tolerance><multiple drug tolerance><novel><pathogen><pathogenic bacteria><pathway><persistent infection><pore forming protein><porin><preservation><prevent><preventing><reactioncrisis><recurrent infection><recurring infection><respiratory mechanism><response><segregation><social role><stress response><stress tolerance><stressreaction><stressor><tolerance to antibiotics><tolerant to multiple drugs><tolerate antibiotics><uptake>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Mark Samuel Blumberg

UNIVERSITY OF IOWA, IOWA CITY, IA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$572,336
FY 2026

Project Title

Sleep-related behavior and cortical activity in premature human infants as predictors of developmental outcomes.

Grant Number:

5R01HD104616-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/5/2022

End Date:

4/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Sleep permeates our early existence: A typical human newborn sleeps 16 hours each day, evenly divided between active (REM) sleep and quiet sleep. The relatively high proportion of active sleep in newborns is the foundation for the decades-old hypothesis that active sleep is important...

Research Terms

<0-4 weeks old><2 year old><2 years of age><ASD><Age><Age Months><Ammon Horn><Attention><Autism><Autistic Disorder><Behavior><Behavioral><Brain><Brain Nervous System><Brain Stem><Brainstem><Cardiac Chronotropism><Cerebellum><Cerebral Palsy><Children's Hospital><Clinical><Cognitive><Common Rat Strains><Communities><Complex><Cornu Ammonis><Data><Data Set><Development><Dysfunction><EEG><Early Infantile Autism><Electroencephalogram><Electroencephalography><Encephalon><Exhibits><Extremities><Eye><Eyeball><Face><Family><Fetal Activity><Fetal Movement><Fetus><Foundations><Functional disorder><Funding><Future><Heart Rate><Hippocampus><Hour><Human><Infant><Infantile Autism><Intervention><Investigation><Iowa><Kanner's Syndrome><Life><Limb structure><Limbs><Link><Longitudinal Studies><Longitudinal Surveys><Mediating><Medulla Spinalis><Modern Man><Motor Skills><Muscle><Muscle Tissue><NICHD><National Institute of Child Health and Human Development><Neonatal Intensive Care Units><Neurodevelopmental Disorder><Neurological Development Disorder><Newborn Infant><Newborn Intensive Care Units><Newborns><Non-Trunk><Outcome><Pattern><Pediatric Hospitals><Phase><Physiologic><Physiological><Physiopathology><Play><Premature Birth><Premature Infant><Prematurely delivering><Preterm Birth><Rat><Rats Mammals><Rattus><Research><Respiration><Risk><Role><Scientist><Sensory><Sleep><Spinal Cord><Strategic Planning><Survival Rate><Term Birth><Testing><Thalamic structure><Thalamus><Time><Universities><age 2><age 2 years><aged 2 years><aged two years><ages><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior measurement><behavioral measure><behavioral measurement><biobehavior><biobehavioral><density><developmental><diagnostic tool><extreme prematurity><extremely premature infant><extremely preterm><extremely preterm infant><faces><facial><fetal><follow up assessment><followup assessment><full-term birth><full-term newborn><hippocampal><infants born premature><infants born prematurely><innovate><innovation><innovative><investigate longitudinal><lab development><laboratory development><limb movement><long-term study><longitudinal design><longitudinal experimental design><longitudinal investigation><longitudinal outcome studies><longitudinal research><longitudinal research design><longitudinal research study><longitudinal study design><member><motor ability><muscular><neonatal ICU><neural correlate><neurobehavioral><neurodevelopmental disease><newborn child><newborn children><pathophysiology><post-natal development><postnatal><postnatal development><premature baby><premature childbirth><premature delivery><premature infant human><preterm baby><preterm delivery><preterm infant><preterm infant human><rapid eye movement><recruit><respiratory><respiratory mechanism><sensorimotor system><sensory feedback><sensory input><sensory motor system><sleep amount><sleep behavior><sleep duration><sleep episode><sleep habit><sleep interval><sleep length><sleep period><sleep quantity><sleep time><sleep/wake behavior><social role><spatial and temporal><spatial temporal><spatiotemporal><study longitudinal><survey longitudinal><term newborn><thalamic><theories><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><two year old><two years of age><ultrasound><very premature><very preterm>
View Full Project Details on NIH Reporter
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Cecilia J Hillard

UNIVERSITY OF WISCONSIN MILWAUKEE, MILWAUKEE, WI

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$568,448
FY 2026

Project Title

Examining the longitudinal impact of circulating endocannabinoid levels on neurocognition, impulsivity, and early cannabis use patterns in youth enrolled in the ABCD Study

Grant Number:

5R01DA062432-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The endogenous endocannabinoid (eCB) system includes cannabinoid receptor 1 (CB1R), CB2R, and two endogenous ligands (N-arachidonoylethanolamine, AEA and 2-arachidonoylglycerol, 2AG) and endocannabinoid lipid mediators (oleoylethanolamide, OEA, palmitoylethanolamide, PEA, and 2-oleoy...

Research Terms

<12-20 years old><13 year old><13 years of age><2-AG><2-arachidonoyl-glycerol><2-arachidonoyl-sn-glycerol><2-arachidonoylglycerol><2-arachidonyl-glycerol><2-arachidonylglycerol><20 year old><20 years of age><21+ years old><Address><Adolescence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adult><Adult Human><Affective><Age><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Animals><Assay><Behavior><Behavioral><Bioassay><Biological Assay><Blood><Blood Reticuloendothelial System><Blood Serum><Brain><Brain Nervous System><Brain region><CB1><CB1 Receptor><CB1R><CB2><CB2 Receptor><CB2R><CNR1 gene><CNR2><CNR2 gene><Cannabinoid Receptor CB1><Cannabinoid Receptor CB2><Cannabis><Cell Communication and Signaling><Cell Signaling><Cognitive><Corpus Striatum><Corpus striatum structure><Data><Development><Differences between sexes><Differs between sexes><ECB signaling><Emotional><Encephalon><Endocannabinoids><Endogenous Cannabinoids><Enrollment><EtOH drinking><EtOH use><Female><Future><Generalized Growth><Growth><Human><Immediate Memory><Impulsivity><Intercept><Intracellular Communication and Signaling><Investigation><Knowledge><Ligands><Link><Lipids><Longitudinal Studies><Longitudinal Surveys><Measures><Modeling><Modern Man><N arachidonoyl 2 hydroxyethylamide><N-arachidonoylethanolamine><N-palmitoylethanolamine><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neural Development><Neurocognition><Neurocognitive><Neurocyte><Neuronal Transmission><Neurons><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Parietal><Peripheral><Personality><Pilot Projects><Play><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Process><Psychopathology><Rad.-PET><Research><Rewards><Risk><Role><Sampling><Scientist><Serum><Sex Differences><Sexual differences><Short-Term Memory><Signal Transduction><Signal Transduction Systems><Signaling><Site><Striate Body><Striatum><Structure><Symptoms><System><THC co-use><THC use><Techniques><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Thick><Thickness><Time><Tissue Growth><Youth><Youth 10-21><abnormal brain function><abnormal psychology><adolescence (12-20)><adult animal><adulthood><age 13><age 13 years><age 20><age 20 years><ages><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><anandamide><arachidonoyl ethanolamide><arachidonoylethanolamide><arachidonylethanolamide><axon signaling><axon-glial signaling><axonal signaling><behavior outcome><behavioral outcome><biological adaptation to stress><biological signal transduction><brain abnormalities><brain dysfunction><brain impairment><brain volume><cannabinoid receptor 1><cannabinoid receptor 2><cannabinoid receptor type 1><cannabinoid receptor type 2><cannabinoid type 1><cannabis use><cannabis use behavior><cannabis use patterns><cognitive control><cognitive development><cognitive function><cohort><density><developmental><dysfunctional brain><eCB system><early initiation substance use><early onset><early onset substance use><endocannabinoid signaling><endocannabinoid system><endogenous cannabinoid system><enroll><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><executive control><executive function><glia signaling><glial signaling><juvenile><juvenile human><lipid mediator><long-term study><longitudinal outcome studies><longitudinal research study><male><marijuana use><mature animal><nerve signaling><neural signaling><neurodevelopment><neuron development><neuronal><neuronal development><neuronal signaling><neurotransmission><novel><oleoylethanolamide><ontogeny><palmidrol><palmitoylethanolamide><palmitylethanolamide><pilot study><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><preclinical><reactioncrisis><response><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><stress response><stressreaction><striatal><substance use><substance using><substantia alba><thirteen year old><thirteen years of age><twenty year old><twenty years of age><white matter><working memory><youth age><♀><♂>
View Full Project Details on NIH Reporter
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Krista Maurine Lisdahl

UNIVERSITY OF WISCONSIN MILWAUKEE, MILWAUKEE, WI

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$568,448
FY 2026

Project Title

Examining the longitudinal impact of circulating endocannabinoid levels on neurocognition, impulsivity, and early cannabis use patterns in youth enrolled in the ABCD Study

Grant Number:

5R01DA062432-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY The endogenous endocannabinoid (eCB) system includes cannabinoid receptor 1 (CB1R), CB2R, and two endogenous ligands (N-arachidonoylethanolamine, AEA and 2-arachidonoylglycerol, 2AG) and endocannabinoid lipid mediators (oleoylethanolamide, OEA, palmitoylethanolamide, PEA, and 2-oleoy...

Research Terms

<12-20 years old><13 year old><13 years of age><2-AG><2-arachidonoyl-glycerol><2-arachidonoyl-sn-glycerol><2-arachidonoylglycerol><2-arachidonyl-glycerol><2-arachidonylglycerol><20 year old><20 years of age><21+ years old><Address><Adolescence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adult><Adult Human><Affective><Age><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Animals><Assay><Behavior><Behavioral><Bioassay><Biological Assay><Blood><Blood Reticuloendothelial System><Blood Serum><Brain><Brain Nervous System><Brain region><CB1><CB1 Receptor><CB1R><CB2><CB2 Receptor><CB2R><CNR1 gene><CNR2><CNR2 gene><Cannabinoid Receptor CB1><Cannabinoid Receptor CB2><Cannabis><Cell Communication and Signaling><Cell Signaling><Cognitive><Corpus Striatum><Corpus striatum structure><Data><Development><Differences between sexes><Differs between sexes><ECB signaling><Emotional><Encephalon><Endocannabinoids><Endogenous Cannabinoids><Enrollment><EtOH drinking><EtOH use><Female><Future><Generalized Growth><Growth><Human><Immediate Memory><Impulsivity><Intercept><Intracellular Communication and Signaling><Investigation><Knowledge><Ligands><Link><Lipids><Longitudinal Studies><Longitudinal Surveys><Measures><Modeling><Modern Man><N arachidonoyl 2 hydroxyethylamide><N-arachidonoylethanolamine><N-palmitoylethanolamine><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neural Development><Neurocognition><Neurocognitive><Neurocyte><Neuronal Transmission><Neurons><Outcome><PET><PET Scan><PET imaging><PETSCAN><PETT><Parietal><Peripheral><Personality><Pilot Projects><Play><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Process><Psychopathology><Rad.-PET><Research><Rewards><Risk><Role><Sampling><Scientist><Serum><Sex Differences><Sexual differences><Short-Term Memory><Signal Transduction><Signal Transduction Systems><Signaling><Site><Striate Body><Striatum><Structure><Symptoms><System><THC co-use><THC use><Techniques><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Thick><Thickness><Time><Tissue Growth><Youth><Youth 10-21><abnormal brain function><abnormal psychology><adolescence (12-20)><adult animal><adulthood><age 13><age 13 years><age 20><age 20 years><ages><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><anandamide><arachidonoyl ethanolamide><arachidonoylethanolamide><arachidonylethanolamide><axon signaling><axon-glial signaling><axonal signaling><behavior outcome><behavioral outcome><biological adaptation to stress><biological signal transduction><brain abnormalities><brain dysfunction><brain impairment><brain volume><cannabinoid receptor 1><cannabinoid receptor 2><cannabinoid receptor type 1><cannabinoid receptor type 2><cannabinoid type 1><cannabis use><cannabis use behavior><cannabis use patterns><cognitive control><cognitive development><cognitive function><cohort><density><developmental><dysfunctional brain><eCB system><early initiation substance use><early onset><early onset substance use><endocannabinoid signaling><endocannabinoid system><endogenous cannabinoid system><enroll><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><executive control><executive function><glia signaling><glial signaling><juvenile><juvenile human><lipid mediator><long-term study><longitudinal outcome studies><longitudinal research study><male><marijuana use><mature animal><nerve signaling><neural signaling><neurodevelopment><neuron development><neuronal><neuronal development><neuronal signaling><neurotransmission><novel><oleoylethanolamide><ontogeny><palmidrol><palmitoylethanolamide><palmitylethanolamide><pilot study><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical><preclinical><reactioncrisis><response><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><stress response><stressreaction><striatal><substance use><substance using><substantia alba><thirteen year old><thirteen years of age><twenty year old><twenty years of age><white matter><working memory><youth age><♀><♂>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Prasanna Jagannathan

STANFORD UNIVERSITY, STANFORD, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$563,176
FY 2026

Project Title

Perennial Malaria Chemoprevention in the Malaria Vaccine Era (PMC-VAC)

Grant Number:

1R01AI195195-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2033

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Malaria continues to result in 597,000 deaths annually, mainly due to Plasmodium Falciparum in young African children. An affordable malaria vaccine, R21, was recently approved by the World Health Organization (WHO) for infants beginning at 5-6 months of age and will soon be deployed in Uganda and o...

Research Terms

<0-11 years old><5 year old><5 years of age><Active Follow-up><Adverse Experience><Adverse event><Africa><African><Age><Age Months><Amodiaquin><Amodiaquine><Anti-malarials><Area><Artemisinins><Central Africa><Cessation of life><Chemoprevention><Child><Child Youth><Childhood><Children (0-21)><Clinical Trials><Combined Modality Therapy><Country><Daraprim><Death><Dose><Drug resistance><Drugs><Eastern Africa><Exposure to><Falciparum Malaria><Genetic Polymorphism><Immune response><Immunity><Immunization><Immunization Schedule><Incidence><Infant><Infection><Intervention><Life><Logistics><Long-Term Effects><Malaria><Malaria Vaccines><Malarial Vaccines><Medication><Memory><Morbidity><Multimodal Therapy><Multimodal Treatment><P falciparum><P. falciparum><P.falciparum><Paludism><Parasites><Pharmaceutical Preparations><Placebos><Plasmodium Infections><Plasmodium falciparum><Plasmodium falciparum Malaria><Prevalence><Pyrimethamine><Randomized><Recommendation><Regimen><Resistance><Safety><Schedule><Seasons><Series><Sham Treatment><Southern Africa><Study Subject><Sulfadoxine><Sulformethoxine><Sulformetoxine><Sulforthomidine><Sulphormetoxin><Testing><Time><Transmission><Uganda><Vaccination><Vaccines><Visit><World Health Organization><active followup><age 5><age 5 years><ages><anti-malarial agents><anti-malarial drugs><arm><arteannuin><artemisinine><booster dose><booster shot><booster vaccine><combination therapy><combined modality treatment><combined treatment><comparable efficacy><comparative efficacy><compare efficacy><deploy vaccines><distribute vaccines><drug resistant><drug/agent><five year old><five years of age><follow up><follow-up><followed up><followup><host response><immune response to vaccination><immune response to vaccines><immune system response><immunogenicity><immunoresponse><kids><malaria transmission><mortality><multi-modal therapy><multi-modal treatment><novel><pediatric><policy implication><polymorphism><primary end point><primary endpoint><programs><protective efficacy><qinghaosu><quing hau sau><quinghaosu><randomisation><randomization><randomly assigned><resistance to Drug><resistant><resistant to Drug><response><secondary end point><secondary endpoint><sham therapy><standard of care><transmission process><trial comparing><uptake><vaccination study><vaccination trial><vaccine associated immune response><vaccine boost><vaccine deployment><vaccine distribution><vaccine efficacy><vaccine immune response><vaccine immunogenicity><vaccine induced immune response><vaccine roll-out><vaccine rollout><vaccine study><vaccine trial><vaccines against malaria><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Abel Kakuru

STANFORD UNIVERSITY, STANFORD, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$563,176
FY 2026

Project Title

Perennial Malaria Chemoprevention in the Malaria Vaccine Era (PMC-VAC)

Grant Number:

1R01AI195195-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2033

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Malaria continues to result in 597,000 deaths annually, mainly due to Plasmodium Falciparum in young African children. An affordable malaria vaccine, R21, was recently approved by the World Health Organization (WHO) for infants beginning at 5-6 months of age and will soon be deployed in Uganda and o...

Research Terms

<0-11 years old><5 year old><5 years of age><Active Follow-up><Adverse Experience><Adverse event><Africa><African><Age><Age Months><Amodiaquin><Amodiaquine><Anti-malarials><Area><Artemisinins><Central Africa><Cessation of life><Chemoprevention><Child><Child Youth><Childhood><Children (0-21)><Clinical Trials><Combined Modality Therapy><Country><Daraprim><Death><Dose><Drug resistance><Drugs><Eastern Africa><Exposure to><Falciparum Malaria><Genetic Polymorphism><Immune response><Immunity><Immunization><Immunization Schedule><Incidence><Infant><Infection><Intervention><Life><Logistics><Long-Term Effects><Malaria><Malaria Vaccines><Malarial Vaccines><Medication><Memory><Morbidity><Multimodal Therapy><Multimodal Treatment><P falciparum><P. falciparum><P.falciparum><Paludism><Parasites><Pharmaceutical Preparations><Placebos><Plasmodium Infections><Plasmodium falciparum><Plasmodium falciparum Malaria><Prevalence><Pyrimethamine><Randomized><Recommendation><Regimen><Resistance><Safety><Schedule><Seasons><Series><Sham Treatment><Southern Africa><Study Subject><Sulfadoxine><Sulformethoxine><Sulformetoxine><Sulforthomidine><Sulphormetoxin><Testing><Time><Transmission><Uganda><Vaccination><Vaccines><Visit><World Health Organization><active followup><age 5><age 5 years><ages><anti-malarial agents><anti-malarial drugs><arm><arteannuin><artemisinine><booster dose><booster shot><booster vaccine><combination therapy><combined modality treatment><combined treatment><comparable efficacy><comparative efficacy><compare efficacy><deploy vaccines><distribute vaccines><drug resistant><drug/agent><five year old><five years of age><follow up><follow-up><followed up><followup><host response><immune response to vaccination><immune response to vaccines><immune system response><immunogenicity><immunoresponse><kids><malaria transmission><mortality><multi-modal therapy><multi-modal treatment><novel><pediatric><policy implication><polymorphism><primary end point><primary endpoint><programs><protective efficacy><qinghaosu><quing hau sau><quinghaosu><randomisation><randomization><randomly assigned><resistance to Drug><resistant><resistant to Drug><response><secondary end point><secondary endpoint><sham therapy><standard of care><transmission process><trial comparing><uptake><vaccination study><vaccination trial><vaccine associated immune response><vaccine boost><vaccine deployment><vaccine distribution><vaccine efficacy><vaccine immune response><vaccine immunogenicity><vaccine induced immune response><vaccine roll-out><vaccine rollout><vaccine study><vaccine trial><vaccines against malaria><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

HOLLY A. INGRAHAM

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

High-opportunity lead · 74/100
Likely hiring
Above-average budget
Very recent
Active award
$512,595
FY 2026

Project Title

Leveraging a Novel Neural Circuit for Urinary and Fecal Incontinence

Grant Number:

1R01DK147593-01

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract Interorgan communication between the brain and peripheral tissues maintains a range of adaptive responses that can degrade with aging. Using mouse models, we found a powerful neural circuit that simultaneously motivates spontaneous activity and overrides spinal reflexes that...

Research Terms

<21+ years old><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><Ablation><Adult><Adult Human><Affect><Aging><Agonist><Aminalon><Aminalone><Anal Incontinence><Anatomic Sites><Anatomic structures><Anatomy><Animals><Assay><Behavior><Behavioral><Bioassay><Biological Assay><Bladder><Bladder Control><Bladder Urinary System><Body Tissues><Bowel incontinence><Brain><Brain Nervous System><Brain region><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cells><Clostridium tetani Toxin><Colon><Communication><Complement><Complement Proteins><Connector Neuron><Cues><Data><Data Set><Defecation><Encephalon><Endocrine Gland Secretion><Engineering><Estrogens><Evaluation><Event><Excretory function><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Fecal Incontinence><Financial Hardship><Funding><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GABA><GPCR><Genetic><Glass><Goals><Health><Hind Brain><Hormones><Hour><Human><Hypothalamic structure><Hypothalamus><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intracellular Communication and Signaling><Light><Locus Coeruleus><Maps><Mediating><Medulla Spinalis><Methodology><Methods><Mice><Mice Mammals><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Murine><Mus><Nature><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroendocrine><Neuroendocrine System><Neuroendocrinology><Neurons><Neuropeptides><Neurosecretory Systems><Nucleus><Nucleus Pigmentosus Pontis><Organ><Pelvic><Pelvic Region><Pelvis><Peripheral><Photoradiation><Physiology><Pons><Pons Cerebelli><Pons Varolii><Pontine><Pontine structure><Population><Process><Public Health><Publishing><QOL><Quality of life><R21 Award><Reflex><Reflex action><Rejuvenation><Reporter><Research><Rhombencephalon><Saline><Saline Solution><Signal Transduction><Signal Transduction Systems><Signaling><Site><Spinal Cord><Stimulus><Synapses><Synaptic><System><TEV protease><Testing><Tetanus Toxin><Therapeutic Estrogen><Therapeutic Hormone><Therapeutic Steroid Hormone><Tissues><Tracer><Translating><Translations><Urinary Incontinence><Urination><Urine><Viral Vector><Wisconsin><Work><adulthood><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><aging population><behavior response><behavioral response><biological signal transduction><bladder continence><blue nucleus><bowel movement><complementation><conditioned fear><economic hardship><economic strain><elderly mice><excretion><fascinate><fear conditioning><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><frontier><gamma-Aminobutyric Acid><hindbrain><hypothalamic><improved><in vivo><inhibitory neuron><insight><locus ceruleus structure><micturition><micturition control><molecular profile><molecular signature><mouse model><murine model><neural circuit><neural circuitry><neurocircuitry><neuronal><novel><old mice><older adult><older adulthood><older women><pharmacologic><population aging><pre-clinical research><pre-clinical study><preclinical research><preclinical study><programs><promoter><promotor><response><restraint><scRNA sequencing><scRNA-seq><sex><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><spinal reflex><steroid hormone><synapse><synaptic circuit><synaptic circuitry><tobacco etch virus protease><tool><translation><urinary><urinary bladder><urinary continence><urinary control><urination control><γ-Aminobutyric Acid>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Taylor A Burke

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$839,023
FY 2026

Project Title

Enhancing Suicide Risk Detection through Computer Vision: a Novel Approach to Tissue Damage Analysis in Emergency Care

Grant Number:

1R01MH140004-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY Suicide is the second leading cause of death among youth and young adults ages 10-24, with rates having risen over 60% in the past 15 years. Emergency Department (ED) visits for psychiatric concerns among this population have also doubled, often prompted by suicide-related concerns. However,...

Research Terms

<10 year old><10 years of age><12 year old><12 years of age><AI Augmented><AI assisted><AI driven><AI enhanced><AI integrated><AI powered><Accident and Emergency department><Active Follow-up><Address><Affect><Algorithms><Area><Artificial Intelligence enhanced><Assessment instrument><Assessment tool><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Black><Black race><Body Tissues><Caring><Cause of Death><Cell Communication and Signaling><Cell Signaling><Cessation of life><Childhood><Cicatrix><Classification><Clinical><Computer Vision Systems><Cutaneous imaging><Data><Death><Deliberate Self-Harm><Dermatological Imaging><Detection><Development><Disparities><Disparity><Documentation><ED care><ED patient><ED visit><ER care><ER patient><ER visit><Electronic Health Record><Emergency Care><Emergency Department><Emergency Department care><Emergency Department patient><Emergency Room care><Emergency Room patient><Emergency care visit><Emergency department visit><Emergency health care><Emergency hospital visit><Emergency medical care><Emergency room><Emergency room visit><Frequencies><Future><Goals><Grant><Harvest><History><Hospital Administrators><Hospitals><Image><Infection><Interview><Intracellular Communication and Signaling><Judgment><Latine><Latinx><Machine Learning><Malignant Skin Neoplasm><Measures><Medical><Medical Imaging><Medical Records><Medicine><Memory><Methods><Modeling><Monitor><NIMH><National Institute of Mental Health><PRISM framework><PRISM model><Participant><Patient Self-Report><Patients><Performance><Personal awareness><Population><Postoperative><Postoperative Period><Practical Robust Implementation and Sustainability Model><Pragmatic, Robust Implementation and Sustainability Model><Predicting Risk><Procedures><Public Health><Recording of previous events><Reporting><Research><Research Priority><Risk><Risk Assessment><Sampling><Scars><Self Assessment><Self Perception><Self image><Self view><Self-Injurious Behavior><Self-Report><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Skin Cancer><Skin Imaging><Skin Tissue><Standardization><Suicide><Suicide attempt><Suicide precaution><Suicide prevention><System><Systematics><Techniques><Technology><Tissue imaging><Tissues><Visit><Youth><Youth 10-21><active followup><adult youth><age 10><age 10 years><age 12><age 12 years><algorithm training><arm><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><assessment app><assessment application><biological signal transduction><computer based prediction><computer vision><cutaneous tissue><deep learning><deep learning method><deep learning strategy><deliberate self harm><developmental><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><enhanced with AI><enhanced with Artificial Intelligence><ethnic bias><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><experience><fatal attempt><fatal suicide><follow up><follow-up><followed up><followup><forecasting risk><formative assessment><formative evaluation><health care settings><high risk><histories><imaging><implementation determinants><implementation factors><improved><indexing><innovate><innovation><innovative><inpatient psychiatric care><inpatient psychiatric treatment><insight><intent to die><intentional self harm><intentional self injury><machine based learning><malignant skin tumor><multi-racial><multiracial><new approaches><non fatal attempt><non-suicidal self injury><nonfatal attempt><nonsuicidal self injury><novel><novel approaches><novel strategies><novel strategy><pediatric><point of care><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive modeling><predictive risk><predicts risk><prevent suicidality><prevent suicide><prospective><psychiatric hospitalization><race bias><racial bias><racial minority group><racial minority individual><racial minority people><racial minority population><recruit><remote assessment><remote evaluation><risk prediction><risk prediction algorithm><risk prediction model><risk predictions><scale up><self awareness><self harm><self injury><self knowledge><suicidal><suicidal attempt><suicidal behavior><suicidal risk><suicidality><suicidality prevention><suicide behavior><suicide intervention><suicide rate><suicide risk><suicides><technology implementation><technology validation><ten year old><ten years of age><twelve year old><twelve years of age><young adult><young adult age><young adulthood><youth age>
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Manoj Bhasin

BETH ISRAEL DEACONESS MEDICAL CENTER, BOSTON, MA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$734,244
FY 2026

Project Title

Vascular-targeted Atheroprotective Gene therapies to Prevent Vein Graft Failure

Grant Number:

5R01HL173557-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/25/2024

End Date:

2/28/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Autologous vein grafts (VG) are the most commonly used conduits in revascularization procedures for coronary artery disease (CAD) and peripheral arterial disease (PAD). However, VG failure rates remain high, reaching 30- 50% for lower extremity bypass and over 50% for coronary artery bypass grafts (...

Research Terms

<(TNF)-α><ASCVD><Acceleration><Accounting><Address><Adeno-Associated Viruses><Angiogram><Angiography><Animal Model><Animal Models and Related Studies><Animals><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Aortocoronary Bypass><Apoptosis><Apoptosis Pathway><Apoptotic><Area><Arteries><Articulation><Atherogenicity><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Autologous><Biology><Biomedical Engineering><Blood Vessels><Body Tissues><Bypass><Cachectin><Canine Species><Canis familiaris><Cause of Death><Cell Body><Cell Growth in Number><Cell Locomotion><Cell Migration><Cell Movement><Cell Multiplication><Cell Proliferation><Cell-Extracellular Matrix><Cells><Cellular Migration><Cellular Motility><Cellular Proliferation><Cessation of life><Clinical><Collaborations><Common Femoral Artery><Common carotid artery><Complex><Coronary Arteriosclerosis><Coronary Artery Bypass><Coronary Artery Bypass Grafting><Coronary Artery Bypass Surgery><Coronary Artery Disease><Coronary Artery Disorder><Coronary Atherosclerosis><Coronary arterial bypass><DNA Therapy><Data><Death><Dependoparvovirus><Dependovirus><Development><Dogs><Dogs Mammals><Domestic Rabbit><ECM><Effectiveness><Endothelial Cells><Endothelium><Engineering><Ensure><Evaluation><Exhibits><Exploratory/Developmental Grant><Exposure to><Extracellular Matrix><Failure><Funding><Gene Therapy Vectors><Gene Transcription><Gene Transduction Agent><Gene Transduction Vectors><Gene Transfer Clinical><Genes><Genetic Intervention><Genetic Transcription><Government><Harvest><Hour><Human><Human Engineering><Hybrids><Hyperplasia><Hyperplastic><Image><Immune><Immunes><Immunoblotting><In Vitro><Inflammation><Inflammatory><Injury><Investigational Drugs><Investigational New Drugs><Laboratories><Lead><Leiomyocyte><Lesion><Load Bearing><Lower Extremity><Lower Limb><Macrophage><Macrophage-Derived TNF><Maps><Medical><Membrum inferius><Modeling><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Monocyte-Derived TNF><Morbidity><Mφ><Operative Procedures><Operative Surgical Procedures><Oryctolagus cuniculus><Outcome><Pathogenesis><Pathogenicity><Pathologic><Pathological Constriction><Patients><Pb element><Perfusion><Peripheral arterial disease><Persons><Phenotype><Pilot Projects><Procedures><Programmed Cell Death><Proliferating><Property><Proteins><Proteomics><R21 Mechanism><R21 Program><RNA Expression><Rabbits><Rabbits Mammals><Regimen><Research><Resistance><Risk Factors><Safety><Saphenous Vein><Scheme><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Stenosis><Surgical><Surgical Interventions><Surgical Procedure><System><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Technology><Temperature><Testing><Therapeutic><Therapeutic Agents><Therapeutic Studies><Therapy Research><Thrombosis><Time><Tissues><Toxic effect><Toxicities><Transcription><Transgenes><Trauma><Tropism><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Vascular Diseases><Vascular Disorder><Vascular remodeling><Vein graft><Veins><Weight Bearing><Weight-Bearing state><Western Blotting><Western Immunoblotting><Western World><adeno associated virus group><angiographic imaging><atheromatosis><atheroprotection><atheroprotective><atherosclerotic coronary disease><atherosclerotic disease><atherosclerotic vascular disease><bio-engineered><bio-engineers><bioengineering><biological engineering><blood vessel disorder><canine><cell motility><cephalic vein><circular RNA><clinic ready><clinical applicability><clinical application><clinical implementation><clinical ready><clinical translation><clinically translatable><closed circular RNA><coronary arterial disease><coronary bypass><developmental><domestic dog><efficacy study><ex vivo perfusion><exploratory developmental study><external jugular vein><gene regulatory network><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><global gene expression><global transcription profile><graft failure><heavy metal Pb><heavy metal lead><hemodynamics><human disease><imaging><implantation><improved><in vivo><injuries><model of animal><molecular profile><molecular signature><mortality><new technology><novel><novel technologies><pathogenicity gene><peripheral artery disease><pilot study><pre-clinical><preclinical><prevent><preventing><protein blotting><protein expression><recruit><resistant><response><revascularization><revascularization surgery><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><surgery><thrombotic><thrombotic disease><thrombotic disorder><tissue culture><transcriptome><transcriptomics><transgene><transgene expression><vascular><vascular dysfunction><vascular inflammation><vascular smooth muscle cell migration><vasculopathy><vector><viral RNA><virulence gene><virulent gene><virus RNA>
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CHRISTIANE FERRAN

BETH ISRAEL DEACONESS MEDICAL CENTER, BOSTON, MA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$734,244
FY 2026

Project Title

Vascular-targeted Atheroprotective Gene therapies to Prevent Vein Graft Failure

Grant Number:

5R01HL173557-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/25/2024

End Date:

2/28/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Autologous vein grafts (VG) are the most commonly used conduits in revascularization procedures for coronary artery disease (CAD) and peripheral arterial disease (PAD). However, VG failure rates remain high, reaching 30- 50% for lower extremity bypass and over 50% for coronary artery bypass grafts (...

Research Terms

<(TNF)-α><ASCVD><Acceleration><Accounting><Address><Adeno-Associated Viruses><Angiogram><Angiography><Animal Model><Animal Models and Related Studies><Animals><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Aortocoronary Bypass><Apoptosis><Apoptosis Pathway><Apoptotic><Area><Arteries><Articulation><Atherogenicity><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Autologous><Biology><Biomedical Engineering><Blood Vessels><Body Tissues><Bypass><Cachectin><Canine Species><Canis familiaris><Cause of Death><Cell Body><Cell Growth in Number><Cell Locomotion><Cell Migration><Cell Movement><Cell Multiplication><Cell Proliferation><Cell-Extracellular Matrix><Cells><Cellular Migration><Cellular Motility><Cellular Proliferation><Cessation of life><Clinical><Collaborations><Common Femoral Artery><Common carotid artery><Complex><Coronary Arteriosclerosis><Coronary Artery Bypass><Coronary Artery Bypass Grafting><Coronary Artery Bypass Surgery><Coronary Artery Disease><Coronary Artery Disorder><Coronary Atherosclerosis><Coronary arterial bypass><DNA Therapy><Data><Death><Dependoparvovirus><Dependovirus><Development><Dogs><Dogs Mammals><Domestic Rabbit><ECM><Effectiveness><Endothelial Cells><Endothelium><Engineering><Ensure><Evaluation><Exhibits><Exploratory/Developmental Grant><Exposure to><Extracellular Matrix><Failure><Funding><Gene Therapy Vectors><Gene Transcription><Gene Transduction Agent><Gene Transduction Vectors><Gene Transfer Clinical><Genes><Genetic Intervention><Genetic Transcription><Government><Harvest><Hour><Human><Human Engineering><Hybrids><Hyperplasia><Hyperplastic><Image><Immune><Immunes><Immunoblotting><In Vitro><Inflammation><Inflammatory><Injury><Investigational Drugs><Investigational New Drugs><Laboratories><Lead><Leiomyocyte><Lesion><Load Bearing><Lower Extremity><Lower Limb><Macrophage><Macrophage-Derived TNF><Maps><Medical><Membrum inferius><Modeling><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Monocyte-Derived TNF><Morbidity><Mφ><Operative Procedures><Operative Surgical Procedures><Oryctolagus cuniculus><Outcome><Pathogenesis><Pathogenicity><Pathologic><Pathological Constriction><Patients><Pb element><Perfusion><Peripheral arterial disease><Persons><Phenotype><Pilot Projects><Procedures><Programmed Cell Death><Proliferating><Property><Proteins><Proteomics><R21 Mechanism><R21 Program><RNA Expression><Rabbits><Rabbits Mammals><Regimen><Research><Resistance><Risk Factors><Safety><Saphenous Vein><Scheme><Smooth Muscle Cells><Smooth Muscle Myocytes><Smooth Muscle Tissue Cell><Stenosis><Surgical><Surgical Interventions><Surgical Procedure><System><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Technology><Temperature><Testing><Therapeutic><Therapeutic Agents><Therapeutic Studies><Therapy Research><Thrombosis><Time><Tissues><Toxic effect><Toxicities><Transcription><Transgenes><Trauma><Tropism><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Vascular Diseases><Vascular Disorder><Vascular remodeling><Vein graft><Veins><Weight Bearing><Weight-Bearing state><Western Blotting><Western Immunoblotting><Western World><adeno associated virus group><angiographic imaging><atheromatosis><atheroprotection><atheroprotective><atherosclerotic coronary disease><atherosclerotic disease><atherosclerotic vascular disease><bio-engineered><bio-engineers><bioengineering><biological engineering><blood vessel disorder><canine><cell motility><cephalic vein><circular RNA><clinic ready><clinical applicability><clinical application><clinical implementation><clinical ready><clinical translation><clinically translatable><closed circular RNA><coronary arterial disease><coronary bypass><developmental><domestic dog><efficacy study><ex vivo perfusion><exploratory developmental study><external jugular vein><gene regulatory network><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><global gene expression><global transcription profile><graft failure><heavy metal Pb><heavy metal lead><hemodynamics><human disease><imaging><implantation><improved><in vivo><injuries><model of animal><molecular profile><molecular signature><mortality><new technology><novel><novel technologies><pathogenicity gene><peripheral artery disease><pilot study><pre-clinical><preclinical><prevent><preventing><protein blotting><protein expression><recruit><resistant><response><revascularization><revascularization surgery><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><surgery><thrombotic><thrombotic disease><thrombotic disorder><tissue culture><transcriptome><transcriptomics><transgene><transgene expression><vascular><vascular dysfunction><vascular inflammation><vascular smooth muscle cell migration><vasculopathy><vector><viral RNA><virulence gene><virulent gene><virus RNA>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Benjamin Land

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$701,455
FY 2026

Project Title

Oral THC consumption during adolescence and its impact on adult mouse brain

Grant Number:

5R01DA061185-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Edibles that contain Δ9-tetrahyrocannabinol (THC), the principal psychoactive ingredient produced by the Cannabis plant, are becoming increasingly popular among adolescents, making examination of this method of use on the adolescent developing brain urgently needed. An ongoing collab...

Research Terms

<12-20 years old><21+ years old><Acute><Adolescence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adult><Adult Human><Animals><Applications Grants><Behavior><Behavioral><Biological><Biosensor><Brain><Brain Nervous System><Brain region><CB1><CB1 Receptor><CB1R><CNR1 gene><Cannabidiol><Cannabinoid Receptor CB1><Cannabinoids><Cannabis><Cell Communication and Signaling><Cell Signaling><Chocolate><Code><Coding System><Collaborations><Consumption><Data Collection><Development><Dopamine><Dose><Drug Exposure><Drug usage><Drugs><ECB signaling><Electrophysiology><Electrophysiology (science)><Encephalon><Endocannabinoids><Endogenous Cannabinoids><Ensure><Equilibrium><Experimental Designs><Exploratory Behavior><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Fiber><Formulation><Frequencies><Gel><Gelatin><Glutamates><Goals><Grant Proposals><Grooming><Hydroxytyramine><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><In Situ Hybridization><Intracellular Communication and Signaling><L-Glutamate><Laboratories><Long-Term Effects><Measures><Medication><Methods><Mice><Mice Mammals><Modeling><Molecular><Motivation><Murine><Mus><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neural Transmission><Neurocyte><Neurologic><Neurological><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Oral><Pathway interactions><Pharmaceutical Preparations><Photometry><Plants><Pre-Clinical Model><Preclinical Models><Procedures><Process><Publications><Publishing><R21 Award><Receptor Signaling><Regimen><Regulation><Rewards><Rodent><Rodentia><Rodents Mammals><Scientific Publication><Signal Transduction><Signal Transduction Systems><Signaling><Site><Slice><Structure><Synaptic Transmission><Synaptic plasticity><System><THC co-use><THC use><Testing><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Therapeutic><Validation><Work><adolescence (12-20)><adolescent brain development><adulthood><avoidance behavior><axon signaling><axon-glial signaling><axonal signaling><balance><balance function><behavior influence><behavior outcome><behavior phenotype><behavioral impairment><behavioral influence><behavioral outcome><behavioral phenotyping><biologic><biological sensor><biological signal transduction><cannabimimetics><cannabinoid receptor 1><cannabinoid receptor type 1><cannabinoid type 1><cannabis use><critical period><developmental><drug use><drug/agent><electrophysiological><endocannabinoid signaling><glia signaling><glial signaling><glutamatergic><iPS><iPSC><iPSCs><impaired behavior><in situ Hybridization Genetics><in situ Hybridization Staining Method><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><insight><juvenile><juvenile human><marijuana use><memory process><memory processing><motivated behavior><mouse model><murine model><nerve signaling><neural><neural circuit><neural circuitry><neural imaging><neural signaling><neuro-imaging><neurocircuitry><neuroimaging><neurological imaging><neuronal><neuronal signaling><neurotransmission><pathway><pharmacologic><phytocannabinoid><response><reward processing><spatial memory><supervised learning><supervised machine learning><synaptic circuit><synaptic circuitry><unsupervised learning><unsupervised machine learning><validations>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Nephi Stella

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$701,455
FY 2026

Project Title

Oral THC consumption during adolescence and its impact on adult mouse brain

Grant Number:

5R01DA061185-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2025

End Date:

3/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Edibles that contain Δ9-tetrahyrocannabinol (THC), the principal psychoactive ingredient produced by the Cannabis plant, are becoming increasingly popular among adolescents, making examination of this method of use on the adolescent developing brain urgently needed. An ongoing collab...

Research Terms

<12-20 years old><21+ years old><Acute><Adolescence><Adolescent><Adolescent Youth><Adolescent and Young Adult><Adult><Adult Human><Animals><Applications Grants><Behavior><Behavioral><Biological><Biosensor><Brain><Brain Nervous System><Brain region><CB1><CB1 Receptor><CB1R><CNR1 gene><Cannabidiol><Cannabinoid Receptor CB1><Cannabinoids><Cannabis><Cell Communication and Signaling><Cell Signaling><Chocolate><Code><Coding System><Collaborations><Consumption><Data Collection><Development><Dopamine><Dose><Drug Exposure><Drug usage><Drugs><ECB signaling><Electrophysiology><Electrophysiology (science)><Encephalon><Endocannabinoids><Endogenous Cannabinoids><Ensure><Equilibrium><Experimental Designs><Exploratory Behavior><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Fiber><Formulation><Frequencies><Gel><Gelatin><Glutamates><Goals><Grant Proposals><Grooming><Hydroxytyramine><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><In Situ Hybridization><Intracellular Communication and Signaling><L-Glutamate><Laboratories><Long-Term Effects><Measures><Medication><Methods><Mice><Mice Mammals><Modeling><Molecular><Motivation><Murine><Mus><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neural Transmission><Neurocyte><Neurologic><Neurological><Neuronal Transmission><Neurons><Neurophysiology / Electrophysiology><Oral><Pathway interactions><Pharmaceutical Preparations><Photometry><Plants><Pre-Clinical Model><Preclinical Models><Procedures><Process><Publications><Publishing><R21 Award><Receptor Signaling><Regimen><Regulation><Rewards><Rodent><Rodentia><Rodents Mammals><Scientific Publication><Signal Transduction><Signal Transduction Systems><Signaling><Site><Slice><Structure><Synaptic Transmission><Synaptic plasticity><System><THC co-use><THC use><Testing><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Therapeutic><Validation><Work><adolescence (12-20)><adolescent brain development><adulthood><avoidance behavior><axon signaling><axon-glial signaling><axonal signaling><balance><balance function><behavior influence><behavior outcome><behavior phenotype><behavioral impairment><behavioral influence><behavioral outcome><behavioral phenotyping><biologic><biological sensor><biological signal transduction><cannabimimetics><cannabinoid receptor 1><cannabinoid receptor type 1><cannabinoid type 1><cannabis use><critical period><developmental><drug use><drug/agent><electrophysiological><endocannabinoid signaling><glia signaling><glial signaling><glutamatergic><iPS><iPSC><iPSCs><impaired behavior><in situ Hybridization Genetics><in situ Hybridization Staining Method><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><insight><juvenile><juvenile human><marijuana use><memory process><memory processing><motivated behavior><mouse model><murine model><nerve signaling><neural><neural circuit><neural circuitry><neural imaging><neural signaling><neuro-imaging><neurocircuitry><neuroimaging><neurological imaging><neuronal><neuronal signaling><neurotransmission><pathway><pharmacologic><phytocannabinoid><response><reward processing><spatial memory><supervised learning><supervised machine learning><synaptic circuit><synaptic circuitry><unsupervised learning><unsupervised machine learning><validations>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

John J Pacella

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$695,478
FY 2026

Project Title

Focal Myocardial Delivery of Small Molecule Nitroalkenes using Ultrasound Targeted Microbubble Cavitation to Improve Ventricular Recovery Following Myocardial Infarction

Grant Number:

5R01HL173319-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/4/2025

End Date:

12/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Myocardial infarction (MI) causes two major problems, microvascular obstruction (MVO) and myocardial fibrosis. MVO occurs after downstream embolization during percutaneous coronary intervention for MI in most patients and is a strong independent predictor of major adverse events, including mortality...

Research Terms

<ASCVD><Acute><Acute myocardial infarct><Acute myocardial infarction><Address><Adverse Experience><Adverse event><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Area><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Atrial><Blood Vessels><Body Tissues><Bone-Derived Transforming Growth Factor><Bypass><Cardiac><Cardiac Atrium><Cardiac Failure Congestive><Cardiac infarction><Cardiology><Cardiovascular Models><Cause of Death><Cell Communication and Signaling><Cell Signaling><Chronic><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Cicatrix><Clinical><Common Rat Strains><Congestive Heart Failure><Contrast Agent><Contrast Drugs><Contrast Media><Coronary Reperfusion><Development><Dose><Drug Delivery><Drug Delivery Systems><Drug Targeting><Drugs><Embolization Therapy><Embolotherapy><Environment><Event><Fatty Acids><Fibrosis><Fibrosis in the heart><Fibrosis in the myocardium><Fibrosis within the heart><Fibrosis within the myocardium><Fibrotic myocardium><Formulation><Foundations><Gases><Gene Expression><Heart Atrium><Heart Decompensation><Hepatic><Hindlimb><Human><Infarction><Inflammation><Inflammation Mediators><Inflammatory><Inflammatory Response><Injections><Injury><Intervention><Intracellular Communication and Signaling><Intravenous><Ischemia><Ischemia-Reperfusion Injury><Ischemic Heart><Ischemic Heart Disease><Ischemic myocardium><LVEF><Left Ventricular Dysfunction><Left Ventricular Ejection Fraction><Left Ventricular Function><Lipids><Local Therapy><Localized Therapy><Mechanics><Mediating><Medication><Methods><Microbubbles><Microcirculation><Milk Growth Factor><Modeling><Modern Man><Myocardial><Myocardial Infarct><Myocardial Infarction><Myocardial Ischemia><Myocardial Ischemic Reperfusion Injury><Myocardial Reperfusion><Myocardial Reperfusion Injury><Myocardium><NIH><National Institutes of Health><Nature><Obesity><Obstruction><Oral><Outcome><Pathology><Patients><Perfusion><Pharmaceutical Preparations><Phase 2 Clinical Trials><Phase II Clinical Trials><Phosphatides><Phospholipids><Platelet Transforming Growth Factor><Radiopaque Media><Rat><Rats Mammals><Rattus><Recovery><Reperfusion Damage><Reperfusion Injury><Reperfusion Therapy><Research><Rodent><Rodent Model><Rodentia><Rodents Mammals><Rupture><Scars><Signal Transduction><Signal Transduction Systems><Signaling><Site><Structure><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Techniques><Testing><Therapeutic><Therapeutic Effect><Therapeutic Embolization><Thrombus><Time><Tissues><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><United States National Institutes of Health><Ventricular><Ventricular Function><Work><adiposity><airway epithelium inflammation><airway inflammation><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><biological signal transduction><cardiac fibrosis><cardiac function><cardiac infarct><cardiac ischemia><cardiac muscle><chronic heart failure><chronic kidney disease><clinical relevance><clinically relevant><compare to control><comparison control><coronary attack><coronary fibrosis><coronary infarct><coronary infarction><coronary ischemia><corpulence><determine efficacy><developmental><drug/agent><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><embolization><evaluate efficacy><examine efficacy><fibrotic heart><function of the heart><heart attack><heart fibrosis><heart function><heart infarct><heart infarction><heart ischemia><heart muscle><improved><infarct><inflammatory mediator><injuries><intermolecular interaction><interstitial><left ventricle abnormality><mechanic><mechanical><mortality><myocardial fibrosis><myocardial ischemia/hypoxia><myocardium ischemia><nitroalkene><novel><percutaneous coronary intervention><phase II protocol><pig model><piglet model><porcine model><pre-clinical><preclinical><preservation><reperfusion><respiratory inflammation><respiratory tract inflammation><response><restenosis><site targeted delivery><small molecule><swine model><targeted delivery><ultrasound><vascular><vibration>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

GEORGETTE D. KANMOGNE

UNIVERSITY OF NEBRASKA MEDICAL CENTER, OMAHA, NE

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$690,748
FY 2026

Project Title

PREVENTING ALZHEIMER’S DISEASE-LIKE BRAIN PATHOLOGY IN HIV INFECTION BY TARGETING CCR5

Grant Number:

5R01MH132517-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2023

End Date:

1/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT Brain tissues from people living with HIV (PLWH) showed evidence of Alzheimer’s Disease (AD)-like pathologies, including increased neurotoxic amyloid-b (Ab40/42), amyloid plaques and Tau hyperphosphorylation (pTau) associated with neurodegeneration and HIV-associated neurocognitive ...

Research Terms

<ACT2><AD dementia><AD like pathology><AGE receptor><AIDS Virus><AIDS prevention><AIDS/HIV><APP processing><AT744.1><AZT><Abeta synthesis><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Act-2><Address><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer like pathology><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease like pathology><Alzheimer's precursor protein><Alzheimers Dementia><Amyloid (Aβ) plaques><Amyloid A4 Protein Precursor><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid Protein Precursor><Amyloid beta-Protein><Amyloid beta-Protein Precursor><Amyloid β><Amyloid β production><Amyloid β synthesis><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β-Protein Precursor><Animal Model><Animal Models and Related Studies><Anti-Retroviral Agents><Apo E Receptor><ApoE Receptor><Apolipoprotein E Receptor><Area><Autopsy><Azidothymidine><Aβ><Aβ production><Aβ synthesis><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BACE><BACE1><BCDF><BSF-2><BSF2><Blood - brain barrier anatomy><Blood-Brain Barrier><Brain><Brain Nervous System><Brain Pathology><Brain Vascular><Brain Vascular Trauma><C-C CKR-5><C-C CKR-5 Gene><C-C Chemokine Receptor Type 5><C-C Chemokine Receptor Type 5 Gene><CC Chemokine Receptor 5><CC-CKR-5><CC-CKR-5 Gene><CC-CKR5><CCCKR5><CCCKR5 Gene><CCL4><CCL4 gene><CCL5><CCR-5><CCR-5 Gene><CCR5><CCR5 Protein><CCR5 Receptors><CCR5 gene><CD10 Antigens><CD195 Antigen><CD195 Antigen Gene><CHEMR13><CHEMR13 Gene><CKR-5><CKR-5 Gene><CKR5><CKR5 Gene><CKR5 Receptors><CMKBR5><CMKBR5 Gene><CNS Injury><CNS Nervous System><Catabolism><Cell Body><Cells><Central Nervous System><Cerebrovascular Trauma><Cerebrovascular system><Chemokine (C-C Motif) Ligand 4><Chemokine (C-C Motif) Ligand 5><Chemokine (C-C Motif) Receptor 5><Chemokine (C-C) Receptor 5><Chemokine (C-C) Receptor 5 Gene><Chemokine, CC Motif, Ligand 4><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><D17S136E><Development><Disturbance in cognition><Down-Regulation><Drugs><Dysfunction><Encephalon><Endocytosis><Endothelium><Enkephalinase><Enzyme Gene><Enzymes><Esteroproteases><Functional disorder><Gene Transcription><Genes><Genetic Transcription><HIV><HIV 1 associated neurocognitive disorder><HIV Infections><HIV Prevention><HIV associated neurocognitive deficit><HIV associated neurocognitive impairment><HIV individuals><HIV induced neurocognitive deficit><HIV induced neurocognitive impairment><HIV infected individuals><HIV infected persons><HIV neurocognitive impairment><HIV people><HIV positive individuals><HIV positive people><HIV viral infection><HIV virus infection><HIV-1><HIV-1 Fusion Co-Receptor><HIV-1 Fusion Co-Receptor Gene><HIV-1 associated neurocognitive deficit><HIV-1 associated neurocognitive disorder><HIV-1 associated neurocognitive impairment><HIV-1 infection><HIV-1 prevention><HIV-I><HIV-associated neurocognitive disorder><HIV/AIDS><HIV/AIDS prevention><HIV1><HPGF><Hemato-Encephalic Barrier><Hepatocyte-Stimulating Factor><Human><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><IQ Deficit><Immune Activation 2><Impaired cognition><Impairment><In Vitro><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Injury><Interleukin-6><Intermediary Metabolism><Kinases><LAV-HTLV-III><LDL-Receptor Related Protein 1><Lipoproteins><Low Density Lipoprotein Receptor-Related Protein><Low-Density-Lipoprotein Receptor-Related Protein-1><Lymphadenopathy-Associated Virus><MGC17164><MGI-2><MIP1B><MIP1B1><MT-bound tau><Macrophage><Macrophage Inflammatory Protein 1-Beta><Mediating><Medication><Membrane Metalloendopeptidase><Metabolic Processes><Metabolism><Modern Man><Molecular Fingerprinting><Molecular Profiling><Myeloid Differentiation-Inducing Protein><Mφ><NIH><National Institutes of Health><Neprilysin><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neuraxis><Neuritic Plaques><Neurocognitive Deficit><Neurocognitive Impairment in HIV><Neurocognitive Impairment in HIV-1><Neurocyte><Neurofibrillary Tangles><Neuron Degeneration><Neurons><Neutral Endopeptidase><PLWH><PWH><Pathology><Pathway interactions><Peptidases><Peptide Hydrolases><Pharmaceutical Preparations><Phosphotransferase Gene><Phosphotransferases><Physiopathology><Plasmacytoma Growth Factor><Play><Prevent HIV><Primary Senile Degenerative Dementia><Production><Protease Gene><Proteases><Proteinases><Proteolytic Enzymes><RAGE receptor><RANTES><RNA Expression><Receptor Protein><Regimen><Research Priority><Role><SCYA4><SCYA5><SIS delta><SIS-delta><SISd><Senile Plaques><Small Inducible Cytokine A4><Small Inducible Cytokine A5><Structure><System><T-Cell RANTES Protein><T-Cell Specific Protein p288><TCP228><Tenofovir><Testing><Therapeutic><Transcription><Transphosphorylases><United States National Institutes of Health><Upregulation><Vascular Brain Injury><Vascular Endothelium><Viral Burden><Viral Load><Viral Load result><Viread><Virus-HIV><ZDV><Zidovudine><a beta peptide><abeta><abeta production><advanced glycosylation end product receptor><alpha-2-Macroglobulin Receptor><alpha2-Macroglobulin Signaling Receptor><amphoterin receptor><amyloid assembly><amyloid beta><amyloid beta plaque><amyloid beta production><amyloid beta synthesis><amyloid formation><amyloid precursor protein><amyloid precursor protein processing><amyloid-b plaque><amyloid-b protein><amyloidogenesis><antagonism><antagonist><anti-retroviral><antiretroviral therapy><antiretroviral treatment><azidodeoxythymidine><aβ plaques><beta amyloid fibril><beta-secretase 1><beta-site APP cleaving enzyme 1><beta-site amyloid precursor protein cleaving enzyme 1><blood vessels in the brain><bloodbrain barrier><brain amyloidogenesis><brain blood vessels><brain microvasculature><brain microvessels><brain tissue><brain vasculature><central nervous system injury><cerebral blood vessel><cerebral microvasculature><cerebral microvessels><cerebral vascular><cerebral vascular injury><cerebral vasculature><cerebro-vascular><cerebrovascular><cerebrovascular injury><cerebrovascular vessels><cerebrovasculature><cognitive dysfunction><cognitive loss><cored plaque><design><designing><developmental><diffuse plaque><drug/agent><epigenome><epigenomics><global gene expression><global transcription profile><human immunodeficiency virus infection><humanized mice><humanized mouse><hyper-phosphorylated tau><hyperphosphorylated tau><in vivo><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><injured CNS><injuries><intelligence quotient deficit><interferon beta 2><memapsin 2><microtubule bound tau><microtubule-bound tau><model of animal><molecular profile><molecular signature><necropsy><nerve cell death><nerve cell loss><neural degeneration><neural inflammation><neurocognitive decline><neurocognitive impairment><neurodegeneration><neurodegenerative><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neurofibrillary tangle formation><neuroinflammation><neuroinflammatory><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><neurotoxic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><p-tau><p-τ><pathophysiology><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><phospho-tau><phospho-τ><phosphorylated tau><post-translational modification of tau><postmortem><posttranslational modification of tau><prevent><prevent AIDS><prevent human immunodeficiency virus><preventing><primary degenerative dementia><protective effect><receptor><receptor expression><receptor for AGE><receptor for advanced glycation end product><receptor for advanced glycation endproducts><receptor of AGE><senile dementia of the Alzheimer type><social role><soluble amyloid precursor protein><tangle><tangle formation><tau><tau Proteins><tau factor><tau phosphorylation><tau posttranslational modification><tau-1><transcriptome><transcriptomics><uptake><β-secretase 1><β-site APP cleaving enzyme 1><τ Proteins><τ phosphorylation>
View Full Project Details on NIH Reporter
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Helen Julia Burgess

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$666,732
FY 2026

Project Title

At Home Morning Bright Light Treatment For Chronic Nociplastic Pain

Grant Number:

5R01NR021025-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/11/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Fibromyalgia (FM) is the quintessential nociplastic pain condition and is characterized by chronic widespread pain, mood and sleep disturbance, fatigue, and cognitive dysfunction, and affects >20 million Americans. Functional impairment is common and having one or more demographic risk factors such ...

Research Terms

<Actinotherapy><Active Follow-up><Adherence><Adverse effects><Affect><After Care><After-Treatment><Aftercare><Age><American><Area><Biological><Chronic><Clinical><Clinical Trials><Cognition Therapy><Cognitive Disturbance><Cognitive Impairment><Cognitive Psychotherapy><Cognitive Therapy><Cognitive decline><Cognitive function abnormal><Cognitive treatment><Communities><Demographic Impact><Development><Devices><Diffuse Myofascial Pain Syndrome><Disturbance in cognition><Drug Therapy><Economic Income><Economical Income><Economics><Education><Educational aspects><Elements><Emotional Depression><Employment><Enrollment><Exercise><Fatigue><Fibromyalgia><Fibromyositis-Fibromyalgia Syndrome><Fibrositis><Functional impairment><Guidelines><Health Insurance><Home><Hour><Impaired cognition><Income><Individual><Insurance><Lack of Energy><Light><Light Therapy><MPD syndrome><Mediating><Medical><Mental Depression><Meta-Analysis><Muscular Rheumatism><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Pain><Pain intensity><Painful><Participant><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Persons><Pharmacological Treatment><Pharmacotherapy><Photoradiation><Photoradiation Therapy><Phototherapy><Physiatric Procedure><Physical Medicine Procedure><Physical Therapeutics><Physical therapy><Physiotherapy><Productivity><QOL><Quality of life><Randomized><Research><Research Resources><Resources><Risk><Risk Factors><Rural Community><Sampling><Self Administered><Self Administration><Sleep disturbances><Social support><Symptom Burden><Symptoms><Testing><aberrant sleep><active followup><affective disturbance><ages><biologic><care as usual><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><chronic widespread pain><circadian><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cognitive dysfunction><cognitive loss><depression><depression symptom><depressive><depressive symptoms><deprivation><developmental><disrupted sleep><disturbance in affect><disturbed sleep><drug intervention><drug treatment><economic><enroll><experience><fibromyalgia pain><fibromyalgia syndrome><follow up><follow-up><followed up><followup><functional improvement><health insurance plan><homes><impaired sleep><improve function><improved><improved functional outcomes><improved outcome><improvement on sleep><incomes><indexing><irregular sleep><light intervention><light treatment><male><mood alteration><mood and affect disturbance><mood disturbance><mood dysfunction><myofascial pain dysfunction syndrome><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><novel><optimal therapies><optimal treatments><pain in fibromyalgia><pain outcome><pain-related outcome><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><post treatment><primary outcome><quality of sleep><randomisation><randomization><randomly assigned><response to therapy><response to treatment><side effect><sleep amount><sleep disruption><sleep duration><sleep dysregulation><sleep episode><sleep improvement><sleep interval><sleep length><sleep period><sleep quality><sleep quantity><sleep time><sleep/wake disruption><sleep/wake disturbance><social support network><social vulnerability><symptom treatment><symptomatic treatment><therapeutic response><therapy response><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><treat chronic pain><treat symptom><treatment adherence><treatment as usual><treatment compliance><treatment effect><treatment group><treatment response><treatment responsiveness><usual care><virtual assessment><virtual evaluation><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><♂>
View Full Project Details on NIH Reporter
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Afton L Hassett

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$666,732
FY 2026

Project Title

At Home Morning Bright Light Treatment For Chronic Nociplastic Pain

Grant Number:

5R01NR021025-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/11/2024

End Date:

3/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Fibromyalgia (FM) is the quintessential nociplastic pain condition and is characterized by chronic widespread pain, mood and sleep disturbance, fatigue, and cognitive dysfunction, and affects >20 million Americans. Functional impairment is common and having one or more demographic risk factors such ...

Research Terms

<Actinotherapy><Active Follow-up><Adherence><Adverse effects><Affect><After Care><After-Treatment><Aftercare><Age><American><Area><Biological><Chronic><Clinical><Clinical Trials><Cognition Therapy><Cognitive Disturbance><Cognitive Impairment><Cognitive Psychotherapy><Cognitive Therapy><Cognitive decline><Cognitive function abnormal><Cognitive treatment><Communities><Demographic Impact><Development><Devices><Diffuse Myofascial Pain Syndrome><Disturbance in cognition><Drug Therapy><Economic Income><Economical Income><Economics><Education><Educational aspects><Elements><Emotional Depression><Employment><Enrollment><Exercise><Fatigue><Fibromyalgia><Fibromyositis-Fibromyalgia Syndrome><Fibrositis><Functional impairment><Guidelines><Health Insurance><Home><Hour><Impaired cognition><Income><Individual><Insurance><Lack of Energy><Light><Light Therapy><MPD syndrome><Mediating><Medical><Mental Depression><Meta-Analysis><Muscular Rheumatism><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Pain><Pain intensity><Painful><Participant><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Persons><Pharmacological Treatment><Pharmacotherapy><Photoradiation><Photoradiation Therapy><Phototherapy><Physiatric Procedure><Physical Medicine Procedure><Physical Therapeutics><Physical therapy><Physiotherapy><Productivity><QOL><Quality of life><Randomized><Research><Research Resources><Resources><Risk><Risk Factors><Rural Community><Sampling><Self Administered><Self Administration><Sleep disturbances><Social support><Symptom Burden><Symptoms><Testing><aberrant sleep><active followup><affective disturbance><ages><biologic><care as usual><chronic pain><chronic pain control><chronic pain intervention><chronic pain management><chronic pain therapy><chronic pain treatment><chronic widespread pain><circadian><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cognitive dysfunction><cognitive loss><depression><depression symptom><depressive><depressive symptoms><deprivation><developmental><disrupted sleep><disturbance in affect><disturbed sleep><drug intervention><drug treatment><economic><enroll><experience><fibromyalgia pain><fibromyalgia syndrome><follow up><follow-up><followed up><followup><functional improvement><health insurance plan><homes><impaired sleep><improve function><improved><improved functional outcomes><improved outcome><improvement on sleep><incomes><indexing><irregular sleep><light intervention><light treatment><male><mood alteration><mood and affect disturbance><mood disturbance><mood dysfunction><myofascial pain dysfunction syndrome><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><novel><optimal therapies><optimal treatments><pain in fibromyalgia><pain outcome><pain-related outcome><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><post treatment><primary outcome><quality of sleep><randomisation><randomization><randomly assigned><response to therapy><response to treatment><side effect><sleep amount><sleep disruption><sleep duration><sleep dysregulation><sleep episode><sleep improvement><sleep interval><sleep length><sleep period><sleep quality><sleep quantity><sleep time><sleep/wake disruption><sleep/wake disturbance><social support network><social vulnerability><symptom treatment><symptomatic treatment><therapeutic response><therapy response><time asleep><time during sleep><time in sleep><time spent asleep><time spent sleeping><treat chronic pain><treat symptom><treatment adherence><treatment as usual><treatment compliance><treatment effect><treatment group><treatment response><treatment responsiveness><usual care><virtual assessment><virtual evaluation><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><♂>
View Full Project Details on NIH Reporter
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Kejia Cai

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$628,443
FY 2026

Project Title

Noninvasive High-Resolution Mapping of HCC Tumor Biology Predictive of Malignancy

Grant Number:

5R01CA283548-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/11/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT: Hepatocellular carcinoma (HCC) is an aggressive malignancy representing the 7th most common cancer globally and the 4th most common cause of cancer death worldwide. Although magnetic resonance imaging (MRI) represents a common HCC diagnostic and prognostic tool, MRI fails to provid...

Research Terms

<Ablation><Abscission><Address><Area><Artifacts><Biochemical><Biopsy><Blood Serum><Blood Vessels><CK MiMi><CRISPR><CRISPR/Cas system><Cancer Cause><Cancer Etiology><Cancer Model><CancerModel><Cancers><Cell Body><Cells><Cessation of life><Characteristics><Chemicals><Clinical><Clinical Management><Clustered Regularly Interspaced Short Palindromic Repeats><Collection><Creatine><Creatine Phosphate><Curative Surgery><Cytosol><Death><Development><Diagnosis><Diagnostic><Differential Display><Diffusion><Engineering><Evaluation><Excision><Extirpation><Family suidae><Funding><Gene Targeting><Generalized Growth><Genes><Genetic Heterogeneity><Goals><Grant><Growth><Hepatic Cancer><Hepatocarcinoma><Hepatocarcinoma model><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Heterogeneity><Human><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><In Vitro><Intermediary Metabolism><Intratumoral heterogeneity><Invaded><KRAS(G12D)><KRASG12D><Kinetics><Knock-out><Knockout><Knowledge><Liver><Liver Cells Carcinoma><Location><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malignant><Malignant - descriptor><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of liver><Maps><Measurement><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metabolic><Metabolic Processes><Metabolism><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Monitor><Morphologic artifacts><Motion><NMR Imaging><NMR Tomography><Natural regeneration><Nodule><Nuclear Magnetic Resonance Imaging><Oncopig><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Performance><Phosphocreatine><Phosphorylcreatine><Pigs><Population><Primary Malignant Neoplasm of Liver><Primary carcinoma of the liver cells><Primary liver cancer><Prognosis><Proliferating><Protocol><Protocols documentation><RF ablation><Radio Frequency Ablation><Radiofrequency Ablation><Radiofrequency Interstitial Ablation><Recurrence><Recurrent><Regeneration><Removal><Resolution><Respiration><Risk Assessment><Sensitivity and Specificity><Serum><Suidae><Surgical Removal><Survival Rate><Swine><System><Techniques><Testing><Therapeutic><Tissue Growth><Transgenic Organisms><Tumor Biology><Tumor Burden><Tumor Load><Zeugmatography><cancer cell metabolism><cancer metabolism><cancer progression><clinical practice><clinical relevance><clinically relevant><developmental><diagnostic biomarker><diagnostic marker><diagnostic tool><differential display technique><diffused><diffuses><diffusing><diffusions><effective therapy><effective treatment><empowerment><genetic profiling><hepatic body system><hepatic organ system><hepatocellular carcinoma cancer model><hepatocellular carcinoma model><heterogeneity in tumors><imaging><improved><in vivo><innovate><innovation><innovative><insight><intra-tumoral heterogeneity><intrahepatic><intratumor heterogeneity><knock-down><knockdown><liver cancer><liver cancer model><liver cancer patient><liver carcinoma><liver malignancy><mRNA Differential Displays><malignancy><malignant liver tumor><migration><mitochondrial creatine kinase><molecular profile><molecular signature><multidisciplinary><neoplasm progression><neoplasm/cancer><neoplastic progression><non-invasive imaging><noninvasive imaging><ontogeny><overexpress><overexpression><patient oriented outcomes><patient prognosis><pig model><piglet model><porcine><porcine model><prognostic tool><regenerate><research study><resection><resolutions><respiratory><respiratory mechanism><response to therapy><response to treatment><risk stratification><stratify risk><suid><swine model><therapeutic response><therapeutic stratification><therapy response><transgenic><treatment response><treatment responsiveness><treatment stratification><tumor><tumor cell metabolism><tumor growth><tumor heterogeneity><tumor metabolism><tumor progression><vascular>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ron C Gaba

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$628,443
FY 2026

Project Title

Noninvasive High-Resolution Mapping of HCC Tumor Biology Predictive of Malignancy

Grant Number:

5R01CA283548-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/11/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT: Hepatocellular carcinoma (HCC) is an aggressive malignancy representing the 7th most common cancer globally and the 4th most common cause of cancer death worldwide. Although magnetic resonance imaging (MRI) represents a common HCC diagnostic and prognostic tool, MRI fails to provid...

Research Terms

<Ablation><Abscission><Address><Area><Artifacts><Biochemical><Biopsy><Blood Serum><Blood Vessels><CK MiMi><CRISPR><CRISPR/Cas system><Cancer Cause><Cancer Etiology><Cancer Model><CancerModel><Cancers><Cell Body><Cells><Cessation of life><Characteristics><Chemicals><Clinical><Clinical Management><Clustered Regularly Interspaced Short Palindromic Repeats><Collection><Creatine><Creatine Phosphate><Curative Surgery><Cytosol><Death><Development><Diagnosis><Diagnostic><Differential Display><Diffusion><Engineering><Evaluation><Excision><Extirpation><Family suidae><Funding><Gene Targeting><Generalized Growth><Genes><Genetic Heterogeneity><Goals><Grant><Growth><Hepatic Cancer><Hepatocarcinoma><Hepatocarcinoma model><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Heterogeneity><Human><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><In Vitro><Intermediary Metabolism><Intratumoral heterogeneity><Invaded><KRAS(G12D)><KRASG12D><Kinetics><Knock-out><Knockout><Knowledge><Liver><Liver Cells Carcinoma><Location><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malignant><Malignant - descriptor><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of liver><Maps><Measurement><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metabolic><Metabolic Processes><Metabolism><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Monitor><Morphologic artifacts><Motion><NMR Imaging><NMR Tomography><Natural regeneration><Nodule><Nuclear Magnetic Resonance Imaging><Oncopig><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Performance><Phosphocreatine><Phosphorylcreatine><Pigs><Population><Primary Malignant Neoplasm of Liver><Primary carcinoma of the liver cells><Primary liver cancer><Prognosis><Proliferating><Protocol><Protocols documentation><RF ablation><Radio Frequency Ablation><Radiofrequency Ablation><Radiofrequency Interstitial Ablation><Recurrence><Recurrent><Regeneration><Removal><Resolution><Respiration><Risk Assessment><Sensitivity and Specificity><Serum><Suidae><Surgical Removal><Survival Rate><Swine><System><Techniques><Testing><Therapeutic><Tissue Growth><Transgenic Organisms><Tumor Biology><Tumor Burden><Tumor Load><Zeugmatography><cancer cell metabolism><cancer metabolism><cancer progression><clinical practice><clinical relevance><clinically relevant><developmental><diagnostic biomarker><diagnostic marker><diagnostic tool><differential display technique><diffused><diffuses><diffusing><diffusions><effective therapy><effective treatment><empowerment><genetic profiling><hepatic body system><hepatic organ system><hepatocellular carcinoma cancer model><hepatocellular carcinoma model><heterogeneity in tumors><imaging><improved><in vivo><innovate><innovation><innovative><insight><intra-tumoral heterogeneity><intrahepatic><intratumor heterogeneity><knock-down><knockdown><liver cancer><liver cancer model><liver cancer patient><liver carcinoma><liver malignancy><mRNA Differential Displays><malignancy><malignant liver tumor><migration><mitochondrial creatine kinase><molecular profile><molecular signature><multidisciplinary><neoplasm progression><neoplasm/cancer><neoplastic progression><non-invasive imaging><noninvasive imaging><ontogeny><overexpress><overexpression><patient oriented outcomes><patient prognosis><pig model><piglet model><porcine><porcine model><prognostic tool><regenerate><research study><resection><resolutions><respiratory><respiratory mechanism><response to therapy><response to treatment><risk stratification><stratify risk><suid><swine model><therapeutic response><therapeutic stratification><therapy response><transgenic><treatment response><treatment responsiveness><treatment stratification><tumor><tumor cell metabolism><tumor growth><tumor heterogeneity><tumor metabolism><tumor progression><vascular>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Rebecca Ashare

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$621,825
FY 2026

Project Title

Hybrid Trial of a Tailored Smoking Cessation Digital Therapeutic for Persons Living with HIV

Grant Number:

5R01CA285331-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/9/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT Tobacco use has alarmingly high rates among people with HIV (PWH), 43% compared with 15% in the general population. Due to the development of highly effective treatments for HIV and the resulting increased longevity among PWH, this population now loses more life years to smoking tha...

Research Terms

<AIDS Virus><AIDS focused research><AIDS related research><AIDS related stigma><AIDS research><AIDS science><AIDS specific research><AIDS stigma><Abstinence><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adherence><African American><Afro American><Afroamerican><Anti-Retroviral Agents><Area><Assess implementation><Behavioral><Biochemical><Cancer Control><Cancer Control Science><Cancers><Cigarette><Clinic><Clinical><Clinical Practice Guideline><Clinical effectiveness><Cognitive deficits><Communities><Confidence Intervals><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Control Groups><Data><Development><Disease><Disorder><Effectiveness><Electronic cigarette><Future><General Population><General Public><Guidelines><HIV><HIV Infections><HIV associated stigma><HIV focused research><HIV individuals><HIV infected individuals><HIV infected persons><HIV internalized stigma><HIV intervention><HIV investigation><HIV people><HIV positive individuals><HIV positive people><HIV related research><HIV related stigma><HIV research><HIV science><HIV specific research><HIV stigma><HIV therapeutic><HIV therapy><HIV treatment><HIV viral infection><HIV virus infection><HIV-1 infection><HIV-1 intervention><HIV-1 therapeutic><HIV-1 therapy><HIV-1 treatment><HIV-based discrimination><HIV-related discrimination><HIV-related social stigma><HIV/AIDS stigma><Health><Health Care Providers><Health Personnel><Human Immunodeficiency Virus therapy><Human Immunodeficiency Virus treatment><Human Immunodeficiency Viruses><Hybrids><Implementation assessment><Improve Access><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Intervention><Interview><Investigation on HIV><LAV-HTLV-III><Learning><Length of Life><Life><Longevity><Lymphadenopathy-Associated Virus><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Measures><Mental Health><Mental Hygiene><Methodology><Methods><Modeling><Morbidity><NCI Organization><NIH><National Cancer Institute><National Institutes of Health><Nicotine Replacement Therapy><Outcome><PLWH><PWH><Patient Self-Report><Patients><Persons><Phase><Pilot Projects><Play><Population><Population Intervention><Psychological Health><Public Health><Pulmonary Cancer><Pulmonary malignant Neoplasm><QOL><Quality of life><Randomized, Controlled Trials><Recommendation><Reporting><Research><Research Design><Research Priority><Sampling><Secure><Self-Report><Services><Smoke><Smoking><Smoking Cessation Intervention><Stigma around HIV><Stigma in HIV><Stigma related to HIV><Strategic Planning><Stress><Study Type><Survey Instrument><Surveys><Technology><Testing><Tobacco Consumption><Tobacco Use Disorder><Tobacco use><Uncertainty><United States National Institutes of Health><Virus-HIV><Voice><Work><anti-retroviral><arm><assess effectiveness><cancer diagnosis><cancer disparity><cancer health disparity><cancer-related health disparity><cease smoking><clinical practice and guidelines><cognitive defects><community advisory board><community advisory committee><community advisory panel><compare effectiveness><cost><craving><cross sectional prevalence><design><designing><determine effectiveness><developmental><digital app><digital applications><digital intervention><digital therapeutics><digital therapy><digital treatment><disparity in cancer><doubt><e-cig><e-cigarette><ecig><ecigarette><effective therapy><effective treatment><effectiveness and implementation trial><effectiveness assessment><effectiveness evaluation><effectiveness/implementation hybrid trial><effectiveness/implementation trial><evaluate effectiveness><evaluate implementation><evaluation of implementation><evidence base><examine effectiveness><experience><facilitators to implementation><health care personnel><health care worker><health equity><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><human immunodeficiency virus infection><human immunodeficiency virus research><implementation evaluation><implementation facilitators><implementation science><implementation strategy><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><interest><intervention design><lung cancer><malignancy><medical care providers><medical personnel><mortality><multidisciplinary><neoplasm/cancer><nicotine replacement><novel><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><pilot study><pilot trial><point prevalence><population based intervention><population specific intervention><prevent><preventing><primary outcome><quit smoking><randomized control trial><recruit><research addressing HIV><research in HIV><research into HIV><research into practice><research on HIV><research on human immunodeficiency virus><research to address HIV><research to practice><science on HIV><science to address HIV><secondary outcome><smoking cessation><smoking cessation treatment><smoking prevalence><smoking-related cancer><social><stigma associated with HIV><stop smoking><strategies for implementation><studies on HIV><study design><substance use><substance using><therapeutic biomarker><therapeutic marker><therapy adherence><therapy compliance><therapy design><tobacco disorder><tobacco product use><treat HIV><treat Human Immunodeficiency Virus><treatment design><treatment effect><treatment provider><user centered design>
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Roger Vilardaga

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$621,825
FY 2026

Project Title

Hybrid Trial of a Tailored Smoking Cessation Digital Therapeutic for Persons Living with HIV

Grant Number:

5R01CA285331-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/9/2024

End Date:

1/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT Tobacco use has alarmingly high rates among people with HIV (PWH), 43% compared with 15% in the general population. Due to the development of highly effective treatments for HIV and the resulting increased longevity among PWH, this population now loses more life years to smoking tha...

Research Terms

<AIDS Virus><AIDS focused research><AIDS related research><AIDS related stigma><AIDS research><AIDS science><AIDS specific research><AIDS stigma><Abstinence><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adherence><African American><Afro American><Afroamerican><Anti-Retroviral Agents><Area><Assess implementation><Behavioral><Biochemical><Cancer Control><Cancer Control Science><Cancers><Cigarette><Clinic><Clinical><Clinical Practice Guideline><Clinical effectiveness><Cognitive deficits><Communities><Confidence Intervals><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Control Groups><Data><Development><Disease><Disorder><Effectiveness><Electronic cigarette><Future><General Population><General Public><Guidelines><HIV><HIV Infections><HIV associated stigma><HIV focused research><HIV individuals><HIV infected individuals><HIV infected persons><HIV internalized stigma><HIV intervention><HIV investigation><HIV people><HIV positive individuals><HIV positive people><HIV related research><HIV related stigma><HIV research><HIV science><HIV specific research><HIV stigma><HIV therapeutic><HIV therapy><HIV treatment><HIV viral infection><HIV virus infection><HIV-1 infection><HIV-1 intervention><HIV-1 therapeutic><HIV-1 therapy><HIV-1 treatment><HIV-based discrimination><HIV-related discrimination><HIV-related social stigma><HIV/AIDS stigma><Health><Health Care Providers><Health Personnel><Human Immunodeficiency Virus therapy><Human Immunodeficiency Virus treatment><Human Immunodeficiency Viruses><Hybrids><Implementation assessment><Improve Access><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Intervention><Interview><Investigation on HIV><LAV-HTLV-III><Learning><Length of Life><Life><Longevity><Lymphadenopathy-Associated Virus><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Measures><Mental Health><Mental Hygiene><Methodology><Methods><Modeling><Morbidity><NCI Organization><NIH><National Cancer Institute><National Institutes of Health><Nicotine Replacement Therapy><Outcome><PLWH><PWH><Patient Self-Report><Patients><Persons><Phase><Pilot Projects><Play><Population><Population Intervention><Psychological Health><Public Health><Pulmonary Cancer><Pulmonary malignant Neoplasm><QOL><Quality of life><Randomized, Controlled Trials><Recommendation><Reporting><Research><Research Design><Research Priority><Sampling><Secure><Self-Report><Services><Smoke><Smoking><Smoking Cessation Intervention><Stigma around HIV><Stigma in HIV><Stigma related to HIV><Strategic Planning><Stress><Study Type><Survey Instrument><Surveys><Technology><Testing><Tobacco Consumption><Tobacco Use Disorder><Tobacco use><Uncertainty><United States National Institutes of Health><Virus-HIV><Voice><Work><anti-retroviral><arm><assess effectiveness><cancer diagnosis><cancer disparity><cancer health disparity><cancer-related health disparity><cease smoking><clinical practice and guidelines><cognitive defects><community advisory board><community advisory committee><community advisory panel><compare effectiveness><cost><craving><cross sectional prevalence><design><designing><determine effectiveness><developmental><digital app><digital applications><digital intervention><digital therapeutics><digital therapy><digital treatment><disparity in cancer><doubt><e-cig><e-cigarette><ecig><ecigarette><effective therapy><effective treatment><effectiveness and implementation trial><effectiveness assessment><effectiveness evaluation><effectiveness/implementation hybrid trial><effectiveness/implementation trial><evaluate effectiveness><evaluate implementation><evaluation of implementation><evidence base><examine effectiveness><experience><facilitators to implementation><health care personnel><health care worker><health equity><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><human immunodeficiency virus infection><human immunodeficiency virus research><implementation evaluation><implementation facilitators><implementation science><implementation strategy><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><interest><intervention design><lung cancer><malignancy><medical care providers><medical personnel><mortality><multidisciplinary><neoplasm/cancer><nicotine replacement><novel><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><pilot study><pilot trial><point prevalence><population based intervention><population specific intervention><prevent><preventing><primary outcome><quit smoking><randomized control trial><recruit><research addressing HIV><research in HIV><research into HIV><research into practice><research on HIV><research on human immunodeficiency virus><research to address HIV><research to practice><science on HIV><science to address HIV><secondary outcome><smoking cessation><smoking cessation treatment><smoking prevalence><smoking-related cancer><social><stigma associated with HIV><stop smoking><strategies for implementation><studies on HIV><study design><substance use><substance using><therapeutic biomarker><therapeutic marker><therapy adherence><therapy compliance><therapy design><tobacco disorder><tobacco product use><treat HIV><treat Human Immunodeficiency Virus><treatment design><treatment effect><treatment provider><user centered design>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

DOUGLAS R SEALS

UNIVERSITY OF COLORADO, Boulder, CO

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$580,586
FY 2026

Project Title

Inspiratory muscle strength training for lowering blood pressure and improving endothelial function in postmenopausal women: comparison with "standard of care" aerobic exercise

Grant Number:

5R01AG071506-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2021

End Date:

2/28/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY High blood pressure (BP), particularly systolic BP (SBP), is the major modifiable risk factor for cardiovascular diseases and related disorders of aging. SBP increases markedly with aging in women such that the prevalence of above-normal SBP (i.e., ≥120 mmHg) in postmenopausal (PM) ...

Research Terms

<21+ years old><Active Oxygen><Acute><Adherence><Adult><Adult Human><Aerobic Activity><Aerobic Exercise><Aerobic Training><Aerobic fitness><Age><Aging><Antioxidants><Ascorbic Acid><Back><Bioavailability><Biological Availability><Biopsy><Blood Plasma><Blood Pressure><Blood Serum><Cardiovascular Diseases><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Clinical Trials><Diastolic Pressure><Diastolic blood pressure><Disease><Disorder><Dorsum><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Dropout><Endogenous Nitrate Vasodilator><Endothelial Cells><Endothelium><Endothelium-Derived Nitric Oxide><Estrogen deficiency><Exhibits><Facility Accesses><Funding><Guidelines><Health><Home><Hour><Human><Hypertension><Infusion><Infusion procedures><Inhalation><Inhaling><Intracellular Communication and Signaling><Lifestyle Therapy><Link><Measures><Mediating><Modern Man><Molecular><Mononitrogen Monoxide><Nitric Oxide><Nitrogen Monoxide><Nitrogen Protoxide><Oxidative Stress><Oxidative Stress Induction><Oxygen Radicals><Physiologic Availability><Pilot Projects><Plasma><Plasma Serum><Post-Menopause><Post-menopausal Period><Postmenopausal Period><Postmenopause><Pre-Menopause><Pre-menopausal Period><Premenopausal><Premenopausal Period><Premenopause><Prevalence><Pro-Oxidants><Process><Production><Public Health><Randomized><Reactive Oxygen Species><Resistance><Rest><Reticuloendothelial System, Serum, Plasma><Risk><Role><Safety><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Time><Training><Translating><Travel><Treatment Period><Umbilical vein><VIT C><Vascular Endothelium><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Vitamin C><Walking><Woman><adulthood><after menopause><ages><aging associated disease><aging associated disorders><aging related disease><aging related disorders><biological signal transduction><blood pressure elevation><brachial artery><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cardiovascular health><cardiovascular risk><cardiovascular risk factor><cell culture><cell cultures><chronic kidney disease><clinical practice><clinical relevance><clinically relevant><comparable efficacy><comparative efficacy><compare efficacy><deficiency in estrogen><design><designing><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><effective intervention><elevated blood pressure><endothelial cell derived relaxing factor><evidence base><exercise program><exercise training><fitness program><following menopause><handheld device><handheld equipment><health goals><high blood pressure><homes><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><in vivo><increase in blood pressure><increased blood pressure><infusions><insight><life style intervention><lifestyle intervention><malleable risk><men><metabolism measurement><metabolomics><metabonomics><mid life><mid-life><middle age><middle aged><midlife><modifiable risk><molecular biomarker><molecular marker><muscle strength><muscle strengthening><novel><older adult><older adulthood><older men><older women><past menopause><pilot study><pilot trial><portability><post intervention><post-menopausal><postmenopausal><postmenopausal status><pre-menopausal><premenopausal status><pressure><primary outcome><randomisation><randomization><randomized, clinical trials><randomly assigned><resistant><secondary outcome><social role><standard of care><strength training><treatment days><treatment duration><vascular endothelial dysfunction>
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TAMILYN BAKAS

UNIVERSITY OF CINCINNATI, CINCINNATI, OH

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$528,362
FY 2026

Project Title

Telehealth Assessment and Skill-Building Intervention for Stroke Caregivers (TASK III)

Grant Number:

5R01NR020184-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/12/2022

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract: Stroke is a leading cause of serious, long-term disability, and has a very sudden onset. Families are often thrust into providing care without sufficient training from health care providers, having to learn on their own to provide care. Studies show that caregiving without ...

Research Terms

<Address><American><American Heart Association><Apoplexy><Brain Vascular Accident><Care Givers><Care giver intervention><Caregivers><Caring><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chronic><Climacteric><Clinical Trials><Communication><Data><E-book><Ebook><Education><Educational aspects><Emotional><Emotional Depression><Emotional well being><Enrollment><Family><Family Care Giver><Family Caregiver><Family member><Fatigue><Feasibility Studies><Feels well><Funding><Future><Goals><Guidelines><Health><Health Care><Health Care Providers><Health Care Technology><Health Care Utilization><Health Personnel><Health Technology><Institutionalization><Intervention><Lack of Energy><Learning><Long-term disability><Managed Care><Mediator><Medical Rehabilitation><Mental Health><Mental Hygiene><Normal mental condition><Normal mental state><Normal psyche><Nurses><Outcome><Pain><Painful><Patient Self-Report><Patients><Perception><Phone><Physical Function><Policies><Problem Solving><Program Evaluation><Psychological Health><Psychological Well Being><Public Health><Publishing><Randomized><Randomized Controlled Clinical Trials><Recommendation><Rehabilitation><Rehabilitation therapy><Reporting><Risk><Self Efficacy><Self Management><Self-Report><Sense of well-being><Shortness of Breath><Sleep><Stress><Stressful Event><Stroke><Survivors><Symptoms><Technology><Telephone><Testing><Time><Time Management><Training><Translating><Videoconferencing><Well in self><brain attack><care giving><care services><care systems><caregiver interventions><caregiving><cerebral vascular accident><cerebrovascular accident><cost><depression symptom><depressive><depressive symptoms><diet and exercise><directed attention><directs attention><disability><efficacy testing><electronic book><emotional wellbeing><emotional wellness><empowerment><enroll><expectation><experience><health assessment><health care personnel><health care service use><health care service utilization><health care worker><health provider><health staff><health training><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><improved><innovate><innovation><innovative><intervention program><life change><medical care providers><medical personnel><mental well-being><mental wellbeing><mental wellness><novel><nurse><physical conditioning><physical health><post intervention><preference><premature><prematurity><primary outcome><programs><psychoeducation><psychological wellbeing><psychological wellness><randomisation><randomization><randomized control clinical trial><randomly assigned><recruit><rehab therapy><rehabilitative><rehabilitative therapy><resource guides><satisfaction><secondary outcome><self wellness><sense of wellbeing><skills><societal costs><stress buffering><stress management><stressful experience><stressful life event><stressful life experience><stroke intervention><stroke survivor><stroked><strokes><symptom self management><telehealth><treatment provider><trend><video conferencing><web site><website>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Bruno T Roseguini

PURDUE UNIVERSITY, WEST LAFAYETTE, IN

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$427,586
FY 2026

Project Title

Leg heat therapy to improve functional performance in peripheral artery disease

Grant Number:

5R01AG073634-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2022

End Date:

4/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Lower-extremity peripheral artery disease (PAD) is a manifestation of systemic atherosclerosis that affects more than 236 million individuals worldwide. Patients with PAD have a worse quality of life (QOL) than their healthy counterparts, due in part to the marked decline in physical...

Research Terms

<ASCVD><Abnormal gait><Acceleration><Aching muscles><Active Follow-up><Activities of Daily Living><Activities of everyday life><Address><Affect><American><Angiogenesis Factor><Angiogenic Factor><Area><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Atrophic><Atrophy><Bathing><Baths><Biological><Biopsy><Biopsy Sample><Biopsy Specimen><Blood capillaries><Blood flow><Body Tissues><Buttocks><Capillarity><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Clinical><Controlled Clinical Trials><Coupled><Custom><Data><Diagnosis><Doctor of Philosophy><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Engineering><Equilibrium><Event><Exercise routine><Exposure to><Fats><Fatty acid glycerol esters><Foundations><Gait abnormality><Gait disorder><Gait disturbances><Gait dysfunction><Gait impairment><Generalized Growth><Goals><Growth><Heart Vascular><Heating><Home><Human><Hydrogen Oxide><Immersion><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Individual><Infiltration><Intervention><Ischemia><Isokinetic Exercise><Isokinetics><Isotonic Exercise><Isotonics><Leg><Link><Lower Extremity><Lower Limb><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Membrum inferius><Modeling><Modern Man><Morphology><Muscle><Muscle Atrophy><Muscle Fatigue><Muscle Tissue><Muscle discomfort><Muscle pain><Muscle pain/fibrositis><Muscle sorenesss><Muscular Atrophy><Muscular Fatigue><Myalgia><Myalgic><Myodynia><Myoneuralgia><Myosalgia><NMR Imaging><NMR Tomography><National Institute of Aging><National Institute on Aging><Nuclear Magnetic Resonance Imaging><Outcome Study><Pain><Painful><Painless><Participant><Pathway interactions><Patient Compliance><Patients><Perceived quality of life><Performance><Perfusion><Peripheral arterial disease><Persons><Ph.D.><PhD><Physical Function><Physical Performance><Pilot Projects><Pre-Clinical Model><Preclinical Models><Pump><QOL><QOL improvement><Quality of life><Randomized><Recovery><Reporting><Research><Resistance><Safety><Skeletal Muscle><Supervision><System><Therapeutic><Therapeutic Heat><Therapeutic heat application><Therapy trial><Thigh><Thigh structure><Tissue Growth><Tissues><Translating><Translations><Voluntary Muscle><Walking><Walking impairment><Water><Work><Zeugmatography><active followup><arterial spin labeling><arterial spin tagging><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><balance><balance function><biologic><capillary><circulatory system><clinical practice><combat><customs><daily living function><daily living functionality><decline in function><decline in functional status><diet-associated obesity><diet-induced obesity><diet-related obesity><elderly patient><evidence base><exercise intolerance><exercise regimen><experiment><experimental research><experimental study><experiments><follow up><follow-up><followed up><followup><functional ability><functional capacity><functional decline><functional disability><functional restoration><functional status decline><heat therapy><homes><improved><improvements in QOL><improvements in quality of life><meter><mortality><muscle breakdown><muscle bulk><muscle degradation><muscle deterioration><muscle form><muscle loss><muscle mass><muscle strength><muscle wasting><muscular><new approaches><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><non-painful><nonpainful><not painful><novel><novel approaches><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><older patient><ontogeny><pathway><patient adherence><patient cooperation><performance in walking><peripheral artery disease><pilot study><pilot trial><placebo group><portability><quality of life improvement><randomisation><randomization><randomized, clinical trials><randomly assigned><resistant><restore function><restore functionality><restore lost function><secondary outcome><sedentary><sham group><tool><translation><walking pace><walking performance><walking speed>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Susan E Brockerhoff

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$410,551
FY 2026

Project Title

IMPDH1 in photoreceptor function and disease

Grant Number:

5R01EY033731-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Although purine nucleotide homeostasis is critical to photoreceptor health, basic aspects of purine metabo- lism and its regulation in photoreceptors are unknown. Here, we analyze the critical role of inosine monophos- phate dehydrogenase 1 (IMDPH1) in retinal function and disease. I...

Research Terms

<5'-Inosinic acid><Adenine Nucleotides><Adenosine Phosphates><Allosteric Regulation><Anabolism><Animals><Antibody Specificity><Assay><Autoregulation><Bioassay><Biochemical><Biochemistry><Biologic Models><Biological><Biological Assay><Biological Chemistry><Biological Models><Blindness><Body Tissues><Brachydanio rerio><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular biology><Collection><Cone Photoreceptors><Cryo-electron Microscopy><Cryoelectron Microscopy><DNA Binding><DNA Binding Interaction><DNA bound><DNA mutation><Danio rerio><Data><Degenerative Disorder><Dehydrogenases><Deterioration><Disease><Disorder><Dissection><Electron Cryomicroscopy><Energy Expenditure><Energy Metabolism><Engineering><Enzyme Gene><Enzyme Inhibition><Enzymes><Equilibrium><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Eye><Eyeball><Filament><Gene Transcription><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Guanine Nucleotides><Guanosine Phosphates><Health><Hereditary><Hereditary Disease><Homeostasis><Human><Immune Precipitation><Immunofluorescence><Immunofluorescence Immunologic><Immunoprecipitation><In Situ><In Vitro><Inborn Genetic Diseases><Inherited><Inherited disorder><Inosine Monophosphate><Intermediary Metabolism><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Light><Link><Metabolic><Metabolic Processes><Metabolism><Methods><Missense Mutation><Mitochondria><Mitochondrial DNA><Model System><Modeling><Modern Man><Molecular><Mutation><Non-Polyadenylated RNA><Nucleotide Biosynthesis><Nucleotide Synthesis><Nucleotides><Null Mouse><Oxidoreductase><Oxidoreductase Gene><Pathway interactions><Patients><Phenotype><Photoradiation><Photoreceptor Cell><Photoreceptors><Photosensitive Cell><Physiologic><Physiological><Physiological Homeostasis><Polymers><Position><Positioning Attribute><Property><Proteins><Purine Metabolism Pathway><Purine Nucleotides><Purines><Purines/Pyrimidines/Nucleotides/Nucleic Acids Metabolism><R21 Award><RNA><RNA Expression><RNA Gene Products><RalDH1><Reagent><Reductases><Regulation><Reporter><Resolution><Retina><Retinal Cone><Retinal Degeneration><Retinal Diseases><Retinal Disorder><Retinal Dystrophy><Ribonucleic Acid><Ribosylhypoxanthine Monophosphate><Rods and Cones><Role><Signaling Molecule><Single-Stranded DNA><Structure><Subcellular Process><Tissues><Transcription><Transgenic Organisms><Translations><Variant><Variation><Vertebrate Photoreceptors><Visual Receptor><Zebra Danio><Zebra Fish><Zebrafish><autosomal dominant mutation><balance><balance function><biologic><biosynthesis><blind><cell biology><cell type><circadian><cone cell><cryo-EM><cryoEM><cryogenic electron microscopy><degenerative condition><degenerative disease><degenerative retina diseases><disease model><disorder model><energy balance><enzyme activity><gain of function><genome mutation><hereditary disorder><heritable disorder><human disease><in vivo><inborn error><inherited diseases><inherited genetic disease><inherited genetic disorder><interdisciplinary approach><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><mitochondrial><mtDNA><multidisciplinary approach><mutant><nucleotide metabolism><pathway><photoreceptor degeneration><polymer><polymeric><protein expression><purine metabolism><resolutions><retina degeneration><retina disease><retina disorder><retinal degenerative><retinal degenerative diseases><retinal dehydrogenase 1><retinopathy><social role><ssDNA><structural biology><tool><transgenic><translation><vision loss><visual loss>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Justin M Kollman

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$410,551
FY 2026

Project Title

IMPDH1 in photoreceptor function and disease

Grant Number:

5R01EY033731-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Although purine nucleotide homeostasis is critical to photoreceptor health, basic aspects of purine metabo- lism and its regulation in photoreceptors are unknown. Here, we analyze the critical role of inosine monophos- phate dehydrogenase 1 (IMDPH1) in retinal function and disease. I...

Research Terms

<5'-Inosinic acid><Adenine Nucleotides><Adenosine Phosphates><Allosteric Regulation><Anabolism><Animals><Antibody Specificity><Assay><Autoregulation><Bioassay><Biochemical><Biochemistry><Biologic Models><Biological><Biological Assay><Biological Chemistry><Biological Models><Blindness><Body Tissues><Brachydanio rerio><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular biology><Collection><Cone Photoreceptors><Cryo-electron Microscopy><Cryoelectron Microscopy><DNA Binding><DNA Binding Interaction><DNA bound><DNA mutation><Danio rerio><Data><Degenerative Disorder><Dehydrogenases><Deterioration><Disease><Disorder><Dissection><Electron Cryomicroscopy><Energy Expenditure><Energy Metabolism><Engineering><Enzyme Gene><Enzyme Inhibition><Enzymes><Equilibrium><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Eye><Eyeball><Filament><Gene Transcription><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genome><Guanine Nucleotides><Guanosine Phosphates><Health><Hereditary><Hereditary Disease><Homeostasis><Human><Immune Precipitation><Immunofluorescence><Immunofluorescence Immunologic><Immunoprecipitation><In Situ><In Vitro><Inborn Genetic Diseases><Inherited><Inherited disorder><Inosine Monophosphate><Intermediary Metabolism><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><Light><Link><Metabolic><Metabolic Processes><Metabolism><Methods><Missense Mutation><Mitochondria><Mitochondrial DNA><Model System><Modeling><Modern Man><Molecular><Mutation><Non-Polyadenylated RNA><Nucleotide Biosynthesis><Nucleotide Synthesis><Nucleotides><Null Mouse><Oxidoreductase><Oxidoreductase Gene><Pathway interactions><Patients><Phenotype><Photoradiation><Photoreceptor Cell><Photoreceptors><Photosensitive Cell><Physiologic><Physiological><Physiological Homeostasis><Polymers><Position><Positioning Attribute><Property><Proteins><Purine Metabolism Pathway><Purine Nucleotides><Purines><Purines/Pyrimidines/Nucleotides/Nucleic Acids Metabolism><R21 Award><RNA><RNA Expression><RNA Gene Products><RalDH1><Reagent><Reductases><Regulation><Reporter><Resolution><Retina><Retinal Cone><Retinal Degeneration><Retinal Diseases><Retinal Disorder><Retinal Dystrophy><Ribonucleic Acid><Ribosylhypoxanthine Monophosphate><Rods and Cones><Role><Signaling Molecule><Single-Stranded DNA><Structure><Subcellular Process><Tissues><Transcription><Transgenic Organisms><Translations><Variant><Variation><Vertebrate Photoreceptors><Visual Receptor><Zebra Danio><Zebra Fish><Zebrafish><autosomal dominant mutation><balance><balance function><biologic><biosynthesis><blind><cell biology><cell type><circadian><cone cell><cryo-EM><cryoEM><cryogenic electron microscopy><degenerative condition><degenerative disease><degenerative retina diseases><disease model><disorder model><energy balance><enzyme activity><gain of function><genome mutation><hereditary disorder><heritable disorder><human disease><in vivo><inborn error><inherited diseases><inherited genetic disease><inherited genetic disorder><interdisciplinary approach><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><mitochondrial><mtDNA><multidisciplinary approach><mutant><nucleotide metabolism><pathway><photoreceptor degeneration><polymer><polymeric><protein expression><purine metabolism><resolutions><retina degeneration><retina disease><retina disorder><retinal degenerative><retinal degenerative diseases><retinal dehydrogenase 1><retinopathy><social role><ssDNA><structural biology><tool><transgenic><translation><vision loss><visual loss>
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Nurit Ballas

STATE UNIVERSITY NEW YORK STONY BROOK, STONY BROOK, NY

Good lead · 66/100
Likely hiring
Solid budget
Very recent
Active award
$398,750
FY 2026

Project Title

Investigating mitochondrial dysfunction in human astrocytes with RTT-causing MECP2 mutations

Grant Number:

5R01NS136519-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/5/2024

End Date:

4/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary Mutations in the X-linked gene, methyl-CpG binding protein 2 (MECP2), underlie a wide range of neuropsychiatric disorders, most commonly Rett syndrome (RTT), a severe neurodevelopmental disorder. Despite numerous studies, why the loss of MeCP2 function results in RTT remains largely obscure,...

Research Terms

<Acceleration><Affect><Assay><Astrocytes><Astrocytus><Astroglia><Autoregulation><Bioassay><Biological><Biological Assay><Brain><Brain Nervous System><CUT&RUN><Cell Aging><Cell Senescence><Cell Senescence Induction><Cellular Aging><Cellular Senescence><Cerebroatrophic Hyperammonemia><Characteristics><Chromatin><Citric Acid Cycle><Cleavage Targets and Release Using Nuclease><Cleavage Under Targets and Release Using Nuclease><DNA mutation><Data><Defect><Development><Disease><Disorder><Encephalon><Energy Expenditure><Energy Metabolism><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Transcription><Genes><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Glia><Glial Cells><Glutamates><Homeostasis><Human><Hypoxia><Hypoxic><Impairment><Knowledge><Kolliker's reticulum><Krebs Cycle><L-Glutamate><Link><MeCP-2 protein><MeCP2><MeCP2 protein><Mediating><Metabolic><Methyl CpG binding protein MeCP2><Methyl-CpG-Binding Protein 2><Methyl-DNA binding protein MECP2><Mice><Mice Mammals><Mitochondria><Modeling><Modern Man><Molecular><Morphology><Murine><Mus><Mutation><NIH><National Institutes of Health><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Nervous System Physiology><Neural Cell><Neurocyte><Neurodevelopmental Disorder><Neuroglia><Neuroglial Cells><Neurologic Disorders><Neurologic function><Neurological Development Disorder><Neurological Disorders><Neurological function><Neuronal Dysfunction><Neurons><Non-neuronal cell><Nonneuronal cell><Oxidative Stress><Oxygen Consumption><Oxygen Deficiency><Pathway interactions><Patients><Phenotype><Physiological Homeostasis><Physiology><Predisposition><Property><Pyruvate><R21 Award><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Replicative Senescence><Rett Disorder><Rett Syndrome><Role><Structure><Susceptibility><TCA cycle><Therapeutic><Therapeutic Intervention><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Tricarboxylic Acid Cycle><United States National Institutes of Health><analyze gene expression><astrocytic glia><biologic><cell type><cellular aging induction><cellular senescence induction><developmental><differential expression><differentially expressed><gene expression analysis><gene expression assay><genome mutation><glutamatergic><human derived model><human derived platform><human derived system><human like model><human like platform><human like system><human progenitor><human specific alternative><human specific model><human specific platform><human specific system><human stem cells><human-based alternative><human-based biological models><human-based model><human-based nonanimal models><human-based platform><human-based research><human-based system><human-based tools><human-centered model><human-centered platform><human-centered research><human-centered system><human-focused research><human-relevant alternative><human-relevant model><human-relevant platform><human-relevant system><iPS><iPSC><iPSCs><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><inhibitor><intervention therapy><mitochondrial><mitochondrial dysfunction><mitochondrial metabolism><mouse model><murine model><mutant><nerve cement><nervous system function><neural dysfunction><neurodevelopmental disease><neurological disease><neuronal><neuropathologic><neuropathological><neuropathology><neuropsychiatric disease><neuropsychiatric disorder><pathway><progenitor cell model><progenitor model><replicative aging><restoration><senescence><senescence induction><senescent><senescent cell><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic development><transcriptional differences><transcriptional profiling><transcriptome sequencing><transcriptomic sequencing><uptake>
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Susan Louise Baldwin

SEATTLE CHILDREN'S HOSPITAL, SEATTLE, WA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$994,034
FY 2026

Project Title

Targeted vaccines against pulmonary NTM infections in vulnerable populations

Grant Number:

5R01AI183642-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/20/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

NTM infections have now surpassed tuberculosis in the U.S. and are a global concern. Long (>12 months) treatment regimens and severe toxic side effects of drug treatment warrant urgent development of new strategies. We hypothesize that a vaccine targeted against pathogenic NTM will improve immunity ...

Research Terms

<(TNF)-α><Adjuvant><Adoptive Transfer><Aerosols><Amikacin><Amikin><Amiklin><Amukin><Animals><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-Tumor Necrosis Factor Therapy><Anti-inflammatory><Antigens><Arthritis><Assay><Atrophic Arthritis><Bacteria><Biclin><Biklin><Bioassay><Biological Assay><C3HeB/FeJ Mouse><COPD><Cachectin><Cell Body><Cells><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clinical Treatment Moab><Complex><Development><Disease><Disorder><Drug Side Effects><Drug Therapy><Effectiveness><Elderly><Evaluation><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Female><Funding><Generalized Growth><Genetic><Goals><Growth><Human><Immune><Immunes><Immunity><Immunization><Incidence><Individual><Infection><Infectious disease threat><Inflammatory><KO mice><Knock-out Mice><Knockout Mice><Lead><Lipids><Liver><Lung><Lung Diseases><Lung Respiratory System><M abscessus><M avium><M avium Complex><M tuberculosis infection><M. abscessus><M. avium><M. avium Complex><M. avium intracellulare><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MAIC><MTB infection><Macrophage-Derived TNF><Medical><Mice><Mice Mammals><Modeling><Modern Man><Monoclonal Antibodies><Monocyte-Derived TNF><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Mycobacterial Infection><Mycobacterium Infections><Mycobacterium abscessus><Mycobacterium avium><Mycobacterium avium Complex><Mycobacterium avium-intracellulare><Mycobacterium avium-intracellulare Complex><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Mycobacteroides abscessus><Non-Polyadenylated RNA><Null Mouse><Outcome><Paper><Pathogenicity><Pathogenicity Factors><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Persons><Pharmacological Treatment><Pharmacotherapy><Phase><Phase 2 Clinical Trials><Phase II Clinical Trials><Population><Prevalence><Prevention><Proteins><Publishing><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Pathology><QOL improvement><R21 Award><RNA><RNA Gene Products><RNA vaccine><RNA-based vaccine><Regimen><Replication Unit><Replicon><Research><Rheumatoid Arthritis><Ribonucleic Acid><Risk><Route><Selection Criteria><Sequence Homology><Site><Spleen><Spleen Reticuloendothelial System><Subunit Vaccines><TB infection><TNF><TNF A><TNF Alpha><TNF gene><TNF therapy><TNF-α><TNFA><TNFα><Target Populations><Testing><Therapeutic><Therapeutic Uses><Tissue Growth><Treatment Efficacy><Treatment Protocols><Treatment Regimen><Treatment Schedule><Tuberculosis><Tumor Necrosis Factor><Tumor Necrosis Factor Therapy><Tumor Necrosis Factor-alpha><Vaccine Antigen><Vaccines><Virulence Factors><Virulent><Vulnerable Populations><Woman><Work><advanced age><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><aging population><anti-TNF therapy><anti-TNF-alpha therapy><arthritic><biological sex as a modifier><chronic obstructive pulmonary disorder><clinical candidate><clinical relevance><clinically relevant><design><designing><determine efficacy><develop a vaccine><develop vaccines><development of a vaccine><developmental><disease of the lung><disease prevention><disorder of the lung><disorder prevention><disseminated TB><disseminated tuberculosis><drug intervention><drug treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy study><efficacy testing><elderly mice><evaluate efficacy><evaluate vaccines><examine efficacy><experiment><experimental research><experimental study><experiments><geriatric><heavy metal Pb><heavy metal lead><hepatic body system><hepatic organ system><high risk><high risk group><high risk individual><high risk people><high risk population><immune senescence><immunogen><immunogenicity><immunosenescence><improved><improvements in QOL><improvements in quality of life><in vivo><infection due to Mycobacterium tuberculosis><innovate><innovation><innovative><intervention efficacy><intravenous injection><lung disorder><lung histology><lung pathology><mAbs><mRNA vaccine><mRNA-based vaccine><male><men><monoclonal Abs><mouse model><murine model><mycobacterial><nano particle><nano-sized particle><nanoparticle><nanosized particle><non-tuberculosis mycobacteria><non-tuberculosis mycobacterial><non-tuberculous mycobacteria><non-tuberculous mycobacterial><nontuberculosis mycobacterial><nontuberculous mycobacteria><nontuberculous mycobacterial><novel><old mice><ontogeny><patient oriented outcomes><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phase II protocol><population aging><pre-clinical efficacy><preclinical efficacy><prevent><preventing><prophylactic><prototype><pulmonary><pulmonary histology><quality of life improvement><replicon vaccine><rheumatic arthritis><senior citizen><sex as a biological factor><sex as a biological measure><sex as a biological risk factor><sex as a biological variable><sex as a biological variance><sex as a biologically significant variable><sex as a fundamental variable><side effect><therapeutic efficacy><therapy efficacy><tuberculosis infection><tuberculous spondyloarthropathy><vaccine candidate><vaccine development><vaccine efficacy><vaccine evaluation><vaccine screening><vaccine testing><vulnerable group><vulnerable individual><vulnerable people><♀><♂>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Rhea N Coler

SEATTLE CHILDREN'S HOSPITAL, SEATTLE, WA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$994,034
FY 2026

Project Title

Targeted vaccines against pulmonary NTM infections in vulnerable populations

Grant Number:

5R01AI183642-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/20/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

NTM infections have now surpassed tuberculosis in the U.S. and are a global concern. Long (>12 months) treatment regimens and severe toxic side effects of drug treatment warrant urgent development of new strategies. We hypothesize that a vaccine targeted against pathogenic NTM will improve immunity ...

Research Terms

<(TNF)-α><Adjuvant><Adoptive Transfer><Aerosols><Amikacin><Amikin><Amiklin><Amukin><Animals><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-Tumor Necrosis Factor Therapy><Anti-inflammatory><Antigens><Arthritis><Assay><Atrophic Arthritis><Bacteria><Biclin><Biklin><Bioassay><Biological Assay><C3HeB/FeJ Mouse><COPD><Cachectin><Cell Body><Cells><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clinical Treatment Moab><Complex><Development><Disease><Disorder><Drug Side Effects><Drug Therapy><Effectiveness><Elderly><Evaluation><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Female><Funding><Generalized Growth><Genetic><Goals><Growth><Human><Immune><Immunes><Immunity><Immunization><Incidence><Individual><Infection><Infectious disease threat><Inflammatory><KO mice><Knock-out Mice><Knockout Mice><Lead><Lipids><Liver><Lung><Lung Diseases><Lung Respiratory System><M abscessus><M avium><M avium Complex><M tuberculosis infection><M. abscessus><M. avium><M. avium Complex><M. avium intracellulare><M. tb infection><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MAIC><MTB infection><Macrophage-Derived TNF><Medical><Mice><Mice Mammals><Modeling><Modern Man><Monoclonal Antibodies><Monocyte-Derived TNF><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Mycobacterial Infection><Mycobacterium Infections><Mycobacterium abscessus><Mycobacterium avium><Mycobacterium avium Complex><Mycobacterium avium-intracellulare><Mycobacterium avium-intracellulare Complex><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Mycobacteroides abscessus><Non-Polyadenylated RNA><Null Mouse><Outcome><Paper><Pathogenicity><Pathogenicity Factors><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Persons><Pharmacological Treatment><Pharmacotherapy><Phase><Phase 2 Clinical Trials><Phase II Clinical Trials><Population><Prevalence><Prevention><Proteins><Publishing><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Pathology><QOL improvement><R21 Award><RNA><RNA Gene Products><RNA vaccine><RNA-based vaccine><Regimen><Replication Unit><Replicon><Research><Rheumatoid Arthritis><Ribonucleic Acid><Risk><Route><Selection Criteria><Sequence Homology><Site><Spleen><Spleen Reticuloendothelial System><Subunit Vaccines><TB infection><TNF><TNF A><TNF Alpha><TNF gene><TNF therapy><TNF-α><TNFA><TNFα><Target Populations><Testing><Therapeutic><Therapeutic Uses><Tissue Growth><Treatment Efficacy><Treatment Protocols><Treatment Regimen><Treatment Schedule><Tuberculosis><Tumor Necrosis Factor><Tumor Necrosis Factor Therapy><Tumor Necrosis Factor-alpha><Vaccine Antigen><Vaccines><Virulence Factors><Virulent><Vulnerable Populations><Woman><Work><advanced age><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><aging population><anti-TNF therapy><anti-TNF-alpha therapy><arthritic><biological sex as a modifier><chronic obstructive pulmonary disorder><clinical candidate><clinical relevance><clinically relevant><design><designing><determine efficacy><develop a vaccine><develop vaccines><development of a vaccine><developmental><disease of the lung><disease prevention><disorder of the lung><disorder prevention><disseminated TB><disseminated tuberculosis><drug intervention><drug treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy study><efficacy testing><elderly mice><evaluate efficacy><evaluate vaccines><examine efficacy><experiment><experimental research><experimental study><experiments><geriatric><heavy metal Pb><heavy metal lead><hepatic body system><hepatic organ system><high risk><high risk group><high risk individual><high risk people><high risk population><immune senescence><immunogen><immunogenicity><immunosenescence><improved><improvements in QOL><improvements in quality of life><in vivo><infection due to Mycobacterium tuberculosis><innovate><innovation><innovative><intervention efficacy><intravenous injection><lung disorder><lung histology><lung pathology><mAbs><mRNA vaccine><mRNA-based vaccine><male><men><monoclonal Abs><mouse model><murine model><mycobacterial><nano particle><nano-sized particle><nanoparticle><nanosized particle><non-tuberculosis mycobacteria><non-tuberculosis mycobacterial><non-tuberculous mycobacteria><non-tuberculous mycobacterial><nontuberculosis mycobacterial><nontuberculous mycobacteria><nontuberculous mycobacterial><novel><old mice><ontogeny><patient oriented outcomes><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phase II protocol><population aging><pre-clinical efficacy><preclinical efficacy><prevent><preventing><prophylactic><prototype><pulmonary><pulmonary histology><quality of life improvement><replicon vaccine><rheumatic arthritis><senior citizen><sex as a biological factor><sex as a biological measure><sex as a biological risk factor><sex as a biological variable><sex as a biological variance><sex as a biologically significant variable><sex as a fundamental variable><side effect><therapeutic efficacy><therapy efficacy><tuberculosis infection><tuberculous spondyloarthropathy><vaccine candidate><vaccine development><vaccine efficacy><vaccine evaluation><vaccine screening><vaccine testing><vulnerable group><vulnerable individual><vulnerable people><♀><♂>
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Nirbhay Kumar

GEORGE WASHINGTON UNIVERSITY, WASHINGTON, DC

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$795,296
FY 2026

Project Title

mRNA-LNP vaccines targeting multiple stages and multiple species of human malaria parasite

Grant Number:

5R01AI183533-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/26/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Malaria remains a major public health problem with an estimated ¼ billion clinical cases and mortality to a total of 627,000 in 2022. More than 90% of the global malaria burden is due to infection by Plasmodium falciparum and P. vivax, often co-endemic in Asia, Pacific, Central and S...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><Africa><Alleles><Allelomorphs><Animal Model><Animal Models and Related Studies><Antibody Response><Antigen Targeting><Antigens><Asia><Benchmarking><Best Practice Analysis><Blood erythrocyte><COVID-19 virus><COVID19 virus><Central America><Cessation of life><Chimera Protein><Chimeric Proteins><Clinical><Clinical Trials><CoV-2><CoV2><Combination Vaccines><Combined Vaccines><Communicable Diseases><Culicidae><Data><Death><Development><Erythrocytes><Erythrocytic><Evaluation><Exhibits><Female><Foundations><Fusion Protein><Future><Goals><Human><Immune><Immune response><Immunes><Immunity><Immunization><Individual><Infection><Infectious Diseases><Infectious Disorder><Interruption><Length of Life><Life Cycle><Life Cycle Stages><Longevity><M mulatta><M. mulatta><Macaca mulatta><Macaca rhesus><Malaria><Malaria Vaccines><Malarial Vaccines><Marrow erythrocyte><Messenger RNA><Mice><Mice Mammals><Modern Man><Mosquitoes><Murine><Mus><P falciparum><P vivax><P. falciparum><P. vivax><P.falciparum><Paludism><Parasites><Peptide Domain><Plasmodium><Plasmodium Infections><Plasmodium falciparum><Plasmodium vivax><Play><Protein Domains><Public Health><Publishing><Red Blood Cells><Red Cell><Rhesus Macaque><Rhesus Monkey><Role><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome related corona virus 2><Solid><South America><Sporozoites><Tertiary Protein Structure><Transmission><Vaccination><Vaccine Antigen><Vaccines><Wuhan coronavirus><asexual><benchmark><blood corpuscles><burden of disease><burden of illness><circumsporozoite protein><coronavirus disease 2019 virus><coronavirus disease-19 virus><cs protein><design><designing><develop a vaccine><develop vaccines><development of a vaccine><developmental><disease burden><flexibility><flexible><hCoV19><host response><human pathogen><immune system response><immunogen><immunogenicity><immunoresponse><improved><innovate><innovation><innovative><life course><mRNA><mRNA lipid nano particle vaccine><mRNA-LNP based vaccine><mRNA-LNP combination vaccines><mRNA-LNP vaccines><malaria infection><malaria transmission><malaria-infected><malarial infection><male><model of animal><mortality><nCoV2><non-human primate><nonhuman primate><phase 1 trial><phase I trial><pre-clinical><pre-clinical study><preclinical><preclinical study><protective efficacy><public health relevance><social role><tool><transmission blocking><transmission process><transmission-blocking vaccine><vaccine candidate><vaccine development><vaccine platform><vaccines against malaria><♀><♂>
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Richard Daniel Goldstein

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$705,715
FY 2026

Project Title

Multiomic Investigation of Sudden Unexplained Pediatric Deaths

Grant Number:

1R01NS142597-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY This proposal responds to the Notice of Special Interest “Understanding Sudden Death in the Young” (SDY) (NOT-HL-22-040) by building on our previous body of research in Robert’s Program on SUDP (Sudden Unexpected Death in Pediatrics) at Boston Children’s Hospital with additional phen...

Research Terms

<0-11 years old><1 year of age><1 year old><20 year old><20 years of age><5-HT><5-Hydroxytryptamine><5HT><Affect><Ammon Horn><Autopsy><Biochemical><Biological><Boston><Brain><Brain Nervous System><Brain Stem><Brainstem><Brugada syndrome><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiomyopathies><Causality><Cessation of life><Child><Child Youth><Childhood><Childhood Cancers><Children (0-21)><Children's Hospital><Clinical><Clinical Data><Copy Number Polymorphism><Cornu Ammonis><Cot Death><Coupled><Crib Death><Data><Death><Development><Disease><Disorder><Early Diagnosis><Early Intervention><Encephalon><Enteramine><Environment><Epilepsy><Epileptic Seizures><Epileptics><Etiology><Family><Febrile Convulsion Seizure><Febrile Convulsions><Febrile Fit><Febrile Seizures><Fever Convulsion><Fever Seizure><Forensic Medicine><Forensics><Funding><GWA study><GWAS><Gene variant><Genes><Genetic><Genetic Risk><Genetic study><Genome><Genomics><Goals><Grant><HRMS><Heart><Heart Diseases><Hippocampus><Hippophaine><Individual><Infant><Intervention Strategies><Investigation><Lesion><Liquid Chromatography><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant childhood cancer><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Metabolic><Metabolic Diseases><Metabolic Disorder><Methods><Molecular><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><NIH><National Institutes of Health><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Outcome><Parents><Pathogenicity><Pathologic><Pediatric Hospitals><Pediatric Research><Pediatrics><Phase><Phenotype><Predisposition><Prevention><Process><Public Health><Pyrexial Convulsion><Pyrexial Seizure><Registries><Repetitive Element><Repetitive Regions><Repetitive Sequence><Reporting><Research><Risk><Risk Factors><Role><SIDS><Seizure Disorder><Serotonin><Sleep><Sudden Death><Sudden Infant Death><Sudden Unexpected Infant Death><Sudden infant death syndrome><Susceptibility><Systemic disease><Techniques><Thesaurismosis><United States><United States National Institutes of Health><Variant><Variation><age 1><age 1 year><age 20><age 20 years><aged><aged 1 year><aged one year><allelic variant><base><bases><biobank><biologic><biorepository><cancer in a child><cancer in children><causation><child with cancer><childhood malignancy><cohort><copy number variant><copy number variation><developmental><disease causation><early detection><empowerment><epilepsia><epileptogenic><exome sequencing><exome-seq><genetic analysis><genetic risk assessment><genetic variant><genome sequencing><genome wide analysis><genome wide association><genome wide association scan><genome wide association study><genome wide studies><genome-wide analysis><genome-wide identification><genomewide association scan><genomewide association study><genomic variant><heart disorder><high resolution mass spec><high resolution mass spectrometry><high resolution mass spectroscopy><high-resolution mass spectrometer><hippocampal><innovate><innovation><innovative><insight><interdisciplinary approach><interest><investigate prospective><kids><long read seq><long-read sequencing><long-read transcript sequencing><metabolism disorder><metabolism measurement><metabolomics><metabonomics><monogenic disease><monogenic disorder><mortality><multidisciplinary><multidisciplinary approach><multiomics><multiple omics><myocardium disease><myocardium disorder><necropsy><neurological disease><neuropathologic><neuropathological><neuropathology><novel><one year of age><one year old><panomics><parent><pediatric><pediatric cancer><pediatric malignancy><phenotypic data><polygenetic risk scores><polygenic predictors><polygenic risk score><polygenic scores><postmortem><prevent><preventing><proband><programs><prospective><prospective investigation><prospective research><respiratory><risk minimization><single-gene disease><single-gene disorder><social role><study prospective><survey prospective><trait><twenty year old><twenty years of age><unclassified variant><variant of uncertain clinical significance><variant of uncertain significance><variant of undetermined significance><variant of unknown significance><whole genome association analysis><whole genome association study><youngster>
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Ingrid Adele Holm

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$705,715
FY 2026

Project Title

Multiomic Investigation of Sudden Unexplained Pediatric Deaths

Grant Number:

1R01NS142597-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY This proposal responds to the Notice of Special Interest “Understanding Sudden Death in the Young” (SDY) (NOT-HL-22-040) by building on our previous body of research in Robert’s Program on SUDP (Sudden Unexpected Death in Pediatrics) at Boston Children’s Hospital with additional phen...

Research Terms

<0-11 years old><1 year of age><1 year old><20 year old><20 years of age><5-HT><5-Hydroxytryptamine><5HT><Affect><Ammon Horn><Autopsy><Biochemical><Biological><Boston><Brain><Brain Nervous System><Brain Stem><Brainstem><Brugada syndrome><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiomyopathies><Causality><Cessation of life><Child><Child Youth><Childhood><Childhood Cancers><Children (0-21)><Children's Hospital><Clinical><Clinical Data><Copy Number Polymorphism><Cornu Ammonis><Cot Death><Coupled><Crib Death><Data><Death><Development><Disease><Disorder><Early Diagnosis><Early Intervention><Encephalon><Enteramine><Environment><Epilepsy><Epileptic Seizures><Epileptics><Etiology><Family><Febrile Convulsion Seizure><Febrile Convulsions><Febrile Fit><Febrile Seizures><Fever Convulsion><Fever Seizure><Forensic Medicine><Forensics><Funding><GWA study><GWAS><Gene variant><Genes><Genetic><Genetic Risk><Genetic study><Genome><Genomics><Goals><Grant><HRMS><Heart><Heart Diseases><Hippocampus><Hippophaine><Individual><Infant><Intervention Strategies><Investigation><Lesion><Liquid Chromatography><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant childhood cancer><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Metabolic><Metabolic Diseases><Metabolic Disorder><Methods><Molecular><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><NIH><National Institutes of Health><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Outcome><Parents><Pathogenicity><Pathologic><Pediatric Hospitals><Pediatric Research><Pediatrics><Phase><Phenotype><Predisposition><Prevention><Process><Public Health><Pyrexial Convulsion><Pyrexial Seizure><Registries><Repetitive Element><Repetitive Regions><Repetitive Sequence><Reporting><Research><Risk><Risk Factors><Role><SIDS><Seizure Disorder><Serotonin><Sleep><Sudden Death><Sudden Infant Death><Sudden Unexpected Infant Death><Sudden infant death syndrome><Susceptibility><Systemic disease><Techniques><Thesaurismosis><United States><United States National Institutes of Health><Variant><Variation><age 1><age 1 year><age 20><age 20 years><aged><aged 1 year><aged one year><allelic variant><base><bases><biobank><biologic><biorepository><cancer in a child><cancer in children><causation><child with cancer><childhood malignancy><cohort><copy number variant><copy number variation><developmental><disease causation><early detection><empowerment><epilepsia><epileptogenic><exome sequencing><exome-seq><genetic analysis><genetic risk assessment><genetic variant><genome sequencing><genome wide analysis><genome wide association><genome wide association scan><genome wide association study><genome wide studies><genome-wide analysis><genome-wide identification><genomewide association scan><genomewide association study><genomic variant><heart disorder><high resolution mass spec><high resolution mass spectrometry><high resolution mass spectroscopy><high-resolution mass spectrometer><hippocampal><innovate><innovation><innovative><insight><interdisciplinary approach><interest><investigate prospective><kids><long read seq><long-read sequencing><long-read transcript sequencing><metabolism disorder><metabolism measurement><metabolomics><metabonomics><monogenic disease><monogenic disorder><mortality><multidisciplinary><multidisciplinary approach><multiomics><multiple omics><myocardium disease><myocardium disorder><necropsy><neurological disease><neuropathologic><neuropathological><neuropathology><novel><one year of age><one year old><panomics><parent><pediatric><pediatric cancer><pediatric malignancy><phenotypic data><polygenetic risk scores><polygenic predictors><polygenic risk score><polygenic scores><postmortem><prevent><preventing><proband><programs><prospective><prospective investigation><prospective research><respiratory><risk minimization><single-gene disease><single-gene disorder><social role><study prospective><survey prospective><trait><twenty year old><twenty years of age><unclassified variant><variant of uncertain clinical significance><variant of uncertain significance><variant of undetermined significance><variant of unknown significance><whole genome association analysis><whole genome association study><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Monica Hsiung Wojcik

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$705,715
FY 2026

Project Title

Multiomic Investigation of Sudden Unexplained Pediatric Deaths

Grant Number:

1R01NS142597-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY This proposal responds to the Notice of Special Interest “Understanding Sudden Death in the Young” (SDY) (NOT-HL-22-040) by building on our previous body of research in Robert’s Program on SUDP (Sudden Unexpected Death in Pediatrics) at Boston Children’s Hospital with additional phen...

Research Terms

<0-11 years old><1 year of age><1 year old><20 year old><20 years of age><5-HT><5-Hydroxytryptamine><5HT><Affect><Ammon Horn><Autopsy><Biochemical><Biological><Boston><Brain><Brain Nervous System><Brain Stem><Brainstem><Brugada syndrome><Cardiac><Cardiac Diseases><Cardiac Disorders><Cardiomyopathies><Causality><Cessation of life><Child><Child Youth><Childhood><Childhood Cancers><Children (0-21)><Children's Hospital><Clinical><Clinical Data><Copy Number Polymorphism><Cornu Ammonis><Cot Death><Coupled><Crib Death><Data><Death><Development><Disease><Disorder><Early Diagnosis><Early Intervention><Encephalon><Enteramine><Environment><Epilepsy><Epileptic Seizures><Epileptics><Etiology><Family><Febrile Convulsion Seizure><Febrile Convulsions><Febrile Fit><Febrile Seizures><Fever Convulsion><Fever Seizure><Forensic Medicine><Forensics><Funding><GWA study><GWAS><Gene variant><Genes><Genetic><Genetic Risk><Genetic study><Genome><Genomics><Goals><Grant><HRMS><Heart><Heart Diseases><Hippocampus><Hippophaine><Individual><Infant><Intervention Strategies><Investigation><Lesion><Liquid Chromatography><Malignant Childhood Neoplasm><Malignant Childhood Tumor><Malignant Pediatric Neoplasm><Malignant Pediatric Tumor><Malignant childhood cancer><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Metabolic><Metabolic Diseases><Metabolic Disorder><Methods><Molecular><Myocardial Diseases><Myocardial Disorder><Myocardiopathies><NIH><National Institutes of Health><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Outcome><Parents><Pathogenicity><Pathologic><Pediatric Hospitals><Pediatric Research><Pediatrics><Phase><Phenotype><Predisposition><Prevention><Process><Public Health><Pyrexial Convulsion><Pyrexial Seizure><Registries><Repetitive Element><Repetitive Regions><Repetitive Sequence><Reporting><Research><Risk><Risk Factors><Role><SIDS><Seizure Disorder><Serotonin><Sleep><Sudden Death><Sudden Infant Death><Sudden Unexpected Infant Death><Sudden infant death syndrome><Susceptibility><Systemic disease><Techniques><Thesaurismosis><United States><United States National Institutes of Health><Variant><Variation><age 1><age 1 year><age 20><age 20 years><aged><aged 1 year><aged one year><allelic variant><base><bases><biobank><biologic><biorepository><cancer in a child><cancer in children><causation><child with cancer><childhood malignancy><cohort><copy number variant><copy number variation><developmental><disease causation><early detection><empowerment><epilepsia><epileptogenic><exome sequencing><exome-seq><genetic analysis><genetic risk assessment><genetic variant><genome sequencing><genome wide analysis><genome wide association><genome wide association scan><genome wide association study><genome wide studies><genome-wide analysis><genome-wide identification><genomewide association scan><genomewide association study><genomic variant><heart disorder><high resolution mass spec><high resolution mass spectrometry><high resolution mass spectroscopy><high-resolution mass spectrometer><hippocampal><innovate><innovation><innovative><insight><interdisciplinary approach><interest><investigate prospective><kids><long read seq><long-read sequencing><long-read transcript sequencing><metabolism disorder><metabolism measurement><metabolomics><metabonomics><monogenic disease><monogenic disorder><mortality><multidisciplinary><multidisciplinary approach><multiomics><multiple omics><myocardium disease><myocardium disorder><necropsy><neurological disease><neuropathologic><neuropathological><neuropathology><novel><one year of age><one year old><panomics><parent><pediatric><pediatric cancer><pediatric malignancy><phenotypic data><polygenetic risk scores><polygenic predictors><polygenic risk score><polygenic scores><postmortem><prevent><preventing><proband><programs><prospective><prospective investigation><prospective research><respiratory><risk minimization><single-gene disease><single-gene disorder><social role><study prospective><survey prospective><trait><twenty year old><twenty years of age><unclassified variant><variant of uncertain clinical significance><variant of uncertain significance><variant of undetermined significance><variant of unknown significance><whole genome association analysis><whole genome association study><youngster>
View Full Project Details on NIH Reporter
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Lisa Marie Knowlton

STANFORD UNIVERSITY, STANFORD, CA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$702,185
FY 2026

Project Title

Increasing Medicaid Acquisition and Sustainment among the Uninsured

Grant Number:

5R01MD018773-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/30/2023

End Date:

12/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Uninsured patients are subject to catastrophic health expenditures, have higher rates of mortality, and far more limited availability of important healthcare resources (e.g., preventative or specialist care, rehabilitation, mental health) compared to insured patients. Uninsured individuals often def...

Research Terms

<21+ years old><Accident and Emergency department><Active Follow-up><Address><Adult><Adult Human><American><Black><Black race><California><Caring><Case Study><Case-Base Studies><Characteristics><Clinical><Collaborations><Counseling><County><Data><Data Set><Death Rate><Development><Discipline><Disease><Disorder><Eligibility><Eligibility Determination><Emergencies><Emergency Department><Emergency Situation><Emergency room><Enrollment><Espanol><Factor Analyses><Factor Analysis><Feedback><Focus Groups><Funding><Future><Geography><Goals><Health><Health Care><Health Expenditures><Health Services><Health system><Hispanic><Hospital Admission><Hospital Personnel><Hospitalization><Hospitals><Individual><Inpatients><Insurance><Insurance Coverage><Insurance Status><Intervention><Interview><Investigation><Job loss><Knowledge><Left><Location><Logistic Regressions><Low income><Medicaid><Medical><Medical Rehabilitation><Mental Health><Mental Hygiene><Methods><Modeling><NCMHD><NIMHD><National Center on Minority Health and Health Disparities><National Institute of Minority Health and Health Disparities><National Institute on Minority Health and Health Disparities><Operative Procedures><Operative Surgical Procedures><Outcome><Patients><Policy Maker><Preventive><Protocol Screening><Psychological Health><Rehabilitation><Rehabilitation therapy><Sampling><Site><Social Service><Social Work><Solvents><Spanish><Specialist><Structure><Surgical><Surgical Interventions><Surgical Procedure><Testing><Time><Training><Uncompensated Care><Underinsured><Uninsured><Work><active followup><adulthood><care resources><case report><cost><developmental><differences in health><effectiveness study><enroll><evidence base><follow up><follow-up><followed up><followup><health care expenditure><health care resources><health care service><health difference><health service use><health service utilization><implementation study><improved><innovate><innovation><innovative><medical expenditure><mortality rate><novel><participant enrollment><patient enrollment><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><point of care><process improvement><programs><rehab therapy><rehabilitative><rehabilitative therapy><response><socio-demographics><sociodemographics><success><surgery><system-level barriers><tool><usability>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

MATHEW S MAURER

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$688,635
FY 2026

Project Title

Analysis of Lumbar Spine Stenosis Specimens for Identification of Transthyretin Cardiac Amyloidosis

Grant Number:

5R01AG081582-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2023

End Date:

2/29/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Transthyretin (TTR) amyloidosis (ATTR) is a form of systemic amyloidosis either caused by mutations in the TTR gene leading to aggregation and variant TTR amyloidosis (ATTRv; v is for variant) or from aggregation of wild type TTR leading to ATTRwt amyloidosis. ATTRwt is beco...

Research Terms

<AI system><Affect><Age><Age Years><Aging><Amyloid><Amyloid Substance><Amyloidosis><Arthroplasty><Artificial Intelligence><BMI><BMI percentile><BMI z-score><Biceps><Bilateral><Body Tissues><Body mass index><Cardiac><Carpal Tunnel Compression Neuropathy><Carpal Tunnel Entrapment Neuropathy><Carpal Tunnel Median Neuropathy><Carpal Tunnel Syndrome><Clinical><Computer Reasoning><Congo Red><Coxa><DNA mutation><Data><Denmark><Deposit><Deposition><Development><Diagnosis><Diphosphates><Disease><Disorder><Early Diagnosis><Early identification><Evaluation><Flaval Ligament><Future><Gamma Camera Imaging><Genes><Genetic Change><Genetic defect><Genetic mutation><Grant><Hip><Hip region structure><Histocompatibility Testing><Histologic><Histologically><Individual><Institution><Investigators><Joint Prosthesis Implantation><Knee><Machine Intelligence><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Morbidity><Mutation><Myocardial depression><Myocardial dysfunction><Nuclear><Operative Procedures><Operative Surgical Procedures><Orthopedic><Orthopedic Surgical Profession><Orthopedics><Outcome><Pathologic><Pathology><Patients><Population><Prealbumin><Prevalence><Proalbumin><Prospective, cohort study><Protein Precursors><Pyrophosphates><Quetelet index><Radioisotope Scanning><Radionuclide Imaging><Replacement Arthroplasty><Research Personnel><Research Specimen><Researchers><Risk><Sampling><Scintigraphy><Shoulder><Specimen><Spinal><Spinal Column><Spinal Stenosis><Spinal surgery><Spine><Spine surgery><Staining method><Stains><Surgical><Surgical Interventions><Surgical Procedure><Techniques><Testing><Time><Tissue Crossmatching><Tissue Typing><Tissues><Transthyretin><United States><Variant><Variation><Vertebral column><age associated><age correlated><age dependent><age linked><age related><age specific><ages><amyloid cardiomyopathy><amyloid disease><amyloid heart disease><assessing cost effectiveness><backbone><biceps brachii muscle><bone><cardiac amyloidosis><cardiac dysfunction><clinical practice><cohort><cost effective><cost-effectiveness evaluation><determine cost effectiveness><developmental><early detection><effective therapy><effective treatment><evaluate cost-effectiveness><examine cost effectiveness><experience><genome mutation><heart dysfunction><histocompatibility typing><improved outcome><joint arthroplasty><joint replacement><ligamentum flavum><male><mortality><novel><nuclear imaging><older adult><older adulthood><programs><radionuclide imaging/scanning><radionuclide scanning><rare condition><rare syndrome><repurposing><screening><screening program><screenings><surgery><tendon rupture><♂>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Robert Richard Flavell

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$678,334
FY 2026

Project Title

Selective treatment of acute myeloid leukemia with radioimmunotherapies targeting the active conformation of integrin beta-2

Grant Number:

5R01CA297845-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/7/2025

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT The Problem: Acute myeloid leukemia is a common blood cancer diagnosed in >20,000 Americans per year, but current therapies only lead to a dismal 5-year survival of ~30%. New treatments are urgently needed. While antibody-based immunotherapies targeting tumor surface protein...

Research Terms

<7S Gamma Globulin><AML - Acute Myeloid Leukemia><Acute><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><American><Anti-Cancer Agents><Antibodies><Antibody Therapy><Antigens><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Award><Beta 2 Integrin Chain><Biologic Models><Biological Models><Bone Marrow><Bone Marrow Reticuloendothelial System><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><CD11a Beta Subunit><CD11b Beta Subunit><CD11c Beta Subunit><CD123><CD123 Antigen><CD18><CD18 Antigens><CD33 antigen><Cancer Drug><Cancers><Cell Body><Cell Line><Cell Surface Antigens><Cell Surface Proteins><CellLine><Cells><Clinical><Clinical Trials><Collaborations><Data><Development><Diagnosis><Disease><Disorder><Down-Regulation><Drugs><Early-Stage Clinical Trials><Endothelial Cells><FDA approved><Failure><Funding><Future><Goals><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoiesis><Hematopoietic><Hematopoietic Cancer><Hematopoietic Cell Tumor><Hematopoietic Cellular Control Mechanisms><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Heterograft><Heterologous Transplantation><Human><Human Cell Line><IL3R><IL3RA><IL3RA gene><IL3RAX><IL3RX><ITGB2><ITGB2 gene><IgG><Immune mediated therapy><Immune system><Immunoglobulin G><Immunological Surface Markers><Immunologically Directed Therapy><Immunoradiotherapy><Immunotherapy><In vivo analysis><Increase lifespan><Integrin Beta-2><Integrin beta2><Integrins><Integrins Extracellular Matrix><Interleukin 3 Receptor Alpha><LCAMB><Lead><Leukemic Cell><Literature><MF17><Malignant Hematologic Neoplasm><Malignant Hematopoietic Neoplasm><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of prostate><Malignant prostatic tumor><Measures><Medical><Medication><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Mice><Mice Mammals><Modality><Model System><Modeling><Modern Man><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Multiple Myeloma><Murine><Mus><Myelogenous><Myeloid><Myeloid Cells><Nature><Neoplastic Disease Chemotherapeutic Agents><Neuroendocrine Neoplasm><Neuroendocrine Tumors><Outcome><PDX model><Patient derived xenograft><Patients><Pb element><Pharmaceutical Preparations><Phase 1 Clinical Trials><Phase I Clinical Trials><Phenotype><Plasma-Cell Myeloma><Prognosis><Prostate CA><Prostate Cancer><Prostate malignancy><Protein Conformation><Proteomics><Publishing><Radiation Dosimetry><Radioimmunotherapy><Radiometry><Radionuclide therapy><Radiopharmaceutical Compound><Radiopharmaceuticals><Radiotheranostics><Research><Resistance><Safety><Sampling><Solid Neoplasm><Solid Tumor><Strains Cell Lines><Surface Antigens><Surface Proteins><T cells for CAR><Technology><Testing><Theranostic Radiopharmaceuticals><Therapeutic><Therapeutic Index><Therapeutic Uses><Therapeutic antibodies><Toxic effect><Toxicities><Treatment Efficacy><Tumor-Specific Treatment Agents><Validation><Work><Xenograft><Xenograft procedure><Xenotransplantation><acute granulocytic leukemia><acute myeloid leukemia><anti-cancer><anti-cancer drug><anti-cancer immunotherapy><antibody based therapies><antibody treatment><antibody-based therapeutics><antibody-based treatment><anticancer immunotherapy><blood cancer><blood cell formation><boost longevity><cancer diagnosis><cancer immunotherapy><cancer microenvironment><cancer of blood><cancer of the blood><chimeric antigen T cell receptor><chimeric antigen receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><clinical efficacy><clinical investigation><clinical translation><clinically translatable><conformation><conformational><conformational state><conformationally><conformations><cultured cell line><developmental><drug/agent><effective therapy><effective treatment><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><foster longevity><glycoprotein gp67><heavy metal Pb><heavy metal lead><hematopoietic tissue><hemopoietic><immune microenvironment><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><immunotherapy for cancer><immunotherapy of cancer><improve lifespan><improve longevity><improved><in vitro testing><in vivo><in vivo evaluation><in vivo testing><innovate><innovation><innovative><interest><intervention efficacy><leukemia treatment><leukemic therapy><lifespan extension><malignancy><multiomics><multiple omics><myeloma><myelomatosis><neoplasm/cancer><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><panomics><patient derived xenograft model><phase 1 trial><phase I protocol><phase I trial><pre-clinical><pre-clinical efficacy><pre-clinical evaluation><pre-clinical safety><pre-clinical toxicity><preclinical><preclinical efficacy><preclinical evaluation><preclinical safety><preclinical toxicity><prevent><preventing><prolong lifespan><prolong longevity><promote lifespan><promote longevity><radioactive drugs><radioassay><radionuclide theranostics><radionuclide-based theranostics><radiopharmaceutical-based theranostics><radiotherapeutic drugs><resistance mechanism><resistant><resistant mechanism><small molecule><support longevity><therapeutic efficacy><therapeutic radionuclide><therapy efficacy><translation strategy><translational approach><translational strategy><trial design><tumor><tumor immune microenvironment><tumor microenvironment><tumor specificity><tumor-immune system interactions><validations><xeno-transplant><xeno-transplantation>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Arun P. Wiita

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$678,334
FY 2026

Project Title

Selective treatment of acute myeloid leukemia with radioimmunotherapies targeting the active conformation of integrin beta-2

Grant Number:

5R01CA297845-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/7/2025

End Date:

2/28/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT The Problem: Acute myeloid leukemia is a common blood cancer diagnosed in >20,000 Americans per year, but current therapies only lead to a dismal 5-year survival of ~30%. New treatments are urgently needed. While antibody-based immunotherapies targeting tumor surface protein...

Research Terms

<7S Gamma Globulin><AML - Acute Myeloid Leukemia><Acute><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Address><American><Anti-Cancer Agents><Antibodies><Antibody Therapy><Antigens><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Award><Beta 2 Integrin Chain><Biologic Models><Biological Models><Bone Marrow><Bone Marrow Reticuloendothelial System><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><CD11a Beta Subunit><CD11b Beta Subunit><CD11c Beta Subunit><CD123><CD123 Antigen><CD18><CD18 Antigens><CD33 antigen><Cancer Drug><Cancers><Cell Body><Cell Line><Cell Surface Antigens><Cell Surface Proteins><CellLine><Cells><Clinical><Clinical Trials><Collaborations><Data><Development><Diagnosis><Disease><Disorder><Down-Regulation><Drugs><Early-Stage Clinical Trials><Endothelial Cells><FDA approved><Failure><Funding><Future><Goals><Hematologic Cancer><Hematologic Malignancies><Hematologic Neoplasms><Hematological Malignancies><Hematological Neoplasms><Hematological Tumor><Hematopoiesis><Hematopoietic><Hematopoietic Cancer><Hematopoietic Cell Tumor><Hematopoietic Cellular Control Mechanisms><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Heterograft><Heterologous Transplantation><Human><Human Cell Line><IL3R><IL3RA><IL3RA gene><IL3RAX><IL3RX><ITGB2><ITGB2 gene><IgG><Immune mediated therapy><Immune system><Immunoglobulin G><Immunological Surface Markers><Immunologically Directed Therapy><Immunoradiotherapy><Immunotherapy><In vivo analysis><Increase lifespan><Integrin Beta-2><Integrin beta2><Integrins><Integrins Extracellular Matrix><Interleukin 3 Receptor Alpha><LCAMB><Lead><Leukemic Cell><Literature><MF17><Malignant Hematologic Neoplasm><Malignant Hematopoietic Neoplasm><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of prostate><Malignant prostatic tumor><Measures><Medical><Medication><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Mice><Mice Mammals><Modality><Model System><Modeling><Modern Man><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Multiple Myeloma><Murine><Mus><Myelogenous><Myeloid><Myeloid Cells><Nature><Neoplastic Disease Chemotherapeutic Agents><Neuroendocrine Neoplasm><Neuroendocrine Tumors><Outcome><PDX model><Patient derived xenograft><Patients><Pb element><Pharmaceutical Preparations><Phase 1 Clinical Trials><Phase I Clinical Trials><Phenotype><Plasma-Cell Myeloma><Prognosis><Prostate CA><Prostate Cancer><Prostate malignancy><Protein Conformation><Proteomics><Publishing><Radiation Dosimetry><Radioimmunotherapy><Radiometry><Radionuclide therapy><Radiopharmaceutical Compound><Radiopharmaceuticals><Radiotheranostics><Research><Resistance><Safety><Sampling><Solid Neoplasm><Solid Tumor><Strains Cell Lines><Surface Antigens><Surface Proteins><T cells for CAR><Technology><Testing><Theranostic Radiopharmaceuticals><Therapeutic><Therapeutic Index><Therapeutic Uses><Therapeutic antibodies><Toxic effect><Toxicities><Treatment Efficacy><Tumor-Specific Treatment Agents><Validation><Work><Xenograft><Xenograft procedure><Xenotransplantation><acute granulocytic leukemia><acute myeloid leukemia><anti-cancer><anti-cancer drug><anti-cancer immunotherapy><antibody based therapies><antibody treatment><antibody-based therapeutics><antibody-based treatment><anticancer immunotherapy><blood cancer><blood cell formation><boost longevity><cancer diagnosis><cancer immunotherapy><cancer microenvironment><cancer of blood><cancer of the blood><chimeric antigen T cell receptor><chimeric antigen receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><clinical efficacy><clinical investigation><clinical translation><clinically translatable><conformation><conformational><conformational state><conformationally><conformations><cultured cell line><developmental><drug/agent><effective therapy><effective treatment><elongating the lifespan><enhance longevity><extend life span><extend lifespan><extend longevity><foster longevity><glycoprotein gp67><heavy metal Pb><heavy metal lead><hematopoietic tissue><hemopoietic><immune microenvironment><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><immunotherapy for cancer><immunotherapy of cancer><improve lifespan><improve longevity><improved><in vitro testing><in vivo><in vivo evaluation><in vivo testing><innovate><innovation><innovative><interest><intervention efficacy><leukemia treatment><leukemic therapy><lifespan extension><malignancy><multiomics><multiple omics><myeloma><myelomatosis><neoplasm/cancer><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><panomics><patient derived xenograft model><phase 1 trial><phase I protocol><phase I trial><pre-clinical><pre-clinical efficacy><pre-clinical evaluation><pre-clinical safety><pre-clinical toxicity><preclinical><preclinical efficacy><preclinical evaluation><preclinical safety><preclinical toxicity><prevent><preventing><prolong lifespan><prolong longevity><promote lifespan><promote longevity><radioactive drugs><radioassay><radionuclide theranostics><radionuclide-based theranostics><radiopharmaceutical-based theranostics><radiotherapeutic drugs><resistance mechanism><resistant><resistant mechanism><small molecule><support longevity><therapeutic efficacy><therapeutic radionuclide><therapy efficacy><translation strategy><translational approach><translational strategy><trial design><tumor><tumor immune microenvironment><tumor microenvironment><tumor specificity><tumor-immune system interactions><validations><xeno-transplant><xeno-transplantation>
View Full Project Details on NIH Reporter
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Arielle Hope Sheftall

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Good lead · 58/100
Likely hiring
Solid budget
Recent
Active award
$409,859
FY 2026

Project Title

Effects of parental history of suicidal behavior on middle/late childhood: Longitudinal assessment of early markers of suicide risk

Grant Number:

5R01MH125905-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

1/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY/ABSTRACT Suicide is the fifth leading cause of death among U.S. children 5 to 12 years, yet limited research on childhood suicide and suicidal behavior (SB) exists. The National Institute of Mental Health (NIMH) has acknowledged this critical gap as a high research priority. A signif...

Research Terms

<0-11 years old><12-20 years old><5 year old><5 years of age><6 year old><6 years of age><9 year old><9 years of age><Adolescence><Adolescent><Adolescent Youth><Age of Onset><Arousal><Arousal and Regulatory Systems><Arousal/Regulatory Systems><Attention><Behavioral><Biological><Black><Black race><Cause of Death><Child><Child Youth><Childhood><Children (0-21)><Development><Dysfunction><ED visit><ER visit><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><Emotional><Enrollment><Family><Feeling suicidal><Female><Functional disorder><Future><Goals><Groups at risk><History><IQ Deficit><Intervention><Interview><Knowledge><Learning><Measures><Mediating><Mediator><Mental Health><Mental Hygiene><Methods><NIMH><National Institute of Mental Health><Neurocognitive><Neurocognitive Deficit><Parents><Participant><Patient Self-Report><People at risk><Persons at risk><Physiopathology><Population Heterogeneity><Populations at Risk><Positive Valence><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Primary Prevention><Psychological Health><Public Health><RDoC><Race><Races><Racial Group><Recording of previous events><Regulation><Research><Research Domain Criteria><Research Priority><Rewards><Risk><Risk Factors><Role><Sampling><Self-Report><Social Processes><Strategic Planning><Suicidal thoughts><Suicide><Suicide attempt><System><Techniques><Testing><Transmission><Visit><Youth><Youth 10-21><adolescence (12-20)><age 5><age 5 years><age 6><age 6 years><age 9><age 9 years><age associated><age correlated><age dependent><age group><age linked><age related><age specific><biologic><black female><black male><black man><black men><black women><cognitive control><cognitive system><cohort><computerized><developmental><disparities in race><disparities in sex><disparity due to race><diverse populations><early onset><emotion dysregulation><emotional dysregulation><enroll><experience><externalizing behavior><fatal attempt><fatal suicide><five year old><five years of age><heterogeneous population><high risk><high risk group><high risk individual><high risk people><high risk population><histories><inequality due to race><inequity due to race><intelligence quotient deficit><intent to die><juvenile><juvenile human><kids><male><neurocognitive decline><neurocognitive impairment><nine year old><nine years of age><non fatal attempt><non-suicidal self injury><nonfatal attempt><nonsuicidal self injury><offspring><parent><pathophysiology><pediatric><peer><population diversity><prevent><preventing><race based disparity><race based inequality><race based inequity><race disparity><race related disparity><race related inequality><race related inequity><racial><racial background><racial disparity><racial inequality><racial inequity><racial origin><racial population><racial subgroup><racially unequal><recruit><sex><sex disparity><six year old><six years of age><social communication><social role><suicidal adolescent><suicidal adolescents><suicidal attempt><suicidal behavior><suicidal ideation><suicidal risk><suicidal thinking><suicidal youth><suicidal youths><suicide behavior><suicide ideation><suicide rate><suicide risk><suicides><thoughts about suicide><transmission process><trend><younger age><youngster><youth age><♀><♂>
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ALAN N BAER

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 54/100
Large award
Recent
Active award
Team-scale grant
$1,950,000
FY 2026

Project Title

Sjögren’s Team for Accelerating Medicines Partnership (STAMP)

Grant Number:

5UC2DE032254-05

Activity Code:

UC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/7/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Sjögren’s Disease (SjD, formerly known as Sjögren’s syndrome) is a common systemic autoimmune rheumatic disorder second only to rheumatoid arthritis in prevalence. It primarily affects salivary and lacrimal glands through lymphocytic infiltration and autoantibody-mediated inflammation, resu...

Research Terms

<Acceleration><Active Follow-up><Address><Adopted><Advisory Committees><Affect><American><Arthralgia><Asialia><Atlases><Atrophic Arthritis><Autoantibodies><Autoimmune><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Award><Biological><Biological Markers><Body Tissues><Calibration><California><Cell Body><Cells><Classification><Clinic><Clinical><Clinical Data><Clinical Research><Clinical Research Protocols><Clinical Study><Clinical Trials><Clinical assessments><Collaborations><DNA Methylation><DNA Molecular Biology><Data><Derivation><Derivation procedure><Diagnosis><Disease><Disorder><Dysfunction><Early Diagnosis><Enrollment><Epidemiology><European><Exocrine Glands><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Fatigue><Foundations><Functional disorder><Funding><Future><GWA study><GWAS><Gene variant><Genetic><Genetic Heterogeneity><Genomics><Germinoblastic Sarcoma><Germinoblastoma><Goals><Heterogeneity><History><Hyposalivation><Immune><Immunes><Individual><Inflammation><International><Investigators><Joint Pain><Lack of Energy><Lacrimal Glands><Lacrimal deficiency><Lacrimal gland structure><Lymphocytic Infiltrate><Lymphoma><Malignant Lymphoma><Mediating><Medical Research><Medicine><Molecular><Molecular Analysis><Molecular Biology><Morbidity><Mouth Dryness><Musculoskeletal Pain Disorder><NIAMS><NIDCR><NIDR><National Institute of Arthritis, and Musculoskeletal, and Skin Diseases><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><Natural History><Nature><New York><Nuclear><Ocular desiccation><Oklahoma><Participant><Pathogenesis><Pathway interactions><Patient Care><Patient Care Delivery><Patient Recruitments><Patients><Phase><Phenotype><Physiopathology><Position><Positioning Attribute><Prevalence><Protocol><Protocols documentation><QOL><Quality of life><R21 Award><RNA Seq><RNA sequencing><RNAseq><Recording of previous events><Research><Research Personnel><Research Priority><Research Resources><Researchers><Resources><Reticulolymphosarcoma><Rheumatic Diseases><Rheumatism><Rheumatoid Arthritis><Rheumatologic Diseases><Rheumatologic Disorder><Rheumatology><Risk><Risk-associated variant><SCmRNAseq><Salivary Gland Tissue><Salivary Glands><Salivary hypofunction><Sampling><San Francisco><Scientist><Sicca Syndrome><Single cell mRNA seq><Site><Sjogren's Disease><Sjogren's Syndrome><Sjogrens><Sjögren Syndrome><Standardization><Syndrome><System><Systematics><Systems Biology><Task Forces><Technology><Therapeutic><Tissues><Translating><Universities><Validation><Work><Xerostomia><Xerostomic><active followup><advisory team><allelic variant><aptyalism><autoimmune antibody><autoimmune condition><autoimmune disorder><autoimmunity disease><autoreactive antibody><bio-markers><biologic><biologic marker><biomarker><care for patients><care of patients><caring for patients><cell type><cohort><college><collegiate><deep sequencing><design><designing><dry eye><dry mouth><early detection><effective therapy><effective treatment><enroll><entire genome><epidemiologic><epidemiological><eye dryness><follow up><follow-up><followed up><followup><full genome><genetic association><genetic etiology><genetic mechanism of disease><genetic variant><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic variant><high risk><histories><improved><manage symptom><multidisciplinary><ocular dryness><ocular signs of dryness><ocular surface dryness><oral dryness><participant recruitment><pathophysiology><pathway><pre-clinical><preclinical><reconstruction><recruit><response><rheumatic arthritis><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><salivary gland hypofunction><scRNA sequencing><scRNA-seq><scale up><self reactive antibody><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell mRNA sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><symptom management><systemic autoimmune disease><systemic autoimmune disorder><tear deficiency><therapeutic target><transcriptome sequencing><transcriptomic sequencing><validations><whole genome><whole genome association analysis><whole genome association study><xerodermosteosis>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

A Darise Farris

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 54/100
Large award
Recent
Active award
Team-scale grant
$1,950,000
FY 2026

Project Title

Sjögren’s Team for Accelerating Medicines Partnership (STAMP)

Grant Number:

5UC2DE032254-05

Activity Code:

UC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/7/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Sjögren’s Disease (SjD, formerly known as Sjögren’s syndrome) is a common systemic autoimmune rheumatic disorder second only to rheumatoid arthritis in prevalence. It primarily affects salivary and lacrimal glands through lymphocytic infiltration and autoantibody-mediated inflammation, resu...

Research Terms

<Acceleration><Active Follow-up><Address><Adopted><Advisory Committees><Affect><American><Arthralgia><Asialia><Atlases><Atrophic Arthritis><Autoantibodies><Autoimmune><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Award><Biological><Biological Markers><Body Tissues><Calibration><California><Cell Body><Cells><Classification><Clinic><Clinical><Clinical Data><Clinical Research><Clinical Research Protocols><Clinical Study><Clinical Trials><Clinical assessments><Collaborations><DNA Methylation><DNA Molecular Biology><Data><Derivation><Derivation procedure><Diagnosis><Disease><Disorder><Dysfunction><Early Diagnosis><Enrollment><Epidemiology><European><Exocrine Glands><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Fatigue><Foundations><Functional disorder><Funding><Future><GWA study><GWAS><Gene variant><Genetic><Genetic Heterogeneity><Genomics><Germinoblastic Sarcoma><Germinoblastoma><Goals><Heterogeneity><History><Hyposalivation><Immune><Immunes><Individual><Inflammation><International><Investigators><Joint Pain><Lack of Energy><Lacrimal Glands><Lacrimal deficiency><Lacrimal gland structure><Lymphocytic Infiltrate><Lymphoma><Malignant Lymphoma><Mediating><Medical Research><Medicine><Molecular><Molecular Analysis><Molecular Biology><Morbidity><Mouth Dryness><Musculoskeletal Pain Disorder><NIAMS><NIDCR><NIDR><National Institute of Arthritis, and Musculoskeletal, and Skin Diseases><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><Natural History><Nature><New York><Nuclear><Ocular desiccation><Oklahoma><Participant><Pathogenesis><Pathway interactions><Patient Care><Patient Care Delivery><Patient Recruitments><Patients><Phase><Phenotype><Physiopathology><Position><Positioning Attribute><Prevalence><Protocol><Protocols documentation><QOL><Quality of life><R21 Award><RNA Seq><RNA sequencing><RNAseq><Recording of previous events><Research><Research Personnel><Research Priority><Research Resources><Researchers><Resources><Reticulolymphosarcoma><Rheumatic Diseases><Rheumatism><Rheumatoid Arthritis><Rheumatologic Diseases><Rheumatologic Disorder><Rheumatology><Risk><Risk-associated variant><SCmRNAseq><Salivary Gland Tissue><Salivary Glands><Salivary hypofunction><Sampling><San Francisco><Scientist><Sicca Syndrome><Single cell mRNA seq><Site><Sjogren's Disease><Sjogren's Syndrome><Sjogrens><Sjögren Syndrome><Standardization><Syndrome><System><Systematics><Systems Biology><Task Forces><Technology><Therapeutic><Tissues><Translating><Universities><Validation><Work><Xerostomia><Xerostomic><active followup><advisory team><allelic variant><aptyalism><autoimmune antibody><autoimmune condition><autoimmune disorder><autoimmunity disease><autoreactive antibody><bio-markers><biologic><biologic marker><biomarker><care for patients><care of patients><caring for patients><cell type><cohort><college><collegiate><deep sequencing><design><designing><dry eye><dry mouth><early detection><effective therapy><effective treatment><enroll><entire genome><epidemiologic><epidemiological><eye dryness><follow up><follow-up><followed up><followup><full genome><genetic association><genetic etiology><genetic mechanism of disease><genetic variant><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic variant><high risk><histories><improved><manage symptom><multidisciplinary><ocular dryness><ocular signs of dryness><ocular surface dryness><oral dryness><participant recruitment><pathophysiology><pathway><pre-clinical><preclinical><reconstruction><recruit><response><rheumatic arthritis><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><salivary gland hypofunction><scRNA sequencing><scRNA-seq><scale up><self reactive antibody><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell mRNA sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><symptom management><systemic autoimmune disease><systemic autoimmune disorder><tear deficiency><therapeutic target><transcriptome sequencing><transcriptomic sequencing><validations><whole genome><whole genome association analysis><whole genome association study><xerodermosteosis>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

CAROLINE Helene SHIBOSKI

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Good lead · 54/100
Large award
Recent
Active award
Team-scale grant
$1,950,000
FY 2026

Project Title

Sjögren’s Team for Accelerating Medicines Partnership (STAMP)

Grant Number:

5UC2DE032254-05

Activity Code:

UC2

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/7/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

ABSTRACT Sjögren’s Disease (SjD, formerly known as Sjögren’s syndrome) is a common systemic autoimmune rheumatic disorder second only to rheumatoid arthritis in prevalence. It primarily affects salivary and lacrimal glands through lymphocytic infiltration and autoantibody-mediated inflammation, resu...

Research Terms

<Acceleration><Active Follow-up><Address><Adopted><Advisory Committees><Affect><American><Arthralgia><Asialia><Atlases><Atrophic Arthritis><Autoantibodies><Autoimmune><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Award><Biological><Biological Markers><Body Tissues><Calibration><California><Cell Body><Cells><Classification><Clinic><Clinical><Clinical Data><Clinical Research><Clinical Research Protocols><Clinical Study><Clinical Trials><Clinical assessments><Collaborations><DNA Methylation><DNA Molecular Biology><Data><Derivation><Derivation procedure><Diagnosis><Disease><Disorder><Dysfunction><Early Diagnosis><Enrollment><Epidemiology><European><Exocrine Glands><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Fatigue><Foundations><Functional disorder><Funding><Future><GWA study><GWAS><Gene variant><Genetic><Genetic Heterogeneity><Genomics><Germinoblastic Sarcoma><Germinoblastoma><Goals><Heterogeneity><History><Hyposalivation><Immune><Immunes><Individual><Inflammation><International><Investigators><Joint Pain><Lack of Energy><Lacrimal Glands><Lacrimal deficiency><Lacrimal gland structure><Lymphocytic Infiltrate><Lymphoma><Malignant Lymphoma><Mediating><Medical Research><Medicine><Molecular><Molecular Analysis><Molecular Biology><Morbidity><Mouth Dryness><Musculoskeletal Pain Disorder><NIAMS><NIDCR><NIDR><National Institute of Arthritis, and Musculoskeletal, and Skin Diseases><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><Natural History><Nature><New York><Nuclear><Ocular desiccation><Oklahoma><Participant><Pathogenesis><Pathway interactions><Patient Care><Patient Care Delivery><Patient Recruitments><Patients><Phase><Phenotype><Physiopathology><Position><Positioning Attribute><Prevalence><Protocol><Protocols documentation><QOL><Quality of life><R21 Award><RNA Seq><RNA sequencing><RNAseq><Recording of previous events><Research><Research Personnel><Research Priority><Research Resources><Researchers><Resources><Reticulolymphosarcoma><Rheumatic Diseases><Rheumatism><Rheumatoid Arthritis><Rheumatologic Diseases><Rheumatologic Disorder><Rheumatology><Risk><Risk-associated variant><SCmRNAseq><Salivary Gland Tissue><Salivary Glands><Salivary hypofunction><Sampling><San Francisco><Scientist><Sicca Syndrome><Single cell mRNA seq><Site><Sjogren's Disease><Sjogren's Syndrome><Sjogrens><Sjögren Syndrome><Standardization><Syndrome><System><Systematics><Systems Biology><Task Forces><Technology><Therapeutic><Tissues><Translating><Universities><Validation><Work><Xerostomia><Xerostomic><active followup><advisory team><allelic variant><aptyalism><autoimmune antibody><autoimmune condition><autoimmune disorder><autoimmunity disease><autoreactive antibody><bio-markers><biologic><biologic marker><biomarker><care for patients><care of patients><caring for patients><cell type><cohort><college><collegiate><deep sequencing><design><designing><dry eye><dry mouth><early detection><effective therapy><effective treatment><enroll><entire genome><epidemiologic><epidemiological><eye dryness><follow up><follow-up><followed up><followup><full genome><genetic association><genetic etiology><genetic mechanism of disease><genetic variant><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic variant><high risk><histories><improved><manage symptom><multidisciplinary><ocular dryness><ocular signs of dryness><ocular surface dryness><oral dryness><participant recruitment><pathophysiology><pathway><pre-clinical><preclinical><reconstruction><recruit><response><rheumatic arthritis><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><salivary gland hypofunction><scRNA sequencing><scRNA-seq><scale up><self reactive antibody><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell mRNA sequencing><single cell transcriptomic profiling><single-cell RNA sequencing><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><symptom management><systemic autoimmune disease><systemic autoimmune disorder><tear deficiency><therapeutic target><transcriptome sequencing><transcriptomic sequencing><validations><whole genome><whole genome association analysis><whole genome association study><xerodermosteosis>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

GUSTAVO Adolfo ANGARITA

YALE UNIVERSITY, NEW HAVEN, CT

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$708,497
FY 2025

Project Title

Aberrant Synaptic Plasticity in Cocaine Use Disorder: A 11C UCB J PET Study

Grant Number:

5R01DA052454-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2021

End Date:

4/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Abstract In seminal preclinical studies nearly 20 years ago, Robinson & Kolb [1, 2] demonstrated enduring changes in synaptic (dendritic spine) density in medial prefrontal cortex (mPFC) of rodents following behaviorally sensitizing regimens of cocaine. Their findings suggested a potentially importa...

Research Terms

<Abstinence><Active Follow-up><Admission><Admission activity><Affect><Age><Alcohol Drinking><Alcohol consumption><Animals><Anterior><Award><Basic Research><Basic Science><Behavior><Binding><Brain><Brain Nervous System><Chronic><Clinical><Cocaine><Cocaine Users><Cocaine use disorder><Data><Decision Making><Dendritic Spines><Development><Disease><Disorder><Drug abuse><Drug usage><Drugs><Encephalon><EtOH drinking><EtOH use><Exploratory/Developmental Grant><Exposure to><Frequencies><Glycoproteins><Hospitals><Hour><Human><Image><Impairment><Individual><Inpatients><Intoxication><Measures><Medial><Mediating><Medication><Modeling><Modern Man><Molecular Interaction><Monitor><Nerve Cells><Nerve Unit><Neural Cell><Neurobiology><Neurocognitive><Neurocyte><Neurons><Neurosciences Research><Out-patients><Outcome><Outpatients><PET><PET Scan><PET imaging><PETSCAN><PETT><Pattern><Performance><Pharmaceutical Preparations><Pilot Projects><Plague><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Prefrontal Cortex><Principal Investigator><Proteins><R21 Mechanism><R21 Program><Race><Races><Rad.-PET><Recurrence><Recurrent><Regimen><Regulation><Relapse><Rewards><Rodent><Rodentia><Rodents Mammals><Role><Sample Size><Scanning><Seminal><Specificity><Stimulant><Study Subject><Synapses><Synaptic><Synaptic Vesicles><Synaptic plasticity><Testing><Time><Toxicology><Translations><Urine><Yersinia pestis disease><abuse of drugs><abuses drugs><active followup><ages><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><behavioral sensitization><cingulate cortex><clinical translation><clinically translatable><cocaine use><cohort><craving><dendrite spine><density><design><designing><developmental><drug abstinence><drug craving><drug use><drug/agent><effective therapy><effective treatment><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><exploratory developmental study><follow up><follow-up><followed up><followup><imaging><neurobiological><neuronal><nicotine consumption><nicotine use><novel><pilot study><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><pre-clinical study><preclinical study><presynaptic><prolonged abstinence><racial><racial background><racial origin><radiolabel><radiolabels><radiotracer><sex><social role><sustained abstinence><synapse><synapse function><synaptic function><translation>
View Full Project Details on NIH Reporter
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MARC MOSS

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$634,798
FY 2025

Project Title

Aspiration in Acute Respiratory Failure Survivors

Grant Number:

5R01NR019989-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/23/2021

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT Each year more than 700,000 patients survive an episode of acute respiratory failure (ARF) that required endotracheal intubation with mechanical ventilation. Occurring in as many as 44% of these ARF survivors, post-extubation aspiration is associated with deleterious consequ...

Research Terms

<Acute respiratory failure><Admission><Admission activity><Algorithms><Boston><Breathing><Bryophyta><Bryophyte><Burden on their caregivers><Caregiver Burden><Classification><Cohort Studies><Colorado><Coloring Agents><Concurrent Studies><Confounding Factors (Epidemiology)><Confounding Variables><Critical Illness><Critically Ill><Decision Trees><Deglutition><Deglutition Disorders><Development><Diagnosis><Diagnostic tests><Diameter><Dyes><Dysfunction><Dysphagia><Endotracheal Intubation><Enteral Feeding><Epidemiologic Confounding Factor><Epidemiology><Evaluable><Evaluable Disease><Evaluation><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Fiber Optics><Focus Groups><Functional disorder><Funding><Gastrostomy tube><Health><Health Care Facility><Health Facilities><Hospital Mortality><Hydrogen Oxide><In-house Mortalities><Infrastructure><Inhospital Mortality><Intratracheal Intubation><Intubation><Journals><Laryngeal><Larynx><Larynx Head and Neck><Life><Long-Term Care><Magazine><Measures><Mechanical ventilation><Medicine><Methods><Mosses><New England><Northeastern United States><Nutrition><Oral><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Persons><Pharyngeal structure><Pharynx><Physiopathology><Pneumonia><Procedures><Process><Prospective Studies><QOL><Quality of life><R21 Award><Recovery><Research><Respiratory Aspiration><Respiratory Inspiration><Risk><Risk Factors><Screening procedure><Speech Pathologist><Structure><Survivors><Swallowing><Swallowing Disorders><Systematics><Testing><Therapeutic><Throat><Trachea><Trachea Proper><Tube><Universities><Water><Work><acute care><aspirate><burden in caregivers><burden of their caregivers><burden on caregivers><care facilities><care for patients><care of patients><caring for patients><cost><developmental><endotracheal><enteral feeding tube><enteric feeding><epidemiologic><epidemiological><extended care><feeding><feeding tube><g-tube><gastric feeding><gastric feeding tube><gastric tube><high risk><improved><infancy><infantile><innovate><innovation><innovative><inspiration><interest><malleable risk><mechanical respiratory assist><mechanically ventilated><modifiable risk><multidisciplinary><novel><pathophysiology><patient oriented outcomes><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pressure><prevent><preventing><prospective><screening><screening tools><screenings><speech language pathologist><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><tracheal intubation><tube feeding><ultrasound><voice box><windpipe>
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Jeremy Matthew Bono

UNIVERSITY OF ARIZONA, TUCSON, AZ

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$625,024
FY 2025

Project Title

Investigating a novel role of ejaculate RNA in fertility

Grant Number:

5R01HD112461-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/18/2023

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The male ejaculate of internally fertilizing organisms is a diverse mixture of components including sperm and numerous other macromolecules that are transferred to females during mating. Research on male contributions to fertility has mainly focused on sperm, and, more recently on pr...

Research Terms

<Area><Assay><Automobile Driving><Behavior><Bioassay><Biological Assay><Body Tissues><Cell Body><Cells><Complex><Copulation><Drosophila><Drosophila genus><Ejaculation><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Fecundability><Fecundity><Female><Fertility><Funding><Goals><Human><Immunity><Incidence><Individual><Insect Control><Insect Vectors><Insecta><Insects><Insects Invertebrates><Investigation><Life><Mammalia><Mammals><Mediating><Modern Man><Molecular><Non-Polyadenylated RNA><Organism><Partner in relationship><Play><Proteins><Proteomics><R21 Award><RNA><RNA Gene Products><Reporting><Reproduction><Reproductive Physiology><Research><Ribonucleic Acid><Role><Semen><Seminal fluid><Source><Sperm><Spermatozoa><System><Tissues><Transcript><Transfer RNA><Translating><Translations><Trees><Triplet Codon-Amino Acid Adaptor><Variant><Variation><Work><clinical significance><clinically significant><design><designing><driving><exosome><extracellular vesicles><female genital tract><female reproductive tract><fruit fly><human disease><human pathogen><idiopathic infertility><insight><interest><living system><macromolecule><male><mate><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><offspring><protein function><reproductive><reproductive outcome><response><sex><social role><sperm cell><tRNA><transfer Ribonucleic acids><translation><unexplained infertility><women's genital tract><women's reproductive tract><zoosperm><♀><♂>
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Luciano Matias Matzkin

UNIVERSITY OF ARIZONA, TUCSON, AZ

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$625,024
FY 2025

Project Title

Investigating a novel role of ejaculate RNA in fertility

Grant Number:

5R01HD112461-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/18/2023

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY The male ejaculate of internally fertilizing organisms is a diverse mixture of components including sperm and numerous other macromolecules that are transferred to females during mating. Research on male contributions to fertility has mainly focused on sperm, and, more recently on pr...

Research Terms

<Area><Assay><Automobile Driving><Behavior><Bioassay><Biological Assay><Body Tissues><Cell Body><Cells><Complex><Copulation><Drosophila><Drosophila genus><Ejaculation><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Fecundability><Fecundity><Female><Fertility><Funding><Goals><Human><Immunity><Incidence><Individual><Insect Control><Insect Vectors><Insecta><Insects><Insects Invertebrates><Investigation><Life><Mammalia><Mammals><Mediating><Modern Man><Molecular><Non-Polyadenylated RNA><Organism><Partner in relationship><Play><Proteins><Proteomics><R21 Award><RNA><RNA Gene Products><Reporting><Reproduction><Reproductive Physiology><Research><Ribonucleic Acid><Role><Semen><Seminal fluid><Source><Sperm><Spermatozoa><System><Tissues><Transcript><Transfer RNA><Translating><Translations><Trees><Triplet Codon-Amino Acid Adaptor><Variant><Variation><Work><clinical significance><clinically significant><design><designing><driving><exosome><extracellular vesicles><female genital tract><female reproductive tract><fruit fly><human disease><human pathogen><idiopathic infertility><insight><interest><living system><macromolecule><male><mate><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><offspring><protein function><reproductive><reproductive outcome><response><sex><social role><sperm cell><tRNA><transfer Ribonucleic acids><translation><unexplained infertility><women's genital tract><women's reproductive tract><zoosperm><♀><♂>
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Karen G. Martinez Gonzalez

UNIVERSITY OF PUERTO RICO MED SCIENCES, SAN JUAN, PR

Good lead · 52/100
Training-friendly
Above-average budget
Active award
$516,903
FY 2026

Project Title

Clinical and Translational Research Education and Career Development at the University of Puerto Rico (CRECD-UPR)

Grant Number:

5R25MD007607-24

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/24/2002

End Date:

12/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award size is strong enough to merit immediate review.

Project Abstract

The Clinical and Translational Research Education and Career Development at the University of Puerto Rico (CRECD-UPR) program at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) has a documented track record of increasing the workforce in clinical and translational research on health ...

Research Terms

<AIDS/HIV><Address><Admission><Admission activity><Area><Audiology><Award><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Clinic><Clinical><Clinical Research><Clinical Sciences><Clinical Study><Collaborations><Curriculum><Decrease health disparities><Dental><Dentistry><Development Plans><Diabetes Mellitus><Discipline><Discipline of Nursing><Education><Educational Curriculum><Educational aspects><Enrollment><Ensure><Funding><Goals><Grant><HIV/AIDS><Health><Health Care Professional><Health Disparities Research><Health Professional><Health disparities related research><Health disparity mitigation><Health disparity reduction><Infant><Infrastructure><Institution><Intervention><Investigators><Justice><K-Awards><K-Series Research Career Programs><Knowledge><Leadership><Learning><Lower health disparities><Malignant Neoplasms><Malignant Tumor><Master of Science><Master's Degree><Maternal Health><Medical><Medicine><Mental Health><Mental Hygiene><Mentors><Mentorship><Methodology><Mitigate health disparities><NIH><National Institutes of Health><Nursing><Nursing Field><Nursing Profession><Occupational Therapy><Oral health><Outcome><Peer Review><Pharmacies><Pharmacy facility><Pilot Projects><Population><Postdoc><Postdoctoral Fellow><Productivity><Program Evaluation><Psychological Health><Psychology><Publications><Publishing><Puerto Rico><Qualifying><Reduce health disparities><Research><Research Associate><Research Career Program><Research Personnel><Research Support><Research Training><Researchers><Science><Scientific Publication><Scientist><Structure><Training><Training Activity><Training Programs><Translational Research><Translational Science><United States National Institutes of Health><Universities><Work><academic program><career development><clinical development><dental health><diabetes><disparity in health><education research><enroll><expectation><experience><health disparities science><health disparity><health training><improved><innovate><innovation><innovative><lesson plans><malignancy><meeting><meetings><neoplasm/cancer><next generation><novel><patient oriented research><patient oriented study><pilot study><population health><post-doc><post-doctoral><post-doctoral trainee><precision medicine><precision-based medicine><programs><recruit><research associates><skills><success><timeline><training module><translation research><translational investigation><translational investigator><translational researcher><translational scientist>
View Full Project Details on NIH Reporter
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Barbara Segarra-Vazquez

UNIVERSITY OF PUERTO RICO MED SCIENCES, SAN JUAN, PR

Good lead · 52/100
Training-friendly
Above-average budget
Active award
$516,903
FY 2026

Project Title

Clinical and Translational Research Education and Career Development at the University of Puerto Rico (CRECD-UPR)

Grant Number:

5R25MD007607-24

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/24/2002

End Date:

12/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award size is strong enough to merit immediate review.

Project Abstract

The Clinical and Translational Research Education and Career Development at the University of Puerto Rico (CRECD-UPR) program at the University of Puerto Rico Medical Sciences Campus (UPR-MSC) has a documented track record of increasing the workforce in clinical and translational research on health ...

Research Terms

<AIDS/HIV><Address><Admission><Admission activity><Area><Audiology><Award><Cancers><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Clinic><Clinical><Clinical Research><Clinical Sciences><Clinical Study><Collaborations><Curriculum><Decrease health disparities><Dental><Dentistry><Development Plans><Diabetes Mellitus><Discipline><Discipline of Nursing><Education><Educational Curriculum><Educational aspects><Enrollment><Ensure><Funding><Goals><Grant><HIV/AIDS><Health><Health Care Professional><Health Disparities Research><Health Professional><Health disparities related research><Health disparity mitigation><Health disparity reduction><Infant><Infrastructure><Institution><Intervention><Investigators><Justice><K-Awards><K-Series Research Career Programs><Knowledge><Leadership><Learning><Lower health disparities><Malignant Neoplasms><Malignant Tumor><Master of Science><Master's Degree><Maternal Health><Medical><Medicine><Mental Health><Mental Hygiene><Mentors><Mentorship><Methodology><Mitigate health disparities><NIH><National Institutes of Health><Nursing><Nursing Field><Nursing Profession><Occupational Therapy><Oral health><Outcome><Peer Review><Pharmacies><Pharmacy facility><Pilot Projects><Population><Postdoc><Postdoctoral Fellow><Productivity><Program Evaluation><Psychological Health><Psychology><Publications><Publishing><Puerto Rico><Qualifying><Reduce health disparities><Research><Research Associate><Research Career Program><Research Personnel><Research Support><Research Training><Researchers><Science><Scientific Publication><Scientist><Structure><Training><Training Activity><Training Programs><Translational Research><Translational Science><United States National Institutes of Health><Universities><Work><academic program><career development><clinical development><dental health><diabetes><disparity in health><education research><enroll><expectation><experience><health disparities science><health disparity><health training><improved><innovate><innovation><innovative><lesson plans><malignancy><meeting><meetings><neoplasm/cancer><next generation><novel><patient oriented research><patient oriented study><pilot study><population health><post-doc><post-doctoral><post-doctoral trainee><precision medicine><precision-based medicine><programs><recruit><research associates><skills><success><timeline><training module><translation research><translational investigation><translational investigator><translational researcher><translational scientist>
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Han-Xiang Deng

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Good lead · 52/100
Likely hiring
Solid budget
Active award
$467,710
FY 2026

Project Title

Mouse model studies of TMEM230-linked Parkinson's disease

Grant Number:

5R01NS099623-10

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2016

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Through our previous work funded by the American Parkinson Disease Association and NINDS, we have discovered a new Parkinson’s disease (PD) genetic locus on the short arm of chromosome 20, and identified a new PD gene, TMEM230. TMEM230 encodes a transmembrane protein of secretory and recycling vesic...

Research Terms

<2 year old><2 years of age><20p><AP-2 Adaptor (Clathrin-Coated Vesicles)><AP-2 Protein Complex><Adaptor Protein Complex 2><Adaptor-Related Protein Complex 2><Address><Affect><Age Months><American><Auxilin><Auxilins><Binding><Binding Proteins><Biochemical><Biogenesis><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Chromosome 20><Chromosome 20 Proximal Arm><Chromosome 20 Short Arm><Clathrin><Clathrin Adaptor Protein Complex 2><Clathrin Assembly Protein Complex 2><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cyclicity><DNA><DNA mutation><Data><Defect><Deoxyribonucleic Acid><Development><Disease><Disorder><Dopamine><Dysfunction><Endocytosis><Endosomes><Exocytosis><Exploratory/Developmental Grant><Family><Functional disorder><Functional impairment><Funding><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Goals><HA-2 Adaptors><Human><Hydroxyapatite 2 Adaptors><Hydroxytyramine><Impairment><Individual><Integral Membrane Protein><Intrinsic Membrane Protein><Isoforms><KI mice><KO mice><Knock-in Mouse><Knock-out Mice><Knockout Mice><LRRK2><LRRK2 gene><LRRK2 leucine-rich repeat kinase 2 gene><LRRK2 protein><LacZ><LacZ Genes><Ligand Binding Protein><Ligand Binding Protein Gene><Link><Maps><Measures><Mediating><Mice><Mice Mammals><Missense Mutation><Modeling><Modern Man><Modification><Molecular><Molecular Interaction><Murine><Mus><Mutation><N-terminal><NH2-terminal><NIH><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neural Transmission><Neurocyte><Neuronal Transmission><Neurons><Null Mouse><Origin of Life><Outcome Study><PARK20><PARK8 protein><Paralysis Agitans><Parkinson><Parkinson Disease><Parkinson disease 8 protein><Pathogenesis><Pathogenicity><Pathologic><Pathology><Pathway interactions><Periodicity><Phenotype><Physiologic><Physiological><Physiopathology><Play><Primary Parkinsonism><Process><Property><Protein Binding><Protein Isoforms><Protein Trafficking><Proteins><R21 Mechanism><R21 Program><Receptosomes><Recycling><Research Resources><Resources><Retrieval><Rhythmicity><Role><SYNJ1><SYNJ1 gene><Sampling><Scanning><Series><Site><Sorting><Stimulus><Study models><Synaptic Membranes><Synaptic Transmission><Synaptic Vesicles><Testing><Time><Transgenic Mice><Transmembrane Protein><Transmembrane Protein Gene><United States National Institutes of Health><Vesicle><Work><age 2><age 2 years><aged 2 years><aged two years><axon signaling><axon-glial signaling><axonal signaling><bound protein><dardarin><dardarin gene><dardarin protein><design><designing><developmental><exome sequencing><exome-seq><exploratory developmental study><gene locus><genetic locus><genome mutation><genomic location><genomic locus><glia signaling><glial signaling><knockin mice><leucine-rich repeat kinase 2><member><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><motor deficit><mouse model><murine model><nerve signaling><neural signaling><neuronal><neuronal signaling><neurophysiological><neurophysiology><neurotransmission><nigrostriatal pathway><pathophysiology><pathway><presynaptic><protein transport><screening><screenings><secretory protein><social role><sporadic Parkinson's Disease><synaptojanin><synaptojanin-1><synaptojanin1><therapeutic agent development><therapeutic development><trafficking><two year old><two years of age>
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RUI-MING LIU

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Good lead · 52/100
Likely hiring
Solid budget
Active award
$441,440
FY 2026

Project Title

Sex-dependent synergy between O3 exposure, APOE4 e4 genotype, and aging in the onset of Alzheimer's disease

Grant Number:

5R01AG077395-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

11/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

The etiology for late-onset Alzheimer’s disease (LOAD), which accounts for >95% of AD cases, is unknown. Aging is the greatest risk factor for LOAD, whereas APOE4 is believed to be a major genetic risk factor in acquiring LOAD, with female APOE4 carriers at the greatest risk. Yet, not all of APOE...

Research Terms

<AD dementia><AD therapy><AD treatment><APOE><APOE e3><APOE e4><APOE-ε4><APOEε4><Address><Affect><Age><Aging><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer disease treatment><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer treatment><Alzheimer's><Alzheimer's Disease><Alzheimer's disease therapy><Alzheimer's therapy><Alzheimers Dementia><Antioxidants><Apo-E><ApoE protein><Apolipoprotein E><Blood Plasma><Brain><Brain Nervous System><Budgets><Causality><Complex><Cyclicity><Data><Development><Dietary Supplementation><Differences between sexes><Differs between sexes><Disease><Disorder><Dysfunction><Elderly><Encephalon><Environmental Exposure><Environmental Factor><Environmental Risk Factor><Environmental Toxin><Estrogens><Etiology><Exhibits><Exposure to><Female><Functional disorder><Genetic predisposing factor><Genotype><Human><Hydroquinones><Incidence><Late Onset Alzheimer Disease><Late onset AD><Memory Deficit><Memory Loss><Memory impairment><Mice><Mice Mammals><Modern Man><Modification><Molecular><Murine><Mus><NF-E2 protein><NF-E2 transcription factor><NFE2 protein><O3><O3 exposure><Oxidants><Oxidative Stress><Oxidizing Agents><Ozone><Periodicity><Physiopathology><Plasma><Plasma Serum><Play><Population><Predisposition><Preventative strategy><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Proteins><Protocol><Protocols documentation><Quinols><Resistance><Reticuloendothelial System, Serum, Plasma><Rhythmicity><Risk><Risk Factors><Role><Sex Differences><Sexual differences><Susceptibility><Testing><Therapeutic Estrogen><Time><Toxic Environmental Agents><Toxic Environmental Substances><Toxic effect><Toxicities><advanced age><ages><air filter><anti-oxidant enzyme><antioxidant enzyme><apo E-3><apo E-4><apo E3><apo E4><apo epsilon4><apoE epsilon 4><apoE-3><apoE-4><apoE3><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-3><apolipoprotein E-4><apolipoprotein E3><apolipoprotein E4><causation><developmental><diet supplementation><disease causation><disease model><disorder model><electron acceptor><environmental risk><environmental toxicant><epidemiology research study><epidemiology study><epidemiology survey><exposed human population><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><genetic risk factor><geriatric><high risk><human exposure><inherited factor><insight><late onset alzheimer><male><memory decline><memory dysfunction><neural inflammation><neuroinflammation><neuroinflammatory><neuron toxicity><neuronal toxicity><neurotoxicity><new approaches><novel><novel approaches><novel strategies><novel strategy><nuclear factor-erythroid 2><oxidation><ozone exposure><p-Dihydroxybenzenes><para-Dihydroxybenzenes><pathophysiology><pollutant><primary degenerative dementia><resistant><response><restoration><senile dementia of the Alzheimer type><senior citizen><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><synergism><toxicant><♀><♂>
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James Beeson

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$332,850
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

3R01AI182232-02S2

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
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SURYARAM GUMMULURU

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$332,850
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

3R01AI182232-02S2

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Don P Mathanga

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$332,850
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

3R01AI182232-02S2

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Clarissa Valim

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$332,850
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

3R01AI182232-02S2

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

James Beeson

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$270,248
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

5R01AI182232-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/6/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

SURYARAM GUMMULURU

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$270,248
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

5R01AI182232-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/6/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Don P Mathanga

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$270,248
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

5R01AI182232-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/6/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Clarissa Valim

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Good lead · 52/100
Likely hiring
Solid budget
Active award
$270,248
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

5R01AI182232-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/6/2024

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Benjamin J Kopecky

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 48/100
Above-average budget
Very recent
Active award
$624,000
FY 2026

Project Title

Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane

Grant Number:

1R21EB038487-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract According to the organ procurement and transplantation network, every year more than 40,000 organs are transplanted in the United States; from those organs, over 4500 are related to heart transplantation. Two main limitations that exist with heart transplantation are #1: the...

Research Terms

<Acute><Artificial nano particles><Artificial nanoparticles><Assay><Award><Back><Bioassay><Biological Assay><Biology><Biomanufacturing><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood monocyte><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><CCL2><CCL2 gene><Cancers><Cardiac><Cardiac Transplantation><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cell surface><Cells><Cessation of life><Chemical Engineering><Chemokine, CC Motif, Ligand 2><Chronic><Clinical><Co-culture><Cocultivation><Coculture><Coculture Techniques><Death><Dorsum><Drug Delivery><Drug Delivery Systems><Drug Therapy><Drugs><Dysfunction><Engineering><Ensure><Failure><Fibroblasts><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional disorder><Funding Opportunities><Future><Generations><Goals><Grafting Procedure><Grant><Heart><Heart Grafting><Heart Transplantation><Heart failure><Human><Human Figure><Human body><Immune><Immunes><Immunofluorescence><Immunofluorescence Immunologic><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><In Vitro><Inflammation><Inflammatory><Intellectual Property><Intervention><Intracellular Communication and Signaling><Investigators><MCAF><MCP-1><MCP1><Macrophage><Macrophage Activation><Malignant Neoplasms><Malignant Tumor><Marrow Neutrophil><Marrow monocyte><Medication><Membrane><Mice><Mice Mammals><Modern Man><Monocyte Chemoattractant Protein-1><Monocyte Chemotactic Protein-1><Monocyte Chemotactic and Activating Factor><Monocyte Chemotactic and Activating Protein><Monocyte Chemotactive and Activating Factor><Monocyte Secretory Protein JE><Murine><Mus><Mφ><Nanotechnology><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Organ><Organ Donor><Organ Procurements><Organ Transplantation><Organ Transplants><Outcome><Patients><Peptides><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Physicians><Physiopathology><Polymers><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Research><Research Personnel><Researchers><Risk><SCYA2><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Small Inducible Cytokine A2><Solid><Specificity><System><Technology><Testing><Therapeutic><Therapeutic Intervention><Time><Tissues><Topical Drug Administration><Topical application><Translating><Transplantation><Transplantation Tolerance><United States><Waiting Lists><apply topically><biocompatibility><biological signal transduction><biomaterial compatibility><burden of infection><cancer type><cardiac failure><cardiac graft><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><deliver topically><design><designing><drug intervention><drug treatment><drug/agent><efficacy testing><end-stage organ failure><engineered nano particle><engineered nanoparticle><experience><flow cytophotometry><heart transplant><high risk><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressive activity><immunosuppressive function><immunosuppressive response><implantation><improved><improved outcome><in vivo><infection burden><inhibitor><innovate><innovation><innovative><intervention therapy><invention><malignancy><materials science><membrane structure><monocyte><mortality><mouse model><murine model><nano particle><nano tech><nano technology><nano-sized particle><nano-technological><nanoparticle><nanosized particle><nanotech><nanotechnological><neoplasm/cancer><neutrophil><novel><organ allograft><organ graft><organ procurement transplantation network><organ xenograft><pathophysiology><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><polymer><polymeric><post-transplant><post-transplantation><posttransplant><posttransplantation><recruit><repurposing><success><topical administration><topical delivery><topical drug application><topical drug delivery><topical instillation><topical treatment><transplant><treat topically><waitlist>
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Brisa Marisol Pena Castellanos

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 48/100
Above-average budget
Very recent
Active award
$624,000
FY 2026

Project Title

Leveraging targeted cell therapy to promote heart transplant tolerance through topical application of a nanoparticle infused polymeric membrane

Grant Number:

1R21EB038487-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.
  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract According to the organ procurement and transplantation network, every year more than 40,000 organs are transplanted in the United States; from those organs, over 4500 are related to heart transplantation. Two main limitations that exist with heart transplantation are #1: the...

Research Terms

<Acute><Artificial nano particles><Artificial nanoparticles><Assay><Award><Back><Bioassay><Biological Assay><Biology><Biomanufacturing><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood monocyte><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><CCL2><CCL2 gene><Cancers><Cardiac><Cardiac Transplantation><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cell surface><Cells><Cessation of life><Chemical Engineering><Chemokine, CC Motif, Ligand 2><Chronic><Clinical><Co-culture><Cocultivation><Coculture><Coculture Techniques><Death><Dorsum><Drug Delivery><Drug Delivery Systems><Drug Therapy><Drugs><Dysfunction><Engineering><Ensure><Failure><Fibroblasts><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional disorder><Funding Opportunities><Future><Generations><Goals><Grafting Procedure><Grant><Heart><Heart Grafting><Heart Transplantation><Heart failure><Human><Human Figure><Human body><Immune><Immunes><Immunofluorescence><Immunofluorescence Immunologic><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><In Vitro><Inflammation><Inflammatory><Intellectual Property><Intervention><Intracellular Communication and Signaling><Investigators><MCAF><MCP-1><MCP1><Macrophage><Macrophage Activation><Malignant Neoplasms><Malignant Tumor><Marrow Neutrophil><Marrow monocyte><Medication><Membrane><Mice><Mice Mammals><Modern Man><Monocyte Chemoattractant Protein-1><Monocyte Chemotactic Protein-1><Monocyte Chemotactic and Activating Factor><Monocyte Chemotactic and Activating Protein><Monocyte Chemotactive and Activating Factor><Monocyte Secretory Protein JE><Murine><Mus><Mφ><Nanotechnology><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Organ><Organ Donor><Organ Procurements><Organ Transplantation><Organ Transplants><Outcome><Patients><Peptides><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Physicians><Physiopathology><Polymers><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Research><Research Personnel><Researchers><Risk><SCYA2><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Small Inducible Cytokine A2><Solid><Specificity><System><Technology><Testing><Therapeutic><Therapeutic Intervention><Time><Tissues><Topical Drug Administration><Topical application><Translating><Transplantation><Transplantation Tolerance><United States><Waiting Lists><apply topically><biocompatibility><biological signal transduction><biomaterial compatibility><burden of infection><cancer type><cardiac failure><cardiac graft><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><deliver topically><design><designing><drug intervention><drug treatment><drug/agent><efficacy testing><end-stage organ failure><engineered nano particle><engineered nanoparticle><experience><flow cytophotometry><heart transplant><high risk><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressive activity><immunosuppressive function><immunosuppressive response><implantation><improved><improved outcome><in vivo><infection burden><inhibitor><innovate><innovation><innovative><intervention therapy><invention><malignancy><materials science><membrane structure><monocyte><mortality><mouse model><murine model><nano particle><nano tech><nano technology><nano-sized particle><nano-technological><nanoparticle><nanosized particle><nanotech><nanotechnological><neoplasm/cancer><neutrophil><novel><organ allograft><organ graft><organ procurement transplantation network><organ xenograft><pathophysiology><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><polymer><polymeric><post-transplant><post-transplantation><posttransplant><posttransplantation><recruit><repurposing><success><topical administration><topical delivery><topical drug application><topical drug delivery><topical instillation><topical treatment><transplant><treat topically><waitlist>
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Dongkeun Park

MASSACHUSETTS INSTITUTE OF TECHNOLOGY, CAMBRIDGE, MA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$389,170
FY 2025

Project Title

A Benchtop Cryogen-Free 23.5-T/25-mm-RT-Bore Magnet for 1-GHz microcoil NMR Spectroscopy

Grant Number:

5R01GM147794-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/23/2022

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary In this project we propose to develop a benchtop cryogen-free 23.5-T high-temperature superconducting (HTS) magnet for 1-GHz microcoil nuclear magnetic resonance (NMR) spectroscopy. Higher-field magnet offers better resolution and sensitivity, enabling analysis of larger molecules li...

Research Terms

<Adopted><Age><Charge><Communities><Copper><Cu element><Development><Diameter><Exploratory/Developmental Grant><Fe element><Frequencies><Funding><Future><He element><Helium><High temperature of physical object><Iron><Lead><Leanness><Length><Liquid substance><Mechanics><Methods><NMR Spectrometer><NMR Spectroscopy><Nuclear Magnetic Resonance><Pb element><R-Series Research Projects><R01 Mechanism><R01 Program><R21 Mechanism><R21 Program><Radial><Radius><Research><Research Grants><Research Project Grants><Research Projects><Research Resources><Resolution><Resources><Science><Site><Source><Specific qualifier value><Specified><Stress><System><Techniques><Technology><Temperature><Thinness><Work><ages><cost><cost effective><cryogenics><design><designing><developmental><exploratory developmental study><fluid><heavy metal Pb><heavy metal lead><high temperature><innovate><innovation><innovative><liquid><manufacturing process><mechanic><mechanical><next generation><nuclear magnetic resonance spectroscopy><operation><operations><programs><protein complex><prototype><resolutions><screening><screenings><structural biology><superconductivity><tool>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Matthias Johannes Schnell

THOMAS JEFFERSON UNIVERSITY, PHILADELPHIA, PA

Good lead · 46/100
Likely hiring
Solid budget
Active award
$378,300
FY 2025

Project Title

Pan-lyssavirus therapeutics and mechanisms of protection against lyssaviruses

Grant Number:

5R01AI149795-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2020

End Date:

12/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Abstract Rabies disease is nearly 100% lethal in the absence of treatment, killing an estimated 59,000 people annually. When vaccines are properly administered, they are highly efficacious, making them one of the most economically high-impact interventions among infectious diseases. About 30,000 peo...

Research Terms

<Ab-dependent cellular cytotoxicity><Ab-mediated immunity><Ab-mediated protection><Address><Animals><Antibodies><Antibody immunity><Antibody protection><Antibody-mediated protection><Applications Grants><Assay><Bats><Bioassay><Biological Agent><Biological Assay><Biological Products><Blood Serum><Chiroptera><Clinical Treatment Moab><Communicable Diseases><Competitive Binding><Complement><Complement Proteins><Cytotoxic cell><DNA mutation><Data><Disease><Disease Outbreaks><Disorder><ELISA><Enzyme-Linked Immunosorbent Assay><Epitope Mapping><Escape Mutant><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Funding><Generations><Genetic Change><Genetic defect><Genetic mutation><Glycoproteins><Goals><Grant Proposals><Harvest><Human><Hybridomas><Immune response><Immunity><Immunize><Infection><Infectious Diseases><Infectious Disorder><Intervention><K lymphocyte><Knowledge><Lyssavirus><MOKV><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Mokola virus><Monoclonal Antibodies><Murine><Mus><Mutation><NK Cells><Natural Killer Cells><Outbreaks><Pathway interactions><Persons><Phagocytosis><Property><R21 Award><Rabies><Rabies lyssavirus><Rabies virus><Recombinants><Serum><Spleen><Spleen Reticuloendothelial System><Suggestion><Testing><Therapeutic><Transgenic Mice><Vaccinated><Vaccines><Viral><Virus><Visit><antibody dependent cell mediated cytotoxicity><antibody dependent cytotoxicity><antibody mediated cellular cytotoxicity><antibody-dependent cell cytotoxicity><antibody-dependent cellular cytotoxicity><antibody-mediated cytotoxicity><antibody-mediated immunity><biologics><biopharmaceutical><biotherapeutic agent><competitively bound><complementation><cross reactivity><design><designing><enzyme linked immunoassay><genome mutation><host response><immune system response><immunogenicity><immunoresponse><in vivo><lyssa><mAbs><monoclonal Abs><neutralizing antibody><neutralizing mAb><neutralizing monoclonal antibodies><novel><pathway><receptor binding><receptor bound><response><seroconversion>
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Shankar Subramaniam

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 42/100
Large award
Active award
Team-scale grant
$1,399,999
FY 2025

Project Title

Metabolomics Workbench - National Metabolomics Data Repository

Grant Number:

5U24DK141185-02

Activity Code:

U24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/20/2024

End Date:

6/30/2029

Why this may be worth a closer look

  • • Large budget suggests more room for personnel or project growth.

Project Abstract

PROJECT SUMMARY/ABSTRACT The Metabolomics Workbench (MW) – National Metabolomics Data Repository (NMDR) is a unique data resource that serves the biomedical research community. It was started through the NIH Common Fund Metabolomics Initiative over a decade ago and has developed into a one-of-its-ki...

Research Terms

<Biological><Biomedical Research><Blood><Blood Reticuloendothelial System><Body Fluids><Body Tissues><Cell Body><Cell model><Cells><Cellular model><Classification><Clinical><Clinical Research><Clinical Study><Cohort Studies><Communities><Companions><Complex><Computers><Concurrent Studies><Country><Data><Data Banks><Data Bases><Data Discovery><Data Set><Databanks><Databases><Deposit><Deposition><Disease><Disorder><Dysfunction><Evolution><Exploratory/Developmental Grant><FHIR><Fast Health Care Interoperability Resources><Feedback><Friends><Functional disorder><Funding><Generalized Growth><Genotype><Graph><Growth><Home><Human><Infrastructure><Ingestion><International><Investigators><Learning><Maintenance><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measurement><Measures><Metabolic><Metadata><Methods><Modeling><Modern Man><Motivation><NIH><National Institutes of Health><Phenotype><Physiology><Physiopathology><Process><R-Series Research Projects><R01 Mechanism><R01 Program><R21 Mechanism><R21 Program><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Sampling><Scheme><Services><Source><Specific qualifier value><Specified><System><Systematics><Systems Biology><Technology><Tissue Growth><Tissues><United States National Institutes of Health><Update><Visual><Visualization><annotation system><annotation framework><annotation tool><biologic><biomedical resource><cohort><data access><data base><data base structure><data deposition><data depository><data harmonization><data infrastructure><data repository><data resource><data set repository><data submission><database structure><dataset repository><depository><experience><exploratory developmental study><genetic make-up><genetic makeup><genomic data><genomic dataset><graph database><harmonized data><homes><human subject><improved><ingest><interoperability><knowledge graph><large scale data><large scale data sets><large scale datasets><meta data><metabolic phenotype><metabolism measurement><metabolome><metabolomics><metabolomics resource><metabonome><metabonomics><metabotype><ontogeny><outreach><pathophysiology><relational database><repository><skills><supercomputer><tool><usability>
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James Beeson

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Exploratory lead · 42/100
Likely hiring
Active award
$26,142
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

3R01AI182232-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
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SURYARAM GUMMULURU

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Exploratory lead · 42/100
Likely hiring
Active award
$26,142
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

3R01AI182232-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
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Don P Mathanga

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Exploratory lead · 42/100
Likely hiring
Active award
$26,142
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

3R01AI182232-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
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Clarissa Valim

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Exploratory lead · 42/100
Likely hiring
Active award
$26,142
FY 2026

Project Title

Determinants of poor responsiveness to the booster dose of the RTS,S malaria vaccine in African children

Grant Number:

3R01AI182232-02S1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2025

End Date:

11/30/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Implementation of the RTS,S malaria vaccine in sub Saharan Africa has been recommended by the WHO and UNICEF has pledged $170 million for production of the first vaccine supply. Because the efficacy of RTS,S wanes within one year from the primary doses, the regimen includes a 4th boo...

Research Terms

<0-11 years old><Adjuvant><Affect><Africa South of the Sahara><African><Age><Animals><Antibodies><Antibody Response><Antigens><Area><Attenuated><Attenuated Vaccines><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Blood><Blood Reticuloendothelial System><Blood monocyte><Breast Feeding><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Chemoprophylaxis><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Country><Data><Dose><Epidemiology><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exclusive Breastfeeding><Exposure to><Fe deficiency><Fe element><Frequencies><Glycans><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Immune><Immune memory><Immune response><Immunes><Immunity><Immunochemical Immunologic><Immunologic><Immunologic Memory><Immunological><Immunological Memory><Immunologically><Immunologics><Impairment><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammatory Response><Innate Immune Response><Iron><Length of Life><Life><Live-attenuated Vaccine><Longevity><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marrow monocyte><Memory><Memory B Cell><Memory B-Lymphocyte><Memory Deficit><Memory impairment><Metabolic><Nyasaland><Paludism><Parasites><Phenotype><Plasmodium Infections><Polysaccharides><Population><Production><Recommendation><Regimen><Regulatory T-Lymphocyte><Role><S Period><S phase><Site><Sub-Saharan Africa><Subsaharan Africa><Synthesis Period><Synthesis Phase><T memory cell><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Time><Treg><UNICEF><Vaccination><Vaccine Adjuvant><Vaccines><Zinc><Zinc decreased><Zinc deficiency><Zinc low><Zn deficiency><Zn element><Zn levels low><Zn++ low><ages><anamnestic reaction><attenuate><attenuates><barriers to implementation><booster dose><booster shot><booster vaccine><cohort><design><designing><epidemiologic><epidemiological><epidemiology research study><epidemiology study><epidemiology survey><epigenetically><future implementation><host response><immune system response><immunogen><immunoresponse><implementation barriers><implementation challenges><implementation study><iron deficiency><kids><live vaccine><live vaccines><low Zinc level><malaria infection><malaria transmission><malaria-infected><malarial infection><memory T lymphocyte><memory dysfunction><micronutrient deficiency><monocyte><pediatric><phase 3 trial><phase III trial><programs><regulatory T-cells><response><secondary immune response><social role><thymus derived lymphocyte><vaccine antibodies><vaccine boost><vaccine candidate><vaccine efficacy><vaccine induced antibodies><vaccine response><vaccine responsiveness><vaccine-induced antibodies><vaccine-induced response><vaccines against malaria><youngster>
View Full Project Details on NIH Reporter
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Pei-Yu Chen

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$455,604
FY 2026

Project Title

Developing unique anti-EndMT nanoparticle therapy for cardiovascular disease

Grant Number:

1R21TR005519-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Vascular diseases driven by endothelial dysfunction represent a major therapeutic challenge due to the lack of cell-specific delivery systems. While TGFβ-driven endothelial-to-mesenchymal transition (EndMT) has emerged as a key therapeutic target, current approaches are limited by of...

Research Terms

<2019-nCoV vaccine><APOE><Acceleration><Address><Affect><American><Apo-E><ApoE protein><Apolipoprotein E><Biodistribution><Blood Diseases><Blood Vessels><Body Tissues><Bone-Derived Transforming Growth Factor><COVID-19 vaccine><Cardiovascular Diseases><Cell Body><Cells><Clinical Chemistry><Competitive Binding><Complex><Data><Dependence><Development><Dose><Dose Limiting><Drug Kinetics><Dysfunction><Encapsulated><Endothelial Cells><Endothelium><Engineering><Ensure><Evaluation><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Formulation><Foundations><Functional disorder><HDL><HDL Lipoproteins><Heavy Lipoproteins><Hematologic Diseases><Hematological Disease><Hematological Disorder><High Density Lipoproteins><Histologic><Histologically><Histopathology><Image Cytometry><Inflammatory Response><Investigation><Life><Ligands><Lineage Tracing><Lipids><Liver><Mediating><Mesenchymal><Mice><Mice Mammals><Milk Growth Factor><Modeling><Modification><Molecular Analysis><Murine><Mus><NCATS><National Center for Advancing Translational Sciences><Non-Polyadenylated RNA><Palsy><Paralysed><Particle Size><Patients><Pharmacokinetics><Phase><Physiopathology><Platelet Transforming Growth Factor><Play><Plegia><Process><Production><Pulmonary Hypertension><Quality Control><RNA><RNA Gene Products><RNA based therapeutics><RNA based therapy><RNA delivery><RNA targeting drug><RNA targeting therapeutics><RNA therapy><RNA-targeting therapy><Reproducibility><Ribonucleic Acid><Role><SARS-CoV-2 vaccine><SARS-coronavirus-2 vaccine><Safety><Severe Acute Respiratory Syndrome CoV 2 vaccine><Severe acute respiratory syndrome coronavirus 2 vaccine><Signal Pathway><Specificity><Standardization><System><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Technology><Therapeutic><Therapeutic Effect><Tissues><Toxic effect><Toxicities><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Treatment Efficacy><Validation><Vascular Diseases><Vascular Disorder><Vascular Endothelium><alpha-Lipoproteins><analytical method><blood disorder><blood vessel disorder><cardiovascular disease therapy><cardiovascular disorder><cardiovascular disorder therapy><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><clinical development><clinical translation><clinically translatable><cohort><competitively bound><coronavirus disease 2019 vaccine><coronavirus disease-19 vaccine><design><design validation><design verification><designing><developmental><endothelial dysfunction><flow cytophotometry><health care burden><hemodynamics><hepatic body system><hepatic organ system><hypoxia-induced pulmonary hypertension><hypoxic pulmonary hypertension><indexing><innovate><innovation><innovative><intervention efficacy><lipid based nanoparticle><lipid nanoparticle><manufacture><manufacturing process><nCoV vaccine><nCoV-19 vaccine><nCoV19 vaccine><nano particle delivery><nanoparticle delivered><nanoparticle delivery><nanoparticle therapy><novel><paralysis><paralytic><particle><pathophysiology><pulmonary><quantum><response><safety assessment><sex><social role><success><technology platform><technology system><therapeutic RNA><therapeutic efficacy><therapeutic nanoparticles><therapeutic outcome><therapeutic target><therapy efficacy><therapy outcome><uptake><vaccine against 2019-nCov><vaccine against COVID-19><vaccine against SARS-CoV-2><vaccine against SARS-coronavirus-2><vaccine against Severe Acute Respiratory Syndrome CoV 2><vaccine against Severe acute respiratory syndrome coronavirus 2><vaccine candidates against SARS-CoV-2><vaccine for novel coronavirus><vaccines preventing COVID><vaccines to prevent COVID><validation studies><validations><vascular><vascular bed><vascular dysfunction><vasculopathy><zeta potential>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Lingfeng Qin

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$455,604
FY 2026

Project Title

Developing unique anti-EndMT nanoparticle therapy for cardiovascular disease

Grant Number:

1R21TR005519-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Vascular diseases driven by endothelial dysfunction represent a major therapeutic challenge due to the lack of cell-specific delivery systems. While TGFβ-driven endothelial-to-mesenchymal transition (EndMT) has emerged as a key therapeutic target, current approaches are limited by of...

Research Terms

<2019-nCoV vaccine><APOE><Acceleration><Address><Affect><American><Apo-E><ApoE protein><Apolipoprotein E><Biodistribution><Blood Diseases><Blood Vessels><Body Tissues><Bone-Derived Transforming Growth Factor><COVID-19 vaccine><Cardiovascular Diseases><Cell Body><Cells><Clinical Chemistry><Competitive Binding><Complex><Data><Dependence><Development><Dose><Dose Limiting><Drug Kinetics><Dysfunction><Encapsulated><Endothelial Cells><Endothelium><Engineering><Ensure><Evaluation><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Formulation><Foundations><Functional disorder><HDL><HDL Lipoproteins><Heavy Lipoproteins><Hematologic Diseases><Hematological Disease><Hematological Disorder><High Density Lipoproteins><Histologic><Histologically><Histopathology><Image Cytometry><Inflammatory Response><Investigation><Life><Ligands><Lineage Tracing><Lipids><Liver><Mediating><Mesenchymal><Mice><Mice Mammals><Milk Growth Factor><Modeling><Modification><Molecular Analysis><Murine><Mus><NCATS><National Center for Advancing Translational Sciences><Non-Polyadenylated RNA><Palsy><Paralysed><Particle Size><Patients><Pharmacokinetics><Phase><Physiopathology><Platelet Transforming Growth Factor><Play><Plegia><Process><Production><Pulmonary Hypertension><Quality Control><RNA><RNA Gene Products><RNA based therapeutics><RNA based therapy><RNA delivery><RNA targeting drug><RNA targeting therapeutics><RNA therapy><RNA-targeting therapy><Reproducibility><Ribonucleic Acid><Role><SARS-CoV-2 vaccine><SARS-coronavirus-2 vaccine><Safety><Severe Acute Respiratory Syndrome CoV 2 vaccine><Severe acute respiratory syndrome coronavirus 2 vaccine><Signal Pathway><Specificity><Standardization><System><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Technology><Therapeutic><Therapeutic Effect><Tissues><Toxic effect><Toxicities><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Treatment Efficacy><Validation><Vascular Diseases><Vascular Disorder><Vascular Endothelium><alpha-Lipoproteins><analytical method><blood disorder><blood vessel disorder><cardiovascular disease therapy><cardiovascular disorder><cardiovascular disorder therapy><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cellular lineage mapping><cellular lineage tracking><clinical development><clinical translation><clinically translatable><cohort><competitively bound><coronavirus disease 2019 vaccine><coronavirus disease-19 vaccine><design><design validation><design verification><designing><developmental><endothelial dysfunction><flow cytophotometry><health care burden><hemodynamics><hepatic body system><hepatic organ system><hypoxia-induced pulmonary hypertension><hypoxic pulmonary hypertension><indexing><innovate><innovation><innovative><intervention efficacy><lipid based nanoparticle><lipid nanoparticle><manufacture><manufacturing process><nCoV vaccine><nCoV-19 vaccine><nCoV19 vaccine><nano particle delivery><nanoparticle delivered><nanoparticle delivery><nanoparticle therapy><novel><paralysis><paralytic><particle><pathophysiology><pulmonary><quantum><response><safety assessment><sex><social role><success><technology platform><technology system><therapeutic RNA><therapeutic efficacy><therapeutic nanoparticles><therapeutic outcome><therapeutic target><therapy efficacy><therapy outcome><uptake><vaccine against 2019-nCov><vaccine against COVID-19><vaccine against SARS-CoV-2><vaccine against SARS-coronavirus-2><vaccine against Severe Acute Respiratory Syndrome CoV 2><vaccine against Severe acute respiratory syndrome coronavirus 2><vaccine candidates against SARS-CoV-2><vaccine for novel coronavirus><vaccines preventing COVID><vaccines to prevent COVID><validation studies><validations><vascular><vascular bed><vascular dysfunction><vasculopathy><zeta potential>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Steve C Danzer

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$441,375
FY 2026

Project Title

Phenotype-Genotype Relationships in Tuberous Sclerosis

Grant Number:

1R21NS141450-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/13/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary Tuberous Sclerosis (TS) is a rare genetic disorder associated with benign tumors and neurological symptoms including autism and epilepsy. TS is caused by mutations in the genes coding for tuberous sclerosis complex proteins 1 and 2 (TSC1/2). Mutations in TSC2 are both more common and produce...

Research Terms

<0-11 years old><ASD><Address><Affect><Alleles><Allelomorphs><Area><Autism><Autistic Disorder><Basic Research><Basic Science><Benign><Biological><Body Tissues><Bourneville Disease><Bourneville Phakomatosis><Bourneville syndrome><Bourneville-Brissaud disease><Bourneville-Pringle syndrome><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cell Signaling><Cell Survival><Cell Viability><Cells><Cellular Expansion><Cellular Function><Cellular Growth><Cellular Morphology><Cellular Physiology><Cellular Process><Child><Child Youth><Children (0-21)><Children's Hospital><Clinic><Clinical><Code><Coding System><Collaborations><Complex><Consultations><DNA mutation><Data><Development><Diagnosis><Diagnostic><Disease><Disorder><Dominant Genetic Conditions><Dominant trait><Early Infantile Autism><Environmental Factor><Environmental Risk Factor><Epilepsy><Epileptic Seizures><Epileptics><Epiloia><Exons><Expression Signature><FDA approved><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Future><Gene Alteration><Gene Expression><Gene Expression Profile><Gene Mutation><Genes><Genetic><Genetic Change><Genetic Diseases><Genetic Dominant><Genetic defect><Genetic mutation><Genotype><Goals><Human><In Vitro><Individual><Infant><Infantile Autism><Inflammation><Intracellular Communication and Signaling><Intractable Epilepsy><Kanner's Syndrome><Knock-out><Knockout><Knowledge><Lead><Lentiviral Vector><Lentivirinae><Lentivirus><Lentivirus Vector><Life><Link><Location><Measures><Mechanistic Target of Rapamycin><Mice><Mice Mammals><Modern Man><Molecular><Morbidity><Morphology><Mosaicism><Murine><Mus><Mutation><NIH><National Institutes of Health><Nature><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurocyte><Neurologic Disorders><Neurologic Manifestations><Neurologic Signs and Symptoms><Neurologic Symptoms><Neurological Disorders><Neurological Manifestations><Neurological Signs and Symptoms><Neurons><Newly Diagnosed><Nucleus><Ontology><Pathway interactions><Patients><Pb element><Pediatric Hospitals><Phenotype><Physiologic><Physiological><Premature Mortality><Pringle disease><Prognosis><Proteins><RAFT1><Rapamune><Rapamycin><Rapid screening><Refractory epilepsy><Research><SDZ RAD><Seizure Disorder><Seizures><Severities><Severity of illness><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Sirolimus><Somatic Mutation><Strategic Planning><Subcellular Process><Symptoms><Syndrome><System><TSC patients><TSC2><TSC2 gene><TSC4><TSC4 Gene><Testing><Tissues><Tuberin><Tuberous Sclerosis><Tuberous sclerosis protein complex><United States National Institutes of Health><Variant><Variation><adenoma sebaceum><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><autosome><biologic><biological signal transduction><burden of disease><burden of illness><cell culture><cell cultures><cell growth><cell morphology><cerebral sclerosis><clinical diagnosis><consultation><developmental><disease burden><disease phenotype><disease severity><drug discovery><drug-resistant epilepsy><effective therapy><effective treatment><environmental risk><epilepsia><epileptogenic><epiploia><everolimus><experiment><experimental research><experimental study><experiments><gene defect><gene expression pattern><gene expression signature><genetic condition><genetic disorder><genome mutation><global gene expression><global transcription profile><heavy metal Pb><heavy metal lead><hereditary multiple system hamartomatosis><in vivo><inhibitor><kids><loss of function><mRNA Expression><mTOR><mammalian target of rapamycin><mosaic diseases><mosaic disorders><mouse model><murine model><mutant><mutant allele><mutation scanning><mutation screening><neonatal period><neural inflammation><neural manifestation><neurinomatosis centralis><neuroinflammation><neuroinflammatory><neurological disease><neuromatosis universalis><neuronal><neuronal growth><neurospongioblastosis diffusa><new approaches><novel><novel approaches><novel strategies><novel strategy><pathway><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><phacomatosis><pre-clinical><preclinical><rare genetic disease><rare genetic disorder><response to therapy><response to treatment><sNuc-Seq><sclerosis tuberosa><screening><screenings><side effect><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><somatic variant><spongioblastosis circumscripta><therapeutic response><therapy response><transcriptional profile><transcriptional signature><transcriptome><transcriptomics><treatment response><treatment responsiveness><tuberose sclerosis><tuberous sclerosis complex><tuberous sclerosis patients><tumor><youngster>
View Full Project Details on NIH Reporter
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Christina Gross

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$441,375
FY 2026

Project Title

Phenotype-Genotype Relationships in Tuberous Sclerosis

Grant Number:

1R21NS141450-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/13/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary Tuberous Sclerosis (TS) is a rare genetic disorder associated with benign tumors and neurological symptoms including autism and epilepsy. TS is caused by mutations in the genes coding for tuberous sclerosis complex proteins 1 and 2 (TSC1/2). Mutations in TSC2 are both more common and produce...

Research Terms

<0-11 years old><ASD><Address><Affect><Alleles><Allelomorphs><Area><Autism><Autistic Disorder><Basic Research><Basic Science><Benign><Biological><Body Tissues><Bourneville Disease><Bourneville Phakomatosis><Bourneville syndrome><Bourneville-Brissaud disease><Bourneville-Pringle syndrome><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cell Signaling><Cell Survival><Cell Viability><Cells><Cellular Expansion><Cellular Function><Cellular Growth><Cellular Morphology><Cellular Physiology><Cellular Process><Child><Child Youth><Children (0-21)><Children's Hospital><Clinic><Clinical><Code><Coding System><Collaborations><Complex><Consultations><DNA mutation><Data><Development><Diagnosis><Diagnostic><Disease><Disorder><Dominant Genetic Conditions><Dominant trait><Early Infantile Autism><Environmental Factor><Environmental Risk Factor><Epilepsy><Epileptic Seizures><Epileptics><Epiloia><Exons><Expression Signature><FDA approved><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Future><Gene Alteration><Gene Expression><Gene Expression Profile><Gene Mutation><Genes><Genetic><Genetic Change><Genetic Diseases><Genetic Dominant><Genetic defect><Genetic mutation><Genotype><Goals><Human><In Vitro><Individual><Infant><Infantile Autism><Inflammation><Intracellular Communication and Signaling><Intractable Epilepsy><Kanner's Syndrome><Knock-out><Knockout><Knowledge><Lead><Lentiviral Vector><Lentivirinae><Lentivirus><Lentivirus Vector><Life><Link><Location><Measures><Mechanistic Target of Rapamycin><Mice><Mice Mammals><Modern Man><Molecular><Morbidity><Morphology><Mosaicism><Murine><Mus><Mutation><NIH><National Institutes of Health><Nature><Nerve Cells><Nerve Unit><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neuranatomies><Neuranatomy><Neuroanatomies><Neuroanatomy><Neurocyte><Neurologic Disorders><Neurologic Manifestations><Neurologic Signs and Symptoms><Neurologic Symptoms><Neurological Disorders><Neurological Manifestations><Neurological Signs and Symptoms><Neurons><Newly Diagnosed><Nucleus><Ontology><Pathway interactions><Patients><Pb element><Pediatric Hospitals><Phenotype><Physiologic><Physiological><Premature Mortality><Pringle disease><Prognosis><Proteins><RAFT1><Rapamune><Rapamycin><Rapid screening><Refractory epilepsy><Research><SDZ RAD><Seizure Disorder><Seizures><Severities><Severity of illness><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single-Nucleus Sequencing><Sirolimus><Somatic Mutation><Strategic Planning><Subcellular Process><Symptoms><Syndrome><System><TSC patients><TSC2><TSC2 gene><TSC4><TSC4 Gene><Testing><Tissues><Tuberin><Tuberous Sclerosis><Tuberous sclerosis protein complex><United States National Institutes of Health><Variant><Variation><adenoma sebaceum><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><autosome><biologic><biological signal transduction><burden of disease><burden of illness><cell culture><cell cultures><cell growth><cell morphology><cerebral sclerosis><clinical diagnosis><consultation><developmental><disease burden><disease phenotype><disease severity><drug discovery><drug-resistant epilepsy><effective therapy><effective treatment><environmental risk><epilepsia><epileptogenic><epiploia><everolimus><experiment><experimental research><experimental study><experiments><gene defect><gene expression pattern><gene expression signature><genetic condition><genetic disorder><genome mutation><global gene expression><global transcription profile><heavy metal Pb><heavy metal lead><hereditary multiple system hamartomatosis><in vivo><inhibitor><kids><loss of function><mRNA Expression><mTOR><mammalian target of rapamycin><mosaic diseases><mosaic disorders><mouse model><murine model><mutant><mutant allele><mutation scanning><mutation screening><neonatal period><neural inflammation><neural manifestation><neurinomatosis centralis><neuroinflammation><neuroinflammatory><neurological disease><neuromatosis universalis><neuronal><neuronal growth><neurospongioblastosis diffusa><new approaches><novel><novel approaches><novel strategies><novel strategy><pathway><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><phacomatosis><pre-clinical><preclinical><rare genetic disease><rare genetic disorder><response to therapy><response to treatment><sNuc-Seq><sclerosis tuberosa><screening><screenings><side effect><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><somatic variant><spongioblastosis circumscripta><therapeutic response><therapy response><transcriptional profile><transcriptional signature><transcriptome><transcriptomics><treatment response><treatment responsiveness><tuberose sclerosis><tuberous sclerosis complex><tuberous sclerosis patients><tumor><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Guillermo Gonzalez-Burgos

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$437,250
FY 2026

Project Title

Parvalbumin neuron diversity and plasticity in primary visual and prefrontal cortical areas

Grant Number:

1R21MH142912-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Parvalbumin interneurons (PVIs) are essential for regulating cortical network activity, playing key roles in both the primary visual cortex (V1) and in the prefrontal cortex (PFC). PVIs have been implicated in schizophrenia, bipolar disorder, autism, and major depression, with transc...

Research Terms

<AD dementia><ASD><Adolescent><Adolescent Youth><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Architecture><Area><Autism><Autistic Disorder><Axon><Behavior><Behavioral><Bipolar Affective Psychosis><Bipolar Disorder><Cell Body><Cells><Classification><Connector Neuron><Data><Development><Disease><Disorder><Dysfunction><Early Infantile Autism><Electrophysiology><Electrophysiology (science)><Engineering / Architecture><Functional disorder><Gene Expression><Gene Transcription><Genes><Genetic Transcription><Goals><Health><House mice><Human><Immediate Memory><Infantile Autism><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Intervention><Investigation><Kanner's Syndrome><Link><Major Depressive Disorder><Manic-Depressive Psychosis><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Messenger RNA><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Morphology><Murine><Mus><Mus musculus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Non-Polyadenylated RNA><Parvalbumins><Pathway interactions><Pattern><Phenotype><Physiologic><Physiological><Physiology><Physiopathology><Pilot Projects><Play><Population><Prefrontal Cortex><Primary Senile Degenerative Dementia><Primary visual cortex><Property><Protocol><Protocols documentation><Psychiatric Disease><Psychiatric Disorder><Psychological Health><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Research><Resolution><Ribonucleic Acid><Role><Schizophrenia><Schizophrenic Disorders><Sensory><Shapes><Short-Term Memory><Social isolation><Striate Cortex><Striate area><Systematics><Techniques><Testing><Transcript><Transcription><Visual><Visual Cortex><area striata><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><bipolar affective disorder><bipolar disease><bipolar illness><bipolar mood disorder><clinical depression><dementia praecox><developmental><electrophysiological><global gene expression><global transcription profile><innovate><innovation><innovative><insight><juvenile><juvenile human><mRNA><major depression><major depression disorder><manic depressive disorder><manic depressive illness><mental illness><multi-modality><multimodality><neuronal><novel><patch clamp><patch sequencing><patch-seq><patchseq><pathophysiology><pathway><pilot study><postnatal><primary degenerative dementia><psychiatric illness><psychological disorder><reconstruction><regional difference><resolutions><response><scRNA sequencing><scRNA-seq><schizophrenic><senile dementia of the Alzheimer type><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><visual cortical><visual stimulus><working memory>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

James Thomas Neal

BROAD INSTITUTE, INC., CAMBRIDGE, MA

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$436,250
FY 2026

Project Title

Rapid drug repurposing for rare disorders by pooled image-based profiling

Grant Number:

1R21TR006289-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Collectively, rare diseases are common, affecting nearly 1 in 10 in the U.S.A. Unfortunately, ~90% lack approved treatments. Traditional drug development is prohibitively slow and costly, especially for rare disorders with small patient populations and lacking screenable phenotypes....

Research Terms

<Acceleration><Address><Affect><American><Bar Codes><Budgets><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cell Body><Cells><Code><Coding System><Collaborations><Communities><Consumption><Costs and Benefits><Data><Data Set><Disease><Disorder><Dose><Drug Industry><Drug Screening><Drugs><Exposure to><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Family><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Foundations><Funding><Future><Genetic Code><Heart Muscle Cells><Heart myocyte><Image><Incentives><Industry><Investigators><Libraries><Medication><Medicine><Methodology><Microscopy><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Optics><Orphan Disease><Pain><Painful><Paint><Pathogenicity><Patients><Performance><Persons><Pharmaceutic Industry><Pharmaceutical Industry><Pharmaceutical Preparations><Phenotype><Physiologic><Physiological><Population><Proteins><Protocol><Protocols documentation><PubChem><Rare Diseases><Rare Disorder><Reagent><Research><Research Personnel><Researchers><Safety><Scientist><Technology><Testing><Therapeutic><Time><Translating><Validation><Variant><Variation><barcode><candidate identification><cardiomyocyte><cell type><compound repositioning><compound repurposing><cost><data access><depository><disease phenotype><drug detection><drug development><drug discovery><drug repositioning><drug repurposing><drug testing><drug/agent><empowerment><high dimensionality><imaging><improved><innovative technologies><internet portal><neuronal><new approaches><new technology><new therapeutic uses for existing drugs><new use of drug><new uses for an approved drug><new uses for existing drugs><novel><novel approaches><novel strategies><novel strategy><novel technologies><off-label><on-line portal><online portal><open source><optical><orphan disorder><parallelization><patient population><pharmacological repurposing><prototype><repositioning approved drugs><repositioning existing drugs><repository><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><response><scale up><screening><screenings><success><therapeutic agent development><therapeutic development><therapeutic repositioning><therapeutic repurposing><user-friendly><validations><web portal><web-based portal>
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BRIAN David FOY

UNIVERSITY OF NEBRASKA MEDICAL CENTER, OMAHA, NE

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$436,157
FY 2026

Project Title

Reassessing West Nile virus action thresholds for improved disease control

Grant Number:

1R21AI197265-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/6/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract West Nile virus (WNV) is the most consequential arthropod-borne virus (arbovirus) in the US, and due to the lack of effective treatments or vaccines, preventing human exposures to infectious mosquitoes is key to controlling transmission. Mosquito-based surveillance for WNV i...

Research Terms

<Address><Affect><Arboviral><Arboviruses><Area><Arthropod-Borne Viruses><Assay><Aves><Avian><Behavior><Bioassay><Biologic Factor><Biological><Biological Assay><Biological Factors><Biology><Biometrics><Biometry><Biostatistics><Birds><Blood><Blood Reticuloendothelial System><Body Tissues><C pipiens><C. pipiens><Colorado><Culex pipiens><Culex pipiens mosquito><Culicidae><Cx pipiens><Cx. pipiens><Data><Data Set><Decision Making><Detection><Dose><Egypt 101 virus><Experimental Designs><Exposure to><Foundations><Future><Generalized Growth><Goals><Growth><Human><Incubated><Individual><Infection><Insecticides><Investigation><Kinetics><Knowledge><Laboratories><Measures><Methodology><Modeling><Modern Man><Mosquito-borne disease><Mosquito-borne infectious disease><Mosquitoes><Nebraska><Output><Policy Maker><Public Health><Risk><Risk Estimate><Saliva><Source><Surveillance Program><Testing><Time><Tissue Growth><Tissues><Transmission><United States><Vaccines><Variant><Variation><Viremia><Virus><WNV><West Nile viral infection><West Nile virus><West Nile virus infection><Work><arthropod transmission><arthropod transmitted><arthropod-borne><arthropodborne><biologic><blood meal><cost><disease control><disorder control><effective therapy><effective treatment><epidemiological model><experiment><experimental research><experimental study><experiments><exposed human population><human exposure><improved><indexing><infected with West Nile virus><infection risk><infection with West Nile virus><innovate><innovation><innovative><lab assignment><lab experiment><laboratory activity><laboratory assignment><laboratory exercise><laboratory experiment><ontogeny><preservation><prevent><preventing><public health intervention><public trust><social><spatial and temporal><spatial temporal><spatiotemporal><surveillance data><transmission process><vector><viraemia><viral RNA><viral sepsis><viral transmission><virus RNA><virus transmission><virusemia>
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Joseph Robert Fauver

UNIVERSITY OF NEBRASKA MEDICAL CENTER, OMAHA, NE

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$436,157
FY 2026

Project Title

Reassessing West Nile virus action thresholds for improved disease control

Grant Number:

1R21AI197265-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/6/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract West Nile virus (WNV) is the most consequential arthropod-borne virus (arbovirus) in the US, and due to the lack of effective treatments or vaccines, preventing human exposures to infectious mosquitoes is key to controlling transmission. Mosquito-based surveillance for WNV i...

Research Terms

<Address><Affect><Arboviral><Arboviruses><Area><Arthropod-Borne Viruses><Assay><Aves><Avian><Behavior><Bioassay><Biologic Factor><Biological><Biological Assay><Biological Factors><Biology><Biometrics><Biometry><Biostatistics><Birds><Blood><Blood Reticuloendothelial System><Body Tissues><C pipiens><C. pipiens><Colorado><Culex pipiens><Culex pipiens mosquito><Culicidae><Cx pipiens><Cx. pipiens><Data><Data Set><Decision Making><Detection><Dose><Egypt 101 virus><Experimental Designs><Exposure to><Foundations><Future><Generalized Growth><Goals><Growth><Human><Incubated><Individual><Infection><Insecticides><Investigation><Kinetics><Knowledge><Laboratories><Measures><Methodology><Modeling><Modern Man><Mosquito-borne disease><Mosquito-borne infectious disease><Mosquitoes><Nebraska><Output><Policy Maker><Public Health><Risk><Risk Estimate><Saliva><Source><Surveillance Program><Testing><Time><Tissue Growth><Tissues><Transmission><United States><Vaccines><Variant><Variation><Viremia><Virus><WNV><West Nile viral infection><West Nile virus><West Nile virus infection><Work><arthropod transmission><arthropod transmitted><arthropod-borne><arthropodborne><biologic><blood meal><cost><disease control><disorder control><effective therapy><effective treatment><epidemiological model><experiment><experimental research><experimental study><experiments><exposed human population><human exposure><improved><indexing><infected with West Nile virus><infection risk><infection with West Nile virus><innovate><innovation><innovative><lab assignment><lab experiment><laboratory activity><laboratory assignment><laboratory exercise><laboratory experiment><ontogeny><preservation><prevent><preventing><public health intervention><public trust><social><spatial and temporal><spatial temporal><spatiotemporal><surveillance data><transmission process><vector><viraemia><viral RNA><viral sepsis><viral transmission><virus RNA><virus transmission><virusemia>
View Full Project Details on NIH Reporter
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Joe Nassour

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$429,000
FY 2026

Project Title

Lysosome-Golgi Contact Sites as Regulators of Senescence-Associated Inflammation

Grant Number:

1R21AG100775-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY / ABSTRACT Chronic, low-grade inflammation is a hallmark of aging and a key driver of multiple age-related diseases. Accumulated senescent cells in aged tissues contribute to local and systemic inflammation by releasing a range of pro-inflammatory factors, collectively termed the sen...

Research Terms

<Acceleration><Adopted><Adult Progeria><Aging><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Architecture><Atlases><Autoregulation><Biology><Body Tissues><CRISPR><CRISPR editing screen><CRISPR screen><CRISPR-based screen><CRISPR/Cas system><CRISPR/Cas9 screen><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Signaling><Cells><Cellular Proliferation><Chemotactic Cytokines><Chronic><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats><Complex><Data><Destinations><Development><Disease Progression><Dose Limiting><Drugs><Endosomes><Engineering / Architecture><Epithelial Cells><Esteroproteases><Exploratory/Developmental Grant><FLJ11330><Fibroblasts><Foundations><Future><Gene Expression><Gene Transcription><Genes><Genetic Transcription><Genomic DNA><Golgi><Golgi Apparatus><Golgi Complex><Homeostasis><Homologous Chemotactic Cytokines><Human><Hutchinson-Gilford Disease><Hutchinson-Gilford Syndrome><Immune><Immune Cell Activation><Immune signaling><Immunes><Individual><Inflammaging><Inflammation><Inflammatory><Intercrines><Interruption><Intervention><Intracellular Communication and Signaling><Kinases><Label><Light><Link><Lysosomes><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Medication><Membrane><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Mission><Mitochondrial DNA><Modeling><Modern Man><Molecular><NF-Kb-Activating Kinase Gene><Onset of illness><Organelles><Output><Pathologic><Pathway interactions><Peptidases><Peptide Hydrolases><Pharmaceutical Preparations><Phosphotransferase Gene><Phosphotransferases><Photoradiation><Physiologic><Physiological><Physiological Homeostasis><Position><Positioning Attribute><Premature Senility Syndrome><Process><Progeria><Protease Gene><Proteases><Proteinases><Proteins><Proteolytic Enzymes><Proteomics><R-Series Research Projects><R01 Mechanism><R01 Program><R21 Mechanism><R21 Program><RNA Expression><Receptosomes><Regulation><Research><Research Grants><Research Project Grants><Research Projects><Resolution><Role><Route><SIS cytokines><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Site><Surface Proteins><System><T2K><TBK1><TBK1 gene><Testing><Tissues><Toxic effect><Toxicities><Transcription><Transphosphorylases><Werner Syndrome><Werner's syndrome><Work><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age specific><age-related disease><age-related disorder><age-related impairment><age-related inflammation><aged><aging associated inflammation><ameliorating inflammaging><anti-inflammaging><attenuate inflammaging><attenuation of senescence><biological signal transduction><cell age><cellular age><chemoattractant cytokine><chemokine><clustered regularly interspaced short palindromic repeats screen><cohort><combat><cytokine><decrease senescence><delay senescence><design><designing><developmental><disease onset><disorder onset><drug/agent><exploratory developmental study><gDNA><genome scale><genome-wide><genomewide><hallmarks of aging><healthy aging><healthy human aging><high reward><high risk><immune activation><in vitro Model><inflamm-ageing><inflamm-aging><inflammaging mitigation><inflammation associated with aging><insight><interest><membrane structure><mitigate age related inflammation><mtDNA><next generation><novel><oncogene induced senescence><oncogenic senescence><pathway><pharmacologic><pillars of aging><prevent><prevent age related inflammation><prevent inflammaging><preventing><programs><recruit><reduce senescence><reducing age related inflammation><reducing cellular senescence><repress senescence><resolutions><scaffold><scaffolding><senescence><senescence and its associated secretory phenotype><senescence associated secretome><senescence associated secretory factors><senescence associated secretory pathway><senescence associated secretory phenotype><senescence associated secretory program><senescence associated secretory proteins><senescence mitigation><senescent><senescent associated secretome><senescent associated secretory phenotype><senescent cell><senolytics><senomorphic><senostatic><social role><spectral image><spectral imagery><spectrograph><spectrum image><spectrum imagery><suppress senescence><systemic inflammation><systemic inflammatory response><therapeutic target><trafficking>
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Jeffrey Robert Millman

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$427,625
FY 2026

Project Title

A Modular Biomanufacturing and Cryopreservation Platform for Scalable Production of Clinical-Grade Stem Cell Therapies

Grant Number:

1R21TR006271-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Human induced pluripotent stem cells (hiPSCs) are a foundational technology for regenerative medicine, disease modeling, and cell-based therapies. However, the clinical translation of hiPSC-derived therapeutics is constrained by unresolved challenges in manufacturing scalability, product consistency...

Research Terms

<Acceleration><Address><Autoregulation><Benchmarking><Best Practice Analysis><Biomanufacturing><Bioreactors><Brittle Diabetes Mellitus><Cell Body><Cell Components><Cell Line><Cell Structure><Cell Survival><Cell Therapy><Cell Viability><Cell-Extracellular Matrix><CellLine><Cells><Cellular Structures><Clinic><Clinical><Complex><Cost efficiency><Coupled><Cryofixation><Cryopreservation><Differentation Markers><Differentiation Antigens><Differentiation Markers><Disease><Disorder><Dissociation><ECM><Endocrine><Engineering><Epithelium><Exploratory/Developmental Grant><Extracellular Matrix><Feeds><Foundations><Freezing><Future><Generalized Growth><Genetic><Genome Instability><Genome Stability><Genomic Instability><Genomic Stability><Goals><Good Manufacturing Process><Good manufacturing practice><Growth><Harvest><Homeostasis><Human><IDDM><Immune><Immune mediated therapy><Immunes><Immunologically Directed Therapy><Immunotherapy><In Vitro><Insulin-Dependent Diabetes Mellitus><Juvenile-Onset Diabetes Mellitus><Karyotype><Ketosis-Prone Diabetes Mellitus><Logistics><Manuals><Marker Antigens><Methods><Modern Man><Morphology><NIH><National Institutes of Health><O element><O2 element><Outcome><Output><Oxygen><Paralysis Agitans><Parkinson><Parkinson Disease><Performance><Perfusion><Phenotype><Physiological Homeostasis><Play><Position><Positioning Attribute><Preparedness><Primary Parkinsonism><Production><Protocol><Protocols documentation><R21 Mechanism><R21 Program><Readiness><Reagent><Regenerative Medicine><Regenerative engineering><Reproducibility><Running><SNP array><SNP chip><Single Base Polymorphism><Single Nucleotide Polymorphism><Standardization><Stem Cell like><Strains Cell Lines><Sudden-Onset Diabetes Mellitus><Suspension substance><Suspensions><System><T1 DM><T1 diabetes><T1D><T1DM><Technology><Testing><Therapeutic><Time><Tissue Growth><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><United States National Institutes of Health><Work><benchmark><cell based intervention><cell engineering><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular engineering><cellular therapeutic><cellular therapy><clinical relevance><clinical translation><clinically relevant><clinically translatable><cold preservation><cold storage><cost><cultured cell line><density><design><designing><differentiation protocol><disease model><disorder model><engineered immune system><exploratory developmental study><flasks><flexibility><flexible><full scale manufacturing><genome integrity><genomic integrity><hiPSC><high reward><high risk><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><immune engineering><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunoengineering><improved><induced human pluripotent stem cells><industrial partnership><industry partner><industry partnership><innovate><innovation><innovative><insulin dependent diabetes><insulin dependent type 1><juvenile diabetes><juvenile diabetes mellitus><karyogram><ketosis prone diabetes><large scale manufacturing><large scale production><manufacture><manufacturing systems><mass production><microbioreactor><ontogeny><pluripotency><pluripotent state><preservation><progenitor capacity><progenitor cell based therapy><progenitor cell delivery><progenitor cell differentiation><progenitor cell expansion><progenitor cell like><progenitor cell therapy><progenitor cell treatment><progenitor delivery><progenitor differentiation><progenitor expansion><progenitor therapy><progenitor treatment><progenitor-like><prototype><scale up><single nucleotide polymorphism array><single nucleotide polymorphism chip><single nucleotide variant><stem and progenitor cell expansion><stem and progenitor cell therapy><stem and progenitor differentiation><stem cell based therapy><stem cell characteristics><stem cell delivery><stem cell differentiation><stem cell expansion><stem cell mediated therapy><stem cell therapeutics><stem cell therapy><stem cell treatment><stem cell-based therapeutic><stem cell-based treatment><stem-like><stemness><success><surface coating><therapeutic agent development><therapeutic development><translational pipeline><translational spectrum><type I diabetes><type one diabetes>
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Roland M Tisch

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$427,625
FY 2026

Project Title

Coreceptor therapy-induced de-differentiation of autoreactive Tfh

Grant Number:

1R21AI197041-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

SUMMARY/ABSTRACT Type 1 diabetes (T1D) is characterized by the T cell-mediated destruction of the insulin producing b cells in the islets of Langerhans. Currently, there is no cure for T1D, highlighting the ongoing need for immunotherapies that effectively suppress b cell autoimmunity long-term for ...

Research Terms

<Ablation><Antibodies><Antibody Therapy><Antigens><Autoantigens><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Autologous Antigens><Automobile Driving><B blood cells><B cell><B cell lymphoma 6><B cells><B-Cell CLL/Lymphoma-6 Gene><B-Cells><B-Lymphocytes><B-cell><B9 endocrine pancreas><BCL5><BCL6><BCL6 gene><Basal Transcription Factor><Basal transcription factor genes><Binding><Brittle Diabetes Mellitus><CD8><CD8B><CD8B1><CD8B1 gene><CSIF><CSIF-10><CTL A4-Ig B7 Inhibitor><CTLA-4-Ig><CTLA4-Fc><CTLA4-Ig><CTLA4-Ig immunoconjugate><Causality><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cys-His2 Zinc Finger Transcription Factor Gene><Cytokine Synthesis Inhibitory Factor><Data><Diabetes Mellitus><Dose><Endocrine Pancreas><Equilibrium><Eragrostis><Etiology><Exhibits><FKHR><FOXO1><FOXO1A><FOXO1A gene><Forkhead Box O1A><Forkhead in Rhabdomyosarcoma><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic><Genetic Transcription><Goals><Graft Rejection><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Human><Humulin R><IDDM><IL-10><IL10><IL10A><IL21><Immune mediated therapy><Immunologically Directed Therapy><Immunomodulation><Immunotherapy><Impairment><Inbred NOD Mice><Inducer Cells><Inducer T-Lymphocytes><Insulin><Insulin-Dependent Diabetes Mellitus><Interleukin 10 Precursor><Interleukin-10><Intracellular Communication and Signaling><Islands of Langerhans><Islets of Langerhans><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><LAZ-3 Gene><LAZ3><LYT3><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Molecular Interaction><Murine><Mus><NOD Mouse><Nesidioblasts><Non-Obese Diabetic Mice><Nonobese Diabetic Mouse><Novolin R><PI-3K/AKT><PI3K/AKT><Pancreatic Islets><Pars endocrina pancreatis><Pathogenicity><Pathology><Patients><Peptides><Phenotype><Preventative strategy><Prevention strategy><Preventive strategy><Process><Property><RNA Expression><Receptor Protein><Regular Insulin><Regulatory T-Lymphocyte><Repression><Self Tolerance><Self-Antigens><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><Sudden-Onset Diabetes Mellitus><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T1 DM><T1 diabetes><T1D><T1DM><Teff><Teff cell><Testing><Therapeutic Intervention><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transplant Rejection><Transplantation Rejection><Treatment Efficacy><Treg><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Upregulation><Work><ZNF51><ZNF51 Gene><Zinc Finger Protein 51 Gene><antibody based therapies><antibody treatment><antibody-based therapeutics><antibody-based treatment><autoimmune condition><autoimmune disorder><autoimmune reactivity><autoimmunity disease><autoreactivity><balance><balance function><biological signal transduction><causation><cell dedifferentiation><combinatorial><cytotoxic T lymphocyte-associated antigen 4-immunoglobulin><determine efficacy><diabetes><diabetogenic><disease causation><disease prevention><disorder prevention><driving><effector T cell><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><fitness><humanized mice><humanized mouse><immune modulation><immune regulation><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><in vivo><innovate><innovation><innovative><insulin dependent diabetes><insulin dependent type 1><interleukin-21><intervention efficacy><intervention therapy><islet><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><new approaches><non-obese diabetic (NOD) mice><nonobese diabetic (NOD) mice><novel approaches><novel strategies><novel strategy><pre-clinical><preclinical><prevent><preventing><receptor><regulatory T-cells><response><synergism><therapeutic efficacy><therapy efficacy><thymus derived lymphocyte><transcription factor><translational opportunities><translational potential><type I diabetes><type one diabetes>
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JIA-WEN GUO

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$423,500
FY 2026

Project Title

Decision-Making Capacity Assessment and Inclusive Decision-Making for Older Persons with Capacity Challenges

Grant Number:

1R21AG098947-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

An estimated 6.9 million Americans are currently living with Alzheimer’s dementia, a number expected to reach 12.7 million by 2050. People with dementia, along with others who have decisional limitations, face threats to their legal and autonomy rights to manage health care, residential, and other p...

Research Terms

<AD dementia><Address><Affect><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Ambulatory Care><Amentia><American><Apoplexy><Area><Assessment instrument><Assessment tool><Attitude><Authorization><Authorization documentation><Brain Vascular Accident><Caring><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Characteristics><Classification><Clinical><Data><Decision Making><Dementia><Development><Discipline><Discipline of Nursing><Due Process><Economic Income><Economical Income><Education><Educational aspects><Effectiveness><Ethics><Exclusion><Face><Future><Generations><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><Grant><Health><Health Care><Hospitals><Impairment><Income><Individual><Informed Consent><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Intervention Studies><Interview><Judgment><Laws><Legal><Life><Literature><Low income><Measures><Medical><Nursing><Nursing Field><Nursing Homes><Nursing Profession><Older Population><Outpatient Care><Perception><Performance><Permission><Personal Satisfaction><Persons><Policies><Population><Primary Senile Degenerative Dementia><Process><Proxy><Psychiatrist><Psychology><Qualitative Methods><Recommendation><Research><Rights><Risk><Rural><Side><Social Service><Social Work><Specialty><Stroke><Structure><Survey Instrument><Surveys><Systematics><Testing><Time><Training><Validity and Reliability><Work><abuse liability><abuse potential><ages><brain attack><cerebral vascular accident><cerebrovascular accident><clinical care><clinical practice><cognitive interview><decision-making capacity><developmental><ethical><experience><faces><facial><geographic site><health care management><health management><impaired capacity><improved><incomes><insight><intellectual and developmental disability><intervention research><interventional research><interventional study><interventions research><limited intellectual functioning><medical college><medical schools><medical specialties><nursing home><older groups><older individuals><older person><outpatient treatment><patient population><pilot test><primary degenerative dementia><programs><qualitative reasoning><response><school of medicine><senile dementia of the Alzheimer type><stroked><strokes><surrogate decision maker><surrogate decision making><well-being><wellbeing><willingness>
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Maureen Henry

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$423,500
FY 2026

Project Title

Decision-Making Capacity Assessment and Inclusive Decision-Making for Older Persons with Capacity Challenges

Grant Number:

1R21AG098947-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

An estimated 6.9 million Americans are currently living with Alzheimer’s dementia, a number expected to reach 12.7 million by 2050. People with dementia, along with others who have decisional limitations, face threats to their legal and autonomy rights to manage health care, residential, and other p...

Research Terms

<AD dementia><Address><Affect><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Ambulatory Care><Amentia><American><Apoplexy><Area><Assessment instrument><Assessment tool><Attitude><Authorization><Authorization documentation><Brain Vascular Accident><Caring><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Characteristics><Classification><Clinical><Data><Decision Making><Dementia><Development><Discipline><Discipline of Nursing><Due Process><Economic Income><Economical Income><Education><Educational aspects><Effectiveness><Ethics><Exclusion><Face><Future><Generations><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><Grant><Health><Health Care><Hospitals><Impairment><Income><Individual><Informed Consent><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention><Intervention Studies><Interview><Judgment><Laws><Legal><Life><Literature><Low income><Measures><Medical><Nursing><Nursing Field><Nursing Homes><Nursing Profession><Older Population><Outpatient Care><Perception><Performance><Permission><Personal Satisfaction><Persons><Policies><Population><Primary Senile Degenerative Dementia><Process><Proxy><Psychiatrist><Psychology><Qualitative Methods><Recommendation><Research><Rights><Risk><Rural><Side><Social Service><Social Work><Specialty><Stroke><Structure><Survey Instrument><Surveys><Systematics><Testing><Time><Training><Validity and Reliability><Work><abuse liability><abuse potential><ages><brain attack><cerebral vascular accident><cerebrovascular accident><clinical care><clinical practice><cognitive interview><decision-making capacity><developmental><ethical><experience><faces><facial><geographic site><health care management><health management><impaired capacity><improved><incomes><insight><intellectual and developmental disability><intervention research><interventional research><interventional study><interventions research><limited intellectual functioning><medical college><medical schools><medical specialties><nursing home><older groups><older individuals><older person><outpatient treatment><patient population><pilot test><primary degenerative dementia><programs><qualitative reasoning><response><school of medicine><senile dementia of the Alzheimer type><stroked><strokes><surrogate decision maker><surrogate decision making><well-being><wellbeing><willingness>
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John Schneider

UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$417,567
FY 2026

Project Title

A Sicangu-driven social network strategy for syphilis prevention

Grant Number:

1R21AI191042-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/9/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract This developmental research grant award (R21) requests funds to characterize the social and transmission networks of Rosebud Sioux Tribe (RST) (Sicangu Lakota Oyate) community members to mitigate ongoing and future syphilis epidemics among American Indian/Alaska Native (AI/AN) populations a...

Research Terms

<Access to Care><Acquaintances><Address><Age><Alaska Indian><Alaska Native><Alaska Native group><Alaska Native individual><Alaska Native people><Alaska Native population><Alaska Natives><Alaskan American><Alaskan Indian><Alaskan Native><Alaskan Native American><Alaskan Natives><American Indian><American Indian Population><American Indian group><American Indian individual><American Indian people><American Indians><Award><Awareness><Behavior><Biological><Cheyenne><Chronic><Clinic><Communicable Disease Contact Tracing><Communities><Computer Models><Computerized Models><Congenital Syphilis><Contact Tracing><Country><Data><Detection><Development><Diffuse><Diffusion><Discipline of obstetrics><Disease Outbreaks><Drug Therapy><Education><Educational aspects><Emergencies><Emergency Situation><Employment><Epidemic><Epidemiology><Exclusion><Family><Federal Government><Funding><Future><Gestation><Government><Great Plains><Health><Health Care Providers><Health Personnel><Health Services Accessibility><Hospitals><Indian Health Service><Individual><Infectious Disease Contact Tracing><Intervention><Job Location><Job Place><Job Setting><Job Site><Lakota><Lakota Sioux><Language><Measures><Medicaid><Modeling><Names><National Government><Network Analysis><Obstetrics><Outbreaks><Participant><Pathway Analysis><Persons><Pharmacological Treatment><Pharmacotherapy><Policies><Pregnancy><Pregnant Women><Prenatal care><Preventative intervention><Prevention><Privacy><Protocol><Protocols documentation><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Reporting><Research Grants><Research Project Grants><Research Projects><Research Resources><Reservations><Resources><Risk><Rural Community><Sampling><Sexual Health><Sioux><Sioux Indians><Site><Social Network><Social support><South Dakota><Stigmatization><Stream><Structure><Subgroup><Survey Instrument><Surveys><Syphilis><System><Testing><Teton Sioux><Teton Sioux Indian><Tracer><Transmission><Trauma><Tribes><Uncertainty><United States Indian Health Service><Violence><Work><Work Location><Work Place><Work-Site><Workplace><Worksite><access to health care><access to health services><access to services><access to treatment><accessibility of health care><accessibility to health care><accessibility to health services><ages><availability of services><biologic><care access><clinical care><communicable disease transmission><computational modeling><computational models><computer based models><computerized modeling><condoms><density><developmental><diffused><diffuses><diffusing><diffusions><disease transmission><doubt><drug intervention><drug treatment><epidemic concern><epidemic potential><epidemic risk><epidemic threat><epidemiologic><epidemiological><expectant mother><expectant women><expecting mother><expecting women><experience><future epidemic><great pox><health care access><health care availability><health care personnel><health care service access><health care service availability><health care worker><health provider><health service access><health services availability><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><improved><indigenous community><individuals who are pregnant><infectious disease transmission><innovate><innovation><innovative><intervention for prevention><marginalization><marginalized group><marginalized individual><marginalized people><marginalized population><medical care providers><medical personnel><member><name><named><naming><next epidemic><people who are pregnant><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pregnancy care><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal appointment><prenatal checkup><prenatal visit><prevention intervention><preventional intervention strategy><preventive intervention><programs><public health emergency><public health intervention><recruit><rural area><rural location><rural region><seropositive><service availability><sex><sioux community><social><social interventions><social stigma><social support network><stigma><substance use><substance user><substance using><those who are pregnant><transmission process><treatment access><treatment provider><tribal community><tribal health><uptake><violent><violent behavior><women who are pregnant><work setting>
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CATHERINE A HILL

PURDUE UNIVERSITY, WEST LAFAYETTE, IN

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$415,584
FY 2026

Project Title

AI-powered multimodal precision sensing system to track tick phenotypic responses in natural and simulated environments

Grant Number:

1R21AI188198-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The long-term goal of our team (Drs. Hill, Murgia and Kaur) is to revolutionize control of vector-borne diseases through innovations in autonomous, AI-driven robotics systems for precision pest management. On this two-year R21, we propose the development of a transformative autonomous robotic system...

Research Terms

<21+ years old><AI Augmented><AI algorithm><AI assisted><AI based><AI driven><AI enhanced><AI integrated><AI powered><Abscission><Adoption><Adult><Adult Human><Algorithms><Area><Artificial Intelligence enhanced><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Behavior><Biology><Black-legged Tick><Classification><Complex><Computer software><Data><Data Set><Deer Tick><Dehydration><Detection><Development><Disease Management><Disease Surveillance><Disorder Management><EHF Waves><Ecological impact><Economic Burden><Effectiveness><Engineering><Ensure><Environment><Environmental Exposure><Environmental Impact><Excision><Exposure to><Extirpation><Extremely High Frequency Radio Waves><Foundations><Funding><Future><Goals><Gramineae><Grasses><Habitats><Health><Health Care><Health Care Costs><Health Costs><Human><Human Resources><I scapularis><I. scapularis><Incidence><Individual><Insecticides><Ix scalpularis><Ix. scapularis><Ixodes dammini><Ixodes scapularis><Ixodida><Label><Laboratories><Legal patent><Lyme Borreliosis><Lyme Disease><Manpower><Methodology><Methods><Midwest><Midwest U.S.><Midwest US><Midwestern United States><Modern Man><Morbidity><Movement><NIH><National Institutes of Health><National Security><Nymph><Patents><Performance><Pest Control><Pesticides><Phenotype><Plant Leaves><Poaceae><Population><Population Surveillance><Position><Positioning Attribute><Public Health><Public Health Surveillance><Removal><Research Design><Robot><Robotics><Sampling><Scanning><Security><Software><Source><Study Type><Surgical Removal><System><Systematics><Technology><Testing><Tick Control><Tick Infestations><Tick-Borne Diseases><Ticks><Time><Training><Transmission><United States><United States National Institutes of Health><Vector-borne disease><Vector-borne infectious disease><Vector-transmitted disease><Vector-transmitted infectious disease><Work><acaricide><adulthood><algorithm development><artificial intelligence algorithm><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence based><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><blacklegged tick><body movement><body water dehydration><burden of disease><burden of illness><communicable disease transmission><continuous monitoring><controlling ticks><cost><detection platform><detection system><developmental><disease burden><disease control><disease prevention><disease risk><disease transmission><disorder control><disorder prevention><disorder risk><energy efficiency><enhanced with AI><enhanced with Artificial Intelligence><exposed human population><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><field based data><field learning><field study><field test><forest><health communication><high risk><human exposure><infectious disease transmission><infested with ticks><innovate><innovation><innovative><leaf><millimeter Wave><mm Wave><mmWave><mortality><multi-modality><multimodality><neural network><new technology><novel><novel technologies><personnel><product development><resection><response><robotic system><screening><screenings><sensor><study design><surveillance strategy><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tick bite><tick infested><tick population><tick-borne illness><tickborne disease><tickborne illness><transmission process><vector control><vector-borne illness><vectorborne disease><vectorborne illness><vectorborne infectious disease>
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UPINDER KAUR

PURDUE UNIVERSITY, WEST LAFAYETTE, IN

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$415,584
FY 2026

Project Title

AI-powered multimodal precision sensing system to track tick phenotypic responses in natural and simulated environments

Grant Number:

1R21AI188198-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The long-term goal of our team (Drs. Hill, Murgia and Kaur) is to revolutionize control of vector-borne diseases through innovations in autonomous, AI-driven robotics systems for precision pest management. On this two-year R21, we propose the development of a transformative autonomous robotic system...

Research Terms

<21+ years old><AI Augmented><AI algorithm><AI assisted><AI based><AI driven><AI enhanced><AI integrated><AI powered><Abscission><Adoption><Adult><Adult Human><Algorithms><Area><Artificial Intelligence enhanced><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Behavior><Biology><Black-legged Tick><Classification><Complex><Computer software><Data><Data Set><Deer Tick><Dehydration><Detection><Development><Disease Management><Disease Surveillance><Disorder Management><EHF Waves><Ecological impact><Economic Burden><Effectiveness><Engineering><Ensure><Environment><Environmental Exposure><Environmental Impact><Excision><Exposure to><Extirpation><Extremely High Frequency Radio Waves><Foundations><Funding><Future><Goals><Gramineae><Grasses><Habitats><Health><Health Care><Health Care Costs><Health Costs><Human><Human Resources><I scapularis><I. scapularis><Incidence><Individual><Insecticides><Ix scalpularis><Ix. scapularis><Ixodes dammini><Ixodes scapularis><Ixodida><Label><Laboratories><Legal patent><Lyme Borreliosis><Lyme Disease><Manpower><Methodology><Methods><Midwest><Midwest U.S.><Midwest US><Midwestern United States><Modern Man><Morbidity><Movement><NIH><National Institutes of Health><National Security><Nymph><Patents><Performance><Pest Control><Pesticides><Phenotype><Plant Leaves><Poaceae><Population><Population Surveillance><Position><Positioning Attribute><Public Health><Public Health Surveillance><Removal><Research Design><Robot><Robotics><Sampling><Scanning><Security><Software><Source><Study Type><Surgical Removal><System><Systematics><Technology><Testing><Tick Control><Tick Infestations><Tick-Borne Diseases><Ticks><Time><Training><Transmission><United States><United States National Institutes of Health><Vector-borne disease><Vector-borne infectious disease><Vector-transmitted disease><Vector-transmitted infectious disease><Work><acaricide><adulthood><algorithm development><artificial intelligence algorithm><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence based><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><blacklegged tick><body movement><body water dehydration><burden of disease><burden of illness><communicable disease transmission><continuous monitoring><controlling ticks><cost><detection platform><detection system><developmental><disease burden><disease control><disease prevention><disease risk><disease transmission><disorder control><disorder prevention><disorder risk><energy efficiency><enhanced with AI><enhanced with Artificial Intelligence><exposed human population><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><field based data><field learning><field study><field test><forest><health communication><high risk><human exposure><infectious disease transmission><infested with ticks><innovate><innovation><innovative><leaf><millimeter Wave><mm Wave><mmWave><mortality><multi-modality><multimodality><neural network><new technology><novel><novel technologies><personnel><product development><resection><response><robotic system><screening><screenings><sensor><study design><surveillance strategy><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tick bite><tick infested><tick population><tick-borne illness><tickborne disease><tickborne illness><transmission process><vector control><vector-borne illness><vectorborne disease><vectorborne illness><vectorborne infectious disease>
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Maria Vittoria Murgia

PURDUE UNIVERSITY, WEST LAFAYETTE, IN

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$415,584
FY 2026

Project Title

AI-powered multimodal precision sensing system to track tick phenotypic responses in natural and simulated environments

Grant Number:

1R21AI188198-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

The long-term goal of our team (Drs. Hill, Murgia and Kaur) is to revolutionize control of vector-borne diseases through innovations in autonomous, AI-driven robotics systems for precision pest management. On this two-year R21, we propose the development of a transformative autonomous robotic system...

Research Terms

<21+ years old><AI Augmented><AI algorithm><AI assisted><AI based><AI driven><AI enhanced><AI integrated><AI powered><Abscission><Adoption><Adult><Adult Human><Algorithms><Area><Artificial Intelligence enhanced><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Behavior><Biology><Black-legged Tick><Classification><Complex><Computer software><Data><Data Set><Deer Tick><Dehydration><Detection><Development><Disease Management><Disease Surveillance><Disorder Management><EHF Waves><Ecological impact><Economic Burden><Effectiveness><Engineering><Ensure><Environment><Environmental Exposure><Environmental Impact><Excision><Exposure to><Extirpation><Extremely High Frequency Radio Waves><Foundations><Funding><Future><Goals><Gramineae><Grasses><Habitats><Health><Health Care><Health Care Costs><Health Costs><Human><Human Resources><I scapularis><I. scapularis><Incidence><Individual><Insecticides><Ix scalpularis><Ix. scapularis><Ixodes dammini><Ixodes scapularis><Ixodida><Label><Laboratories><Legal patent><Lyme Borreliosis><Lyme Disease><Manpower><Methodology><Methods><Midwest><Midwest U.S.><Midwest US><Midwestern United States><Modern Man><Morbidity><Movement><NIH><National Institutes of Health><National Security><Nymph><Patents><Performance><Pest Control><Pesticides><Phenotype><Plant Leaves><Poaceae><Population><Population Surveillance><Position><Positioning Attribute><Public Health><Public Health Surveillance><Removal><Research Design><Robot><Robotics><Sampling><Scanning><Security><Software><Source><Study Type><Surgical Removal><System><Systematics><Technology><Testing><Tick Control><Tick Infestations><Tick-Borne Diseases><Ticks><Time><Training><Transmission><United States><United States National Institutes of Health><Vector-borne disease><Vector-borne infectious disease><Vector-transmitted disease><Vector-transmitted infectious disease><Work><acaricide><adulthood><algorithm development><artificial intelligence algorithm><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence based><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><blacklegged tick><body movement><body water dehydration><burden of disease><burden of illness><communicable disease transmission><continuous monitoring><controlling ticks><cost><detection platform><detection system><developmental><disease burden><disease control><disease prevention><disease risk><disease transmission><disorder control><disorder prevention><disorder risk><energy efficiency><enhanced with AI><enhanced with Artificial Intelligence><exposed human population><exposure to environmental agents><exposure to environmental factors><exposure to environmental stimuli><exposure to environmental substances><field based data><field learning><field study><field test><forest><health communication><high risk><human exposure><infectious disease transmission><infested with ticks><innovate><innovation><innovative><leaf><millimeter Wave><mm Wave><mmWave><mortality><multi-modality><multimodality><neural network><new technology><novel><novel technologies><personnel><product development><resection><response><robotic system><screening><screenings><sensor><study design><surveillance strategy><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tick bite><tick infested><tick population><tick-borne illness><tickborne disease><tickborne illness><transmission process><vector control><vector-borne illness><vectorborne disease><vectorborne illness><vectorborne infectious disease>
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Ryan Joseph Weiss

UNIVERSITY OF GEORGIA, ATHENS, GA

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$415,250
FY 2026

Project Title

Repurposing the PI3Kα inhibitor Alpelisib for the treatment of Multiple Hereditary Exostoses

Grant Number:

1R21TR005505-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Multiple hereditary exostoses (MHE) is an autosomal dominant disorder that affects one in every 50,000 children worldwide and is characterized by the formation of cartilage-capped osteochondromas, known as exostoses, adjacent to the growth plates of long bones and other skeletal elements. Due to the...

Research Terms

<0-11 years old><1-Phosphatidylinositol 3-Kinase><2 year old><2 years of age><Affect><After Care><After-Treatment><Aftercare><Alleles><Allelic Loss><Allelomorphs><Anabolism><Anatomic Abnormality><Anatomical Abnormality><Assay><Autoregulation><Binding><Bioassay><Biological Assay><Blood Plasma><Body Tissues><Bone Chondroma><Bone Growth><Cartilage><Cartilaginous Tissue><Cartilaginous exostosis><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Child><Child Youth><Children (0-21)><Chondrocytes><Chondrogenesis><Chondrosteoma><Chondrosteomas><Clinical><Clinical Data><Clinical Trials><Compensation><DNA mutation><Data><Defect><Deformity><Diaphyseal Aclasis><Diet><Disease><Disease Progression><Disorder><Dose><Drug Kinetics><Drugs><EC 2.4><EXT1><EXT1 gene><Ectopic Ossification><Elements><Engineering><Enhancers><Enzyme Gene><Enzymes><Epiphyseal Plate><Epiphysial cartilage><Exostoses><Exostoses (multiple) 1><Exostosin-1><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Familial Exostoses><Femur><Fibrodysplasia Ossificans Progressiva><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Frequencies><Future><Gene Alteration><Gene Mutation><Generalized Growth><Genes><Genetic><Genetic Change><Genetic Diseases><Genetic defect><Genetic mutation><Glycoside Transferases><Goals><Growth><Growth Agents><Growth Factor><Growth Plate><Growth Substances><Heparan Sulfate><Heparan Sulfate Biosynthesis><Heparitin Sulfate><Hereditary Deforming Chondrodysplasia><Hereditary Multiple Exostoses><Heterotopic Ossification><Histology><Homeostasis><Human><Intracellular Communication and Signaling><Libraries><Link><Location><Loss of Heterozygosity><Malignant><Malignant - descriptor><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Medication><Metastatic breast cancer><Mice><Mice Mammals><Modern Man><Molecular Interaction><Monitor><Multiple Cartilaginous Exostoses><Multiple Exostoses><Multiple Osteochondromas><Murine><Mus><Mutation><Names><Oral><Oral Administration><Oral Drug Administration><Orphan Disease><Osseous Chondroma><Osteocartilaginous Exostosis><Osteochondroma><Outcome><PI-3 Kinase><PI-3K/AKT><PI3-Kinase><PI3CG><PI3K-Alpha><PI3K/AKT><PI3KGamma><PI3k><PIK3><PIK3-Alpha><PIK3CA><PIK3CA gene><PIK3CG><PIK3CG gene><PIQRAY><Pain Control><Pain Therapy><Pain management><Pathologic><Pathologic Ossification><Pathological Ossification><Pathway interactions><Patients><Pharmaceutical Preparations><Pharmacodynamics><Pharmacokinetics><Phosphatidylinositol 3-Kinase><Phosphatidylinositol 3-Kinase, Catalytic, 110-kD, Alpha><Phosphatidylinositol 3-Kinase, Catalytic, Alpha><Phosphatidylinositol-3-OH Kinase><Phosphoinositide 3-Hydroxykinase><Physiological Homeostasis><Plasma><Plasma Serum><Preclinical data><Process><Proliferating><Property><Proteins Growth Factors><PtdIns 3-Kinase><Public Health><QOL improvement><Rare Diseases><Rare Disorder><Regimen><Reporter><Research><Reticuloendothelial System, Serum, Plasma><Ribs><Safety><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Surgical Management><System><Testing><Therapeutic><Therapeutic Effect><Tissue Growth><Tissues><Toxicology><Treatment Efficacy><Type I Phosphatidylinositol Kinase><Type III Phosphoinositide 3-Kinase><age 2><age 2 years><aged 2 years><aged two years><alpelisib><autosome><biological signal transduction><biosynthesis><bone><chronic pain><clinical applicability><clinical application><compound repositioning><compound repurposing><determine efficacy><diets><disease model><disorder model><drug candidate><drug development><drug repositioning><drug repurposing><drug/agent><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><functional restoration><gene defect><genetic condition><genetic disorder><genome mutation><glycosyltransferase><heparan sulfate copolymerase EXT1><improvements in QOL><improvements in quality of life><in vivo><inhibitor><innovate><innovation><innovative><insight><intervention efficacy><intraoral drug delivery><intraperitoneal><kids><long bone><loss of function><luminescence><metastatic breast tumor><metastatic mammary cancer><metastatic mammary tumor><mouse model><murine model><mutant><mutant allele><myositis ossificans progressiva><name><named><naming><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic uses for existing drugs><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><new use of drug><new uses for an approved drug><new uses for existing drugs><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><ontogeny><orphan disorder><p110-Alpha><pain intervention><pain treatment><pathway><pharmacologic><pharmacological repurposing><post treatment><pre-clinical study><preclinical findings><preclinical information><preclinical study><prevent><preventing><programs><progressive myositis ossificans><progressive ossifying myositis><quality of life improvement><repositioning approved drugs><repositioning existing drugs><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><restore function><restore functionality><restore lost function><rib bone structure><side effect><skeletal><skeletal disease><skeletal disorder><small molecule><success><therapeutic efficacy><therapeutic repositioning><therapeutic repurposing><therapy efficacy><two year old><two years of age><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Xin Chen

UNIVERSITY OF HAWAII AT MANOA, HONOLULU, HI

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$402,401
FY 2026

Project Title

Therapeutic Targeting of Upregulated BAP1 in Human Hepatocellular Carcinoma

Grant Number:

1R21CA303374-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Hepatocellular carcinoma (HCC), commonly known as liver cancer, is one of the leading causes of cancer- related death worldwide. Due to its lack of specific symptoms, HCC is frequently diagnosed at the advanced stage, when the treatment options are quite limited. Currently, immunotherapy is...

Research Terms

<Ablation><Address><Allelic Loss><BAP1 gene><BRCA1 Associated Protein-1><BRCA1-Associated Protein 1><CRISPR><CRISPR/Cas system><Cancer Cause><Cancer Center><Cancer Etiology><Cancers><Carcinoma Cell><Causality><Cellular Expansion><Cellular Growth><Cerebral Protein-13><Cerebral Protein-6><Cessation of life><Cholesterol Homeostasis><Clustered Regularly Interspaced Short Palindromic Repeats><DNA mutation><Data><Data Bases><Databases><Death><Diagnosis><Ethnic Origin><Ethnicity><Etiology><Funding Mechanisms><Genes><Genetic Change><Genetic defect><Genetic mutation><Germ Lines><HCC cell><HCC cell line><Hawaii><Hepatic Cancer><Hepatocarcinoma><Hepatocarcinoma model><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Human><Immune mediated therapy><Immunologically Directed Therapy><Immunotherapy><KO mice><Knock-out Mice><Knockout Mice><Liver Cells Carcinoma><Loss of Heterozygosity><Malignant Epithelial Cell><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of liver><Messenger RNA><Mice><Mice Mammals><Modern Man><Murine><Mus><Mutation><Null Mouse><Oncogenic><Pathogenesis><Pathology><Pathway interactions><Patients><Pattern><Plasmids><Pre-Clinical Model><Preclinical Models><Primary Malignant Neoplasm of Liver><Primary carcinoma of the liver cells><Primary liver cancer><RNA Seq><RNA sequencing><RNAseq><Research Specimen><Risk><Role><Sampling><Solid><Specimen><Staining method><Stains><Survival Rate><Symptoms><Syndrome><Testing><Therapeutic><Treatment Efficacy><Tumor Suppressor Proteins><Universities><c myc><c-myc Genes><causation><cell growth><cholesterol biosynthesis><cholesterol metabolism><cmyc><data base><determine efficacy><disease causation><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><genome mutation><hepatocellular carcinoma cancer model><hepatocellular carcinoma cell line><hepatocellular carcinoma model><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><inhibitor><innovate><innovation><innovative><intervention efficacy><liver cancer><liver cancer model><liver carcinoma><liver development><liver malignancy><loss of function><loss of function mutation><mRNA><malignancy><malignant liver tumor><neoplasm/cancer><novel><pathway><protein expression><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapeutic target><therapy efficacy><transcriptome sequencing><transcriptomic sequencing><tumor><tumor suppressor><v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog>
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Weihua Guan

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$399,852
FY 2026

Project Title

Circulating senescent proteins and their trajectories in relation to age-related outcomes in cancer survivors

Grant Number:

1R21CA301160-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Cancer survivors experience multiple age-related diseases that occur at earlier age than in cancer-free persons. Thus, cancer survivors age faster than those without cancer, and the accelerated aging is driven by prolonged cellular senescence. The detrimental role of senescence is mainly ex...

Research Terms

<Address><Age><Aging><Assay><Atherosclerosis Risk in Communities><Atlases><Bioassay><Biological Aging><Biological Assay><Biometrics><Biometry><Biostatistics><Blood><Blood Reticuloendothelial System><Breast><Cancer Survivor><Cancer Survivorship><Cancer Treatment><Cancers><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Caucasian male><Caucasian men><Cell Aging><Cell Senescence><Cell-Extracellular Matrix><Cellular Aging><Cellular Senescence><Cessation of life><Characteristics><Chemotactic Cytokines><Chronic Disease><Chronic Illness><Circulation><Clinical><Clinical Trials><Cognition><Cohort Studies><Coin><Collection><Colon or Rectum><Colorectal><Data><Death><Development><Diagnosis><Drugs><ECM><Eligibility><Eligibility Determination><Esteroproteases><Extracellular Matrix><Future><Growth Agents><Growth Factor><Growth Substances><Health><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Heart Vascular><Homologous Chemotactic Cytokines><In Vitro><Individual><Inflammation><Insulin Resistance><Intercrines><Interleukins><Intervention><Knowledge><Lead><Life Expectancy><Life Style><Lifestyle><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Medicare><Medication><Metabolic><Molecular Epidemiology of Cancer><Monitor><Morbidity><Oncology><Oncology Cancer><Outcome><Participant><Pb element><Peptidases><Peptide Hydrolases><Persons><Pharmaceutical Preparations><Phenotype><Population Study><Predictive Value><Principal Component Analyses><Principal Component Analysis><Production><Prospective cohort><Prostate><Prostate Gland><Prostatic Gland><Protease Gene><Proteases><Protein Secretion><Proteinases><Proteins><Proteins Growth Factors><Proteolytic Enzymes><Proteomics><Protocol Screening><Publishing><Race><Races><Renal function><Replicative Senescence><Reporting><Roentgen Rays><Role><SIS cytokines><Screening for cancer><Senotherapy><Stage at Diagnosis><Supportive Therapy><Supportive care><Survivors><Testing><Therapeutic Intervention><Time><Title 18><Training><Visit><Vulnerable Populations><Woman><Work><X-Radiation><X-Ray Radiation><X-ray><Xray><accelerated aging><accelerated biological age><accelerated biological aging><adverse consequence><adverse outcome><age acceleration><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age related pathways><age specific><age-related disease><age-related disorder><age-related impairment><ages><aging associated mechanism><aging biological marker><aging biomarker><aging marker><aging mechanism><aging pathway><aging process><aging related mechanism><aging related pathways><anti-cancer therapy><aptamer><biological mechanism of age><biological pathways of age><biological process of age><black male><black man><black men><cancer care><cancer diagnosis><cancer epidemiology><cancer registry><cancer therapy><cancer-directed therapy><cardiovascular risk><cardiovascular risk factor><chemoattractant cytokine><chemokine><chronic disorder><circulating biomarkers><circulating markers><circulatory system><co-morbid><co-morbidity><cohort research study><cohort survey><colorectum><comorbidity><cost efficient><cross-sectional investigation><cross-sectional research><cytokine><death risk><developmental><drug/agent><early cancer detection><experience><frailty><health insurance for disabled><heavy metal Pb><heavy metal lead><high risk><improved><indexing><insulin resistant><insulin tolerance><intervention therapy><investigate cross-sectional><kidney function><malignancy><mechanism regulating aging><mechanisms involved in aging><mortality><mortality risk><multidisciplinary><neoplasm registry><neoplasm/cancer><novel><pace of aging><pace of biological aging><pathway involved in aging><population based><population research study><population survey><population-based study><population-level study><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><premature><prematurity><racial><racial background><racial origin><rate of aging><rate of biological aging><rate of change><replicative aging><risk stratification><screening cancer patients><senescence><senescence and its associated secretory phenotype><senescence associated secretome><senescence associated secretory factors><senescence associated secretory pathway><senescence associated secretory phenotype><senescence associated secretory program><senescence associated secretory proteins><senescent><senescent associated secretome><senescent associated secretory phenotype><senescent cell><sex><social role><speed of aging><speed of the aging><stratify risk><study cross-sectional><survey cross-sectional><therapeutic induction of senescence><therapy caused senescence><therapy induced cell senescence><therapy induced cellular senescence><therapy induced senescence><trait><treatment induced senescence><vulnerable group><vulnerable individual><vulnerable people><white male><white men>
View Full Project Details on NIH Reporter
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Anna Prizment

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$399,852
FY 2026

Project Title

Circulating senescent proteins and their trajectories in relation to age-related outcomes in cancer survivors

Grant Number:

1R21CA301160-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

ABSTRACT Cancer survivors experience multiple age-related diseases that occur at earlier age than in cancer-free persons. Thus, cancer survivors age faster than those without cancer, and the accelerated aging is driven by prolonged cellular senescence. The detrimental role of senescence is mainly ex...

Research Terms

<Address><Age><Aging><Assay><Atherosclerosis Risk in Communities><Atlases><Bioassay><Biological Aging><Biological Assay><Biometrics><Biometry><Biostatistics><Blood><Blood Reticuloendothelial System><Breast><Cancer Survivor><Cancer Survivorship><Cancer Treatment><Cancers><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Caucasian male><Caucasian men><Cell Aging><Cell Senescence><Cell-Extracellular Matrix><Cellular Aging><Cellular Senescence><Cessation of life><Characteristics><Chemotactic Cytokines><Chronic Disease><Chronic Illness><Circulation><Clinical><Clinical Trials><Cognition><Cohort Studies><Coin><Collection><Colon or Rectum><Colorectal><Data><Death><Development><Diagnosis><Drugs><ECM><Eligibility><Eligibility Determination><Esteroproteases><Extracellular Matrix><Future><Growth Agents><Growth Factor><Growth Substances><Health><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Heart Vascular><Homologous Chemotactic Cytokines><In Vitro><Individual><Inflammation><Insulin Resistance><Intercrines><Interleukins><Intervention><Knowledge><Lead><Life Expectancy><Life Style><Lifestyle><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Measures><Medicare><Medication><Metabolic><Molecular Epidemiology of Cancer><Monitor><Morbidity><Oncology><Oncology Cancer><Outcome><Participant><Pb element><Peptidases><Peptide Hydrolases><Persons><Pharmaceutical Preparations><Phenotype><Population Study><Predictive Value><Principal Component Analyses><Principal Component Analysis><Production><Prospective cohort><Prostate><Prostate Gland><Prostatic Gland><Protease Gene><Proteases><Protein Secretion><Proteinases><Proteins><Proteins Growth Factors><Proteolytic Enzymes><Proteomics><Protocol Screening><Publishing><Race><Races><Renal function><Replicative Senescence><Reporting><Roentgen Rays><Role><SIS cytokines><Screening for cancer><Senotherapy><Stage at Diagnosis><Supportive Therapy><Supportive care><Survivors><Testing><Therapeutic Intervention><Time><Title 18><Training><Visit><Vulnerable Populations><Woman><Work><X-Radiation><X-Ray Radiation><X-ray><Xray><accelerated aging><accelerated biological age><accelerated biological aging><adverse consequence><adverse outcome><age acceleration><age associated><age associated disease><age associated disorder><age associated impairment><age correlated><age dependent><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related human disease><age related pathways><age specific><age-related disease><age-related disorder><age-related impairment><ages><aging associated mechanism><aging biological marker><aging biomarker><aging marker><aging mechanism><aging pathway><aging process><aging related mechanism><aging related pathways><anti-cancer therapy><aptamer><biological mechanism of age><biological pathways of age><biological process of age><black male><black man><black men><cancer care><cancer diagnosis><cancer epidemiology><cancer registry><cancer therapy><cancer-directed therapy><cardiovascular risk><cardiovascular risk factor><chemoattractant cytokine><chemokine><chronic disorder><circulating biomarkers><circulating markers><circulatory system><co-morbid><co-morbidity><cohort research study><cohort survey><colorectum><comorbidity><cost efficient><cross-sectional investigation><cross-sectional research><cytokine><death risk><developmental><drug/agent><early cancer detection><experience><frailty><health insurance for disabled><heavy metal Pb><heavy metal lead><high risk><improved><indexing><insulin resistant><insulin tolerance><intervention therapy><investigate cross-sectional><kidney function><malignancy><mechanism regulating aging><mechanisms involved in aging><mortality><mortality risk><multidisciplinary><neoplasm registry><neoplasm/cancer><novel><pace of aging><pace of biological aging><pathway involved in aging><population based><population research study><population survey><population-based study><population-level study><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><premature><prematurity><racial><racial background><racial origin><rate of aging><rate of biological aging><rate of change><replicative aging><risk stratification><screening cancer patients><senescence><senescence and its associated secretory phenotype><senescence associated secretome><senescence associated secretory factors><senescence associated secretory pathway><senescence associated secretory phenotype><senescence associated secretory program><senescence associated secretory proteins><senescent><senescent associated secretome><senescent associated secretory phenotype><senescent cell><sex><social role><speed of aging><speed of the aging><stratify risk><study cross-sectional><survey cross-sectional><therapeutic induction of senescence><therapy caused senescence><therapy induced cell senescence><therapy induced cellular senescence><therapy induced senescence><trait><treatment induced senescence><vulnerable group><vulnerable individual><vulnerable people><white male><white men>
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Piyush Koria

UNIVERSITY OF SOUTH FLORIDA, TAMPA, FL

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$353,354
FY 2026

Project Title

Protease Resistant Growth Factor Nanoparticles for Chronic Wound Healing

Grant Number:

5R33AG077426-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2023

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Older adults are extremely susceptible to chronic wounds such as venous leg ulcers (VLUs), diabetic foot ulcers (DFUs) and pressure ulcers (PUs). These wounds are difficult to treat and often drastic operative interventions such as amputations or free flaps with a clear loss of funct...

Research Terms

<Affect><American><Amputation><Animal Model><Animal Models and Related Studies><Animals><Bed Sores><Bedsore><Biodistribution><Biological Agent><Biological Products><Clinic><Collection><Data><Development><Diabetic Foot Ulcer><Diabetic mouse><Drug Kinetics><Elderly><Environment><Esteroproteases><Family suidae><Fibroblasts><Granulocyte Elastase><Growth Agents><Growth Factor><Growth Substances><Half-Life><Health Care Systems><Human><Inflammation><Intervention><Investigators><Leg Ulcer><Leukocyte Elastase><Liquid substance><Lower Extremity Ulcer><Lysosomal Elastase><MMPs><Matrix Metalloproteinases><Mediating><Mice><Mice Mammals><Modern Man><Morbidity><Murine><Mus><Neutrophil Elastase><PMN Elastase><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Peptidases><Peptide Hydrolases><Pharmacokinetics><Phase><Pigs><Pilot Projects><Polymorphonuclear Leukocyte Elastase><Preclinical data><Predisposition><Pressure Sore><Pressure Ulcer><Protease Gene><Proteases><Proteinases><Proteins Growth Factors><Proteolytic Enzymes><Public Health><QOL><Quality of life><Recombinants><Research Personnel><Researchers><Resistance><Safety><Side><Site><Suidae><Susceptibility><Swine><Technology><Testing><Therapeutic><Translating><Translations><Venous><Work><Wound Repair><Wound models><advanced age><aged><aged animal><aged animals><aged mice><aged mouse><animal old age><biologics><biopharmaceutical><biotherapeutic agent><chronic skin wound><chronic wound><cost><decubitus ulcer><determine efficacy><developmental><diabetes mouse model><diabetic foot wound><dosage><economic impact><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><elderly animal><elderly mice><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><first in man><first-in-human><fluid><geriatric><healing><improved><ineffective therapies><ineffective treatment><innovate><innovation><innovative><juvenile animal><liquid><loss of function><model of animal><mortality><mouse model><murine model><nano particle><nano-sized particle><nanoparticle><nanosized particle><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><old animals><old mice><older adult><older adulthood><pathway><patient oriented outcomes><pilot study><porcine><pre-clinical><pre-clinical development><preclinical><preclinical development><preclinical findings><preclinical information><pressure injury><re-epithelialization><resistant><senior citizen><suid><tissue wound><translation><wound><wound assessment><wound care><wound healing><wound healing models><wound monitoring><wound recovery><wound resolution><wounding><wounds><young animal>
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Amelia Maiga

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$262,500
FY 2026

Project Title

Novel Prediction of Recovery of Consciousness in Acute Traumatic Brain Injury

Grant Number:

1R21NS142653-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Traumatic brain injury (TBI) is a major cause of death and disability in the U.S. and beyond. More than half of TBI deaths occur in the context of acute withdrawal of life-sustaining treatment (WLST). The decision to continue towards neurorehabilitation versus transition to...

Research Terms

<1-Aminoadamantane><Academy><Acceleration><Acquired brain injury><Acute><Adamantylamine><Address><Age><Amantadine><Anesthesia><Anesthesia procedures><Anoxia><Apoplexy><BRAIN initiative><Behavioral><Brain><Brain Injuries><Brain Nervous System><Brain Research through Advancing Innovative Neurotechnologies initiative><Brain Trauma><Brain Vascular Accident><Caring><Cause of Death><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cessation of life><Clinical><Collaborations><Coma><Comatose><Conscious><Consciousness><Consciousness Disorders><Critical Care><Death><Decision Making><Deep Brain Stimulation><Detection><Development><Diprivan><Disoprofol><EEG><Electroencephalogram><Electroencephalography><Encephalon><Engineering><Enrollment><Equation><Female><Future><Goals><Injury><Intensive Care Units><Investigators><Life><Light><Measurable><Measures><Methods><Modeling><Multiple Injuries><Multiple Trauma><NIH><National Institutes of Health><Neuro rehabilitation><Neurologist><Neurorehabilitation><Participant><Patients><Patients with traumatic brain injury><Pattern><Persistent Unawareness State><Persistent Vegetative State><Photoradiation><Propofol><Prospective Studies><Recovery><Recovery of Function><Research Personnel><Research Priority><Researchers><Science><Scientist><Seasons><Stroke><Surgeon><TBI Patients><Testing><Translating><Trauma><Traumatic Brain Injury><Uncertainty><United States National Institutes of Health><Withdrawal><Work><ages><brain attack><brain damage><brain injury response><brain-injured><candidate identification><cerebral vascular accident><cerebrovascular accident><density><developmental><diagnostic tool><disability><doubt><enroll><expectation><functional independence><functional outcomes><functional recovery><functional status><improved><indexing><injuries><neurological rehab><neurological rehabilitation><neurophysiological><neurophysiology><neurorehab><neurorehabilitative><novel><polytrauma><predictive tools><premature><prematurity><prevent><preventing><prognosis model><prognostic><prognostic model><prognostication><prospective><prospective research study><prospective survey><response><response to brain injury><skills><stroked><strokes><tool><trauma centers><traumatic brain damage><traumatic brain injury patients><♀>
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Justin Jeffers

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$256,340
FY 2026

Project Title

AR-CPR: Refinement and Large-Scale Simulation-Based Testing of a Novel Augmented Reality Point of Care Chest Compression Feedback System.

Grant Number:

5R33HS029372-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

AHRQ

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Each year, 20,000 children in the United States suffer a cardiac arrest, but only 17-50% survive. Survival is associated with high-quality chest compressions. Yet, healthcare providers adhere to the rate and depth guidelines recommended by the Pediatric Advanced Life Support (PALS) program for cardi...

Research Terms

<0-11 years old><AHCPR><AHRQ><Address><Adherence><Agency for Health Care Policy and Research><Agency for Healthcare Research and Quality><Ambulances><Asystole><Augmented Reality><Automated External Defibrillator><Cardiac Arrest><Cardiopulmonary Resuscitation><Caring><Chest><Chest Wall><Chest wall structure><Child><Child Youth><Childhood><Children (0-21)><Clinical><Collaborations><Community Hospitals><Computer software><Data><Data Analyses><Data Analysis><Detection><Development><Devices><Education><Educational aspects><Emotional Stress><Engineering><Equity><Evaluation><Feedback><Future><Goals><Guideline Adherence><Guidelines><Health Care Providers><Health Care Technology><Health Personnel><Health Technology><Heart><Heart Arrest><Hospitals><Household><Human Resources><Inequity><Interdisciplinary Research><Interdisciplinary Study><International><Intervention><Interview><Investigators><Laboratories><Life><Location><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Manpower><Measurement><Measures><Medical><Methods><Mission><Multidisciplinary Collaboration><Multidisciplinary Research><Performance><Physics><Position><Positioning Attribute><Provider><QOC><Quality of Care><Randomized><Recommendation><Research><Research Design><Research Personnel><Research Resources><Researchers><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Resuscitation><Schools><Software><Structure><Study Type><System><Testing><Thorace><Thoracic><Thoracic Wall><Thorax><Time><Training><United States><United States Agency for Health Care Policy and Research><United States Agency for Healthcare Research and Quality><Universities><Variant><Variation><Virtual and Augmented reality><Visual><Work><X-reality><cardiac resuscitation><care delivery><clinical care><community setting><data interpretation><design><designing><developmental><digital health><experience><extended reality><head mounted device><head mounted display><health care personnel><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><heart resuscitation><improved><improved outcome><innovate><innovation><innovative><kids><large scale simulation><medical care providers><medical college><medical personnel><medical schools><multidisciplinary><new approaches><novel><novel approaches><novel strategies><novel strategy><pediatric><personnel><point of care><portability><programs><randomisation><randomization><randomly assigned><school of medicine><sensor><simulation><study design><tool><treatment provider><usability><user-friendly><visual feedback><wireless communication><youngster>
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Keith Kleinman

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$256,340
FY 2026

Project Title

AR-CPR: Refinement and Large-Scale Simulation-Based Testing of a Novel Augmented Reality Point of Care Chest Compression Feedback System.

Grant Number:

5R33HS029372-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

AHRQ

Start Date:

4/1/2023

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Each year, 20,000 children in the United States suffer a cardiac arrest, but only 17-50% survive. Survival is associated with high-quality chest compressions. Yet, healthcare providers adhere to the rate and depth guidelines recommended by the Pediatric Advanced Life Support (PALS) program for cardi...

Research Terms

<0-11 years old><AHCPR><AHRQ><Address><Adherence><Agency for Health Care Policy and Research><Agency for Healthcare Research and Quality><Ambulances><Asystole><Augmented Reality><Automated External Defibrillator><Cardiac Arrest><Cardiopulmonary Resuscitation><Caring><Chest><Chest Wall><Chest wall structure><Child><Child Youth><Childhood><Children (0-21)><Clinical><Collaborations><Community Hospitals><Computer software><Data><Data Analyses><Data Analysis><Detection><Development><Devices><Education><Educational aspects><Emotional Stress><Engineering><Equity><Evaluation><Feedback><Future><Goals><Guideline Adherence><Guidelines><Health Care Providers><Health Care Technology><Health Personnel><Health Technology><Heart><Heart Arrest><Hospitals><Household><Human Resources><Inequity><Interdisciplinary Research><Interdisciplinary Study><International><Intervention><Interview><Investigators><Laboratories><Life><Location><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Manpower><Measurement><Measures><Medical><Methods><Mission><Multidisciplinary Collaboration><Multidisciplinary Research><Performance><Physics><Position><Positioning Attribute><Provider><QOC><Quality of Care><Randomized><Recommendation><Research><Research Design><Research Personnel><Research Resources><Researchers><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Resuscitation><Schools><Software><Structure><Study Type><System><Testing><Thorace><Thoracic><Thoracic Wall><Thorax><Time><Training><United States><United States Agency for Health Care Policy and Research><United States Agency for Healthcare Research and Quality><Universities><Variant><Variation><Virtual and Augmented reality><Visual><Work><X-reality><cardiac resuscitation><care delivery><clinical care><community setting><data interpretation><design><designing><developmental><digital health><experience><extended reality><head mounted device><head mounted display><health care personnel><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><heart resuscitation><improved><improved outcome><innovate><innovation><innovative><kids><large scale simulation><medical care providers><medical college><medical personnel><medical schools><multidisciplinary><new approaches><novel><novel approaches><novel strategies><novel strategy><pediatric><personnel><point of care><portability><programs><randomisation><randomization><randomly assigned><school of medicine><sensor><simulation><study design><tool><treatment provider><usability><user-friendly><visual feedback><wireless communication><youngster>
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Ravi Bharadwaj

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$251,250
FY 2026

Project Title

Role of SLC46A3 in the pathogenesis of inflammatory bowel disease

Grant Number:

1R21AI193666-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Inflammatory bowel diseases (IBD), including Crohn’s disease (CD), remain a significant clinical challenge with increasing prevalence, affecting millions worldwide despite recent therapeutic advances. Loss-of-function polymorphisms in the Nod2 gene are strongly associated with CD, which has long cre...

Research Terms

<21+ years old><Acetylmuramyl-Alanyl-Isoglutamine><Adult><Adult Human><Affect><Agonist><Animals><Automobile Driving><Autophagocytosis><Autoregulation><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Bacteria><Bone Marrow><Bone Marrow Reticuloendothelial System><C rodentium><C. rodentium><Carrier Proteins><Causality><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><Cell Wall><CellLine><Cells><Chemistry><Chronic><Citrobacter freundii Biotype 4280><Citrobacter rodentium><Clinical><Colitis><Colon><Communication><Complex><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><Cytosol><DNA mutation><Data><Disease><Disease Progression><Disorder><Drosophila><Drosophila genus><Epithelial Cells><Epithelium><Etiology><Exhibits><Extracellular Signal-Regulated Kinase Gene><Family><Future><GI microbiome><GI microbiota><Gastrointestinal Diseases><Gastrointestinal microbiota><Genes><Genetic Change><Genetic Polymorphism><Genetic defect><Genetic mutation><Genetic study><Goals><Goblet Cells><Granulomatous Enteritis><Gut Epithelium><Homeostasis><Human><Immune><Immunes><Immunologic Receptors><Immunological Receptors><Impairment><Infection><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Inflammatory Response><Innate Immune System><Insecta><Insects><Insects Invertebrates><Intestinal><Intestines><Intracellular Communication and Signaling><Investigation><KO mice><Kinases><Knock-out Mice><Knockout Mice><Link><Literature><MAP Kinase Gene><MAPK><Macrophage><Mammalia><Mammals><Mediating><Mice><Mice Mammals><Mitogen-Activated Protein Kinase Gene><Modern Man><Molecular><Muramyl Dipeptide><Murein><Murine><Mus><Mutation><Myeloid Cells><Mφ><Null Mouse><Pathogenesis><Pathology><Pathway interactions><Patients><Peptidoglycan><Phenotype><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiological><Physiological Homeostasis><Predisposition><Prevalence><Production><Protein Kinase Interaction><Receptor Protein><Receptor-Interacting Protein><Regulation><Reporting><Research><Risk><Role><Route><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Sodium Dextran Sulfate><Strains Cell Lines><Susceptibility><Therapeutic><Therapeutic Intervention><Transphosphorylases><Transport Protein Gene><Transport Proteins><Transporter Protein><adulthood><alpha-Defensins><anti-microbial peptide><autophagy><biological signal transduction><bowel><causation><colitis mouse model><colitis murine model><cultured cell line><cytokine><digestive tract microbiome><disease causation><driving><dysbacteriosis><dysbiosis><dysbiotic><eleocolitis><enteric microbial community><enteric microbiome><enteric microbiota><fruit fly><gastrointestinal disorder><gastrointestinal epithelium><gastrointestinal microbial flora><gastrointestinal microbiome><gene interaction><genome mutation><gut community><gut flora><gut homeostasis><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbiome><immune receptor><in vivo><inflammatory disease of the intestine><inflammatory disorder of the intestine><intervention therapy><intestinal autoinflammation><intestinal barrier><intestinal biome><intestinal epithelium><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal mucosal barrier><intestinal tract microflora><keratinocyte><loss of function><microbial><microbial imbalance><microbiome><mouse colitis><mouse model><murine colitis><murine model><pathway><polymorphism><receptor><regional enteritis><sensor><social role><solute><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><uptake><α-Defensins>
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Neal Silverman

UNIV OF MASSACHUSETTS MED SCH WORCESTER, WORCESTER, MA

Exploratory lead · 40/100
Solid budget
Very recent
Active award
$251,250
FY 2026

Project Title

Role of SLC46A3 in the pathogenesis of inflammatory bowel disease

Grant Number:

1R21AI193666-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Inflammatory bowel diseases (IBD), including Crohn’s disease (CD), remain a significant clinical challenge with increasing prevalence, affecting millions worldwide despite recent therapeutic advances. Loss-of-function polymorphisms in the Nod2 gene are strongly associated with CD, which has long cre...

Research Terms

<21+ years old><Acetylmuramyl-Alanyl-Isoglutamine><Adult><Adult Human><Affect><Agonist><Animals><Automobile Driving><Autophagocytosis><Autoregulation><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Bacteria><Bone Marrow><Bone Marrow Reticuloendothelial System><C rodentium><C. rodentium><Carrier Proteins><Causality><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><Cell Wall><CellLine><Cells><Chemistry><Chronic><Citrobacter freundii Biotype 4280><Citrobacter rodentium><Clinical><Colitis><Colon><Communication><Complex><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><Cytosol><DNA mutation><Data><Disease><Disease Progression><Disorder><Drosophila><Drosophila genus><Epithelial Cells><Epithelium><Etiology><Exhibits><Extracellular Signal-Regulated Kinase Gene><Family><Future><GI microbiome><GI microbiota><Gastrointestinal Diseases><Gastrointestinal microbiota><Genes><Genetic Change><Genetic Polymorphism><Genetic defect><Genetic mutation><Genetic study><Goals><Goblet Cells><Granulomatous Enteritis><Gut Epithelium><Homeostasis><Human><Immune><Immunes><Immunologic Receptors><Immunological Receptors><Impairment><Infection><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Inflammatory Response><Innate Immune System><Insecta><Insects><Insects Invertebrates><Intestinal><Intestines><Intracellular Communication and Signaling><Investigation><KO mice><Kinases><Knock-out Mice><Knockout Mice><Link><Literature><MAP Kinase Gene><MAPK><Macrophage><Mammalia><Mammals><Mediating><Mice><Mice Mammals><Mitogen-Activated Protein Kinase Gene><Modern Man><Molecular><Muramyl Dipeptide><Murein><Murine><Mus><Mutation><Myeloid Cells><Mφ><Null Mouse><Pathogenesis><Pathology><Pathway interactions><Patients><Peptidoglycan><Phenotype><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiological><Physiological Homeostasis><Predisposition><Prevalence><Production><Protein Kinase Interaction><Receptor Protein><Receptor-Interacting Protein><Regulation><Reporting><Research><Risk><Role><Route><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Sodium Dextran Sulfate><Strains Cell Lines><Susceptibility><Therapeutic><Therapeutic Intervention><Transphosphorylases><Transport Protein Gene><Transport Proteins><Transporter Protein><adulthood><alpha-Defensins><anti-microbial peptide><autophagy><biological signal transduction><bowel><causation><colitis mouse model><colitis murine model><cultured cell line><cytokine><digestive tract microbiome><disease causation><driving><dysbacteriosis><dysbiosis><dysbiotic><eleocolitis><enteric microbial community><enteric microbiome><enteric microbiota><fruit fly><gastrointestinal disorder><gastrointestinal epithelium><gastrointestinal microbial flora><gastrointestinal microbiome><gene interaction><genome mutation><gut community><gut flora><gut homeostasis><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><host microbiome><immune receptor><in vivo><inflammatory disease of the intestine><inflammatory disorder of the intestine><intervention therapy><intestinal autoinflammation><intestinal barrier><intestinal biome><intestinal epithelium><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal mucosal barrier><intestinal tract microflora><keratinocyte><loss of function><microbial><microbial imbalance><microbiome><mouse colitis><mouse model><murine colitis><murine model><pathway><polymorphism><receptor><regional enteritis><sensor><social role><solute><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><uptake><α-Defensins>
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STEPHANIE S O'MALLEY

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 36/100
Above-average budget
Active award
Career award
$539,996
FY 2025

Project Title

Clinician Scientist Training Program (CSTP)

Grant Number:

5K12DA000167-34

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/1991

End Date:

7/31/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract The Yale Division of Addictions, Department of Psychiatry at Yale School of Medicine requests a 6th 5-year renewal for our Clinician Scientist Training Program, which has been providing intensive training in research methods for clinical and translational investigation of dr...

Research Terms

<Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Chemical Dependence><Clinical Research><Clinical Study><Conditioning Therapy><Development><Drug Addiction><Drug Dependence><Drug Dependency><Drug Therapy><Drug abuse><Evaluation><Exploratory/Developmental Grant><Faculty><Funding><Generations><Goals><Health Services Evaluation><Health Services Research><Individual><Investigators><Learning><Medical Care Research><Mentorship><Molecular Neurobiology><Pharmacological Treatment><Pharmacotherapy><Phase><Psychiatry><R-Series Research Projects><R01 Mechanism><R01 Program><R21 Mechanism><R21 Program><Research><Research Grants><Research Methodology><Research Methods><Research Personnel><Research Project Grants><Research Projects><Research Proposals><Research Support><Research Training><Researchers><Scientist><Substance abuse problem><Training><Training Programs><Translational Research><Translational Science><Work><abuse of drugs><abuse of substances><abuses drugs><addiction><addictive disorder><behavior intervention><behavioral intervention><career><clinical investigation><clinical training><develop therapy><developmental><drug intervention><drug treatment><early-career faculty><exploratory developmental study><innovate><innovation><innovative><interest><intervention development><medical college><medical schools><member><multidisciplinary><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pre-clinical><preclinical><programs><research and methods><school of medicine><services research><skills><substance abuse><therapy development><translation research><translational investigation><treatment development><virtual>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Marc N Potenza

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 36/100
Above-average budget
Active award
Career award
$539,996
FY 2025

Project Title

Clinician Scientist Training Program (CSTP)

Grant Number:

5K12DA000167-34

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/30/1991

End Date:

7/31/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract The Yale Division of Addictions, Department of Psychiatry at Yale School of Medicine requests a 6th 5-year renewal for our Clinician Scientist Training Program, which has been providing intensive training in research methods for clinical and translational investigation of dr...

Research Terms

<Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Chemical Dependence><Clinical Research><Clinical Study><Conditioning Therapy><Development><Drug Addiction><Drug Dependence><Drug Dependency><Drug Therapy><Drug abuse><Evaluation><Exploratory/Developmental Grant><Faculty><Funding><Generations><Goals><Health Services Evaluation><Health Services Research><Individual><Investigators><Learning><Medical Care Research><Mentorship><Molecular Neurobiology><Pharmacological Treatment><Pharmacotherapy><Phase><Psychiatry><R-Series Research Projects><R01 Mechanism><R01 Program><R21 Mechanism><R21 Program><Research><Research Grants><Research Methodology><Research Methods><Research Personnel><Research Project Grants><Research Projects><Research Proposals><Research Support><Research Training><Researchers><Scientist><Substance abuse problem><Training><Training Programs><Translational Research><Translational Science><Work><abuse of drugs><abuse of substances><abuses drugs><addiction><addictive disorder><behavior intervention><behavioral intervention><career><clinical investigation><clinical training><develop therapy><developmental><drug intervention><drug treatment><early-career faculty><exploratory developmental study><innovate><innovation><innovative><interest><intervention development><medical college><medical schools><member><multidisciplinary><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pre-clinical><preclinical><programs><research and methods><school of medicine><services research><skills><substance abuse><therapy development><translation research><translational investigation><treatment development><virtual>
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SUSAN L MITCHELL

HEBREW REHABILITATION CENTER FOR AGED, BOSTON, MA

Exploratory lead · 34/100
Above-average budget
Active award
$724,335
FY 2026

Project Title

Trial to Reduce Antimicrobial Use in Nursing home residents with Alzheimer's disease and other Dementias (TRAIN-AD)

Grant Number:

5R37AG032982-14

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2009

End Date:

12/31/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

The advanced stage of Alzheimer’s disease and other dementias is characterized by the onset infections, which prior work suggests are widely mismanaged. Antimicrobials are extensively prescribed, most often without evidence to support a bacterial infection. Antimicrobial exposure is the main factor ...

Research Terms

<AD and related dementia><AD dementia><AD related dementia><ADRD><Address><Advance Care Planning><Advance Health Care Planning><Algorithms><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><American><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Area><Bacterial Infections><Bladder><Bladder Urinary System><Blood><Blood Reticuloendothelial System><Booklets><Boston><Brochures><CXR><Caring><Catheterization><Clinical><Communicable Diseases><Consensus><Counseling><Data><Dementia><E-course><Education><Educational aspects><Event><Exposure to><Feedback><Foundations><Goals><Guidelines><Hospital Admission><Hospitalization><Hospitals><Infection><Infectious Diseases><Infectious Disorder><Intervention><Intervention Trial><Interventional trial><Lower Respiratory Tract Infection><Lower respiratory infection><Lower respiratory tract structure><MDR organism><MDR pathogen><Miscellaneous Antibiotic><Multi-Drug Resistance><Multidrug Resistance><Multiple Drug Resistance><Multiple Drug Resistant><NIH><National Institutes of Health><Nursing Homes><Nursing Research><Outcome><Palliative Care><Palliative Therapy><Palliative Treatment><Pamphlets><Parents><Patients><Persons><Phase><Pilot Projects><Policies><Population><Primary Senile Degenerative Dementia><Procedures><Prospective Studies><Provider><Proxy><Public Health><QOC><Quality of Care><Randomized, Controlled Trials><Records><Recurrence><Recurrent><Research><Research Infrastructure><Research Priority><Resistance><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistant to Multiple Drug><Resistant to multi-drug><Resistant to multidrug><Risk><Risk Factors><Thoracic Radiography><Training><United States National Institutes of Health><Urinary tract><Urinary tract infection><Urinary tract infectious disease><Work><advanced dementia><advanced directive><anti-microbial><antimicrobial><arm><bacteria infection><bacterial disease><care as usual><case-based><chest X ray><chest Xray><chest radiography><comfort care><cost><end of life care><improved><infection management><lower respiratory tract><lung radiography><medication administration><multi-component intervention><multi-drug resistant><multi-drug resistant organism><multi-drug resistant pathogen><multi-faceted intervention><multi-modal intervention><multicomponent intervention><multidrug resistant><multidrug resistant organism><multidrug resistant pathogen><multifaceted intervention><multimodal intervention><multiple drug resistant organism><multiple drug resistant pathogen><nursing home><nursing standards><online course><online curriculum><palliative intervention><parent><pathogen><patient centered><patient oriented><pilot study><primary degenerative dementia><primary outcome><programs><prospective><prospective research study><prospective survey><radiographic chest image><radiographic lung image><randomized control trial><resistant><secondary outcome><senile dementia of the Alzheimer type><thoracic radiogram><thorax radiography><treatment as usual><urinary><urinary bladder><urinary infection><usual care>
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ROBY PAUL BHATTACHARYYA

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 34/100
Above-average budget
Active award
$647,898
FY 2026

Project Title

Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection efforts

Grant Number:

5R33GM148826-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project summary: Sepsis is prevalent, costly, and deadly. In the U.S, sepsis accounts for 4% of hospitalizations, 13% of in-hospital healthcare expenditures, and 35% of in-hospital deaths. Although common, sepsis is often difficult to diagnose and treat effectively, since it is a syndrome defined ge...

Research Terms

<Address><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Biological><Blood><Blood Cells><Blood Reticuloendothelial System><Blood Sample><Blood monocyte><Blood specimen><CITE sequencing><CITE-seq><CITEseq><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Cellular Indexing of Transcriptomes and Epitopes by Sequencing><Cessation of life><Clinical><Clinical Data><Clinical Trials><Collection><Complex><Coupled><Cryofixation><Cryopreservation><Cryopreserved Cell><Data><Death><Development><Diagnosis><Disease><Disorder><Dysfunction><Enrollment><Evolution><Functional disorder><Gene Expression><Gene Transcription><Genes><Genetic Transcription><Genomics><Goals><Health Expenditures><Heterogeneity><Hospital Admission><Hospitalization><Hospitals><Human><IRB><IRBs><Immune><Immune mediated therapy><Immune response><Immunes><Immunochemical Immunologic><Immunologic><Immunologic Stimulation><Immunological><Immunological Stimulation><Immunologically><Immunologically Directed Therapy><Immunologics><Immunology><Immunostimulation><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunotherapy><In Vitro><Individual><Infection><Institutional Review Boards><Kinetics><Maps><Marrow monocyte><Measures><Methods><Modern Man><Morbidity><Multi-center studies><Multicenter Studies><Neurosciences><Non-Polyadenylated RNA><Oncology><Oncology Cancer><Organ><Organ failure><Outcome><Pathway interactions><Patients><Peripheral Blood Cell><Phase><Physiopathology><Population Heterogeneity><Procedures><Process><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Recovery><Reproducibility><Ribonucleic Acid><Sampling><Scientist><Sepsis><Site><Standardization><Stimulus><Syndrome><T-Cells><T-Lymphocyte><Techniques><Testing><Therapeutic Trials><Time><Transcription><Whole Blood><adjudication><adjudicative process and procedure><biologic><cell sorting><cell type><cellular indexing of transcriptomes and epitopes by single cell sequencing><clinical center><clinical investigation><clinical research site><clinical site><cohort><cold preservation><cold storage><cost><depository><developmental><disease heterogeneity><diverse populations><enroll><health care expenditure><heterogeneous population><host response><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><individuals with sepsis><insight><medical expenditure><monocyte><mortality><novel><pathophysiology><pathway><patient population><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><patients with sepsis><people with sepsis><population diversity><preservation><programs><repository><response><scRNA sequencing><scRNA-seq><sepsis groups><sepsis patients><sepsis population><sepsis subjects><septic group><septic individuals><septic patients><septic people><septic population><septic subject><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><subjects with sepsis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><thymus derived lymphocyte><transcriptome sequencing><transcriptomic sequencing><treatment effect><urinary sepsis><urosepsis>
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Michael Filbin

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 34/100
Above-average budget
Active award
$647,898
FY 2026

Project Title

Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection efforts

Grant Number:

5R33GM148826-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project summary: Sepsis is prevalent, costly, and deadly. In the U.S, sepsis accounts for 4% of hospitalizations, 13% of in-hospital healthcare expenditures, and 35% of in-hospital deaths. Although common, sepsis is often difficult to diagnose and treat effectively, since it is a syndrome defined ge...

Research Terms

<Address><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Biological><Blood><Blood Cells><Blood Reticuloendothelial System><Blood Sample><Blood monocyte><Blood specimen><CITE sequencing><CITE-seq><CITEseq><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Cellular Indexing of Transcriptomes and Epitopes by Sequencing><Cessation of life><Clinical><Clinical Data><Clinical Trials><Collection><Complex><Coupled><Cryofixation><Cryopreservation><Cryopreserved Cell><Data><Death><Development><Diagnosis><Disease><Disorder><Dysfunction><Enrollment><Evolution><Functional disorder><Gene Expression><Gene Transcription><Genes><Genetic Transcription><Genomics><Goals><Health Expenditures><Heterogeneity><Hospital Admission><Hospitalization><Hospitals><Human><IRB><IRBs><Immune><Immune mediated therapy><Immune response><Immunes><Immunochemical Immunologic><Immunologic><Immunologic Stimulation><Immunological><Immunological Stimulation><Immunologically><Immunologically Directed Therapy><Immunologics><Immunology><Immunostimulation><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunotherapy><In Vitro><Individual><Infection><Institutional Review Boards><Kinetics><Maps><Marrow monocyte><Measures><Methods><Modern Man><Morbidity><Multi-center studies><Multicenter Studies><Neurosciences><Non-Polyadenylated RNA><Oncology><Oncology Cancer><Organ><Organ failure><Outcome><Pathway interactions><Patients><Peripheral Blood Cell><Phase><Physiopathology><Population Heterogeneity><Procedures><Process><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Recovery><Reproducibility><Ribonucleic Acid><Sampling><Scientist><Sepsis><Site><Standardization><Stimulus><Syndrome><T-Cells><T-Lymphocyte><Techniques><Testing><Therapeutic Trials><Time><Transcription><Whole Blood><adjudication><adjudicative process and procedure><biologic><cell sorting><cell type><cellular indexing of transcriptomes and epitopes by single cell sequencing><clinical center><clinical investigation><clinical research site><clinical site><cohort><cold preservation><cold storage><cost><depository><developmental><disease heterogeneity><diverse populations><enroll><health care expenditure><heterogeneous population><host response><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><individuals with sepsis><insight><medical expenditure><monocyte><mortality><novel><pathophysiology><pathway><patient population><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><patients with sepsis><people with sepsis><population diversity><preservation><programs><repository><response><scRNA sequencing><scRNA-seq><sepsis groups><sepsis patients><sepsis population><sepsis subjects><septic group><septic individuals><septic patients><septic people><septic population><septic subject><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><subjects with sepsis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><thymus derived lymphocyte><transcriptome sequencing><transcriptomic sequencing><treatment effect><urinary sepsis><urosepsis>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

NATHAN I SHAPIRO

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 34/100
Above-average budget
Active award
$647,898
FY 2026

Project Title

Optimizing methods of clinical sample processing for scRNA-seq and mechanistic studies in sepsis to enable reliable, reproducible, and high-yield multi-center collection efforts

Grant Number:

5R33GM148826-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2023

End Date:

12/31/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Project summary: Sepsis is prevalent, costly, and deadly. In the U.S, sepsis accounts for 4% of hospitalizations, 13% of in-hospital healthcare expenditures, and 35% of in-hospital deaths. Although common, sepsis is often difficult to diagnose and treat effectively, since it is a syndrome defined ge...

Research Terms

<Address><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Biological><Blood><Blood Cells><Blood Reticuloendothelial System><Blood Sample><Blood monocyte><Blood specimen><CITE sequencing><CITE-seq><CITEseq><Cell Body><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Cellular Indexing of Transcriptomes and Epitopes by Sequencing><Cessation of life><Clinical><Clinical Data><Clinical Trials><Collection><Complex><Coupled><Cryofixation><Cryopreservation><Cryopreserved Cell><Data><Death><Development><Diagnosis><Disease><Disorder><Dysfunction><Enrollment><Evolution><Functional disorder><Gene Expression><Gene Transcription><Genes><Genetic Transcription><Genomics><Goals><Health Expenditures><Heterogeneity><Hospital Admission><Hospitalization><Hospitals><Human><IRB><IRBs><Immune><Immune mediated therapy><Immune response><Immunes><Immunochemical Immunologic><Immunologic><Immunologic Stimulation><Immunological><Immunological Stimulation><Immunologically><Immunologically Directed Therapy><Immunologics><Immunology><Immunostimulation><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunotherapy><In Vitro><Individual><Infection><Institutional Review Boards><Kinetics><Maps><Marrow monocyte><Measures><Methods><Modern Man><Morbidity><Multi-center studies><Multicenter Studies><Neurosciences><Non-Polyadenylated RNA><Oncology><Oncology Cancer><Organ><Organ failure><Outcome><Pathway interactions><Patients><Peripheral Blood Cell><Phase><Physiopathology><Population Heterogeneity><Procedures><Process><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Recovery><Reproducibility><Ribonucleic Acid><Sampling><Scientist><Sepsis><Site><Standardization><Stimulus><Syndrome><T-Cells><T-Lymphocyte><Techniques><Testing><Therapeutic Trials><Time><Transcription><Whole Blood><adjudication><adjudicative process and procedure><biologic><cell sorting><cell type><cellular indexing of transcriptomes and epitopes by single cell sequencing><clinical center><clinical investigation><clinical research site><clinical site><cohort><cold preservation><cold storage><cost><depository><developmental><disease heterogeneity><diverse populations><enroll><health care expenditure><heterogeneous population><host response><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive response><individuals with sepsis><insight><medical expenditure><monocyte><mortality><novel><pathophysiology><pathway><patient population><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><patients with sepsis><people with sepsis><population diversity><preservation><programs><repository><response><scRNA sequencing><scRNA-seq><sepsis groups><sepsis patients><sepsis population><sepsis subjects><septic group><septic individuals><septic patients><septic people><septic population><septic subject><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><subjects with sepsis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><thymus derived lymphocyte><transcriptome sequencing><transcriptomic sequencing><treatment effect><urinary sepsis><urosepsis>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

S. Abid Hussaini

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 34/100
Above-average budget
Active award
$507,214
FY 2026

Project Title

Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease

Grant Number:

1R21AG094050-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY The functions of long-noncoding RNAs (lncRNAs) as crucial regulators of transcription, epigenetic modifications, mRNA stability, localization, and translation indicate their potential involvement in Alzheimer's disease (AD) pathogenesis. Given the impairment of these fundamental cellular pr...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD dementia><AD model><AD pathology><AD risk><AD risk factor><APOE><Age><Aged 65 and Over><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's disease therapeutic><Alzheimer's pathology><Alzheimer's therapeutic><Alzheimers Dementia><Ammon Horn><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Apo-E><ApoE protein><Apolipoprotein E><Architecture><Astrocytes><Astrocytus><Astroglia><Autopsy><Aβ><BCEI><Brain><Brain Nervous System><Breast Cancer Estrogen-Inducible Sequence><Causality><Cell Body><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Classification><Code><Coding System><Cornu Ammonis><Cytology and Pathology><Cytopathology><Cytoplasm><DNA mutation><Data><Development><Disease><Disease Progression><Disorder><EOAD><Early Onset Alzheimer Disease><Electrophysiology><Electrophysiology (science)><Encephalon><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Functional RNA><Gastrointestinal Trefoil Protein PS2><Gene Expression><Gene Transcription><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genetic predisposing factor><Genotype><Glia><Glial Cells><Goals><Hippocampus><Hortega cell><Human><Impairment><KI mice><Knock-in><Knock-in Mouse><Kolliker's reticulum><Learning><Link><MT-bound tau><Mediating><Mediator><Memory><Mice><Mice Mammals><Microglia><Modeling><Modern Man><Modification><Molecular><Molecular Analysis><Morphology><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neural Transmission><Neuritic Plaques><Neurocyte><Neurofibrillary Tangles><Neuroglia><Neuroglial Cells><Neurons><Neurophysiology / Electrophysiology><Non-Polyadenylated RNA><Non-neuronal cell><Noncoding RNA><Nonneuronal cell><Nontranslated RNA><Nucleotides><Nucleus><Pathogenesis><Pathologic><Patients><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Primary Senile Degenerative Dementia><Process><Protein Biosynthesis><Protein Modification><Proteins><Proteomics><RNA><RNA Expression><RNA Gene Products><RNA based therapeutics><RNA based therapy><RNA therapy><Regulation><Reporting><Research><Ribonucleic Acid><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Role><Senile Plaques><Shapes><Spinal Column><Spine><Structure><Subcellular Process><Synapses><Synaptic><Synaptic Transmission><Systematics><TFF1><TFF1 gene><Tauopathies><Testing><Therapeutic><Transcription><Translational Regulation><Translations><Trefoil Factor 1><Untranslated RNA><Vertebral column><a beta peptide><abeta><above age 65><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><ages><alzheimer model><alzheimer risk><amyloid beta><amyloid beta plaque><amyloid-b plaque><amyloid-b protein><astrocytic glia><aβ plaques><backbone><beta amyloid fibril><causation><cored plaque><density><design><designing><developmental><diffuse plaque><disease causation><early onset><early onset AD><early onset Alzheimer's><electrophysiological><epigenetically><experiment><experimental research><experimental study><experiments><extracellular><gain of function><genetic analysis><genetic risk factor><genome mutation><gitter cell><hippocampal><human old age (65+)><hyper-phosphorylated tau><hyperphosphorylated tau><in vivo><inherited factor><insight><knockin><knockin mice><loss of function><mRNA Stability><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><model of animal><mouse model><murine model><necropsy><nerve cement><neural inflammation><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuroinflammation><neuroinflammatory><neuronal><neuropathologic tau><neuropathological tau><neuropsychiatric disease><neuropsychiatric disorder><noncoding><novel><over 65 years><pS2><perivascular glial cell><postmortem><presenilin><primary degenerative dementia><programs><protein synthesis><quantitative imaging><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social role><soluble amyloid precursor protein><synapse><synapse function><synaptic function><tangle><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic RNA><therapeutic agent development><therapeutic development><translation><τ Proteins><≥65 years>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sathya Puthanveettil

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 34/100
Above-average budget
Active award
$507,214
FY 2026

Project Title

Assessing the role of lncRNA SLAMR in the pathogenesis of Alzheimers disease

Grant Number:

1R21AG094050-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

SUMMARY The functions of long-noncoding RNAs (lncRNAs) as crucial regulators of transcription, epigenetic modifications, mRNA stability, localization, and translation indicate their potential involvement in Alzheimer's disease (AD) pathogenesis. Given the impairment of these fundamental cellular pr...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD dementia><AD model><AD pathology><AD risk><AD risk factor><APOE><Age><Aged 65 and Over><Alleles><Allelomorphs><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's disease therapeutic><Alzheimer's pathology><Alzheimer's therapeutic><Alzheimers Dementia><Ammon Horn><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β-Peptide><Amyloid β-Protein><Animal Model><Animal Models and Related Studies><Apo-E><ApoE protein><Apolipoprotein E><Architecture><Astrocytes><Astrocytus><Astroglia><Autopsy><Aβ><BCEI><Brain><Brain Nervous System><Breast Cancer Estrogen-Inducible Sequence><Causality><Cell Body><Cell Function><Cell Nucleus><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Classification><Code><Coding System><Cornu Ammonis><Cytology and Pathology><Cytopathology><Cytoplasm><DNA mutation><Data><Development><Disease><Disease Progression><Disorder><EOAD><Early Onset Alzheimer Disease><Electrophysiology><Electrophysiology (science)><Encephalon><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Functional RNA><Gastrointestinal Trefoil Protein PS2><Gene Expression><Gene Transcription><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genetic predisposing factor><Genotype><Glia><Glial Cells><Goals><Hippocampus><Hortega cell><Human><Impairment><KI mice><Knock-in><Knock-in Mouse><Kolliker's reticulum><Learning><Link><MT-bound tau><Mediating><Mediator><Memory><Mice><Mice Mammals><Microglia><Modeling><Modern Man><Modification><Molecular><Molecular Analysis><Morphology><Murine><Mus><Mutation><Nerve Cells><Nerve Unit><Neural Cell><Neural Transmission><Neuritic Plaques><Neurocyte><Neurofibrillary Tangles><Neuroglia><Neuroglial Cells><Neurons><Neurophysiology / Electrophysiology><Non-Polyadenylated RNA><Non-neuronal cell><Noncoding RNA><Nonneuronal cell><Nontranslated RNA><Nucleotides><Nucleus><Pathogenesis><Pathologic><Patients><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Primary Senile Degenerative Dementia><Process><Protein Biosynthesis><Protein Modification><Proteins><Proteomics><RNA><RNA Expression><RNA Gene Products><RNA based therapeutics><RNA based therapy><RNA therapy><Regulation><Reporting><Research><Ribonucleic Acid><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Role><Senile Plaques><Shapes><Spinal Column><Spine><Structure><Subcellular Process><Synapses><Synaptic><Synaptic Transmission><Systematics><TFF1><TFF1 gene><Tauopathies><Testing><Therapeutic><Transcription><Translational Regulation><Translations><Trefoil Factor 1><Untranslated RNA><Vertebral column><a beta peptide><abeta><above age 65><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><ages><alzheimer model><alzheimer risk><amyloid beta><amyloid beta plaque><amyloid-b plaque><amyloid-b protein><astrocytic glia><aβ plaques><backbone><beta amyloid fibril><causation><cored plaque><density><design><designing><developmental><diffuse plaque><disease causation><early onset><early onset AD><early onset Alzheimer's><electrophysiological><epigenetically><experiment><experimental research><experimental study><experiments><extracellular><gain of function><genetic analysis><genetic risk factor><genome mutation><gitter cell><hippocampal><human old age (65+)><hyper-phosphorylated tau><hyperphosphorylated tau><in vivo><inherited factor><insight><knockin><knockin mice><loss of function><mRNA Stability><mesoglia><microglial cell><microgliocyte><microtubule bound tau><microtubule-bound tau><model of animal><mouse model><murine model><necropsy><nerve cement><neural inflammation><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuroinflammation><neuroinflammatory><neuronal><neuropathologic tau><neuropathological tau><neuropsychiatric disease><neuropsychiatric disorder><noncoding><novel><over 65 years><pS2><perivascular glial cell><postmortem><presenilin><primary degenerative dementia><programs><protein synthesis><quantitative imaging><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social role><soluble amyloid precursor protein><synapse><synapse function><synaptic function><tangle><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic RNA><therapeutic agent development><therapeutic development><translation><τ Proteins><≥65 years>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

C. Neill EPPERSON

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 34/100
Training-friendly
Active award
$205,283
FY 2026

Project Title

Pathways for Physician Scientist Training in Psychiatric Research

Grant Number:

5R25MH125758-05

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2021

End Date:

10/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Abstract Physician-scientists serve a critical role in helping bridge the gap between basic and translational research and as noted in PAR-20-094 “bring a unique perspective to research through [a] blend of clinical and research experiences.” Thus training Psychiatrists for future careers as physici...

Research Terms

<0-11 years old><ABC20><ABCB1><ABCB1 gene><Address><Annual Reports><Applications Grants><Appointment><Area><Attention><Award><Basic Research><Basic Science><Biometrics><Biometry><Biostatistics><Board Certification><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Career Choice><Career Path><Child><Child Youth><Children (0-21)><Clinical><Clinical Research><Clinical Study><Colorado><Data><Data Collection><Dedications><Diagnosis><Drug Therapy><EXTMR><Economic Burden><Educational workshop><Epidemiology><Ethics><Extramural><Extramural Activities><Faculty><Feedback><Fellowship><Fostering><Funding><Future><GP170><Generalized Growth><Genetic><Goals><Grant><Grant Proposals><Growth><Institution><Internships><Investigators><Knowledge><MDR-1><MDR1><MDR1 Protein><Manuscripts><Mental disorders><Mental health disorders><Mentors><Mentorship><Mission><Monitor><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><NIH><NIMH><NRSA><National Institute of Mental Health><National Institutes of Health><National Research Service Awards><Neurosciences><Operations Research><Oral><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PGY-1 Protein><PGY1><Participant><Pathway interactions><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pharmacological Treatment><Pharmacotherapy><Physician's Role><Physicians><Position><Positioning Attribute><Post Graduate Year><Postdoc><Postdoctoral Fellow><Prevention><Productivity><Progress Reports><Psychiatric Disease><Psychiatric Disorder><Psychiatrist><Psychiatry><Psychotherapy><Public Health><Qualifying><Reproducibility><Research><Research Associate><Research Design><Research Methodology><Research Methods><Research Personnel><Research Support><Research Training><Researchers><Residencies><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Salaries><Scientific Inquiry><Scientist><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Structure><Study Type><Substance Use Disorder><Survey Instrument><Surveys><Time><Tissue Growth><Training><Translating><Translational Research><Translational Science><Translations><United States National Institutes of Health><Universities><Wages><Workshop><Writing><academic preparation><academic readiness><burden of disease><burden of illness><care for patients><care of patients><career><career aspiration><career interest><career pathway><career preparation><career readiness><career track><caring for patients><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cost><disease burden><drug intervention><drug treatment><effective therapy><effective treatment><epidemiologic><epidemiological><ethical><experience><faculty mentor><graduate school><improved><innovate><innovation><innovative><instructor><interest><intern><investigate longitudinal><job readiness><kids><life-long learning><lifelong learning><longitudinal investigation><longitudinal research><medical college><medical schools><mental illness><neural imaging><neuro-imaging><neuroimaging><neurological imaging><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><pathway><patient oriented outcomes><peer><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><posters><professor><programs><psychiatric illness><psychological disorder><recruit><research and methods><research associates><research faculty><response><responsible research conduct><school of medicine><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skill acquisition><skill development><social role><study design><study longitudinal><substance use and disorder><survey longitudinal><translation><translation research><translational investigation><work readiness><workforce readiness><workplace readiness><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Susan Kay Mikulich-Gilbertson

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 34/100
Training-friendly
Active award
$205,283
FY 2026

Project Title

Pathways for Physician Scientist Training in Psychiatric Research

Grant Number:

5R25MH125758-05

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2021

End Date:

10/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Abstract Physician-scientists serve a critical role in helping bridge the gap between basic and translational research and as noted in PAR-20-094 “bring a unique perspective to research through [a] blend of clinical and research experiences.” Thus training Psychiatrists for future careers as physici...

Research Terms

<0-11 years old><ABC20><ABCB1><ABCB1 gene><Address><Annual Reports><Applications Grants><Appointment><Area><Attention><Award><Basic Research><Basic Science><Biometrics><Biometry><Biostatistics><Board Certification><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Career Choice><Career Path><Child><Child Youth><Children (0-21)><Clinical><Clinical Research><Clinical Study><Colorado><Data><Data Collection><Dedications><Diagnosis><Drug Therapy><EXTMR><Economic Burden><Educational workshop><Epidemiology><Ethics><Extramural><Extramural Activities><Faculty><Feedback><Fellowship><Fostering><Funding><Future><GP170><Generalized Growth><Genetic><Goals><Grant><Grant Proposals><Growth><Institution><Internships><Investigators><Knowledge><MDR-1><MDR1><MDR1 Protein><Manuscripts><Mental disorders><Mental health disorders><Mentors><Mentorship><Mission><Monitor><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><NIH><NIMH><NRSA><National Institute of Mental Health><National Institutes of Health><National Research Service Awards><Neurosciences><Operations Research><Oral><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PGY-1 Protein><PGY1><Participant><Pathway interactions><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pharmacological Treatment><Pharmacotherapy><Physician's Role><Physicians><Position><Positioning Attribute><Post Graduate Year><Postdoc><Postdoctoral Fellow><Prevention><Productivity><Progress Reports><Psychiatric Disease><Psychiatric Disorder><Psychiatrist><Psychiatry><Psychotherapy><Public Health><Qualifying><Reproducibility><Research><Research Associate><Research Design><Research Methodology><Research Methods><Research Personnel><Research Support><Research Training><Researchers><Residencies><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Salaries><Scientific Inquiry><Scientist><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Structure><Study Type><Substance Use Disorder><Survey Instrument><Surveys><Time><Tissue Growth><Training><Translating><Translational Research><Translational Science><Translations><United States National Institutes of Health><Universities><Wages><Workshop><Writing><academic preparation><academic readiness><burden of disease><burden of illness><care for patients><care of patients><career><career aspiration><career interest><career pathway><career preparation><career readiness><career track><caring for patients><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cost><disease burden><drug intervention><drug treatment><effective therapy><effective treatment><epidemiologic><epidemiological><ethical><experience><faculty mentor><graduate school><improved><innovate><innovation><innovative><instructor><interest><intern><investigate longitudinal><job readiness><kids><life-long learning><lifelong learning><longitudinal investigation><longitudinal research><medical college><medical schools><mental illness><neural imaging><neuro-imaging><neuroimaging><neurological imaging><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><pathway><patient oriented outcomes><peer><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><posters><professor><programs><psychiatric illness><psychological disorder><recruit><research and methods><research associates><research faculty><response><responsible research conduct><school of medicine><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skill acquisition><skill development><social role><study design><study longitudinal><substance use and disorder><survey longitudinal><translation><translation research><translational investigation><work readiness><workforce readiness><workplace readiness><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JOSEPH T SAKAI

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 34/100
Training-friendly
Active award
$205,283
FY 2026

Project Title

Pathways for Physician Scientist Training in Psychiatric Research

Grant Number:

5R25MH125758-05

Activity Code:

R25

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/1/2021

End Date:

10/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Abstract Physician-scientists serve a critical role in helping bridge the gap between basic and translational research and as noted in PAR-20-094 “bring a unique perspective to research through [a] blend of clinical and research experiences.” Thus training Psychiatrists for future careers as physici...

Research Terms

<0-11 years old><ABC20><ABCB1><ABCB1 gene><Address><Annual Reports><Applications Grants><Appointment><Area><Attention><Award><Basic Research><Basic Science><Biometrics><Biometry><Biostatistics><Board Certification><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Career Choice><Career Path><Child><Child Youth><Children (0-21)><Clinical><Clinical Research><Clinical Study><Colorado><Data><Data Collection><Dedications><Diagnosis><Drug Therapy><EXTMR><Economic Burden><Educational workshop><Epidemiology><Ethics><Extramural><Extramural Activities><Faculty><Feedback><Fellowship><Fostering><Funding><Future><GP170><Generalized Growth><Genetic><Goals><Grant><Grant Proposals><Growth><Institution><Internships><Investigators><Knowledge><MDR-1><MDR1><MDR1 Protein><Manuscripts><Mental disorders><Mental health disorders><Mentors><Mentorship><Mission><Monitor><Multidrug Resistance 1><Multidrug Resistance Gene-1><Multidrug Resistance Gene-1s><Multidrug Resistance Proteins><Multidrug Resistant Proteins><NIH><NIMH><NRSA><National Institute of Mental Health><National Institutes of Health><National Research Service Awards><Neurosciences><Operations Research><Oral><P-GP><P-Glycoprotein><P-Glycoprotein 1 Gene><PGY-1 Protein><PGY1><Participant><Pathway interactions><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pharmacological Treatment><Pharmacotherapy><Physician's Role><Physicians><Position><Positioning Attribute><Post Graduate Year><Postdoc><Postdoctoral Fellow><Prevention><Productivity><Progress Reports><Psychiatric Disease><Psychiatric Disorder><Psychiatrist><Psychiatry><Psychotherapy><Public Health><Qualifying><Reproducibility><Research><Research Associate><Research Design><Research Methodology><Research Methods><Research Personnel><Research Support><Research Training><Researchers><Residencies><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Salaries><Scientific Inquiry><Scientist><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Structure><Study Type><Substance Use Disorder><Survey Instrument><Surveys><Time><Tissue Growth><Training><Translating><Translational Research><Translational Science><Translations><United States National Institutes of Health><Universities><Wages><Workshop><Writing><academic preparation><academic readiness><burden of disease><burden of illness><care for patients><care of patients><career><career aspiration><career interest><career pathway><career preparation><career readiness><career track><caring for patients><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cost><disease burden><drug intervention><drug treatment><effective therapy><effective treatment><epidemiologic><epidemiological><ethical><experience><faculty mentor><graduate school><improved><innovate><innovation><innovative><instructor><interest><intern><investigate longitudinal><job readiness><kids><life-long learning><lifelong learning><longitudinal investigation><longitudinal research><medical college><medical schools><mental illness><neural imaging><neuro-imaging><neuroimaging><neurological imaging><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><ontogeny><pathway><patient oriented outcomes><peer><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><post-doc><post-doctoral><post-doctoral trainee><post-doctoral training><posters><professor><programs><psychiatric illness><psychological disorder><recruit><research and methods><research associates><research faculty><response><responsible research conduct><school of medicine><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skill acquisition><skill development><social role><study design><study longitudinal><substance use and disorder><survey longitudinal><translation><translation research><translational investigation><work readiness><workforce readiness><workplace readiness><youngster>
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Matthew Lee Bush

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Exploratory lead · 32/100
Solid budget
Recent
Active award
$473,067
FY 2026

Project Title

Hearing Healthcare Assessment in Rural Communities (HHARC)

Grant Number:

5R33DC019602-05

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/4/2021

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY Hearing loss in adults is the third most common chronic health condition in the United States with a prevalence of over 20% in younger adults and over 40% in older adults. Untreated hearing loss causes a measurable impact on health and social, occupational, and emotional well-being o...

Research Terms

<21+ years old><Access to Care><Address><Administrator><Adult><Adult Human><Advisory Committees><Affect><Appalachia><Appalachian><Appalachian Region><Area><Audiogram><Audiometric Test><Audiometry><Certification><Chronic><Communication Disorders><Communication impairment><Communicative Disorders><Communities><Community Health><Community Health Care><Country><County><Depressed mood><Development><Diagnosis><Diagnostic><Disease><Disorder><Education><Educational aspects><Emotional well being><Employment><Enabling Factors><Enrollment><Environmental Factor><Environmental Risk Factor><Epidemiology><Evaluation><Face><Feels well><Geographic state><Goals><Health><Health Care><Health Care Providers><Health Care Systems><Health Care Utilization><Health Personnel><Health Services Accessibility><Health care promotion><Hearing><Hearing Loss><Hearing Tests><Hypoacuses><Hypoacusis><Intervention><Kentucky><Life><Measurable><Medical><Medical Economics><Methods><Morbidity><Normal mental condition><Normal mental state><Normal psyche><Occupational><Outcome><Patients><Phase><Population><Position><Positioning Attribute><Precede-Proceed Model><Predisposing Factor><Prevalence><Prevention><Primary Care><Protocol><Protocols documentation><Provider><Psychological Well Being><Public Health><Reinforcing Factor><Research><Research Resources><Resources><Rural><Rural Appalachia><Rural Appalachian><Rural Community><Sense of well-being><Specialty><Task Forces><United States><Vulnerable Populations><Well in self><access to health care><access to health services><access to services><access to treatment><accessibility of health care><accessibility to health care><accessibility to health services><adult youth><adulthood><advisory team><auditory tests><availability of services><barrier to care><barrier to health care><barrier to treatment><care access><care delivery><care resources><care utilization><community advisory board><community advisory committee><community advisory panel><community care><community-based health><compare treatment><depressed><develop therapy><developmental><dysfunctional hearing><emotional wellbeing><emotional wellness><enroll><environmental risk><epidemiologic><epidemiological><experience><faces><facial><health and care delivery><health assessment><health care access><health care availability><health care delivery><health care personnel><health care resources><health care service><health care service access><health care service availability><health care service use><health care service utilization><health care worker><health delivery systems><health provider><health service access><health services availability><health services delivery><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><hearing assessment><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><hearing loss therapy><hearing loss treatment><improved><innovate><innovation><innovative><intervention development><medical care providers><medical personnel><medical specialties><medically under served><medically underserved><mental well-being><mental wellbeing><mental wellness><mortality><novel><obstacle to care><obstacle to health care><older adult><older adulthood><patient navigation><pilot test><practice-based research network><preference><prevent><preventing><primary care practice><primary care services><programs><psychological wellbeing><psychological wellness><rural area><rural clinic><rural health care><rural health clinic><rural location><rural patients><rural region><rural under served><rural underserved><sadness><screening><screenings><self wellness><sense of wellbeing><service availability><social><therapy development><treatment access><treatment comparison><treatment development><treatment for hearing loss><treatment provider><under served community><underserved community><urban environment><urban setting><virtual><vulnerable group><vulnerable individual><vulnerable people><young adult><young adult age><young adulthood>
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Ardesheer Talati

NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NEW YORK, NY

Exploratory lead · 32/100
Solid budget
Recent
Active award
$467,368
FY 2026

Project Title

Gestational serotonin levels and offspring neurodevelopment

Grant Number:

1R21MH134530-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Project Abstract

PROJECT SUMMARY Serotonin is an important growth factor during gestation. Animal studies have shown that in early gestation, before the fetus’ own ability to synthesize serotonin develops, the mother’s serotonin system plays an important role in the fetus’ brain development in ways that impact futur...

Research Terms

<0-11 years old><0-4 weeks old><2nd trimester><5-HT><5-HT Agonists><5-HT pathway><5-HT system><5-Hydroxytryptamine><5-Hydroxytryptamine Agonists><5-Hydroxytrytamine Agonist><5HT><ASD><Active Follow-up><Address><Age><Age Months><Animal Model><Animal Models and Related Studies><Animals><Assay><Autism><Autistic Disorder><Behavior><Behavior assessment><Behavioral><Behavioral inhibition><Bioassay><Biological Assay><Birth><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Brain><Brain Nervous System><Brain imaging><Cell Communication and Signaling><Cell Signaling><Cells Placenta-Tissue><Child><Child Youth><Childhood><Children (0-21)><Clinical><Cognition><Cognitive><Cord Blood><Data><Data Analyses><Data Analysis><Data Collection><Data Element><Development><Diet><Drug Therapy><Early Infantile Autism><Embryo><Embryonic><Encephalon><Enteramine><Environment><Exploratory/Developmental Grant><Fetus><Fore-Brain><Forebrain><Funding><Future><Gene Expression><General Population><General Public><Gestation><Growth Agents><Growth Factor><Growth Substances><Hippophaine><Human><Infant><Infantile Autism><Infrastructure><Intervention><Intracellular Communication and Signaling><Kanner's Syndrome><Life><Literature><Measures><Mediating><Mice><Mice Mammals><Midtrimester><Modeling><Modern Man><Mothers><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocognitive><Neurocyte><Neurons><Newborn Infant><Newborns><Normal Placentoma><Outcome><Parents><Parturition><Pathway interactions><Pharmacological Treatment><Pharmacotherapy><Placenta><Placenta Embryonic Tissue><Placentome><Play><Population><Preclinical data><Prefrontal Cortex><Pregnancy><Prevention><Prosencephalon><Prospective Studies><Proteins Growth Factors><Psychopathology><R21 Mechanism><R21 Program><Role><Sampling><Second Pregnancy Trimester><Second Trimester><Serotonergic Agonists><Serotonergic System><Serotonin><Serotonin Agonists><Serotonin Receptor Agonists><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Snails><Social Development><Social Functioning><Somatosensory Cortex><Source><Symptoms><Testing><Thalamic structure><Thalamus><Thick><Thickness><Time><Umbilical Cord Blood><Whole Blood><Work><abnormal psychology><active followup><ages><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior outcome><behavioral assessment><behavioral outcome><biological signal transduction><brain visualization><cognitive assessment><cognitive development><cognitive testing><cohort><cost><cost effective><data interpretation><developmental><diets><drug intervention><drug treatment><early in pregnancy><early pregnancies><early pregnancy><early stage of pregnancy><exploratory developmental study><fetal><fetal cord blood><follow up><follow-up><followed up><followup><function socially><functioning social><global gene expression><global transcription profile><human study><innovate><innovation><innovative><kids><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><model of animal><multi-modality><multimodality><neural imaging><neuro-imaging><neurodevelopment><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological imaging><neuronal><neurotrophic factor><neurotrophin><neutrophin><newborn child><newborn children><offspring><parent><pathway><pediatric><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><postnatal><preclinical findings><preclinical information><premature><prematurity><prenatal><prospective><prospective research study><prospective survey><screening><screenings><sensory cortex><serotonergic pathway><serotonin pathway><serotonin system><sex><social><social role><somesthetic sensory cortex><thalamic><transcriptome><unborn><youngster>
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Jeremy Veenstra-VanderWeele

NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NEW YORK, NY

Exploratory lead · 32/100
Solid budget
Recent
Active award
$467,368
FY 2026

Project Title

Gestational serotonin levels and offspring neurodevelopment

Grant Number:

1R21MH134530-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Project Abstract

PROJECT SUMMARY Serotonin is an important growth factor during gestation. Animal studies have shown that in early gestation, before the fetus’ own ability to synthesize serotonin develops, the mother’s serotonin system plays an important role in the fetus’ brain development in ways that impact futur...

Research Terms

<0-11 years old><0-4 weeks old><2nd trimester><5-HT><5-HT Agonists><5-HT pathway><5-HT system><5-Hydroxytryptamine><5-Hydroxytryptamine Agonists><5-Hydroxytrytamine Agonist><5HT><ASD><Active Follow-up><Address><Age><Age Months><Animal Model><Animal Models and Related Studies><Animals><Assay><Autism><Autistic Disorder><Behavior><Behavior assessment><Behavioral><Behavioral inhibition><Bioassay><Biological Assay><Birth><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Brain><Brain Nervous System><Brain imaging><Cell Communication and Signaling><Cell Signaling><Cells Placenta-Tissue><Child><Child Youth><Childhood><Children (0-21)><Clinical><Cognition><Cognitive><Cord Blood><Data><Data Analyses><Data Analysis><Data Collection><Data Element><Development><Diet><Drug Therapy><Early Infantile Autism><Embryo><Embryonic><Encephalon><Enteramine><Environment><Exploratory/Developmental Grant><Fetus><Fore-Brain><Forebrain><Funding><Future><Gene Expression><General Population><General Public><Gestation><Growth Agents><Growth Factor><Growth Substances><Hippophaine><Human><Infant><Infantile Autism><Infrastructure><Intervention><Intracellular Communication and Signaling><Kanner's Syndrome><Life><Literature><Measures><Mediating><Mice><Mice Mammals><Midtrimester><Modeling><Modern Man><Mothers><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neural Development><Neurocognitive><Neurocyte><Neurons><Newborn Infant><Newborns><Normal Placentoma><Outcome><Parents><Parturition><Pathway interactions><Pharmacological Treatment><Pharmacotherapy><Placenta><Placenta Embryonic Tissue><Placentome><Play><Population><Preclinical data><Prefrontal Cortex><Pregnancy><Prevention><Prosencephalon><Prospective Studies><Proteins Growth Factors><Psychopathology><R21 Mechanism><R21 Program><Role><Sampling><Second Pregnancy Trimester><Second Trimester><Serotonergic Agonists><Serotonergic System><Serotonin><Serotonin Agonists><Serotonin Receptor Agonists><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Snails><Social Development><Social Functioning><Somatosensory Cortex><Source><Symptoms><Testing><Thalamic structure><Thalamus><Thick><Thickness><Time><Umbilical Cord Blood><Whole Blood><Work><abnormal psychology><active followup><ages><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><behavior outcome><behavioral assessment><behavioral outcome><biological signal transduction><brain visualization><cognitive assessment><cognitive development><cognitive testing><cohort><cost><cost effective><data interpretation><developmental><diets><drug intervention><drug treatment><early in pregnancy><early pregnancies><early pregnancy><early stage of pregnancy><exploratory developmental study><fetal><fetal cord blood><follow up><follow-up><followed up><followup><function socially><functioning social><global gene expression><global transcription profile><human study><innovate><innovation><innovative><kids><microbiome intervention><microbiome therapeutics><microbiome therapy><microbiome treatment><microbiome-based intervention><microbiome-based therapeutic><microbiome-based therapy><microbiome-based treatment><model of animal><multi-modality><multimodality><neural imaging><neuro-imaging><neurodevelopment><neuroimaging><neuroimaging biomarker><neuroimaging marker><neurological imaging><neuronal><neurotrophic factor><neurotrophin><neutrophin><newborn child><newborn children><offspring><parent><pathway><pediatric><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><postnatal><preclinical findings><preclinical information><premature><prematurity><prenatal><prospective><prospective research study><prospective survey><screening><screenings><sensory cortex><serotonergic pathway><serotonin pathway><serotonin system><sex><social><social role><somesthetic sensory cortex><thalamic><transcriptome><unborn><youngster>
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Kimberly Elizabeth Beatty

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Exploratory lead · 32/100
Solid budget
Recent
Active award
$442,758
FY 2026

Project Title

Identifying drug targets in M. abscessus through the application of fluorescent probes

Grant Number:

1R21AI196663-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/9/2026

End Date:

1/31/2028

Project Abstract

Project Summary In the United States, a person is more likely to be infected by a non-tuberculous mycobacteria (NTM) than Mycobacterium tuberculosis (Mtb). Most NTM pulmonary infections are caused by one of two species: Mycobacterium avium or Mycobacterium abscessus (Mab). Of the two, infections wit...

Research Terms

<Acceleration><Acute><Affect><Anabolism><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Assay><B subtilis><B. subtilis><Bacillus subtilis><Bacteria><Bacterial Infections><Bioassay><Biological Assay><Biology><Bronchiectasis><Case Study><Case-Base Studies><Cell Wall><Chemicals><Chronic><Clinical><Clinical Management><Clinical Trials Design><Complement><Complement Proteins><Cy5><Cystic Fibrosis><Data><Death Rate><Development><Disease><Disorder><Drug Targeting><Drug resistance><Drugs><E coli><E. coli><Educational process of instructing><Ensure><Enzyme Gene><Enzyme Inhibition><Enzymes><Escherichia coli><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fluorescent Probes><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><G24 protein><Gel><Genus Mycobacterium><Goals><Guidelines><Infection><Knowledge><Label><Lead><Left><Logic><Lung><Lung Diseases><Lung Respiratory System><Lung infections><M abscessus><M avium><M tb><M tuberculosis><M. abscessus><M. avium><M. tb><M. tuberculosis><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Medication><Mice><Mice Mammals><Miscellaneous Antibiotic><Mucoviscidosis><Murine><Mus><Mycobacterial Infection><Mycobacterium><Mycobacterium Infections><Mycobacterium abscessus><Mycobacterium avium><Mycobacterium tuberculosis><Mycobacteroides abscessus><NIAID><National Institute of Allergy and Infectious Disease><Patients><Pattern><Pb element><Penicillin-Binding Proteins><Peptidyl Transferases><Peptidyl Translocases><Peptidyltransferase><Persons><Pharmaceutical Preparations><Predisposition><Proteins><Proteomics><Pulmonary Diseases><Pulmonary Disorder><Regimen><Regulation><Research><Resistance><Scheme><Survey Instrument><Surveys><Susceptibility><Teaching><Testing><Transpeptidases><Treatment Protocols><Treatment Regimen><Treatment Schedule><United States><Update><Work><bacteria infection><bacteria pathogen><bacterial disease><bacterial pathogen><beta lactam antibiotic><beta lactam hydrolase><beta-Lactamase><beta-Lactamhydrolase><beta-Lactams><biosynthesis><case report><clinical relevance><clinically relevant><complementation><crosslink><cyanine dye 5><design><designing><developmental><disease of the lung><disorder of the lung><drug resistant><drug/agent><heavy metal Pb><heavy metal lead><improved><innovate><innovation><innovative><insight><lung disorder><medical countermeasure><model organism><mortality rate><mouse model><mtb><murine model><mycobacterial><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><non-tuberculosis mycobacteria><non-tuberculosis mycobacterial><non-tuberculous mycobacteria><non-tuberculous mycobacterial><nontuberculosis mycobacterial><nontuberculous mycobacteria><nontuberculous mycobacterial><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pathogen><pathogenic bacteria><pulmonary><pulmonary infections><resistance to Drug><resistant><resistant to Drug><response><synergism><therapeutically effective><β lactam antibiotic><β-Lactamase><β-Lactams>
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William Ellerbe Pelham III

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 32/100
Solid budget
Recent
Active award
$439,500
FY 2026

Project Title

An episode-based paradigm for studying family dynamics in adolescent substance use

Grant Number:

1R21DA062923-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/29/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT Family processes such as parental monitoring of the teens’ whereabouts or provision of discipline are core treatment targets in our most potent clinical interventions to reduce or prevent adolescent substance use, but we know relatively little about how family processes driv...

Research Terms

<Alcohol Drinking><Alcohol consumption><Attention><Basic Research><Basic Science><Behavior><Behavior monitoring><Child Rearing><Clinical><Clinical Treatment><Communication><Data><Data Collection><Development><Discipline><Divorce><Divorced state><Drug usage><Educational process of instructing><Emotional><EtOH drinking><EtOH use><Family><Family Process><Family Research><Family dynamics><Frequencies><Future><Home><Interview><Lead><Link><Measurement><Measures><Monitor><Outcome><Outcomes Research><Parenting><Parenting behavior><Parents><Pattern><Pb element><Protocol><Protocols documentation><Reaction><Recommendation><Reporting><Research><Response to stimulus physiology><Risk Reduction><Role><Schedule><Schools><Structure><Survey Instrument><Surveys><Teaching><Teen><Teenagers><Testing><Time><Translations><Validation><Youth><Youth 10-21><adolescent substance use><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><behavior response><behavioral monitoring><behavioral response><childrearing><clinical intervention><clinical therapy><developmental><drinking><drug use><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><family based research><family centered research><family focused research><family investigation><family structure/dynamics><heavy metal Pb><heavy metal lead><homes><insight><investigate family><large scale data><large scale data sets><large scale datasets><novel><parent><parent monitoring><parental monitoring><prevent><preventing><programs><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><response><risk-reducing><social role><stimulus/response><study family><substance use><substance use among adolescents><substance use among youth><substance using><survey family><teen years><teenage><translation><trial regimen><trial treatment><usability><validations><youth age><youth substance use>
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David J Gonzalez

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 32/100
Solid budget
Recent
Active award
$439,375
FY 2026

Project Title

Development and validation of S protein as a group A streptococcus vaccine

Grant Number:

1R21AI191616-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/20/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Group A Streptococcus (GAS) is among the most common infectious agents worldwide, with an estimated 700 million infections and half-million deaths per year, numbers that increase annually. These factors, in addition to the growing prevalence of antimicrobial-resistant strains, it is ...

Research Terms

<Address><Adjuvant><Alum Adjuvant><Amino Acid Sequence><Amino Acids><Animal Model><Animal Models and Related Studies><Animals><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Antibodies><Antigens><Antimicrobial Resistance><Area><Autoimmune Status><Autoimmunity><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Bacteria><Binding><Blood Serum><Blood erythrocyte><Cessation of life><Clinical><Colony-forming units><Cross Reactions><Data><Data Set><Death><Development><Drug Kinetics><Erythrocytes><Erythrocytic><Evaluation><Goals><Health><Human><Immune><Immune Evasion><Immune response><Immunes><Immunity><Immunization><Immunize><In Vitro><Infection><Infectious Agent><Infectious Skin Diseases><Intramuscular><Investigation><Investigators><M protein><Macaca><Macaque><Marketing><Marrow erythrocyte><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular Interaction><Molecular Mimicry><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><NIH><Nasopharynx><National Institutes of Health><Outcome><Passive Immunization><Pathogenesis><Pathogenicity Factors><Penicillins><Phagocytes><Phagocytic Cell><Pharmacokinetics><Position><Positioning Attribute><Pre-Clinical Model><Preclinical Models><Preclinical data><Predisposition><Prevalence><Prevention><Primary Protein Structure><Property><Proteins><Proteomics><Protocol><Protocols documentation><Publishing><Recombinant Proteins><Red Blood Cells><Red Cell><Research Personnel><Researchers><Resistance><Rhinopharynx><Risk><Route><S. pyogenes><Serotyping><Serum><Site><Streptococcal Infections><Streptococcal Vaccines><Streptococcus Group A><Streptococcus infection><Streptococcus pyogenes><Surface><Susceptibility><Systemic infection><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-cell therapeutics><T-cell transfer therapy><Techniques><Translating><United States National Institutes of Health><Universal Coverage><Vaccine Antigen><Vaccines><Validation><Virulence><Virulence Factors><Work><access to vaccination><access to vaccines><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><alum><aluminum sulfate><amebocyte><aminoacid><anti-microbial resistant><bacteria pathogen><bacterial pathogen><beta lactam antibiotic><beta-Lactams><blood corpuscles><clinical relevance><clinically relevant><cohort><cross reactivity><cutaneous infection><develop a vaccine><develop vaccines><development of a vaccine><developmental><experiment><experimental research><experimental study><experiments><group A strep><host response><human pathogen><immune evasive><immune system response><immunogen><immunogenicity><immunoresponse><improved><in vivo><incomplete Freund's adjuvant><infected skin><infectious organism><innovate><innovation><innovative><insight><instrument><model of animal><mouse model><multiple myeloma M Protein><murine model><nasopharnygeal><new vaccines><next generation vaccines><novel><novel vaccines><particle><passive vaccination><pathogenic bacteria><preclinical findings><preclinical information><protein purification><protein sequence><resistance strain><resistance to anti-microbial><resistant><resistant strain><resistant to antimicrobial><skin infection><subcutaneous><subdermal><therapeutic T-cell platform><universal vaccine><vaccination access><vaccination availability><vaccination study><vaccination trial><vaccine access><vaccine availability><vaccine candidate><vaccine development><vaccine study><vaccine trial><vaccinology><validations><β lactam antibiotic><β-Lactams>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Nicole Franziska Steinmetz

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 32/100
Solid budget
Recent
Active award
$420,505
FY 2026

Project Title

Understanding plant virus-based adjuvants as therapeutics

Grant Number:

1R21CA309173-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Project Abstract

This application is focused on the study of bioengineered plant virus-based adjuvant and vaccine technology. We discovered that some plant viruses serve as potent adjuvants in the context of infectious disease and cancer vaccines/immunotherapy. Cowpea mosaic virus (CPMV) was identified as a uniquely...

Research Terms

<(TNF)-α><ATAC sequencing><ATAC-seq><ATACseq><Adjuvant><Agonist><Antigens><Antineoplastic Vaccine><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Autoregulation><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B16F10><BCDF><BSF-2><BSF2><Benchmarking><Best Practice Analysis><Beta Proprotein Interleukin 1><Bioassay><Biodistribution><Biological Assay><Biomedical Engineering><Blood Precursor Cell><Blood monocyte><Cachectin><Cancer Model><Cancer Patient><Cancer Treatment><Cancer Vaccines><CancerModel><Cancers><Canine Species><Canis familiaris><Cell Body><Cells><ChIP Sequencing><ChIP-seq><ChIPseq><Chromatin Structure><Clinical><Communicable Diseases><Cowpea Mosaic Viruses><Data><Development><Disease><Disorder><Disseminated Malignant Neoplasm><Dogs><Dogs Mammals><Effectiveness><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exhibits><Exploratory/Developmental Grant><Exposure to><Foundations><H1N1><H1N1 Virus><HPGF><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Hepatocyte-Stimulating Factor><Homeostasis><Human><Hybridoma Growth Factor><IFN><IFN-beta 2><IFNB2><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL-6><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><IL6 Protein><Immune><Immune Regulators><Immune mediated therapy><Immune memory><Immune response><Immune system><Immunes><Immunity><Immunologic Memory><Immunologic Stimulation><Immunological Memory><Immunological Stimulation><Immunologically Directed Therapy><Immunomodulation><Immunomodulators><Immunoprevention><Immunostimulation><Immunotherapy><In Vitro><Infectious Diseases><Infectious Disorder><Inflammatory><Influenza A Virus, H1N1 Subtype><Influenza Virus><Innate Immune System><Interferons><Interleukin 1beta><Interleukin-1 beta><Interleukin-1β><Interleukin-6><KO mice><Knock-out Mice><Knockout Mice><Longitudinal Studies><Longitudinal Surveys><MGI-2><Macrophage-Derived TNF><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mammalian Cell><Marrow monocyte><Measures><Memory><Metabolic><Metastatic Cancer><Metastatic Malignant Neoplasm><Mice><Mice Mammals><Modeling><Modern Man><Monocyte-Derived TNF><Multipotent Stem Cells><Murine><Mus><Myeloid Differentiation-Inducing Protein><Nature><Neoplasm Vaccines><Null Mouse><Oncolytic viruses><PBMC><Pathology><Pathway interactions><Peripheral Blood Mononuclear Cell><Physiological Homeostasis><Plant Viruses><Plants><Plasmacytoma Growth Factor><Preinterleukin 1 Beta><Property><R21 Mechanism><R21 Program><Reporting><Research><Research Proposals><Role><Safety><Signal Pathway><Single cell seq><Structure><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Technology><Testing><Therapeutic><Training><Tumor Immunity><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Tumor Vaccines><Vaccination><Vaccines><Virus><Work><anamnestic reaction><anti-cancer therapy><anti-tumor immunity><anti-tumor vaccine><antitumor immunity><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><benchmark><bio-engineered><bio-engineers><bioengineering><biological engineering><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cancer cell><cancer immunity><cancer therapy><cancer-directed therapy><canine><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><cowpea virus><cytokine><developmental><domestic dog><drug candidate><epigenetically><exploratory developmental study><flu infection><flu virus infection><food Ingestion><food consumption><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><host response><immune modulation><immune modulators><immune regulation><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunologic reactivity control><immunomodulatory><immunomodulatory molecules><immunoregulation><immunoregulator><immunoregulatory><immunoregulatory molecules><immunoresponse><infected with flu><infected with flu virus><infected with influenza><infected with influenza virus><influenza infection><influenza virus infection><influenzavirus><innovate><innovation><innovative><insight><interferon beta 2><live attenuated flu vaccine><live attenuated influenza vaccine><live attenuated influenza virus vaccine><long-term study><longitudinal outcome studies><longitudinal research study><malignancy><monocyte><mouse model><multipotent progenitor><multipotent progenitor cell><murine model><nano><neoplasm/cancer><novel><pathway><progenitor><recruit><secondary immune response><single cell next generation sequencing><single cell sequencing><small molecule><social role><tumor><tumor growth><vaccine for cancer><vaccine formulation><β-Glucans>
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Kevin S. McIver

UNIV OF MARYLAND, COLLEGE PARK, COLLEGE PARK, MD

Exploratory lead · 32/100
Solid budget
Recent
Active award
$417,295
FY 2026

Project Title

Regulation of Heme Adaptation in the Group A Streptococcus

Grant Number:

1R21AI196768-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/23/2026

End Date:

1/31/2028

Project Abstract

Project Summary The overarching goal of this R21 proposal is to define the mechanisms by which Group A Streptococcus (GAS) senses and adapts to changing heme levels encountered during invasive infections such as bacteremia. Heme is both a critical nutrient for GAS that is kept sequestered by hemopro...

Research Terms

<4-O-beta-D-galactopyranosyl-D-glucose><Active Oxygen><Acute Disease><Bacteremia><Binding><Biochemical><Blood><Blood Reticuloendothelial System><Body Tissues><Cell Communication and Signaling><Cell Signaling><Complex><Cues><D-Galactose><Development><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Dysfunction><Environment><Fe element><Ferroprotoporphyrin><Fructose><Functional disorder><Galactopyranose><Galactopyranoside><Galactose><Gene Expression><Gene Transcription><Generalized Growth><Genes><Genetic Transcription><Genetics-Mutagenesis><Goals><Group Processes><Growth><Heme><Heme Proteins><Hemeproteins><Hemolysis><Hemostasis><Hemostatic function><Human Figure><Human body><IgA><Immunoglobulin A><In Vitro><Infection><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><Iron><Kinases><Lactose><Levulose><Mediating><Metabolic><Metabolic Drug Detoxications><Metabolic Pathway><Metabolic Processes><Metabolism><Metabolism of Toxic Agents><Metals><Methods><Modality><Molecular><Molecular Genetics><Molecular Interaction><Monitor><Mutagenesis><Mutagenesis Molecular Biology><Nutrient><Nutritional><Nutritional Immunity><Operon><Oxygen Radicals><Pathogenesis><Pathogenicity Factors><Pathway interactions><Phosphotransferase Gene><Phosphotransferases><Physiopathology><Play><Prevention><Pro-Oxidants><Property><Proteins><Protoheme><Publishing><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Reactive Oxygen Species><Regulation><Regulatory Pathway><Regulatory Protein><Resistance><Role><S. pyogenes><Signal Transduction><Signal Transduction Systems><Signaling><Source><Streptococcal Infections><Streptococcus Group A><Streptococcus infection><Streptococcus pyogenes><Stress><System><Testing><Tissue Growth><Tissues><Tn-seq><Tnseq><Toxic effect><Toxicities><Transcription><Transphosphorylases><Virulence><Virulence Factors><access to vaccination><access to vaccines><acute disease/disorder><acute disorder><bacteraemia><bacterial bloodstream infection><bacterial infection in the bloodstream><biological signal transduction><blood infection><bloodstream infection><detoxification><developmental><erythrolysis><extracellular><ferroheme><fitness><genetic regulatory protein><genome scale><genome-wide><genomewide><global gene expression><global transcription profile><group A strep><heme a><hemoprotein><human pathogen><in vivo><in vivo Model><infection in the blood><infection of the blood><insight><lipophilicity><new approaches><novel><novel approaches><novel strategies><novel strategy><nutritious><ontogeny><pathogen><pathophysiology><pathway><programs><regulatory gene product><repair><repaired><resistant><response><sensor><social group process><social role><sugar><transcriptome><transcriptome sequencing><transcriptomic sequencing><transposon insertion sequencing><transposon sequencing><vaccination access><vaccination availability><vaccine access><vaccine availability>
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Hongbing Wang

MICHIGAN STATE UNIVERSITY, EAST LANSING, MI

Exploratory lead · 32/100
Solid budget
Recent
Active award
$416,859
FY 2026

Project Title

Probing nucleolus function in a mouse model of fragile X syndrome

Grant Number:

1R21MH140167-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/3/2026

End Date:

2/29/2028

Project Abstract

Project Summary Fragile X syndrome (FXS) stands as a prominent contributor to intellectual disability and autism spectrum disorders, stemming from mutations within the FMR1 gene. These mutations lead to severe reduction or absence of the FMRP protein. Despite extensive research, effective medical in...

Research Terms

<ASD><Animal Model><Animal Models and Related Studies><Astrocytes><Astrocytus><Astroglia><Autism><Autistic Disorder><Automobile Driving><B23><Basic Research><Basic Science><Biochemical><Biogenesis><Biological Markers><Blood><Blood Cells><Blood Reticuloendothelial System><Body Tissues><CNS Nervous System><Cell Nucleolus><Central Nervous System><Clinical><Clinical Markers><DNA mutation><DNA-Dependent RNA Polymerase I><Data><Disease><Disorder><Drugs><Dysfunction><Early Infantile Autism><Escalante syndrome><Exhibits><Female><Fragile X><Fragile X Syndrome><Functional disorder><Gene Transcription><Genes><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Glia><Glial Cells><Heterogeneity><Human><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intelligence quotient><Intervention><Investigation><KO mice><Kanner's Syndrome><Knock-out Mice><Knockout Mice><Knowledge><Kolliker's reticulum><Lead><Link><Lymphatic cell><Lymphocyte><Lymphocytic><Martin-Bell Syndrome><Martin-Bell-Renpenning syndrome><Measures><Mediating><Medical><Medication><Messenger RNA><Methylation><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Mutation><NPM><NPM1><NPM1 gene><Nerve Cells><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Non-neuronal cell><Nonneuronal cell><Nucleolar Proteins><Null Mouse><Organelles><Origin of Life><Outcome><Pathologic><Pathology><Patients><Pb element><Peripheral><Peripheral Blood Cell><Pharmaceutical Preparations><Physiopathology><Plasmosome><Pre-rRNA><Protein Biosynthesis><Proteins><Proteomics><RNA Expression><RNA Polymerase A><RNA Polymerase I><RNA, Ribosomal, Precursors><Renpenning syndrome 2><Research><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Ribosomal RNA><Ribosomes><Role><Sampling><Tissues><Transcription><Translational Regulation><Translations><X-linked mental deficiency-megalotestes syndrome><X-linked mental retardation with fragile X syndrome><X-linked mental retardation-fragile site 1 syndrome><astrocytic glia><autism spectral disorder><autism spectrum disorder><autism-fragile X (AFRAX) syndrome><autistic spectrum disorder><bio-markers><biologic marker><biomarker><brain cell><cell type><cellular pathology><clinical biomarkers><clinically useful biomarkers><comparative><driving><drug/agent><excitatory neuron><fra(X) syndrome><fra(X)(28) syndrome><fra(X)(q27) syndrome><fra(X)(q27-28) syndrome><fragile X-mental retardation syndrome><fragile Xq syndrome><fragile site mental retardation 1><genome mutation><genome wide analysis><genome wide studies><genome-wide analysis><genome-wide identification><heavy metal Pb><heavy metal lead><inhibitory neuron><innovate><innovation><innovative><intellectual and developmental disability><limited intellectual functioning><lymph cell><mRNA><mRNA Translation><mRNP><macro-orchidism-marker X (MOMX) syndrome><macro-orchidism-marker X syndrome><male><mar(X) syndrome><marker X syndrome><mental retardation-macroorchidism syndrome><messenger ribonucleoprotein><model of animal><mouse model><murine model><nerve cement><neuronal><novel><nucleolus><pathophysiology><potential biological marker><potential biomarker><pre-clinical><preclinical><protein biomarkers><protein markers><protein synthesis><rRNA><rRNA Precursor><social role><stem><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic agent development><therapeutic development><translation><♀><♂>
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Alban Longchamp

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 32/100
Solid budget
Recent
Active award
$416,622
FY 2026

Project Title

Ex-Vivo Machine Perfusion To Promote Tolerance Induction in Deceased Donor Kidney Transplantation

Grant Number:

1R21AI196804-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/23/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Establishing a reliable method to achieve allograft tolerance remains an ultimate goal in organ transplantation. We previously reported long-term immunosuppression (I.S.)-free renal allograft survival in humans after induction of only transient hematopoietic chimerism through donor ...

Research Terms

<Acute><Address><Affect><Allograft Tolerance><Allografting><Antibodies><B cell lymphoma 2><B-Cell CLL/Lymphoma 2 Gene><B-cell lymphoma/leukemia-2><BCL2><BCL2 gene><Bcl-2><Biography><Biopsy><Blood monocyte><Bone Marrow Grafting><Bone Marrow Transplant><Bone Marrow Transplantation><CD11b><CD154><CD18><CD40L><CD40LG><CR3A><Calcineurin antagonist><Calcineurin inhibitor><Cell Body><Cells><Chimerism><Chronic><Clinical><Clinical Treatment Moab><Clinical Trials><Cryofixation><Cryopreservation><DNA Molecular Biology><Development><Devices><Donor person><Dose><Drugs><Engineering><Goals><Graft Survival><Grafting Procedure><Hematopoietic><Histologic><Histologically><Hour><Human><Hypothermia><ITGAM><ITGAM gene><ITGB2><ITGB2 gene><Immune><Immune Tolerance><Immunes><Immunologic Tolerance><Immunology><Immunosuppressants><Immunosuppression><Immunosuppression Effect><Immunosuppressive Agents><Immunosuppressive Effect><Immunosuppressive drug><Immunosuppressive treatment><Inflammatory><Injury><Innate Immune Response><Integrins><Integrins Extracellular Matrix><Ischemia><Ischemia-Reperfusion Injury><Kidney><Kidney Grafting><Kidney Transplantation><Kidney Transplants><Kidney Urinary System><LCAMB><Length><Lymphoproliferative Disorders><MAC1A><MF17><MO1A><Macrophage><Marrow Transplantation><Marrow monocyte><Medication><Metabolic><Methods><Modeling><Modern Man><Molecular><Molecular Biology><Monoclonal Antibodies><Mononuclear><Mφ><NHP models><Organ Preservation><Organ Transplantation><Organ Transplants><Outcome Study><Output><Perfusion><Phagocytes><Phagocytic Cell><Pharmaceutical Preparations><Protocol><Protocols documentation><Regimen><Renal Grafting><Renal Transplantation><Renal Transplants><Reperfusion Damage><Reperfusion Injury><Reporting><Research><Risk><Surface><Survival Rate><System><T-Cell Depletion><T-Cells><T-Lymphocyte><T-cell depletion therapy><T-lymphocyte depletion therapy><TNFSF5><TNFSF5 gene><TRAP Gene><Technology><Testing><Thymus><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Time><Total Body Irradiation><Transplantation><Transplantation Tolerance><Urine><Whole-Body Irradiation><Whole-Body Radiation><allotransplant><allotransplantation><amebocyte><bcl-2 Genes><ced9 homolog><clinical applicability><clinical application><clinical relevance><clinically relevant><cohort><cold preservation><cold storage><conditioning><deceased donor><deceased organ donors><design><designing><developmental><drug/agent><ex vivo perfusion><hemopoietic><immune suppression><immune suppressive activity><immune suppressive agent><immune suppressive function><immune suppressor><immune system tolerance><immune unresponsiveness><immunological paralysis><immunosuppressive activity><immunosuppressive function><immunosuppressive response><immunosuppressive substance><immunosuppressor><improved><injuries><irradiation><kidney allograft><kidney preservation><kidney tx><live kidney donor><living kidney donor><lymphoproliferative disease><mAbs><monoclonal Abs><monocyte><natural hypothermia><non-human primate><nonhuman primate><nonhuman primate models><organ allograft><organ graft><organ xenograft><post-transplant><post-transplantation><posthumous donors><posthumous organ donor><posttransplant><posttransplantation><preservation><primary outcome><renal><renal allograft><side effect><success><thymus derived lymphocyte><transcriptome profiling><transcriptomic profiling><transcriptomics><transplant><transplant donor><transplant model>
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STEVEN F DOWDY

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 32/100
Solid budget
Recent
Active award
$410,933
FY 2026

Project Title

Targeting Lethal mCRPC with siRNA Therapeutics

Grant Number:

1R21CA307811-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/18/2026

End Date:

2/29/2028

Project Abstract

ABSTRACT Metastatic Castration-Resistant Prostate Cancer (mCRPC) is an untreatable, lethal disease. mCRPC preferentially metastasizes to bone where it causes destructive and painful lesions in the patient. mCRPC tumor cell growth, survival and metastasis is driven by genetically mutated and altered ...

Research Terms

<AR gene><American male><American man><American men><Androgen Antagonists><Androgen Receptor><Androgenic Agents><Androgenic Compounds><Androgens><Anti-Androgen><Anti-Androgen Agents><Antigen Targeting><Assay><Avidity><Binding Proteins><Bioassay><Biodistribution><Biological Assay><Biophysics><Bone Metastasis><Bone cancer metastatic><Bony metastasis><Caliber><Cancer Genes><Cancer Induction><Cancer Patient><Cancer-Promoting Gene><Cell Death><Cell Survival><Cell Viability><Cellular Expansion><Cellular Growth><Cessation of life><Chemistry><Clinical><Clinical Trials><DNA mutation><Death><Development><Diagnosis><Dihydrotestosterone Receptor><Disease><Disorder><Dose><Drug Receptors><Drug resistance><Drugs><Early-Stage Clinical Trials><Endosomes><Experimental Therapies><FOLH><FOLH1><FOLH1 gene><Femur><Folate Hydrolase 1><GCP2><Generations><Genes><Genetic><Genetic Change><Genetic Medicine><Genetic defect><Genetic mutation><Glutamate Carboxypeptidase II><Goals><Grant><Hepatic Disorder><In Vitro><Innate Immune Response><Investigational Therapies><Investigational Treatments><Length of Life><Lesion><Ligand Binding Protein><Ligand Binding Protein Gene><Liver diseases><Location><Longevity><Luciferase Immunologic><Luciferases><Malignant neoplasm of prostate><Malignant prostatic tumor><Medication><Metabolic><Metastasis><Metastasis to bone><Metastasize><Metastatic Cancer to the Bone><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Bone><Metastatic Tumor><Metastatic Tumor to the Bone><Metastatic malignant neoplasm to bone><Mice><Mice Mammals><Murine><Mus><Mutate><Mutation><N-Acetylated Alpha-Linked Acidic Dipeptidase 1><NAALAD1><NAALADase I><NR3C4><Neoplasm Metastasis><Normal Cell><Oncogenes><Oncogenic><Osseous metastasis><PSM><PSMA><Pain><Painful><Patients><Pharmaceutical Preparations><Phase 1 Clinical Trials><Phase I Clinical Trials><Post-Transcriptional Gene Silencing><Property><Prostate><Prostate CA><Prostate Cancer><Prostate Gland><Prostate malignancy><Prostate-Specific Membrane Antigen><Prostatic Gland><Protein Binding><RNA Interference><RNA Silencing><RNAi><Receptosomes><Relapse><Reporter><Resistance><SMAX1><Sampling><Secondary Neoplasm><Secondary Tumor><Secondary cancer of bone><Secondary malignancy of bone><Secondary malignant neoplasm of bone><Sequence-Specific Posttranscriptional Gene Silencing><Short interfering RNA><Skeletal metastasis><Small Interfering RNA><Specificity><Technology><Testing><Therapeutic><Therapeutic Androgen><Transforming Genes><Tumor Burden><Tumor Cell><Tumor Load><U.S. Males><US Men><US male><Work><androgen ablation therapy><androgen blockade therapy><androgen deprivation therapy><androgen deprivation treatment><androgen independent prostate cancer><androgen indifferent prostate cancer><androgen inhibitor><androgen insensitive prostate cancer><androgen receptor gene><androgen resistance in prostate cancer><androgen resistant prostate cancer><antagonism><antagonist><biophysical foundation><biophysical principles><biophysical sciences><bone neoplasm secondary><bound protein><cancer metastasis><carcinogenesis><castration resistant CaP><castration resistant PCa><castration resistant prostate cancer><cell growth><clinical development><deliver short interfering RNA><deliver siRNA><deliver small interfering RNA><delivery system for siRNA><delivery system for small interfering RNA><delivery vectors for siRNA><design><designing><developmental><drug resistant><drug/agent><experimental therapeutic agents><experimental therapeutics><gene product><genome mutation><hepatic disease><hepatopathy><high risk><hormone refractory prostate cancer><in vivo><liver disorder><males in America><males in the U.S.><males in the US><males in the USA><males in the United States><men in America><men in the U.S.><men in the US><men in the USA><men in the United States><mouse model><murine model><necrocytosis><neoplastic cell><new drug treatments><new drugs><new pharmacological therapeutic><new technology><new therapeutics><new therapy><next generation><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel technologies><novel therapeutics><novel therapy><overexpress><overexpression><personalized genetics><phase I protocol><pre-clinical><pre-clinical development><precision genetics><preclinical><preclinical development><prostate cancer model><prostate cancer resistant to androgen><prostate tumor model><resistance mutation><resistance to Drug><resistant><resistant mutation><resistant to Drug><response><short interfering RNA delivery><siRNA><siRNA delivery><siRNA therapy><siRNA-based therapeutic><siRNA-based therapy><small interfering RNA delivery><small molecule><systemic toxicity><therapeutic siRNA><therapeutic small interfering RNA><tumor><tumor cell metastasis>
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STEPHEN C JAMESON

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 32/100
Solid budget
Recent
Active award
$407,326
FY 2026

Project Title

Differentiation and characteristics of Helios+ CD8+ T cells

Grant Number:

1R21AI196205-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/12/2026

End Date:

1/31/2028

Project Abstract

Summary Regulation of immune responses is critical to provide beneficial immunity against pathogens and cancer, while avoiding autoimmune diseases and immunopathology. A population of memory-phenotype CD8+ T cells, expressing the transcription factor Helios” has been proposed to play a key role in p...

Research Terms

<Ablation><Address><Affect><Autoimmune Diseases><Autoimmune Responses><Autoregulation><Basal Transcription Factor><Basal transcription factor genes><Biologic Models><Biological Models><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD94 Antigen><CRISPR><CRISPR/Cas system><Cancers><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Characteristics><Class I Antigens><Class I Major Histocompatibility Antigens><Clustered Regularly Interspaced Short Palindromic Repeats><Complex Class 1><Data><Development><Exploratory/Developmental Grant><Expression Signature><Family><Future><Gene Expression><Gene Expression Profile><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genetic Transcription><Histocompatibility Antigens Class I><Homeostasis><Human><Immune><Immune response><Immunes><Immunity><Immunomodulation><Infection><Inflammation><KLRD1 Protein><Killer Cell Lectin-Like Receptor Subfamily D, Member 1><Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Isoforms 1, 2><Killer Cell Lectin-Like Receptor Subfamily D, Member 1 Protein><Knowledge><Kp43 antigen><MHC Class I Molecule><MHC Class I Protein><MHC class I antigen><Maintenance><Major Histocompatibility Complex Class 1><Malignant Neoplasms><Malignant Tumor><Memory><Mice><Mice Mammals><Model System><Modeling><Modern Man><Murine><Mus><NK Cell Receptor><NK receptor><Natural Killer Cells Antigen CD94><Pathogenicity><Peripheral><Phenotype><Physiologic><Physiological><Physiological Homeostasis><Play><Population><Position><Positioning Attribute><Property><Publishing><R21 Mechanism><R21 Program><RNA Expression><Reproducibility><Role><Specificity><Subcellular Process><T cell response><T-Cell Development><T-Cell Ontogeny><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Development><T-Lymphocyte Subsets><T-cell receptor repertoire><T4 Cells><T4 Lymphocytes><T8 Cells><T8 Lymphocytes><TCR repertoire><Testing><Therapeutic><Thymus><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Time><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Uncertainty><Vaccination><Work><autoimmune condition><autoimmune disorder><autoimmunity disease><developmental><doubt><exploratory developmental study><gene expression pattern><gene expression signature><host response><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunopathology><immunoregulation><immunoregulatory><immunoresponse><interest><malignancy><mouse model><murine model><neoplasm/cancer><pathogen><premature><prematurity><prevent><preventing><restraint><social role><thymus derived lymphocyte><transcription factor><transcriptional profile><transcriptional signature>
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Hyun Jung Kim

CLEVELAND CLINIC LERNER COM-CWRU, CLEVELAND, OH

Exploratory lead · 32/100
Solid budget
Recent
Active award
$400,890
FY 2026

Project Title

Microbiome-Mediated Tumor Immunomodulation in a Pathomimetic Colorectal Cancer Chip

Grant Number:

5R33CA286797-02

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2028

Project Abstract

ABSTRACT Immune checkpoint inhibitors (ICI) have demonstrated notable efficacy in various cancers, yet the majority of colorectal cancer (CRC) patients with mismatch repair-proficient (MMR-p) and microsatellite-stable (MSS) tumors do not respond to ICI-based immunotherapy. Recent research suggests t...

Research Terms

<3-D><3-D Imaging><3-Dimensional><3D><3D imaging><B7-H1><Bifidobacterium><CD152><CD152 Antigen><CD152 Gene><CD274><CTLA 4><CTLA-4 Gene><CTLA4><CTLA4 gene><CTLA4-TM><Cancers><Cell Body><Cell-Mediated Lympholytic Cells><Cells><Characteristics><Checkpoint inhibitor><Clinical><Co-culture><Cocultivation><Coculture><Coculture Techniques><Colon><Colorectal Cancer><Colorectal Neoplasms><Colorectal Tumors><Complex><Cytolytic T-Cell><Cytotoxic T Cell><Cytotoxic T-Lymphocyte Protein 4><Cytotoxic T-Lymphocyte-Associated Antigen 4><Cytotoxic T-Lymphocyte-Associated Protein 4><Cytotoxic T-Lymphocyte-Associated Serine Esterase-4><Cytotoxic T-Lymphocytes><Data Bases><Databases><Defecation><Demographic Impact><Demography><ELISA><Enzyme-Linked Immunosorbent Assay><Epithelial Cells><Epithelium><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Exploratory/Developmental Grant><Female><Fusobacterium><GI microbiome><GI microbiota><Gastrointestinal microbiota><Genetic><Germ-Free><Goals><Image><Immune checkpoint inhibitor><Immune infiltrates><Immune mediated therapy><Immunofluorescence><Immunofluorescence Immunologic><Immunologically Directed Therapy><Immunomodulation><Immunotherapeutic agent><Immunotherapy><In Situ Hybridization><Intratumoral heterogeneity><Investigation><Knowledge><Large Bowel Tumor><Large Intestine Neoplasm><Large Intestine Tumor><Malignant Neoplasms><Malignant Tumor><Mediating><Microbe><Microbial Taxonomy><Microsatellite Markers><Microsatellite Repeats><Microsatellites><Mismatch Repair><Molecular><Molecular Analysis><Non-Polyadenylated RNA><Normal Tissue><Normal tissue morphology><O element><O2 element><Organoids><Outcome><Oxygen><PD 1><PD-1><PD-L1><PD1><PDL-1><Pathologic><Patients><Phenotype><Physiology><Post-Replication Mismatch Repair><Programmed Cell Death 1 Ligand 1><Programmed Death Ligand 1><Proteins><R21 Mechanism><R21 Program><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Racial Group><Reproducibility><Research><Ribonucleic Acid><Running><Solid Neoplasm><Solid Tumor><Sphaerophorus><Technology><Testing><Therapeutic><Three-Dimensional Imaging><Validation><Vascularization><Visual><Visualization><analyze microbiome><anti-cancer><anti-cancer immunotherapy><anti-cancer therapeutic><anti-tumor drug><anticancer immunotherapy><bowel movement><cancer immunotherapy><cancer microenvironment><chip model><chip system><colon cancer patients><colorectal cancer patients><colorectal neoplasia><cytotoxic T-lymphocyte antigen 4><data base><digestive tract microbiome><enteric microbial community><enteric microbiome><enteric microbiota><enzyme linked immunoassay><ethnic subgroup><ethnicity group><exploratory developmental study><fecal microbial community><fecal microbial transplantation><fecal microbiome transplantation><fecal microbiota><fecal microbiota transplant><fecal microbiota transplantation><fecal transplant><fecal transplantation><fluid flow><gastrointestinal microbial flora><gastrointestinal microbiome><global gene expression><global transcription profile><gut community><gut flora><gut microbe community><gut microbial community><gut microbial composition><gut microbial consortia><gut microbiome><gut microbiota><gut microbiotic><gut microflora><gut-associated microbiome><heterogeneity in tumors><host microbiome><imaging><immune cell infiltrate><immune check point><immune check point inhibitor><immune checkpoint><immune clearance><immune drugs><immune elimination><immune modulation><immune regulation><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapeutics><immune-based therapies><immune-based treatments><immunecheckpoint><immuno therapy><immunogenicity><immunologic reactivity control><immunologic therapeutics><immunomodulatory><immunoregulation><immunoregulatory><immunotherapeutics><immunotherapy agent><immunotherapy for cancer><immunotherapy of cancer><improved><in situ Hybridization Genetics><in situ Hybridization Staining Method><innovate><innovation><innovative><intestinal biome><intestinal epithelium><intestinal flora><intestinal microbiome><intestinal microbiota><intestinal microflora><intestinal tract microflora><intra-tumoral heterogeneity><intratumor heterogeneity><killer T cell><large bowel neoplasm><male><malignancy><microbial><microbial signature><microbiome><microbiome analysis><microphysiologic model><microphysiologic platform><microphysiologic system><microphysiology model><microphysiology platform><microphysiology system><molecular phenotype><neoplasm/cancer><new technology><novel technologies><on a chip><on chip><patient profile><pre-clinical><prebiotics><preclinical><probiotic supplement><probiotic supplementation><profiles in patients><programmed cell death 1><programmed cell death ligand 1><programmed cell death protein 1><programmed cell death protein ligand 1><programmed death 1><prophylactic><protein death-ligand 1><racial population><racial subgroup><response><sle2><socio-demographics><sociodemographics><supplementation with probiotics><systemic lupus erythematosus susceptibility 2><technology platform><technology system><therapeutic outcome><therapy outcome><three dimensional><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><translational impact><tumor><tumor eradication><tumor heterogeneity><tumor microbiome><tumor microbiota><tumor microenvironment><tumor-associated microbiome><tumor-associated microbiota><validations><♀><♂>
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Jamal S Lewis

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 32/100
Solid budget
Recent
Active award
$392,142
FY 2026

Project Title

Commensal bacteria-derived nanoparticles for correcting gut inflammation

Grant Number:

1R21AI196729-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/18/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY/ ABSTRACT: Currently, the therapeutic options available to individuals with inflammatory bowel disorder (IBD) are limited to small molecule drug and biologics with high toxicity and off-target effects. IBD (and gut dysbiosis) have been directly linked to a plethora of metabolic, neu...

Research Terms

<Address><Affect><Alimentary Canal><Allergic Disease><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antibodies><Antigen Presentation><Antigen-Presenting Cells><Antigenic Determinants><Antigens><Area><Artificial nano particles><Artificial nanoparticles><Attenuated><Autoimmune Diseases><Autoimmune Status><Autoimmunity><B fragilis><B. fragilis><Bacteria><Bacteroides><Bacteroides fragilis><Binding Determinants><Biochemical><Biocompatible Materials><Biodistribution><Biological Agent><Biological Products><Biomaterials><Biophysics><CSIF><CSIF-10><Capsules><Cell Body><Cell Communication><Cell Communication and Signaling><Cell Interaction><Cell Signaling><Cell-to-Cell Interaction><Cells><Clinical Treatment Moab><Colitis><Colon><Colorectal Cancer><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><Cytokine Synthesis Inhibitory Factor><Defect><Dendritic Cells><Digestive Tract><Disease><Disorder><Drug Kinetics><Drugs><Engineering><Environment><Epithelium><Epitopes><Equilibrium><GI Tract><GI microbiota><Gastrointestinal Tract><Gastrointestinal microbiota><Gastrointestinal tract structure><Generations><Glycans><Goals><Granulomatous Enteritis><HPLC><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Human><IL-10><IL10><IL10A><Immune><Immune Cell Activation><Immune Tolerance><Immunes><Immunity><Immunologic Tolerance><Immunology><Immunomodulation><In Vitro><Individual><Inflammation><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Inflammatory Response><Interleukin 10 Precursor><Interleukin-10><Intestinal><Intestines><Intracellular Communication and Signaling><Link><Literature><Macrophage><Medication><Mental disorders><Mental health disorders><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Glycosylation><Mice><Mice Mammals><Microbiology><Mission><Modern Man><Molecular Configuration><Molecular Conformation><Molecular Stereochemistry><Monoclonal Antibodies><Mucosa><Mucosal Tissue><Mucous Membrane><Murine><Mus><Mφ><NIAID><National Institute of Allergy and Infectious Disease><Oral><Oral Administration><Oral Drug Administration><Outcome><Patients><Pharmaceutical Preparations><Pharmacokinetics><Polymers><Polysaccharides><Production><Property><Proteins><Psychiatric Disease><Psychiatric Disorder><Public Health><Reaction><Regulatory T-Lymphocyte><Reporting><Research><Role><Signal Transduction><Signal Transduction Systems><Signaling><System><T-Cells><T-Lymphocyte><TIL4><TLR2><TLR2 gene><TLR2 receptor><Therapeutic><Therapeutic Agents><Thesaurismosis><Toll-Like Receptor 2><Toll/Interleukin 1 Receptor-Like 4><Toll/Interleukin 1 Receptor-Like 4 Gene><Toll/Interleukin 1 Receptor-Like Protein 4><Toxic effect><Toxicities><Treg><Tropomyosin><Ulcerated Colitis><Ulcerative Colitis><Veiled Cells><accessory cell><alimentary tract><anergy><attenuate><attenuates><attenuation><autoimmune condition><autoimmune disorder><autoimmunity disease><autoinflammatory><balance><balance function><biological material><biological signal transduction><biologics><biopharmaceutical><biophysical foundation><biophysical principles><biophysical sciences><biotherapeutic agent><bowel><bowel inflammation><capsule><colitis mouse model><colitis murine model><commensal bacteria><commensal bacterial species><conformation><conformational><conformational state><conformationally><conformations><cytokine><design><designing><digestive canal><drug/agent><eleocolitis><engineered immune system><engineered nano particle><engineered nanoparticle><enteric microbial community><enteric microbiota><gastrointestinal microbial flora><global gene expression><global transcription profile><glycosylation><gut community><gut dysbiosis><gut flora><gut inflammation><gut microbe community><gut microbes><gut microbial community><gut microbial composition><gut microbial consortia><gut microbial species><gut microbiota><gut microbiotic><gut microflora><immune activation><immune engineering><immune modulation><immune regulation><immune system tolerance><immune unresponsiveness><immunoengineering><immunogen><immunogenic><immunologic reactivity control><immunological paralysis><immunomodulatory><immunoregulation><immunoregulatory><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><intestinal autoinflammation><intestinal flora><intestinal inflammation><intestinal microbes><intestinal microbiota><intestinal microflora><intestinal tract microflora><intraoral drug delivery><mAbs><manufacture><mental illness><metabolism disorder><microbiome community composition><microbiome composition><microbiome species composition><microbiome structure><monoclonal Abs><mouse colitis><mouse model><murine colitis><murine model><nano particle><nano-sized particle><nanoparticle><nanosized particle><neural><novel><pathogen><polymer><polymeric><psychiatric illness><psychological disorder><regional enteritis><regulatory T-cells><response><small molecule><social role><thymus derived lymphocyte><transcriptome><translational impact>
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SEONJOO LEE

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 32/100
Solid budget
Recent
Active award
$390,122
FY 2026

Project Title

Novel Group ICA Incorporating Time-Frequency Information for Longitudinal Brain Network Analysis

Grant Number:

1R21AG093534-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/29/2028

Project Abstract

Abstract This R21 application aims to develop a novel group independent component analysis (ICA) algorithm, incorporating time-frequency information (GtfICA) to capture the temporal dynamics of functional networks (dFN) in longitudinal studies. The GrfICA will provide a comprehensive view of the spa...

Research Terms

<18 year old><18 years of age><AD and related dementia><AD related dementia><ADRD><Active Follow-up><Address><Aging><Algorithmic Analyses><Algorithmic Analysis><Algorithms><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Analyses of Algorithms><Analysis of Algorithms><Attention><Brain><Brain Nervous System><Cell Communication and Signaling><Cell Signaling><Clinical><Cognitive><Cognitive aging><Data><Degenerative Neurologic Disorders><Encephalon><Frequencies><Functional MRI><Functional Magnetic Resonance Imaging><Future><Image><Intracellular Communication and Signaling><Longitudinal Studies><Longitudinal Surveys><Measures><Methods><Nervous System Degenerative Diseases><Network Analysis><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Outcome><Participant><Pathway Analysis><Pattern><Performance><Population><Population Heterogeneity><Protocol><Protocols documentation><Reproducibility><Reproducibility of Findings><Reproducibility of Results><Research><Rest><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Source><Technology><Testing><Time><Visit><active followup><age 18><age 18 years><age associated><age associated alterations><age associated changes><age associated difference><age associated effects><age based difference><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent difference><age dependent variation><age difference><age effect><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related difference><age related effects><age related variation><age specific><age specific alterations><age specific changes><age specific difference><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><biological signal transduction><changes with age><cognitive process><cognitive task><data integration><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><differ by age><difference across age><difference in age><diverse populations><eighteen year old><eighteen years of age><experiment><experimental research><experimental study><experiments><fMRI><feature extraction><follow up><follow-up><followed up><followup><functional independence><heterogeneous population><imaging><impact of age><improved><independent component analysis><influence of age><long-term study><longitudinal outcome studies><longitudinal research study><neurodegenerative illness><new approaches><novel><novel approaches><novel strategies><novel strategy><population diversity><rate of change><spatial and temporal><spatial temporal><spatiotemporal><variation by age>
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DEBRA J. UMBERSON

UNIVERSITY OF TEXAS AT AUSTIN, AUSTIN, TX

Exploratory lead · 32/100
Solid budget
Recent
Active award
$330,731
FY 2026

Project Title

How Spouses Influence Each Other's Health in Same- and Different-Sex Marriages: A Dyadic and Longitudinal Assessment from Mid to Later Life

Grant Number:

5R37AG076057-05

Activity Code:

R37

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2022

End Date:

4/15/2027

Project Abstract

Abstract Decades of population research show that married Americans are in better health and live longer than their unmarried peers and that there are gender differences in how spouses influence each other’s health. Until recently, however, this research was entirely based on marriages between women...

Research Terms

<Active Follow-up><Affect><Age><Aging><Alcohol Drinking><Alcohol consumption><American><Baseline Surveys><Behavior><Behavioral><Biological><Couples><Data><Data Analyses><Data Analysis><Data Collection><Data Set><Distress><Emotional><EtOH drinking><EtOH use><Exploratory/Developmental Grant><Gays><Gender><Gender Relations><Goals><Health><Health Status><Health behavior><Heterosexuals><History><Individual><Knowledge><Lead><Legal><Lesbian><Level of Health><Life><Link><Long-Term Effects><Marriage><Married Persons><Mediating><Mental Depression><Mental Health><Mental Hygiene><Obesity><Outcome><Pathway interactions><Pattern><Pb element><Personal Satisfaction><Policies><Population Research><Population-based research><Population-level research><Process><Productivity><Psychological Health><Publications><R21 Mechanism><R21 Program><Recording of previous events><Research><Risk><Same-sex><Scientific Advances and Accomplishments><Scientific Publication><Scientist><Shapes><Spouses><Stress><Survey Instrument><Surveys><Thinking><Time><Transmission><Unmarried><Variant><Variation><Woman><active followup><adiposity><age associated><age correlated><age dependent><age linked><age related><age specific><ages><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><biologic><care giving><caregiving><corpulence><data interpretation><depression><diaries><differences in health><emotion regulation><emotional regulation><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><evidence base><experience><exploratory developmental study><follow up><follow-up><followed up><followup><gender difference><gender-associated difference><health difference><health level><health related behavior><heavy metal Pb><heavy metal lead><histories><innovate><innovation><innovative><investigate population><later in life><later life><longitudinal design><longitudinal experimental design><longitudinal research design><longitudinal study design><men><mid life><mid-life><middle age><middle aged><midlife><novel><pathway><peer><physical conditioning><physical health><physical symptom><population investigation><population level investigation><population specific research><psychologic><psychological><psychological symptom><resilience><resilient><response><same sex partner><same sex relationship><same-sex couple><same-sex partnership><scientific accomplishments><scientific advances><sex><social><studies of populations><study of the population><study population><survey population><thoughts><transmission process><well-being><wellbeing>
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Ziyad Ben Taleb

UNIVERSITY OF TEXAS ARLINGTON, ARLINGTON, TX

Exploratory lead · 30/100
Very recent
Active award
$247,878
FY 2026

Project Title

Impact of Waterpipe Size and Heating Source on Exposure, Behavior, and Abuse Liability

Grant Number:

1R21DA062897-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Waterpipe (WP) tobacco smoking remains an important public health concern among young adults in the US, with 1 in 8 reporting past year use. Like cigarettes, WP smoking can lead to cancer, impaired pulmonary function, and heart disease due to toxicants such as carcinogenic polycyclic aromatic hydroc...

Research Terms

<21 year old><21 years of age><Address><Aldehydes><Aromatic Polycyclic Hydrocarbons><Behavior><Cancers><Carbon Monoxide><Cardiac Diseases><Cardiac Disorders><Charcoal><Cigarette><Clinical><Common Market><Complex><Cor pulmonale><Cross-Over Studies><Crossover Studies><Data><Development><Devices><Dimensions><Drug usage><Enrollment><Ensure><European Common Market><European Economic Community><Evaluation><Exhalation><Exhaling><Exposure to><Filtration><Filtration Fractionation><Formulation><Future><HAZMAT><Harm Minimization><Harm Reduction><Hazardous Materials><Hazardous Substances><Health><Health Policy><Heart Diseases><Heating><Height><Impairment><Individual><Industry><Inhalation><Inhaling><Intervention><Knowledge><Lung Diseases><Malignant Neoplasms><Malignant Tumor><Marketing><Measures><Methods><Minnesota><Mission><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Nicotine><Nicotine Withdrawal><Outcome><Participant><Patient Self-Report><Perception><Public Health><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Heart Disease><Pulmonary Heart Disorder><Questionnaires><Regulation><Reporting><Research><Respiratory Expiration><Risk><Role><Sales><Saliva><Science><Scientific Advances and Accomplishments><Self-Report><Sensory><Shapes><Smoke><Smoker><Smoking><Smoking Behavior><Source><Standardization><Testing><Tobacco><Tobacco smoking><Tobacco smoking behavior><Toxicant exposure><Volatilization><Work><abuse liability><abuse potential><addiction liability><addiction potential><adult youth><age 21><age 21 years><carcinogenicity><cardiopulmonary disease><cardiopulmonary disorder><developmental><disease of the lung><disorder of the lung><drug use><enroll><experience><exposure to nicotine><haz mat><health care policy><heart disorder><hookah><improved><lung disorder><lung function><malignancy><manufacture><narghile><neoplasm/cancer><nicotine exposure><novel><polyaromatic hydrocarbons><polynuclear aromatic hydrocarbon><pulmonary function><satisfaction><scientific accomplishments><scientific advances><shisha><smoke inhalation><smoking exposure><social role><toxic exposure><toxicant><twenty-one year old><twenty-one years of age><water pipe><waterpipe><young adult><young adult age><young adulthood>
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RUI ZHAO

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 30/100
Very recent
Active award
$234,000
FY 2026

Project Title

Understanding small molecule modulation of splicing for Huntington's disease therapy

Grant Number:

5R21NS142950-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary: Small molecule splicing modulators have emerged recently as exciting new approaches to efficiently modulate protein levels in genetic diseases that affected the CNS. One such compound, risdiplam, is orally bioavailable with excellent CNS distribution and has been approved by the FDA in 2020...

Research Terms

<Affect><Antisense Agent><Antisense Oligonucleotides><Aran-Duchenne disease><Binding><Bioavailability><Biochemical><Biological Availability><CAG repeat><CAG trinucleotide repeat><CNS Diseases><CNS disorder><Central Nervous System Diseases><Central Nervous System Disorders><Complex><Cruveilhier disease><Cryo-electron Microscopy><Cryoelectron Microscopy><Crystallization><Crystallographies><Crystallography><Degenerative Neurologic Disorders><Development><Drug Therapy><Drugs><Electron Cryomicroscopy><Exons><FDA approved><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fluorescence Polarization><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Future><Genes><Genetic Diseases><Goals><Grant><HD Gene><HD protein><Human><Huntingtin><Huntingtin Protein><Huntington Chorea><Huntington Disease><Huntington gene><Huntington protein><Huntington's><Huntington's Disease><Huntington's disease gene product><Huntingtons Disease><IT15 gene><Intervening Sequences><Intervention><Introns><Mediating><Medication><Messenger RNA><MicroRNAs><Modern Man><Molecular Interaction><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Disorders><Non-Polyadenylated RNA><Non-sense Mediated Decay><Nonsense Codon><Nonsense-Mediated Decay><Nucleic Acids><Oligo><Oligonucleotides><Oral><PNS Diseases><Pathogenicity><Peripheral><Peripheral Nerve Diseases><Peripheral Nervous System Diseases><Peripheral Nervous System Disorders><Peripheral Neuropathy><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phase><Phase 2 Clinical Trials><Phase II Clinical Trials><Physiologic Availability><Poison><Post-Transcriptional Gene Silencing><Premature Stop Codon><Process><Proteins><RNA><RNA Gene Products><RNA Interference><RNA Silencing><RNA Splicing><RNAi><Resolution><Ribonucleic Acid><Ribonucleoproteins, Small, U1><SMN gene product (SMA)><SMN protein><SMN protein (spinal muscular atrophy)><Sequence-Specific Posttranscriptional Gene Silencing><Site><Specificity><Spinal Muscular Atrophy><Splicing><Structure><System><Testing><Therapeutic><Toxic Chemical><Toxic Substance><U1 RNA><U1 Small Nuclear Ribonucleoprotein><U1 small nuclear RNA><U1 snRNA><U1 snRNP><Work><Yeasts><analog><antisense oligo><compound optimization><cryo-EM><cryoEM><cryogenic electron microscopy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><drug development><drug intervention><drug treatment><drug/agent><effective therapy><effective treatment><experiment><experimental research><experimental study><experiments><formulation optimization><functional group><genetic condition><genetic disorder><improved><interesting transcript 15><mRNA><mRNA Decay><member><miRNA><mouse model><murine model><mutant><neurodegenerative illness><neurological disease><new approaches><novel approaches><novel strategies><novel strategy><oligos><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phase II protocol><reconstitute><reconstitution><resolutions><shRNA><short hairpin RNA><small hairpin RNA><small molecule><success><survival motor neuron gene product><survival motor neuron protein><tool><toxic compound>
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KEITH R JEROME

FRED HUTCHINSON CANCER CENTER, SEATTLE, WA

Exploratory lead · 30/100
Very recent
Active award
$232,558
FY 2026

Project Title

AAV-delivered meganucleases for durable control of genital HSV disease

Grant Number:

1R21AI195413-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/13/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project summary Herpes simplex virus (HSV) establishes latency in ganglionic neurons of the peripheral nervous system. Latent HSV can later reactivate, causing recurrent disease and possible transmission to new hosts. Current anti-HSV therapy is inadequate, in that it does not eliminate latent HSV, ...

Research Terms

<AAV delivered><AAV delivery><AAV vector><AAV-based delivery><AAV-based vector><AAV-based viral delivery><AAV-mediated delivery><Address><Adeno-Associated Viruses><Adeno-associated-virus-based delivery><After Care><After-Treatment><Aftercare><Animals><Aran-Duchenne disease><Bathing><Baths><Biodistribution><Biology><Blood Serum><Body Tissues><Bromodomain><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cerebrospinal Fluid><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Control Animal><Coupled><Cruveilhier disease><DNA Therapy><Data><Dependoparvovirus><Dependovirus><Dorsal Root Ganglia><Dose><Evaluation><Event><Exposure to><FDA approved><Frequencies><GUIDE-seq><Ganglia><Gene Transfer Clinical><Genes><Genetic Intervention><Genital Herpes Simplex><Genome><Genome-wide Unbiased Identification of DSBs Enabled by sequencing><Genomics><HHV-2><HHV2><HIV Infections><HIV viral infection><HIV virus infection><HIV-1 infection><HSV><HSV vector><HSV-1><HSV-2><HSV1><HSV2><Herpes Genitalis><Herpes Simplex><Herpes Simplex Infections><Herpes Simplex Type 1><Herpes Simplex Virus><Herpes Simplex Virus 1><Herpes Simplex Virus 2><Herpes Simplex Virus Type 1><Herpes Simplex Virus Type 2><Herpes Simplex Virus Vector><Herpes labialis Virus><Herpes simplex disease><Herpesvirus 1><Herpesvirus 2 (alpha), Human><Herpesvirus hominis disease><Herpesvirus progenitalis><Human><Human (alpha) herpes virus 2><Human Herpesvirus 2><Human herpes simplex virus type 2><Hybrid capture><Hybridization capture><Immunity><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Intrathecal Injections><Intravenous><Longitudinal Studies><Longitudinal Surveys><Lumbar Puncture><Maximal Tolerated Dose><Maximally Tolerated Dose><Maximum Tolerated Dose><Mediating><Mice><Mice Mammals><Modern Man><Murine><Mus><NGS Method><NGS system><NIH><National Institutes of Health><Natural History><Nerve Cells><Nerve Unit><Neural Cell><Neural Ganglion><Neurocyte><Neurons><Peripheral><Peripheral Nervous System><Phase><Protein Family><Proteins><Recurrence><Recurrent><Recurrent disease><Relapsed Disease><Reproducibility><Research><Route><Safety><Serotyping><Serum><Simplexvirus><Specificity><Spinal Ganglia><Spinal Muscular Atrophy><Spinal Puncture><Strategic Planning><Testing><Therapeutic><Therapeutic Gene Editing><Time><Tissues><Toxic effect><Toxicities><Translating><Translations><Transmission><Treatment Efficacy><United States National Institutes of Health><Viral><Viral Burden><Viral Diseases><Viral Load><Viral Load result><Viral Shedding><Viral load measurement><Viral reservoir><Virus><Virus Diseases><Virus Shedding><Virus reservoir><Virus-Genital Herpes><Work><adeno associated virus group><adeno-associated viral vector><adeno-associated viral vector delivery><adeno-associated virus delivery><adeno-associated virus mediated delivery><adeno-associated virus vector><adenovirus mediated delivery><anti-viral efficacy><cerebral spinal fluid><clinical translation><clinically translatable><delivered with AAV><delivery with AAV><design><designing><detection method><detection procedure><detection technique><dorsal root ganglion><experiment><experimental research><experimental study><experiments><gene repair therapy><gene therapy><gene-based therapy><gene-editing therapy><genetic therapy><genital herpes><genital infection><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genomic therapy><genotoxicity><herpes genitalia><herpes simplex i><herpes simplex ii><herpes simplex virus 1 infection><herpes simplex virus infection><herpes simplex-1><human alphaherpesvirus 2><human immunodeficiency virus infection><hybridization-based capture><improved><in vivo><infected vaginally><infected with HIV><infected with human immunodeficiency virus><inhibitor><insight><intervention efficacy><intravenous administration><latent infection><long-term study><longitudinal outcome studies><longitudinal research study><mouse model><murine model><neuronal><neutralizing antibody><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next gen sequencing><next generation sequencing><nextgen sequencing><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><pharmacologic><post treatment><response><spinal fluid><therapeutic editing><therapeutic efficacy><therapeutic genome editing><therapy duration><therapy efficacy><translation><transmission process><vaginal infection><vector><venereal herpes><viral DNA><viral infection><virus DNA><virus infection><virus load><virus-induced disease>
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Mark T Heise

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 30/100
Very recent
Active award
$229,714
FY 2026

Project Title

RNA Ribosylation's Role in Viral RNA Biology and Innate Immunity

Grant Number:

1R21AI196787-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/13/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT ABSTRACT Post-transcriptional mRNA modifications have a major impact on viral RNA stability, translation efficiency, and sensing by the host innate immune system. Therefore, understanding how RNA modifications affect viral replication and/or host innate immune sensing is essential for unders...

Research Terms

<ADP Ribose><ADP ribosylation><Adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose><Adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose, homopolymer><Adenosine 5'-Diphosphoribose><Adenosine Diphosphate Ribose><Adenosine Diphosphoribose><Affect><Alpha Virus><Anti-viral Response><Arthritis><Automobile Driving><Binding><Biochemical><Biology><CHIKV><Cell Body><Cell Communication and Signaling><Cell Extracts><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Stress><Cellular Stress Response><Chikungunya virus><Complex><Coronaviridae><Coronavirus><Data><Disease><Disorder><Gene Expression><Genes><Group A Arboviruses><Human><IFN><Immune><Immune response><Immunes><In Vitro><Infection><Initiation Factors><Innate Immune Response><Innate Immune System><Innate Immunity><Interferons><Intracellular Communication and Signaling><Mammalian Cell><Mediating><Messenger RNA><Methylation><Modern Man><Modification><Molecular><Molecular Interaction><Molecular Virology><Native Immunity><Natural Immunity><Non-Polyadenylated RNA><Non-Specific Immunity><Nonspecific Immunity><Orthocoronavirinae><PARP Polymerase><PARP protein><PARS><Pattern><Pattern Recognition><Peptide Domain><Peptide Initiation Factors><Play><Poly Adenosine Diphosphate Ribose><Poly(ADP-ribose) Polymerases><Poly(ADPribose) Polymerase><Poly-ADPR><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Protein Biosynthesis><Protein Domains><Protein Modification><Proteins><RNA><RNA Degradation><RNA Gene Products><RNA Stability><RNA Viruses><RNA analysis><RNA chemical synthesis><RNA synthesis><Regulation><Ribonucleic Acid><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Ribosomes><Role><Sarbecovirus><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><System><Techniques><Tertiary Protein Structure><Testing><Translating><Translation Initiation Factor><Translational Initiation Factor><Translations><Viral><Viral Activity><Viral Diseases><Viral Function><Viral Gene Products><Viral Gene Proteins><Viral Genes><Viral Physiology><Viral Proteins><Virion><Virus><Virus Diseases><Virus Particle><Virus Replication><Zinc Finger Domain><Zinc Finger Motifs><Zinc Fingers><arthritic><biological signal transduction><cell stress><corona virus><driving><emerging pathogen><genomic RNA><host response><immune system response><immunoresponse><innate immune sensing><innovate><innovation><innovative><insight><mRNA><mRNA Stability><mRNA Translation><mutant><new pathogen><novel><novel pathogen><obligate intracellular parasite><pathogen><poly (ADP-ribose)><poly ADP polymerase><poly ADP ribose synthetase><posttranscriptional><protein expression><protein synthesis><sensor><social role><translation><viral RNA><viral infection><viral multiplication><viral replication><virus RNA><virus infection><virus multiplication><virus protein><virus-induced disease>
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Nathaniel J Moorman

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 30/100
Very recent
Active award
$229,714
FY 2026

Project Title

RNA Ribosylation's Role in Viral RNA Biology and Innate Immunity

Grant Number:

1R21AI196787-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/13/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT ABSTRACT Post-transcriptional mRNA modifications have a major impact on viral RNA stability, translation efficiency, and sensing by the host innate immune system. Therefore, understanding how RNA modifications affect viral replication and/or host innate immune sensing is essential for unders...

Research Terms

<ADP Ribose><ADP ribosylation><Adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose><Adenosine 5'-(trihydrogen diphosphate), P'-5-ester with D-ribose, homopolymer><Adenosine 5'-Diphosphoribose><Adenosine Diphosphate Ribose><Adenosine Diphosphoribose><Affect><Alpha Virus><Anti-viral Response><Arthritis><Automobile Driving><Binding><Biochemical><Biology><CHIKV><Cell Body><Cell Communication and Signaling><Cell Extracts><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Stress><Cellular Stress Response><Chikungunya virus><Complex><Coronaviridae><Coronavirus><Data><Disease><Disorder><Gene Expression><Genes><Group A Arboviruses><Human><IFN><Immune><Immune response><Immunes><In Vitro><Infection><Initiation Factors><Innate Immune Response><Innate Immune System><Innate Immunity><Interferons><Intracellular Communication and Signaling><Mammalian Cell><Mediating><Messenger RNA><Methylation><Modern Man><Modification><Molecular><Molecular Interaction><Molecular Virology><Native Immunity><Natural Immunity><Non-Polyadenylated RNA><Non-Specific Immunity><Nonspecific Immunity><Orthocoronavirinae><PARP Polymerase><PARP protein><PARS><Pattern><Pattern Recognition><Peptide Domain><Peptide Initiation Factors><Play><Poly Adenosine Diphosphate Ribose><Poly(ADP-ribose) Polymerases><Poly(ADPribose) Polymerase><Poly-ADPR><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Protein Biosynthesis><Protein Domains><Protein Modification><Proteins><RNA><RNA Degradation><RNA Gene Products><RNA Stability><RNA Viruses><RNA analysis><RNA chemical synthesis><RNA synthesis><Regulation><Ribonucleic Acid><Ribosomal Peptide Biosynthesis><Ribosomal Protein Biosynthesis><Ribosomal Protein Synthesis><Ribosomes><Role><Sarbecovirus><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><System><Techniques><Tertiary Protein Structure><Testing><Translating><Translation Initiation Factor><Translational Initiation Factor><Translations><Viral><Viral Activity><Viral Diseases><Viral Function><Viral Gene Products><Viral Gene Proteins><Viral Genes><Viral Physiology><Viral Proteins><Virion><Virus><Virus Diseases><Virus Particle><Virus Replication><Zinc Finger Domain><Zinc Finger Motifs><Zinc Fingers><arthritic><biological signal transduction><cell stress><corona virus><driving><emerging pathogen><genomic RNA><host response><immune system response><immunoresponse><innate immune sensing><innovate><innovation><innovative><insight><mRNA><mRNA Stability><mRNA Translation><mutant><new pathogen><novel><novel pathogen><obligate intracellular parasite><pathogen><poly (ADP-ribose)><poly ADP polymerase><poly ADP ribose synthetase><posttranscriptional><protein expression><protein synthesis><sensor><social role><translation><viral RNA><viral infection><viral multiplication><viral replication><virus RNA><virus infection><virus multiplication><virus protein><virus-induced disease>
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Mark T Heise

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 30/100
Very recent
Active award
$229,360
FY 2026

Project Title

Impact of Host Genetic Variants on Regulating Chikungunya Virus-Induced Disease

Grant Number:

1R21AI196703-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT ABSTRACT Chikungunya virus (CHIKV) is an emerging mosquito-borne alphavirus that causes major epidemics of both acute and chronic arthralgia. Humans exhibit significant variation in CHIKV disease susceptibility, with outcomes ranging from severe debilitating arthritis to asymptomatic infecti...

Research Terms

<Active Follow-up><Acute><Affect><Alpha Virus><Americas><Arthralgia><Arthritis><Asia><Automobile Driving><C57BL/6 Mouse><CHIKV><CHIKV arthritis><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chikungunya arthritis><Chikungunya virus><Chromosome 8><Chromosome Mapping><Chronic><Code><Coding System><Data><Diathesis><Disease><Disease Outbreaks><Disease Outcome><Disease Resistance><Disease susceptibility><Disorder><Epidemic><Exhibits><Exploratory/Developmental Grant><Future><GWA study><GWAS><Gene Expression><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene variant><Genes><Genetic><Genetic Diversity><Genetic Screening><Genetic Variation><Goals><Group A Arboviruses><Haplotypes><Human><Human Genetics><Immune response><Inbred Strains Mice><Indian Ocean><Infection><Inflammatory><Inflammatory Muscle Diseases><Inflammatory Myopathy><Inflammatory Response><Intracellular Communication and Signaling><Joint Diseases><Joint Pain><Knowledge><Linkage Mapping><Maps><Mediating><Mice><Mice Mammals><Modern Man><Monitor><Mouse Strains><Murine><Mus><Myositis><Nature><Other Genetics><Outbreaks><Outcome><Pathogenesis><Pathway interactions><Pattern><Phenotype><Population><Predisposition><Puerto Rico><QTL><Quantitative Trait Loci><R21 Mechanism><R21 Program><Reporting><Research Resources><Resistance><Resources><Role><Severity of illness><Signal Transduction><Signal Transduction Systems><Signaling><Susceptibility><Swelling><Tendinitis><Tendinopathy><Tendonitis><Therapeutic Intervention><Total Human and Non-Human Gene Mapping><Validation><Variant><Variation><Viral Diseases><Viral Pathogenesis><Virus><Virus Diseases><Virus Replication><active followup><allelic variant><arthritic><arthropathic><arthropathies><arthropathy><biological signal transduction><candidate validation><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><chikungunya viral arthritis><chikungunya virus arthritis><chikungunya virus-induced arthritis><design><designing><develop therapy><disease phenotype><disease severity><driving><exploratory developmental study><follow up><follow-up><followed up><followup><foot><gene locus><genetic locus><genetic mapping><genetic variant><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic location><genomic locus><genomic variant><host response><human model><immune system response><immunoresponse><inflamed joint><insight><intervention development><intervention therapy><joint disorder><joint inflammation><joint swelling><liability to disease><model of human><mosquito-borne><mosquitoborne><mouse genetics><mouse model><murine model><pathway><resistance gene><resistance locus><resistance to disease><resistant><resistant disease><resistant gene><resistant to disease><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapy development><treatment development><validation studies><validations><viral infection><viral multiplication><viral replication><viral resistance><virus infection><virus multiplication><virus pathogenesis><virus resistance><virus-induced disease><whole genome association analysis><whole genome association study>
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Jacob Nordman

SOUTHERN ILLINOIS UNIVERSITY CARBONDALE, CARBONDALE, IL

Exploratory lead · 30/100
Very recent
Active award
$222,750
FY 2026

Project Title

Neural mechanisms of socially transmitted aggression

Grant Number:

5R21MH136446-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Background: Aggression can be learned by observing the aggressive behavior of others, which can be advantageous for survival, but can also have severe consequences for the individual and society at large. Notably, children frequently exposed to aggressive behavior have an increased risk of engaging ...

Research Terms

<0-11 years old><Address><Affective><Aggression><Aggressive behavior><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anger><Animal Model><Animal Models and Related Studies><Animals><Behavior><Behavioral Paradigm><Brain><Brain Nervous System><Brain region><Chemosensitization><Chemosensitization/Potentiation><Child><Child Youth><Children (0-21)><Data><Development><Electrophysiology><Electrophysiology (science)><Encephalon><Ethics><Exploratory/Developmental Grant><Exposure to><FBJ osteosarcoma oncogene><FOS gene><Familiarity><Fear><Female><Fright><G0S7><Genetic><Goals><Human><Hypothalamic structure><Hypothalamus><Individual><Intervention><Learning><Long-Term Depression><Long-Term Potentiation><Long-Term Synaptic Depression><Measures><Medial><Methods><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><N Methyl D aspartic Acid><N methyl D aspartate><N-Methyl-D-aspartate><N-Methylaspartate><NIMH><NMDA><National Institute of Mental Health><Nerve Cells><Nerve Unit><Neural Cell><Neural Pathways><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Pathologic><Pathway interactions><Position><Positioning Attribute><Potentiation><Progesterone Receptors><Progestin Receptors><Protocol><Protocols documentation><Protooncogene FOS><Public Health><Publishing><R21 Mechanism><R21 Program><Research><Risk><Role><Side><Slice><Social Behavior><Social Interaction><Social Processes><Societies><Stimulus><Synapses><Synaptic><Synaptic plasticity><Techniques><Testing><Therapeutic><Therapeutic Intervention><Time><Transmission><Violence><Work><amygdaloid nuclear complex><angers><angry><c fos><c-fos Gene><c-fos Proto-Oncogenes><developmental><electrophysiological><ethical><excitatory neuron><experience><experiment><experimental research><experimental study><experiments><exploratory developmental study><exposure to violence><high risk><hypothalamic><improved><innovate><innovation><innovative><insight><intervention therapy><kids><knowledge base><later in life><later life><male><member><model of animal><neural circuit><neural circuitry><neural mechanism><neurocircuitry><neuromechanism><neuronal><neurosurgery><new diagnostics><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><next generation diagnostics><novel><novel diagnostics><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><optogenetics><pathway><power analysis><response><sex><skills><social><social role><sociobehavior><sociobehavioral><synapse><synaptic circuit><synaptic circuitry><transmission process><v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog><violence exposure><violent><violent behavior><youngster><♀><♂>
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ANNA WEXLER

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 30/100
Very recent
Active award
$221,302
FY 2026

Project Title

Assessing the Impact of Mandatory NIH Neuroethics Requirements

Grant Number:

1R21MH141490-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/29/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Human subjects research with novel neural devices raises unique ethical issues, such as post-trial responsibilities, privacy of brain data, and atypical risks such as changes to personality. To manage the discrepancy between research practices and ethics oversight, in 2018 the NIH a...

Research Terms

<Address><Applications Grants><Area><Attitude><BRAIN initiative><Brain><Brain Nervous System><Brain Research through Advancing Innovative Neurotechnologies initiative><Confidential Information><Data><Devices><Educational workshop><Empirical Research><Encephalon><Ensure><Ethical Issues><Ethics><Funding><Future><Glean><Goals><Grant><Grant Proposals><Grant Review><Guidelines><Health Policy><Human Subject Research><Interview><Investigators><Modification><NIH><National Institutes of Health><Nature><Neurosciences><Neurosciences Research><Outcome><Pathway interactions><Peer Review><Perception><Personality><Privacy><Process><Recommendation><Research><Research Personnel><Research Resources><Researchers><Resources><Respondent><Risk><Study Section><Survey Instrument><Surveys><United States National Institutes of Health><Work><Workshop><design><designing><ethical><experience><health care policy><human subject protection><improved><innovate><innovation><innovative><insight><member><neural><neuroethics><neurotechnology><novel><pathway><recruit>
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Anna Huttenlocher

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 30/100
Very recent
Active award
$213,811
FY 2026

Project Title

Engineering CAR-neutrophils as a novel therapeutic modality for Aspergillus fumigatus infection

Grant Number:

1R21AI195318-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Invasive fungal infection by Aspergillus species, most commonly by Aspergillus fumigatus, remains one of the leading causes of mortality in immunocompromised patients undergoing solid organ or HSC transplantation because antifungal agents currently used in clinics are poorly effective in tr...

Research Terms

<3-D><3-Dimensional><3D><A fumigatus><A. fumigatus><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adoptive Transfer><Advanced Development><Affect><Allergic Bronchopulmonary Aspergillosis><Antibodies><Antifungal Therapy><Antigens><Applications Grants><Aspergillosis><Aspergillus><Aspergillus fumigatus><Biology><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood granulocytic cell><Brachydanio rerio><Bronchopulmonary Aspergillosis><CAR T cell therapy><CAR T therapy><CSF3><CSF3 gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cells><Clinic><Collection><Danio rerio><Data><Defense Mechanisms><Development><Drug Interactions><Drug resistance><Drug toxicity><Drugs><Engineering><Fungal Antigens><Fungus Diseases><G-CSF><GCSF><Generations><Genes><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Goals><Grafting Procedure><Grant Proposals><Granular Leukocytes><Granulocytic cell><GvHD><HIV><HSC transplantation><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Homologous Wasting Disease><Human Immunodeficiency Viruses><Hyphae><Immune><Immune mediated therapy><Immunes><Immunity><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunologically Directed Therapy><Immunosuppressed Host><Immunotherapy><Impairment><In Vitro><Infection><Intracellular Communication and Signaling><Knowledge><LAV-HTLV-III><Larva><Life><Lymphadenopathy-Associated Virus><MGC45931><Marrow Neutrophil><Medication><Membrane><Messenger RNA><Methods><Mice><Mice Mammals><Modality><Modeling><Modification><Murine><Mus><Mycoses><Neutropenia><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Organ Transplantation><Organ Transplants><Oxidative Burst><Pancytopenia><Patients><Pharmaceutical Preparations><Phase><Polyenes><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Position><Positioning Attribute><Production><Property><Protocol><Protocols documentation><Recombinant DNA Technology><Respiratory Burst><Risk><Runt Disease><Safety><Signal Transduction><Signal Transduction Systems><Signaling><Site><Solid><T-Cells><T-Lymphocyte><Therapeutic><Therapeutic Fungicides><Toxic effect><Toxicities><Transfusion><Treatment Efficacy><Triazoles><Virus-HIV><Zebra Danio><Zebra Fish><Zebrafish><anti-fungal><anti-fungal agents><anti-fungal drug><biological signal transduction><blood stem cell transplantation><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chimeric antigen receptor><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor T cell therapy><chimeric antigen receptor T therapy><determine efficacy><developmental><drug resistant><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><extracellular><fungal infection><fungal infectious disease treatment><fungicidal><fungicide><fungus><fungus infection><genetically engineered><graft versus host disease><graft vs host disease><graft vs. host disease><granulocyte><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><iPS><iPSC><iPSCs><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunosuppressed patient><improved><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><intervention efficacy><leukocyte oxidative burst><life span><lifespan><mRNA><membrane structure><migration><mortality><mouse model><multidisciplinary><murine model><neutrophil><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><organ allograft><organ graft><organ xenograft><prevent><preventing><progenitor biology><progenitor cell biology><psychological defense mechanism><public health relevance><pulmonary aspergillosis><receptor expression><resistance strain><resistance to Drug><resistant strain><resistant to Drug><response><stem and progenitor biology><stem cell biology><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy><three dimensional><thymus derived lymphocyte><tool><trafficking><trait><weapons>
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Igor I. Slukvin

UNIVERSITY OF WISCONSIN-MADISON, MADISON, WI

Exploratory lead · 30/100
Very recent
Active award
$213,811
FY 2026

Project Title

Engineering CAR-neutrophils as a novel therapeutic modality for Aspergillus fumigatus infection

Grant Number:

1R21AI195318-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Invasive fungal infection by Aspergillus species, most commonly by Aspergillus fumigatus, remains one of the leading causes of mortality in immunocompromised patients undergoing solid organ or HSC transplantation because antifungal agents currently used in clinics are poorly effective in tr...

Research Terms

<3-D><3-Dimensional><3D><A fumigatus><A. fumigatus><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adoptive Transfer><Advanced Development><Affect><Allergic Bronchopulmonary Aspergillosis><Antibodies><Antifungal Therapy><Antigens><Applications Grants><Aspergillosis><Aspergillus><Aspergillus fumigatus><Biology><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood granulocytic cell><Brachydanio rerio><Bronchopulmonary Aspergillosis><CAR T cell therapy><CAR T therapy><CSF3><CSF3 gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell Therapy><Cells><Clinic><Collection><Danio rerio><Data><Defense Mechanisms><Development><Drug Interactions><Drug resistance><Drug toxicity><Drugs><Engineering><Fungal Antigens><Fungus Diseases><G-CSF><GCSF><Generations><Genes><Genetic><Genetic Engineering><Genetic Engineering Biotechnology><Genetic Engineering Molecular Biology><Goals><Grafting Procedure><Grant Proposals><Granular Leukocytes><Granulocytic cell><GvHD><HIV><HSC transplantation><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Homologous Wasting Disease><Human Immunodeficiency Viruses><Hyphae><Immune><Immune mediated therapy><Immunes><Immunity><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunologically Directed Therapy><Immunosuppressed Host><Immunotherapy><Impairment><In Vitro><Infection><Intracellular Communication and Signaling><Knowledge><LAV-HTLV-III><Larva><Life><Lymphadenopathy-Associated Virus><MGC45931><Marrow Neutrophil><Medication><Membrane><Messenger RNA><Methods><Mice><Mice Mammals><Modality><Modeling><Modification><Murine><Mus><Mycoses><Neutropenia><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Organ Transplantation><Organ Transplants><Oxidative Burst><Pancytopenia><Patients><Pharmaceutical Preparations><Phase><Polyenes><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Position><Positioning Attribute><Production><Property><Protocol><Protocols documentation><Recombinant DNA Technology><Respiratory Burst><Risk><Runt Disease><Safety><Signal Transduction><Signal Transduction Systems><Signaling><Site><Solid><T-Cells><T-Lymphocyte><Therapeutic><Therapeutic Fungicides><Toxic effect><Toxicities><Transfusion><Treatment Efficacy><Triazoles><Virus-HIV><Zebra Danio><Zebra Fish><Zebrafish><anti-fungal><anti-fungal agents><anti-fungal drug><biological signal transduction><blood stem cell transplantation><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><chimeric antigen receptor><chimeric antigen receptor (CAR) T cell therapy><chimeric antigen receptor T cell therapy><chimeric antigen receptor T therapy><determine efficacy><developmental><drug resistant><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><extracellular><fungal infection><fungal infectious disease treatment><fungicidal><fungicide><fungus><fungus infection><genetically engineered><graft versus host disease><graft vs host disease><graft vs. host disease><granulocyte><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><iPS><iPSC><iPSCs><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunogen><immunosuppressed patient><improved><in vivo><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><innovate><innovation><innovative><intervention efficacy><leukocyte oxidative burst><life span><lifespan><mRNA><membrane structure><migration><mortality><mouse model><multidisciplinary><murine model><neutrophil><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><organ allograft><organ graft><organ xenograft><prevent><preventing><progenitor biology><progenitor cell biology><psychological defense mechanism><public health relevance><pulmonary aspergillosis><receptor expression><resistance strain><resistance to Drug><resistant strain><resistant to Drug><response><stem and progenitor biology><stem cell biology><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapy efficacy><three dimensional><thymus derived lymphocyte><tool><trafficking><trait><weapons>
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Christopher McGraw

NORTHWESTERN UNIVERSITY AT CHICAGO, CHICAGO, IL

Exploratory lead · 30/100
Very recent
Active award
$200,000
FY 2026

Project Title

High-Throughput in Vivo Discovery of Novel Countermeasures Against Organophosphate-Induced Seizure and Status Epilepticus Using Zebrafish

Grant Number:

5R21NS127345-04

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2022

End Date:

12/31/2026

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Chemical threats are a major public health concern and CounterACT recognizes the need to identify new medical countermeasures (MCMs) that improve the public health response to mass casualty events related to chemical threats. Organophosphate (OP) agents are of particular concern due ...

Research Terms

<Acoustics><Acridine Orange><Address><Animal Model><Animal Models and Related Studies><Anti-epileptic><Apoptotic><Assay><Ativan><Atropine><Bioassay><Biological Assay><Brachydanio rerio><Calcium><Caring><Cell Body><Cells><Chemical Exposure><Chemical Weapons><Chemicals><Chlorpyrifos><Clinical><Clinical Evaluation><Clinical Testing><Complication><Danio rerio><Data><Detection><Disease><Disorder><Dose><Drug Screening><Drugs><Dysfunction><Electrophysiology><Electrophysiology (science)><Event><Exposure to><FDA approved><Fluorescence><Functional disorder><Generalized Epilepsy><Generalized Seizure Disorder><Generalized Status Epilepticus><Genetic><High Throughput Assay><Human><Intoxication><Levetiracetam><Literature><Lorazepam><Maximal Tolerated Dose><Maximally Tolerated Dose><Maximum Tolerated Dose><Measures><Medical><Medication><Memantin><Memantine><Modeling><Modern Man><Molecular><Monitor><Neurophysiology / Electrophysiology><Organophosphates><Paraoxon><Parathion><Pesticides><Pharmaceutical Preparations><Phorate><Phosphostigmine><Physiopathology><Property><Public Health><Research><Sarin><Sedation procedure><Seizures><Soman><Standardization><Startle Reaction><Status Epilepticus><TUNEL Assay><TdT-Mediated dUTP Nick End Labeling Assay><Time><Validation><Visual><Whole Organism><Work><Zebra Danio><Zebra Fish><Zebrafish><acute toxicity><anti-epileptic agents><anti-epileptic drugs><blind><candidate identification><chemical threat><clinical test><develop therapy><dl-Hyoscyamine><drug/agent><electrophysiological><excitotoxic><excitotoxicity><experiment><experimental research><experimental study><experiments><exposed human population><high throughput screening><human exposure><improved><in vivo><intervention development><mass casualty><medical countermeasure><model of animal><nerve agent><novel><pathophysiology><programs><real world application><research clinical testing><response><screening><screenings><sedation><sedative><startle response><tabun><therapeutic candidate><therapy development><treatment development><validations>
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Elizabeth Salmon Heller Murray

TEMPLE UNIV OF THE COMMONWEALTH, PHILADELPHIA, PA

Exploratory lead · 30/100
Very recent
Active award
$198,125
FY 2026

Project Title

Intelligibility and dysphonia in children with vocal fold nodules

Grant Number:

5R21DC021248-03

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Voice disorders occur in 6–17% of children, resulting in dysphonia (i.e., altered vocal quality) which has significant negative health, social, emotional, and educational consequences if left untreated. The most common cause of dysphonia in children is vocal fold nodules (VFN), callus-like growths o...

Research Terms

<0-11 years old><21+ years old><Acoustics><Address><Adult><Adult Human><Affect><Age><Area><Articulation><Auditory><Bone callus><Bony Callus><Boston><Callus><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Clinical><Clinical Trials Design><Communication><Data><Dedications><Development><Disease><Disorder><Dysphonia><Education><Educational aspects><Effectiveness><Emotional><Environment><Evaluation><Foundations><Generalized Growth><Glean><Goals><Grant><Growth><Health><Human><Left><Lesion><Measures><Medical center><Methods><Modern Man><NIDCD><National Institute on Deafness and Other Communication Disorders><Nodule><Outcome><Pattern><Pediatric Hospitals><Perception><Philadelphia><Phonation Disorders><Population><Production><Randomized, Controlled Trials><Research><Sampling><Selection for Treatments><Severities><Speech><Speech Intelligibilities><Speech Intelligibility><System><Testing><Therapeutic><Tissue Growth><Treatment Effectiveness><Treatment Efficacy><Underserved Population><Universities><Vocal Fold><Voice><Voice Disorders><Vulnerable Populations><adulthood><ages><career><child patients><clinical database><critical developmental period><customized therapy><customized treatment><design><designing><developmental><early-career faculty><effective therapy><effective treatment><effectiveness testing><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><innovate><innovation><innovative><intervention efficacy><kids><ontogeny><patient specific therapies><patient specific treatment><pediatric><pediatric patients><programs><psychosocial><randomized control trial><randomized, clinical trials><selection of treatment><social><standard care><standard treatment><tailored medical treatment><tailored therapy><tailored treatment><therapeutic efficacy><therapy efficacy><therapy optimization><therapy selection><treatment optimization><treatment selection><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><unique treatment><vocal cord><voice therapy><vulnerable group><vulnerable individual><vulnerable people><youngster>
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Marina Guizzetti

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Exploratory lead · 30/100
Very recent
Active award
$195,000
FY 2026

Project Title

Rapid protein translation in nucleus accumbens neurons in response to a cocaine-associated cue

Grant Number:

5R21DA060442-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Cues associated with drugs of abuse are powerful triggers of craving and relapse, and increased reactivity to such cues is a core feature of substance use disorder. To understand mechanisms that support cue-induced cocaine craving, we use the incubation of craving model, in which rat...

Research Terms

<Abstinence><Adenosine><Affinity Chromatography><Alcohol Chemical Class><Alcohols><Area><Automobile Driving><Behavior><Behavioral><Cocaine><Cocaine Users><Cocaine withdrawal><Common Rat Strains><Complex><Crystal Meth><Crystal methamphetamine><Cue-induced relapse><Cues><D2 receptor><DRD2 Receptor><Data><Deoxyephedrine><Desoxyephedrine><Dopamine><Dopamine D2 Receptor><Drug user><Drugs><Exhibits><Exploratory/Developmental Grant><Exposure to><Fear><Female><Fright><Future><Genes><Goals><Grant><Hospital Admission><Hospitalization><Human><Hydroxytyramine><Immune Precipitation><Immunoblotting><Immunoprecipitation><Imprisonment><Incubated><Infusion><Infusion procedures><Investigation><Light><Measures><Mediating><Medication><Messenger RNA><Methamphetamine><Methodology><Methods><Methylamphetamine><Modeling><Modern Man><N-Methylamphetamine><Nasal><Nasal Passages Nose><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neural Transmission><Neurocyte><Neuronal Transmission><Neurons><Nicotine><Non-Polyadenylated RNA><Nose><Nucleus Accumbens><Opiates><Opioid><Outcome><PWUD><Pharmaceutical Preparations><Photoradiation><Process><Proteins><Punishment><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><R21 Mechanism><R21 Program><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNA-seq using translating ribosome affinity purification><RNAseq><Rat><Rat Transgene><Rats Mammals><Rattus><Receptor Protein><Relapse><Respiratory System, Nose, Nasal Passages><Rewards><Ribonucleic Acid><Ribosomal Proteins><Ribosomes><Role><Saline><Saline Solution><Self Administered><Self Administration><Substance Use Disorder><Synaptic Transmission><Synaptic plasticity><TRAP RNA sequencing><TRAP RNA-seq><TRAP-seq><Testing><Training><Translating><Translating Ribosome Affinity Purification followed by RNA sequencing><Translating Ribosome Affinity Purification technology followed by RNA sequencing><Translations><Validation><Virus><Western Blotting><Western Immunoblotting><Withdrawal><Work><abused drug><abused drugs><addiction><addictive disorder><affinity purification><axon signaling><axon-glial signaling><axonal signaling><cell type><cocaine craving><cocaine cue><cocaine exposure><cocaine seeking><cocaine self-administration><cocaine use><cocaine-exposed><contingency management><craving><cue reactivity><driving><drug abused><drug craving><drug of abuse><drug/agent><drugs abused><drugs of abuse><experiment><experimental research><experimental study><experiments><exploratory developmental study><exposed to cocaine><exposure to cocaine><glia signaling><glial signaling><incarcerated><incarceration><infusions><insight><mRNA><male><meth><motivated behavior><nerve signaling><neural adaptation><neural signaling><neuroadaptation><neuronal><neuronal signaling><neurotransmission><non-drug><nondrug><novel><people who use drugs><people who use illicit drugs><persons who use drugs><prolonged abstinence><protein blotting><qRTPCR><receptor><response><self-administer cocaine><shRNA><short hairpin RNA><small hairpin RNA><social role><substance use and disorder><sustained abstinence><transcriptome sequencing><transcriptomic sequencing><translating ribosome affinity purification and RNA-sequencing><translating ribosome affinity purification with RNA sequencing><translation><translatome><validations><♀><♂>
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Marina Elizabeth Wolf

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Exploratory lead · 30/100
Very recent
Active award
$195,000
FY 2026

Project Title

Rapid protein translation in nucleus accumbens neurons in response to a cocaine-associated cue

Grant Number:

5R21DA060442-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Cues associated with drugs of abuse are powerful triggers of craving and relapse, and increased reactivity to such cues is a core feature of substance use disorder. To understand mechanisms that support cue-induced cocaine craving, we use the incubation of craving model, in which rat...

Research Terms

<Abstinence><Adenosine><Affinity Chromatography><Alcohol Chemical Class><Alcohols><Area><Automobile Driving><Behavior><Behavioral><Cocaine><Cocaine Users><Cocaine withdrawal><Common Rat Strains><Complex><Crystal Meth><Crystal methamphetamine><Cue-induced relapse><Cues><D2 receptor><DRD2 Receptor><Data><Deoxyephedrine><Desoxyephedrine><Dopamine><Dopamine D2 Receptor><Drug user><Drugs><Exhibits><Exploratory/Developmental Grant><Exposure to><Fear><Female><Fright><Future><Genes><Goals><Grant><Hospital Admission><Hospitalization><Human><Hydroxytyramine><Immune Precipitation><Immunoblotting><Immunoprecipitation><Imprisonment><Incubated><Infusion><Infusion procedures><Investigation><Light><Measures><Mediating><Medication><Messenger RNA><Methamphetamine><Methodology><Methods><Methylamphetamine><Modeling><Modern Man><N-Methylamphetamine><Nasal><Nasal Passages Nose><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neural Transmission><Neurocyte><Neuronal Transmission><Neurons><Nicotine><Non-Polyadenylated RNA><Nose><Nucleus Accumbens><Opiates><Opioid><Outcome><PWUD><Pharmaceutical Preparations><Photoradiation><Process><Proteins><Punishment><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><R21 Mechanism><R21 Program><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNA-seq using translating ribosome affinity purification><RNAseq><Rat><Rat Transgene><Rats Mammals><Rattus><Receptor Protein><Relapse><Respiratory System, Nose, Nasal Passages><Rewards><Ribonucleic Acid><Ribosomal Proteins><Ribosomes><Role><Saline><Saline Solution><Self Administered><Self Administration><Substance Use Disorder><Synaptic Transmission><Synaptic plasticity><TRAP RNA sequencing><TRAP RNA-seq><TRAP-seq><Testing><Training><Translating><Translating Ribosome Affinity Purification followed by RNA sequencing><Translating Ribosome Affinity Purification technology followed by RNA sequencing><Translations><Validation><Virus><Western Blotting><Western Immunoblotting><Withdrawal><Work><abused drug><abused drugs><addiction><addictive disorder><affinity purification><axon signaling><axon-glial signaling><axonal signaling><cell type><cocaine craving><cocaine cue><cocaine exposure><cocaine seeking><cocaine self-administration><cocaine use><cocaine-exposed><contingency management><craving><cue reactivity><driving><drug abused><drug craving><drug of abuse><drug/agent><drugs abused><drugs of abuse><experiment><experimental research><experimental study><experiments><exploratory developmental study><exposed to cocaine><exposure to cocaine><glia signaling><glial signaling><incarcerated><incarceration><infusions><insight><mRNA><male><meth><motivated behavior><nerve signaling><neural adaptation><neural signaling><neuroadaptation><neuronal><neuronal signaling><neurotransmission><non-drug><nondrug><novel><people who use drugs><people who use illicit drugs><persons who use drugs><prolonged abstinence><protein blotting><qRTPCR><receptor><response><self-administer cocaine><shRNA><short hairpin RNA><small hairpin RNA><social role><substance use and disorder><sustained abstinence><transcriptome sequencing><transcriptomic sequencing><translating ribosome affinity purification and RNA-sequencing><translating ribosome affinity purification with RNA sequencing><translation><translatome><validations><♀><♂>
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Elise M Weerts

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 30/100
Very recent
Active award
$194,271
FY 2026

Project Title

Optimizing rodent models of drug discrimination and self-administration of vaporized cannabis extracts for medications development

Grant Number:

1R21DA064845-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Summary The goal of this R21 NIH Exploratory/Developmental Research project is to advance development of rodent models of drug discrimination, drug-seeking and self-administration of vaporized cannabis extract to facilitate future medications development for cannabis use disorder (CUD). There are no...

Research Terms

<4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><9-ene-Tetrahydrocannabinol><Advanced Development><Agonist><Alcohol Chemical Class><Alcohols><Aminalon><Aminalone><Animal Model><Animal Models and Related Studies><Benzodiazepine Compounds><Benzodiazepines><Blood><Blood Plasma><Blood Reticuloendothelial System><CB1><CB1 Receptor><CB1R><CNR1 gene><Cannabinoid Receptor CB1><Cannabinoids><Cannabis><Catheters><Cocaine><Cognitive Discrimination><Common Rat Strains><Complex><D9-tetrahydrocannabinol><Data><Delta-9-Tetrahydrocannabinol><Development><Discrimination><Dose><Drug Delivery><Drug Delivery Systems><Drug Therapy><Drug Utilization><Drugs><Evaluation><Exposure to><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Future><GABA><Goals><Human><IP injection><Inhalation><Inhaling><Intake><Intoxication><Intraperitoneal Injections><Intravenous><Maintenance><Measures><Medication><Modeling><Modern Man><NIH><National Institutes of Health><Nicotine><Opiates><Opioid><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Plasma><Plasma Serum><Prevalence><Procedures><Psychological reinforcement><R-Series Research Projects><R01 Mechanism><R01 Program><Rat><Rats Mammals><Rattus><Receptor Protein><Reinforcement><Reinforcement Schedule><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Reticuloendothelial System, Serum, Plasma><Rodent><Rodent Model><Rodentia><Rodents Mammals><Route><Saimiri><Saimirus><Schedule><Self Administered><Self Administration><Solubility><Squirrel Monkey><Stimulus><THC co-use><THC use><Technology><Terpene Compound><Terpenes><Terpenoids><Testing><Tetrahydrocannabinol><Tetrahydrocannabinol co-use><Tetrahydrocannabinol use><Time><Training><United States National Institutes of Health><Validation><antagonism><antagonist><cannabinoid administration><cannabinoid receptor 1><cannabinoid receptor type 1><cannabinoid type 1><cannabis self-administration><cannabis use><cannabis use disorder><delta(1)-THC><delta(1)-Tetrahydrocannabinol><delta(9)-THC><delta(9)-Tetrahydrocannabinol><developmental><drug discrimination><drug intervention><drug treatment><drug/agent><experience><gamma-Aminobutyric Acid><intraperitoneal><male><marijuana use><marijuana use and disorder><marijuana use disorder><model of animal><neural mechanism><neuromechanism><novel><paired stimuli><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phytocannabinoid><receptor><reinforcer><response><success><synthetic cannabinoid><validations><vapor><vaporization><Δ(1)-THC><Δ(1)-tetrahydrocannabinol><Δ(9)-THC><Δ(9)-tetrahydrocannabinol><Δ-9-tetrahydrocannabinol><Δ9-tetrahydrocannabinol><γ-Aminobutyric Acid><♂>
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YUYING LIANG

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 30/100
Very recent
Active award
$192,500
FY 2026

Project Title

Development of broadly protective Lassa vaccines using the Pichinde virus vector

Grant Number:

1R21AI190751-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/9/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Abstract Lassa virus (LASV) is a rodent-borne enveloped RNA virus within the Arenaviridae family and can cause Lassa fever, a lethal viral hemorrhagic fever (VHF) disease in humans, for which there are no approved vaccines and limited therapeutic options. Lassa fever is endemic in West Africa and, w...

Research Terms

<1-Beta-D-ribofuranosyl-1,2,4-triazolo-3-carboxamide><1-Beta-D-ribofuranosyl-1H-1,2,4-triazole-3-carboxamide><Address><Advanced Development><Africa><Animal Model><Animal Models and Related Studies><Antibodies><Antigen Targeting><Antigen-Presenting Cells><Antigens><Arenaviridae><Arenavirus><Arenavirus group><Attenuated><BSL-4 facility><BSL4 facility><Biology><Cancers><Cell Mediated Immunology><Cell-Mediated Immunity><Cellular Immunity><Cessation of life><Clinical><Clinical Evaluation><Clinical Testing><Common Rat Strains><Communicable Diseases><Data><Death><Dengue><Development><Disease><Disease Outbreaks><Disorder><Dose><Ebola><Endemic Diseases><Engineering><FDA approved><Family><Fatality rate><Frankfurt-Marburg Syndrome Virus><Genome><Glycoproteins><Habitats><Hospital Admission><Hospitalization><Human><Immunity><Immunology><Infection><Infectious Diseases><Infectious Disorder><Innate Immunity><Knowledge><Lassa><Lassa Fever><Lassa disease><Lassa fever virus><Lassa virus><Malignant Neoplasms><Malignant Tumor><Mammarenavirus><Marburg><Marburg virus><Marburg-like Viruses><Marburgvirus><Maryland><Measures><Miscarriage><Modern Man><Mothers><NIAID><National Institute of Allergy and Infectious Disease><Native Immunity><Natural Immunity><Non-Polyadenylated RNA><Non-Specific Immunity><Nonspecific Immunity><Nucleoproteins><ORFs><Open Reading Frames><Orthomarburgvirus><Outbreaks><Patients><Phase><Pichinde><Pichinde virus><Preclinical Testing><Protein Coding Region><RNA><RNA Gene Products><RNA Viruses><Rat><Rats Mammals><Rattus><Recombinants><Research><Ribavirin><Ribonucleic Acid><Ribovirin><Rodent><Rodentia><Rodents Mammals><Safety><Spontaneous abortion><Supportive Therapy><Supportive care><T cell response><T-Cells><T-Lymphocyte><Testing><Therapeutic><Tribavirin><Vaccination acquired immunity><Vaccination induced immunity><Vaccine Design><Vaccine Production><Vaccines><Variant><Variation><Viral><Viral Antigens><Viral Diseases><Viral Hemorrhagic Fevers><Viral Vaccines><Viral Vector><Virus><Virus Diseases><accessory cell><adaptive immunity><arm><attenuate><attenuates><biosafety level 4 facility><burden of disease><burden of illness><clinical test><cross immunity><cross protection><design><designing><developmental><disease burden><evaluate vaccines><fighting><guinea pig model><hemorrhagic fever><human pathogen><immunogen><insight><malignancy><model of animal><neoplasm/cancer><neutralizing antibody><new vaccines><next generation vaccines><novel><novel vaccines><pandemic><pandemic concern><pandemic disease><pandemic potential><pandemic risk><pandemic threat><pathogen><permanent hearing loss><pre-clinical><pre-clinical testing><preclinical><produce vaccines><protective efficacy><research clinical testing><research facility><side effect><therapeutically effective><thymus derived lymphocyte><vaccine acquired immunity><vaccine associated immunity><vaccine candidate><vaccine evaluation><vaccine platform><vaccine screening><vaccine testing><vaccine-induced immunity><vaccine-induced protection><vector><viral infection><virus antigen><virus infection><virus-induced disease>
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JEAN M BIDLACK

UNIVERSITY OF ROCHESTER, ROCHESTER, NY

Exploratory lead · 30/100
Very recent
Active award
$192,500
FY 2026

Project Title

Xylazine Interaction with Opioid Receptors: Binding and Signaling

Grant Number:

5R21DA061044-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

4/30/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary/Abstract This resubmitted R21 proposal is in response to the Notice of Special Interest (NOSI): Xylazine: Understanding Its Use and Consequences, NOT-DA-24-012. The goal of this study is to determine if xylazine and its metabolites act as agonists or positive allosteric modulators (P...

Research Terms

<3'5'-cyclic ester of AMP><3,5 cyclic AMP synthetase><Absence of pain sensation><Absence of sensibility to pain><Actiq><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adenyl Cyclase><Adenylate Cyclase><Adenylyl Cyclase><Adrenergic Agonists><Adrenergic Antagonists><Adrenergic Blockaders><Adrenergic Blockers><Adrenergic Receptor><Adrenergic Receptor Agonist><Adrenergic Receptor Antagonists><Adrenergic Receptor Blockaders><Adrenergic-Blocking Agents><Adrenoceptors><Adrenolytic Agents><Adrenolytic Drugs><Adrenolytics><Adrenomimetics><Affect><Affinity><Agonist><Allosteric Site><Amides><Animals><Anti-Adrenergics><Anti-adrenergic Agents><Antiadrenergic Agents><Antiadrenergics><Arrestin Beta 1><Arrestin Beta 1 Protein><Arrestin β1><Assay><Binding><Bioassay><Biological Assay><CHO Cells><Cell Communication and Signaling><Cell Growth in Number><Cell Line><Cell Multiplication><Cell Proliferation><Cell Signaling><Cell membrane><CellLine><Cellular Proliferation><Chinese Hamster Ovary><Chinese Hamster Ovary Cell><Clonidine><Coleonol><Common Rat Strains><Cyclic AMP><Cytoplasmic Membrane><Data><Dependence><Diacetylmorphine><Diamorphine><Drugs><Duragesic><Dynorphin (1-17)><Dynorphin A><Epinephrine Receptors><FDA approved><Feels no pain><Female><Fentanest><Fentanyl><Fentyl><Forskolin><G-Proteins><GTP-Binding Proteins><GTP-Regulatory Proteins><Goals><Guanine Nucleotide Coupling Protein><Guanine Nucleotide Regulatory Proteins><Heroin><Human><Immunoglobulin Binding Factor><Immunoglobulin binding proteins><Infumorph><Intracellular Communication and Signaling><Kadian><Klofenil><MCF-7><MCF-7 Cell><MCF-7DR><MCF-7WT><MCF7><MCF7 cell><MDA-MB-468><MS Contin><MSir><Measures><Mediating><Medication><Mice><Mice Mammals><Modern Man><Molecular Interaction><Morphia><Morphine><Murine><Mus><Naloxone><Narcan><Narcanti><No sensitivity to pain><Opiate Antagonist><Opiate Receptors><Opiate receptor antagonist><Opiates><Opioid><Opioid Antagonist><Opioid Receptor><Opioid receptor antagonist><Oramorph><Oramorph SR><Paper><Persons><Pharmaceutical Preparations><Phenothiazines><Phentanyl><Physiologic><Physiological><Plasma Membrane><Property><Proteins><Rat><Rats Mammals><Rattus><Receptor Inhibition><Receptor Protein><Receptor Signaling><Reporting><Research><Respiratory Depression><Roxanol><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Skin Tissue><Statex SR><Stimulant><Strains Cell Lines><Street Drugs><Testing><Ventilatory Depression><Weight Gain><Weight Increase><Withdrawal><Xylaxine><Xylazine><adenoreceptor><adenosine 3'5' monophosphate><amputated limb><analgesia><analog><antagonism><antagonist><antinociception><antinociceptive><arrestin 2><arrestin B><beta-arrestin><biological signal transduction><body weight gain><body weight increase><bone><cAMP><cultured cell line><cutaneous tissue><depressed breathing><depression of breathing><drug/agent><experiment><experimental research><experimental study><experiments><fentanyl self-administration><interest><kappa opiate><kappa opioid><kappa opioid receptors><limb amputation><male><mu opioid receptors><necrotic tissue><pharmacologic><plasma protein Z><plasmalemma><positive allosteric modulator><protein Z><protein activation><radioligand><receptor><receptor coupling><recruit><response><sedative><sigma receptors><sigma-1 receptor><sigma-2 receptor><soft tissue><tissue necrosis><wt gain><β-arrestin><κ opiate><κ opioid><κ opioid receptors><κ-OR><κOR><μ opioid receptors><μ-OR><μOR><♀><♂>
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Jennifer C. Lai

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 30/100
Recent
Active award
Career award
$188,743
FY 2026

Project Title

The Impact of Frailty on Liver Transplant Outcomes in Older Adults with Hepatocellular Carcinoma

Grant Number:

5K24AG080021-04

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/15/2023

End Date:

12/31/2027

Project Abstract

PROJECT ABSTRACT I am a transplant hepatologist on faculty as Associate Professor of Medicine in the Division of Gastroenterology & Hepatology, who has developed a nationally recognized clinical research program focused on the application of aging research and geriatric principles of care to the man...

Research Terms

<AD risk><AD risk factor><Acceleration><Accounting><Adipose tissue><Age><Aging><Alpha-1-Fetoprotein><Alpha-Fetoglobulin><Alzheimer risk factor><Alzheimer's disease risk><Award><Cancer Cause><Cancer Etiology><Caring><Categories><Cessation of life><Chronic><Chronology><Cirrhosis><Classification><Clinical><Clinical Research><Clinical Study><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Curriculum><Data><Data Bases><Data Set><Databases><Death><Decision Making><Dedications><Discipline><Disease><Disorder><Disturbance in cognition><Dropout><Educational Curriculum><Elderly><Eligibility><Eligibility Determination><Endowment><Ensure><Exclusion><Faculty><Fatty Tissue><Fetuins><Financial Support><Funding><Gastroenterology><Geriatrics><Grafting Procedure><Habilitation><Health><Hepatic Disorder><Hepatic Failure><Hepatic Transplantation><Hepatocarcinoma><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatology><Hepatoma><Hospital Admission><Hospitalization><Impaired cognition><Improve Access><Industry><Infrastructure><Intervention><Intuition><Investigators><Knowledge><Laboratories><Leadership><Liver><Liver Cells Carcinoma><Liver Failure><Liver Grafting><Liver Transplant><Liver diseases><Living Donor Liver Transplantation><MRI Scans><Magnetic Resonance Imaging Scan><Measurement><Medical><Medicine><Mentors><Mentorship><Modeling><Muscle><Muscle Tissue><Natural History><Older Population><Oncology><Oncology Cancer><Operative Procedures><Operative Surgical Procedures><Organ><Organ Transplantation><Organ Transplants><Outcome><Pathway interactions><Patients><Pattern><Perioperative><Physiologic><Physiological><Population><Position><Positioning Attribute><Primary Malignant Neoplasm of Liver><Primary carcinoma of the liver cells><Primary liver cancer><Protocol Screening><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><Recurrence><Recurrent><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Research Support><Researchers><Resources><Risk><Risk Assessment><Risk Factors><Role><Severity of illness><Skeletal Muscle><Solid><Stage at Diagnosis><Standardization><Structure><Surgical><Surgical Interventions><Surgical Procedure><Surgical Profession><Surgical Specialties><Systematics><Testing><Time><Training><Transplant Recipients><Transplantation><Tumor Burden><Tumor Load><Voluntary Muscle><Waiting Lists><Work><abdominal CT><abdominal computed tomography><adipose><advanced age><age associated effects><age effect><age related effects><ages><aging associated><aging demography><aging effect><aging related><alzheimer risk><associate faculty><associate professor><cancer progression><career><career development><chronic hepatic disease><chronic hepatic disorder><chronic liver disease><chronic liver disorder><cirrhotic><co-morbid><co-morbidity><cognitive dysfunction><cognitive loss><cohort><comorbidity><curative intervention><curative therapeutic><curative therapy><curative treatments><data base><deceased donor><deceased organ donors><demographics><disability><disease severity><experience><financial aid><financial assistance><fitness><frailty><functional status><geriatric><geriatric medicine><hepatic body system><hepatic disease><hepatic organ system><hepatopathy><impact of age><improved><indexing><influence of age><interest><intuitive><lesson plans><liver carcinoma><liver disorder><liver function><liver transplantation><mid-career faculty><midcareer faculty><mortality><muscle bulk><muscle form><muscle mass><muscular><neoplasm progression><neoplastic progression><next generation><novel><old age><older adult><older adulthood><older groups><older individuals><older person><organ allograft><organ graft><organ xenograft><pathway><patient centered><patient oriented><patient oriented research><patient oriented study><post-transplant><post-transplantation><posthumous donors><posthumous organ donor><posttransplant><posttransplantation><pro-aging><progeronic><prognostic><programs><promote aging><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senior citizen><skill acquisition><skill development><skills><social role><surgery><surgery specialty><transplant><transplant centers><transplant patient><tumor><tumor progression><waitlist><white adipose tissue><yellow adipose tissue><α-Fetoproteins>
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Omer Oralkan

NORTH CAROLINA STATE UNIVERSITY RALEIGH, RALEIGH, NC

Exploratory lead · 30/100
Very recent
Active award
$183,122
FY 2026

Project Title

Duplex dual-frequency CMUT array for acoustic angiography

Grant Number:

5R21EB037351-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: In this project we propose to develop and validate new ultrasound hardware technologies for high-contrast, high- resolution microvascular imaging to detect abnormalities in vascular morphology which can be biomarkers for a variety of disease ranging from cancer to dementia. Computed...

Research Terms

<Acoustics><Amentia><Amplifiers><Angiogram><Angiography><Animal Model><Animal Models and Related Studies><Animals><Apoplexy><Area><Arteries><Artifacts><Biological Markers><Blood Vessel Imaging><Blood Vessels><Body Tissues><Brain Vascular Accident><CAT scan><CT X Ray><CT Xray><CT imaging><CT scan><Cancers><Cell Communication and Signaling><Cell Signaling><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Clinical><Collaborations><Complex><Computed Tomography><Contrast Agent><Contrast Drugs><Contrast Media><Custom><Dementia><Development><Devices><Diagnostic><Disease><Disorder><Doctor of Philosophy><Echography><Echotomography><Electronics><Elements><Equipment><Exploratory/Developmental Grant><Frequencies><Goals><Image><Imaging technology><Intracellular Communication and Signaling><Leanness><Lobe><MRI Angiography><Magnetic Resonance Angiography><Malignant Neoplasms><Malignant Tumor><Mechanics><Medical Ultrasound><Microbubbles><Microfabrication><Microscopy><Modeling><Monitor><Morphologic artifacts><Morphology><Noise><Pathology><Performance><Ph.D.><PhD><Physiologic pulse><Position><Positioning Attribute><Process><Pulse><R21 Mechanism><R21 Program><Radiopaque Media><Research><Resolution><Scanning><Signal Transduction><Signal Transduction Systems><Signaling><Stroke><Structure><System><Techniques><Technology><Thinness><Tissues><Tomodensitometry><Transducers><Transmission><Ultrasonic><Ultrasonic Imaging><Ultrasonic Transducer><Ultrasonics><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><Ultrasound transducer><Vascular System><Veins><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><angiographic imaging><bio-markers><biologic marker><biological signal transduction><biomarker><brain attack><catscan><cerebral vascular accident><cerebrovascular accident><clinical translation><clinically translatable><computed axial tomography><computer tomography><computerized axial tomography><computerized tomography><contrast enhanced><contrast imaging><customs><design><designing><developmental><diagnostic ultrasound><digital><electronic><electronic device><experience><exploratory developmental study><fabrication><high resolution imaging><imaging><imaging approach><imaging based approach><imaging in vivo><imaging probe><improved><in vivo><in vivo imaging><indexing><innovate><innovation><innovative><lithography><lobes><malignancy><mechanic><mechanical><model of animal><neoplasm/cancer><non-contrast CT><noncontrast CT><noncontrast computed tomography><novel><operation><operations><prototype><resolutions><sonogram><sonography><sound measurement><stroked><strokes><transmission process><ultrasound><ultrasound imaging><ultrasound scanning><vascular><vascular imaging><vasculature Imaging><voltage>
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RAMYA KUMAR

COLORADO SCHOOL OF MINES, GOLDEN, CO

Exploratory lead · 30/100
Very recent
Active award
$182,581
FY 2026

Project Title

Machine-guided design of chaperone-mimetic polymeric carriers for ribonucleoprotein delivery

Grant Number:

5R21EB036183-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY In this Trailblazer R21, our interdisciplinary team [polymers, machine learning (ML), and hematopoietic stem and progenitor cells (HSPCs)] will innovate ML-guided polymer discovery pipelines for intracellular delivery of ribonucleoproteins (RNPs). Chaperone-mimetic polymers develope...

Research Terms

<Address><Affinity><Africa><Architecture><Asia><Back><Binding><Blind Spots><Blood Precursor Cell><Cell Body><Cell Nucleus><Cell model><Cells><Cellular model><Chaperone><Charge><Clinical><Complex><Consumption><Cytosol><DNA Sequence><DNA delivery><DNA editor><Data><Data Set><Dimensions><Dorsum><Dose><Drugs><Electroporation><Endosomes><Engineering><Engineering / Architecture><Engraftment><Erythroid Precursor Cells><Erythroid Progenitor Cells><Erythroid Stem Cells><Erythropoietic Progenitor Cells><Erythropoietic Stem Cells><Explosion><Financial Hardship><Goals><H-bond><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Hemoglobinopathies><Human><Hydrogen Bonding><Hydrophobicity><Lead><Length><Libraries><Machine Learning><Macrophage><Mediating><Medication><Messenger RNA><Modeling><Modern Man><Molecular Chaperones><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Mφ><Non-Polyadenylated RNA><Nucleus><Outcome><Patients><Pb element><Peptides><Pharmaceutical Preparations><Polymers><Population><Probiotics><Process><Progenitor Cell Engraftment><Proteins><Quality Control><RNA><RNA Gene Products><Receptosomes><Recommendation><Retinal blind spot><Ribonucleic Acid><Ribonucleoproteins><Safety><Sampling><Site><Sorting><Specificity><Speed><Structure><T-Cells><T-Lymphocyte><Temperature><Testing><Therapeutic><Therapeutic Gene Editing><Training><Transmission><Treatment Cost><Umbilical Cord><Umbilical cord structure><Work><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><cellular targeting><combinatorial><conformation><conformational><conformational state><conformationally><conformations><cost><deliver DNA><design><designing><drug/agent><economic hardship><economic strain><electroporative delivery><erythroid progenitor><erythroid-committed progenitors><experiment><experimental research><experimental study><experiments><financial adversity><financial burden><financial distress><financial insecurity><financial instability><financial strain><financial stress><financial worry><flexibility><flexible><gene editor><gene electrotransfer><gene-editing therapy><genome editing><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genome editor><genomic editing><heavy metal Pb><heavy metal lead><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><heuristics><improved><in vivo engraftment><innovate><innovation><innovative><insight><large data sets><large datasets><learning activity><learning method><learning strategies><learning strategy><lipid based nanoparticle><lipid nanoparticle><mRNA><machine based learning><machine learning based framework><machine learning framework><manufacture><melting><mimetics><miniaturize><miniaturized><multipotency><multipotent><nano polymer><nanocarrier><nanopolymer><nanovessel><polymer><polymeric><polypeptide><prevent><preventing><screening><screenings><stem cell engraftment><success><therapeutic editing><therapeutic genome editing><thymus derived lymphocyte><tool><transfer learning><transmission process>
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Mahmut Karakaya

KENNESAW STATE UNIVERSITY, KENNESAW, GA

Exploratory lead · 30/100
Very recent
Active award
$151,440
FY 2026

Project Title

Smartphone-based Retinal Imaging for Diabetic Retinopathy Detection in Egypt

Grant Number:

5R21EY037104-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary: Diabetes affects 537 million adults globally in 2021, with 75% residing in low- and middle-income countries (LMICs). Diabetic retinopathy (DR) is a common complication of diabetes and manifests as retinal vein bleeding. Almost 10% of people with diabetes can progress to vision threa...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Architecture><Attention><Bleeding><Blindness><Caring><Case Study><Case-Base Studies><Cell Phone><Cellular Phone><Cellular Telephone><Central Retinal Vein><Classification><Clinic><Collaborations><Complications of Diabetes Mellitus><Darkness><Decision Making><Detection><Development><Devices><Diabetes Complications><Diabetes Mellitus><Diabetes-Related Complications><Diabetic Complications><Diabetic Retinopathy><Diagnosis><Early Diagnosis><Egypt><Engineering / Architecture><Evaluation><Eye><Eye Exam><Eye Examination><Eye diseases><Eyeball><Fundus photography><Goals><Health><Health Care Facility><Health Care Professional><Health Care Systems><Health Facilities><Health Professional><Hemorrhage><Human><Image><Image Analyses><Image Analysis><Image Enhancement><Imaging Device><Imaging Instrument><Imaging Tool><International><Intuition><Knowledge><LMIC><Label><Light><Localized Lesion><Location><Machine Learning><Maps><Marketing><Methods><Mobile Phones><Modeling><Modern Man><Ophthalmologist><Patients><Performance><Persons><Pharmacies><Pharmacy facility><Phase><Photoradiation><Population><Prevalence><Principal Investigator><Provider><Research><Retina><Retinal Vein><Sight><Source><Structure of central vein of the retina><Students><Symptoms><System><Systematics><Testing><Texture><Training><Vision><Work><adulthood><automated algorithm><automatic algorithm><blood loss><care facilities><case report><clinical practice><collaborative approach><contrast imaging><cost><cost effective><data fusion><deep learning><deep learning algorithm><deep learning based model><deep learning method><deep learning model><deep learning strategy><design><designing><developmental><diabetes><diabetic><early detection><effective therapy><effective treatment><effectiveness study><eye disorder><eye fundus photography><fundus camera><high risk><iPhone><image evaluation><image interpretation><imaging><imaging system><improved><innovate><innovation><innovative><insight><interest><intuitive><lens><lenses><low and middle-income countries><machine based learning><multiple data sets><multiple datasets><network models><novel><ocular disease><ocular disorder><ophthalmic examination><ophthalmopathy><portability><prevent><preventing><programs><retinal imaging><screening><screenings><smart phone><smartphone><trustworthiness><under served area><under served geographic area><under served location><under served region><underserved area><underserved geographic area><underserved location><underserved region><urban area><urban location><urban region><validation studies><vision loss><visual function><visual loss>
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Prasun K Datta

TULANE UNIVERSITY OF LOUISIANA, NEW ORLEANS, LA

Exploratory lead · 30/100
Very recent
Active award
$44,984
FY 2026

Project Title

Development of a Rhesus Macaque Model of Persistent Oral HPV and HIV Co-infection to Study Oropharyngeal Cancer Induction

Grant Number:

3R21DE033875-02S1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/31/2026

End Date:

4/14/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY (FROM ORIGINAL APPLICATION) Human papillomavirus (HPV)-driven oropharyngeal squamous cell cancer (OPSCC) has been rising in incidence in the US and worldwide over the last four decades, particularly among young men. People with human immunodeficiency virus (HIV) have an increased HPV...

Research Terms

<AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Animal Model><Animal Models and Related Studies><Animals><Assay><Autopsy><Bioassay><Biological><Biological Assay><Blood Plasma><Body Tissues><Cancer Induction><Cancers><Cell Body><Cells><Cervical><Chemotactic Cytokines><DNA><Deoxyribonucleic Acid><Development><Diagnosis><Disease><Disease Progression><Disorder><Epidermoid Cell Cancer><Female><Follow-Up Studies><HIV><HIV Seronegativities><HIV Seronegativity><HIV individuals><HIV infected individuals><HIV infected persons><HIV negative><HIV people><HIV positive individuals><HIV positive people><HPV><HPV 16><HPV infection><HPV-16><HPV16><HTLV-III Seronegativities><HTLV-III Seronegativity><Histologic><Histologically><Homologous Chemotactic Cytokines><Human><Human Immunodeficiency Viruses><Human Papilloma Virus><Human Papillomavirus><Human papilloma virus infection><Human papilloma virus type 16><Human papillomavirus 16><Human papillomavirus infection><Human papillomavirus type 16><Immunoassay><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Immunology><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Incidence><Individual><Infection><Infectious Human Wart Virus><Intercrines><LAV-HTLV-III><Lesion><Lymphadenopathy-Associated Virus><M mulatta><M. mulatta><Macaca mulatta><Macaca rhesus><Malignant Epidermoid Cell Neoplasm><Malignant Epidermoid Cell Tumor><Malignant Neoplasms><Malignant Oropharyngeal Neoplasm><Malignant Oropharyngeal Tumor><Malignant Squamous Cell Neoplasm><Malignant Squamous Cell Tumor><Malignant Tumor><Measures><Modeling><Modern Man><NHP models><Neoplasms><Oncogenesis><Oral><Oropharnyx Cancers><Oropharyngeal><Oropharyngeal Cancer><Oropharyngeal Carcinoma><Oropharyngeal Epidermoid Carcinoma><Oropharyngeal Squamous Cell Carcinoma><Oropharynx><Oropharynx Cancer><Oropharynx Carcinoma><Oropharynxs><PLWH><PWH><Palatine Tonsil><Papilloma Viruses><Papillomaviridae><Papillomavirus><Pathogenesis><Pathway interactions><Plasma><Plasma Serum><Play><Public Health><Reticuloendothelial System, Serum, Plasma><Rhesus Macaque><Rhesus Monkey><Role><SIS cytokines><SIV><Saliva><Simian Immunodeficiency Viruses><Site><Soft Palate><Squamous Cell Cancers><Time><Tissues><Velum Palatinum><Viral Burden><Viral Diseases><Viral Load><Viral Load result><Viral Shedding><Virion><Virus><Virus Diseases><Virus Particle><Virus Shedding><Virus-HIV><Work><biologic><cancer risk><carcinogenesis><carcinogenicity><chemoattractant cytokine><chemokine><co-infection><coinfection><cytokine><developmental><follow-up research study><follow-up survey><human papilloma virus 16><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressed><immunosuppressive activity><immunosuppressive function><immunosuppressive response><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infection mouth><innovate><innovation><innovative><male><malignancy><malignant oropharynx neoplasm><malignant oropharynx tumor><model of animal><necropsy><neoplasia><neoplasm/cancer><neoplastic><neoplastic growth><non-human primate><nonhuman primate><nonhuman primate models><oral HIV><oral HPV><oral HPV infection><oral human papilloma virus infection><oral human papillomavirus><oral human papillomavirus infection><oral infection><oral infectious><oral papillomavirus infection><oral pharyngeal><oropharynx epidermoid carcinoma><oropharynx squamous cell carcinoma><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><postmortem><potential biological marker><potential biomarker><precancer><precancerous><premalignant><public health relevance><social role><study with follow-up><synergism><time interval><tongue base><tongue root><tumor><tumorigenesis><type 16 Human papilloma virus><type 16 Human papillomavirus><viral DNA><viral infection><virus DNA><virus infection><virus-induced disease><wart virus><young man><young men><♀><♂>
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VICKI L TRAINA-DORGE

TULANE UNIVERSITY OF LOUISIANA, NEW ORLEANS, LA

Exploratory lead · 30/100
Very recent
Active award
$44,984
FY 2026

Project Title

Development of a Rhesus Macaque Model of Persistent Oral HPV and HIV Co-infection to Study Oropharyngeal Cancer Induction

Grant Number:

3R21DE033875-02S1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/31/2026

End Date:

4/14/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY (FROM ORIGINAL APPLICATION) Human papillomavirus (HPV)-driven oropharyngeal squamous cell cancer (OPSCC) has been rising in incidence in the US and worldwide over the last four decades, particularly among young men. People with human immunodeficiency virus (HIV) have an increased HPV...

Research Terms

<AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Animal Model><Animal Models and Related Studies><Animals><Assay><Autopsy><Bioassay><Biological><Biological Assay><Blood Plasma><Body Tissues><Cancer Induction><Cancers><Cell Body><Cells><Cervical><Chemotactic Cytokines><DNA><Deoxyribonucleic Acid><Development><Diagnosis><Disease><Disease Progression><Disorder><Epidermoid Cell Cancer><Female><Follow-Up Studies><HIV><HIV Seronegativities><HIV Seronegativity><HIV individuals><HIV infected individuals><HIV infected persons><HIV negative><HIV people><HIV positive individuals><HIV positive people><HPV><HPV 16><HPV infection><HPV-16><HPV16><HTLV-III Seronegativities><HTLV-III Seronegativity><Histologic><Histologically><Homologous Chemotactic Cytokines><Human><Human Immunodeficiency Viruses><Human Papilloma Virus><Human Papillomavirus><Human papilloma virus infection><Human papilloma virus type 16><Human papillomavirus 16><Human papillomavirus infection><Human papillomavirus type 16><Immunoassay><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Immunology><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Incidence><Individual><Infection><Infectious Human Wart Virus><Intercrines><LAV-HTLV-III><Lesion><Lymphadenopathy-Associated Virus><M mulatta><M. mulatta><Macaca mulatta><Macaca rhesus><Malignant Epidermoid Cell Neoplasm><Malignant Epidermoid Cell Tumor><Malignant Neoplasms><Malignant Oropharyngeal Neoplasm><Malignant Oropharyngeal Tumor><Malignant Squamous Cell Neoplasm><Malignant Squamous Cell Tumor><Malignant Tumor><Measures><Modeling><Modern Man><NHP models><Neoplasms><Oncogenesis><Oral><Oropharnyx Cancers><Oropharyngeal><Oropharyngeal Cancer><Oropharyngeal Carcinoma><Oropharyngeal Epidermoid Carcinoma><Oropharyngeal Squamous Cell Carcinoma><Oropharynx><Oropharynx Cancer><Oropharynx Carcinoma><Oropharynxs><PLWH><PWH><Palatine Tonsil><Papilloma Viruses><Papillomaviridae><Papillomavirus><Pathogenesis><Pathway interactions><Plasma><Plasma Serum><Play><Public Health><Reticuloendothelial System, Serum, Plasma><Rhesus Macaque><Rhesus Monkey><Role><SIS cytokines><SIV><Saliva><Simian Immunodeficiency Viruses><Site><Soft Palate><Squamous Cell Cancers><Time><Tissues><Velum Palatinum><Viral Burden><Viral Diseases><Viral Load><Viral Load result><Viral Shedding><Virion><Virus><Virus Diseases><Virus Particle><Virus Shedding><Virus-HIV><Work><biologic><cancer risk><carcinogenesis><carcinogenicity><chemoattractant cytokine><chemokine><co-infection><coinfection><cytokine><developmental><follow-up research study><follow-up survey><human papilloma virus 16><immune suppression><immune suppressive activity><immune suppressive function><immunosuppressed><immunosuppressive activity><immunosuppressive function><immunosuppressive response><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infection mouth><innovate><innovation><innovative><male><malignancy><malignant oropharynx neoplasm><malignant oropharynx tumor><model of animal><necropsy><neoplasia><neoplasm/cancer><neoplastic><neoplastic growth><non-human primate><nonhuman primate><nonhuman primate models><oral HIV><oral HPV><oral HPV infection><oral human papilloma virus infection><oral human papillomavirus><oral human papillomavirus infection><oral infection><oral infectious><oral papillomavirus infection><oral pharyngeal><oropharynx epidermoid carcinoma><oropharynx squamous cell carcinoma><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><postmortem><potential biological marker><potential biomarker><precancer><precancerous><premalignant><public health relevance><social role><study with follow-up><synergism><time interval><tongue base><tongue root><tumor><tumorigenesis><type 16 Human papilloma virus><type 16 Human papillomavirus><viral DNA><viral infection><virus DNA><virus infection><virus-induced disease><wart virus><young man><young men><♀><♂>
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Mahmut Karakaya

KENNESAW STATE UNIVERSITY, KENNESAW, GA

Exploratory lead · 30/100
Very recent
Active award
$19,440
FY 2026

Project Title

Smartphone-based Retinal Imaging for Diabetic Retinopathy Detection in Egypt

Grant Number:

3R21EY037104-02S1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary: Diabetes affects 537 million adults globally in 2021, with 75% residing in low- and middle-income countries (LMICs). Diabetic retinopathy (DR) is a common complication of diabetes and manifests as retinal vein bleeding. Almost 10% of people with diabetes can progress to vision threa...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Architecture><Attention><Bleeding><Blindness><Caring><Case Study><Case-Base Studies><Cell Phone><Cellular Phone><Cellular Telephone><Central Retinal Vein><Classification><Clinic><Collaborations><Complications of Diabetes Mellitus><Darkness><Decision Making><Detection><Development><Devices><Diabetes Complications><Diabetes Mellitus><Diabetes-Related Complications><Diabetic Complications><Diabetic Retinopathy><Diagnosis><Early Diagnosis><Egypt><Engineering / Architecture><Evaluation><Eye><Eye Exam><Eye Examination><Eye diseases><Eyeball><Fundus photography><Goals><Health><Health Care Facility><Health Care Professional><Health Care Systems><Health Facilities><Health Professional><Hemorrhage><Human><Image><Image Analyses><Image Analysis><Image Enhancement><Imaging Device><Imaging Instrument><Imaging Tool><International><Intuition><Knowledge><LMIC><Label><Light><Localized Lesion><Location><Machine Learning><Maps><Marketing><Methods><Mobile Phones><Modeling><Modern Man><Ophthalmologist><Patients><Performance><Persons><Pharmacies><Pharmacy facility><Phase><Photoradiation><Population><Prevalence><Principal Investigator><Provider><Research><Retina><Retinal Vein><Sight><Source><Structure of central vein of the retina><Students><Symptoms><System><Systematics><Testing><Texture><Training><Vision><Work><adulthood><automated algorithm><automatic algorithm><blood loss><care facilities><case report><clinical practice><collaborative approach><contrast imaging><cost><cost effective><data fusion><deep learning><deep learning algorithm><deep learning based model><deep learning method><deep learning model><deep learning strategy><design><designing><developmental><diabetes><diabetic><early detection><effective therapy><effective treatment><effectiveness study><eye disorder><eye fundus photography><fundus camera><high risk><iPhone><image evaluation><image interpretation><imaging><imaging system><improved><innovate><innovation><innovative><insight><interest><intuitive><lens><lenses><low and middle-income countries><machine based learning><multiple data sets><multiple datasets><network models><novel><ocular disease><ocular disorder><ophthalmic examination><ophthalmopathy><portability><prevent><preventing><programs><retinal imaging><screening><screenings><smart phone><smartphone><trustworthiness><under served area><under served geographic area><under served location><under served region><underserved area><underserved geographic area><underserved location><underserved region><urban area><urban location><urban region><validation studies><vision loss><visual function><visual loss>
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MATTHEW L MACIEJEWSKI

DURHAM VA MEDICAL CENTER, DURHAM, NC

Exploratory lead · 30/100
Very recent
Active award
$0
FY 2026

Project Title

HSR&D Senior Research Career Scientist Award

Grant Number:

5IK6HX003157-07

Activity Code:

IK6

Mechanism:

Other

Agency:

VA

Start Date:

4/1/2020

End Date:

7/31/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

This proposed Senior Research Career Scientist (SRS) award is to support the activities of Dr. Matthew Maciejewski, a health economist, Research Career Scientist and an established Department of Veterans Affairs (VA) Health Services Research and Development (HSR&D) investigator, allowing him expand ...

Research Terms

<AHCPR><AHRQ><Accident and Emergency department><Address><Advisory Committees><Agency for Health Care Policy and Research><Agency for Healthcare Research and Quality><Ambulatory Care Facilities><Appointment><Award><Big Data><BigData><Body Weight Changes><Body Weight decreased><Caring><Chronic><Cities><Clinical Data><Collaborations><Communities><Community Developments><Comparative Effectiveness Research><Competence><Complex><Contracting Opportunities><Contracts><Data><Development and Research><Drugs><Electronic Health Record><Emergency Department><Emergency room><Environment><Evaluation><Expenditure><Faculty><Freedom><Funding><Goals><Grant><Grant Review><Health><Health Care><Health Services><Health Services Evaluation><Health Services Research><Health system><High Prevalence><Hospital Admission><Hospitalization><International><Investigator-Initiated Research><Investigators><Leadership><Liberty><Literature><Measurement><Medical Care Research><Medication><Mental Health><Mental Hygiene><Mentors><Methodology><Methods><Mission><Modeling><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Obesity><Operative Procedures><Operative Surgical Procedures><Outcome><Outpatient Clinics><Overweight><Patient Care><Patient Care Delivery><Patients><Pharmaceutical Preparations><Play><Policies><Population><Position><Positioning Attribute><Prevalence><Primary Care><Principal Investigator><Productivity><Proxy><Psychological Health><QOC><Quality of Care><Quasi-experiment><Quasi-experimental analysis><Quasi-experimental approach><Quasi-experimental design><Quasi-experimental methods><Quasi-experimental research><Quasi-experimental study><Quasi-experimental technique><R & D><R&D><Research><Research Activity><Research Personnel><Research Resources><Research Support><Researchers><Resources><Risk><Role><Scientist><Services><Sodium Chloride><Surgical><Surgical Interventions><Surgical Procedure><System><Task Forces><Training><United States Agency for Health Care Policy and Research><United States Agency for Healthcare Research and Quality><United States Department of Veterans Affairs><United States Veterans Administration><Veterans><Veterans Administration><Veterans Affairs><Veterans Health Administration><Veterans Health Affairs><Weight Change><Weight Loss><Weight Reduction><Weight maintenance regimen><Work><adiposity><advisory team><bariatric surgery><body weight loss><cardiometabolic><cardiometabolism><care for patients><care fragmentation><care of patients><career><career development><caring for patients><clinical predictors><cohort><comparative effectiveness study><copayment><corpulence><cost><design><designing><drug/agent><economic outcome><editorial><effective care management><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><evidence base><experience><gastric banding><gastric bypass surgery><high risk><implantable gastric stimulation banding><improved><insight><interest><learning activity><learning method><learning strategies><learning strategy><meeting><meetings><member><military veteran><multimorbidity><multiple chronic conditions><next generation><obesity management><obesity risk><obesity surgery><population based><primary care patient><programs><research and development><research study><risk for obesity><risk of obesity><salt><service learning><service-based learning><services research><social><social role><statistics><stomach stapling><surgery><veteran population><weight control><weight loss surgery><weight management><wt-loss>
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Mihir R Atreya

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

Exploratory lead · 28/100
Above-average budget
Active award
$705,050
FY 2025

Project Title

Leveraging multi-omics to maximize the scientific value of pediatric sepsis biorepository and advance patient endotyping

Grant Number:

4R33GM151703-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/5/2023

End Date:

6/30/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Leveraging multi-omics to maximize the scientific value of pediatric sepsis biorepository and advance patient endotyping. PROJECT SUMMARY: Sepsis is major pediatric health problem and kills more children than cancer in the U.S each year. Primarily driven by a dysfunctional host response to an infec...

Research Terms

<0-11 years old><Address><Affect><Antibiotic Agents><Antibiotic Drugs><Antibiotics><BeadChip><Bioinformatics><Biological><Biology><Blood Sample><Blood specimen><Cancers><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Data><Clinical Trials><Collection><Communities><CpG Islands><CpG-Rich Islands><Critical Illness><Critically Ill><Critically ill children><DNA><DNA Methylation><DNA methylation profiling><Data><Data Bases><Data Set><Databases><Deoxyribonucleic Acid><Derivation><Derivation procedure><Development><Dimensions><Disease><Disorder><Drugs><Dysfunction><Electronic Health Record><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equity><Evolution><Factor Analyses><Factor Analysis><Feasibility Studies><Foundations><Functional disorder><Funding><Future><Gene Action Regulation><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic Transcription><Health><Human><Immune response><Infection><Investigators><Knowledge><Laboratories><Life><Link><Malignant Neoplasms><Malignant Tumor><Medication><Messenger RNA><Methodology><Methods><Methyl-Seq><MethylSeq><Methylation><Methylation sequencing><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Morbidity><Morbidity - disease rate><NIGMS><National Institute of General Medical Sciences><Nature><Non-Polyadenylated RNA><Organ><Outcome><Pathway interactions><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Pharmaceutical Preparations><Phase><Phased Innovation Awards><Physiopathology><Precision therapeutics><Process><Quality Control><R21/R33 Mechanism><R21/R33 Program><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Reporting><Research><Research Personnel><Research Specimen><Researchers><Ribonucleic Acid><Role><Sampling><Scientific Advances and Accomplishments><Sepsis><Septic Shock><Series><Specimen><Subgroup><Testing><Time><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Validation><Whole Blood><analyze gene expression><antisepsis treatment><bead chip><biobank><biologic><biological heterogeneity><biorepository><care for patients><care of patients><caring for patients><child patients><children with sepsis><clinical relevance><clinical significance><clinically relevant><clinically significant><cohort><critically ill child><data base><data integration><depository><developmental><disease subgroups><disease subtype><disorder subtype><drug/agent><efficacious therapy><efficacious treatment><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><epigenetically><epigenome><epigenomics><gene classifier><gene expression analysis><gene expression assay><gene regulatory network><genetic classifier><genomic classifier><global gene expression><global transcription profile><host response><immune system response><immunoresponse><improved><individuals with sepsis><kids><mRNA><malignancy><methylome><methylomics><mortality><multiomics><multiple omics><neoplasm/cancer><novel><panomics><pathophysiology><pathway><patient oriented outcomes><patient response><patient specific response><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><patients with sepsis><pediatric><pediatric patients><pediatric sepsis><pediatric septic><people with sepsis><performance tests><power analysis><precision medicine><precision therapies><precision treatment><precision-based medicine><prevent><preventing><public health emergency><repository><response to therapy><response to treatment><responsive patient><scale up><scientific accomplishments><scientific advances><sepsis care><sepsis groups><sepsis in children><sepsis interventions><sepsis management><sepsis patients><sepsis population><sepsis subjects><sepsis therapeutics><sepsis therapy><sepsis treatment><septic children><septic group><septic individuals><septic patients><septic people><septic population><septic subject><septic therapy><septic treatment><social role><subjects with sepsis><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic response><therapy response><transcriptional profiling><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><treat sepsis><treatment response><treatment responsiveness><validations><youngster>
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Rishikesan Kamaleswaran

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

Exploratory lead · 28/100
Above-average budget
Active award
$705,050
FY 2025

Project Title

Leveraging multi-omics to maximize the scientific value of pediatric sepsis biorepository and advance patient endotyping

Grant Number:

4R33GM151703-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/5/2023

End Date:

6/30/2027

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

Leveraging multi-omics to maximize the scientific value of pediatric sepsis biorepository and advance patient endotyping. PROJECT SUMMARY: Sepsis is major pediatric health problem and kills more children than cancer in the U.S each year. Primarily driven by a dysfunctional host response to an infec...

Research Terms

<0-11 years old><Address><Affect><Antibiotic Agents><Antibiotic Drugs><Antibiotics><BeadChip><Bioinformatics><Biological><Biology><Blood Sample><Blood specimen><Cancers><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Data><Clinical Trials><Collection><Communities><CpG Islands><CpG-Rich Islands><Critical Illness><Critically Ill><Critically ill children><DNA><DNA Methylation><DNA methylation profiling><Data><Data Bases><Data Set><Databases><Deoxyribonucleic Acid><Derivation><Derivation procedure><Development><Dimensions><Disease><Disorder><Drugs><Dysfunction><Electronic Health Record><Ensure><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Equity><Evolution><Factor Analyses><Factor Analysis><Feasibility Studies><Foundations><Functional disorder><Funding><Future><Gene Action Regulation><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic Transcription><Health><Human><Immune response><Infection><Investigators><Knowledge><Laboratories><Life><Link><Malignant Neoplasms><Malignant Tumor><Medication><Messenger RNA><Methodology><Methods><Methyl-Seq><MethylSeq><Methylation><Methylation sequencing><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Morbidity><Morbidity - disease rate><NIGMS><National Institute of General Medical Sciences><Nature><Non-Polyadenylated RNA><Organ><Outcome><Pathway interactions><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Pharmaceutical Preparations><Phase><Phased Innovation Awards><Physiopathology><Precision therapeutics><Process><Quality Control><R21/R33 Mechanism><R21/R33 Program><RNA><RNA Expression><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Reporting><Research><Research Personnel><Research Specimen><Researchers><Ribonucleic Acid><Role><Sampling><Scientific Advances and Accomplishments><Sepsis><Septic Shock><Series><Specimen><Subgroup><Testing><Time><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><Validation><Whole Blood><analyze gene expression><antisepsis treatment><bead chip><biobank><biologic><biological heterogeneity><biorepository><care for patients><care of patients><caring for patients><child patients><children with sepsis><clinical relevance><clinical significance><clinically relevant><clinically significant><cohort><critically ill child><data base><data integration><depository><developmental><disease subgroups><disease subtype><disorder subtype><drug/agent><efficacious therapy><efficacious treatment><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><epigenetically><epigenome><epigenomics><gene classifier><gene expression analysis><gene expression assay><gene regulatory network><genetic classifier><genomic classifier><global gene expression><global transcription profile><host response><immune system response><immunoresponse><improved><individuals with sepsis><kids><mRNA><malignancy><methylome><methylomics><mortality><multiomics><multiple omics><neoplasm/cancer><novel><panomics><pathophysiology><pathway><patient oriented outcomes><patient response><patient specific response><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><patients with sepsis><pediatric><pediatric patients><pediatric sepsis><pediatric septic><people with sepsis><performance tests><power analysis><precision medicine><precision therapies><precision treatment><precision-based medicine><prevent><preventing><public health emergency><repository><response to therapy><response to treatment><responsive patient><scale up><scientific accomplishments><scientific advances><sepsis care><sepsis groups><sepsis in children><sepsis interventions><sepsis management><sepsis patients><sepsis population><sepsis subjects><sepsis therapeutics><sepsis therapy><sepsis treatment><septic children><septic group><septic individuals><septic patients><septic people><septic population><septic subject><septic therapy><septic treatment><social role><subjects with sepsis><systemic inflammation><systemic inflammatory response><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic response><therapy response><transcriptional profiling><transcriptome><transcriptome sequencing><transcriptomic sequencing><transcriptomics><treat sepsis><treatment response><treatment responsiveness><validations><youngster>
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JEFFREY A KAYE

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Exploratory lead · 28/100
Above-average budget
Active award
$647,061
FY 2025

Project Title

The Pacific Aging and Cancer Studies (PACS): An Infrastructure Advancing the Use of Digital Biomarkers and Related Technologies for Research on Functional Aging and Survivorship in Cancer

Grant Number:

4R33CA280994-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/4/2023

End Date:

7/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT By for speed survivors. 2040, the proportion of cancer survivors who are over 65 years of age will rise to 73% and most will survive 5 years or longer 1 . Cancer treatment an accelerate aging and cause new impairments that ogether can the trajectory of functional losses a...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Acceleration><Accelerometer><Address><Age><Age Years><Aged 65 and Over><Aging><Biology><Biometrics><Biometry><Biostatistics><Cancer Science><Cancer Survivor><Cancer Survivorship><Cancer Treatment><Cancers><Caring><Cell Communication and Signaling><Cell Signaling><Characteristics><Clinical><Clinical assessments><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Complex><Data><Data Analytics><Data Collection><Dedications><Dependence><Diagnosis><Digital biomarker><Dimensions><Disease><Disorder><Disturbance in cognition><Dysfunction><Elderly><Electronics><Ensure><Fall prevention><Family><Functional disorder><Funding><Geroscience><Health><Health Care Systems><Hematology><Home><Iatrogenic Cancer><Impaired cognition><Impairment><Infrastructure><Intracellular Communication and Signaling><Investigators><Knowledge><Learning><Life><Longitudinal Studies><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Married Persons><Measures><Medical><Methodology><Methods><Monitor><Moods><Morbidity><Morbidity - disease rate><NIH><National Institutes of Health><Oncology><Oncology Cancer><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patients><Perception><Personal Satisfaction><Persons><Phase><Phased Innovation Awards><Physiopathology><Productivity><Protocol><Protocols documentation><Public Health><QOL><Quality of life><R21/R33 Mechanism><R21/R33 Program><Reporting><Research><Research Infrastructure><Research Personnel><Researchers><Risk><Risk Factors><Signal Transduction><Signal Transduction Systems><Signaling><Sleep disturbances><Socialization><Speed><Spouses><Survey Instrument><Surveys><Survivors><Symptoms><Technology><Therapy Related Malignant Neoplasm><Therapy Related Malignant Tumor><Therapy-Associated Cancers><Therapy-Related Cancer><Time><Treatment-Associated Cancer><Treatment-Related Cancer><United States National Institutes of Health><Work><aberrant aging><aberrant sleep><abnormal aging><above age 65><accelerated aging><accelerated biological age><accelerated biological aging><accelerometry><activity monitor><activity tracker><advanced age><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age acceleration><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><ages><aging process><anti-cancer research><anti-cancer therapy><behavioral health><biological signal transduction><cancer care><cancer research><cancer therapy><cancer-directed therapy><care partner><caregiving partner><cognitive dysfunction><cognitive loss><community advisory board><community advisory committee><community advisory panel><continuous monitoring><daily functioning><data integration><decline in function><decline in functional status><design><designing><digital assessment><digital marker><digital technology><digital tool><digital toolkit><disability><disrupted sleep><disturbed sleep><dysfunctional age related change><dysfunctional aging><early onset><elderly patient><electronic><electronic device><end of life><end-of-life><falls><frailty><functional decline><functional disability><functional loss><functional status decline><geriatric><geroscientific><high dimensional data><homes><human old age (65+)><impaired aging><impaired sleep><infrastructure development><interdisciplinary collaboration><irregular sleep><long-term study><longitudinal outcome studies><maladaptive aging><malignancy><multidimensional data><multidimensional datasets><multimorbidity><multiple chronic conditions><natural aging><neoplasm/cancer><normal aging><normative aging><novel><older adult><older adulthood><older patient><over 65 years><participatory sensing><pathological age related changes><pathological aging><pathophysiology><preventing falls><protective factors><remote assessment><remote evaluation><remote sensing><response><scale up><senior citizen><sensor><side effect><sleep disruption><sleep dysregulation><sleep/wake disruption><sleep/wake disturbance><survivorship><technology platform><technology system><transdisciplinary collaboration><trial readiness><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><well-being><wellbeing><≥65 years>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

KERRI M WINTERS-STONE

OREGON HEALTH & SCIENCE UNIVERSITY, PORTLAND, OR

Exploratory lead · 28/100
Above-average budget
Active award
$647,061
FY 2025

Project Title

The Pacific Aging and Cancer Studies (PACS): An Infrastructure Advancing the Use of Digital Biomarkers and Related Technologies for Research on Functional Aging and Survivorship in Cancer

Grant Number:

4R33CA280994-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/4/2023

End Date:

7/31/2028

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY/ABSTRACT By for speed survivors. 2040, the proportion of cancer survivors who are over 65 years of age will rise to 73% and most will survive 5 years or longer 1 . Cancer treatment an accelerate aging and cause new impairments that ogether can the trajectory of functional losses a...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Acceleration><Accelerometer><Address><Age><Age Years><Aged 65 and Over><Aging><Biology><Biometrics><Biometry><Biostatistics><Cancer Science><Cancer Survivor><Cancer Survivorship><Cancer Treatment><Cancers><Caring><Cell Communication and Signaling><Cell Signaling><Characteristics><Clinical><Clinical assessments><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Complex><Data><Data Analytics><Data Collection><Dedications><Dependence><Diagnosis><Digital biomarker><Dimensions><Disease><Disorder><Disturbance in cognition><Dysfunction><Elderly><Electronics><Ensure><Fall prevention><Family><Functional disorder><Funding><Geroscience><Health><Health Care Systems><Hematology><Home><Iatrogenic Cancer><Impaired cognition><Impairment><Infrastructure><Intracellular Communication and Signaling><Investigators><Knowledge><Learning><Life><Longitudinal Studies><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Married Persons><Measures><Medical><Methodology><Methods><Monitor><Moods><Morbidity><Morbidity - disease rate><NIH><National Institutes of Health><Oncology><Oncology Cancer><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patients><Perception><Personal Satisfaction><Persons><Phase><Phased Innovation Awards><Physiopathology><Productivity><Protocol><Protocols documentation><Public Health><QOL><Quality of life><R21/R33 Mechanism><R21/R33 Program><Reporting><Research><Research Infrastructure><Research Personnel><Researchers><Risk><Risk Factors><Signal Transduction><Signal Transduction Systems><Signaling><Sleep disturbances><Socialization><Speed><Spouses><Survey Instrument><Surveys><Survivors><Symptoms><Technology><Therapy Related Malignant Neoplasm><Therapy Related Malignant Tumor><Therapy-Associated Cancers><Therapy-Related Cancer><Time><Treatment-Associated Cancer><Treatment-Related Cancer><United States National Institutes of Health><Work><aberrant aging><aberrant sleep><abnormal aging><above age 65><accelerated aging><accelerated biological age><accelerated biological aging><accelerometry><activity monitor><activity tracker><advanced age><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age acceleration><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><ages><aging process><anti-cancer research><anti-cancer therapy><behavioral health><biological signal transduction><cancer care><cancer research><cancer therapy><cancer-directed therapy><care partner><caregiving partner><cognitive dysfunction><cognitive loss><community advisory board><community advisory committee><community advisory panel><continuous monitoring><daily functioning><data integration><decline in function><decline in functional status><design><designing><digital assessment><digital marker><digital technology><digital tool><digital toolkit><disability><disrupted sleep><disturbed sleep><dysfunctional age related change><dysfunctional aging><early onset><elderly patient><electronic><electronic device><end of life><end-of-life><falls><frailty><functional decline><functional disability><functional loss><functional status decline><geriatric><geroscientific><high dimensional data><homes><human old age (65+)><impaired aging><impaired sleep><infrastructure development><interdisciplinary collaboration><irregular sleep><long-term study><longitudinal outcome studies><maladaptive aging><malignancy><multidimensional data><multidimensional datasets><multimorbidity><multiple chronic conditions><natural aging><neoplasm/cancer><normal aging><normative aging><novel><older adult><older adulthood><older patient><over 65 years><participatory sensing><pathological age related changes><pathological aging><pathophysiology><preventing falls><protective factors><remote assessment><remote evaluation><remote sensing><response><scale up><senior citizen><sensor><side effect><sleep disruption><sleep dysregulation><sleep/wake disruption><sleep/wake disturbance><survivorship><technology platform><technology system><transdisciplinary collaboration><trial readiness><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><well-being><wellbeing><≥65 years>
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Jennifer Melissa Kaplan

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

Exploratory lead · 28/100
Above-average budget
Active award
$516,797
FY 2025

Project Title

Biobank of small extracellular vesicles for pediatric sepsis

Grant Number:

4R33GM151734-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/17/2023

End Date:

6/30/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Sepsis is a dysregulated host response to an infection and can lead to multiple organ dysfunction syndrome (MODS). There are no effective treatments for sepsis-induced MODS most likely because of the heterogeneity of the syndrome. Delineating MODS endotypes and molecular signatures o...

Research Terms

<0-11 years old><Affect><Biochemical><Biogenesis><Biological><Biological Markers><Blood Cells><Blood Plasma><Blood Sample><Blood Serum><Blood specimen><Body Fluids><Body Tissues><Categories><Cell Body><Cell Communication><Cell Interaction><Cell-to-Cell Interaction><Cells><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Classification><Clinical><Clinical Trials><Collection><Complex><Critical Care><Critical Illness><Critically Ill><Data><Data Set><Development><Diagnostics Research><Disease><Disorder><Distant><Dysfunction><Endosomes><Endothelial Cells><Freezing><Functional disorder><Funding><Future><Genomics><Goals><Harvest><Health><Heart><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Heterogeneity><Human><Immune><Immune response><Immunes><In Vitro><Infection><Inflammatory><Inflammatory Response><Investigation><Investigators><Kidney><Kidney Urinary System><Lipids><Liquid substance><Liver><Liver Cells><Lung><Lung Respiratory System><MOF syndrome><Membrane><Methodology><MicroRNAs><Mind><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Morbidity><Morbidity - disease rate><Multiple Organ Dysfunction Syndrome><Multiple Organ Failure><NIGMS><National Institute of General Medical Sciences><Non-Polyadenylated RNA><Nucleic Acids><Organ><Organ failure><Origin of Life><Outcome><Patients><Pediatric cohort><Peripheral Blood Cell><Phase><Phased Innovation Awards><Phenotype><Phosphatides><Phospholipids><Physiopathology><Plasma><Plasma Serum><Population Heterogeneity><Precision therapeutics><Procedures><Process><Proteins><Proteomics><Protocol><Protocols documentation><Quality Control><R21/R33 Mechanism><R21/R33 Program><RNA><RNA Gene Products><RNA Seq><RNA analysis><RNA sequencing><RNAseq><Receptosomes><Reproducibility><Research><Research Personnel><Research Specimen><Researchers><Reticuloendothelial System, Serum, Plasma><Ribonucleic Acid><Sampling><Sepsis><Septic Shock><Serum><Source><Specimen><Standardization><Syndrome><Systematics><Therapeutic Research><Time><Tissues><antisepsis treatment><beta lactam antibiotic><beta-Lactams><bio-markers><biobank><biologic><biologic marker><biomarker><biomarker identification><biophysical characteristics><biophysical characterization><biophysical measurement><biophysical parameters><biophysical properties><biorepository><cell type><child patients><children with sepsis><cohort><depository><developmental><diverse populations><effective therapy><effective treatment><exosome><extracellular vesicles><fluid><hepatic body system><hepatic organ system><heterogeneous population><high throughput analysis><host response><identification of biomarkers><identification of new biomarkers><immune system response><immunoresponse><improved><individual heterogeneity><individual variability><individual variation><individuals with sepsis><injury to organs><kids><lipidomics><liquid><liquid biopsy><marker identification><membrane structure><metabolism measurement><metabolomics><metabonomics><miRNA><molecular profile><molecular signature><mortality><multiorgan failure><multiple organ system failure><nanostring><novel><organ injury><particle><pathophysiology><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><patients with sepsis><pediatric><pediatric patients><pediatric sepsis><pediatric septic><people with sepsis><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pharmacometrics><population diversity><potential biological marker><potential biomarker><precision therapies><precision treatment><prospective><renal><repository><sample collection><sepsis care><sepsis groups><sepsis in children><sepsis interventions><sepsis management><sepsis patients><sepsis population><sepsis subjects><sepsis therapeutics><sepsis therapy><sepsis treatment><septic><septic children><septic group><septic individuals><septic patients><septic people><septic population><septic subject><septic therapy><septic treatment><specimen collection><subjects with sepsis><tool><trait><transcriptome sequencing><transcriptomic sequencing><transcriptomics><treat sepsis><treatment strategy><youngster><β lactam antibiotic><β-Lactams>
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BASILIA ZINGARELLI

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

Exploratory lead · 28/100
Above-average budget
Active award
$516,797
FY 2025

Project Title

Biobank of small extracellular vesicles for pediatric sepsis

Grant Number:

4R33GM151734-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/17/2023

End Date:

6/30/2026

Why this may be worth a closer look

  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Sepsis is a dysregulated host response to an infection and can lead to multiple organ dysfunction syndrome (MODS). There are no effective treatments for sepsis-induced MODS most likely because of the heterogeneity of the syndrome. Delineating MODS endotypes and molecular signatures o...

Research Terms

<0-11 years old><Affect><Biochemical><Biogenesis><Biological><Biological Markers><Blood Cells><Blood Plasma><Blood Sample><Blood Serum><Blood specimen><Body Fluids><Body Tissues><Categories><Cell Body><Cell Communication><Cell Interaction><Cell-to-Cell Interaction><Cells><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Classification><Clinical><Clinical Trials><Collection><Complex><Critical Care><Critical Illness><Critically Ill><Data><Data Set><Development><Diagnostics Research><Disease><Disorder><Distant><Dysfunction><Endosomes><Endothelial Cells><Freezing><Functional disorder><Funding><Future><Genomics><Goals><Harvest><Health><Heart><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Heterogeneity><Human><Immune><Immune response><Immunes><In Vitro><Infection><Inflammatory><Inflammatory Response><Investigation><Investigators><Kidney><Kidney Urinary System><Lipids><Liquid substance><Liver><Liver Cells><Lung><Lung Respiratory System><MOF syndrome><Membrane><Methodology><MicroRNAs><Mind><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Morbidity><Morbidity - disease rate><Multiple Organ Dysfunction Syndrome><Multiple Organ Failure><NIGMS><National Institute of General Medical Sciences><Non-Polyadenylated RNA><Nucleic Acids><Organ><Organ failure><Origin of Life><Outcome><Patients><Pediatric cohort><Peripheral Blood Cell><Phase><Phased Innovation Awards><Phenotype><Phosphatides><Phospholipids><Physiopathology><Plasma><Plasma Serum><Population Heterogeneity><Precision therapeutics><Procedures><Process><Proteins><Proteomics><Protocol><Protocols documentation><Quality Control><R21/R33 Mechanism><R21/R33 Program><RNA><RNA Gene Products><RNA Seq><RNA analysis><RNA sequencing><RNAseq><Receptosomes><Reproducibility><Research><Research Personnel><Research Specimen><Researchers><Reticuloendothelial System, Serum, Plasma><Ribonucleic Acid><Sampling><Sepsis><Septic Shock><Serum><Source><Specimen><Standardization><Syndrome><Systematics><Therapeutic Research><Time><Tissues><antisepsis treatment><beta lactam antibiotic><beta-Lactams><bio-markers><biobank><biologic><biologic marker><biomarker><biomarker identification><biophysical characteristics><biophysical characterization><biophysical measurement><biophysical parameters><biophysical properties><biorepository><cell type><child patients><children with sepsis><cohort><depository><developmental><diverse populations><effective therapy><effective treatment><exosome><extracellular vesicles><fluid><hepatic body system><hepatic organ system><heterogeneous population><high throughput analysis><host response><identification of biomarkers><identification of new biomarkers><immune system response><immunoresponse><improved><individual heterogeneity><individual variability><individual variation><individuals with sepsis><injury to organs><kids><lipidomics><liquid><liquid biopsy><marker identification><membrane structure><metabolism measurement><metabolomics><metabonomics><miRNA><molecular profile><molecular signature><mortality><multiorgan failure><multiple organ system failure><nanostring><novel><organ injury><particle><pathophysiology><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><patients with sepsis><pediatric><pediatric patients><pediatric sepsis><pediatric septic><people with sepsis><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pharmacometrics><population diversity><potential biological marker><potential biomarker><precision therapies><precision treatment><prospective><renal><repository><sample collection><sepsis care><sepsis groups><sepsis in children><sepsis interventions><sepsis management><sepsis patients><sepsis population><sepsis subjects><sepsis therapeutics><sepsis therapy><sepsis treatment><septic><septic children><septic group><septic individuals><septic patients><septic people><septic population><septic subject><septic therapy><septic treatment><specimen collection><subjects with sepsis><tool><trait><transcriptome sequencing><transcriptomic sequencing><transcriptomics><treat sepsis><treatment strategy><youngster><β lactam antibiotic><β-Lactams>
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Brian Jason Wainger

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 26/100
Solid budget
Active award
$484,178
FY 2026

Project Title

Toward Precision Gene Therapy for Treatment of Severe Pain in Older Individuals

Grant Number:

5R33AG075419-05

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2022

End Date:

2/28/2027

Project Abstract

Project Summary: The primary goal of this R21/R33 Translational Aging Research Identification award is develop, optimize, and validate a novel gene therapy-based treatment approach for refractory pain in older individuals. Pain is a major socioeconomic problem, affecting more than 25% of adults in t...

Research Terms

<21+ years old><AAV delivered><AAV delivery><AAV-based delivery><AAV-based viral delivery><AAV-mediated delivery><Adeno-associated-virus-based delivery><Adult><Adult Human><Adverse effects><Affect><Aging><Animal Model><Animal Models and Related Studies><Arthritis><Award><Behavioral><Bioinformatics><Biology><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell model><Cells><Cellular model><Clinical Trials><Congenital Analgesia><Congenital Pain Indifference><Congenital Pain Insensitivity><Contralateral><DNA Therapy><Data><Development><Dorsal Root Ganglia><Dose><Drug usage><Elderly><Electrophysiology><Electrophysiology (science)><Gene Therapy Vectors><Gene Transcription><Gene Transduction Agent><Gene Transduction Vectors><Gene Transfer Clinical><Genes><Genetic Intervention><Genetic Models><Genetic Transcription><Goals><Hereditary><Human><Human Genetics><Impairment><Individual><Inflammatory><Inherited><Injections><Intra-Articular Injections><Intraarticular Injections><Intracellular Communication and Signaling><Intractable Pain><Intramuscular><Ipsilateral><K channel><Knock-out><Knockout><Label><Measures><Medical><Medulla Spinalis><Mice><Mice Mammals><Modern Man><Molecular><Motor Cell><Motor Neurons><Murine><Mus><Neural Stem Cell><Neuropathy><Neurophysiology / Electrophysiology><Nociceptors><Older Population><Pain><Pain Control><Pain Therapy><Pain management><Painful><Pathologic><Phase><Phenotype><Physiologic><Physiological><Polypharmacy><Post-operative Pain><Postoperative Pain><Potassium Channel><Potassium Ion Channels><Prevalence><Promoter Regions><Promotor Regions><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><RNA Expression><Refractory Pain><Research><Risk><Route><Safety><Serotyping><Signal Transduction><Signal Transduction Systems><Signaling><Sodium Channel><Sodium Ion Channels><Specificity><Spinal Cord><Spinal Ganglia><Testing><Toxic effect><Toxicities><Transcript><Transcription><Translations><Validation><Voltage-Gated K+ Channels><Voltage-Gated Potassium Channel><adeno-associated viral vector delivery><adeno-associated virus delivery><adeno-associated virus mediated delivery><adenovirus mediated delivery><adulthood><advanced age><aged animal><aged animals><aged mice><aged mouse><aggressive therapy><aggressive treatment><animal old age><arthritic><biological signal transduction><cell type><chronic pain><co-morbid><co-morbidity><comorbidity><congenital hyposensitivity to pain><congenital insensitivity to pain><cost><delivered with AAV><delivery with AAV><dermatome><design><designing><developmental><dorsal root ganglion><drug use><effective therapy><effective treatment><elderly animal><elderly mice><elderly patient><electrophysiological><experience><familial hyposensitivity to pain><familial insensitivity to pain><gain of function mutation><gene repair therapy><gene therapy><gene-based therapy><genetic promoter element><genetic promoter sequence><genetic therapy><genomic therapy><geriatric><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSCs><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><intractable pain syndrome><knock-down><knockdown><model of animal><motoneuron><mouse model><murine model><nerve stem cell><neural cell body><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal cell body><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuropathic><neuroprogenitor><new approaches><nociceptive neurons><novel><novel approaches><novel strategies><novel strategy><old animals><old mice><older groups><older individuals><older patient><older person><opiate crisis><opioid crisis><opioid epidemic><overexpress><overexpression><pain after surgery><pain intervention><pain model><pain signal><pain treatment><pain-sensing neurons><pain-sensing sensory neurons><pain-sensing somatosensory neurons><patch clamp><patch sequencing><patch-seq><patchseq><post-surgical pain><postsurgical pain><pre-clinical development><preclinical development><prevent><preventing><progenitor and neural stem cells><progenitor cell model><progenitor model><promoter><promoter sequence><promotor><qRTPCR><senior citizen><side effect><socio-economic><socio-economically><socioeconomically><socioeconomics><soma><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapy optimization><translation><treatment optimization><treatment strategy><validations><voltage>
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Caitlin Shannon Latimer

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 26/100
Solid budget
Active award
$481,277
FY 2026

Project Title

Investigating the relationship between the AD risk gene SORL1 and TDP-43 pathology in Alzheimer's Disease

Grant Number:

1R21AG094020-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2027

Project Abstract

Summary TDP-43 pathology occurs in the majority of individuals with high Alzheimer's disease neuropathologic change (ADNC). This accumulation of cytoplasmic hyperphosphorylated aggregates of TDP-43 (pTDP-43) in neurons has been termed limbic predominant age-related TDP-43 encephalopathy neuropatholo...

Research Terms

<AD dementia><AD pathology><AD risk><AD risk factor><APP processing><Affect><Age of Onset><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's pathology><Alzheimer's precursor protein><Alzheimers Dementia><Amyloid A4 Protein Precursor><Amyloid Protein Precursor><Amyloid beta-Protein Precursor><Amyloid β-Protein Precursor><Amyotrophic lateral sclerosis and frontotemporal degeneration><Amyotrophic lateral sclerosis and frontotemporal dementia><Assay><Astrocytes><Astrocytus><Astroglia><Autopsy><Bioassay><Biological Assay><Body Tissues><Brain><Brain Nervous System><Brain region><CURL><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell model><Cells><Cellular Stress><Cellular Stress Response><Cellular model><Characteristics><Compartment of the Uncoupling Receptors and Ligands><Cytoplasm><Development><Dysfunction><ER stress><Early Endosome><Encephalon><Endosomes><Exons><FTD/ALS><FTLD><FTLD/ALS><Family><Frontal Temporal Lobar Degeneration><Frontotemporal Lobar Degeneration/Amyotrophic lateral sclerosis><Frontotemporal Lobar Degenerations><Frontotemporal variety lobar degeneration><Functional disorder><Genes><Genetic><Glia><Glial Cells><Goals><Human><In Vitro><Individual><Intracellular Communication and Signaling><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Lead><Link><Lysosomes><Modeling><Modern Man><Molecular><Morphology><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neuron Degeneration><Neurons><Non-neuronal cell><Nonneuronal cell><Organelles><Pathogenicity><Pathologic><Pathology><Pathway interactions><Patients><Pb element><Phenotype><Phosphorylation><Physiopathology><Play><Predisposition><Primary Senile Degenerative Dementia><Process><Protein Cleavage><Protein Phosphorylation><Proteins><Proteolysis><RNA Splicing><Receptosomes><Recycling><Regulation><Research><Research Resources><Resources><Risk-associated variant><Role><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Splicing><Staining method><Stains><Susceptibility><System><TAR DNA binding protein 43 kDa pathology><TAR DNA binding protein 43 pathology><TAR DNA binding protein of 43 proteinopathy><TAR DNA-binding protein 43><TDP-43><TDP-43 aggregate><TDP-43 aggregation><TDP43><TDP43 aggregate><TDP43 aggregation><TDP43 associated neurodegeneration><TDP43 associated neurodegenerative disease><TDP43 associated pathologies><TDP43 induced neurodegeneration><TDP43 neurodegeneration><TDP43 neurodegenerative disease><TDP43 neuropathology><TDP43 pathogenesis><TDP43 pathology><TDP43 proteinopathy><TDP43 related neurodegeneration><TDP43 related pathology><Testing><Therapeutic Intervention><Tissue Donors><Tissues><Trans active response DNA binding protein 43 pathology><Trans active response DNA binding protein of 43 kDa proteinopathy><Universities><Variant><Variation><Washington><alzheimer risk><amyloid precursor protein><amyloid precursor protein processing><amyotrophic lateral sclerosis with frontotemporal dementia><amyotrophic lateral sclerosis/FTLD><amyotrophic lateral sclerosis/frontotemporal dementia><amyotrophic lateral sclerosis/ftd><astrocytic glia><astrogliosis><biological signal transduction><brain tissue><cell stress><cell type><cellular pathology><co-morbid><co-morbidity><cohort><comorbidity><developmental><disease causing variant><disease-causing allele><disease-causing mutation><endoplasmic reticulum stress><experiment><experimental research><experimental study><experiments><frontotemporal dementia-amyotrophic lateral sclerosis><frontotemporal lobar dementia amyotrophic lateral sclerosis><heavy metal Pb><heavy metal lead><hiPSC><high resolution imaging><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><induced human pluripotent stem cells><intervention therapy><knock-down><knockdown><late onset alzheimer><limbic-predominant age-related TDP-43 encephalopathy><limbic-predominant age-related TDP43 encephalopathy><necropsy><nerve cement><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal><neuronal degeneration><neuropathologic><neuropathological><neuropathology><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><pathogenic allele><pathogenic variant><pathophysiology><pathway><postmortem><primary degenerative dementia><progenitor cell model><progenitor model><protein TDP-43><protein TDP43><risk allele><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk gene><risk genotype><risk loci><risk locus><risk of developing Alzheimer's><risk variant><segregation><senile dementia of the Alzheimer type><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><trafficking><trans active response DNA binding protein 43 kDa pathology><trans active response DNA binding protein 43 proteinopathy><younger age>
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Jessica Elaine Young

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 26/100
Solid budget
Active award
$481,277
FY 2026

Project Title

Investigating the relationship between the AD risk gene SORL1 and TDP-43 pathology in Alzheimer's Disease

Grant Number:

1R21AG094020-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2027

Project Abstract

Summary TDP-43 pathology occurs in the majority of individuals with high Alzheimer's disease neuropathologic change (ADNC). This accumulation of cytoplasmic hyperphosphorylated aggregates of TDP-43 (pTDP-43) in neurons has been termed limbic predominant age-related TDP-43 encephalopathy neuropatholo...

Research Terms

<AD dementia><AD pathology><AD risk><AD risk factor><APP processing><Affect><Age of Onset><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease pathology><Alzheimer's disease risk><Alzheimer's pathology><Alzheimer's precursor protein><Alzheimers Dementia><Amyloid A4 Protein Precursor><Amyloid Protein Precursor><Amyloid beta-Protein Precursor><Amyloid β-Protein Precursor><Amyotrophic lateral sclerosis and frontotemporal degeneration><Amyotrophic lateral sclerosis and frontotemporal dementia><Assay><Astrocytes><Astrocytus><Astroglia><Autopsy><Bioassay><Biological Assay><Body Tissues><Brain><Brain Nervous System><Brain region><CURL><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell model><Cells><Cellular Stress><Cellular Stress Response><Cellular model><Characteristics><Compartment of the Uncoupling Receptors and Ligands><Cytoplasm><Development><Dysfunction><ER stress><Early Endosome><Encephalon><Endosomes><Exons><FTD/ALS><FTLD><FTLD/ALS><Family><Frontal Temporal Lobar Degeneration><Frontotemporal Lobar Degeneration/Amyotrophic lateral sclerosis><Frontotemporal Lobar Degenerations><Frontotemporal variety lobar degeneration><Functional disorder><Genes><Genetic><Glia><Glial Cells><Goals><Human><In Vitro><Individual><Intracellular Communication and Signaling><Kolliker's reticulum><Late Onset Alzheimer Disease><Late onset AD><Lead><Link><Lysosomes><Modeling><Modern Man><Molecular><Morphology><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neuron Degeneration><Neurons><Non-neuronal cell><Nonneuronal cell><Organelles><Pathogenicity><Pathologic><Pathology><Pathway interactions><Patients><Pb element><Phenotype><Phosphorylation><Physiopathology><Play><Predisposition><Primary Senile Degenerative Dementia><Process><Protein Cleavage><Protein Phosphorylation><Proteins><Proteolysis><RNA Splicing><Receptosomes><Recycling><Regulation><Research><Research Resources><Resources><Risk-associated variant><Role><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Splicing><Staining method><Stains><Susceptibility><System><TAR DNA binding protein 43 kDa pathology><TAR DNA binding protein 43 pathology><TAR DNA binding protein of 43 proteinopathy><TAR DNA-binding protein 43><TDP-43><TDP-43 aggregate><TDP-43 aggregation><TDP43><TDP43 aggregate><TDP43 aggregation><TDP43 associated neurodegeneration><TDP43 associated neurodegenerative disease><TDP43 associated pathologies><TDP43 induced neurodegeneration><TDP43 neurodegeneration><TDP43 neurodegenerative disease><TDP43 neuropathology><TDP43 pathogenesis><TDP43 pathology><TDP43 proteinopathy><TDP43 related neurodegeneration><TDP43 related pathology><Testing><Therapeutic Intervention><Tissue Donors><Tissues><Trans active response DNA binding protein 43 pathology><Trans active response DNA binding protein of 43 kDa proteinopathy><Universities><Variant><Variation><Washington><alzheimer risk><amyloid precursor protein><amyloid precursor protein processing><amyotrophic lateral sclerosis with frontotemporal dementia><amyotrophic lateral sclerosis/FTLD><amyotrophic lateral sclerosis/frontotemporal dementia><amyotrophic lateral sclerosis/ftd><astrocytic glia><astrogliosis><biological signal transduction><brain tissue><cell stress><cell type><cellular pathology><co-morbid><co-morbidity><cohort><comorbidity><developmental><disease causing variant><disease-causing allele><disease-causing mutation><endoplasmic reticulum stress><experiment><experimental research><experimental study><experiments><frontotemporal dementia-amyotrophic lateral sclerosis><frontotemporal lobar dementia amyotrophic lateral sclerosis><heavy metal Pb><heavy metal lead><hiPSC><high resolution imaging><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><induced human pluripotent stem cells><intervention therapy><knock-down><knockdown><late onset alzheimer><limbic-predominant age-related TDP-43 encephalopathy><limbic-predominant age-related TDP43 encephalopathy><necropsy><nerve cement><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal><neuronal degeneration><neuropathologic><neuropathological><neuropathology><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><overexpress><overexpression><pathogenic allele><pathogenic variant><pathophysiology><pathway><postmortem><primary degenerative dementia><progenitor cell model><progenitor model><protein TDP-43><protein TDP43><risk allele><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk gene><risk genotype><risk loci><risk locus><risk of developing Alzheimer's><risk variant><segregation><senile dementia of the Alzheimer type><social role><stem and progenitor cell model><stem cell based model><stem cell derived model><stem cell model><trafficking><trans active response DNA binding protein 43 kDa pathology><trans active response DNA binding protein 43 proteinopathy><younger age>
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BENJAMIN JOACHIM SCHMIEDEL

LA JOLLA INSTITUTE FOR IMMUNOLOGY, LA JOLLA, CA

Exploratory lead · 26/100
Solid budget
Active award
$476,436
FY 2026

Project Title

Defining function and regulation of the novel SLE-susceptibility gene ILRUN in T cells

Grant Number:

1R21AI197006-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT Systemic lupus erythematous (SLE) causes substantial mortality and morbidity. Current treatments are not highly effective in modifying disease progression, especially in severely affected patients with renal involvement. Hence, there is a large unmet need to develop novel th...

Research Terms

<ASCVD><Affect><Apoptosis><Apoptosis Pathway><Assay><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Autoimmune Diseases><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Binding><Bioassay><Biological Assay><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CRISPR interference><CRISPR-dCas9-mediated repression><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Cell Body><Cells><ChIP assay><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats interference><DNA Sequence><Data Bases><Data Set><Databases><Development><Disease><Disease Progression><Disorder><Drug Targeting><Enhancers><Exploratory/Developmental Grant><Expression Signature><Functional RNA><Future><GWA study><GWAS><Gene Expression><Gene Expression Profile><Gene variant><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Markers><Hereditary><Human><IFN-regulatory factor 3><IRF-3 protein><IRF3><IRF3 gene><Immune><Immunes><Immunology><In Vitro><Individual><Infection><Inflammation><Inflammatory><Inherited><Interferon Regulatory Factor 3><Interferon Type I><Kidney><Kidney Urinary System><Link><Lipids><Luciferase Immunologic><Luciferases><Lupus Erythematosus Disseminatus><Malignant Cell><Mediating><Mice><Mice Mammals><Modern Man><Molecular><Molecular Interaction><Morbidity><Murine><Mus><Noncoding RNA><Nontranslated RNA><Outcome><PPAR alpha><PPAR-α><PPARalpha><PPARα><Pathogenesis><Pathogenicity><Pathway interactions><Patients><Peroxisome Proliferator-Activated Receptor alpha><Peroxisome Proliferator-Activated Receptor α><Phase III study><Phenotype><Play><Population><Predisposition gene><Production><Programmed Cell Death><Proliferating><Proteins><Publishing><QTL><Quantitative Trait Loci><R21 Mechanism><R21 Program><RNA Seq><RNA sequencing><RNAseq><Regulation><Reporter><Rest><Risk><Risk-associated variant><Role><SLE><Science><Severity of illness><Susceptibility Gene><Systemic Lupus Erythematosus><Systemic Lupus Erythematous><Systemic Lupus Erythmatosus><T-Cell Activation><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T4 Cells><T4 Lymphocytes><Testing><Transcript><Transcription Factor Proto-Oncogene><Transcription factor genes><Translations><Untranslated RNA><Variant><Variation><Work><activate T cells><allelic variant><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><autoimmune condition><autoimmune disorder><autoimmunity disease><cancer cell><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cell type><chromatin immunoprecipitation><cytokine><data base><developmental><disease risk><disease severity><disorder risk><disseminated lupus erythematosus><driving><epigenomics><exploratory developmental study><gene biomarker><gene expression biomarker><gene expression pattern><gene expression signature><gene locus><gene marker><gene signature biomarker><genetic association><genetic biomarker><genetic locus><genetic variant><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic location><genomic locus><genomic variant><global gene expression><global transcription profile><human tissue><improved><in vivo><insight><knock-down><knockdown><mortality><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><noncoding><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><phase 3 study><predisposing gene><promoter><promotor><renal><repressing CRISPR-dCas9 system><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><social role><susceptibility allele><susceptibility locus><susceptibility variant><systemic lupus erythematosis><therapeutic target><thymus derived lymphocyte><transcription factor><transcriptional profile><transcriptional signature><transcriptome><transcriptome sequencing><transcriptomic sequencing><translation><tumor growth><whole genome association analysis><whole genome association study>
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Juan Lafaille

NEW YORK UNIVERSITY SCHOOL OF MEDICINE, NEW YORK, NY

Exploratory lead · 26/100
Solid budget
Active award
$466,125
FY 2026

Project Title

Perivascular macrophages control the severity of experimental autoimmune encephalomyelitis

Grant Number:

1R21AI191646-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/3/2026

End Date:

1/31/2028

Project Abstract

Summary Central Nervous system (CNS) perivascular macrophages are part of a group of macrophages names border- associated macrophages (BAM). Most BAM are generated during embryogenesis and maintained by self- division. We developed a genetic system in which the main type of BAM (CD206H) is ablated i...

Research Terms

<Ablation><Acceleration><Adoptive Transfer><Adventitial Cell><Affect><Astrocytes><Astrocytus><Astroglia><Azovan Blue><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><BBB function><BBB permeabilization><BBB permeable><Biotin><Blood - brain barrier anatomy><Blood Vessels><Blood monocyte><Blood-Brain Barrier><Brain><Brain Nervous System><Bypass><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CNS Nervous System><Cell Body><Cells><Central Nervous System><Cervical><Class II Genes><Collaborations><Consensus><Demyelinations><Disease><Disorder><Disseminated Sclerosis><EAE><Embryo Development><Embryogenesis><Embryonic Development><Encephalon><Endothelial Cells><Endothelium><Endowment><Evans Blue><Evans blue stain><Experimental Allergic Encephalitis><Experimental Allergic Encephalomyelitis><Experimental Autoimmune Encephalitis><Experimental Autoimmune Encephalomyelitis><Extravasation><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Genetic><HLA Class II Genes><Health><Hemato-Encephalic Barrier><Hortega cell><Immune><Immune infiltrates><Immune system><Immunes><Impairment><Infiltration><Inflammation><Inflammatory><Inflammatory Infiltrate><Invaded><Kinetics><Label><Leakage><Location><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphatic cell><Lymphatic nodes><Lymphocyte><Lymphocytic><Lymphoid><Lymphoid Cell><MHC Class II><MHC Class II Genes><MR Imaging><MR Tomography><MRI><MRIs><Macrophage><Magnetic Resonance Imaging><Marrow monocyte><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medulla Spinalis><Mice><Mice Mammals><Microglia><Modeling><Monitor><Mouse Strains><Multiple Sclerosis><Murine><Mus><Myelin><Myelogenous><Myeloid><Myeloid Cells><Mφ><NMR Imaging><NMR Tomography><Names><Nerve Cells><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neurons><Nuclear Magnetic Resonance Imaging><Pathogenesis><Pathology><Pericapillary Cell><Pericytes><Perivascular Cell><Phagocytosis><Phenotype><Production><RNA Seq><RNA sequencing><RNAseq><Reaction><Regulatory T-Lymphocyte><Reporter><Role><Rouget Cells><Severities><Spillage><Spinal Cord><Subgroup><System><T cell infiltration><T-Cell Activation><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Testing><Time><Treg><Vitamin H><Zeugmatography><activate T cells><astrocytic glia><autoimmune encephalomyelitis><blood-brain barrier function><blood-brain barrier permeabilization><blood-brain barrier permeable><bloodbrain barrier><bloodbrain barrier function><bloodbrain barrier permeabilization><bloodbrain barrier permeable><coenzyme R><cytokine><demyelinate><draining lymph node><flow cytophotometry><foot><gitter cell><healing><human disease><immune cell infiltrate><insular sclerosis><lymph cell><lymph gland><lymph nodes><lymphnodes><macromolecule><macrophage product><mesoglia><microglial cell><microgliocyte><monocyte><name><named><naming><neural inflammation><neuroinflammation><neuroinflammatory><neuronal><novel><perivascular glial cell><regional lymph node><regulatory T-cells><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><thymus derived lymphocyte><tool><transcriptome sequencing><transcriptomic sequencing><vascular><virtual>
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Miguel Fribourg

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Exploratory lead · 26/100
Solid budget
Active award
$462,000
FY 2026

Project Title

Fab-drug conjugates in transplant

Grant Number:

1R21AI197013-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/4/2026

End Date:

1/31/2028

Project Abstract

SUMMARY Current treatments for the suppression of allograft rejection have remained largely unchanged over the last several decades, relying on systemic calcineurin inhibition, anti-metabolites, and steroids. Although effective in curtailing alloimmune responses, these systemic therapies produce sig...

Research Terms

<(TNF)-α><6-Methylprednisolone><6Alpha-Methylprednisolone><Acids><Address><Adrenal Cortex Hormones><Allografting><Anti-Rejection Therapy><Antibody Specificity><Antibody-drug conjugates><Antigen Binding Fragment><Antiinflammatory Effect><Antimetabolites><Autoimmune Diseases><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Benchmarking><Best Practice Analysis><Binding><Biodistribution><Biological Agent><Biological Products><Blood Serum><Body Tissues><CD3><CD3 Antigens><CD3 Complex><CD3 molecule><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cachectin><Calcineurin><Calcineurin antagonist><Calcineurin inhibitor><Calibration><Cancers><Cardiac Transplantation><Cell Body><Cell Culture Techniques><Cells><Clinic><Corticoids><Corticosteroids><Cytotoxic agent><Cytotoxic drug><Diagnostic><Dose><Drug Delivery><Drug Delivery Systems><Drug Monitoring><Drugs><Ensure><Environment><Fab Fragments><Fab Immunoglobulins><Funding Mechanisms><Future><Grafting Procedure><Granzyme><HPGF><Heart Grafting><Heart Transplantation><Hepatocyte-Stimulating Factor><Histology><Human><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Image><Immunoglobulin, F(ab) Fragment><Immunosuppressants><Immunosuppression><Immunosuppression Effect><Immunosuppressive Agents><Immunosuppressive Effect><Immunosuppressive Therapy><Immunosuppressive drug><Immunosuppressive treatment><In Vitro><Inflammation><Interleukin-6><Label><Life><MGI-2><Macrophage-Derived TNF><Malignant Neoplasms><Malignant Tumor><Mediator><Medication><Methyl prednisolone><Methylprednisolone><Methylprednisolonum><Metipred><Mice><Mice Mammals><Modern Man><Molecular Interaction><Monitor><Monocyte-Derived TNF><Murine><Mus><Mycophenolic Acid><Myeloid Differentiation-Inducing Protein><OKT3 antigen><Opportunistic Infections><Organ><Organ Transplantation><Organ Transplants><Outcome><PK/PD><PP2B><Patients><Penetration><Performance><Pharmaceutical Preparations><Plasmacytoma Growth Factor><Protein Phosphatase-2B><Reaction><SYS-TX><Serum><Site><Steroid Compound><Steroids><Systemic Therapy><T cell response><T-Cell Activation><T-Cells><T-Lymphocyte><T3 Antigens><T3 Complex><T3 molecule><T8 Cells><T8 Lymphocytes><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Tacrolimus><Technology><Testing><Therapeutic><Therapeutic immunosuppression><Time><Tissues><Toxic effect><Toxicities><Transplant Recipients><Transplantation><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><activate T cells><allograft rejection><anti-inflammatory effect><artificial immunosuppression><autoimmune condition><autoimmune disorder><autoimmunity disease><benchmark><biologics><biopharmaceutical><biotherapeutic agent><cardiac graft><cell culture><cell cultures><chemotherapy><cytokine><design><designing><drug/agent><extracellular><fluorophore><heart transplant><high reward><high risk><imaging><immune suppression><immune suppressive activity><immune suppressive agent><immune suppressive function><immune suppressor><immunogenicity><immunosuppression therapy><immunosuppressive activity><immunosuppressive function><immunosuppressive response><immunosuppressive substance><immunosuppressor><improved><innovate><innovation><innovative><interferon beta 2><life span><lifespan><malignancy><mortality><nano therapy><nanotherapy><neoplasm/cancer><organ allograft><organ graft><organ rejection><organ transplant rejection><organ xenograft><pharmacokinetics and pharmacodynamics><pre-clinical study><preclinical study><prevent><preventing><response><side effect><site targeted delivery><small molecule><systemic toxicity><targeted delivery><theranostics><thymus derived lymphocyte><tool><transcriptomics><transplant><transplant model><transplant patient><tumor>
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Francisco Jose Fueyo Gonzalez

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Exploratory lead · 26/100
Solid budget
Active award
$462,000
FY 2026

Project Title

Fab-drug conjugates in transplant

Grant Number:

1R21AI197013-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/4/2026

End Date:

1/31/2028

Project Abstract

SUMMARY Current treatments for the suppression of allograft rejection have remained largely unchanged over the last several decades, relying on systemic calcineurin inhibition, anti-metabolites, and steroids. Although effective in curtailing alloimmune responses, these systemic therapies produce sig...

Research Terms

<(TNF)-α><6-Methylprednisolone><6Alpha-Methylprednisolone><Acids><Address><Adrenal Cortex Hormones><Allografting><Anti-Rejection Therapy><Antibody Specificity><Antibody-drug conjugates><Antigen Binding Fragment><Antiinflammatory Effect><Antimetabolites><Autoimmune Diseases><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Benchmarking><Best Practice Analysis><Binding><Biodistribution><Biological Agent><Biological Products><Blood Serum><Body Tissues><CD3><CD3 Antigens><CD3 Complex><CD3 molecule><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><Cachectin><Calcineurin><Calcineurin antagonist><Calcineurin inhibitor><Calibration><Cancers><Cardiac Transplantation><Cell Body><Cell Culture Techniques><Cells><Clinic><Corticoids><Corticosteroids><Cytotoxic agent><Cytotoxic drug><Diagnostic><Dose><Drug Delivery><Drug Delivery Systems><Drug Monitoring><Drugs><Ensure><Environment><Fab Fragments><Fab Immunoglobulins><Funding Mechanisms><Future><Grafting Procedure><Granzyme><HPGF><Heart Grafting><Heart Transplantation><Hepatocyte-Stimulating Factor><Histology><Human><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Image><Immunoglobulin, F(ab) Fragment><Immunosuppressants><Immunosuppression><Immunosuppression Effect><Immunosuppressive Agents><Immunosuppressive Effect><Immunosuppressive Therapy><Immunosuppressive drug><Immunosuppressive treatment><In Vitro><Inflammation><Interleukin-6><Label><Life><MGI-2><Macrophage-Derived TNF><Malignant Neoplasms><Malignant Tumor><Mediator><Medication><Methyl prednisolone><Methylprednisolone><Methylprednisolonum><Metipred><Mice><Mice Mammals><Modern Man><Molecular Interaction><Monitor><Monocyte-Derived TNF><Murine><Mus><Mycophenolic Acid><Myeloid Differentiation-Inducing Protein><OKT3 antigen><Opportunistic Infections><Organ><Organ Transplantation><Organ Transplants><Outcome><PK/PD><PP2B><Patients><Penetration><Performance><Pharmaceutical Preparations><Plasmacytoma Growth Factor><Protein Phosphatase-2B><Reaction><SYS-TX><Serum><Site><Steroid Compound><Steroids><Systemic Therapy><T cell response><T-Cell Activation><T-Cells><T-Lymphocyte><T3 Antigens><T3 Complex><T3 molecule><T8 Cells><T8 Lymphocytes><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Tacrolimus><Technology><Testing><Therapeutic><Therapeutic immunosuppression><Time><Tissues><Toxic effect><Toxicities><Transplant Recipients><Transplantation><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><activate T cells><allograft rejection><anti-inflammatory effect><artificial immunosuppression><autoimmune condition><autoimmune disorder><autoimmunity disease><benchmark><biologics><biopharmaceutical><biotherapeutic agent><cardiac graft><cell culture><cell cultures><chemotherapy><cytokine><design><designing><drug/agent><extracellular><fluorophore><heart transplant><high reward><high risk><imaging><immune suppression><immune suppressive activity><immune suppressive agent><immune suppressive function><immune suppressor><immunogenicity><immunosuppression therapy><immunosuppressive activity><immunosuppressive function><immunosuppressive response><immunosuppressive substance><immunosuppressor><improved><innovate><innovation><innovative><interferon beta 2><life span><lifespan><malignancy><mortality><nano therapy><nanotherapy><neoplasm/cancer><organ allograft><organ graft><organ rejection><organ transplant rejection><organ xenograft><pharmacokinetics and pharmacodynamics><pre-clinical study><preclinical study><prevent><preventing><response><side effect><site targeted delivery><small molecule><systemic toxicity><targeted delivery><theranostics><thymus derived lymphocyte><tool><transcriptomics><transplant><transplant model><transplant patient><tumor>
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Michael J Sheehan

CORNELL UNIVERSITY, ITHACA, NY

Exploratory lead · 26/100
Solid budget
Active award
$458,871
FY 2026

Project Title

Epigenetic Aging: The Impact of Social and Environmental Realism

Grant Number:

1R21AG093628-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

Correlational studies in human populations strongly indicate that the environment in which we live has a large impact on our health and well-being, including influencing lifespan and relative rates of aging. Increasingly, it is clear that both the physical and social environments in which we are emb...

Research Terms

<Acceleration><Address><Age><Aging><Ammon Horn><Animal Experimental Use><Animal Experimentation><Animal Model><Animal Models and Related Studies><Animal Research><Animals><Assay><Behavior><Behavioral><Behavioral Assay><Bioassay><Biological><Biological Assay><Biology><Blood><Blood Reticuloendothelial System><Body Tissues><Catalogs><Causality><Characteristics><Chronology><Complex><Cornu Ammonis><Correlation Studies><Data><Demography><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Future><Genetic><Genome><Genomics><Grant><GrimAge clock><Hannum clock><Health><Hippocampus><History><Horvath clock><Housing><Human><Hypermethylation><Inbred Mouse><Inbreeding><Laboratories><Length of Life><Link><Liver><Longevity><Mammalia><Mammals><Measurement><Measures><Mediating><Methylation><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Monitor><Murine><Mus><Pattern><Performance><Personal Satisfaction><PhenoAge clocks><Phenotype><Physical environment><Physiologic><Physiological><Population><Process><Recording of previous events><Research><Residual><Residual state><Sampling><Shapes><Site><Skin><Social Environment><Socioeconomic Factors><Standardization><Statistical Correlation><Structure><System><Testing><Tissue Sample><Tissues><Training><Translating><Variant><Variation><Work><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><age associated><age associated alterations><age associated changes><age associated effects><age clock><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age effect><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related effects><age specific><age specific alterations><age specific changes><ages><aging associated alterations><aging associated changes><aging clocks><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging induced epigenetic change><aging related alterations><aging related changes><aging specific alterations><aging specific changes><aging-associated epigenetic change><aging-related epigenetic change><alterations with age><animal experimentations><biologic><catalog><causation><cell type><changes with age><clock measuring biological age><clock measuring biological aging><clock of biological aging><cohort><disease causation><epigenetic age clocks><epigenetic aging><epigenetic clock><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic molecular clocks><epigenetic regulation><epigenetic regulation of aging><epigenetically><epigenomics><experiment><experimental research><experimental study><experiments><faster epigenetic aging><faster rates of epigenetic aging><gene testing><gene-based testing><genetic testing><genome wide methylation><genomewide methylation><global methylation><hepatic body system><hepatic organ system><hippocampal><histories><impact of age><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><influence of age><insight><life span><lifespan><methylation clock><methylome><model of animal><model organism><mouse model><murine model><pace of aging><pace of biological aging><rapid epigenetic aging><rate of aging><rate of biological aging><senescence><senescent><sex><social><social climate><social context><social structural><social structure><socio-economic factors><socio-structural><socioenvironment><socioenvironmental><sociostructural><speed of aging><speed of the aging><tool><well-being><wellbeing>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Wanding Zhou

CORNELL UNIVERSITY, ITHACA, NY

Exploratory lead · 26/100
Solid budget
Active award
$458,871
FY 2026

Project Title

Epigenetic Aging: The Impact of Social and Environmental Realism

Grant Number:

1R21AG093628-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

Correlational studies in human populations strongly indicate that the environment in which we live has a large impact on our health and well-being, including influencing lifespan and relative rates of aging. Increasingly, it is clear that both the physical and social environments in which we are emb...

Research Terms

<Acceleration><Address><Age><Aging><Ammon Horn><Animal Experimental Use><Animal Experimentation><Animal Model><Animal Models and Related Studies><Animal Research><Animals><Assay><Behavior><Behavioral><Behavioral Assay><Bioassay><Biological><Biological Assay><Biology><Blood><Blood Reticuloendothelial System><Body Tissues><Catalogs><Causality><Characteristics><Chronology><Complex><Cornu Ammonis><Correlation Studies><Data><Demography><Environment><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Etiology><Future><Genetic><Genome><Genomics><Grant><GrimAge clock><Hannum clock><Health><Hippocampus><History><Horvath clock><Housing><Human><Hypermethylation><Inbred Mouse><Inbreeding><Laboratories><Length of Life><Link><Liver><Longevity><Mammalia><Mammals><Measurement><Measures><Mediating><Methylation><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Monitor><Murine><Mus><Pattern><Performance><Personal Satisfaction><PhenoAge clocks><Phenotype><Physical environment><Physiologic><Physiological><Population><Process><Recording of previous events><Research><Residual><Residual state><Sampling><Shapes><Site><Skin><Social Environment><Socioeconomic Factors><Standardization><Statistical Correlation><Structure><System><Testing><Tissue Sample><Tissues><Training><Translating><Variant><Variation><Work><accelerated epigenetic age><accelerated epigenetic aging><accelerated pace of epigenetic aging><acceleration in epigenetic age><age associated><age associated alterations><age associated changes><age associated effects><age clock><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age effect><age induced alterations><age induced changes><age linked><age related><age related alterations><age related changes><age related effects><age specific><age specific alterations><age specific changes><ages><aging associated alterations><aging associated changes><aging clocks><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging effect><aging induced alterations><aging induced changes><aging induced epigenetic change><aging related alterations><aging related changes><aging specific alterations><aging specific changes><aging-associated epigenetic change><aging-related epigenetic change><alterations with age><animal experimentations><biologic><catalog><causation><cell type><changes with age><clock measuring biological age><clock measuring biological aging><clock of biological aging><cohort><disease causation><epigenetic age clocks><epigenetic aging><epigenetic clock><epigenetic mechanisms in aging><epigenetic modifications in aging><epigenetic molecular clocks><epigenetic regulation><epigenetic regulation of aging><epigenetically><epigenomics><experiment><experimental research><experimental study><experiments><faster epigenetic aging><faster rates of epigenetic aging><gene testing><gene-based testing><genetic testing><genome wide methylation><genomewide methylation><global methylation><hepatic body system><hepatic organ system><hippocampal><histories><impact of age><increased epigenetic age><increased epigenetic aging><increased rates of epigenetic aging><influence of age><insight><life span><lifespan><methylation clock><methylome><model of animal><model organism><mouse model><murine model><pace of aging><pace of biological aging><rapid epigenetic aging><rate of aging><rate of biological aging><senescence><senescent><sex><social><social climate><social context><social structural><social structure><socio-economic factors><socio-structural><socioenvironment><socioenvironmental><sociostructural><speed of aging><speed of the aging><tool><well-being><wellbeing>
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Nan Yan

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Exploratory lead · 26/100
Solid budget
Active award
$456,500
FY 2026

Project Title

Oligoadenylate synthetase (OAS) in intestinal immunity

Grant Number:

1R21AI191016-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/2/2026

End Date:

1/31/2028

Project Abstract

The oligoadenylate synthetase (OAS) is a family of enzymes that act as RNA sensors in innate immunity. Microbial dsRNA activates OAS synthesis of short linear 2’5’ oligoadenylates, which activate endoribonuclease RNase L, leading to IFN-I signaling and cell death. The antiviral function of the OAS-R...

Research Terms

<Antibiotic Therapy><Antibiotic Treatment><Assay><Autoregulation><Bacteria><Bacterial Infections><Binding><Bioassay><Biological Assay><Biology><Biopsy><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Cell Body><Cell Communication and Signaling><Cell Death><Cell Line><Cell Signaling><CellLine><Cells><Clinical Research><Clinical Study><Colitis><Colon><Communities><Cytoplasm><DNA mutation><Data><Development><Disease><Disorder><Double-Stranded RNA><Endoribonucleases><Enzyme Gene><Enzymes><Epithelial Cells><Family><Foundations><Future><Gene Expression><Gene Family><Genes><Genetic Change><Genetic defect><Genetic mutation><Goals><Grant><Heterozygote><Homeostasis><Human><I-RNA><IFN><Immune><Immunes><Immunity><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Innate Immunity><Interferons><Intestinal><Intestinal Diseases><Intestinal Disorder><Intestines><Intracellular Communication and Signaling><Knock-out><Knockout><Knowledge><Ligase><Ligase Gene><Measures><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Messenger RNA><Mice><Mice Mammals><Modern Man><Molecular Interaction><Murine><Mus><Mutation><Native Immunity><Natural Immunity><Non-Polyadenylated RNA><Non-Specific Immunity><Nonspecific Immunity><Outcome><Pathogenicity><Pathway interactions><Patients><Physiological Homeostasis><Play><Quality Control><RNA><RNA Gene Products><RNA Nucleases><RNA endonuclease><RNase><Reporting><Research><Research Resources><Resources><Ribonuclease Family Protein><Ribonucleases><Ribonucleic Acid><Role><Salmonella><Sampling><Shigella><Signal Transduction><Signal Transduction Systems><Signaling><Source><Strains Cell Lines><Synthetases><Tissues><Type I Interferonopathy><Ulcerated Colitis><Ulcerative Colitis><Variant><Variation><Viral><Viral Activity><Viral Diseases><Viral Function><Viral Physiology><Virus Diseases><analyze microbiome><anti-microbial><antimicrobial><bacteria infection><bacterial disease><bacterial disease treatment><bacterial infectious disease treatment><biological signal transduction><bowel><bowel inflammation><colitis mouse model><colitis murine model><commensal bacteria><commensal bacterial species><cultured cell line><developmental><disease phenotype><dsRNA><early onset><experiment><experimental research><experimental study><experiments><gain of function><genome mutation><gut inflammation><heterozygosity><human data><human disease><immune RNA><inflamed bowel><inflamed gut><inflamed intestine><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><intestinal autoinflammation><intestinal epithelium><intestinal inflammation><intestine disease><intestine disorder><mRNA><microbial><microbiome analysis><monogenic disease><monogenic disorder><mouse colitis><mouse model><murine colitis><murine model><necrocytosis><oligoadenylate><pathway><response><sensor><single-gene disease><single-gene disorder><social role><theories><tool><viral infection><virus infection><virus-induced disease>
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Eric S Huseby

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 26/100
Solid budget
Active award
$454,482
FY 2026

Project Title

Dissecting T Cell Developmental Defects in Down Syndrome

Grant Number:

1R21AI196901-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY / ABSTRACT This MPI R21 proposal directly addresses the objectives of the INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project, emphasizing the creation of innovative biological resources to advance Down syndrome (DS) research. DS...

Research Terms

<Abscission><Address><Age><Amino Acids><Antigen-Antibody Complex><Antigen-Presenting Cells><Apoptosis><Apoptosis Pathway><Assay><Autoantigens><Autoimmune><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Autologous Antigens><Award><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Bioassay><Biological><Biological Assay><Body Tissues><Brittle Diabetes Mellitus><Cardiac><Causality><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Lineage><Cell Signaling><Childhood><Children's Hospital><Chromosome 21><Cities><Clonal Evolution><Collaborations><Complex><Coupled><Data><Data Set><Defect><Development><Disease><Disorder><Down Syndrome><Education><Educational aspects><Ensure><Environment><Etiology><Excision><Extirpation><Face><Female><Future><Generalized Growth><Genes><Genetic><Genetic Polymorphism><Genotype><Goals><Growth><HL-A Antigens><HLA Antigens><Health><Human><Human Chromosomes><Human Leukocyte Antigens><Hyperactivity><IDDM><IFN><Immune><Immune Complex><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immunes><Immunity><Immunologic Diseases><Immunologic Subtyping><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunophenotyping><Individual><Individuals with down syndrome><Infant><Infection><Insulin-Dependent Diabetes Mellitus><Interferons><Intracellular Communication and Signaling><Investigation><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Knowledge><Langdon Down syndrome><Leukocyte Antigens><Link><MHC Receptor><Major Histocompatibility Complex Receptor><Maps><Mature T-Cell><Mature T-Lymphocyte><Mature Thymocyte><Mice><Mice Mammals><Modern Man><Mongolism><Murine><Mus><Nature><Output><Pathology><Pathway interactions><Pediatric Hospitals><Peripheral><Phenotype><Predisposition><Process><Programmed Cell Death><Property><Publishing><Receptor Signaling><Regulatory T-Lymphocyte><Removal><Research><Research Resources><Research Specimen><Resources><Risk><Role><Sampling><Secure><Self Assessment><Self Tolerance><Self-Antigens><Signal Transduction><Signal Transduction Systems><Signaling><Sodium Chloride><Specimen><Stimulus><Sudden-Onset Diabetes Mellitus><Surface><Surgeon><Surgical Removal><Susceptibility><T cell receptor repertoire sequencing><T cell receptor sequencing><T-Cell Antigen Receptors><T-Cell Development><T-Cell Immunodeficiency><T-Cell Ontogeny><T-Cell Receptor><T-Cells><T-Lymphocyte><T-Lymphocyte Development><T-cell receptor repertoire><T1 DM><T1 diabetes><T1D><T1DM><TCR repertoire><TCR repertoire sequencing><TCR sequencing><TCR-seq><TCRseq><Thymic Tissue><Thymus><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Tissue Growth><Tissues><Treg><Trisomy 21><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Vaccination><Y Chromosome><accessory cell><ages><aminoacid><autoimmune condition><autoimmune disorder><autoimmunity disease><autoreactive T cell><biobank><biologic><biological sex><biological signal transduction><biorepository><causation><chromosome 21 trisomy><chromosome 21 trisomy syndrome><cohort><congenital acromicria syndrome><depository><developmental><disease causation><down syndrome individuals><down syndrome patients><experiment><experimental research><experimental study><experiments><faces><facial><follow-up investigation><follow-up research><host response><immune modulatory intervention><immune system response><immunointervention><immunological intervention><immunopathology><immunoresponse><infancy><infantile><infection rate><infection risk><innovate><innovation><innovative><insight><insulin dependent diabetes><insulin dependent type 1><intraepithelial><investigate follow-up><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><life span><lifespan><lymphocyte precursor><lymphocyte progenitor><lymphocyte stem cell><lymphoid precursor><lymphoid progenitors><lymphoid stem cell><male><morbus Down><mouse model><murine model><ontogeny><pathway><patients with down syndrome><pediatric><people with down syndrome><polymorphism><premature><prematurity><progenitor><pseudohypertrophic progressive muscular dystrophy><rate of infection><regulatory T-cells><repository><resection><response><salt><self-reactive T cell><sex determination><social role><study follow-up><survey follow-up><thymocyte><thymus derived lymphocyte><trend><trisomy 21 syndrome><type I diabetes><type one diabetes><♀><♂>
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Wan-Lin Lo

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 26/100
Solid budget
Active award
$454,482
FY 2026

Project Title

Dissecting T Cell Developmental Defects in Down Syndrome

Grant Number:

1R21AI196901-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY / ABSTRACT This MPI R21 proposal directly addresses the objectives of the INvestigation of Co-occurring conditions across the Lifespan to Understand Down syndromE (INCLUDE) Project, emphasizing the creation of innovative biological resources to advance Down syndrome (DS) research. DS...

Research Terms

<Abscission><Address><Age><Amino Acids><Antigen-Antibody Complex><Antigen-Presenting Cells><Apoptosis><Apoptosis Pathway><Assay><Autoantigens><Autoimmune><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Autologous Antigens><Award><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Bioassay><Biological><Biological Assay><Body Tissues><Brittle Diabetes Mellitus><Cardiac><Causality><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Lineage><Cell Signaling><Childhood><Children's Hospital><Chromosome 21><Cities><Clonal Evolution><Collaborations><Complex><Coupled><Data><Data Set><Defect><Development><Disease><Disorder><Down Syndrome><Education><Educational aspects><Ensure><Environment><Etiology><Excision><Extirpation><Face><Female><Future><Generalized Growth><Genes><Genetic><Genetic Polymorphism><Genotype><Goals><Growth><HL-A Antigens><HLA Antigens><Health><Human><Human Chromosomes><Human Leukocyte Antigens><Hyperactivity><IDDM><IFN><Immune><Immune Complex><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immune response><Immunes><Immunity><Immunologic Diseases><Immunologic Subtyping><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Immunophenotyping><Individual><Individuals with down syndrome><Infant><Infection><Insulin-Dependent Diabetes Mellitus><Interferons><Intracellular Communication and Signaling><Investigation><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Knowledge><Langdon Down syndrome><Leukocyte Antigens><Link><MHC Receptor><Major Histocompatibility Complex Receptor><Maps><Mature T-Cell><Mature T-Lymphocyte><Mature Thymocyte><Mice><Mice Mammals><Modern Man><Mongolism><Murine><Mus><Nature><Output><Pathology><Pathway interactions><Pediatric Hospitals><Peripheral><Phenotype><Predisposition><Process><Programmed Cell Death><Property><Publishing><Receptor Signaling><Regulatory T-Lymphocyte><Removal><Research><Research Resources><Research Specimen><Resources><Risk><Role><Sampling><Secure><Self Assessment><Self Tolerance><Self-Antigens><Signal Transduction><Signal Transduction Systems><Signaling><Sodium Chloride><Specimen><Stimulus><Sudden-Onset Diabetes Mellitus><Surface><Surgeon><Surgical Removal><Susceptibility><T cell receptor repertoire sequencing><T cell receptor sequencing><T-Cell Antigen Receptors><T-Cell Development><T-Cell Immunodeficiency><T-Cell Ontogeny><T-Cell Receptor><T-Cells><T-Lymphocyte><T-Lymphocyte Development><T-cell receptor repertoire><T1 DM><T1 diabetes><T1D><T1DM><TCR repertoire><TCR repertoire sequencing><TCR sequencing><TCR-seq><TCRseq><Thymic Tissue><Thymus><Thymus Gland><Thymus Proper><Thymus Reticuloendothelial System><Tissue Growth><Tissues><Treg><Trisomy 21><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Vaccination><Y Chromosome><accessory cell><ages><aminoacid><autoimmune condition><autoimmune disorder><autoimmunity disease><autoreactive T cell><biobank><biologic><biological sex><biological signal transduction><biorepository><causation><chromosome 21 trisomy><chromosome 21 trisomy syndrome><cohort><congenital acromicria syndrome><depository><developmental><disease causation><down syndrome individuals><down syndrome patients><experiment><experimental research><experimental study><experiments><faces><facial><follow-up investigation><follow-up research><host response><immune modulatory intervention><immune system response><immunointervention><immunological intervention><immunopathology><immunoresponse><infancy><infantile><infection rate><infection risk><innovate><innovation><innovative><insight><insulin dependent diabetes><insulin dependent type 1><intraepithelial><investigate follow-up><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><life span><lifespan><lymphocyte precursor><lymphocyte progenitor><lymphocyte stem cell><lymphoid precursor><lymphoid progenitors><lymphoid stem cell><male><morbus Down><mouse model><murine model><ontogeny><pathway><patients with down syndrome><pediatric><people with down syndrome><polymorphism><premature><prematurity><progenitor><pseudohypertrophic progressive muscular dystrophy><rate of infection><regulatory T-cells><repository><resection><response><salt><self-reactive T cell><sex determination><social role><study follow-up><survey follow-up><thymocyte><thymus derived lymphocyte><trend><trisomy 21 syndrome><type I diabetes><type one diabetes><♀><♂>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

JOHN M HAWDON

GEORGE WASHINGTON UNIVERSITY, WASHINGTON, DC

Exploratory lead · 26/100
Solid budget
Active award
$444,125
FY 2026

Project Title

Cross-class selection for anthelmintic resistance in the hookworm Ancylostoma caninum

Grant Number:

1R21AI196592-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/3/2026

End Date:

1/31/2028

Project Abstract

Summary Soil transmitted helminths (STH) are parasitic nematodes that infect over 1 billion people in developing countries. Of the 3 major STH, hookworms are the most virulent, causing anemia and stunting physical and cognitive development in heavily infected people. Currently, morbidity from hookw...

Research Terms

<0-11 years old><Affect><Albendazole><Ancylostoma caninum><Ancylostomatidae><Anemia><Animals><Anthelmintics><Antihelminthic Agent><Antihelminthic Drugs><Area><Behavior><Canine Species><Canis familiaris><Cessation of life><Child><Child Youth><Children (0-21)><DNA mutation><Dangerousness><Death><Detection><Developing Countries><Developing Nations><Development><Dogs><Dogs Mammals><Drug Combinations><Drug Targeting><Drug Therapy><Drug resistance><Drugs><Exploratory/Developmental Grant><Exposure to><Family><Farm Animal><Fenbendazole><Frequencies><Future><Gene Frequency><Generations><Genes><Genetic><Genetic Change><Genetic Markers><Genetic defect><Genetic mutation><Genomics><Goals><Helminths><Hookworm Infections><Hookworms><Human><Individual><Industry><Infection><Knowledge><Lactone Compound><Lactones><Length><Lesion><Less-Developed Countries><Less-Developed Nations><Livestock><Medication><Modern Man><Molecular><Monitor><Morbidity><Multi-Drug Resistance><Multidrug Resistance><Multiple Drug Resistance><Multiple Drug Resistant><Mutation><Natural Resistance><Nature><Output><Parasites><Parasitic Worms><Parasitic nematode><Persons><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phenbendasol><Phenotype><Population><Pyrantel><R21 Mechanism><R21 Program><Race><Races><Research><Resistance><Resistance development><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistant development><Resistant to Multiple Drug><Resistant to multi-drug><Resistant to multidrug><Soil><Testing><Third-World Countries><Third-World Nations><Transmission><Treatment Failure><Tubulin><Under-Developed Countries><Under-Developed Nations><Vermifuges><Virulent><Vulnerable Populations><Zoonoses><Zoonotic><Zoonotic Infection><allelic frequency><antihelminthic><benzimidazole><benzimidazole resistance><benzimidazole resistant><beta Tubulin><biomarker identification><canine><cognitive development><combat><companion dog><developing country><developing nation><developing resistance><developmental><domestic dog><drug intervention><drug resistant><drug treatment><drug/agent><egg><experiment><experimental research><experimental study><experiments><exploratory developmental study><fitness><gene biomarker><gene expression biomarker><gene marker><gene signature biomarker><genetic biomarker><genetic resistance><genome mutation><high reward><high risk><identification of biomarkers><identification of new biomarkers><insight><kids><marker identification><member><milbemycin B><moxidectin><multi-drug resistant><multidrug resistant><naturally resistant><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><offspring><parasitic roundworm><pet animal><pets><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pressure><racial><racial background><racial origin><resistance gene><resistance locus><resistance mechanism><resistance to Drug><resistant><resistant gene><resistant mechanism><resistant to Drug><response to therapy><response to treatment><therapeutic response><therapy failure><therapy response><tool><trait><transmission process><treatment program><treatment response><treatment responsiveness><vulnerable group><vulnerable individual><vulnerable people><youngster><β-Tubulin>
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Damien M O'Halloran

GEORGE WASHINGTON UNIVERSITY, WASHINGTON, DC

Exploratory lead · 26/100
Solid budget
Active award
$444,125
FY 2026

Project Title

Cross-class selection for anthelmintic resistance in the hookworm Ancylostoma caninum

Grant Number:

1R21AI196592-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/3/2026

End Date:

1/31/2028

Project Abstract

Summary Soil transmitted helminths (STH) are parasitic nematodes that infect over 1 billion people in developing countries. Of the 3 major STH, hookworms are the most virulent, causing anemia and stunting physical and cognitive development in heavily infected people. Currently, morbidity from hookw...

Research Terms

<0-11 years old><Affect><Albendazole><Ancylostoma caninum><Ancylostomatidae><Anemia><Animals><Anthelmintics><Antihelminthic Agent><Antihelminthic Drugs><Area><Behavior><Canine Species><Canis familiaris><Cessation of life><Child><Child Youth><Children (0-21)><DNA mutation><Dangerousness><Death><Detection><Developing Countries><Developing Nations><Development><Dogs><Dogs Mammals><Drug Combinations><Drug Targeting><Drug Therapy><Drug resistance><Drugs><Exploratory/Developmental Grant><Exposure to><Family><Farm Animal><Fenbendazole><Frequencies><Future><Gene Frequency><Generations><Genes><Genetic><Genetic Change><Genetic Markers><Genetic defect><Genetic mutation><Genomics><Goals><Helminths><Hookworm Infections><Hookworms><Human><Individual><Industry><Infection><Knowledge><Lactone Compound><Lactones><Length><Lesion><Less-Developed Countries><Less-Developed Nations><Livestock><Medication><Modern Man><Molecular><Monitor><Morbidity><Multi-Drug Resistance><Multidrug Resistance><Multiple Drug Resistance><Multiple Drug Resistant><Mutation><Natural Resistance><Nature><Output><Parasites><Parasitic Worms><Parasitic nematode><Persons><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phenbendasol><Phenotype><Population><Pyrantel><R21 Mechanism><R21 Program><Race><Races><Research><Resistance><Resistance development><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistant development><Resistant to Multiple Drug><Resistant to multi-drug><Resistant to multidrug><Soil><Testing><Third-World Countries><Third-World Nations><Transmission><Treatment Failure><Tubulin><Under-Developed Countries><Under-Developed Nations><Vermifuges><Virulent><Vulnerable Populations><Zoonoses><Zoonotic><Zoonotic Infection><allelic frequency><antihelminthic><benzimidazole><benzimidazole resistance><benzimidazole resistant><beta Tubulin><biomarker identification><canine><cognitive development><combat><companion dog><developing country><developing nation><developing resistance><developmental><domestic dog><drug intervention><drug resistant><drug treatment><drug/agent><egg><experiment><experimental research><experimental study><experiments><exploratory developmental study><fitness><gene biomarker><gene expression biomarker><gene marker><gene signature biomarker><genetic biomarker><genetic resistance><genome mutation><high reward><high risk><identification of biomarkers><identification of new biomarkers><insight><kids><marker identification><member><milbemycin B><moxidectin><multi-drug resistant><multidrug resistant><naturally resistant><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><offspring><parasitic roundworm><pet animal><pets><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pressure><racial><racial background><racial origin><resistance gene><resistance locus><resistance mechanism><resistance to Drug><resistant><resistant gene><resistant mechanism><resistant to Drug><response to therapy><response to treatment><therapeutic response><therapy failure><therapy response><tool><trait><transmission process><treatment program><treatment response><treatment responsiveness><vulnerable group><vulnerable individual><vulnerable people><youngster><β-Tubulin>
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Charles Kyriakos Vorkas

STATE UNIVERSITY NEW YORK STONY BROOK, STONY BROOK, NY

Exploratory lead · 26/100
Solid budget
Active award
$436,605
FY 2026

Project Title

Haemophysalis Longicornis Capacity to Acquire and Transmit Babesia Microti

Grant Number:

1R21AI196576-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/4/2026

End Date:

1/31/2028

Project Abstract

Project Summary/Abstract Babesiosis is caused by the intraerythrocytic Apicomplexan parasite Babesia microti (Bm) and is an emerging vector-borne infection transmitted by the Ixodes scapularis (Is) tick in the U.S. that carries significant morbidity and mortality in elderly and immunocompromised host...

Research Terms

<Academic Medical Centers><Acute><Anemia><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Architecture><Artificial Membranes><Atovoquone><Azadose><Azithromycin><Azitrocin><Azythromycin><B burgdorferi><B. burgdorferi><Babesia><Babesia infection><Babesia microti><Babesia parasite infection><Babesiosis><Biology><Bionomics><Black-legged Tick><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Body Tissues><Borrelia burgdorferi><Borrelia burgdorferi sensu stricto><Borreliella burgdorferi><Causality><Clinical><Communicable Diseases><Coupled><Data><Deer><Deer Tick><Disease><Disorder><Drug resistance><Ecology><Elderly><Engineering / Architecture><Epidemic><Etiology><Future><Genes><Genomic approach><Genomics><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Goals><H longicornis><H. longicornis><Haemaphysalis longicornis><Human><I scapularis><I. scapularis><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><In Vitro><Incidence><Infection><Infectious Diseases><Infectious Disorder><Invaded><Investigators><Ix scalpularis><Ix. scapularis><Ixodes dammini><Ixodes scapularis><Ixodida><Laboratories><Libraries><Long Island><Lyme Borreliosis><Lyme Disease><Lyme Disease Spirochete><Measures><Medical center><Mepron><Methods><Midgut><Miscellaneous Antibiotic><Modern Man><Molecular Epidemiology><Monitor><Morbidity><Nature><Organ><Ovary><Parasitemia><Parasites><Patients><Physicians><Piroplasma><Piroplasmosis><Population Density><Position><Positioning Attribute><Predisposition><Prevalence><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Public Health><Refractory><Reporting><Research><Research Personnel><Research Specimen><Researchers><Resolution><Salivary Glands><Scientist><Seasons><Specimen><Sterility><Structure><Susceptibility><System><Tail><Testing><Therapeutic><Tick Control><Tick-Borne Diseases><Tick-Borne Infections><Ticks><Tissues><Transmission><Ultreon><Universities><University Medical Centers><Wellvone><Zithromax><Zitromax><advanced age><anti-microbial><antimicrobial><atovaquone><bacterial disease treatment><bacterial infectious disease treatment><blacklegged tick><blood meal><causation><chronic symptom><climate change><climatic changes><clinical significance><clinically significant><communicable disease transmission><comparative genomics><controlling ticks><disease causation><disease prevention><disease transmission><disorder prevention><drug resistant><experience><genomic effort><genomic strategy><geographic site><geriatric><global climate change><immunosuppressed patient><in vivo><infected with Babesia><infectious disease transmission><longhorned tick><lyme spirochete><mortality><parasaetemia><pathogen><pathogenic virus><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><persistent symptom><programs><recruit><resistance strain><resistance to Drug><resistant strain><resistant to Drug><resolutions><senior citizen><sterile><success><tick blood feeding><tick blood meal><tick bloodmeal><tick fed><tick feeding><tick imbibes><tick-borne><tick-borne illness><tick-borne pathogen><tickborne><tickborne disease><tickborne illness><tickborne infection><tickborne pathogen><transmission process><uptake><vector><vector control><vector-borne infection><vector-borne pathogen><vectorborne infection><vectorborne pathogen><viral pathogen><virus pathogen>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

KATHLEEN WOULFE

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 26/100
Solid budget
Active award
$429,000
FY 2026

Project Title

Defining the role of decreased estradiol in modulating crotonylation of myofilament proteins in aged female hearts

Grant Number:

1R21AG093397-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY The incidence of diastolic dysfunction increases dramatically in women after menopause, which has long been attributed to loss of protection from female sex hormones, specifically estradiol. The mechanisms underlying estradiol-mediated cardioprotection are still unknown. A better un...

Research Terms

<21+ years old><3-Hydroxyacyl CoA Hydrolyases><3-Hydroxyacyl Dehydratases><Actin Filaments><Adenoviridae><Adenoviruses><Adult><Adult Human><Adult females><Adult women><Age><Age Years><Aquadiol><Basal Transcription Factor><Basal transcription factor genes><Binding><Biochemical Pathway><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiac health><Cardiocyte><CoA><Coenzyme A><Crotonase><Data><Dimenformon><Diogyn><Diogynets><Dysfunction><E1A Binding Protein p300><EP300><EP300 gene><Enoyl Hydrase><Enoyl-CoA Hydratase><Enzyme Gene><Enzymes><Estrace><Estradiol><Estradiol-17 beta><Estradiol-17beta><Estraldine><Female><Females in adulthood><Functional disorder><General Transcription Factor Gene><General Transcription Factors><HDAC><HDAC Proteins><Heart><Heart Muscle Cells><Heart health><Heart myocyte><Histone Deacetylase><Human><Incidence><KAT3B><L-Lysine><Lead><Left Ventricles><Left ventricular structure><Lysine><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Mechanics><Mediating><Mediator><Metabolic Networks><Mice><Mice Mammals><Microfilaments><Modern Man><Modification><Molecular Interaction><Murine><Mus><Myocardial depression><Myocardial dysfunction><Myofibrils><Myofilaments><Na element><Ovocyclin><Ovocylin><Pb element><Physiopathology><Play><Post-Menopause><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Post-menopausal Period><Postmenopausal Period><Postmenopause><Posttranslational Modifications><Posttranslational Protein Processing><Pre-Menopause><Pre-menopausal Period><Premenopausal><Premenopausal Period><Premenopause><Progynon><Protein Modification><Proteins><Recombinants><Relaxation><Role><Safety><Sarcomeres><Sodium><Testing><Therapeutic Estradiol><Transcription Factor Proto-Oncogene><Transcription factor genes><Woman><Women in adulthood><adulthood><after menopause><aged><aged mice><aged mouse><ages><beta-Hydroxyacyl Dehydratases><beta-Hydroxyacyl-CoA Dehydrases><cardiac aging><cardiac dysfunction><cardiac function><cardiomyocyte><cardioprotectant><cardioprotection><cardioprotective><druggable target><elderly mice><experiment><experimental research><experimental study><experiments><female sex hormone><following menopause><function of the heart><heart aging><heart dysfunction><heart function><heavy metal Pb><heavy metal lead><histone acetyltransferase p300><improved><insight><mechanic><mechanical><mortality><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><old mice><p300><past menopause><pathophysiology><post-menopausal><postmenopausal><postmenopausal status><pre-menopausal><premenopausal status><promoter><promotor><protective effect><protein expression><response><social role><therapeutic target><transcription factor><♀>
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HANS HAECKER

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 26/100
Solid budget
Active award
$423,500
FY 2026

Project Title

Development of HTS for discovery of IL-25 inhibitors

Grant Number:

1R21AI189586-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/6/2026

End Date:

1/31/2028

Project Abstract

ABSTRACT Members of the IL-17 family (IL-17A-F) and its cognate receptors (IL-17RA-RE) mediate physiologically important immune responses, however, they can also drive inflammatory diseases, such as allergic asthma in case of IL-25. Despite its emerging clinical need, no drugs against IL-25 or its s...

Research Terms

<Allergic asthma><Assay><Binding><Bioassay><Biological Assay><Biological Response Modifiers><Biomodulators><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Calibration><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cells><Chimera Protein><Chimeric Proteins><Clinical><Complement><Complement Proteins><Complex><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Data><Development><Dimerization><Disadvantaged><Disease><Disorder><Dose><Drug Screening><Drug Targeting><Drug usage><Drugs><Engineering><Environment><Event><Extrinsic asthma><Family><Family member><Fusion Protein><Future><Goals><High Throughput Assay><Human Cell Line><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><Immune Mediators><Immune Mediators/Modulators><Immune response><Inflammatory><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Intracellular Communication and Signaling><Lead><Libraries><Mediating><Medication><Medicinal Chemistry><Molecular Interaction><Mouse Cell Line><Pathway interactions><Pb element><Performance><Pharmaceutic Chemistry><Pharmaceutical Chemistry><Pharmaceutical Preparations><Pharmacology><Phenotype><Physiologic><Physiological><Position><Positioning Attribute><Property><Protein Dimerization><Proteins><Receptor Protein><Reporter><Robot><Screening procedure><Series><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Strains Cell Lines><System><TNF Receptor-Associated Factor 6 Gene><TRAF6><TRAF6 gene><Testing><Time><Variant><Variation><Work><atopic asthma><biological signal transduction><complementation><cultured cell line><design><designing><developmental><drug development><drug discovery><drug use><drug/agent><experience><extrinsic allergic asthma><heavy metal Pb><heavy metal lead><high throughput screening><host response><immune system response><immunoresponse><in vivo><inhibitor><member><mouse model><murine model><pathway><prevent><preventing><receptor><recruit><response><screening><screening tools><screenings><small molecular inhibitor><small molecule><small molecule inhibitor>
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JAMES Edward BINA

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 26/100
Solid budget
Active award
$412,942
FY 2026

Project Title

Regulation of Hypervirulent Klebsiella pneumoniae Virulence by Environmental Signals in the Host

Grant Number:

1R21AI196813-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2026

End Date:

1/31/2028

Project Abstract

Project Summary/Abstract: Hypervirulent Klebsiella pneumoniae (hvKp) poses an urgent public health threat as a cause of severe infections, with growing concern due to emerging multidrug resistance. While intestinal colonization precedes most hvKp infections, the regulatory mechanisms controlling th...

Research Terms

<Address><Adherence><Alimentary Canal><Anabolism><Animals><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Assay><Bacteria><Bile><Bile Juice><Bile fluid><Bioassay><Biological Assay><Capsules><Cell Communication and Signaling><Cell Signaling><Cues><Data><Development><Digestive Tract><Disease><Disorder><Distal><Enterocytes><Environment><Future><GI Tract><GI colonization><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Regulation><Gene Regulation Process><Gene Transcription><Genes><Genetic Transcription><Grant><Human><Infection><Intestinal><Intestines><Intracellular Communication and Signaling><Invaded><K pneumoniae><K. pneumoniae><Klebsiella pneumoniae><Knowledge><Life><Maps><Mediating><Microbial Biofilms><Miscellaneous Antibiotic><Modeling><Modern Man><Molecular><Multi-Drug Resistance><Multidrug Resistance><Multiple Drug Resistance><Multiple Drug Resistant><Pathogenesis><Pathogenicity Factors><Pathway interactions><Phenotype><Pneumonia><Production><Public Health><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Regulation><Regulon><Research><Resistance><Resistance to Multi-drug><Resistance to Multidrug><Resistance to Multiple Drug><Resistance to antibiotics><Resistant to Multiple Drug><Resistant to antibiotics><Resistant to multi-drug><Resistant to multidrug><Role><Sepsis><Signal Transduction><Signal Transduction Systems><Signaling><Systemic infection><Testing><Therapeutic><Transcription><Urinary tract infection><Urinary tract infectious disease><Virulence><Virulence Factors><alimentary tract><antibiotic drug resistance><antibiotic resistant><bile salts><biofilm><biological signal transduction><biosynthesis><bowel><capsule><developmental><digestive canal><disease control><disorder control><experiment><experimental research><experimental study><experiments><gastrointestinal><gastrointestinal tract colonization><genetic approach><genetic strategy><gut colonization><in vivo><intestinal colonization><mortality><multi-drug resistant><multidrug resistant><mutant><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><pathogen><pathogenicity gene><pathway><prevent><preventing><resistant><response><social role><trait><transcriptome sequencing><transcriptomic sequencing><urinary infection><virulence gene><virulent gene>
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Robert T Mankowski

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 26/100
Solid budget
Active award
$409,750
FY 2026

Project Title

Cocoa to maximize exercise training in older adults - COMET Trial

Grant Number:

1R21AG092916-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2026

End Date:

12/31/2027

Project Abstract

Abstract Diminished mitochondrial function, excessive production of reactive oxygen species (ROS) and mitochondrial DNA (mtDNA) damage are key contributors to age-related physical capacity and muscle strength decline. Adaptation to aerobic and strength exercise training is currently one of the most ...

Research Terms

<65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Active Follow-up><Active Oxygen><Adherence><Aerobic><Aerobic Activity><Aerobic Exercise><Aerobic Training><Aerobic fitness><Aged 65 and Over><Biological><Biopsy><Blood Plasma><Blood Sample><Blood specimen><Capsules><Cellulose><Clinical><Clinical Research><Clinical Study><Clinical Trials><Cocoa><Cocoa Powder><Consumption><DNA Damage><DNA Injury><Data><Development><Diet><Dietary History><Education for Intervention><Educational Intervention><Exercise><Exertion><Extensor><Flavanol><Flexor><Future><H2O2><Harvest><Health Care Systems><Heterogeneity><Human><Hydrogen Peroxide><Hydroperoxide><Instruction Intervention><Intervention><Knowledge><Lead><Lower Extremity><Lower Limb><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measurement><Measures><Membrum inferius><Mice><Mice Mammals><Mitochondria><Mitochondrial DNA><Mobility disability><Modern Man><Murine><Mus><Muscle><Muscle Fatigue><Muscle Fibers><Muscle Mitochondria><Muscle Tissue><Muscular Fatigue><Myotubes><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Nutraceutical><Outcome><Oxidative Stress><Oxygen Radicals><Participant><Patients><Pb element><Performance><Peripheral arterial disease><Permeability><Phase 3 Clinical Trials><Phase III Clinical Trials><Physical Capacity><Physical Function><Physical Performance><Placebos><Plasma><Plasma Serum><Polyanhydroglucuronic Acid><Pre-Clinical Model><Preclinical Models><Pro-Oxidants><Production><Questionnaires><Randomized><Reactive Oxygen Species><Regimen><Resistance><Respiration><Reticuloendothelial System, Serum, Plasma><Rhabdomyocyte><Risk><Sarcosomes><Sham Treatment><Skeletal Fiber><Skeletal Muscle><Skeletal Muscle Cell><Skeletal Muscle Fiber><Skeletal Myocytes><Structure><Supplementation><Testing><Training Intervention><Visit><Voluntary Muscle><Walking><above age 65><active followup><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age associated><age correlated><age dependent><age linked><age of 65 years onward><age related><age specific><aged 65 and greater><aged 65+><aged ≥65><alpha-Cellulose><anti-oxidant enzyme><antioxidant enzyme><biologic><capsule><cardiometabolic><cardiometabolism><care giving><caregiving><co-morbid><co-morbidity><comorbidity><decreased muscle strength><developmental><diet history><diets><dynapenia><enzyme activity><epicatechin><exercise training><follow up><follow-up><followed up><followup><heavy metal Pb><heavy metal lead><human old age (65+)><improved><instructional intervention><low muscle strength><mid life><mid-life><middle age><middle aged><midlife><mitochondrial><mitochondrial dysfunction><mtDNA><muscle strength><muscle strength decline><muscular><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><old age><older adult><older adulthood><over 65 years><performance in walking><peripheral artery disease><phase III protocol><pilot trial><pre-clinical study><preclinical study><preservation><primary outcome><randomisation><randomization><randomly assigned><reduced muscle strength><resistance exercise><resistance training><resistant><respiratory mechanism><satisfaction><secondary outcome><sham therapy><success><therapeutic target><ultrasound><vastus lateralis><walking pace><walking performance><walking speed><≥65 years>
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Xiaorong Lin

UNIVERSITY OF GEORGIA, ATHENS, GA

Exploratory lead · 26/100
Solid budget
Active award
$400,932
FY 2026

Project Title

Immunity induced by cryptococcal morphological strains in CD4+ T cell-deficient hosts

Grant Number:

1R21AI195147-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/2/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Cryptococcal meningoencephalitis (CME) is responsible for more than 15% of the total deaths of AIDS patients. The disease claims hundreds of thousands of lives each year, with global mortality rates of ~70% de- spite antifungal therapies. Unfortunately, there is no vaccine clinicall...

Research Terms

<AIDS><AIDS patients><AIDS/HIV><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immunodeficiency Syndrome><Adjuvant><Advanced HIV><Animals><Antibodies><Antifungal Therapy><Antigens><Attenuated><B cell growth factor><B-Cell Differentiation Factor-1><B-Cell Growth Factor-1><B-Cell Growth Factor-I><B-Cell Proliferating Factor><B-Cell Stimulating Factor><B-Cell Stimulating Factor-1><B-Cell Stimulation Factor-1><B-Cell Stimulatory Factor-1><BCDF-1><BCGF><BCGF-1><BCSF 1><BSF-1><BSF1><Basal Transcription Factor><Basal transcription factor genes><Binetrakin><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><C neoformans><C. neoformans><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cell Body><Cell Count><Cell Function><Cell Number><Cell Physiology><Cell Process><Cell Protection><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cerebromeningitis><Cessation of life><Clinical><Clinical Trials><Complement><Complement Proteins><Cryptococcosis><Cryptococcus><Cryptococcus neoformans><Cytoprotection><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Data><Death><Death Rate><Disease><Disorder><Drops><Encephalomeningitis><Exploratory/Developmental Grant><Filament><Fungus Diseases><Future><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genetic><Goals><Growth><HIV individuals><HIV infected individuals><HIV infected persons><HIV people><HIV positive individuals><HIV positive people><HIV/AIDS><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL-4><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><IL4 Protein><Immune><Immune Interferon><Immunes><Immunity><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><Individual><Infection><Interferon Gamma><Interferon Type II><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Interleukin-4><Interleukin-4 Precursor><Knowledge><Lymphocyte Stimulatory Factor 1><Lymphoid Cell><MCGF-2><Macrophage><Macrophage Activation><Marrow Neutrophil><Mast Cell Growth Factor-2><Mediating><Meningoencephalitis><Mice><Mice Mammals><Modeling><Morphology><Murine><Mus><Mycoses><Myeloid Cells><Mφ><Nature><Neutrophil Infiltration><Neutrophil Recruitment><Neutrophilic Granulocyte><Neutrophilic Infiltrate><Neutrophilic Leukocyte><Nucleic Acid Vaccines><Opportunistic Infections><PLWH><PWH><Pathogenicity><Patients><Phagocytes><Phagocytic Cell><Phagocytosis><Phase><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Predisposition><Protein Subunits><Public Health><R21 Mechanism><R21 Program><Research><Research Design><Risk><Severe HIV Disease><Stimulus><Study Type><Subcellular Process><Susceptibility><T-Cell Depletion><T-Cell Growth Factor 2><T-cell depletion therapy><T-lymphocyte depletion therapy><T4 Cells><T4 Lymphocytes><Testing><Th-2 Cell><Th2 Cells><Time><Tissue Growth><Torula><Torulosis><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activator/Coactivator><Type 2 Helper Cell><Vaccinated><Vaccination><Vaccination acquired immunity><Vaccination induced immunity><Vaccine Design><Vaccines><Virulence><Virulent><Vulnerable Populations><Work><Yeasts><access to vaccination><access to vaccines><acquired immunodeficiency syndrome patient><amebocyte><attenuate><attenuates><cell type><complementation><critical period><cytokine><cytoprotective><design><designing><develop a vaccine><develop vaccines><development of a vaccine><exploratory developmental study><fungal infection><fungal infectious disease treatment><fungal pathogen><fungi pathogen><fungus><fungus infection><hypoimmunity><immune deficiency><immunodeficiency><immunogen><immunosuppressed patient><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><lFN-Gamma><microbicidal><microbicide><mortality rate><mouse model><murine model><mutant><neutrophil><nucleic acid-based vaccine><ontogeny><overexpress><overexpression><pathogen><pathogenic fungus><patients infected with AIDS><patients with AIDS><patients with acquired immunodeficiency syndrome><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><pre-clinical study><preclinical study><prevent><preventing><response><study design><transcription factor><vaccination access><vaccination availability><vaccine access><vaccine acquired immunity><vaccine associated immunity><vaccine availability><vaccine development><vaccine-induced immunity><vaccine-induced protection><vulnerable group><vulnerable individual><vulnerable people>
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Wendy T Watford

UNIVERSITY OF GEORGIA, ATHENS, GA

Exploratory lead · 26/100
Solid budget
Active award
$400,932
FY 2026

Project Title

Immunity induced by cryptococcal morphological strains in CD4+ T cell-deficient hosts

Grant Number:

1R21AI195147-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/2/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Cryptococcal meningoencephalitis (CME) is responsible for more than 15% of the total deaths of AIDS patients. The disease claims hundreds of thousands of lives each year, with global mortality rates of ~70% de- spite antifungal therapies. Unfortunately, there is no vaccine clinicall...

Research Terms

<AIDS><AIDS patients><AIDS/HIV><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immunodeficiency Syndrome><Adjuvant><Advanced HIV><Animals><Antibodies><Antifungal Therapy><Antigens><Attenuated><B cell growth factor><B-Cell Differentiation Factor-1><B-Cell Growth Factor-1><B-Cell Growth Factor-I><B-Cell Proliferating Factor><B-Cell Stimulating Factor><B-Cell Stimulating Factor-1><B-Cell Stimulation Factor-1><B-Cell Stimulatory Factor-1><BCDF-1><BCGF><BCGF-1><BCSF 1><BSF-1><BSF1><Basal Transcription Factor><Basal transcription factor genes><Binetrakin><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><C neoformans><C. neoformans><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CTLA-8><CTLA-8 Gene><CTLA8><CTLA8 Gene><Cell Body><Cell Count><Cell Function><Cell Number><Cell Physiology><Cell Process><Cell Protection><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cerebromeningitis><Cessation of life><Clinical><Clinical Trials><Complement><Complement Proteins><Cryptococcosis><Cryptococcus><Cryptococcus neoformans><Cytoprotection><Cytotoxic T-Lymphocyte-Associated Antigen 8><Cytotoxic T-Lymphocyte-Associated Antigen 8 Gene><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8><Cytotoxic T-Lymphocyte-Associated Serine Esterase 8 Gene><Data><Death><Death Rate><Disease><Disorder><Drops><Encephalomeningitis><Exploratory/Developmental Grant><Filament><Fungus Diseases><Future><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genetic><Goals><Growth><HIV individuals><HIV infected individuals><HIV infected persons><HIV people><HIV positive individuals><HIV positive people><HIV/AIDS><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><IL-17><IL-17 Gene><IL-17A><IL-17A Gene><IL-4><IL17><IL17 Protein><IL17 gene><IL17A><IL17A Gene><IL4 Protein><Immune><Immune Interferon><Immunes><Immunity><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><Individual><Infection><Interferon Gamma><Interferon Type II><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8)><Interleukin 17 (Cytotoxic T-Lymphocyte-Associated Serine Esterase 8) Gene><Interleukin 17 Precursor><Interleukin 17 Precursor Gene><Interleukin-17><Interleukin-4><Interleukin-4 Precursor><Knowledge><Lymphocyte Stimulatory Factor 1><Lymphoid Cell><MCGF-2><Macrophage><Macrophage Activation><Marrow Neutrophil><Mast Cell Growth Factor-2><Mediating><Meningoencephalitis><Mice><Mice Mammals><Modeling><Morphology><Murine><Mus><Mycoses><Myeloid Cells><Mφ><Nature><Neutrophil Infiltration><Neutrophil Recruitment><Neutrophilic Granulocyte><Neutrophilic Infiltrate><Neutrophilic Leukocyte><Nucleic Acid Vaccines><Opportunistic Infections><PLWH><PWH><Pathogenicity><Patients><Phagocytes><Phagocytic Cell><Phagocytosis><Phase><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Predisposition><Protein Subunits><Public Health><R21 Mechanism><R21 Program><Research><Research Design><Risk><Severe HIV Disease><Stimulus><Study Type><Subcellular Process><Susceptibility><T-Cell Depletion><T-Cell Growth Factor 2><T-cell depletion therapy><T-lymphocyte depletion therapy><T4 Cells><T4 Lymphocytes><Testing><Th-2 Cell><Th2 Cells><Time><Tissue Growth><Torula><Torulosis><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Activator/Coactivator><Type 2 Helper Cell><Vaccinated><Vaccination><Vaccination acquired immunity><Vaccination induced immunity><Vaccine Design><Vaccines><Virulence><Virulent><Vulnerable Populations><Work><Yeasts><access to vaccination><access to vaccines><acquired immunodeficiency syndrome patient><amebocyte><attenuate><attenuates><cell type><complementation><critical period><cytokine><cytoprotective><design><designing><develop a vaccine><develop vaccines><development of a vaccine><exploratory developmental study><fungal infection><fungal infectious disease treatment><fungal pathogen><fungi pathogen><fungus><fungus infection><hypoimmunity><immune deficiency><immunodeficiency><immunogen><immunosuppressed patient><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><lFN-Gamma><microbicidal><microbicide><mortality rate><mouse model><murine model><mutant><neutrophil><nucleic acid-based vaccine><ontogeny><overexpress><overexpression><pathogen><pathogenic fungus><patients infected with AIDS><patients with AIDS><patients with acquired immunodeficiency syndrome><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><pre-clinical study><preclinical study><prevent><preventing><response><study design><transcription factor><vaccination access><vaccination availability><vaccine access><vaccine acquired immunity><vaccine associated immunity><vaccine availability><vaccine development><vaccine-induced immunity><vaccine-induced protection><vulnerable group><vulnerable individual><vulnerable people>
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Ryan Michael Drenan

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Exploratory lead · 26/100
Solid budget
Active award
$380,460
FY 2026

Project Title

Cholinergic mechanisms of cocaine reinforcement probed with nicotinic receptor gene editing

Grant Number:

5R33DA054819-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2022

End Date:

11/30/2027

Project Abstract

PROJECT SUMMARY Cocaine use disorder represents a major public health challenge, and novel treatment approaches are urgently needed. Tobacco usage is highly co-morbid with cocaine use disorder, and at present, it is not known whether/how nicotinic signal transduction modulates the brain's response t...

Research Terms

<2-photon><4-Aminobutanoic Acid><4-Aminobutyric Acid><4-amino-butanoic acid><AAV vector><AAV-based vector><Acute><Aminalon><Aminalone><Anatomic Sites><Anatomic structures><Anatomy><Automobile Driving><Behavior><Behavioral><Behavioral Assay><Behavioral Genetics><Biologic Models><Biological Models><Body Tissues><Brain><Brain Nervous System><CRISPR><CRISPR/Cas system><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Assay><Clustered Regularly Interspaced Short Palindromic Repeats><Cocaine><Cocaine Abuse><Cocaine Addiction><Cocaine Dependence><Cocaine Users><Cocaine use disorder><Common Rat Strains><Coupled><Detection><Development><Dopamine><Dose><Drugs><Economics><Electrophysiology><Electrophysiology (science)><Encephalon><Female><Fiber><Fostering><Funding><GABA><GWA study><GWAS><Genes><Genetic Determinants of Behavior><Genetic Polymorphism><Genome><Goals><Health><Hydroxytyramine><Individual><Intake><Intracellular Communication and Signaling><Intravenous><Investigation><Kinetics><Knock-out><Knockout><Knowledge><Laser Scanning Microscopy><Learning><Link><Location><Mediating><Medication><Methods><Model System><Modeling><Molecular><Motivation><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neuropharmacology><Neurophysiology / Electrophysiology><Nicotinic Acetylcholine Receptors><Nicotinic Receptors><Optical Methods><Outcome><Pharmaceutical Preparations><Pharmacology><Phase><Phenotype><Photometry><Physiology><Play><Preclinical data><Psychological reinforcement><Public Health><Qualifying><Rat><Rats Mammals><Rattus><Receptor Activation><Receptor Cell><Receptor Gene><Reinforcement><Research><Rewards><Risk><Rodent><Rodentia><Rodents Mammals><Role><Self Administered><Self Administration><Signal Transduction><Signal Transduction Systems><Signaling><Slice><Smoke><Substance Use Disorder><Testing><Therapeutic><Tissues><Tobacco><Tobacco Consumption><Tobacco Dependence><Tobacco use><Upregulation><Validation><Variant><Variation><Ventral Tegmental Area><Work><addicted to cocaine><addiction to cocaine><adeno-associated viral vector><adeno-associated virus vector><attenuation><behavior genetics><behavioral pharmacology><beta2 nicotinic acetylcholine receptor><biological signal transduction><biophysical approaches><biophysical methodology><biophysical methods><biophysical techniques><cell assay><cell type><cholinergic><cigarette smoking><cigarette use><co-morbid><co-morbidity><cocaine addicted><cocaine exposure><cocaine self-administration><cocaine use><cocaine-exposed><comorbidity><developmental><driving><drug/agent><economic><electrophysiological><experiment><experimental research><experimental study><experiments><exposed to cocaine><exposure to cocaine><gain of function><gamma-Aminobutyric Acid><genome editing><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic editing><improved><in vivo><innovate><innovation><innovative><insight><knock-down><knockdown><male><neurobiological mechanism><neuronal><new approaches><nicotinic acetylcholine beta-2 receptor><nicotinic acetylcholine β-2 receptor><nicotinic receptor beta2><nicotinic receptor β2><non-smoker><nonsmoker><novel><novel approaches><novel strategies><novel strategy><optogenetics><patch clamp><pharmacobehavioral><polymorphism><pre-clinical><preclinical><preclinical findings><preclinical information><programs><receptor function><response><self-administer cocaine><social role><substance use and disorder><success><tobacco addiction><tobacco dependent><tobacco product use><tool><treatment strategy><two-photon><validations><ventral tegmentum><whole genome association analysis><whole genome association study><β2 nicotinic acetylcholine receptor><γ-Aminobutyric Acid><♀><♂>
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XU FENG

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 26/100
Solid budget
Active award
$275,124
FY 2026

Project Title

RANK Signaling Inhibitors for Osteolytic Lesions in Multiple Myeloma

Grant Number:

5R21CA296500-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

Project Summary Multiple myeloma patients often develop bone lesions, resulting in poor prognosis and skeletal-related events (SREs, including hypercalcemia, spinal cord compression, vertebral collapse, pathologic fractures and bone pain). Bone lesions in multiple myeloma patients are caused by incr...

Research Terms

<Address><Animal Model><Animal Models and Related Studies><Assay><BM Stem Cell><BM derived progenitor><BM progenitor><BM- derived Stem Cells><Binding><Bioassay><Biological Agent><Biological Assay><Biological Products><Bisphosphonates><Blood monocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><Bone Marrow Stem Cell><Bone Marrow progenitor><Bone Pain><Bone necrosis><CD115 Antigens><CSF-1 Receptor><CSF-1-R><CSF1R Gene Product><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cells><Chemicals><Clinical Treatment Moab><Clinical Trials><Colony Stimulating Factor 1 Receptor><Compressive Myelopathy><Cytoplasmic Domain><Cytoplasmic Tail><DNA mutation><Data><Development><Docking><Drug Targeting><Drugs><Endothelial Cells><Extracellular Signal-Regulated Kinase Gene><Femoral Fractures><Foundations><Fracture><Funding><Future><Genetic Change><Genetic defect><Genetic mutation><Goals><High Throughput Assay><Hu-mABs><Hypercalcemia><Immune><Immune system><Immunes><Impairment><In Vitro><Infection><Injections><Intracellular Communication and Signaling><Jaw><KI mice><Knock-in Mouse><Lesion><Life><Lytic Metastatic Lesion><M-CSF Receptors><MAP Kinase Gene><MAPK><Macrophage><Macrophage Colony Stimulating Factor I Receptor><Macrophage Colony-Stimulating Factor Receptor><Marrow monocyte><Mediating><Medication><Medicinal Chemistry><Methods><Mice><Mice Mammals><Mitogen-Activated Protein Kinase Gene><Modeling><Molecular Interaction><Monoclonal Antibodies><Multiple Myeloma><Murine><Mus><Mutation><Mφ><NIH><National Institutes of Health><ODF factor><OPGL protein><Osteoclast Differentiation Factor><Osteoclasts><Osteolytic><Osteolytic Lesion><Osteonecrosis><Osteoporosis><Osteoprotegerin Ligand><Outcome><Pathologic Fracture><Pathological fracture><Pathway interactions><Patients><Pharmaceutic Chemistry><Pharmaceutical Chemistry><Pharmaceutical Preparations><Phase 3 Clinical Trials><Phase III Clinical Trials><Plasma-Cell Myeloma><Play><Prognosis><Property><Proteins><Proto-Oncogene Protein fms><Public Health><RANK ligand><Receptor Activator of Nuclear Factor Kappa B Ligand><Receptor Protein><Research><Risk><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><Series><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Solid><Spontaneous Fractures><Study models><System><T-Cells><T-Lymphocyte><TNF-Related Activation-Induced Cytokine><TRANCE protein><Tumor Necrosis Factor Ligand Superfamily Member 11><United States National Institutes of Health><Vertebrae><Vertebral><Work><biological signal transduction><biologics><biopharmaceutical><biotherapeutic agent><biphosphonate><bisphosphonate><bone><bone fracture><bone marrow derived progenitor><bone marrow derived stem cells><bone marrow stromal cell><bone marrow stromal stem cell><c-fms Protein><cellular differentiation><cost><counterscreen><developmental><diphosphonate><drug/agent><enhancing factor><femur fracture><genome mutation><high throughput screening><humAbs><human mAbs><human monoclonal antibodies><human monoclonals><immune system function><improved><in vivo><inhibitor><knockin mice><mAbs><model of animal><monoclonal Abs><monocyte><mouse model><murine model><myeloma><myelomatosis><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapy approach><novel therapy target><osteoclastogenesis><pathway><phase III protocol><prevent><preventing><receptor><side effect><skeletal-related events><small molecule><social role><spinal cord compression><spine bone structure><therapeutic target><thymus derived lymphocyte>
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WILLIAM M GEISLER

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 24/100
Active award
Career award
$151,812
FY 2026

Project Title

Midcareer Mentoring Award for Patient-Oriented Research in Chlamydia trachomatis Infection

Grant Number:

5K24AI125685-09

Activity Code:

K24

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

6/1/2016

End Date:

10/31/2027

Project Abstract

Modified Project Summary/Abstract Section This application is for a renewal of my K24 Midcareer Investigator Award in Patient-Oriented Research (POR) on Chlamydia trachomatis (CT) Infections. I, Dr. William Geisler, am a federally funded physician scientist at the University of Alabama at Birmingham...

Research Terms

<16 year old><16 years of age><18 year old><18 years of age><A vaginae><A. vaginae><Address><Adolescent><Adolescent Youth><Affect><Alabama><Antibodies><Antigens><Area><Atopobium vaginae><Award><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Serum><C trachomatis><C. trachomatis><Chlamydia><Chlamydia trachomatis><Clinic><Clinical Investigator><DNA><Deoxyribonucleic Acid><Development><Disparities><Disparity><Doctor of Medicine><ELISA><Education><Educational aspects><Educational process of instructing><Enrollment><Entrepreneurial Skill><Entrepreneurship><Enzyme-Linked Immunosorbent Assay><Female><Frequencies><Funding><Genital Organs><Genitalia><Goals><Gynecology><HIV risk><HLA-DC><HLA-DC Antigens><HLA-DQ><HLA-DQ Antigens><HLA-DQB1><HLA-DQB1 antigen><HLA-DQbeta1><HLA-DS><HLA-DS Antigens><HLA-LB><HLA-LB Antigens><HLA-MB><HLA-MB Antigens><Health><IFN><Immunity><Immunogenetics><Infection><Infection Control><Infection prevention><Interferons><International><Interview><Investigators><K24 Award><K24 Mechanism><K24 Program><Knowledge><Leadership><Linkage Disequilibrium><M.D.><M.P.H.><Master of Public Health><Mediating><Mentors><Mentorship><MicroRNAs><Mid-Career Clinical Scientist Award (K24)><Midcareer Investigator Award in Patient-Oriented Research><Midcareer Investigator Award in Patient-Oriented Research (K24)><Miyagawanella><Mucosa><Mucosal Tissue><Mucous Membrane><NIH><National Institutes of Health><Patients><Physicians><Population><Position><Positioning Attribute><Prevent infection><Prevention><Public Health><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><Reporting><Research><Research Activity><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Specimen><Researchers><Respondent><Rickettsia trachomae><Risk><Risk Marker><Scientific Publication><Scientist><Secure><Serum><Source><Specimen><Students><Survey Instrument><Surveys><Swab><T cell response><T-Cells><T-Lymphocyte><TL1><TNF Ligand-Related Molecule 1><TNF15><TNFSF15><TNFSF15 gene><Teaching><Testing><Time><Training><Translating><Tumor Necrosis Factor Ligand Superfamily Member 15><United States National Institutes of Health><Universities><VEGI><Vaccines><Variant><Variation><Vascular Endothelial Growth Inhibitor><Visit><Woman><access to vaccination><access to vaccines><age 16><age 16 years><age 18><age 18 years><antigen based test><antigen test><bedsonia><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><bio-markers><biologic marker><biomarker><career><career development><chlamydia vaccine><clinical practice><commercialization><design><designing><develop a vaccine><develop vaccines><development of a vaccine><developmental><early experience><eighteen year old><eighteen years of age><enroll><enzyme linked immunoassay><experience><immunogen><immunogenic><improved><infection rate><infection risk><insight><interest><juvenile><juvenile human><male><miRNA><patient oriented research><patient oriented study><patient population><perinatal morbidity><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><programs><public health relevance><rate of infection><recruit><reproductive><reproductive morbidity><research study><response><risk predictor><risk predictors><sample collection><screening><screenings><sixteen year old><sixteen years of age><skill acquisition><skill development><skills><specimen collection><success><thymus derived lymphocyte><vaccination access><vaccination availability><vaccine access><vaccine availability><vaccine candidate><vaccine development><young woman><♀><♂>
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ELAN Z EISENMESSER

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 22/100
Recent
Active award
$234,000
FY 2026

Project Title

Streptococcus pneumoniae HtrA and its target interactions

Grant Number:

5R21AI190731-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Project Abstract

PROJECT SUMMARY High temperature requirement A (HtrA) enzymes represent a diverse family of serine proteases found across prokaryotes and eukaryotes that are critical for cellular homeostasis. In pathogenic bacteria, these enzymes are also shed from membranes after their N-terminal anchoring domain...

Research Terms

<Active Sites><Address><Autoregulation><Binding><Biochemical><Biological><Caseins><Cell Body><Cells><Complex><Cryo-electron Microscopy><Cryoelectron Microscopy><Crystallization><D pneumoniae><D. pneumoniae><DNA mutation><Diplococcus pneumoniae><Disease><Disorder><Drug Targeting><Electron Cryomicroscopy><Enzyme Gene><Enzymes><Equilibrium><Eukaryota><Eukaryote><Exhibits><Family><Family member><Genetic Change><Genetic defect><Genetic mutation><Gram-Positive Bacteria><High temperature of physical object><Homeostasis><Infection><Membrane><Methods><Modeling><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Mutation><N-terminal><NH2-terminal><Nature><Oranges><Pathogenicity><Pathogenicity Factors><Phylogenetic Analysis><Phylogenetics><Physiological Homeostasis><Pneumococcus><Pneumonia><Position><Positioning Attribute><Process><Prokaryotae><Prokaryotic Cells><Protease Domain><Proteolytic Domain><Relaxation><Research><S pneumoniae><S. pneumoniae><Sampling><Serine Endopeptidases><Serine Protease><Serine Protein Hydrolases><Serine Proteinases><Streptococcus pneumoniae><Structural Models><Structure><Time><Vaccines><Virulence Factors><World Health Organization><anti-microbial><antimicrobial><bacteria pathogen><bacterial pathogen><balance><balance function><beta-Casein><biologic><conformation><conformational><conformational state><conformationally><conformations><cryo-EM><cryoEM><cryogenic electron microscopy><density><experiment><experimental research><experimental study><experiments><genome mutation><global health><high temperature><inhibitor><member><membrane structure><monomer><mutant><pathogenic bacteria><priority pathogen><prokaryote><success><β-Casein>
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SETH S MARGOLIS

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 22/100
Recent
Active award
$232,938
FY 2026

Project Title

Generating Critical Knowledge on the NMP Peptide Signaling in the Peripheral Nervous System

Grant Number:

1R21NS147193-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/17/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY This new R21 application focuses on extending our work on the neuronal membrane proteasome derived peptides (NMP-peptides)1-7 and their link to peripheral neuron crosstalk and regulation. In this proposal, we present new data describing NMP-peptides presence and function on DRG neuro...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><Acute><Afferent Neurons><Amino Acids><Animals><Anti-Cancer Agents><Antineoplastic Agents><Antineoplastic Drugs><Antineoplastics><Applications Grants><Area><Automobile Driving><Behavior><Biochemical><Biology><CNS Nervous System><Calcium><Calcium Ion Signaling><Calcium Signaling><Cancer Drug><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cell membrane><Cells><Central Nervous System><Classification><Communities><Cytoplasmic Membrane><Data><Disease><Disorder><Foundations><Funding><Future><Gene Activation><Gene Expression><Gene Transcription><Genetic Transcription><Goals><Grant Proposals><Health><Health system><Image><Individual><Intracellular Communication and Signaling><Investigation><Investigators><Itching><Knowledge><Learning><Link><Macropain><Macroxyproteinase><Measures><Mediating><Membrane><Mice><Mice Mammals><Multicatalytic Proteinase><Murine><Mus><N Methyl D aspartic Acid><N methyl D aspartate><N-Methyl-D-aspartate><N-Methylaspartate><NMDA><Neoplastic Disease Chemotherapeutic Agents><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Nervous System><Nervous System Physiology><Neural Cell><Neuraxis><Neurocyte><Neurologic Body System><Neurologic Organ System><Neurologic function><Neurological function><Neuronal Transmission><Neurons><Neurosciences><Nucleus><Outcome><PNS Diseases><Pain><Painful><Peptide Signal Sequences><Peptides><Peripheral><Peripheral Nerve Diseases><Peripheral Nervous System><Peripheral Nervous System Diseases><Peripheral Nervous System Disorders><Peripheral Neuropathy><Plasma Membrane><Population Heterogeneity><Production><Prosome><Proteasome><Proteasome Endopeptidase Complex><Proteins><Proteomics><Proteosome><Protocol><Protocols documentation><Pruritic Disorder><Pruritis><Pruritus><Publishing><RNA Expression><Receptor Protein><Regulation><Research><Research Personnel><Researchers><Role><Sensory><Sensory Neurons><Sensory Process><Signal Peptide><Signal Sequences><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Stimulus><Systematics><Systems Biology><Testing><Touch><Touch sensation><Transcription><Tumor-Specific Treatment Agents><Velcade><Work><aminoacid><anti-cancer drug><axon signaling><axon-glial signaling><axonal signaling><biological signal transduction><cell type><chronic pain><design><designing><diverse populations><driving><experiment><experimental research><experimental study><experiments><extracellular><glia signaling><glial signaling><heterogeneous population><imaging><improved><in vivo><insight><itch sensation><membrane structure><multicatalytic endopeptidase complex><nerve signaling><nervous system function><neural signaling><neuronal><neuronal signaling><neuropathologic><neuropathological><neuropathology><neurotransmission><novel><peptide aminoacid sequence><peptide sequence><perceptual stimulus><physicochemical phenomena related to the senses><plasmalemma><population diversity><programs><protein aminoacid sequence><protein signal sequence><receptor><response><scRNA sequencing><scRNA-seq><sensory stimulus><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><somatosensory><success><tactile sensation><tool>
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Kaisu Marja Lankinen

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 22/100
Recent
Active award
$208,750
FY 2026

Project Title

Role of connectivity between hippocampus and auditory cortex in adverse listening conditions

Grant Number:

5R21DC021766-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2028

Project Abstract

This project investigates the role of the hippocampus (HC) in adverse listening conditions in human subjects using high resolution 7 Tesla functional magnetic resonance imaging (fMRI). Although HC has traditionally been studied predominantly as a visuospatial processor, evidence is emerging that it ...

Research Terms

<AD dementia><AD risk><AD risk factor><Address><Age related pathologies><Aging><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease risk><Alzheimers Dementia><Ammon Horn><Anatomic Sites><Anatomic structures><Anatomy><Audiology><Auditory><Auditory Cortex><Auditory area><Award><Behavioral><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain region><Cell Communication and Signaling><Cell Signaling><Clinical Treatment><Cognition><Communication><Complex><Comprehension><Cornu Ammonis><Data><Degenerative Disorder><Early identification><Encephalon><Encephalon Diseases><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Feedback><Functional MRI><Functional Magnetic Resonance Imaging><Goals><Hearing><Hearing Loss><Hippocampus><Human><Hypoacuses><Hypoacusis><Impairment><Individual><Intracellular Communication and Signaling><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Investigation><Knowledge><Link><Measures><Mediating><Memory><Methodology><Modeling><Modern Man><NIDCD><National Institute on Deafness and Other Communication Disorders><Participant><Pattern><Perception><Performance><Play><Presbyacusis><Presbycusis><Primary Senile Degenerative Dementia><Process><Public Health><Pure-Tone Audiometry><R21 Award><Research><Resolution><Risk><Role><Scanning><Signal Transduction><Signal Transduction Systems><Signaling><Speech><Stimulus><Stream><Structure><Task Performances><Testing><Visual><Visuospatial><age associated hearing loss><age associated pathologies><age dependent pathologies><age induced hearing loss><age induced pathologies><age related decline in hearing><age related hearing deficits><age related hearing impairment><age related hearing loss><aging associated hearing loss><aging associated pathologies><aging dependent pathologies><aging induced hearing loss><aging induced pathologies><aging pathologies><aging related decline in hearing><aging related hearing deficits><aging related hearing impairment><aging related hearing loss><aging related pathologies><alzheimer risk><auditory pathway><auditory processing><behavior measurement><behavioral measure><behavioral measurement><biological signal transduction><blood oxygen level dependent><blood oxygenation level dependent><career><clinical intervention><clinical investigation><clinical prognosis><clinical therapy><cognitive performance><degenerative condition><degenerative disease><dysfunctional hearing><fMRI><good hearing><healthy hearing><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><hearing in noise><high risk><hippocampal><human subject><mild cognitive decline><mild cognitive disorder><mild cognitive dysfunction><mild cognitive impairment><mild cognitive loss><mild neurocognitive impairment><millimeter><neural imaging><neuro-imaging><neuroimaging><neurological imaging><neuropathologic><neuropathological><neuropathology><normal hearing><novel><primary degenerative dementia><resolutions><risk factor for developing Alzheimer's><risk factor in Alzheimer's><risk of developing Alzheimer's><senile dementia of the Alzheimer type><social role><speech in background noise><speech in noise><speech in speech recognition><speech processing><speech recognition in noise><trial regimen><trial treatment><visual spatial>
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Gregory Corder

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 22/100
Recent
Active award
$203,125
FY 2026

Project Title

Deciphering Thalamocortical Circuit Dynamics Underlying Pain and Sleep Interactions

Grant Number:

1R21NS145093-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/29/2028

Project Abstract

ABSTRACT │ Chronic pain affects approximately 20% of the global population, significantly diminishing quality of life and posing a substantial socioeconomic burden. One of the most debilitating aspects of chronic pain is sleep disruption, which affects up to 90% of pain patients. Poor sleep worsens ...

Research Terms

<Acute Pain><Acutely painful><Affect><Affective><Anterior><Arousal><Attention><Automobile Driving><Behavior><Behavior Disorders><Behavioral><Biology><Biomedical Engineering><Brain><Brain Nervous System><Brain region><Calcium><Cardiac Chronotropism><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Clinical><Cognitive><Conscious><Consciousness><Data><Disease><Disorder><ECG><EEG><EKG><Economic Burden><Electrocardiogram><Electrocardiography><Electrodes><Electroencephalogram><Electroencephalography><Electromyography><Electrophysiology><Electrophysiology (science)><Encephalon><Exhibits><Foundations><Frequencies><Future><Generations><Genetic><Grant><Health><Heart Rate><Hour><Hypersensitivity><Image><Impairment><Implant><In vivo two-photon calcium imaging><Individual><Injury><Intracellular Communication and Signaling><Link><Maintenance><Maps><Mediating><Mental Health><Mental Hygiene><Mice><Mice Mammals><Modeling><Monitor><Motivation><Murine><Mus><NREM><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Nociception><Opsin><Outcome><Pain><Pain Control><Pain Therapy><Pain Threshold><Pain Tolerance Level><Pain management><Painful><Pathway interactions><Patients><Peripheral nerve injury><Play><Population><Population Dynamics><Process><Property><Psychological Health><QOL><Quality of life><Reporting><Research><Resolution><Rest><Risk><Rod-Opsin><Role><Signal Transduction><Signal Transduction Systems><Signaling><Sleep><Sleep Disorders><Sleep Fragmentations><Sleep disturbances><Stimulus><System><Techniques><Thalamic structure><Thalamus><Therapeutic Intervention><Time><Wakefulness><Work><aberrant sleep><acute to chronic pain transition><behavioral disorder><bio-engineered><bio-engineers><bioengineering><biological engineering><biological signal transduction><chronic pain><chronic pain condition><chronic pain disorder><chronic pain patient><chronic pain transition><chronic painful condition><cingulate cortex><co-morbid><co-morbidity><comorbidity><cost><data streams><deep learning><deep learning method><deep learning strategy><disrupted sleep><disturbed sleep><driving><electrophysiological><endomicrosope><experience><imaging><imaging in vivo><impaired sleep><improved><improvement on sleep><in vivo><in vivo calcium imaging><in vivo imaging><inhibit pain><injuries><intervention therapy><irregular sleep><learned behavior><learning behavior><microendoscope><nerve injury><neural><neural circuit><neural circuitry><neural injury><neural mechanism><neurocircuitry><neuromechanism><neuronal><neuropathic pain><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><nociceptive><non rapid eye movement><non-REM><non-rapid eye movement><nonREM><nonrapid eye movement><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><optogenetics><pain behavior><pain chronification><pain inhibition><pain intervention><pain patient><pain perception><pain processing><pain reduction><pain sensitivity><pain tolerance><pain treatment><painful neuropathy><pathway><patient with chronic pain><peripheral nerve crush injuries><poor sleep><prevent><preventing><quality of sleep><reduce pain><resolutions><restoration><sleep control><sleep diseases><sleep disruption><sleep dysfunction><sleep dysregulation><sleep illness><sleep improvement><sleep pattern><sleep problem><sleep quality><sleep regulation><sleep routine><sleep schedule><sleep/wake disruption><sleep/wake disturbance><sleep/wake patterns><sleep/wake regulation><social role><socio-economic><socio-economically><socioeconomically><socioeconomics><synaptic circuit><synaptic circuitry><thalamic><transition to chronic pain><voltage>
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Claude Desplan

NEW YORK UNIVERSITY, NEW YORK, NY

Exploratory lead · 22/100
Recent
Active award
$202,250
FY 2026

Project Title

A Comprehensive Cell-Type-Specific Developmental Genetic Toolkit for the Drosophila Visual System

Grant Number:

5R21NS140885-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Project Abstract

Project Summary (R21) Neural progenitors produce an enormous diversity of neuronal and glial cell types to form a functional nervous system. With the advance of single-cell genomic technologies, more and more cell types with distinct transcriptomic signatures have been defined; yet there is a signi...

Research Terms

<21+ years old><ATAC><ATAC sequencing><ATAC-seq><ATACseq><Adult><Adult Human><Antibodies><Area><Assay for Transposase-Accessible Chromatin using sequencing><Atlases><Basal Transcription Factor><Basal transcription factor genes><Behavior><Behavior Control><Behavioral Manipulation><Biologic Models><Biological Models><Body Tissues><Brain><Brain Nervous System><CRISPR><CRISPR/Cas system><Cell Body><Cells><Cellular Morphology><Chromatin><Clone Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Code><Coding System><Collection><Color><Communities><Corpora Bigemina><Data><Data Set><Development><Dissection><Drosophila><Drosophila genus><Encephalon><Enhancer Elements><Enhancers><Flies><Gene Combinations><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genetic Crosses><Genetic Enhancer Element><Genetic Markers><Genetic Transcription><Glia><Glial Cells><Goals><Individual><Intervening Sequences><Introns><Knock-in><Kolliker's reticulum><LPTN><Label><Model System><Modeling><Multiomic Data><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neural Stem Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic Body System><Neurologic Organ System><Neurons><Non-Polyadenylated RNA><Non-neuronal cell><Nonneuronal cell><Optic Lobe><Pattern><RNA><RNA Expression><RNA Gene Products><Research Resources><Resolution><Resources><Ribonucleic Acid><SCM-1><SCM-1a><SCM1><SCYC1><SCmRNAseq><Single cell mRNA seq><Single-Nucleus Sequencing><Specificity><Technology><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Visual System><XCL1><XCL1 gene><adulthood><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><behavioral control><biomarker identification><brain size><cell morphology><cell type><developmental><developmental genetics><enhancer sequence><fly><fruit fly><gene biomarker><gene expression biomarker><gene marker><gene signature biomarker><genetic approach><genetic biomarker><genetic enhancer sequence><genetic strategy><identification of biomarkers><identification of new biomarkers><interest><knockin><marker identification><multiomics><multiple omic data><multiple omics><nerve cement><nerve stem cell><neural><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenetics><neurogenic progenitors><neurogenic stem cell><neuron development><neuron progenitors><neuronal><neuronal circuit><neuronal circuitry><neuronal development><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><panomics><progenitor and neural stem cells><resolutions><sNuc-Seq><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell mRNA sequencing><single cell transcriptomic profiling><single nucleus RNA-sequencing><single nucleus seq><single-cell RNA sequencing><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><tool><transcription factor><transcriptomics>
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Mehmet Neset Ozel

NEW YORK UNIVERSITY, NEW YORK, NY

Exploratory lead · 22/100
Recent
Active award
$202,250
FY 2026

Project Title

A Comprehensive Cell-Type-Specific Developmental Genetic Toolkit for the Drosophila Visual System

Grant Number:

5R21NS140885-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Project Abstract

Project Summary (R21) Neural progenitors produce an enormous diversity of neuronal and glial cell types to form a functional nervous system. With the advance of single-cell genomic technologies, more and more cell types with distinct transcriptomic signatures have been defined; yet there is a signi...

Research Terms

<21+ years old><ATAC><ATAC sequencing><ATAC-seq><ATACseq><Adult><Adult Human><Antibodies><Area><Assay for Transposase-Accessible Chromatin using sequencing><Atlases><Basal Transcription Factor><Basal transcription factor genes><Behavior><Behavior Control><Behavioral Manipulation><Biologic Models><Biological Models><Body Tissues><Brain><Brain Nervous System><CRISPR><CRISPR/Cas system><Cell Body><Cells><Cellular Morphology><Chromatin><Clone Cells><Clustered Regularly Interspaced Short Palindromic Repeats><Code><Coding System><Collection><Color><Communities><Corpora Bigemina><Data><Data Set><Development><Dissection><Drosophila><Drosophila genus><Encephalon><Enhancer Elements><Enhancers><Flies><Gene Combinations><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generations><Genes><Genetic><Genetic Crosses><Genetic Enhancer Element><Genetic Markers><Genetic Transcription><Glia><Glial Cells><Goals><Individual><Intervening Sequences><Introns><Knock-in><Kolliker's reticulum><LPTN><Label><Model System><Modeling><Multiomic Data><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neural Stem Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic Body System><Neurologic Organ System><Neurons><Non-Polyadenylated RNA><Non-neuronal cell><Nonneuronal cell><Optic Lobe><Pattern><RNA><RNA Expression><RNA Gene Products><Research Resources><Resolution><Resources><Ribonucleic Acid><SCM-1><SCM-1a><SCM1><SCYC1><SCmRNAseq><Single cell mRNA seq><Single-Nucleus Sequencing><Specificity><Technology><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Visual System><XCL1><XCL1 gene><adulthood><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><behavioral control><biomarker identification><brain size><cell morphology><cell type><developmental><developmental genetics><enhancer sequence><fly><fruit fly><gene biomarker><gene expression biomarker><gene marker><gene signature biomarker><genetic approach><genetic biomarker><genetic enhancer sequence><genetic strategy><identification of biomarkers><identification of new biomarkers><interest><knockin><marker identification><multiomics><multiple omic data><multiple omics><nerve cement><nerve stem cell><neural><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenetics><neurogenic progenitors><neurogenic stem cell><neuron development><neuron progenitors><neuronal><neuronal circuit><neuronal circuitry><neuronal development><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><panomics><progenitor and neural stem cells><resolutions><sNuc-Seq><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell genomics><single cell mRNA sequencing><single cell transcriptomic profiling><single nucleus RNA-sequencing><single nucleus seq><single-cell RNA sequencing><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><tool><transcription factor><transcriptomics>
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Masmudur Mohammed Rahman

ARIZONA STATE UNIVERSITY-TEMPE CAMPUS, SCOTTSDALE, AZ

Exploratory lead · 22/100
Recent
Active award
$196,250
FY 2026

Project Title

Unravelling the mechanisms of virus host species jump

Grant Number:

5R21AI190589-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/16/2025

End Date:

12/31/2026

Project Abstract

Project Summary Uncovering the mechanisms enabling the cross-species jumps of viruses that happen in nature is essential for our understanding of viral spillovers, most notably those that can result in severe disease outbreaks, for example, the coronavirus SARS-CoV-2 pandemic and Mpox (monkeypox) ep...

Research Terms

<ATP-RNA Adenylyltransferase><Animals><Attenuated><Australia><Automobile Driving><Biologic Models><Biological><Biological Models><Body Tissues><Body part><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Cell Body><Cell Line><CellLine><Cells><Cellular Tropism><Climate><Collaborations><Cow Pox Virus><Cowpox virus><DNA Recombination><DNA cassette><DNA mutation><Death Rate><Deoxypyrimidine Kinase><Deoxythymidine Kinase><Disease><Disease Outbreaks><Disease Progression><Disorder><Domestic Rabbit><Dropsy><Edema><Epidemic><Europe><European><Event><Evolution><Farm><Future><Genes><Genetic Change><Genetic Recombination><Genetic defect><Genetic mutation><Genome><Genomics><Global Change><Hares><Horizontal Gene Transfer><Human><Hydrops><In Vitro><Infection><Kinetics><Knock-out><Knockout><Lagomorpha><Lagomorphs><Lateral Gene Transfer><Leporipoxvirus><Lepus><Lymphatic cell><Lymphocyte><Lymphocytic><Meteorological Climate><Model System><Modern Man><Monkey Pox><Monkey Pox Virus><Monkeypox><Monkeypox virus><Monkeypoxvirus><Mutation><Myxoma virus><Myxomatosis Virus><Names><Nature><ORFs><Open Reading Frames><Oryctolagus cuniculus><Outbreaks><PBMC><Pathogenicity><Peripheral Blood Mononuclear Cell><Poly A Polymerase><Polyadenylate Polymerase><Polyadenylate Synthetase><Polynucleotide Adenylyltransferase><Population><Poxviridae><Poxvirus Myxomatis><Poxviruses><Primary Lesion><Protein Coding Region><Proteins><Rabbits><Rabbits Mammals><Recombination><Reporting><Riboadenylate Transferase><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Site><Spain><Strains Cell Lines><Testing><Thymidine Kinase><Time><Tissues><Tropism><Variant><Variation><Viral><Viral Gene Products><Viral Gene Proteins><Viral Genes><Viral Proteins><Virion><Virus><Virus Particle><Weight Gain><Weight Increase><Zoonoses><Zoonotic><Zoonotic Infection><anthropogenesis><anthropogenic><attenuate><attenuates><biologic><body weight gain><body weight increase><cellular targeting><climatic><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><cross-species spillover><cross-species transmission><cultured cell line><cutaneous lesions><dermal lesion><driving><enhancer cassette><experiment><experimental research><experimental study><experiments><expression cassette><gene cassette><genetic cassette><genome mutation><host jump><host switching><in vivo><integration cassette><interspecies transmission><lymph cell><mortality rate><mpox><mpox virus><mpxv><mutant><name><named><naming><neutralizing antibody><novel><pox virus><programs><promoter cassette><reporter cassette><resistance cassette><selectable cassette><selection cassette><seroconversion><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><skin lesion><stop cassette><transcription cassette><transcriptional cassette><transgene cassette><transmission across species><transmission between species><transmitted across species><transmitted between species><transmitted cross-species><virus protein><wt gain>
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Liudi Tang

BARUCH S. BLUMBERG INSTITUTE, DOYLESTOWN, PA

Exploratory lead · 22/100
Recent
Active award
$195,750
FY 2026

Project Title

Identification of cellular functions involved in Hepatitis B Virus infection via a novel RNA sensing and editing dependent reporter system

Grant Number:

1R21AI196369-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/10/2026

End Date:

1/31/2028

Project Abstract

Abstract Hepatitis B virus (HBV) chronically infects 254 million people worldwide and accounts for 1.1 million deaths per year due to cirrhosis and liver cancer. Finding a cure for this disease is urgently needed, which requires a more thorough understanding of the key molecular events driving estab...

Research Terms

<Affect><Animals><Anti-viral Agents><Anti-viral Therapy><Applications Grants><Assay><Automobile Driving><Bioassay><Biologic Models><Biological Assay><Biological Models><Cell Body><Cell Culture Techniques><Cell Function><Cell Line><Cell Nucleus><Cell Physiology><Cell Process><Cell Survival><Cell Viability><CellLine><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cessation of life><Chemicals><Chimp><Chimpanzee><Chronic><Chronic Hepatitis B><Circular DNA><Cirrhosis><Complementary DNA><Core Particle><Data><Death><Delta Agent><Development><Disease><Disorder><Ducks><Endosomes><Enzyme Gene><Enzymes><Event><Genes><Genetic><Genetic Screening><Goals><Grant Proposals><HBV><HBV infection><Hep G2><HepG2><HepG2 cell line><Hepatic Cancer><Hepatic Cells><Hepatic Cirrhosis><Hepatic Parenchymal Cell><Hepatitis B Infection><Hepatitis B Virus><Hepatitis D Virus><Hepatitis Delta Virus><Hepatitis δ Virus><Hepatocarcinoma><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatocyte><Hepatoma><Host Factor><Host Factor Protein><Infection><Integration Host Factors><Investigation><Kinases><Knock-out><Knockout><Knowledge><Laboratories><Life Cycle><Life Cycle Stages><Liver Cells><Liver Cells Carcinoma><Liver Cirrhosis><Malignant neoplasm of liver><Mediating><Model System><Molecular><Na(+)-taurocholate-cotransporting peptide><Non-Polyadenylated RNA><Ntcp protein><Nuclear Envelope><Nuclear Membrane><Nucleosome Core><Nucleosome Core Particle><Nucleus><Pathway interactions><Persons><Phenotype><Phosphatases><Phosphohydrolases><Phosphomonoesterases><Phosphoric Monoester Hydrolases><Phosphotransferase Gene><Phosphotransferases><Primary carcinoma of the liver cells><Proteins><Puromicina><Puromycin><Puromycine><Puromycinum><RNA><RNA Editing><RNA Gene Products><RNA Sequences><RNA, Messenger, Editing><Receptor Protein><Receptosomes><Regimen><Reporter><Reporter Genes><Research><Resistance><Ribonucleic Acid><Risk><Stop Codon><Strains Cell Lines><Subcellular Process><System><TC cotransporting polypeptide><Termination Codon><Terminator Codon><Time><Translating><Translation Stop Signal><Transphosphorylases><Viral><Viral Genome><Virion><Virus><Virus Particle><Virus Replication><anti-viral compound><anti-viral drugs><anti-viral medication><anti-viral therapeutic><anti-virals><base editing><cDNA><cDNA Library><cell culture><cell cultures><chemical library><chronic HBV infection><chronic hepatitis B infection><chronic hepatitis B virus infection><chronic infections with hepatitis B virus><chronically infected with HBV><chronically infected with hepatitis B><cirrhotic><combat><cultured cell line><curative intervention><curative therapeutic><curative therapy><curative treatments><design><designing><developmental><driving><enhancing factor><gain of function><genome scale><genome wide screen><genome-wide><genomewide><hepatic NTCP><hepatitis B viral infection><hepatitis B virus infection><hepatoma cell><infected with HBV><infected with hepatitis B><infected with hepatitis B virus><infection with HBV><infection with hepatitis B virus><life course><liver cancer><liver carcinoma><liver malignancy><loss of function><macromolecule><malignant liver tumor><novel><overexpress><overexpression><particle><pathway><permissiveness><prototype><receptor><resistant><screening><screenings><sensor><small molecule libraries><sodium taurocholate cotransporting polypeptide><tissue/cell culture><viral RNA><viral infectious disease treatment><viral multiplication><viral replication><virus RNA><virus genome><virus host interaction><virus multiplication>
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Sonia Kupfer

UNIVERSITY OF CHICAGO, CHICAGO, IL

Exploratory lead · 22/100
Recent
Active award
$191,675
FY 2026

Project Title

Colonic bile acid metabolism and responses in African Americans and non-Hispanic Whites

Grant Number:

5R21CA280578-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/13/2024

End Date:

11/30/2026

Project Abstract

African Americans (AA) have among the highest colorectal cancer (CRC) incidence and mortality in the US. Environmental factors influenced by social factors, especially high fat diets, are known to increase CRC risk, but how these factors contribute to CRC risk differences is largely unknown. Bile ac...

Research Terms

<African><African American><African American group><African American individual><African American people><African American population><African Americans><Afro American><Afroamerican><Age><American><Apoptosis><Apoptosis Pathway><Area><Ascending colon><Attention><Bacteria><Bile Acids><Biological Markers><Biopsy><Blood Serum><Body Tissues><Cancers><Cellular Assay><Chicago><Clinical><Colon><Colon Cancer><Colon Carcinoma><Colorectal Cancer><Data><Deoxycholic Acid><Desoxycholic Acid><Diagnostic><Diet><Dietary Fats><Dihydroxycholanoic Acid><Environment><Environmental Factor><Environmental Risk Factor><Epithelium><Ethnic Origin><Ethnicity><European><Fats><Fatty acid glycerol esters><Feces><Functional Metagenomics><Future><GI microbiome><Gene Transcription><Genetic Transcription><Genotype><Goals><Hand><Hepatic><Hepatic Flexture><High Fat Diet><Host Factor><Host Factor Protein><Human><Incidence><Individual><Integration Host Factors><Intermediary Metabolism><Investigation><Isolithocholic Acid><Linear Regressions><Lithocholic Acid><Malignant Neoplasms><Malignant Tumor><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Metabolic Processes><Metabolism><Metagenomics><Microbiomics><Modern Man><Neighborhoods><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Organoids><Participant><Pathway interactions><Phenotype><Population><Population Control><Population Heterogeneity><Position><Positioning Attribute><Prevention><Prevention trial><Production><Programmed Cell Death><Proliferating><Prospective Studies><Prospective cohort><Prospective, cohort study><RNA Expression><Role><Sampling><Secondary to><Serum><Testing><Tissues><Transcription><Translating><Validation><Work><ages><bile acid metabolism><bile metabolism><bio-markers><biologic marker><biomarker><burden of disease><burden of illness><cancer in the colon><carcinogenicity><cell assay><colon cancer tumorigenesis><colon carcinogenesis><colon tumorigenesis><colorectal cancer risk><colorectal carcinogenesis><colorectal tumorigenesis><dehydroxylation><demographics><deprivation><dietary lipid><diets><digestive tract microbiome><disease burden><diverse populations><enteric microbiome><environmental risk><epigenomics><experience><fecal sample><gastrointestinal microbiome><gut microbiome><gut-associated microbiome><hands><heterogeneous population><individualized prevention><innovate><innovation><innovative><intestinal biome><intestinal microbiome><malignancy><microbial><microbiome><microbiome research><microbiome science><microbiome studies><mortality><multi-ethnic><multiethnic><neoplasm/cancer><pathway><personalized prevention><population diversity><precision prevention><primary outcome><prospective research study><prospective survey><response><secondary outcome><sex><social factors><social influence><social role><stool><stool sample><stool specimen><success><surveillance study><validations><western diet><western-style diet><western-type diet>
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Chuanlin Ding

UNIVERSITY OF LOUISVILLE, LOUISVILLE, KY

Exploratory lead · 22/100
Recent
Active award
$183,494
FY 2026

Project Title

Mitochondrial regulation of chemotherapy-induced reactive myelopoiesis and pro-metastatic effects

Grant Number:

5R21CA288604-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2025

End Date:

3/31/2027

Project Abstract

Recent studies and our preliminary data highlight the importance of myelopoiesis in the chemotherapy induced accumulation of immunosuppressive myeloid cells. Growing evidence also demonstrates the ability of hematopoietic stem and progenitor cells (HSPCs) to sense inflammation, ultimately regulating...

Research Terms

<14-Hydroxydaunomycin><Active Oxygen><Address><Adriamycine><Antioxidants><Anzatax><Approaches to prevention><Asotax><Blood Precursor Cell><Blood monocyte><Bone Marrow><Bone Marrow Reticuloendothelial System><Bristaxol><C-KIT Gene><CD117><CD117 Antigens><Cancer Treatment><Cell Body><Cells><Clinical><Combined Modality Therapy><Cytotoxic agent><Cytotoxic drug><Data><Dephosphin><Development><Difluorodeoxycytidine><Dose><Doxorubicin><Doxorubicina><Dynamin><Event><Exhibits><Exploratory/Developmental Grant><Glycolysis><Goals><Hematopoiesis><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic stem cells><Heterogeneity><Hydroxyl Daunorubicin><Hydroxyldaunorubicin><Immune response><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Inflammation><Intermediary Metabolism><Lung><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Macrophage><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Marrow monocyte><Mast Cell Growth Factor Receptor><Measures><Mediating><Mediator><Metabolic><Metabolic Processes><Metabolism><Metastasis><Metastasis Induction><Metastasis to the Lung><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Neoplasm to the Lung><Metastatic Tumor><Metastatic Tumor to the Lung><Mice><Mice Mammals><Mitochondria><Multimodal Therapy><Multimodal Treatment><Murine><Mus><Myeloid Cells><Myeloid-derived suppressor cells><Myelopoiesis><Mφ><Neoplasm Metastasis><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Oxygen Radicals><Paclitaxel><Paclitaxel (Taxol)><Phenotype><Phosphorylation><Praxel><Prevention approach><Primary Neoplasm><Primary Tumor><Pro-Oxidants><Production><Protein Phosphorylation><Proteins><Proto-Oncogene Protein c-kit><Public Health><R21 Mechanism><R21 Program><RNA Sequences><Reactive Oxygen Species><Regulation><Role><SCF Receptor><SCF Receptor Gene><SCFR><Secondary Neoplasm><Secondary Tumor><Source><Stem Cell Factor Receptor><Stem Cell Factor Receptor Gene><Structure><Structure of parenchyma of lung><Taxol><Taxol A><Taxol Konzentrat><Testing><Therapeutic><Time><Treatment Efficacy><Tumor Cell><anti-cancer therapy><blood cell formation><blood cell progenitor><blood progenitor><blood stem cell><blood-forming stem cell><c kit><c-kit Protein><c-kit Receptor><cancer metastasis><cancer microenvironment><cancer therapy><cancer-directed therapy><chemotherapy><combination cancer therapy><combination therapy><combined modality treatment><combined treatment><cytotoxic><dFdC><dFdCyd><developmental><exploratory developmental study><gemcitabine><hematopoietic progenitor><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><host response><immune suppression><immune suppressive activity><immune suppressive function><immune system response><immunoresponse><immunosuppressive activity><immunosuppressive function><immunosuppressive myeloid cells><immunosuppressive response><improved><inhibitor><insight><intervention efficacy><kit Proto-Oncogene Protein><knock-down><knockdown><lung metastasis><metabolism measurement><metabolomics><metabonomics><metastasize to the lung><mitochondrial><mitochondrial metabolism><monocyte><multi-modal cancer therapy><multi-modal neoplasm therapy><multi-modal therapy><multi-modal treatment><multimodality cancer therapy><multimodality neoplasm therapy><myeloid suppressor cells><myeloid-derived suppressive cells><neoplastic cell><new approaches><novel><novel approaches><novel strategies><novel strategy><p145(c-kit)><p145c-kit><progenitor cell differentiation><progenitor cell proliferation><progenitor differentiation><progenitor proliferation><pulmonary metastasis><response><response to therapy><response to treatment><social role><stem and progenitor cell proliferation><stem and progenitor differentiation><stem cell differentiation><stem cell proliferation><suppressive myeloid cells><therapeutic efficacy><therapeutic response><therapy efficacy><therapy response><treatment response><treatment responsiveness><tumor><tumor cell metastasis><tumor microenvironment>
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Katherine Acevedo

NORTHEASTERN UNIVERSITY, BOSTON, MA

Exploratory lead · 22/100
Recent
Active award
$159,490
FY 2026

Project Title

Design & Development of Brain Game Center Infrastructure

Grant Number:

1R50AG096861-01

Activity Code:

R50

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2029

Project Abstract

SUMMARY This project seeks to support Research Software Engineer (RSE) Katherine Acevedo’s efforts to develop open science tools to better measure and train cognition. Acevedo is currently the Director of Development at the Brain Game Center for Mental Fitness and Well-Being and in this role support...

Research Terms

<AD and related dementia><AD related dementia><ADRD><Address><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Apple><Architecture><Auditory><Basic Research><Basic Science><Behavioral><Biological Markers><Brain><Brain Nervous System><Clinical Research><Clinical Study><Cognition><Cognitive><Cognitive aging><Computer Software Development><Computer Software Engineering><Computer software><Decision Making><Dedications><Development><Early identification><Encephalon><Engineering><Engineering / Architecture><Funding><Hearing><Infrastructure><Intervention><Investigators><Language><Malus domestica><Measures><Mission><NIH><National Institutes of Health><Neuropsychologies><Neuropsychology><Personal Satisfaction><Play><Population Heterogeneity><Property><Psyche structure><Psychometrics><Public Health><Research><Research Personnel><Research Support><Researchers><Role><Secure><Sight><Software><Software Engineering><Structure><Students><System><Testing><Training><United States National Institutes of Health><Variant><Variation><Vision><Work><bio-markers><biologic marker><biomarker><cognitive assessment><cognitive control><cognitive reserve><cognitive testing><cognitive training><design><designing><developmental><diverse populations><early biomarkers><early detection biomarkers><early detection markers><executive control><executive function><fitness><flexibility><flexible><heterogeneous population><mental><neuropsychologic><novel><open data><open science><open-source data><population diversity><portability><rapid testing><research study><shareable platform><sharing platform><social role><tool><visual function><visual process><visual processing><well-being><wellbeing>
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Yulin Dai

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

Exploratory lead · 22/100
Recent
Active award
$41,246
FY 2026

Project Title

Administrative Supplement: Research Continuity Following Caregiving Responsibilities (R21AG087299)

Grant Number:

3R21AG087299-02S1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

4/30/2027

Project Abstract

The parent award, R21AG087299, develops interpretable deep learning frameworks to uncover genetic and transcriptomic programs that promote resilience to Alzheimer's disease (AD). The project integrates single-cell transcriptomics and genomics to identify actionable resilience pathways and potential ...

Research Terms

<AD dementia><Acceleration><Administrative Supplement><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Bioinformatics><Biological><Buffers><Cell Body><Cells><Cognitive><Computer Models><Computerized Models><Data><Data Set><Degenerative Neurologic Disorders><Dementia><Development><Drugs><Ensure><Evaluation><Event><Exploratory/Developmental Grant><Funding><Future><Gene Transcription><Genetic><Genetic Transcription><Genomics><Human Resources><Individual><Journals><Magazine><Manpower><Manuscripts><Medication><Methodology><Methods><Modeling><Multiomic Data><NIH><National Institutes of Health><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Outcome><Parents><Pathology><Pathway interactions><Pharmaceutical Preparations><Postdoc><Postdoctoral Fellow><Preparation><Preventative strategy><Preventative treatment><Prevention strategy><Preventive strategy><Preventive treatment><Primary Senile Degenerative Dementia><Printing><Process><Public Health><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><R21 Mechanism><R21 Program><RNA Expression><Research><Research Associate><Research Grants><Research Project Grants><Research Projects><Schedule><Scientific Publication><Therapeutic><Time><Transcription><United States National Institutes of Health><Validation><Work><biologic><build resilience><build resiliency><care giving><caregiving><combinatorial><computational framework><computational modeling><computational models><computational resources><computer based models><computer framework><computerized modeling><computing resources><cost><deep learning><deep learning based model><deep learning method><deep learning model><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><develop resilience><develop resiliency><developmental><drug/agent><enhance resilience><enhance resiliency><exploratory developmental study><facilitate resilience><improve resilience><improve resiliency><improved><increase resilience><increase resiliency><insight><multiple omic data><neurodegenerative illness><novel><parent><parent award><parent grant><parent project><pathway><personnel><post-doc><post-doctoral><post-doctoral trainee><preparations><prevent><preventing><primary degenerative dementia><programs><promote resilience><promote resiliency><protection pathway><protective pathway><research associates><resilience><resilience development><resilient><senile dementia of the Alzheimer type><single cell analysis><therapeutic target><timeline><transcriptomics><validations>
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Lishan Yu

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

Exploratory lead · 22/100
Recent
Active award
$41,246
FY 2026

Project Title

Administrative Supplement: Research Continuity Following Caregiving Responsibilities (R21AG087299)

Grant Number:

3R21AG087299-02S1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

4/30/2027

Project Abstract

The parent award, R21AG087299, develops interpretable deep learning frameworks to uncover genetic and transcriptomic programs that promote resilience to Alzheimer's disease (AD). The project integrates single-cell transcriptomics and genomics to identify actionable resilience pathways and potential ...

Research Terms

<AD dementia><Acceleration><Administrative Supplement><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Bioinformatics><Biological><Buffers><Cell Body><Cells><Cognitive><Computer Models><Computerized Models><Data><Data Set><Degenerative Neurologic Disorders><Dementia><Development><Drugs><Ensure><Evaluation><Event><Exploratory/Developmental Grant><Funding><Future><Gene Transcription><Genetic><Genetic Transcription><Genomics><Human Resources><Individual><Journals><Magazine><Manpower><Manuscripts><Medication><Methodology><Methods><Modeling><Multiomic Data><NIH><National Institutes of Health><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Outcome><Parents><Pathology><Pathway interactions><Pharmaceutical Preparations><Postdoc><Postdoctoral Fellow><Preparation><Preventative strategy><Preventative treatment><Prevention strategy><Preventive strategy><Preventive treatment><Primary Senile Degenerative Dementia><Printing><Process><Public Health><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><R21 Mechanism><R21 Program><RNA Expression><Research><Research Associate><Research Grants><Research Project Grants><Research Projects><Schedule><Scientific Publication><Therapeutic><Time><Transcription><United States National Institutes of Health><Validation><Work><biologic><build resilience><build resiliency><care giving><caregiving><combinatorial><computational framework><computational modeling><computational models><computational resources><computer based models><computer framework><computerized modeling><computing resources><cost><deep learning><deep learning based model><deep learning method><deep learning model><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><develop resilience><develop resiliency><developmental><drug/agent><enhance resilience><enhance resiliency><exploratory developmental study><facilitate resilience><improve resilience><improve resiliency><improved><increase resilience><increase resiliency><insight><multiple omic data><neurodegenerative illness><novel><parent><parent award><parent grant><parent project><pathway><personnel><post-doc><post-doctoral><post-doctoral trainee><preparations><prevent><preventing><primary degenerative dementia><programs><promote resilience><promote resiliency><protection pathway><protective pathway><research associates><resilience><resilience development><resilient><senile dementia of the Alzheimer type><single cell analysis><therapeutic target><timeline><transcriptomics><validations>
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Zhongming Zhao

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

Exploratory lead · 22/100
Recent
Active award
$41,246
FY 2026

Project Title

Administrative Supplement: Research Continuity Following Caregiving Responsibilities (R21AG087299)

Grant Number:

3R21AG087299-02S1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

4/30/2027

Project Abstract

The parent award, R21AG087299, develops interpretable deep learning frameworks to uncover genetic and transcriptomic programs that promote resilience to Alzheimer's disease (AD). The project integrates single-cell transcriptomics and genomics to identify actionable resilience pathways and potential ...

Research Terms

<AD dementia><Acceleration><Administrative Supplement><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Amentia><Bioinformatics><Biological><Buffers><Cell Body><Cells><Cognitive><Computer Models><Computerized Models><Data><Data Set><Degenerative Neurologic Disorders><Dementia><Development><Drugs><Ensure><Evaluation><Event><Exploratory/Developmental Grant><Funding><Future><Gene Transcription><Genetic><Genetic Transcription><Genomics><Human Resources><Individual><Journals><Magazine><Manpower><Manuscripts><Medication><Methodology><Methods><Modeling><Multiomic Data><NIH><National Institutes of Health><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Outcome><Parents><Pathology><Pathway interactions><Pharmaceutical Preparations><Postdoc><Postdoctoral Fellow><Preparation><Preventative strategy><Preventative treatment><Prevention strategy><Preventive strategy><Preventive treatment><Primary Senile Degenerative Dementia><Printing><Process><Public Health><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><R21 Mechanism><R21 Program><RNA Expression><Research><Research Associate><Research Grants><Research Project Grants><Research Projects><Schedule><Scientific Publication><Therapeutic><Time><Transcription><United States National Institutes of Health><Validation><Work><biologic><build resilience><build resiliency><care giving><caregiving><combinatorial><computational framework><computational modeling><computational models><computational resources><computer based models><computer framework><computerized modeling><computing resources><cost><deep learning><deep learning based model><deep learning method><deep learning model><deep learning strategy><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><develop resilience><develop resiliency><developmental><drug/agent><enhance resilience><enhance resiliency><exploratory developmental study><facilitate resilience><improve resilience><improve resiliency><improved><increase resilience><increase resiliency><insight><multiple omic data><neurodegenerative illness><novel><parent><parent award><parent grant><parent project><pathway><personnel><post-doc><post-doctoral><post-doctoral trainee><preparations><prevent><preventing><primary degenerative dementia><programs><promote resilience><promote resiliency><protection pathway><protective pathway><research associates><resilience><resilience development><resilient><senile dementia of the Alzheimer type><single cell analysis><therapeutic target><timeline><transcriptomics><validations>
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Kristen L. Janky

FATHER FLANAGAN'S BOYS' HOME, BOYS TOWN, NE

Exploratory lead · 22/100
Recent
Active award
$38,845
FY 2026

Project Title

Short-Term Research Training for AuD Students

Grant Number:

5T35DC008757-19

Activity Code:

T35

Mechanism:

Training, Institutional

Agency:

NIH

Start Date:

4/1/2007

End Date:

3/31/2028

Project Abstract

The objective of the Short-Term Research Training Program for AuD Students at Boys Town National Research Hospital (BTNRH) is to provide a 3-month, full-time, hands-on translational research experience to five predoctoral AuD students per year. This program is motivated by a shortage of audiologists...

Research Terms

<American><Audiology><Auditory><Clinical><Cognition><Computer software><Data Collection><Doctor of Philosophy><EXTMR><Environment><Event><Extramural><Extramural Activities><Faculty><Grant><Hearing><Hospitals><Human Resources><Interdisciplinary Research><Interdisciplinary Study><Journals><Laboratories><Language><Magazine><Manpower><Measurement><Measures><Mentors><Multidisciplinary Collaboration><Multidisciplinary Research><Ph D student><Ph D. student><Ph. D. student><Ph.D student><Ph.D.><Ph.D. student><PhD><PhD student><PhD. student><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Preparation><Process><Publications><Questionnaires><R-Series Research Projects><R01 Mechanism><R01 Program><Reporting><Research><Research Associate><Research Grants><Research Project Grants><Research Projects><Research Resources><Research Training><Resources><Science><Scientific Publication><Societies><Software><Speech><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Students><Technology><Traineeship><Training><Training Programs><Translational Research><Translational Science><Universities><Vestibular><Work><boys><career><community engagement><design><designing><doctoral student><engagement with communities><experience><faculty mentor><hospital laboratories><human subject><meeting><meetings><member><personnel><post-doc><post-doctoral><post-doctoral trainee><pre-doc><pre-doctoral><preparations><programs><recruit><research associates><research faculty><statistical analysis><success><translation research><translational investigation><vestibular system>
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Shigeki Miyamoto

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 20/100
Solid budget
Active award
$437,375
FY 2025

Project Title

NEK7 suppresses inflammation in the aging heart through regulation of RNA binding proteins

Grant Number:

1R21AG095645-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2027

Project Abstract

SUMMARY/ABSTRACT Aging is a major contributing factor to the development of heart failure (HF). Inflammation is now considered to be an important driver of the adverse cardiac remodeling and chronic low-grade inflammation is a hallmark of aging (inflammaging). NIMA-related kinase-7 (NEK7) is a serin...

Research Terms

<21+ years old><Adult><Adult Human><Affinity><Age><Aging><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Antigenic Determinants><Antigens><Antiinflammatory Effect><Antimorphic mutation><Apoptosis-Related Cysteine Protease Caspase 1><Applications Grants><Assay><Beta Proprotein Interleukin 1><Binding Determinants><Bioassay><Biological Assay><CASP-1><CASP1><CASP1 gene><CCL3><CCL3 gene><Cardiac><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular Diseases><Caspase-1><Caspase-1 Gene><Cause of Death><Cell Body><Cell Cycle Progression><Cell Death><Cells><Chemokine (C-C motif) Ligand 3><Chemotactic Cytokines><Chronic><Common Rat Strains><Data><Data Set><Development><Disease><Disorder><Dominant Negative><Dominant-Negative Mutant><Dominant-Negative Mutation><Dysfunction><ELISA><Echocardiogram><Echocardiography><Elderly><Enzyme-Linked Immunosorbent Assay><Epitopes><Exploratory/Developmental Grant><Fibrosis><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Functional disorder><Future><G0-G1 switch regulatory protein 24><G0S19-1><GOS24 protein><Gene Expression><Goals><Grant Proposals><Heart><Heart Muscle Cells><Heart failure><Heart myocyte><Homologous Chemotactic Cytokines><Human><Hypertrophy><ICE Protease><IL-1 beta><IL-1 beta Convertase><IL-1 beta-Converting Enzyme><IL-1 β><IL-1-b><IL-1BC><IL-1b Converting Enzyme><IL-1β><IL1-Beta><IL1-β><IL1B Protein><IL1B-Convertase><IL1BC><IL1BCE><IL1F2><IL1β><Immunoblotting><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><In Vitro><Inflammaging><Inflammasome><Inflammation><Inflammatory><Inflammatory Response><Intercrines><Interleukin 1-B Converting Enzyme><Interleukin 1-Beta Convertase><Interleukin 1beta><Interleukin-1 Beta Converting Enzyme><Interleukin-1 Converting Enzyme><Interleukin-1 beta><Interleukin-1β><Intervention><Kinases><L-Serine><LD78ALPHA><Link><MIP 1alpha><MIP-1-alpha><MIP-1a><MIP1A><Measurement><Mediating><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Muscle Cells><Myocarditis><Myocytes><NIMA><NIMA protein kinase><NIMA-related protein kinase><Nature><Neonatal><Non-Polyadenylated RNA><NuP475 protein><Organ><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Physiopathology><Play><Preinterleukin 1 Beta><Prevalence><Process><Protein Array><Protein Phosphorylation><Protein-Serine Kinase><Protein-Serine-Threonine Kinases><Protein-Threonine Kinase><Proteins><R21 Mechanism><R21 Program><RNA><RNA Gene Products><RNA metabolism><RNA-Binding Proteins><Rat><Rats Mammals><Rattus><Regulation><Regulatory Pathway><Reporting><Ribonucleic Acid><Role><SCYA3><SIS cytokines><Serine><Serine Kinase><Serine-Threonine Kinases><Serine/Threonine Protein Kinase Gene><Serotyping><Short interfering RNA><Signaling Factor Proto-Oncogene><Signaling Pathway Gene><Signaling Protein><Small Inducible Cytokine A3><Small Interfering RNA><Stem Cell Inhibitor><Stress><Structure><TIS11 protein><TTP protein><Threonine Kinase><Time><Transphosphorylases><Transthoracic Echocardiography><Ventricular><Western Blotting><Western Immunoblotting><Work><ZFP36 protein><adulthood><advanced age><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><age-related inflammation><aged mice><aged mouse><ages><aging associated><aging associated inflammation><aging prevention><aging related><anti aging><anti geronic><anti-inflammatory effect><antiaging><cardiac aging><cardiac dimension><cardiac failure><cardiac inflammation><cardiac size><cardiomyocyte><cardiovascular disorder><chemoattractant cytokine><chemokine><cytokine><developmental><elderly mice><enzyme linked immunoassay><experiment><experimental research><experimental study><experiments><exploratory developmental study><flow cytophotometry><geriatric><hallmarks of aging><heart aging><heart dimension><heart dimension/size><heart size><heart sonography><immunogen><inflamm-ageing><inflamm-aging><inflammation associated with aging><knock-down><knockdown><mRNA Degradation><mRNA Stability><mRNA Transcript Degradation><necrocytosis><old mice><overexpress><overexpression><pathophysiology><phospho-proteomics><phosphoproteomics><pillars of aging><prevent><prevent age related><prevent aging><preventing><promoter><promotor><protein blotting><response><senior citizen><siRNA><social role><suppress aging><tristetraprolin><vector>
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William Ellerbe Pelham III

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 20/100
Solid budget
Active award
$437,250
FY 2025

Project Title

Parental digital location tracking and adolescent substance misuse

Grant Number:

1R21DA061405-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2025

End Date:

6/30/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT In the past 5 years, at least 50% of parents in the U.S. have begun using GPS-based location of their teen’s smartphone (“digital location tracking”) to track where their teen is. Apps like Find My (Apple), Family Link (Google/Android), or Life360 give parents real-time, on-...

Research Terms

<12-20 years old><12th grade><Active Follow-up><Acute><Adolescence><Adolescent><Adolescent Youth><Alcohol Chemical Class><Alcohol Drinking><Alcohol consumption><Alcohols><Android><Behavior><Cannabis><Cell Phone><Cellular Phone><Cellular Telephone><Child Rearing><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><Data><Disclosure><Disease Frequency Surveys><Drug usage><Drugs><EtOH drinking><EtOH use><Evaluation><Exploratory/Developmental Grant><Family><Frequencies><Friends><High School Student><History><Home><Information Disclosure><Investigation><Knowledge><Learning><Life><Link><Location><Longitudinal Studies><Longitudinal Surveys><Measures><Medication><Mobile Phones><Monitor><Nature><Nicotine><On-Line Systems><Online Systems><Outcome><Parenting><Parenting behavior><Parents><Pharmaceutical Preparations><Policy Maker><Privatization><Publishing><R21 Mechanism><R21 Program><Reaction><Recording of previous events><Risk Reduction><Role><Schools><Scientist><Secondary School Student><Secondary Student><Survey Instrument><Surveys><Techniques><Technology><Teen><Teenagers><Testing><Time><Training><active followup><adolescence (12-20)><adolescent substance use><alcohol ingestion><alcohol intake><alcohol misuse><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><childrearing><cost><digital><drinking><drug misuse><drug use><drug/agent><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol misuse><ethanol product use><ethanol use><exploratory developmental study><follow up><follow-up><followed up><followup><high risk><high school senior><high schoolers><histories><homes><iPhone><improved><juvenile><juvenile human><long-term study><longitudinal outcome studies><medication misuse><online computer><parent><parent monitoring><parental monitoring><peer><recruit><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><response><risk-reducing><smart phone><smartphone><social role><substance misuse><substance use><substance use among adolescents><substance use among youth><substance using><teen years><teenage><theories><twelfth grade><unhealthy alcohol use><web based><youth substance use>
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Swaminathan Smita Iyer

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 20/100
Solid budget
Active award
$437,250
FY 2025

Project Title

CD4 Th1 and TCM as Modulators of Neuroinflammation

Grant Number:

1R21AG094321-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2025

End Date:

7/31/2027

Project Abstract

Project Summary Anti-retroviral therapy (ART) has transformed the management of HIV, turning a once-fatal illness into a chronic condition. However, the success of ART has also led to the emergence of chronic inflammatory diseases, particularly neurodegenerative disorders, as a significant challenge...

Research Terms

<AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Acute><Address><Age><Ammon Horn><Animals><Anti-HIV Positivity><Area><Attenuated><Automobile Driving><Autoregulation><B220><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><Brain><Brain Nervous System><Brain region><C-C CKR-5><C-C CKR-5 Gene><C-C Chemokine Receptor Type 5><C-C Chemokine Receptor Type 5 Gene><CC Chemokine Receptor 5><CC-CKR-5><CC-CKR-5 Gene><CC-CKR5><CCCKR5><CCCKR5 Gene><CCR-5><CCR-5 Gene><CCR5><CCR5 Protein><CCR5 Receptors><CCR5 gene><CD183><CD195 Antigen><CD195 Antigen Gene><CD3><CD3 Antigens><CD3 Complex><CD3 molecule><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD45><CHEMR13><CHEMR13 Gene><CKR-5><CKR-5 Gene><CKR-L2><CKR5><CKR5 Gene><CKR5 Receptors><CMKAR3><CMKBR5><CMKBR5 Gene><CNS Nervous System><CXCR3><CXCR3 gene><Cell Body><Cells><Central Nervous System><Cerebrospinal Fluid><Chemokine (C-C Motif) Receptor 5><Chemokine (C-C) Receptor 5><Chemokine (C-C) Receptor 5 Gene><Chemokine (C-X-C Motif) Receptor 3><Choroid Plexus><Chronic><Clinical><Clinical Treatment Moab><Cognitive><Cornu Ammonis><Data><Deep Cervical Lymph Node><Degenerative Neurologic Disorders><Development><Drugs><Encephalon><Euthanasia><Exhibits><Exploratory/Developmental Grant><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><G Protein-Coupled Receptor 9><GP180><GPR9><Genes><HIV><HIV 1 associated neurocognitive disorder><HIV Infections><HIV Positive><HIV Positivity><HIV Seroconversion><HIV Seropositivity><HIV antibody positive><HIV associated neurocognitive deficit><HIV associated neurocognitive impairment><HIV induced neurocognitive deficit><HIV induced neurocognitive impairment><HIV neurocognitive impairment><HIV-1 Fusion Co-Receptor><HIV-1 Fusion Co-Receptor Gene><HIV-1 associated neurocognitive deficit><HIV-1 associated neurocognitive disorder><HIV-1 associated neurocognitive impairment><HIV-associated neurocognitive disorder><HTLV-III Infections><HTLV-III Seroconversion><HTLV-III Seropositivity><HTLV-III-LAV Infections><Hippocampus><Homeostasis><Hortega cell><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><IFN><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><IP10><IP10 Receptor><IP10-Mig receptor><IP10-R><Immune><Immune Cell Activation><Immune Interferon><Immune infiltrates><Immunes><Immunocompetent><Immunomodulation><Impairment><Individual><Infection><Inflammation><Inflammatory><Interferon Gamma><Interferon Type II><Interferons><Intervention><Knowledge><LAV-HTLV-III><LY5><Laboratories><Ligands><Lymphadenopathy-Associated Virus><Lymphatic Tissue><Lymphoid Tissue><M mulatta><M. mulatta><MMAC1><MMAC1 protein><MS treatment><Macaca><Macaca mulatta><Macaca rhesus><Macaque><Medication><Memory><Mercy Killing><Mice><Mice Mammals><Microglia><Mig Receptor><Mig-R><MigR><Modeling><Monoclonal Antibodies><Morphology><Murine><Mus><Mutated in Multiple Advanced Cancers 1><Nerve Degeneration><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neurocognitive Impairment in HIV><Neurocognitive Impairment in HIV-1><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><OKT3 antigen><Outcome><PHTS gene><PHTS protein><PTEN><PTEN gene><PTEN protein><PTEN1><PTPRC><PTPRC gene><Pathogenesis><Peripheral><Persons><Pharmaceutical Preparations><Phase><Phosphatase and Tensin Homolog><Phosphatase and Tensin Homolog Deleted on Chromosome 10><Physiological Homeostasis><Prefrontal Cortex><Process><Proteins><Publishing><R21 Mechanism><R21 Program><Residual><Residual state><Rhesus><Rhesus Macaque><Rhesus Monkey><Role><SIV><Sampling><Simian Immunodeficiency Viruses><Site><Skull><Structure of choroid plexus><Symptoms><Synapses><Synaptic><T cell infiltration><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T200><T3 Antigens><T3 Complex><T3 molecule><T4 Cells><T4 Lymphocytes><Testing><Therapeutic><Tissues><Viral><Viral Burden><Viral Load><Viral Load result><Virus><Virus-HIV><acute infection><ages><antiretroviral therapy><antiretroviral treatment><attenuate><attenuates><blood cerebrospinal fluid barrier><brain parenchyma><cerebral spinal fluid><challenge in rhesus macaques><chronic inflammatory disease><cranium><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><design><designing><developmental><driving><drug/agent><experience><exploratory developmental study><flow cytophotometry><gitter cell><glial activation><glial cell activation><high dimensionality><high risk><hippocampal><immune activation><immune cell infiltrate><immune competent><immune modulation><immune regulation><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><infected rhesus macaques><infected rhesus monkey><infection in rhesus macaques><infection of rhesus macaques><innovate><innovation><innovative><insight><interest><lFN-Gamma><mAbs><mesoglia><microglial cell><microgliocyte><monoclonal Abs><multiple sclerosis therapy><multiple sclerosis treatment><multiplexed imaging><mutated in multiple advanced cancers 1 protein><nerve cell death><nerve cell loss><neural degeneration><neural inflammation><neurodegeneration><neurodegenerative><neurodegenerative illness><neuroinflammation><neuroinflammatory><neurological degeneration><neuron cell death><neuron cell loss><neuron death><neuron loss><neuronal cell death><neuronal cell loss><neuronal death><neuronal degeneration><neuronal loss><non-human primate><nonhuman primate><novel><pathogen><perivascular glial cell><phosphatase and tensin homologue on chromosome ten><programs><recruit><response><rhesus challenge><rhesus macaque challenge><rhesus monkey infection><social role><spinal fluid><success><synapse><thymus derived lymphocyte>
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Bruce H Appel

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 20/100
Solid budget
Active award
$429,000
FY 2025

Project Title

A synaptogenic adhesion code for myelin specificity

Grant Number:

1R21MH140123-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

5/31/2027

Project Abstract

PROJECT SUMMARY Human brain function requires that neuronal axons are ensheathed by myelin, a specialized, lipid-rich membrane produced by oligodendrocytes, one of the principal glial cell types of the central nervous system. Myelin, the white matter of the brain, insulates axons, improving electric...

Research Terms

<ASD><Adhesion Molecule><Adhesions><Adhesives><Animals><Autism><Autistic Disorder><Axon><Behavior><Biologic Models><Biological Models><Brachydanio rerio><Brain><Brain Nervous System><CD56><CNS Nervous System><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Candidate Disease Gene><Candidate Gene><Cas nuclease technology><Cell Adhesion><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Lineage><Cell membrane><Cellular Adhesion><Central Nervous System><Chromosomal Insertion><Chromosome Mapping><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Code><Coding System><Confocal Microscopy><Curiosities><Cytoplasmic Membrane><DNA seq><DNA sequencing><DNAseq><Danio rerio><Data><Development><Diagnosis><Disease><Disorder><Dysfunction><Early Infantile Autism><Encephalon><Exploratory/Developmental Grant><Functional disorder><Future><Gene Alteration><Gene Expression><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Mutation><Gene Proteins><Gene variant><Generalized Growth><Genes><Genetic><Genome><Glia><Glial Cells><Growth><Health><Human><Impairment><Individual><Infantile Autism><Investigation><Kanner's Syndrome><Knowledge><Kolliker's reticulum><Learning><Link><Linkage Mapping><Lipids><Maintenance><Maps><Mediating><Membrane><Memory><Mice><Mice Mammals><Model System><Modern Man><Modification><Molecular><Murine><Mus><Myelin><Myelin Sheath><NCAM><NCAM1><NCAM1 gene><Nerve Cells><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Non-neuronal cell><Nonneuronal cell><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Persons><Physiopathology><Plasma Membrane><Postsynaptic Membrane><Protein Gene Products><Proteins><Publishing><R21 Mechanism><R21 Program><Reporter><Reporter Genes><Research><Specific qualifier value><Specificity><Specified><Synapses><Synaptic><Synaptic Membranes><System><Testing><Tissue Growth><Total Human and Non-Human Gene Mapping><Transgenes><Transgenic Organisms><Transmission><Variant><Variation><Visualization software><Work><Zebra Danio><Zebra Fish><Zebrafish><allelic variant><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic-like symptoms><brain abnormalities><cell adhesion protein><cell type><developmental><differential expression><differentially expressed><excitatory neuron><experiment><experimental research><experimental study><experiments><exploratory developmental study><extracellular><gene defect><gene function><gene manipulation><genetic manipulation><genetic mapping><genetic variant><genetically manipulate><genetically perturb><genomic variant><imaging in vivo><improved><in vivo><in vivo imaging><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><inhibitory neuron><innovate><innovation><innovative><loss of function mutation><low-frequency mutation><membrane structure><mutant allele><myelination><nerve cement><neuronal><neuropsychiatric disease><neuropsychiatric disorder><novel><oligodendrocyte lineage><ontogeny><pathophysiology><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><plasmalemma><postsynaptic><presynaptic><protein expression><protein function><rare allele><rare mutation><rare variant><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><substantia alba><synapse><tool><transcriptional differences><transgene><transgenic><transmission process><visualization tool><white matter>
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MISUNG JO

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Exploratory lead · 20/100
Solid budget
Active award
$419,014
FY 2025

Project Title

SOX9: A Novel Mediator of the Ovulatory Process in the Human Ovary

Grant Number:

1R21HD119324-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2027

Project Abstract

Abstract Ovarian disorders in women, including defects in ovulation and subsequent corpus luteum (CL) development, account for up to 30% of all infertility cases. Understanding the mechanism underlying these processes is critically important, as this knowledge provides a foundation for our ability ...

Research Terms

<7-Ethoxyresorufin O-Deethylase><Automobile Driving><Basal Transcription Factor><Basal transcription factor genes><Belief><Body Tissues><CYP 1A1><CYP11A><CYP11A1><CYP11A1 gene><CYP1A1 Product><CYP1A1 Protein><Cannot achieve a pregnancy><Cell Body><Cell Culture Techniques><Cell Function><Cell Isolation><Cell Physiology><Cell Process><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Cellular Function><Cellular Physiology><Cellular Process><ChIP Sequencing><ChIP-seq><ChIPseq><Corpus Luteum Hormone><Cytochrome P-450 CYP1A1><Cytochrome P450 1A1><Cytochrome P450 IA1><Cytochrome P450, Subfamily I (Aromatic Compound-Inducible), Polypeptide 1><Data><Defect><Delta4-pregnene-3,20-dione><Development><Difficulty conceiving><Dioxin-Inducible Cytochrome P1-450><EROD><Endocrine Gland Secretion><Ethoxyresorufin Dealkylase><Ethoxyresorufin O-Deethylase><Ethylresorufin O-Deethylase><Event><Exploratory/Developmental Grant><Fecundability><Fecundity><Fertility><Foundations><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Transcription><Gonadal structure><Gonadotropins><Hormones><Hour><Human><Human Chorionic Gonadotropin><Infertility><Informatics><Knowledge><Lead><Life><Luteal Cells><Lutein Cells><Luteinization><Mediating><Mediator><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Morphology><Murine><Mus><Oocytes><Ovarian><Ovarian Diseases><Ovarian Disorder><Ovarian Tissue><Ovary><Ovocytes><Ovulation><P450 Form 6><P450-1A1><P450-P1><P450SCC><Pathway interactions><Pattern><Pb element><Phase><Phenotype><Pilot Projects><Play><Pregn-4-ene-3,20-dione><Pregnenedione><Process><Production><Progesterone><Progesterone Receptors><Progestin Receptors><R21 Mechanism><R21 Program><RNA Expression><Repression><Reproductive Health><Role><Rupture><Short interfering RNA><Small Interfering RNA><Subcellular Process><Testing><Therapeutic Hormone><Therapeutic Progesterone><Time><Tissue Sample><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transcriptional Control><Transcriptional Regulation><Upregulation><Woman><adenoviral mediated><adenovirus-mediated><analog><anovulatory disorder><cell culture><cell cultures><cell sorting><chromatin immunoprecipitation coupled with sequencing><chromatin immunoprecipitation followed by sequencing><chromatin immunoprecipitation with sequencing><chromatin immunoprecipitation-seq><chromatin immunoprecipitation-sequencing><corpus luteum><developmental><driving><exploratory developmental study><female fertility><fertility cessation><fertility loss><gonad><gonads><granulosa cell><hCG><heavy metal Pb><heavy metal lead><improved><in vivo><infertile><insight><knock-down><knockdown><novel><ovary disorder><pathway><pilot study><scRNA sequencing><scRNA-seq><sex><sex determination><shRNA><short hairpin RNA><siRNA><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><small hairpin RNA><social role><spatial and temporal><spatial temporal><spatiotemporal><stem><transcription factor><transcriptomics>
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Eva-Maria Schoetz Collins

SWARTHMORE COLLEGE, SWARTHMORE, PA

Exploratory lead · 20/100
Solid budget
Active award
$391,640
FY 2025

Project Title

Organophosphorus pesticide bioactivation and detoxification in an invertebrate rapid screening model to study mechanisms of neurotoxicity

Grant Number:

1R21ES037433-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

5/31/2027

Project Abstract

Objectives. Organophosphorus pesticides (OPs) have been implicated in the dramatic surge of neurodevelopmental problems among U.S. children. Acute OP poisoning is due to inhibition of acetylcholinesterase (AChE). Chronic exposure to environmentally relevant OP levels has been suggested to cause deve...

Research Terms

<0-11 years old><21+ years old><Acetylcholine Hydrolase><Acetylcholinesterase><Acute><Acylcholine acylhydrolase><Acylcholineacylhydrolase><Adult><Adult Human><Affect><Ali-esterase><Amino Acid Sequence><Aryl-dialkyl Phosphatase><Arylalkylphosphatase><Aryltriphosphatase><Aryltriphosphate dialkylphosphohydrolase><Assay><B-esterase><Behavior><Behavioral><Bioassay><Biochemical><Biological Assay><Butyrylcholinesterase><CAP-hydrolyzing Enzyme><Calcium><Capsaicin-Hydrolyzing Enzyme><Carboxyesterase><Carboxylate Esterase><Carboxylester Lipase><Carboxylesterase B><Carboxylesterases><Carboxylic Ester Hydrolase><Carboxylic Ester Hydrolases><Chemicals><Child><Child Youth><Children (0-21)><Cholinesterases><Chronic><Cytochrome P-450><Cytochrome P-450 Enzyme System><Cytochrome P450><Cytochrome P450 Family Gene><Cytochrome a><Cytochromes><DNA Molecular Biology><Data><Defect><Development><Drug Metabolic Detoxication><Drug Metabolic Detoxification><Dugesia><Dugesia (turbellarian)><Environment><Enzyme Gene><Enzymes><Esterase B1><Esterase E4><Exhibits><Exploratory/Developmental Grant><Exposure to><Foundations><Fresh Water><Freshwater><Future><GeneHomolog><Genes><Goals><Grant><High Throughput Assay><Homocysteine Thiolactone Hydrolase><Homolog><Homologous Gene><Homologue><Human><In Situ><In Situ Hybridization><In Vitro><Intermediary Metabolism><Invertebrata><Invertebrates><Isocarboxazid amidase><Kinetics><Knowledge><Link><Measures><Metabolic Activation><Metabolic Drug Detoxications><Metabolic Processes><Metabolism><Metabolism of Toxic Agents><Methods><Modeling><Modern Man><Molecular><Molecular Biology><Naproxen Esterase><Natural regeneration><Nerve Cells><Nerve Regeneration><Nerve Unit><Neural Cell><Neural Development><Neuro-regeneration><Neurocyte><Neurodevelopmental Problem><Neurologic><Neurological><Neurons><Neuroregeneration><Non-specific Carboxylesterase><Non-specific Esterase><Nonspecific Esterase><OPA Anhydrase><OPH Enzyme><Organophosphorus Acid Anhydrase><Organophosphorus Acid Anhydrolase><Organophosphorus Acid Hydrolase><Organophosphorus Hydrolase><P450><Paraoxon esterase><Paraoxonase><Pathway interactions><Pesticides><Phenotype><Phosphoric Triester Hydrolases><Phosphotriesterase><Physiologic><Physiological><Physiology><Pirimiphos-methyloxon esterase><Planarians><Play><Post-Transcriptional Gene Silencing><Primary Protein Structure><Procaine Esterase><Proteins><R21 Mechanism><R21 Program><RNA Interference><RNA Silencing><RNA interference screen><RNAi><RNAi screen><RNAi-based screen><Rapid screening><Regeneration><Research><Role><Sequence-Specific Posttranscriptional Gene Silencing><Testing><Toxic effect><Toxicities><Toxicology><Visualization><Xenobiotic Metabolism><acetylcholine acetylhydrolase><adulthood><aryldialkylphosphatase><asexual><behavior phenotype><behavioral phenotyping><carboxylesterase><choline esterase I><choline esterase II><cholinergic><college><collegiate><comparative><cost effective><detoxification><developmental><developmental neurotoxicity><exploratory developmental study><global gene expression><global transcription profile><high throughput screening><in situ Hybridization Genetics><in situ Hybridization Staining Method><inhibitor><insight><kids><knock-down><knockdown><nervous system development><nervous system regeneration><neural regeneration><neurodevelopment><neuron toxicity><neuronal><neuronal toxicity><neuroregenerative><neurotoxic><neurotoxicity><pathway><pesticide exposure><pesticide poisoning><pesticide toxicity><phosphorothioate><protein sequence><regenerate><regenerated nerve><screening><screenings><social role><tool><transcriptome><undergrad><undergraduate><undergraduate student><youngster>
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Louisa Sylvia

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 20/100
Solid budget
Active award
$323,624
FY 2025

Project Title

Healthy Activity Improves Lives (HAIL)

Grant Number:

5R33AG067091-05

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2021

End Date:

5/31/2026

Project Abstract

PROJECT SUMMARY HAIL ABSTRACT Older adults (age ≥ 60 years) tend to be less physically active than younger adults, engaging in less than 11% of recommended physical activity (PA) levels. Lack of PA in older adults is associated with increased risk of all-cause mortality. Large population-based studi...

Research Terms

<21+ years old><Accelerometer><Active Follow-up><Address><Adult><Adult Human><Advocacy><African American church><Age><Black><Black Populations><Black church><Black group><Black individual><Black people><Black race><Blacks><Boston><Bypass><Chronic Disease><Chronic Illness><Church><Communities><Decrease health disparities><Development><Education><Educational aspects><Endowment><Exercise><Exploratory/Developmental Grant><Feasibility Studies><Feedback><Focus Groups><Funding><Health><Health Benefit><Health disparity mitigation><Health disparity reduction><Intervention><Interview><Lower health disparities><Measures><Mitigate health disparities><Modeling><National Institute of Aging><National Institute on Aging><Older Population><Outcome><Participant><Persons><Phase><Physical activity><Pilot Projects><Policies><Population><Population Study><Program Accessibility><Public Health><R21 Mechanism><R21 Program><Randomized><Recommendation><Reduce health disparities><Research><Research Support><Risk><Schedule><Site><Structure><Training><accelerometry><acceptability and feasibility><active followup><activity monitor><activity tracker><adult youth><adulthood><ages><chronic disorder><cost><developmental><ethnic diversity><ethnically diverse><evidence base><exercise intervention><experience><exploratory developmental study><fitbit><follow up><follow-up><followed up><followup><improved><instructor><lack of physical activity><moderate-to-vigorous physical activity><mortality><older adult><older adulthood><older groups><older individuals><older person><peer><physical activity intervention><physical inactivity><pilot study><pilot trial><population-based study><population-level study><programs><randomisation><randomization><randomly assigned><satisfaction><studies of populations><study of the population><trend><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><young adult><young adult age><young adulthood>
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Ana-Maria Vranceanu

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 20/100
Solid budget
Active award
$323,624
FY 2025

Project Title

Healthy Activity Improves Lives (HAIL)

Grant Number:

5R33AG067091-05

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2021

End Date:

5/31/2026

Project Abstract

PROJECT SUMMARY HAIL ABSTRACT Older adults (age ≥ 60 years) tend to be less physically active than younger adults, engaging in less than 11% of recommended physical activity (PA) levels. Lack of PA in older adults is associated with increased risk of all-cause mortality. Large population-based studi...

Research Terms

<21+ years old><Accelerometer><Active Follow-up><Address><Adult><Adult Human><Advocacy><African American church><Age><Black><Black Populations><Black church><Black group><Black individual><Black people><Black race><Blacks><Boston><Bypass><Chronic Disease><Chronic Illness><Church><Communities><Decrease health disparities><Development><Education><Educational aspects><Endowment><Exercise><Exploratory/Developmental Grant><Feasibility Studies><Feedback><Focus Groups><Funding><Health><Health Benefit><Health disparity mitigation><Health disparity reduction><Intervention><Interview><Lower health disparities><Measures><Mitigate health disparities><Modeling><National Institute of Aging><National Institute on Aging><Older Population><Outcome><Participant><Persons><Phase><Physical activity><Pilot Projects><Policies><Population><Population Study><Program Accessibility><Public Health><R21 Mechanism><R21 Program><Randomized><Recommendation><Reduce health disparities><Research><Research Support><Risk><Schedule><Site><Structure><Training><accelerometry><acceptability and feasibility><active followup><activity monitor><activity tracker><adult youth><adulthood><ages><chronic disorder><cost><developmental><ethnic diversity><ethnically diverse><evidence base><exercise intervention><experience><exploratory developmental study><fitbit><follow up><follow-up><followed up><followup><improved><instructor><lack of physical activity><moderate-to-vigorous physical activity><mortality><older adult><older adulthood><older groups><older individuals><older person><peer><physical activity intervention><physical inactivity><pilot study><pilot trial><population-based study><population-level study><programs><randomisation><randomization><randomly assigned><satisfaction><studies of populations><study of the population><trend><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><young adult><young adult age><young adulthood>
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NATHAN I SHAPIRO

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 20/100
Solid budget
Active award
$256,785
FY 2025

Project Title

Genetically Linked Metabolites of Sepsis Severity and Mortality

Grant Number:

1R21HL181071-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2025

End Date:

8/31/2027

Project Abstract

Sepsis and its consequences such as organ dysfunction and failure remain significant human health problems. We have identified blood metabolites (small molecular weight compounds) including a by-product of mitochondrial fatty acid β-oxidation, acetylcarnitine (C2), that are associated with sepsis-in...

Research Terms

<Acetyl Carnitine><Acetylcarnitine><Age><American><Attenuated><BMI><BMI percentile><BMI z-score><Biological><Blood><Blood Plasma><Blood Reticuloendothelial System><Body mass index><Cell Body><Cells><Chronic><Clinical><Clinical Trials><Critical Illness><Critically Ill><DNA><Data><Data Set><Deoxyribonucleic Acid><Diabetes Mellitus><Disease><Disorder><Drug Targeting><Drug Therapy><Dysfunction><Exploratory/Developmental Grant><Failure><Fatty Acids><Functional disorder><Future><GWA study><GWAS><Gene variant><Genes><Genetic><Genomics><Health><Heterogeneity><Human><Hypotension><Inflammatory><Intermediary Metabolism><Knowledge><L Carnitine><Levocarnitine><Link><Liquid substance><Low Blood Pressure><Measures><Metabolic><Metabolic Processes><Metabolism><Mitochondria><Modern Man><Molecular><Molecular Weight><NHLBI><National Heart, Lung, and Blood Institute><Organ><Outcome><Participant><Patients><Pharmacological Treatment><Pharmacotherapy><Physiologic><Physiological><Physiopathology><Placebos><Plasma><Plasma Serum><Process><Quetelet index><R21 Mechanism><R21 Program><Regulation><Regulator Genes><Research Specimen><Resuscitation><Reticuloendothelial System, Serum, Plasma><Sepsis><Severities><Sham Treatment><Single Base Polymorphism><Single Nucleotide Polymorphism><Specimen><Survivors><Testing><Transcriptional Regulatory Elements><Vascular Hypotensive Disorder><Vasoactive Agonists><Vasoconstrictor Agents><Vasoconstrictor Drugs><Vasoconstrictors><Vasopressor Agents><Vitamin B T><Work><acylcarnitine><ages><allelic variant><antisepsis treatment><attenuate><attenuates><attenuation><biologic><clinical trial enrollment><co-morbid><co-morbidity><cohort><comorbidity><crystalloid><cytokine><diabetes><drug intervention><drug treatment><entire genome><exploratory developmental study><fluid><full genome><genetic association><genetic trans acting element><genetic variant><genome sequencing><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic data><genomic dataset><genomic variant><high risk><individuals with sepsis><insight><intervention arm><liquid><metabolism measurement><metabolomics><metabonomics><mitochondrial><mortality><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><oxidation><pathophysiology><patients with sepsis><people with sepsis><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><primary end point><primary endpoint><randomized, clinical trials><regulatory gene><secondary analysis><sepsis care><sepsis groups><sepsis interventions><sepsis management><sepsis patients><sepsis population><sepsis subjects><sepsis survivor><sepsis survivorship><sepsis therapeutics><sepsis therapy><sepsis treatment><septic group><septic individuals><septic patients><septic people><septic population><septic subject><septic survival><septic survivor><septic therapy><septic treatment><severe sepsis><severely septic><sex><sham therapy><single nucleotide variant><small molecule><subjects with sepsis><survive sepsis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><trans acting element><treat sepsis><treatment arm><vasopressor><whole genome><whole genome association analysis><whole genome association study>
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KATHLEEN A STRINGER

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 20/100
Solid budget
Active award
$256,785
FY 2025

Project Title

Genetically Linked Metabolites of Sepsis Severity and Mortality

Grant Number:

1R21HL181071-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2025

End Date:

8/31/2027

Project Abstract

Sepsis and its consequences such as organ dysfunction and failure remain significant human health problems. We have identified blood metabolites (small molecular weight compounds) including a by-product of mitochondrial fatty acid β-oxidation, acetylcarnitine (C2), that are associated with sepsis-in...

Research Terms

<Acetyl Carnitine><Acetylcarnitine><Age><American><Attenuated><BMI><BMI percentile><BMI z-score><Biological><Blood><Blood Plasma><Blood Reticuloendothelial System><Body mass index><Cell Body><Cells><Chronic><Clinical><Clinical Trials><Critical Illness><Critically Ill><DNA><Data><Data Set><Deoxyribonucleic Acid><Diabetes Mellitus><Disease><Disorder><Drug Targeting><Drug Therapy><Dysfunction><Exploratory/Developmental Grant><Failure><Fatty Acids><Functional disorder><Future><GWA study><GWAS><Gene variant><Genes><Genetic><Genomics><Health><Heterogeneity><Human><Hypotension><Inflammatory><Intermediary Metabolism><Knowledge><L Carnitine><Levocarnitine><Link><Liquid substance><Low Blood Pressure><Measures><Metabolic><Metabolic Processes><Metabolism><Mitochondria><Modern Man><Molecular><Molecular Weight><NHLBI><National Heart, Lung, and Blood Institute><Organ><Outcome><Participant><Patients><Pharmacological Treatment><Pharmacotherapy><Physiologic><Physiological><Physiopathology><Placebos><Plasma><Plasma Serum><Process><Quetelet index><R21 Mechanism><R21 Program><Regulation><Regulator Genes><Research Specimen><Resuscitation><Reticuloendothelial System, Serum, Plasma><Sepsis><Severities><Sham Treatment><Single Base Polymorphism><Single Nucleotide Polymorphism><Specimen><Survivors><Testing><Transcriptional Regulatory Elements><Vascular Hypotensive Disorder><Vasoactive Agonists><Vasoconstrictor Agents><Vasoconstrictor Drugs><Vasoconstrictors><Vasopressor Agents><Vitamin B T><Work><acylcarnitine><ages><allelic variant><antisepsis treatment><attenuate><attenuates><attenuation><biologic><clinical trial enrollment><co-morbid><co-morbidity><cohort><comorbidity><crystalloid><cytokine><diabetes><drug intervention><drug treatment><entire genome><exploratory developmental study><fluid><full genome><genetic association><genetic trans acting element><genetic variant><genome sequencing><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic data><genomic dataset><genomic variant><high risk><individuals with sepsis><insight><intervention arm><liquid><metabolism measurement><metabolomics><metabonomics><mitochondrial><mortality><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><oxidation><pathophysiology><patients with sepsis><people with sepsis><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><primary end point><primary endpoint><randomized, clinical trials><regulatory gene><secondary analysis><sepsis care><sepsis groups><sepsis interventions><sepsis management><sepsis patients><sepsis population><sepsis subjects><sepsis survivor><sepsis survivorship><sepsis therapeutics><sepsis therapy><sepsis treatment><septic group><septic individuals><septic patients><septic people><septic population><septic subject><septic survival><septic survivor><septic therapy><septic treatment><severe sepsis><severely septic><sex><sham therapy><single nucleotide variant><small molecule><subjects with sepsis><survive sepsis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><trans acting element><treat sepsis><treatment arm><vasopressor><whole genome><whole genome association analysis><whole genome association study>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Tamar Sofer

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Exploratory lead · 20/100
Solid budget
Active award
$256,785
FY 2025

Project Title

Genetically Linked Metabolites of Sepsis Severity and Mortality

Grant Number:

1R21HL181071-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2025

End Date:

8/31/2027

Project Abstract

Sepsis and its consequences such as organ dysfunction and failure remain significant human health problems. We have identified blood metabolites (small molecular weight compounds) including a by-product of mitochondrial fatty acid β-oxidation, acetylcarnitine (C2), that are associated with sepsis-in...

Research Terms

<Acetyl Carnitine><Acetylcarnitine><Age><American><Attenuated><BMI><BMI percentile><BMI z-score><Biological><Blood><Blood Plasma><Blood Reticuloendothelial System><Body mass index><Cell Body><Cells><Chronic><Clinical><Clinical Trials><Critical Illness><Critically Ill><DNA><Data><Data Set><Deoxyribonucleic Acid><Diabetes Mellitus><Disease><Disorder><Drug Targeting><Drug Therapy><Dysfunction><Exploratory/Developmental Grant><Failure><Fatty Acids><Functional disorder><Future><GWA study><GWAS><Gene variant><Genes><Genetic><Genomics><Health><Heterogeneity><Human><Hypotension><Inflammatory><Intermediary Metabolism><Knowledge><L Carnitine><Levocarnitine><Link><Liquid substance><Low Blood Pressure><Measures><Metabolic><Metabolic Processes><Metabolism><Mitochondria><Modern Man><Molecular><Molecular Weight><NHLBI><National Heart, Lung, and Blood Institute><Organ><Outcome><Participant><Patients><Pharmacological Treatment><Pharmacotherapy><Physiologic><Physiological><Physiopathology><Placebos><Plasma><Plasma Serum><Process><Quetelet index><R21 Mechanism><R21 Program><Regulation><Regulator Genes><Research Specimen><Resuscitation><Reticuloendothelial System, Serum, Plasma><Sepsis><Severities><Sham Treatment><Single Base Polymorphism><Single Nucleotide Polymorphism><Specimen><Survivors><Testing><Transcriptional Regulatory Elements><Vascular Hypotensive Disorder><Vasoactive Agonists><Vasoconstrictor Agents><Vasoconstrictor Drugs><Vasoconstrictors><Vasopressor Agents><Vitamin B T><Work><acylcarnitine><ages><allelic variant><antisepsis treatment><attenuate><attenuates><attenuation><biologic><clinical trial enrollment><co-morbid><co-morbidity><cohort><comorbidity><crystalloid><cytokine><diabetes><drug intervention><drug treatment><entire genome><exploratory developmental study><fluid><full genome><genetic association><genetic trans acting element><genetic variant><genome sequencing><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic data><genomic dataset><genomic variant><high risk><individuals with sepsis><insight><intervention arm><liquid><metabolism measurement><metabolomics><metabonomics><mitochondrial><mortality><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><oxidation><pathophysiology><patients with sepsis><people with sepsis><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><primary end point><primary endpoint><randomized, clinical trials><regulatory gene><secondary analysis><sepsis care><sepsis groups><sepsis interventions><sepsis management><sepsis patients><sepsis population><sepsis subjects><sepsis survivor><sepsis survivorship><sepsis therapeutics><sepsis therapy><sepsis treatment><septic group><septic individuals><septic patients><septic people><septic population><septic subject><septic survival><septic survivor><septic therapy><septic treatment><severe sepsis><severely septic><sex><sham therapy><single nucleotide variant><small molecule><subjects with sepsis><survive sepsis><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><trans acting element><treat sepsis><treatment arm><vasopressor><whole genome><whole genome association analysis><whole genome association study>
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Mandana Arbab

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Exploratory lead · 16/100
Active award
$249,000
FY 2026

Project Title

Precision Base Editing for the Treatment of Motor Neuron Diseases

Grant Number:

5R00NS119743-05

Activity Code:

R00

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2021

End Date:

12/31/2026

Project Abstract

Motor neuron diseases (MNDs) such as spinal muscular atrophy (SMA) and amyotrophic lateral sclerosis (ALS) are a class of progressive neurodegeneration disorders, often caused by minor genetic abnormalities to which motor neurons are particularly vulnerable. Because each of these diseases is rare an...

Research Terms

<21+ years old><AAV delivered><AAV delivery><AAV-based delivery><AAV-based viral delivery><AAV-mediated delivery><ASO therapeutics><ASO therapy><ASO treatment><Acceleration><Address><Adeno-associated-virus-based delivery><Adult><Adult Human><Affect><Alleles><Allelomorphs><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Animal Model><Animal Models and Related Studies><Antisense Oligonucleotide Therapy><Aran-Duchenne disease><Award><BCAR1><BCAR1 Protein><BCAR1 gene><Body Tissues><Breast Cancer Anti-Estrogen Resistance 1 Protein><CKRAS protein><CNS Nervous System><CRK-Associated Substrate><CRKAS><Cas protein><Cell Death><Central Nervous System><Chimera Protein><Chimeric Proteins><Chromosomal, Gene, or Protein Abnormality><Clinic><Communication><Complex><Cruveilhier disease><Cytogenetic or Molecular Genetic Abnormality><DNA mutation><Data><Deaminase><Degenerative Neurologic Disorders><Development><Disease><Disease-Free Survival><Disorder><Environment><Enzyme Gene><Enzymes><Event-Free Survival><Faculty><Foundations><Funding><Fusion Protein><Future><Gehrig's Disease><Gene Alteration><Gene Mutation><Gene variant><Genes><Genetic><Genetic Abnormality><Genetic Change><Genetic defect><Genetic mutation><Genome><Genomics><Genotype><Goals><Grant><Human><In Vitro><Individual><Injections><Investigators><Late-Onset Disorder><Learning><Libraries><Lou Gehrig Disease><Mammalian Cell><Mentorship><Methods><Mice><Mice Mammals><Modeling><Modern Man><Molecular Abnormality><Motor Cell><Motor Neuron Disease><Motor Neurons><Mouse ES Cell><Mouse ESC><Mouse Embryonic Progenitor><Mouse Embryonic Stem Cells><Murine><Mus><Mutation><NIH><National Institutes of Health><Neonatal><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neuraxis><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><North America><Nucleotides><Other Genetics><Outcome><Pathogenicity><Patients><Peripheral><Phenotype><Point Mutation><Position><Positioning Attribute><Procedures><Protocol><Protocols documentation><Publishing><Research><Research Personnel><Researchers><Route><Safety><Science><Serotyping><Spinal Muscular Atrophy><System><Techniques><Testing><Therapeutic><Therapeutic Gene Editing><Therapeutic Intervention><Tissues><Translating><Treatment Efficacy><United States National Institutes of Health><Validation><Variant><Variation><Work><Writing><adeno-associated viral vector delivery><adeno-associated virus delivery><adeno-associated virus mediated delivery><adenovirus mediated delivery><adulthood><allelic variant><anti-sense oligonucleotide drug><anti-sense oligonucleotide therapy><anti-sense oligonucleotide treatment><anti-sense therapy><antisense drug><antisense oligonucleotide therapeutic><antisense therapeutics><antisense therapy><base editing><base editor><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><community based design><community based research><computer based prediction><conference><convention><data visualization><degenerative diseases of motor and sensory neurons><degenerative disorder of motor neurons><degenerative neurological diseases><delivered with AAV><delivery with AAV><design><designing><developmental><disease causing variant><disease model><disease phenotype><disease-causing allele><disease-causing mutation><disorder model><experiment><experimental research><experimental study><experiments><fALS><familial ALS><familial amyotrophic lateral sclerosis><gene corrected><gene correction><gene defect><gene locus><gene-editing therapy><genetic locus><genetic variant><genome editing><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genome mutation><genomic correction><genomic editing><genomic location><genomic locus><genomic variant><improved><in vivo><intervention efficacy><intervention therapy><late disease onset><late onset disorder><mESC><machine learning based prediction model><machine learning based predictive model><machine learning prediction><machine learning prediction model><meeting><meetings><member><model of animal><molecular aberrations><molecular pathology><molecular phenotype><motoneuron><mouse model><murine ES cells><murine ESC><murine embryonic progenitor><murine embryonic stem cell><murine model><mutant allele><necrocytosis><neurodegenerative illness><novel><p130 cas protein><p130CAS><pathogenic allele><pathogenic variant><predictive modeling><progressive neurodegeneration><screening><screenings><skills><success><summit><symposia><symposium><therapeutic agent development><therapeutic development><therapeutic editing><therapeutic efficacy><therapeutic genome editing><therapy efficacy><tool><transversion mutation><validations>
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Karli Rae Hochstatter

FRIENDS RESEARCH INSTITUTE, INC., BALTIMORE, MD

Exploratory lead · 16/100
Active award
$236,700
FY 2026

Project Title

Leveraging a time-limited opportunity to study the impact of an intervention for individuals bereaved by drug overdose

Grant Number:

5R21DA062508-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Project Abstract

The ongoing opioid epidemic has created a large number of people who have lost family, friends, or other close peers to drug overdose. People bereaved by overdose often experience psychological stressors and disruptions to life, and are at greater risk of experiencing more severe grief symptoms, sub...

Research Terms

<21+ years old><Address><Adult><Adult Human><American><Anxiety><Awareness><Bereavement><Cessation of life><Control Groups><Country><Data><Death><Development><Disease><Disorder><Drug usage><Drugs><Effectiveness of Interventions><Emotional><Ensure><Family><Frequencies><Friends><Funding><Future><Grief><Grief reaction><HEAL Initiative><Health><Health Promotion><Helping End Addiction Long-term><Helping to End Addiction Long-term><Hospital Admission><Hospitalization><Individual><Intervention><Interview><Investigation><Life><Literature><Logistics><Major Depressive Disorder><Measures><Medical Examiners><Medication><Mental Depression><Mental Health><Mental Hygiene><Methods><NIH><National Institutes of Health><New York City><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Outcome><Overdose><PTSD><Persons><Pharmaceutical Preparations><Population><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Preventative intervention><Prevention program><Process><Psychological Health><Public Health><Random Allocation><Random Selection><Randomized><Reporting><Research><Research Design><Research Resources><Resources><Risk><Risk Behaviors><Risk Reduction><Risky Behavior><Salutogenesis><Service delivery model><Service model><Services><Severities><Social Network><Social Service><Social Work><Social Workers><Social outcome><Social support><Speed><Structure><Study Type><Subgroup><Substance Use Disorder><Survey Instrument><Surveys><Symptoms><Time><Training><United States National Institutes of Health><Vulnerable Populations><Work><acceptability and feasibility><adulthood><at risk behavior><behavior change><care delivery model><clinical depression><coping><depression><design><designing><developmental><drug use><drug/agent><evidence base><experience><health care delivery model><high risk><improved><injury-related death><innovate><innovation><innovative><interest><intervention delivery><intervention design><intervention for prevention><loved ones><major depression><major depression disorder><member><mortality><motivational enhancement therapy><motivational interview><non-medical opioid use><nonmedical opioid use><opiate crisis><opiate misuse><opioid addiction><opioid crisis><opioid dependence><opioid dependent><opioid epidemic><opioid misuse><outreach><overdose death><overdose fatalities><overdose risk><peer><physical conditioning><physical health><poor health outcome><post-trauma stress disorder><posttrauma stress disorder><prevent substance misuse><prevention intervention><preventional intervention strategy><preventive intervention><promoting health><psychological distress><psychological stresses><psychological stressor><randomisation><randomization><randomly assigned><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduced health outcome><reduces risk><reduces the risk><reducing risk><reducing the risk><response><risk-reducing><service delivery><social integration><social support network><study design><substance misuse><substance misuse prevention><substance use><substance use and disorder><substance using><success><therapy design><traumatic neurosis><treatment design><universal interventions><universal prevention><universal preventive interventions><universal preventive measure><vulnerable group><vulnerable individual><vulnerable people><worse health outcome>
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SARAH FORTUNE

HARVARD UNIVERSITY D/B/A HARVARD SCHOOL OF PUBLIC HEALTH, BOSTON, MA

Exploratory lead · 16/100
Active award
$232,050
FY 2026

Project Title

Identifying the drivers of ESX1 evolution in Mycobacterium tuberculosis

Grant Number:

5R21AI187884-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/12/2024

End Date:

10/31/2026

Project Abstract

Project Summary Even in trial settings, 5-10% of patients with uncomplicated, drug sensitive TB fail treatment. Data from our lab and others suggest that there are bacterial determinants of treatment response, in addition to high level drug resistance, which contribute to the variability in treatmen...

Research Terms

<Alleles><Allelomorphs><Antibiotic Agents><Antibiotic Drugs><Antibiotic Resistance><Antibiotics><Antigens><Attenuated><BALB C Mouse><BALB/c><Bone Marrow><Bone Marrow Reticuloendothelial System><Cell Mediated Immunology><Cell-Mediated Immunity><Cellular Immunity><Clinical><Code><Coding System><DNA mutation><Data><Disease><Disorder><Dissection><Drug Tolerance><Drug resistance><Drugs><ELF3><ELF3 gene><EPR-1><ERT gene><ERT protein><ESE-1><ESX><Environment><Epidemiology><Evolution><Future><Genes><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genomics><Granuloma><Granulomatous Lesion><Human><Immune><Immune system><Immunes><Immunity><In Vitro><Inbred BALB C Mice><Infection><M tb><M tuberculosis><M tuberculosis infection><M. tb><M. tb infection><M. tuberculosis><M. tuberculosis infection><M.tb infection><M.tuberculosis infection><MTB infection><MTB vaccine><Macrophage><Mediating><Medication><Mice><Mice Mammals><Miscellaneous Antibiotic><Modeling><Modern Man><Murine><Mus><Mutation><Mycobacterium tuberculosis><Mycobacterium tuberculosis (MTB) infection><Mycobacterium tuberculosis infection><Mφ><Necrosis><Necrotic><Outcome><Patients><Persons><Pharmaceutical Preparations><Phylogenetic Analysis><Phylogenetics><Population><Predisposition><Recurrence><Recurrent><Regulation><Resistance><Resistance to antibiotics><Resistant to antibiotics><Role><Susceptibility><System><T-Cells><T-Lymphocyte><TB infection><TB vaccine><Testing><Treatment Failure><Treatment outcome><Tuberculosis><Tuberculosis Vaccines><Vaccine for TB><Vaccine for Tuberculosis><Variant><Variation><Virulence><Work><anti-TB vaccine><anti-microbial><antibiotic drug resistance><antibiotic resistant><antimicrobial><attenuate><attenuates><bacterial genetics><clinical effect><disseminated TB><disseminated tuberculosis><drug resistant><drug-sensitive><drug/agent><epidemiologic><epidemiological><fitness><genetic approach><genetic strategy><genome mutation><immunogen><in vivo><infection due to Mycobacterium tuberculosis><loss of function><mouse model><mtb><murine model><new drug class><novel drug class><pathogenicity gene><pressure><resilience><resilient><resistance gene><resistance locus><resistance mutation><resistance to Drug><resistant><resistant gene><resistant mutation><resistant to Drug><response><response to therapy><response to treatment><social role><therapeutic response><therapy failure><therapy response><thymus derived lymphocyte><timeline><trait><treatment response><treatment responsiveness><tuberculosis infection><tuberculous spondyloarthropathy><vaccine against M. tuberculosis><vaccine against Mtb><vaccine against Mycobacterium tuberculosis><vaccine against TB><vaccine against tuberculosis><vaccine candidates against tuberculosis><vaccine response><vaccine responsiveness><vaccine-induced response><virulence gene><virulent gene>
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EDWIN TED G. ABEL

UNIVERSITY OF IOWA, IOWA CITY, IA

Exploratory lead · 16/100
Active award
$231,350
FY 2026

Project Title

Elucidating learning-induced molecular signatures in hippocampal mature oligodendrocytes at single-cell and spatial resolution: Implications for hippocampal function

Grant Number:

1R21NS143268-01A1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2026

End Date:

1/31/2028

Project Abstract

Project Summary/Abstract Neuronal plasticity is fundamental for cognitive and behavioral processes. Emerging evidence has shed light on the role of oligodendrocytes in regulating activity-dependent plasticity. Although primarily recognized for their role in forming myelin, mature oligodendrocytes al...

Research Terms

<Affect><Ammon Horn><Applications Grants><Assay><Behavior><Behavioral><Bioassay><Biological Assay><CNS plasticity><Calcium><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cells><Characteristics><Chromatin><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Cornu Ammonis><Coupled><D-Glucose><Data><Degenerative Neurologic Disorders><Development><Dextrose><Disturbance in cognition><Dorsal><Dysfunction><Exhibits><Exploratory/Developmental Grant><Expression Signature><Fiber><Foundations><Functional disorder><Future><Gene Expression><Gene Expression Profile><Genes><Glucose><Grant Proposals><Harvest><Heterogeneity><Hippocampus><Hour><Impaired cognition><In Situ><Intracellular Communication and Signaling><Investigation><Label><Learning><Link><Memory><Metabolic><Molecular><Molecular Fingerprinting><Molecular Profiling><Myelin><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Nervous System Diseases><Nervous System Disorder><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurodevelopmental Disorder><Neurologic Degenerative Conditions><Neurologic Disorders><Neurological Development Disorder><Neurological Disorders><Neuronal Plasticity><Neurons><Nucleus><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Outcome><Pattern><Photometry><Physiopathology><Process><Protein-Serine Kinase><Protein-Serine-Threonine Kinases><Protein-Threonine Kinase><R21 Mechanism><R21 Program><Regulation><Reporting><Research><Resolution><Role><Serine Kinase><Serine-Threonine Kinases><Serine/Threonine Protein Kinase Gene><Signal Transduction><Signal Transduction Systems><Signaling><Techniques><Testing><Therapeutic Intervention><Threonine Kinase><Training><Transcript><Transgenic Mice><Upregulation><Viral><Work><biological signal transduction><candidate selection><cell type><central nervous system plasticity><cognitive defects><cognitive dysfunction><cognitive loss><cognitive process><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><differential expression><differentially expressed><energy efficiency><epigenomics><experience><experiment><experimental research><experimental study><experiments><exploratory developmental study><gene expression pattern><gene expression signature><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><hippocampal><hippocampal subregions><in vivo><in vivo Model><insight><intervention therapy><long-term memory><memory consolidation><molecular profile><molecular signature><multiomics><multiple omics><myelination><neural plasticity><neurodegenerative illness><neurodevelopmental disease><neurological disease><neuronal><neuronal circuit><neuronal circuitry><neurophysiological><neurophysiology><neuroplastic><neuroplasticity><neuropsychiatric disease><neuropsychiatric disorder><new approaches><novel><novel approaches><novel strategies><novel strategy><panomics><pathophysiology><programs><resolutions><response><scRNA sequencing><scRNA-seq><segregation><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spatial memory><substantia alba><therapeutic target><transcriptional differences><transcriptional profile><transcriptional signature><transcriptome profiling><transcriptomic profiling><transcriptomics><white matter>
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Marius George Linguraru

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 16/100
Active award
$221,730
FY 2026

Project Title

Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings

Grant Number:

5R33HD102988-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

SUMMARY Congenital anomalies represent an increasing burden of disease worldwide, accounting for millions of birth defect-related disabilities with a disproportionate impact on Low to Middle Income Countries (LIMCs). Many harbor genetic etiologies, for which no confirmatory diagnosis can be made due...

Research Terms

<0-11 years old><0-4 weeks old><AI Augmented><AI assisted><AI based><AI driven><AI enhanced><AI integrated><AI model training><AI powered><AI system><AI technology><AI training><Accounting><Active Follow-up><Address><Affect><Android App><Android Application><Aneuploid><Aneuploidy><Appearance><Artificial Intelligence><Artificial Intelligence enhanced><Artificial intelligence model training><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Belgian Congo><Biometrics><Biometry><Biostatistics><Birth Defects><Birth Rate><Bucca><Capillary Electrophoresis><Capillary Electrophoresis Fractionation><Caring><Cell Phone><Cell Phone Application><Cell phone App><Cellular Phone><Cellular Phone App><Cellular Phone Application><Cellular Telephone><Cheek><Cheek structure><Child><Child Mortality><Child Youth><Children (0-21)><Competence><Computer Reasoning><Computer software><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Cardiac Defects><Congenital Defects><Congenital Deformity><Congenital Heart Defects><Congenital Malformation><Copy Number Polymorphism><Country><Coupled><DNA seq><DNA sequencing><DNAseq><Data><Data Bases><Databases><Democratic Republic of the Congo><Detection><Development><Diagnosis><Diagnostic><Disease><Disorder><Down Syndrome><Early Diagnosis><Economic Income><Economical Income><Environment><Environmental Factor><Environmental Risk Factor><Ethics><Ethnic Origin><Ethnicity><Face><Family><Fellowship><Future><General Population><General Public><Genetic><Genetic Diseases><Genetic Materials><Health><Health Care><Health Care Providers><Health Personnel><Hearing><High Prevalence><Hospitals><Income><Individual><Infection><Infrastructure><International><Intervention><Laboratories><Langdon Down syndrome><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Machine Intelligence><Machine Learning><Materials Testing><Measures><Mobile Phones><Modeling><Mongolism><Morbidity><Morphology><Neonatal Screening><Newborn Infant><Newborn Infant Screening><Newborns><Nutrition><Other Genetics><Outcome><Patient risk><Persons><Phenotype><Photography><Physicians><Pilot Projects><Point Mutation><Population><Population Heterogeneity><Population Surveillance><Prevalence><Public Health><Public Health Surveillance><Publications><Registries><Research Institute><Research Resources><Resource Allocation><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Sampling><Scientific Publication><Services><Smart Phone App><Smart Phone Application><Smartphone App><Societies><Software><Students><Surveillance Program><Swab><Syndrome><System><Technology><Testing><Time><Training><Trisomy 21><Washington><Zaire><accurate diagnosis><active followup><app on a smartphone><application on a smartphone><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence based><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><artificial intelligence technology><artificial intelligence training><burden of disease><burden of illness><cell phone based app><chromosome 21 trisomy><chromosome 21 trisomy syndrome><computer scientist><computerized><congenital acromicria syndrome><congenital anomaly><copy number variant><copy number variation><cost><data acquisition><data acquisitions><data base><data registry><death risk><design><designing><developmental><diagnostic screening><diagnostic technologies><disability><disease burden><diverse populations><early detection><empowerment><enhanced with AI><enhanced with Artificial Intelligence><environmental risk><ethical><faces><facial><facial recognition software><follow up><follow-up><followed up><followup><gene-based diagnostics><genetic condition><genetic diagnosis><genetic diagnostics><genetic disorder><genetic disorder diagnosis><genetic etiology><genetic mechanism of disease><genetic resource><genetic-focused diagnostic><global health><health care personnel><health care quality><health care service><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><heterogeneous population><iOS app><iOS application><iPhone><iPhone App><iPhone Application><improved><incomes><indel><innovate><innovation><innovative><innovative technologies><insertion/deletion><insertion/deletion mutation><intervention program><kids><mHealth therapeutic><mHealth therapy><mHealth treatment><machine based learning><medical care providers><medical personnel><mhealth interventions><mobile DNA><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mobile phone app><morbus Down><mortality risk><neonatal health><new approaches><newborn child><newborn children><newborn health><newborn screening><novel><novel approaches><novel strategies><novel strategy><phone app><phone application><pilot study><point of care><population diversity><prevent><preventing><programs><pseudohypertrophic progressive muscular dystrophy><rapid diagnosis><screening><screenings><smart phone><smartphone><smartphone application><smartphone based app><smartphone based application><standard of care><tool><transposon/insertion element><treatment provider><trisomy 21 syndrome><youngster>
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Ngoyi Mumba

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 16/100
Active award
$221,730
FY 2026

Project Title

Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings

Grant Number:

5R33HD102988-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

SUMMARY Congenital anomalies represent an increasing burden of disease worldwide, accounting for millions of birth defect-related disabilities with a disproportionate impact on Low to Middle Income Countries (LIMCs). Many harbor genetic etiologies, for which no confirmatory diagnosis can be made due...

Research Terms

<0-11 years old><0-4 weeks old><AI Augmented><AI assisted><AI based><AI driven><AI enhanced><AI integrated><AI model training><AI powered><AI system><AI technology><AI training><Accounting><Active Follow-up><Address><Affect><Android App><Android Application><Aneuploid><Aneuploidy><Appearance><Artificial Intelligence><Artificial Intelligence enhanced><Artificial intelligence model training><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Belgian Congo><Biometrics><Biometry><Biostatistics><Birth Defects><Birth Rate><Bucca><Capillary Electrophoresis><Capillary Electrophoresis Fractionation><Caring><Cell Phone><Cell Phone Application><Cell phone App><Cellular Phone><Cellular Phone App><Cellular Phone Application><Cellular Telephone><Cheek><Cheek structure><Child><Child Mortality><Child Youth><Children (0-21)><Competence><Computer Reasoning><Computer software><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Cardiac Defects><Congenital Defects><Congenital Deformity><Congenital Heart Defects><Congenital Malformation><Copy Number Polymorphism><Country><Coupled><DNA seq><DNA sequencing><DNAseq><Data><Data Bases><Databases><Democratic Republic of the Congo><Detection><Development><Diagnosis><Diagnostic><Disease><Disorder><Down Syndrome><Early Diagnosis><Economic Income><Economical Income><Environment><Environmental Factor><Environmental Risk Factor><Ethics><Ethnic Origin><Ethnicity><Face><Family><Fellowship><Future><General Population><General Public><Genetic><Genetic Diseases><Genetic Materials><Health><Health Care><Health Care Providers><Health Personnel><Hearing><High Prevalence><Hospitals><Income><Individual><Infection><Infrastructure><International><Intervention><Laboratories><Langdon Down syndrome><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Machine Intelligence><Machine Learning><Materials Testing><Measures><Mobile Phones><Modeling><Mongolism><Morbidity><Morphology><Neonatal Screening><Newborn Infant><Newborn Infant Screening><Newborns><Nutrition><Other Genetics><Outcome><Patient risk><Persons><Phenotype><Photography><Physicians><Pilot Projects><Point Mutation><Population><Population Heterogeneity><Population Surveillance><Prevalence><Public Health><Public Health Surveillance><Publications><Registries><Research Institute><Research Resources><Resource Allocation><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Sampling><Scientific Publication><Services><Smart Phone App><Smart Phone Application><Smartphone App><Societies><Software><Students><Surveillance Program><Swab><Syndrome><System><Technology><Testing><Time><Training><Trisomy 21><Washington><Zaire><accurate diagnosis><active followup><app on a smartphone><application on a smartphone><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence based><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><artificial intelligence technology><artificial intelligence training><burden of disease><burden of illness><cell phone based app><chromosome 21 trisomy><chromosome 21 trisomy syndrome><computer scientist><computerized><congenital acromicria syndrome><congenital anomaly><copy number variant><copy number variation><cost><data acquisition><data acquisitions><data base><data registry><death risk><design><designing><developmental><diagnostic screening><diagnostic technologies><disability><disease burden><diverse populations><early detection><empowerment><enhanced with AI><enhanced with Artificial Intelligence><environmental risk><ethical><faces><facial><facial recognition software><follow up><follow-up><followed up><followup><gene-based diagnostics><genetic condition><genetic diagnosis><genetic diagnostics><genetic disorder><genetic disorder diagnosis><genetic etiology><genetic mechanism of disease><genetic resource><genetic-focused diagnostic><global health><health care personnel><health care quality><health care service><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><heterogeneous population><iOS app><iOS application><iPhone><iPhone App><iPhone Application><improved><incomes><indel><innovate><innovation><innovative><innovative technologies><insertion/deletion><insertion/deletion mutation><intervention program><kids><mHealth therapeutic><mHealth therapy><mHealth treatment><machine based learning><medical care providers><medical personnel><mhealth interventions><mobile DNA><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mobile phone app><morbus Down><mortality risk><neonatal health><new approaches><newborn child><newborn children><newborn health><newborn screening><novel><novel approaches><novel strategies><novel strategy><phone app><phone application><pilot study><point of care><population diversity><prevent><preventing><programs><pseudohypertrophic progressive muscular dystrophy><rapid diagnosis><screening><screenings><smart phone><smartphone><smartphone application><smartphone based app><smartphone based application><standard of care><tool><transposon/insertion element><treatment provider><trisomy 21 syndrome><youngster>
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Eric J. Vilain

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 16/100
Active award
$221,730
FY 2026

Project Title

Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings

Grant Number:

5R33HD102988-04

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

SUMMARY Congenital anomalies represent an increasing burden of disease worldwide, accounting for millions of birth defect-related disabilities with a disproportionate impact on Low to Middle Income Countries (LIMCs). Many harbor genetic etiologies, for which no confirmatory diagnosis can be made due...

Research Terms

<0-11 years old><0-4 weeks old><AI Augmented><AI assisted><AI based><AI driven><AI enhanced><AI integrated><AI model training><AI powered><AI system><AI technology><AI training><Accounting><Active Follow-up><Address><Affect><Android App><Android Application><Aneuploid><Aneuploidy><Appearance><Artificial Intelligence><Artificial Intelligence enhanced><Artificial intelligence model training><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Belgian Congo><Biometrics><Biometry><Biostatistics><Birth Defects><Birth Rate><Bucca><Capillary Electrophoresis><Capillary Electrophoresis Fractionation><Caring><Cell Phone><Cell Phone Application><Cell phone App><Cellular Phone><Cellular Phone App><Cellular Phone Application><Cellular Telephone><Cheek><Cheek structure><Child><Child Mortality><Child Youth><Children (0-21)><Competence><Computer Reasoning><Computer software><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Cardiac Defects><Congenital Defects><Congenital Deformity><Congenital Heart Defects><Congenital Malformation><Copy Number Polymorphism><Country><Coupled><DNA seq><DNA sequencing><DNAseq><Data><Data Bases><Databases><Democratic Republic of the Congo><Detection><Development><Diagnosis><Diagnostic><Disease><Disorder><Down Syndrome><Early Diagnosis><Economic Income><Economical Income><Environment><Environmental Factor><Environmental Risk Factor><Ethics><Ethnic Origin><Ethnicity><Face><Family><Fellowship><Future><General Population><General Public><Genetic><Genetic Diseases><Genetic Materials><Health><Health Care><Health Care Providers><Health Personnel><Hearing><High Prevalence><Hospitals><Income><Individual><Infection><Infrastructure><International><Intervention><Laboratories><Langdon Down syndrome><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Machine Intelligence><Machine Learning><Materials Testing><Measures><Mobile Phones><Modeling><Mongolism><Morbidity><Morphology><Neonatal Screening><Newborn Infant><Newborn Infant Screening><Newborns><Nutrition><Other Genetics><Outcome><Patient risk><Persons><Phenotype><Photography><Physicians><Pilot Projects><Point Mutation><Population><Population Heterogeneity><Population Surveillance><Prevalence><Public Health><Public Health Surveillance><Publications><Registries><Research Institute><Research Resources><Resource Allocation><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Sampling><Scientific Publication><Services><Smart Phone App><Smart Phone Application><Smartphone App><Societies><Software><Students><Surveillance Program><Swab><Syndrome><System><Technology><Testing><Time><Training><Trisomy 21><Washington><Zaire><accurate diagnosis><active followup><app on a smartphone><application on a smartphone><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence based><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><artificial intelligence technology><artificial intelligence training><burden of disease><burden of illness><cell phone based app><chromosome 21 trisomy><chromosome 21 trisomy syndrome><computer scientist><computerized><congenital acromicria syndrome><congenital anomaly><copy number variant><copy number variation><cost><data acquisition><data acquisitions><data base><data registry><death risk><design><designing><developmental><diagnostic screening><diagnostic technologies><disability><disease burden><diverse populations><early detection><empowerment><enhanced with AI><enhanced with Artificial Intelligence><environmental risk><ethical><faces><facial><facial recognition software><follow up><follow-up><followed up><followup><gene-based diagnostics><genetic condition><genetic diagnosis><genetic diagnostics><genetic disorder><genetic disorder diagnosis><genetic etiology><genetic mechanism of disease><genetic resource><genetic-focused diagnostic><global health><health care personnel><health care quality><health care service><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><heterogeneous population><iOS app><iOS application><iPhone><iPhone App><iPhone Application><improved><incomes><indel><innovate><innovation><innovative><innovative technologies><insertion/deletion><insertion/deletion mutation><intervention program><kids><mHealth therapeutic><mHealth therapy><mHealth treatment><machine based learning><medical care providers><medical personnel><mhealth interventions><mobile DNA><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mobile phone app><morbus Down><mortality risk><neonatal health><new approaches><newborn child><newborn children><newborn health><newborn screening><novel><novel approaches><novel strategies><novel strategy><phone app><phone application><pilot study><point of care><population diversity><prevent><preventing><programs><pseudohypertrophic progressive muscular dystrophy><rapid diagnosis><screening><screenings><smart phone><smartphone><smartphone application><smartphone based app><smartphone based application><standard of care><tool><transposon/insertion element><treatment provider><trisomy 21 syndrome><youngster>
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Santiago Correa

COLUMBIA UNIV NEW YORK MORNINGSIDE, NEW YORK, NY

Exploratory lead · 16/100
Active award
$219,981
FY 2026

Project Title

Lymph node inspired hydrogels for immune cell reprogramming

Grant Number:

5R21EB034818-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2025

End Date:

1/31/2028

Project Abstract

Summary Abstract This proposal combines the fields of DNA origami, colloids, and supramolecular hydrogels to develop biomimetic scaffolds to transform the way we engineer T cells for cellular immunotherapy. Cell therapies have broad biomedical potential, spanning application areas as diverse as canc...

Research Terms

<3-D><3-Dimensional><3D><Address><Animals><Antigen-Presenting Cells><Antigens><Area><Assay><Autoantigens><Autoimmune Diseases><Autologous Antigens><Bioassay><Biochemical><Biocompatible Materials><Biological Assay><Biological Mimetics><Biomaterials><Biomimetics><Biopolymers><Body Tissues><Cancer Treatment><Cancers><Cardiovascular Diseases><Cell Body><Cell Communication and Signaling><Cell Locomotion><Cell Migration><Cell Movement><Cell Reprogramming><Cell Signaling><Cell Therapy><Cell-Extracellular Matrix><Cells><Cellular Migration><Cellular Motility><Cellular immunotherapy><Chemistry><Clinical><Co-culture><Cocultivation><Coculture><Coculture Techniques><Colloids><Complex><Cues><DNA><DNA Integration><Dancing><Deoxyribonucleic Acid><Disease><Disorder><ECM><Engineering><Environment><Extracellular Matrix><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Funding><Gene Delivery><Goals><Histocompatibility Complex><Histocompatibility Complices><Human><Hydrogels><Immune><Immunes><Immunoassay><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunology><Immunomodulation><Immunosuppressed Host><Individual><Injectable><Intracellular Communication and Signaling><Lead><Length><Life><Ligands><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphatic nodes><Major Histocompatibility Complex><Major Histocompatibility Complices><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Mechanics><Medical><Methods><Modern Man><Molecular><Nanostructures><Nucleic Acids><Organism><Patients><Pattern><Pb element><Peptides><Phenotype><Position><Positioning Attribute><Procedures><Process><Production><Research><Self-Antigens><Signal Transduction><Signal Transduction Systems><Signaling><Solid Neoplasm><Solid Tumor><Structure><Surface><Synapses><Synaptic><System><T cell based immune therapy><T cell based therapeutics><T cell based therapy><T cell directed therapies><T cell immune therapy><T cell immunotherapy><T cell targeted therapeutics><T cell therapy><T cell treatment><T cell-based immunotherapy><T cell-based treatment><T cellular immunotherapy><T cellular therapy><T lymphocyte based immunotherapy><T lymphocyte based therapy><T lymphocyte therapeutic><T lymphocyte treatment><T-Cell Activation><T-Cells><T-Lymphocyte><T-cell therapeutics><T-cell transfer therapy><Technical Expertise><Technology><Teen><Teenagers><Time><Tissues><Training><Tumor Expansion><Tumor-Infiltrating Lymphocytes><Viral Diseases><Virus Diseases><Work><accessory cell><activate T cells><adoptive T cell transfer><adoptive T lymphocyte transfer><adoptive T-cell therapy><anti-cancer therapy><antigen-specific T cells><autoimmune condition><autoimmune disorder><autoimmunity disease><biological material><biological signal transduction><cancer therapy><cancer-directed therapy><cardiovascular disorder><cell based intervention><cell mediated intervention><cell mediated therapies><cell motility><cell-based immunotherapy><cell-based therapeutic><cell-based therapy><cellular reprogramming><cellular therapeutic><cellular therapy><cost><cytokine><design><designing><engineered T cells><experience><fitness><flow cytophotometry><genetically engineered T-cells><heavy metal Pb><heavy metal lead><immune cell therapy><immune modulation><immune regulation><immunogen><immunologic reactivity control><immunological synapse><immunomodulatory><immunoregulation><immunoregulatory><immunosuppressed patient><improved><in vivo><innovate><innovation><innovative><living system><lymph gland><lymph nodes><lymphnodes><malignancy><manufacture><mechanic><mechanical><mimicry><molecular imaging><molecule imaging><nano><nano medicinal><nano medicine><nano meter scale><nano meter sized><nano-sized structures><nano-structures><nanofabricate><nanofabrication><nanomedicinal><nanomedicine><nanometer scale><nanometer sized><nanoscale><neoplasm/cancer><particle><pre-clinical><preclinical><programs><prototype><recruit><scaffold><scaffolding><self assembly><success><synapse><technical skills><technology platform><technology system><teen years><teenage><therapeutic T-cell platform><three dimensional><thymus derived lymphocyte><tissue culture><tool><transgenic T- cells><tumor><viral infection><virus infection><virus-induced disease>
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James Daniel Lord

BENAROYA RESEARCH INST AT VIRGINIA MASON, SEATTLE, WA

Exploratory lead · 16/100
Active award
$216,625
FY 2026

Project Title

Characterizing circulating and visceral T cells specific for the autoantigen integrin αvβ6 in ulcerative colitis

Grant Number:

5R21AI188483-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/4/2024

End Date:

11/30/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT The integrin heterodimer αvβ6 expressed on intestinal epithelial cells has recently been discovered as the target of autoantibodies uniquely found in nearly every patient with ulcerative colitis (UC), even years before disease onset. We propose to find and characterize the T...

Research Terms

<7S Gamma Globulin><Ab response><Abscission><Address><Affinity><Algorithms><American><Anatomic Sites><Anatomic structures><Anatomy><Antibodies><Antibody Formation><Antibody Production><Antigens><Archives><Assay><Autoantibodies><Autoantibody binding><Autoantibody reactivity><Autoantigens><Autologous><Autologous Antigens><Autoregulation><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Base Sequence><Binding><Bioassay><Biological Assay><Blood><Blood Cells><Blood Reticuloendothelial System><Blood Serum><Body Tissues><Bone-Derived Transforming Growth Factor><Brittle Diabetes Mellitus><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><CD51 Antigens><Cell Body><Cell Communication><Cell Interaction><Cell Isolation><Cell Line><Cell Segregation><Cell Separation><Cell Separation Technology><Cell-to-Cell Interaction><CellLine><Cells><Chronic><Clinical Data><Clonal Expansion><Colon><Colonic Diseases><Complex><Crohn disease><Crohn's><Crohn's disease><Crohn's disorder><Cryofixation><Cryopreservation><Data><Data Set><Diagnosis><Disease><Disorder><Epithelial Cells><Epithelium><Excision><Exploratory/Developmental Grant><Expression Signature><Extirpation><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Frequencies><Funding><Future><Gene Expression><Gene Expression Profile><Genomics><Granulomatous Enteritis><Homeostasis><Human><IDDM><IgG><Immune><Immune Tolerance><Immune memory><Immune system><Immunes><Immunoglobulin G><Immunologic Memory><Immunologic Subtyping><Immunologic Tolerance><Immunological Memory><Immunomodulation><Immunophenotyping><Individual><Inflammatory><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Institution><Insulin-Dependent Diabetes Mellitus><Integrin alphaV><Integrin αV><Integrins><Integrins Extracellular Matrix><Intestinal><Intestinal Mucosa><Intestines><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Learning><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphatic nodes><MHC Receptor><Major Histocompatibility Complex Receptor><Medical><Milk Growth Factor><Modern Man><Molecular Interaction><Morbidity><Mucosa><Mucosal Tissue><Mucous Membrane><Nucleotide Sequence><Onset of illness><Operative Procedures><Operative Surgical Procedures><Pathogenesis><Pathogenicity><Pathology><Patients><Peptides><Peripheral Blood Cell><Persons><Phenotype><Physiological Homeostasis><Platelet Transforming Growth Factor><Play><Position><Positioning Attribute><Proteins><Public Health><Qualifying><R21 Mechanism><R21 Program><RNA Seq><RNA sequencing><RNAseq><Receptors, Antigen, T-Cell, alpha-beta><Regulatory T-Lymphocyte><Removal><Research><Research Design><Role><Sampling><Self Tolerance><Self-Antigens><Serum><Strains Cell Lines><Study Type><Sudden-Onset Diabetes Mellitus><Surgical><Surgical Interventions><Surgical Procedure><Surgical Removal><Survey Instrument><Surveys><T cell clonality><T cell receptor repertoire sequencing><T cell receptor sequencing><T-Cell Antigen Receptors><T-Cell Receptor><T-Cells><T-Lymphocyte><T-cell receptor clonality><T1 DM><T1 diabetes><T1D><T1DM><T4 Cells><T4 Lymphocytes><TCR clonality><TCR repertoire sequencing><TCR sequencing><TCR-seq><TCRseq><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><TcR alpha-beta><TcR αβ><Techniques><Time><Tissues><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Treg><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Ulcerated Colitis><Ulcerative Colitis><Visceral><Work><alpha(V) Integrin><alpha-beta T-Cell Receptor><anamnestic reaction><antibody biosynthesis><autoimmune antibody><autoreactive T cell><autoreactive antibody><beta(6) integrin><biobank><biorepository><bowel><cell sorting><chronic inflammatory disease><cohort><cold preservation><cold storage><colon disorder><cultured cell line><cytokine><design><designing><disability><disease onset><disorder onset><eleocolitis><experience><exploratory developmental study><flow cytophotometry><gene expression pattern><gene expression signature><global gene expression><global transcription profile><high dimensional data><high reward><immune modulation><immune regulation><immune self tolerance><immune system tolerance><immune unresponsiveness><immunogen><immunoglobulin biosynthesis><immunologic reactivity control><immunological paralysis><immunomodulatory><immunoregulation><immunoregulatory><inflammatory disease of the intestine><inflammatory disorder of the intestine><insight><insulin dependent diabetes><insulin dependent type 1><integrin beta6><integrin β6><intestinal autoinflammation><intestinal epithelium><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><lymph gland><lymph nodes><lymphnodes><mesenteric lymph node><mesentery lymph node><multidimensional data><multidimensional datasets><novel><nucleic acid sequence><programs><regional enteritis><regulatory T-cells><resection><scRNA sequencing><scRNA-seq><secondary immune response><self reactive antibody><self-reactive T cell><single cell RNA-seq><single cell RNAseq><single cell analysis><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><study design><success><surgery><thymus derived lymphocyte><transcriptional profile><transcriptional signature><transcriptome><transcriptome sequencing><transcriptomic sequencing><type I diabetes><type one diabetes><αβ T-Cell Receptor>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Johanna Patricia Daily

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Exploratory lead · 16/100
Active award
$210,000
FY 2026

Project Title

Role of cytolytic ZEB2+ memory CD4+ T cells in protection against liver stage malaria

Grant Number:

5R21AI188626-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/14/2025

End Date:

12/31/2026

Project Abstract

Abstract Malaria remains a major human parasitic disease with over half a million deaths and 247 million cases every year. The WHO approved vaccines, RTS,S/AS01 (MosquirixTM) and R21/Matrix-M target the major Plasmodium falciparum (Pf) pre-erythrocytic stage circumsporozoite protein (CSP) antigen (A...

Research Terms

<0-11 years old><7S Gamma Globulin><Ab response><Adoptive Transfer><Affinity><Anemia><Antibodies><Antibody Formation><Antibody Production><Antigens><Attenuated><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Basal Transcription Factor><Basal transcription factor genes><Benchmarking><Best Practice Analysis><Blood><Blood Reticuloendothelial System><Blood erythrocyte><C-terminal><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Cessation of life><Child><Child Youth><Children (0-21)><Clinical><Clonal Expansion><Communication><Complex><Culicidae><Cytolysis><Data><Death><Differentation Markers><Differentiation Antigens><Differentiation Markers><Disease><Disorder><Erythrocytes><Erythrocytic><Falciparum Malaria><Fever><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><General Transcription Factor Gene><General Transcription Factors><Generations><Goals><Health><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Human><IgG><Immune><Immune Cell Activation><Immune response><Immune system><Immunes><Immunity><Immunization><Immunize><Immunoglobulin G><Impairment><Individual><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammation><Innate Immunity><Intravenous><Kinetics><Knock-out><Knockout><Knowledge><Kupffer Cells><Liver><Liver Cells><Lysis><Maintenance><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marker Antigens><Marrow erythrocyte><Mediating><Mediator><Mice><Mice Mammals><Modeling><Modern Man><Mosquitoes><Murine><Mus><Native Immunity><Natural Immunity><Nature><Non-Specific Immunity><Nonspecific Immunity><Nyasaland><Outcome><P falciparum><P. falciparum><P.falciparum><Paludism><Parasites><Parasitic Diseases><Patients><Phenotype><Plasmodium Infections><Plasmodium berghei><Plasmodium falciparum><Plasmodium falciparum Malaria><Population><Predisposition><Prospective Studies><Publishing><Pyrexia><Radiation><Reaction><Recommendation><Red Blood Cells><Red Cell><Reporter><Residencies><Risk><Role><Spleen><Spleen Reticuloendothelial System><Sporozoites><Stellate Sinusoidal Macrophage><Susceptibility><Symptoms><T cell differentiation><T4 Cells><T4 Lymphocytes><Technology><Testing><Time Study><Transcription Factor Proto-Oncogene><Transcription factor genes><Transmission><Vaccination><Vaccination acquired immunity><Vaccination induced immunity><Vaccines><Work><accumulated exposure><accumulated long-term exposure><acquired immunity><aggregate exposure><antibody biosynthesis><arm><attenuate><attenuates><benchmark><blood corpuscles><cell mediated immune response><circumsporozoite protein><cohort><cs protein><cumulative exposure><cumulative life exposure><cumulative long-term exposure><develop a vaccine><develop vaccines><development of a vaccine><experiment><experimental research><experimental study><experiments><febrile><febris><flow cytophotometry><hepatic body system><hepatic organ system><high dimensionality><host response><human model><immune activation><immune system response><immunogen><immunoglobulin biosynthesis><immunoresponse><improved><induced Cre><inducible Cre><insight><kids><life-course exposure><lifelong exposure><lifespan exposure><lifetime exposure><liver macrophage><memory CD4 T cell><memory CD4 T lymphocyte><model of human><mouse model><murine model><novel><prevent><preventing><prospective research study><prospective survey><response><rodent plasmodia><social role><totality of exposures><transcription factor><transcriptomics><transmission process><vaccine acquired immunity><vaccine associated immunity><vaccine candidate><vaccine development><vaccine efficacy><vaccine response><vaccine responsiveness><vaccine-induced immunity><vaccine-induced protection><vaccine-induced response><vaccines against malaria><youngster>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Gregoire Stephane Lauvau

ALBERT EINSTEIN COLLEGE OF MEDICINE, BRONX, NY

Exploratory lead · 16/100
Active award
$210,000
FY 2026

Project Title

Role of cytolytic ZEB2+ memory CD4+ T cells in protection against liver stage malaria

Grant Number:

5R21AI188626-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/14/2025

End Date:

12/31/2026

Project Abstract

Abstract Malaria remains a major human parasitic disease with over half a million deaths and 247 million cases every year. The WHO approved vaccines, RTS,S/AS01 (MosquirixTM) and R21/Matrix-M target the major Plasmodium falciparum (Pf) pre-erythrocytic stage circumsporozoite protein (CSP) antigen (A...

Research Terms

<0-11 years old><7S Gamma Globulin><Ab response><Adoptive Transfer><Affinity><Anemia><Antibodies><Antibody Formation><Antibody Production><Antigens><Attenuated><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Basal Transcription Factor><Basal transcription factor genes><Benchmarking><Best Practice Analysis><Blood><Blood Reticuloendothelial System><Blood erythrocyte><C-terminal><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cells><Cessation of life><Child><Child Youth><Children (0-21)><Clinical><Clonal Expansion><Communication><Complex><Culicidae><Cytolysis><Data><Death><Differentation Markers><Differentiation Antigens><Differentiation Markers><Disease><Disorder><Erythrocytes><Erythrocytic><Falciparum Malaria><Fever><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><General Transcription Factor Gene><General Transcription Factors><Generations><Goals><Health><Helper Cells><Helper T-Cells><Helper T-Lymphocytes><Helper-Inducer T-Cells><Helper-Inducer T-Lymphocyte><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Human><IgG><Immune><Immune Cell Activation><Immune response><Immune system><Immunes><Immunity><Immunization><Immunize><Immunoglobulin G><Impairment><Individual><Inducer Cells><Inducer T-Lymphocytes><Infection><Inflammation><Innate Immunity><Intravenous><Kinetics><Knock-out><Knockout><Knowledge><Kupffer Cells><Liver><Liver Cells><Lysis><Maintenance><Malaria><Malaria Vaccines><Malarial Vaccines><Malawi><Marker Antigens><Marrow erythrocyte><Mediating><Mediator><Mice><Mice Mammals><Modeling><Modern Man><Mosquitoes><Murine><Mus><Native Immunity><Natural Immunity><Nature><Non-Specific Immunity><Nonspecific Immunity><Nyasaland><Outcome><P falciparum><P. falciparum><P.falciparum><Paludism><Parasites><Parasitic Diseases><Patients><Phenotype><Plasmodium Infections><Plasmodium berghei><Plasmodium falciparum><Plasmodium falciparum Malaria><Population><Predisposition><Prospective Studies><Publishing><Pyrexia><Radiation><Reaction><Recommendation><Red Blood Cells><Red Cell><Reporter><Residencies><Risk><Role><Spleen><Spleen Reticuloendothelial System><Sporozoites><Stellate Sinusoidal Macrophage><Susceptibility><Symptoms><T cell differentiation><T4 Cells><T4 Lymphocytes><Technology><Testing><Time Study><Transcription Factor Proto-Oncogene><Transcription factor genes><Transmission><Vaccination><Vaccination acquired immunity><Vaccination induced immunity><Vaccines><Work><accumulated exposure><accumulated long-term exposure><acquired immunity><aggregate exposure><antibody biosynthesis><arm><attenuate><attenuates><benchmark><blood corpuscles><cell mediated immune response><circumsporozoite protein><cohort><cs protein><cumulative exposure><cumulative life exposure><cumulative long-term exposure><develop a vaccine><develop vaccines><development of a vaccine><experiment><experimental research><experimental study><experiments><febrile><febris><flow cytophotometry><hepatic body system><hepatic organ system><high dimensionality><host response><human model><immune activation><immune system response><immunogen><immunoglobulin biosynthesis><immunoresponse><improved><induced Cre><inducible Cre><insight><kids><life-course exposure><lifelong exposure><lifespan exposure><lifetime exposure><liver macrophage><memory CD4 T cell><memory CD4 T lymphocyte><model of human><mouse model><murine model><novel><prevent><preventing><prospective research study><prospective survey><response><rodent plasmodia><social role><totality of exposures><transcription factor><transcriptomics><transmission process><vaccine acquired immunity><vaccine associated immunity><vaccine candidate><vaccine development><vaccine efficacy><vaccine response><vaccine responsiveness><vaccine-induced immunity><vaccine-induced protection><vaccine-induced response><vaccines against malaria><youngster>
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Alexandra Felicia Muratore

NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NEW YORK, NY

Exploratory lead · 16/100
Active award
$202,585
FY 2026

Project Title

Neural predictors of outcome during relapse prevention treatment for anorexia nervosa

Grant Number:

5R21MH132085-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2027

Project Abstract

Anorexia nervosa (AN) is a devastating psychiatric illness with significant morbidity and mortality rates, and relapse rates ranging from 40-80% after acute treatment. Extreme restriction of food intake is the central behavioral disturbance in illness, and confers significantly greater risk for rela...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Acute><Address><Adult><Adult Human><Advanced Development><Aged 65 and Over><Anorexia Nervosa><Architecture><Area><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biological Markers><Body Weight decreased><Characteristics><Clinical><Clinical Trials><Cognition Therapy><Cognitive><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Conditioning Therapy><Corpus Striatum><Corpus striatum structure><Data><Death Rate><Development><Dorsal><Eating><Eating Behavior><Engineering / Architecture><Fear><Food Intake><Food Preferences><Foundations><Fright><Functional MRI><Functional Magnetic Resonance Imaging><Funding Mechanisms><Goals><Habits><Heterogeneity><Hospital Admission><Hospitalization><Hospitals><Incentives><Individual><Individual Differences><Inpatients><Intervention><Knowledge><Learning><Mediating><Mental disorders><Mental health disorders><Modeling><Morbidity><Morbidity - disease rate><NIMH><National Institute of Mental Health><Neurobiology><Obsessive-Compulsive Disorder><Obsessive-Compulsive Neurosis><Outcome><Patients><Pattern><Population><Prediction of Response to Therapy><Preventative strategy><Prevention program><Prevention strategy><Preventive strategy><Proxy><Psychiatric Disease><Psychiatric Disorder><Psychiatry><Randomized><Recovery><Relapse><Research><Resistance><Rest><Rewards><Role><Scanning><Science><Strategic Planning><Striate Body><Striatum><System><Testing><Treatment outcome><Variant><Variation><Weight><Weight Loss><Weight Reduction><Work><above age 65><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><behavior intervention><behavioral intervention><bio-markers><biologic marker><biomarker><biomarker development><body weight loss><brain based><clinical development><clinical predictors><clinical relevance><clinically relevant><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cognitive control><design><designing><developmental><diet choice><diet preference><dietary choice><dietary preferences><fMRI><fMRI scan><food choice><food restriction><functional MRI scan><functional magnetic resonance imaging scan><human old age (65+)><improved><maladaptive behavior><mental illness><morbidity rate><mortality><mortality rate><neural><neural circuit><neural circuitry><neural imaging><neural patterning><neuro-imaging><neurobiological><neurocircuitry><neuroimaging><neurological imaging><neuropathologic><neuropathological><neuropathology><novel><outcome prediction><over 65 years><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><predict responsiveness><predict therapeutic response><predict therapy response><predicting response><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prevent relapse><prevention clinical trial><programs><psychiatric illness><psychological disorder><randomisation><randomization><randomly assigned><rate of change><relapse prediction><relapse prevention><relapse risk><repetitive behavior><resistant><response><response to therapy><response to treatment><restrictive eating><social role><striatal><synaptic circuit><synaptic circuitry><therapeutic response><therapy prediction><therapy response><treatment prediction><treatment program><treatment response><treatment response prediction><treatment responsiveness><trial comparing><weight restoration><weights><wt-loss><≥65 years>
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JOANNA E STEINGLASS

NEW YORK STATE PSYCHIATRIC INSTITUTE DBA RESEARCH FOUNDATION FOR MENTAL HYGIENE, INC, NEW YORK, NY

Exploratory lead · 16/100
Active award
$202,585
FY 2026

Project Title

Neural predictors of outcome during relapse prevention treatment for anorexia nervosa

Grant Number:

5R21MH132085-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2027

Project Abstract

Anorexia nervosa (AN) is a devastating psychiatric illness with significant morbidity and mortality rates, and relapse rates ranging from 40-80% after acute treatment. Extreme restriction of food intake is the central behavioral disturbance in illness, and confers significantly greater risk for rela...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><Acute><Address><Adult><Adult Human><Advanced Development><Aged 65 and Over><Anorexia Nervosa><Architecture><Area><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biological Markers><Body Weight decreased><Characteristics><Clinical><Clinical Trials><Cognition Therapy><Cognitive><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Conditioning Therapy><Corpus Striatum><Corpus striatum structure><Data><Death Rate><Development><Dorsal><Eating><Eating Behavior><Engineering / Architecture><Fear><Food Intake><Food Preferences><Foundations><Fright><Functional MRI><Functional Magnetic Resonance Imaging><Funding Mechanisms><Goals><Habits><Heterogeneity><Hospital Admission><Hospitalization><Hospitals><Incentives><Individual><Individual Differences><Inpatients><Intervention><Knowledge><Learning><Mediating><Mental disorders><Mental health disorders><Modeling><Morbidity><Morbidity - disease rate><NIMH><National Institute of Mental Health><Neurobiology><Obsessive-Compulsive Disorder><Obsessive-Compulsive Neurosis><Outcome><Patients><Pattern><Population><Prediction of Response to Therapy><Preventative strategy><Prevention program><Prevention strategy><Preventive strategy><Proxy><Psychiatric Disease><Psychiatric Disorder><Psychiatry><Randomized><Recovery><Relapse><Research><Resistance><Rest><Rewards><Role><Scanning><Science><Strategic Planning><Striate Body><Striatum><System><Testing><Treatment outcome><Variant><Variation><Weight><Weight Loss><Weight Reduction><Work><above age 65><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><behavior intervention><behavioral intervention><bio-markers><biologic marker><biomarker><biomarker development><body weight loss><brain based><clinical development><clinical predictors><clinical relevance><clinically relevant><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cognitive control><design><designing><developmental><diet choice><diet preference><dietary choice><dietary preferences><fMRI><fMRI scan><food choice><food restriction><functional MRI scan><functional magnetic resonance imaging scan><human old age (65+)><improved><maladaptive behavior><mental illness><morbidity rate><mortality><mortality rate><neural><neural circuit><neural circuitry><neural imaging><neural patterning><neuro-imaging><neurobiological><neurocircuitry><neuroimaging><neurological imaging><neuropathologic><neuropathological><neuropathology><novel><outcome prediction><over 65 years><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><predict responsiveness><predict therapeutic response><predict therapy response><predicting response><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prevent relapse><prevention clinical trial><programs><psychiatric illness><psychological disorder><randomisation><randomization><randomly assigned><rate of change><relapse prediction><relapse prevention><relapse risk><repetitive behavior><resistant><response><response to therapy><response to treatment><restrictive eating><social role><striatal><synaptic circuit><synaptic circuitry><therapeutic response><therapy prediction><therapy response><treatment prediction><treatment program><treatment response><treatment response prediction><treatment responsiveness><trial comparing><weight restoration><weights><wt-loss><≥65 years>
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Kazlin Mason

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Exploratory lead · 16/100
Active award
$201,875
FY 2026

Project Title

Development of an MRI Guided Machine Learning Algorithm to Assess the Velopharyngeal Mechanism

Grant Number:

5R21DC021023-03

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2026

Project Abstract

PROJECT SUMMARY More than 25-35% of children with velopharyngeal (VP) or palatal anomalies, such as those associated with repaired cleft palate and/or craniofacial conditions, will develop velopharyngeal dysfunction (VPD) as evidenced by hypernasal speech. This can negatively impact quality of life...

Research Terms

<0-11 years old><3-D><3-Dimensional><3D><4 year old><4 years of age><AI Augmented><AI assisted><AI driven><AI enhanced><AI integrated><AI powered><AI system><Acceleration><Air><Algorithms><Anatomic Sites><Anatomic structures><Anatomy><Area><Artificial Intelligence><Artificial Intelligence enhanced><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Biomedical Engineering><Body Tissues><Bone Tissue><Causality><Child><Child Health><Child Youth><Childhood><Children (0-21)><Cleft Palate><Clinical><Clinical assessments><Collaborations><Communication><Computational Geometry><Computational toolkit><Computer Reasoning><ConvNet><Craniofacial Abnormalities><Data><Data Science><Data Set><Decision Making><Development><Disease><Disorder><Dysfunction><Etiology><Evaluation><Face><Failure><Fostering><Foundations><Friends><Functional disorder><Future><Goals><Investigation><Live Birth><MR Imaging><MR Tomography><MRI><MRIs><Machine Intelligence><Machine Learning><Magnetic Resonance Imaging><Manuals><Measurement><Mechanics><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Methodology><Methods><Mission><Morphology><Muscle><Muscle Tissue><NIDCD><NMR Imaging><NMR Tomography><Nasal><Nasal Passages Nose><National Institute on Deafness and Other Communication Disorders><Nose><Nuclear Magnetic Resonance Imaging><Operative Procedures><Operative Surgical Procedures><Oral><Outcome><Patients><Physiology><Physiopathology><Plastic Surgical Procedures><Procedures><Process><Process Assessment><QOL><Quality of life><Recommendation><Reporting><Research><Respiratory System, Nose, Nasal Passages><Sample Size><Second Look><Second Look Surgery><Severities><Site><Speech><Strategic Planning><Structure><Surgical><Surgical Interventions><Surgical Management><Surgical Procedure><Surgical Revision><Technology><Testing><Time><Tissues><Training><Translational Research><Translational Science><Variant><Variation><Work><Zeugmatography><age 4><age 4 years><analytical method><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><automated algorithm><automated analysis><automatic algorithm><bio-engineered><bio-engineers><bioengineering><biological engineering><care burden><causation><clinical care><clinical decision-making><clinical development><clinical practice><clinical translation><clinically translatable><computational toolbox><computational tools><computational toolset><computerized tools><convolutional network><convolutional neural nets><convolutional neural network><craniofacial><craniofacial anomalies><craniofacial defects><craniofacial malformation><craniofacies><deep learning><deep learning algorithm><deep learning method><deep learning strategy><developmental><disease causation><early childhood><enhanced with AI><enhanced with Artificial Intelligence><faces><facial><four year old><four years of age><improved><innovate><innovation><innovative><interest><kids><large data sets><large datasets><large scale data><large scale data sets><large scale datasets><life span><lifespan><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><mechanic><mechanical><muscular><novel><operation><operations><pathophysiology><patient population><pediatric><plastic surgery><precision medicine><precision-based medicine><prospective><repair><repaired><soft tissue><success><surgery><surgery outcome><surgical outcome><three dimensional><tool><tool development><translation research><translational applications><translational investigation><youngster>
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Elena Jean Tenenbaum

DUKE UNIVERSITY, DURHAM, NC

Exploratory lead · 16/100
Active award
$201,250
FY 2026

Project Title

Examining precursors to language impairment in ASD via remote assessment

Grant Number:

5R21DC022378-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2027

Project Abstract

Project Summary/Abstract Roughly 30% of autistic individuals remain minimally verbal as adults, often despite significant intervention. This is due, in part, to our limited understanding of the mechanisms underlying language development in autistic children. This gap in our knowledge is attributable...

Research Terms

<0-11 years old><21+ years old><3 year old><3 years of age><ASD><Acoustics><Adult><Adult Human><Autism><Autism Diagnosis><Autistic Disorder><Behavior><Child><Child Youth><Children (0-21)><Clinical><Code><Coding System><Cognitive><Computer Vision Systems><Computer software><Computers><Data><Development><Diagnosis><Early Diagnosis><Early Infantile Autism><Enrollment><Evidence based intervention><Family><Future><Goals><Grant><Heterogeneity><Home><Impairment><Individual><Infant><Infantile Autism><Intervention><Investigation><Investigators><Kanner's Syndrome><Knowledge><Laboratories><Language><Language Development><Language Disorders><Learning><Link><Measures><NIDCD><National Institute on Deafness and Other Communication Disorders><Outcome><Parents><Pattern><Performance><Persons><Population><Process><Prospective Studies><Psychologist><QOL><QOL improvement><Quality of life><Reporting><Research><Research Personnel><Researchers><Sample Size><Sampling><Services><Siblings><Software><Speech><Speech Perception><Speech Sound><Testing><Time><Training><Visit><Work><acquiring language skills><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age 3><age 3 years><autism spectral disorder><autism spectrum disorder><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><career><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical diagnosis><cognitive ability><cognitive development><cognitive task><computer vision><design><designing><developmental><early detection><enroll><experiment><experimental research><experimental study><experiments><gaze><homes><improved><improvements in QOL><improvements in quality of life><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><infancy><infantile><kids><language ability><language acquisition><language deficit><language impairment><language learning><language onset><language outcome><language skills><minimally speaking><minimally verbal><parent><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><precision medicine><precision-based medicine><prospective research study><prospective survey><quality of life improvement><remote administration><remote assessment><remote evaluation><response><skills><sound><speech processing><success><three year old><three years of age><youngster>
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Wenjun Deng

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 16/100
Active award
$200,400
FY 2026

Project Title

Red Blood Cell BPGM Deficiency Contributes to Cognitive Impairment Following Ischemic Stroke

Grant Number:

5R21NS140800-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

Project Summary/Abstract Cognitive impairment (CI) affects up to 60% of stroke survivors, significantly impacting morbidity and mortality after stroke. Understanding the mechanisms underlying CI following stroke is crucial for early diagnosis and interventions, potentially slowing or preventing the ...

Research Terms

<Abeta synthesis><Abnormal Erythrocytes><Abnormal Red Blood Cell><Affect><Affinity><Alzheimer beta-Protein><Alzheimer's Amyloid beta-Protein><Alzheimer's amyloid><Amentia><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β production><Amyloid β synthesis><Amyloid β-Peptide><Amyloid β-Protein><Animals><Apoplexy><Aβ><Aβ production><Aβ synthesis><Binding><Biology><Blood - brain barrier anatomy><Blood Vessels><Blood erythrocyte><Blood-Brain Barrier><Body Tissues><Brain><Brain Nervous System><Brain Vascular><Brain Vascular Accident><Cell Body><Cell Function><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cerebrovascular system><Cessation of life><Clinical><Clinical Research><Clinical Study><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive deficits><Cognitive function abnormal><Complex><Comprehension><Data><Death><Dementia><Development><Disturbance in cognition><Early Diagnosis><Early Intervention><Early treatment><Encephalon><Ensure><Enzyme Gene><Enzymes><Erythrocytes><Erythrocytic><Event><Exhibits><Foundations><Goals><Grant><HIF 1><HIF-1 protein><HIF1><HIF1 protein><Hemato-Encephalic Barrier><Hemoglobin><Hypoxia><Hypoxic><Impaired cognition><Individual><Intermediary Metabolism><Intervention><Intramolecular Transferases><Investigation><Ischemic Stroke><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Light><Marrow erythrocyte><Mediating><Metabolic Pathway><Metabolic Processes><Metabolism><Modeling><Molecular><Molecular Interaction><Morbidity><Mutase><Neurovascular dysfunction><Null Mouse><O element><O2 element><Outcome><Oxygen><Oxygen Deficiency><Pathway interactions><Patients><Photoradiation><Pilot Projects><Play><Process><Production><QOL><Quality of life><Red Blood Cells><Red Cell><Research><Risk><Risk Factors><Role><Severities><Stroke><Subcellular Process><Therapeutic><Therapeutic Intervention><Tissues><Vascular Diseases><Vascular Disorder><Vascular System><Wild Type Mouse><a beta peptide><abeta><abeta accumulation><abeta aggregation><abeta production><after stroke><amyloid beta><amyloid beta accumulation><amyloid beta aggregation><amyloid beta production><amyloid beta synthesis><amyloid β accumulation><amyloid β aggregation><amyloid-b protein><aβ accumulation><aβ aggregation><beta amyloid fibril><blood corpuscles><blood vessel disorder><blood vessels in the brain><bloodbrain barrier><brain attack><brain blood vessels><brain vasculature><cardiac disease induced cognitive impairment><cerebral blood vessel><cerebral vascular><cerebral vascular accident><cerebral vasculature><cerebro-vascular><cerebrovascular><cerebrovascular accident><cerebrovascular contribution to cognitive impairment and dementia><cerebrovascular vessels><cerebrovasculature><clinical applicability><clinical application><clinical relevance><clinically relevant><cognitive decline after stroke><cognitive decline in stroke><cognitive defects><cognitive dysfunction><cognitive dysfunction after stroke><cognitive dysfunction in stroke><cognitive function><cognitive function after stroke><cognitive impairment after stroke><cognitive impairment in stroke><cognitive loss><cognitive outcome after stroke><cognitive outcome from stroke><cognitive outcome of stroke><cohort><developmental><disability><early detection><early therapy><experience><health care burden><hypoxia inducible factor 1><improved><in vivo><innovate><innovation><innovative><insight><intervention therapy><mortality><mouse model><murine model><neuro-vascular><neurovascular><neurovascular abnormality><neurovascular dysregulation><neurovascular impairment><neurovascular pathology><neurovasculopathy><novel><pathway><pilot study><post stroke><post stroke cognitive decline><post stroke cognitive dysfunction><post stroke cognitive function><post stroke cognitive impairment><post-stroke cognitive outcome><poststroke><poststroke cognitive decline><poststroke cognitive dysfunction><poststroke cognitive impairment><prevent><preventing><response><slow potential><social role><soluble amyloid precursor protein><stroke cognitive outcome><stroke patient><stroke survivor><stroked><strokes><vascular><vascular cognitive impairment and dementia><vascular contribution to impairment or dementia><vascular contributions to cognition/dementia><vascular contributions to cognitive decline and dementia><vascular contributions to cognitive impairment and dementia><vascular dysfunction><vasculopathy><wildtype mouse>
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Jeffrey Scott Smith

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Exploratory lead · 16/100
Active award
$196,543
FY 2026

Project Title

3-hydroxybutyrate: an unexpected longevity factor in yeast

Grant Number:

5R21AG092022-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

Abstract Saccharomyces cerevisiae (budding yeast) has played a key role in identifying and characterizing multiple longevity factors and healthspan/lifespan interventions such as caloric restriction (CR), methionine restriction (MetR) and rapamycin (TOR inhibition) but has been absent from the eluc...

Research Terms

<3 Hydroxybutyrate><3-hydroxy-3-methylglutaryl-CoA><3-hydroxy-3-methylglutaryl-coenzyme A><Acetoacetates><Acetyl CoA><Acetyl Coenzyme A><Acyl-CoA-Transferases><Age related pathologies><Aging><Assay><Baker's Yeast><Bioassay><Biochemical><Biologic Models><Biological Assay><Biological Models><Blood Circulation><Bloodstream><Brain><Brain Nervous System><Brewer's Yeast><Budding Yeast><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Caloric Restriction><Cancers><Carbohydrates><Cardiovascular Diseases><Catabolism><Cell Aging><Cell Body><Cell Cycle><Cell Division Cycle><Cell Senescence><Cells><Cellular Aging><Cellular Senescence><Chronology><CoA><CoA-Transferases><Coenzyme A><Coenzyme A-Transferases><Culture Media><D-Glucose><Dehydrogenases><Development><Dextrose><Drosophila><Drosophila genus><Encephalon><Endomycetales><Enzyme Gene><Enzymes><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Eukaryota><Eukaryote><Exclusion><Fasting><Future><Gene Transcription><Generalized Growth><Genetic><Genetic Transcription><Glucose><Goals><Growth><HMG-CoA><Health Benefit><Heart><Hepatic><Increase lifespan><Intervention><Ketone Bodies><Ketosis><L-Lysine><Length of Life><Link><Liver><Longevity><Lyase><Lyase Gene><Lysine><Malignant Neoplasms><Malignant Tumor><Mammalia><Mammals><Mediator><Metabolic Pathway><Methionine><Methods><Mice><Mice Mammals><Mitochondria><Model System><Modeling><Murine><Mus><Nematoda><Nematodes><Nerve Degeneration><Neuron Degeneration><Nutrient><Organ><Organism><Ortholog><Orthologous Gene><Oxidoreductase><Oxidoreductase Gene><Pathogenicity><Pathway interactions><Peripheral><Phase><Phenotype><Physiologic><Physiological><Play><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Production><Protein Modification><Proteins><Proteomics><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Expression><Rapamune><Rapamycin><Reductases><Regimen><Regulation><Replicative Senescence><Reporting><Research Grants><Research Project Grants><Research Projects><Role><S cerevisiae><S-acetate Coenzyme A><S. cerevisiae><Saccharomyces cerevisiae><Saccharomycetales><Sirolimus><Starvation><Supplementation><System><Tissue Growth><Transcription><Validation><Yeasts><age associated pathologies><age dependent pathologies><age induced pathologies><aging associated><aging associated pathologies><aging dependent pathologies><aging induced pathologies><aging pathologies><aging related><aging related pathologies><beta-Hydroxybutyrate><boost longevity><calorie restriction><candidate validation><cardiovascular disorder><developmental><dietary><elongating the lifespan><enhance healthspan><enhance longevity><epigenetically><experiment><experimental research><experimental study><experiments><extend healthspan><extend life span><extend lifespan><extend longevity><extending healthy lifespan><fasted><fasts><foster longevity><fruit fly><genome wide screen><growth media><healthspan><healthspan extension><healthy life span><hepatic body system><hepatic organ system><hydroxymethylglutaryl-CoA><improve healthspan><improve lifespan><improve longevity><increase healthspan><interest><intervention enhancing longevity><intervention to extend lifespan><intervention to improve lifespan><intervention to increase longevity><intervention to prolong lifespan><intervention to promote longevity><keto diet><ketogenesis><ketogenic diet><life span><lifespan><lifespan extending intervention><lifespan extending therapies><lifespan extension><lifespan improving intervention><lifespan increasing intervention><lifespan increasing therapies><lifespan intervention><lifespan prolonging interventions><lifespan promoting intervention><living system><longevity boosting intervention><longevity extending intervention><longevity intervention><longevity promoting intervention><longevity therapy><longevity treatment><malignancy><metabolism measurement><metabolomics><metabonomics><mitochondrial><neoplasm/cancer><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal degeneration><novel><ontogeny><pathway><postmitotic><prolong healthspan><prolong lifespan><prolong longevity><promote healthspan><promote lifespan><promote longevity><replicative aging><response><roundworm><social role><strategy to enhance longevity><strategy to promote longevity><support longevity><tool><validations><β-Hydroxybutyrate>
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Jason Heikenfeld

UNIVERSITY OF CINCINNATI, CINCINNATI, OH

Exploratory lead · 16/100
Active award
$191,337
FY 2026

Project Title

Aptamer tagging with redox quenchers: a critical breakthrough in the sensitivity of continuous electrochemical protein monitoring

Grant Number:

5R21EB036615-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

Project Summary The impact of continuous molecular monitoring has now been clearly demonstrated by continuous glucose monitors, a mature technology that costs merely $25 to manufacture a fully-disposable 2 week device. Attempting to build upon glucose monitoring’s success, electrochemical aptamer se...

Research Terms

<Address><Albumins><Amino-terminal pro-brain natriuretic peptide><Animals><Assay><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Bioassay><Biological Assay><Blood><Blood Reticuloendothelial System><Blood capillaries><Cardiac><Chemical Warfare><Chemistry><Chronic Disease><Chronic Illness><Clinical><Common Rat Strains><Continuous Glucose Monitor><Development><Devices><Disease Management><Disorder Management><Drugs><Exclusion><Filtration><Filtration Fractionation><Goals><HPGF><Health Care><Hepatocyte-Stimulating Factor><Human><Humulin R><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immobilization><In vivo analysis><Insulin><Intercellular Fluid><Interleukin-6><Interstitial Fluids><Investigators><Knowledge><Leadership><Left><Length of Life><Letters><Longevity><MGI-2><Measures><Medication><Membrane><Modeling><Modern Man><Molecular><Monitor><Myeloid Differentiation-Inducing Protein><N-BNP peptide><N-terminal pro-BNP><NT-BNP><NT-proBNP><Needles><Novolin R><Outcome><Oxidation-Reduction><Peptides><Pharmaceutical Preparations><Physics><Physiologic><Physiological><Physiology><Plasmacytoma Growth Factor><Polymers><Proteins><Rat><Rats Mammals><Rattus><Redox><Regular Insulin><Research Personnel><Researchers><Skin><Surface><System><Techniques><Technology><Testing><Therapeutic><Time><Work><aptamer><capillary><chemical attack><chronic disorder><continuous blood glucose monitor><continuous blood sugar monitor><continuous glucose measurement><continuous monitoring><continuous sugar monitor><cost><developmental><drug/agent><experience><first in man><first-in-human><glucometer><glucose meter><glucose monitor><human data><improved><in vivo><in vivo evaluation><in vivo monitoring><in vivo testing><inflammation marker><inflammatory marker><innovate><innovation><innovative><interferon beta 2><manufacture><membrane structure><monolayer><orthopedic freezing><oxidation reduction reaction><polymer><polymeric><pro-brain natriuretic peptide (1-76)><proBNP(1-76)><response><sensing technology><sensor><sensor technology><sensor-based technology><small molecule><success><wearable><wearable device><wearable electronics><wearable health monitor><wearable health tracker><wearable monitor><wearable system><wearable technology><wearable tool><wearables>
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Lamba Omar Sangare

TEXAS A&M UNIVERSITY, COLLEGE STATION, TX

Exploratory lead · 16/100
Active award
$189,486
FY 2026

Project Title

Determining the mechanisms of Toxoplasma gondii colonization and crossing of the placental barrier

Grant Number:

5R21AI185518-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY Our understanding of Toxoplasma gondii (T. gondii) and other pathogens transmitted from mother to fetus is limited. However, they significantly contribute to fetal illness and death worldwide. This proposal aims to address this knowledge gap by identifying and characterizing T. gondi...

Research Terms

<0-11 years old><Address><Adhesion Molecule><Adhesions><Affect><Animal Model><Animal Models and Related Studies><Brain><Brain Nervous System><CD54 Antigens><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cas nuclease technology><Cavia><Cell Adhesion Molecule Gene><Cell Adhesion Molecules><Cell Body><Cell Surface Antigens><Cell fusion><Cell membrane><Cells><Cells Placenta-Tissue><Cessation of life><Child><Child Youth><Children (0-21)><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Congenital Toxoplasma Infections><Congenital Toxoplasma gondii Infection><Congenital Toxoplasmosis><Cytoplasmic Membrane><Data><Death><Defect><Development><ERK MAP Kinases><Encephalon><Environment><Epithelium><Extracellular Signal Regulated Kinases><Extracellular Signal-Regulated MAP Kinases><Fetus><Foundations><Future><GPI Membrane Anchors><GeneHomolog><Genes><Genetic><Glycoinositol Phospholipid Membrane Anchor><Glycosyl-Phosphatidylinositol Membrane Protein Anchors><Glycosylphosphatidylinositol Anchors><Goals><Guide RNA><Guinea Pigs><Guinea Pigs Mammals><High Throughput Assay><Homolog><Homologous Gene><Homologue><Human><ICAM-1><Immunological Surface Markers><In Vitro><Incidence><Infection><Ingestion><Integral Membrane Protein><Intercellular adhesion molecule 1><Intrinsic Membrane Protein><Investigators><Knock-out><Knockout><Knowledge><Libraries><MAPK ERK Kinases><Macrophage><Mediating><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Methods><Modern Man><Mothers><Mφ><Normal Placentoma><Parasites><Phosphorylation><Placenta><Placenta Embryonic Tissue><Placentome><Plasma Membrane><Pregnancy Complications><Process><Progenitor Cells><Protein Phosphorylation><Proteins><Recombinant Proteins><Recombinants><Research><Research Personnel><Researchers><Resistance><Role><Side><Structure><Surface><Surface Antigens><Surface Proteins><System><T gondii><T. gondii><Testing><Threonine/Tyrosine Protein Kinase><Time><Toxoplasma gondii><Transmembrane Protein><Transmembrane Protein Gene><Transmission><Upregulation><Vertical Transmission><Work><cell adhesion protein><complications during pregnancy><congenital infection><cytokine><design><designing><develop therapy><developmental><extracellular><extracellular signal related kinase><fetal><fetal infection><gRNA><guinea pig model><high throughput screening><in utero><in vivo><ingest><innovate><innovation><innovative><insight><intervention development><intestinal epithelium><kids><loss of function><malformation><migration><model of animal><mouse model><murine model><mutant><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathogen><plasmalemma><pregnancy-related complications><pregnant><prevent><preventing><resistant><secretory protein><social role><stem cells><therapy development><tool><transmission process><treatment development><trophoblast><trophoblast progenitor><trophoblast progenitor cell><trophoblast stem cell><youngster>
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Allison Mariko Okamura

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 16/100
Active award
$185,280
FY 2026

Project Title

Multipoint contact pressure for haptic sensory prostheses

Grant Number:

5R21EB036190-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY The human sense of touch plays a crucial role in our perceptual experiences and enabling motor tasks. Amputation, diabetes, stroke, and a host of other diseases result in loss of touch sensation, affecting modalities including vibration, skin deformation, proprioception, temperature,...

Research Terms

<3-D print><3-D printer><3D Print><3D printer><3D printing><Abscission><Address><Affect><Amputation><Apoplexy><Area><Auditory><Body Tissues><Body part><Brain Vascular Accident><Cell Communication and Signaling><Cell Signaling><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Communication><Cutaneous><Data><Data Set><Development><Devices><Diabetes Mellitus><Dimensions><Disease><Disorder><Dorsal><Drug Therapy><Elbow><Esthesia><Excision><Extirpation><Extremities><Feedback><Fingers><Forearm><Freedom><Gait><Goals><Home><Human><Hypesthesia><Hypoesthesia><Impaired Sensation><Individual><Intracellular Communication and Signaling><Ion Channel><Ionic Channels><Liberty><Light><Limb structure><Limbs><Location><Maps><Measures><Medical Rehabilitation><Membrane Channels><Methodology><Methods><Modality><Modern Man><Motor><Non-Trunk><Outcome><PNS Diseases><Pain><Painful><Participant><Pattern><Perception><Peripheral Nerve Diseases><Peripheral Nervous System Diseases><Peripheral Nervous System Disorders><Peripheral Neuropathy><Persons><Phalanx><Pharmacological Treatment><Pharmacotherapy><Photoradiation><Piezo 2><Piezo 2 ion channel><Piezo2><Play><Population><Position><Positioning Attribute><Proprioception><Prosthesis><Prosthetic device><Prosthetics><QOL improvement><Reduced Sensation><Rehabilitation><Rehabilitation therapy><Removal><Resolution><Role><Sensation><Sensory><Series><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Specific qualifier value><Specified><Stimulus><Stroke><Surgical Removal><Tactile Hypesthesia><Techniques><Temperature><Testing><Thumb><Thumb structure><Time><Tissues><Toes><Touch><Touch sensation><Visual><Work><Wrist><adult youth><arm><biological signal transduction><brain attack><cerebral vascular accident><cerebrovascular accident><developmental><diabetes><drug intervention><drug treatment><effectiveness measure><experience><haptic feedback><haptics><high risk><homes><improved><improvements in QOL><improvements in quality of life><indexing><life span><lifespan><loss of function><novel><older adult><older adulthood><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><portability><preservation><pressure><quality of life improvement><rehab therapy><rehabilitative><rehabilitative therapy><resection><resolutions><sensory prosthesis><sensory substitution><social role><stroked><strokes><tactile sensation><three dimensional printing><vibration><virtual><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><young adult><young adult age><young adulthood>
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Yusuke Shiozawa

WAKE FOREST UNIVERSITY HEALTH SCIENCES, WINSTON-SALEM, NC

Exploratory lead · 16/100
Active award
$177,131
FY 2026

Project Title

Contribution of cutaneous neuro-immune interactions to chemotherapy-induced peripheral neuropathy

Grant Number:

5R21CA297068-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

Project Summary While chemotherapy is the standard of care treatment for many cancer patients, a common side effect, chemotherapy-induced peripheral neuropathy (CIPN), is the leading cause of treatment discontinuation or dose reduction. This severe adverse event typically presents in the hands and f...

Research Terms

<1-OHP><Abnormal gait><Activities of Daily Living><Activities of everyday life><Acute><Affect><After Care><After-Treatment><Aftercare><Animal Model><Animal Models and Related Studies><BALB C Mouse><BALB/c><Behavior><CT-26><CT26><Cancer Patient><Cancers><Cell Body><Cell Communication><Cell Components><Cell Interaction><Cell Structure><Cell-to-Cell Interaction><Cells><Cellular Structures><Chemotherapy-induced peripheral neuropathy><Chronic><Clinic><Clinical Research><Clinical Study><Cutaneous><Data><Detectable Residual Disease><Development><Diagnostic Method><Diagnostic Procedure><Diagnostic Technique><Dorsal Root Ganglia><Dose><Esthesia><Foundations><Future><Gait abnormality><Gait disorder><Gait disturbances><Gait dysfunction><Gait impairment><Grant><Hand><Immune><Immunes><Immunity><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><In Vitro><Inbred BALB C Mice><Incidence><Infiltration><Inflammation><Langerhans cell><Loss of Sensation><Macrophage><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Marrow Mast Cell><Mediating><Mice><Mice Mammals><Minimal Residual Disease><Modeling><Murine><Mus><Mφ><Nerve><Nerve Cells><Nerve Fibers><Nerve Unit><Neural Cell><Neurocyte><Neuroimmune><Neurons><Numbness><Outcome><PNS Diseases><Pain><Painful><Pathogenesis><Patients><Peripheral><Peripheral Nerve Diseases><Peripheral Nervous System Diseases><Peripheral Nervous System Disorders><Peripheral Neuropathy><Play><Population><Predisposition><Proteomics><QOL><QOL improvement><Quality of life><RNA Seq><RNA sequencing><RNAseq><Recovery><Research><Residual Cancers><Residual Neoplasm><Residual Tumors><Role><Sampling><Sensation><Serious Adverse Event><Severe Adverse Event><Skin><Spinal Ganglia><Susceptibility><Symptoms><System><T-Cells><T-Lymphocyte><Testing><Time><Tissue Basophils><Walking impairment><afferent nerve><cancer cell><cell type><chemotherapeutic agent><chemotherapeutic compounds><chemotherapeutic drugs><chemotherapeutic medications><chemotherapy><clinical relevance><clinically relevant><colon cancer cell line><colorectal cancer cell line><daily living function><daily living functionality><density><developmental><dorsal root ganglion><experiment><experimental research><experimental study><experiments><foot><functional ability><functional capacity><gene signatures><genetic signature><hands><improved><improvements in QOL><improvements in quality of life><malignancy><mast cell><mastocyte><model of animal><mouse model><murine model><neglect><neoplasm/cancer><nerve damage><neuron toxicity><neuronal><neuronal toxicity><neuropathic pain><neurotoxicity><novel><oxaliplatin><oxaliplatine><pain sensation><painful neuropathy><painful sensation><post treatment><pre-clinical study><preclinical study><prevent><preventing><quality of life improvement><residual disease><scRNA sequencing><scRNA-seq><sensory nerve><serious adverse experience><serious adverse reaction><side effect><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><standard of care><subcutaneous><subdermal><survivorship><therapeutically effective><thymus derived lymphocyte><transcriptome sequencing><transcriptomic sequencing><tumor>
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Leala Holcomb

UNIVERSITY OF TENNESSEE KNOXVILLE, KNOXVILLE, TN

Exploratory lead · 16/100
Active award
$157,500
FY 2026

Project Title

Strategic and Interactive Signing Instruction (SISI): An intervention program to support sign language development in deaf children

Grant Number:

5R21DC021024-03

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2026

Project Abstract

Project Summary Deaf children who reach the age of eight without a foundation in language have longitudinal struggles in the areas of receptive and expressive language, working memory, executive functions, literacy and academic skills, and behavioral, mental, social, and physical health. The lack of...

Research Terms

<0-11 years old><5 year old><5 years of age><8 year old><8 years of age><Academic skills><Acceleration><Address><Age><Area><Articulation><Behavioral><Characteristics><Child><Child Youth><Children (0-21)><Cognitive><Communication><Competence><Complex><Data><Data Collection><Development><Dose><Education for Intervention><Educational Intervention><Exploratory/Developmental Grant for Diagnostic Cancer Imaging><Family><Foundations><Friends><Future><Goals><Health><Immediate Memory><Individual><Instruction><Instruction Intervention><Intervention><Knowledge><Language><Language Delays><Language Development><Linguistic><Linguistics><Literature><Manuals><Modification><Monitor><NIDCD><National Institute on Deafness and Other Communication Disorders><Oral><Outcome><Population><Preparation><Process><Protocol><Protocols documentation><Psyche structure><R21 Award><Randomized, Controlled Trials><Reporting><Research><Research Design><Sampling><Short-Term Memory><Sign Language><Standardization><Study Type><Training><Training Intervention><Work><Writing><acquiring language skills><age 5><age 5 years><age 8><age 8 years><ages><career><clinical applicability><clinical application><cognitive function><critical period><deaf><deafened><design><designing><determine efficacy><developmental><disability><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><efficacy testing><eight year old><eight years of age><evaluate efficacy><evidence base><examine efficacy><executive control><executive function><experiment><experimental research><experimental study><experiments><five year old><five years of age><high risk><implementation protocol><improved><innovate><innovation><innovative><instructional intervention><intervention design><intervention program><iterative design><kids><language ability><language acquisition><language learning><language skills><literacy><meeting><meetings><mental><physical conditioning><physical health><post intervention><preparations><prevent><preventing><profound hearing loss><randomized control trial><remediation><response><scaffold><scaffolding><skills><social><social culture><socio-cultural><sociocultural><study design><teacher><theories><therapy design><treatment design><working memory><youngster>
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Juliet Gopinath

UNIVERSITY OF COLORADO, Boulder, CO

Exploratory lead · 16/100
Active award
$148,319
FY 2026

Project Title

Low-voltage liquid lens enabled endoscopic optical coherence tomography

Grant Number:

5R21EB037238-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/10/2025

End Date:

12/31/2027

Project Abstract

Project Summary This is an application in response to FOA number, PAR-24-022 (NIBIB), “Trailblazer Award for New and Early Stage Investigators (R21 Clinical Trial Optional)”. Recently, we demonstrated non-mechanical scanning for imaging. This technology can be used for a miniature forward-viewing en...

Research Terms

<3-D Imaging><3-D print><3-D printer><3D Print><3D imaging><3D printer><3D printing><Award><Biopsy><Cancers><Cardiology><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Clinical Trials><Compensation><Computer software><Coupled><Custom><Device Designs><Devices><Diameter><Dimensions><Doppler OCT><Electrostatics><Elements><Endoscopes><Engineering><Fiber><Fibrosis><Geometry><Goals><Heart Vascular><Human><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Investigators><Laser Electromagnetic><Laser Radiation><Lasers><Lateral><Length><Letters><Light><Liquid substance><Malignant Neoplasms><Malignant Tumor><Mechanics><Meniscus><Meniscus structure of joint><Methods><Microscopy><Miniaturisations><Miniaturization><Modeling><Modern Man><Monitor><NIBIB><National Institute of Biomedical Imaging and Bioengineering><Nature><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><OCT Tomography><Operative Procedures><Operative Surgical Procedures><Optical Coherence Tomography><Optics><Performance><Photoradiation><Price><RF ablation><Radio Frequency Ablation><Radiofrequency Ablation><Radiofrequency Interstitial Ablation><Research><Research Personnel><Researchers><Resistance><Resolution><Sampling><Scanning><Shapes><Software><Source><Speed><Surgical><Surgical Interventions><Surgical Procedure><System><Technology><Testing><Thick><Thickness><Three-Dimensional Imaging><Tissue Sample><Tissue imaging><Variant><Variation><Weight><Work><adaptive optics><cardiac imaging><cardiac scanning><cardiovascular disorder><cardiovascular imaging><circulatory system><clinical diagnostics><customs><design><designing><electric field><fluid><heart imaging><heart scanning><high resolution imaging><imaging><imaging in vivo><improved><in vivo><in vivo imaging><innovate><innovation><innovative><insight><lens><lenses><light weight><lightweight><liquid><malignancy><mechanic><mechanical><medical diagnostic><meter><miniaturize><miniaturized><neoplasm/cancer><neurological disease><novel><operation><operations><optical><optical Doppler tomography><optical coherence Doppler tomography><point of care><power consumption><pricing><prototype><resistant><resolutions><response><surgery><three dimensional printing><tissue phantom><voltage><weights>
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Raquel Hontecillas

NIMML INSTITUTE, INC., Blacksburg, VA

Exploratory lead · 16/100
Active award
$147,125
FY 2026

Project Title

Immunometabolic Mechanisms of Protection against Infection

Grant Number:

5R21AI182927-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

Immunometabolic Mechanisms of Protection against Infection The NIMML Institute is a 501 (c) (3) non-profit public foundation focused on a transdisciplinary, team-science approach to precision medicine at the interface of immunology, inflammation, and metabolism. We are pioneering fundamental researc...

Research Terms

<3'5'-cyclic ester of AMP><3,5 cyclic AMP synthetase><3-10C><AMCF-I><Acetyl CoA><Acetyl Coenzyme A><Acute><Adenosine Cyclic 3',5'-Monophosphate><Adenosine Cyclic Monophosphate><Adenosine Cyclic Monophosphate-Dependent Protein Kinases><Adenosine, cyclic 3',5'-(hydrogen phosphate)><Adenyl Cyclase><Adenylate Cyclase><Adenylyl Cyclase><Affect><Agonist><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Apoptosis><Apoptosis Pathway><Applications Grants><Autoimmune Diseases><Bacteria><Bacterial Toxins><Bacterial Translocation><C diff><C difficile><C. diff><C. difficile><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><CXCL8><Cas nuclease technology><Cell Body><Cell Communication and Signaling><Cell Death><Cell Signaling><Cell Survival><Cell Viability><Cells><Cellular injury><Cessation of life><Clinical><Clostridioides difficile><Clostridium difficile><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Colon><Colonic inflammation><Communicable Diseases><Cyclic AMP><Cyclic AMP-Dependent Protein Kinases><Cytosol><Data><Death><Development><Diagnosis><Endocytosis><Endosomes><Environment><Epithelial Cells><Epithelium><Event><Exposure to><Family><Foundations><GCP1><GI colonization><GI microbiome><Genes><Glycolysis><Gram-Positive Bacteria><Grant Proposals><H(+) Pump><H+ Pump><Human><IL-8><IL8><IL8 gene><Immune response><Immunity><Immunology><Immunomodulation><Impairment><In Vitro><Infection><Infection-induced colitis><Infectious Diseases><Infectious Disorder><Infectious colitis><Inflammasome><Inflammation><Intercept><Intermediary Metabolism><Intervention><Intestinal><Intestines><Intoxication><Intracellular Communication and Signaling><Intracellular Transport><K60><Ligase><Ligase Gene><Link><Metabolic><Metabolic Processes><Metabolism><Miscellaneous Antibiotic><Mitochondria><Modern Man><Molecular><Molecular Target><Organoids><Outcome><PKA><PKA inhibitor><Pathogenicity Factors><Pathway interactions><Permeability><Persons><Phylogenetic Analysis><Phylogenetics><Programmed Cell Death><Protein Family><Protein Kinase A><Proteins><Proton Pump><Pyruvate><Receptosomes><Recovery><Recurrence><Recurrent><Reproduction spores><Role><S-acetate Coenzyme A><SCYB8><Science><Severity of illness><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Spores><Synthetases><TSG-1><Therapeutic><Toxin><Treatment Efficacy><Treatment outcome><V-ATPase><V-type ATPase><Variant><Variation><Virulence Factors><adenosine 3'5' monophosphate><anti-microbial><antimicrobial><autoimmune condition><autoimmune disorder><autoimmunity disease><b-ENAP><bacterial disease treatment><bacterial infectious disease treatment><biological signal transduction><bowel><cAMP><cAMP-Dependent Protein Kinases><cell damage><cell injury><cellular damage><damage to cells><developmental><digestive tract microbiome><disease control><disease severity><disorder control><enteric microbiome><experiment><experimental research><experimental study><experiments><fundamental research><gastrointestinal microbiome><gastrointestinal tract colonization><glucose metabolism><gut colonization><gut microbiome><gut-associated microbiome><host response><immune modulation><immune regulation><immune system response><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresponse><inflamed colon><injury to cells><insight><intervention efficacy><intestinal biome><intestinal colonization><intestinal epithelium><intestinal microbiome><lanthionine><mitochondrial><necrocytosis><novel><pathway><pharmacologic><precision medicine><precision-based medicine><prevent><preventing><receptor mediated endocytosis><response><rho><rho G-Proteins><rho GTP-Binding Proteins><rho GTPases><rho Protein P21><rho Small GTP-Binding Proteins><social role><societal costs><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic efficacy><therapeutically effective><therapy efficacy><vacuolar ATPase><vacuolar H+-ATPase><vacuolar membrane H(+)-ATPase>
View Full Project Details on NIH Reporter
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Oscar Vazquez Mena

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 16/100
Active award
$144,810
FY 2026

Project Title

Subwavelength ultrasound focusing using negative index refraction metamaterials

Grant Number:

5R21EB036218-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/16/2025

End Date:

1/31/2028

Project Abstract

SUMMARY/ABSTRACT Ultrasound is one of the most versatile tools in medicine for non-invasive imaging and therapies. As with any wave phenomenon, one of the limitations in ultrasound resolution is the diffraction limit. In this project, we propose the use of negative-index non-resonant acoustic metama...

Research Terms

<3-D><3-Dimensional><3D><Acoustics><Architecture><Behavior><Cephalic><Ceramics><Compensation><Cranial><Dimensions><Echography><Echotomography><Electrical Impedance><Engineering / Architecture><Focused Ultrasound><Frequencies><Future><Hydrogen Oxide><Image><Impedance><Lateral><Liquid substance><Mechanics><Medical Ultrasound><Medicine><Membrane><Methods><Outcome><Phase><Physiologic pulse><Position><Positioning Attribute><Process><Property><Pulse><Refractive Indices><Research><Resolution><Route><Si element><Silicon><Skull><Solid><Source><System><Technology><Therapeutic><Thick><Thickness><Transmission><Ultrasonic Imaging><Ultrasonogram><Ultrasonography><Ultrasound Diagnosis><Ultrasound Medical Imaging><Ultrasound Test><Variant><Variation><Water><Work><acoustic imaging><active control><chemical stability><cranium><diagnostic ultrasound><electric impedance><fabrication><fabrication technology><fluid><imaging><improved><indexing><innovate><innovation><innovative><lens><lenses><liquid><manufacture><manufacturing technology><mechanic><mechanical><mechanical properties><membrane structure><meter><non-invasive diagnosis><non-invasive diagnostic><non-invasive imaging><noninvasive diagnosis><noninvasive diagnostic><noninvasive imaging><novel><operation><operations><prevent><preventing><resolutions><sonogram><sonography><sound measurement><success><three dimensional><tool><transmission process><ultrasound><ultrasound imaging><ultrasound scanning><waveguide>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Marius George Linguraru

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 16/100
Active award
$78,869
FY 2026

Project Title

Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings

Grant Number:

3R33HD102988-04S1

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

SUMMARY Congenital anomalies represent an increasing burden of disease worldwide, accounting for millions of birth defect-related disabilities with a disproportionate impact on Low to Middle Income Countries (LIMCs). Many harbor genetic etiologies, for which no confirmatory diagnosis can be made due...

Research Terms

<0-11 years old><0-4 weeks old><AI Augmented><AI assisted><AI based><AI driven><AI enhanced><AI integrated><AI model training><AI powered><AI system><AI technology><AI training><Accounting><Active Follow-up><Address><Affect><Android App><Android Application><Aneuploid><Aneuploidy><Appearance><Artificial Intelligence><Artificial Intelligence enhanced><Artificial intelligence model training><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Belgian Congo><Biometrics><Biometry><Biostatistics><Birth Defects><Birth Rate><Bucca><Capillary Electrophoresis><Capillary Electrophoresis Fractionation><Caring><Cell Phone><Cell Phone Application><Cell phone App><Cellular Phone><Cellular Phone App><Cellular Phone Application><Cellular Telephone><Cheek><Cheek structure><Child><Child Mortality><Child Youth><Children (0-21)><Competence><Computer Reasoning><Computer software><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Cardiac Defects><Congenital Defects><Congenital Deformity><Congenital Heart Defects><Congenital Malformation><Copy Number Polymorphism><Country><Coupled><DNA seq><DNA sequencing><DNAseq><Data><Data Bases><Databases><Democratic Republic of the Congo><Detection><Development><Diagnosis><Diagnostic><Disease><Disorder><Down Syndrome><Early Diagnosis><Economic Income><Economical Income><Environment><Environmental Factor><Environmental Risk Factor><Ethics><Ethnic Origin><Ethnicity><Face><Family><Fellowship><Future><General Population><General Public><Genetic><Genetic Diseases><Genetic Materials><Health><Health Care><Health Care Providers><Health Personnel><Hearing><High Prevalence><Hospitals><Income><Individual><Infection><Infrastructure><International><Intervention><Laboratories><Langdon Down syndrome><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Machine Intelligence><Machine Learning><Materials Testing><Measures><Mobile Phones><Modeling><Mongolism><Morbidity><Morphology><Neonatal Screening><Newborn Infant><Newborn Infant Screening><Newborns><Nutrition><Other Genetics><Outcome><Patient risk><Persons><Phenotype><Photography><Physicians><Pilot Projects><Point Mutation><Population><Population Heterogeneity><Population Surveillance><Prevalence><Public Health><Public Health Surveillance><Publications><Registries><Research Institute><Research Resources><Resource Allocation><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Sampling><Scientific Publication><Services><Smart Phone App><Smart Phone Application><Smartphone App><Societies><Software><Students><Surveillance Program><Swab><Syndrome><System><Technology><Testing><Time><Training><Trisomy 21><Washington><Zaire><accurate diagnosis><active followup><app on a smartphone><application on a smartphone><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence based><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><artificial intelligence technology><artificial intelligence training><burden of disease><burden of illness><cell phone based app><chromosome 21 trisomy><chromosome 21 trisomy syndrome><computer scientist><computerized><congenital acromicria syndrome><congenital anomaly><copy number variant><copy number variation><cost><data acquisition><data acquisitions><data base><data registry><death risk><design><designing><developmental><diagnostic screening><diagnostic technologies><disability><disease burden><diverse populations><early detection><empowerment><enhanced with AI><enhanced with Artificial Intelligence><environmental risk><ethical><faces><facial><facial recognition software><follow up><follow-up><followed up><followup><gene-based diagnostics><genetic condition><genetic diagnosis><genetic diagnostics><genetic disorder><genetic disorder diagnosis><genetic etiology><genetic mechanism of disease><genetic resource><genetic-focused diagnostic><global health><health care personnel><health care quality><health care service><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><heterogeneous population><iOS app><iOS application><iPhone><iPhone App><iPhone Application><improved><incomes><indel><innovate><innovation><innovative><innovative technologies><insertion/deletion><insertion/deletion mutation><intervention program><kids><mHealth therapeutic><mHealth therapy><mHealth treatment><machine based learning><medical care providers><medical personnel><mhealth interventions><mobile DNA><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mobile phone app><morbus Down><mortality risk><neonatal health><new approaches><newborn child><newborn children><newborn health><newborn screening><novel><novel approaches><novel strategies><novel strategy><phone app><phone application><pilot study><point of care><population diversity><prevent><preventing><programs><pseudohypertrophic progressive muscular dystrophy><rapid diagnosis><screening><screenings><smart phone><smartphone><smartphone application><smartphone based app><smartphone based application><standard of care><tool><transposon/insertion element><treatment provider><trisomy 21 syndrome><youngster>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ngoyi Mumba

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 16/100
Active award
$78,869
FY 2026

Project Title

Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings

Grant Number:

3R33HD102988-04S1

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

SUMMARY Congenital anomalies represent an increasing burden of disease worldwide, accounting for millions of birth defect-related disabilities with a disproportionate impact on Low to Middle Income Countries (LIMCs). Many harbor genetic etiologies, for which no confirmatory diagnosis can be made due...

Research Terms

<0-11 years old><0-4 weeks old><AI Augmented><AI assisted><AI based><AI driven><AI enhanced><AI integrated><AI model training><AI powered><AI system><AI technology><AI training><Accounting><Active Follow-up><Address><Affect><Android App><Android Application><Aneuploid><Aneuploidy><Appearance><Artificial Intelligence><Artificial Intelligence enhanced><Artificial intelligence model training><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Belgian Congo><Biometrics><Biometry><Biostatistics><Birth Defects><Birth Rate><Bucca><Capillary Electrophoresis><Capillary Electrophoresis Fractionation><Caring><Cell Phone><Cell Phone Application><Cell phone App><Cellular Phone><Cellular Phone App><Cellular Phone Application><Cellular Telephone><Cheek><Cheek structure><Child><Child Mortality><Child Youth><Children (0-21)><Competence><Computer Reasoning><Computer software><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Cardiac Defects><Congenital Defects><Congenital Deformity><Congenital Heart Defects><Congenital Malformation><Copy Number Polymorphism><Country><Coupled><DNA seq><DNA sequencing><DNAseq><Data><Data Bases><Databases><Democratic Republic of the Congo><Detection><Development><Diagnosis><Diagnostic><Disease><Disorder><Down Syndrome><Early Diagnosis><Economic Income><Economical Income><Environment><Environmental Factor><Environmental Risk Factor><Ethics><Ethnic Origin><Ethnicity><Face><Family><Fellowship><Future><General Population><General Public><Genetic><Genetic Diseases><Genetic Materials><Health><Health Care><Health Care Providers><Health Personnel><Hearing><High Prevalence><Hospitals><Income><Individual><Infection><Infrastructure><International><Intervention><Laboratories><Langdon Down syndrome><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Machine Intelligence><Machine Learning><Materials Testing><Measures><Mobile Phones><Modeling><Mongolism><Morbidity><Morphology><Neonatal Screening><Newborn Infant><Newborn Infant Screening><Newborns><Nutrition><Other Genetics><Outcome><Patient risk><Persons><Phenotype><Photography><Physicians><Pilot Projects><Point Mutation><Population><Population Heterogeneity><Population Surveillance><Prevalence><Public Health><Public Health Surveillance><Publications><Registries><Research Institute><Research Resources><Resource Allocation><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Sampling><Scientific Publication><Services><Smart Phone App><Smart Phone Application><Smartphone App><Societies><Software><Students><Surveillance Program><Swab><Syndrome><System><Technology><Testing><Time><Training><Trisomy 21><Washington><Zaire><accurate diagnosis><active followup><app on a smartphone><application on a smartphone><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence based><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><artificial intelligence technology><artificial intelligence training><burden of disease><burden of illness><cell phone based app><chromosome 21 trisomy><chromosome 21 trisomy syndrome><computer scientist><computerized><congenital acromicria syndrome><congenital anomaly><copy number variant><copy number variation><cost><data acquisition><data acquisitions><data base><data registry><death risk><design><designing><developmental><diagnostic screening><diagnostic technologies><disability><disease burden><diverse populations><early detection><empowerment><enhanced with AI><enhanced with Artificial Intelligence><environmental risk><ethical><faces><facial><facial recognition software><follow up><follow-up><followed up><followup><gene-based diagnostics><genetic condition><genetic diagnosis><genetic diagnostics><genetic disorder><genetic disorder diagnosis><genetic etiology><genetic mechanism of disease><genetic resource><genetic-focused diagnostic><global health><health care personnel><health care quality><health care service><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><heterogeneous population><iOS app><iOS application><iPhone><iPhone App><iPhone Application><improved><incomes><indel><innovate><innovation><innovative><innovative technologies><insertion/deletion><insertion/deletion mutation><intervention program><kids><mHealth therapeutic><mHealth therapy><mHealth treatment><machine based learning><medical care providers><medical personnel><mhealth interventions><mobile DNA><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mobile phone app><morbus Down><mortality risk><neonatal health><new approaches><newborn child><newborn children><newborn health><newborn screening><novel><novel approaches><novel strategies><novel strategy><phone app><phone application><pilot study><point of care><population diversity><prevent><preventing><programs><pseudohypertrophic progressive muscular dystrophy><rapid diagnosis><screening><screenings><smart phone><smartphone><smartphone application><smartphone based app><smartphone based application><standard of care><tool><transposon/insertion element><treatment provider><trisomy 21 syndrome><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Eric J. Vilain

UNIVERSITY OF CALIFORNIA-IRVINE, IRVINE, CA

Exploratory lead · 16/100
Active award
$78,869
FY 2026

Project Title

Mobile Diagnosis of Congenital Genetic Conditions: A Model for Screening and Surveillance in Low-Resource Settings

Grant Number:

3R33HD102988-04S1

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

SUMMARY Congenital anomalies represent an increasing burden of disease worldwide, accounting for millions of birth defect-related disabilities with a disproportionate impact on Low to Middle Income Countries (LIMCs). Many harbor genetic etiologies, for which no confirmatory diagnosis can be made due...

Research Terms

<0-11 years old><0-4 weeks old><AI Augmented><AI assisted><AI based><AI driven><AI enhanced><AI integrated><AI model training><AI powered><AI system><AI technology><AI training><Accounting><Active Follow-up><Address><Affect><Android App><Android Application><Aneuploid><Aneuploidy><Appearance><Artificial Intelligence><Artificial Intelligence enhanced><Artificial intelligence model training><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Belgian Congo><Biometrics><Biometry><Biostatistics><Birth Defects><Birth Rate><Bucca><Capillary Electrophoresis><Capillary Electrophoresis Fractionation><Caring><Cell Phone><Cell Phone Application><Cell phone App><Cellular Phone><Cellular Phone App><Cellular Phone Application><Cellular Telephone><Cheek><Cheek structure><Child><Child Mortality><Child Youth><Children (0-21)><Competence><Computer Reasoning><Computer software><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Cardiac Defects><Congenital Defects><Congenital Deformity><Congenital Heart Defects><Congenital Malformation><Copy Number Polymorphism><Country><Coupled><DNA seq><DNA sequencing><DNAseq><Data><Data Bases><Databases><Democratic Republic of the Congo><Detection><Development><Diagnosis><Diagnostic><Disease><Disorder><Down Syndrome><Early Diagnosis><Economic Income><Economical Income><Environment><Environmental Factor><Environmental Risk Factor><Ethics><Ethnic Origin><Ethnicity><Face><Family><Fellowship><Future><General Population><General Public><Genetic><Genetic Diseases><Genetic Materials><Health><Health Care><Health Care Providers><Health Personnel><Hearing><High Prevalence><Hospitals><Income><Individual><Infection><Infrastructure><International><Intervention><Laboratories><Langdon Down syndrome><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Machine Intelligence><Machine Learning><Materials Testing><Measures><Mobile Phones><Modeling><Mongolism><Morbidity><Morphology><Neonatal Screening><Newborn Infant><Newborn Infant Screening><Newborns><Nutrition><Other Genetics><Outcome><Patient risk><Persons><Phenotype><Photography><Physicians><Pilot Projects><Point Mutation><Population><Population Heterogeneity><Population Surveillance><Prevalence><Public Health><Public Health Surveillance><Publications><Registries><Research Institute><Research Resources><Resource Allocation><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Sampling><Scientific Publication><Services><Smart Phone App><Smart Phone Application><Smartphone App><Societies><Software><Students><Surveillance Program><Swab><Syndrome><System><Technology><Testing><Time><Training><Trisomy 21><Washington><Zaire><accurate diagnosis><active followup><app on a smartphone><application on a smartphone><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence based><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><artificial intelligence technology><artificial intelligence training><burden of disease><burden of illness><cell phone based app><chromosome 21 trisomy><chromosome 21 trisomy syndrome><computer scientist><computerized><congenital acromicria syndrome><congenital anomaly><copy number variant><copy number variation><cost><data acquisition><data acquisitions><data base><data registry><death risk><design><designing><developmental><diagnostic screening><diagnostic technologies><disability><disease burden><diverse populations><early detection><empowerment><enhanced with AI><enhanced with Artificial Intelligence><environmental risk><ethical><faces><facial><facial recognition software><follow up><follow-up><followed up><followup><gene-based diagnostics><genetic condition><genetic diagnosis><genetic diagnostics><genetic disorder><genetic disorder diagnosis><genetic etiology><genetic mechanism of disease><genetic resource><genetic-focused diagnostic><global health><health care personnel><health care quality><health care service><health care worker><health provider><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><heterogeneous population><iOS app><iOS application><iPhone><iPhone App><iPhone Application><improved><incomes><indel><innovate><innovation><innovative><innovative technologies><insertion/deletion><insertion/deletion mutation><intervention program><kids><mHealth therapeutic><mHealth therapy><mHealth treatment><machine based learning><medical care providers><medical personnel><mhealth interventions><mobile DNA><mobile health intervention><mobile health therapeutic><mobile health therapy><mobile health treatment><mobile phone app><morbus Down><mortality risk><neonatal health><new approaches><newborn child><newborn children><newborn health><newborn screening><novel><novel approaches><novel strategies><novel strategy><phone app><phone application><pilot study><point of care><population diversity><prevent><preventing><programs><pseudohypertrophic progressive muscular dystrophy><rapid diagnosis><screening><screenings><smart phone><smartphone><smartphone application><smartphone based app><smartphone based application><standard of care><tool><transposon/insertion element><treatment provider><trisomy 21 syndrome><youngster>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

MICHAEL Ilya BUKRINSKY

GEORGE WASHINGTON UNIVERSITY, WASHINGTON, DC

Exploratory lead · 16/100
Active award
$71,609
FY 2026

Project Title

Epigenetic mechanisms of HAND pathogenesis

Grant Number:

3R21NS137986-01A1S1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/13/2024

End Date:

8/31/2026

Project Abstract

HIV-associated neurocognitive disorders (HAND) remain among the most prominent HIV co-morbidities in the era of ART-treated HIV infection. Persistent neuroinflammation is a recognized pathogenic feature of HAND, but the reason(s) for the inflammation persisting after initiation of ART remain incompl...

Research Terms

<AIDS Virus><ATAC sequencing><ATAC-seq><ATACseq><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Affect><Assay for Transposase-Accessible Chromatin using sequencing><Astrocytes><Astrocytus><Astroglia><BBB penetration><Bioinformatics><Blood monocyte><Brain><Brain Nervous System><Cell Body><Cell Nucleus><Cells><Cholesterol Homeostasis><Chromatin><Chronic><Collaborations><Data Set><Development><Drug usage><Elements><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exploratory/Developmental Grant><Exposure to><Foundations><Future><Gene Transcription><Genes><Genetic Transcription><Glia><Glial Cells><Goals><HIV><HIV 1 associated neurocognitive disorder><HIV Infections><HIV associated neurocognitive deficit><HIV associated neurocognitive impairment><HIV individuals><HIV induced neurocognitive deficit><HIV induced neurocognitive impairment><HIV infected individuals><HIV infected persons><HIV intervention><HIV load><HIV neurocognitive impairment><HIV people><HIV plasma viral load><HIV positive individuals><HIV positive people><HIV replication><HIV therapeutic><HIV therapy><HIV treatment><HIV viral burden><HIV viral infection><HIV viral load><HIV viral replication><HIV virus infection><HIV-1><HIV-1 associated neurocognitive deficit><HIV-1 associated neurocognitive disorder><HIV-1 associated neurocognitive impairment><HIV-1 infection><HIV-1 intervention><HIV-1 load><HIV-1 replication><HIV-1 therapeutic><HIV-1 therapy><HIV-1 treatment><HIV-1 viral burden><HIV-1 viral load><HIV-1 viral replication><HIV-1 virus replication><HIV-I><HIV-associated neurocognitive disorder><HIV1><Hortega cell><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus therapy><Human Immunodeficiency Virus treatment><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Immunity><Immunology><In Vitro><Individual><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Inflammation><Inflammatory><Inflammatory Response><Innate Immune Response><Investigation><Investigators><Kolliker's reticulum><LAV-HTLV-III><Lymphadenopathy-Associated Virus><Marrow monocyte><Memory><Metabolic><Methodology><Microglia><Modeling><Modification><Molecular><Myeloid Cells><Neurobiology><Neurocognitive Impairment in HIV><Neurocognitive Impairment in HIV-1><Neuroglia><Neuroglial Cells><Non-Polyadenylated RNA><Non-neuronal cell><Nonneuronal cell><Nucleus><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Outcome><PLWH><PWH><Pathogenesis><Pathogenicity><Pathogenicity Factors><Pathway interactions><Peripheral><Phenotype><QOL><Quality of life><R21 Mechanism><R21 Program><RNA><RNA Expression><RNA Gene Products><Research Personnel><Researchers><Ribonucleic Acid><Stimulus><Testing><Therapeutic><Training><Transcription><Viral Gene Products><Viral Gene Proteins><Viral Proteins><Virulence Factors><Virus><Virus-HIV><antiretroviral therapy><antiretroviral treatment><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><astrocytic glia><blood-brain barrier penetration><bloodbrain barrier penetration><brain cell><cell type><cholesterol metabolism><co-morbid><co-morbidity><comorbidity><develop therapy><developmental><drug use><epigenetic memory><epigenetically><exploratory developmental study><extracellular vesicles><gitter cell><high reward><high risk><human immunodeficiency virus infection><human immunodeficiency virus replication><human immunodeficiency virus-1 replication><humanized mice><humanized mouse><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><innovate><innovation><innovative><intervention development><mesoglia><microglial cell><microgliocyte><monocyte><mouse model><murine model><nef><nef Gene Products><nef Protein><nerve cement><neural inflammation><neurobiological><neuroinflammation><neuroinflammatory><neuropathologic><neuropathological><neuropathology><novel><pathogen><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><perivascular glial cell><response><therapy development><treat HIV><treat Human Immunodeficiency Virus><treatment development><virology><virus protein>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Dmitri Sviridov

GEORGE WASHINGTON UNIVERSITY, WASHINGTON, DC

Exploratory lead · 16/100
Active award
$71,609
FY 2026

Project Title

Epigenetic mechanisms of HAND pathogenesis

Grant Number:

3R21NS137986-01A1S1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/13/2024

End Date:

8/31/2026

Project Abstract

HIV-associated neurocognitive disorders (HAND) remain among the most prominent HIV co-morbidities in the era of ART-treated HIV infection. Persistent neuroinflammation is a recognized pathogenic feature of HAND, but the reason(s) for the inflammation persisting after initiation of ART remain incompl...

Research Terms

<AIDS Virus><ATAC sequencing><ATAC-seq><ATACseq><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Affect><Assay for Transposase-Accessible Chromatin using sequencing><Astrocytes><Astrocytus><Astroglia><BBB penetration><Bioinformatics><Blood monocyte><Brain><Brain Nervous System><Cell Body><Cell Nucleus><Cells><Cholesterol Homeostasis><Chromatin><Chronic><Collaborations><Data Set><Development><Drug usage><Elements><Encephalon><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Exploratory/Developmental Grant><Exposure to><Foundations><Future><Gene Transcription><Genes><Genetic Transcription><Glia><Glial Cells><Goals><HIV><HIV 1 associated neurocognitive disorder><HIV Infections><HIV associated neurocognitive deficit><HIV associated neurocognitive impairment><HIV individuals><HIV induced neurocognitive deficit><HIV induced neurocognitive impairment><HIV infected individuals><HIV infected persons><HIV intervention><HIV load><HIV neurocognitive impairment><HIV people><HIV plasma viral load><HIV positive individuals><HIV positive people><HIV replication><HIV therapeutic><HIV therapy><HIV treatment><HIV viral burden><HIV viral infection><HIV viral load><HIV viral replication><HIV virus infection><HIV-1><HIV-1 associated neurocognitive deficit><HIV-1 associated neurocognitive disorder><HIV-1 associated neurocognitive impairment><HIV-1 infection><HIV-1 intervention><HIV-1 load><HIV-1 replication><HIV-1 therapeutic><HIV-1 therapy><HIV-1 treatment><HIV-1 viral burden><HIV-1 viral load><HIV-1 viral replication><HIV-1 virus replication><HIV-I><HIV-associated neurocognitive disorder><HIV1><Hortega cell><Human Immunodeficiency Virus Type 1><Human Immunodeficiency Virus therapy><Human Immunodeficiency Virus treatment><Human Immunodeficiency Virus-1><Human Immunodeficiency Viruses><Human immunodeficiency virus 1><Immunity><Immunology><In Vitro><Individual><Infection by HIV-1><Infection from HIV-1><Infection of HIV-1><Inflammation><Inflammatory><Inflammatory Response><Innate Immune Response><Investigation><Investigators><Kolliker's reticulum><LAV-HTLV-III><Lymphadenopathy-Associated Virus><Marrow monocyte><Memory><Metabolic><Methodology><Microglia><Modeling><Modification><Molecular><Myeloid Cells><Neurobiology><Neurocognitive Impairment in HIV><Neurocognitive Impairment in HIV-1><Neuroglia><Neuroglial Cells><Non-Polyadenylated RNA><Non-neuronal cell><Nonneuronal cell><Nucleus><Oligodendrocytes><Oligodendrocytus><Oligodendroglia><Oligodendroglia Cell><Outcome><PLWH><PWH><Pathogenesis><Pathogenicity><Pathogenicity Factors><Pathway interactions><Peripheral><Phenotype><QOL><Quality of life><R21 Mechanism><R21 Program><RNA><RNA Expression><RNA Gene Products><Research Personnel><Researchers><Ribonucleic Acid><Stimulus><Testing><Therapeutic><Training><Transcription><Viral Gene Products><Viral Gene Proteins><Viral Proteins><Virulence Factors><Virus><Virus-HIV><antiretroviral therapy><antiretroviral treatment><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><astrocytic glia><blood-brain barrier penetration><bloodbrain barrier penetration><brain cell><cell type><cholesterol metabolism><co-morbid><co-morbidity><comorbidity><develop therapy><developmental><drug use><epigenetic memory><epigenetically><exploratory developmental study><extracellular vesicles><gitter cell><high reward><high risk><human immunodeficiency virus infection><human immunodeficiency virus replication><human immunodeficiency virus-1 replication><humanized mice><humanized mouse><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><infected with HIV><infected with human immunodeficiency virus><innovate><innovation><innovative><intervention development><mesoglia><microglial cell><microgliocyte><monocyte><mouse model><murine model><nef><nef Gene Products><nef Protein><nerve cement><neural inflammation><neurobiological><neuroinflammation><neuroinflammatory><neuropathologic><neuropathological><neuropathology><novel><pathogen><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><perivascular glial cell><response><therapy development><treat HIV><treat Human Immunodeficiency Virus><treatment development><virology><virus protein>
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MARGOT S. DAMASER

LOUIS STOKES CLEVELAND VA MEDICAL CENTER, CLEVELAND, OH

Exploratory lead · 16/100
Active award
$0
FY 2026

Project Title

RR&D Research Career Scientist Award Application - Renewal of Margot Damaser SRCS Award

Grant Number:

5IK6RX003843-05

Activity Code:

IK6

Mechanism:

Other

Agency:

VA

Start Date:

10/1/2021

End Date:

9/30/2028

Project Abstract

Summary/Abstract Dr. Margot Damaser is Senior Research Career Scientist in the RR&D Service of the US Department of Veterans Affairs and Professor of Biomedical Engineering in the Cleveland Clinic Lerner College of Medicine at Case Western Reserve University. She is Deputy Director and co-PI of the ...

Research Terms

<Acceleration><Activities of Daily Living><Activities of everyday life><Advisory Committees><Affect><Agreement><American><Anal Incontinence><Animal Experiments><Animal Model><Animal Models and Related Studies><Animals><Area><Award><Biomedical Engineering><Birth Injuries><Birth trauma><Bladder><Bladder Urinary System><Book Chapters><Books><Bowel incontinence><Brain Trauma><Breakthrough device><CNS Diseases><CNS disorder><Caring><Catheters><Central Nervous System Diseases><Central Nervous System Disorders><Clinic><Clinical><Collaborations><Conscious><Consciousness><Constipation><Development><Development and Research><Device Designs><Device or Instrument Development><Devices><Diabetes Mellitus><Diagnosis><Disease><Disorder><Dysfunction><E-stim><Elderly><Electric Stimulation><Engineering><Evaluation><Exercise><Extravasation><Fecal Incontinence><Female><Foundations><Functional disorder><Funding><Goals><Grant><Grant Review><Gymnastics><Homing><Human><IACUC><Impairment><Incontinence when straining><Institutional Animal Care and Use Committee><Interdisciplinary Research><Interdisciplinary Study><Intestinal><Intestines><Investigators><Investments><Joints><Journals><Kidney><Kidney Urinary System><Laboratory Research><Leakage><Legal patent><Licensing><Magazine><Manuscripts><Massachusetts><Measures><Medical><Medical Device><Medical Rehabilitation><Medicine><Mentors><Methods><Modeling><Modern Man><Monitor><Motivation><Multidisciplinary Collaboration><Multidisciplinary Research><Multiple Injuries><Multiple Trauma><Muscle><Muscle Tissue><NIH><Nanotechnology><National Institutes of Health><Natural regeneration><Nerve><Neurogenic Bladder><Neurogenic Bladder Disorder><Neurogenic Urinary Bladder Disorder><Neuropathic Bladder><Ohio><Organ><Paper><Parachuting><Patents><Pelvic Floor><Pelvic Floor Disorders><Pelvic floor structure><Physical activity><Physiology><Physiopathology><Position><Positioning Attribute><Prevalence><Productivity><Progenitor Cells><Publishing><R & D><R&D><R-Series Research Projects><R01 Mechanism><R01 Program><Recovery><Reference Standards><Regeneration><Regenerative Medicine><Regulatory approval><Rehabilitation><Rehabilitation therapy><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Resistance><Rodent><Rodentia><Rodents Mammals><Role><Running><Scientific Societies><Scientist><Services><Source><Spillage><Spinal Cord Trauma><Spinal Trauma><Spinal cord injured><Spinal cord injury><Stress Incontinence><Stress Urinary Incontinence><System><Task Forces><Technology><Testing><Training><Translating><Translational Research><Translational Science><Translations><Traumatic Brain Injury><Traumatic Myelopathy><United States Department of Veterans Affairs><United States National Institutes of Health><United States Veterans Administration><Universities><Urethra><Urinary Bladder Neurogenic Dysfunction><Urinary Incontinence><Urology><Vagina><Veterans><Veterans Administration><Veterans Affairs><Weight><Weight Lifting><Woman><advanced age><advisory team><animal experiment><bio-engineered><bio-engineers><bioengineering><biological engineering><bowel><career><clinical translation><clinically translatable><college><collegiate><daily living function><daily living functionality><developmental><device development><diabetes><diabetic><electrostimulation><experimental animal><experimental animals><functional ability><functional capacity><geriatric><human subject><improved><innovate><innovation><innovative><instrument development><member><minimally invasive><model of animal><muscular><nano tech><nano technology><nano-technological><nanotech><nanotechnological><nerve injury><neural injury><neurotrophic factor><neurotrophin><neutrophin><novel><overexpress><overexpression><pathophysiology><pelvic organ prolapse><peripheral nerve regeneration><polytrauma><professor><programs><regenerate><regenerative><regenerative approach><regenerative strategy><regenerative technique><regulatory authorization><regulatory certification><regulatory clearance><rehab research><rehab therapy><rehabilitation research><rehabilitative><rehabilitative therapy><renal><research and development><research in practice><resistant><senior citizen><social role><stem cells><technology platform><technology system><translation><translation research><translational investigation><translational opportunities><translational potential><traumatic brain damage><urethral><urinary bladder><weights><wireless><♀>
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SANJAY J MATHEW

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Exploratory lead · 10/100
Active award
$240,000
FY 2025

Project Title

Gamma oscillations as a prognostic marker for ketamine therapy in treatment resistant depression

Grant Number:

5R21MH133198-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2026

Project Abstract

Project Summary Treatment-resistant depression (TRD) is a significant public health issue and the leading cause of disability in young and middle-age adults. The FDA's approval of esketamine nasal spray for TRD and the rapid proliferation of clinics providing ketamine (KET) has markedly increased nu...

Research Terms

<21+ years old><Address><Adult><Adult Human><Age><Alcohol Drinking><Alcohol consumption><Biologic Models><Biological><Biological Markers><Biological Models><Bipolar Affective Psychosis><Bipolar Disorder><Brain><Brain Nervous System><Chemosensitization><Chemosensitization/Potentiation><Clinic><Clinical><Clinical Markers><Control Groups><Cross-Over Designs><Crossover Design><Development><Diagnosis><Disease><Disorder><Drug Kinetics><Drugs><EEG><Electroencephalogram><Electroencephalography><Elements><Emotional Depression><Encephalon><Equilibrium><EtOH drinking><EtOH use><Exclusion><Exploratory/Developmental Grant><Glutamates><Goals><Heterogeneity><Individual><Infusion><Infusion procedures><Intervention><Intravenous><Investigation><Ketamine><L-Glutamate><Link><Major Depressive Disorder><Manic-Depressive Psychosis><Measurement><Measures><Mechanics><Medication><Mental Depression><Methods><Model System><Modeling><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><NMDA Receptor-Ionophore Complex><NMDA Receptors><Nasal><Nasal Passages Nose><Nose><Outcome><PTSD><Patient Selection><Patients><Pattern><Pharmaceutical Preparations><Pharmacokinetics><Phase><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Potentiation><Precision care><Prediction of Response to Therapy><Procedures><Process><Prognosis><Prognostic Marker><Proliferating><Psychiatrist><Psychotherapy><Public Health><R21 Mechanism><R21 Program><Research><Resistance><Respiratory System, Nose, Nasal Passages><Rest><Saline><Saline Solution><Sampling><Schedule><Shapes><Synapses><Synaptic><System><Therapeutic><Treatment outcome><Variant><Variation><adulthood><ages><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><antagonism><antagonist><anti-depressant agent><anti-depressant drugs><anti-depressants><anti-depressive agents><balance><balance function><bio-markers><biologic><biologic marker><biomarker><bipolar affective disorder><bipolar disease><bipolar illness><bipolar mood disorder><candidate biomarker><candidate marker><clinical biomarkers><clinical depression><clinical practice><clinically useful biomarkers><community partners><community-based partners><cost><depressed patient><depression><depression symptom><depressive><depressive symptoms><developmental><disability><drug/agent><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><exploratory developmental study><glutamatergic><improve symptom><improved><individualized care><individualized patient care><infusions><innovate><innovation><innovative><major depression><major depression disorder><manic depressive disorder><manic depressive illness><mechanic><mechanical><methods to study multiple-level influences><mid life><mid-life><middle age><middle aged><midlife><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><neural circuit><neural circuitry><neural control><neural regulation><neurocircuitry><neuromodulation><neuromodulatory><neurophysiological><neurophysiology><neuroregulation><novel><personalized care><personalized patient care><post-trauma stress disorder><posttrauma stress disorder><pre-clinical study><preclinical study><predict therapeutic response><predict therapy response><prognostic><prognostic biomarker><prognostic indicator><prospective><psychotic><resistant><response><sex><success><symptom improvement><symptomatic improvement><synapse><synaptic circuit><synaptic circuitry><therapeutic stratification><therapy prediction><tool><translational opportunities><translational potential><traumatic neurosis><treatment prediction><treatment response prediction><treatment stratification><treatment-refractory depression><treatment-resistant depression><younger age>
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Nicholas Murphy

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Exploratory lead · 10/100
Active award
$240,000
FY 2025

Project Title

Gamma oscillations as a prognostic marker for ketamine therapy in treatment resistant depression

Grant Number:

5R21MH133198-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2026

Project Abstract

Project Summary Treatment-resistant depression (TRD) is a significant public health issue and the leading cause of disability in young and middle-age adults. The FDA's approval of esketamine nasal spray for TRD and the rapid proliferation of clinics providing ketamine (KET) has markedly increased nu...

Research Terms

<21+ years old><Address><Adult><Adult Human><Age><Alcohol Drinking><Alcohol consumption><Biologic Models><Biological><Biological Markers><Biological Models><Bipolar Affective Psychosis><Bipolar Disorder><Brain><Brain Nervous System><Chemosensitization><Chemosensitization/Potentiation><Clinic><Clinical><Clinical Markers><Control Groups><Cross-Over Designs><Crossover Design><Development><Diagnosis><Disease><Disorder><Drug Kinetics><Drugs><EEG><Electroencephalogram><Electroencephalography><Elements><Emotional Depression><Encephalon><Equilibrium><EtOH drinking><EtOH use><Exclusion><Exploratory/Developmental Grant><Glutamates><Goals><Heterogeneity><Individual><Infusion><Infusion procedures><Intervention><Intravenous><Investigation><Ketamine><L-Glutamate><Link><Major Depressive Disorder><Manic-Depressive Psychosis><Measurement><Measures><Mechanics><Medication><Mental Depression><Methods><Model System><Modeling><N-Methyl-D-Aspartate Receptors><N-Methylaspartate Receptors><NMDA Receptor-Ionophore Complex><NMDA Receptors><Nasal><Nasal Passages Nose><Nose><Outcome><PTSD><Patient Selection><Patients><Pattern><Pharmaceutical Preparations><Pharmacokinetics><Phase><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Posttraumatic Neuroses><Potentiation><Precision care><Prediction of Response to Therapy><Procedures><Process><Prognosis><Prognostic Marker><Proliferating><Psychiatrist><Psychotherapy><Public Health><R21 Mechanism><R21 Program><Research><Resistance><Respiratory System, Nose, Nasal Passages><Rest><Saline><Saline Solution><Sampling><Schedule><Shapes><Synapses><Synaptic><System><Therapeutic><Treatment outcome><Variant><Variation><adulthood><ages><alcohol ingestion><alcohol intake><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><antagonism><antagonist><anti-depressant agent><anti-depressant drugs><anti-depressants><anti-depressive agents><balance><balance function><bio-markers><biologic><biologic marker><biomarker><bipolar affective disorder><bipolar disease><bipolar illness><bipolar mood disorder><candidate biomarker><candidate marker><clinical biomarkers><clinical depression><clinical practice><clinically useful biomarkers><community partners><community-based partners><cost><depressed patient><depression><depression symptom><depressive><depressive symptoms><developmental><disability><drug/agent><ethanol consumption><ethanol drinking><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><exploratory developmental study><glutamatergic><improve symptom><improved><individualized care><individualized patient care><infusions><innovate><innovation><innovative><major depression><major depression disorder><manic depressive disorder><manic depressive illness><mechanic><mechanical><methods to study multiple-level influences><mid life><mid-life><middle age><middle aged><midlife><multi-level analysis><multi-level model><multilevel analysis><multilevel model><multilevel modeling><neural circuit><neural circuitry><neural control><neural regulation><neurocircuitry><neuromodulation><neuromodulatory><neurophysiological><neurophysiology><neuroregulation><novel><personalized care><personalized patient care><post-trauma stress disorder><posttrauma stress disorder><pre-clinical study><preclinical study><predict therapeutic response><predict therapy response><prognostic><prognostic biomarker><prognostic indicator><prospective><psychotic><resistant><response><sex><success><symptom improvement><symptomatic improvement><synapse><synaptic circuit><synaptic circuitry><therapeutic stratification><therapy prediction><tool><translational opportunities><translational potential><traumatic neurosis><treatment prediction><treatment response prediction><treatment stratification><treatment-refractory depression><treatment-resistant depression><younger age>
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Graham Hugh Diering

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 10/100
Active award
$226,306
FY 2025

Project Title

Developmental sleep disruption interacts with underlying CHD8 genetic vulnerability in autism spectrum disorder

Grant Number:

5R21MH135250-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY Autism spectrum disorder (ASD) is a common neurodevelopmental condition that affects social behavior and cognitive flexibility. Sleep disruption is a common comorbidity in ASD, observed in more than 80% of affected individuals. It has been debated whether sleep disruption in ASD is a...

Research Terms

<0-11 years old><21+ years old><ASD><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Ammon Horn><Animal Model><Animal Models and Related Studies><Assay><Autism><Autistic Disorder><Behavior><Bioassay><Biological Assay><Brain><Brain Nervous System><Budgets><Child><Child Youth><Children (0-21)><Cognitive><Cornu Ammonis><DNA mutation><Data><Development><Diagnosis><Drosophila><Drosophila genus><Dysfunction><Early Infantile Autism><Embryo Development><Embryogenesis><Embryonic Development><Encephalon><Enzyme Gene><Enzymes><Equilibrium><Excitatory Synapse><Exploratory/Developmental Grant><Exposure to><Fore-Brain><Forebrain><Functional disorder><Genes><Genetic Change><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic defect><Genetic mutation><Genetic propensity><Goals><Heterozygote><Hippocampus><Impairment><Individual><Infantile Autism><Inherited Predisposition><Inherited Susceptibility><Inhibitory Synapse><Kanner's Syndrome><Life><Literature><Medicine><Methodology><Mice><Mice Mammals><Modeling><Molecular><Morphology><Murine><Mus><Mutation><Nuclear><Patients><Phenotype><Physiopathology><Play><Position><Positioning Attribute><Predisposition><Prosencephalon><Proteins><Proteomics><Publishing><R21 Mechanism><R21 Program><Research><Risk Factors><Risk-associated variant><Rodent><Rodentia><Rodents Mammals><Role><Sampling><Scaffolding Protein><Severities><Sleep><Sleep Deprivation><Sleep disturbances><Social Behavior><Standardization><Structure><Susceptibility><Symptoms><Synapses><Synaptic><Testing><Work><aberrant sleep><adulthood><autism model><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><balance><balance function><behavior test><behavioral test><chromatin remodeling><co-morbid><co-morbidity><cohort><comorbidity><critical period><deficient sleep><density><developmental><disrupted sleep><disturbed sleep><expectation><exploratory developmental study><flexibility><flexible><fruit fly><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><genome mutation><heterozygosity><hippocampal><impaired sleep><inadequate sleep><insufficient sleep><irregular sleep><juvenile><juvenile human><kids><model of animal><model of autism spectrum disorder><mouse model><murine model><next generation><pathophysiology><postnatal><programs><resilience><resilient><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><sex><sleep debt><sleep deficiency><sleep deficit><sleep disruption><sleep dysregulation><sleep insufficiency><sleep loss><sleep/wake disruption><sleep/wake disturbance><social><social role><sociobehavior><sociobehavioral><success><synapse><synapse formation><synapse function><synaptic function><synaptogenesis><youngster>
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Rongxiao Zhang

UNIVERSITY OF MISSOURI-COLUMBIA, COLUMBIA, MO

Exploratory lead · 10/100
Active award
$219,624
FY 2025

Project Title

Treatment Planning System for Electron FLASH radiation therapy

Grant Number:

5R21CA277420-03

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/6/2024

End Date:

7/31/2026

Project Abstract

Abstract Ultra-high dose rate (UHDR) radiation delivery, termed FLASH radiotherapy (FLASH-RT), has the potential to reduce normal tissue damage, with significant clinical cancer treatment ramifications. Current evidence suggests that FLASH-RT reduces functional damage to normal brain, colon, lung, a...

Research Terms

<3-D><3-Dimensional><3D><Acute Radiation Syndrome><Address><Anatomic Sites><Anatomic structures><Anatomy><Animal Model><Animal Models and Related Studies><Animals><Assay><Basic Research><Basic Science><Bioassay><Biological Assay><Body Tissues><Brain><Brain Nervous System><Breast><Cancer Treatment><Canine Species><Canis familiaris><Chemical Fractionation><Clinical><Clinical Treatment><Colon><Communities><Complication><Computer software><Cutaneous Lymphoma><Data><Development><Dogs><Dogs Mammals><Dose><Dose Rate><Effectiveness><Electrons><Encephalon><Evaluation><Exploratory/Developmental Grant><FRACN><Fostering><Fractionation><Fractionation Radiotherapy><Future><Geometry><Goals><Grant><H+ element><Human><Hydrogen Ions><Industrialization><Informatics><Interruption><Lung><Lung Respiratory System><Malignant Melanoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Melanoma><Mice><Mice Mammals><Modeling><Modern Man><Monte Carlo Method><Monte Carlo algorithm><Monte Carlo calculation><Monte Carlo procedure><Monte Carlo simulation><Murine><Mus><Nature><Negative Beta Particle><Negatrons><Normal Tissue><Normal tissue morphology><Organ><Penetration><Photons><Physiologic pulse><Probabilistic Models><Probability><Probability Models><Protons><Pulse><R21 Mechanism><R21 Program><Radiation><Radiation Oncology><Radiation Physics><Radiation Toxicity><Radiation induced damage><Radiation therapy><Radiotherapeutics><Radiotherapy><Radiotoxicity><Research><Research Resources><Resources><Risk><Running><Site><Skin><Skin Lymphoma><Soft tissue sarcoma><Software><Statistical Models><Structure><System><Technology><Therapeutic><Therapy Clinical Trials><Time><Tissues><Translations><Tumor Tissue><Work><anti-cancer therapy><beamline><cancer therapy><cancer-directed therapy><canine><clinical intervention><clinical relevance><clinical research site><clinical site><clinical therapy><clinical translation><clinically relevant><clinically translatable><commercialization><conventional therapy><conventional treatment><design><designing><developmental><domestic dog><dosimetry><electron energy><exploratory developmental study><field based data><field learning><field study><field test><high risk><insight><invention><irradiation><model of animal><phenomenological models><phenomenology><pilot trial><pre-clinical><pre-clinical study><preclinical><preclinical study><prototype><quality assurance><radiation damage><radiation delivery><radiation poisoning><radiation resistant><radiation treatment><radioresistant><resistant to radiation><response><simulation environment><statistical linear mixed models><statistical linear models><therapy optimization><three dimensional><translation><translation to humans><translational study><treatment optimization><treatment planning><treatment planning system><treatment with radiation><trial regimen><trial treatment><tumor>
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John Rudolph Blosnich

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Exploratory lead · 10/100
Active award
$213,719
FY 2025

Project Title

The Roles of Parental Mental Health and Help-Seeking: Utilizing a Family Systems Approach to Upstream Suicide Prevention for Sexual Minority Youth

Grant Number:

5R21MD019829-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/20/2024

End Date:

6/30/2026

Project Abstract

Project Summary Before leaving high school, approximately 1 in 4 sexual minority adolescents will attempt to end their own life; a rate that is nearly four times higher than their heterosexual peers. Social determinants in the family context through parental acceptance or rejection is a major, consi...

Research Terms

<0-11 years old><14 year old><14 years of age><Address><Adolescent><Adolescent Youth><Age><Application Context><Attitude><Behavior><Cause of Death><Child><Child Youth><Children (0-21)><Communities><Complex><Data><Development><Distress><Emotional Depression><Exploratory/Developmental Grant><Family><Feeling suicidal><Fostering><Gays><Generations><Goals><Health><Health equity research><Heterosexuals><High School Student><Home><Individual><Intervention><Interview><LGB><Lesbian><Lesbian Gay Bi-Sexual><Lesbian Gay Bisexual><Life><Literature><Longitudinal Surveys><Medical><Medical emergency><Mental Health><Mental Hygiene><Methods><NCMHD><NIMHD><National Center on Minority Health and Health Disparities><National Institute of Minority Health and Health Disparities><National Institute on Minority Health and Health Disparities><Nature><Parents><Pathway interactions><Personal Satisfaction><Phase><Population><Position><Positioning Attribute><Prevention><Process><Psychological Health><R21 Mechanism><R21 Program><Reaction><Reporting><Research><Research Resources><Research in health equity><Resources><Respondent><Rest><Risk><Risk Factors><Role><Sampling><Schools><Secondary School Student><Secondary Student><Sex Orientation><Sexual Orientation><Stress><Structure><Suggestion><Suicidal thoughts><Suicide><Suicide attempt><Suicide precaution><Suicide prevention><Survey Instrument><Surveys><System><Testing><Time Study><Victimization><Work><adult youth><age 14 years><ages><assess effectiveness><cohort><contextual factors><cost><depression symptom><depressive><depressive symptoms><determine effectiveness><develop therapy><developmental><disparity in health><effectiveness assessment><effectiveness evaluation><evaluate effectiveness><examine effectiveness><experience><exploratory developmental study><family support><fatal attempt><fatal suicide><fourteen year old><fourteen years of age><gender minority><gender minority group><gender minority individual><gender minority people><gender minority population><health disparity><health equity-focused research><help seeking><help-seeking behavior><high school><high schoolers><homes><implementation efforts><implementation study><improved><intent to die><interest><intervention development><juvenile><juvenile human><kids><non fatal attempt><nonfatal attempt><parent><parent role><parental role><pathway><peer><prevent suicidality><prevent suicide><recruit><reduce suicidality><reduce suicide><reducing suicidality><reducing suicide><research on health equity><research related to health equity><research to attain health equity><sexual disparity><sexual minority><sexual minority adolescent><sexual minority children><sexual minority health disparity><sexual minority youth><social><social determinants><social role><sociodeterminant><suicidal attempt><suicidal behavior><suicidal ideation><suicidal morbidity><suicidal risk><suicidal thinking><suicidality prevention><suicide behavior><suicide death><suicide ideation><suicide intervention><suicide morbidity><suicide risk><suicides><therapy development><thoughts about suicide><treatment development><well-being><wellbeing><young adult><young adult age><young adulthood><younger age><youngster>
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Susan Marie DE LUCA

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Exploratory lead · 10/100
Active award
$213,719
FY 2025

Project Title

The Roles of Parental Mental Health and Help-Seeking: Utilizing a Family Systems Approach to Upstream Suicide Prevention for Sexual Minority Youth

Grant Number:

5R21MD019829-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/20/2024

End Date:

6/30/2026

Project Abstract

Project Summary Before leaving high school, approximately 1 in 4 sexual minority adolescents will attempt to end their own life; a rate that is nearly four times higher than their heterosexual peers. Social determinants in the family context through parental acceptance or rejection is a major, consi...

Research Terms

<0-11 years old><14 year old><14 years of age><Address><Adolescent><Adolescent Youth><Age><Application Context><Attitude><Behavior><Cause of Death><Child><Child Youth><Children (0-21)><Communities><Complex><Data><Development><Distress><Emotional Depression><Exploratory/Developmental Grant><Family><Feeling suicidal><Fostering><Gays><Generations><Goals><Health><Health equity research><Heterosexuals><High School Student><Home><Individual><Intervention><Interview><LGB><Lesbian><Lesbian Gay Bi-Sexual><Lesbian Gay Bisexual><Life><Literature><Longitudinal Surveys><Medical><Medical emergency><Mental Health><Mental Hygiene><Methods><NCMHD><NIMHD><National Center on Minority Health and Health Disparities><National Institute of Minority Health and Health Disparities><National Institute on Minority Health and Health Disparities><Nature><Parents><Pathway interactions><Personal Satisfaction><Phase><Population><Position><Positioning Attribute><Prevention><Process><Psychological Health><R21 Mechanism><R21 Program><Reaction><Reporting><Research><Research Resources><Research in health equity><Resources><Respondent><Rest><Risk><Risk Factors><Role><Sampling><Schools><Secondary School Student><Secondary Student><Sex Orientation><Sexual Orientation><Stress><Structure><Suggestion><Suicidal thoughts><Suicide><Suicide attempt><Suicide precaution><Suicide prevention><Survey Instrument><Surveys><System><Testing><Time Study><Victimization><Work><adult youth><age 14 years><ages><assess effectiveness><cohort><contextual factors><cost><depression symptom><depressive><depressive symptoms><determine effectiveness><develop therapy><developmental><disparity in health><effectiveness assessment><effectiveness evaluation><evaluate effectiveness><examine effectiveness><experience><exploratory developmental study><family support><fatal attempt><fatal suicide><fourteen year old><fourteen years of age><gender minority><gender minority group><gender minority individual><gender minority people><gender minority population><health disparity><health equity-focused research><help seeking><help-seeking behavior><high school><high schoolers><homes><implementation efforts><implementation study><improved><intent to die><interest><intervention development><juvenile><juvenile human><kids><non fatal attempt><nonfatal attempt><parent><parent role><parental role><pathway><peer><prevent suicidality><prevent suicide><recruit><reduce suicidality><reduce suicide><reducing suicidality><reducing suicide><research on health equity><research related to health equity><research to attain health equity><sexual disparity><sexual minority><sexual minority adolescent><sexual minority children><sexual minority health disparity><sexual minority youth><social><social determinants><social role><sociodeterminant><suicidal attempt><suicidal behavior><suicidal ideation><suicidal morbidity><suicidal risk><suicidal thinking><suicidality prevention><suicide behavior><suicide death><suicide ideation><suicide intervention><suicide morbidity><suicide risk><suicides><therapy development><thoughts about suicide><treatment development><well-being><wellbeing><young adult><young adult age><young adulthood><younger age><youngster>
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Aimalohi Ahonkhai

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Active award
$211,305
FY 2025

Project Title

An interactive, narrative intervention to address the mental health treatment gap among young people living with HIV in Nigeria

Grant Number:

5R33HD106578-06

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/8/2024

End Date:

6/30/2026

Project Abstract

PROJECT SUMMARY Young people living with HIV (Y-PLWH) have poor adherence to antiretroviral therapy and engagement in HIV care, making HIV the leading cause of death for African adolescents. Depression and psychological distress are much more common among Y-PLWH than in the general population, and a...

Research Terms

<AIDS Virus><Access to Care><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adherence><Adolescent><Adolescent Youth><Adopted><Africa><Africa South of the Sahara><African><Appointment><COVID-19><CV-19><Care Givers><Caregivers><Caring><Cause of Death><Cell Phone><Cellular Phone><Cellular Telephone><Climate><Clinic><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Coronavirus Infectious Disease 2019><Country><Development><Diagnosis><Disease remission><Distress><Effectiveness><Emotional><Epidemiology><Exploratory/Developmental Grant><Friends><Funding Opportunities><Future><General Population><General Public><Goals><HIV><Health><Health Care Professional><Health Care Technology><Health Professional><Health Promotion><Health Services Accessibility><Health Technology><Home><Human Immunodeficiency Viruses><Individual><Interdisciplinary Research><Interdisciplinary Study><Intervention><Investigators><Knowledge><LAV-HTLV-III><LMIC><Lymphadenopathy-Associated Virus><Mental Depression><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Mental disorders><Mental health disorders><Meteorological Climate><Mobile Phones><Multidisciplinary Collaboration><Multidisciplinary Research><Nigeria><Non-Profit Organizations><Nonprofit Organizations><Outcome><Ownership><Patients><Persons><Play><Population><Provider><Psychiatric Disease><Psychiatric Disorder><Psychiatric Social Service><Psychiatric Social Work><Psychological Health><Psychotherapy><Public Health><R21 Mechanism><R21 Program><Randomized, Controlled Trials><Recommendation><Remission><Research><Research Personnel><Researchers><Role><Salutogenesis><Side><Social Impacts><Sub-Saharan Africa><Subsaharan Africa><Technology><Testing><Therapeutic Intervention><Training><Treatment outcome><Universities><Virus-HIV><Visit><World Health Organization><Youth><Youth 10-21><acceptability and feasibility><access to health services><access to services><access to treatment><accessibility to health services><age group><antiretroviral therapy><antiretroviral treatment><availability of services><barriers to implementation><care access><care providers><climatic><co-morbid><co-morbidity><comorbidity><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><cost><depression><design><designing><developmental><digital><disease control><disorder control><drug adherence><drug compliance><effectiveness-implementation RCT><effectiveness-implementation randomized control trial><effectiveness-implementation randomized controlled trial><effectiveness/implementation hybrid><epidemic containment><epidemic control><epidemic mitigation><epidemic response><epidemiologic><epidemiological><evidence base><experience><exploratory developmental study><handheld mobile device><health service access><health services availability><homes><iPhone><implementation barriers><implementation challenges><implementation science><improved><innovate><innovation><innovative><interest><intervention delivery><intervention therapy><juvenile><juvenile human><low and middle-income countries><m-Health><mHealth><medication adherence><medication compliance><mental health care><mental illness><mental training><mobile device><mobile health><multidisciplinary><novel><problem solving therapy><promoting health><prototype><psychiatric illness><psychologic><psychological><psychological disorder><psychological distress><psychosocial service><randomized control trial><satisfaction><screening><screenings><service availability><smart phone><smartphone><social cognitive theory><social learning theory><social role><social stigma><stakeholder insights><stakeholder perspectives><stigma><telephone based><theories><treatment access><usability><virtual environment><youth age>
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Lalita A. Shevde

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 10/100
Active award
$208,271
FY 2025

Project Title

Targeting actionable liabilities in Merlin-deficient breast cancer

Grant Number:

5R21CA277267-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/27/2023

End Date:

11/30/2026

Project Abstract

ABSTRACT During tumor progression, loss of cell:cell adhesion and detachment from the extracellular matrix induces dynamic reorganization of the cytoskeleton, formation of invadopodia by the tumor cells, and activation of epithelial-to-mesenchymal transition. This is enabled by tuning molecular prog...

Research Terms

<Acceleration><Actins><Adhesions><Biologic Models><Biological Models><Body Tissues><Breast Cancer><Breast Cancer Cell><Breast Cancer Model><Breast Neoplasms><Breast Tumors><Breast tumor model><Cancers><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Signaling><Cell Survival><Cell Viability><Cell-Cell Adhesion><Cell-Extracellular Matrix><Cells><Cellular Matrix><Cellular Proliferation><Chemoresistance><Clinical Trials><Cytoskeletal Gene><Cytoskeletal Modeling><Cytoskeletal Organization><Cytoskeletal Organization Process><Cytoskeletal Proteins><Cytoskeletal Reorganization><Cytoskeletal System><Cytoskeleton><DNA mutation><Development><Diagnosis><ECM><Ectoderm><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Epithelium><Erinaceidae><Exploratory/Developmental Grant><Extracellular Matrix><F-Actin><FDA approved><Failure><Filamentous Actin><Foundations><Gene Family><Generalized Growth><Genetic Change><Genetic defect><Genetic mutation><Goals><Growth><Hedgehogs><Immune Evasion><Immunosuppression><Immunosuppression Effect><Immunosuppressive Effect><Immunotherapeutic agent><Intracellular Communication and Signaling><Investigation><KO mice><Knock-out><Knock-out Mice><Knockout><Knockout Mice><L-tryptophanase><Link><Malignant Breast Neoplasm><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Mammary Cancer><Mammary Neoplasms><Membrane><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Merlin><Metastasis><Metastasize><Metastatic Lesion><Metastatic Mass><Metastatic Neoplasm><Metastatic Tumor><Metastatic breast cancer><Mice><Mice Mammals><Model System><Modeling><Moesin-Ezrin-Radixin-Like Protein><Molecular><Morphology><Murine><Mus><Mutation><NF2><NF2 Gene Product><NF2 gene><Neoplasm Metastasis><Nervous System><Neurofibromatosis 2 Gene Product><Neurofibromatosis 2 Genes><Neurofibromatosis Type 2 Protein><Neurofibromin 2><Neurologic Body System><Neurologic Organ System><Nodal><Non-metastatic><Nonmetastatic><Null Mouse><Oral><Organoids><Outcome><Patients><Phenotype><Process><Proliferating><Protein Family><Proteins><R21 Mechanism><R21 Program><Receptor Protein><Reporting><Role><Scaffolding Protein><Schwannomerlin><Schwannomin><Schwannomin Protein><Secondary Neoplasm><Secondary Tumor><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Surface Proteins><System><TDO2><TRPO><Testing><Tissue Growth><Tissues><Translating><Tryptamin 2,3-Dioxygenase><Tryptophan 2,3-Dioxygenase><Tryptophan Indole-Lyase><Tryptophan Metabolism><Tryptophan Metabolism Pathway><Tryptophanase><Tumor Cell><Tumor Suppressor Proteins><Tumor Tissue><Tumor-Derived><Work><biological signal transduction><breast tumor cell><cancer cell><cancer metastasis><cancer progression><chemoresistant><chemotherapy resistance><chemotherapy resistant><clinical relevance><clinically relevant><developmental><epithelial to mesenchymal transition><exploratory developmental study><ezrin><genetic approach><genetic strategy><genome mutation><immune drugs><immune evasive><immune suppression><immune suppressive activity><immune suppressive function><immune-based therapeutics><immunologic therapeutics><immunosuppressive activity><immunosuppressive function><immunosuppressive response><immunotherapeutics><immunotherapy agent><infiltrating duct carcinoma><infiltrating ductal adenocarcinoma><infiltrating ductal carcinoma><inhibitor><innovate><innovation><innovative><intracellular skeleton><invasive ductal adenocarcinoma><invasive ductal carcinoma><malignancy><malignant breast tumor><mammary><mammary cancer model><mammary tumor><mammary tumor model><member><membrane structure><membrane-organizing extension spike protein><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><metastatic breast tumor><metastatic mammary cancer><metastatic mammary tumor><migration><moesin><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutics><new therapy><new therapy approaches><new treatment approach><new treatment strategy><next generation therapeutics><nf 2 Genes><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutics><novel therapy><novel therapy approach><ontogeny><permissiveness><pharmacologic><phosphoprotein p81><pre-clinical study><preclinical study><programs><protein expression><radixin><radixin protein><receptor><receptor-mediated signaling><social role><targeted agent><therapeutic evaluation><therapeutic testing><translatable strategy><tumor><tumor cell metastasis><tumor progression><tumor suppressor><tumorigenic>
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Ehren L. Newman

TRUSTEES OF INDIANA UNIVERSITY, BLOOMINGTON, IN

Exploratory lead · 10/100
Active award
$198,125
FY 2025

Project Title

Hippocampal-dependent spatial memory encoding during attentive processing from place

Grant Number:

5R21MH135251-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/18/2023

End Date:

11/30/2026

Project Abstract

Project Summary / Abstract Spatial memory is a core competency necessary for healthy independent living and for animal survival. While the hippocampus is well-established to be necessary for spatial memory, it remains poorly understood when and what the hippocampus does to support spatial memory. St...

Research Terms

<Address><Ammon Horn><Animals><Attention><Behavior><Behavioral><Categories><Chronic><Code><Coding System><Cognitive><Cognitive Retention Disorders><Common Rat Strains><Competence><Cornu Ammonis><Cues><Cyclicity><Data><Dorsal><Electrophysiology><Electrophysiology (science)><Environment><Event><Exploratory Behavior><Exploratory/Developmental Grant><Foundations><Goals><Health><Hippocampus><Human><Impairment><Implant><Independent Living><Investigation><Learning><Leg><Locomotion><Maps><Mediating><Memory><Memory Disorders><Mental Health><Mental Hygiene><Modern Man><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Neurophysiology / Electrophysiology><Outcome><Performance><Periodicity><Pilot Projects><Population><Position><Positioning Attribute><Process><Psychological Health><Qualifying><R21 Mechanism><R21 Program><Rat><Rats Mammals><Rattus><Research><Rest><Rhythmicity><Rodent><Rodentia><Rodents Mammals><Sampling><Testing><Update><Work><behavior study><behavioral study><density><electrophysiological><experience><experiment><experimental research><experimental study><experiments><exploratory developmental study><extracellular><high risk><hippocampal><improved><memory encoding><neuronal><novel><optogenetics><pilot study><programs><spatial memory>
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TIMOTHY A. GILBERTSON

UNIVERSITY OF CENTRAL FLORIDA, ORLANDO, FL

Exploratory lead · 10/100
Active award
$187,303
FY 2025

Project Title

Fatty acid signaling in distinct taste cell types

Grant Number:

5R21DC021103-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY Recent data has shown that individual taste modalities may not be completely segregated with specific cell types in the taste bud which has begun to question the strict roles previously attributed to the various subsets of cells within the mammalian taste bud. Using fatty acid taste...

Research Terms

<Address><Appetite><Assay><Bioassay><Biological Assay><CD36><CD36 gene><Calcium><Causality><Cell Body><Cell Communication and Signaling><Cell Function><Cell Physiology><Cell Process><Cell Signaling><Cells><Cellular Function><Cellular Physiology><Cellular Process><Conflict><Conflict (Psychology)><Data><Desire for food><Detection><Development><Diabetes Mellitus><Diet><Dietary Fats><Differences between sexes><Differs between sexes><Disease><Disorder><Drug Therapy><Eating><Elements><Endocrine Gland Secretion><Endocrine system><Endocrine/Metabolic Organ System><Essential Fatty Acids><Estrus><Etiology><Exercise><Exhibits><Exploratory/Developmental Grant><Fats><Fatty Acids><Fatty acid glycerol esters><Female><Food Intake><Free Fatty Acids><GP3B><GP4><GPIV><GPR84><GPR84 gene><Gene Expression><Goals><Gustation><Health><Hormonal System><Hormones><Image><Individual><Ingestion><Intake><Intracellular Communication and Signaling><Investigation><Ions><LTRPC5><Link><Long Transient Receptor Potential Channel 5><MLSN1- and TRP-Related Gene 1><MTR1><Mediating><Medium chain fatty acid><Metabolic/Endocrine Body System><Mice><Mice Mammals><Minor><Modality><Modeling><Molecular><Murine><Mus><NIH><National Institutes of Health><Nature><Nonesterified Fatty Acids><Nutrient><Nutritional status><Obesity><Obesity Epidemic><Oophorectomy><Ovariectomy><Overnutrition><Pathway interactions><Peripheral><Pharmacological Treatment><Pharmacotherapy><Play><Poison><Polyunsaturated Fatty Acids><Proestrus><R21 Mechanism><R21 Program><Receptor Protein><Regulation><Research><Role><SCARB3><STIM1><STIM1 gene><Saturated Fatty Acids><Science><Sensory><Sex Differences><Sexual differences><Signal Transduction><Signal Transduction Systems><Signaling><Specificity><Stimulus><Stromal Interaction Molecule 1><Subcellular Process><TRPM5><TRPM5 gene><Taste><Taste Buds><Taste Perception><Testing><Therapeutic Hormone><Toxic Chemical><Toxic Substance><Transient Receptor Potential Cation Channel, Subfamily M, Member 5><Type II Cell><Type II Epithelial Receptor Cell><Type III Cell><Type III Epithelial Receptor Cell><United States National Institutes of Health><Unsaturated Fatty Acids><adiposity><biological signal transduction><causation><cell type><comparative><corpulence><design><designing><developmental><diabetes><dietary><dietary lipid><diets><disease causation><drug intervention><drug treatment><endocrine gland/system><estrous><experience><experiment><experimental research><experimental study><experiments><exploratory developmental study><female gonadectomy><gene manipulation><genetic manipulation><genetically manipulate><genetically perturb><gustatory perception><gustatory processing><gustatory response><gustatory system><imaging><ingest><long chain fatty acid><male><mechanical cue><mechanical signal><model organism><patch clamp><pathway><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><programs><receptor><response><saturated dietary fat><saturated dietary lipid><saturated fat><saturated lipid><segregation><sex><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><signal processing><social role><taste processing><taste receptor><taste response><taste system><toxic compound><western diet><western-style diet><western-type diet><♀><♂>
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Dana Gaddy

TEXAS A&M AGRILIFE RESEARCH, College Station, TX

Exploratory lead · 10/100
Active award
$186,261
FY 2025

Project Title

Respiratory Distress in Sheep with Hypophosphatasia: Etiology, Functional Consequences and Rescue

Grant Number:

5R21HD114076-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/19/2024

End Date:

7/31/2026

Project Abstract

Project Summary This new R21 application “Respiratory Distress in Sheep with Hypophosphatasia: Etiology, Functional Consequences and Rescue” will provide novel insights into the role of tissue non-specific alkaline phosphatase (TNSALP) on lung development and function. Hypophosphatasia (HPP) is an i...

Research Terms

<Age><Age Months><Alkaline Phosphatase><Alveolar><Ammonia><Anesthesia><Anesthesia procedures><Animal Model><Animal Models and Related Studies><Architecture><Arteries><Bacterial Infections><Bicarbonates><Birth><Blood><Blood Reticuloendothelial System><Blood gas><Body Tissues><Bronchioalveolar Lavage><Bronchoalveolar Lavage><Bronchoalveolar Lavage Fluid><Bronchopulmonary Lavage><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Candidate Disease Gene><Candidate Gene><Cas nuclease technology><Causality><Cell Body><Cells><Clinical><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Conceptus><DNA Therapy><Developing fetus><Development><Diaphragm><Disease><Disorder><Dysfunction><Engineering / Architecture><Etiology><Exons><Exploratory/Developmental Grant><Fertilized Egg><Fertilized Ovum><Fetal Development><Fetal Lung><Fetus><Functional disorder><Gene Alteration><Gene Mutation><Gene Transfer Clinical><Generalized Growth><Genes><Genetic Intervention><Gestation><Growth><HCO3><Hereditary Disease><Histology><Human><Hydrogen Carbonates><Hypophosphatasia><Immune><Immunes><Impairment><Inborn Genetic Diseases><Incidence><Individual><Inflammation><Inflammatory><Inherited disorder><Intermediary Metabolism><Investigation><Laboratories><Life><Lung><Lung Lavage><Lung Respiratory System><Measures><Metabolic Processes><Metabolism><Mice><Mice Mammals><Minerals><Modeling><Modern Man><Murine><Mus><Musculoskeletal Development><Musculoskeletal System><Musculoskeletal System Development><Neonatal><Neonatal Mortality><Ovine><Ovis><Parturition><Pathogenesis><Patients><Phase><Phenotype><Physiopathology><Pneumonia><Position><Positioning Attribute><Postnatal respiratory distress><Pregnancy><Protein Analysis><Pulmonary Pathology><R21 Mechanism><R21 Program><Recombinants><Reporting><Respiration><Respiratory Diaphragm><Respiratory Disease><Respiratory System Disease><Respiratory System Disorder><Respiratory distress><Respiratory physiology><Rest><Rewards><Ribs><Risk><Role><Ruminantia><Ruminants><Sheep><Structure><Testing><Time><Tissue Growth><Tissues><Veterinarians><ages><alkaline phosphomonoesterase><bacteria infection><bacterial disease><bronchiolar alveolar lavage><bronchopulmonary lavage therapy><candidate validation><causation><death among neonates><death among newborns><death in neonates><death in newborn><determine efficacy><developmental><disease causation><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><exploratory developmental study><gene defect><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genomic therapy><glycerophosphatase><hereditary disorder><heritable disorder><in utero><inborn error><inherited diseases><inherited genetic disease><inherited genetic disorder><innovate><innovation><innovative><insight><locomotor system><loss of function mutation><lung development><lung function><lung pathology><mineralization><model of animal><mortality among neonates><mortality among newborns><mortality in neonates><mortality in newborns><mouse model><murine model><mutant allele><neonatal death><neonatal demise><neonatal morbidity><neonate><newborn death><newborn morbidity><newborn mortality><novel><ontogeny><ovine animal model><ovine model><pathophysiology><post-natal respiratory distress><postnatal><pulmonary function><respiratory><respiratory distress syndrome><respiratory function><respiratory mechanism><rib bone structure><scRNA sequencing><scRNA-seq><sheep model><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><zygote>
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Hongtu Chen

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Active award
$173,865
FY 2025

Project Title

Mobile application for early detection and intervention to reduce psychological distress in informal family caregivers of community dwelling adults with chronic disorders in Thailand

Grant Number:

4R33MH131043-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

7/31/2028

Project Abstract

Project Summary In lower-and-middle income countries (LMICs) like Thailand, family members providing care for adults with chronic disorders experience similar levels of mental health risks to that of their counterparts in higher income countries but have significantly more limited access to mental ...

Research Terms

<21+ years old><Activities of Daily Living><Activities of everyday life><Adult><Adult Human><Anxiety><Behavioral><Care Givers><Care giver intervention><Caregivers><Caring><Chronic Disease><Chronic Illness><Clinical><Communities><Computer software><Country><Death Rate><Development><Diagnosis><Distress><Early Diagnosis><Early Intervention><Economic Income><Economical Income><Effectiveness><Emotional Depression><Employment><Ensure><Evidence based intervention><Family Care Giver><Family Caregiver><Family member><Financial Hardship><Frequencies><Goals><Health><Health Care Technology><Health Technology><Income><Individual><Institutionalization><Intervention><Interview><LMIC><Mental Depression><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Mental disorders><Mental health disorders><Mobile Health App><Mobile Health Application><Outcome><Output><Participant><Patients><Persons><Phased Innovation Awards><Prevention><Privacy><Provider><Psychiatric Disease><Psychiatric Disorder><Psychologic Stress><Psychological Health><Psychological Stress><Qualitative Research><R21/R33 Mechanism><R21/R33 Program><Reporting><Research><Risk><Self Care><Self Efficacy><Software><Technology><Testing><Thailand><Training><Western World><adulthood><adverse consequence><adverse outcome><app based delivery><app delivery><app-delivered><assess effectiveness><burn-out><burnout><care giving><care receiver><care recipients><care seeking><caregiver interventions><caregiving><chronic disorder><compare to control><comparison control><coping mechanism><daily living function><daily living functionality><depression><depression symptom><depressive><depressive symptoms><design><designing><determine effectiveness><developmental><digital health><digital mental health><e-Health><eHealth><early detection><effectiveness assessment><effectiveness evaluation><electronic health><evaluate effectiveness><evidence base><examine effectiveness><experience><experimental arm><fall risk><financial adversity><financial burden><financial distress><financial insecurity><financial strain><financial stress><formative assessment><formative evaluation><functional ability><functional capacity><health and care delivery><health care delivery><health delivery systems><health services delivery><improved><incomes><innovate><innovation><innovative><literacy><low and middle-income countries><m-Health><m-Health app><m-Health application><mHealth><mHealth app><mHealth application><mental health care><mental illness><mobile app><mobile application><mobile application delivered><mobile application delivery><mobile computing><mobile device application><mobile health><mobile platform><mobile technology><mortality rate><mortality ratio><personal care><prevent><preventing><programs><psychiatric illness><psychological disorder><psychological distress><randomized, clinical trials><routine care><social cultural factor><social culture><social culture determinant><social stigma><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><stigma><stressor><success><technology intervention><technology-based interventions><technology-enabled interventions><technology-focused interventions><usability>
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Komatra Chuengsatiansup

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Active award
$173,865
FY 2025

Project Title

Mobile application for early detection and intervention to reduce psychological distress in informal family caregivers of community dwelling adults with chronic disorders in Thailand

Grant Number:

4R33MH131043-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

7/31/2028

Project Abstract

Project Summary In lower-and-middle income countries (LMICs) like Thailand, family members providing care for adults with chronic disorders experience similar levels of mental health risks to that of their counterparts in higher income countries but have significantly more limited access to mental ...

Research Terms

<21+ years old><Activities of Daily Living><Activities of everyday life><Adult><Adult Human><Anxiety><Behavioral><Care Givers><Care giver intervention><Caregivers><Caring><Chronic Disease><Chronic Illness><Clinical><Communities><Computer software><Country><Death Rate><Development><Diagnosis><Distress><Early Diagnosis><Early Intervention><Economic Income><Economical Income><Effectiveness><Emotional Depression><Employment><Ensure><Evidence based intervention><Family Care Giver><Family Caregiver><Family member><Financial Hardship><Frequencies><Goals><Health><Health Care Technology><Health Technology><Income><Individual><Institutionalization><Intervention><Interview><LMIC><Mental Depression><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Mental disorders><Mental health disorders><Mobile Health App><Mobile Health Application><Outcome><Output><Participant><Patients><Persons><Phased Innovation Awards><Prevention><Privacy><Provider><Psychiatric Disease><Psychiatric Disorder><Psychologic Stress><Psychological Health><Psychological Stress><Qualitative Research><R21/R33 Mechanism><R21/R33 Program><Reporting><Research><Risk><Self Care><Self Efficacy><Software><Technology><Testing><Thailand><Training><Western World><adulthood><adverse consequence><adverse outcome><app based delivery><app delivery><app-delivered><assess effectiveness><burn-out><burnout><care giving><care receiver><care recipients><care seeking><caregiver interventions><caregiving><chronic disorder><compare to control><comparison control><coping mechanism><daily living function><daily living functionality><depression><depression symptom><depressive><depressive symptoms><design><designing><determine effectiveness><developmental><digital health><digital mental health><e-Health><eHealth><early detection><effectiveness assessment><effectiveness evaluation><electronic health><evaluate effectiveness><evidence base><examine effectiveness><experience><experimental arm><fall risk><financial adversity><financial burden><financial distress><financial insecurity><financial strain><financial stress><formative assessment><formative evaluation><functional ability><functional capacity><health and care delivery><health care delivery><health delivery systems><health services delivery><improved><incomes><innovate><innovation><innovative><literacy><low and middle-income countries><m-Health><m-Health app><m-Health application><mHealth><mHealth app><mHealth application><mental health care><mental illness><mobile app><mobile application><mobile application delivered><mobile application delivery><mobile computing><mobile device application><mobile health><mobile platform><mobile technology><mortality rate><mortality ratio><personal care><prevent><preventing><programs><psychiatric illness><psychological disorder><psychological distress><randomized, clinical trials><routine care><social cultural factor><social culture><social culture determinant><social stigma><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><stigma><stressor><success><technology intervention><technology-based interventions><technology-enabled interventions><technology-focused interventions><usability>
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SUE E LEVKOFF

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Active award
$173,865
FY 2025

Project Title

Mobile application for early detection and intervention to reduce psychological distress in informal family caregivers of community dwelling adults with chronic disorders in Thailand

Grant Number:

4R33MH131043-03

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

7/31/2028

Project Abstract

Project Summary In lower-and-middle income countries (LMICs) like Thailand, family members providing care for adults with chronic disorders experience similar levels of mental health risks to that of their counterparts in higher income countries but have significantly more limited access to mental ...

Research Terms

<21+ years old><Activities of Daily Living><Activities of everyday life><Adult><Adult Human><Anxiety><Behavioral><Care Givers><Care giver intervention><Caregivers><Caring><Chronic Disease><Chronic Illness><Clinical><Communities><Computer software><Country><Death Rate><Development><Diagnosis><Distress><Early Diagnosis><Early Intervention><Economic Income><Economical Income><Effectiveness><Emotional Depression><Employment><Ensure><Evidence based intervention><Family Care Giver><Family Caregiver><Family member><Financial Hardship><Frequencies><Goals><Health><Health Care Technology><Health Technology><Income><Individual><Institutionalization><Intervention><Interview><LMIC><Mental Depression><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Mental disorders><Mental health disorders><Mobile Health App><Mobile Health Application><Outcome><Output><Participant><Patients><Persons><Phased Innovation Awards><Prevention><Privacy><Provider><Psychiatric Disease><Psychiatric Disorder><Psychologic Stress><Psychological Health><Psychological Stress><Qualitative Research><R21/R33 Mechanism><R21/R33 Program><Reporting><Research><Risk><Self Care><Self Efficacy><Software><Technology><Testing><Thailand><Training><Western World><adulthood><adverse consequence><adverse outcome><app based delivery><app delivery><app-delivered><assess effectiveness><burn-out><burnout><care giving><care receiver><care recipients><care seeking><caregiver interventions><caregiving><chronic disorder><compare to control><comparison control><coping mechanism><daily living function><daily living functionality><depression><depression symptom><depressive><depressive symptoms><design><designing><determine effectiveness><developmental><digital health><digital mental health><e-Health><eHealth><early detection><effectiveness assessment><effectiveness evaluation><electronic health><evaluate effectiveness><evidence base><examine effectiveness><experience><experimental arm><fall risk><financial adversity><financial burden><financial distress><financial insecurity><financial strain><financial stress><formative assessment><formative evaluation><functional ability><functional capacity><health and care delivery><health care delivery><health delivery systems><health services delivery><improved><incomes><innovate><innovation><innovative><literacy><low and middle-income countries><m-Health><m-Health app><m-Health application><mHealth><mHealth app><mHealth application><mental health care><mental illness><mobile app><mobile application><mobile application delivered><mobile application delivery><mobile computing><mobile device application><mobile health><mobile platform><mobile technology><mortality rate><mortality ratio><personal care><prevent><preventing><programs><psychiatric illness><psychological disorder><psychological distress><randomized, clinical trials><routine care><social cultural factor><social culture><social culture determinant><social stigma><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><stigma><stressor><success><technology intervention><technology-based interventions><technology-enabled interventions><technology-focused interventions><usability>
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Lawrence J. BONASSAR

CORNELL UNIVERSITY, ITHACA, NY

Exploratory lead · 10/100
Active award
$153,694
FY 2025

Project Title

Using STRAINS, a big data method that analyzes the spatiotemporal distribution of cell phenotypes, to investigate mechanotransduction pathways in injured cartilage

Grant Number:

5R21AR083064-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/5/2024

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY Osteoarthritis is a leading cause of disability in the US affecting almost 30 million people at an annual cost of $128 billion. Initiation of osteoarthritis is tied to genetic predisposition, chronic overload, or acute injury due to joint trauma. The development of osteoarthritis aft...

Research Terms

<Acute><Affect><Animal Model><Animal Models and Related Studies><Apoptosis><Apoptosis Pathway><Behavior><Big Data><Big Data Analytics><Big Data Methods><Big Data Tools><BigData><Bioenergetics><Body Tissues><Buffers><Calcium><Calcium Ion Signaling><Calcium Signaling><Cartilage><Cartilage injury><Cartilaginous Tissue><Cell Body><Cell Communication and Signaling><Cell Death><Cell Membrane Permeability><Cell Signaling><Cells><Cellular Mechanotransduction><Cellular injury><Chondrocytes><Chronic><Clinical><Complex><Data><Data Analyses><Data Analysis><Degenerative Arthritis><Degenerative polyarthritis><Development><Disease><Disorder><Dysfunction><Event><Exhibits><Exploratory/Developmental Grant><Exposure to><Frequencies><Functional disorder><Future><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Goals><Heterogeneity><Image Analyses><Image Analysis><In Situ><Individual><Inherited Predisposition><Inherited Susceptibility><Injury><Intervention><Intracellular Communication and Signaling><Ion Channel><Ionic Channels><Location><Machine Learning><Maps><Measurement><Measures><Mechanical Signal Transduction><Mechanics><Mechanosensory Transduction><Membrane Channels><Methods><Microscopy><Mitochondria><Modeling><Modification><Msec><Nuclear><Nuclear Envelope><Nuclear Membrane><Osteoarthritis><Osteoarthrosis><Pain><Painful><Pathogenesis><Pathway interactions><Pattern><Peptides><Permeability><Persons><Phenotype><Physiologic><Physiological><Physiopathology><Piezo 1><Piezo 1 ion channel><Piezo1><Play><Population><Process><Production><Programmed Cell Death><R21 Mechanism><R21 Program><Reaction Time><Research><Response RT><Response Time><Role><Secondary to><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Spatial Distribution><Staining method><Stains><Stress><Structure><Techniques><Time><Tissues><Trauma><Traumatic Arthritis><Traumatic Arthropathy><Traumatic injury><United States><Variant><Variation><Work><acute stress><articular cartilage><biological signal transduction><cartilage cell><cell behavior><cell damage><cell injury><cellular behavior><cellular damage><cost><damage to cells><data interpretation><degenerative joint disease><developmental><disability><effective therapy><effective treatment><elastic imaging><elasticity imaging><elastography><experience><exploratory developmental study><fluorescence imaging><fluorescent imaging><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><hypertrophic arthritis><image evaluation><image interpretation><improved><in vivo><inhibitor><injuries><injury to cells><injury to tissue><insight><intra-vital imaging><intravital imaging><joint damage><joint injury><joint trauma><machine based learning><mechanic><mechanical><mechanosensing><mechanotransduction><membrane permeability><millisecond><mitochondrial><model of animal><necrocytosis><novel><pathophysiology><pathway><population based><post-traumatic osteoarthritis><prevent><preventing><psychomotor reaction time><response><single cell analysis><social role><spatial and temporal><spatial temporal><spatial temporal imaging><spatial temporal mapping><spatiotemporal><spatiotemporal imaging><spatiotemporal mapping><supervised learning><supervised machine learning><temporal measurement><temporal resolution><time measurement><tissue injury><tool>
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Itai Cohen

CORNELL UNIVERSITY, ITHACA, NY

Exploratory lead · 10/100
Active award
$153,694
FY 2025

Project Title

Using STRAINS, a big data method that analyzes the spatiotemporal distribution of cell phenotypes, to investigate mechanotransduction pathways in injured cartilage

Grant Number:

5R21AR083064-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/5/2024

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY Osteoarthritis is a leading cause of disability in the US affecting almost 30 million people at an annual cost of $128 billion. Initiation of osteoarthritis is tied to genetic predisposition, chronic overload, or acute injury due to joint trauma. The development of osteoarthritis aft...

Research Terms

<Acute><Affect><Animal Model><Animal Models and Related Studies><Apoptosis><Apoptosis Pathway><Behavior><Big Data><Big Data Analytics><Big Data Methods><Big Data Tools><BigData><Bioenergetics><Body Tissues><Buffers><Calcium><Calcium Ion Signaling><Calcium Signaling><Cartilage><Cartilage injury><Cartilaginous Tissue><Cell Body><Cell Communication and Signaling><Cell Death><Cell Membrane Permeability><Cell Signaling><Cells><Cellular Mechanotransduction><Cellular injury><Chondrocytes><Chronic><Clinical><Complex><Data><Data Analyses><Data Analysis><Degenerative Arthritis><Degenerative polyarthritis><Development><Disease><Disorder><Dysfunction><Event><Exhibits><Exploratory/Developmental Grant><Exposure to><Frequencies><Functional disorder><Future><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Goals><Heterogeneity><Image Analyses><Image Analysis><In Situ><Individual><Inherited Predisposition><Inherited Susceptibility><Injury><Intervention><Intracellular Communication and Signaling><Ion Channel><Ionic Channels><Location><Machine Learning><Maps><Measurement><Measures><Mechanical Signal Transduction><Mechanics><Mechanosensory Transduction><Membrane Channels><Methods><Microscopy><Mitochondria><Modeling><Modification><Msec><Nuclear><Nuclear Envelope><Nuclear Membrane><Osteoarthritis><Osteoarthrosis><Pain><Painful><Pathogenesis><Pathway interactions><Pattern><Peptides><Permeability><Persons><Phenotype><Physiologic><Physiological><Physiopathology><Piezo 1><Piezo 1 ion channel><Piezo1><Play><Population><Process><Production><Programmed Cell Death><R21 Mechanism><R21 Program><Reaction Time><Research><Response RT><Response Time><Role><Secondary to><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Spatial Distribution><Staining method><Stains><Stress><Structure><Techniques><Time><Tissues><Trauma><Traumatic Arthritis><Traumatic Arthropathy><Traumatic injury><United States><Variant><Variation><Work><acute stress><articular cartilage><biological signal transduction><cartilage cell><cell behavior><cell damage><cell injury><cellular behavior><cellular damage><cost><damage to cells><data interpretation><degenerative joint disease><developmental><disability><effective therapy><effective treatment><elastic imaging><elasticity imaging><elastography><experience><exploratory developmental study><fluorescence imaging><fluorescent imaging><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><hypertrophic arthritis><image evaluation><image interpretation><improved><in vivo><inhibitor><injuries><injury to cells><injury to tissue><insight><intra-vital imaging><intravital imaging><joint damage><joint injury><joint trauma><machine based learning><mechanic><mechanical><mechanosensing><mechanotransduction><membrane permeability><millisecond><mitochondrial><model of animal><necrocytosis><novel><pathophysiology><pathway><population based><post-traumatic osteoarthritis><prevent><preventing><psychomotor reaction time><response><single cell analysis><social role><spatial and temporal><spatial temporal><spatial temporal imaging><spatial temporal mapping><spatiotemporal><spatiotemporal imaging><spatiotemporal mapping><supervised learning><supervised machine learning><temporal measurement><temporal resolution><time measurement><tissue injury><tool>
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Michelle Lee Delco

CORNELL UNIVERSITY, ITHACA, NY

Exploratory lead · 10/100
Active award
$153,694
FY 2025

Project Title

Using STRAINS, a big data method that analyzes the spatiotemporal distribution of cell phenotypes, to investigate mechanotransduction pathways in injured cartilage

Grant Number:

5R21AR083064-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/5/2024

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY Osteoarthritis is a leading cause of disability in the US affecting almost 30 million people at an annual cost of $128 billion. Initiation of osteoarthritis is tied to genetic predisposition, chronic overload, or acute injury due to joint trauma. The development of osteoarthritis aft...

Research Terms

<Acute><Affect><Animal Model><Animal Models and Related Studies><Apoptosis><Apoptosis Pathway><Behavior><Big Data><Big Data Analytics><Big Data Methods><Big Data Tools><BigData><Bioenergetics><Body Tissues><Buffers><Calcium><Calcium Ion Signaling><Calcium Signaling><Cartilage><Cartilage injury><Cartilaginous Tissue><Cell Body><Cell Communication and Signaling><Cell Death><Cell Membrane Permeability><Cell Signaling><Cells><Cellular Mechanotransduction><Cellular injury><Chondrocytes><Chronic><Clinical><Complex><Data><Data Analyses><Data Analysis><Degenerative Arthritis><Degenerative polyarthritis><Development><Disease><Disorder><Dysfunction><Event><Exhibits><Exploratory/Developmental Grant><Exposure to><Frequencies><Functional disorder><Future><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Goals><Heterogeneity><Image Analyses><Image Analysis><In Situ><Individual><Inherited Predisposition><Inherited Susceptibility><Injury><Intervention><Intracellular Communication and Signaling><Ion Channel><Ionic Channels><Location><Machine Learning><Maps><Measurement><Measures><Mechanical Signal Transduction><Mechanics><Mechanosensory Transduction><Membrane Channels><Methods><Microscopy><Mitochondria><Modeling><Modification><Msec><Nuclear><Nuclear Envelope><Nuclear Membrane><Osteoarthritis><Osteoarthrosis><Pain><Painful><Pathogenesis><Pathway interactions><Pattern><Peptides><Permeability><Persons><Phenotype><Physiologic><Physiological><Physiopathology><Piezo 1><Piezo 1 ion channel><Piezo1><Play><Population><Process><Production><Programmed Cell Death><R21 Mechanism><R21 Program><Reaction Time><Research><Response RT><Response Time><Role><Secondary to><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Spatial Distribution><Staining method><Stains><Stress><Structure><Techniques><Time><Tissues><Trauma><Traumatic Arthritis><Traumatic Arthropathy><Traumatic injury><United States><Variant><Variation><Work><acute stress><articular cartilage><biological signal transduction><cartilage cell><cell behavior><cell damage><cell injury><cellular behavior><cellular damage><cost><damage to cells><data interpretation><degenerative joint disease><developmental><disability><effective therapy><effective treatment><elastic imaging><elasticity imaging><elastography><experience><exploratory developmental study><fluorescence imaging><fluorescent imaging><genetic etiology><genetic mechanism of disease><genetic vulnerability><genetically predisposed><hypertrophic arthritis><image evaluation><image interpretation><improved><in vivo><inhibitor><injuries><injury to cells><injury to tissue><insight><intra-vital imaging><intravital imaging><joint damage><joint injury><joint trauma><machine based learning><mechanic><mechanical><mechanosensing><mechanotransduction><membrane permeability><millisecond><mitochondrial><model of animal><necrocytosis><novel><pathophysiology><pathway><population based><post-traumatic osteoarthritis><prevent><preventing><psychomotor reaction time><response><single cell analysis><social role><spatial and temporal><spatial temporal><spatial temporal imaging><spatial temporal mapping><spatiotemporal><spatiotemporal imaging><spatiotemporal mapping><supervised learning><supervised machine learning><temporal measurement><temporal resolution><time measurement><tissue injury><tool>
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Calliope Holingue

HUGO W. MOSER RES INST KENNEDY KRIEGER, BALTIMORE, MD

Exploratory lead · 10/100
Active award
$147,501
FY 2025

Project Title

Development and Psychometric Evaluation of Gastrointestinal Symptom Measures in Autistic Children and Adults

Grant Number:

5R21HD111609-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/12/2024

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT Gastrointestinal (GI) symptoms appear to be common and disabling in children and adults on the autism spectrum. Co-occurring GI symptoms are associated with physical, mental, and behavioral health issues, and lower quality of life. Yet, autistic children and adults face impo...

Research Terms

<0-11 years old><21+ years old><3 year old><3 years of age><ASD><Abdominal Pain><Acid Reflux><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Age><Autism><Autism Diagnosis><Autistic Disorder><Behavior><Behavioral Symptoms><Biometrics><Biometry><Biostatistics><Care Givers><Caregivers><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical><Clinical Data><Clinical Treatment><Communication challenge><Communication difficulty><Communities><Community Networks><Constipation><Data><Development><Device or Instrument Development><Diagnosis><Diarrhea><Dietary Practices><Dimensions><Disabling><Distress><Dysfunction><Early Infantile Autism><Ensure><Epidemiology><Equipment and supply inventories><Esophageal Reflux><Ethnic Origin><Ethnicity><Evaluation><Exploratory/Developmental Grant><Face><Foundations><Functional disorder><GERD><Gastro-oesophageal Reflux><Gastroenterology><Gastroesophageal Reflux><Gastroesophageal reflux disease><Gastrointestinal Diseases><Goals><Guidelines><Health><Individual><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intervention Trial><Interventional trial><Inventory><Kanner's Syndrome><Language><Link><Literature><Lived experience><Lived experiences><Measurement><Measures><Mental Health><Mental Hygiene><NIH><National Institutes of Health><Neuropsychologies><Neuropsychology><Parents><Participant><Patient Recruitments><Patient Self-Report><Performance><Personal Satisfaction><Persons><Physiopathology><Population><Position><Positioning Attribute><Psychological Health><Psychometrics><QOL><Quality of life><Questionnaires><R21 Mechanism><R21 Program><Race><Races><Reporting><Research><Research Institute><Research Resources><Resources><Sampling><Self-Report><Structure><Subgroup><Symptoms><Testing><United States National Institutes of Health><Validation><Work><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><age 3 years><ages><assess effectiveness><associated symptom><autism spectral disorder><autism spectrum disorder><autistic><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><behavioral health><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical intervention><clinical therapy><co-morbid symptom><co-occuring symptom><cognitive disability><cognitive interview><cognitively disabled><common symptom><comorbid symptom><concurrent symptom><cooccuring symptom><design><designing><determine effectiveness><developmental><device development><dietary pattern><effectiveness assessment><effectiveness clinical trial><effectiveness evaluation><epidemiologic><epidemiological><evaluate effectiveness><examine effectiveness><experience><exploratory developmental study><faces><facial><gastrointestinal><gastrointestinal disorder><gastrointestinal sign><gastrointestinal symptom><improved><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><instrument development><intellectual and developmental disability><juvenile><juvenile human><kids><limited intellectual functioning><minimally speaking><minimally verbal><neuropsychologic><non-speaking><non-verbal><non-vocal><novel><on-line community><online community><parent><participant recruitment><pathophysiology><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><physical conditioning><physical health><racial><racial background><racial origin><recruit><research study><safety assessment><screen time><sex><sound><symptom association><symptom comorbidity><television watching><three year old><three years of age><time use><tool><trial regimen><trial treatment><tv watching><validations><virtual community><well-being><wellbeing><youngster>
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Ross Mathew Boyce

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 10/100
Active award
$123,118
FY 2025

Project Title

Reducing malaria in pregnancy through focal drug administration in household members: A pilot feasibility trial

Grant Number:

3R21AI180728-02S1

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2025

End Date:

5/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Malaria in pregnancy (MiP) carries substantial - but largely preventable - risks for both the pregnant woman and unborn child. Despite rigorous evidence supporting the efficacy of current interventions, such as long-lasting insecticidal nets (LLIN) and intermittent preventiv...

Research Terms

<0-11 years old><Access to Care><Adherence><Adverse Experience><Adverse event><Africa South of the Sahara><Anti-malarials><Area><Artemisinins><Breeding><Case Management><Child><Child Youth><Children (0-21)><Clinic><Clinic Visits><Clinical><Combined Modality Therapy><Complement><Complement Proteins><Country><Daraprim><Data><Data Collection><Diagnostic tests><Disease><Disorder><Dose><Drug resistance><Drugs><Effectiveness><Endemic Diseases><Exploratory/Developmental Grant><Fever><Frequencies><Gestation><Guidelines><Health Services Accessibility><Home environment><Household><Incidence><Infection><Injectable><Insecticide Resistance><Insecticides><Intervention><Lethargies><Live Birth><Low Birth Weight Infant><Malaria><Malaria prevention><Measures><Medication><Morbidity><Morbidity - disease rate><Multimodal Therapy><Multimodal Treatment><NIAID><National Institute of Allergy and Infectious Disease><Outcome Study><P falciparum><P. falciparum><P.falciparum><Paludism><Parasitemia><Parasites><Pharmaceutical Preparations><Phase><Pilot Projects><Plasmodium Infections><Plasmodium falciparum><Pregnancy><Pregnant Women><Prevalence><Preventative therapy><Preventative treatment><Preventive therapy><Preventive treatment><Process Assessment><Process Measure><Protocol><Protocols documentation><Pyrexia><Pyrimethamine><R21 Mechanism><R21 Program><Randomized><Randomized, Controlled Trials><Rapid diagnostics><Recommendation><Regimen><Reporting><Research><Research Design><Residual><Residual state><Risk><Risk Reduction><Rural><Safety><Site><Study Type><Sub-Saharan Africa><Subsaharan Africa><Sulfadoxine><Sulfadoxine-pyrimethamine (SP) resistance><Sulfadoxine-pyrimethamine (SP) resistant><Sulfadoxine-pyrimethamine resistance><Sulfadoxine-pyrimethamine resistant><Sulformethoxine><Sulformetoxine><Sulforthomidine><Sulphormetoxin><Symptoms><Technical Expertise><Testing><Time><Treatment Efficacy><Uganda><Vaccines><Visit><Vulnerable Populations><Woman><acceptability and feasibility><access to health services><access to services><access to treatment><accessibility to health services><adverse birth outcomes><antenatal><antepartum><anti-malarial agents><anti-malarial drugs><arteannuin><artemisinine><availability of services><care access><care as usual><combination therapy><combined modality treatment><combined treatment><complementation><drug resistant><drug/agent><effective therapy><effective treatment><expectant mother><expectant women><expecting mother><expecting women><exploratory developmental study><feasibility trial><febrile><febris><health service access><health services availability><implementation framework><implementation research framework><implementation science framework><individuals who are pregnant><innovate><innovation><innovative><insecticide resistant><instrument><intervention cost><intervention efficacy><kids><low birth weight><low birthweight><malaria transmission><member><mortality><multi-modal therapy><multi-modal treatment><novel><open label><open label study><parasaetemia><people who are pregnant><pilot study><placebo control trial><placebo controlled trial><placental malaria><pregnancy prevention><pregnant females><pregnant mothers><pregnant people><pregnant populations><prevent><prevent malaria><preventing><prevention of pregnancy><primary care health center><primary health center><programs><prophylactic><qinghaosu><quing hau sau><quinghaosu><randomisation><randomization><randomized control trial><randomly assigned><recruit><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resistance to Drug><resistance to Sulfadoxine-pyrimethamine><resistant to Drug><resistant to Sulfadoxine-pyrimethamine><retention rate><retention strategy><risk-reducing><service availability><spatial and temporal><spatial temporal><spatiotemporal><stillbirth><stillborn><study design><technical skills><theories><therapeutic efficacy><therapy efficacy><those who are pregnant><tool><treatment access><treatment as usual><unborn child><uptake><usual care><vector control><vulnerable group><vulnerable individual><vulnerable people><willingness><women who are pregnant><youngster>
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Hongtu Chen

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Active award
$108,000
FY 2025

Project Title

Mobile application for early detection and intervention to reduce psychological distress in informal family caregivers of community dwelling adults with chronic disorders in Thailand

Grant Number:

3R33MH131043-03S1

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

7/31/2028

Project Abstract

Project Summary In lower-and-middle income countries (LMICs) like Thailand, family members providing care for adults with chronic disorders experience similar levels of mental health risks to that of their counterparts in higher income countries but have significantly more limited access to mental ...

Research Terms

<21+ years old><Activities of Daily Living><Activities of everyday life><Adult><Adult Human><Anxiety><Behavioral><Care Givers><Care giver intervention><Caregivers><Caring><Chronic Disease><Chronic Illness><Clinical><Communities><Computer software><Country><Death Rate><Development><Diagnosis><Distress><Early Diagnosis><Early Intervention><Economic Income><Economical Income><Effectiveness><Emotional Depression><Employment><Ensure><Evidence based intervention><Family Care Giver><Family Caregiver><Family member><Financial Hardship><Frequencies><Goals><Health><Health Care Technology><Health Technology><Income><Individual><Institutionalization><Intervention><Interview><LMIC><Mental Depression><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Mental disorders><Mental health disorders><Mobile Health App><Mobile Health Application><Outcome><Output><Participant><Patients><Persons><Phased Innovation Awards><Prevention><Privacy><Provider><Psychiatric Disease><Psychiatric Disorder><Psychologic Stress><Psychological Health><Psychological Stress><Qualitative Research><R21/R33 Mechanism><R21/R33 Program><Reporting><Research><Risk><Self Care><Self Efficacy><Software><Technology><Testing><Thailand><Training><Western World><adulthood><adverse consequence><adverse outcome><app based delivery><app delivery><app-delivered><assess effectiveness><burn-out><burnout><care giving><care receiver><care recipients><care seeking><caregiver interventions><caregiving><chronic disorder><compare to control><comparison control><coping mechanism><daily living function><daily living functionality><depression><depression symptom><depressive><depressive symptoms><design><designing><determine effectiveness><developmental><digital health><digital mental health><e-Health><eHealth><early detection><effectiveness assessment><effectiveness evaluation><electronic health><evaluate effectiveness><evidence base><examine effectiveness><experience><experimental arm><fall risk><financial adversity><financial burden><financial distress><financial insecurity><financial strain><financial stress><formative assessment><formative evaluation><functional ability><functional capacity><health and care delivery><health care delivery><health delivery systems><health services delivery><improved><incomes><innovate><innovation><innovative><literacy><low and middle-income countries><m-Health><m-Health app><m-Health application><mHealth><mHealth app><mHealth application><mental health care><mental illness><mobile app><mobile application><mobile application delivered><mobile application delivery><mobile computing><mobile device application><mobile health><mobile platform><mobile technology><mortality rate><mortality ratio><personal care><prevent><preventing><programs><psychiatric illness><psychological disorder><psychological distress><randomized, clinical trials><routine care><social cultural factor><social culture><social culture determinant><social stigma><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><stigma><stressor><success><technology intervention><technology-based interventions><technology-enabled interventions><technology-focused interventions><usability>
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Komatra Chuengsatiansup

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Active award
$108,000
FY 2025

Project Title

Mobile application for early detection and intervention to reduce psychological distress in informal family caregivers of community dwelling adults with chronic disorders in Thailand

Grant Number:

3R33MH131043-03S1

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

7/31/2028

Project Abstract

Project Summary In lower-and-middle income countries (LMICs) like Thailand, family members providing care for adults with chronic disorders experience similar levels of mental health risks to that of their counterparts in higher income countries but have significantly more limited access to mental ...

Research Terms

<21+ years old><Activities of Daily Living><Activities of everyday life><Adult><Adult Human><Anxiety><Behavioral><Care Givers><Care giver intervention><Caregivers><Caring><Chronic Disease><Chronic Illness><Clinical><Communities><Computer software><Country><Death Rate><Development><Diagnosis><Distress><Early Diagnosis><Early Intervention><Economic Income><Economical Income><Effectiveness><Emotional Depression><Employment><Ensure><Evidence based intervention><Family Care Giver><Family Caregiver><Family member><Financial Hardship><Frequencies><Goals><Health><Health Care Technology><Health Technology><Income><Individual><Institutionalization><Intervention><Interview><LMIC><Mental Depression><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Mental disorders><Mental health disorders><Mobile Health App><Mobile Health Application><Outcome><Output><Participant><Patients><Persons><Phased Innovation Awards><Prevention><Privacy><Provider><Psychiatric Disease><Psychiatric Disorder><Psychologic Stress><Psychological Health><Psychological Stress><Qualitative Research><R21/R33 Mechanism><R21/R33 Program><Reporting><Research><Risk><Self Care><Self Efficacy><Software><Technology><Testing><Thailand><Training><Western World><adulthood><adverse consequence><adverse outcome><app based delivery><app delivery><app-delivered><assess effectiveness><burn-out><burnout><care giving><care receiver><care recipients><care seeking><caregiver interventions><caregiving><chronic disorder><compare to control><comparison control><coping mechanism><daily living function><daily living functionality><depression><depression symptom><depressive><depressive symptoms><design><designing><determine effectiveness><developmental><digital health><digital mental health><e-Health><eHealth><early detection><effectiveness assessment><effectiveness evaluation><electronic health><evaluate effectiveness><evidence base><examine effectiveness><experience><experimental arm><fall risk><financial adversity><financial burden><financial distress><financial insecurity><financial strain><financial stress><formative assessment><formative evaluation><functional ability><functional capacity><health and care delivery><health care delivery><health delivery systems><health services delivery><improved><incomes><innovate><innovation><innovative><literacy><low and middle-income countries><m-Health><m-Health app><m-Health application><mHealth><mHealth app><mHealth application><mental health care><mental illness><mobile app><mobile application><mobile application delivered><mobile application delivery><mobile computing><mobile device application><mobile health><mobile platform><mobile technology><mortality rate><mortality ratio><personal care><prevent><preventing><programs><psychiatric illness><psychological disorder><psychological distress><randomized, clinical trials><routine care><social cultural factor><social culture><social culture determinant><social stigma><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><stigma><stressor><success><technology intervention><technology-based interventions><technology-enabled interventions><technology-focused interventions><usability>
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SUE E LEVKOFF

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Active award
$108,000
FY 2025

Project Title

Mobile application for early detection and intervention to reduce psychological distress in informal family caregivers of community dwelling adults with chronic disorders in Thailand

Grant Number:

3R33MH131043-03S1

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

7/31/2028

Project Abstract

Project Summary In lower-and-middle income countries (LMICs) like Thailand, family members providing care for adults with chronic disorders experience similar levels of mental health risks to that of their counterparts in higher income countries but have significantly more limited access to mental ...

Research Terms

<21+ years old><Activities of Daily Living><Activities of everyday life><Adult><Adult Human><Anxiety><Behavioral><Care Givers><Care giver intervention><Caregivers><Caring><Chronic Disease><Chronic Illness><Clinical><Communities><Computer software><Country><Death Rate><Development><Diagnosis><Distress><Early Diagnosis><Early Intervention><Economic Income><Economical Income><Effectiveness><Emotional Depression><Employment><Ensure><Evidence based intervention><Family Care Giver><Family Caregiver><Family member><Financial Hardship><Frequencies><Goals><Health><Health Care Technology><Health Technology><Income><Individual><Institutionalization><Intervention><Interview><LMIC><Mental Depression><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Mental disorders><Mental health disorders><Mobile Health App><Mobile Health Application><Outcome><Output><Participant><Patients><Persons><Phased Innovation Awards><Prevention><Privacy><Provider><Psychiatric Disease><Psychiatric Disorder><Psychologic Stress><Psychological Health><Psychological Stress><Qualitative Research><R21/R33 Mechanism><R21/R33 Program><Reporting><Research><Risk><Self Care><Self Efficacy><Software><Technology><Testing><Thailand><Training><Western World><adulthood><adverse consequence><adverse outcome><app based delivery><app delivery><app-delivered><assess effectiveness><burn-out><burnout><care giving><care receiver><care recipients><care seeking><caregiver interventions><caregiving><chronic disorder><compare to control><comparison control><coping mechanism><daily living function><daily living functionality><depression><depression symptom><depressive><depressive symptoms><design><designing><determine effectiveness><developmental><digital health><digital mental health><e-Health><eHealth><early detection><effectiveness assessment><effectiveness evaluation><electronic health><evaluate effectiveness><evidence base><examine effectiveness><experience><experimental arm><fall risk><financial adversity><financial burden><financial distress><financial insecurity><financial strain><financial stress><formative assessment><formative evaluation><functional ability><functional capacity><health and care delivery><health care delivery><health delivery systems><health services delivery><improved><incomes><innovate><innovation><innovative><literacy><low and middle-income countries><m-Health><m-Health app><m-Health application><mHealth><mHealth app><mHealth application><mental health care><mental illness><mobile app><mobile application><mobile application delivered><mobile application delivery><mobile computing><mobile device application><mobile health><mobile platform><mobile technology><mortality rate><mortality ratio><personal care><prevent><preventing><programs><psychiatric illness><psychological disorder><psychological distress><randomized, clinical trials><routine care><social cultural factor><social culture><social culture determinant><social stigma><socio-cultural><sociocultural><sociocultural determinant><sociocultural factor><stigma><stressor><success><technology intervention><technology-based interventions><technology-enabled interventions><technology-focused interventions><usability>
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Aimalohi Ahonkhai

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Active award
$97,335
FY 2025

Project Title

An interactive, narrative intervention to address the mental health treatment gap among young people living with HIV in Nigeria

Grant Number:

3R33HD106578-06S1

Activity Code:

R33

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/8/2024

End Date:

6/30/2026

Project Abstract

PROJECT SUMMARY Young people living with HIV (Y-PLWH) have poor adherence to antiretroviral therapy and engagement in HIV care, making HIV the leading cause of death for African adolescents. Depression and psychological distress are much more common among Y-PLWH than in the general population, and a...

Research Terms

<AIDS Virus><Access to Care><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adherence><Adolescent><Adolescent Youth><Adopted><Africa><Africa South of the Sahara><African><Appointment><COVID-19><CV-19><Care Givers><Caregivers><Caring><Cause of Death><Cell Phone><Cellular Phone><Cellular Telephone><Climate><Clinic><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Coronavirus Infectious Disease 2019><Country><Development><Diagnosis><Disease remission><Distress><Effectiveness><Emotional><Epidemiology><Exploratory/Developmental Grant><Friends><Funding Opportunities><Future><General Population><General Public><Goals><HIV><Health><Health Care Professional><Health Care Technology><Health Professional><Health Promotion><Health Services Accessibility><Health Technology><Home><Human Immunodeficiency Viruses><Individual><Interdisciplinary Research><Interdisciplinary Study><Intervention><Investigators><Knowledge><LAV-HTLV-III><LMIC><Lymphadenopathy-Associated Virus><Mental Depression><Mental Health><Mental Health Services><Mental Hygiene><Mental Hygiene Services><Mental disorders><Mental health disorders><Meteorological Climate><Mobile Phones><Multidisciplinary Collaboration><Multidisciplinary Research><Nigeria><Non-Profit Organizations><Nonprofit Organizations><Outcome><Ownership><Patients><Persons><Play><Population><Provider><Psychiatric Disease><Psychiatric Disorder><Psychiatric Social Service><Psychiatric Social Work><Psychological Health><Psychotherapy><Public Health><R21 Mechanism><R21 Program><Randomized, Controlled Trials><Recommendation><Remission><Research><Research Personnel><Researchers><Role><Salutogenesis><Side><Social Impacts><Sub-Saharan Africa><Subsaharan Africa><Technology><Testing><Therapeutic Intervention><Training><Treatment outcome><Universities><Virus-HIV><Visit><World Health Organization><Youth><Youth 10-21><acceptability and feasibility><access to health services><access to services><access to treatment><accessibility to health services><age group><antiretroviral therapy><antiretroviral treatment><availability of services><barriers to implementation><care access><care providers><climatic><co-morbid><co-morbidity><comorbidity><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><cost><depression><design><designing><developmental><digital><disease control><disorder control><drug adherence><drug compliance><effectiveness-implementation RCT><effectiveness-implementation randomized control trial><effectiveness-implementation randomized controlled trial><effectiveness/implementation hybrid><epidemic containment><epidemic control><epidemic mitigation><epidemic response><epidemiologic><epidemiological><evidence base><experience><exploratory developmental study><handheld mobile device><health service access><health services availability><homes><iPhone><implementation barriers><implementation challenges><implementation science><improved><innovate><innovation><innovative><interest><intervention delivery><intervention therapy><juvenile><juvenile human><low and middle-income countries><m-Health><mHealth><medication adherence><medication compliance><mental health care><mental illness><mental training><mobile device><mobile health><multidisciplinary><novel><problem solving therapy><promoting health><prototype><psychiatric illness><psychologic><psychological><psychological disorder><psychological distress><psychosocial service><randomized control trial><satisfaction><screening><screenings><service availability><smart phone><smartphone><social cognitive theory><social learning theory><social role><social stigma><stakeholder insights><stakeholder perspectives><stigma><telephone based><theories><treatment access><usability><virtual environment><youth age>
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Ross Mathew Boyce

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 10/100
Active award
$41,565
FY 2025

Project Title

Reducing malaria in pregnancy through focal drug administration in household members: A pilot feasibility trial

Grant Number:

5R21AI180728-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/19/2024

End Date:

5/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Malaria in pregnancy (MiP) carries substantial - but largely preventable - risks for both the pregnant woman and unborn child. Despite rigorous evidence supporting the efficacy of current interventions, such as long-lasting insecticidal nets (LLIN) and intermittent preventiv...

Research Terms

<0-11 years old><Access to Care><Adherence><Adverse Experience><Adverse event><Africa South of the Sahara><Anti-malarials><Area><Artemisinins><Breeding><Case Management><Child><Child Youth><Children (0-21)><Clinic><Clinic Visits><Clinical><Combined Modality Therapy><Complement><Complement Proteins><Country><Daraprim><Data><Data Collection><Diagnostic tests><Disease><Disorder><Dose><Drug resistance><Drugs><Effectiveness><Endemic Diseases><Exploratory/Developmental Grant><Fever><Frequencies><Gestation><Guidelines><Health Services Accessibility><Home environment><Household><Incidence><Infection><Injectable><Insecticide Resistance><Insecticides><Intervention><Lethargies><Live Birth><Low Birth Weight Infant><Malaria><Malaria prevention><Measures><Medication><Morbidity><Morbidity - disease rate><Multimodal Therapy><Multimodal Treatment><NIAID><National Institute of Allergy and Infectious Disease><Outcome Study><P falciparum><P. falciparum><P.falciparum><Paludism><Parasitemia><Parasites><Pharmaceutical Preparations><Phase><Pilot Projects><Plasmodium Infections><Plasmodium falciparum><Pregnancy><Pregnant Women><Prevalence><Preventative therapy><Preventative treatment><Preventive therapy><Preventive treatment><Process Assessment><Process Measure><Protocol><Protocols documentation><Pyrexia><Pyrimethamine><R21 Mechanism><R21 Program><Randomized><Randomized, Controlled Trials><Rapid diagnostics><Recommendation><Regimen><Reporting><Research><Research Design><Residual><Residual state><Risk><Risk Reduction><Rural><Safety><Site><Study Type><Sub-Saharan Africa><Subsaharan Africa><Sulfadoxine><Sulfadoxine-pyrimethamine (SP) resistance><Sulfadoxine-pyrimethamine (SP) resistant><Sulfadoxine-pyrimethamine resistance><Sulfadoxine-pyrimethamine resistant><Sulformethoxine><Sulformetoxine><Sulforthomidine><Sulphormetoxin><Symptoms><Technical Expertise><Testing><Time><Treatment Efficacy><Uganda><Vaccines><Visit><Vulnerable Populations><Woman><acceptability and feasibility><access to health services><access to services><access to treatment><accessibility to health services><adverse birth outcomes><antenatal><antepartum><anti-malarial agents><anti-malarial drugs><arteannuin><artemisinine><availability of services><care access><care as usual><combination therapy><combined modality treatment><combined treatment><complementation><drug resistant><drug/agent><effective therapy><effective treatment><expectant mother><expectant women><expecting mother><expecting women><exploratory developmental study><feasibility trial><febrile><febris><health service access><health services availability><implementation framework><implementation research framework><implementation science framework><individuals who are pregnant><innovate><innovation><innovative><insecticide resistant><instrument><intervention cost><intervention efficacy><kids><low birth weight><low birthweight><malaria transmission><member><mortality><multi-modal therapy><multi-modal treatment><novel><open label><open label study><parasaetemia><people who are pregnant><pilot study><placebo control trial><placebo controlled trial><placental malaria><pregnancy prevention><pregnant females><pregnant mothers><pregnant people><pregnant populations><prevent><prevent malaria><preventing><prevention of pregnancy><primary care health center><primary health center><programs><prophylactic><qinghaosu><quing hau sau><quinghaosu><randomisation><randomization><randomized control trial><randomly assigned><recruit><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><resistance to Drug><resistance to Sulfadoxine-pyrimethamine><resistant to Drug><resistant to Sulfadoxine-pyrimethamine><retention rate><retention strategy><risk-reducing><service availability><spatial and temporal><spatial temporal><spatiotemporal><stillbirth><stillborn><study design><technical skills><theories><therapeutic efficacy><therapy efficacy><those who are pregnant><tool><treatment access><treatment as usual><unborn child><uptake><usual care><vector control><vulnerable group><vulnerable individual><vulnerable people><willingness><women who are pregnant><youngster>
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Sathya Puthanveettil

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Exploratory lead · 0/100
$241,500
FY 2025

Project Title

Analysis of RNAs targeted to the long-distance projections of ventral hippocampus

Grant Number:

5R21MH133252-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/5/2023

End Date:

11/30/2025

Project Abstract

PROJECT SUMMARY In this R21 exploratory/developmental grant application, we propose to develop and validate methodologies for in vivo analysis of RNA targeting in specific circuits, as well as investigating the regulation of these RNAs during long-term memory storage (LTM). The significance of RNAs...

Research Terms

<Address><Affinity Chromatography><Ammon Horn><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Anatomic Sites><Anatomic structures><Anatomy><Animals><Aplysia><Applications Grants><Area><Axonal Transport><Axoplasmic Transport><Behavior Control><Behavioral Manipulation><Biology><Brain><Brain Nervous System><Cell Body><Cells><Circulatory Collapse><Clinical><Code><Coding System><Cognitive Retention Disorders><Common Rat Strains><Complex><Connector Neuron><Cornu Ammonis><Dendrites><Development><Distal><Dorsal><Encephalon><Exploratory/Developmental Grant><Failure><Family><Functional RNA><Glia><Glial Cells><Grant Proposals><Hippocampus><Hypothalamic structure><Hypothalamus><Immune Precipitation><Immunoprecipitation><Impairment><In vivo analysis><Individual><Intercalary Neuron><Intercalated Neurons><Interneurons><Internuncial Cell><Internuncial Neuron><Kinesin><Knowledge><Kolliker's reticulum><Learning><Maps><Medial><Mediating><Memory><Memory Disorders><Methodology><Mice><Mice Mammals><Microdissection><Modification><Molecular Analysis><Molecular Motors><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neuroglia><Neuroglial Cells><Neurons><Non-Polyadenylated RNA><Non-neuronal cell><Noncoding RNA><Nonneuronal cell><Nontranslated RNA><Nucleus Accumbens><Organism><Physiologic><Physiological><Play><Population><Prefrontal Cortex><Process><Proteins><R21 Mechanism><R21 Program><RNA><RNA Gene Products><RNA Seq><RNA Transport><RNA analysis><RNA sequencing><RNAseq><Rat><Rats Mammals><Rattus><Regulation><Reporting><Research><Ribonucleic Acid><Ribonucleic Acid Transport><Ribosomes><Role><Shock><Slice><Synapses><Synapsins><Synaptic><Target Populations><Testing><Translating><Translations><Untranslated RNA><Work><affinity purification><amygdaloid nuclear complex><behavioral control><circulatory shock><conditioned fear><developmental><experiment><experimental research><experimental study><experiments><exploratory developmental study><fear conditioning><fear memory><hippocampal><hypothalamic><in vivo><in vivo evaluation><in vivo testing><insight><knock-down><knockdown><laser capture microdissection><lentiviral-mediated><living system><long-term memory><nerve cement><neural circuit><neural circuitry><neurocircuitry><neuronal><noncoding><particle><postsynaptic><presynaptic><prevent><preventing><promoter><promotor><sea slug><shocks><social role><spatial memory><synapse><synaptic circuit><synaptic circuitry><transcriptome sequencing><transcriptomic sequencing><translation>
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Joseph Edgar Craft

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 0/100
$203,094
FY 2025

Project Title

Atypical B Cells: Origin and Autoreactivity

Grant Number:

5R21AI178097-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/19/2024

End Date:

11/30/2025

Project Abstract

PROJECT SUMMARY (ABSTRACT) Humoral immunity forms the basis for vaccine-induced immune protection. Following infection and vaccination, a fraction of activated B cells differentiates into long-lived plasma cells (LLPCs) or memory B cells to provide longitudinal protection against pathogens. Whereas ...

Research Terms

<Ab response><Address><Aging><Antibodies><Antibody Formation><Antibody Production><Antibody Response><Antigens><Autoantibodies><Autoimmune Diseases><Autoimmune Status><Autoimmunity><B blood cells><B cell><B cell differentiation><B cells><B lymphocyte differentiation><B-Cell Activation><B-Cell Subsets><B-Cells><B-Lymphocyte Subsets><B-Lymphocytes><B-cell><Bacterial Infections><Blood Plasma Cell><Blood Serum><Blood-Borne Pathogens><Bloodborne Pathogens><Body Tissues><Bone Marrow><Bone Marrow Reticuloendothelial System><CD11c><Cell Body><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Locomotion><Cell Migration><Cell Movement><Cell Signaling><Cells><Cellular Migration><Cellular Motility><Cellular biology><Circulation><DNA mutation><Development><Early Diagnosis><Equilibrium><Exhibits><Exploratory/Developmental Grant><Exposure to><Frequencies><Generations><Genetic Change><Genetic defect><Genetic mutation><Germ Lines><Goals><Human><Humoral Immunities><ITGAX><ITGAX gene><IgD><Immune><Immunes><Immunochemical Immunologic><Immunoglobulin D><Immunologic><Immunological><Immunologically><Immunologics><Infection><Infiltration><Influenza Vaccines><Intracellular Communication and Signaling><Invaded><Investigation><Knowledge><LCM Viruses><LCMV><Length of Life><Liver><Longevity><Lung><Lung Respiratory System><Lymphocytic choriomeningitis virus><Lymphoid><Mediating><Memory><Memory B Cell><Memory B-Lymphocyte><Mice><Mice Mammals><Microbe><Modern Man><Murine><Mus><Mutation><Nature><Organ><Pathogenicity><Pathology><Phenotype><Plasma Cells><Plasmacytes><Population><Population Heterogeneity><Position><Positioning Attribute><Prevalence><R21 Mechanism><R21 Program><Residencies><Role><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Site><Source><Specificity><Spleen><Spleen Reticuloendothelial System><Tissues><Vaccination><Vaccines><Viral><Viral Diseases><Virus><Virus Diseases><activated B cells><age associated><age correlated><age dependent><age linked><age related><age specific><antibody biosynthesis><antibody-based immunity><autoimmune antibody><autoimmune condition><autoimmune disorder><autoimmune reactivity><autoimmunity disease><autoreactive B cell><autoreactive antibody><autoreactivity><bacteria infection><bacterial disease><balance><balance function><biological signal transduction><cell biology><cell motility><cross reactivity><de novo mutation><de novo variant><develop a vaccine><develop vaccines><development of a vaccine><developmental><diverse populations><early detection><experience><exploratory developmental study><flu infection><flu vaccine><flu virus infection><flu virus vaccine><genome mutation><hepatic body system><hepatic organ system><heterogeneous population><immunogen><immunoglobulin biosynthesis><immunopathology><infected with flu><infected with flu virus><infected with influenza><infected with influenza virus><influenza infection><influenza virus infection><influenza virus vaccine><neutralizing antibody><novel><pathogen><plasmocyte><population diversity><response><self reactive B cell><self reactive antibody><social role><therapeutic target><vaccine against flu><vaccine against influenza><vaccine antibodies><vaccine development><vaccine induced antibodies><vaccine-induced antibodies><viral infection><virus infection><virus-induced disease>
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Daniel Alan Peterson

ROSALIND FRANKLIN UNIV OF MEDICINE & SCI, NORTH CHICAGO, IL

Exploratory lead · 0/100
$197,375
FY 2025

Project Title

Selective targeting of CNS cells in vivo for multiple transgene delivery and neuronal reprogramming

Grant Number:

5R21NS135301-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/20/2024

End Date:

3/31/2026

Project Abstract

Project Summary/Abstract Viral vectors enjoy widespread use for gene transfer to multiple cell types and organ systems in both research studies and, increasingly, in therapeutic strategies. For studies of the CNS, the ability of the viral vector to effectively and selectively infect the desired cell...

Research Terms

<21+ years old><Active Follow-up><Address><Adopted><Adult><Adult Human><Antigens><Astrocytes><Astrocytus><Astroglia><Automobile Driving><Aves><Avian><Binding><Birds><Body System><Brain><Brain Nervous System><CD140a Antigens><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Division Cycle><Cell Lineage><Cell Reprogramming><Cell Signaling><Cells><Characteristics><Chemicals><Clinical><DNA Therapy><Development><Disease><Disorder><Encephalon><Endothelial Cells><Experimental Therapies><Exploratory/Developmental Grant><Gene Delivery><Gene Expression><Gene Modified><Gene Transfer><Gene Transfer Clinical><Genes><Genetic Intervention><Infection><Instruction><Intracellular Communication and Signaling><Investigational Therapies><Investigational Treatments><Label><Lentivirinae><Lentivirus><Mammalian Cell><Membrane><Molecular Interaction><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurons><Optics><Organ System><Outcome Study><PDGF alpha Receptor><PDGF receptor α><PDGF-R-alpha><PDGFR-α><PDGFRα><Pathologic><Platelet-Derived Growth Factor Receptor Alpha Polypeptide><Platelet-Derived Growth Factor alpha Receptor><Play><Population><Predisposition><Progenitor Cells><Proliferating><R21 Mechanism><R21 Program><Rabies lyssavirus><Rabies virus><Receptor Protein><Reporter Genes><Reporting><Research><Retroviral Vector><Retrovirus Vector><Role><Signal Transduction><Signal Transduction Systems><Signaling><Specific qualifier value><Specificity><Specified><Suggestion><Susceptibility><Synapses><Synaptic><Therapeutic><Therapeutic Uses><Transcriptional Control><Transcriptional Regulation><Transgenes><Tropism><Tva protein><Tva receptor><Viral><Viral Vector><active followup><adulthood><astrocytic glia><biological signal transduction><cell type><cellular reprogramming><design><designing><developmental><driving><experiment><experimental research><experimental study><experimental therapeutic agents><experimental therapeutics><experiments><exploratory developmental study><follow up><follow-up><followed up><followup><gene modification><gene repair therapy><gene therapy><gene-based therapy><genetic therapy><genetically modified><genomic therapy><glial neural stem cell><glial progenitor><glial stem cell><immunogen><improved><in vivo><interest><knock-down><knockdown><membrane structure><neuroglial progenitor><neuroglial stem cells><neuronal><oligodendrocyte precursor><oligodendrocyte precursor cell><oligodendrocyte progenitor><oligodendrocyte stem cell><optical><overexpress><overexpression><platelet-derived growth factor receptor α><progenitor cell gene><progenitor gene><programs><promoter><promotor><receptor><research study><social role><stem cell genes><stem cells><success><synapse><tool><transgene><transgene delivery><transgene expression><tva gene product><vector>
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Camilla Ferreira Wenceslau

UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA, COLUMBIA, SC

Exploratory lead · 0/100
$186,250
FY 2025

Project Title

Reprogramming endothelial cells to prevent and treat Alzheimer disease (AD) and Hypertension

Grant Number:

5R21AG085331-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2024

End Date:

3/31/2026

Project Abstract

PROJECT SUMMARY WENCESLAU, CAMILLA F. Growing evidence supports a robust and likely causal association between cardiovascular disease (CVD), and its risk factors, with Alzheimer's disease (AD). However, standard paradigms such as “head to heart connection”, where heart failure leads to cerebral hypo...

Research Terms

<21+ years old><65 and older><65 or older><65 years of age and older><65 years of age or more><65 years of age or older><65+ years><65+ years old><> 65 years><AD dementia><AD model><Abeta synthesis><Acceleration><Adopted><Adult><Adult Human><Age><Aged 65 and Over><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease patient><Alzheimer's disease risk><Alzheimer's patient><Alzheimers Dementia><Amentia><American><Amyloid (Aβ) plaques><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Plaques><Amyloid Protein A4><Amyloid beta-Protein><Amyloid β><Amyloid β production><Amyloid β synthesis><Amyloid β-Peptide><Amyloid β-Protein><Animals><Anti-Hypertensive Agents><Anti-Hypertensive Drugs><Anti-Hypertensives><Area><Arteries><Aβ><Aβ production><Aβ synthesis><BP control><BP management><Basal Transcription Factor><Basal transcription factor genes><Blood Plasma><Blood Vessels><Blood flow><Brain><Brain Nervous System><Calcium><Cardiovascular Diseases><Cell Body><Cell Reprogramming><Cells><Cellular Stress><Cellular Stress Response><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Dementia><Deterioration><Development><Disease><Disorder><Disproportionate number of females><Disproportionate number of women><Disproportionately affects females><Disproportionately affects women><Disproportionately impacts females><Disproportionately impacts women><Disproportionately in females><Disproportionately in women><Disturbance in cognition><Dysfunction><ER stress><Encephalon><Endoplasmic Reticulum><Endothelial Cells><Endothelium><Ergastoplasm><Exhibits><Exploratory/Developmental Grant><Functional disorder><General Transcription Factor Gene><General Transcription Factors><Goals><Grant><Head><Heart><Heart failure><Human><Hypertension><Hypotensive Agent><Hypotensive Drugs><Impaired cognition><Incidence><Intervention Trial><Interventional trial><Laboratories><MT-bound tau><Mesenchymal><Mice><Mice Mammals><Modern Man><Murine><Mus><Nerve Cells><Nerve Unit><Neural Cell><Neuritic Plaques><Neurocyte><Neurofibrillary Tangles><Neurons><Neurotoxins><Organ><Perfusion><Persons><Phenotype><Physiopathology><Plasma><Plasma Serum><Play><Predisposition><Primary Senile Degenerative Dementia><Process><R21 Mechanism><R21 Program><Rejuvenation><Research><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Rodent><Rodentia><Rodents Mammals><Role><Senile Plaques><Single-Nucleus Sequencing><Solid><Susceptibility><Testing><Time><Transcription Factor Proto-Oncogene><Transcription factor genes><Vascular Diseases><Vascular Disorder><Vascular Endothelial Cell><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Woman><a beta peptide><aberrant folded protein><aberrant folded proteins><abeta><abeta production><abnormal folded protein><abnormal folded proteins><above age 65><adulthood><after age 65><age 65 and greater><age 65 and older><age 65 or older><age > 65><age of 65 years onward><aged 65 and greater><aged 65+><aged ≥65><ages><alzheimer model><alzheimer risk><amyloid beta><amyloid beta plaque><amyloid beta production><amyloid beta synthesis><amyloid-b plaque><amyloid-b protein><angiogenesis><anti-hypertension><aβ plaques><beta amyloid fibril><blood pressure control><blood pressure intervention><blood pressure management><blood vessel disorder><cardiac failure><cardiovascular disorder><cell stress><cellular reprogramming><cerebral hypoperfusion><cerebrovascular contributions to Alzheimer's disease><cerebrovascular dysfunction in Alzheimer's disease><cognitive dysfunction><cognitive loss><cored plaque><developmental><diffuse plaque><endoplasmic reticulum stress><endothelial dysfunction><exploratory developmental study><female bias><female predominance><female preponderance><high blood pressure><human old age (65+)><human tissue><hyperpiesia><hyperpiesis><hypertensive><hypertensive disease><hypertensive disorder><innovate><innovation><innovative><large data sets><large datasets><men><microtubule bound tau><microtubule-bound tau><misfolded protein><misfolded proteins><neural><neurofibrillary degeneration><neurofibrillary lesion><neurofibrillary pathology><neuronal><neurotoxicant><non-alzheimer's associated dementia><non-alzheimer's disease associated dementia><non-alzheimer's disease dementia><non-alzheimer's disease related dementia><non-alzheimer's related dementia><nonalzheimer dementia><nonalzheimer's disease associated dementia><older adult><older adulthood><over 65 years><overexpress><overexpression><pathophysiology><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><pluripotency><pluripotent state><predominance in females><predominance in women><pressure><prevent><preventing><primary degenerative dementia><programs><protein oligomer><proteotoxic protein><proteotoxin><repair><repaired><sNuc-Seq><senile dementia of the Alzheimer type><sex><single nucleus RNA-sequencing><single nucleus seq><single-nucleus RNA-seq><snRNA sequencing><snRNA-seq><social role><soluble amyloid precursor protein><tangle><tau><tau Proteins><tau factor><transcription factor><transdifferentiation><vascular><vascular burden on Alzheimer's disease><vascular contribution to Alzheimer's Disease><vascular contributions to AD><vascular contributions to Alzheimer's><vascular contributor to Alzheimer's disease><vascular dysfunction><vascular dysfunction in AD><vascular dysfunction in Alzheimer's disease><vasculopathy><women's predominance><women's preponderance><τ Proteins><≥65 years>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sara J Hussain

UNIVERSITY OF TEXAS AT AUSTIN, AUSTIN, TX

Exploratory lead · 0/100
$1
FY 2025

Project Title

Developing real-time personalized TMS to target residual corticospinal connections after stroke

Grant Number:

5R21NS133605-02

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

8/16/2025

Project Abstract

PROJECT SUMMARY Stroke commonly disrupts the corticospinal tract (CST) and impairs hand function. Transcranial magnetic stimulation (TMS) interventions that target and strengthen residual CST connections are promising candidates for improving poststroke hand function. To maximize their therapeutic e...

Research Terms

<21+ years old><Acquired brain injury><Adult><Adult Human><Affect><Algorithmic Analyses><Algorithmic Analysis><Algorithms><Analyses of Algorithms><Analysis of Algorithms><Apoplexy><Brain><Brain Injuries><Brain Nervous System><Brain Vascular Accident><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Communication><Corticospinal Tracts><Data><Dependence><Dorsal><EEG><Electroencephalogram><Electroencephalography><Encephalon><Exhibits><Exploratory/Developmental Grant><Foundations><Frequencies><Future><Goals><Hand><Hand functions><Human><Intervention><Lesion><Machine Learning><Methodology><Methods><Modern Man><Motor><Motor Cell><Motor Evoked Potentials><Motor Neurons><Movement><Muscle><Muscle Paresis><Muscle Tissue><Muscular Paresis><NIMH><NINDS><National Institute of Mental Health><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><Neural Transmission><Output><Paresis><Pathway interactions><Pattern><Performance><R21 Mechanism><R21 Program><Recovery><Reproducibility><Residual><Residual state><Rest><Stimulus><Stroke><Structure><Synaptic Transmission><Techniques><Therapeutic Effect><Time><Transcranial magnetic stimulation><Transmission><Using hands><Work><adulthood><after stroke><body movement><brain attack><brain damage><brain-injured><cerebral vascular accident><cerebrovascular accident><chronic stroke><design><designing><exploratory developmental study><hand dysfunction><hand function impairment><hand impairment><hands><impairment in hand function><improved><individual heterogeneity><individual variability><individual variation><individualized predictions><large scale data><large scale data sets><large scale datasets><machine based learning><machine learning based classifier><machine learning based framework><machine learning classifier><machine learning framework><motoneuron><motor deficit><muscular><novel><paretic><paretic muscle><pathway><personalized predictions><post stroke><poststroke><recruit><response><stroke intervention><stroke survivor><stroked><strokes><transmission process><virtual>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Search NIH grants by PI name

Looking for a specific principal investigator? The keyword search above looks up funded projects by topic. To search NIH grants by PI name (last name, first + last name, or partial name) and see every active and recent NIH award for that researcher, use the dedicated PI Funding Status tool.

How to Use PI Funding Data for Career Decisions

Finding the right principal investigator is one of the most important decisions in an academic career. Whether you are a postdoc looking for a mentor, a graduate student choosing a rotation lab, or a collaborator seeking a co-PI, NIH funding data provides objective signals about which investigators have active research programs and resources to support new team members.

A PI with a recently awarded R01 or equivalent grant is more likely to have budget for new personnel than one whose funding ended two years ago. The activity code tells you the type of grant: R01 and R35 awards typically support multiple lab members, while K-series awards are individual career development grants that may not fund additional positions. Understanding these distinctions helps you interpret search results accurately.

Look beyond the dollar amount. A $500,000 per year R01 at a high-cost institution may support fewer positions than a $300,000 award at a university with lower overhead rates. The project abstract and public health relevance statement reveal whether the PI's research direction aligns with your interests and expertise.

Understanding PI Grant Portfolios

A PI's grant portfolio reveals more than individual awards. Investigators with multiple active grants often run larger labs with more diverse projects, which can mean more opportunities for trainees. However, a PI with a single well-funded grant may offer more focused mentorship and a clearer path to publications.

Multi-PI grants (those with more than one principal investigator listed) indicate collaborative research and may involve trainees from multiple institutions. These can be excellent opportunities for interdisciplinary training but may also mean split attention from any single mentor.

Pay attention to the timing of awards. A PI who just received a new five-year R01 is in a different position than one whose grant ends next year. New awards often correspond to lab expansion and active recruiting, making them ideal targets for job seekers. The start and end dates shown in each result help you assess this timing.

Best Practices for Contacting Funded PIs

Once you identify a promising PI through this tool, the next step is outreach. NIH public records do not include email addresses, but you can usually find contact information through the PI's institutional profile page, lab website, or recent publications. Google Scholar, PubMed, and the PI's department website are reliable starting points.

When reaching out, reference the specific grant that caught your attention. Mentioning the project title and explaining how your skills relate to the funded work shows that you have done your homework. Keep your initial message concise: introduce yourself, explain your interest, attach your CV, and ask whether they anticipate openings.

Timing matters. Contacting a PI within the first year of a new award is ideal, as this is when they are most likely to be recruiting. If you find multiple promising PIs in the same field, prioritize those with the most recent award notices and activity codes that support trainee positions such as R01, U01, or P-series grants.

Frequently Asked Questions About PI Search

What does the opportunity score mean?

The opportunity score is a heuristic that combines award recency, funding amount, activity code type, and project characteristics to estimate how actionable a result might be for job seekers or collaborators. Higher scores suggest stronger signals, but always verify by reading the abstract and checking the PI's current lab page.

Why can't I find a PI I know has funding?

Name variations are the most common cause. Try searching with just the last name, or use different formats like "Smith, John" versus "John Smith." Some PIs also publish under different name variations or may have awards under a previous institutional affiliation.

Does this tool show all NIH-funded PIs?

The tool searches NIH RePORTER data for the keyword and year range you specify. It returns PIs whose funded projects match your search terms. PIs with grants in unrelated areas or whose projects use different terminology will not appear in keyword-filtered results.

What is the difference between "Likely hiring" and "Training-friendly" filters?

"Likely hiring" flags PIs with large new awards or activity codes typically associated with lab expansion. "Training-friendly" identifies awards that include training components or are at institutions known for postdoctoral programs. Both are heuristic filters to help prioritize your outreach.

How to use this well

Start broad, then narrow. Search a field first, then refine by timeframe once you understand who is currently active.

After you find a promising PI, cross-check them in Check PI Funding and review their institution, mechanism type, and project abstracts before reaching out.

What a match means

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Use the abstract, award year, mechanism, and organization context to decide whether the record is strategically relevant.

Data limits

NIH records can lag, institutional names can vary, and some investigators publish or file awards under multiple name formats.

For details on source coverage and refresh cadence, read Data & Methodology.

Related guides

Companion guides for turning a PI search result into useful outreach or a job lead.

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A tactical job-search guide for identifying recently funded labs, judging fit, and timing outreach to principal investigators.

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How to Contact a PI: Finding Emails and Crafting the Perfect Message

Emailing strategies, outreach examples, and a workflow for turning NIH funding signals into focused PI conversations.

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How to Read a New NIH Award Like a Hiring Signal

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Recently Funded Labs in Trending Areas

Principal investigators who received NIH awards in the last 90 days, organized by research area. Use this as a starting point for postdoc searches, collaborator outreach, or competitor scans. Counts and labs refresh daily.

Alzheimer's disease

Neurodegeneration, biomarkers, and disease-modifying therapies.

  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $101,153 · awarded Feb 25, 2026 · 3U01AG084514-01A1S1
  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $3,086,339 · awarded Feb 19, 2026 · 1U01AG084514-01A1
  • HARALD SONTHEIMER — UNIVERSITY OF VIRGINIA, VA
    Extracellular matrix and memory impairments in Alzheimer disease
    $709,066 · awarded Apr 7, 2026 · 5R01AG085359-03
  • Keith Josephs — MAYO CLINIC ROCHESTER, MN
    The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies
    $643,670 · awarded Apr 1, 2026 · 5R01DC014942-09
  • DMITRIY YABLONSKIY — WASHINGTON UNIVERSITY, MO
    Deep-Learning-Augmented Quantitative Gradient Recalled Echo (DLA-qGRE) MRI for in vivo Clinical Evaluation of Brain Microstructural Neurodegeneration in Alzheimer Disease
    $661,985 · awarded Mar 3, 2026 · 4R01AG082030-02
Search more PIs in Alzheimer's disease →

CRISPR & gene editing

Therapeutic gene editing, base editing, and prime editing.

  • Changchun Liu — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT
    Asymmetric CRISPR Approach for Nucleic Acid Quantification
    $643,849 · awarded Mar 30, 2026 · 2R01EB023607-06A1
  • William Pu — BOSTON CHILDREN'S HOSPITAL, MA
    A modular system for murine CRISPR genome and epigenome editing
    $267,000 · awarded Mar 27, 2026 · 5R21OD037909-02
  • Naama Aviram — SLOAN-KETTERING INST CAN RESEARCH, NY
    Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systems
    $249,000 · awarded Apr 2, 2026 · 5R00GM148720-04
  • Mats Ljungman — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Precision targeting of bladder cancer using CRISPR
    $582,849 · awarded Feb 17, 2026 · 5R01CA285730-03
  • Shannon Miller — SCRIPPS RESEARCH INSTITUTE, THE, CA
    Development of potent and safe CRISPR tools for in vivo gene editing using directed evolution
    $230,000 · awarded May 5, 2026 · 5R21EB036298-03
Search more PIs in CRISPR & gene editing →

Cancer immunotherapy

Checkpoint inhibitors, CAR-T, TIL therapy, and beyond.

  • TERRY SHEPPARD — KEYSTONE SYMPOSIA, CO
    Cancer Immunotherapy: Basic Mechanisms Informing Clinical Applications & Combinations
    $5,000 · awarded Mar 3, 2026 · 1R13CA310704-01
  • Veronika Fedirko — UNIVERSITY OF TX MD ANDERSON CAN CTR, TX
    Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma
    $927,329 · awarded Mar 3, 2026 · 5R01CA255322-05
  • Yuwen Zhu — UNIVERSITY OF COLORADO DENVER, CO
    The GPR171 pathway in cancer immunotherapy
    $355,706 · awarded Apr 2, 2026 · 5R01CA279398-04
  • ANDREW WIEMER — UNIVERSITY OF CONNECTICUT STORRS, CT
    Synthesis and evaluation of BTN3A1 ligands for cancer immunotherapy
    $374,171 · awarded May 1, 2026 · 5R01CA266138-05
  • Wei Hu — YALE UNIVERSITY, CT
    Novel Treg inactivating approach for cancer immunotherapy via targeted protein degradation
    $482,312 · awarded Apr 6, 2026 · 1R01CA295942-01A1
Search more PIs in Cancer immunotherapy →

GLP-1 & metabolic disease

Diabetes, obesity, and weight-loss therapeutic mechanisms.

  • ZHIPING PANG — RUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ
    Synaptic and circuit mechanisms of central GLP-1 signaling in energy balance
    $479,051 · awarded Apr 23, 2026 · 5R01DK131452-05
  • Madhusmita Misra — UNIVERSITY OF VIRGINIA, VA
    Bone metabolism in adolescents undergoing GLP-1 receptor agonist therapy
    $471,776 · awarded Apr 24, 2026 · 5R01HD118635-07
  • STEVEN SCHWENDEMAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Remote Loading of Melanocortin and GLP-1 Peptides in Polymers for Treatment of Obesity
    $231,000 · awarded Apr 17, 2026 · 1R56DK141545-01A1
  • Jessica Barson — DREXEL UNIVERSITY, PA
    Suppression of ethanol dependence-induced maladaptive appetitive and consummatory behavior by the GLP-1 system
    $564,306 · awarded May 5, 2026 · 1R01AA031732-01A1
  • MICHAEL CAMILLERI — MAYO CLINIC ROCHESTER, MN
    A Randomized, placebo-controlled trial of the effects of Long-Acting GLP-1 or Dual Incretin (GLP-1 and GIP) Modulation on Gastrointestinal Functions and Relationship to Weight Loss
    $322,800 · awarded Apr 9, 2026 · 5R01DK142606-02
Search more PIs in GLP-1 & metabolic disease →

Long COVID

Post-acute sequelae and chronic infection-driven illness.

  • Alexei Tumanov — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX
    Lymphotoxin-dependent control of long COVID
    $234,715 · awarded Feb 13, 2026 · 1R21AI185790-01A1
  • Amal Amer — OHIO STATE UNIVERSITY, OH
    Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
    $2,974,582 · awarded Apr 21, 2026 · 5P01AI175399-03
  • Alba Azola — JOHNS HOPKINS UNIVERSITY, MD
    Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 onset ME/CFS versus Pre-Pandemic ME/CFS Patients
    $633,378 · awarded Apr 17, 2026 · 1R01NS147100-01
  • DANIELLE REED — MONELL CHEMICAL SENSES CENTER, PA
    Inflammation and chemosensory loss
    $2,654,249 · awarded Feb 26, 2026 · 1P50DC022549-01A1
  • Jarred Younger — UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL
    Low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
    $556,686 · awarded Mar 6, 2026 · 1UG3NS141843-01A1
Search more PIs in Long COVID →