NIH Grant Search by PI — Funded Principal Investigator Finder

Search NIH grants by PI name or research area. Look up funded principal investigators, see their NIH RePORTER awards, institutions, and project details.

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Enter a research topic, disease, or technology to find principal investigators with NIH funding in that area. To look up a specific PI by name, use the PI Funding Status check.

Search Results

Found 182 principal investigators from 200 displayed projects for "R03" (2021–2026)

Note: 764 projects matched but only the first 200 were analyzed. Try narrowing your search with a more specific term or selecting "Project title only".

Opportunity Digest

Heuristic scoring to help trainees and job seekers prioritize which labs to inspect first.

0

High-opportunity leads

18

Likely hiring signals

18

Training-friendly awards

19

Average opportunity score

Prioritize records with strong opportunity signals, then validate fit using abstracts, institution pages, and lab websites.

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Elizabeth Goldberg

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$783,984
FY 2026

Project Title

GAPcareAD: A Brief Emergency Department Intervention to Address Post-Fall Care Needs of Persons Living with Dementia and Care Partners

Grant Number:

1R01AG091334-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2026

End Date:

2/28/2031

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Older adults with Alzheimer’s disease and related dementias (ADRD) fall up to eight times more often than older adults with normal cognition, incur higher fall treatment costs, and 40% experience adverse outcomes after emergency department (ED) visits (e.g., ED revisits, hospitalizat...

Research Terms

<AD and related dementia><AD related dementia><ADRD><Accident and Emergency department><Acute><Address><Adherence><Adverse Experience><Adverse event><Affect><Age><Alzheimer's Disease and its related dementias><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease and related forms of dementia><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Amentia><Analgesic Management><Anti-Cholinergics><Anticholinergic Agents><Anticholinergics><Area><Burden on their caregivers><Care Givers><Care giver support><Caregiver Burden><Caregiver support><Caregivers><Caring><Characteristics><Clinic><Clinical Trials><Cognition><Communication><Communities><Cost Savings><Data><Decline in mobility><Decrease in mobility><Decreased mobility><Dementia><Diminished mobility><Dose><Drugs><ED care><ED patient><ED visit><ER care><ER patient><ER visit><Elderly><Emergency Care><Emergency Department><Emergency Department care><Emergency Department patient><Emergency Room care><Emergency Room patient><Emergency care visit><Emergency department visit><Emergency health care><Emergency hospital visit><Emergency medical care><Emergency room><Emergency room visit><Enrollment><Equilibrium><Ethnic Origin><Ethnicity><Event><Exclusion><Fall prevention><Funding><Future><Gait><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Hip Fractures><Home Care><Hospital Admission><Hospitalization><Hour><Individual><Injury><Intervention><Interview><Length of Stay><Link><Measures><Medicare><Medicare claim><Medication><Medication Management><Mobility decline><Mobility impairment><Modification><Number of Days in Hospital><Out-patients><Outcome><Outpatients><Participant><Patients><Persons><Pharmaceutical Preparations><Pharmacies><Pharmacists><Pharmacologic Management><Pharmacy facility><Preventative intervention><Prevention program><Primary Care><Public Health><QOL><Quality of life><Race><Races><Randomized, Controlled Trials><Recommendation><Recurrence><Recurrent><Reduced mobility><Reduction in mobility><Reporting><Research><Research Design><Risk Factors><Severities><Site><Social isolation><Spottings><Study Type><Title 18><Transmission><Transportation><Treatment Cost><Visit><Wait Time><acute care><advanced age><adverse consequence><adverse outcome><ages><balance><balance function><burden in caregivers><burden of their caregivers><burden on caregivers><care as usual><care coordination><care giving><care partner><caregiving><caregiving partner><community factor><community-level factor><compare to control><comparison control><coordinating care><dementia care><deprivation><design><designing><drug/agent><efficacy testing><enroll><fall risk><falls><future implementation><geriatric><health insurance for disabled><health related quality of life><hospital days><hospital length of stay><hospital stay><improved><indexing><individual patient><injuries><intervention for prevention><medicare cost><medicare expenditures><medicare payments><medicare reimbursement><medicare spending><medication therapy management><memory care><mortality><older adult><older adulthood><participant engagement><patient engagement><patient home care><patient homecare><physical therapist><physiotherapist><preventing falls><prevention intervention><prevention service><preventional intervention strategy><preventive intervention><primary outcome><programs><racial><racial background><racial origin><randomized control trial><satisfaction><senior citizen><sex><social capital><study design><systematic review><transmission process><treatment as usual><treatment effect><uptake><usual care>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Tolu O. Oyesanya

DUKE UNIVERSITY, DURHAM, NC

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$669,762
FY 2026

Project Title

A Randomized Controlled Trial of BETTER, A Transitional Care Intervention, for Patients with Traumatic Brain Injury and Their Families

Grant Number:

5R01NR020818-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/19/2023

End Date:

2/28/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Patients with TBI (age 18 and older) with mild-to-severe traumatic brain injury (TBI) face high incidence and hospitalization rates, and poor cognitive, physical, behavioral, and emotional impairments <12 months post-discharge. These impairments affect patients’ abilities to independently manage the...

Research Terms

<18 year old><18 years of age><2 arm RCT><2 arm randomized control trial><2 arm randomized controlled trial><21+ years old><Access to Care><Acquired brain injury><Activities of Daily Living><Activities of everyday life><Acute><Address><Adult><Adult Human><Affect><Apoplexy><Area><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Brain Injuries><Brain Trauma><Brain Vascular Accident><Cardiac infarction><Caring><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Clinical><Clinical Skills><Cognitive><Communities><Complex><Conditioning Therapy><Coping Skills><Cost Analyses><Cost Analysis><Dependence><Discharge from Health Care Facility><Education><Education and Training><Educational aspects><Effectiveness><Emotional><Ensure><Event><Face><Family><Future><Goals><Health><Health Care><Health Services Accessibility><Health system><Home><Hour><Impairment><Incidence><Individual><Insurance><Intervention><Interview><Knowledge><Location><Manuals><Myocardial Infarct><Myocardial Infarction><NIH><Names><National Institutes of Health><Outcome><Participant><Patient Care><Patient Care Delivery><Patient Discharge><Patient Transfer><Patients><Patients with traumatic brain injury><Persons><Pilot Projects><Process><Protocol><Protocols documentation><Provider><Public Health><QOL><Quality of life><Randomized><Randomized, Controlled Trials><Recovery><Research><Research Methodology><Research Methods><Research Resources><Resources><SF-36><Self Management><Services><Site><Stroke><Structure><Symptoms><TBI Patients><TBI recovery><Training><Training and Education><Transitional Care Planning><Traumatic Brain Injury><Traumatic Brain Injury recovery><United States National Institutes of Health><acceptability and feasibility><access to health services><access to services><access to treatment><accessibility to health services><adulthood><age 18><age 18 years><arm><assess cost><availability of services><behavior intervention><behavioral intervention><brain attack><brain damage><brain-injured><budget impact><cardiac infarct><care access><care as usual><care coordination><care costs><care for patients><care giver strain><care of patients><caregiver strain><caring for patients><cerebral vascular accident><cerebrovascular accident><clinical encounter><clinical practice><coordinating care><coping strategy><coronary attack><coronary infarct><coronary infarction><cost><cost assessment><cost evaluation><daily living function><daily living functionality><design><designing><determine efficacy><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><eighteen year old><eighteen years of age><evaluate cost><evaluate efficacy><evidence base><examine cost><examine efficacy><faces><facial><family management><functional ability><functional capacity><health care service><health service access><health services availability><heart attack><heart infarct><heart infarction><homes><hospital care><hospital re-admission><hospital readmission><hospitalization rates><improved><improved outcome><multi-site trial><multisite trial><name><named><naming><pilot study><primary outcome><randomisation><randomization><randomized control trial><randomly assigned><re-admission><re-hospitalization><readmission><recovery after TBI><recovery after traumatic brain injury><recruit><rehospitalization><research and methods><secondary outcome><service availability><standard of care><stroked><strokes><theories><traumatic brain damage><traumatic brain injury patients><treatment access><treatment as usual><two arm RCT><two arm randomized control trial><two arm randomized controlled trial><usual care>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Kejia Cai

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$628,443
FY 2026

Project Title

Noninvasive High-Resolution Mapping of HCC Tumor Biology Predictive of Malignancy

Grant Number:

5R01CA283548-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/11/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT: Hepatocellular carcinoma (HCC) is an aggressive malignancy representing the 7th most common cancer globally and the 4th most common cause of cancer death worldwide. Although magnetic resonance imaging (MRI) represents a common HCC diagnostic and prognostic tool, MRI fails to provid...

Research Terms

<Ablation><Abscission><Address><Area><Artifacts><Biochemical><Biopsy><Blood Serum><Blood Vessels><CK MiMi><CRISPR><CRISPR/Cas system><Cancer Cause><Cancer Etiology><Cancer Model><CancerModel><Cancers><Cell Body><Cells><Cessation of life><Characteristics><Chemicals><Clinical><Clinical Management><Clustered Regularly Interspaced Short Palindromic Repeats><Collection><Creatine><Creatine Phosphate><Curative Surgery><Cytosol><Death><Development><Diagnosis><Diagnostic><Differential Display><Diffusion><Engineering><Evaluation><Excision><Extirpation><Family suidae><Funding><Gene Targeting><Generalized Growth><Genes><Genetic Heterogeneity><Goals><Grant><Growth><Hepatic Cancer><Hepatocarcinoma><Hepatocarcinoma model><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Heterogeneity><Human><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><In Vitro><Intermediary Metabolism><Intratumoral heterogeneity><Invaded><KRAS(G12D)><KRASG12D><Kinetics><Knock-out><Knockout><Knowledge><Liver><Liver Cells Carcinoma><Location><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malignant><Malignant - descriptor><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of liver><Maps><Measurement><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metabolic><Metabolic Processes><Metabolism><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Monitor><Morphologic artifacts><Motion><NMR Imaging><NMR Tomography><Natural regeneration><Nodule><Nuclear Magnetic Resonance Imaging><Oncopig><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Performance><Phosphocreatine><Phosphorylcreatine><Pigs><Population><Primary Malignant Neoplasm of Liver><Primary carcinoma of the liver cells><Primary liver cancer><Prognosis><Proliferating><Protocol><Protocols documentation><RF ablation><Radio Frequency Ablation><Radiofrequency Ablation><Radiofrequency Interstitial Ablation><Recurrence><Recurrent><Regeneration><Removal><Resolution><Respiration><Risk Assessment><Sensitivity and Specificity><Serum><Suidae><Surgical Removal><Survival Rate><Swine><System><Techniques><Testing><Therapeutic><Tissue Growth><Transgenic Organisms><Tumor Biology><Tumor Burden><Tumor Load><Zeugmatography><cancer cell metabolism><cancer metabolism><cancer progression><clinical practice><clinical relevance><clinically relevant><developmental><diagnostic biomarker><diagnostic marker><diagnostic tool><differential display technique><diffused><diffuses><diffusing><diffusions><effective therapy><effective treatment><empowerment><genetic profiling><hepatic body system><hepatic organ system><hepatocellular carcinoma cancer model><hepatocellular carcinoma model><heterogeneity in tumors><high definition><high-resolution><imaging><improved><in vivo><innovate><innovation><innovative><insight><intra-tumoral heterogeneity><intrahepatic><intratumor heterogeneity><knock-down><knockdown><liver cancer><liver cancer model><liver cancer patient><liver carcinoma><liver malignancy><mRNA Differential Displays><malignancy><malignant liver tumor><migration><mitochondrial creatine kinase><molecular profile><molecular signature><multidisciplinary><neoplasm progression><neoplasm/cancer><neoplastic progression><non-invasive imaging><noninvasive imaging><ontogeny><overexpress><overexpression><patient oriented outcomes><patient prognosis><pig model><piglet model><porcine><porcine model><prognostic tool><regenerate><research study><resection><resolutions><respiratory><respiratory mechanism><response to therapy><response to treatment><risk stratification><stratify risk><suid><swine model><therapeutic response><therapeutic stratification><therapy response><transgenic><treatment response><treatment responsiveness><treatment stratification><tumor><tumor cell metabolism><tumor growth><tumor heterogeneity><tumor metabolism><tumor progression><vascular>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ron C Gaba

UNIVERSITY OF ILLINOIS AT CHICAGO, Chicago, IL

Good lead · 66/100
Likely hiring
Above-average budget
Recent
Active award
$628,443
FY 2026

Project Title

Noninvasive High-Resolution Mapping of HCC Tumor Biology Predictive of Malignancy

Grant Number:

5R01CA283548-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/11/2024

End Date:

2/28/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT ABSTRACT: Hepatocellular carcinoma (HCC) is an aggressive malignancy representing the 7th most common cancer globally and the 4th most common cause of cancer death worldwide. Although magnetic resonance imaging (MRI) represents a common HCC diagnostic and prognostic tool, MRI fails to provid...

Research Terms

<Ablation><Abscission><Address><Area><Artifacts><Biochemical><Biopsy><Blood Serum><Blood Vessels><CK MiMi><CRISPR><CRISPR/Cas system><Cancer Cause><Cancer Etiology><Cancer Model><CancerModel><Cancers><Cell Body><Cells><Cessation of life><Characteristics><Chemicals><Clinical><Clinical Management><Clustered Regularly Interspaced Short Palindromic Repeats><Collection><Creatine><Creatine Phosphate><Curative Surgery><Cytosol><Death><Development><Diagnosis><Diagnostic><Differential Display><Diffusion><Engineering><Evaluation><Excision><Extirpation><Family suidae><Funding><Gene Targeting><Generalized Growth><Genes><Genetic Heterogeneity><Goals><Grant><Growth><Hepatic Cancer><Hepatocarcinoma><Hepatocarcinoma model><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Heterogeneity><Human><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><In Vitro><Intermediary Metabolism><Intratumoral heterogeneity><Invaded><KRAS(G12D)><KRASG12D><Kinetics><Knock-out><Knockout><Knowledge><Liver><Liver Cells Carcinoma><Location><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malignant><Malignant - descriptor><Malignant Neoplasms><Malignant Tumor><Malignant neoplasm of liver><Maps><Measurement><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metabolic><Metabolic Processes><Metabolism><Modern Man><Molecular><Molecular Fingerprinting><Molecular Profiling><Monitor><Morphologic artifacts><Motion><NMR Imaging><NMR Tomography><Natural regeneration><Nodule><Nuclear Magnetic Resonance Imaging><Oncopig><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Performance><Phosphocreatine><Phosphorylcreatine><Pigs><Population><Primary Malignant Neoplasm of Liver><Primary carcinoma of the liver cells><Primary liver cancer><Prognosis><Proliferating><Protocol><Protocols documentation><RF ablation><Radio Frequency Ablation><Radiofrequency Ablation><Radiofrequency Interstitial Ablation><Recurrence><Recurrent><Regeneration><Removal><Resolution><Respiration><Risk Assessment><Sensitivity and Specificity><Serum><Suidae><Surgical Removal><Survival Rate><Swine><System><Techniques><Testing><Therapeutic><Tissue Growth><Transgenic Organisms><Tumor Biology><Tumor Burden><Tumor Load><Zeugmatography><cancer cell metabolism><cancer metabolism><cancer progression><clinical practice><clinical relevance><clinically relevant><developmental><diagnostic biomarker><diagnostic marker><diagnostic tool><differential display technique><diffused><diffuses><diffusing><diffusions><effective therapy><effective treatment><empowerment><genetic profiling><hepatic body system><hepatic organ system><hepatocellular carcinoma cancer model><hepatocellular carcinoma model><heterogeneity in tumors><high definition><high-resolution><imaging><improved><in vivo><innovate><innovation><innovative><insight><intra-tumoral heterogeneity><intrahepatic><intratumor heterogeneity><knock-down><knockdown><liver cancer><liver cancer model><liver cancer patient><liver carcinoma><liver malignancy><mRNA Differential Displays><malignancy><malignant liver tumor><migration><mitochondrial creatine kinase><molecular profile><molecular signature><multidisciplinary><neoplasm progression><neoplasm/cancer><neoplastic progression><non-invasive imaging><noninvasive imaging><ontogeny><overexpress><overexpression><patient oriented outcomes><patient prognosis><pig model><piglet model><porcine><porcine model><prognostic tool><regenerate><research study><resection><resolutions><respiratory><respiratory mechanism><response to therapy><response to treatment><risk stratification><stratify risk><suid><swine model><therapeutic response><therapeutic stratification><therapy response><transgenic><treatment response><treatment responsiveness><treatment stratification><tumor><tumor cell metabolism><tumor growth><tumor heterogeneity><tumor metabolism><tumor progression><vascular>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Sukirth Murthy Ganesan

UNIVERSITY OF IOWA, IOWA CITY, IA

Good lead · 60/100
Likely hiring
Above-average budget
Active award
$699,184
FY 2026

Project Title

Determining the Impact of Metabolic Syndrome on the Oral Microbiome and Periodontal Health Using a Longitudinal Systems Biology Approach

Grant Number:

1R01DE034679-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/15/2026

End Date:

12/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Metabolic Syndrome (MetS) affects over one-third of U.S. adults and is closely linked with oral health issues, particularly periodontitis. The bidirectional relationship between MetS and periodontitis exacerbates both conditions, but the underlying mechanisms remain unclear. Our prel...

Research Terms

<21+ years old><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><BMI><BMI percentile><BMI z-score><Bacteroides gingivalis><Biochemical><Biological Markers><Blood Pressure><Body mass index><Buccal Cavity><Buccal Cavity Head and Neck><Cardiovascular Diseases><Cavitas Oris><Chronic><Chronic Periodontitis><Clinical><Clinical Research><Clinical Study><Data><Development><Disease><Disorder><Dissociation><Dose><Drug Therapy><Ecologic Systems><Ecological Systems><Ecosystem><Environment><Epidemic><Equation><Foundations><Funding><Future><Gas Chromatography><Gingival Crevicular Fluid><Gingival Exudate><Goals><Gum Disease><Health><High Prevalence><Immune system><Inflammation><Inflammation Mediators><Inflammatory><Insulin Resistance><Interdisciplinary Research><Interdisciplinary Study><Intervention><Investigation><Ketosis-Resistant Diabetes Mellitus><Knowledge><LC/MS><Life Style Modification><Link><Lipids><Longitudinal Studies><Longitudinal Surveys><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Maturity-Onset Diabetes Mellitus><Mediating><Mediation><Medical><Metabolic><Metabolic syndrome><Modeling><Molecular><Monitor><Mouth><Mouth microbiome><Multidisciplinary Collaboration><Multidisciplinary Research><NIDDM><Natural History><Nature><Negotiating><Negotiation><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Obesity><Operative Procedures><Operative Surgical Procedures><Oral><Oral cavity><Oral health><P gingivalis><P. gingivalis><Parodontosis><Pathogenicity><Pathway interactions><Patients><Periodontal Diseases><Periodontitis><Pharmacological Treatment><Pharmacotherapy><Physiologic><Physiological><Porphyromonas gingivalis><Prognostic Marker><Public Health><Quetelet index><Resolution><Risk><Sampling><Selenomonas><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Surgical><Surgical Interventions><Surgical Procedure><System><Systems Biology><T2 DM><T2D><T2DM><Techniques><Testing><Therapeutic><Time><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Variant><Variation><Virulent><Weight><adipocytokines><adipokines><adiposity><adult onset diabetes><adulthood><alter microbiome><bio-markers><biologic marker><biomarker><cardiovascular disorder><clinical effect><cohort><corpulence><cytokine><decision tree learning><dental health><design><designing><developmental><drug intervention><drug treatment><dysbacteriosis><dysbiosis><dysbiotic><healthy weight><high risk><host microbiota><host microflora><improved><inflammatory mediator><insight><insulin resistant><insulin tolerance><intervention effect><ketosis resistant diabetes><learning algorithm><life style intervention><lifestyle intervention><lifestyle modification><liquid chromatography mass spectrometry><long-term study><longitudinal outcome studies><longitudinal research study><maturity onset diabetes><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><microbial><microbial imbalance><microbiome><microbiome adaptation><microbiome alteration><microbiome perturbation><molecular biomarker><molecular marker><obese patients><oral microbiome><pathway><patients with obesity><periodontal disorder><periodontium disease><periodontium disorder><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><post intervention><prognostic><prognostic biomarker><prognostic indicator><programs><resident microbes><resident microflora><resolutions><response><small molecule><subgingival microbiome><surgery><type 2 DM><type II DM><type two diabetes><vapor phase chromatography><weights>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Jeffrey Andrew Sparks

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$694,961
FY 2025

Project Title

Rheumatoid Arthritis-Related Autoantibodies, Articular Inflammation, and RA-Associated Interstitial Lung Disease

Grant Number:

5R01AR077607-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/27/2021

End Date:

6/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

PROJECT SUMMARY Rheumatoid arthritis (RA) is a systemic autoimmune disease affecting nearly 1% of adults causing a painful, destructive inflammatory arthritis with serious long-term consequences including chronic pain, disability, accumulation of morbidities, and excess mortality. Patients with RA a...

Research Terms

<21+ years old><Acetaldehyde><Adult><Adult Human><Affect><Atrophic Arthritis><Autoantibodies><Autoimmune Status><Autoimmunity><Award><Blood Serum><CAT scan><CCP peptide><CT X Ray><CT Xray><CT imaging><CT scan><Causality><Chest><Clinical><Colorado><Complication><Computed Tomography><Data><Data Set><Derivation><Derivation procedure><Detection><Development><Diathesis><Disease><Disease susceptibility><Disorder><Ethanal><Etiology><Excess Mortality><Exposure to><Fibrosis><Foundations><Funding><General Hospitals><Genetic><Genotype><Glass><Goals><High Resolution Computed Tomography><Hospitals><Image><Inflammation><Inflammatory Arthritis><Inhalant dose form><Interstitial Lung Diseases><Investigation><Investigators><Isoenzymes><Isozymes><Joints><Life Style><Lifestyle><Link><Liquid substance><Lung><Lung Inflammation><Lung Respiratory System><Lung damage><MG1><MUC5B><MUC5B gene><Malonaldehyde><Malondialdehyde><Malonylaldehyde><Malonyldialdehyde><Massachusetts><Measures><Medicine><Michigan><Mission><Morbidity><Morbidity - disease rate><Mucosa><Mucosal Tissue><Mucous Membrane><NIAMS><NIH><National Institute of Arthritis, and Musculoskeletal, and Skin Diseases><National Institutes of Health><Nested Case-Control Study><Observation research><Observation study><Observational Study><Observational research><Outcome><Pain><Painful><Pathogenesis><Patient Recruitments><Patients><Performance><Phenotype><Pneumonitis><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Predisposition><Preventative strategy><Prevention strategy><Preventive strategy><Process><Production><Propanedial><Prospective cohort><Protein Modification><Protein-arginine deiminase><Proteins><Pulmonary Inflammation><Registries><Research><Research Personnel><Researchers><Rheumatoid Arthritis><Rheumatoid Factor><Risk><Risk Factors><Role><Scanning><Serum><Site><Smoker><Smoking><Smoking History><Sputum><Surface><Susceptibility><Symptoms><Testing><Thorace><Thoracic><Thorax><Tomodensitometry><United States National Institutes of Health><Universities><Variant><Variation><Woman><X-Ray CAT Scan><X-Ray Computed Tomography><X-Ray Computerized Tomography><Xray CAT scan><Xray Computed Tomography><Xray computerized tomography><adulthood><arthritis registry><autoimmune antibody><autoreactive antibody><biobank><biorepository><catscan><causation><chest CT><chest computed tomography><chronic autoimmune disease><chronic pain><clinical risk><cohort><computed axial tomography><computer based prediction><computer tomography><computerized axial tomography><computerized tomography><cyclic citrullinated peptide><developmental><disability><disease causation><disease phenotype><disease risk><disorder risk><fluid><high resolution CT><high risk><imaging><improved><inhalant><insight><liability to disease><liquid><lung injury><medical college><medical schools><mortality><neo-antigen><neo-epitopes><neoantigens><neoepitopes><non-contrast CT><noncontrast CT><noncontrast computed tomography><pack/year><participant enrollment><participant recruitment><patient enrollment><patient registry><patient stratification><peptidylarginine deiminase><predictive modeling><prevent><preventing><professor><promoter><promotor><prospective><protein-L-arginine iminohydrolase><pulmonary><pulmonary damage><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><rheumatic arthritis><school of medicine><screening><screenings><self reactive antibody><seropositive><social role><stratified patient><systemic autoimmune disease><systemic autoimmune disorder><systemic inflammation><systemic inflammatory response>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Petter Bjornstad

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$677,909
FY 2025

Project Title

Advancing ADPKD Treatment with GLP-1RA: A Study of Glucagon-Like Peptide-1 Receptor Agonists' Efficacy, Safety, and Mechanism

Grant Number:

5R01DK138915-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2024

End Date:

5/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that leads to kidney failure. The only approved treatment to decelerate kidney disease progression in patients with ADPKD is tolvaptan, but its usage is limited due to frequent side effects affecting ...

Research Terms

<21+ years old><ACRP30 protein><ADPKD><Acceleration><Acetates><Adherence><Adipose tissue><Adult><Adult Human><Adult Polycystic Kidney Disease><Adverse Experience><Adverse event><Affect><Agonist><Alternative Therapies><Alternative intervention><Attenuated><Autosomal Dominant Polycystic Kidney><Autosomal Dominant Polycystic Kidney Disease><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BMI><BMI percentile><BMI z-score><BSF-2><BSF2><Biological><Biological Markers><Blood><Blood Reticuloendothelial System><Body Weight><Body Weight decreased><Body mass index><C-reactive protein><Caloric Restriction><Cell Respiration><Cellular Respiration><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Clinical Trials><Cystic kidney><D-Glucose><Data><Deceleration><Dextrose><Diabetes Mellitus><Diet><Disease Management><Disease Progression><Disorder Management><Dominant Polycystic Kidney Disease><Dose><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Drug Therapy><Drugs><Endocrinology><Ensure><Euglycemic Clamping><Euglycemic-hyperinsulinemic Clamp><Event><Exhibits><FDA approved><Face><Fatty Tissue><Funding><GLP-1 receptor><GLP-I receptor><General Population><General Public><Generalized Growth><Glucose><Glucose Clamp><Growth><HPGF><Height><Hepatocyte-Stimulating Factor><Hereditary Disease><Humulin R><Hybridoma Growth Factor><Hyperinsulinemic Clamp><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><Inborn Genetic Diseases><Individual><Inflammation><Inherited disorder><Insulin><Insulin Resistance><Interleukin-6><Intervention><Isoprostanes><Kidney><Kidney Cyst><Kidney Diseases><Kidney Failure><Kidney Insufficiency><Kidney Urinary System><Label><Leptin><Link><MGI-2><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Metabolic><Metabolism and Endocrinology><Monitor><Myeloid Differentiation-Inducing Protein><NMR Imaging><NMR Tomography><Nephrology><Nephropathy><Novolin R><Nuclear Magnetic Resonance Imaging><Ob Gene Product><Ob Protein><Obese Gene Product><Obese Protein><Obesity><Outcome><Over weight><Overweight><Oxidative Stress><PET><PET Scan><PET imaging><PETSCAN><PETT><Participant><Patients><Perfusion><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phase><Phase 2 Clinical Trials><Phase II Clinical Trials><Pilot Projects><Placebo Control><Placebos><Plasmacytoma Growth Factor><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Prevalence><Property><Proteins, specific or class, C-reactive><Questionnaires><Quetelet index><Rad.-PET><Randomized><Regular Insulin><Renal Cyst><Renal Disease><Renal Failure><Renal Insufficiency><Renal function><Safety><Sampling><Sham Treatment><Tissue Growth><Urine><Visceral><Weight><Weight Loss><Weight Reduction><Weight maintenance regimen><Zeugmatography><abdominal adiposity><abdominal fat><adipocyte complement-related protein 30-kDa><adipocyte, C1q and collagen domain containing protein><adipocytokines><adipokines><adiponectin><adipose><adiposity><adulthood><aerobic metabolism><aerobic respiration><apM-1 protein><apM1 (adipose-specific) protein><attenuate><attenuates><bio-markers><biologic><biologic marker><biomarker><body weight loss><calorie restriction><chronic kidney disease><corpulence><cost><determine efficacy><diabetes><diets><drug intervention><drug treatment><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experience><faces><facial><fat metabolism><glucagon-like peptide-1 receptor><hereditary disorder><heritable disorder><improved><inborn error><inflammation marker><inflammatory marker><inherited diseases><inherited genetic disease><inherited genetic disorder><insight><insulin resistant><insulin sensitivity><insulin tolerance><interferon beta 2><kidney disorder><kidney function><kidney metabolism><kidney preservation><life style intervention><lifestyle intervention><lipid metabolism><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><obesity intervention><obesity therapy><obesity treatment><ontogeny><oxidative metabolism><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phase II protocol><pilot study><placebo controlled><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><premature><prematurity><primary outcome><protective effect><randomisation><randomization><randomly assigned><renal><renal disorder><response><safety assessment><secondary outcome><sham therapy><side effect><subcutaneous><subdermal><tolvaptan><urinary><weight control><weight management><weights><white adipose tissue><wt-loss><yellow adipose tissue>
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Kristen Lynn Nowak

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$677,909
FY 2025

Project Title

Advancing ADPKD Treatment with GLP-1RA: A Study of Glucagon-Like Peptide-1 Receptor Agonists' Efficacy, Safety, and Mechanism

Grant Number:

5R01DK138915-02

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2024

End Date:

5/31/2029

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that leads to kidney failure. The only approved treatment to decelerate kidney disease progression in patients with ADPKD is tolvaptan, but its usage is limited due to frequent side effects affecting ...

Research Terms

<21+ years old><ACRP30 protein><ADPKD><Acceleration><Acetates><Adherence><Adipose tissue><Adult><Adult Human><Adult Polycystic Kidney Disease><Adverse Experience><Adverse event><Affect><Agonist><Alternative Therapies><Alternative intervention><Attenuated><Autosomal Dominant Polycystic Kidney><Autosomal Dominant Polycystic Kidney Disease><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BMI><BMI percentile><BMI z-score><BSF-2><BSF2><Biological><Biological Markers><Blood><Blood Reticuloendothelial System><Body Weight><Body Weight decreased><Body mass index><C-reactive protein><Caloric Restriction><Cell Respiration><Cellular Respiration><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Clinical Trials><Cystic kidney><D-Glucose><Data><Deceleration><Dextrose><Diabetes Mellitus><Diet><Disease Management><Disease Progression><Disorder Management><Dominant Polycystic Kidney Disease><Dose><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Drug Therapy><Drugs><Endocrinology><Ensure><Euglycemic Clamping><Euglycemic-hyperinsulinemic Clamp><Event><Exhibits><FDA approved><Face><Fatty Tissue><Funding><GLP-1 receptor><GLP-I receptor><General Population><General Public><Generalized Growth><Glucose><Glucose Clamp><Growth><HPGF><Height><Hepatocyte-Stimulating Factor><Hereditary Disease><Humulin R><Hybridoma Growth Factor><Hyperinsulinemic Clamp><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><Inborn Genetic Diseases><Individual><Inflammation><Inherited disorder><Insulin><Insulin Resistance><Interleukin-6><Intervention><Isoprostanes><Kidney><Kidney Cyst><Kidney Diseases><Kidney Failure><Kidney Insufficiency><Kidney Urinary System><Label><Leptin><Link><MGI-2><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medication><Metabolic><Metabolism and Endocrinology><Monitor><Myeloid Differentiation-Inducing Protein><NMR Imaging><NMR Tomography><Nephrology><Nephropathy><Novolin R><Nuclear Magnetic Resonance Imaging><Ob Gene Product><Ob Protein><Obese Gene Product><Obese Protein><Obesity><Outcome><Over weight><Overweight><Oxidative Stress><PET><PET Scan><PET imaging><PETSCAN><PETT><Participant><Patients><Perfusion><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Phase><Phase 2 Clinical Trials><Phase II Clinical Trials><Pilot Projects><Placebo Control><Placebos><Plasmacytoma Growth Factor><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Prevalence><Property><Proteins, specific or class, C-reactive><Questionnaires><Quetelet index><Rad.-PET><Randomized><Regular Insulin><Renal Cyst><Renal Disease><Renal Failure><Renal Insufficiency><Renal function><Safety><Sampling><Sham Treatment><Tissue Growth><Urine><Visceral><Weight><Weight Loss><Weight Reduction><Weight maintenance regimen><Zeugmatography><abdominal adiposity><abdominal fat><adipocyte complement-related protein 30-kDa><adipocyte, C1q and collagen domain containing protein><adipocytokines><adipokines><adiponectin><adipose><adiposity><adulthood><aerobic metabolism><aerobic respiration><apM-1 protein><apM1 (adipose-specific) protein><attenuate><attenuates><bio-markers><biologic><biologic marker><biomarker><body weight loss><calorie restriction><chronic kidney disease><corpulence><cost><determine efficacy><diabetes><diets><drug intervention><drug treatment><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experience><faces><facial><fat metabolism><glucagon-like peptide-1 receptor><hereditary disorder><heritable disorder><improved><inborn error><inflammation marker><inflammatory marker><inherited diseases><inherited genetic disease><inherited genetic disorder><insight><insulin resistant><insulin sensitivity><insulin tolerance><interferon beta 2><kidney disorder><kidney function><kidney metabolism><kidney preservation><life style intervention><lifestyle intervention><lipid metabolism><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><obesity intervention><obesity therapy><obesity treatment><ontogeny><oxidative metabolism><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><phase II protocol><pilot study><placebo controlled><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><premature><prematurity><primary outcome><protective effect><randomisation><randomization><randomly assigned><renal><renal disorder><response><safety assessment><secondary outcome><sham therapy><side effect><subcutaneous><subdermal><tolvaptan><urinary><weight control><weight management><weights><white adipose tissue><wt-loss><yellow adipose tissue>
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KATHRYN E DEMOS

MIRIAM HOSPITAL, PROVIDENCE, RI

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$570,515
FY 2025

Project Title

Adapting Episodic Future Thinking for Behavioral Weight Loss: Comparing Strategies and Characterizing Treatment Response

Grant Number:

5R01DK128412-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/23/2021

End Date:

8/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary/Abstract Obesity is one of the most important public health issues today, contributing to many of the leading causes of morbidity and mortality in the United States. Despite strong desires to achieve long-term weight loss goals, individuals with obesity tend to overvalue immediate r...

Research Terms

<Active Follow-up><Adherence><After Care><After-Treatment><Aftercare><Age><Attention><Behavior><Behavioral><Body Image><Body Weight Changes><Body Weight decreased><Characteristics><Cognitive><Coupled><Data><Decision Making><Diet><Exercise><Exhibits><Feedback><Female><Food><Food Preferences><Functional MRI><Functional Magnetic Resonance Imaging><Future><Gender><Goals><Health><Health behavior><Individual><Individual Differences><Intake><Literature><Measurement><Measures><Mediating><Mental Depression><Modeling><Morbidity><Morbidity - disease rate><Obesity><Outcome><Over weight><Overweight><Participant><Pattern><Physical activity><Predictive Factor><Prevention><Process><Public Health><Randomized><Randomized, Controlled Trials><Research><Rewards><Self-control as a personality trait><Testing><Thinking><Training><Training Programs><Treatment Protocols><Treatment Regimen><Treatment Schedule><United States><Weight><Weight Change><Weight Loss><Weight Reduction><Weight maintenance regimen><Work><active followup><adiposity><adverse consequence><adverse outcome><ages><behavioral economics><body perception><body weight loss><corpulence><craving><customized therapy><customized treatment><demographics><depression><diet choice><diet preference><dietary choice><dietary preferences><diets><discount><discounting><experience><fMRI><follow up><follow-up><followed up><followup><food choice><health related behavior><imaging study><improved><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><insight><internet based delivery><internet delivered><internet delivery><intervention effect><male><mortality><motivated behavior><neural control><neural regulation><neuromodulation><neuromodulatory><neuroregulation><new approaches><novel><novel approaches><novel strategies><novel strategy><obesity intervention><obesity therapy><obesity treatment><patient specific therapies><patient specific treatment><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pilot trial><pleasure><post treatment><prevent><preventing><primary outcome><programs><randomisation><randomization><randomized control trial><randomly assigned><response><response to therapy><response to treatment><satisfaction><self control><standard care><standard treatment><success><tailored medical treatment><tailored therapy><tailored treatment><theories><therapeutic response><therapy response><thoughts><treatment response><treatment responsiveness><treatment strategy><unique treatment><weight control><weight loss intervention><weight loss program><weight loss programming><weight loss therapy><weight loss treatment><weight management><weights><wt-loss><♀><♂>
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Ladda Thiamwong

UNIVERSITY OF CENTRAL FLORIDA, ORLANDO, FL

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$537,700
FY 2025

Project Title

Optimizing a technology-based body and mind intervention to prevent falls and reduce health disparities in low-income populations

Grant Number:

5R01MD018025-04

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/26/2022

End Date:

6/30/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Falls and fear of falling (FOF) are the leading cause of injury, disability, and hospitalization in low-income older adults (LOA). Lack of motivation, limited resources, low education, and inconvenience remain barriers to participate in fall prevention programs. More than half of older adults have m...

Research Terms

<Accelerometer><Active Follow-up><Address><Adoption><Aging><Balance training><Categories><Cognitive><Collaborations><Communities><Control Groups><Data><Decrease health disparities><Education><Educational aspects><Effectiveness><Enrollment><Equilibrium><Exercise><Fall prevention><Feedback><Goals><Health disparity mitigation><Health disparity reduction><Home><Hospital Admission><Hospitalization><Independent Living><Injury><Intention><Intervention><Interview><Low Income Population><Low income><Low income group><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Lower health disparities><Mind><Mitigate health disparities><Motivation><Outcome Measure><Participant><Perception><Performance><Personal awareness><Personalized medical approach><Physical activity><Physiologic><Physiological><Pilot Projects><Prevention program><Psyche structure><Public Health><Publishing><Randomized, Controlled Trials><Reduce health disparities><Research><Research Resources><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Risk Reduction><Sampling><Self Perception><Self image><Self view><Single-Blind Study><Single-blind><Structure><System><Technology><Time><accelerometry><acceptability and feasibility><active followup><activity monitor><activity tracker><arm><balance><balance function><barrier to care><barrier to health care><barrier to treatment><community living><compare to control><comparison control><cost><disability><enroll><exercise program><experience><fall risk><falls><fear of falling><fitness program><follow up><follow-up><followed up><followup><health organization><healthy aging><healthy human aging><home test><home-based test><homes><implementation cost><implementation investment><improved><individualized approach><injuries><innovative technologies><intervention effect><intervention program><low income individual><low income people><measurable outcome><mental><mind/body><moderate-to-vigorous physical activity><muscle strengthening><novel><obstacle to care><obstacle to health care><older adult><older adulthood><outcome measurement><peer><personalized approach><pilot study><portability><precision approach><prevent><preventing><preventing falls><programs><racial diversity><racially diverse><randomized control trial><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk-reducing><screening><screenings><sedentary><self awareness><self knowledge><strength training><tailored approach><technology intervention><technology platform><technology system><technology-based interventions><technology-enabled interventions><technology-focused interventions><train balance>
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Kristen Lynn Nowak

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Good lead · 54/100
Likely hiring
Above-average budget
Active award
$515,538
FY 2025

Project Title

Daily Caloric Restriction in Overweight and Obese Adults with ADPKD

Grant Number:

5R01DK129259-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2021

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Project Summary Autosomal dominant polycystic kidney disease (ADPKD) is a common inherited disorder that leads to end- stage kidney disease. To date, tolvaptan is the only approved intervention to slow kidney disease progression in patients with ADPKD. However, tolvaptan is constrained by high cost ...

Research Terms

<(hydroxymethylglutaryl-CoA reductase (NADPH)) kinase><21+ years old><5'-AMP-activated protein kinase><ACRP30 protein><ADPKD><AFBP><AMP-activated kinase><AMP-activated protein kinase><AMPK enzyme><Abdomen><Adherence><Adipocytes><Adipose Cell><Adipose tissue><Adult><Adult Human><Adult Polycystic Kidney Disease><Affect><Alpha-Pregnancy-Associated Endometrial Globulin><Amniotic Fluid Binding Protein><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Autosomal Dominant Polycystic Kidney><Autosomal Dominant Polycystic Kidney Disease><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BMI><BMI percentile><BMI z-score><BSF-2><BSF2><Behavioral><Binding Protein-25><Binding Protein-26><Binding Protein-28><Biological><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Serum><Body Tissues><Body Weight decreased><Body fat><Body mass index><C-reactive protein><Caloric Restriction><Cancers><Cell Communication and Signaling><Cell Signaling><Chronic><Clinical><Clinical Research><Clinical Study><Clinical Trials><Control Groups><Cyst><Cystic kidney><Data><Defect><Development><Disease><Disease Management><Disease Progression><Disorder><Disorder Management><Dominant Polycystic Kidney Disease><ESKD><ESRD><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Endocrine Glands><Endocrine Organs><Epithelium><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Fat Cells><Fats><Fatty Tissue><Fatty acid glycerol esters><Feasibility Studies><Funding><General Population><General Public><Generalized Growth><Genetic Diseases><Growth><Growth Hormone Independent-Binding Protein><HMG CoA reductase (NADPH) kinase><HMG CoA reductase kinase><HMG coenzyme A reductase (NADPH) kinase><HPGF><Height><Hepatocyte-Stimulating Factor><Hereditary Disease><Hybridoma Growth Factor><IBP-1><IBP1><IFN-beta 2><IFNB2><IGF-1><IGF-BP25><IGF-Binding Protein 1><IGF-I><IGF-I-SmC><IGFBP-1><IGFBP1><IGFBP1 gene><IL-6><IL6 Protein><Inborn Genetic Diseases><Individual><Inflammatory><Inherited disorder><Insulin-Like Growth Factor 1><Insulin-Like Growth Factor I><Insulin-Like Growth-Factor Binding Protein 1><Insulin-Like Somatomedin Peptide I><Interleukin-6><Intermediary Metabolism><Intervention><Intracellular Communication and Signaling><Kidney><Kidney Cyst><Kidney Diseases><Kidney Urinary System><Leptin><Life><Link><Lipocytes><Liquid substance><MGI-2><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Malignant Neoplasms><Malignant Tumor><Mature Lipocyte><Mature fat cell><Measures><Mechanistic Target of Rapamycin><Mediating><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Metabolic><Metabolic Processes><Metabolism><Myeloid Differentiation-Inducing Protein><NMR Imaging><NMR Tomography><Nephropathy><Nuclear Magnetic Resonance Imaging><Ob Gene Product><Ob Protein><Obese Gene Product><Obese Protein><Obesity><Over weight><Overweight><PBMC><PP12><Pathway interactions><Patients><Peripheral Blood Mononuclear Cell><Pilot Projects><Plasmacytoma Growth Factor><Proliferating><Proteins, specific or class, C-reactive><Quetelet index><RAFT1><Randomized Controlled Clinical Trials><Recommendation><Renal Cyst><Renal Disease><Renal function><Reporting><Ribosomal Protein S6 Kinase><Rodent Model><S6 Kinase><S6-H4 Kinase><STAT3><STAT3 gene><Safety><Sample Size><Sampling><Serum><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Somatomedin C><Tissue Growth><Tissues><Translating><Visceral><Visceral fat><Weight Loss><Weight Reduction><Zeugmatography><abdominal adiposity><abdominal fat><acceptability and feasibility><adipocyte complement-related protein 30-kDa><adipocyte, C1q and collagen domain containing protein><adipocytokines><adipokines><adiponectin><adipose><adiposity><adult adiposity><adult obesity><adulthood><adults with obesity><apM-1 protein><apM1 (adipose-specific) protein><bio-markers><biologic><biologic marker><biological signal transduction><biomarker><body weight loss><calorie restriction><clinical practice><clinical translation><clinically translatable><comparable efficacy><comparative efficacy><compare efficacy><corpulence><cost><cytokine><decline in function><decline in functional status><determine efficacy><developmental><dietary><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><fluid><food restriction><functional decline><functional status decline><genetic condition><genetic disorder><hereditary disorder><heritable disorder><hydroxymethylglutaryl-CoA-reductase kinase><improved outcome><inborn error><inflammation marker><inflammatory marker><inherited diseases><inherited genetic disease><inherited genetic disorder><insight><interferon beta 2><kidney disorder><kidney function><life style intervention><lifestyle intervention><liquid><mTOR><malignancy><mammalian target of rapamycin><neoplasm/cancer><novel><ontogeny><pathway><pilot study><primary outcome><randomized control clinical trial><renal><renal disorder><secondary outcome><side effect><subcutaneous><subdermal><systemic inflammation><systemic inflammatory response><tolvaptan><tumorigenic><weight loss intervention><weight loss therapy><weight loss treatment><white adipose tissue><wt-loss><yellow adipose tissue>
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Elizabeth Genevieve Mietlicki-Baase

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Good lead · 52/100
Likely hiring
Solid budget
Active award
$350,484
FY 2026

Project Title

Effects of mesolimbic amylin signaling on macronutrient intake

Grant Number:

5R01DK128030-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2021

End Date:

11/30/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary/Abstract Obesity is highly prevalent in the United States, yet available treatment options remain limited. The peptide hormone amylin, which reduces food intake and body weight, is thought to be a promising potential target for novel obesity treatments. As obesity is driven in part ...

Research Terms

<1,2-Benzisothiazol-3(2H)-one, 1,1-dioxide><Acute><Address><Adeno-Associated Viruses><Affect><Anorectic Drug><Anorectic agent><Anorectics><Anorexiant><Anorexic Drugs><Anorexient Agent><Anorexient Drug><Anorexigenic Drugs><Appetite Depressants><Appetite Suppressants><Appetite-Depressing Drugs><Appetite-Suppressant Drugs><Aquadiol><Area><Automobile Driving><Award><Behavioral><Behavioral Mechanisms><Body Weight><Body Weight decreased><Brain><Brain Nervous System><CNS Nervous System><Carbohydrates><Cell Body><Cell Communication and Signaling><Cell Nucleus><Cell Signaling><Cells><Central Nervous System><Chronic><Common Rat Strains><Communication><Consumption><Cost of Illness><Cyclicity><DA Neuron><Dependoparvovirus><Dependovirus><Development><Diet><Differences between sexes><Differs between sexes><Dimenformon><Diogyn><Diogynets><Disease Costs><Dopamine><Dopamine neuron><Drug Therapy><Eating><Encephalon><Endocrine Gland Secretion><Estrace><Estradiol><Estradiol-17 beta><Estradiol-17beta><Estraldine><Estrous Cycle><Fats><Fatty acid glycerol esters><Feedback><Female><Food><Food Intake><Hormones><Hydroxytyramine><Hyperphagia><IAPP receptor><Insulinoma amyloid peptide><Intake><Intracellular Communication and Signaling><Light><Liquid substance><Literature><Macronutrient Intake><Macronutrients><Macronutrients Nutrition><Mechanisms of Behavior and Behavior Change><Mediating><Motivation><Nerve Cells><Nerve Impulse Transmission><Nerve Transmission><Nerve Unit><Neural Cell><Neuraxis><Neurocyte><Neuronal Transmission><Neurons><Nucleus><Nucleus Accumbens><Obesity><Oophorectomy><Ovariectomy><Overeating><Ovocyclin><Ovocylin><Pancreas><Pancreatic><Pathway interactions><Peptide Hormone Gene><Peptides><Periodicity><Persons><Pharmacological Treatment><Pharmacotherapy><Phase><Photoradiation><Physiologic><Physiological><Physiology><Population><Progynon><Publishing><Rat><Rats Mammals><Rattus><Receptor Activation><Receptor Signaling><Research><Rewards><Rhythmicity><Role><Saccharin><Saccharose><Scanning><Sex Differences><Sexual differences><Sickness Cost><Signal Transduction><Signal Transduction Systems><Signaling><Site><Stimulus><Sucrose><System><Testing><Therapeutic Estradiol><United States><Ventral Tegmental Area><Weight Gain><Weight Increase><Weight Loss><Weight Reduction><Work><adeno associated virus group><adiposity><amlintide><amylin><amylin receptor><anorexic agent><axon signaling><axon-glial signaling><axonal signaling><behavior mechanism><biological signal transduction><body weight gain><body weight increase><body weight loss><corpulence><design><designing><developmental><diabetes associated peptide><dietary><diets><dopaminergic neuron><driving><drug intervention><drug treatment><eat less><energy balance><feeding><female gonadectomy><fluid><glia signaling><glial signaling><insight><insulinoma amyloid polypeptide><interest><islet amyloid polypeptide><islet amyloid polypeptide receptor><knock-down><knockdown><liquid><macronutrient consumption><male><motivated behavior><nerve signaling><neural><neural mechanism><neural signaling><neuromechanism><neuronal><neuronal signaling><neurotransmission><novel><obesity intervention><obesity therapy><obesity treatment><pancreatic amylin><pathway><peptide hormone><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><polyphagia><receptor expression><reduced eating><reduced food intake><response><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><social role><treatment strategy><ventral tegmentum><wt gain><wt-loss><♀><♂>
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Michael Peter Combs

VANDERBILT UNIVERSITY MEDICAL CENTER, NASHVILLE, TN

Good lead · 48/100
Training-friendly
Recent
Active award
Career award
$176,886
FY 2026

Project Title

Advancing our Understanding of the Development, Phenotypes, and Progression of Chronic Rejection after Lung Transplantation

Grant Number:

7K23HL171904-03

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract Michael Combs, MD, MS is a Pulmonary and Critical Care physician at the University of Michigan. This K23 proposal outlines the mentored research and training required for Dr. Combs to achieve his long-term goal of becoming an independent physician-scientist and a leader in u...

Research Terms

<Advisory Committees><Allografting><Azadose><Azithromycin><Azitrocin><Azythromycin><Bacteria><Biologic Factor><Biological><Biological Factors><Bronchioalveolar Lavage><Bronchiolitis Obliterans><Bronchoalveolar Lavage><Bronchoalveolar Lavage Fluid><Bronchopulmonary Lavage><Bronchoscopy><Caring><Cause of Death><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular biology><Cessation of life><Chronic><Clinical><Clinical Data><Clinical Research><Clinical Study><Clinical Trials><Clinical stratification><Comb animal structure><Combs><Communities><Complex><Computational Biology><Critical Care><Data><Death><Development><Development Plans><Diagnosis><Dimensions><Disease><Disorder><Doctor of Philosophy><Dysfunction><Exudative Bronchiolitis><Failure><Fibrotic lesions in lung><Functional disorder><Goals><Grafting Procedure><Immune response><Immune signaling><Immunology><Intracellular Communication and Signaling><Investigators><Lung><Lung Grafting><Lung Lavage><Lung Respiratory System><Lung Transplantation><Lung scar><Lung tissue scar><Machine Learning><Measures><Mentors><Mentorship><Mesenchymal><Michigan><Modeling><Morbidity><Newly Diagnosed><Organ Transplantation><Organ Transplants><Outcome><Pathogenesis><Patients><Ph.D.><PhD><Phenotype><Physicians><Physiologic><Physiological><Physiopathology><Position><Positioning Attribute><Precision care><Probabilistic Models><Probability Models><Prognosis><Proliferative Bronchiolitis><Publishing><Pulmonary Graft><Pulmonary Scar><Pulmonary Tissue fibrosis><Pulmonary Transplant><Pulmonary Transplantation><R-Series Research Projects><R01 Mechanism><R01 Program><Radiography><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Risk><Risk Factors><Roentgenography><Role><Scarring at the lung><Scarring in the lung><Scientist><Signal Transduction><Signal Transduction Systems><Signaling><Solid><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Statistical Models><Syndrome><Task Forces><Testing><Time><Training><Transplant Recipients><Transplantation><Ultreon><Universities><Variant><Variation><Work><Zithromax><Zitromax><advisory team><biologic><biological signal transduction><bronchiolar alveolar lavage><bronchopulmonary lavage therapy><career development><cell biology><clinical heterogeneity><clinical phenotype><clinical risk><cohort><computer based prediction><computer biology><customized therapy><customized treatment><design><designing><developmental><effective therapy><effective treatment><experience><fibrotic lung><host response><immune system response><immunoresponse><improved><improved outcome><individualized care><individualized medicine><individualized patient care><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><insight><lung allograft><lung function><lung microbial community><lung microbiome><lung microbiota><lung transplant><machine based learning><machine learning based model><machine learning model><microbiome><mortality><novel><organ allograft><organ graft><organ xenograft><pathophysiology><patient centered><patient oriented><patient specific therapies><patient specific treatment><personalized care><personalized patient care><post-transplant><post-transplantation><posttransplant><posttransplantation><predictive modeling><prognostic significance><prognostication><prospective><pulmonary><pulmonary function><pulmonary microbial community><pulmonary microbiome><pulmonary microbiota><radiological imaging><response to therapy><response to treatment><retransplantation><risk prediction algorithm><risk prediction model><risk prediction system><risk prediction tool><social role><statistical analysis><statistical linear mixed models><statistical linear models><tailored medical treatment><tailored therapy><tailored treatment><therapeutic response><therapy response><translational study><transplant><transplant patient><treatment response><treatment responsiveness><unique treatment>
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STEPHANIE T LANZA

PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA

Good lead · 46/100
Training-friendly
Above-average budget
Active award
$629,102
FY 2025

Project Title

Prevention and Methodology Training

Grant Number:

5T32DA017629-20

Activity Code:

T32

Mechanism:

Training, Institutional

Agency:

NIH

Start Date:

7/1/2005

End Date:

6/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Since 2005 the Prevention and Methodology Training Program (PAMT) T32 has met a critical need in the training of drug abuse prevention scientists by nurturing scientists focused on integrating prevention science and highly innovative methodology. The objective of PAMT, which is unique to NIDA’s port...

Research Terms

<Methodology><Prevention><Training>
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JENNIFER L MAGGS

PENNSYLVANIA STATE UNIVERSITY, THE, UNIVERSITY PARK, PA

Good lead · 46/100
Training-friendly
Above-average budget
Active award
$629,102
FY 2025

Project Title

Prevention and Methodology Training

Grant Number:

5T32DA017629-20

Activity Code:

T32

Mechanism:

Training, Institutional

Agency:

NIH

Start Date:

7/1/2005

End Date:

6/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.
  • • Award size is strong enough to merit immediate review.

Project Abstract

Since 2005 the Prevention and Methodology Training Program (PAMT) T32 has met a critical need in the training of drug abuse prevention scientists by nurturing scientists focused on integrating prevention science and highly innovative methodology. The objective of PAMT, which is unique to NIDA’s port...

Research Terms

<Methodology><Prevention><Training>
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Shelley Han Liu

ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI, NEW YORK, NY

Good lead · 46/100
Likely hiring
Solid budget
Active award
$390,337
FY 2025

Project Title

The PFAS exposure burden calculator: A novel tool for cross-study harmonization, biomonitoring and report-back

Grant Number:

1R01ES035804-01A1

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/25/2025

End Date:

5/31/2030

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

PROJECT SUMMARY Almost every person in the US has detectable levels of per- and polyfluoroalkyl substances (PFAS) in their blood. PFAS are a large class of >4,000 chemicals, known as toxic “forever chemicals”, that contribute to worse cardio-metabolic health, decreased immune functioning, and cancer...

Research Terms

<0-11 years old><Back><Behavior><Biological Markers><Biological Monitoring><Biometrics><Biometry><Biostatistics><Birth><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Calendar><Calibration><Cancers><Cellular Immune Function><Chemicals><Child><Child Youth><Childhood><Children (0-21)><Clinical><Cohort Studies><Computer software><Concurrent Studies><Data><Development><Diet><Dimensions><Dorsum><Education><Educational aspects><Engineering><Environmental Epidemiology><Environmental Exposure><Environmental Health><Environmental Health Science><Epidemiology><Exposure to><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Habits><Health><Heterogeneity><Home><Human><Human Figure><Human body><Hydrogen Oxide><Individual><Industry><Investigators><Laboratories><Life><Life Style><Lifestyle><Link><Literature><Maintenance><Malignant Neoplasms><Malignant Tumor><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Medicine><Meta-Analysis><Methodology><Methods><Modeling><Modern Man><Monitor><NHANES><NICHD><NIEHS><National Academy of Sciences><National Health and Nutrition Examination Survey><National Institute of Child Health and Human Development><National Institute of Environmental Health Sciences><Outcome><PFAS><Participant><Parturition><Pattern><Perinatal><Peripartum><Persons><Phase><Poly-fluoroalkyl substances><Production><Psychometrics><Publishing><Reporting><Research><Research Personnel><Researchers><Resistance><Resolution><Risk Assessment><Science><Sister><Software><Source><Staining method><Stains><Standardization><Statistical Methods><Sum><Temporal trend><Testing><Time><Time trend><Trends over time><United States National Academy of Sciences><Water><Work><bio-markers><biologic marker><biomarker><biomonitoring><cancer risk><cardiometabolic><cardiometabolism><clinical practice><consumer product><contaminated drinking water><developmental><diets><drinking water contamination><epidemiologic><epidemiological><geographic site><health data><high dimensionality><homes><immune function><kids><life span><lifespan><malignancy><manufacture><method development><multidisciplinary><neoplasm/cancer><novel><pediatric><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><polyfluorinated alkyl substances><polyfluoroalkyl substances><resistant><resolutions><response><simulation><statistic methods><substance use><substance using><theories><tool><youngster>
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Ken Catchpole

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 46/100
Likely hiring
Solid budget
Active award
$388,864
FY 2025

Project Title

System Optimization for Advances in Sterile Processing

Grant Number:

5R01HS027912-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

AHRQ

Start Date:

9/1/2021

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Sterile processing departments (SPDs) clean and pack reusable surgical instruments. They directly affect productivity, efficiency, safety, and infection control within acute interventional care. About 15% of surgical instrument trays have missing, broken or dirty instruments, that can lead to surgic...

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Michael F. Rayo

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Good lead · 46/100
Likely hiring
Solid budget
Active award
$388,864
FY 2025

Project Title

System Optimization for Advances in Sterile Processing

Grant Number:

5R01HS027912-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

AHRQ

Start Date:

9/1/2021

End Date:

8/31/2026

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Sterile processing departments (SPDs) clean and pack reusable surgical instruments. They directly affect productivity, efficiency, safety, and infection control within acute interventional care. About 15% of surgical instrument trays have missing, broken or dirty instruments, that can lead to surgic...

View Full Project Details on NIH Reporter
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Lisa K McLellan

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 46/100
Likely hiring
Solid budget
Active award
$374,511
FY 2025

Project Title

Mechanisms of Integrative and Conjugative Elements in Oral Bacteria

Grant Number:

7R01DE033403-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/3/2025

End Date:

5/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Streptococcus mutans resides in the oral cavity where it is known to initiate the development of dental caries (tooth decay). For this pathogen to thrive in the dynamic and variable environment of the mouth it must be adaptable both to short- and long-term ecological pressures. The h...

Research Terms

<0-11 years old><21+ years old><Address><Adult><Adult Human><Agriculture><Antibiotic Resistance><Bacteria><Bacterial Genome><Buccal Cavity><Buccal Cavity Head and Neck><CRISPR><CRISPR/Cas system><Caries><Cavitas Oris><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Morphology><Child><Child Youth><Children (0-21)><Clustered Regularly Interspaced Short Palindromic Repeats><Complex><DNA><DNA Damage><DNA Injury><Dental Decay><Dental Plaque><Dental caries><Deoxyribonucleic Acid><Diet><Disease><Disorder><Elements><Environment><Esteroproteases><Evolution><Gene Transfer><Generalized Growth><Genes><Genome><Goals><Growth><Heterogeneity><Horizontal Gene Transfer><Human><Intermediary Metabolism><Intracellular Communication and Signaling><Knowledge><Lateral Gene Transfer><Mediating><Metabolic Processes><Metabolism><Microbial Biofilms><Microscopy><Modeling><Modern Man><Molecular><Mouth><Mouth microbiome><Odontogenesis><Oral cavity><Outcome><Pathogenesis><Pathogenicity><Pathogenicity Factors><Pathway interactions><Peptidases><Peptide Hydrolases><Phenotype><Physiology><Population><Process><Production><Protease Gene><Proteases><Proteinases><Proteolytic Enzymes><Regulation><Resistance to antibiotics><Resistant to antibiotics><S mutans><S. mutans><Signal Transduction><Signal Transduction Systems><Signaling><Silencer Elements><Silencing Elements><Streptococcus mutans><System><Tissue Growth><Tooth Diseases><Tooth Disorder><Transcriptional Silencer Elements><Transmission><Virulence><Virulence Factors><Visualization><Work><adulthood><antibiotic drug resistance><antibiotic resistant><bacteria pathogen><bacterial pathogen><biofilm><biofilm community><biological adaptation to stress><biological signal transduction><carbohydrate metabolism><cell morphology><dental development><dental disease><dental disorder><derepression><design><designing><diets><insight><kids><mixed species biofilm><multi-microorganism biofilm><multispecies biofilm><novel><ontogeny><oral bacteria><oral flora><oral microbiome><pathogen><pathogenic bacteria><pathogenicity gene><pathway><polymicrobial biofilm><pressure><prevent><preventing><reactioncrisis><stress response><stress tolerance><stressreaction><tooth decay><trait><transmission process><virulence gene><virulent gene><youngster>
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Robert Colquhoun Shields

UNIVERSITY OF FLORIDA, GAINESVILLE, FL

Good lead · 46/100
Likely hiring
Solid budget
Active award
$374,511
FY 2025

Project Title

Mechanisms of Integrative and Conjugative Elements in Oral Bacteria

Grant Number:

7R01DE033403-03

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/3/2025

End Date:

5/31/2028

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

Project Summary Streptococcus mutans resides in the oral cavity where it is known to initiate the development of dental caries (tooth decay). For this pathogen to thrive in the dynamic and variable environment of the mouth it must be adaptable both to short- and long-term ecological pressures. The h...

Research Terms

<0-11 years old><21+ years old><Address><Adult><Adult Human><Agriculture><Antibiotic Resistance><Bacteria><Bacterial Genome><Buccal Cavity><Buccal Cavity Head and Neck><CRISPR><CRISPR/Cas system><Caries><Cavitas Oris><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Cellular Morphology><Child><Child Youth><Children (0-21)><Clustered Regularly Interspaced Short Palindromic Repeats><Complex><DNA><DNA Damage><DNA Injury><Dental Decay><Dental Plaque><Dental caries><Deoxyribonucleic Acid><Diet><Disease><Disorder><Elements><Environment><Esteroproteases><Evolution><Gene Transfer><Generalized Growth><Genes><Genome><Goals><Growth><Heterogeneity><Horizontal Gene Transfer><Human><Intermediary Metabolism><Intracellular Communication and Signaling><Knowledge><Lateral Gene Transfer><Mediating><Metabolic Processes><Metabolism><Microbial Biofilms><Microscopy><Modeling><Modern Man><Molecular><Mouth><Mouth microbiome><Odontogenesis><Oral cavity><Outcome><Pathogenesis><Pathogenicity><Pathogenicity Factors><Pathway interactions><Peptidases><Peptide Hydrolases><Phenotype><Physiology><Population><Process><Production><Protease Gene><Proteases><Proteinases><Proteolytic Enzymes><Regulation><Resistance to antibiotics><Resistant to antibiotics><S mutans><S. mutans><Signal Transduction><Signal Transduction Systems><Signaling><Silencer Elements><Silencing Elements><Streptococcus mutans><System><Tissue Growth><Tooth Diseases><Tooth Disorder><Transcriptional Silencer Elements><Transmission><Virulence><Virulence Factors><Visualization><Work><adulthood><antibiotic drug resistance><antibiotic resistant><bacteria pathogen><bacterial pathogen><biofilm><biofilm community><biological adaptation to stress><biological signal transduction><carbohydrate metabolism><cell morphology><dental development><dental disease><dental disorder><derepression><design><designing><diets><insight><kids><mixed species biofilm><multi-microorganism biofilm><multispecies biofilm><novel><ontogeny><oral bacteria><oral flora><oral microbiome><pathogen><pathogenic bacteria><pathogenicity gene><pathway><polymicrobial biofilm><pressure><prevent><preventing><reactioncrisis><stress response><stress tolerance><stressreaction><tooth decay><trait><transmission process><virulence gene><virulent gene><youngster>
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Megan L. Killian

UNIVERSITY OF MICHIGAN AT ANN ARBOR, ANN ARBOR, MI

Good lead · 46/100
Likely hiring
Solid budget
Active award
$363,591
FY 2025

Project Title

FGF signaling during growth and mechanical adaptation of tendon-bone interfaces

Grant Number:

5R01AR079367-05

Activity Code:

R01

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2021

End Date:

5/31/2027

Why this may be worth a closer look

  • • Mechanism often supports lab expansion or staff hiring.

Project Abstract

ABSTRACT The tendon-bone interface is a structurally graded fibrocartilage interface that is critical for transducing mechanical loads from muscle to the skeleton. Reduced muscle loading can lead to impaired interface growth and skeletal deformities. Recently, we have shown that the size of tendon-b...

Research Terms

<ACTA1><ACTA1 gene><Alleles><Allelomorphs><Anatomic Abnormality><Anatomical Abnormality><Behavior><Biomechanics><Body Tissues><Bone Growth><CEK2><Cell Body><Cell Communication and Signaling><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell Signaling><Cell-Extracellular Matrix><Cells><Chemicals><Chondrocytes><Clinical><DNA Synthesis Factor><DNA mutation><Deformity><Denervation><Development><Disease><Disorder><ECM><Embryo><Embryonic><Endothelial Cell Growth Factor><Epiphyseal Plate><Epiphysial cartilage><Extracellular Matrix><Extremities><FGF><FGF Receptors><FGF-9 protein><FGF-R><FGFBR><FGFR><FGFR-3><FGFR1><FGFR1 gene><FGFR3><FGFR3 gene><FLG Gene><FLT2 Gene><FMS-Like Gene><FMS-Like Tyrosine Kinase 2 Gene><Fibroblast Growth Factor><Fibroblast Growth Factor Gene Family><Fibroblast Growth Factor Receptor 1 Gene><Fibroblast Growth Factor Receptor Family><Fibroblast Growth Factor Receptors><Fibroblast Growth Regulatory Factor><Fibrocartilages><GLI Family Gene><GLI Family Protein><GLI Protein><GLI gene><GLI1><GLI1 Gene><GLI1 Protein><Generalized Growth><Genetic><Genetic Change><Genetic defect><Genetic mutation><Genotype><Glia-Activating Factor><Glioma Associated Oncogene Homolog 1 Protein><Glioma Associated Oncogene Homolog Protein><Glioma-Associated Oncogene Homolog><Glioma-associated oncogene><Goals><Growth><Growth Plate><HSFGFR3EX><Hypertrophy><Impairment><Intracellular Communication and Signaling><JTK4><Joints><Knock-out><Knockout><Knowledge><Ligands><Light><Limb structure><Limbs><Lineage Tracing><LoxP-flanked allele><Mechanics><Mediating><Mice><Mice Mammals><Modification><Murine><Mus><Muscle><Muscle Cell Contraction><Muscle Contraction><Muscle Tissue><Muscular Contraction><Mutation><NIH><National Institutes of Health><Non-Trunk><Osteoblasts><Pathologic Fracture><Pathological fracture><Phenocopy><Phenotype><Photoradiation><Physiologic pulse><Population><Progenitor Cells><Property><Pulse><Receptor Protein><Reporter><Role><Secondary to><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Skeletal Muscle><Skeleton><Source><Specificity><Spontaneous Fractures><Structure><Techniques><Tendon structure><Tendons><Testing><Tissue Growth><Tissues><Tyrosine Kinase JTK4><United States National Institutes of Health><Visualization><Voluntary Muscle><Work><actin, alpha 1><alpha skeletal muscle actin><biological signal transduction><biomechanical><bone><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell sorting><cellular lineage mapping><cellular lineage tracking><compare to control><comparison control><developmental><fibroblast growth factor 9><fibroblast growth factor receptor 3><fibrocartilaginous><floxed><floxed allele><gain of function><genome mutation><glial activating factor><glioma associated oncogene 1><glioma associated oncogene family zinc finger 1><hFGFR3><healing><in vivo><induced Cre><inducible Cre><innervation><innovate><innovation><innovative><loss of function><mechanic><mechanical><mechanical load><mouse model><murine model><muscular><mutant><neonatal mice><neonate><nerve supply><novel><ontogeny><optogenetics><postnatal><progenitor><receptor><response><skActin><skeletal><skeletal actin gene><skeletons><social role><stem cells><tendon development><tendon growth><tendon maturation><therapeutic target><tomography><tool>
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Michelle C Starr

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Exploratory lead · 42/100
Training-friendly
Active award
Career award
$182,416
FY 2026

Project Title

Improving the prediction of bronchopulmonary dysplasia by identifying kidney-based risk factors

Grant Number:

5K23HL168362-03

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

12/1/2023

End Date:

11/30/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Approximately 50,000 infants are born less than 28 weeks’ gestation in the United States each year, and the development of severe bronchopulmonary dysplasia (BPD) in these infants is common. However, difficulties with early identification of at-risk infants and incomplete knowledge of modifiable ris...

Research Terms

<Accuracy of Diagnosis><Acute Kidney Failure><Acute Kidney Insufficiency><Acute Renal Failure><Acute Renal Insufficiency><Ang-2><Ang2><Angiopoietin-2><Biological Markers><Biometrics><Biometry><Biostatistics><Blood Plasma><Bronchopulmonary Dysplasia><Caring><Chronic><Clinical><Clinical Data><Clinical Markers><Clinical Trials><Clinical Trials Design><Data><Death Rate><Detection><Development><Development Plans><Diagnosis><ECSF><Early Diagnosis><Early identification><Economic Burden><Education><Educational aspects><Epoetin><Erythropoietin><FIGF protein><Faculty><Fluid overload><Foundations><Funding><Future><Gestation><Goals><Grant><Health><Health Informatics><Health Services Evaluation><Health Services Research><Hospital Admission><Hospitalization><Impairment><Incidence><Infant><Intervention><Investigators><K23 Award><K23 Mechanism><K23 Program><Kidney><Kidney Diseases><Kidney Urinary System><Knowledge><Length of Stay><Link><Liquid substance><Lung><Lung Diseases><Lung Respiratory System><Machine Learning><Mechanical ventilation><Medical Care Research><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentors><Mentorship><Methods><Modeling><Monitor><Morbidity><NHLBI><National Heart, Lung, and Blood Institute><Neonatal><Nephropathy><Number of Days in Hospital><Organ><Outcome><Pattern><Plasma><Plasma Serum><Pregnancy><Premature Infant><Prevention><Public Health Informatics><Publishing><Pulmonary Diseases><Pulmonary Disorder><R-Series Research Projects><R01 Mechanism><R01 Program><Renal Disease><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Severities><Survivors><Testing><Treatment Protocols><Treatment Regimen><Treatment Schedule><United States><Update><VEGF><VEGF-D><VEGFs><Vascular Endothelial Growth Factor D><Vascular Endothelial Growth Factors><Work><acute kidney injury><angiogenesis><bench bed side><bench bedside><bench to bed side><bench to bedside><bench to clinic><bench to clinical practice><bio-markers><biologic marker><biomarker><c-fos-induced growth factor><candidate biomarker><candidate marker><career><career development><chronic lung disease in infants><chronic lung disease in neonatal infants><chronic lung disease in neonates><chronic lung disease in newborns><chronic lung disease in prematurity><chronic lung disease in preterm infants><chronic lung disease of infancy><chronic lung disease of prematurity><clinical biomarkers><clinical predictive model><clinically useful biomarkers><co-morbid><co-morbidity><cohort><comorbidity><computer based prediction><consumer informatics><death risk><developmental><diagnostic accuracy><disease of the lung><disorder of the lung><early detection><erythrocyte colony stimulating factor><extreme prematurity><extremely premature infant><extremely preterm><extremely preterm infant><fluid><hematopoietin><high risk><high risk infant><hospital days><hospital length of stay><hospital stay><hypervolemia><improved><infant chronic lung disease><infants born premature><infants born prematurely><infants with chronic lung disease><kidney development><kidney disorder><liquid><lung development><lung disorder><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><malleable risk><mechanical respiratory assist><mechanically ventilated><modifiable risk><mortality rate><mortality risk><multidisciplinary><neonatal chronic lung disease><neonatal period><nephrogenesis><neuroprotection><neuroprotective><new approaches><newborn chronic lung disease><novel><novel approaches><novel strategies><novel strategy><post-prematurity respiratory disease><predictive biological marker><predictive biomarkers><predictive marker><predictive modeling><predictive molecular biomarker><premature baby><premature infant human><preterm baby><preterm infant><preterm infant human><preterm infants with chronic lung disease><prevent><preventing><programs><pulmonary><renal><renal disorder><repair><repaired><respiratory><services research><translation strategy><translational approach><translational strategy><urinary><very premature><very preterm><vulnerable infant>
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DOUGLAS G BURRIN

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Exploratory lead · 38/100
Training-friendly
Solid budget
Active award
$423,504
FY 2025

Project Title

Research Training in Pediatrics Gastroenterolgy

Grant Number:

5T32DK007664-35

Activity Code:

T32

Mechanism:

Training, Institutional

Agency:

NIH

Start Date:

9/30/1991

End Date:

6/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

This is the renewal application for Years 31-35 of a training program designed to produce investigators at the cutting edge of research in pediatric gastroenterology. Trainees will be at the postdoctoral level and a mixture of MDs and PhDs supported for up to 3 years for a total request of 5 stipend...

Research Terms

<Pediatrics><Research Training>
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AARON M MILSTONE

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 38/100
Training-friendly
Solid budget
Active award
$397,203
FY 2025

Project Title

Research Training in Pediatric Infectious Diseases

Grant Number:

5T32AI052071-23

Activity Code:

T32

Mechanism:

Training, Institutional

Agency:

NIH

Start Date:

7/1/2002

End Date:

7/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

ABSTRACT The goal of the proposed training program is to continue to provide tailored, strong research skills and knowledge in the discipline of Pediatric Infectious Diseases for physician-scientists pursuing a career in academic Pediatrics. Our proposed training program is multidisciplinary, combin...

Research Terms

<Childhood><Communicable Diseases><Infectious Diseases><Infectious Disorder><Research Training><pediatric>
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JOEL N HIRSCHHORN

BOSTON CHILDREN'S HOSPITAL, BOSTON, MA

Exploratory lead · 38/100
Training-friendly
Solid budget
Active award
$396,875
FY 2025

Project Title

RESEARCH IN DEVELOPMENTAL ENDOCRINOLOGY AND METABOLISM

Grant Number:

5T32DK007699-44

Activity Code:

T32

Mechanism:

Training, Institutional

Agency:

NIH

Start Date:

7/1/1992

End Date:

6/30/2027

Why this may be worth a closer look

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Project Abstract

This training grant in developmental endocrinology and metabolism at Boston Children's Hospital (BCH) intends to provide funding for 4 postdoctoral fellows per year to engage in research training leading to independent careers in academic pediatric endocrinology. The program is designed to address t...

Research Terms

<Developmental Endocrinology><Endocrinology><Metabolism and Endocrinology><Research>
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Thomas Kofi Mensah Cudjoe

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$198,714
FY 2025

Project Title

Identifying and Addressing Social Isolation among Older Adults Living in Subsidized Housing

Grant Number:

5K23AG075191-04

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2022

End Date:

7/31/2027

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Project Abstract

PROJECT SUMMARY Social isolation is the objective lack of (or limited) social contact with others. Approximately 1 in 4 older adults are socially isolated. Social isolation is a major public health issue and a risk factor for morbidity and mortality comparable to smoking, hypertension, and a sedenta...

Research Terms

<Address><Aging><American><Baltimore><Basic Research><Basic Science><Behavioral Model><Caring><Characteristics><Chronic><Cities><Communities><Complex><Control Groups><Data><Development and Research><Economic Income><Economical Income><Epidemiology><Exposure to><Foundations><Functional impairment><Funding><Future><General Population><General Public><Gerontology><Grant><Groups at risk><Health><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Home><Hospital Admission><Hospitalization><Housing><Hypertension><Impaired health><Income><Individual><Institutionalization><Intervention><Investigation><Investigators><K23 Award><K23 Mechanism><K23 Program><Knowledge><Low income><Mediator><Medical><Medicare><Mental Health><Mental Hygiene><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Methodology><Methods><Modality><Modification><Morbidity><Morbidity - disease rate><NIH><National Institutes of Health><Needs Assessment><Nursing Homes><Operative Procedures><Operative Surgical Procedures><Outcome><Participant><Patient Self-Report><People at risk><Persons at risk><Population><Populations at Risk><Prevalence><Process><Protocol><Protocols documentation><Psychological Health><Public Health><R & D><R&D><Reporting><Research><Research Personnel><Research Resources><Research Support><Researchers><Resources><Risk><Risk Factors><Savings><Scientist><Sedentary behavior><Sedentary life-style><Self-Report><Site><Smoking><Social isolation><Structure><Surgical><Surgical Interventions><Surgical Procedure><Survey Instrument><Surveys><Testing><Title 18><United States National Institutes of Health><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Work><Writing><acceptability and feasibility><attentional control><career development><cohort><community advisory board><community advisory committee><community advisory panel><community engagement><community intervention><community level intervention><community-based intervention><cost><demographics><develop therapy><engagement with communities><epidemiologic><epidemiological><experience><gerontologic><health insurance for disabled><high blood pressure><homes><human centered design><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><implementation science><improved><incomes><innovate><innovation><innovative><insight><interest><intervention delivery><intervention development><intervention refinement><mortality><new approaches><novel approaches><novel strategies><novel strategy><nursing home><older adult><older adulthood><open label><open label study><peer><physical conditioning><physical health><post intervention><research and development><sedentary lifestyle><social><social contact><social determinants><sociodeterminant><structural determinants><structural factors><success><surgery><therapy development><treatment development>
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Amy Egbert

UNIVERSITY OF CONNECTICUT STORRS, STORRS-MANSFIELD, CT

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$195,072
FY 2025

Project Title

Examining Loss of Control Eating in Black Adolescents with Overweight/Obesity: The Role of Social Contexts and Social Stress

Grant Number:

5K23DK132500-04

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/15/2022

End Date:

8/31/2027

Why this may be worth a closer look

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Project Abstract

Rates of obesity for Black adolescents are among the highest of any racial or ethnic group in the United States, and loss of control over eating (LOC; being unable to control what or how much one is eating) confers greater risk for the development and maintenance of excess weight. LOC occurs in 25-4...

Research Terms

<12-20 years old><Address><Adolescence><Adolescent><Adolescent Youth><Adolescent obesity><Affective><Application Context><Area><Award><Behavior><Black><Black race><Calories><Characteristics><Clinical><Communities><Consultations><Consumption><Cultural Backgrounds><Data><Development><Distress><Eating><Eating Behavior><Eating Disorders><Ecological momentary assessment><Environment><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Exposure to><Family><Feedback><Feeling><Focus Groups><Food><Food Intake><Goals><Health><Health Food><Historical Demography><Intervention><Investigators><Language><Link><Low income><Maintenance><Measurement><Measures><Mentorship><Methods><Modeling><Motivation><Nature><Neighborhoods><Nutritious food><Obesity><Outcome><Over weight><Overweight><Participant><Persons><Population><Prevention program><Process><Protocol><Protocols documentation><Psychometrics><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Racial Group><Reporting><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Risk><Risk Factors><Role><Social Environment><Social Interaction><Socio-economic status><Socioeconomic Status><Stress><Time><Training><United States><Vulnerable Populations><Weight><Weight Gain><Weight Increase><Work><Youth><Youth 10-21><adiposity><adolescence (12-20)><body weight gain><body weight increase><career><community advisory board><community advisory committee><community advisory panel><community involvement><community partnership><consultation><contextual factors><coping><corpulence><critical period><design><designing><developmental><ethnic subgroup><ethnicity group><excessive weight gain><experience><exposure to violence><extreme weight gain><feelings><healthy food><innovate><innovation><innovative><juvenile><juvenile human><loss of control eating><loss of control over eating><obese adolescents><obesigenic><obesity among adolescents><obesity during adolescence><obesity in adolescence><obesity in adolescents><obesity intervention><obesity prevention><obesity therapy><obesity treatment><obesogenic><peer><prevent obesity><programs><racial><racial background><racial origin><racial population><racial subgroup><recruit><response><serious weight gain><severe weight gain><skills><social><social climate><social context><social role><social situation><social stress><social stresses><social stressor><socially stressed><socio-economic position><socioeconomic position><socioenvironment><socioenvironmental><sound><stressor><treatment program><violence exposure><vulnerable group><vulnerable individual><vulnerable people><weights><wt gain><youth adiposity><youth age>
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Carrie Down Johnston

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$194,445
FY 2025

Project Title

Aging with HIV: Novel Biomarkers of Inflammation and Morbidity

Grant Number:

5K23AG072960-05

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/15/2021

End Date:

4/30/2027

Why this may be worth a closer look

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Project Abstract

PROJECT SUMMARY/ABSTRACT The candidate’s career goal is to become an independent physician-scientist studying HIV and aging, and the increased burden of medical co-morbidities and geriatric syndromes in older adults with HIV (OAH). The candidate has laid the foundation for achieving this goal by gai...

Research Terms

<AIDS Virus><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Advisory Committees><Age><Aging><Anti-Retroviral Agents><Back><Biological Markers><Biostatistical Methods><Blood><Blood Plasma><Blood Plasma Cell><Blood Reticuloendothelial System><Body Weight decreased><Caring><Caryophyllus><Cell Body><Cell Death><Cells><Cessation of life><Chronic><Clinical><Co-culture><Cocultivation><Coculture><Coculture Techniques><Cognition><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><DNA><DNA Content><DNA Index><DNA Ploidy><Data><Death><Dedications><Deoxyribonucleic Acid><Disturbance in cognition><Dorsum><Drugs><Dysfunction><Elderly><Epidemic><Eugenia><Evaluation><Fostering><Foundations><Functional disorder><Gene Activation><Geriatrics><Geroscience><Goals><HIV><HIV Seronegativities><HIV Seronegativity><HIV negative><HTLV-III Seronegativities><HTLV-III Seronegativity><Human Immunodeficiency Viruses><IADL><IFN><Immune><Immune Cell Activation><Immunes><Immunologic Stimulation><Immunological Stimulation><Immunology><Immunostimulation><Impaired cognition><In Vitro><Inflammation><Inflammatory><Innate Immunity><Institution><Interferons><Intervention><Investigation><Investigators><LAV-HTLV-III><Link><Longitudinal Studies><Lymphadenopathy-Associated Virus><Master of Science><Master's Degree><Measurement><Measures><Mediating><Mediator><Medical><Medication><Mentors><Mentorship><Mitochondrial DNA><Molecular><Morbidity><Morbidity - disease rate><Native Immunity><Natural Immunity><Necrosis><Necrotic><Nested Case-Control Study><Neurocognitive><Neuropsychologies><Neuropsychology><Non-Specific Immunity><Nonspecific Immunity><Participant><Pattern><Performance><Pharmaceutical Preparations><Phenotype><Physical Function><Physical Performance><Physicians><Physiopathology><Plasma><Plasma Cells><Plasma Serum><Plasmacytes><Ploidies><Process><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Seq><RNA sequencing><RNAseq><Research><Research Design><Research Grants><Research Methodology><Research Methods><Research Personnel><Research Project Grants><Research Projects><Researchers><Reticuloendothelial System, Serum, Plasma><Risk><Role><Scientist><Stress><Study Type><Syndrome><Syzygium><Task Forces><Testing><Time><Training><Training Programs><Translational Research><Translational Science><Urine><Viral><Viremia><Virus-HIV><Visit><Weight Loss><Weight Reduction><advanced age><advisory team><ages><aging associated><aging related><anti-retroviral><bio-markers><biobank><biologic marker><biomarker><biorepository><body weight loss><career><career development><chromosome complement><clinical care><clinical investigation><co-morbid><co-morbidity><cognitive assessment><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><cognitive testing><cohort><comorbidity><drug/agent><experience><experiment><experimental research><experimental study><experiments><falls><forging><frailty><geriatric><geriatric medicine><geroscientific><high risk><immune activation><improved><inflammation marker><inflammatory marker><insight><instrumental activity of daily living><long-term study><longitudinal outcome studies><mortality><mtDNA><necrocytosis><neuropsychologic><new marker><novel biomarker><novel marker><older adult><older adulthood><pathophysiology><peer><plasmocyte><pro-aging><progeronic><promote aging><research and methods><sample collection><senior citizen><skills><social role><specimen collection><study design><success><tool><transcriptome sequencing><transcriptomic sequencing><translation research><translational investigation><translational study><urinary><viraemia><viral sepsis><virusemia><wt-loss>
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Katherine Scovner Ravi

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$193,505
FY 2025

Project Title

Association of Dialysate Bicarbonate with Hemodynamic Instability and Arrhythmia

Grant Number:

5K23DK127248-04

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2022

End Date:

6/29/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT This mentored career development award will provide Dr. Katherine Scovner with the resources, additional training and protected time necessary to achieve her goal of becoming an independent clinical investigator. Dr. Scovner has completed her master’s degree in Public Healt...

Research Terms

<Acidosis><Acids><Affect><Arrhythmia><Asystole><Award><Bicarbonates><Biometrics><Biometry><Biostatistics><Blood Pressure><Blood Serum><Bradyarrhythmias><Bradycardia><Cardiac><Cardiac Arrest><Cardiac Arrhythmia><Cardiac Electrophysiologic Techniques><Cardiac Electrophysiological Diagnostics><Cardiology><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cessation of life><Clinical Investigator><Cohort Studies><Complement><Complement Proteins><Complication><Concurrent Studies><Confusion><Confusional State><Cross-Over Trials><Crossover Trials><Data><Death><Death Rate><Development><Dialysis><Dialysis procedure><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><ECG><EKG><ESKD><ESRD><Education><Educational aspects><Electrocardiogram><Electrocardiography><Electrolytes><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Follow-Up Studies><Followup Studies><Foundations><Frequencies><Funding><Future><Goals><HCO3><Heart Arrest><Heart Arrhythmias><Heart Vascular><Hemodiafiltration><Hemodialyses><Hemodialysis><Holter Electrocardiography><Holter Monitoring><Holtmon><Hospitals><Human><Hydrogen Carbonates><Hypotension><Implant><Institution><Investigation><Investigators><K-Awards><K-Series Research Career Programs><Kidney><Kidney Urinary System><Leadership><Life><Low Blood Pressure><Maintenance><Malignant><Malignant - descriptor><Master of Science><Master's Degree><Measures><Medical><Mental Confusion><Mentors><Mentorship><Modern Man><Modification><Monitor><Morbidity><Morbidity - disease rate><Multi-center studies><Multicenter Studies><Myocardial Stunning><Observation research><Observation study><Observational Study><Observational research><Out-patients><Outpatients><Patients><Play><Position><Positioning Attribute><Premature Ventricular Beats><Premature Ventricular Contractions><Public Health><Randomization trial><Randomized><Reporting><Research><Research Career Program><Research Design><Research Personnel><Research Resources><Researchers><Resources><Risk><Role><Sample Size><Science><Serum><Study Type><Stunned Myocardium><Sudden Death><Symptoms><Testing><Time><Training><United States><Vascular Hypotensive Disorder><Ventricular><Ventricular Arrhythmia><Ventricular Ectopic Beats><Ventricular Extrasystole><Ventricular Premature Complexes><Ventricular Premature Complices><Ventricular Tachycardia><Woman><base><bases><cardiac electrophysiology><cardiac rhythm><catalyst><circulatory system><clinical investigation><clinical significance><clinically significant><complementation><conference><convention><developmental><dialysis therapy><experience><heart electrophysiology><heart rhythm><hemodynamics><high risk><improved><innovate><innovation><innovative><mortality><mortality rate><mortality ratio><patient population><prevent><preventing><programs><randomisation><randomization><randomized trial><randomly assigned><renal><responsible research conduct><skill acquisition><skill development><social role><study design><sudden cardiac death><summit><symposia><symposium>
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Neeraj M. Patel

LURIE CHILDREN'S HOSPITAL OF CHICAGO, CHICAGO, IL

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$168,480
FY 2025

Project Title

RED KARD: Reducing Disparities in Knee Arthroscopy for Adolescents

Grant Number:

5K23AR084596-02

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/5/2024

End Date:

6/30/2029

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

The purpose of this K23 proposal is to facilitate Dr. Neeraj Patel’s development into an independent surgeon scientist who will generate patient- and stakeholder-centered input as well as design and implement interventions to reduce delayed care in pediatric sports medicine. Hundreds of thousands of...

Research Terms

<0-11 years old><ACL injury><ACL reconstruction><ACL repair><Acute><Address><Adolescent><Adolescent Youth><Affect><Appointment><Arthritis><Arthroscopy><Athletic><Attitude><Caring><Chicago><Child><Child Youth><Childhood><Childhood Injury><Children (0-21)><Children's Hospital><Clinic><Clinical Trials><Collaborations><Communities><Community Trial><Data><Decrease disparity><Development><Development Plans><Discipline><Education><Educational aspects><Evaluation><Evidence based intervention><Familiarity><Family><Feasibility Studies><Feedback><Female><Focus Groups><Foundations><Frequencies><Funding><Future><Goals><Health Care Systems><Incidence><Injury><Institution><Insurance><International><Intervention><Intervention Community Trial><Interview><Investigators><Knee><Knee Injuries><Knowledge><Language><Lower disparity><Mentors><Mentorship><Methods><Modeling><Operative Procedures><Operative Surgical Procedures><Orthopedic><Orthopedic Surgical Profession><Orthopedics><Parents><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patients><Pediatric Hospitals><Pilot Projects><Population><Process><Publishing><Qualitative Methods><Randomized><Reoperation><Repeat Surgery><Research><Research Design><Research Personnel><Research Resources><Researchers><Resources><Risk><Scientist><Seasons><Soccer><Specialist><Sports><Sports Medicine><Study Type><Surgeon><Surgical><Surgical Interventions><Surgical Procedure><Survey Instrument><Surveys><Testing><Training><Universities><Voice><Work><Youth><Youth 10-21><anterior cruciate ligament injury><anterior cruciate ligament reconstruction><anterior cruciate ligament repair><arthritic><care seeking><career><career development><child health care provider><community advisory board><community advisory committee><community advisory panel><community center><community centers><community engaged participatory research><community engaged research><community partnered research><community research><community-engaged study><community-partnered study><design><designing><developmental><disparity reduction><expectation><experience><female patients><high school><implementation framework><implementation research framework><implementation science><implementation science framework><injured child><injured children><injuries><injury in children><intervention design><juvenile><juvenile human><kids><male><member><mitigate disparity><multidisciplinary><parent><patient centered><patient navigator><patient oriented><patients being female><patients being women><patients who are female><pediatric><pediatric care provider><pediatric health care provider><pediatric injury><pediatric provider><pediatrician><pilot study><population health><prevent><preventing><programs><qualitative reasoning><randomisation><randomization><randomly assigned><reduce disparity><reduction in disparity><study design><surgery><therapy design><treatment design><user centered design><women patients><youngster><youth age><♀><♂>
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Stephanie Nothelle

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$164,569
FY 2025

Project Title

Primary care based collaborative approach to care management for older adults with dementia

Grant Number:

5K23AG072037-05

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

4/15/2021

End Date:

3/31/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Care for the growing population of older adults with Alzheimer's Disease and Related Dementias (ADRD) is challenging. Care management programs are a common approach to streamlining care for persons with conditions such as ADRD. Care management programs are typically siloed in individual settings; ho...

Research Terms

<AD related dementia><ADRD><Accident and Emergency department><Acute><Address><Aging><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Amentia><Area><Baltimore><Behavioral><Bioinformatics><Care Manager><Caring><Case Manager><Clinic><Collaborations><Complex><Comprehensive Health Care><Data><Data Set><Dementia><Development><Discipline><Disease Management><Disorder Management><Emergency Department><Emergency room><Enrollment><Environment><Family Care Giver><Family Caregiver><Fostering><Frequencies><Funding><Future><Goals><Grant><Health><Health system><Heart failure><Hospital Departments><Hospitals><Individual><Intervention><Interview><Investigators><Lead><Link><Managed Care><Managed Care Programs><Managed Health Care Insurance Plans><Matched Group><Medical><Mentors><Older Population><Operative Procedures><Operative Surgical Procedures><Outcome><Pb element><Persons><Prevalence><Primary Care><Publications><Research><Research Methodology><Research Methods><Research Personnel><Research Resources><Researchers><Resources><Role><Scholarship><Scientific Publication><Services><Social support><Specialty><Statistical Methods><Structure><Surgical><Surgical Interventions><Surgical Procedure><Symptoms><Testing><Training Activity><Work><acceptability and feasibility><cardiac failure><care coordination><care delivery><care utilization><career development><co-morbid><co-morbidity><collaborative approach><collaborative care><comorbidity><comprehensive care><coordinating care><dementia care><design><designing><developmental><enroll><experience><feasibility testing><health IT><health information technology><heavy metal Pb><heavy metal lead><improved><intervention design><intervention refinement><managed care insurance><managed care plan><medical specialties><multidisciplinary><novel><older adult><older adulthood><older groups><older individuals><older person><pilot test><population health><primary care clinician><programs><research and methods><social role><social support network><statistic methods><surgery><systematic review><therapy design><training module><treatment design>
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Emily R Hotez

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$156,999
FY 2025

Project Title

Investigating the Role of Chronic Stress and Camouflaging in Obesity Among Autistic Adolescents and Emerging Adults

Grant Number:

1K01DK140611-01A1

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2030

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY / ABSTRACT Autistic individuals, who represent 1 in 36 individuals in the United States, are disproportionately likely to experience obesity relative to the general population. Obesity rates among this group increase during adolescence and emerging adulthood (age 15–30). Chronic stre...

Research Terms

<0-11 years old><12-20 years old><21+ years old><ASD><Address><Adolescence><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Aeroseb-HC><Age><Anxiety><Assay><Autism><Autistic Disorder><BMI><BMI percentile><BMI z-score><Behavior><Behavioral><Bioassay><Biological Assay><Biomedical Research><Body mass index><Cardiovascular Diseases><Cetacort><Child><Child Youth><Children (0-21)><Chronic><Chronic stress><Cognitive><Cognitive Discrimination><Collaborations><Communication><Communities><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Data><Data Collection><Dermacort><Development><Diagnosis><Diagnostic><Discrimination><Distress><Early Infantile Autism><Education><Educational aspects><Effectiveness><Eldecort><Endocrine Gland Secretion><Fats><Fatty acid glycerol esters><Funding><General Population><General Public><Goals><Groups at risk><Hair><Health><Health Care><Hormones><Hydrocortisone><Hydrocortone><Hytone><Individual><Individuals from minority><Individuals of minority><Infantile Autism><Intellectual disability><Intellectual functioning disability><Intellectual limitation><Intelligence><Intervention><Investigators><Kanner's Syndrome><Ketosis-Resistant Diabetes Mellitus><Knowledge><Lead><Leadership><Life Cycle><Life Cycle Stages><Life Style><Lifestyle><Link><Masks><Maturity-Onset Diabetes Mellitus><Measures><Mental Depression><Mentorship><Minority Groups><Minority People><Minority Population><Minority individual><Mission><NIDDK><NIDDM><NIH><National Institute of Diabetes and Digestive and Kidney Diseases><National Institutes of Health><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nutracort><Obesity><Outcome><Pb element><People at risk><Personal Satisfaction><Persons at risk><Population><Populations at Risk><Position><Positioning Attribute><Preparation><Proctocort><QOL><Qualifying><Quality of life><Questionnaire Designs><Questionnaires><Quetelet index><Research><Research Personnel><Research Resources><Researchers><Resources><Risk><Role><Sampling><Self Assessment><Severities><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Stress><Stressful Event><Subgroup><Survey Instrument><Surveys><T2 DM><T2D><T2DM><Testing><Therapeutic Hormone><Training><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><United States National Institutes of Health><Victimization><Waist-Hip Ratio><acceptability and feasibility><adiposity><adolescence (12-20)><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><adult onset diabetes><adult with ASD><adult with autism><adult with autism spectrum disorder><adulthood><adults on the autism spectrum><adults on the spectrum><aged><ages><autism attributes><autism indicator><autism spectral disorder><autism spectrum disorder><autism spectrum disorder features><autism spectrum disorder indicator><autism spectrum disorder symptoms><autism symptomology><autism symptoms><autism-like symptoms><autism-related attributes><autistic><autistic adolescent><autistic adult><autistic features><autistic individuals><autistic people><autistic spectrum disorder><autistic symptoms><autistic traits><autistic youth><autistic-like symptoms><biological adaptation to stress><cardiovascular disorder><clinical heterogeneity><corpulence><depression><developmental><early adulthood><emerging adult><emerging adulthood><experience><food Ingestion><food consumption><heavy metal Pb><heavy metal lead><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><intellectual and developmental disability><ketosis resistant diabetes><kids><life course><limited intellectual functioning><marginalized group><marginalized individual><marginalized people><marginalized population><maturity onset diabetes><mortality><multi-modality><multimodality><obesigenic><obesity intervention><obesity therapy><obesity treatment><obesogenic><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><pilot test><preparations><reactioncrisis><recruit><self esteem><skills><social><social role><social stigma><stigma><stress response><stressreaction><stressful experience><stressful life event><stressful life experience><stressor><suicidal><suicidality><type 2 DM><type II DM><type two diabetes><waist-to-hip ratio><well-being><wellbeing><youngster><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder>
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Lili Liu

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$152,680
FY 2025

Project Title

Uncovering novel mechanisms and potential therapeutic targets for IgA vasculitis through GWAS and systems-level analysis of regulatory networks.

Grant Number:

5K01DK137031-03

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/24/2023

End Date:

5/31/2028

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT IgA vasculitis (IgAV) is the most common form of systemic vasculitis in children, characterized by IgA deposition in the small blood vessels of skin, kidney, gastrointestinal tract, and joints. Among patients with IgAV, 20%-55% have renal involvement. Renal manifestations in...

Research Terms

<0-11 years old><19q13><1q21><21+ years old><2q37.1><Actemra><Address><Adult><Adult Human><Affect><Alimentary Canal><Allergic Purpura><Anaphylactoid Purpura><Angiitis><Asian ancestry><Asian descent><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Award><Blood><Blood Reticuloendothelial System><Blood Vessels><CD126 Antigens><CD126 Receptor><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Child><Child Youth><Childhood><Children (0-21)><Chromosome Mapping><Clinical><Clinical Data><Communicable Diseases><Complex Genetic Trait><Data><Data Set><Deposit><Deposition><Detection><Development><Digestive Tract><Disease><Disorder><ESKD><ESRD><East Asian><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Ethnic Origin><Ethnicity><European><Foundations><Funding><GI Tract><GWA study><GWAS><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Action Regulation><Gene Expression><Gene Expression Regulation><Gene Localization><Gene Mapping><Gene Mapping Genetics><Gene Regulation><Gene Regulation Process><Gene Splicing><Gene variant><Genes><Genetic><Genetic Determinism><Genetic Medicine><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Genetic study><Genomics><Goals><HLA-DRB1><HLA-DRB1 antigen><Health><Hematuria><Henoch-Schoenlein Purpura><Henoch-Scholein purpura><Henoch-Schonlein Purpura><Human><Human Genetics><IL-6 Receptors><IL6 Receptors><IgA><IgA FcR><IgA receptor><IgA vasculitis><Iga vasculitis with nephritis><Immune><Immune Targeting><Immunes><Immunochemical Immunologic><Immunoglobulin A><Immunologic><Immunological><Immunologically><Immunologics><Individual><Infectious Diseases><Infectious Disorder><Inflammatory><Inherited Predisposition><Inherited Susceptibility><Interleukin 6 Receptor><Intracellular Communication and Signaling><Investigators><Joints><K-Awards><K-Series Research Career Programs><Kidney><Kidney Diseases><Kidney Failure><Kidney Insufficiency><Kidney Urinary System><Knowledge><Linkage Mapping><Maps><Mediating><Mentors><Mentorship><Meta-Analysis><Modeling><Modern Man><Molecular Medicine><Multiomic Data><Nephrology><Nephropathy><Organ><Outcome><Pathogenesis><Pathogenicity><Pathway interactions><Patients><Population Analysis><Predisposition gene><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Proteinuria><Proteome><QTL><Quantitative Trait Loci><RNA Splicing><Regulator Genes><Renal Disease><Renal Failure><Renal Insufficiency><Research><Research Career Program><Research Personnel><Research Resources><Research Training><Researchers><Resources><Risk><Risk-associated variant><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Spliced Genes><Splicing><Susceptibility Gene><System><Systems Biology><Testing><Total Human and Non-Human Gene Mapping><Training><Transcriptional Regulatory Elements><Translations><Universities><Variant><Variation><Vasculitis><Work><adulthood><alimentary tract><allelic variant><autoimmune condition><autoimmune disorder><autoimmunity disease><biological signal transduction><career><career development><case control><case-controlled><causal allele><causal gene><causal mutation><causal variant><causative mutation><causative variant><cell type><cohort><developmental><digestive canal><drug development><drug repositioning><drug repurposing><functional genomics><gene function><gene regulatory network><genetic analysis><genetic architecture><genetic determinant><genetic etiology><genetic mapping><genetic mechanism of disease><genetic trans acting element><genetic variant><genetic vulnerability><genetically predisposed><genome scale><genome wide association><genome wide association scan><genome wide association study><genome-wide><genomewide><genomewide association scan><genomewide association study><genomic variant><global gene expression><global transcription profile><immunoglobulin A Fc receptor><immunoglobulin A receptor><improved><insight><kidney disorder><kids><multidisciplinary><multiple omic data><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><pediatric><peripheral blood><population based><precision medicine><precision-based medicine><predisposing gene><prevent><preventing><reconstruction><regulatory gene><renal><renal disorder><repurposing agent><repurposing medication><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><skill acquisition><skill development><susceptibility allele><susceptibility locus><susceptibility variant><therapeutic target><tocilizumab><trait><trans acting element><transcriptome><transcriptomics><translation><treatment strategy><vascular><vasculitides><whole genome association analysis><whole genome association study><youngster>
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Anna Santoro

BETH ISRAEL DEACONESS MEDICAL CENTER, BOSTON, MA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$150,736
FY 2025

Project Title

Mechanisms for the regulation of novel lipids in vivo

Grant Number:

5K01DK128075-05

Activity Code:

K01

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2021

End Date:

5/31/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Project Summary/Abstract: Research: Insulin resistance is a major cause for type 2 Diabetes (T2D) and is implicated in many life- threatening complications of T2D. A better understanding of the molecular mechanisms for insulin resistance is essential to develop potent and safe insulin sensitizers, w...

Research Terms

<Academia><Address><Adipocytes><Adipose Cell><Adipose tissue><Adult-Onset Diabetes Mellitus><Advisory Committees><Anabolism><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-diabetic Agents><Anti-diabetic Drugs><Anti-inflammatory><Assay><Binding Proteins><Bioassay><Bioinformatics><Biological Assay><Biopsy><Blood Serum><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Carbohydrates><Cas nuclease technology><Causality><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Computer Models><Computerized Models><DNA Molecular Biology><Data><Data Set><Development><Development Plans><Diabetes Mellitus><Dihydrooleic Acids><Down-Regulation><Drugs><Economic Burden><Endocrine><Environment><Enzyme Gene><Enzymes><Esters><Etiology><Experimental Designs><Fasting><Fat Cells><Fatty Tissue><Funding><Future><GLUT 4 protein><GLUT4><GLUT4 gene><GLUT4 protein><Genes><Genetic><Genetic Diversity><Genetic Models><Genetic Variation><Genomic Segment><Glucose Binding Protein><Glucose Transport Protein><Glucose Transporter><Goals><Grant><Hepatic><Hexadecanoic Acid><High Fat Diet><Human><Humulin R><Hydrolysis><Hydroxy Acids><Individual><Infusion><Infusion procedures><Insulin><Insulin Resistance><Intermediary Metabolism><Investigators><Isotopes><K01 Award><K01 Mechanism><K01 Program><KO mice><Ketosis-Resistant Diabetes Mellitus><Knock-out Mice><Knockout Mice><Label><Life><Ligand Binding Protein><Ligand Binding Protein Gene><Lipids><Lipocytes><Mammalian Cell><Maps><Mature Lipocyte><Mature fat cell><Maturity-Onset Diabetes Mellitus><Measures><Mediating><Mediation><Medication><Mentored Research Scientist Development Award><Mentored Training Award><Mentorship><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Pathway><Metabolic Processes><Metabolism><Methods><Mice><Mice Mammals><Modern Man><Molecular><Molecular Biology><Mouse Strains><Murine><Mus><NIDDM><NIH><National Institutes of Health><Negotiating><Negotiation><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Novolin R><Null Mouse><Obese Mice><Obesity><Octadecanoic Acids><Palmitic Acids><Pathway interactions><Periodicals><Persons><Pharmaceutical Preparations><Phenotype><Physiologic><Physiological><Population><Preparation><Process><Protein Binding><Protocol><Protocols documentation><QTL><Quantitative Trait Loci><RNA Seq><RNA sequencing><RNAseq><Regular Insulin><Regulation><Research><Research Personnel><Research Scientist Development Award><Researchers><Response Elements><Role><Scientist><Serum><Site><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Stearic Acids><T2 DM><T2D><T2DM><Task Forces><Technology><Testing><Tetrahydrolinoleic Acids><Therapeutic><Thesaurismosis><Tissues><Training><Triacylglycerol><Triglycerides><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States National Institutes of Health><Variant><Variation><adipogenesis><adipose><adiposity><adult onset diabetes><advisory team><anti-diabetic><biosynthesis><blood glucose regulation><bound protein><candidate identification><career><career development><causation><computational modeling><computational models><computer based models><computerized modeling><corpulence><developmental><diabetes><disease causation><drug/agent><enzyme biosynthesis><fasted><fasts><fat metabolism><feeding><genome segment><genomic region><glucose control><glucose homeostasis><glucose regulation><glucose tolerance><hydroxyacid><improved><in vivo><infusions><innovate><innovation><innovative><insight><insulin resistant><insulin sensitivity><insulin sensitizer><insulin sensitizing drugs><insulin tolerance><insulin-responsive glucose transporter><interest><ketosis resistant diabetes><knockout gene><lipid biosynthesis><lipid metabolism><lipidomics><lipogenesis><maturity onset diabetes><meeting><meetings><metabolism disorder><metabolism measurement><metabolomics><metabonomics><mouse model><multiomics><multiple omics><murine model><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><ob/ob mouse><overexpress><overexpression><panomics><pathway><periodic><periodical><post-doctoral training><preparations><prevent><preventing><programs><skills><social><social role><trait><transcriptome sequencing><transcriptomic sequencing><translational study><type 2 DM><type II DM><type two diabetes><white adipose tissue><yellow adipose tissue>
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Katherine Scovner Ravi

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 36/100
Training-friendly
Active award
Career award
$75,600
FY 2025

Project Title

Association of Dialysate Bicarbonate with Hemodynamic Instability and Arrhythmia

Grant Number:

3K23DK127248-04S1

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

7/1/2022

End Date:

6/29/2027

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

PROJECT SUMMARY/ABSTRACT This mentored career development K23 award is providing Dr. Katherine Scovner Ravi with the resources, additional training and protected time necessary to achieve her goal of becoming an independent clinical investigator. Dr. Ravi has completed her master’s degree in public...

Research Terms

<Affect><Arrhythmia><Award><Bicarbonates><Biometrics><Biometry><Biostatistics><Blood Serum><Cardiac><Cardiac Arrhythmia><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Clinical Investigator><Complement><Complement Proteins><Data><Death Rate><Dialysis><Dialysis procedure><Double-blind trial><ECG><EKG><ESKD><ESRD><Education><Educational aspects><Electrocardiogram><Electrocardiography><Electrolytes><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Funding><Future><Goals><HCO3><Heart Arrhythmias><Heart Vascular><Hemodialyses><Hemodialysis><Hospitals><Hydrogen Carbonates><Hypotension><Implant><Institution><Investigation><K-Awards><K-Series Research Career Programs><K23 Award><K23 Mechanism><K23 Program><Leadership><Life><Low Blood Pressure><Maintenance><Master of Science><Master's Degree><Measures><Medical><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentors><Mentorship><Monitor><Morbidity><Morbidity - disease rate><Patients><Play><Public Health><Publishing><Randomized><Research><Research Career Program><Research Design><Research Resources><Resources><Risk><Role><Science><Serum><Study Type><Time><Training><United States><Vascular Hypotensive Disorder><Ventricular><Woman><cardiac rhythm><career development><catalyst><circulatory system><clinical investigation><clinical significance><clinically significant><cohort><complementation><conference><convention><dialysis therapy><experience><heart rhythm><hemodynamics><improved><mortality><mortality rate><mortality ratio><prevent><preventing><programs><randomisation><randomization><randomly assigned><recruit><responsible research conduct><skill acquisition><skill development><social role><study design><sudden cardiac death><summit><symposia><symposium>
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Caroline Rose Szczepanski

MICHIGAN STATE UNIVERSITY, EAST LANSING, MI

Exploratory lead · 32/100
Solid budget
Recent
Active award
$298,613
FY 2026

Project Title

Uncovering interactions between bioderived nanomaterials and water in novel dental adhesives: strategies for reduced moisture sensitivity

Grant Number:

1R03DE035537-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/29/2028

Project Abstract

Project Summary The overarching goal of this R03 proposal is reduce the moisture sensitivity of dental adhesives by incorporating cellulose nanocrystals (CNCs). This work is motivated by prior research in related engineering applications (e.g., pressure sensitive adhesives, coatings) demonstrating t...

Research Terms

<Acceleration><Address><Adhesives><Agriculture><Area><Award><Benign><Binding><Binding Sites><Biocompatible Materials><Biomaterials><Body Tissues><Caries><Cellulose><Chemistry><Clinical><Collagen><Combining Site><Communities><Complex><Data><Dental Decay><Dental Enamel><Dental Materials><Dental Models><Dental caries><Dentin><Dentistry><Diet><Diffusion><Enamel><Engineering><Environment><Event><Exposure to><Failure><Food Packaging><Foundations><Future><Geometry><Goals><Health Care><Heterogeneity><Hydrogen Oxide><Hydrolysis><Hydroxyl><Hydroxyl Radical><Individual><Infection><Investigation><Lead><Length of Life><Longevity><Mediating><Methacrylates><Microbial Biofilms><Modeling><Modulus><Molecular Interaction><Motivation><Nature><Oral><Oral health><Outcome><Pb element><Performance><Phase><Plant Resins><Polyanhydroglucuronic Acid><Polymers><Predisposition><Property><Qualifying><R-Series Research Projects><R01 Mechanism><R01 Program><Reactive Site><Research><Research Grants><Research Project Grants><Research Projects><Secondary to><Site><Solvents><Source><Structure><Surface><Susceptibility><System><Testing><Tissues><Tooth><Tooth structure><Translating><Variant><Variation><Water><Wood><Wood material><Work><adhesive polymer><alpha-Cellulose><aqueous><biofilm><biological material><biological systems><career><composite restoration><copolymer><covalent bond><demineralization><dental adhesive><dental health><design><designing><diets><diffused><diffuses><diffusing><diffusions><heavy metal Pb><heavy metal lead><improved><innovate><innovation><innovative><life span><lifespan><mechanical properties><monomer><nano><nanocrystal><nanomaterials><next generation><novel><photopolymerization><polymer><polymeric><pressure><prevent><preventing><resin><response><restoration><teeth><tooth decay><tooth enamel><uptake>
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Venee N Tubman

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Exploratory lead · 30/100
Very recent
Active award
$240,707
FY 2026

Project Title

Mechanisms of Marginal Zone Depletion in Sickle Cell Spleen Tissue

Grant Number:

1R03HL183274-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Sickle cell disease (SCD) is a devastating inherited hemolytic anemia that affects millions of people worldwide. Over 500,000 infants are born with SCD annually and the majority die before 5 years of age due to spleen dysfunction. In studies conducted with my K23 award, we determined...

Research Terms

<0-11 years old><5 year old><5 years of age><Ab response><Affect><Antibody Formation><Antibody Production><Antiheparin Factor><Autoantigens><Autoimmune Status><Autoimmunity><Autologous Antigens><Award><B blood cells><B cell><B cell differentiation><B cell differentiation factor><B cell stimulating factor 2><B cells><B lymphocyte differentiation><B-Cell Activation><B-Cell Development><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><B-Cell Subsets><B-Cells><B-Lymphocyte Subsets><B-Lymphocytes><B-cell><BCDF><BSF-2><BSF2><Blood><Blood Platelet Factor IV><Blood Reticuloendothelial System><Blood Serum><Blood platelet factor 4><Body Tissues><CD34><CD34 gene><CX(3)C protein><CX3CR1 gene><Cell Body><Cell Communication and Signaling><Cell Count><Cell Number><Cell Signaling><Cells><Chemokine (C-X-C motif) Ligand 4><Chemokine (C-X3-C Motif) Ligand 1><Child><Child Youth><Children (0-21)><Clinical><Data><Development><Disease><Disorder><Dysfunction><ELISA><Enzyme-Linked Immunosorbent Assay><FKN protein><Factor 4><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Fractalkine><Fractalkine Receptor CX3CR1><Functional disorder><Funding><Future><G Protein-Coupled Receptor 13><G Protein-Coupled Receptor V28><GPR13><Gene Expression><Genes><Goals><HPCA1><HPGF><Hb SS disease><HbSS disease><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hemolysis><Hemolytic Anemia><Heparin Neutralizing Protein><Hepatocyte-Stimulating Factor><Hereditary><Histopathology><Human><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-21 receptor><IL-6><IL21><IL21R><IL6 Protein><Image><Immune><Immune Diseases><Immune Disorders><Immune Dysfunction><Immune System Diseases><Immune System Disorder><Immune System Dysfunction><Immune System and Related Disorders><Immunes><Immunologic Diseases><Immunological Diseases><Immunological Dysfunction><Immunological System Dysfunction><Impairment><Infant><Infection><Inflammatory><Inherited><Interleukin-6><Intracellular Communication and Signaling><K23 Award><K23 Mechanism><K23 Program><Knowledge><Life><Ligands><MGI-2><Marginal Zone B-Lymphocyte><Measures><Memory B Cell><Memory B-Lymphocyte><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mice><Mice Mammals><Modeling><Modern Man><Modification><Murine><Mus><Myeloid Differentiation-Inducing Protein><PF4 Gene><Pathway interactions><Patients><Persons><Physiopathology><Plasmacytoma Growth Factor><Platelet Factor 4><Pluripotent Stem Cells><Population><Production><Progenitor Cells><RNA Seq><RNA sequencing><RNAseq><Recombinant Platelet Factor 4><Research><Role><SCYB4><Sampling><Self-Antigens><Serum><Sickle Cell><Sickle Cell Anemia><Signal Transduction><Signal Transduction Systems><Signaling><Small Inducible Cytokine B4><Small Inducible Cytokine D1><Small Inducible Cytokine Subfamily B, Member 4><Sorting><Spleen><Spleen Reticuloendothelial System><Stimulus><System><Testing><Tissue Sample><Tissues><V28><activated B cells><adaptive immunity><age 5><age 5 years><age associated decline><age dependent decline><age related decline><antibody biosynthesis><autoimmune reactivity><autoreactivity><biological signal transduction><decline with age><developmental><differentiation factors><enzyme linked immunoassay><erythrolysis><five year old><five years of age><flow cytophotometry><gamma-Thromboglobulin><imaging><immunoglobulin biosynthesis><improved outcome><in vivo><infection risk><injury to organs><interferon beta 2><interleukin-21><interleukin-21 receptor><kids><morphogenic factors><morphogens><mouse model><murine model><novel><organ injury><pathogen><pathophysiology><pathway><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><peripheral blood><platelet factor IV><pluripotent progenitor><prevent><preventing><response><sickle RBC><sickle cell disease><sickle cell disorder><sickle disease><sickle erythrocyte><sickle red blood cell><sicklemia><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><stem cells><tool><transcriptome sequencing><transcriptomic sequencing><transcriptomics><youngster>
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Linda Jones Herbert

CHILDREN'S RESEARCH INSTITUTE, WASHINGTON, DC

Exploratory lead · 30/100
Very recent
Active award
$182,000
FY 2026

Project Title

Caregiver Beliefs and Psychosocial Experiences Related to Emerging Treatment Options for Children with Food Allergy

Grant Number:

1R03AI190490-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY / ABSTRACT The goals of this R03 Award are to 1) identify food allergy beliefs and perceived treatment benefits/burdens among caregivers of children who pursue Xolair food allergy treatment and 2) determine the relationship of the uptake of Xolair food allergy treatment and caregiver...

Research Terms

<0-11 years old><5 year old><5 years of age><Accidents><Address><Advocate><Affect><Allergens><Allergic Reaction><Allergic to food><Allergy><Allergy to food><Anaphylactic Reaction><Anaphylactic Shock><Anaphylaxis><Anxiety><Award><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Belief><Binding><Care Givers><Care giver support><Caregiver support><Caregivers><Child><Child Youth><Children (0-21)><Clinic><Clinical><Clinical Treatment Moab><Clinical Trials><Conditioning Therapy><Data><Decision Making><Diagnosis><Diet><Distress><Evidence based program><FDA approved><Family><Fear><Food><Food Allergy><Food Hypersensitivity><Fright><Goals><Guidelines><Home><IgE><Immune response><Immunoglobulin E><Injections><Interview><Life><Measures><Mediator><Modeling><Molecular Interaction><Monoclonal Antibodies><Oral><Pain><Painful><Pattern><Perception><Personal Satisfaction><Pilot Projects><Population><Predisposition><Process><Provider><Public Health><QOL><QOL improvement><Quality of life><Reaction><Reporting><Research><Stress><Subcutaneous Injections><Survey Instrument><Surveys><Susceptibility><Treatment Protocols><Treatment Regimen><Treatment Schedule><United States><Xolair><age 5><age 5 years><anaphylactic response to food><anaphylaxis caused by food><anaphylaxis due to food><anaphylaxis to food><anxiety reduction><behavior intervention><behavioral health><behavioral intervention><care providers><clinical development><diets><education resources><educational resources><experience><family support><five year old><five years of age><follow-up investigation><follow-up research><food allergen><food allergy anaphylaxis><food anaphylactic reaction><food anaphylaxis><food associated anaphylaxis><food challenge><food induced anaphylaxis><food mediated anaphylaxis><food related anaphylaxis><food triggered anaphylaxis><health belief><health-related belief><homes><host response><immune system response><immunoresponse><improvements in QOL><improvements in quality of life><investigate follow-up><kids><mAbs><monoclonal Abs><multi-site trial><multisite trial><omalizumab><oral immunotherapy><pilot study><prevent><preventing><psychosocial><quality of life improvement><recruit><response><shared decision making><study follow-up><subdermal injection><survey follow-up><uptake><well-being><wellbeing><youngster>
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Erin D. Gordon

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 30/100
Very recent
Active award
$174,824
FY 2026

Project Title

Development of a Humanized IL33 Mouse

Grant Number:

1R03AI190673-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/6/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY: In this R03 application, “Development of a Humanized IL33 Mouse” we plan to engineer and characterize a mouse strain in which the human IL33 gene sequence from ~28 kb (including the 20 kb asthma-associated region) upstream of exon 1 to ~21 kb downstream of exon 8 of human IL33 gene ...

Research Terms

<Abscission><Acute><Affect><Air Movements><Allergens><Allergic Disease><Alveolar Cell><Anatomic Sites><Anatomic structures><Anatomy><Architecture><Area><Aspergillus><Asthma><Automobile Driving><BAC clone><BACs><Back><Bacterial Artificial Chromosomes><Basement membrane><Basophilic Granulocyte><Basophils><Biological><Biology><Blood Basophil><Body Tissues><Bronchial Asthma><COPD><Cell Body><Cells><Cherry - dietary><Chronic Bronchitis><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical Treatment Moab><Code><Coding System><DNA><Deoxyribonucleic Acid><Development><Disease><Disorder><Distal><Dorsum><Drugs><Endothelium><Engineering><Engineering / Architecture><Enhancer Elements><Epithelial Cells><Escalator><Excision><Exons><Extirpation><Family><Future><GWA study><GWAS><Gases><Gene Expression><Genes><Genetic Enhancer Element><Goblet Cells><Human><Human Activities><Human Genetics><Human Genome><IL-1><IL1><IRES><Immune infiltrates><Immunity><Immunochemical Immunologic><Immunologic><Immunological><Immunologically><Immunologics><Immunology><Infiltration><Inflammation><Inflammatory><Inflammatory Infiltrate><Inhalation><Inhaling><Interleukin I><Interleukin-1><Internal Ribosome Entry Segment><Internal Ribosome Entry Site><Intervening Sequences><Introns><Knock-in><Knock-out><Knockout><Location><LoxP-flanked allele><Lung><Lung Alveolar Epithelia><Lung Diseases><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lymphocyte-Stimulating Hormone><Macrophage Cell Factor><Marrow Mast Cell><Medication><Mice><Mice Mammals><Modeling><Modern Man><Monoclonal Antibodies><Mouse Strains><Mucous body substance><Mucus><Murine><Mus><Nucleic Acid Regulator Regions><Nucleic Acid Regulatory Sequences><Obstructive Lung Diseases><Pathologic><Patients><Pattern><Pharmaceutical Preparations><Phenotype><Production><Proteins><Pulmonary Body System><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Organ System><Regulatory Element><Regulatory Regions><Removal><Reporter><Reporting><Research><Respiratory Epithelium><Respiratory System><Respiratory Tracts><Respiratory tract structure><Ribosome Entry Site><Risk-associated variant><Role><Scientist><Site><Stromal Cells><Structure of parenchyma of lung><Structure of respiratory epithelium><Surgical Removal><T Helper Factor><Technology><Testing><Th-2 Cell><Th2 Cells><Tissue Basophils><Tissues><Transgenes><Treatment Efficacy><Type 2 Helper Cell><Wild Type Mouse><Work><air flow><airflow><airflow limitation><airflow obstruction><airway epithelium><airway limitation><airway obstruction><alveolar epithelium><biologic><bronchial epithelium><cell type><cherries><chronic obstructive pulmonary disorder><clinical relevance><clinically relevant><cytokine><developmental><disease of the lung><disorder of the lung><driving><drug/agent><enhancer sequence><ex-smoker><floxed><floxed allele><former smoker><genetic architecture><genetic enhancer sequence><genetic regulatory element><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><human whole genome><immune cell infiltrate><intervention efficacy><knockin><lung disorder><lung health><lymphocyte activating factor><mAbs><mast cell><mastocyte><monoclonal Abs><mouse model><mucous><murine model><novel><obstructed airflow><obstructed airway><obstructive pulmonary diseases><particle><phase 2 study><phase II study><promoter><promotor><pulmonary health><resection><respiratory airway obstruction><respiratory tract epithelium><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><site-specific integration><smoking-induced lung disease><smoking-related lung disease><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><therapeutic efficacy><therapy efficacy><transgene><whole genome association analysis><whole genome association study><wildtype mouse>
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Michael W Curtis

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Exploratory lead · 30/100
Very recent
Active award
$160,500
FY 2026

Project Title

Development of a novel Guinea pig model that mimics human relapsing fever disease.

Grant Number:

1R03AI196485-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Project Summary Relapsing fever (RF) Borrelia are vector-borne pathogens that cause severe clinical manifestations. While RF Borrelia can be transmitted by lice and hard ticks, soft ticks transmit most RF Borrelia species. The unique biology of soft ticks causes concerns for future RF outbreaks. Whi...

Research Terms

<21+ years old><Acute><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Animals><Antibiotic Agents><Antibiotic Drugs><Antibiotic Therapy><Antibiotic Treatment><Antibiotics><Antigen Variation><Antigenic Variability><Antigenic Variation><Argasidae><B turicatae><B. turicatae><Biology><Blood><Blood Reticuloendothelial System><Body Measures><Body Temperature><Body Tissues><Body Weight decreased><Body measure procedure><Borrelia><Borrelia Infections><Borrelia turicatae><Breeding><Cavia><Cell Body><Cells><Cessation of life><Childhood><Clinical><Communicable Diseases><Death><Development><Diagnostic Findings><Disease><Disease Outbreaks><Disorder><Doxycycline><Ecdysis><Fever><Fever Therapy><Follow-Up Studies><Future><Goals><Guinea Pigs><Guinea Pigs Mammals><Hard Ticks><Hardbacked Ticks><Health><Hour><Human><Hyperthermia><Immune><Immune response><Immunes><Incubated><Induced Hyperthermia><Infection><Infectious Diseases><Infectious Disorder><Inflammatory><Intervention Studies><Ixodid ticks><Ixodida><Ixodidae><Lead><Lice><Life><Mice><Mice Mammals><Miscellaneous Antibiotic><Mission><Modeling><Modern Man><Molting><Morbidity><Mothers><Murine><Mus><NIAID><National Institute of Allergy and Infectious Disease><Neurologic><Neurological><North America><Order Spirochaetales><Ornithodoros><Outbreaks><Outcome><Pathogenesis><Pathology><Patients><Pb element><Perinatal Mortalities><Perinatal lethality><Perinatal mortality demographics><Phthiraptera><Pregnancy Complications><Production><Proteins><Pyrexia><Reaction><Recurrence><Recurrent><Relapsing Fever><Relapsing Fever Ticks><Signs and Symptoms><Soft Ticks><Softbacked Ticks><Spirochaetales><Spirochetes><Symptoms><System><Testing><Therapeutic Hyperthermia><Thermotherapy><Tick-Borne Relapsing Fever><Ticks><Tissues><Toxin><Transmission><Vibramycin><Weight Loss><Weight Reduction><Weights and Measures><Work><adulthood><alpha-6-Deoxyoxytetracycline><bacterial disease treatment><bacterial infectious disease treatment><body weight loss><borrelial><borreliosis><complications during pregnancy><cost effective><cytokine><developmental><disease model><disorder model><experience><febrile><febris><follow-up research study><follow-up survey><guinea pig model><hard-bodied ticks><heavy metal Pb><heavy metal lead><host response><human disease><human model><immune system response><immunoresponse><intervention research><interventional research><interventional study><interventions research><life span><lifespan><model of animal><model of human><mouse model><murine model><neglect><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-human primate><nonhuman primate><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><offspring><pathogen><pediatric><perinatal deaths><pregnancy-related complications><prevent><preventing><relapsing fever borrelia><response><soft bodied tick><study with follow-up><subcutaneous><subdermal><therapeutic agent development><therapeutic development><tick mediated transmission><tick transmission><tick transmitted><tickborne relapsing fever><transmission process><vector><vector-borne pathogen><vectorborne pathogen><wt-loss>
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BRENT J. RYCKMAN

UNIVERSITY OF MONTANA, MISSOULA, MT

Exploratory lead · 30/100
Very recent
Active award
$147,000
FY 2026

Project Title

Inter-strain recombinants of human cytomegalovirus as an in vitro model of in vivo genetic diversity.

Grant Number:

1R03AI195988-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/6/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

Pathogen genetic diversity presents an obstacle to effective interventions against infectious diseases. The development of drugs and vaccines often rely on in vitro models that poorly reflect the real-world genetic diversity of the pathogen. This is the case for human cytomegalovirus (HCMV), which d...

Research Terms

<0-11 years old><21+ years old><3C-based approach><3C-based assay><3C-based method><3C-based strategy><3C-based technique><3C-based technology><Adult><Adult Human><Alleles><Allelomorphs><Amino Acids><Anti-viral Agents><BAC clone><BACs><Bacterial Artificial Chromosomes><CMV><CMV infection><Cell Body><Cells><Child><Child Youth><Children (0-21)><Communicable Diseases><Complex><Crossing Over><Cytomegalic Inclusion Disease><Cytomegalovirus><Cytomegalovirus Infections><DNA Alteration><DNA Molecular Biology><DNA Recombination><DNA Sequence Alteration><DNA crossover><Development><Drugs><Epistasis><Epistatic Deviation><Failure><Future><Genes><Genetic><Genetic Alteration><Genetic Crossing Over><Genetic Diversity><Genetic Epistasis><Genetic Recombination><Genetic Variation><Genome><Genomics><Glycoproteins><Goals><HCMV><Haplotypes><Human><Human Biology><Immunocompromised><Immunocompromised Host><Immunocompromised Patient><Immunosuppressed Host><In Vitro><Inclusion Disease><Individual><Infection><Infectious Diseases><Infectious Disorder><Interaction Deviation><Intervention><Investments><Left><Libraries><Linkage Disequilibrium><Medication><Modeling><Modern Man><Modernization><Molecular Biology><Other Genetics><Pattern><Persons><Pharmaceutical Preparations><Phenotype><Point Mutation><Prevention><Privatization><Publishing><RFLP><Recombinant Haplotype><Recombinants><Recombination><Research><Resolution><Restriction Fragment Length Polymorphisms Molecular Biology><Restriction fragment length polymorphism><Role><Salivary Gland Virus Disease><Salivary Gland Viruses><Sequence Alteration><Side><System><Vaccines><Variant><Variation><Viral><Viral Genes><adulthood><aminoacid><anti-viral compound><anti-viral drugs><anti-viral medication><anti-viral therapeutic><anti-virals><chromatin conformation capture><chromosome capture><chromosome conformation capture><co-infection><coinfection><comparative><crossover recombination><cytomegalovirus group><develop therapy><developmental><drug development><drug/agent><effective intervention><epistatic interaction><epistatic relationship><gene x gene interaction><genetic epistases><genome scale><genome-wide><genomewide><genomic alteration><genomic crossover><human model><immunosuppressed patient><in vitro Model><in vivo><in vivo Model><innovate><innovation><innovative><inter-homolog crossover><intervention development><kids><meiotic crossover><model development><model developments><model of human><neutralizing antibody><non-sister chromatid exchange><nonsister chromatid exchange><pathogen><preference><resolutions><social role><therapy development><treatment development><youngster>
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Lily S Cheng

UNIVERSITY OF VIRGINIA, CHARLOTTESVILLE, VA

Exploratory lead · 30/100
Very recent
Active award
$121,125
FY 2026

Project Title

Engineering a gut-on-chip model to study biomechanical forces on the enteric nervous system

Grant Number:

1R03DK144289-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Chronic idiopathic constipation is a functional gastrointestinal disorder that affects up to 1 in 5 children. As a pediatric surgeon, often the only effective treatments I can offer are intestinal resection or diversion. Thus, I strive to better understand the mechanisms that result...

Research Terms

<0-11 years old><21+ years old><3-D><3-Dimensional><3D><Abscission><Adult><Adult Human><Affect><Aganglionic Megacolon><Alimentary Canal><American><Behavior><Biologic Models><Biological Models><Biomechanics><Body Tissues><CNS Nervous System><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Communication and Signaling><Cell Culture Techniques><Cell Signaling><Cell Therapy><Cellular biology><Central Nervous System><Child><Child Youth><Childhood><Children (0-21)><Chronic><Clinical Investigator Award><Co-culture><Cocultivation><Coculture><Coculture Techniques><Congenital Megacolon><Constipation><Data><Digestive Tract><Disease><Disorder><Dysfunction><Engineering><Enteral><Enteric><Enteric Nervous System><Environment><Excision><Exhibits><Extirpation><Fluorescence Activated Cell Sorting Fractionation><Fluorescence-Activated Cell Sorting><Fluorescence-Activated Cell Sortings><Foundations><Functional Gastrointestinal Disorders><Functional disorder><Future><GI Tract><Gastrointestinal Diseases><Gastrointestinal Motility><Gastrointestinal Tract><Gastrointestinal tract structure><Gene Modified><Glia><Glial Cells><Goals><Hirschsprung Disease><Hospitals><In Vitro><Individual><Intestinal><Intestines><Intracellular Communication and Signaling><Investigators><Ion Channel><Ionic Channels><K-Awards><K-Series Research Career Programs><K08 Mechanism><K08 Program><Knowledge><Kolliker's reticulum><Lead><Location><Measures><Mechanics><Mechanoreceptors><Mediating><Mediator><Membrane Channels><Methodology><Methods><Mice><Mice Mammals><Microfluidics><Model System><Modeling><Molecular><Molecular Biology Techniques><Morphology><Murine><Mus><Nerve Cells><Nerve Unit><Nervous System Physiology><Neural Cell><Neural Stem Cell><Neuraxis><Neurocyte><Neuroglia><Neuroglial Cells><Neurologic function><Neurological function><Neurons><Non-neuronal cell><Nonneuronal cell><Paracrine Communication><Paracrine Signaling><Pathogenesis><Pathologic><Patients><Pb element><Phenotype><Physicians><Physiologic><Physiological><Physiology><Physiopathology><Piezo 1><Piezo 1 ion channel><Piezo1><Play><QOL improvement><Removal><Research Career Program><Research Methodology><Research Methods><Research Personnel><Researchers><Role><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Stress><Stretching><Structure><Surgeon><Surgical Removal><System><Testing><Time><Tissues><United States><Visit><Work><adulthood><aganglionosis><alimentary tract><biological signal transduction><biomechanical><bowel><cell based intervention><cell biology><cell culture><cell cultures><cell mediated intervention><cell mediated therapies><cell type><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><child patients><chip model><chip system><digestive canal><dysmotility><dysmotility syndrome><effective therapy><effective treatment><gastrointestinal><gastrointestinal disorder><gastrointestinal function><gene modification><genetically modified><heavy metal Pb><heavy metal lead><improvements in QOL><improvements in quality of life><in vitro Model><in vivo Model><innovate><innovation><innovative><kids><life span><lifespan><mechanic><mechanical><mechanical drive><mechanical properties><micro-fluidic system><microfluidic platform><microfluidic technology><motility disorder><mouse model><murine model><nerve cement><nerve stem cell><nervous system function><neural precursor><neural precursor cell><neural progenitor><neural progenitor cells><neural stem and progenitor cells><neurogenic progenitors><neurogenic stem cell><neuron progenitors><neuronal><neuronal progenitor><neuronal progenitor cells><neuronal stem cells><neuroprogenitor><new technology><novel><novel technologies><on a chip><on chip><organ chip><organ on a chip><organ on chip><pathophysiology><pediatric><pediatric patients><pelvirectal achalasia><postnatal><progenitor and neural stem cells><progenitor cell proliferation><progenitor proliferation><quality of life improvement><research and methods><resection><response><shear stress><skills><social role><stem and progenitor cell proliferation><stem cell proliferation><stressor><synergism><three dimensional><translational impact><youngster><µfluidic><µfluidic technology>
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Sarah A Stotz

COLORADO STATE UNIVERSITY, FORT COLLINS, CO

Exploratory lead · 30/100
Very recent
Active award
$119,536
FY 2026

Project Title

Assessment of the contextual factors that influence implementation of a type 2 diabetes nutrition education curriculum in American Indian and Alaska Native-serving healthcare and community-based org

Grant Number:

1R03DK147765-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/6/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY / ABSTRACT American Indian and Alaska Native (AI/AN) adults experience disproportionately high rates of type 2 diabetes (T2D) and face significant barriers to effective diabetes management. Group-based nutrition education has proven effective for improving nutrition self-efficacy, di...

Research Terms

<21+ years old><Address><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Alaska Indian><Alaska Native><Alaska Native group><Alaska Native individual><Alaska Native people><Alaska Native population><Alaska Natives><Alaskan American><Alaskan Indian><Alaskan Native><Alaskan Native American><Alaskan Natives><American><American Indian><American Indian Population><American Indian group><American Indian individual><American Indian people><American Indians><Application Context><Awareness><Behavior><Caring><Characteristics><Communities><Community Health><Community Health Aides><Consensus><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Curriculum><Data><Diabetes Mellitus><Diabetic Diet><Dietary intake><Dietitian><Eating><Educational Curriculum><Educational workshop><Effectiveness><Evaluation><Exercise><Face><Feedback><Focus Groups><Food><Food Intake><Future><Glycohemoglobin A><Glycosylated hemoglobin A><Grant><Habits><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Health Benefit><Health Care><Health Food><Healthy Eating><Healthy diet><Hemoglobin A(1)><Individual><Intake><Intervention><Interview><Investigators><K01 Award><K01 Mechanism><K01 Program><Ketosis-Resistant Diabetes Mellitus><Knowledge><Laws><Leadership><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Maps><Maturity-Onset Diabetes Mellitus><Mentored Research Scientist Development Award><Mentored Training Award><Methods><Modeling><Motivation><NIDDK><NIDDM><National Institute of Diabetes and Digestive and Kidney Diseases><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nutrition><Nutritious food><Outcome><Participant><Patients><Persons><Policies><Population><Process><Public Health><Randomized, Controlled Trials><Recommendation><Reporting><Research><Research Personnel><Research Resources><Research Scientist Development Award><Researchers><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Schedule><Science><Self Efficacy><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Structure><T2 DM><T2D><T2DM><Testing><Time><Trainers Training><Training><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><Update><Work><Workshop><acceptability and feasibility><adult onset diabetes><adulthood><balanced diet><career><community health worker><community-based health><contextual factors><culturally adapted intervention><culturally appropriate intervention><culturally centered intervention><culturally focused intervention><culturally informed intervention><culturally responsive intervention><culturally tailored intervention><diabetes><diabetes education><diabetes management><diabetes mellitus management><diabetes nutrition><diabetes self-care><diabetes self-management><diabetic management><diet education><dietary><education resources><educational resources><effectiveness/implementation hybrid><experience><faces><facial><good diet><health organization><healthy food><hemoglobin A1c><implementation efforts><implementation research><implementation science><implementation strategy><improved><informant><innovate><innovation><innovative><insight><ketosis resistant diabetes><lesson plans><maturity onset diabetes><novel><nutrition education><peer><peer support><pilot test><preservation><programs><randomized control trial><response><self-management program><social cognitive theory><social learning theory><strategies for implementation><tool><translational investigator><translational researcher><translational scientist><trend><type 2 DM><type II DM><type two diabetes>
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Carolyn C. Foster

LURIE CHILDREN'S HOSPITAL OF CHICAGO, CHICAGO, IL

Exploratory lead · 30/100
Very recent
Active award
$117,750
FY 2026

Project Title

Implementation of Remote Patient Monitoring in Pediatric Invasive Home Mechanical Ventilation Using Wireless Devices

Grant Number:

5R03HL176736-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2025

End Date:

12/31/2026

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY/ABSTRACT Children who use invasive home mechanical ventilation (IHMV) are a growing population of pediatric patients with severe bronchopulmonary dysplasia, lung or airway malformations, or neuromuscular conditions affecting respiration who are reliant on positive pressure ventilatio...

Research Terms

<0-11 years old><Address><Adoption><Affect><Age><Appointment><Artificial Respiration><Biosensor><Bronchopulmonary Dysplasia><Burden on their caregivers><CO2><Carbon Dioxide><Carbonic Anhydride><Caregiver Burden><Caring><Cell Communication and Signaling><Cell Signaling><Child><Child Care><Child Youth><Childhood><Children (0-21)><Chronic><Clinic><Clinical><Collaborations><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Data><Data Collection><Dependence><Devices><Diagnostic Findings><Domiciliary Care><Electronic Health Record><Employment><Ensure><Extremities><Family><Family Care Giver><Family Caregiver><Frequencies><Future><Goals><Grant><Hand><Health><Health Care><Health Care Costs><Health Care Systems><Health Costs><Health system><Home><Home Care Services><Hospital Charges><Hour><Intervention><Interview><Intracellular Communication and Signaling><Learning><Life><Limb structure><Limbs><Link><Lung><Lung Respiratory System><Medical Technology><Methods><Multi-Institutional Clinical Trial><Multi-center clinical trial><Multi-site clinical trial><Multicenter clinical trial><Multisite clinical trial><Neuromuscular conditions><Noise><Non-Trunk><Out-patients><Outpatients><Parents><Patients><Pattern><Persons><Physiologic><Physiological><Population><Prevalence><Process><Publishing><Puericulture><Reporting><Research><Respiration><Risk><Sampling><Signal Transduction><Signal Transduction Systems><Signaling><Signs and Symptoms><Sternum><Subgroup><Symptoms><Time><Titrations><Tracheostomy><Tracheostomy procedure><Transportation><Ventilator><Work><ages><biological sensor><biological signal transduction><burden in caregivers><burden of their caregivers><burden on caregivers><care giving><care giving burden><caregiving><caregiving burden><caregiving stress><child health care><child patients><chronic lung disease in infants><chronic lung disease in neonatal infants><chronic lung disease in neonates><chronic lung disease in newborns><chronic lung disease in prematurity><chronic lung disease in preterm infants><chronic lung disease of infancy><chronic lung disease of prematurity><cognitive burden><cognitive load><cost><cost estimate><cost estimation><dashboard><data quality><death risk><design><designing><disparate effect><disparate impact><disparate result><efficacy testing><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><evidence base><experience><family care giving><family caregiving><flexibility><flexible><hands><health and care delivery><health care delivery><health delivery systems><health services delivery><home health care><home mechanical ventilation><homes><implementation framework><implementation research framework><implementation science framework><implementation strategy><improved><inequitable effect><inequitable impact><inequitable outcome><infant chronic lung disease><infants with chronic lung disease><kids><malformation><mortality risk><neonatal chronic lung disease><neuromuscular><newborn chronic lung disease><novel><outcome disparities><outcome inequality><outcome inequity><parent><pediatric><pediatric care><pediatric health care><pediatric patients><portability><post-prematurity respiratory disease><prediction algorithm><pressure><preterm infants with chronic lung disease><recruit><remote health monitoring><remote monitoring><remote patient monitoring><respiratory><respiratory mechanism><strategies for implementation><trend><unequal effect><unequal impact><unequal outcome><uptake><usability><ventilation><wireless><wireless device><wireless electronic><youngster>
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Gustavo R Ares-Sarmiento

WAYNE STATE UNIVERSITY, DETROIT, MI

Exploratory lead · 30/100
Very recent
Active award
$115,500
FY 2026

Project Title

High salt-dependent regulation of the Na+/K+/2Cl- co-transporter (NKCC2) ubiquitination by E3-ubiquitin ligases in Thick Ascending Limb

Grant Number:

5R03DK140261-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/12/2025

End Date:

4/30/2027

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

HYPERTENSION is considered the leading cause of “loss of health” worldwide, involving the kidney’s inability to excrete excess salt. During high salt intake the kidneys excrete the extra salt load by increasing the blood pressure, phenomenon known as the pressure-natriuresis response. On the other h...

Research Terms

<APF-1><ATP-Dependent Proteolysis Factor 1><Acute><African American group><African American individual><African American people><African American population><African Americans><Amino Acid Sequence><Animal Genetics><Animal Model><Animal Models and Related Studies><Ascending Limb of Henle's Loop><BP homeostasis><BP regulation><Biotin><Blood Pressure><Caucasian><Caucasian Race><Caucasians><Caucasoid><Caucasoid Race><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell membrane><Cells><Co-Transporters><Consumption><Coupled><Cyclic GMP><Cytoplasmic Membrane><Data><Defect><Development><Diuretics><Drugs><E3 Ligase><E3 Ubiquitin Ligase><Endogenous Nitrate Vasodilator><Endothelium-Derived Nitric Oxide><Epidemic><Excess Dietary Salt><Excess Salt><Excessive salt consumption><Excretory function><Extremities><F Box><F Box Domain><Gene Deletion><Guanosine Cyclic Monophosphate><HMG-20><Health><High Mobility Protein 20><High dietary salt><Human><Hypertension><Immune Precipitation><Immunoprecipitation><In Vitro><Increased dietary salt><Intracellular Communication and Signaling><Intracellular Second Messenger><KO mice><Kidney><Kidney Urinary System><Knock-out Mice><Knockout Mice><Knowledge><L-Lysine><LC/MS><Leucine><Limb structure><Limbs><Link><Liquid Chromatography><Lysine><Macromolecular Protein Complexes><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Medication><Mice><Mice Mammals><Modern Man><Molecular><Mononitrogen Monoxide><Multiprotein Complexes><Murine><Mus><Natriuresis><Nephrons><Nitric Oxide><Nitrogen Monoxide><Nitrogen Protoxide><Non-Trunk><Normal Range><Normal Values><Null Mouse><Occidental><Patients><Peptides><Pharmaceutical Preparations><Physiology><Plasma Membrane><Plasmids><Play><Polyubiquitination><Population><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Primary Protein Structure><Protein Modification><Proteins><Proteomics><Regulation><Rodent><Rodentia><Rodents Mammals><Role><Second Messenger Systems><Second Messengers><Signal Transduction><Signal Transduction Systems><Signaling><Sodium Chloride><Structure of ascending limb of Henle's loop><System><Thick><Thickness><Time><Transfection><Ubiquitilation><Ubiquitin><Ubiquitin Protein Ligase><Ubiquitin-Protein Ligase Complexes><Ubiquitin-Protein Ligase E3><Ubiquitination><Ubiquitinoylation><Uriniferous Tube><Validation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Vitamin H><absorption><biological signal transduction><blood pressure elevation><blood pressure homeostasis><blood pressure regulation><cGMP><coenzyme R><combat><developmental><drug/agent><elevated blood pressure><elevated dietary salt><elevated salt consumption><endothelial cell derived relaxing factor><excretion><gene deletion mutation><high blood pressure><high salt consumption><high salt diet><high salt intake><high sodium diet><hyperpiesia><hyperpiesis><hypertension treatment><hypertensive><hypertensive disease><hypertensive disorder><in vivo><increase in blood pressure><increased blood pressure><insight><liquid chromatography mass spectrometry><model of animal><natriuretic><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><overconsume dietary salt><plasmalemma><pressure><promoter><promotor><protein sequence><regulate BP><regulate blood pressure><renal><response><salt><salt hypertension><salt induced hypertension><salt intake><salt sensitive hypertension><saluretic><side effect><signal transduction second messengers><social role><symporter><tandem mass spectrometry><ubiquination><ubiquitin conjugation><ubiquitin-protein ligase><validations><white race>
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Jennifer Lynn Warnick

MIRIAM HOSPITAL, PROVIDENCE, RI

Exploratory lead · 30/100
Very recent
Active award
$111,750
FY 2026

Project Title

Comprehensive Assessment and Response for Eating Disorders in Type 1 Diabetes (CARE T1D)

Grant Number:

1R03DK147792-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/5/2026

End Date:

4/30/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT ABSTRACT Nearly one-third of adolescents and young adults (AYAs) with type 1 diabetes (T1D) will develop an eating disorder and approximately 40% will engage in dangerous manipulation of their insulin for weight loss purposes. Left untreated, disordered eating behaviors can lead to significa...

Research Terms

<Address><Adolescent><Adolescent Youth><Adolescent and Young Adult><American><Behavior><Behavior Disorders><Behavior assessment><Body Weight decreased><Brittle Diabetes Mellitus><Caring><Cessation of life><Childhood><Clinic><Competence><Dangerousness><Data><Death><Diabetes Mellitus><Diabetic Acidosis><Diabetic Ketoacidosis><Diabetic Ketosis><Diagnosis><Dissemination and Implementation><E-learning><Early Intervention><Early identification><Eating Behavior><Eating Disorders><Education><Education and Training><Educational aspects><Electronic Health Record><Endocrinology><Feedback><Future><Goals><Grant><Guidelines><Health><Health Care><Health Care Professional><Health Care Providers><Health Personnel><Health Professional><Health behavior><History><Humulin R><IDDM><Insulin><Insulin-Dependent Diabetes Mellitus><International><Intervention><Interview><Juvenile-Onset Diabetes Mellitus><K23 Award><K23 Mechanism><K23 Program><Ketosis-Prone Diabetes Mellitus><Kidney Diseases><Knowledge><Learning><Left><Life Style><Lifestyle><Literature><Measures><Medical><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Metabolism and Endocrinology><Morbidity><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Nephropathy><Neuropathy><Novolin R><Nurse Practitioners><Outcome><Participant><Pathway interactions><Patient Care><Patient Care Delivery><Patients><Pilot Projects><Population><Provider><R-Series Research Projects><R01 Mechanism><R01 Program><Randomized, Controlled Trials><Recommendation><Recording of previous events><Regular Insulin><Relative Risks><Renal Disease><Reporting><Research><Research Design><Research Grants><Research Project Grants><Research Projects><Retinal Diseases><Retinal Disorder><Risk><Risk Factors><Screening procedure><Self Efficacy><Series><Shapes><Societies><Study Type><Sudden-Onset Diabetes Mellitus><Symptoms><T1 DM><T1 diabetes><T1D><T1DM><Testing><Training><Training Programs><Training and Education><Trust><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Weight><Weight Loss><Weight Reduction><Work><Youth><Youth 10-21><acceptability and feasibility><arm><behavior change><behavioral assessment><behavioral disorder><biopsychosocial><body weight loss><care for patients><care of patients><caring for patients><child health care provider><clinical care><clinical practice><co-morbid><co-morbidity><cohort><comorbidity><computer-assisted instruction><computer-based education><computer-based instruction><computer-based learning><computer-based training><death risk><diabetes><diabetic ketoacidotic><digital education><digital learning><eLearning><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic learning><electronic medical health record><evidence base><health care personnel><health care worker><health provider><health related behavior><health staff><health workers><health workforce><healthcare employees><healthcare staff><healthcare workforce><histories><improved><information gathering><insulin dependent diabetes><insulin dependent type 1><internet-assisted education><internet-based training><juvenile><juvenile diabetes><juvenile diabetes mellitus><juvenile human><ketosis prone diabetes><kidney disorder><manage symptom><medical care providers><medical personnel><mortality><mortality risk><multimedia learning><neuropathic><novel><obesity risk><on-line education><on-line learning><online education><online learning><pathway><pediatric><pediatric care provider><pediatric health care provider><pediatric provider><pediatrician><pilot study><programs><provider intervention><randomized control trial><renal disorder><response><retina disease><retina disorder><retinopathy><risk for obesity><risk of obesity><routine care><screening><screening tools><screenings><skill acquisition><skill development><skills><study design><symptom management><technology-enhanced learning><treatment provider><type I diabetes><type one diabetes><virtual learning><web-based instruction><web-based training><weights><wt-loss><youth age>
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Jennifer Lynn Hyde

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 30/100
Very recent
Active award
$88,250
FY 2026

Project Title

Development of molecular tools and mouse models to study neglected Sindbis virus genotypes and their epidemic potential

Grant Number:

1R03AI197103-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/16/2026

End Date:

3/31/2028

Why this may be worth a closer look

  • • Award timing is recent enough to matter for outreach and opportunity scanning.

Project Abstract

PROJECT SUMMARY Sindbis virus (SINV) is a mosquito-borne alphavirus with a single-stranded positive-sense RNA genome. SINV is transmitted between mosquitoes and birds which serve as reservoir hosts for the virus but can cause spillover infections in other vertebrate hosts including humans. SINV can ...

Research Terms

<(TNF)-α><21+ years old><Acute><Adult><Adult Human><Africa><Alpha Virus><Americas><Animal Model><Animal Models and Related Studies><Animals><Antibodies><Arboviral><Arboviruses><Area><Arthralgia><Arthritogenic><Arthropod-Borne Viruses><Attention><Australia><Aves><Avian><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Beta Proprotein Interleukin 1><Birds><Body Tissues><CHIKV><CRG-2><CXCL10><CXCL10 gene><Cachectin><Categories><Cell Line><CellLine><Chikungunya virus><Chronic><Classification><Communities><Complementary DNA><Culicidae><Data><Development><Disease><Disease Outbreaks><Disorder><Engineering><Epidemic><Fever><Fibroblasts><Genetic><Genetic Determinism><Genome><Genomics><Genotype><Geography><Group A Arboviruses><HPGF><Hepatic Cells><Hepatic Parenchymal Cell><Hepatocyte><Hepatocyte-Stimulating Factor><Human><Hybridoma Growth Factor><IFI10><IFN><IFN-beta 2><IFNB2><IL-1 beta><IL-1 β><IL-1-b><IL-1β><IL-6><IL1-Beta><IL1-β><IL1B Protein><IL1F2><IL1β><IL6 Protein><INP10><IP-10><Immune response><Immunity><In Vitro><Infection><Inflammatory><Interferons><Interleukin 1beta><Interleukin-1 beta><Interleukin-1β><Interleukin-6><Investigation><Joint Pain><Joints><Kinetics><Liver Cells><MAYV><MGI-2><MOB-1><Macrophage><Macrophage-Derived TNF><Mayaro alphavirus><Mayaro virus><Measures><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Molecular Cloning><Monocyte-Derived TNF><Mosquitoes><Murine><Mus><Myeloid Differentiation-Inducing Protein><Mφ><Nature><Non-Polyadenylated RNA><North Africa><Northern Africa><Northern Europe><Osteoclasts><Outbreaks><Pathogenesis><Pathogenicity><Pathology><Periodicals><Phenotype><Plaque Assay><Plasmacytoma Growth Factor><Polyarthritides><Population><Preinterleukin 1 Beta><Prevalence><Production><Property><Pyrexia><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><RNA><RNA Gene Products><RNA Viruses><RNA chemical synthesis><RNA synthesis><Recurrent disease><Relapsed Disease><Reporting><Research><Ribonucleic Acid><Ross river virus><SCYB10><Serology><Sindbis Virus><Skin><Strains Cell Lines><Systematics><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Tissues><Transmission><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><Viral><Viral Burden><Viral Diseases><Viral Genetics><Viral Load><Viral Load result><Viral Pathogenesis><Virus><Virus Diseases><Virus Replication><adulthood><burden of disease><burden of illness><cDNA><cell type><comparative><cultured cell line><cytokine><developmental><disease burden><epidemic concern><epidemic potential><epidemic risk><epidemic threat><febrile><febris><fitness><gIP-10><genetic determinant><host response><human disease><immune system response><immunoresponse><in vivo><in vivo Model><interferon beta 2><model of animal><mosquito-borne><mosquitoborne><mouse model><murine model><neglect><novel><periodic><periodical><polyarthritis><prototype><qRTPCR><response><subcutaneous><subdermal><therapeutically effective><tool><transmission process><vector competence><vectorial competence><viral RNA><viral infection><viral multiplication><viral replication><virus RNA><virus genetics><virus infection><virus multiplication><virus pathogenesis><virus-induced disease>
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Shannon Farris

VIRGINIA POLYTECHNIC INST AND ST UNIV, BLACKSBURG, VA

Exploratory lead · 26/100
Solid budget
Active award
$322,000
FY 2026

Project Title

Mitochondria and synapse crosstalk in AD circuit vulnerability

Grant Number:

1R03AG093239-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT The rising prevalence of Alzheimer's Disease (AD) poses a significant challenge for human health. Characterized by progressive memory loss and cognitive decline, the long-term care costs for AD patients in the U.S. is expected to reach a trillion dollars by 2050. Despite dec...

Research Terms

<AD brain><AD dementia><AD model><AD pathology><AD patients><Acute><Address><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's pathology><Alzheimer's patient><Alzheimers Dementia><Ammon Horn><Amyloid><Amyloid Substance><Animal Model><Animal Models and Related Studies><Autopsy><Biology><Brain><Brain Nervous System><Calcium><Calcium Ion Signaling><Calcium Signaling><Cell Communication and Signaling><Cell Signaling><Clinical Research><Clinical Study><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Data><Dendrites><Dentate Fascia><Disease><Disease Progression><Disorder><Distal><Disturbance in cognition><Dysfunction><Encephalon><Entorhinal Area><Exhibits><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fascia Dentata><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Functional disorder><Funding><Gyrus Dentatus><Health><Heterogeneity><Hippocampus><Human><Impaired cognition><Impairment><Intracellular Communication and Signaling><Knowledge><Long-Term Care><MT-bound tau><Mediating><Memory><Memory Deficit><Memory Loss><Memory impairment><Mice><Mice Mammals><Mitochondria><Mitochondrial Proteins><Modeling><Modern Man><Molecular><Morphology><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuron Degeneration><Neurons><Outcome><Output><Pathologic><Pathology><Physiology><Physiopathology><Pilot Projects><Population><Predisposition><Prevalence><Primary Senile Degenerative Dementia><Reporting><Research><Role><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Site><Slice><Susceptibility><Synapses><Synaptic><Synaptic Receptors><Tauopathies><Testing><Transcript><alzheimer model><amyloid pathology><biological signal transduction><calcium uniporter><care costs><cognitive dysfunction><cognitive loss><dentate gyrus><entorhinal cortex><excitatory neuron><extended care><hippocampal><memory decline><memory dysfunction><microtubule bound tau><microtubule-bound tau><mitochondrial><mitochondrial dysfunction><model of animal><mouse model><murine model><necropsy><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal><neuronal degeneration><neuropathologic tau><neuropathological tau><next generation><pathophysiology><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><pilot study><postmortem><postsynaptic><prevent><preventing><primary degenerative dementia><programs><senile dementia of the Alzheimer type><social><social role><synapse><synapse function><synaptic function><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic target><uptake><τ Proteins>
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Sharon Ann Swanger

VIRGINIA POLYTECHNIC INST AND ST UNIV, BLACKSBURG, VA

Exploratory lead · 26/100
Solid budget
Active award
$322,000
FY 2026

Project Title

Mitochondria and synapse crosstalk in AD circuit vulnerability

Grant Number:

1R03AG093239-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT The rising prevalence of Alzheimer's Disease (AD) poses a significant challenge for human health. Characterized by progressive memory loss and cognitive decline, the long-term care costs for AD patients in the U.S. is expected to reach a trillion dollars by 2050. Despite dec...

Research Terms

<AD brain><AD dementia><AD model><AD pathology><AD patients><Acute><Address><Affect><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's brain><Alzheimer's disease brain><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's pathology><Alzheimer's patient><Alzheimers Dementia><Ammon Horn><Amyloid><Amyloid Substance><Animal Model><Animal Models and Related Studies><Autopsy><Biology><Brain><Brain Nervous System><Calcium><Calcium Ion Signaling><Calcium Signaling><Cell Communication and Signaling><Cell Signaling><Clinical Research><Clinical Study><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cornu Ammonis><Data><Dendrites><Dentate Fascia><Disease><Disease Progression><Disorder><Distal><Disturbance in cognition><Dysfunction><Encephalon><Entorhinal Area><Exhibits><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fascia Dentata><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Functional disorder><Funding><Gyrus Dentatus><Health><Heterogeneity><Hippocampus><Human><Impaired cognition><Impairment><Intracellular Communication and Signaling><Knowledge><Long-Term Care><MT-bound tau><Mediating><Memory><Memory Deficit><Memory Loss><Memory impairment><Mice><Mice Mammals><Mitochondria><Mitochondrial Proteins><Modeling><Modern Man><Molecular><Morphology><Murine><Mus><Nerve Cells><Nerve Degeneration><Nerve Unit><Neural Cell><Neurocyte><Neuron Degeneration><Neurons><Outcome><Output><Pathologic><Pathology><Physiology><Physiopathology><Pilot Projects><Population><Predisposition><Prevalence><Primary Senile Degenerative Dementia><Reporting><Research><Role><Sensory><Signal Transduction><Signal Transduction Systems><Signaling><Site><Slice><Susceptibility><Synapses><Synaptic><Synaptic Receptors><Tauopathies><Testing><Transcript><alzheimer model><amyloid pathology><biological signal transduction><calcium uniporter><care costs><cognitive dysfunction><cognitive loss><dentate gyrus><entorhinal cortex><excitatory neuron><extended care><hippocampal><memory decline><memory dysfunction><microtubule bound tau><microtubule-bound tau><mitochondrial><mitochondrial dysfunction><model of animal><mouse model><murine model><necropsy><neural degeneration><neurodegeneration><neurodegenerative><neurological degeneration><neuronal><neuronal degeneration><neuropathologic tau><neuropathological tau><next generation><pathophysiology><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><patients with AD><pilot study><postmortem><postsynaptic><prevent><preventing><primary degenerative dementia><programs><senile dementia of the Alzheimer type><social><social role><synapse><synapse function><synaptic function><tau><tau Proteins><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau factor><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><therapeutic target><uptake><τ Proteins>
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Seethal Jacob

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Exploratory lead · 26/100
Training-friendly
Career award
$184,137
FY 2025

Project Title

Telemedicine for Pediatric Sickle Cell Care in Medically Underserved Communities

Grant Number:

5K23HL143162-05

Activity Code:

K23

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

5/1/2021

End Date:

4/30/2026

Why this may be worth a closer look

  • • Activity code is useful for trainees, fellows, or mentored roles.

Project Abstract

Sickle cell disease (SCD) is the most common inherited hematologic disease. Studies have shown that comprehensive medical care can decrease adverse outcomes associated with SCD, but such care is not easily accessed. It is estimated that less than 70% of children with SCD receive comprehensive care, ...

Research Terms

<0-11 years old><0-4 weeks old><AHCPR><AHRQ><Address><Adherence><Affect><African American><Afro American><Afroamerican><Agency for Health Care Policy and Research><Agency for Healthcare Research and Quality><Anxiety><Area><Blood Diseases><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><Care Givers><Caregivers><Caring><Child><Child Care><Child Youth><Childhood><Children (0-21)><Chronic><Chronic Disease><Chronic Illness><Clinical><Communities><Comprehensive Health Care><Consultations><Diabetes Mellitus><Disease><Disease Outcome><Disorder><Education><Educational aspects><Environment><Evaluation><Faculty><Family><Funding><Genetic Counseling><Goals><Hb SS disease><HbSS disease><Health><Health Care><Health Care Utilization><Health Services><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematologist><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hereditary><Hospital Admission><Hospitalization><Hydroxycarbamid><Hydroxycarbamide><Improve Access><Increase lifespan><Indiana><Information Technology><Inherited><Investigators><K12><K12 Award><K12 Mechanism><K12 Program><K23 Award><K23 Mechanism><K23 Program><Measures><Medical><Medically Underserved Area><Mentored Clinical Scientist Development Program><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentorship><Modeling><Modernization><Newborn Infant><Newborns><Outcome><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Population><Position><Positioning Attribute><Preparation><Preventative therapy><Preventive therapy><Process><Provider><Psychosocial Assessment and Care><Puericulture><QOC><Quality of Care><Randomized, Controlled Trials><Reporting><Research><Research Methodology><Research Methods><Research Personnel><Research Proposals><Researchers><Rural><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Services><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Sickle Cell><Sickle Cell Anemia><Stress><Telemedicine><Time><Transportation><Travel><United States Agency for Health Care Policy and Research><United States Agency for Healthcare Research and Quality><Wait Time><Work><acceptability and feasibility><adverse consequence><adverse outcome><assess effectiveness><barrier to care><barrier to health care><barrier to treatment><blood disorder><boost longevity><care coordination><career development><chronic disorder><clinical care><comprehensive care><consultation><coordinating care><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><determine effectiveness><diabetes><effectiveness assessment><effectiveness evaluation><elongating the lifespan><enhance longevity><evaluate effectiveness><evidence base><examine effectiveness><experience><extend life span><extend lifespan><extend longevity><foster longevity><genetic consultation><health care service use><health care service utilization><hydroxy-urea><hydroxyurea><implementation science><improve lifespan><improve longevity><improved><kids><lifespan extension><medically under served><medically under served area><medically underserved><metropolitan><multidisciplinary><newborn child><newborn children><obstacle to care><obstacle to health care><pandemic><pandemic disease><patient centered><patient oriented><patient oriented outcomes><pediatric><pilot test><preparations><prolong lifespan><prolong longevity><promote lifespan><promote longevity><psychosocial assessment><psychosocial care><psychosocial studies><psychosocial support><randomized control trial><research and methods><rural area><rural location><rural region><rural under served><rural underserved><satisfaction><scale up><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sickle RBC><sickle cell disease><sickle cell disorder><sickle disease><sickle erythrocyte><sickle red blood cell><sicklemia><skills><support longevity><tertiary care><under served area><under served community><under served geographic area><under served location><under served region><underserved area><underserved community><underserved geographic area><underserved location><underserved region><youngster>
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TERENCE S. DERMODY

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 24/100
Active award
Career award
$237,419
FY 2026

Project Title

Molecular Basis of Pediatric Disease

Grant Number:

5K12HD052892-19

Activity Code:

K12

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/10/2007

End Date:

11/30/2027

Project Abstract

This proposal requests continued Child Health Research Career Development Award (CHRCDA) support for the Molecular Basis of Pediatric Disease Training Program at the University of Pittsburgh and UPMC Children’s Hospital of Pittsburgh (CHP). The primary goal of the Molecular Basis of Pediatric Diseas...

Research Terms

<Award><Biomedical Research><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Child Health><Childhood><Children's Hospital><Dedications><Department chair><Disease><Disorder><Environment><Faculty><Fostering><Funding><Future><Goals><Grant><Individual><Investigators><K-Awards><K-Series Research Career Programs><Laboratories><Mentors><Molecular><NIH><National Institutes of Health><Outcome><Pediatric Hospitals><Pediatric Research><Physicians><Publications><R-Series Research Projects><R01 Mechanism><R01 Program><Reproducibility><Request for Proposals><Research><Research Career Program><Research Grants><Research Personnel><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Scholars Program><Scientific Inquiry><Scientific Publication><Scientist><Secure><Talents><Training><Training Programs><United States National Institutes of Health><Universities><Writing><career><design><designing><experience><faculty mentor><full professor><high standard><improved><innovate><innovation><innovative><pediatric><pediatric department><peer coaching><peer instruction><peer led team learning><peer mentoring><peer teaching><programs><senior faculty><sq. ft><square foot><training opportunity>
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Ursula Martinez Pradeda

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 24/100
Active award
Career award
$194,265
FY 2026

Project Title

Enhancing motivation to quit smoking via self-help intervention targeted to cancer type: A pilot RCT

Grant Number:

5K22CA276255-03

Activity Code:

K22

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

2/7/2024

End Date:

1/31/2027

Project Abstract

Project Summary/Abstract Tobacco smoking is causally related to at least 12 cancer types. Quitting smoking after cancer is critical for improved treatment outcomes; however, over two-thirds of smokers continue to smoke after a cancer diagnosis. Smoking after cancer increases the risk of mortality an...

Research Terms

<AML - Acute Myeloid Leukemia><Abstinence><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Adherence><Application Context><Attention><Bladder><Bladder Urinary System><Booklets><Breast><Brochures><Cancer Cause><Cancer Etiology><Cancer Patient><Cancer Treatment><Cancers><Cardiovascular Diseases><Caring><Causality><Cervix><Cervix Uteri><Cessation of life><Chest><Clinic><Colon><Colon or Rectum><Colorectal><Confidence Intervals><Counseling><Data><Data Analyses><Data Analysis><Death><Development><Diagnosis><Drugs><Effectiveness of Interventions><Enrollment><Esophageal Cancer><Esophagus Cancer><Etiology><Funding><Future><Gastric Body Cancer><Gastric Cancer><Gastric Cardia Cancer><Gastric Fundus Cancer><Gastric Pylorus Cancer><Goals><Gynecologic><Head and Neck><Head and Neck Cancer><Head and Neck Carcinoma><Head and neck structure><Health><Hepatic Cancer><Hybrids><Individual><Intervention><Investigators><Kidney Cancer><Kidney Carcinoma><Laryngeal Cancer><Link><Lung><Lung Respiratory System><Malignant Esophageal Neoplasm><Malignant Esophageal Tumor><Malignant Gastric Neoplasm><Malignant Gastric Tumor><Malignant Head and Neck Neoplasm><Malignant Laryngeal Tumor><Malignant Melanoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Pancreatic Neoplasm><Malignant Trachea Neoplasm><Malignant Tracheal Neoplasm><Malignant Tracheal Tumor><Malignant Tumor><Malignant Tumor of the Esophagus><Malignant Tumor of the Lung><Malignant Tumor of the Trachea><Malignant Ureter Tumor><Malignant Ureteral Neoplasm><Malignant Ureteral Tumor><Malignant neoplasm of esophagus><Malignant neoplasm of larynx><Malignant neoplasm of liver><Malignant neoplasm of lung><Malignant neoplasm of pancreas><Malignant neoplasm of ureter><Medication><Melanoma><Methods><Modality><Motivation><Nurses><Oncology><Oncology Cancer><Pamphlets><Pancreas Cancer><Pancreatic Cancer><Participant><Patients><Pattern><Pharmaceutical Preparations><Physicians><Population><Primary Neoplasm><Primary Tumor><Procedures><Prognosis><Provider><Pulmonary Cancer><Pulmonary malignant Neoplasm><QOL><Quality of life><Randomized><Randomized, Controlled Trials><Recommendation><Rectum><Recurrent Malignant Neoplasm><Recurrent Malignant Tumor><Renal Cancer><Renal Carcinoma><Reporting><Research><Research Design><Research Personnel><Research Resources><Researchers><Resources><Risk><Risk Factors><Role><Services><Smoke><Smoker><Smoking><Smoking Cessation Intervention><Smoking treatment><Source><Specialist><Stomach Cancer><Study Type><System><Technology><Testing><Thorace><Thoracic><Thorax><Time><Tobacco><Tobacco Consumption><Tobacco smoking><Tobacco smoking behavior><Tobacco use><Trachea Cancer><Training><Treatment Efficacy><Treatment outcome><United States><Ureter Cancer><Ureteral Cancer><Uterine Cervix><acute granulocytic leukemia><acute myeloid leukemia><anti-cancer therapy><brief advice><cancer care><cancer diagnosis><cancer location><cancer recurrence><cancer risk><cancer site><cancer therapy><cancer type><cancer-directed therapy><cardiovascular disorder><care as usual><career><causation><cease smoking><cigarette smoking><cigarette use><colorectum><complex data><contextual factors><coping mechanism><data interpretation><death risk><design><designing><develop therapy><developmental><disease causation><drug/agent><efficacy testing><enroll><evidence base><facilitators to implementation><formative assessment><formative evaluation><future implementation><gastric malignancy><head/neck cancer><implementation facilitators><implementation intervention><implementation science><implementation strategy><improved><intervention delivery><intervention development><intervention effect><intervention efficacy><liver cancer><liver malignancy><lung cancer><malignancy><malignant head and neck tumor><malignant liver tumor><malignant stomach neoplasm><malignant stomach tumor><mortality risk><neoplasm/cancer><non-smoking><nonsmoking><nurse><oesophageal cancer><organizational readiness><pancreatic malignancy><participant engagement><patient engagement><pilot test><programs><quit smoking><randomisation><randomization><randomized control trial><randomly assigned><recruit><routine care><self help><smoking abstinence><smoking cessation><smoking cessation treatment><smoking therapy><social role><stomach fundus cancer><stomach pylorus cancer><stop smoking><strategies for implementation><study design><therapeutic efficacy><therapy development><therapy efficacy><tobacco product use><tracheal cancer><treatment as usual><treatment development><treatment services><urinary bladder><usual care>
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Lieselot Leen Georges Carrette

UNIVERSITY OF CALIFORNIA, SAN DIEGO, LA JOLLA, CA

Exploratory lead · 22/100
Recent
Active award
$239,125
FY 2026

Project Title

Longitudinal Multiparametric Magnetic Resonance Imaging of Outbred Rats with Variable Vulnerability to the Development of Oxycodone Addiction-like Behaviors

Grant Number:

1R03DA064666-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2026

End Date:

2/28/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Advancements in neuroscience, including magnetic resonance imaging (MRI), have significantly improved our understanding of opioid use disorder (OUD) and brain function, yet due to the heterogeneity in the disorder and complexity of the brain, controlled comprehensive approach...

Research Terms

<AMAC-1><AMAC1><Abstinence><Acute><Address><Age><Anatomic Sites><Anatomic structures><Anatomy><Animals><Behavior><Behavioral><Berry><Brain><Brain Diseases><Brain Disorders><Brain Nervous System><Brain imaging><CCL18><CCL18 gene><CKb7><Causality><Cell Body><Cells><Chronic><Classification><Common Rat Strains><Complement><Complement Proteins><Complex><DC-CK1><DCCK1><DWI (diffusion weighted imaging)><DWI-MRI><Data><Data Set><Development><Differences between sexes><Differs between sexes><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Dihydrohydroxycodeinone><Disease><Disorder><Emotional><Encephalon><Encephalon Diseases><Environment><Etiology><Exhibits><Exposure to><Female><Follow-Up Studies><Functional MRI><Functional Magnetic Resonance Imaging><Funding><GWA study><GWAS><Generations><Genetic><Genetic Heterogeneity><Genome><Genomics><Genotype><Goals><Heterogeneity><Human><Image><Individual><Individual Differences><Intake><Intracranial CNS Disorders><Intracranial Central Nervous System Disorders><Intravenous><Investigation><MIP-4><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measurement><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mentorship><Microscopic><Modeling><Modern Man><NIDA><NMR Imaging><NMR Tomography><National Institute of Drug Abuse><National Institute on Drug Abuse><Nature><Neurosciences><Nuclear Magnetic Resonance Imaging><Opiates><Opioid><Oxycodeinon><Oxycodone><Oxycodone SR><Oxycontin><PARC><Pain><Painful><Pharmaceutical Agent><Pharmaceuticals><Pharmacologic Substance><Pharmacological Substance><Phenotype><Population><Population Heterogeneity><Predisposition><Prevention><Protocol><Protocols documentation><Public Health><Rat><Rats Mammals><Rattus><Relapse><Research><Research Resources><Resources><Rewards><Rodent><Rodent Model><Rodentia><Rodents Mammals><Roxicodone><SCYA18><Sample Size><Scientist><Self Administered><Self Administration><Severities><Sex Differences><Sexual differences><Source><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Standardization><Structure><Susceptibility><Systematics><Translating><Translations><Vulnerable Populations><Withdrawal><Work><Zeugmatography><addiction><addictive disorder><ages><biobank><biorepository><brain visualization><causation><clinical relevance><clinically relevant><complementation><dMRI><developmental><diffusion tensor imaging><disability><disease causation><diverse populations><drug metabolism><executive control><executive function><fMRI><follow-up research study><follow-up survey><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><heterogeneous population><human model><imaging><imaging study><improved><incentive salience><individual heterogeneity><individual variability><individual variation><individualized strategies><insight><longitudinal imaging><model of human><neural adaptation><neuroadaptation><opiate consumption><opiate drug use><opiate intake><opiate use><opiate use disorder><opioid consumption><opioid drug use><opioid intake><opioid use><opioid use disorder><oxycodone self-administration><personalization of treatment><personalized medicine><personalized strategies><personalized therapy><personalized treatment><pharmaceutical><population diversity><pre-clinical><pre-clinical imaging><preclinical><preclinical imaging><prevent><preventing><resilience><resilient><response><self-administer oxycodone><serial imaging><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><study with follow-up><translation><treatment strategy><vulnerable group><vulnerable individual><vulnerable people><whole genome association analysis><whole genome association study><♀>
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Yelba Castellon-Lopez

CEDARS-SINAI MEDICAL CENTER, LOS ANGELES, CA

Exploratory lead · 22/100
Recent
Active award
$125,250
FY 2026

Project Title

Leveraging Technology to Promote Physical Activity in Patients with Prediabetes: Movement over Virtual Reality (MoVR)

Grant Number:

1R03DK145960-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/18/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT Physical inactivity is a significant public health concern contributing to numerous chronic diseases including diabetes. Inactivity contributes to 1 in 10 premature deaths and inadequate levels of physical activity are associated with $117 billion in annual health care costs...

Research Terms

<Adherence><Adoption><Adult-Onset Diabetes Mellitus><Area><Award><Biometrics><Biometry><Biostatistics><Body Weight decreased><Caring><Cessation of life><Chronic Disease><Chronic Illness><Clinic><Clinical><Collaborations><Communities><Community Health Aides><Curriculum><Dancing><Data><Death><Devices><Diabetes Mellitus><Educational Curriculum><Eligibility><Eligibility Determination><Exercise><Feasibility Studies><Fostering><Frequencies><Funding><Future><Guidelines><Health Care Costs><Health Costs><Health Promotion><High-Income Populations><Home><Home environment><Incidence><Intervention><Interview><Ketosis-Resistant Diabetes Mellitus><Life Style><Lifestyle><Link><Literature><Low income><Maturity-Onset Diabetes Mellitus><Measures><Monitor><Movement><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Nutrition><Nutritional><Obesity><Outcome><Outcome Study><Participant><Patients><Physical activity><Pilot Projects><Pre-DM><Prediabetes><Prediabetes syndrome><Prediabetic State><Protocol Screening><Public Health><Randomized, Controlled Trials><Recommendation><Research><Research Resources><Resources><Risk><Role><Salutogenesis><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Strenuous Exercise><T2 DM><T2D><T2DM><Technology><Testing><Time><Training><Transportation><Trust><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Weight Loss><Weight Reduction><Work><acceptability and feasibility><adiposity><adult onset diabetes><arm><assess effectiveness><behavior change><body movement><body weight loss><career fair><career networking><chronic disorder><community advisory board><community advisory committee><community advisory panel><community health worker><community safety><community-centered><community-oriented><corpulence><delivered virtually><design><designing><determine effectiveness><determine efficacy><diabetes><diabetes prevention program><digital health><digital literacy><digital technology><effectiveness assessment><effectiveness evaluation><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><emotional experience><evaluate effectiveness><evaluate efficacy><evidence base><examine effectiveness><examine efficacy><exercise intervention><exercise program><experience><fitness program><head mounted device><head mounted display><health administration><health literacy><high income group><high income individual><high income people><high risk><homes><improved><innovate><innovation><innovative><intense exercise><intervention design><ketosis resistant diabetes><lack of physical activity><lesson plans><life style intervention><lifestyle intervention><maturity onset diabetes><meeting><meetings><neighborhood safety><nutritious><participant engagement><participant interview><patient centered><patient engagement><patient oriented><physical activity intervention><physical inactivity><pilot study><pre-diabetes><pre-diabetic><prediabetic><premature><prematurity><prevent><preventing><primary outcome><professional networking><promoting health><randomized control trial><recruit><remote monitoring><response><retention rate><retention strategy><safety net><skills><social><social role><speed networking><strenuous activity><strenuous physical activity><tech-savviness><technology intervention><technology-based interventions><technology-enabled interventions><technology-focused interventions><therapy design><tool><treatment design><type 2 DM><type II DM><type two diabetes><vigorous exercise><vigorous physical activity><virtual delivery><virtual reality><virtual reality displays><virtual reality goggles><virtual reality headset><virtual reality intervention><virtual reality-based intervention><wearable><wearable device><wearable electronics><wearable system><wearable technology><wearable tool><wearables><weight loss program><weight loss programming><wt-loss>
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Jeong H Yun

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 22/100
Recent
Active award
$120,825
FY 2026

Project Title

Early Immune Signatures of COPD: Linking Inflammation to Disease Progression

Grant Number:

1R03HL183108-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2026

End Date:

12/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT The R03 application builds upon Dr. Yun’s K08-funded study, which investigated how hedgehog interacting protein (HHIP) deficiency contributes to lymphocytic inflammation in chronic obstructive pulmonary disease (COPD). Through that work, we identified unique CD8+T cell popul...

Research Terms

<Active Follow-up><Address><Age><Airway Disease><Airway Resistance><Amino Acid Sequence Determinations><Antigens><Autoimmune><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Award><Blood><Blood Reticuloendothelial System><CD8><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CD8B><CD8B1><CD8B1 gene><COPD><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Senescence><Cell Signaling><Cell secretion><Cells><Cellular Aging><Cellular Secretion><Cellular Senescence><Chronic><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Clinical><Clonality><Data><Data Set><Development><Disease><Disease Progression><Disorder><Ectopic lymphoid organ><Ectopic lymphoid structure><Emphysema><Erinaceidae><Expression Signature><Foundations><Funding><Future><GWA study><GWAS><Gene Expression Profile><Genes><Genetic><Genomics><Hedgehogs><Human><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><Immune><Immune Interferon><Immunes><Inflammation><Inflammatory><Interferon Gamma><Interferon Type II><Intracellular Communication and Signaling><K Cells><Killer Cells><LYT3><Lectin><Link><Long-term cohort><Longitudinal cohort><Lung><Lung Diseases><Lung Parenchyma><Lung Respiratory System><Lung Tissue><Lymphatic cell><Lymphocyte><Lymphocytic><Lymphocytic Infiltrate><Lymphoid><MHC Receptor><Major Histocompatibility Complex Receptor><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Memory><Mice><Mice Mammals><Micro Array Data><Modeling><Modern Man><Murine><Mus><Non-Polyadenylated RNA><Onset of illness><Outcome><PBMC><Participant><Pathogenesis><Pathologic Processes><Pathological Processes><Pathology><Patients><Peptide Sequence Determination><Peripheral Blood Mononuclear Cell><Play><Population><Property><Protein Deficiency><Protein Sequence Determinations><Protein Sequencing><Protein Sequencing Molecular Biology><Proteins><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Emphysema><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNAseq><Receptor Protein><Replicative Senescence><Ribonucleic Acid><Role><Sampling><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Structure of parenchyma of lung><Surface Proteins><T cell infiltration><T cell receptor repertoire sequencing><T cell receptor sequencing><T-Cell Antigen Receptors><T-Cell Receptor><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T-cell receptor repertoire><T8 Cells><T8 Lymphocytes><TCR repertoire><TCR repertoire sequencing><TCR sequencing><TCR-seq><TCRseq><Tertiary lymphoid structure><Testing><Time><Work><active followup><ages><autoimmune condition><autoimmune disorder><autoimmunity disease><biological signal transduction><cease smoking><chronic obstructive pulmonary disorder><cigarette smoke exposure><cohort><cytokine><cytotoxic><deficiency of protein><developmental><disease of the lung><disease onset><disorder of the lung><disorder onset><emphysematous><exposure to cigarette smoke><follow up><follow-up><followed up><followup><gene expression pattern><gene expression signature><gene signatures><genetic signature><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><immunogen><insight><lFN-Gamma><lung disorder><lung function decline><lymph cell><mouse model><murine model><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><prevent><preventing><pulmonary function decline><quit smoking><receptor><replicative aging><response><risk stratification><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell technology><single cell transcriptomic profiling><single-cell RNA sequencing><smoking cessation><social role><stop smoking><stratify risk><tertiary lymphoid organ><therapeutic agent development><therapeutic development><therapeutic target><thymus derived lymphocyte><transcriptional profile><transcriptional signature><transcriptome sequencing><transcriptomic sequencing><transcriptomics><whole genome association analysis><whole genome association study>
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Clare Elizabeth Harrop

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 22/100
Recent
Active award
$79,242
FY 2026

Project Title

Sex Informed Profiles of Eating Behaviors in Autism Across Childhood and Young Adulthood

Grant Number:

5R03MH136593-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY Challenging or restrictive eating behaviors are well-documented in autistic individuals. Restrictive eating behaviors, such as food selectivity, refusal and neophobia occur at a greatly increased rate in autism. Eating disorders, such as anorexia nervosa, avoidant restrictive food in...

Research Terms

<0-11 years old><18 year old><18 years of age><21+ years old><4 year old><4 years of age><7 year old><7 years of age><ASD><Address><Adult><Adult Human><Age><Anorexia><Anorexia Nervosa><Area><Autism><Autism Diagnosis><Autistic Disorder><Behavior><Behavior Disorders><Behavioral><Binge eating disorder><Biological><Care Givers><Caregivers><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Chronology><Clinical><Data><Data Set><Development><Diagnosis><Differences between sexes><Differs between sexes><Early Infantile Autism><Eating><Eating Behavior><Eating Disorders><Exhibits><Female><Female Adolescents><Food><Food Intake><Funding><Goals><Hyperphagia><Individual><Infantile Autism><Kanner's Syndrome><Knowledge><Linear Regressions><Measures><Mental disorders><Mental health disorders><Modeling><NICHD><NIH><NIMH><National Institute of Child Health and Human Development><National Institute of Mental Health><National Institutes of Health><Nutritional><Oral><Outcome><Overeating><Patient Self-Report><Phenotype><Population><Predicting Risk><Psychiatric Disease><Psychiatric Disorder><Questionnaires><Research><Role><SAGA><SPT/ADA/Gcn5 Acetyltransferase><Sample Size><Sampling><Self-Report><Sensory><Sex Behavior><Sex Differences><Sex Disorders><Sex Ratio><Sexual Activity><Sexual Behavior><Sexual Dysfunction><Sexual differences><Texture><Time><United States National Institutes of Health><Variant><Variation><adolescent girl><adult with ASD><adult with autism><adult with autism spectrum disorder><adult youth><adulthood><adults on the autism spectrum><adults on the spectrum><age 18><age 18 years><age 4><age 4 years><age 7><age 7 years><age associated><age correlated><age dependent><age linked><age related><age specific><ages><autism spectral disorder><autism spectrum disorder><autistic><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><avoidant restrictive food intake disorder><behavior study><behavioral disorder><behavioral study><biologic><biological sex><biological sex as a modifier><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical significance><clinically significant><cohort><developmental><early childhood><eighteen year old><eighteen years of age><forecasting risk><four year old><four years of age><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><kids><life span><lifespan><male><mental illness><novel><nutritious><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><polyphagia><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><prospective test><psychiatric illness><psychological disorder><repetitive behavior><restrictive eating><risk prediction><risk predictions><seven year old><seven years of age><sex><sex activity><sex as a biological factor><sex as a biological measure><sex as a biological risk factor><sex as a biological variable><sex as a biological variance><sex as a biologically significant variable><sex as a fundamental variable><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><sexual activities><social><social role><trend><young adult><young adult age><young adulthood><youngster><♀><♂>
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GREGORY L WALLACE

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 22/100
Recent
Active award
$79,242
FY 2026

Project Title

Sex Informed Profiles of Eating Behaviors in Autism Across Childhood and Young Adulthood

Grant Number:

5R03MH136593-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY Challenging or restrictive eating behaviors are well-documented in autistic individuals. Restrictive eating behaviors, such as food selectivity, refusal and neophobia occur at a greatly increased rate in autism. Eating disorders, such as anorexia nervosa, avoidant restrictive food in...

Research Terms

<0-11 years old><18 year old><18 years of age><21+ years old><4 year old><4 years of age><7 year old><7 years of age><ASD><Address><Adult><Adult Human><Age><Anorexia><Anorexia Nervosa><Area><Autism><Autism Diagnosis><Autistic Disorder><Behavior><Behavior Disorders><Behavioral><Binge eating disorder><Biological><Care Givers><Caregivers><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Chronology><Clinical><Data><Data Set><Development><Diagnosis><Differences between sexes><Differs between sexes><Early Infantile Autism><Eating><Eating Behavior><Eating Disorders><Exhibits><Female><Female Adolescents><Food><Food Intake><Funding><Goals><Hyperphagia><Individual><Infantile Autism><Kanner's Syndrome><Knowledge><Linear Regressions><Measures><Mental disorders><Mental health disorders><Modeling><NICHD><NIH><NIMH><National Institute of Child Health and Human Development><National Institute of Mental Health><National Institutes of Health><Nutritional><Oral><Outcome><Overeating><Patient Self-Report><Phenotype><Population><Predicting Risk><Psychiatric Disease><Psychiatric Disorder><Questionnaires><Research><Role><SAGA><SPT/ADA/Gcn5 Acetyltransferase><Sample Size><Sampling><Self-Report><Sensory><Sex Behavior><Sex Differences><Sex Disorders><Sex Ratio><Sexual Activity><Sexual Behavior><Sexual Dysfunction><Sexual differences><Texture><Time><United States National Institutes of Health><Variant><Variation><adolescent girl><adult with ASD><adult with autism><adult with autism spectrum disorder><adult youth><adulthood><adults on the autism spectrum><adults on the spectrum><age 18><age 18 years><age 4><age 4 years><age 7><age 7 years><age associated><age correlated><age dependent><age linked><age related><age specific><ages><autism spectral disorder><autism spectrum disorder><autistic><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><avoidant restrictive food intake disorder><behavior study><behavioral disorder><behavioral study><biologic><biological sex><biological sex as a modifier><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><clinical significance><clinically significant><cohort><developmental><early childhood><eighteen year old><eighteen years of age><forecasting risk><four year old><four years of age><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><kids><life span><lifespan><male><mental illness><novel><nutritious><pediatric><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><polyphagia><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive risk><predicts risk><prospective test><psychiatric illness><psychological disorder><repetitive behavior><restrictive eating><risk prediction><risk predictions><seven year old><seven years of age><sex><sex activity><sex as a biological factor><sex as a biological measure><sex as a biological risk factor><sex as a biological variable><sex as a biological variance><sex as a biologically significant variable><sex as a fundamental variable><sex based differences><sex-dependent differences><sex-related differences><sex-specific differences><sexual activities><social><social role><trend><young adult><young adult age><young adulthood><youngster><♀><♂>
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PRASHANT J DESAI

JOHNS HOPKINS UNIVERSITY, BALTIMORE, MD

Exploratory lead · 22/100
Recent
Active award
$77,667
FY 2026

Project Title

Functions of the largest HSV-1 virion protein, pUL36

Grant Number:

5R03AI190227-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Project Abstract

Herpesviruses are major human pathogens that cause life-long persistent infections and result in clinical manifestations that range from a mild cold sore to cancer. Herpes simplex virus (HSV) is among the most frequently encountered pathogen by the general population. Infection with HSV-1 often resu...

Research Terms

<Biological><Blindness><Brain Inflammation><Cancers><Capsid><Cell Body><Cell Nucleus><Cell membrane><Cells><Clinical><Cold Sore><Collection><Cytoplasm><Cytoplasmic Membrane><DNA><DNA Packaging><DNA Replication><DNA Synthesis><DNA biosynthesis><DNA mutation><Data><Deoxyribonucleic Acid><Disease><Disorder><Drugs><Electrons><Encephalitis><Enzyme Gene><Enzymes><Eye diseases><Fever Blister><Gene Transcription><General Population><General Public><Genes><Genetic><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Genital Organs><Genitalia><Genome><Genomic DNA><Glycoproteins><Goals><Grant><HSV><HSV-1><HSV1><Herpes Labialis><Herpes Simplex Type 1><Herpes Simplex Virus><Herpes Simplex Virus 1><Herpes Simplex Virus Type 1><Herpes labialis Virus><Herpesviridae><Herpesvirus 1><Herpesviruses><Herpetic Stomatitis><Image><Infection><Keratitis><Labial Herpes Simplex><Life Cycle><Life Cycle Stages><Long-term infection><Malignant Neoplasms><Malignant Tumor><Maps><Medication><Membrane><Methods><Molecular Genetics><Morphogenesis><Movement><Mutation><Negative Beta Particle><Negatrons><Nuclear><Nucleus><Oral Herpes Simplex><Outcome><Peptide Domain><Pharmaceutical Preparations><Phenotype><Plasma Membrane><Process><Protein Domains><Proteins><RNA Expression><Role><Simplexvirus><Site><Tertiary Protein Structure><Transcription><Vaccines><Viral><Viral Gene Products><Viral Gene Proteins><Viral Genome><Viral Proteins><Virion><Virus><Virus Particle><Virus Replication><biologic><body movement><chronic infection><domain mapping><drug/agent><experience><experiment><experimental research><experimental study><experiments><eye disorder><gDNA><gene null><gene product><genetic selection><genome mutation><herpes febrilis><herpes simplex i><herpes simplex-1><herpes virus><human pathogen><imaging><infected neonate><infected newborn><inhibitor><intraoral herpes simplex infection><intraoral hsv infection><life course><malignancy><membrane structure><morphogenetic process><mutant><neonatal infection><neoplasm/cancer><newborn infection><null mutation><ocular disease><ocular disorder><ophthalmopathy><oral HSV><oral herpes><oral mucosal herpes><particle><pathogen><persistent infection><plasmalemma><polypeptide><prevent><preventing><protein function><social role><viral DNA><viral multiplication><viral replication><virus DNA><virus genome><virus multiplication><virus protein><vision loss><visual loss>
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JEREMY L. GILBERT

CLEMSON UNIVERSITY, CLEMSON, SC

Exploratory lead · 22/100
Recent
Active award
$76,250
FY 2026

Project Title

Tin-Silver Alloy as a Degradable Biomaterial: Biocompatibility Assessment

Grant Number:

5R03EB037137-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2025

End Date:

2/28/2027

Project Abstract

Project Summary/Abstract A component of the Essure® Micro Insert Female Sterilization device is comprised, in part, of a tin-silver (Sn-Ag) solder, a metal alloy which had never been previously implanted into the human body cavity and for which there is little to no peer-reviewed scientific literatu...

Research Terms

<Address><Adolescent><Adolescent Youth><Adverse Experience><Adverse event><Ag element><Alamar Blue><AlamarBlue><Alloys><Animal Model><Animal Models and Related Studies><Animals><Antibodies><Assay><Back><Behavior><Bioassay><Biocompatible Materials><Biological><Biological Assay><Biomaterials><Blood><Blood Plasma><Blood Reticuloendothelial System><Body Tissues><Body cavities><Bone Sarcoma><Calcified><Capsules><Cell Body><Cell Culture Techniques><Cell Differentiation><Cell Differentiation process><Cell Nucleus><Cell Survival><Cell Viability><Cells><Characteristics><Chlorides><Chromium><Collagen><Collagen Type I><Common Rat Strains><Contraceptive Agents><Contraceptives><Corrosion><Coupled><Cr element><Device Approval><Device Approval Process><Device Failures><Device Removal><Devices><Diameter><Dorsum><Electrons><Equipment Malfunction><Exposure to><Fallopian Tubes><Fe element><Female Sterilization><Fiber><Food and Drug Administration><Formaldehyde><Formic Aldehyde><Generalized Growth><Granuloma><Granulomatous Lesion><Growth><H and E><Health Care><Hematoxylin and Eosin><Hematoxylin and Eosin Staining Method><Human><Human Figure><Human body><Immune reaction><Implant><In Vitro><Incubated><Individual><Inflammation><Investigation><Ions><Ir element><Iridium><Iron><Knowledge><Laboratories><Ligaments><Literature><Magnesium><Mammalian Oviducts><Marketing><Medical><Medical Device><Memory><Metals><Methyl Aldehyde><Mg element><Mice><Mice Mammals><Microscope><Microscopy><Mo element><Modeling><Modern Man><Molybdenum><Monitor><Murine><Mus><Negative Beta Particle><Negatrons><Ni element><Nickel><Nucleus><Optics><Orthopedic><Orthopedic Surgical Profession><Orthopedics><Osseous Sarcoma><Osteoblasts><Osteogenic Sarcoma><Osteosarcoma><Oxides><Oxomethane><Patients><Peer Review><Phosphates><Plasma><Plasma Serum><Platinum><Platinum Black><Porosity><Process><Proliferating><Pt element><Publishing><Rat><Rats Mammals><Rattus><Reaction><Reader><Reporting><Research><Reticuloendothelial System, Serum, Plasma><Retrieval><Salpinx><Scanning Electron Microscopy><Severities><Shapes><Silver><Sirius Red F3B><Skeletal Sarcoma><Sn element><SnCl4><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Staining method><Stainless Steel><Stains><Stannum><Surface><Techniques><Tendon structure><Tendons><Thick><Thickness><Ti element><Time><Tin><Tissue Growth><Tissues><Titanium><Translations><Tubal Ligation><Type 1 Collagen><USFDA><United States Food and Drug Administration><Uterine Tubes><Welding><Withdrawal><Woman><Work><biocompatibility><biologic><biological material><biomaterial compatibility><body cavity><calcification><capsule><cell behavior><cell culture><cell cultures><cell type><cellular behavior><cellular differentiation><clinical applicability><clinical application><dacron><digital><experience><fallopian tube ligation><immunoreaction><implantation><in vivo><inorganic phosphate><insight><juvenile><juvenile human><mass spectrometer><metallicity><microscope imaging><microscopic imaging><microscopy imaging><model of animal><novel><ontogeny><optical><osteochondrosarcoma><osteoid sarcoma><oviduct><picrosirius red><post-market><real world application><reconstruction><response><sex><sirius red F 3B><stannic chloride><subcutaneous><subdermal><surveillance study><tin tetrachloride><translation>
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Elizabeth Goldberg

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 20/100
Solid budget
Active award
$429,000
FY 2025

Project Title

e-GAPcare: Expanding the Reach of a Fall Prevention Intervention for Older Adult Emergency Department Patients through Telehealth

Grant Number:

1R21AG091218-01

Activity Code:

R21

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY From Dr. Goldberg’s (principal investigator’s) NIA GEMSSTAR R03 and BEESON K76 research, there is promising evidence that we can prevent fall-related emergency department (ED) visits among older adults with the Geriatric Acute and Post-Acute Fall Prevention (GAPcare) intervention. T...

Research Terms

<Academic Medical Centers><Accident and Emergency department><Acute><Address><Administrator><Age><Aging><Agreement><American><Apoplexy><Brain Vascular Accident><Care Givers><Caregivers><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Clinical><Communities><Computer software><Consult><Consultations><Data><Development><Devices><Drugs><ED care><ED patient><ED visit><ER care><ER patient><ER visit><Elderly><Electronic Health Record><Emergency Care><Emergency Department><Emergency Department care><Emergency Department patient><Emergency Room care><Emergency Room patient><Emergency care visit><Emergency department visit><Emergency health care><Emergency hospital visit><Emergency medical care><Emergency room><Emergency room visit><Equilibrium><Evaluation><Expenditure><Fall prevention><Feasibility Studies><Feedback><Funding><Future><Gait><Goals><Health><Health Care Visit><Health Status><Home><Institution><Interest Group><Intervention><Interview><Length of Stay><Level of Health><Measures><Medication><Methodology><Modeling><Neurologist><Number of Days in Hospital><Nurses><Outcome><Outcome Measure><Participant><Patients><Peer Review><Persons><Pharmaceutical Preparations><Pharmacies><Pharmacists><Pharmacy facility><Phone><Population><Preventative intervention><Prevention><Prevention Protocols><Principal Investigator><Procedures><Protocol><Protocols documentation><QOL><Quality of life><Randomized><Randomized, Controlled Trials><Recommendation><Recurrence><Recurrent><Research><Research Resources><Resources><Review Literature><Risk Assessment><Risk Factors><Rural><Rural Community><Sampling><Services><Site><Software><Specialist><Strategic Planning><Stroke><Structure><Suggestion><Technology><Telephone><Testing><Training><Underrepresented Groups><Underrepresented Populations><University Medical Centers><Urban Community><advanced age><age associated disease><age associated disorder><age associated impairment><age dependent disease><age dependent disorder><age dependent impairment><age related human disease><age-related disease><age-related disorder><age-related impairment><ages><arm><balance><balance function><brain attack><care seeking><cerebral vascular accident><cerebrovascular accident><consultation><consults><determine efficacy><developmental><drug/agent><effective intervention><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><evaluate efficacy><examine efficacy><experience><fall risk><falls><geriatric><health level><homes><hospital days><hospital length of stay><hospital stay><improved><insight><intervention for prevention><measurable outcome><nurse><older adult><older adulthood><outcome measurement><outreach><participant retention><pharmacy benefit><physical therapist><physiotherapist><poor health outcome><practice setting><prevent><preventing><preventing falls><prevention intervention><preventional intervention strategy><preventive intervention><primary care clinician><primary outcome><promoter><promotor><randomisation><randomization><randomized control trial><randomly assigned><recruit><reduced health outcome><satisfaction><senior citizen><stroked><strokes><suburb><suburban><suburban communities><suburbia><telehealth><under representation of groups><under represented groups><under represented people><under represented populations><underrepresentation of groups><underrepresented people><uptake><virtual><virtual patient><worse health outcome>
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Candida Laura Goodnough

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 20/100
Solid budget
Active award
$385,000
FY 2025

Project Title

Targeting Aging-Related Delays in Cognitive Recovery After Anesthesia by Attenuating Oxidative Stress: Implications for Alzheimer's Disease

Grant Number:

1R03AG095807-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2025

End Date:

7/31/2027

Project Abstract

PROJECT SUMMARY The geriatric population is increasingly at risk for anesthetic complications, with postoperative delirium a common and disruptive outcome. Postoperative delirium impairs cognitive recovery, reduces quality of life, and disproportionately affects older adults and patients with Alzhei...

Research Terms

<21+ years old><AD dementia><AD model><AD pathology><ALDH><APOE e4><APOE-ε4><APOEε4><Active Oxygen><Acute><Address><Adult><Adult Human><Advisory Committees><Affect><Age Years><Aging><Aldehydes><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's disease model><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's disease risk><Alzheimer's pathology><Alzheimer's patient><Alzheimers Dementia><Anesthesia><Anesthesia procedures><Anesthestic Drugs><Anesthetic Agents><Anesthetic Drugs><Anesthetics><Award><Basic Research><Basic Science><Behavior><Biochemical><Biochemistry><Biological Chemistry><Biology><Blood Serum><Cerebrospinal Fluid><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Development Plans><Diprivan><Disease Progression><Disoprofol><Disturbance in cognition><EEG><Elderly><Electroencephalogram><Electroencephalography><Food><Foundations><Gene variant><General Anesthesia><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Geriatrics><Goals><Grant><Grooming><Health><High Prevalence><Hour><Human><IQ Deficit><Impaired cognition><Impairment><Individual><Inherited Predisposition><Inherited Susceptibility><Intermediary Metabolism><Intervention><Investments><KI mice><Knock-in Mouse><Knowledge><Lead><Link><Lipid Peroxidation><Measurement><Measures><Mentors><Mentorship><Metabolic Processes><Metabolism><Mice><Mice Mammals><Mission><Modeling><Modern Man><Molecular><Murine><Mus><National Institute of Aging><National Institute on Aging><Nerve Cells><Nerve Unit><Neural Cell><Neurocognitive><Neurocognitive Deficit><Neurocyte><Neurologic><Neurologic outcome><Neurological><Neurological outcome><Neurons><Outcome><Oxidative Stress><Oxidative Stress Induction><Oxygen Radicals><Pathway interactions><Pb element><Perioperative><Play><Population><Precision therapeutics><Primary Senile Degenerative Dementia><Pro-Oxidants><Propofol><Proteins><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><Reactive Oxygen Species><Recovery><Research><Research Grants><Research Project Grants><Research Projects><Research Proposals><Research Resources><Research Training><Resources><Risk><Rod><Rodent Model><Role><Scientist><Serum><Task Forces><Testing><Time><Training><United States><Variant><Variation><Vulnerable Populations><Wild Type Mouse><Work><adduct><adulthood><advanced age><advisory team><age associated difference><age based difference><age dependent difference><age dependent variation><age difference><age related difference><age related variation><age specific difference><aged><aged brain><aged group><aged groups><aged individual><aged individuals><aged mice><aged mouse><aged people><aged person><aged persons><aged population><aged populations><aging associated><aging brain><aging population><aging process><aging related><aldehyde dehydrogenases><allelic variant><alzheimer model><alzheimer risk><apo E-4><apo E4><apo epsilon4><apoE epsilon 4><apoE-4><apoE4><apolipoprotein E epsilon 4><apolipoprotein E-4><apolipoprotein E4><behavior study><behavioral study><brain tissue><cerebral spinal fluid><cognitive dysfunction><cognitive loss><cognitive recovery><differ by age><difference across age><difference in age><elderly mice><elderly patient><genetic etiology><genetic mechanism of disease><genetic variant><genetic vulnerability><genetically predisposed><genomic variant><geriatric><geriatric medicine><healthspan><healthy life span><heavy metal Pb><heavy metal lead><humanized mice><humanized mouse><improved><innovate><innovation><innovative><inpatient surgery><insight><intelligence quotient deficit><knockin mice><mouse model><murine model><neurocognitive decline><neurocognitive impairment><neurological recovery><neuronal><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><old mice><older adult><older adulthood><older patient><oxidative damage><oxidative injury><pathway><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><pharmacologic><population aging><post-operative delirium><postoperative delirium><precision therapies><precision treatment><preference><prevent><preventing><primary degenerative dementia><senile dementia of the Alzheimer type><senior citizen><small molecule><social role><spinal fluid><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><tool><treatment strategy><variation by age><vulnerable group><vulnerable individual><vulnerable people><wildtype mouse>
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Xueling Wu

BOSTON MEDICAL CENTER, BOSTON, MA

Exploratory lead · 20/100
Solid budget
Active award
$356,630
FY 2025

Project Title

Immune profiling of antibodies and B cells that recognize HIV and substances in people who use substances and live with HIV (PWUSH)

Grant Number:

1R03DA064474-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2027

Project Abstract

SUMMARY In response to NIDA PAS-21-270 AIDS-Science Track Award for Research Transition (R03 Clinical Trial Optional), we propose to investigate how drug abuse may impact antibody response in HIV infection. We have previously shown that chronic Cocaine use increased HIV-associated anti-CD4 autoantib...

Research Terms

<7S Gamma Globulin><AIDS><AIDS Virus><Ab-mediated immunity><Ab-mediated protection><Acquired Immune Deficiency><Acquired Immune Deficiency Syndrome><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome><Acquired Immunodeficiency Syndrome Virus><Actiq><Affinity><Animal Model><Animal Models and Related Studies><Antibodies><Antibody Response><Antibody immunity><Antibody protection><Antibody titer measurement><Antibody-mediated protection><Antigen Targeting><Antigens><Autoantibodies><Award><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><B-cell receptor repertoire sequencing><B-cell receptor sequencing><BCR repertoire sequencing><BCR seq><BCR sequencing><BCRseq><Binding><Blood Plasma><Blood Sample><Blood Serum><Blood specimen><Boston><Brain><Brain Nervous System><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Chronic><Clinical><Clinical Treatment Moab><Clinical Trials><Cocaine><Cohort Studies><Comparative Study><Concurrent Studies><Conjugate Vaccines><Data><Development><Diacetylmorphine><Diamorphine><Disease><Disease Progression><Disorder><Dose><Drug Targeting><Drug abuse><Drugs><Duragesic><ELISA><Encephalon><Enzyme-Linked Immunosorbent Assay><Fentanest><Fentanyl><Fentyl><Frequencies><Future><Goals><HIV><HIV 1 associated neurocognitive disorder><HIV Antigens><HIV Infections><HIV associated neurocognitive deficit><HIV associated neurocognitive impairment><HIV induced neurocognitive deficit><HIV induced neurocognitive impairment><HIV neurocognitive impairment><HIV-1 associated neurocognitive deficit><HIV-1 associated neurocognitive disorder><HIV-1 associated neurocognitive impairment><HIV-Associated Antigens><HIV-associated neurocognitive disorder><HTLV-III Antigens><HTLV-III Infections><HTLV-III-LAV Antigens><HTLV-III-LAV Infections><Haptens><Heroin><History><Hospitals><Hu-mABs><Human><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Antigens><Human T-Lymphotropic Virus Type III Infections><IQ Deficit><IgG><Immune><Immune response><Immunes><Immunize><Immunoglobulin G><Intervention><LAV Antigens><LAV-HTLV-III><Lead><Lymphadenopathy-Associated Antigens><Lymphadenopathy-Associated Virus><Measures><Medical><Medical center><Medication><Memory B Cell><Memory B-Lymphocyte><Mice><Mice Mammals><Modern Man><Molecular Interaction><Monoclonal Antibodies><Murine><Mus><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Neurocognitive Deficit><Neurocognitive Impairment in HIV><Neurocognitive Impairment in HIV-1><Opiates><Opioid><Organ><Outcome><PBMC><Pb element><Peripheral Blood Mononuclear Cell><Persons><Pharmaceutical Preparations><Phentanyl><Physiologic><Physiological><Plasma><Plasma Serum><Play><Population><Proteins><Public Health><Rat Transgene><Recording of previous events><Research><Research Specimen><Reticuloendothelial System, Serum, Plasma><Role><Science><Serum><Sorting><South Carolina><Specificity><Specimen><Staining method><Stains><Stigmatization><Structural Protein><Study Subject><Substance abuse problem><Testing><Therapeutic><Universities><Virus-HIV><Vulnerable Populations><Woman><abuse of drugs><abuse of substances><abused drug><abused drugs><abuses drugs><analog><antibody titering><antibody-mediated immunity><antigen based test><antigen test><antiretroviral therapy><antiretroviral treatment><autoimmune antibody><autoreactive antibody><cell sorting><clinical care><cocaine use><demographics><developmental><drug abused><drug of abuse><drug/agent><drugs abused><drugs of abuse><enzyme linked immunoassay><ethnic minority><heavy metal Pb><heavy metal lead><histories><host response><humAbs><human mAbs><human monoclonal antibodies><human monoclonals><immune system response><immunogen><immunoresponse><improved><intelligence quotient deficit><mAbs><marginalization><meeting><meetings><men><model of animal><monoclonal Abs><neural inflammation><neurocognitive decline><neurocognitive impairment><neuroinflammation><neuroinflammatory><neuron toxicity><neuronal toxicity><neurotoxicity><opiate abuse><opiate drug abuse><opioid abuse><opioid drug abuse><peripheral blood><prophylactic><racial minority><response><self reactive antibody><small molecule><social role><study population><substance abuse><substance use><substance using><therapy adherence><therapy compliance><vulnerable group><vulnerable individual><vulnerable people>
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Christophe G. Lambert

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Exploratory lead · 20/100
Solid budget
Active award
$350,000
FY 2025

Project Title

Illuminating the Druggable Genome Data Coordinating Center - Engagement Plan with the CFDE

Grant Number:

4OT2OD030546-02

Activity Code:

OT2

Mechanism:

Other

Agency:

NIH

Start Date:

9/23/2025

End Date:

3/22/2027

Project Abstract

The Illuminating the Druggable Genome (IDG) consortium has two major goals: First, consolidate disparate protein- and disease-centric data types from multiple sources, integrate and harmonize them, then make them readily available to the public; Second, adapt and scale existing technologies to unvei...

Research Terms

<ATP-protein phosphotransferase><Area><Biological><Chemicals><Clinical><Communities><Complex><DNA mutation><Darkness><Data><Data Bases><Data Coordinating Center><Data Coordination Center><Data Set><Databases><Disease><Disorder><Disparate><Ensure><FAIR data><FAIR guiding principles><FAIR principles><Family><Feedback><Findable, Accessible, Interoperable and Re-usable><Findable, Accessible, Interoperable, and Reusable><Funding><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><GTEx><Gene variant><Generations><Genes><Genetic Change><Genetic defect><Genetic mutation><Genome><Genotype><Genotype-Tissue Expression Project><Goals><Investments><Ion Channel><Ionic Channels><Kinase Family Gene><Knowledge Management Center><Manuals><Membrane Channels><Mutation><Pathology><Pathway interactions><Phenotype><Protein Kinase><Proteins><Proteome><Research Resources><Resources><Risk><Source><Structure><Technology><Update><allelic variant><biologic><data base><data integration><depository><design><designing><differential expression><differentially expressed><gene function><genetic variant><genome mutation><genome resource><genomic data resource><genomic resource><genomic sequencing resource><genomic variant><glycogen synthase a kinase><human disease><hydroxyalkyl protein kinase><improved><knowledgebase><member><multiple data types><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><phosphorylase b kinase kinase><programs><repository><transcriptional differences>
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Jeremy Joseph Yang

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Exploratory lead · 20/100
Solid budget
Active award
$350,000
FY 2025

Project Title

Illuminating the Druggable Genome Data Coordinating Center - Engagement Plan with the CFDE

Grant Number:

4OT2OD030546-02

Activity Code:

OT2

Mechanism:

Other

Agency:

NIH

Start Date:

9/23/2025

End Date:

3/22/2027

Project Abstract

The Illuminating the Druggable Genome (IDG) consortium has two major goals: First, consolidate disparate protein- and disease-centric data types from multiple sources, integrate and harmonize them, then make them readily available to the public; Second, adapt and scale existing technologies to unvei...

Research Terms

<ATP-protein phosphotransferase><Area><Biological><Chemicals><Clinical><Communities><Complex><DNA mutation><Darkness><Data><Data Bases><Data Coordinating Center><Data Coordination Center><Data Set><Databases><Disease><Disorder><Disparate><Ensure><FAIR data><FAIR guiding principles><FAIR principles><Family><Feedback><Findable, Accessible, Interoperable and Re-usable><Findable, Accessible, Interoperable, and Reusable><Funding><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><GTEx><Gene variant><Generations><Genes><Genetic Change><Genetic defect><Genetic mutation><Genome><Genotype><Genotype-Tissue Expression Project><Goals><Investments><Ion Channel><Ionic Channels><Kinase Family Gene><Knowledge Management Center><Manuals><Membrane Channels><Mutation><Pathology><Pathway interactions><Phenotype><Protein Kinase><Proteins><Proteome><Research Resources><Resources><Risk><Source><Structure><Technology><Update><allelic variant><biologic><data base><data integration><depository><design><designing><differential expression><differentially expressed><gene function><genetic variant><genome mutation><genome resource><genomic data resource><genomic resource><genomic sequencing resource><genomic variant><glycogen synthase a kinase><human disease><hydroxyalkyl protein kinase><improved><knowledgebase><member><multiple data types><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><phosphorylase b kinase kinase><programs><repository><transcriptional differences>
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Biao Wang

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 20/100
Solid budget
Active award
$328,000
FY 2025

Project Title

Alzheimer's Disease Organelle Proteome Task (ADOPT)-pilot phase

Grant Number:

1R03AG091095-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY Dysfunctions in organelles such as the mitochondria and lysosomes are increasingly being appreciated to drive various forms of neurodegenerative diseases, such as the Alzheimer's disease and Alzheimer's disease-related dementias (AD/ADRD). However, an integrated organelle proteome co...

Research Terms

<ACTL6B><ACTL6B gene><AD dementia><AD model><AD related dementia><ADRD><Address><Age><Age Months><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease model><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amyloid (Aβ) plaques><Amyloid Plaques><Autoregulation><BAF53B><Binding><Biology><Biomedical Research><Brain><Brain Nervous System><Budgets><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Complex><Computer Models><Computerized Models><Cre-Lox><Cre-LoxP><Cre/LoxP><Data><Degenerative Neurologic Disorders><Disease><Disease Progression><Disorder><Disturbance in cognition><Dysfunction><EOAD><Early Onset Alzheimer Disease><Encephalon><Exhibits><Functional disorder><Funding Opportunities><Future><Genetic><Goals><Homeostasis><Human><Impaired cognition><Knowledge><Lysosomes><Maps><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Measures><Membrane><Mice><Mice Mammals><Mitochondria><Modern Man><Molecular><Molecular Interaction><Murine><Mus><Nature><Nerve Cells><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neuritic Plaques><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neurons><Organelles><Pathogenesis><Phase><Physiological Homeostasis><Physiopathology><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Precipitation><Primary Senile Degenerative Dementia><Protein Modification><Proteins><Proteome><Proteomics><Research><Research Resources><Resolution><Resources><Senile Plaques><Shapes><Surface><System><Transgenes><actin-like 6B><ages><alzheimer model><amyloid beta plaque><amyloid-b plaque><aβ plaques><brain tissue><cell type><cognitive dysfunction><cognitive loss><computational modeling><computational models><computer based models><computerized modeling><cored plaque><data acquisition><data acquisitions><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><diffuse plaque><early onset><early onset AD><early onset Alzheimer's><experiment><experimental research><experimental study><experiments><internet resource><magnetic beads><membrane structure><mitochondrial><mouse model><murine model><mutant><neurodegenerative illness><neuronal><on-line compendium><on-line resource><online compendium><online resource><pathophysiology><precipitations><primary degenerative dementia><protein complex><resolutions><senile dementia of the Alzheimer type><transgene><web resource><web-based resource>
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Huitong Ding

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Exploratory lead · 20/100
Solid budget
Active award
$327,000
FY 2025

Project Title

Exploring heterogeneity of cognitive trajectories of preclinical Alzheimer's disease with digital phenotyping

Grant Number:

1R03AG095992-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/5/2025

End Date:

8/31/2027

Project Abstract

PROJECT SUMMARY The heterogeneous nature of Alzheimer’s disease (AD) manifestation and progression poses a significant challenge to developing effective treatments. As a first step toward personalized medicine for AD, it is crucial to identify clinically relevant subtypes, which will enable the crea...

Research Terms

<AD dementia><Acoustics><Affect><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer risk factor><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's diagnosis><Alzheimer's disease diagnosis><Alzheimer's disease risk><Alzheimers Dementia><Brain Vascular><Categories><Characteristics><Clinical><Clinical Data><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cohort Studies><Communities><Computer Models><Computerized Models><Concurrent Studies><Data><Degenerative Neurologic Disorders><Development><Diagnosis><Disease><Disease Progression><Disorder><Disturbance in cognition><Exhibits><Framingham Heart Study><Future><Generations><Goals><Grant><Health><Health Care><Heterogeneity><Impaired cognition><Individual><Intervention><Lipids><Logistic Regressions><Machine Learning><Maps><Measurement><Measures><Metabolic Marker><Methods><Modeling><NIH><National Institutes of Health><Nature><Nervous System Degenerative Diseases><Neural Degenerative Diseases><Neural degenerative Disorders><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuropsychologic Tests><Neuropsychological Tests><Outcome><Participant><Persons><Predictive Factor><Prevention><Primary Senile Degenerative Dementia><Research><Risk Factors><Subgroup><Tauopathies><Time><United States National Institutes of Health><Voice><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age related alterations><age related changes><age specific alterations><age specific changes><ages><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><alterations with age><alzheimer risk><amyloid pathology><cerebral vascular><cerebro-vascular><cerebrovascular><changes with age><clinical diagnosis><clinical relevance><clinical risk><clinically relevant><cognitive change><cognitive dysfunction><cognitive function><cognitive loss><cognitive performance><computational modeling><computational models><computer based models><computerized modeling><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><developmental><digital><digital data><digital phenotyping><effective therapy><effective treatment><experience><feature selection><improved><innovate><innovation><innovative><insight><life-style factor><lifestyle factors><longitudinal data set><longitudinal dataset><machine based learning><machine learning based model><machine learning based prediction model><machine learning based predictive model><machine learning model><machine learning prediction><machine learning prediction model><multi-modal data><multi-modal datasets><multi-modality><multimodal data><multimodal datasets><multimodality><neurodegenerative illness><neuropathologic tau><neuropathological tau><novel><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><pre-clinical><preclinical><primary degenerative dementia><response><risk stratification><screening><screenings><senile dementia of the Alzheimer type><sex><sound><stratify risk><success><tau associated neurodegeneration><tau associated neurodegenerative process><tau driven neurodegeneration><tau induced degeneration><tau induced neurodegeneration><tau mediated neurodegeneration><tau neurodegenerative disease><tau neuropathology><tau pathology><tau pathophysiology><tau proteinopathy><tau related neurodegeneration><tau-induced pathology><tauopathic neurodegenerative disorder><tauopathy><vascular risk factor>
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Mizuho Kittaka

AUGUSTA UNIVERSITY, AUGUSTA, GA

Exploratory lead · 20/100
Solid budget
Active award
$322,313
FY 2025

Project Title

Osteocytes-bacteria interaction via NOD1 as a mechanism of bone loss in periodontitis

Grant Number:

1R03DE034787-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2025

End Date:

6/14/2027

Project Abstract

Project Summary/Abstract Periodontal disease (PD) is a prevalent disorder affecting nearly half of US adults. Bacterially induced PD is a leading cause of tooth loss. Around 20% of the patients do not respond to current treatment, and PD remains a global health problem. In order to develop novel str...

Research Terms

<21+ years old><A actinomycetemcomitans><A. actinomycetemcomitans><Abscission><Actinobacillus actinomycetemcomitans><Adult><Adult Human><Affect><Aggregatibacter actinomycetemcomitans><Agreement><Alveolar Bone Loss><Alveolar Resorption><Apical Periodontitis><Arthroplasty><Autoregulation><Bacteria><Bacterium actinomycetem comitans><Bacterium comitans><Bacteroides gingivalis><Binding><Biology><Body Tissues><Bone Formation><Bone Infection><Bone Matrix><Bone Resorption><C fusiforme><C. fusiforme><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><CellLine><Cells><Characteristics><Chronic Periodontitis><Corynebacterium fusiforme><Data><Dependence><Detection><Disease><Disorder><ELISA><Enzyme-Linked Immunosorbent Assay><Excision><Extirpation><Extracellular Signal-Regulated Kinase Gene><F fusiformis><F nucleatum><F nucleatus><F. fusiformis><F. nucleatum><F. nucleatus><FBJ osteosarcoma oncogene><FOS gene><Foundations><Fusiformis fusiformis><Fusiformis nucleatus><Fusobacterium nucleatum><Future><G0S7><Gene Expression><Gene Transcription><Genetic><Genetic Transcription><Gram-Negative Bacteria><Gum Disease><Homeostasis><Human><Immune response><Immunoblotting><In Vitro><Infection><Inflammation><Inflammatory Response><Intracellular Communication and Signaling><Joint Prosthesis Implantation><Knowledge><Lead><Ligature><MAP Kinase Gene><MAPK><Mechanics><Mice><Mice Mammals><Microbiology><Mitogen-Activated Protein Kinase Gene><Modeling><Modern Man><Molecular><Molecular Interaction><Murein><Murine><Mus><Nucleotides><OPGL><Osteoblasts><Osteoclastic Bone Loss><Osteoclasts><Osteocytes><Osteogenesis><Osteomyelitis><Outcome><P gingivalis><P. gingivalis><Parodontosis><Patients><Pattern recognition receptor><Pb element><Peptidoglycan><Periapical Periodontitis><Periodontal Bone Loss><Periodontal Diseases><Periodontal Resorption><Periodontitis><Physiological Homeostasis><Play><Porphyromonas gingivalis><Production><Protooncogene FOS><Public Health><RANKL><RNA Expression><Removal><Replacement Arthroplasty><Role><Signal Transduction><Signal Transduction Systems><Signaling><Source><Strains Cell Lines><Surgical Removal><TNFSF11><TNFSF11 gene><Testing><Therapeutic><Tissues><Tooth><Tooth Loss><Tooth structure><Transcription><Western Blotting><Western Immunoblotting><adulthood><alternative treatment><alveolar bone><alveolar supporting bone><bacteria pathogen><bacterial pathogen><biological signal transduction><bone><bone cell><bone loss><bone tissue formation><c fos><c-fos Gene><c-fos Proto-Oncogenes><conditional knock-out><conditional knockout><conventional therapy><conventional treatment><cultured cell line><dental pulp progenitor><dental pulp stem cells><dental pulp stem/progenitor cells><dentin matrix protein 1><dmp1><enzyme linked immunoassay><experiment><experimental research><experimental study><experiments><global health><hRANKL2><heavy metal Pb><heavy metal lead><host response><immune system response><immunoresponse><improved><in vivo><inhibitor><insight><joint arthroplasty><joint replacement><maxilla alveolar process><mechanic><mechanical><mouse genetics><mouse model><murine model><new approaches><novel><novel approaches><novel strategies><novel strategy><pathogenic bacteria><peri-implantitis><periimplantitis><periodontal disorder><periodontal pathogen><periodontium disease><periodontium disorder><periodontopathogen><periopathogen><periopathogenic><pharmacologic><prevent><preventing><protein blotting><pulp stem cells><resection><response><sOdf><sensor><skeletal disease><skeletal disorder><social role><socket wall><teeth><therapeutic target><treatment strategy><v-FOS FBJ Murine Osteosarcoma Viral Oncogene Homolog>
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RYAN RICHARD RUFF

NEW YORK UNIVERSITY, NEW YORK, NY

Exploratory lead · 20/100
Solid budget
Active award
$322,000
FY 2025

Project Title

Improving the design and implementation of school-based oral health programs using secondary data analysis

Grant Number:

1R03DE033776-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2025

End Date:

7/14/2027

Project Abstract

PROJECT SUMMARY Dental caries is the world’s most prevalent noncommunicative disease and negatively impacts child development. Both the NIDCR Oral Health in America report and the World Health Organizations’ Global Oral Health Status report call for improved access to and delivery of effective preve...

Research Terms

<0-11 years old><ANOVA><Access to Care><Address><Affect><Ag element><Analysis of Variance><Anterior><Area><Biostatistics Core><Buccal Cavity><Buccal Cavity Head and Neck><Caries><Caries prevention><Caring><Cavitas Oris><Child><Child Development><Child Youth><Childhood><Children (0-21)><Clinical><Clinical Protocols><Cluster randomization trial><Cluster randomized trial><Critical Care><Data><Data Analyses><Data Analysis><Dental><Dental Care><Dental Decay><Dental Hygienists><Dental Procedure><Dental Sealants><Dental caries><Dentistry><Dentists><Development><Diamines><Disease><Disorder><Dissemination and Implementation><Education><Educational aspects><Electronic Health Record><Emotional><Ensure><Epidemic><Epidemiologist><Face><Fluorides><Health><Health Services Accessibility><Health Status><History><Household><Impairment><Improve Access><Incidence><Individual><Inequity><Infant and Child Development><Investigators><Level of Health><Licensing><Low income><Medical><Minority><Modeling><Mouth><Multivariate Analyses><Multivariate Analysis><NIDCR><NIDR><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><Oral cavity><Oral health><Pain><Painful><Performance><Pit and Fissure Sealants><Prevalence><Prevention><Prevention program><Preventive><Principal Investigator><Probability><Provider><Public Health><Publications><Randomization trial><Recording of previous events><Reporting><Research><Research Personnel><Research Resources><Researchers><Resources><Risk><Rural><School Health Nursing><School Nursing><Schools><Scientific Publication><Scientist><Severities><Silver><Standardization><Surface><Systemic infection><Time><Tooth><Tooth structure><Training><Underserved Population><United States><Variance Analyses><World Health Organization><access to health care><access to health services><access to services><access to treatment><accessibility of health care><accessibility to health care><accessibility to health services><availability of services><barriers to implementation><care access><clinical decision-making><college><collegiate><cost><data interpretation><dental caries prevention><dental health><dental service><design><designing><developmental><disadvantaged background><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><experience><faces><facial><health care access><health care availability><health care service access><health care service availability><health level><health related quality of life><health service access><health services availability><histories><implementation barriers><implementation challenges><implementation research><improved><kids><life span><lifespan><marginalized background><markov model><minimally invasive><new approaches><novel approaches><novel strategies><novel strategy><oral care><pediatric><pragmatic randomized trial><prevent><preventing><programs><psychosocial><randomized trial><real world evidence><restoration><rural area><rural location><rural region><sealant><secondary analysis><semiparametric><service availability><sound><success><teeth><tooth decay><treatment access><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><urban area><urban location><urban region><youngster>
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Neha Singh-Reilly

MAYO CLINIC ROCHESTER, ROCHESTER, MN

Exploratory lead · 20/100
Solid budget
Active award
$320,143
FY 2025

Project Title

Blood plasma metrics as disease biomarkers in atypical Alzheimer's disease

Grant Number:

1R03AG091264-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2025

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY Alzheimer's disease (AD) is a major public health problem affecting an estimated 6.7 million Americans. However, ~25% AD patients present with atypical non-amnestic clinical features such as visual, language, behavioral, executive, or motor difficulties. Furthermore, not all patients...

Research Terms

<A β-42><A β42><A-beta 42><A-beta42><AD dementia><AD detection><AD pathology><Abeta-42><Abeta42><Accuracy of Diagnosis><Address><Affect><Alzheimer Type Dementia><Alzheimer beta-Protein><Alzheimer disease dementia><Alzheimer disease detection><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Amyloid beta-Protein><Alzheimer's Disease><Alzheimer's amyloid><Alzheimer's detection><Alzheimer's diagnosis><Alzheimer's disease diagnosis><Alzheimer's disease pathology><Alzheimer's disease patient><Alzheimer's pathology><Alzheimer's patient><Alzheimers Dementia><American><Amyloid><Amyloid Alzheimer's Dementia Amyloid Protein><Amyloid Beta-Peptide><Amyloid Protein A4><Amyloid Substance><Amyloid beta-42><Amyloid beta-Protein><Amyloid beta42><Amyloid β><Amyloid β-42><Amyloid β-Peptide><Amyloid β-Protein><Amyloid β42><Amyloidβ-42><Amyloidβ42><Astroprotein><Atrophic><Atrophy><Aβ><Aβ-42><Aβ42><Behavioral><Biological Function><Biological Markers><Biological Process><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Brain><Brain Nervous System><Brain region><Clinical><Clinical Trials><Data><Diagnosis><Diagnostic><Diminished Vision><Disease><Disease Marker><Disease Outcome><Disease Progression><Disorder><Dysfunction><Early Diagnosis><Encephalon><Functional disorder><GFA-Protein><GFAP><Glial Fibrillary Acid Protein><Glial Fibrillary Acidic Protein><Glial Intermediate Filament Protein><Goals><Intermediary Metabolism><Language><Light><Low Vision><MR Imaging><MR Tomography><MRI><MRIs><MT-bound tau><Magnetic Resonance Imaging><Measures><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Memory Deficit><Memory Loss><Memory impairment><Metabolic Processes><Metabolism><Mission><Monitor><Motor><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Nuclear Magnetic Resonance Imaging><Outcome><Outcome Measure><PET><PET Scan><PET imaging><PETSCAN><PETT><Partial Sight><Patient Recruitments><Patient Selection><Patients><Performance><Photoradiation><Physiopathology><Plasma><Plasma Serum><Population><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Prevalence><Primary Senile Degenerative Dementia><Proteins><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Rad.-PET><Reduced Vision><Reporting><Research Grants><Research Project Grants><Research Projects><Research Proposals><Reticuloendothelial System, Serum, Plasma><Screening procedure><Sensitivity and Specificity><Subnormal Vision><Syndrome><Time><United States National Institutes of Health><Visual><Visual impairment><Zeugmatography><a beta peptide><abeta><accurate diagnosis><amyloid beta><amyloid-b protein><axon damage><axon injury><axonal damage><axonal injury><beta amyloid fibril><bio-markers><biologic marker><biomarker><brain metabolism><brain volume><clinical phenotype><clinical practice><cohort><diagnostic ability><diagnostic accuracy><diagnostic biomarker><diagnostic capability><diagnostic marker><diagnostic power><diagnostic utility><diagnostic value><disease control><disorder control><early detection><evidence base><improved><inclusion criteria><innovate><innovation><innovative><measurable outcome><memory decline><memory dysfunction><microtubule bound tau><microtubule-bound tau><neural imaging><neural inflammation><neuro-imaging><neurofilament><neuroimaging><neuroimaging biomarker><neuroimaging marker><neuroinflammation><neuroinflammatory><neurological imaging><outcome measurement><p-tau><p-τ><participant recruitment><pathophysiology><patient living with Alzheimer's disease><patient suffering from Alzheimer's disease><patient with Alzheimer's><patient with Alzheimer's disease><phospho-tau><phospho-τ><phosphorylated tau><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><post-translational modification of tau><posttranslational modification of tau><primary degenerative dementia><screening tools><senile dementia of the Alzheimer type><soluble amyloid precursor protein><tau><tau Proteins><tau factor><tau phosphorylation><tau posttranslational modification><tau-1><tool><treatment trial><vision impairment><visually impaired><τ Proteins><τ phosphorylation>
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Rutulkumar Patel

BAYLOR COLLEGE OF MEDICINE, HOUSTON, TX

Exploratory lead · 20/100
Solid budget
Active award
$320,000
FY 2025

Project Title

UNDERSTANDING THE MECHANISMS BEHIND RADIOTHERAPY RESISTANCE OF IMMUNOLOGICALLY COLD HEAD AND NECK CANCER

Grant Number:

1R03DE034506-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2025

End Date:

7/14/2027

Project Abstract

Outcomes have stagnated for patients with locally advanced human papillomavirus (HPV)-negative head & neck squamous cell carcinoma (HNSCC) over the past few decades. Recent studies have shown that ∼15% of all HPV-negative HNSCC patients have altered KEAP1/NFE2L2(NRF2) pathway, which strongly correla...

Research Terms

<Active Oxygen><Address><Antibodies><Antioxidants><Applications Grants><Assay><Bioassay><Biological Assay><Blood granulocytic cell><Blood leukocyte><Bypass><CDDP><CRISPR interference><CRISPR-dCas9-mediated repression><CRISPR/dCas9 interference><CRISPR/dCas9-mediated transcriptional inhibition><CRISPRi><Carcinoma Cell><Cell Body><Cell Communication and Signaling><Cell Line><Cell Signaling><Cell Survival><Cell Viability><CellLine><Cells><Chemicals><Chemotactic Cytokines><Cis-diammine-dichloroplatinum><Cis-diamminedichloridoplatinum><Cis-diamminedichloro Platinum (II)><Cis-dichloroammine Platinum (II)><Cis-platinous Diamine Dichloride><Cis-platinum II><Cis-platinum II Diamine Dichloride><Cisplatin><Cisplatina><Cisplatinum><Clustered Regularly Interspaced Short Palindromic Repeats interference><Collecting Cell><Comet Assay><Cysplatyna><Cytotoxic Chemotherapy><Cytotoxic Therapy><DNA Damage><DNA Damage Repair><DNA Injury><DNA Repair><Data><Dependence><Dichlorodiammineplatinum><Disease><Disorder><Dissociation><Effectiveness><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><GEM model><GEMM model><Gene set enrichment analysis><Genes><Genetic><Genetically Engineered Mouse><Grant Proposals><Granular Leukocytes><Granulocytic cell><HNSCC><HPV(-) HNSCC><HPV(-) head and neck squamous cell carcinoma><HPV- HNSCC><HPV-negative HNSCC><HPV-negative head and neck cancer><HPV-negative head and neck squamous cell carcinoma><Head and Neck Cancer><Head and Neck Carcinoma><Head and Neck Squamous Cell Carcinoma><Homologous Chemotactic Cytokines><Human><Immune mediated therapy><Immunoblotting><Immunochemical Immunologic><Immunofluorescence><Immunofluorescence Immunologic><Immunoglobulin Enhancer-Binding Protein><Immunologic><Immunological><Immunologically><Immunologically Directed Therapy><Immunologics><Immunomodulation><Immunotherapy><In Vitro><Infiltration><Inflammation Mediators><Intercrines><Intracellular Communication and Signaling><Knowledge><Label><Lead><Lesion><Leukocyte Chemotaxis><Leukocytes><Leukocytes Reticuloendothelial System><Leukotaxis><Macrophage><Malignant Cell><Malignant Epithelial Cell><Malignant Head and Neck Neoplasm><Marrow leukocyte><Measures><Mediating><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><Myeloid Cells><Mφ><NF-kB><NF-kappa B><NF-kappaB><NFKB><Nuclear Factor kappa B><Nuclear Transcription Factor NF-kB><Outcome><Oxygen Radicals><PARP Inhibitor><PARP-1 inhibitor><PARPi><Palliative Care><Palliative Therapy><Palliative Treatment><Pathway interactions><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Pb element><Peyrone's Chloride><Peyrone's Salt><Phenotype><Platinum Diamminodichloride><Play><Poly(ADP-ribose) Polymerase Inhibitor><Poly(ADP-ribose) polymerase 1 inhibitor><Primary Neoplasm><Primary Tumor><Pro-Oxidants><Production><Prostaglandins><Prostanoids><RNA Seq><RNA sequencing><RNAseq><Radiation therapy><Radioresistance><Radiosensitization><Radiotherapeutics><Radiotherapy><Reactive Oxygen Species><Research Resources><Resistance><Resources><Role><SCCHN><SIS cytokines><Sampling><Shapes><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Single-Cell Gel Electrophoresis><Slide><Staining method><Stains><Stimulator of Interferon Genes><Strains Cell Lines><Stress><Suspension substance><Suspensions><Technology><Time><Transcription Factor NF-kB><Treatment outcome><Tumor Immunity><Unscheduled DNA Synthesis><Western Blotting><Western Immunoblotting><White Blood Cells><White Cell><advanced disease><advanced illness><anti-tumor immunity><antitumor immunity><biological signal transduction><cGAMP STING><cGAMP-STING><cGAMP/STING><cGAS/STING><cancer cell><cancer cell metabolism><cancer immunity><cancer metabolism><cancer microenvironment><care for patients><care of patients><caring for patients><chemo-/radio-sensitization><chemo-/radio-therapy><chemo-radiotherapy><chemoattractant cytokine><chemokine><chemoradiation><chemoradiation therapy><chemoradiation treatment><chemoradiotherapy><cis dichlorodiammineplatinum><cis platinum compound><cis-Diaminedichloroplatinum><cis-Diamminedichloroplatinum><cis-Diamminedichloroplatinum(II)><cis-Dichlorodiammineplatinum(II)><cis-Platinum><comfort care><cultured cell line><cyclic GMP-AMP synthase/STING><cytokine><degree path><degree pathway><education path><education pathway><flow cytophotometry><genetically engineered mouse model><genetically engineered murine model><granulocyte><head and neck squamous carcinoma><head and neck squamous cell cancer><head/neck cancer><heavy metal Pb><heavy metal lead><human disease><human papillomavirus (-) head and neck squamous cell carcinoma><human papillomavirus - head and neck squamous cell carcinoma><human papillomavirus negative head and neck cancer><human papillomavirus negative head and neck squamous cell carcinoma><human papillomavirus- head and neck squamous cell carcinoma><immune microenvironment><immune modulation><immune regulation><immune resistance><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immune-resistant><immuno therapy><immunogenic><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunoresistance><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><improved><in vivo><in vivo Model><inflammatory mediator><irradiation response><kappa B Enhancer Binding Protein><knock-down><knockdown><loss of function><malignant head and neck tumor><mouse model><murine model><mutant><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapy approaches><new treatment approach><new treatment strategy><non-HPV HNSCC><non-human papillomavirus head and neck squamous cell carcinoma><novel><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapy approach><nuclear factor kappa beta><overexpress><overexpression><palliative intervention><pathway><patient oriented outcomes><protein blotting><protein expression><radiation adverse effect><radiation resistance><radiation response><radiation sensitization><radiation treatment><radio resistance><radio-/chemo-sensitization><radio-chemo-therapy><radio-chemotherapy><radio-sensitization><radiochemotherapy><radiotherapy sensitization><repressing CRISPR-dCas9 system><resistant><response><response to radiation><response to therapy><response to treatment><social role><spatial and temporal><spatial temporal><spatiotemporal><therapeutic response><therapy response><transcriptome sequencing><transcriptomic sequencing><treatment response><treatment responsiveness><treatment with radiation><tumor><tumor cell metabolism><tumor immune microenvironment><tumor metabolism><tumor microenvironment><tumor-immune system interactions><white blood cell><white blood corpuscle>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Rachel O'Conor

NORTHWESTERN UNIVERSITY, CHICAGO, IL

Exploratory lead · 20/100
Solid budget
Active award
$320,000
FY 2025

Project Title

Study to Understand Participant Perspectives On Respite upTake (SUPPORT)

Grant Number:

1R03AG093098-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2027

Project Abstract

ABSTRACT Over 6.9 million people are living with Alzheimer's Disease (AD) and Alzheimer's Disease Related Dementias (ADRD) in the U.S., many of whom rely on family caregivers for activities of daily living. Caregiving to adults with dementia often requires substantial time commitment and personal at...

Research Terms

<21+ years old><AD dementia><AD related dementia><ADRD><Activities of Daily Living><Activities of everyday life><Address><Adult><Adult Human><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Amentia><American><Area><Attention><Automobile Driving><Awareness><Burden on their caregivers><Capsicum><Care Givers><Care giver support><Caregiver Burden><Caregiver support><Caregivers><Caring><Chicago><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive aging><Cognitive decline><Cognitive function abnormal><Cohort Studies><Communities><Community Health Centers><Concurrent Studies><Data><Data Collection><Decision Making><Dementia><Development><Disparities><Disparity><Disturbance in cognition><Economic Income><Economical Income><Ethnic Origin><Ethnicity><Family Care Giver><Family Caregiver><Family member><Funding><Future><Health><Health Benefit><Home><Impaired cognition><Income><Intervention><Interview><Investigators><Link><Longitudinal Studies><Medicaid><Mental Depression><Mental Health><Mental Hygiene><Methods><Neighborhood Health Center><Nursing Homes><Outcome><Participant><Patients><Personal Satisfaction><Persons><Prevalence><Primary Senile Degenerative Dementia><Progressive Disease><Psychological Health><Psychosocial Factor><Public Health><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Reporting><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Schedule><Scientist><Self Care><Self Efficacy><Series><Services><Sleep disturbances><Social Interaction><Special needs><Survey Instrument><Surveys><Time><Training><Universities><aberrant sleep><adulthood><burden in caregivers><burden of their caregivers><burden on caregivers><care giving><care receiver><care recipients><care utilization><caregiving><catalyst><cognitive dysfunction><cognitive loss><cohort><daily living function><daily living functionality><dementia care><depression><developmental><differences in health><disrupted sleep><disturbed sleep><driving><evidence base><functional ability><functional capacity><health difference><health literacy><homes><impaired sleep><incomes><insurance plan><intervention design><irregular sleep><long-term study><longitudinal outcome studies><next generation><nursing home><older adult><older adulthood><pepper><personal care><physical conditioning><physical health><primary care clinician><primary degenerative dementia><psychosocial><psychosocial variables><racial><racial background><racial origin><recruit><respite care><senile dementia of the Alzheimer type><service uptake><service utilization><skills><sleep disruption><sleep dysregulation><sleep/wake disruption><sleep/wake disturbance><social><stress reduction><therapy design><training opportunity><treatment design><uptake><well-being><wellbeing>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Andre L P Tavares

UNIVERSITY OF DELAWARE, Newark, DE

Exploratory lead · 20/100
Solid budget
Active award
$315,289
FY 2025

Project Title

Six1 role on cell fate decisions within the mouse mandibular arch at single-cell resolution.

Grant Number:

1R03DE035162-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2025

End Date:

7/14/2027

Project Abstract

ABSTRACT Many craniofacial structural birth defects result from disrupted formation, migration, patterning, or differentiation of neural crest (NC) cells that populate the pharyngeal arches, including the mandibular arch (first arch). Following patterning, cranial NC cells differentiate into various...

Research Terms

<Affect><Anatomic Abnormality><Anatomical Abnormality><Applications Grants><Auditory Ossicles><BOR Syndrome><Basal Transcription Factor><Basal transcription factor genes><Binding><Birth Defects><Bone Development><Bone Formation><Bone of the Tympanum><Branchial arch structure><Branchio-Oto-Renal Syndrome><Branchio-Otorenal Dysplasia><Branchio-Otorenal Syndrome><Branchiootorenal syndrome><Calvaria><Caring><Cartilage><Cartilaginous Tissue><Cell Body><Cell Communication and Signaling><Cell Culture Techniques><Cell Differentiation><Cell Differentiation process><Cell Signaling><Cells><Cephalic><Chondroblast><Chondrogenesis><Conductive Deafness><Conductive hearing loss><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Connective Tissue><Cranial><Craniofacial Abnormalities><Cues><Cytochemistry Histology><DNA><DNA mutation><Data><Defect><Deformity><Dental><Deoxyribonucleic Acid><Development><Diagnosis><Disease><Disorder><Distal><Dysmorphology><Ear ossicles><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Face><First Pharyngeal Arch><Future><Gene Expression><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic Change><Genetic Transcription><Genetic defect><Genetic mutation><Grant><Grant Proposals><Hearing Loss><Histocytochemistry><Hypoacuses><Hypoacusis><Image><Inferior Maxillary Bone><Internal Ear><Intracellular Communication and Signaling><Jaw><Kidney><Kidney Urinary System><Knock-in><Knock-out><Knockout><Knowledge><Labyrinth><Link><Mandible><Meckel's cartilage><Mice><Mice Mammals><Modeling><Molecular Interaction><Murine><Mus><Mutation><Neural Crest><Neural Crest Cell><Oral><Osteoblasts><Osteogenesis><Otic Placodes><Patients><Pattern><Periosteum><Periosteums><Pharangeal Arch><Phase><Phenotype><Population><Primordium><Proteins><Publishing><RNA Expression><Reporting><Research><Resolution><Role><Signal Transduction><Signal Transduction Systems><Signaling><Skull><Structural Birth Defect><Structural Congenital Anomalies><Structure><Symptoms><Testing><Transcription><Transcription Activator><Transcription Coactivator><Transcription Factor Coactivator><Transcription Factor Proto-Oncogene><Transcription Repressor><Transcription factor genes><Transcriptional Activator/Coactivator><Transcriptional Repressor><Variant><Variation><Visceral Arches><Work><autosome><biological signal transduction><bone><bone tissue formation><branchial arch><calvarial><cartilage development><cell culture><cell cultures><cellular differentiation><co-repressor><cofactor><congenital structural malformation><corepressor><craniofacial><craniofacial anomalies><craniofacial bone><craniofacial defects><craniofacial development><craniofacial malformation><craniofacies><cranium><cytochemistry><developmental><dosage><dysfunctional hearing><experiment><experimental research><experimental study><experiments><faces><facial><gene co-repressor><gene corepressor><genetic co-repressor><genetic corepressor><genetic repressor><genome mutation><hearing challenged><hearing defect><hearing deficient><hearing deficit><hearing difficulty><hearing dysfunction><hearing impairment><histochemistry><histochemistry/cytochemistry><imaging><inner ear><interest><knockin><mandibular><middle ear><migration><novel><osteogenic><pharyngeal arch><population migration><precursor cell><programs><renal><resolutions><response><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><social role><spatial RNA sequencing><spatial gene expression analysis><spatial gene expression profiling><spatial resolved transcriptome sequencing><spatial temporal imaging><spatial temporal mapping><spatial transcriptome analysis><spatial transcriptome profiling><spatial transcriptome sequencing><spatial transcriptomics><spatially resolved transcriptomics><spatio transcriptomics><spatiotemporal imaging><spatiotemporal mapping><tool><transcription factor>
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Ariene Arcas Leme-Kraus

UNIVERSITY OF IOWA, IOWA CITY, IA

Exploratory lead · 20/100
Solid budget
Active award
$311,000
FY 2025

Project Title

Unraveling dentin and enamel roles on the development and progression of wedge-shaped noncarious cervical lesions

Grant Number:

1R03DE034442-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/15/2025

End Date:

7/14/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Noncarious cervical lesions (NCCLs) are a common dental condition that can result in significant loss of tooth structure and pain, affecting the individual throughout their lifetime. Available intervention options for this condition are limited and not effective long-term. T...

Research Terms

<21+ years old><Acids><Adult><Adult Human><Affect><Aging><Approaches to prevention><Area><Bacteria><Basic Research><Basic Science><Binding><Biodegradation><Biomechanics><Bite Force><Body Tissues><CEJ><Cell-Extracellular Matrix><Cementoenamel Junction><Cervical><Cervix Dentis><Characteristics><Clinical><Collagen><Collagen Type I><Collum Dentis><DNA Molecular Biology><Data><Dental><Dental Enamel><Dental Pulp><Dentin><Dentin Formation><Dentin Hypersensitivity><Dentin Sensitivity><Dentition><Development><Diagnostic><ECM><Education><Educational aspects><Elasticity><Electrons><Enamel><Engineering><Extracellular Matrix><Foundations><Funding Mechanisms><Future><Gingival Crevicular Fluid><Gingival Exudate><Goals><Hardness><High Prevalence><Histologic><Histologically><Histology><Hydroxyapatites><IR/UV/Raman Spectroscopy><Immunofluorescence><Immunofluorescence Immunologic><Impairment><Individual><Intervention><Investigators><Knowledge><Lesion><Leucine><Link><MMPs><Masticatory Force><Matrix Metalloproteinases><Minerals><Modeling><Modification><Modulus><Molecular Biology><Molecular Interaction><Morphology><Neck of the Tooth><Negative Beta Particle><Negatrons><Occlusal Force><Odontalgia><Oral health><Pain><Painful><Patients><Play><Population><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Prevalence><Preventative therapy><Prevention approach><Preventive><Preventive therapy><Property><Protein Modification><Proteins><Proteoglycan><Proteomics><R-Series Research Projects><R01 Mechanism><R01 Program><Raman Spectroscopy><Raman Spectrum Analysis><Raman imaging><Raman spectrometry><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Roentgen Rays><Role><Scanning><Shapes><Spatial Distribution><Stress><Testing><Therapeutic><Therapeutic Intervention><Tissues><Tooth><Tooth Cervix><Tooth Loss><Tooth structure><Toothache><Toothbrushing><Type 1 Collagen><X-Radiation><X-Ray Radiation><X-ray><Xray><adult youth><adulthood><biomechanical><bite strength><clinical translation><clinically translatable><customized therapy><customized treatment><dental health><dental pain><dental structure><dentalgia><developmental><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><innovate><innovation><innovative><intervention therapy><mechanical properties><micrography><mineralization><nano><nano indentation><nano mechanics><nano meter scale><nano meter sized><nanoindentation><nanomechanics><nanometer scale><nanometer sized><nanoscale><older adult><older adulthood><patient specific therapies><patient specific treatment><prevent><preventing><pulp><repair><repaired><social role><sound><success><tailored medical treatment><tailored therapy><tailored treatment><teeth><tool><tooth brushing><tooth enamel><tooth pain><translational goal><translational investigator><translational mission><translational researcher><translational scientist><unique treatment><young adult><young adult age><young adulthood>
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Tychele Naomi Turner

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 20/100
Solid budget
Active award
$311,000
FY 2024

Project Title

A Comprehensive De Novo Variant Callset for the Gabriella Miller Kids First Pediatric Research Program Birth Defect Data

Grant Number:

1R03HD116062-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2026

Project Abstract

Project Summary/Abstract Birth defects occur in 1 in 33 individuals and result in yearly healthcare costs in the United States of America of >$23 billion. Understanding genetic causes of birth defects can provide insights into molecular pathways and ultimately provide a path towards therapeutics. Th...

Research Terms

<0-11 years old><ASD><Acceleration><Address><Autism><Autistic Disorder><Birth Defects><Cancers><Child><Child Youth><Children (0-21)><Chimp><Chimpanzee><Code><Coding System><Collection><Communities><Computational toolkit><Congenital Abnormality><Congenital Anatomical Abnormality><Congenital Defects><Congenital Deformity><Congenital Malformation><Congenital diaphragmatic hernia><Craniosynostosis><Data><Data Set><Detection><Early Infantile Autism><Event><Family><Functional RNA><Future><Generations><Genes><Genetic><Genome><Genomics><Grant><Haplogroup><Health Care Costs><Health Care Systems><Health Costs><Healthcare Costs><Healthcare Systems><Human><Individual><Infantile Autism><Investigators><Kanner's Syndrome><Literature><Malignant Neoplasms><Malignant Tumor><Mitochondria><Modern Man><Molecular><Names><Neural Tube Defects><Neural Tube Developmental Defects><Non-Coding><Non-Coding RNA><Non-translated RNA><Noncoding RNA><Nontranslated RNA><Nuclear><Outcome><Pan Genus><Pan Species><Parents><Pathway interactions><Pediatric Research><Phenotype><Prevalence><Proteins><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Sequence Alignment><Speed><Structural defect><Structural malformation><Testing><Therapeutic><United States><Untranslated RNA><Variant><Variation><Work><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><cohort><computational toolbox><computational tools><computational toolset><computerized tools><data exploration><data portal><data sharing portal><de novo mutation><de novo variant><entire genome><full genome><genome sequencing><heteroplasmy><human disease><insight><interest><kids><malignancy><mitochondrial><mitochondrial genome><name><named><naming><neoplasm/cancer><noncoding><orofacial cleft><orofacial clefting><parent><pathway><programs><response><sequencing alignment><structural abnormalities><structural anomalies><tool><whole genome><youngster>
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Lifeng Lin

UNIVERSITY OF ARIZONA, TUCSON, AZ

Exploratory lead · 20/100
Solid budget
Active award
$301,417
FY 2025

Project Title

Innovative Data Integration Models for Handling Evidence Inconsistency in AD/ADRD Research

Grant Number:

1R03AG093555-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

4/30/2027

Project Abstract

PROJECT SUMMARY This R03 proposal, responding to PAR-23-179, aims to advance evidence-based practice by developing innovative methods and tools for integrating data from AD/ADRD studies. Our focus is on addressing challenges posed by inconsistencies among evidence from different studies, specificall...

Research Terms

<AD dementia><AD related dementia><ADRD><Address><Adoption><Age><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimer's and related dementias><Alzheimer's dementia and related dementia><Alzheimer's dementia or related dementia><Alzheimer's disease and related dementia><Alzheimer's disease and related disorders><Alzheimer's disease or a related dementia><Alzheimer's disease or a related disorder><Alzheimer's disease or related dementia><Alzheimer's disease related dementia><Alzheimers Dementia><Area><Award><Bayesian Method><Bayesian Methodology><Bayesian Modeling><Bayesian Statistical Method><Bayesian adaptive designs><Bayesian adaptive models><Bayesian approaches><Bayesian belief network><Bayesian belief updating model><Bayesian classification method><Bayesian classification procedure><Bayesian framework><Bayesian hierarchical model><Bayesian network model><Bayesian nonparametric models><Bayesian posterior distribution><Bayesian spatial data model><Bayesian spatial image models><Bayesian spatial models><Bayesian statistical models><Bayesian tracking algorithms><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biometrics><Biometry><Biostatistics><Causality><Characteristics><Chronic><Clinical><Clinical Investigator><Clinical Research><Clinical Study><Comparative Effectiveness Research><Complex><Computer software><Conditioning Therapy><Decision Making><Dedications><Development><Disease><Disorder><Effectiveness><Effectiveness of Interventions><Etiology><Evidence based intervention><Evidence based practice><Evidence based treatment><Exhibits><Funding Opportunities><Gender><Goals><Health Care><Heterogeneity><Intervention><Investigators><Measurement><Medicine><Mental Health><Mental Hygiene><Meta-Analysis><Methodology><Methods><Modeling><Nature><Non-pharmacologic Therapy><Nonpharmacologic Intervention><Nonpharmacologic Therapy><Nonpharmacologic approach><Nonpharmacologic treatment><Outcome><Output><Pain Control><Pain Therapy><Pain management><Patient Care><Patient Care Delivery><Patients><Peer Review><Performance><Pilot Projects><Population Characteristics><Preventative strategy><Prevention strategy><Preventive strategy><Primary Senile Degenerative Dementia><Psychological Health><Publications><Publishing><Race><Races><Research><Research Personnel><Researchers><Sample Size><Scientific Publication><Scientist><Software><Statistical Methods><Techniques><Uncertainty><Work><advanced analytics><ages><behavior intervention><behavioral intervention><care for patients><care of patients><career><caring for patients><causation><clinical decision-making><clinical practice><comparative><comparative effectiveness><conference><convention><data integration><design><designing><develop software><developing computer software><developmental><disease causation><disparity in health><doubt><evidence base><health disparity><improved><innovate><innovation><innovative><intervention effect><network models><new approaches><non-drug therapy><non-drug treatment><nondrug therapy><nondrug treatment><novel><novel approaches><novel strategies><novel strategy><older adult><older adulthood><open source><pain intervention><pain treatment><patient population><pilot study><primary degenerative dementia><programs><racial><racial background><racial origin><recruit><senile dementia of the Alzheimer type><simulation><software development><statistic methods><statistics><success><summit><symposia><symposium><systematic review><tool><treatment strategy><user friendly computer software><user friendly software><user-friendly>
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Yanbin Yin

UNIVERSITY OF NEBRASKA LINCOLN, LINCOLN, NE

Exploratory lead · 20/100
Solid budget
Active award
$294,432
FY 2025

Project Title

Glycan Utilization Profiling in Human Gut Microbiomes of Common Funds Data

Grant Number:

1R03OD039979-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/10/2025

End Date:

1/31/2027

Project Abstract

Glycan Utilization Profiling in Human Gut Microbiomes of Common Funds Data Healthy diets are key to prevent various metabolic diseases (e.g., cardiovascular disease, intestinal bowel disease, and obesity). The western diets are known to be unhealthy as it lacks sufficient dietary fibers, which are c...

Research Terms

<3-D><3-Dimensional><3D><AI language models><Africa><African><Allergy><American><Autoimmune Diseases><Bacterial Genome><Bioinformatics><Carbohydrates><Cardiovascular Diseases><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chronic><Code><Coding System><Colon><Complex><Computer software><Consumption><Data><Data Bases><Data Set><Databases><Diet><Dietary Fiber><Dietary Intervention><Disease><Disorder><Documentation><Ecologic Systems><Ecological Systems><Ecosystem><Environment><Enzyme Gene><Enzymes><Family><Fiber><Friends><Functional Metagenomics><Funding><GI microbiome><Gene Cluster><Gene Transcription><Genetic Transcription><Genome><Glycans><Health><Health Benefit><Healthy diet><Heredity><Human><Human Microbiome><Individual><Industry><Inflammatory Bowel Diseases><Inflammatory Bowel Disorder><Intestinal><Intestines><Intracellular Communication and Signaling><Inulin><Life Style><Lifestyle><Maps><Martens><Martes><Metabolic Diseases><Metabolic Disorder><Metagenomics><Modern Man><NIH><Names><National Institutes of Health><Nutrition Interventions><Nutritional Interventions><Obesity><Patients><Persons><Play><Polysaccharides><Population><Prevalence><Proteins><RNA Expression><Research><Role><Sampling><Short-Chain Fatty Acids><Signal Transduction><Signal Transduction Systems><Signaling><Software><Structural Models><Thesaurismosis><Transcription><Transformer language model><US Department of Agriculture><USDA><United States Department of Agriculture><United States National Institutes of Health><Update><Volatile Fatty Acids><adiposity><artificial intelligence language models><autoimmune condition><autoimmune disorder><autoimmunity disease><bacteria in the gut><balanced diet><bio-informatics tool><bioinformatics tool><biological signal transduction><bowel><cardiovascular disorder><corpulence><data base><deep learning><deep learning method><deep learning strategy><diet intervention><dietary><diets><digestive tract microbiome><disease prevention><disorder prevention><enteric microbiome><extracellular><gastrointestinal microbiome><good diet><gut bacteria><gut health><gut metagenome><gut microbiome><gut-associated microbiome><human-associated microbiome><individualized nutrition><inflammatory disease of the intestine><inflammatory disorder of the intestine><innovate><innovation><innovative><intestinal autoinflammation><intestinal biome><intestinal microbiome><large language model><large scale language model><massive scale language models><metabolism disorder><metagenome><metatranscriptomics><microbiome><microbiome community composition><microbiome composition><microbiome sequencing><microbiome species composition><microbiome structure><microbiota derived metabolites><microbiota metabolites><multiomics><multiple omics><name><named><naming><panomics><personalized nutrition><prebiotics><prevent><preventing><programs><social role><sugar><three dimensional><western diet><western-style diet><western-type diet><whole grain>
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Katherine Scovner Ravi

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 20/100
Solid budget
Active award
$268,500
FY 2025

Project Title

Incident Hemodialysis Electrolyte Analysis and Rhythm Trends (IHEART)

Grant Number:

1R03DK144241-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/11/2025

End Date:

8/31/2027

Project Abstract

Project Summary/Abstract This R03 award will contribute to providing Dr. Katherine Ravi with the resources, additional training and protected time necessary to achieve her goal of becoming an independent clinical investigator. Dr. Ravi has completed her Master of Public Health and will continue to ...

Research Terms

<Arrhythmia><Asystole><Award><Biometrics><Biometry><Biostatistics><Blood Serum><Calcium><Cardiac><Cardiac Arrest><Cardiac Arrhythmia><Cardiac Electrophysiologic Techniques><Cardiac Electrophysiological Diagnostics><Cardiac Muscle Cells><Cardiac Myocytes><Cardiocyte><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Caring><Causality><Cell Communication and Signaling><Cell Signaling><Clinical Investigator><Cohort Studies><Complement><Complement Proteins><Complex><Concurrent Studies><Data><Death Rate><Dialysis><Dialysis procedure><Dropout><ECG><EKG><Education><Educational aspects><Electrocardiogram><Electrocardiography><Electrolyte Balance><Electrolytes><Etiology><Event><Follow-Up Studies><Followup Studies><Foundations><Frequencies><Funding><Future><General Population><General Public><Goals><Heart Arrest><Heart Arrhythmias><Heart Muscle Cells><Heart Vascular><Heart myocyte><Hemodialyses><Hemodialysis><Holter Electrocardiography><Holter Monitoring><Holtmon><Hospitals><Hour><Human><Hypocalcemia><Institution><Intracellular Communication and Signaling><Investigation><Kidney Diseases><Leadership><M.P.H.><Maintenance><Master of Public Health><Measures><Medical><Mentorship><Metabolic><Modern Man><Morphology><Nephropathy><Outcome><Patients><Pattern><Persons><Phase><Physiologic><Physiological><Premature Ventricular Beats><Premature Ventricular Contractions><Procedures><Prospective, cohort study><Renal Disease><Research><Research Design><Research Resources><Resources><Risk><Science><Serum><Serum Calcium Level><Signal Transduction><Signal Transduction Systems><Signaling><Study Type><Sudden Death><Symptoms><Time><Training><United States><Ventricular><Ventricular Ectopic Beats><Ventricular Extrasystole><Ventricular Premature Complexes><Ventricular Premature Complices><Ventricular Tachycardia><Woman><biological signal transduction><cardiac electrophysiology><cardiac rhythm><cardiomyocyte><catalyst><causation><circulatory system><clinical investigation><complementation><conference><convention><death risk><dialysis therapy><disease causation><heart electrophysiology><heart rate variability><heart rhythm><improved><innovate><innovation><innovative><ionization><kidney disorder><mortality><mortality rate><mortality ratio><mortality risk><patient population><preservation><programs><recruit><renal disorder><responsible research conduct><skills><study design><sudden cardiac death><summit><symposia><symposium><trend>
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Robynne Braun

UNIVERSITY OF MARYLAND BALTIMORE, BALTIMORE, MD

Exploratory lead · 20/100
Solid budget
Active award
$252,000
FY 2024

Project Title

Transcriptional Profiling of the Post-Stroke Immune Response to Tailor Rehabilitation Timelines

Grant Number:

1R03HD114143-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT This R03 proposal is for a 2-year multidisciplinary research project that spans the fields of stroke rehabilitation and stroke genomics. The central premise in this research is that the transcriptional profiles of circulating immune cells (peripheral blood mononuclear cells,...

Research Terms

<Address><Animal Model><Animal Models and Related Studies><Animals><Apoplexy><Area><Award><Biological><Biological Function><Biological Markers><Biological Process><Blood><Blood - brain barrier anatomy><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Blood Reticuloendothelial System><Blood monocyte><Blood-Brain Barrier><Brain Vascular Accident><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Communication and Signaling><Cell Differentiation><Cell Differentiation process><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Signaling><Cells><Cellular Proliferation><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Chemotaxis><Chronology><Communities><Corticospinal Tracts><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><Cytoskeletal Modeling><Cytoskeletal Organization><Cytoskeletal Organization Process><Cytoskeletal Reorganization><Data><Differential Gene Expression><Disabled Persons><Disabled Population><Disease Frequency Surveys><Event><Expression Signature><Extremities><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Funding><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profile><Gene Expression Profiling><Gene Transcription><Genes><Genetic Research><Genetic Transcription><Genomic medicine><Genomics><Goals><Handicapped><Hemato-Encephalic Barrier><Hour><Immune><Immune response><Immunes><Immunochemical Immunologic><Immunologic><Immunological><Immunological response><Immunologically><Immunologics><Individual><Inflammation><Interdisciplinary Research><Interdisciplinary Study><Intervention><Intervention Strategies><Intracellular Communication and Signaling><Investigators><Ischemic Stroke><Limb structure><Limbs><Literature><Lymphatic cell><Lymphocyte><Lymphocytic><Marrow Neutrophil><Marrow monocyte><Maryland><Measures><Medical Rehabilitation><Medical Research><Methodology><Methods><Molecular><Motor><Motor Evoked Potentials><Multidisciplinary Collaboration><Multidisciplinary Research><NGS Method><NGS system><NIH><National Institutes of Health><Nervous System Diseases><Nervous System Disorder><Neuro rehabilitation><Neurologic Disorders><Neurological Disorders><Neurorehabilitation><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Non-Trunk><PBMC><Pathway interactions><Patients><Pattern><People with Disabilities><Peripheral><Peripheral Blood Mononuclear Cell><Personalized medical approach><Persons with Disabilities><Phase><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Pre-Clinical Model><Preclinical Models><Public Health><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><RNA Expression><RNA Seq><RNA sequencing><RNAseq><Recovery><Rehabilitation><Rehabilitation therapy><Research><Research Design><Research Grants><Research Personnel><Research Priority><Research Project Grants><Research Projects><Research Resources><Researchers><Resources><Semaphorins><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Stroke><Study Type><System><Technology><Time><Tissue-Specific Differential Gene Expression><Tissue-Specific Gene Expression><Transcript><Transcript Expression Analyses><Transcript Expression Analysis><Transcription><United States National Institutes of Health><Universities><VEGF><VEGFs><Vascular Endothelial Growth Factors><WNT Signaling Pathway><WNT signaling><Work><Xenopus B2 antigen><acute cerebrovascular accident><acute stroke><after stroke><analyze gene expression><bio-markers><biologic><biologic marker><biological signal transduction><biomarker><biomarker discovery><bloodbrain barrier><brain attack><brain tissue><career><cell type><cellular differentiation><cerebral vascular accident><cerebrovascular accident><database of Genotypes and Phenotypes><dbGaP><differential expression><differentially expressed><disabled individual><disabled people><flow cytophotometry><functional outcomes><gene expression analysis><gene expression assay><gene expression pattern><gene expression signature><genome repository><genomic data><genomic data-set><genomic dataset><genomic repository><host response><immune system response><immunoresponse><individualized approach><individuals with disabilities><innovate><innovation><innovative><interventional strategy><lymph cell><model of animal><monocyte><motor impairment><motor recovery><movement impairment><movement limitation><neural inflammation><neural repair><neuroinflammation><neuroinflammatory><neurological disease><neurological rehab><neurological rehabilitation><neurorehab><neurorehabilitative><neutrophil><next gen sequencing><next generation sequencing><nextgen sequencing><novel><optimal therapies><optimal treatments><pathway><peripheral blood><personalization of treatment><personalized approach><personalized medicine><personalized therapy><personalized treatment><phenotypic data><plexin><post stroke><poststroke><precision approach><predictive biomarkers><predictive marker><predictive molecular biomarker><programs><public health relevance><recruit><rehab research><rehab therapy><rehabilitation after stroke><rehabilitation research><rehabilitative><rehabilitative therapy><response><response to therapy><response to treatment><stroke outcome><stroke recovery><stroke rehab><stroke rehabilitation><stroked><strokes><study design><tailored approach><therapeutic response><therapy response><timeline><transcriptional differences><transcriptional profile><transcriptional profiling><transcriptional signature><transcriptome sequencing><transcriptomic sequencing><transcriptomics><treatment response><treatment responsiveness>
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William James Deardorff

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 18/100
Active award
Career award
$243,000
FY 2025

Project Title

Enhancing prognosis communication for older adults in skilled nursing facilities

Grant Number:

1K76AG094730-01

Activity Code:

K76

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

8/15/2025

End Date:

7/31/2030

Project Abstract

PROJECT SUMMARY/ABSTRACT This is an application for a Beeson K76 award for Dr. James Deardorff, a geriatrician and Assistant Professor at the University of California, San Francisco. Dr. Deardorff's career goal is to become an independent investigator focused on trialing methods to optimize prognos...

Research Terms

<Acute><Address><Admission><Admission activity><Award><Awareness><Calibration><California><Care Manager><Caring><Case Manager><Clinical><Cognitive Discrimination><Communication><Communication Tools><Complex><Data><Decision Making><Dedications><Development><Discrimination><Educational process of instructing><Ensure><Extended Care Facilities><Focus Groups><Future><Goals><Health><Health Care Facility><Health Facilities><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Home><Home Nursing Care><Hospices><Hospital Admission><Hospitalization><Hospitals><Intervention><Interview><Investigators><Knowledge><Leadership><Logistic Regressions><Long-Term Care><Machine Learning><Measures><Medical Rehabilitation><Medicare><Mentors><Methods><Modeling><Morality><Non-Professional Home Care><Non-Professional Homecare><Nonprofessional Home Care><Nonprofessional Homecare><Nurses><Nursing Homecare><Nursing Homes><Outcome><Palliative Care><Palliative Therapy><Palliative Treatment><Participant><Patient Care><Patient Care Delivery><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Physicians><Pilot Projects><Predicting Risk><Probability><Prognosis><Qualitative Methods><Qualitative Research><Randomized><Recommendation><Recovery><Recovery of Function><Rehabilitation><Rehabilitation therapy><Research Personnel><Research Resources><Researchers><Resources><Risk Estimate><San Francisco><Self Efficacy><Skilled Nursing Facilities><Structure><Teaching><Time><Title 18><Training><Uncertainty><Universities><Vulnerable Populations><Writing><acceptability and feasibility><acute care><adverse event risk><arm><assess effectiveness><care facilities><care for patients><care of patients><care partner><care preference><career><career development><caregiving partner><caring for patients><clinical care><comfort care><computer based prediction><determine effectiveness><developmental><doubt><effectiveness assessment><effectiveness evaluation><effectiveness testing><evaluate effectiveness><evidence base><examine effectiveness><expectation><experience><extended care><forecasting risk><functional recovery><health insurance for disabled><high risk><homes><hospice environment><hospital re-admission><hospital readmission><implementation science><improved><informant><machine based learning><machine learning based method><machine learning based model><machine learning method><machine learning methodologies><machine learning model><moralities><mortality><neural network><novel><nurse><nursing home><older adult><older adulthood><palliative intervention><participant engagement><patient engagement><patient oriented outcomes><payment><pilot study><pilot test><pragmatic effectiveness trial><pragmatic trial><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive modeling><predictive risk><predicts risk><preference><professor><prognosis model><prognostic><prognostic model><qualitative reasoning><random forest><randomisation><randomization><randomized, clinical trials><randomly assigned><re-admission><re-hospitalization><readmission><recruit><rehab therapy><rehabilitative><rehabilitative therapy><rehospitalization><risk prediction><risk predictions><shared decision making><skills><tool><trial design><vulnerable group><vulnerable individual><vulnerable people>
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Wade William Sugden

VERSITI BLOOD HEALTH, INC., MILWAUKEE, WI

Exploratory lead · 16/100
Active award
$127,500
FY 2026

Project Title

Role of Force-directed Lipid Metabolism in the Endothelial-to-Hematopoietic Transition

Grant Number:

1R03DK145931-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/5/2026

End Date:

12/31/2027

Project Abstract

Project Summary/Abstract In vertebrates, self-renewing hematopoietic stem cells (HSCs) are produced from a developmental event called endothelial-to-hematopoietic transition (EHT). EHT consists of a cellular and transcriptional reprogramming that allows hemogenic endothelial cells (HECs) from a subs...

Research Terms

<Ablation><Agonist><Anemia><Animal Genetics><Animal Model><Animal Models and Related Studies><Aorta><Arteries><Atlases><Basal Transcription Factor><Basal transcription factor genes><Biologic Models><Biological Models><Blood><Blood Cells><Blood Circulation><Blood Diseases><Blood Precursor Cell><Blood Reticuloendothelial System><Blood Vessels><Blood flow><Bloodstream><Body Tissues><Brachydanio rerio><Cardia><Cardiac development><Cell Body><Cell Communication and Signaling><Cell Cycle><Cell Division Cycle><Cell Lineage><Cell Nucleus><Cell Reprogramming><Cell Signaling><Cells><Cessation of life><Characteristics><Chemicals><Circulation><Clinical><Complex><Confocal Microscopy><Cues><Cyclicity><Danio rerio><Data><Data Set><Death><Defect><Development><Developmental Process><Discipline><Distant><Dorsal><Edg Receptors><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Artery><Embryonic Development><Embryonic arterial structure><Endothelial Cells><Endothelium><Endowment><Erythroid Cells><Event><Exhibits><Exposure to><Failure><Future><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Generations><Genes><Genetic><Genetic Transcription><Glycolysis><Growth><HSC emergence><HSC production><HSC transplantation><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic><Hematopoietic Cell Production><Hematopoietic Cell Tumor><Hematopoietic Cellular Control Mechanisms><Hematopoietic Malignancies><Hematopoietic Neoplasms><Hematopoietic Neoplasms including Lymphomas><Hematopoietic Progenitor Cells><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Hematopoietic Tumor><Hematopoietic and Lymphoid Cell Neoplasm><Hematopoietic and Lymphoid Neoplasms><Hematopoietic stem cells><Hereditary><Image><Impairment><In Vitro><Inherited><Intermediary Metabolism><Intracellular Communication and Signaling><Investigators><Knock-out><Knockout><Lipids><Lymphatic cell><Lymphocyte><Lymphocytic><Lymphoid Cell><Malignant Hematopoietic Neoplasm><Mammalia><Mammals><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Mediating><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Mice><Mice Mammals><Model System><Modeling><Molecular><Molecular Genetics><Morphogenesis><Murine><Mus><Myeloid Cells><Nature><Neural Development><Nucleus><Nutrient><Nutritional><Oxidative Phosphorylation><Oxidative Phosphorylation Pathway><Pathway interactions><Patients><Periodicity><Peripheral Blood Cell><Population><Process><Production><Progenitor Cell Transplantation><Progenitor Cells><Proteins><Protocol><Protocols documentation><Proxy><Publishing><RNA Expression><Receptor Protein><Regulation><Research Personnel><Researchers><Resolution><Rhythmicity><Role><S1P Receptor><Sampling><Series><Signal Induction><Signal Transduction><Signal Transduction Systems><Signaling><Sorting><Specific qualifier value><Specified><Sphingosine-1-Phosphate Receptor><Stem Cell Transplantation><Stem cell transplant><Stimulus><Stretching><System><Techniques><Technology><Testing><Therapeutic><Time><Tissue Growth><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transducers><Transplantation><Vertebrate Animals><Vertebrates><Visualization><Wound Repair><Zebra Danio><Zebra Fish><Zebrafish><angiogenesis><antagonism><antagonist><biological signal transduction><blood cancer><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood stem cell emergence><blood stem cell transplantation><blood-forming stem cell><cancer of blood><cancer of the blood><candidate identification><cardiogenesis><cell fate specification><cell type><cellular reprogramming><cost><curative intervention><curative therapeutic><curative therapy><curative treatments><developmental><emergence of hematopoietic stem cells><fat metabolism><gain of function><gastric cardia><gene function><gene regulatory network><genome editing><genomic editing><global gene expression><global transcription profile><heart development><heart formation><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic gene><hematopoietic hierarchy><hematopoietic progenitor><hematopoietic progenitor cell transplantation><hematopoietic stem cell emergence><hematopoietic stem cell production><hematopoietic stem progenitor cell><hemodynamics><hemogenic endothelium><hemopoietic><hemopoietic progenitor><hemopoietic stem cell><hiPSC><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><iPS><iPSC><iPSCs><imaging><in vivo><induced human pluripotent stem cells><induced pluripotent cell><induced pluripotent stem cell><inducible pluripotent cell><inducible pluripotent stem cell><interest><leukemia/lymphoma><lipid mediator><lipid metabolism><lipidome><lipidomics><loss of function><lymph cell><lymphoma/leukemia><mechanical force><metabolic profile><migration><model of animal><model organism><monolayer><morphogenetic process><mouse model><multipotency><multipotent><murine model><mutant><neurodevelopment><nutritious><ontogeny><organ development><organ growth><overexpress><overexpression><pathway><progenitor><progenitor transplantation><receptor><reconstitute><reconstitution><resolutions><response><self-renew><self-renewal><social role><sphingosine 1-phosphate><stem and progenitor cell transplantations><stem cells><stomach cardia><success><tool><trait><transcription factor><transcriptional reprogramming><transcriptome><transcriptomics><transplant><vascular><vertebrata><vertebrate embryos><wound healing><wound recovery><wound resolution><zebrafish genome>
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Jacqueline Anne Seiglie

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 16/100
Active award
$123,750
FY 2026

Project Title

Audible diabetesRx: An audio-based digital tool to address health literacy barriers to medication adherence in type 2 diabetes

Grant Number:

1R03DK145781-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/4/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY Background: Latino adults in the U.S. have higher prevalence of type 2 diabetes (T2D) and mean HbA1c and are nearly twice as likely to report suboptimal adherence to diabetes medications as non-Hispanic White individuals. Low heath literacy (prevalent among ~40% of U.S. Latino adults...

Research Terms

<21+ years old><5th grade><Address><Adherence><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Chronic><Communication challenge><Communication difficulty><Communities><Complications of Diabetes Mellitus><Data><Diabetes Complications><Diabetes Mellitus><Diabetes-Related Complications><Diabetic Complications><Diminished Vision><Dose><Drugs><Education><Educational aspects><English Language><Enrollment><Espanol><Feedback><Focus Groups><Future><Glycohemoglobin A><Glycosylated hemoglobin A><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Hemoglobin A(1)><High Prevalence><Individual><Intervention><Ketosis-Resistant Diabetes Mellitus><Knowledge><Label><Language><Latino><Latino Population><Latino group><Latino individual><Latino people><Latinos><Low Vision><Maturity-Onset Diabetes Mellitus><Medication><Methodology><NIDDM><Non-Hispanic><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Nonhispanic><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Not Hispanic or Latino><Parents><Partial Sight><Participant><Patients><Persons><Pharmaceutical Preparations><Pharmacies><Pharmacists><Pharmacy facility><Population><Questionnaires><Reader><Reading><Recommendation><Reduced Vision><Regimen><Reporting><Research><Role><SMS support><Self Efficacy><Self Management><Self Medication><Slow-Onset Diabetes Mellitus><Spanish><Speech><Stable Diabetes Mellitus><Subnormal Vision><T2 DM><T2D><T2DM><Techniques><Technology><Testing><Text><Text Messaging><Titrations><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><Visual impairment><Writing><acceptability and feasibility><adult onset diabetes><adulthood><behavior adherence><behavioral adherence><compliance behavior><design><designing><determine efficacy><diabetes><diabetes management><diabetes mellitus management><diabetes self-care><diabetes self-management><diabetic management><digital><digital health><digital tool><digital toolkit><drug adherence><drug compliance><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><enroll><evaluate efficacy><examine efficacy><fifth grade><glycemic control><health IT><health information technology><health literacy><hemoglobin A1c><improved><inadequate health literacy><intervention refinement><ketosis resistant diabetes><literacy><low health literacy><maturity onset diabetes><medication adherence><medication compliance><mortality><novel><parent><participant enrollment><patient centered><patient enrollment><patient oriented><poor health literacy><prototype><recruit><reduced health literacy><retention rate><retention strategy><secondary outcome><short message service><side effect><sms messaging><social role><support tools><text based support><text messaging support><texting><texting support><tool><type 2 DM><type II DM><type two diabetes><usability><user centered design><vision impairment><visually impaired>
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Kim Hung Ho Liss

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 16/100
Active award
$116,625
FY 2026

Project Title

Novel Use of Fomepizole in Hepatic Ischemia Reperfusion Injury

Grant Number:

1R03DK145778-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2026

End Date:

1/31/2028

Project Abstract

PROJECT SUMMARY/ABSTRACT The demand for liver transplantation far exceeds the number of suitable donor organs. Despite the organ shortage, due to increased risk for ischemia reperfusion injury (IRI), many marginal donor livers with steatosis go unused. While some IRI is unavoidable in all liver oper...

Research Terms

<1,2-Ethanediol><2-Hydroxyethanol><4-Nitrophenol-2-Hydroxylase><4-methylpyrazole><ALT1><APAP><APAP hepatotoxicity><APAP-induced liver injury><Acetamidophenol><Acetaminophen><Acetominophen><Address><Alanine Aminotransferase><Alanine Transaminase><Alanine-2-Oxoglutarate Aminotransferase><Alcohol dehydrogenase><Alcohol-NAD+ Oxidoreductase><Allografting><Attenuated><Blood flow><C-jun Amino-Terminal Kinase><C-jun Kinase-1><C-jun N-Terminal Kinase 1><CPE1><CYP 2E1><CYP IIE1><CYP2E><CYP2E1><CYP2E1 gene><CYPE1><CYPIIE1><Case Study><Case-Base Studies><Cell Death><Cellular injury><Cessation of life><Clinical><Collaborations><Common Rat Strains><Cryofixation><Cryopreservation><Cytochrome P-450 CYP2E1><Cytochrome P-450 IIE1><Cytochrome P-450-J><Cytochrome P450 2E1><Cytochrome P450, Family 2, Subfamily E, Polypeptide 1><Cytochrome P450, subfamily Ethanol-Inducible, Polypeptide 1><Data><Death><Development><Dihydroxyethanes><Dimethylnitrosamine N-Demethylase><Drug Therapy><Drug usage><Dysfunction><Elderly><Ethanediols><Ethanol-Inducible P450><Ethylene Glycols><FDA licensed drugs><FDA-approved agents><FDA-approved drug><FDA-approved medications><FDA-approved pharmaceuticals><FDA-approved therapeutic agent><Fats><Fatty acid glycerol esters><Food and Drug Administration approved drug><Food and Drug Administration approved medications><Food and Drug Administration approved pharmaceuticals><Functional disorder><Funding Mechanisms><Glutamic-Alanine Transaminase><Glutamic-Pyruvate Transaminase><Glutamic-Pyruvic Transaminase><Goals><Hepatic Disorder><Hepatic Transplantation><Hepatology><Hepatotoxic effect><Hepatotoxicity><Histologic><Histologically><Hydroxyacetanilide><Hypothermia><In Vitro><Inflammation><Inflammatory Response><Injury><Injury to Liver><Interruption><Ischemia><Ischemia-Reperfusion Injury><Isolated Perfusion><Isolation Perfusion><Isolation Perfusion Therapy><JN Kinase><JNK><JNK Mitogen-Activated Protein Kinases><JNK1><JNK1 Kinase><JNK1 protein><JNK1A2><JNK21B1/2><Kinases><Learning><Lipids><Liver><Liver Grafting><Liver Toxicity><Liver Transplant><Liver diseases><MAP Kinase 8><MAP Kinase 8 Gene><MAPK8><MAPK8 Mitogen-Activated Protein Kinase><MAPK8 gene><Metabolic dysfunction><Metabolic stress><Mitogen-Activated Protein Kinase 8><Modeling><Molecular><Monoethylene Glycol><Morbidity><N-Nitrosodimethylamine Demethylase><N-terminal><NH2-terminal><Obesity><Organ><Organ Donor><Organ Preservation><Outcome><Oxidative Stress><P450-2E1><P450-J><P450C2E><PRKM8><Paracetamol><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Perfusion><Pharmacological Treatment><Pharmacotherapy><Phase><Phosphotransferase Gene><Phosphotransferases><Physiopathology><Poisoning><Predisposition><Preservation Technique><Prevalence><Property><Rat><Rats Mammals><Rattus><Regional Perfusion><Reperfusion Damage><Reperfusion Injury><Reperfusion Therapy><Research Proposals><Risk><Role><SAP Kinase-1><SAPK/JNK><SAPK1 Mitogen-Activated Protein Kinase><SAPK1/JNK><Sterility><Stress-Activated Protein Kinase JNK1><Stress-Activated Protein Kinase gamma><Subfamily Ethanol-Inducible Cytochrome P450><Subfamily IIE Cytochrome P450><Susceptibility><System><Techniques><Testing><Therapeutic><Time><Toxic effect on liver cells><Traction><Transphosphorylases><Transplantation><Vascular blood supply><Waiting Lists><acetaminophen hepatotoxicity><acetaminophen poisoning><acetaminophen-induced liver injury><adiposity><advanced age><allograft rejection><attenuate><attenuates><blood supply><c-jun N-Terminal Kinase><case report><cell damage><cell injury><cellular damage><cold preservation><cold storage><compound repositioning><compound repurposing><corpulence><cost><cost effective><damage to cells><design><designing><determine efficacy><develop therapy><developmental><drug intervention><drug repositioning><drug repurposing><drug treatment><drug use><effectiveness testing><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><ethylene glycol><evaluate efficacy><examine efficacy><fomepizole><geriatric><graft function><hepatic body system><hepatic damage><hepatic disease><hepatic injury><hepatic ischemia><hepatic organ system><hepatic toxicity><hepatopathy><hepatoxicity><improved><in vivo><inhibitor><injuries><injury to cells><innovate><innovation><innovative><intervention development><jun-NH2-Terminal Kinase><liver damage><liver disorder><liver injury><liver ischemia><liver preservation><liver transplantation><methanol poisoning><mitochondrial dysfunction><mortality><natural hypothermia><necrocytosis><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutic uses for existing drugs><new therapeutics><new therapy><new use of drug><new uses for an approved drug><new uses for existing drugs><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><operation><operations><pathophysiology><pathway><patient oriented outcomes><pharmaceutical intervention><pharmacologic><pharmacological intervention><pharmacological repurposing><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><poisoned><pre-clinical study><preclinical study><prevent><preventing><reperfusion><repositioning approved drugs><repositioning existing drugs><repurpose approved drugs><repurpose approved medication><repurpose approved therapeutic><repurpose existing drugs><repurpose existing medication><repurpose existing medicine><repurpose existing therapeutics><repurpose existing therapies><repurpose medicine><repurposing><repurposing a drug><repurposing agent><repurposing candidates><repurposing established drugs><repurposing established medication><repurposing existing pharmacological agents><repurposing medication><repurposing of already existing drugs><repurposing pharmaceuticals><response><senior citizen><social role><sterile><stress-activated protein kinase 1><therapeutic evaluation><therapeutic repositioning><therapeutic repurposing><therapeutic testing><therapy development><transplant><treatment development><vascular supply><waitlist>
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Alana Teresa Brennan

BOSTON UNIVERSITY MEDICAL CAMPUS, BOSTON, MA

Exploratory lead · 16/100
Active award
$81,750
FY 2026

Project Title

Assessing the mediating role of kidney function and weight/BMI in the association between INSTI use and blood pressure changes and hypertension in PWH: a secondary analysis of the REPRIEVE study.

Grant Number:

5R03AI189203-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2024

End Date:

11/30/2026

Project Abstract

Project Summary Our R03 application critically evaluates cardiovascular risks associated with integrase strand transfer inhibitors (INSTIs), focusing on blood pressure and hypertension among people living with HIV. Utilizing data from the REPRIEVE (Randomized Trial to Prevent Vascular Events in HIV)...

Research Terms

<AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Follow-up><Address><Adherence><Adopted><Affect><Albuminuria><Anti-Hypertensive Agents><Anti-Hypertensive Drugs><Anti-Hypertensives><BMI><BMI percentile><BMI z-score><BP homeostasis><BP regulation><Bechuanaland><Blood Pressure><Blood Serum><Blood Vessels><Body mass index><Botswana><Brazil><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Clinical><Complex><Confounding Factors (Epidemiology)><Confounding Variables><Creatinine><Data><Data Set><Diastolic Pressure><Diastolic blood pressure><Drug Precursors><Drugs><Economic Income><Economical Income><Economics><Eligibility><Eligibility Determination><Enrollment><Ensure><Epidemiologic Confounding Factor><Epidemiologic Methodology><Epidemiologic Methods><Epidemiologic research methodology><Epidemiologic research methods><Epidemiological Methods><Epidemiological Techniques><Event><Geography><Grant><Guidelines><HIV><HIV individuals><HIV infected individuals><HIV infected persons><HIV intervention><HIV people><HIV positive individuals><HIV positive people><HIV therapeutic><HIV therapy><HIV treatment><HIV-1 intervention><HIV-1 therapeutic><HIV-1 therapy><HIV-1 treatment><Health><Health Care><Health Policy><Health system><Heart Vascular><Human Immunodeficiency Virus therapy><Human Immunodeficiency Virus treatment><Human Immunodeficiency Viruses><Hypertension><Hypotensive Agent><Hypotensive Drugs><Incidence><Income><Inflammatory><Integrase><International><Intervention><LAV-HTLV-III><Link><Lymphadenopathy-Associated Virus><Measurement><Measures><Mediating><Mediation><Mediator><Medication><Methodology><Methods><Methods Epidemiology><Methods in epidemiology><Modernization><NIH Office of AIDS Research><Negotiating><Negotiation><Nucleosides><Outcome><PLWH><PWH><Participant><Pathway interactions><Pharmaceutical Preparations><Physiologic><Physiological><Population><Population Heterogeneity><Position><Positioning Attribute><Pro-Drugs><Probability><Prodrugs><Prospective, cohort study><Proteinuria><Protocol Screening><Public Health><Quetelet index><Randomization trial><Randomized><Recommendation><Regimen><Renal function><Reporting><Research><Research Priority><Resistance><Reverse Transcriptase Inhibitors><Risk><Risk Factors><Role><Safety><Secure><Serum><South Africa><Techniques><Tenofovir><Thailand><Therapeutic><Time><United States><Update><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Viread><Virus-HIV><Weight><Weight Gain><Weight Increase><active followup><anti-hypertension><antiretroviral therapy><antiretroviral treatment><blood pressure elevation><blood pressure homeostasis><blood pressure regulation><body weight gain><body weight increase><cardiovascular effects><cardiovascular health><cardiovascular risk><cardiovascular risk factor><circulatory system><clinical practice><co-infection><co-morbid><co-morbidity><coinfection><comorbidity><comparative><data diversity><differences in health><disparity in health><diverse data><diverse populations><drug/agent><economic><elevated blood pressure><enroll><follow up><follow-up><followed up><followup><health care policy><health difference><health disparity><heterogeneous population><high blood pressure><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><incomes><increase in blood pressure><increased blood pressure><individuals infected with HIV><individuals with HIV><individuals with human immunodeficiency virus><inhibitor><innovate><innovation><innovative><insight><kidney function><low income country><novel><pathway><people infected with HIV><people infected with human immunodeficiency virus><people living with HIV><people with HIV><people with human immunodeficiency virus><pharmacologic><population diversity><prevent><preventing><randomisation><randomization><randomized trial><randomly assigned><regulate BP><regulate blood pressure><resistant><response><secondary analysis><social role><sound><treat HIV><treat Human Immunodeficiency Virus><treatment risk><vascular><weights><wt gain>
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Wei Zhang

AUBURN UNIVERSITY AT AUBURN, Auburn, AL

Exploratory lead · 16/100
Active award
$77,000
FY 2026

Project Title

Probing the Nexus: Unraveling Neuroinflammation's Link to Anhedonia

Grant Number:

7R03MH138838-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/13/2024

End Date:

10/31/2026

Project Abstract

Project Summary / Abstract Anhedonia, a multifaceted construct encompassing reduced pleasure, decreased motivation, and impaired reward learning 1, represents a clinically relevant symptom dimension observed across diverse psychiatric disorders 2–13. Linked to poor therapeutic responses, anhedonia ...

Research Terms

<21+ years old><Active Follow-up><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Age><Anhedonia><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Behavior><Blood Sample><Blood leukocyte><Blood specimen><Brain><Brain Nervous System><Brain region><C-reactive protein><CNS Nervous System><Causality><Cell Count><Cell Number><Central Nervous System><Corpus Striatum><Corpus striatum structure><DWI (diffusion weighted imaging)><DWI-MRI><Data><Data Set><Development><Diagnostic><Diffusion Basis Spectrum Imaging><Diffusion MRI><Diffusion Magnetic Resonance Imaging><Diffusion Spectrum Imaging><Diffusion Weighted MRI><Diffusion weighted imaging><Diffusion-weighted Magnetic Resonance Imaging><Dimensions><Disease><Disorder><Dorsal><Dysfunction><Economic Burden><Encephalon><Environmental Factor><Environmental Risk Factor><Etiology><Functional disorder><Future><HPGF><Hepatocyte-Stimulating Factor><Hybridoma Growth Factor><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Image><Imaging Procedures><Imaging Technics><Imaging Techniques><Impairment><Inflammation><Inflammatory><Interleukin-6><Intervention><Investigation><Learning><Leukocytes><Leukocytes Reticuloendothelial System><Link><Long-term prospective studies><MGI-2><Marrow leukocyte><Measures><Mediating><Mediation><Mental disorders><Mental health disorders><Motivation><Myeloid Differentiation-Inducing Protein><Negotiating><Negotiation><Neuraxis><Nucleus Accumbens><PET><PET Scan><PET imaging><PETSCAN><PETT><Patient Self-Report><Patients><Pattern><Peripheral><Phenotype><Physiopathology><Plasmacytoma Growth Factor><Position><Positioning Attribute><Positron Emission Tomography Medical Imaging><Positron Emission Tomography Scan><Positron-Emission Tomography><Prefrontal Cortex><Process><Proteins, specific or class, C-reactive><Psychiatric Disease><Psychiatric Disorder><Psychosocial Factor><Rad.-PET><Reporting><Rewards><Role><Sampling><Self-Report><Severities><Striate Body><Striatum><Structure><Symptoms><Testing><Time><Variant><Variation><White Blood Cells><White Cell><active followup><adulthood><age associated><age associated effects><age correlated><age dependent><age effect><age group><age linked><age related><age related effects><age specific><ages><aging effect><biobank><biorepository><care burden><causation><clinical relevance><clinical validation><clinically relevant><cognitive development><cohort><cross-sectional investigation><cross-sectional research><dMRI><developmental><diffusion tensor imaging><disease causation><environmental risk><follow up><follow-up><followed up><followup><imaging><imaging study><impact of age><inflammation marker><inflammatory marker><influence of age><innovate><innovation><innovative><insight><interferon beta 2><investigate cross-sectional><investigate longitudinal><juvenile><juvenile human><large scale data><large scale data sets><large scale datasets><later in life><later life><longitudinal investigation><longitudinal research><longitudinal, prospective study><mental illness><neural><neural inflammation><neural mechanism><neuroinflammation><neuroinflammatory><neuromechanism><non-invasive imaging><noninvasive imaging><novel><older adult><older adulthood><pathophysiology><pleasure><polygenetic risk scores><polygenic risk score><positron emission tomographic (PET) imaging><positron emission tomographic imaging><positron emitting tomography><psychiatric illness><psychological disorder><psychosocial variables><putamen><response to therapy><response to treatment><reward circuitry><reward processing><secondary analysis><secondary outcome><social role><stem><striatal><study cross-sectional><study longitudinal><survey cross-sectional><survey longitudinal><therapeutic response><therapy response><treatment response><treatment responsiveness><white blood cell><white blood corpuscle>
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Cara Theresia Pager

STATE UNIVERSITY OF NEW YORK AT ALBANY, ALBANY, NY

Exploratory lead · 16/100
Active award
$76,988
FY 2026

Project Title

Insights into infection of Ilheus virus in mammalian and mosquito cells

Grant Number:

5R03AI188527-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/15/2024

End Date:

10/31/2026

Project Abstract

SUMMARY Global health is perpetually challenged by emerging and reemerging infectious diseases. In recent times climate change and globalization has contributed to the rampant spread of mosquitos from tropical and subtropical climates into more moderate climates, and thus also the spread of one of t...

Research Terms

<(IFN) α><(IFN)-α><(IFN)α><3' Untranslated Regions><3'UTR><3,4-dihydroxycinnamic acid><A. albopictus><A549><Ae. Albopictus><Aedes><Aedes albopictus><Alferon><Americas><Animals><Anti-viral Agents><Antisense Agent><Antisense Oligonucleotides><Aves><Avian><Band Shift Mobility Assay><Bandshift Mobility Assay><Birds><Blood monocyte><Brain Inflammation><Brazil><Caffeic Acids><Cell Body><Cell Line><CellLine><Cells><Cessation of life><Climate><Conserved Sequence><Culex><Culex (Genus)><Culicidae><Cultured Cells><Cyclization><DNA Helicases><DNA Unwinding Proteins><DNA unwinding enzyme><Death><Development><Disease><Disorder><ELISA><Electrons><Electrophoretic Mobility Shift Assay><Emerging Communicable Diseases><Emerging Infectious Diseases><Encephalitis><Endoplasmic Reticulum><Enzyme-Linked Immunosorbent Assay><Ergastoplasm><Fibroblasts><Flavivirus><Flavivirus Infections><Funding Mechanisms><Future><Generations><Genes><Genome><Genomic Segment><Geography><Group B Arbovirus><Health><Hep G2><HepG2><HepG2 cell line><Hepatocarcinoma><Hepatocellular Carcinoma><Hepatocellular cancer><Hepatoma><Human><IFN><IFN Alpha><IFN α><IFN-α><IFNa><IFNα><Immunoblotting><In Situ Hybridization><Infection><Innate Immune Response><Interferon Alfa-n3><Interferon-α><Interferons><Kidney><Kidney Urinary System><Kinetics><Knowledge><Leukocyte Interferon><Licensing><Liver Cells Carcinoma><Lung Adenocarcinoma><Lymphoblast Interferon><Lymphoblastoid Interferon><Marrow monocyte><Mediating><Membrane><Meteorological Climate><Methods><Mobility Shift Assay><Modern Man><Molecular><Molecular Virology><Monkeys><Mosquitoes><Negative Beta Particle><Negatrons><Non-Polyadenylated RNA><Orthoflavivirus><Parents><Pathogenesis><Plaque Assay><Population><Primary carcinoma of the liver cells><Proteins><Public Health><Publishing><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><R-Series Research Projects><R01 Mechanism><R01 Program><RNA><RNA Gene Products><RNA Sequences><RNA Stability><RT-PCR><Reagent><Replication Unit><Replicon><Reporter><Reporting><Research><Research Design><Research Grants><Research Project Grants><Research Projects><Reverse Transcriptase Polymerase Chain Reaction><Ribonucleic Acid><Role><SEQ-AN><Sequence Analyses><Sequence Analysis><Serology><Serology test><Skin><Strains Cell Lines><Structure><Study Type><Symptoms><Translations><Transmission><Vaccines><Vertebrate Animals><Vertebrates><Viral><Viral Diseases><Viral Genome><Virus><Virus Diseases><Virus Replication><Western Blotting><Western Immunoblotting><anti-viral compound><anti-viral drugs><anti-viral medication><anti-viral therapeutic><anti-virals><antisense oligo><burden of disease><burden of illness><cell type><climate change><climate region><climate zone><climatic><climatic changes><cross immunity><cross protection><cultured cell line><developmental><disease burden><effective therapy><effective treatment><enzyme linked immunoassay><epidemiology research study><epidemiology study><epidemiology survey><gel shift assay><genome segment><genomic region><global climate change><global health><helicase><human disease><in situ Hybridization Genetics><in situ Hybridization Staining Method><insight><liver carcinoma><membrane structure><monocyte><mosquito-borne><mosquitoborne><mutant><nano-luciferase><nanoluciferase><parent><plasmid DNA><programs><protein blotting><protein structure><protein structures><proteins structure><qRTPCR><renal><response><reverse transcriptase PCR><serology assay><social role><study design><tissue tropism><tool><translation><transmission process><treatment strategy><vector competence><vectorial competence><vertebrata><viral RNA><viral infection><viral multiplication><viral replication><virus RNA><virus genome><virus host interaction><virus infection><virus multiplication><virus-induced disease>
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Sabina Nduaguba

WEST VIRGINIA UNIVERSITY, MORGANTOWN, WV

Exploratory lead · 16/100
Active award
$76,000
FY 2026

Project Title

Feasibility and Adaptation of an Evidence-Based Multilevel Intervention for Improving Timeliness of Lung Cancer Treatment

Grant Number:

5R03CA297362-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2025

End Date:

1/31/2027

Project Abstract

Project Summary/Abstract Delayed time to treatment is a key determinant of poor survival among patients with lung cancer. Factors that affect timeliness of lung cancer treatment are multilevel in nature. However, most interventions target only one level of influence. Existing evidence-based interven...

Research Terms

<Accounting><Address><Adopted><Adoption><Affect><Attitude><Cancer Center><Cancer Treatment><Cancers><Caring><Climate><Clinical Research><Clinical Study><Clinical Trials><Credentialing><Data Collection><Death Rate><Diagnosis><Economic Income><Economical Income><Effectiveness><Ensure><Equilibrium><Evidence based intervention><Evidence based practice><Feasibility Studies><Goals><Health><Health Disparities Research><Health Policy><Health disparities related research><Health system><Income><Individual><Intervention><Intervention Strategies><Intervention Studies><Interview><Leadership><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Maryland><Measures><Medicine><Meteorological Climate><Methodology><Methods><NCI Organization><National Cancer Institute><Nature><Oncology><Oncology Cancer><Outcome><Patient Care><Patient Care Delivery><Patients><Pennsylvania><Perception><Provider><Public Health><Pulmonary Cancer><Pulmonary malignant Neoplasm><Research><Research Methodology><Research Methods><Risk><Science Policy><Site><Survey Instrument><Surveys><Target Populations><Thoracic Oncology><Time><Training><US State><Universities><Veterans><Veterans Health Administration><Veterans Health Affairs><West Virginia><Work><anti-cancer therapy><balance><balance function><barrier to care><barrier to health care><barrier to treatment><cancer care><cancer diagnosis><cancer therapy><cancer-directed therapy><care coordination><care delivery><care for patients><care of patients><caring for patients><climatic><coordinating care><design><designing><effective intervention><evidence base><health care policy><health disparities science><implementation science><improved><incomes><innovate><innovation><innovative><institutional climate><intervention research><interventional research><interventional study><interventions research><lung cancer><malignancy><mortality rate><neoplasm/cancer><obstacle to care><obstacle to health care><organizational climate><pilot trial><programs><provider barriers><provider-level barriers><research and methods><success><tool>
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Christophe G. Lambert

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Exploratory lead · 10/100
Solid budget
$300,000
FY 2024

Project Title

Illuminating the Druggable Genome Data Coordinating Center - Engagement Plan with the CFDE

Grant Number:

3OT2OD030546-01S4

Activity Code:

OT2

Mechanism:

Other

Agency:

NIH

Start Date:

9/23/2020

End Date:

9/22/2025

Project Abstract

The Illuminating the Druggable Genome (IDG) consortium has two major goals: First, consolidate disparate protein- and disease-centric data types from multiple sources, integrate and harmonize them, then make them readily available to the public; Second, adapt and scale existing technologies to unvei...

Research Terms

<ATP-protein phosphotransferase><Area><Biological><Chemicals><Clinical><Communities><Complex><Darkness><Data><Data Bases><Data Coordinating Center><Data Coordination Center><Data Set><Databases><Disease><Disorder><Disparate><Ensure><FAIR data><FAIR guiding principles><FAIR principles><Family><Feedback><Findable, Accessible, Interoperable and Re-usable><Findable, Accessible, Interoperable, and Reusable><Funding><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><GTEx><Gene variant><Generations><Genes><Genetic Alteration><Genetic Change><Genetic defect><Genome><Genotype><Genotype-Tissue Expression Project><Goals><Investments><Ion Channel><Ionic Channels><Kinase Family Gene><Knowledge Management Center><Manuals><Membrane Channels><Mutation><Pathology><Pathway interactions><Phenotype><Protein Kinase><Proteins><Proteome><Research Resources><Resources><Risk><Source><Structure><Technology><Update><allele variant><allelic variant><biologic><data base><data integration><data management and coordinating center><data management center><depository><design><designing><differential expression><differentially expressed><gene function><genetic variant><genome mutation><genome resource><genomic data resource><genomic resource><genomic sequencing resource><genomic variant><glycogen synthase a kinase><human disease><hydroxyalkyl protein kinase><improved><knowledgebase><member><multiple data types><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><phosphorylase b kinase kinase><programs><repository><transcriptional differences>
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Jeremy Joseph Yang

UNIVERSITY OF NEW MEXICO HEALTH SCIS CTR, ALBUQUERQUE, NM

Exploratory lead · 10/100
Solid budget
$300,000
FY 2024

Project Title

Illuminating the Druggable Genome Data Coordinating Center - Engagement Plan with the CFDE

Grant Number:

3OT2OD030546-01S4

Activity Code:

OT2

Mechanism:

Other

Agency:

NIH

Start Date:

9/23/2020

End Date:

9/22/2025

Project Abstract

The Illuminating the Druggable Genome (IDG) consortium has two major goals: First, consolidate disparate protein- and disease-centric data types from multiple sources, integrate and harmonize them, then make them readily available to the public; Second, adapt and scale existing technologies to unvei...

Research Terms

<ATP-protein phosphotransferase><Area><Biological><Chemicals><Clinical><Communities><Complex><Darkness><Data><Data Bases><Data Coordinating Center><Data Coordination Center><Data Set><Databases><Disease><Disorder><Disparate><Ensure><FAIR data><FAIR guiding principles><FAIR principles><Family><Feedback><Findable, Accessible, Interoperable and Re-usable><Findable, Accessible, Interoperable, and Reusable><Funding><G Protein-Complex Receptor><G Protein-Coupled Receptor Genes><G-Protein-Coupled Receptors><GPCR><GTEx><Gene variant><Generations><Genes><Genetic Alteration><Genetic Change><Genetic defect><Genome><Genotype><Genotype-Tissue Expression Project><Goals><Investments><Ion Channel><Ionic Channels><Kinase Family Gene><Knowledge Management Center><Manuals><Membrane Channels><Mutation><Pathology><Pathway interactions><Phenotype><Protein Kinase><Proteins><Proteome><Research Resources><Resources><Risk><Source><Structure><Technology><Update><allele variant><allelic variant><biologic><data base><data integration><data management and coordinating center><data management center><depository><design><designing><differential expression><differentially expressed><gene function><genetic variant><genome mutation><genome resource><genomic data resource><genomic resource><genomic sequencing resource><genomic variant><glycogen synthase a kinase><human disease><hydroxyalkyl protein kinase><improved><knowledgebase><member><multiple data types><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><novel drug target><novel druggable target><novel pharmacotherapy target><novel therapeutic target><novel therapy target><pathway><phosphorylase b kinase kinase><programs><repository><transcriptional differences>
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Xiao-Fei Kong

UT SOUTHWESTERN MEDICAL CENTER, DALLAS, TX

Exploratory lead · 10/100
Active award
$249,000
FY 2025

Project Title

Novel approaches to dissect the genetic susceptibilities to celiac disease

Grant Number:

1R03DK144282-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/9/2025

End Date:

8/31/2027

Project Abstract

Abstract Celiac disease (CeD) affects approximately 1% of the U.S. population. It is associated with several co- morbidities, including osteoporosis, type 1 diabetes (T1DM), anemia, reduced quality of life, and increased cancer risk. Currently, there is no approved drug to treat CeD, and the primary...

Research Terms

<(IFN) α><(IFN)-α><(IFN)α><Adherence><Affect><African><African ancestry><African descent><Age><Alferon><All of Us Program><All of Us Research Program><All of Us Research Project><Alleles><Allelomorphs><American><Anemia><AoURP><Autoimmune Diseases><Blood><Blood Reticuloendothelial System><Brittle Diabetes Mellitus><Celiac Disease><Celiac Sprue><Clinical><Cloud Computing><Cloud Infrastructure><Code><Coding System><Coeliac Disease><Computing Methodologies><Cross-Product Ratio><Data><Data Set><Development><Diarrhea><Diathesis><Disease><Disease susceptibility><Disorder><Drugs><Ethnic Origin><Ethnicity><European ancestry><Evolution><Family><Frequencies><Future><GWA study><GWAS><Gene Frequency><Genes><Genetic><Genetic Annotation><Genetic Diseases><Genetic Heterogeneity><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Risk><Genetic Susceptibility><Genetic predisposing factor><Genetic propensity><Genetic study><Genome><Glutelin><Gluten><Gluten Enteropathy><Gluten-Sensitive Enteropathy><Gluten-free diet><Goals><Grant><Guidelines><HLA testing><HLA typing><HLA-DQ2><HLA-DQB1><HLA-DQB1 antigen><HLA-DQbeta1><Haplotypes><High Prevalence><Human><Human Genetics><IDDM><IFN><IFN Alpha><IFN α><IFN-α><IFNa><IFNα><IL21><Incidence><Individual><Ingestion><Inherited Predisposition><Inherited Susceptibility><Insulin-Dependent Diabetes Mellitus><Interferon Alfa-n3><Interferon-α><Interferons><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Leukocyte Interferon><Linkage Disequilibrium><Lymphoblast Interferon><Lymphoblastoid Interferon><Machine Learning><Medication><Mental Depression><Migraine><Migraine Headache><Minor><Minority><Missense Mutation><Modern Man><NGS Method><NGS system><Network Analysis><Non-tropical Sprue><Nontropical Sprue><Odds Ratio><Osteoporosis><Pathogenesis><Pathway Analysis><Pathway interactions><Patients><Penetrance><Pharmaceutical Preparations><Phosphorylation><Play><Population><Population Heterogeneity><Protein Phosphorylation><Proteins><QOL><Quality of life><Relative Odds><Research><Risk><Risk Ratio><Risk-associated variant><Role><STAT1><STAT1 gene><STAT3><STAT3 gene><STAT91><Sample Size><Sudden-Onset Diabetes Mellitus><Symptoms><T1 DM><T1 diabetes><T1D><T1DM><Technology><Testing><Therapeutic><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Upregulation><Variant><Variation><actionable mutation><actionable variants><ages><allelic frequency><autoimmune condition><autoimmune disorder><autoimmunity disease><cancer risk><case control><case-controlled><clinical heterogeneity><clinically actionable><cloud based computing><cloud computer><co-morbid><co-morbidity><cohort><comorbidity><computational methodology><computational methods><computer based method><computer methods><computing method><depression><developmental><disease risk><disorder risk><diverse populations><drug/agent><entire genome><ethnic diversity><ethnically diverse><exome><exome sequencing><exome-seq><experience><full genome><gene-based diagnostics><genetic condition><genetic diagnosis><genetic diagnostics><genetic disorder><genetic disorder diagnosis><genetic etiology><genetic mechanism of disease><genetic risk factor><genetic vulnerability><genetic-focused diagnostic><genetically predisposed><genome sequencing><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic data><genomic dataset><heterogeneous population><high risk><human leukocyte antigen testing><human leukocyte antigen typing><idiopathic steatorrhea><improved><ingest><inherited factor><innovate><innovation><innovative><insight><insulin dependent diabetes><insulin dependent type 1><interleukin-21><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><liability to disease><loss of function><low-frequency mutation><machine based learning><missense single nucleotide polymorphism><missense single nucleotide variant><missense variant><new approaches><next gen sequencing><next generation sequencing><nextgen sequencing><novel><novel approaches><novel strategies><novel strategy><participant enrollment><pathway><patient enrollment><phenotypic data><population diversity><rare allele><rare mutation><rare variant><recruit><risk allele><risk gene><risk genotype><risk loci><risk locus><risk stratification><risk variant><sex><social role><stratify risk><therapeutic target><type I diabetes><type one diabetes><whole genome><whole genome association analysis><whole genome association study>
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Samantha D Minc

DUKE UNIVERSITY, DURHAM, NC

Exploratory lead · 10/100
Active award
$242,250
FY 2025

Project Title

Understanding Diabetes and Peripheral Artery Disease-Related Amputation Disparities in North Carolina

Grant Number:

1R03DK144348-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/12/2025

End Date:

7/31/2027

Project Abstract

Amputation is a devastating but preventable complication of diabetes (DM) and peripheral artery disease (PAD); it serves as a marker for severe cardiovascular disease and for gaps in quality of care. Although amputation risk is highest in communities with higher levels of traditional risk factors, s...

Research Terms

<Affect><Amputation><Area><Bayesian Analysis><Bayesian computation><Bayesian inference><Bayesian network analysis><Bayesian spatial analysis><Bayesian statistical analysis><Bayesian statistical inference><Bayesian statistics><Blood Vessels><Cardiovascular Diseases><Care Givers><Caregivers><Chronic><Communities><Complications of Diabetes Mellitus><Country><Coupled><Data><Data Bases><Data Set><Databases><Diabetes Complications><Diabetes Mellitus><Diabetes-Related Complications><Diabetic Complications><Disease><Disorder><Disparities><Disparity><ED visit><ER visit><Economics><Effectiveness of Interventions><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><Environmental Factor><Environmental Risk Factor><Epidemiologic Research><Epidemiologic Studies><Epidemiological Studies><Epidemiology Research><Ethnic Origin><Ethnicity><Extremities><Focus Groups><Funding><Future><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Geography><Goals><Health><Health Care Costs><Health Care Providers><Health Costs><Health Inequity><Health Personnel><Hospital Admission><Hospitalization><Hot Spot><Housing><Inequalities in Health><Inequities in Health><Infection><Inpatients><Intervention><Intervention Studies><K23 Award><K23 Mechanism><K23 Program><Limb structure><Limbs><Location><Maps><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentors><Methodology><Methods><Modernization><Non-Trunk><North Carolina><Patients><Peripheral arterial disease><Persons><Population><Population Study><Position><Positioning Attribute><Preventative intervention><Process><Provider><QOC><Qualitative Methods><Qualitative Research><Quality of Care><Quasi-experiment><Quasi-experimental analysis><Quasi-experimental approach><Quasi-experimental design><Quasi-experimental methods><Quasi-experimental research><Quasi-experimental study><Quasi-experimental technique><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Reproducibility><Research><Research Grants><Research Methodology><Research Methods><Research Project Grants><Research Projects><Resolution><Rest><Risk><Risk Factors><Rural><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Surgeon><Tobacco Consumption><Tobacco use><Translating><Translations><Transportation><Ulcer><Ulceration><United States><Universities><West Virginia><Work><acceptability and feasibility><access to health care><accessibility of health care><accessibility to health care><cardiovascular disorder><care utilization><community engaged intervention><community engaged participatory research><community engaged research><community engagement><community informed intervention><community marginalization><community partnered research><community partners><community-based partners><community-engaged study><community-partnered intervention><community-partnered study><data base><diabetes><disparity in health><economic><effectiveness study><engagement with communities><environmental risk><epidemiologic investigation><epidemiology study><experience><food security><foot><geographic site><health care access><health care availability><health care personnel><health care quality><health care service access><health care service availability><health care worker><health disparity><health inequalities><health provider><health workforce><high risk><implementation science><inferential statistics><intervention for prevention><intervention research><interventional research><interventional study><interventions research><marginalized community><medical personnel><patient population><peripheral artery disease><population-based study><population-level study><preservation><prevention intervention><preventional intervention strategy><preventive intervention><qualitative reasoning><racial><racial background><racial origin><recruit><research and methods><resolutions><risk mitigation><rural area><rural health disparities><rural location><rural region><social><spatial epidemiology><statistical analysis><stressor><studies of populations><study of the population><tissue wound><tobacco product use><translation><treatment provider><urban health disparities><vascular><wound><wounding><wounds>
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Senthil Selvaraj

DUKE UNIVERSITY, DURHAM, NC

Exploratory lead · 10/100
Active award
$242,250
FY 2025

Project Title

Probing Regional Metabolism During Exercise through Coronary Sinus Sampling

Grant Number:

1R03HL180898-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Despite advances in our management of patients with heart failure with reduced ejection fraction (HFrEF), substantial residual morbidity and mortality continues to plague the contemporary treatment era. A hallmark feature of HF remains reduced exercise capacity, which is ass...

Research Terms

<Achievement><Achievement Attainment><Aldosterone><Angiotensin-Forming Enzyme><Angiotensinogenase><Angiotensins><Armpit><Arteries><Assay><Atrial><Axilla><Axillary><Beds><Bioassay><Bioenergetics><Biological Assay><Biology><Blood><Blood Reticuloendothelial System><Blood Sample><Blood specimen><Carbohydrates><Cardiac><Cardiac Atrium><Cardiac Catheterization><Cardiac Catheterization Procedures><Cardiology><Cardiovascular><Cardiovascular Body System><Cardiovascular Organ System><Cardiovascular system><Catheters><Cessation of life><Chronic><Clinical><Co-Transporters><Collaborations><Consumption><Coronary sinus structure><Coupled><D-Glucose><Data><Death><Dextrose><Disease><Disorder><Distant><Dobutamine><Dose><Drugs><Dysfunction><Early-Stage Clinical Trials><Electrophysiology><Electrophysiology (science)><Equipment><Esters><Evaluation><Exercise><Exercise Tolerance><Fasting><Fats><Fatty Acid Metabolism Pathway><Fatty Acids><Fatty acid glycerol esters><Feasibility Studies><Femoral vein><Femur><Free Fatty Acids><Functional disorder><Funding><Future><Glucose><Goals><Heart><Heart Atrium><Heart Catheterization><Heart Catheterization Procedure><Heart Vascular><Heart failure><Impairment><Insertion of catheter into heart chamber><Intermediary Metabolism><Internal Jugular Vein><Internal jugular vein structure><Intervention><Investigators><Ketone Bodies><Ketones><Ketosis><Laboratories><Leg><Lower Extremity><Lower Limb><Maintenance><Measures><Medication><Membrum inferius><Metabolic><Metabolic Processes><Metabolism><Methodology><Mitochondria><Modernization><Morbidity><Morbidity - disease rate><Muscle><Muscle Tissue><Myocardial><NHLBI><Na element><National Heart, Lung, and Blood Institute><Natriuretic Peptide Hormones><Natriuretic Peptides><Neurophysiology / Electrophysiology><Nonesterified Fatty Acids><O element><O2 element><Outcome><Oxygen><Participant><Pathologic><Pathway interactions><Patients><Peripheral><Pharmaceutical Preparations><Phase 1 Clinical Trials><Phase I Clinical Trials><Phenotype><Physiologic><Physiological><Physiopathology><Pilot Projects><Placebos><Position><Positioning Attribute><Procedures><Prospective Studies><Proteomics><QOL><Quality of life><Recovery><Renin><Research><Research Personnel><Researchers><Residual><Residual state><Rest><Risk><Role><Safety><Sampling><Sham Treatment><Skeletal Muscle><Sodium><Source><Stress><Sympathetic Nervous System><System><Techniques><Therapeutic><Time><Tracer><Underarm><Universities><University Hospitals><Venous><Voluntary Muscle><blood pump><cardiac failure><cardiac function><cardiometabolic><cardiometabolism><career><circulatory system><coronary sinus><death risk><diagnostic catheterization><dietary><drug/agent><electrophysiological><exercise capacity><exercise intensity><exercise intolerance><fasted><fasts><fatty acid metabolism><function of the heart><heart failure and reduced ejection fraction><heart failure with reduced ejection fraction><heart function><hemodynamics><improved><inhibitor><ketogenic><ketogentic><mitochondrial><mortality><mortality risk><muscular><oxidation><pathophysiology><pathway><phase 2 trial><phase I protocol><phase II trial><pilot study><pressure><professor><sham therapy><social role><stable isotope><sugar><symporter><uptake>
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Phillip A Doerfler

VERSITI BLOOD HEALTH, INC., MILWAUKEE, WI

Exploratory lead · 10/100
Active award
$242,048
FY 2025

Project Title

DNA damage responses to genome editing in hematopoietic stem cells

Grant Number:

1R03DK142988-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/8/2025

End Date:

8/31/2027

Project Abstract

Project Summary Several genome editing strategies have been developed for the treatment of genetic diseases that affect the hematopoietic system, such as sickle cell disease and beta-thalassemia. Although there has been extensive research on detecting off-target effects of genome editors, there is l...

Research Terms

<5q Deletion><5q-><7q deletion syndrome><7q- syndrome><Aberrant Chromosome><Activities of Daily Living><Activities of everyday life><Address><Adverse Experience><Adverse event><Affect><Aneuploid><Aneuploidy><Antioncogene Protein p53><Apoptosis><Apoptosis Pathway><Apoptotic><Area><Attenuated><Award><B-thalassemia><Blood Diseases><Blood Precursor Cell><Bone Marrow><Bone Marrow Reticuloendothelial System><Cancer Cause><Cancer Etiology><Cancers><Caspase><Caspase Gene><Cell Body><Cell Cycle><Cell Cycle Arrest><Cell Division Cycle><Cell Growth in Number><Cell Isolation><Cell Multiplication><Cell Proliferation><Cell Segregation><Cell Separation><Cell Separation Technology><Cell division><Cell-Death Protease><Cells><Cellular Assay><Cellular Proliferation><Cellular Tumor Antigen P53><Centromere><Chromosomal Aberrations><Chromosomal Abnormalities><Chromosomal Alterations><Chromosomal Rearrangement><Chromosome Aberrations><Chromosome Alterations><Chromosome Anomalies><Chromosome Arm><Chromosome Segregation><Chromosome abnormality><Chromosomes><Clinical><Clonal expansion of hematopoietic cells><Clonal expansion of hematopoietic stem cells><Clonal hematopoietic expansion><Cysteine Endopeptidases><Cysteine Protease><Cysteine Proteinases><Cytogenetic Aberrations><Cytogenetic Abnormalities><DNA Damage><DNA Damage Repair><DNA Double Strand Break><DNA Injury><DNA Rearrangement><DNA Repair><DNA Repair Pathway><DNA Sequence Rearrangement><DNA Therapy><DNA editor><Data><Diagnosis><Disease><Disorder><Dysmyelopoietic Syndromes><Eligibility><Eligibility Determination><Event><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Frequencies><Future><Gene Rearrangement><Gene Transfer Clinical><Genes><Genetic><Genetic Diseases><Genetic Intervention><Genetic Materials><Genetics-Mutagenesis><Genome><Genome Instability><Genome Stability><Genomic Instability><Genomic Stability><Genomics><Hb SS disease><HbSS disease><Hematologic Body System><Hematologic Diseases><Hematologic Organ System><Hematological Disease><Hematological Disorder><Hematopoiesis><Hematopoietic Body System><Hematopoietic Cellular Control Mechanisms><Hematopoietic Progenitor Cells><Hematopoietic System><Hematopoietic stem cells><Hemoglobin S Disease><Hemoglobin sickle cell disease><Hemoglobin sickle cell disorder><Hemoglobinopathies><Heritability><Heterograft><Heterologous Transplantation><Human><ICE-like protease><In Vitro><Individual><Investigators><K01 Award><K01 Mechanism><K01 Program><Knock-out><Knockout><Lead><Lesion><M Phase><Maintenance><Malignant><Malignant - descriptor><Malignant Neoplasms><Malignant Tumor><Mediating><Mediator><Mendelian disease><Mendelian disorder><Mendelian genetic disorder><Mentored Research Scientist Development Award><Mentored Training Award><Methods><Mitosis><Mitosis Stage><Modern Man><Molecular><Mutagenesis><Mutagenesis Molecular Biology><Myelodysplastic Disease><Myelodysplastic Syndromes><Nature><Oncoprotein p53><Orphan Disease><P53><Pathologic><Pathway interactions><Patients><Pb element><Phosphoprotein P53><Phosphoprotein pp53><Process><Progenitor Cells><Programmed Cell Death><Protein TP53><Protocol Screening><QOL><Quality of life><Rare Diseases><Rare Disorder><Refractory Anemia with an Excess of Blasts><Refractory anaemia with excess blasts><Research><Research Personnel><Research Scientist Development Award><Research Support><Researchers><Safety><Sickle Cell Anemia><Smoldering Leukemia><Somatic Mutation><TP53><TP53 gene><TRP53><Testing><Therapeutic><Therapeutic Gene Editing><Tumor Protein p53><Tumor Protein p53 Gene><Unscheduled DNA Synthesis><WHIM syndrome><Warts, Hypogammaglobulinemia, Infections, and Myelokathexis syndrome><Xenograft><Xenograft procedure><Xenotransplantation><attenuate><attenuates><beta Thalassemia><blood cell formation><blood cell progenitor><blood disorder><blood progenitor><blood stem cell><blood-forming stem cell><cell assay><cell sorting><cell type><chromosomal defect><chromosome 5q loss><chromosome 7q deletion syndrome><chromosome defect><chromosome division><chromothripsis><clonal expansions in the blood><clonal hematopoiesis><clones in hematopoietic cells><cystein protease><cystein proteinase><cysteine endopeptidase><daily living function><daily living functionality><daughter cell><del(5q)><del(7q) syndrome><entire genome><flow cytophotometry><full genome><functional ability><functional capacity><gene editor><gene repair therapy><gene therapy><gene-based therapy><gene-editing therapy><genetic condition><genetic disorder><genetic therapy><genome editing><genome editing based therapy><genome editing therapy><genome editing treatment><genome editing-based therapeutics><genome editor><genome integrity><genome sequencing><genomic editing><genomic integrity><genomic rearrangement><genomic therapy><genotoxicity><heavy metal Pb><heavy metal lead><hematopoietic cell clones><hematopoietic progenitor><hematopoietic stem cell clonality><hematopoietic stem progenitor cell><hemopoietic progenitor><hemopoietic stem cell><improved><in vivo><knock-down><knockdown><malignancy><micronucleus><monogenic disease><monogenic disorder><monosomy 7q><myelodysplasia><neoplasm/cancer><nuclease><orphan disorder><p-Thalassemia><p53 Antigen><p53 Genes><p53 Tumor Suppressor><partial monosomy 7q syndrome><pathway><pharmacologic><precancer><precancerous><premalignant><preservation><prevent><preventing><progenitor cell function><progenitor cell regeneration><progenitor cell self renewal><progenitor function><progenitor regeneration><progenitor self renewal><protein p53><repair><repaired><response><self-renew><self-renewal><sickle cell disease><sickle cell disorder><sickle disease><sicklemia><single-gene disease><single-gene disorder><somatic variant><stem and progenitor cell function><stem and progenitor cell regeneration><stem and progenitor cell self renewal><stem and progenitor function><stem cell function><stem cell regeneration><stem cell self renewal><stem cells><telomere><therapeutic editing><therapeutic genome editing><whole genome><xeno-transplant><xeno-transplantation><β-thalassemia>
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Gabriella Mcloughlin

TEMPLE UNIV OF THE COMMONWEALTH, PHILADELPHIA, PA

Exploratory lead · 10/100
Active award
$237,750
FY 2025

Project Title

Investigating Student-Level Outcomes of Equity-Focused Implementation Mapping in a Cluster Randomized Trial to enhance the impact of Universal School Meals

Grant Number:

1R03HL178872-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2027

Project Abstract

PROJECT ABSTRACT The overall goal of this R03 award is to provide Gabriella McLoughlin, PhD, MS, with funding to investigate the impact of an equity-focused implementation strategy on participation and uptake of Universal School Meals (USM) among the students most at risk for food insecurity and obe...

Research Terms

<0-11 years old><21+ years old><Academic achievement><Address><Adolescent><Adolescent Youth><Adoption><Adult><Adult Human><Aggregated Data><Award><BMI><BMI percentile><BMI z-score><Body mass index><Caloric Intake><Categories><Child><Child Youth><Childhood><Children (0-21)><Clinical Research><Clinical Study><Cluster randomization trial><Cluster randomized trial><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Consumption><Data><Data Aggregation><Data Set><Dietary intake><Dietary quality><Disease><Disorder><Doctor of Philosophy><Economic Income><Economical Income><Effectiveness><Energy Intake><Equity><Ethnic Origin><Ethnicity><Evaluation><Evidence based intervention><Expenditure><Face><Food><Food Safety><Foundations><Funding><Goals><Grant><Groups at risk><Health><Health Benefit><Hybrids><Income><Inequity><Intervention><Interview><Investigation><K01 Award><K01 Mechanism><K01 Program><Link><Low income><Maps><Measurement><Mentored Research Scientist Development Award><Mentored Training Award><Methods><Modeling><NHLBI><National Heart, Lung, and Blood Institute><Nutrient><Nutrition><Obesity><Outcome><Parents><Participant><People at risk><Perception><Performance><Persons at risk><Ph.D.><PhD><Philadelphia><Policies><Populations at Risk><Position><Positioning Attribute><Public Health><Qualitative Methods><Quetelet index><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Randomization trial><Randomized><Reporting><Research><Research Grants><Research Project Grants><Research Projects><Research Scientist Development Award><Risk><Running><School-Age Population><Schools><Structure><Students><Test Result><Testing><Time><United States><Work><Youth><Youth 10-21><adiposity><adulthood><barriers to implementation><caloric dietary content><compare intervention><comparison intervention><corpulence><cost><diet quality><effectiveness and implementation trial><effectiveness trial><effectiveness/implementation hybrid trial><effectiveness/implementation trial><ethnic minority><evidence base><faces><facial><food insecurity><food security><health equity><high risk><high school><implementation barriers><implementation challenges><implementation research><implementation science><implementation strategy><implementation trial><improved><incomes><indexing><innovate><innovation><innovative><juvenile><juvenile human><kids><marginalization><marginalized group><marginalized individual><marginalized people><marginalized population><meal at school><multiple data sources><novel><obesity risk><parent><pediatric><pilot trial><primary outcome><programs><qualitative reasoning><racial><racial background><racial minority><racial origin><randomisation><randomization><randomized trial><randomly assigned><risk for obesity><risk of obesity><safety net><school age><school breakfast><school district><school lunch><school meal><social><social health determinants><social stigma><stigma><strategies for implementation><student engagement><student meal><student motivation><student participation><uptake><youngster><youth age>
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Adam Steven Wilk

INDIANA UNIVERSITY INDIANAPOLIS, INDIANAPOLIS, IN

Exploratory lead · 10/100
Active award
$237,750
FY 2025

Project Title

Medicare's Kidney Care Choices Models: Participation and Nephrology Care Practice Reforms

Grant Number:

1R03DK140424-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2025

End Date:

8/31/2027

Project Abstract

Medicare is the dominant payer for the >800,000 US patients with end-stage kidney disease (ESKD). These patients have poor outcomes and high medical spending, and there is wide variation in the quality and value of care across communities. Medicare is increasingly using novel payment models to conta...

Research Terms

<21+ years old><Adult><Adult Human><Affect><Award><Behavior><Caring><Cessation of life><Chronic Disease><Chronic Illness><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Communities><Consolidated Framework for Implementation Research><Consolidated Framework for Implementation Science><Consolidated Framework for Implementing Change><Data><Data Set><Death><Dialysis><Dialysis procedure><ESKD><ESRD><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Expenditure><Fostering><Funding><Future><Gatekeeping><Geography><Goals><Health><Health Care><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Household><Improve Access><Incentives><Individual><Interview><Investigation><Jobs><K01 Award><K01 Mechanism><K01 Program><Kidney><Kidney Diseases><Kidney Failure><Kidney Insufficiency><Kidney Urinary System><Knowledge><Learning><Link><Low income><Medical><Medical Care Costs><Medicare><Mentored Research Scientist Development Award><Mentored Training Award><Modeling><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Nephrology><Nephropathy><Occupations><Outcome><Participant><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Performance><Physician's Role><Physicians><Policies><Population><Prevention><Professional Positions><Provider><QOC><Qualitative Methods><Quality of Care><Renal Disease><Renal Failure><Renal Insufficiency><Replacement Therapy><Research><Research Design><Research Scientist Development Award><Risk><Role><Sampling><Savings><Services><Socio-economic status><Socioeconomic Status><Specialty><Structure><Study Type><System><Title 18><Training><Transplantation><Underserved Population><Update><Variant><Variation><adulthood><beneficiary><care costs><chronic disorder><chronic kidney disease><community factor><community-level factor><dialysis therapy><disease prevention><disorder prevention><experience><gatekeeper><health care service><health insurance for disabled><improved><innovate><innovation><innovative><kidney disorder><medical costs><medical expenses><medical specialties><mortality><novel><outreach><patient oriented outcomes><payment><premature><prematurity><qualitative reasoning><recruit><renal><renal disorder><social><social role><socio-economic position><socioeconomic position><study design><transplant><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people>
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Deshira Damilka Wallace

UNIV OF NORTH CAROLINA CHAPEL HILL, CHAPEL HILL, NC

Exploratory lead · 10/100
Active award
$229,245
FY 2025

Project Title

Measuring demographic variables across groups to understand cardiovascular health among US adults

Grant Number:

1R03HL180983-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2027

Project Abstract

Cardiovascular disease is not equally distributed across ethnic and racial groups. Studies have shown that between and within-group disparities exist due to differences in social and economic positioning and related experiences. However, one underexplored area in social positioning is examining disp...

Research Terms

<21+ years old><Address><Adolescent><Adolescent Youth><Adult><Adult Human><Affect><Americas><Area><Awareness><Behavioral><Biological><Cardiac Diseases><Cardiac Disorders><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Categories><Censuses><Characteristics><Classification><Clinical Research><Clinical Study><Communities><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><Data><Data Collection><Decrease health disparities><Demographic Survey><Disease><Disease Frequency Surveys><Disease Outcome><Disorder><Disparities><Disparity><Disparity population><Distress><Economics><Ethnic Group><Ethnic Origin><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity><Ethnicity People><Ethnicity Population><Exclusion><Exposure to><Food><Future><Goals><HCHS/SOL Study><HCHS/SOL cohort><Health><Health Disparities Research><Health Status><Health disparities related research><Health disparity mitigation><Health disparity reduction><Heart Diseases><Heart Vascular><Hispanic Community Health Study/Study of Latinos><Individual><Intervention><Investigators><Language><Latino Population><Latino group><Latino individual><Latino people><Latinos><Level of Health><Link><Literature><Longitudinal Studies><Lower health disparities><Measurement><Measures><Medical Research><Mental Health><Mental Hygiene><Methods><Mitigate health disparities><NHLBI><NIH><National Heart, Lung, and Blood Institute><National Institutes of Health><Outcome><Participant><Patient Self-Report><Personal Satisfaction><Personal awareness><Persons><Population><Position><Positioning Attribute><Process><Psychological Health><Public Health><Publishing><Puerto Rican><Race><Races><Racial Group><Reduce health disparities><Reporting><Research><Research Personnel><Researchers><Risk><Risk Factors><Self Perception><Self image><Self view><Self-Report><Smoking><Social Characteristics><Social status><Socialization><South American><Stress><Subgroup><Survey Instrument><Surveys><Systematics><Testing><United States><United States National Institutes of Health><Walking><Work><adulthood><biologic><cardiac disease risk><cardiac disorder risk><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cardiovascular health><cardiovascular risk><cardiovascular risk factor><circulatory system><cognitive interview><demographics><differences in health><disadvantaged group><disadvantaged individual><disadvantaged people><disadvantaged population><disadvantaged subgroup><disease disparity><disparities across groups><disparity across subgroups><disparity among groups><disparity among subgroups><disparity between groups><disparity between subgroups><disparity in health><economic><ethnic subgroup><ethnicity group><experience><group disparity><group inequality><group inequity><health difference><health disparities science><health disparity><health level><heart disease risk><heart disorder><heart disorder risk><implementation research><improved><inequalities among populations><inequalities between populations><inequalities in populations><inequality across populations><inequality among groups><inequality between groups><inequality in groups><inequities among populations><inequities between populations><inequities in populations><inequity across groups><inequity across populations><inequity between groups><inequity in groups><juvenile><juvenile human><long-term study><longitudinal outcome studies><multi-racial><multiracial><novel><physical conditioning><physical health><population inequality><population inequity><programs><psychosocial><racial><racial background><racial origin><racial population><racial subgroup><research study><self awareness><self knowledge><sex><social><social disadvantage><social disparities><social group><social inequality><social position><social space><social standing><socio-economic><socio-economically><socioeconomically><socioeconomics><subgroup disparity><theories><unequal group><unequal population><well-being><wellbeing>
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Gabriel S Tajeu

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 10/100
Active award
$222,750
FY 2025

Project Title

A Clinical Decision Support Questionnaire to Identify Barriers to Blood Pressure Control

Grant Number:

1R03HL176852-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/21/2025

End Date:

6/30/2027

Project Abstract

Hypertension, defined as systolic blood pressure (SBP) ≥ 130 mm Hg or diastolic BP (DBP) ≥ 80 mm Hg, is a leading cause of morbidity and mortality in the US and affects nearly half of US adults. Hypertension is also associated with substantial healthcare costs. In 2016, hypertension cost the US heal...

Research Terms

<21+ years old><Address><Adoption><Adult><Adult Human><Affect><Alabama><Anti-Hypertensive Agents><Anti-Hypertensive Drugs><Anti-Hypertensives><Applications Grants><BP control><BP management><BP reduction><Blood Pressure><Cardiovascular Diseases><Cities><Clinical><Clinical Data><Communities><Computerized Medical Record><Development><Diastolic Pressure><Diastolic blood pressure><Diet><Drugs><Electronic Medical Record><Event><Exercise><Face><Feedback><Focus Groups><Future><Goals><Grant Proposals><Health Care><Health Care Costs><Health Care Providers><Health Care Systems><Health Costs><Health Food><Health Personnel><Health system><Hypertension><Hypotensive Agent><Hypotensive Drugs><Intervention><Interview><Life Style><Lifestyle><Medication><Morbidity><Morbidity - disease rate><Nutritious food><Participant><Patients><Pharmaceutical Preparations><Population Control><Qualitative Methods><Questionnaires><Recommendation><Reporting><Research><Research Resources><Resources><Sampling><Surgeon><Time><Treatment Effectiveness><Universities><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Visit><acceptability and feasibility><access to health care><accessibility of health care><accessibility to health care><adulthood><anti-hypertension><blood pressure control><blood pressure management><blood pressure reduction><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><clinical decision support><cost><developmental><diet and exercise><diets><drug adherence><drug compliance><drug/agent><effective therapy><effective treatment><faces><facial><health care access><health care availability><health care personnel><health care service access><health care service availability><health care worker><health provider><health workforce><healthy food><high blood pressure><hyperpiesia><hyperpiesis><hypertension control><hypertension management><hypertension treatment><hypertensive disease><hypertensive disorder><improved><inadequate health literacy><informant><low health literacy><lower BP><lower blood pressure><lowers blood pressure><medical personnel><medication adherence><medication compliance><medication non-adherence><medication nonadherence><mortality><patient barriers><patient centered><patient oriented><patient population><patient response><patient specific response><patient-level barriers><poor health literacy><population health><programs><qualitative reasoning><reduce BP><reduce blood pressure><reduced health literacy><reduction in BP><reduction in blood pressure><response><responsive patient><social health determinants><support tools><tool><treatment provider>
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Robert M. Cannon

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 10/100
Active award
$222,750
FY 2025

Project Title

A Social Determinants of Health Index for Transplant Access

Grant Number:

1R03DK139236-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2025

End Date:

8/31/2027

Project Abstract

Summary: Social determinants of health (SDOH) are now widely recognized to play a role in many chronic health conditions. With this recognition, there is a growing body of literature suggesting an important role of SDOH in access to transplantation services for end stage liver and kidney disease as ...

Research Terms

<Address><Agreement><Algorithms><American><Area><Catchment Area><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Cessation of life><Chronic><Community Health><Community Surveys><Country><County><Data><Data Bases><Data Collection><Databases><Death><Dependence><Development><Dialysis><Dialysis procedure><ESKD><ESRD><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Equity><Foundations><Future><Geographic Area><Geographic Locations><Geographic Region><Geographical Location><Geography><Grafting Procedure><Health><Health Resources><Hepatic Transplantation><Housing><Impoverished><Individual><Inequity><Intestinal><Intestines><Kidney><Kidney Diseases><Kidney Grafting><Kidney Transplantation><Kidney Transplants><Kidney Urinary System><Knowledge><Literature><Liver><Liver Grafting><Liver Transplant><Measures><Mind><Modeling><Nephropathy><Organ Donor><Organ Procurements><Organ Transplantation><Organ Transplants><Outcome><Patients><Play><Policies><Population><Poverty><Prevalence><Process><Publications><Renal Disease><Renal Grafting><Renal Transplantation><Renal Transplants><Research><Risk Adjustment><Role><Scientific Publication><Services><Source><Standardization><System><Time><Transplantation><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Urbanization><Vulnerable Populations><Waiting Lists><Wood><Wood material><Work><base><bases><bowel><career><community-based health><data base><density><deprivation><design><designing><developmental><dialysis therapy><end stage liver disease><end stage liver failure><geographic site><hepatic body system><hepatic organ system><indexing><kidney disorder><kidney tx><liver transplantation><model building><organ allocation><organ allograft><organ graft><organ procurement transplantation network><organ xenograft><outreach><prevent><preventing><renal><renal disorder><risk stratification><social determinants><social health determinants><social role><social vulnerability><sociodeterminant><stratify risk><transplant><transplant centers><under served area><under served geographic area><under served location><under served region><underserved area><underserved geographic area><underserved location><underserved region><vulnerable group><vulnerable individual><vulnerable people><waitlist>
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Helen Burton Murray

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Active award
$201,000
FY 2025

Project Title

Problematic avoidant/restrictive eating in adults with functional dyspepsia: the role of endogenous oxytocin and glucagon-like peptide 1

Grant Number:

1R03DK144287-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Functional dyspepsia (FD) is a chronic gastrointestinal functional/motility disorder that affects up to 12% of US adults with significant morbidity and healthcare costs, and limited treatment options. Detrimental eating-related medical consequences are frequent in FD, with a...

Research Terms

<21+ years old><Address><Adult><Adult Human><Affect><Ancillary Study><Anti-Anxiety Agents><Anti-Anxiety Drugs><Antihormone Agents><Anxiolytic Agents><Anxiolytics><Appetite><Appetite Regulation><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biological><Biological Markers><Blood Sample><Blood specimen><Body Image><Body Weight decreased><CCK><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Communication and Signaling><Cell Signaling><Cholecystokinin><Chronic><Cognition Therapy><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Complement><Complement Proteins><Conditioning Therapy><Cross Sectional Analysis><Cross-Sectional Analyses><Cross-Sectional Studies><Cross-Sectional Survey><Data><Desire for food><Dietary Intervention><Disease Frequency Surveys><Distress><Dysfunction><Dyspepsia><Eating><Endocrine><Endocrine Gland Secretion><Epigastric><Evaluation><Fasting><Food><Food Intake><Functional disorder><Funding><Future><GLP-1><Glp-1><Health Care Costs><Health Costs><Home><Hormone Antagonists><Hormones><Impairment><Indigestion><Intervention><Intracellular Communication and Signaling><Investigators><K-Awards><K-Series Research Career Programs><L-tyrosyl-L-tyrosine><Link><Maintenance><Malnutrition><Medical><Minor Tranquilizing Agents><Morbidity><Morbidity - disease rate><Nausea><Nutrition Interventions><Nutritional Deficiency><Nutritional Interventions><Observation research><Observation study><Observational Study><Observational research><Ocytocin><Outcome><Oxytocin><PYY Peptide><Pain><Painful><Pancreozymin><Parents><Participant><Patients><Peptide YY><Phase><Physiopathology><Property><QOL><Quality of life><Randomized, Controlled Trials><Recombinant Oxytocin><Research><Research Career Program><Research Personnel><Researchers><Role><Satiation><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Stomach><Symptoms><Testing><Therapeutic Agents><Therapeutic Hormone><Training><Tyr-Tyr><Undernutrition><Uropancreozymin><Weight Gain><Weight Increase><Weight Loss><Weight Reduction><adulthood><avoidant restrictive food intake disorder><behavior intervention><behavioral intervention><bio-markers><biobehavior><biobehavioral><biologic><biologic marker><biological signal transduction><biomarker><body perception><body weight gain><body weight increase><body weight loss><care as usual><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><cohort><compare to control><comparison control><complementation><conditioned fear><diet intervention><dietary deficiency><dysmotility><dysmotility syndrome><early fullness><early satiation><early satiety><eat less><fasted><fasts><fear conditioning><food avoidance><gastric><gastrointestinal><glucagon-like peptide 1><homes><hormone inhibitor><improved><innovate><innovation><innovative><interdisciplinary approach><malnourished><manage symptom><meeting><meetings><motility disorder><multidisciplinary><multidisciplinary approach><novel><nutrition deficiency><nutrition deficiency disorder><nutritional deficiency disorder><parent><pathophysiology><patient oriented research><patient oriented study><peptide tyrosine-tyrosine><randomized control trial><rate of change><reduced eating><reduced food intake><restrictive eating><satiated early><satiety><social role><symptom management><treatment as usual><tyrosyltyrosine><usual care><wt gain><wt-loss>
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Nidhya Navanandan

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 10/100
Active award
$189,000
FY 2025

Project Title

Environmental Predictors of Treatment Responsiveness for Pediatric Acute Asthma Exacerbations

Grant Number:

1R03HL180785-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/15/2025

End Date:

8/31/2027

Project Abstract

PROJECT SUMMARY Acute exacerbations are the primary cause of morbidity and mortality among children with asthma. Current treatment for acute asthma exacerbations in the pediatric emergency department (ED) follows a “one-size-fits- all” approach, including inhaled bronchodilators and systemic cortic...

Research Terms

<0-11 years old><Accident and Emergency department><Accounting><Acute><Adrenal Cortex Hormones><Air><Air Pollutants><Air Pollution><Allergens><Asthma><Asthma in Children><Automobile Driving><Biological><Blood Banks><Bronchial Asthma><Bronchial-Dilating Agents><Bronchodilator Agents><Bronchodilators><Child><Child Youth><Childhood><Childhood Asthma><Children (0-21)><Clinical><Clinical Data><Corticoids><Corticosteroids><Data><Development><Disparity population><ED visit><ER visit><Emergency Department><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room><Emergency room visit><Enrollment><Environmental Factor><Environmental Protection Agency><Environmental Risk Factor><Heterogeneity><Home><Hospital Admission><Hospitalization><IgE><Immunoglobulin E><Incidence><Inflammatory><Inhalant dose form><Inhalation><Inhaling><K23 Award><K23 Mechanism><K23 Program><Measures><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Modeling><Monitor><Morbidity><Morbidity - disease rate><NHLBI><National Heart, Lung, and Blood Institute><Oscillometry><Outcome><Participant><Pathway interactions><Pediatric asthma><Phenotype><Physiologic><Physiological><Pilot Projects><Prediction of Response to Therapy><Research><Research Resources><Resources><Risk><Role><Severities><Testing><Therapeutic Intervention><Time><United States Environmental Protection Agency><Validation><Viral><Viral Diseases><Virus><Virus Diseases><Vulnerable Populations><Wildfire><Work><aeroallergens><airborn allergen><airborne allergen><airflow limitation><airflow obstruction><airway limitation><airway obstruction><ambient air pollution><asthma attack><asthma exacerbation><biologic><clinical predictors><developmental><disadvantaged group><disadvantaged individual><disadvantaged people><disadvantaged population><disadvantaged subgroup><disparities across groups><disparity across subgroups><disparity among groups><disparity among subgroups><disparity between groups><disparity between subgroups><driving><enroll><environmental allergen><environmental risk><exacerbation in asthma><exacerbation prone asthma><exacerbation prone asthmatic><experience><global temperature><group disparity><group inequality><group inequity><homes><improved><improved outcome><indexing><inequalities among populations><inequalities between populations><inequalities in populations><inequality across populations><inequality among groups><inequality between groups><inequality in groups><inequities among populations><inequities between populations><inequities in populations><inequity across groups><inequity across populations><inequity between groups><inequity in groups><inhalant><innovate><innovation><innovative><intervention therapy><kids><lumen dilator><mortality><obstructed airflow><obstructed airway><oscillography><outdoor air pollution><pathway><pediatric><pediatric emergency><pilot study><population inequality><population inequity><predict responsiveness><predict therapeutic response><predict therapy response><predicting response><respiratory airway obstruction><respiratory virus><response><response to therapy><response to treatment><social role><subgroup disparity><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic response><therapeutically effective><therapy prediction><therapy response><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><treatment strategy><unequal group><unequal population><validations><viral infection><virus infection><virus-induced disease><vulnerable group><vulnerable individual><vulnerable people><web site><website><wild fire><wildland fire><youngster>
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Patricia Vega Fernandez

CINCINNATI CHILDRENS HOSP MED CTR, CINCINNATI, OH

Exploratory lead · 10/100
Active award
$162,000
FY 2025

Project Title

A Novel Ultrasound Score to Improve the Assessment of Joint Inflammation in Children with Chronic Musculoskeletal Pain

Grant Number:

1R03TR004974-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Candidate: Patricia Vega-Fernandez, MD MSc RhMSUS is a pediatric rheumatologist whose overarching career goal is to improve the outcomes of children affected by autoimmune rheumatologic diseases through a career as an independent translational scientist focused on biology-ba...

Research Terms

<0-11 years old><Address><Adolescent><Adolescent Youth><Affect><Affective Disorders><Ankle><Anti-Rejection Therapy><Area><Arthralgia><Arthritis><Articular Range of Motion><Autoimmune Diseases><Award><Biological Markers><Biology><Career Mobility><Child><Child Youth><Childhood><Children (0-21)><Children's Hospital><Chronic Childhood Arthritis><Clinic><Clinical><Clinical Markers><Clinical Research><Clinical Study><Clinical assessments><Cognition Therapy><Cognitive Psychotherapy><Cognitive Therapy><Cognitive treatment><Collaborations><Complement><Complement Proteins><Data><Decision Making><Detection><Development><Diagnosis><Diagnostic><Diagnostic Imaging><Disease><Disease Management><Disorder><Disorder Management><Doctor of Philosophy><Dysfunction><Environment><Evaluation><Fingers><Foundations><Functional disorder><Funding><Goals><Health><Image><Imaging Device><Imaging Instrument><Imaging Tool><Immunosuppressants><Immunosuppressive Agents><Immunosuppressive Therapy><Immunosuppressive drug><Immunosuppressive treatment><Inflammatory><Investigators><Joint Pain><Joint Range of Motion><Joints><Juvenile Chronic Arthritis><Juvenile Chronic Polyarthritis><Juvenile Rheumatoid Arthritis><Knee><Knowledge><Long-term pain><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medical Inspection><Medical center><Mentors><Mentorship><Mood Disorders><Musculoskeletal Pain Disorder><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Neurobiology><Nuclear Magnetic Resonance Imaging><Outcome><Palpation><Patients><Pediatric Hospitals><Pediatrics><Persistent pain><Ph.D.><PhD><Physical Examination><Physiopathology><Prevalence><Process><Protocol><Protocols documentation><ROC Analyses><ROC Curve><Regio tarsalis><Reporting><Reproducibility><Research><Research Activity><Research Personnel><Researchers><Rheumatic Diseases><Rheumatism><Rheumatologic Diseases><Rheumatologic Disorder><Rheumatology><Risk><Schools><Scientist><Seasons><Secure><Social isolation><Symptoms><Testing><Therapeutic immunosuppression><Time><Training><Translational Research><Translational Science><Uncertainty><United States National Institutes of Health><Universities><Validity and Reliability><Zeugmatography><accurate diagnostics><arthritic><artificial immunosuppression><assess effectiveness><associate faculty><associate professor><autoimmune condition><autoimmune disorder><autoimmune rheumatic disease><autoimmune rheumatologic disease><autoimmunity disease><bio-markers><biologic marker><biomarker><career><career advancement><career transition><chronic MSK pain><chronic musculoskeletal pain><chronic pain><clinical biomarkers><clinical center><clinical significance><clinically significant><clinically useful biomarkers><cognitive behavior intervention><cognitive behavior modification><cognitive behavior therapy><cognitive behavioral intervention><cognitive behavioral modification><cognitive behavioral therapy><cognitive behavioral treatment><complementation><constant pain><customized therapy><customized treatment><determine effectiveness><developmental><doubt><effectiveness assessment><effectiveness evaluation><evaluate effectiveness><examine effectiveness><experience><fundamental research><health related quality of life><imaging><imaging biomarker><imaging marker><imaging-based biological marker><imaging-based biomarker><imaging-based marker><immune suppressive agent><immune suppressor><immunosuppression therapy><immunosuppressive substance><immunosuppressor><improved><improved outcome><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><inflamed joint><innovate><innovation><innovative><joint damage><joint inflammation><joint injury><joint swelling><joint trauma><juvenile><juvenile arthritis><juvenile fibromyalgia><juvenile human><juvenile idiopathic arthritis><juvenile onset fibromyalgia><kids><lasting pain><mid-career faculty><midcareer faculty><musculoskeletal ultrasound><neurobiological><novel><on-going pain><ongoing pain><participant enrollment><pathophysiology><patient enrollment><patient specific therapies><patient specific treatment><pediatric><pediatric rheumatic diseases><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><phonoarthrography><physical conditioning><physical examinations><physical health><point of care><range of motion><receiver operating characteristic analyses><receiver operating characteristic curve><response to therapy><response to treatment><rheumatologist><skeletal muscle ultrasound><skeletal sonography><skills><soft tissue><tailored medical treatment><tailored therapy><tailored treatment><therapeutic response><therapy response><tool><translation research><translational investigation><translational investigator><translational researcher><translational scientist><treatment planning><treatment response><treatment responsiveness><treatment strategy><ultrasound><unique treatment><youngster>
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Denise Finley Lillvis

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Exploratory lead · 10/100
Active award
$159,103
FY 2024

Project Title

Experiences of Parents Seeking Emergency Care for Injured Children with Special Health Care Needs

Grant Number:

1R03TR005206-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2024

End Date:

7/31/2026

Project Abstract

Children and youth with special health care needs (CYSHCN)—which include children with chronic conditions such as Asthma, Autism, Depression, Down Syndrome, or Spina Bifida—are at greater risk of developing hospital complications following physical trauma. However, the mechanisms behind this elevate...

Research Terms

<0-11 years old><ASD><Academy><Address><Affect><American><Asthma><Asystole><Autism><Autistic Disorder><Award><Behavioral><Bronchial Asthma><Cardiac Arrest><Caring><Child><Child Care><Child Health><Child Youth><Child health care><Childhood Injury><Children (0-21)><Chronic><Cognitive Discrimination><Complement><Complement Proteins><Complex><Data><Demographic Factors><Development><Discrimination><Disparities><Disparity><Down's Syndrome><ED care><ER care><Early Infantile Autism><Education><Educational aspects><Elements><Emergencies><Emergency Care><Emergency Department care><Emergency Room care><Emergency Situation><Emergency health care><Emergency healthcare><Emergency medical care><Emotional><Ensure><Face><Family><Family Care Giver><Family Caregiver><Family Demographies><Funding><Future><Goals><Guidelines><Health><Healthcare><Healthcare Delivery><Heart Arrest><Hospital Costs><Hospital acquired complications><Hospital complications><Hospitalization cost><Hospitals><Infantile Autism><Injury><Intervention><Intervention Strategies><Interview><Investigators><Kanner's Syndrome><Knowledge><Langdon Down syndrome><Length of Stay><Letters><Maternal and Child Health><Measurement><Medical><Mental Depression><Mission><Modality><Mongolism><NIH><National Institutes of Health><Number of Days in Hospital><Operating Rooms><Outcome><Parents><Pediatrics><Population><Position><Positioning Attribute><Pre-hospital care><Pre-hospitalization care><Prehospital care><Prehospitalization care><Provider><Public Health><Puericulture><QOC><Quality of Care><Questionnaires><Reporting><Research><Research Personnel><Researchers><Risk><Sampling><Schistorrhachis><Science><Sight><Spina Bifida><Spinal Dysraphia><Spinal Dysraphism><Structure><Survey Instrument><Surveys><System><Testing><Trauma><Trisomy 21><United States National Institutes of Health><Vision><Voice><Work><Youth><Youth 10-21><adolescent health><adolescent trauma><adverse consequence><adverse outcome><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><care delivery><care giver strain><care providers><caregiver strain><child healthcare><childhood trauma><chromosome 21 trisomy syndrome><cleft spine><complementation><congenital acromicria syndrome><depression><developmental><disparity elimination><disparity in care><disparity in health><disparity in healthcare><eliminate disparities><eliminating disparities><experience><faces><facial><health and care delivery><health care><health care delivery><health care disparity><health care inequality><health care inequity><health delivery systems><health disparity><health services delivery><healthcare disparity><healthcare inequality><healthcare inequity><hospital care><hospital days><hospital length of stay><hospital related complications><hospital stay><hospital-associated complications><hydrocele spinalis><improved><injured child><injured children><injuries><injury in children><innovate><innovation><innovative><interest><interventional strategy><kids><morbus Down><nosocomial complications><parent><pediatric care><pediatric health care><pediatric healthcare><pediatric injury><pediatric trauma><pseudohypertrophic progressive muscular dystrophy><rachischisis posterior><recruit><resilience><resilient><tertiary care><translational investigator><translational researcher><translational scientist><trauma care><trauma in children><trisomy 21 syndrome><visual function><youngster>
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Soyang Kwon

NORTHWESTERN UNIVERSITY, CHICAGO, IL

Exploratory lead · 10/100
Active award
$157,531
FY 2024

Project Title

Physical activity in South Asian Youth

Grant Number:

1R03HD113876-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/10/2024

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY South Asian is one of the fastest growing ethnic groups in the United States (US). The striking overweight and obesity prevalence (78%) among foreign-born South Asian American adults is a public health concern, as it affects not only their own health, but transgenerational obesity ri...

Research Terms

<0-11 years old><16 year old><16 years of age><21+ years old><Acceleration><Accelerometer><Acculturation><Address><Adoption><Adult><Adult Human><Affect><Aggregated Data><Area><Asian><Asian Americans><Asian Females><Asian Indian><Asian Women><Attitude><BMI><BMI percentile><BMI z-score><Behavior><Black><Black race><Body Composition><Body fat><Body mass index><British><Chicago><Child><Child Rearing><Child Youth><Children (0-21)><Chinese><Classification><Clinical Trials><Communities><Conflict><Conflict (Psychology)><Country><Cultural Assimilation><Cultural Characteristics><DEXA><DXA><Data><Data Aggregation><Data Analyses><Data Analysis><Data Sources><Daughter><Devices><Dual-Energy X-Ray Absorptiometry><Dual-Energy Xray Absorptiometry><Equation><Ethnic Group><Ethnic People><Ethnic Population><Ethnic individual><Ethnicity People><Ethnicity Population><Evaluation><Family><Fats><Fatty acid glycerol esters><Filipino><Foundations><Gender><Generations><Goals><Health><Hispanic><Immigrant><Immigrant family><Knowledge><Leanness><Low Prevalence><Machine Learning><Maps><Masks><Measures><Methods><Modeling><Mothers><NHANES><National Health and Nutrition Examination Survey><Obesity><Output><Over weight><Overweight><Parenting><Parenting behavior><Parents><Participant><Patient Self-Report><Physical activity><Prevalence><Public Health><Questionnaires><Quetelet index><Racial Group><Religion><Research><Research Activity><Risk><Self evaluation><Self-Examination><Self-Report><Self-Surveillance><South Asian><Sports><Subgroup><Survey Instrument><Surveys><Systematics><Thinness><Transportation><United States><Variant><Variation><Wrist><Youth><Youth 10-21><accelerometry><actigraph><actigraphy><activity monitor><activity tracker><adiposity><adulthood><age 16 years><aged><analytical method><caucasian American><childrearing><corpulence><cost efficient><data interpretation><design><designing><ethnic subgroup><ethnicity group><exercise intervention><fitness><innovate><innovation><innovative><intervention design><kids><lack of physical activity><machine based learning><modifiable behavior><muscle strength><obesity prevention><obesity risk><parent><physical activity intervention><physical inactivity><prevent obesity><racial population><racial subgroup><religious><risk for obesity><risk of obesity><sixteen year old><sixteen years of age><therapy design><treatment design><vigorous intensity><white American><youngster>
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Yan Wang

UNIVERSITY OF CALIFORNIA LOS ANGELES, LOS ANGELES, CA

Exploratory lead · 10/100
Active award
$157,500
FY 2025

Project Title

Longitudinal Oral Microbiome for HIV/HEU/HUU Children Aged 3-4 in Western Kenya

Grant Number:

5R03DE033631-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2024

End Date:

8/31/2026

Project Abstract

ABSTRACT As of 2022, HIV infection and HIV-related diseases remain among the leading causes of death for children under five, despite the availability of antiretroviral therapy (ART). Children living in Sub-Saharan Africa face the highest mortality rate, with approximately 1 in 13 children dying bef...

Research Terms

<0-11 years old><14 year old><14 years of age><3 year old><3 years of age><AIDS Virus><AIDS/HIV><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Active Follow-up><Affect><Africa South of the Sahara><Age><Anti-HIV Positivity><Area><Behavior><Birth><Breast Feeding><Breast fed><Breastfed><Breastfeeding><Caries><Caring><Cause of Death><Child><Child Youth><Children (0-21)><County><Data><Death Rate><Deciduous Dentition><Dental><Dental Care><Dental Decay><Dental Procedure><Dental caries><Development><Disease><Disorder><Educational process of instructing><Face><Foundations><Future><Generalized Growth><Goals><Growth><HIV><HIV Infections><HIV Positive><HIV Positivity><HIV Seroconversion><HIV Seropositivity><HIV antibody positive><HIV-exposed uninfected infant><HIV/AIDS><HTLV-III Infections><HTLV-III Seroconversion><HTLV-III Seropositivity><HTLV-III-LAV Infections><Health><Health Status><High Prevalence><Hospital Admission><Hospital Referrals><Hospitalization><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Incidence><Infrastructure><Intervention><Investigators><Kenya><LAV-HTLV-III><Level of Health><Life><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Lymphadenopathy-Associated Virus><Medical><Methods><Modeling><Mother-to-child HIV transmission><Mothers><Mouth Diseases><Mouth microbiome><Nutrition><Oral><Oral Cavity Disease><Oral Cavity Disorder><Oral Disease><Oral Disorder><Oral Manifestations><Oral health><Outcome><Parents><Parturition><Pattern><Personal Satisfaction><Phenotype><Pregnant Women><Prevention><Primary Care><Primary Dentition><Primary Tooth><QOL><Quality of life><R-Series Research Projects><R01 Mechanism><R01 Program><RNA, Ribosomal, 16S><Research><Research Grants><Research Personnel><Research Project Grants><Research Projects><Researchers><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Saliva><Sampling><Social Interaction><Sub-Saharan Africa><Subsaharan Africa><Swab><Teaching><Temporary Tooth><Time><Tissue Growth><Transmission><Virus-HIV><Visit><active followup><age 14 years><age 3 years><age stratification><aged><ages><antiretroviral therapy><antiretroviral treatment><bacterial community><care resources><cohort><cost effective><deciduous tooth><dental health><dental service><developmental><evidence base><expectant mother><expectant women><expecting mother><expecting women><exposed in utero><faces><facial><fetal exposure><follow up><follow-up><followed up><followup><fourteen year old><fourteen years of age><health care resources><health level><improved><in utero exposure><individuals who are pregnant><intra-uterine environmental exposure><intrauterine environmental exposure><kids><microbial><microbial consortia><microbial flora><microbiome><microbiota><microflora><mortality rate><mortality ratio><mouth disorder><multispecies consortia><ontogeny><oral condition><oral microbial community><oral microbiome><oral microbiota><oral microflora><parent><people who are pregnant><population health><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal exposure><prenatally exposed><routine care><scale up><sex><those who are pregnant><three year old><three years of age><tooth decay><transmission process><well-being><wellbeing><women who are pregnant><youngster>
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Dhimiter Bello

UNIVERSITY OF MASSACHUSETTS LOWELL, LOWELL, MA

Exploratory lead · 10/100
Active award
$157,437
FY 2025

Project Title

Defining the Urinary, Biliary and Fecal Excretion of Diverse PFAS and the Impact of Dietary Fiber

Grant Number:

1R03ES037466-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/10/2025

End Date:

5/9/2027

Project Abstract

Project Summary Per- and polyfluoroalkyl substances (PFAS) are now a part of the everyday lives of most Americans. PFAS are strongly associated with adverse human health effects including, increased serum low density lipoprotein cholesterol, reduced antibody responses to vaccination, altered liver s...

Research Terms

<Acceleration><American><Animal Model><Animal Models and Related Studies><Antibody Response><Automobile Driving><Bile><Bile Acids><Bile Juice><Bile fluid><Biliary><Biological Markers><Birth Weight><Blood Serum><Body Burden><Carrier Proteins><Characteristics><Cholesterol><Cholestyramine><Cholestyramine Resin><Circulation><Clinical><Colestyramine><Consumption><Contamination in food><Data><Diet><Dietary Fiber><Domestic Rabbit><EC 2.7.7.49><Eating><Engineering><Enterocytes><Epithelial Cells><Equilibrium><Excretory function><Feces><Female><Food Contamination><Food Intake><Gel><Gene Expression><Gestational Hypertension><Grant><Guidelines><Health><Human><Hydrogen Oxide><Hypertension induced by pregnancy><Interruption><Intervention><Intervention Strategies><Kidney><Kidney Urinary System><LDL Cholesterol><LDL Cholesterol Lipoproteins><Liquid Chromatography><Liver><Low Density Lipoprotein Cholesterol><Maintenance><Measures><Medical><Medicine><Methods><Mice><Mice Mammals><Modern Man><Molecular><Murine><Mus><NHANES><National Academy of Sciences><National Health and Nutrition Examination Survey><Nuclear Receptors><Oryctolagus cuniculus><Outcome><PFAS><PPAR alpha><PPAR-α><PPARalpha><PPARα><Peroxisome Proliferator-Activated Receptor alpha><Peroxisome Proliferator-Activated Receptor α><Persons><Physiologic><Physiological><Poly-fluoroalkyl substances><Pregnancy Associated Hypertension><RNA Transcriptase><RNA-Dependent DNA Polymerase><RNA-Directed DNA Polymerase><Rabbits><Rabbits Mammals><Research><Research Design><Reverse Transcriptase><Revertase><Risk><Rodent><Rodentia><Rodents Mammals><Role><Sampling><Serum><Study Type><System><Testing><Time><Toxic effect><Toxicities><Toxicokinetics><Transport Protein Gene><Transport Proteins><Transporter Protein><United States National Academy of Sciences><Urine><Vaccination><Water><absorption><balance><balance function><beta-Lipoprotein Cholesterol><bio-markers><bioaccumulation><biologic marker><biomarker><dietary><diets><drinking water><driving><excretion><experience><experiment><experimental research><experimental study><experiments><hepatic body system><hepatic organ system><human male><hypertension during pregnancy><hypertension in pregnancy><hypertensive pregnancy><ileum><interest><intervention design><model of animal><novel><perfluorinated alkyl substances><perfluoroalkyl substances><perfluoroalkylated substances><perfluorooctanoate><perfluorooctanoic acid><polyfluorinated alkyl substances><polyfluoroalkyl substances><pregnancy characterized by hypertension><pregnancy hypertension><pregnancy-related hypertension><prevent><preventing><renal><renal epithelium><response><reuptake><social role><stem><stool><study design><tandem mass spectrometry><therapy design><treatment design><uptake><urinary><whole grain><♀>
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Cassandra D Gipson-Reichardt

UNIVERSITY OF KENTUCKY, LEXINGTON, KY

Exploratory lead · 10/100
Active award
$157,224
FY 2025

Project Title

Neuroimmune and Cognitive Consequences of Nicotine Use in a Rodent Model of HIV: Implications for Anti-Retroviral Therapies

Grant Number:

5R03DA061626-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2024

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT This A-START R03 will examine the role of volitional nicotine use in exacerbating neuroimmune consequences of HIV using a rat model in support of a larger R01. Clinically, persons living with HIV (PLWH) are 2-3 times more likely than the average population to use nicotine-co...

Research Terms

<AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Adherence><Age><Amygdala><Amygdaloid Body><Amygdaloid Nucleus><Amygdaloid structure><Animals><Anxiety><Blood Serum><Brain><Brain Nervous System><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chronic><Clinical><Cognition><Cognitive><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Common Rat Strains><Consequences of HIV><Coping Skills><Cytokine Suppression><Data><Disturbance in cognition><Drug Therapy><Drug usage><Encephalon><Female><Genes><Goals><HIV><HIV 1 associated neurocognitive disorder><HIV Infections><HIV associated neurocognitive deficit><HIV associated neurocognitive impairment><HIV induced neurocognitive deficit><HIV induced neurocognitive impairment><HIV neurocognitive impairment><HIV-1 associated neurocognitive deficit><HIV-1 associated neurocognitive disorder><HIV-1 associated neurocognitive impairment><HIV-associated neurocognitive disorder><HTLV-III Infections><HTLV-III-LAV Infections><Hortega cell><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><IQ Deficit><Immune><Immune system><Immunes><Impaired cognition><Impairment><Infection><Inflammation><Inflammatory><Intake><Intracellular Communication and Signaling><LAV-HTLV-III><Lymphadenopathy-Associated Virus><Macrophage><Measures><Memory><Mental Depression><Microglia><Modeling><Motivation><Mφ><Neurobiology><Neurocognition><Neurocognitive><Neurocognitive Deficit><Neurocognitive Impairment in HIV><Neurocognitive Impairment in HIV-1><Neuroimmune><Neuroimmune system><Nicotine><Nicotine Dependence><Nucleus Accumbens><Outcome><Pathway interactions><Performance><Peripheral><Persons><Pharmacological Treatment><Pharmacotherapy><Population><Pre-Clinical Model><Preclinical Models><Prefrontal Cortex><Rat><Rats Mammals><Rattus><Reporting><Research><Rewards><Rodent><Rodent Model><Rodentia><Rodents Mammals><Role><Saline><Saline Solution><Sampling><Self Administered><Self Administration><Serum><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Smoking><Testing><Ventral Striatum><Viral><Viral reservoir><Virus><Virus reservoir><Virus-HIV><Withdrawal><Woman><Work><addiction><addictive disorder><ages><amygdaloid nuclear complex><antiretroviral therapy><antiretroviral treatment><anxiety-like behavior><biological signal transduction><cease smoking><co-morbid><co-morbidity><cognitive change><cognitive dysfunction><cognitive enhancement><cognitive function><cognitive loss><cognitive performance><cognitive task><comorbidity><coping><coping strategy><cytokine><depression><drug intervention><drug treatment><drug use><experience><exposure to nicotine><field based data><field learning><field study><field test><gitter cell><improved><intelligence quotient deficit><life year loss><mesoglia><microglial cell><microgliocyte><motivated behavior><neural inflammation><neurobehavioral><neurobiological><neurobiological mechanism><neurocognitive decline><neurocognitive impairment><neuroinflammation><neuroinflammatory><nicotine addiction><nicotine consumption><nicotine dependent><nicotine exposure><nicotine seeking><nicotine seeking behavior><nicotine self-administration><nicotine use><novel><pathway><perivascular glial cell><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><pre-clinical evaluation><preclinical evaluation><quit smoking><sex><smoking cessation><smoking initiation><social role><stop smoking><years of life lost><♀>
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Joseph S Lonstein

MICHIGAN STATE UNIVERSITY, EAST LANSING, MI

Exploratory lead · 10/100
Active award
$157,000
FY 2025

Project Title

Psychobiological Mediators of the Impact of Pregnancy Stress on Maternal Sensitivity

Grant Number:

1R03HD111716-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/8/2025

End Date:

4/30/2027

Project Abstract

PROJECT SUMMARY Poor mental health is prevalent in stressful pregnancies, with at least 10-15% of pregnant women above the clinical thresholds for a mental health disorder. Mothers affected by mental health disorders are less likely to engage in sensitive caregiving and may be at risk for engaging ...

Research Terms

<0-11 years old><Acute><Aeroseb-HC><Affect><Anxiety><Aquadiol><Basic Research><Basic Science><Behavior><Biological><Caring><Cessation of life><Cetacort><Child><Child Youth><Children (0-21)><Chronic><Clinical><Corpus Luteum Hormone><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Data><Data Set><Death><Delta4-pregnene-3,20-dione><Dermacort><Dimenformon><Diogyn><Diogynets><Education><Educational aspects><Eldecort><Endocrine><Endocrine Gland Secretion><Endocrine disruption><Estrace><Estradiol><Estradiol-17 beta><Estradiol-17beta><Estraldine><Female Groups><Funding><Gestation><Goals><Gonadal Steroid Hormones><Groups at risk><Health><High Risk Woman><Hormones><Human><Hydrocortisone><Hydrocortone><Hytone><Impaired health><Impairment><Impoverished><Individual><Infant><Intervention><Interview><Knowledge><Life Stress><Long-term prospective studies><Longitudinal Studies><Mammalia><Mammals><Measures><Mediating><Mediator><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Methods><Michigan><Modeling><Modern Man><Mothers><NICHD><National Institute of Child Health and Human Development><Nutracort><Outcome><Ovocyclin><Ovocylin><PTSD><Pattern><People at risk><Persons at risk><Population Heterogeneity><Populations at Risk><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Post-partum Women><Postpartum Period><Postpartum Women><Posttraumatic Neuroses><Poverty><Pregn-4-ene-3,20-dione><Pregnancy><Pregnant Women><Pregnenedione><Prevention><Proctocort><Progesterone><Progynon><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychosocial Stress><Questionnaires><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Research><Research Grants><Research Project Grants><Research Projects><Risk><Sampling><Sex Hormones><Sex Steroid Hormones><Shapes><Stress><Symptoms><System><Therapeutic Estradiol><Therapeutic Hormone><Therapeutic Progesterone><Time><Woman><Women's Group><Work><at-risk females><at-risk women><biologic><biopsychosocial><biopsychosocial factor><biopsychosocial variable><care giving><caregiving><depression><diverse populations><endocrine disrupting><expectant mother><expectant women><expecting mother><expecting women><experience><female treatment><females at high risk><fetal stress><gonadal steroids><healthy pregnancy><heterogeneous population><high risk females><individuals who are pregnant><kids><long-term study><longitudinal outcome studies><longitudinal, prospective study><loved ones><maternal care giving><maternal caregiving><mental illness><partner violence><people who are pregnant><population diversity><post-partum><post-trauma stress disorder><posttrauma stress disorder><pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal stress><psychiatric illness><psychobiologic><psychobiological><psychologic><psychological><psychological disorder><racial><racial background><racial origin><racism><research study><residence><residential building><residential site><secondary analysis><sex steroid><those who are pregnant><trait><traumatic neurosis><treat females><treat women><treatment among females><treatment among women><treatment in females><treatment in women><violent partner><women at high risk><women who are pregnant><women's treatment><youngster>
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Amy K. Nuttall

MICHIGAN STATE UNIVERSITY, EAST LANSING, MI

Exploratory lead · 10/100
Active award
$157,000
FY 2025

Project Title

Psychobiological Mediators of the Impact of Pregnancy Stress on Maternal Sensitivity

Grant Number:

1R03HD111716-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/8/2025

End Date:

4/30/2027

Project Abstract

PROJECT SUMMARY Poor mental health is prevalent in stressful pregnancies, with at least 10-15% of pregnant women above the clinical thresholds for a mental health disorder. Mothers affected by mental health disorders are less likely to engage in sensitive caregiving and may be at risk for engaging ...

Research Terms

<0-11 years old><Acute><Aeroseb-HC><Affect><Anxiety><Aquadiol><Basic Research><Basic Science><Behavior><Biological><Caring><Cessation of life><Cetacort><Child><Child Youth><Children (0-21)><Chronic><Clinical><Corpus Luteum Hormone><Cort-Dome><Cortef><Cortenema><Cortisol><Cortispray><Cortril><Data><Data Set><Death><Delta4-pregnene-3,20-dione><Dermacort><Dimenformon><Diogyn><Diogynets><Education><Educational aspects><Eldecort><Endocrine><Endocrine Gland Secretion><Endocrine disruption><Estrace><Estradiol><Estradiol-17 beta><Estradiol-17beta><Estraldine><Female Groups><Funding><Gestation><Goals><Gonadal Steroid Hormones><Groups at risk><Health><High Risk Woman><Hormones><Human><Hydrocortisone><Hydrocortone><Hytone><Impaired health><Impairment><Impoverished><Individual><Infant><Intervention><Interview><Knowledge><Life Stress><Long-term prospective studies><Longitudinal Studies><Mammalia><Mammals><Measures><Mediating><Mediator><Mental Depression><Mental Health><Mental Hygiene><Mental disorders><Mental health disorders><Methods><Michigan><Modeling><Modern Man><Mothers><NICHD><National Institute of Child Health and Human Development><Nutracort><Outcome><Ovocyclin><Ovocylin><PTSD><Pattern><People at risk><Persons at risk><Population Heterogeneity><Populations at Risk><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Post-partum Women><Postpartum Period><Postpartum Women><Posttraumatic Neuroses><Poverty><Pregn-4-ene-3,20-dione><Pregnancy><Pregnant Women><Pregnenedione><Prevention><Proctocort><Progesterone><Progynon><Psychiatric Disease><Psychiatric Disorder><Psychological Health><Psychosocial Stress><Questionnaires><R-Series Research Projects><R01 Mechanism><R01 Program><Race><Races><Research><Research Grants><Research Project Grants><Research Projects><Risk><Sampling><Sex Hormones><Sex Steroid Hormones><Shapes><Stress><Symptoms><System><Therapeutic Estradiol><Therapeutic Hormone><Therapeutic Progesterone><Time><Woman><Women's Group><Work><at-risk females><at-risk women><biologic><biopsychosocial><biopsychosocial factor><biopsychosocial variable><care giving><caregiving><depression><diverse populations><endocrine disrupting><expectant mother><expectant women><expecting mother><expecting women><experience><female treatment><females at high risk><fetal stress><gonadal steroids><healthy pregnancy><heterogeneous population><high risk females><individuals who are pregnant><kids><long-term study><longitudinal outcome studies><longitudinal, prospective study><loved ones><maternal care giving><maternal caregiving><mental illness><partner violence><people who are pregnant><population diversity><post-partum><post-trauma stress disorder><posttrauma stress disorder><pregnant><pregnant females><pregnant mothers><pregnant people><pregnant populations><prenatal stress><psychiatric illness><psychobiologic><psychobiological><psychologic><psychological><psychological disorder><racial><racial background><racial origin><racism><research study><residence><residential building><residential site><secondary analysis><sex steroid><those who are pregnant><trait><traumatic neurosis><treat females><treat women><treatment among females><treatment among women><treatment in females><treatment in women><violent partner><women at high risk><women who are pregnant><women's treatment><youngster>
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Yuan Wang

MICHIGAN STATE UNIVERSITY, EAST LANSING, MI

Exploratory lead · 10/100
Active award
$157,000
FY 2024

Project Title

Critical protein interactions for piRNA biogenesis

Grant Number:

1R03HD110627-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY P-element induced wimpy testis (PIWI)-interacting RNAs (piRNAs) are ~24-34 nt non-coding RNAs that have been discovered in diverse species. Repressing the expression of transposable elements via piRNAs represents a critical defense mechanism for germ cells to maintain genomic integri...

Research Terms

<21+ years old><Adult><Adult Human><Anabolism><Antibodies><Biogenesis><C-terminal><Cell Communication and Signaling><Cell Signaling><Cementation><Communication><Cytoplasm><Cytoplasmic Granules><DNA><DNA Transposable Elements><Defense Mechanisms><Deoxyribonucleic Acid><Development><Doxycycline><Electrons><Elements><Embryo><Embryonic><Exclusion><Failure><Family member><Functional RNA><Gametes><Generations><Genomics><Germ Cells><Germ Lines><Germ-Line Cells><Gonadal structure><Immune Precipitation><Immunoprecipitation><Impairment><Intracellular Communication and Signaling><Knowledge><Lead><Male Contraception><Male Contraceptive Agents><Male Contraceptives><Male Infertility><Mediating><Membrane><Mice><Mice Mammals><Mitochondria><Monitor><Murine><Mus><Mutant Strains Mice><Negative Beta Particle><Negatrons><Neonatal><Non-Coding><Non-Coding RNA><Non-Polyadenylated RNA><Non-translated RNA><Noncoding RNA><Nontranslated RNA><Origin of Life><Outer Mitochondrial Membrane><Pb element><Peptide Domain><Peptides><Pilot Projects><Process><Protein Domains><Proteins><RNA><RNA Gene Products><RNA Seq><RNA sequencing><RNA-Binding Proteins><RNAseq><Repression><Reproductive Cells><Ribonucleic Acid><Ribonucleoproteins><Role><Sex Cell><Signal Transduction><Signal Transduction Systems><Signaling><Somatic Cell><Spermatocytes><Spermatogenesis><Spermatogonia><Spermatophores><Spermiocytes><Tertiary Protein Structure><Testicles><Testing><Testis><Transmission Electron Microscopy><Transposable Elements><Untranslated RNA><Vibramycin><Virus><Withdrawal><adulthood><alpha-6-Deoxyoxytetracycline><biological signal transduction><biosynthesis><developmental><genome integrity><genomic integrity><gonad><gonads><granule><heavy metal Pb><heavy metal lead><initial cell><male antifertility drug><male fertility><male germ cells><membrane structure><mitochondrial><mouse model><mouse mutant><murine model><mutant><new approaches><new drug target><new druggable target><new pharmacotherapy target><new therapeutic target><new therapy target><noncoding><novel><novel approaches><novel drug target><novel druggable target><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic target><novel therapy target><piRNA><pilot study><piwi RNA><postnatal><psychological defense mechanism><recruit><sexual cell><social role><spermatogone><spermatospore><spermigonium><spermospore><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcriptome sequencing><transcriptomic sequencing><vector><vector control>
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Eric Richard Gross

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 10/100
Active award
$156,830
FY 2025

Project Title

Deciphering the role of dipeptidase 2 (DPEP2) to treat surgical pain

Grant Number:

1R03NS147020-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY: Surgical pain is caused by tissue injury and inflammation. To treat surgical pain, people are given opioids which is leading to secondary health problems after surgery including opioid abuse, dependence, and overdose that is driving the United States opioid epidemic. This is particu...

Research Terms

<(TNF)-α><AI Augmented><AI assisted><AI driven><AI enhanced><AI integrated><AI powered><Aging><Amino Acids><Analgesia Tests><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Arachidonic Acids><Artificial Intelligence enhanced><Assay><Augmented by AI><Augmented by the AI><Augmented with AI><Augmented with the AI><Automobile Driving><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Bioassay><Biological Assay><Body Tissues><Cachectin><Catalytic Core><Catalytic Domain><Catalytic Region><Catalytic Site><Catalytic Subunit><Cell Aging><Cell Body><Cell Communication and Signaling><Cell Line><Cell Senescence><Cell Signaling><CellLine><Cells><Cellular Aging><Cellular Senescence><Cellular injury><Clinical><Complex><DNA mutation><Dependence><Dipeptidases><Dose><Dropsy><Drug Interactions><Drugs><ELISA><Edema><Elderly><Enzyme-Linked Immunosorbent Assay><Esteroproteases><Family member><Fibroblasts><Genes><Genetic Change><Genetic defect><Genetic mutation><Goals><HEAL Initiative><HPGF><Hair><Health><Helping End Addiction Long-term><Helping to End Addiction Long-term><Hepatocyte-Stimulating Factor><Hybridoma Growth Factor><Hydrops><IFN-beta 2><IFNB2><IL-6><IL6 Protein><Immune><Immunes><Immunoblotting><Inflammation><Inflammatory><Inflammatory Response><Injury><Interleukin-6><Intracellular Communication and Signaling><LTD4><LTE4><Laboratories><Leukotriene D-4><Leukotriene D4><Leukotriene E-4><Leukotriene E4><Leukotrienes><Luciferase Immunologic><Luciferases><MGI-2><Macrophage><Macrophage-Derived TNF><Measurement><Measures><Mediating><Medication><Methods><Mice><Mice Mammals><Modeling><Molecular><Molecular Target><Monocyte-Derived TNF><Motion><Murine><Mus><Mutation><Myeloid Differentiation-Inducing Protein><Mφ><NIH><National Institutes of Health><Nociception Tests><Operative Procedures><Operative Surgical Procedures><Opiates><Opioid><Otomy><Overdose><Pain><Pain Assessment><Pain Measurement><Pain measure><Painful><Pathway interactions><Peptidases><Peptide Hydrolases><Persons><Pharmaceutical Preparations><Phenotype><Phosphorylation><Plasmacytoma Growth Factor><Play><Polypharmacy><Production><Protease Gene><Proteases><Protein Phosphorylation><Proteinases><Proteins><Proteolytic Enzymes><Proteome><Receptor Protein><Replicative Senescence><Reporter><Research><Rodent><Rodentia><Rodents Mammals><Role><Secondary to><Signal Transduction><Signal Transduction Systems><Signaling><Site><Site-Directed Mutagenesis><Site-Specific Mutagenesis><Skin><Strains Cell Lines><Structure><Surgical><Surgical Interventions><Surgical Procedure><Surgical incisions><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Targeted DNA Modification><Targeted Modification><Testing><Therapeutic><Tissues><Transfection><Tumor Necrosis Factor><Tumor Necrosis Factor Activation><Tumor Necrosis Factor-alpha><United States><United States National Institutes of Health><Western Blotting><Western Immunoblotting><Work><advanced age><age associated alterations><age associated changes><age correlated alterations><age correlated changes><age dependent alterations><age dependent changes><age induced alterations><age induced changes><age related alterations><age related changes><age specific alterations><age specific changes><aging associated alterations><aging associated changes><aging correlated alterations><aging correlated changes><aging dependent alterations><aging dependent changes><aging induced alterations><aging induced changes><aging related alterations><aging related changes><aging specific alterations><aging specific changes><allodynia><alterations with age><aminoacid><artificial intelligence assisted><artificial intelligence augmented><artificial intelligence driven><artificial intelligence integrated><artificial intelligence powered><biological signal transduction><cell damage><cell injury><cellular damage><changes with age><cultured cell line><cysteinyl leukotriene receptor><cytokine><damage to cells><driving><drug metabolism><drug/agent><enhanced with AI><enhanced with Artificial Intelligence><enzyme linked immunoassay><genome mutation><geriatric><hallmarks of aging><incision><inflammatory pain><injuries><injury to cells><injury to tissue><interferon beta 2><luminescence><mechanical allodynia><montelukast><mutant><non-narcotic analgesic><non-opiate analgesic><non-opioid><non-opioid analgesic><non-opioid therapeutics><nonnarcotic analgesics><nonopiate analgesic><nonopioid><nonopioid analgesics><older adult><older adulthood><opiate abuse><opiate crisis><opiate drug abuse><opioid abuse><opioid crisis><opioid drug abuse><opioid epidemic><pain assay><pathway><pillars of aging><protein blotting><receptor><replicative aging><response><senescence and its associated secretory phenotype><senescence associated secretome><senescence associated secretory factors><senescence associated secretory pathway><senescence associated secretory phenotype><senescence associated secretory program><senescence associated secretory proteins><senescent associated secretome><senescent associated secretory phenotype><senior citizen><sex><social role><surgery><surgery pain><surgical pain><therapeutic target><tissue injury><treatment strategy>
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Maria del Mar Romero Lopez

UNIVERSITY OF TEXAS HLTH SCI CTR HOUSTON, HOUSTON, TX

Exploratory lead · 10/100
Active award
$156,000
FY 2025

Project Title

Effects of Earlier And Higher Vitamin D Supplementation in Extremely Preterm Newborns at 2 Years Of Age

Grant Number:

1R03TR005545-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2027

Project Abstract

PROJECT SUMMARY Extremely premature (EP) infants (<28 weeks gestation) often have vitamin D deficiency at birth that worsens in the first month after birth and may have lasting direct or indirect adverse effects on the developing lungs, bones, brain, and immune system, contributing to the high rate...

Research Terms

<0-11 years old><2 year old><2 years of age><21+ years old><25-hydroxyvitamin D><6 year old><6 years of age><Accounting><Active Follow-up><Adult><Adult Human><Adverse effects><Affect><Age><Allergy><Asthma><Asthma in Children><Bayesian Analysis><Bayesian computation><Bayesian inference><Bayesian network analysis><Bayesian spatial analysis><Bayesian statistical analysis><Bayesian statistical inference><Bayesian statistics><Birth><Birth Weight><Black><Black race><Blinded><Blood><Blood Reticuloendothelial System><Bone Density><Bone Development><Bone Mineral Density><Brain><Brain Nervous System><Breathing><Breathing Mechanics><Bronchial Asthma><Calciol><Caring><Certification><Child><Child Youth><Childhood><Childhood Asthma><Children (0-21)><Cholecalciferol><Chronic lung disease><Chronologic Fetal Maturity><Clinical><Clinical Research><Clinical Study><Cognition><Cognitive><Computerized Medical Record><Development><Disease><Disorder><Electronic Medical Record><Encephalon><Enrollment><Ensure><Ethnic Origin><Ethnicity><Europe><Evaluation><Family member><Feeds><Fetal Age><Foundations><Funding><Gestation><Gestational Age><Health><Health Care><Health Care Utilization><Hispanic><Hospital Admission><Hospitalization><Immune system><Infant><Infection><Intermediary Metabolism><International><Interview><Investigators><Knowledge><LC/MS><Learning><Liquid Chromatography><Low Birth Weight Infant><Lung><Lung Function Tests><Lung Respiratory System><Measures><Mechanical ventilation><Mechanics><Mentors><Mentorship><Metabolic Processes><Metabolism><Methods><Multi-center Neonatal Research Network><Multicenter Neonatal Research Network><NICHD><National Institute of Child Health and Human Development><Neonatal><Neonatal Research Network><Network Infrastructure><Neurodevelopmental Impairment><O element><O2 element><Ontario><Oscillometry><Osteopenia><Outcome><Oxygen><Parents><Parturition><Patients><Pediatric asthma><Phase><Population><Pregnancy><Premature Infant><Probability><Protocol Compliance><Pulmonary function tests><Questionnaires><Race><Races><Randomization trial><Randomized><Recommendation><Recurrence><Recurrent><Regimen><Reproducibility><Research><Research Personnel><Research Resources><Research Support><Researchers><Resources><Respiratory Aspiration><Respiratory Inspiration><Respiratory Mechanics><Running><Severity of illness><South Carolina><Speed><Structure><Subgroup><Supplementation><Supplementation with vitamin D><System><Testing><Toddler><Training><Transmission><United States><Universities><VIT D><Variant><Variation><VitD3><Vitamin D><Vitamin D 3><Vitamin D Deficiency><Vitamin D supplementation><Vitamin D3><Wheezing><Withdrawal><active followup><adulthood><age 2 years><age 6 years><age associated effects><age effect><age related effects><aged 2 years><aged two years><ages><aging effect><bone><chronic pulmonary disease><clinical practice><cost><developmental><disease severity><dosage><enroll><extreme prematurity><extremely premature infant><extremely preterm><extremely preterm infant><follow up><follow-up><followed up><followup><health care service use><health care service utilization><impact of age><improved><improved outcome><infants born premature><infants born prematurely><infection rate><influence of age><inspiration><kids><liquid chromatography mass spectrometry><low birth weight><low birthweight><lung development><lung function><male><mechanic><mechanical><mechanical respiratory assist><mechanically ventilated><mortality><neonatal period><novel><oscillography><parent><pediatric><premature baby><premature infant human><premature neonates><premature newborn><preterm baby><preterm infant><preterm infant human><preterm neonate><preterm newborn><prevent><preventing><primary outcome><pulmonary><pulmonary function><quantitative ultrasound><racial><racial background><racial origin><randomisation><randomization><randomized trial><randomly assigned><rate of infection><respiratory><secondary outcome><sex><six year old><six years of age><sound><success><tandem mass spectrometry><tibia><transmission process><trial comparing><two year old><two years of age><very premature><very preterm><vitamin D supplement><wheeze><youngster><♂>
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Hongming MA

WASHINGTON UNIVERSITY, SAINT LOUIS, MO

Exploratory lead · 10/100
Active award
$155,454
FY 2025

Project Title

Molecular Basis of Receptor Interactions for Venezuelan Equine Encephalitis

Grant Number:

1R03AI194212-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2027

Project Abstract

Project Summary Title: Molecular basis of receptor interactions for Venezuelan equine encephalitis Venezuelan Equine Encephalitis Virus (VEEV) is a mosquito-transmitted alphavirus that causes severe neurological symptoms in South and Central America and threatens parts of the southern region of the ...

Research Terms

<3-D><3-Dimensional><3D><Affinity><Alpha Virus><Americas><Amino Acid Substitution><Amino Acids><Animals><Assay><BBB crossing><Binding><Bioassay><Biological Assay><Brain Inflammation><CNS Nervous System><CRISPR><CRISPR activation><CRISPR activator><CRISPR based activation><CRISPR editing screen><CRISPR gene activation><CRISPR screen><CRISPR transcription activation><CRISPR transcriptional activation><CRISPR-Cas-9-mediated gene activation><CRISPR-based gene activation><CRISPR-based screen><CRISPR-dCAS9 Activator><CRISPR-mediated transcriptional activation><CRISPR/CAS9 activation><CRISPR/CAS9 gene activation><CRISPR/Cas system><CRISPR/Cas9 screen><CRISPR/dCas9 activation><CRISPR/dCas9-based transcriptional activation><CRISPRa><Candidate Disease Gene><Candidate Gene><Cell Body><Cell Culture Techniques><Cell Isolation><Cell Line><Cell Segregation><Cell Separation><Cell Separation Technology><Cell membrane><CellLine><Cells><Central America><Central Nervous System><Clustered Regularly Interspaced Short Palindromic Repeats><Codon><Codon Nucleotides><Cryo-electron Microscopy><Cryoelectron Microscopy><Culicidae><Cytoplasmic Membrane><DNA mutation><Data><Death Rate><Defect><Domestic Horse><Drugs><E1 protein><Ectopic Expression><Electron Cryomicroscopy><Encephalitis><Engineering><Ensure><Equine><Equine Species><Equus caballus><Equus przewalskii><Essential Amino Acids><Evolution><External Domain><Extracellular Domain><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Generations><Genes><Genetic Change><Genetic Screening><Genetic defect><Genetic mutation><Genetics-Mutagenesis><Geography><Global Warming><Glycosaminoglycans><Goals><Group A Arboviruses><HPV-16 E1 protein><HPV16 E1 protein><Horses><Human><Human papilloma virus 16 E1 protein><Human papillomavirus 16 E1 protein><In Vitro><Infection><Infection Control><Interferometry><International><Jurkat Cells><K562 Cells><Knowledge><LDL Receptors><LDLR gene><Laboratories><Left><Libraries><Licensing><Lipoprotein LDL Receptors><Lipoprotein Receptor><Low Density Lipoprotein Receptor><Mammalian Cell><Maps><Mediating><Medication><Membrane Protein Gene><Membrane Proteins><Membrane-Associated Proteins><Mice><Mice Mammals><Modern Man><Molecular><Molecular Configuration><Molecular Conformation><Molecular Interaction><Molecular Stereochemistry><Monitor><Mosquitoes><Mucopolysaccharides><Murine><Mus><Mutagenesis><Mutagenesis Molecular Biology><Mutation><N-terminal><NH2-terminal><Neuraxis><Neurologic Manifestations><Neurologic Signs and Symptoms><Neurologic Symptoms><Neurological Manifestations><Neurological Signs and Symptoms><Organ><Pathway interactions><Peripheral><Pharmaceutical Preparations><Phenotype><Plasma Membrane><Proteins><Public Health><Quality Control><Receptor Protein><Role><Route><South America><Strains Cell Lines><Structure><Surface><Surface Proteins><Testing><Therapeutic><Transmission><Travel><United States><Urbanization><VEE virus><VEEV><Vaccines><Validation><Variant><Variation><Venezuelan Equine Encephalitic Virus><Venezuelan Equine Encephalitis><Venezuelan Equine Encephalitis Virus><Venezuelan Equine Encephalomyelitis><Venezuelan Equine Encephalomyelitis Virus><Venezuelan Equine Fever><Viral Diseases><Viral Envelope Proteins><Viral Pathogenesis><Virus><Virus Diseases><Virus-like particle><access to vaccination><access to vaccines><activating CRISPR technology><aminoacid><blood-brain barrier crossing><bloodbrain barrier crossing><candidate validation><cell culture><cell cultures><cell sorting><clustered regularly interspaced short palindromic repeats screen><conformation><conformational><conformational state><conformationally><conformations><cryo-EM><cryoEM><cryogenic electron microscopy><cultured cell line><deep sequencing><design><designing><determine efficacy><disease control><disorder control><drug/agent><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><flow cytophotometry><gain of function><genome mutation><improved><in vivo><inhibitor><mortality rate><mortality ratio><mutant><mutation scanning><mutation screening><neural manifestation><novel><pathway><plasmalemma><receptor><scaffold><scaffolding><screening><screenings><social role><subcutaneous><subdermal><three dimensional><tool><transmission process><vaccination access><vaccination availability><vaccine access><vaccine availability><validations><vector mosquito><viral infection><virus infection><virus pathogenesis><virus-induced disease><virus-like nanoparticles><viruslike particle>
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Carolyn T Bramante

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 10/100
Active award
$155,000
FY 2025

Project Title

Analysis of clinical trial data to better understand Long Covid

Grant Number:

1R03TR004982-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/5/2025

End Date:

8/31/2027

Project Abstract

Project Summary Long COVID is a new chronic illness that represents an emerging public health crisis about which the medical community needs more information. The COVID-OUT trial was a phase 3, randomized, placebo-controlled clinical trial of early outpatient treatment of COVID-19 using a 2x3 factor...

Research Terms

<21+ years old><Active Follow-up><Acute><Address><Adult><Adult Human><Affect><Ambulatory Care><Behavioral><COVID-19><COVID-19 infection><COVID-19 therapy><COVID-19 treatment><COVID-19 virus infection><COVID19 infection><CV-19><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Chronic><Chronic Disease><Chronic Illness><Clinical><Clinical Trials><Communication><Communities><Conduct Clinical Trials><Coronavirus Infectious Disease 2019><Data><Data Analyses><Data Analysis><Data Bases><Data Collection><Data Set><Databases><Development><Diabetes Mellitus><Diagnosis><Dimethylbiguanidine><Dimethylguanylguanidine><Disease><Disorder><Drugs><Economics><Effectiveness><Enrollment><Equilibrium><Family><Fluoxamine><Fluvoxamine><Frequencies><Funding><Future><Home><Hypertension><Immune system><Individual><Infection><Institution><Investigators><Ivermectin><Knowledge><Literature><Long COVID><Long COVID-19><Long coronavirus disease><Long coronavirus disease 2019><Long-term Follow-up><Low income><Maps><Medical><Medication><Mental Depression><Metformin><Modeling><N,N-dimethyl-imidodicarbonimidic diamide><Newly Diagnosed><Obesity><Oral><Outcome><Outpatient Care><PASC><Participant><Pharmaceutical Preparations><Phase><Phase 3 Clinical Trials><Phase III Clinical Trials><Phenotype><Physical activity><Placebos><Post Acute Sequelae of COVID19><Post Acute Sequelae of SARS-CoV-2><Post Acute Sequelae of SARS-CoV2><Post Acute Sequelae of severe acute respiratory syndrome coronavirus 2><Post-Acute Sequelae of SARS-CoV-2 Infection><Prospective cohort><Public Health><Randomized><Recovery><Research><Research Personnel><Researchers><Risk><Risk Factors><Risk Reduction><SARS-CoV-2 infection><SARS-CoV-2 therapy><SARS-CoV-2 treatment><SARS-CoV2 infection><Sampling><Science><Severe acute respiratory syndrome coronavirus 2 infection><Severities><Sham Treatment><Sleep><Subgroup><Survey Instrument><Surveys><Symptom Burden><Symptoms><Testing><Time><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><Vaccination><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Viral Burden><Viral Load><Viral Load result><Weight><Work><active followup><acute COVID-19><acute SARS-CoV-2 infection><acute infection><acute phase of COVID-19><acute phase of SARS-CoV-2 infection><adiposity><adulthood><adverse sequelae of COVID><adverse sequelae of COVID-19><adverse sequelae of coronavirus disease><adverse sequelae of coronavirus disease 2019><balance><balance function><chronic COVID><chronic COVID-19><chronic COVID-19 sequelae><chronic disorder><chronic novel coronavirus disease 2019><clinical trial analysis><co-morbid><co-morbidity><cohort><comorbidity><computer based prediction><coronavirus disease 2019><coronavirus disease 2019 infection><coronavirus disease 2019 therapy><coronavirus disease 2019 treatment><coronavirus disease-19><coronavirus infectious disease-19><corpulence><data base><data interpretation><depression><design><designing><developmental><diabetes><disease diagnosis><drug/agent><early clinical trial><early phase clinical trial><economic><enroll><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><follow up><follow up assessment><follow-up><followed up><followup><followup assessment><high blood pressure><homes><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><improved><infected with COVID-19><infected with COVID19><infected with SARS-CoV-2><infected with SARS-CoV2><infected with coronavirus disease 2019><infected with severe acute respiratory syndrome coronavirus 2><insight><intervention arm><life-threatening COVID><life-threatening COVID-19><life-threatening SARS-CoV-2><life-threatening coronavirus disease><life-threatening coronavirus disease 2019><life-threatening severe acute respiratory syndrome coronavirus 2><long haul COVID><long haul COVID-19><long haul coronavirus disease><long haul coronavirus disease 2019><long haul sequelae of COVID-19><long haul sequelae of coronavirus disease 2019><long-hauler COVID><long-hauler COVID-19><long-hauler coronavirus disease 2019><long-hauler syndrome><long-term COVID><long-term COVID-19><long-term coronavirus disease><long-term coronavirus disease 2019><long-term followup><long-term sequelae of COVID-19><long-term sequelae of SARS-CoV-2><long-term sequelae of coronavirus disease 2019><long-term sequelae of severe acute respiratory syndrome coronavirus 2><nasal swab><outpatient treatment><pandemic><pandemic disease><persistent COVID-19><phase III protocol><post COVID syndrome><post COVID-19 sequelae><post COVID-19 syndrome><post acute COVID syndrome><post acute COVID-19><post acute COVID-19 syndrome><post acute SARS-CoV-2><post acute coronavirus disease 2019><post acute coronavirus disease 2019 syndrome><post acute coronavirus disease syndrome><post acute sequelae following COVID-19><post acute severe acute respiratory syndrome coronavirus 2><post coronavirus disease 2019 syndrome><post coronavirus disease syndrome><post-COVID><post-COVID-19><post-acute phases of COVID-19><post-acute sequelae following SARS-CoV-2 infection><post-acute sequelae of COVID-19><post-acute sequelae of acute COVID infection><post-acute sequelae of coronavirus disease 2019><post-coronavirus disease 2019><predictive modeling><prevent><preventing><primary outcome><prolonged COVID-19 symptoms><prospective><racial minority group><racial minority individual><racial minority people><racial minority population><randomisation><randomization><randomized placebo-controlled clinical trial><randomly assigned><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><respiratory virus><risk-reducing><secondary analysis><secondary outcome><serious COVID><serious COVID-19><serious SARS-CoV-2><serious coronavirus disease><serious coronavirus disease 2019><serious severe acute respiratory syndrome coronavirus 2><severe COVID><severe COVID-19><severe COVID19><severe SARS-CoV-2><severe acute respiratory syndrome coronavirus 2 therapy><severe acute respiratory syndrome coronavirus 2 treatment><severe coronavirus disease><severe coronavirus disease 19><severe coronavirus disease 2019><severe severe acute respiratory syndrome coronavirus 2><sham therapy><translational investigator><translational researcher><translational scientist><treat COVID-19><treat SARS-CoV-2><treat coronavirus disease 2019><treat severe acute respiratory syndrome coronavirus 2><treatment arm><weights>
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Lauren Elisabeth Harrison

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 10/100
Active award
$154,000
FY 2025

Project Title

Applying Service Design Methods to Enhance Implementation and Adoption of a Digital Graded Exposure Treatment for Youth with Chronic Musculoskeletal Pain in Clinical Settings

Grant Number:

1R03AR084020-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2027

Project Abstract

Abstract Chronic musculoskeletal (MSK) pain affects the lives of over a quarter of youth and impacts multiple domains of functioning, including social, emotional, and behavioral functioning. Digital behavioral health interventions offer solutions to existing access to care barriers, with outcomes si...

Research Terms

<12-20 years old><21+ years old><Acceleration><Access to Care><Address><Adolescence><Adoption><Adult><Adult Human><Affect><Android App><Android Application><Arthritis><Attention><Behavioral><Caring><Cell Phone Application><Cell phone App><Cellular Phone App><Cellular Phone Application><Childhood><Chronic><Chronology><Clinic><Clinic Visits><Clinical><Clinical Trials><Collaborations><Data Collection><Dedications><Development><Diamond><Education><Educational aspects><Effectiveness><Emotional><Ensure><Evidence based intervention><Goals><Grant><Health Care><Health Services Accessibility><Hybrids><Impairment><Internet><Intervention><Intervention Studies><Investigation><Investigators><K23 Award><K23 Mechanism><K23 Program><Living Wills><Maps><Medicine><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Methodology><Methods><Modeling><Monitor><Musculoskeletal><Musculoskeletal Diseases><Musculoskeletal Pain><NIAMS><National Institute of Arthritis, and Musculoskeletal, and Skin Diseases><Orthopedic><Orthopedic Surgical Profession><Orthopedics><Outcome><Pain Control><Pain Therapy><Pain management><Patients><Persons><Phase><Preparation><Preparedness><Prevention><Process><Proliferating><Provider><Readiness><Research><Research Personnel><Research Resources><Research Support><Researchers><Resources><Rheumatology><Science><Scientist><Services><Site><Smart Phone App><Smart Phone Application><Smartphone App><Specific qualifier value><Specified><Sports Medicine><Technology><Time><Training><Visual><Vocation><WWW><Waiting Lists><Youth><Youth 10-21><access to health services><access to services><access to treatment><accessibility to health services><adolescence (12-20)><adulthood><app on a smartphone><application on a smartphone><arthritic><availability of services><barrier to care><barrier to health care><barrier to treatment><behavioral health intervention><care access><cell phone based app><chronic MSK pain><chronic musculoskeletal pain><clinical care><clinical practice><clinical research site><clinical site><context for implementation><cost><data integration><design><designing><determine efficacy><developmental><digital><digital based behavioral intervention><digital behavioral intervention><digital health><digital health behavioral intervention><digital intervention><digital tool><digital toolkit><disability><effectiveness/implementation hybrid><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><emotional functioning><evaluate efficacy><examine efficacy><health service access><health services availability><high risk><iOS app><iOS application><iPhone App><iPhone Application><implementation context><implementation strategy><implementation/effectiveness><improved><in vivo><innovate><innovation><innovative><intervention delivery><intervention design><intervention research><interventional research><interventional study><interventions research><living will><mobile phone app><model design><musculoskeletal disorder><non-medical opioid use><nonmedical opioid use><obstacle to care><obstacle to health care><opiate misuse><opioid misuse><pain intervention><pain treatment><pediatric><phone app><phone application><preparations><programs><service availability><service utilization><smartphone application><smartphone based app><smartphone based application><social><societal costs><strategies for implementation><therapy design><timeline><tool><treatment access><treatment design><urban area><urban location><urban region><waitlist><wasting><web><world wide web><youth age>
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Bin Gu

HENRY FORD HEALTH + MICHIGAN STATE UNIVERSITY HEALTH SCIENCES, EAST LANSING, MI

Exploratory lead · 10/100
Active award
$153,278
FY 2025

Project Title

Developing a Dre-rox Recombination-Based Genetically Engineered Mouse Model (GEMM) for NUT Carcinoma

Grant Number:

1R03CA299539-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/3/2025

End Date:

6/30/2027

Project Abstract

Title: Developing a Dre-rox Recombination-Based Genetically Engineered Mouse Model (GEMM) for NUT Carcinoma. Project Summary: NUT-rearranged neoplasm is an emerging group of poorly characterized aggressive cancers caused by fusion genes, formed by chromosome translocations, involving the testis-spec...

Research Terms

<Ablation><Alleles><Allelomorphs><Animal Model><Animal Models and Related Studies><Biology><Body Tissues><Cancer Cause><Cancer Etiology><Cancer Genes><Cancer Model><Cancer-Promoting Gene><CancerModel><Cancers><Cell Body><Cell Communication and Signaling><Cell Signaling><Cells><Chromosomal dislocation><Chromosomal translocation><Clinical><Cre Lox technology><Cre LoxP system><Cre lox recombination><Cre lox recombination system><Cre lox system><Cre recombinase/LoxP technology><Cre system><DNA Recombination><Desmoplastic><Desmoplastic Reaction><Development><Disease><Disorder><E1A Enhancer-Binding Protein E1AF><E1A enhancer binding protein><E1A enhancer-binding protein F><E1A-F><E1AF><ETV4><ETV4 gene><Ectopic Expression><Ets Variant Protein 4><Event><FLP recombinase><FLP site-specific recombinase><GEM model><GEMM model><Genes><Genetic><Genetic Recombination><Genetic Translocation><Genetically Engineered Mouse><Human><Intracellular Communication and Signaling><Invaded><Investigation><Life><Lineage Tracing><LoxP-flanked allele><Malignant Neoplasms><Malignant Soft Tissue Neoplasm><Malignant Tumor><Mediating><Mice><Mice Mammals><Modeling><Modern Man><Molecular><Murine><Mus><NUT midline carcinoma><Neoplasms><Nuclear Protein><Nut carcinoma><Oncogenes><Oncogenesis><Oncogenic><PEAS3><Pathway interactions><Population><Pre-Clinical Model><Preclinical Models><Progenitor Cells><Prognosis><Recombination><Reporter><Reporting><Research Resources><Resources><Role><Sarcoma><Signal Transduction><Signal Transduction Systems><Signaling><Site><System><Technology><Testicles><Testing><Testis><Therapeutic><Time><Tissues><Transforming Genes><Undifferentiated><biological signal transduction><c myc><c-myc Genes><cancer progenitor><cancer progenitor cells><cancer stem cell><cancer stem like cell><cell lineage analysis><cell lineage mapping><cell lineage tracing><cell lineage tracking><cell type><cellular lineage mapping><cellular lineage tracking><chromosome dislocation><chromosome translocation><cmyc><conditional knock-out><conditional knockout><develop therapy><developmental><effective therapy><effective treatment><ets variant 4><floxed><floxed allele><fusion gene><gene manipulation><genetic manipulation><genetically engineered mouse model><genetically engineered murine model><genetically manipulate><genetically perturb><improved><induced Cre><inducible Cre><inhibitor><innovate><innovation><innovative><insight><intervention development><malignancy><malignant progenitor><malignant soft tissue tumor><malignant stem cell><model of animal><mutant><neoplasia><neoplasm/cancer><neoplastic growth><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><novel><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><oncogenic progenitor><oncogenic stem cells><pathway><pre-clinical><preclinical><progenitor cell pool><progenitor cell population><progenitor like cancer cell><progenitor pool><progenitor population><programs><recombinase><resilience><resilient><response to therapy><response to treatment><social role><stem and progenitor cell population><stem cell pool><stem cell population><stem cells><stem like cancer cell><success><suicide gene><therapeutic agent development><therapeutic development><therapeutic evaluation><therapeutic response><therapeutic target><therapeutic testing><therapy development><therapy response><tool><treatment development><treatment response><treatment responsiveness><tumor><tumorigenesis><v-myc Avian Myelocytomatosis Viral Oncogene Cellular Homolog>
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CHARLES LEE TURNBOUGH

UNIVERSITY OF ALABAMA AT BIRMINGHAM, BIRMINGHAM, AL

Exploratory lead · 10/100
Active award
$148,500
FY 2025

Project Title

Role of Ca2+ in B. anthracis exosporium assembly

Grant Number:

1R03AI182814-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2027

Project Abstract

PROJECT SUMMARY Bacillus anthracis is a Gram-positive soil bacterium that forms spores when starved for nutrients, and contact with these spores causes anthrax in animals and humans. B. anthracis spores are surrounded by three protective layers, the outermost of which is a loosely fitting exosporiu...

Research Terms

<Acids><Adverse effects><Aerobic><Animals><Anthrax><Anthrax disease><Anthrax spore><B anthracis><B anthracis spore><B. anthracis><B. anthracis spore><Bacillus><Bacillus anthracis><Bacillus anthracis spore><Bacteria><Bacterial Spores><Basal Layer><Binding><Binding Sites><Biochemical><Biological Terrorism><Biology><Bioterror><Bioterrorism><Cell Body><Cells><Chelating Agents><Chelators><Collagen><Combining Site><Complex><Complexons><Cryo-electron Microscopy><Cryoelectron Microscopy><DNA mutation><Development><Disease><Disorder><Dryness><EDTA><Edathamil><Edetic Acid><Electron Cryomicroscopy><Elements><Ethylenediaminetetraacetic Acid><Ethylenedinitrilotetraacetic Acid><Filament><GeneHomolog><Genetic Change><Genetic defect><Genetic mutation><Glycoproteins><Goals><Homolog><Homologous Gene><Homologue><Human><Hydrogen Oxide><In Vitro><Individual><Infection prevention><Ions><Knowledge acquisition><Medical><Methods><Mission><Modern Man><Molecular Interaction><Mothers><Mutation><NIH><Napping><National Institutes of Health><Nutrient><O element><O2 element><Outcome><Oxygen><Peripheral><Play><Position><Positioning Attribute><Prevent infection><Process><Property><Proteins><Public Health><Publishing><Pyrimidine><Reactive Site><Reproduction spores><Research><Rete Malpighii><Roentgen Rays><Role><Single Crystal Diffraction><Soil><Spores><Starvation><Stratum Basale><Stratum Germinativum><Structure><Surface><United States National Institutes of Health><Water><Weight><X Ray Crystallographies><X-Radiation><X-Ray Crystallography><X-Ray Diffraction Crystallography><X-Ray Radiation><X-Ray/Neutron Crystallography><X-ray><Xray><Xray Crystallography><anthracis><anthracis spore><chelation><cryo-EM><cryoEM><cryogenic electron microscopy><cysteine rich protein><developmental><flexibility><flexible><genome mutation><hair-like nap><human disease><in vivo><macromolecule><monomer><novel><nutrient deprivation><nutritional deprivation><paralog><paralogous gene><pathogen><protein purification><response><scaffold><scaffolding><self assembly><social role><weights>
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Tehnaz Parakh Boyle

BOSTON MEDICAL CENTER, BOSTON, MA

Exploratory lead · 10/100
Active award
$147,946
FY 2025

Project Title

Developing an assessment toolkit and training for teleconsultation as an intervention to improve prehospital patient safety in children

Grant Number:

5R03HL171172-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/22/2024

End Date:

12/31/2026

Project Abstract

PROJECT SUMMARY Children with severe respiratory and cardiopulmonary illness who need out-of-hospital (prehospital) emergency care are vulnerable to error and preventable harm. Improving prehospital patient safety for children is a national research priority. Video-consultation with pediatric expert...

Research Terms

<0-11 years old><Address><Adherence><Adoption><Agreement><Ambulances><Applied Research><Applied Science><Assessment instrument><Assessment tool><Award><Blinded><Cardiopulmonary><Cardiopulmonary Resuscitation><Caring><Cessation of life><Child><Child Care><Child Youth><Childhood><Children (0-21)><Classification><Clinical><Clinical Trials><Communication><Consensus><Consultations><Critically ill children><Data><Death><ED care><ER care><Education><Education for Intervention><Educational Intervention><Educational aspects><Effectiveness><Emergency Care><Emergency Department care><Emergency Room care><Emergency health care><Emergency medical care><Emergency medical service><Environment><Event><Feedback><Future><Goals><Harm Minimization><Harm Reduction><Heart failure><Hospitals><Human Resources><In Situ><Individual><Infrastructure><Instruction Intervention><Intervention><Investigators><Investments><K23 Award><K23 Mechanism><K23 Program><Life><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Manpower><Measurable><Measurement><Measures><Medical Directors><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Methods><Paramedic><Paramedical Personnel><Parents><Participant><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Performance><Phone><Physician Executives><Physicians><Pre-hospital care><Pre-hospital emergency care><Pre-hospitalization care><Preclinical Testing><Prehospital Emergency Care><Prehospital care><Prehospitalization care><Process><Protocol><Protocols documentation><Puericulture><QOC><Quality of Care><Radio><Randomized Controlled Clinical Trials><Randomized, Controlled Trials><Research><Research Infrastructure><Research Personnel><Research Priority><Researchers><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Safety><Scientist><Severities><Standardization><Stress><Structure><Survey Instrument><Surveys><System><Systematics><Technology><Telemedicine><Telephone><Testing><Time><Training><Training Intervention><Video Recording><Videorecording><Work><acceptability and feasibility><access gaps><cardiac failure><cardiac resuscitation><care as usual><career><clinical applicability><clinical application><cohort><consultation><cost><critically ill child><design><designing><efficacy testing><efficacy trial><emergency service><experience><feasibility testing><gaps in access><heart resuscitation><high risk><improved><improved outcome><innovate><innovation><innovative><instructional intervention><intervention arm><intervention effect><intervention refinement><kids><lung failure><mobile computing><mobile platform><mobile technology><model-based simulation><models and simulation><parent><patient oriented outcomes><patient safety><pediatric><pediatric emergency><personnel><pre-clinical testing><primary outcome><pulmonary failure><quality assurance><randomized control clinical trial><randomized control trial><remote care><remote health care><respiratory><safety outcomes><secondary analysis><service providers><simulation><skill acquisition><skill development><skills><teleconsult><teleconsultation><telehealth systems><tool><treatment arm><treatment as usual><trial comparing><under served community><underserved community><usual care><video recording system><youngster>
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Natalie Gilks Farny

WORCESTER POLYTECHNIC INSTITUTE, WORCESTER, MA

Exploratory lead · 10/100
Active award
$146,624
FY 2025

Project Title

Nucleic acid aptamers as interventions for developmental neurotoxicity

Grant Number:

1R03ES037819-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2025

End Date:

8/31/2027

Project Abstract

Lead (Pb) poisoning remains a pervasive public health problem in the U.S., causing neurotoxicity in children. Pb exposures are cumulative, and therapeutic elimination of Pb is not feasible for most affected people. Thus, prophylactic strategies are essential for protecting the health of exposed chil...

Research Terms

<0-11 years old><Address><Affect><Alimentary Canal><Animals><Assay><Awareness><Behavior><Behavioral><Binding><Bioassay><Biological Assay><C elegans><C. elegans><C.elegans><Caenorhabditis elegans><Calcium><Chelation Therapy><Child><Child Youth><Children (0-21)><Communities><Complex><DA Neuron><DNA><Deoxyribonucleic Acid><Deposit><Deposition><Digestive Tract><Dopamine neuron><Dose><Drugs><Dust><EDTA><Edathamil><Edetic Acid><Environment><Environmental Hazards><Ethylenediaminetetraacetic Acid><Ethylenedinitrilotetraacetic Acid><Exposure to><Exposure to Pb2+><Fluorescence Light Microscopy><Fluorescence Microscopy><Food><G-Quadruplex><G-Quadruplexes DNA><G-Quartet Structures><G-Quartets><G-Tetrads><G4-DNA><GI Tract><Gastrointestinal Tract><Gastrointestinal tract structure><Goals><Health><Health protection><Heavy Metals><Human><Hydrogen Oxide><Image><Individual><Ingestion><Intervention><Ions><Lead><Lead Poisoning><Lead levels><Measures><Medication><Metals><Methods><Modeling><Modern Man><Molecular Interaction><Morphology><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurologic Effect><Neurons><Non-Polyadenylated RNA><Nucleic Acids><Nucleotides><Oral><Organism><Paint><Pb element><Pb exposed><Pb exposure><Pb lead toxicity><Pb levels><Pb poisoning><Pb toxic effect><Pb toxicity><Pb2+ Exposure><Pb2+ Toxicity><Pb2+ exposed><Pb2+ lead toxicity><Pb2+ poisoning><Pb2+ toxic effect><Persons><Pharmaceutical Preparations><Phenotype><Poisoning><Preventative strategy><Prevention><Prevention strategy><Preventive strategy><Public Health><Publishing><RNA><RNA Gene Products><Reporter><Reporting><Research><Ribonucleic Acid><Role><Safety><Single-Stranded DNA><Source><Spectroscopy><Spectrum Analyses><Spectrum Analysis><Stretching><Structure><System><Technology><Therapeutic><Toxic effect><Toxicities><Transgenic Organisms><Water><Work><absorption><alimentary tract><aptamer><behavior phenotype><behavioral phenotyping><blood Pb><blood lead><bone><burden of disease><burden of illness><chelation><cost effective><developmental neurotoxicity><digestive canal><disease burden><dopaminergic neuron><drug/agent><exposed to lead><exposure to Pb><exposure to lead><heavy metal Pb><heavy metal lead><high risk><imaging><in vivo><ingest><innovate><innovation><innovative><intravenous administration><kids><lead exposed><lead exposure><lead in blood><lead level><lead poisonings><lead toxic effect><lead toxicity><level of lead><life span><lifespan><living system><model organism><neuron toxicity><neuronal><neuronal toxicity><neurotoxic><neurotoxicity><poisoned><prevent><preventing><prophylactic><reproductive><response><safety testing><small molecule><social role><ssDNA><standard care><standard treatment><toxic effect to lead><toxic metal><toxicity to lead><transgenic><youngster>
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Guilherme Manna Cesar

UNIVERSITY OF NORTH FLORIDA, JACKSONVILLE, FL

Exploratory lead · 10/100
Active award
$141,804
FY 2024

Project Title

Biomechanical Changes Underpinning Stand-on Ride-on Power Mobility Devices for Children with Cerebral Palsy

Grant Number:

1R03HD114548-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

5/31/2026

Project Abstract

Project Summary Children’s participation in life activities with family and peers plays a vital role in their physical and psychosocial development. Many children with cerebral palsy are often deprived of such interactions given limited postural control and walking capabilities, leading to delayed ...

Research Terms

<0-11 years old><Address><Age><Applications Grants><Area><Attention><Biomechanics><Case Series><Case Study><Cerebral Palsy><Characteristics><Child><Child Youth><Children (0-21)><Classification><Clinical Research><Clinical Study><Coupling><Data><Decline in mobility><Decrease in mobility><Decreased mobility><Development><Devices><Diminished mobility><Early Intervention><Equilibrium><Extremities><Family><Fostering><Gait><Gastrocnemius Muscle><Goals><Grant Proposals><Health><Individual><Individuals with physical disabilities><Injury><Intervention><Intervention Strategies><Kinetics><Knowledge><Life><Limb structure><Limbs><Literature><Lower Extremity><Lower Limb><Measures><Medical><Medical center><Membrum inferius><Mobility decline><Mobility impairment><Modification><Motor><Motor disability><Movement><Muscle><Muscle Tissue><Musculoskeletal Equilibrium><NICHD><NIH><NINDS><National Institute of Child Health and Human Development><National Institute of Children's Health and Human Development><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Neurologic><Neurological><Non-Trunk><Outcome><Pattern><Pelvic><Pelvic Region><Pelvis><Persons with Physical Disabilities><Physical activity><Play><Population><Postural Balance><Postural Equilibrium><Posture><Prepuberal state><Public Health><QOL><Quality of life><Reaction><Recommendation><Reduced mobility><Reduction in mobility><Research><Research Priority><Role><Sampling><Socialization><Societies><Strategic Planning><Structure><System><Systematics><Technology><Testing><Time><United States National Institutes of Health><Walking><Weight><Work><active control><ages><balance><balance disorder><balance function><balance impairment><balance testing><biomechanical><body movement><case report><cohort><developmental><disturbed balance><equilibration disorder><equilibrium disorder><falls><functional outcomes><gastrocnemius><improved><injuries><interventional strategy><kids><kinematic model><kinematics><mobility aid><mobility device><muscular><novel><peer><physical disability><physically disabled><physically handicapped><post intervention><postural control><prepubertal><prepuberty><pressure><psychosocial development><quadriceps><quadriceps muscle><recruit><rehab research><rehabilitation research><social role><spatiotemporal><weights><youngster>
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Titilayo Omolara Ilori

BOSTON MEDICAL CENTER, BOSTON, MA

Exploratory lead · 10/100
Active award
$133,500
FY 2025

Project Title

ApolipoproteinL1 Genotypes and Biomarkers of Immune Activation and Tubular Injury

Grant Number:

5R03DK140290-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY Chronic Kidney Disease (CKD) can effectively be a death sentence in sub-Saharan Africa where <2% of patients with kidney failure have access to dialysis or transplantation. Biomarkers of immune activation (soluble tumor necrosis factor receptor 1 [sTNFR1], tumor necrosis factor alpha...

Research Terms

<(IFN) α><(IFN)-α><(IFN)α><(TNF)-α><Acceleration><Active Follow-up><Affect><Africa><Africa South of the Sahara><African><African American group><African American individual><African American people><African American population><African Americans><African ancestry><African descent><Alferon><Aliquot><Ancillary Study><Apolipoproteins><Biological Markers><Black Populations><Black group><Black individual><Black people><Blacks><Blood Plasma><Blood Serum><CD 120a Antigen><CD120a Antigens><Cachectin><Cell Body><Cells><Cessation of life><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical><Clinical Data><Creatinine><Data><Death><Demographic Factors><Development><Dialysis><Dialysis procedure><Diet><Disease Progression><ESKD><ESRD><Early identification><Elements><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Endothelial Cells><Enrollment><Funding><Future><Genes><Genotype><Ghana><Glomerular Filtration Rate><Gold Coast><Health><Hereditary><Human><Hypertension><IFN Alpha><IFN α><IFN-α><IFNa><IFNα><Immune Cell Activation><Immune Markers><Immunologic Markers><In Vitro><Incidence><Individual><Inflammation><Inherited><Injury><Innate Immunity><Interferon Alfa-n3><Interferon-α><Kidney><Kidney Diseases><Kidney Failure><Kidney Grafting><Kidney Insufficiency><Kidney Transplantation><Kidney Transplants><Kidney Urinary System><Leukocyte Interferon><Life><Lymphoblast Interferon><Lymphoblastoid Interferon><Macrophage-Derived TNF><Measurement><Measures><Mediating><Modern Man><Monocyte-Derived TNF><Native Immunity><Natural Immunity><Nephropathy><Nigeria><Non-Specific Immunity><Nonspecific Immunity><Participant><Pathway interactions><Patients><Persons><Phenotype><Plasma><Plasma Serum><Prospective cohort><Proteins><Renal Disease><Renal Failure><Renal Grafting><Renal Insufficiency><Renal Transplantation><Renal Transplants><Renal function><Research><Reticuloendothelial System, Serum, Plasma><Risk><Risk-associated variant><Role><Sample Size><Sampling><Serum><Sub-Saharan Africa><Subsaharan Africa><TNF><TNF A><TNF Alpha><TNF Receptor p55><TNF gene><TNF-sR55><TNF-α><TNF-α receptor><TNFA><TNFAR><TNFR p60><TNFR, 55-kD><TNFR, 60-kD><TNFR-Fc fusion protein><TNFR-I><TNFR1><TNFR55><TNFR60><TNFRSF1A><TNFRSF1A Receptor><TNFRSF1A gene><TNFalpha receptor><TNFα><TNFα receptor><TNR-001><TNT receptor fusion protein><TNTR-Fc><Testing><Time><Transplantation><Tubular><Tubular formation><Tumor Necrosis Factor><Tumor Necrosis Factor Receptor 1><Tumor Necrosis Factor Receptor 55><Tumor Necrosis Factor-alpha><U-PA receptor><Urine><Urokinase Plasminogen Activator Receptor><Urokinase Receptor><Urokinase-type Plasminogen Activator Receptor><Variant><Variation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Visceral Epithelial Cell><West African><active followup><bio-markers><biologic marker><biomarker><chronic kidney disease><cohort><developmental><dialysis therapy><diets><enroll><evidence base><follow up><follow-up><followed up><followup><gene interaction><genomic biomarker><genomic data><genomic dataset><genomic marker><glomerular visceral epithelial cell><high blood pressure><high risk><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immune activation><immune-based biomarkers><immunological biomarkers><immunological markers><in vivo><inflammation marker><inflammatory marker><injuries><kidney disorder><kidney function><kidney injury molecule 1><kidney tx><novel><pathway><podocyte><precision medicine><precision-based medicine><pro-urokinase receptor><prognostic significance><rat KIM-1 protein><recruit><renal><renal KIM-1><renal disorder><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><social role><soluble tumor necrosis factor receptor><transplant><tumor necrosis factor alpha receptor><tumor necrosis factor receptor 1A><tumor necrosis factor α receptor><uPAR receptor><urinary>
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Bradley Wertheim

BRIGHAM AND WOMEN'S HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Active award
$131,485
FY 2025

Project Title

Endothelial Proline Utilization in Pulmonary Arterial Hypertension

Grant Number:

5R03HL172985-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT Pulmonary arterial hypertension (PAH) is characterized by inflammation, endothelial dysfunction, and metabolic dysregulation, which promote fibroproliferative pulmonary arterial remodeling, right ventricular failure (RV), and early death despite current PAH therapies. Mild p...

Research Terms

<4 Hydroxyproline><Arteries><Assay><Basal Transcription Factor><Basal transcription factor genes><Binding><Bioassay><Bioavailability><Biological Assay><Biological Availability><Biomass><C-terminal Src kinase><CSK Protein Kinase><CSK-src><Catabolism><Cell Body><Cell Communication and Signaling><Cell Growth in Number><Cell Multiplication><Cell Proliferation><Cell Signaling><Cell membrane><Cell-Extracellular Matrix><Cells><Cellular Proliferation><Cessation of life><Chimera><Chimera organism><Clinical><Collagen><Collagen Fibril><Common Rat Strains><Complement><Complement Proteins><Coupling><Cytoplasmic Membrane><Data><Death><Dependence><Deposit><Deposition><Development><Dysfunction><ECM><Endothelium><Exposure to><Extracellular Matrix><Fibrosis><Functional disorder><Future><General Transcription Factor Gene><General Transcription Factors><Generalized Growth><Genes><Goals><Growth><HPLC><Heart failure><High Performance Liquid Chromatography><High Pressure Liquid Chromatography><High Speed Liquid Chromatography><Histologic><Histologically><Histology><Human><Hydroxyproline><Hypoxia><Hypoxic><Immunoblotting><Immunofluorescence><Immunofluorescence Immunologic><Immunofluorescence Microscopy><Impairment><In Vitro><Inflammation><Inflammatory><Intermediary Metabolism><Intracellular Communication and Signaling><Isotopes><Kinases><L-Proline><L-proline permease><Label><Link><Lung><Lung Respiratory System><Measures><Medicine><Membrane><Metabolic><Metabolic Processes><Metabolism><Modeling><Modern Man><Molecular><Molecular Interaction><Monocrotaline><Network Analysis><Oncogene Products><Oncogene Proteins><Oncoproteins><Ontology><Oxygen Deficiency><Oxyproline><Pathway Analysis><Pathway interactions><Pattern><Phenotype><Phosphorylation><Phosphotransferase Gene><Phosphotransferases><Physiologic Availability><Physiopathology><Plasma Membrane><Progressive Disease><Proline><Protein Phosphorylation><Protein-Tyrosine Kinase CYL><Proteins><Pulmonary Artery><Pulmonary Hypertension><Pulmonary Vascular Resistance><Pulmonary arterial remodeling><Pulmonary artery structure><Rat><Rats Mammals><Rattus><Regulation><Research Resources><Resources><Right Ventricular Dysfunction><Right heart dysfunction><Right ventricle dysfunction><Right-sided heart dysfunction><Sampling><Shortness of Breath><Signal Transduction><Signal Transduction Systems><Signaling><Supporting Cell><Systems Biology><Systolic Pressure><Testing><Tissue Growth><Tracer><Transcription Factor Proto-Oncogene><Transcription factor genes><Transphosphorylases><Tyrosine><Tyrosine-Protein Kinase CSK><Vascular Diseases><Vascular Disorder><Vasodilating Agent><Vasodilator Agents><Vasodilator Drugs><Vasodilators><Western Blotting><Western Immunoblotting><amino acid metabolism><biological signal transduction><blood vessel disorder><c-src Kinase><c-src Tyrosine Kinase><cancer cell metabolism><cancer metabolism><carboxy-terminal Src kinase><cardiac failure><career development><chimeras><complementation><developmental><distal pulmonary artery remodeling><endothelial dysfunction><glucose metabolism><glucose uptake><human interactome><imaging mass spectrometry><impaired pulmonary vascularization><in silico><in vivo><in vivo Model><inhibitor><knock-down><knockdown><lung arterial remodeling><lung vascular disease><mass spectrometric imaging><membrane structure><metabolic phenotype><metabotype><mortality><novel><ontogeny><overexpress><overexpression><pathophysiology><pathway><plasmalemma><pre-clinical><preclinical><prevent><preventing><proline permease><proline porter><proline transporter><protein blotting><protein-tyrosine kinase C-terminal Src kinase><protein-tyrosine kinase c-src><pulmonary><pulmonary arterial endothelial cell><pulmonary arterial hypertension><pulmonary arterioles remodeling><pulmonary artery endothelial cell><pulmonary artery hypertension><pulmonary artery remodeling><pulmonary vascular disease><pulmonary vascular disorder><pulmonary vascular dysfunction><pulmonary vasculopathy><recruit><right heart failure><right sided heart failure><right ventricle failure><right ventricular failure><right ventricular heart failure><small pulmonary artery remodeling><src Kinases><src Protein-Tyrosine Kinases><src Tyrosine Kinases><src-Family Kinases><src-Family Tyrosine Kinases><stable isotope><transcription factor><transcriptomics><tumor cell metabolism><tumor metabolism><uptake><vascular dysfunction><vasculopathy>
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Elwali Ahmed

MARIAN UNIVERSITY, INDIANAPOLIS, IN

Exploratory lead · 10/100
Active award
$130,600
FY 2025

Project Title

Advancing Wakefulness Screening of Sleep Apnea Disorder through Breathing Sound Analysis and Hardware Optimization

Grant Number:

1R03EB037909-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/4/2025

End Date:

7/31/2027

Project Abstract

Project Summary/Abstract Sleep apnea affects over one billion people worldwide, with obstructive sleep apnea (OSA) accounting for more than 85% of cases. OSA is characterized by repeated episodes of airway obstruction during sleep, leading to fragmented sleep and reduced oxygen levels. OSA is linked...

Research Terms

<Accounting><Acoustics><Address><Adoption><Affect><Algorithmic Software><Algorithmic Tools><Algorithms><Anesthesia><Anesthesia procedures><Apnea><Breathing Sounds><Cardiovascular Diseases><Cell Communication and Signaling><Cell Signaling><Characteristics><Classification><Clinical><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Custom><Data><Data Set><Development><Devices><Diabetes Mellitus><Diagnosis><Diagnostic><Disease><Disorder><Disturbance in cognition><Early Diagnosis><Early Intervention><Early treatment><Ensure><Environment><Foundations><Frequencies><Funding Mechanisms><Future><Goals><Health><Health Care Costs><Health Costs><Impaired cognition><Intracellular Communication and Signaling><Investigation><Link><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Lung Sounds><Machine Learning><Methods><Modeling><Noise><O element><O2 element><Obstructive Sleep Apnea><Operative Procedures><Operative Surgical Procedures><Outcome><Oxygen><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pattern><Performance><Persons><Polysomnography><Population><Prevalence><Primary Care><Process><Public Health><Questionnaires><Reporting><Research><Research Resources><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Resources><Respiratory Sounds><Risk><Rural><Screening procedure><Signal Transduction><Signal Transduction Systems><Signaling><Sleep><Sleep Apnea><Sleep Apnea Syndromes><Sleep Fragmentations><Sleep Hypopnea><Sleep Monitoring><Sleep-Disordered Breathing><Software Algorithm><Somnography><Specificity><Statistical Data Analyses><Statistical Data Analysis><Statistical Data Interpretation><Surgical><Surgical Interventions><Surgical Procedure><Syndrome, Sleep Apnea, Obstructive><Systematics><Techniques><Testing><Time><Underserved Population><Unnecessary Surgery><Validation><Wakefulness><airflow limitation><airflow obstruction><airway limitation><airway obstruction><biological signal transduction><cardiovascular disorder><clinical implementation><cognitive dysfunction><cognitive loss><cost><cost effective><customs><developmental><diabetes><early detection><early therapy><health care burden><implementation tool><improved><improvement on sleep><indexing><insight><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><microphone><novel><obstructed airflow><obstructed airway><patient oriented outcomes><portability><prediction algorithm><predictive tools><prevent><preventing><prototype><quality of sleep><respiratory airway obstruction><risk minimization><screening><screening tools><screenings><signal processing><sleep improvement><sleep measurement><sleep polysomnography><sleep quality><sleep-related breathing disorder><sound><statistical analysis><success><surgery><tool><treatment planning><under served group><under served individual><under served people><under served population><underserved group><underserved individual><underserved people><usability><user-friendly><validations>
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Jonathan Wayne Lowery

MARIAN UNIVERSITY, INDIANAPOLIS, IN

Exploratory lead · 10/100
Active award
$130,600
FY 2024

Project Title

NMUR2 in bone formation

Grant Number:

1R03AG081947-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2024

End Date:

4/30/2027

Project Abstract

Project Summary The long-term goal of this project is to establish the molecular pathway used by Neuromedin-U (NMU) in the negative regulation of bone formation. This is significant since studies in mice indicate NMU negatively regulates bone formation in vivo, making the NMU pathway a potential the...

Research Terms

<Address><Affect><Age><American><Apoplexy><Award><Bone Formation><Brain Vascular Accident><Breast Cancer><Cardiac infarction><Cell Communication and Signaling><Cell Signaling><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Stroke><Cessation of life><Chronic><Coupled><Data><Death><Disease><Disorder><FK506 Binding Protein 12-Rapamycin Associated Protein 1><FKBP12 Rapamycin Complex Associated Protein 1><FRAP1><FRAP1 gene><FRAP2><Female><Foundations><Fracture due to osteoporosis><Funding Mechanisms><Future><Goals><Histologic><Histologically><Histology><Hospital Admission><Hospitalization><Hypothalamic structure><Hypothalamus><Impairment><In Vitro><Individual><Intracellular Communication and Signaling><Investigation><KO mice><Knock-out Mice><Knockout Mice><Malignant Breast Neoplasm><Mechanistic Target of Rapamycin><Mediating><Medical Care Costs><Mice><Mice Mammals><Molecular><Murine><Mus><Myocardial Infarct><Myocardial Infarction><NIH><Names><National Institutes of Health><Neuromedin U><Neuromedin U-25><Null Mouse><Osteoblasts><Osteogenesis><Osteoporosis><Osteoporosis with fracture><Osteoporotic fracture><Pathway interactions><Proteins><RAFT1><Receptor Protein><Regulation><Reporting><Research><Research Resources><Resources><Role><Serum Markers><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Signaling Molecule><Skeleton><Stroke><Testing><Time><Translational Research><Translational Science><Uncertainty><United States National Institutes of Health><Work><ages><biological signal transduction><bone><bone mass><bone tissue formation><bone turnover><brain attack><cardiac infarct><cerebral vascular accident><cerebrovascular accident><conditional knock-out><conditional knockout><coronary attack><coronary infarct><coronary infarction><cost><disability><doubt><fracture risk><heart attack><heart infarct><heart infarction><hypothalamic><in vivo><inhibitor><interest><knock-down><knockdown><mTOR><male><malignant breast tumor><mammalian target of rapamycin><medical costs><medical expenses><name><named><naming><neuromedin U receptor><neutralizing antibody><new approaches><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic approach><new therapeutic intervention><new therapeutic strategies><new therapeutic target><new therapeutics><new therapy><new therapy approaches><new therapy target><new treatment approach><new treatment strategy><next generation therapeutics><novel><novel approaches><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel strategies><novel strategy><novel therapeutic approach><novel therapeutic intervention><novel therapeutic strategies><novel therapeutic target><novel therapeutics><novel therapy><novel therapy approach><novel therapy target><osteoblast cell differentiation><osteoblast differentiation><osteoblastic differentiation><osteoporosis associated fracture><osteoporosis related fracture><osteoporosis with pathological fracture><pathway><pharmacologic><primary end point><primary endpoint><receptor><skeletons><small molecular inhibitor><small molecule><small molecule inhibitor><social role><stroked><strokes><therapeutic target><translation research><translational investigation><translational opportunities><translational potential>
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Gina L. Tripicchio

TEMPLE UNIV OF THE COMMONWEALTH, PHILADELPHIA, PA

Exploratory lead · 10/100
Active award
$124,718
FY 2025

Project Title

Biomarker Assessment of Adherence and Effectiveness in a Randomized Controlled Trial to Reduce Added Sugar Intake in Adolescents

Grant Number:

5R03HL171171-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/16/2024

End Date:

5/31/2027

Project Abstract

PROJECT ABSTRACT Added sugar (AS) is a critically important dietary target for intervention in adolescents; it contains excess calories with no nutritional value and is independently associated with chronic disease risk. Adolescents consume more AS than any other age group and are at a unique phase ...

Research Terms

<21+ years old><Address><Adherence><Adolescent><Adolescent Youth><Adult><Adult Human><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Behavioral trial><Belief><Biological Markers><Blood><Blood Reticuloendothelial System><Calories><Canes><Carbon><Carbon Isotopes><Chronic Disease><Chronic Illness><Collection><Conditioning Therapy><Consumption><Data><Development><Diet><Diet Habits><Dietary Assessment><Dietary Habits><Dietary Intervention><Dietary intake><Ecological momentary assessment><Education><Educational aspects><Effectiveness><Effectiveness of Interventions><Enhancement Technology><Fasting><Fructose><Future><Goals><Hair><Health><Hour><Intake><Intervention><Intervention Trial><Interventional trial><Investigation><Length><Levulose><Life Cycle><Life Cycle Stages><Maps><Measures><Methodology><Methods><Nutrient><Nutrition><Nutrition Interventions><Nutritional><Nutritional Interventions><Outcome Assessment><Participant><Patient Self-Report><Phase><Philadelphia><Population><Predisposition><Preparation><Randomized><Randomized, Controlled Trials><Religion><Reporting><Research><Risk><Sample Size><Sampling><Science><Self-Report><Social Desirabilities><Social Desirability><Source><Survey Instrument><Surveys><Susceptibility><Testing><Text Messaging><Time><Unhealthy Diet><Variant><Variation><Walking Sticks><Weight><Work><Youth><Youth 10-21><adulthood><age group><behavior intervention><behavioral intervention><bio-markers><biologic marker><biomarker><chronic disorder><comparative><design><designing><developmental><diet education><diet intervention><dietary><diets><disease risk><disorder risk><disparity in health><eating habit><effective intervention><ethnic diversity><ethnically diverse><fasted><fasts><feeding><health disparity><improved><innovate><innovation><innovative><insight><intervention participants><juvenile><juvenile human><life course><novel><nutrition education><nutritious><poor diet><preparations><racial diversity><racially diverse><randomisation><randomization><randomized control trial><randomly assigned><religious><response><short message service><sms messaging><stable isotope><sugar><sweetened beverage><texting><tool><weights><youth age>
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Dusan Hanidziar

MASSACHUSETTS GENERAL HOSPITAL, BOSTON, MA

Exploratory lead · 10/100
Active award
$124,536
FY 2025

Project Title

Protective role of B cells in hyperoxic lung injury

Grant Number:

5R03HL171347-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2026

Project Abstract

High concentrations of inspired oxygen are necessary during treatment of critically ill patients with impaired lung function, such as those with acute respiratory distress syndrome (ARDS). However, studies in animal models show that hyperoxia may further exacerbate pulmonary inflammation and compoun...

Research Terms

<ARDS><Acute Lung Injury><Acute Pulmonary Injury><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Address><Adopted><Adoptive Transfer><Adult ARDS><Adult RDS><Adult Respiratory Distress Syndrome><Alveolar><Animal Model><Animal Models and Related Studies><Anti-Inflammatories><Anti-Inflammatory Agents><Anti-inflammatory><Award><B blood cells><B cell><B cell depletion therapy><B cell directed therapy><B cell receptor><B cell targeted therapy><B cell therapies><B cell therapy><B cells><B-Cell Antigen Receptor><B-Cell Subsets><B-Cells><B-Lymphocyte Subsets><B-Lymphocytes><B-cell><B220><Blood><Blood Neutrophil><Blood Plasma Cell><Blood Polymorphonuclear Neutrophil><Blood Reticuloendothelial System><Body Tissues><Brain Trauma><C57BL/6 Mouse><CD45><COVID-19><CSIF><CSIF-10><CV-19><Cardiac infarction><Cell Body><Cell Communication><Cell Count><Cell Death><Cell Interaction><Cell Number><Cell-to-Cell Interaction><Cells><Cellular immunotherapy><Clinical><Coronavirus Infectious Disease 2019><Critical Illness><Critically Ill><Cytokine Synthesis Inhibitory Factor><Cytometry><Da Nang Lung><Data><Diffuse><Ensure><Exposure to><Funding><GP180><Histology><Hour><Hyperoxia><IL-10><IL10><IL10A><Immune><Immune Globulins><Immune Regulators><Immune infiltrates><Immune mediated therapy><Immune response><Immunes><Immunoglobulins><Immunologically Directed Therapy><Immunomodulation><Immunomodulators><Immunotherapy><Impairment><Infiltration><Inflammation><Inflammatory><Injury><Interleukin 10 Precursor><Interleukin-10><Investigation><Investigators><LY5><Link><Lung><Lung Inflammation><Lung Respiratory System><Lung damage><MOPA><Marrow Neutrophil><Mediating><Mediator><Memory><Mice><Mice Mammals><Modeling><Murine><Mus><Myocardial Infarct><Myocardial Infarction><NK T cell><NKT cell><Natural Killer T cell><Neutrophil Infiltration><Neutrophil Recruitment><Neutrophilic Granulocyte><Neutrophilic Infiltrate><Neutrophilic Leukocyte><O element><O2 element><Oxygen><PTPRC><PTPRC gene><Pathogenicity><Pathway interactions><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Phenotype><Plasma Cells><Plasmacytes><Pneumonia><Pneumonitis><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Process><Production><Proliferating><Pulmonary Inflammation><Receptor Signaling><Reporting><Research><Research Personnel><Researchers><Role><Severities><Shock Lung><Site><Spleen><Spleen Reticuloendothelial System><Stiff lung><Supplementation><T200><Testing><Therapeutic><Tissues><Traumatic Brain Injury><cardiac infarct><cell-based immunotherapy><coronary attack><coronary infarct><coronary infarction><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><cytokine><diabetic><effective therapy><effective treatment><healing><heart attack><heart infarct><heart infarction><host response><hyperoxygenation><immune cell infiltrate><immune cell therapy><immune modulation><immune modulators><immune regulation><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunologic reactivity control><immunomodulatory><immunomodulatory molecules><immunoregulation><immunoregulator><immunoregulatory><immunoregulatory molecules><immunoresponse><improved><in vivo><individuals with sepsis><inhibitor><injuries><injury to organs><lung function><lung injury><lysophosphatidic acid><migration><model of animal><monooleylphosphatidate><monooleylphosphatidic acid><mouse model><murine model><natural killer T lymphocyte><necrocytosis><neutrophil><novel><organ injury><pathway><patient oriented outcomes><patients with sepsis><people with sepsis><plasmocyte><preservation><protective effect><pulmonary><pulmonary damage><pulmonary function><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><response><sepsis groups><sepsis patients><sepsis population><sepsis subjects><septic group><septic individuals><septic patients><septic people><septic population><septic subject><skin ulcer><social role><subjects with sepsis><traumatic brain damage><ulcerative wounds><wet lung>
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Tze-Woei Tan

UNIVERSITY OF SOUTHERN CALIFORNIA, Los Angeles, CA

Exploratory lead · 10/100
Active award
$124,500
FY 2025

Project Title

Evaluating the Feasibility and Acceptability of a Lifestyle Intervention to Prevent Recurrence of Diabetic Foot Ulcers: A Pilot Study

Grant Number:

5R03DK140420-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

6/30/2027

Project Abstract

ABSTRACT In the United States, millions of individuals with diabetes suffer from diabetic foot ulcers (DFUs) that negatively impact physical function, reduce quality of life, increase the risk of amputation, and drive up healthcare utilization and costs. These ulcers frequently recur after healing, ...

Research Terms

<Address><Adherence><Affect><Amputation><Area><Caring><Cessation of life><Charcot foot><Clinical><Complications of Diabetes Mellitus><Control Groups><Coping Skills><Data><Death><Development><Diabetes Complications><Diabetes Mellitus><Diabetes-Related Complications><Diabetic Complications><Diabetic Foot><Diabetic Foot Ulcer><Direct Costs><Dropout><Education><Educational aspects><Effectiveness><Enrollment><Evaluation><Extremities><Feasibility Studies><Focus Groups><Goals><Habits><Health><Health Care Utilization><Hispanic><History><Individual><Intervention><Interview><Investigators><Jobs><K23 Award><K23 Mechanism><K23 Program><Knowledge><Life Style><Lifestyle><Limb Salvage><Limb structure><Limbs><Lower Extremity><Lower Limb><Measures><Membrum inferius><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Methods><Neuropathy><Non-Trunk><Occupational Therapist><Occupational Therapy><Occupations><Outcome><Outcome Measure><Participant><Patient Outcomes Assessments><Patient Reported Measures><Patient Reported Outcomes><Patients><Persons><Phone><Physical Function><Pilot Projects><Play><Population Heterogeneity><Prevention><Professional Positions><Provider><QOL><QOL improvement><Quality of life><Randomized><Randomized, Controlled Trials><Recommendation><Recording of previous events><Recurrence><Recurrent><Research Personnel><Research Resources><Researchers><Resources><Risk><Role><Schedule><Self Care><Societies><Survey Instrument><Surveys><System><Telephone><Therapeutic><Therapeutic Intervention><Ulcer><Ulceration><United States><Visit><Walking><academic pathway><academic standard><acceptability and feasibility><assessing cost effectiveness><behavioral health><care costs><coping strategy><cost-effectiveness evaluation><death risk><determine cost effectiveness><developmental><diabetes><diabetes distress><diabetic><diabetic foot wound><disability><diverse populations><educational standard><enroll><environmental adaptation><evaluate cost-effectiveness><examine cost effectiveness><experience><foot><group intervention><healing><health care service use><health care service utilization><health related quality of life><heterogeneous population><high risk><high risk group><high risk individual><high risk people><high risk population><histories><improved><improvements in QOL><improvements in quality of life><innovate><innovation><innovative><interdisciplinary collaboration><intervention therapy><life style intervention><life-time risk><lifestyle intervention><lifetime risk><measurable outcome><mortality risk><neuropathic><outcome measurement><participant interview><patient centered><patient oriented><patient population><personal care><physical impairment><pilot study><population diversity><pressure><prevent><preventing><psychosocial><quality of life improvement><randomisation><randomization><randomized control trial><randomized, clinical trials><randomly assigned><recurrence prevention><retention rate><retention strategy><routine care><satisfaction><social role><transdisciplinary collaboration>
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Katherine Naime Balantekin

STATE UNIVERSITY OF NEW YORK AT BUFFALO, AMHERST, NY

Exploratory lead · 10/100
Active award
$120,750
FY 2025

Project Title

Positive food parenting intervention to promote healthy growth in children at risk for obesity

Grant Number:

5R03DK138232-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

6/30/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT Given our obesogenic environment with abundant access to energy-dense foods, parents often feel lost about how to help their kids make healthy food choices. This can lead to overly restrictive food parenting practices that can have negative consequences on child eating and w...

Research Terms

<0-11 years old><11 year old><11 years of age><6-11 years old><Acceleration><Age><Area><BMI><BMI percentile><BMI z-score><Behavior><Behavior assessment><Body mass index><Calories><Calories-dense food><Cell Communication and Signaling><Cell Signaling><Child><Child Rearing><Child Youth><Children (0-21)><Competence><Consumption><Curriculum><Data><Development><Dietary quality><Disease><Disorder><Eating><Eating Behavior><Educational Curriculum><Energy-dense food><Enrollment><Environment><Family><Feedback><Food><Food Intake><Food Preferences><Future><Generalized Growth><Goals><Grant><Gravitation><Growth><Health><Health Food><Healthy Eating><Individual><Intervention><Intracellular Communication and Signaling><Laboratories><Lead><Literature><Measures><Monitor><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Nutritious food><Obesity><Only Child><Outcome><Over weight><Overweight><Parenting><Parenting behavior><Parents><Participant><Pb element><Preventative intervention><Process><Public Health><Quetelet index><Randomized, Controlled Trials><Reporting><Research><Risk Reduction><Signal Transduction><Signal Transduction Systems><Signaling><Strategic Planning><Structure><Survey Instrument><Surveys><Testing><Time><Tissue Growth><Training><Treatment Efficacy><Waiting Lists><Weight><Work><acceptability and feasibility><adiposity><age 11 years><age group><ages><behavior change><behavioral assessment><biological signal transduction><caloric dense food><calorically-dense meal><calorie rich food><calorie rich meal><child adiposity><child obesity><childhood adiposity><childhood obesity><childrearing><cooking><coping><corpulence><design><designing><developmental><diet choice><diet preference><diet quality><dietary choice><dietary preferences><early childhood><efficacy testing><efficacy trial><eleven year old><eleven years of age><energy rich food><enroll><evidence base><feeding><food choice><healthy food><healthy weight><heavy metal Pb><heavy metal lead><improved><interest><intervention design><intervention efficacy><intervention for prevention><kids><lesson plans><middle childhood><novel><obese children><obesigenic><obesity during childhood><obesity in children><obesity intervention><obesity prevention><obesity risk><obesity therapy><obesity treatment><obesogenic><ontogeny><parent><parenting education intervention><parenting education programs><parenting intervention><parenting program><parenting skill training><parenting training><pediatric obesity><prevent><prevent obesity><preventing><prevention intervention><preventional intervention strategy><preventive intervention><programs><randomized control trial><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><risk for obesity><risk of obesity><risk-reducing><therapeutic efficacy><therapy design><therapy efficacy><tool><treatment design><virtual intervention><waitlist><weights><youngster>
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Karla Ivette Galaviz

TRUSTEES OF INDIANA UNIVERSITY, BLOOMINGTON, IN

Exploratory lead · 10/100
Active award
$118,875
FY 2025

Project Title

Improving hypertension care for persons with HIV in Indiana: a participatory agent-based model

Grant Number:

5R03HL174207-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2024

End Date:

8/31/2026

Project Abstract

ABSTRACT Cardiovascular disease (CVD) has become a leading cause of morbidity and mortality in persons with HIV (PWH). Although clinical guidelines recommend detecting and addressing CVD risk among PWH, CVD prevention has not been effectively implemented in routine HIV Care. Addressing this implemen...

Research Terms

<21+ years old><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adopted><Adoption><Adult><Adult Human><Affect><Area><Awareness><CVD prevention><Calibration><Cardiovascular Diseases><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Caring><Cause of Death><Clinic><Clinical><Communities><Computer Models><Computerized Models><County><Data><Detection><Diagnosis><Disease Outcome><Education><Educational aspects><Educational workshop><Engineering><Epidemic><Event><Feedback><Goals><Grant><Guideline Adherence><Guidelines><HIV><HIV Infections><HIV Seronegativities><HIV Seronegativity><HIV negative><HTLV-III Infections><HTLV-III Seronegativities><HTLV-III Seronegativity><HTLV-III-LAV Infections><Health><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Hybrids><Hypertension><Indiana><Investigators><K-Awards><K-Series Research Career Programs><LAV-HTLV-III><Leadership><Lymphadenopathy-Associated Virus><Mentors><Methods><Mission><Modeling><Modification><Morbidity><Morbidity - disease rate><Motivation><NHLBI><National Heart, Lung, and Blood Institute><Output><Patients><Persons><Population><Prevalence><Preventative care><Preventive><Preventive care><Public Health><Recommendation><Research><Research Career Program><Research Personnel><Research Priority><Research Resources><Researchers><Resources><Retrospective cohort><Risk Factors><Risk Management><Science><System><Testing><Validation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Virus-HIV><Work><Workshop><adulthood><burden of disease><burden of illness><cardiac disease prevention><cardiovascular disease prevention><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder prevention><cardiovascular disorder risk><cardiovascular risk><cardiovascular risk factor><care outcomes><career><community advisory board><community advisory committee><community advisory panel><community engagement><computational modeling><computational models><computer based models><computerized modeling><data diversity><design><designing><disease burden><diverse data><engagement with communities><experience><health care outcomes><high blood pressure><hyperpiesia><hyperpiesis><hypertension treatment><hypertensive disease><hypertensive disorder><implementation research><implementation strategy><improved><mortality><programs><prototype><response><service providers><strategies for implementation><systemic inflammation><systemic inflammatory response><tool><treatment guidelines><validations>
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Matthew Scott Zinter

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 10/100
Active award
$118,720
FY 2025

Project Title

Investigation of pulmonary fibrosis biology in pediatric hematopoietic cell transplant patients

Grant Number:

5R03HL171423-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/15/2024

End Date:

7/31/2026

Project Abstract

Project Summary/Abstract Allogeneic hematopoietic cell transplantation (HCT) was developed in the 1950’s as a treatment option for life- threatening malignant and non-malignant diseases. The process involves high dose chemoradiotherapy followed by intravenous infusion of a donor allograft with the i...

Research Terms

<0-11 years old><Ablation><Acute><Acute Radiation Syndrome><Address><Affect><Age><Allogenic><Allografting><Alveolar><Alveolar Macrophages><Biological><Biology><Biopsy><Blood><Blood Diseases><Blood Reticuloendothelial System><Blood Sample><Blood monocyte><Blood specimen><Bone-Derived Transforming Growth Factor><Bronchioalveolar Lavage><Bronchoalveolar Lavage><Bronchoalveolar Lavage Fluid><Bronchopulmonary Lavage><Cancer Treatment><Cancers><Cell Communication and Signaling><Cell Signaling><Cessation of life><Chest imaging><Child><Child Youth><Childhood><Children (0-21)><Chronic><Cicatrix><Clinical><Clinical Evaluation><Clinical Testing><Collagen><Data><Death><Defect><Deposit><Deposition><Development><Diagnosis><Diffusion><Disease><Disorder><Dose><Early identification><Epithelial Cells><Epithelium><Expression Signature><Fibroblasts><Fibrosis><Future><Gene Expression><Gene Expression Profile><Genes><Goals><Grant><HSC transplantation><Hematologic Diseases><Hematological Disease><Hematological Disorder><Hematopoietic><Hematopoietic Stem Cell Transplant><Hematopoietic Stem Cell Transplantation><Herpesviridae><Herpesviruses><High Dose Chemotherapy><Histologic><Histologically><Histology><Hospital Mortality><Hyperplasia><Hyperplastic><Hypoxia><Hypoxic><IV Infusion><Impairment><In-house Mortalities><Infection><Inflammation><Inhospital Mortality><Injury><Intention><Intervention Trial><Interventional trial><Intracellular Communication and Signaling><Intravenous infusion procedures><Investigation><Life><Link><Lung><Lung Function Tests><Lung Inflammation><Lung Lavage><Lung Respiratory System><Lung Tissue Fibrosis><Lung damage><MMPs><Malignant><Malignant - descriptor><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Marrow><Marrow monocyte><Mass Photometry/Spectrum Analysis><Mass Spectrometry><Mass Spectroscopy><Mass Spectrum><Mass Spectrum Analyses><Mass Spectrum Analysis><Matrix Metalloproteinases><Measures><Mesenchymal><Milk Growth Factor><Molecular><Molecular Fingerprinting><Molecular Profiling><Morbidity><Morbidity - disease rate><NHLBI><National Heart, Lung, and Blood Institute><Non-Malignant><Outcome><Oxygen Deficiency><Pathway interactions><Patient Selection><Patients><Pediatric cohort><Phenotype><Physiology><Platelet Transforming Growth Factor><Pneumonitis><Population><Premature Mortality><Process><Production><Proteins><Proteomics><Pulmonary Fibrosis><Pulmonary Inflammation><Pulmonary Macrophages><Pulmonary function tests><QOL><Quality of life><Radiation Toxicity><Radiography><Radiotoxicity><Risk><Roentgenography><Safety><Sampling><Scars><Screening procedure><Signal Transduction><Signal Transduction Systems><Signaling><Survivors><T-Cells><T-Lymphocyte><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><Testing><Therapeutic Intervention><Thoracic imaging><Time><Toxicity due to chemotherapy><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Transplant Recipients><Transplantation Conditioning><United States><Upregulation><Work><acute infection><ages><alloimmunity><anti-cancer therapy><antifibrotic agent><antifibrotic medication><antifibrotic therapy><antifibrotic treatment><biologic><biological sex><biological signal transduction><blood disorder><blood stem cell transplantation><bronchiolar alveolar lavage><bronchopulmonary lavage therapy><cancer therapy><cancer-directed therapy><chemo-/radio-therapy><chemo-radiotherapy><chemoradiation><chemoradiation therapy><chemoradiation treatment><chemoradiotherapy><chemotherapy><chemotherapy toxicity><clinical test><cohort><death risk><decline in function><decline in functional status><developmental><diffused><diffuses><diffusing><diffusions><epithelial injury><fibrogenesis><fibrosis in the lung><functional decline><functional status decline><gene expression pattern><gene expression signature><hazard><hematopoietic cell transplantation><hematopoietic cellular transplantation><hematopoietic progenitor cell transplantation><hemopoietic><herpes virus><high risk><high risk group><high risk individual><high risk people><high risk population><hypoimmunity><immune deficiency><immune reconstitution><immunodeficiency><improved><infection recurrence><injuries><insight><interstitial><intervention design><intervention therapy><intravenous infusion><isoimmunity><kids><lung fibrosis><lung function><lung injury><malignancy><molecular profile><molecular signature><monocyte><mortality risk><neoplasm/cancer><nonmalignant><novel><pathway><pediatric><premature><prematurity><proteomic signature><pulmonary><pulmonary damage><pulmonary function><pulmonary injury><pulmonary tissue damage><pulmonary tissue injury><radiation poisoning><radio-chemo-therapy><radio-chemotherapy><radiochemotherapy><radiological imaging><recurrent infection><recurring infection><research clinical testing><respiratory><screening tools><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapy design><thymus derived lymphocyte><transcriptional profile><transcriptional signature><transcriptomics><transplant patient><transplant survivor><treatment design><treatment strategy><youngster>
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Matthew J Rossman

UNIVERSITY OF COLORADO, Boulder, CO

Exploratory lead · 10/100
Active award
$117,375
FY 2025

Project Title

Circulating factors as a mechanism of improvements in vascular endothelial function with inorganic nitrate in patients with chronic kidney disease

Grant Number:

5R03DK140289-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

5/31/2026

Project Abstract

PROJECT SUMMARY Cardiovascular disease (CVD) is the leading cause of death in patients with chronic kidney disease (CKD). Vascular endothelial dysfunction is a key antecedent to CVD in patients with CKD. A primary mechanism of endothelial dysfunction in CKD is a decline in the vasoprotective molecul...

Research Terms

<Acetylcholine><Actions of Nitric Oxide in the Heart><Active Oxygen><Age Years><Antioxidants><Aorta><Attenuated><Bioavailability><Biological><Biological Availability><Biomedical Research><Blood><Blood Plasma><Blood Reticuloendothelial System><Blood Vessels><Buccal Cavity><Buccal Cavity Head and Neck><Cardiovascular Diseases><Cause of Death><Cavitas Oris><Cell Culture Techniques><Cell Function><Cell Physiology><Cell Process><Cellular Function><Cellular Physiology><Cellular Process><Chronic><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Circulation><Clinical Trials><Consumption><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Endogenous Nitrate Vasodilator><Endothelial Cells><Endothelium><Endothelium-Derived Nitric Oxide><Exposure to><Glomerular Filtration Rate><Health><Human><Individual><Ingestion><Intervention><Juice><K01 Award><K01 Mechanism><K01 Program><Mediating><Mentored Research Scientist Development Award><Mentored Training Award><Mitochondria><Modern Man><Molecular><Mononitrogen Monoxide><Mouth><NO3-><Nitrates><Nitric Oxide><Nitric Oxide Pathway><Nitrite Reductase><Nitrites><Nitrogen Monoxide><Nitrogen Protoxide><Oral cavity><Oxidative Stress><Oxygen Radicals><Pathway interactions><Patients><Phase 2 Clinical Trials><Phase II Clinical Trials><Physiologic Availability><Placebos><Plasma><Plasma Serum><Pro-Oxidants><Production><Randomized><Reactive Oxygen Species><Research><Research Priority><Research Scientist Development Award><Reticuloendothelial System, Serum, Plasma><Role><Sampling><Sham Treatment><Signal Pathway><Sodium Nitrite><Source><Subcellular Process><Supplementation><Testing><Transducers><Translating><Vascular Diseases><Vascular Disorder><Vascular Endothelium><Woman><active method><active technique><active treatment><attenuate><attenuates><biologic><blood vessel disorder><brachial artery><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cell culture><cell cultures><chronic kidney disease><commensal bacteria><commensal bacterial species><determine efficacy><dietary nitrate><effective therapy><effective treatment><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><endothelial cell derived relaxing factor><endothelial dysfunction><evaluate efficacy><examine efficacy><fitness><high risk><improved><ingest><innovate><innovation><innovative><insight><men><metabolism measurement><metabolome><metabolomics><metabonome><metabonomics><mitochondrial><new approaches><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><nitrate><novel><novel approaches><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel strategies><novel strategy><novel therapeutics><novel therapy><older adult><older adulthood><pathway><phase II protocol><primary outcome><randomisation><randomization><randomized, clinical trials><randomly assigned><sham therapy><social role><sodium salt Nitrous acid><translation strategy><translational approach><translational strategy><vascular><vascular dysfunction><vascular endothelial dysfunction><vasculopathy>
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Mia Smith

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 10/100
Active award
$117,000
FY 2025

Project Title

Role of Ptpn2 in B cells during development of autoimmunity

Grant Number:

5R03OD036470-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

5/31/2026

Project Abstract

Project Summary This R03 proposal is to follow-up on recent findings from my SERCA K01 award, which focuses on elucidating the role of the type 1 diabetes (T1D) PTPN2 risk allele in loss of B cell anergy. Previously B cells bearing antigen receptors with high affinity for insulin were found only in...

Research Terms

<1st degree relative><7S Gamma Globulin><Acceleration><Active Follow-up><Affect><Affinity><Age><Alleles><Allelomorphs><Antibodies><Antigen Presentation><Antigen Receptors><Antigen-Presenting Cells><Autoantibodies><Autoantigens><Autoimmune><Autoimmune Diabetes><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Autologous Antigens><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Beta Cell><Blood><Blood Reticuloendothelial System><Brittle Diabetes Mellitus><C57BL/6 Mouse><Cell Body><Cell Communication and Signaling><Cell Compartmentation><Cell Compartmentations><Cell Signaling><Cells><Clonal Abortions><Clonal Deletion><Complex><Cytosolic Protein Tyrosine Phosphastase><DNA><Deoxyribonucleic Acid><Development><Diabetes Mellitus><Diabetic mouse><Disease><Disorder><Environmental Factor><Environmental Risk Factor><Exhibits><First Degree Relative><Frequencies><Future><GWA study><GWAS><Gene variant><Genes><Genetic><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic propensity><Goals><HL-A Antigens><HLA Antigens><Human><Human Leukocyte Antigens><Humulin R><Hyperglycemia><IDDM><IgG><Immune Tolerance><Immunoglobulin G><Immunologic Tolerance><Impairment><Inbred NOD Mice><Incidence><Individual><Inguinal Lymph Node><Inguinal lymph node group><Inherited Predisposition><Inherited Susceptibility><Insulin><Insulin Antibodies><Insulin Cell><Insulin Secreting Cell><Insulin-Dependent Diabetes Mellitus><Intracellular Communication and Signaling><Juvenile-Onset Diabetes Mellitus><K01 Award><K01 Mechanism><K01 Program><Ketosis-Prone Diabetes Mellitus><Knock-out><Knockout><Knowledge><Leukocyte Antigens><Lymph Node Reticuloendothelial System><Lymph node proper><Lymphatic cell><Lymphatic nodes><Lymphocyte><Lymphocytic><Maintenance><Mentored Research Scientist Development Award><Mentored Training Award><Mice><Mice Mammals><Modern Man><Murine><Mus><NOD Mouse><Non obese><Non-Obese Diabetic Mice><Nonobese><Nonobese Diabetic Mouse><Novolin R><PTP Family Gene><PTPase><Pancreas><Pancreatic><Pancreatic beta Cell><Pancreatic β-Cell><Pathogenesis><Pathogenicity><Patients><Penetrance><Phenotype><Phosphotyrosine Phosphatase><Phosphotyrosyl Protein Phosphatase><Prediabetes><Prediabetes syndrome><Prediabetic State><Production><Protein Tyrosine Phosphatase><Protein Tyrosine Phosphatase Gene><Receptor Protein><Receptor Type PTP Gene><Regular Insulin><Research Scientist Development Award><Resistance><Risk><Risk-associated variant><Role><Self-Antigens><Signal Transduction><Signal Transduction Systems><Signaling><Single Base Polymorphism><Single Nucleotide Polymorphism><Spleen><Spleen Reticuloendothelial System><Structure of beta Cell of islet><Sudden-Onset Diabetes Mellitus><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T1 DM><T1 diabetes><T1D><T1DM><Testing><Therapeutic><Translating><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Tyrosine Phosphatase><Tyrosyl Phosphoprotein Phosphatase><accessory cell><active followup><ages><allelic variant><anergy><autoimmune antibody><autoimmune condition><autoimmune disorder><autoimmune reactivity><autoimmunity disease><autoreactive B cell><autoreactive antibody><autoreactivity><biological signal transduction><co-morbid><co-morbidity><comorbidity><compare to control><comparison control><developmental><diabetes><diabetes mouse model><diabetic><environmental risk><follow up><follow-up><followed up><followup><genetic etiology><genetic mechanism of disease><genetic variant><genetic vulnerability><genetically predisposed><genome wide association><genome wide association scan><genome wide association study><genomewide association scan><genomewide association study><genomic variant><high risk><hyperglycemic><immune system tolerance><immune unresponsiveness><immunological paralysis><insulin dependent diabetes><insulin dependent diabetes mellitus onset><insulin dependent type 1><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><lymph cell><lymph gland><lymph nodes><lymphnodes><mouse model><murine model><new drug target><new drug treatments><new druggable target><new drugs><new pharmacological therapeutic><new pharmacotherapy target><new therapeutic target><new therapeutics><new therapy><new therapy target><next generation therapeutics><non-obese diabetic (NOD) mice><nonobese diabetic (NOD) mice><novel drug target><novel drug treatments><novel druggable target><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel pharmacotherapy target><novel therapeutic target><novel therapeutics><novel therapy><novel therapy target><pancreas beta cell><pancreas β cell><pancreatic b-cell><pre-diabetes><pre-diabetic><prediabetic><prevent><preventing><protein tyrosine phosphate phosphohydrolase><receptor><resistant><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><self reactive B cell><self reactive antibody><single nucleotide variant><social role><thymus derived lymphocyte><type 1 diabetes onset><type I diabetes><type one diabetes><whole genome association analysis><whole genome association study><β-cell><β-cells><βCell>
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Rodolfo Galindo

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, CORAL GABLES, FL

Exploratory lead · 10/100
Active award
$115,125
FY 2025

Project Title

Pharmaco-epidemiology of diabetes in patients with end-stage kidney disease

Grant Number:

5R03DK138255-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/15/2024

End Date:

11/30/2026

Project Abstract

Project Summary Diabetes is a leading cause of end-stage kidney disease (ESKD), with about 55-600% of patients on dialysis having diabetes. Glucose management in the context of dialysis is challenging. In recent studies, we reported that patients with diabetes and ESKD have increased risk of severe ...

Research Terms

<21+ years old><Acute><Address><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><African American group><African American individual><African American people><African American population><African Americans><Age><Agonist><Amputation><Anti-diabetic Agents><Anti-diabetic Drugs><Big Data><BigData><Blood capillaries><Bolus><Bolus Infusion><Calibration><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Caring><Cessation of life><Clinical><Clinical Research><Clinical Study><Clinical Trials><Complement><Complement Proteins><Complex><Continuous Glucose Monitor><Coupled><D-Glucose><Data><Data Analyses><Data Analysis><Data Bases><Data Systems><Databases><Death><Devices><Dextrose><Diabetes Mellitus><Dialysis><Dialysis procedure><Disparities><Disparity><Drugs><ED visit><ER visit><ESKD><ESRD><Emergency care visit><Emergency department visit><Emergency hospital visit><Emergency room visit><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Epidemiology><Ethnic Origin><Ethnicity><Event><Exclusion><Formulation><GLP-1 receptor><GLP-I receptor><Glucose><Grant><Half-Life><Health><Heart Vascular><Hispanic Populations><Hispanic group><Hispanic individual><Hispanic people><Hispanics><Hospital Admission><Hospitalization><Human><Humulin R><Hyperglycemia><Hypertension><Hypoglycemia><IT Systems><Incidence><Individuals from minority><Individuals of minority><Information Systems><Information Technology Systems><Infusion><Infusion procedures><Insulin><Insulin Infusion Systems><Interdisciplinary Research><Interdisciplinary Study><Intramural Research><Ketosis-Resistant Diabetes Mellitus><Kidney><Kidney Urinary System><Knowledge><Maturity-Onset Diabetes Mellitus><Medication><Microvascular Dysfunction><Minority Groups><Minority People><Minority Population><Minority individual><Modern Man><Monitor><Multidisciplinary Collaboration><Multidisciplinary Research><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Novolin R><Observation research><Observation study><Observational Study><Observational research><Outcome><Outcomes Research><Patients><Pattern><Persons><Pharmaceutical Epidemiology><Pharmaceutical Preparations><Pharmacoepidemiology><Population><Position><Positioning Attribute><Prevalence><Prospective Studies><Pump><Race><Races><Randomization trial><Recommendation><Regimen><Regular Insulin><Renal clearance function><Reporting><Research Infrastructure><Retinal Diseases><Retinal Disorder><Risk><Risk Reduction><Safety><Sampling><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Standardization><Subgroup><Sulfonylurea Compounds><System><T2 DM><T2D><T2DM><Technology><Testing><Time><Translational Research><Translational Science><Treatment Protocols><Treatment Regimen><Treatment Schedule><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Work><adult onset diabetes><adulthood><adverse event risk><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging population><analog><anti-diabetic><capillary><cardiovascular disorder><circulatory system><co-morbid><co-morbidity><comorbidity><complementation><continuous blood glucose monitor><continuous blood sugar monitor><continuous glucose measurement><continuous sugar monitor><data base><data interpretation><design><designing><diabetes><diabetes management><diabetes mellitus management><diabetic management><dialysis therapy><drug epidemiology><drug/agent><elderly patient><epidemiologic><epidemiological><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><experience><glucagon-like peptide-1 receptor><glucose metabolism><glycemic control><high blood pressure><high risk><high risk group><high risk individual><high risk people><high risk population><hospital re-admission><hospital re-admission rates><hospital readmission><hospital readmission rate><hyperglycemic><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><hypoglycemic><hypoglycemic episodes><improved><infusions><inhibitor><insulin infusion device><insulin infusion pump><insulin pump><insulin sensitivity><ketosis resistant diabetes><maturity onset diabetes><microvascular complications><microvascular disease><mortality><multidisciplinary><novel><older patient><patient centered><patient oriented><pharmacoepidemiologic><pharmacoepidemiological><pharmacologic><population aging><prevent><preventing><programs><prospective><racial><racial background><racial minority group><racial minority individual><racial minority people><racial minority population><racial origin><randomized trial><randomized, clinical trials><re-admission><re-admission rates><re-hospitalization><re-hospitalization rate><readmission><readmission rates><reduce risk><reduce risks><reduce that risk><reduce the risk><reduce these risks><reduces risk><reduces the risk><reducing risk><reducing the risk><rehospitalization><rehospitalization rate><renal><renal clearance><retina disease><retina disorder><retinopathy><risk-reducing><sensor><sex><small vessel disease><standard of care><subcutaneous><subdermal><sulfonylurea><translation research><translational impact><translational investigation><trend><type 2 DM><type II DM><type two diabetes>
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Stephanie Manasse

NEMOURS CHILDREN'S HOSPITAL, DELAWARE, WILMINGTON, DE

Exploratory lead · 10/100
Active award
$114,000
FY 2025

Project Title

Improving sleep as a method for enhancing decision-making and reducing problematic eating behaviors in adolescents with obesity

Grant Number:

7R03DK138216-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2024

End Date:

1/31/2027

Project Abstract

ABSTRACT Adolescent overweight/obesity affects (AOB) 14 million adolescents in the United States, increasing their risk of type 2 diabetes, cardiovascular disease, and cancer. Unfortunately, adolescents show suboptimal response to behavioral pediatric obesity interventions, with a modal weight loss ...

Research Terms

<12-20 years old><21+ years old><Acceleration><Accelerometer><Address><Adolescence><Adolescent><Adolescent Youth><Adolescent obesity><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Affect><After Care><After-Treatment><Aftercare><Age><Award><BMI><BMI percentile><BMI z-score><Behavior><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Binge Eating><Body Weight decreased><Body mass index><Caloric Intake><Cancers><Cardiovascular Diseases><Case Series><Childhood><Cognitive><Conditioning Therapy><Data><Decision Making><Diabetes Mellitus><Diagnostic><Dietary intake><Eating><Eating Behavior><Emotional><Emotions><Energy Intake><Feedback><Food><Food Intake><Future><Goals><Hyperphagia><Intervention><K23 Award><K23 Mechanism><K23 Program><Ketosis-Resistant Diabetes Mellitus><Life Style Modification><Link><Literature><Malignant Neoplasms><Malignant Tumor><Manuals><Maturity-Onset Diabetes Mellitus><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Meta-Analysis><Methods><Modality><Modeling><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Obesity><Outcome><Over weight><Overeating><Overweight><Parents><Participant><Pathway interactions><Phase><Prevalence><Public Health><Quetelet index><Research><Rewards><Risk><Schedule><Schools><Sleep><Sleep disturbances><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Stimulus><T2 DM><T2D><T2DM><Testing><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><United States><Weight><Weight Gain><Weight Increase><Weight Loss><Weight Reduction><Work><Youth><Youth 10-21><aberrant sleep><accelerometry><activity monitor><activity tracker><adiposity><adolescence (12-20)><adult onset diabetes><adulthood><ages><behavior intervention><behavioral intervention><behavioral sleep health intervention><behavioral sleep health program><behavioral sleep intervention><behavioral sleep strategies><behavioral sleep therapy><behavioral sleep treatment><body weight gain><body weight increase><body weight loss><caloric dietary content><cardiovascular disorder><career><child adiposity><child obesity><childhood adiposity><childhood obesity><circadian><compulsive eating><compulsive feeding><compulsive overeating><corpulence><design><designing><diabetes><diaries><disrupted sleep><disturbed sleep><efficacy testing><emotion regulation><emotional regulation><evidence base><excessive weight gain><extreme weight gain><impaired sleep><improved><improved outcome><improvement on sleep><irregular sleep><juvenile><juvenile human><ketosis resistant diabetes><lifestyle modification><malignancy><maturity onset diabetes><negative affect><negative affectivity><neoplasm/cancer><neural><obese adolescents><obese children><obesity among adolescents><obesity during adolescence><obesity during childhood><obesity in adolescence><obesity in adolescents><obesity in children><obesity intervention><obesity risk><obesity therapy><obesity treatment><outcome prediction><parent><pathway><pediatric><pediatric obesity><polyphagia><post treatment><programs><prospective><psychologic><psychological><recruit><response><risk for obesity><risk of obesity><screen time><serious weight gain><severe weight gain><sleep disruption><sleep dysregulation><sleep improvement><sleep/wake disruption><sleep/wake disturbance><social><television watching><tv watching><type 2 DM><type II DM><type two diabetes><weight loss intervention><weight loss therapy><weight loss treatment><weights><wt gain><wt-loss><youth adiposity><youth age>
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Amy C Engevik

MEDICAL UNIVERSITY OF SOUTH CAROLINA, CHARLESTON, SC

Exploratory lead · 10/100
Active award
$113,250
FY 2025

Project Title

Understanding the role of Myosin 5b in liver metabolism

Grant Number:

5R03DK139282-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2024

End Date:

4/30/2027

Project Abstract

Project Summary Myosin 5b is responsible for transporting key apical proteins to the surface of epithelial cells. Myosin 5b is most widely studied because of its association with Microvillus Inclusion Disease, a congenital diarrhea disorder in which inactivating mutations in Myosin 5b is a primary c...

Research Terms

<Actin-Activated ATPase><Address><Alimentary Canal><Animal Model><Animal Models and Related Studies><Apical><Assay><Autoregulation><Bile Acids><Bile Duct Obstruction><Biliary Stasis><Bioassay><Bioenergetics><Biological Assay><Blood Circulation><Blood Glucose><Blood Sugar><Bloodstream><Body Tissues><Carbohydrates><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cells><Cholestasis><Confocal Microscopy><D-Glucose><DNA mutation><Data><Defect><Dextrose><Diarrhea><Digestive Tract><Disease><Disorder><Electron Microscopy><Enzyme Gene><Enzymes><Epithelial Cells><Exhibits><F-Actin><Family><Fatty Acids><Filamentous Actin><Frequencies><Funding><Future><GI Tract><GLUT-2 protein><GLUT2><GLUT2 gene><GLUT2 protein><Gastrointestinal Tract><Gastrointestinal tract structure><Generations><Genes><Genetic Change><Genetic defect><Genetic mutation><Genus Hippocampus><Germ Lines><Glucose><Glucose Binding Protein><Glucose Transport Protein><Glucose Transporter><Glucose transporter type 2 protein><Glycogen><Golgi><Golgi Apparatus><Golgi Complex><Hepatic Cells><Hepatic Disorder><Hepatic Glycogen><Hepatic Parenchymal Cell><Hepatic mitochondria><Hepatocyte><Homeostasis><Human><Immobilization><In Vitro><Individual><Intermediary Metabolism><Intestinal><Intestines><Intracellular Transport><K-Awards><K-Series Research Career Programs><K01 Award><K01 Mechanism><K01 Program><KO mice><Knock-out Mice><Knockout Mice><Knowledge><Link><Lipids><Liver><Liver Cells><Liver Glycogen><Liver Mitochondria><Liver diseases><Mentored Research Scientist Development Award><Mentored Training Award><Mentors><Metabolic><Metabolic Pathway><Metabolic Processes><Metabolism><Mice><Mice Mammals><Microvillus inclusion disease><Mitochondria><Modern Man><Molecular><Molecular Motors><Morphology><Murine><Mus><Mutation><Myosin ATPase><Myosin Adenosine Triphosphatase><Myosin Adenosinetriphosphatase><Myosins><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Null Mouse><Nutrient><Organ><Organelles><Organoids><Oxygen Consumption><Pathway interactions><Physiological Homeostasis><Play><Position><Positioning Attribute><Postdoc><Postdoctoral Fellow><Prebeta-Lipoproteins><Process><Production><Proteins><Regulation><Reporting><Research><Research Associate><Research Career Program><Research Proposals><Research Scientist Development Award><Research Technics><Research Techniques><Resolution><Respiration><Role><Seahorse><Secure><Site><Surface><Testing><Tissues><Triacylglycerol><Triglycerides><VLDL><VLDL Lipoproteins><Very low density lipoprotein><Work><adipogenesis><alimentary tract><apical membrane><base><bases><bile obstruction><bile occlusion><blood glucose regulation><bowel><cholestatic diseases><cholestatic disorder><cholestatic liver disease><cholestatic liver disorder><cholestatic syndromes><compare to control><comparison control><confocal imaging><digestive canal><experiment><experimental research><experimental study><experiments><extracellular><fat metabolism><fatty acid oxidation><genome mutation><glucose control><glucose homeostasis><glucose regulation><glucose uptake><glycogen metabolism><hepatic body system><hepatic disease><hepatic metabolism><hepatic organ system><hepatopathy><in vivo><interest><intestinal epithelium><knock-out animal><knockout animal><lipid biosynthesis><lipid metabolism><lipogenesis><liver disorder><liver function><liver imaging><liver metabolism><liver scanning><mitochondrial><model of animal><mouse model><murine model><nutrient absorption><orthopedic freezing><oxidation><pathway><peroxisome><post-doc><post-doctoral><post-doctoral trainee><prevent><preventing><research associates><resolutions><respiratory mechanism><social role><solute carrier family 2, facilitated glucose transporter, member 2 protein><trafficking><treadmill><uptake>
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Jacqueline F Hayes

MIRIAM HOSPITAL, PROVIDENCE, RI

Exploratory lead · 10/100
Active award
$111,750
FY 2025

Project Title

Human-Centered Design of a Behavioral Intervention to Reverse Small Weight Regains during Weight Loss Maintenance

Grant Number:

1R03DK142991-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2025

End Date:

5/31/2027

Project Abstract

PROJECT SUMMARY/ABSTRACT Weight loss maintenance (WLM) is the most pressing issue in current obesity treatments. WLM programs mitigate, but do not prevent, weight regain and individuals who lose weight have trouble re-instating weight loss efforts despite having used them effectively during weight l...

Research Terms

<Accountability><Address><Award><Back><Behavior><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Mechanisms><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Body Weight decreased><Calories><Chronic Disease><Chronic Illness><Cognition><Conditioning Therapy><Control Groups><Data><Data Analyses><Data Analysis><Data Set><Diamond><Dorsum><Educational workshop><Effectiveness><Future><Grant><Individual><Intervention><Interview><Lived experience><Lived experiences><Maintenance><Measurement><Mechanisms of Behavior and Behavior Change><Methods><Modeling><Modification><Monitor><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Participant><Phase><Physical activity><Play Intervention><Play Therapy><Process><Protocol><Protocols documentation><Questionnaires><Randomized><Randomized, Controlled Trials><Recovery><Recovery Support><Research><Research Activity><Role Playing><Role playing therapy><Stress><Testing><Weight><Weight Gain><Weight Increase><Weight Loss><Weight Reduction><Weight maintenance regimen><Workshop><behavior intervention><behavior mechanism><behavioral intervention><body weight gain><body weight increase><body weight loss><chronic disorder><coaching calls><compare intervention><compare to control><comparison control><comparison intervention><data interpretation><design><designing><develop therapy><efficacy testing><experience><human centered design><improved><innovate><innovation><innovative><intervention development><intervention refinement><obesity intervention><obesity management><obesity therapy><obesity treatment><phone coach><prevent><preventing><programs><prototype><psychologic><psychological><randomisation><randomization><randomized control trial><randomly assigned><satisfaction><secondary analysis><skills><smart scale><telephone based coaching><telephone coaching><telephone counseling><therapy development><treatment development><usability><weight control><weight loss intervention><weight loss therapy><weight loss treatment><weight management><weights><work group><working group><wt gain><wt-loss>
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KayLoni L. Olson

MIRIAM HOSPITAL, PROVIDENCE, RI

Exploratory lead · 10/100
Active award
$111,750
FY 2025

Project Title

Optimizing a Weight Neutral Intervention to Improve Health Among Adults of Higher Body Weight: A MOST Preparation Phase Study

Grant Number:

1R03DK140291-01A1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/15/2025

End Date:

5/31/2027

Project Abstract

Project Summary Obesity remains a major public health concern and is a leading contributor to cardiometabolic disease. Frontline treatments aim to directly facilitate weight loss, but outcomes are variable and difficult to sustain. Weight neutral approaches are gaining scientific, clinical, and publ...

Research Terms

<21+ years old><Adherence><Adult><Adult Human><Advocate><Aerobic Activity><Aerobic Exercise><Aerobic Training><Aerobic fitness><American><Attention><Awareness><BMI><BMI percentile><BMI z-score><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Benchmarking><Best Practice Analysis><Body Weight><Body Weight decreased><Body mass index><Cardiometabolic Disease><Cardiometabolic Disorder><Caucasian Females><Caucasian Women><Clinical><Combined Modality Therapy><Complement><Complement Proteins><Conditioning Therapy><Cues><Data><Development><Diet><Dietary intake><Dietary quality><Eating><Education><Educational aspects><Enrollment><Ensure><Evaluation><Evidence based intervention><Food><Food Intake><Funding><Goals><Guidelines><Health><Health Benefit><Healthy diet><Hunger><Individual><Intervention><Long-term Follow-up><Mediterranean Diet><Methodology><Morbidity><Morbidity - disease rate><Multimodal Therapy><Multimodal Treatment><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Obesity><Outcome><Pathway interactions><Personal Satisfaction><Persons><Phase><Physical activity><Position><Positioning Attribute><Preparation><Protocol><Protocols documentation><Public Health><QOL improvement><Quetelet index><Racial Group><Randomized><Recommendation><Research><Research Resources><Resources><Sampling><Satiation><Science><Sedentary behavior><Sedentary life-style><Standardization><Target Populations><Testing><Therapeutic><Time><Training><Weight><Weight Loss><Weight Reduction><White Females><White Women><Woman><Work><adiposity><adulthood><balanced diet><behavior intervention><behavioral intervention><benchmark><body weight loss><cardiometabolic><cardiometabolic risk><cardiometabolism><career><combination therapy><combined modality treatment><combined treatment><complementation><corpulence><delivered remotely><design><designing><developmental><diet quality><dietary><diets><effective intervention><enroll><ethnic diversity><ethnically diverse><evidence base><experiment><experimental research><experimental study><experiments><good diet><high risk group><high risk individual><high risk people><high risk population><improved><improvements in QOL><improvements in quality of life><interest><life style intervention><lifestyle intervention><long-term followup><men><mindfulness><mortality><multi-modal therapy><multi-modal treatment><multiphase optimization strategy><muscle strengthening><novel><obesity intervention><obesity therapy><obesity treatment><pathway><pilot test><preparations><programs><quality of life improvement><racial diversity><racial population><racial subgroup><racially diverse><randomisation><randomization><randomly assigned><recruit><remote delivery><response><restraint><satiety><satisfaction><screening><screenings><sedentary lifestyle><social stigma><stigma><strength training><treatment effect><uptake><weights><well-being><wellbeing><wt-loss>
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Ida Tchuisseu Fonkoue

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 10/100
Active award
$106,636
FY 2025

Project Title

Longitudinal changes in vascular and autonomic function in premenopausal women with PTSD

Grant Number:

5R03HL174817-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/17/2024

End Date:

7/31/2026

Project Abstract

Project Summary The ultimate objective of this R03 proposal is to enable Dr. Ida Fonkoue to launch her independent research career by 1) expanding her current K01 research objectives; 2) providing additional support in her transition to a future NIH R01 grant; and 3) generating sufficient preliminar...

Research Terms

<21+ years old><Acceleration><Active Follow-up><Adult><Adult Human><Age><Aquadiol><Autonomic Dysfunction><Award><BMI><BMI percentile><BMI z-score><Bioavailability><Biological><Biological Availability><Blood Plasma><Blood Vessels><Body mass index><Cardiac Diseases><Cardiac Disorders><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular Physiology><Cardiovascular system><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cause of Death><Centers for Disease Control><Centers for Disease Control and Prevention><Centers for Disease Control and Prevention (U.S.)><Characteristics><Chronic stress><Clinical><Clinical Research><Clinical Sciences><Clinical Study><Data><Development><Diagnosis><Diglycolaldehyde><Dimenformon><Diogyn><Diogynets><Disease><Disorder><Endocrine Gland Secretion><Endogenous Nitrate Vasodilator><Endothelium><Endothelium-Derived Nitric Oxide><Environment><Estrace><Estradiol><Estradiol-17 beta><Estradiol-17beta><Estraldine><Estrogenic Agents><Estrogenic Compounds><Female><Female Health><Female of child bearing age><Female of childbearing age><Follow-Up Studies><Followup Studies><Foundations><Funding><Future><Generalized Anxiety Disorder><Goals><Grant><Health><Heart Diseases><Heart Vascular><Hormonal><Hormones><Hour><Hypertension><IdA><Impairment><Inosine Dialdehyde><Inox><Intervention Strategies><K-Awards><K-Series Research Career Programs><Lead><Long-Term Effects><Longitudinal Studies><Master of Science><Master's Degree><Measures><Mediating><Menopause><Mentorship><Minnesota><Mononitrogen Monoxide><NIH><National Institutes of Health><Nerve><Neuroendocrine><Neuroendocrine System><Neurosecretory Systems><Nitric Oxide><Nitrogen Monoxide><Nitrogen Protoxide><Outcome><Ovocyclin><Ovocylin><PTSD><Panic Disorder><Pathology><Pathway interactions><Pb element><Peripheral><Physiologic Availability><Plasma><Plasma Serum><Play><Population><Post-Menopause><Post-Traumatic Neuroses><Post-Traumatic Stress Disorders><Post-menopausal Period><Postmenopausal Period><Postmenopause><Posttraumatic Neuroses><Pre-Menopause><Pre-menopausal Period><Premenopausal><Premenopausal Period><Premenopause><Prevalence><Preventative strategy><Prevention strategy><Preventive strategy><Production><Progynon><Psyche structure><Quetelet index><R-Series Research Projects><R01 Mechanism><R01 Program><Research><Research Career Program><Research Grants><Research Project Grants><Research Projects><Research Resources><Resources><Rest><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Role><Severities><Sleep><Sleep disturbances><Stress><Survey Instrument><Surveys><Sympathetic Nervous System><Testing><Therapeutic Estradiol><Therapeutic Hormone><Time><Translational Research><Translational Science><Trauma><United States><United States Centers for Disease Control><United States Centers for Disease Control and Prevention><United States National Institutes of Health><Universities><Vascular Diseases><Vascular Disorder><Vascular Endothelium><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Vulnerable Populations><Woman><Women's Health><Women's mortality><Work><aberrant sleep><actigraph><actigraphy><active followup><adulthood><after menopause><ages><arterial stiffening><arterial stiffness><arterial tonometry><artery stiffening><artery stiffness><biologic><blood vessel disorder><brachial artery><cardioprotectant><cardioprotection><cardioprotective><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cardiovascular function><cardiovascular health><career><career development><circulatory system><death among females><death among women><death in females><death in women><death rate among women><death rate in women><developmental><disrupted sleep><disturbed sleep><early onset><endothelial cell derived relaxing factor><estrogenic><exposure to trauma><female death><female mortality><follow up><follow-up><followed up><following menopause><followup><heart disorder><heavy metal Pb><heavy metal lead><high blood pressure><high risk group><high risk individual><high risk people><high risk population><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><impaired sleep><improved><improvement on sleep><in vivo><irregular sleep><long-term study><longitudinal outcome studies><men><mental><mortality among females><mortality among women><mortality in females><mortality in women><multidisciplinary><neural><neurobiological mechanism><panic anxiety syndrome><past menopause><pathway><post-menopausal><post-trauma stress disorder><postmenopausal><postmenopausal status><posttrauma stress disorder><pre-menopausal><premenopausal status><prevent><preventing><programs><protective effect><sleep disruption><sleep dysregulation><sleep improvement><sleep/wake disruption><sleep/wake disturbance><social role><stress disorder><tonometry><translation research><translational investigation><trauma exposure><traumatic neurosis><vascular><vascular dysfunction><vasculopathy><vulnerable group><vulnerable individual><vulnerable people><women of child bearing age><women of childbearing age><women's death><women's death rate><young woman><♀>
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Molly Leah Tanenbaum

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 10/100
Active award
$104,220
FY 2025

Project Title

After ONBOARDing: Examining drivers of CGM discontinuation following a CGM uptake trial

Grant Number:

5R03DK135840-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

9/30/2026

Project Abstract

Project Summary Type 1 diabetes (T1D) is a chronic disease with a demanding self-management burden. Few (<25%) adults with T1D meet ADA-recommended targets for glycemic control, thereby increasing long-term complication risk. Diabetes technology (insulin pumps; continuous glucose monitoring, or CGM)...

Research Terms

<21+ years old><Abbreviations><Achievement><Achievement Attainment><Active Follow-up><Address><Adopted><Adoption><Adult><Adult Human><Algorithms><American><Attention><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Brittle Diabetes Mellitus><Chronic Disease><Chronic Illness><Clinical><Complication><Conditioning Therapy><Continuous Glucose Monitor><D-Glucose><Data><Data Analyses><Data Analysis><Data Collection><Development><Devices><Dextrose><Diabetes Mellitus><Distress><Dose><Glucose><Goals><Health><Health Benefit><Humulin R><Hypoglycemia><IDDM><Individual><Insulin><Insulin Infusion Systems><Insulin-Dependent Diabetes Mellitus><Insurance><Intervention><Investigation><Juvenile-Onset Diabetes Mellitus><Ketosis-Prone Diabetes Mellitus><Life><Link><Longitudinal Surveys><Measures><Methods><Novolin R><Outcome><Parents><Participant><Patient Self-Report><Preparedness><Psychosocial Factor><QOL><Quality of life><Randomized, Controlled Trials><Readiness><Recommendation><Regular Insulin><Reporting><Research><Risk><Sampling><Sampling Studies><Self Management><Self-Report><Sudden-Onset Diabetes Mellitus><System><T1 DM><T1 diabetes><T1D><T1DM><Technology><Testing><Time><Trust><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><Variant><Variation><active followup><adulthood><aged><analyzing longitudinal><behavior intervention><behavioral intervention><career><chronic disorder><continuous blood glucose monitor><continuous blood sugar monitor><continuous glucose measurement><continuous sugar monitor><data interpretation><developmental><diabetes><diabetes distress><diabetes management><diabetes mellitus management><diabetic management><emotional distress><feeling distress><feeling upset><follow up><follow-up><followed up><followup><glycemic control><hypoglycemic><hypoglycemic episodes><improved><insulin dependent diabetes><insulin dependent type 1><insulin infusion device><insulin infusion pump><insulin pump><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><longitudinal analysis><parent><post intervention><prevent><preventing><psychosocial><psychosocial variables><randomized control trial><recruit><social><tool><type I diabetes><type one diabetes><uptake>
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Julia Parish-Morris

UNIVERSITY OF CALIFORNIA SANTA BARBARA, SANTA BARBARA, CA

Exploratory lead · 10/100
Active award
$94,266
FY 2025

Project Title

Computational Linguistics for Autism-related Social Skills: Assessment for Characterization and Therapy (CLASS-ACT)

Grant Number:

5R03DC021774-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

5/31/2027

Project Abstract

Abstract The goal of this R03 is to leverage computational linguistics to identify sensitive, efficient, and scalable measures of social communication that can be used to inform intervention efforts for transition-aged youth on the autism spectrum. Such measures would yield significant benefits for ...

Research Terms

<ASD><Active Follow-up><Address><Anxiety><Approaches to prevention><Autism><Autistic Disorder><Clinical><Clinical Treatment><Clinical Trials><Collection><Computational Linguistics><Computing Methodologies><Confusion><Confusional State><Consumption><Data><Data Set><Development><Diagnosis><Dimensions><Early Infantile Autism><Employment><Female><Foundations><Friends><Funding><Future><Generalized Growth><Goals><Growth><Heterogeneity><Human><Individual><Infantile Autism><Intake><Intervention><Kanner's Syndrome><Knowledge><Language><Learning><Linguistic><Linguistics><Love><Measures><Mental Confusion><Mental Depression><Modeling><Modern Man><Monitor><NIDCD><National Institute on Deafness and Other Communication Disorders><Outcome><Outcome Assessment><Outcome Measure><Output><Parents><Participant><Patient Self-Report><Pattern><Personalized medical approach><Persons><Phenotype><Pilot Projects><Preparedness><Prevention approach><Process><Protocol><Protocols documentation><Public Health><Publishing><QOL><Quality of life><Randomized, Controlled Trials><Readiness><Research><Same-sex><Sampling><Self-Report><Services><Social Interaction><Social support><Speech><Standardization><Strategic Planning><Subgroup><Techniques><Teen><Teenagers><Testing><Time><Tissue Growth><Treatment Efficacy><Unemployment><Video Recording><Videorecording><Vulnerable Populations><Waiting Lists><Youth><Youth 10-21><active followup><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><adulthood transition><aged><autism spectral disorder><autism spectrum disorder><autistic><autistic adolescent><autistic individuals><autistic people><autistic spectrum disorder><autistic youth><biomarker identification><clinical care><clinical intervention><clinical outcome measures><clinical practice><clinical predictors><clinical therapy><cohort><comparing females and males><comparing women and men><computational methodology><computational methods><computer based method><computer methods><computing method><depression><design><designing><developmental><females compared to males><females compared with males><females versus males><females vs. males><follow up><follow-up><followed up><followup><group intervention><identification of biomarkers><identification of new biomarkers><implementation intervention><impression><improved><individualized approach><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><innovate><innovation><innovative><insight><interest><interpersonal competence><interpersonal competency><intervention efficacy><intervention program><jobless><joblessness><longitudinal data set><longitudinal dataset><male><marker identification><measurable outcome><ontogeny><out of work><outcome measurement><parent><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><personalized approach><personalized health intervention><personalized intervention><pilot study><post intervention><precision approach><precision interventions><precision medicine><precision-based medicine><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prospective><public health relevance><randomized control trial><repetitive behavior><research study><response><sex><skills><social><social communication><social competence><social competency><social expectations><social interventions><social skills><social support network><societal expectations><success><suicidal><suicidality><tailored approach><teen years><teenage><therapeutic efficacy><therapy efficacy><therapy optimization><transition from adolescence to adulthood><transition into adulthood><transition to adulthood><treatment optimization><trial regimen><trial treatment><unemployed><video recording system><vulnerable group><vulnerable individual><vulnerable people><waitlist><women compared to men><women compared with men><women versus men><women vs. men><youth age><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder><♀><♂>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ty Weston Vernon

UNIVERSITY OF CALIFORNIA SANTA BARBARA, SANTA BARBARA, CA

Exploratory lead · 10/100
Active award
$94,266
FY 2025

Project Title

Computational Linguistics for Autism-related Social Skills: Assessment for Characterization and Therapy (CLASS-ACT)

Grant Number:

5R03DC021774-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/1/2024

End Date:

5/31/2027

Project Abstract

Abstract The goal of this R03 is to leverage computational linguistics to identify sensitive, efficient, and scalable measures of social communication that can be used to inform intervention efforts for transition-aged youth on the autism spectrum. Such measures would yield significant benefits for ...

Research Terms

<ASD><Active Follow-up><Address><Anxiety><Approaches to prevention><Autism><Autistic Disorder><Clinical><Clinical Treatment><Clinical Trials><Collection><Computational Linguistics><Computing Methodologies><Confusion><Confusional State><Consumption><Data><Data Set><Development><Diagnosis><Dimensions><Early Infantile Autism><Employment><Female><Foundations><Friends><Funding><Future><Generalized Growth><Goals><Growth><Heterogeneity><Human><Individual><Infantile Autism><Intake><Intervention><Kanner's Syndrome><Knowledge><Language><Learning><Linguistic><Linguistics><Love><Measures><Mental Confusion><Mental Depression><Modeling><Modern Man><Monitor><NIDCD><National Institute on Deafness and Other Communication Disorders><Outcome><Outcome Assessment><Outcome Measure><Output><Parents><Participant><Patient Self-Report><Pattern><Personalized medical approach><Persons><Phenotype><Pilot Projects><Preparedness><Prevention approach><Process><Protocol><Protocols documentation><Public Health><Publishing><QOL><Quality of life><Randomized, Controlled Trials><Readiness><Research><Same-sex><Sampling><Self-Report><Services><Social Interaction><Social support><Speech><Standardization><Strategic Planning><Subgroup><Techniques><Teen><Teenagers><Testing><Time><Tissue Growth><Treatment Efficacy><Unemployment><Video Recording><Videorecording><Vulnerable Populations><Waiting Lists><Youth><Youth 10-21><active followup><adolescent with ASD><adolescent with autism><adolescent with autism spectrum disorder><adolescents on the autism spectrum><adulthood transition><aged><autism spectral disorder><autism spectrum disorder><autistic><autistic adolescent><autistic individuals><autistic people><autistic spectrum disorder><autistic youth><biomarker identification><clinical care><clinical intervention><clinical outcome measures><clinical practice><clinical predictors><clinical therapy><cohort><comparing females and males><comparing women and men><computational methodology><computational methods><computer based method><computer methods><computing method><depression><design><designing><developmental><females compared to males><females compared with males><females versus males><females vs. males><follow up><follow-up><followed up><followup><group intervention><identification of biomarkers><identification of new biomarkers><implementation intervention><impression><improved><individualized approach><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><innovate><innovation><innovative><insight><interest><interpersonal competence><interpersonal competency><intervention efficacy><intervention program><jobless><joblessness><longitudinal data set><longitudinal dataset><male><marker identification><measurable outcome><ontogeny><out of work><outcome measurement><parent><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><personalized approach><personalized health intervention><personalized intervention><pilot study><post intervention><precision approach><precision interventions><precision medicine><precision-based medicine><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prospective><public health relevance><randomized control trial><repetitive behavior><research study><response><sex><skills><social><social communication><social competence><social competency><social expectations><social interventions><social skills><social support network><societal expectations><success><suicidal><suicidality><tailored approach><teen years><teenage><therapeutic efficacy><therapy efficacy><therapy optimization><transition from adolescence to adulthood><transition into adulthood><transition to adulthood><treatment optimization><trial regimen><trial treatment><unemployed><video recording system><vulnerable group><vulnerable individual><vulnerable people><waitlist><women compared to men><women compared with men><women versus men><women vs. men><youth age><youth on the autism spectrum><youth with ASD><youth with autism><youth with autism spectrum disorder><♀><♂>
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Carrie A. Miller

VIRGINIA COMMONWEALTH UNIVERSITY, RICHMOND, VA

Exploratory lead · 10/100
Active award
$89,340
FY 2025

Project Title

Developing a Young Adult-Mediated Intervention to Increase Colorectal Cancer Screening among Rural Screening Age-Eligible Adults

Grant Number:

5R03CA270837-03

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

7/31/2026

Project Abstract

PROJECT SUMMARY Colorectal cancer (CRC) remains the second leading cause of cancer-related death in the United States. Recent studies have highlighted several geographic, primarily rural, “hotspots” for excess CRC incidence and mortality. One driver of these disparities between rural and non-rural p...

Research Terms

<21+ years old><Address><Adult><Adult Children><Adult Daughters><Adult Human><Adult Offspring><Adult Sons><Age><Age Years><Area><Awareness><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Breast Cancer Detection><Breast cancer screening><Breast screening><CRC prevention><CRC screening><Cancer Cause><Cancer Control><Cancer Control Science><Cancer Etiology><Cancers><Cessation of life><Colorectal Cancer><Communication><Conditioning Therapy><Data><Death><Development><Disparities><Disparity><Early Diagnosis><Educational process of instructing><Eligibility><Eligibility Determination><Evidence based intervention><Family><Family member><Feedback><Focus Groups><Foundations><Geography><Goals><Health><Incidence><Individual><Intervention><Knowledge><Malignant Neoplasms><Malignant Tumor><Mediating><Methods><Modeling><Morbidity><Morbidity - disease rate><Parents><Participant><Phase><Population><Pre-Post Tests><Preparedness><Process><Protocol Screening><Qualitative Methods><Randomized><Randomized, Controlled Trials><Readiness><Recommendation><Research><Rural><Rural Community><Rural Population><Rural group><Rural people><Scanning><Screening for cancer><Series><Source><Survey Instrument><Surveys><Teaching><Testing><Time><United States><Work><acceptability and feasibility><adult youth><adulthood><age group><ages><anti-cancer research><arm><behavior intervention><behavioral intervention><cancer prevention><cancer research><colorectal cancer detection><colorectal cancer early detection><colorectal cancer prevention><colorectal cancer screening><design><designing><detect colorectal cancer><developmental><early cancer detection><early detection><geographic disadvantage><geographic disparity><geographic inequality><geographic inequity><geographic location disparity><grandparent><health communication><health literacy><improved><innovate><innovation><innovative><intervention design><intervention refinement><malignancy><mammary cancer detection><mammary screening><math ability><math achievement><math competence><math competency><math proficiency><mathematic ability><mathematic achievement><mathematic compentence><mathematic compentency><mathematic proficiency><mathematical ability><mathematical achievement><mathematical compentence><mathematical compentency><mathematical proficiency><mortality><neoplasm/cancer><novel><number sense><numeracy><open label><open label study><parent><pilot test><prevent colorectal cancer><proficient in math><programs><protective behavior><qualitative reasoning><quantitative literacy><randomisation><randomization><randomized control trial><randomly assigned><recommended screening><response><rural area><rural individual><rural locality><rural location><rural place><rural region><rural setting><screening><screening cancer patients><screening guidelines><screening recommendations><screening uptake><screenings><therapy design><treatment design><trial design><uptake><young adult><young adult age><young adulthood>
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Karsten Lunze

BOSTON MEDICAL CENTER, BOSTON, MA

Exploratory lead · 10/100
Active award
$89,000
FY 2024

Project Title

Community-engaged implementation strategies for acceptance interventions to improve access to care for people with HIV and injection drug use

Grant Number:

5R03DA059341-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/1/2023

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY Various barriers including stigma can limit access to HIV and substance use for people with HIV who inject drugs. Acceptance and Commitment Treatment (ACT) empowers these people to cope with stigma and other care barriers, leading to an increase in health services utilization. ACT is...

Research Terms

<AIDS Virus><Access to Care><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Address><Adoption><Affect><Assess implementation><Caring><Choice Behavior><Communities><Data><Data Set><Dimensions><Dose><Drugs><Epidemic><Evidence based intervention><Funding><Future><Goals><HIV><Harm Minimization><Harm Reduction><Health Services><Health Services Accessibility><Healthcare Delivery><Human Immunodeficiency Viruses><Hybrids><Implementation assessment><Improve Access><Intervention><Intervention Strategies><Interview><LAV-HTLV-III><Link><Lived experience><Lived experiences><Lymphadenopathy-Associated Virus><Medication><Methods><Modality><Modeling><Monitor><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Outcome><Overdose><Participant><Patient Recruitments><Perception><Persons><Pharmaceutical Preparations><Population><Process><Proctor evaluation model><Proctor framework><Proctor multi-level outcomes framework><Proctor multilevel outcomes framework><Proctor process outcomes><Proctor taxonomy><Protocol><Protocols documentation><Psychologist><Publishing><QOC><Quality Control><Quality of Care><Randomized, Controlled Trials><Recommendation><Site><Stigmatization><Structure><Substance Use Disorder><Supervision><Survey Instrument><Surveys><Target Populations><Techniques><Testing><Training><Virus-HIV><Work><access to health services><access to services><access to treatment><accessibility to health services><adherence rate><antiretroviral therapy><antiretroviral treatment><availability of services><behavior change><care access><clinical implementation><community clinic><community engaged intervention><community engagement><community informed intervention><community involvement><community partners><community-based partners><community-partnered intervention><coping><design><designing><drug/agent><effectiveness and implementation trial><effectiveness/implementation hybrid trial><effectiveness/implementation trial><emotion regulation><emotional regulation><empowerment><engagement with communities><evaluate implementation><evaluation of implementation><evidence base><flexibility><flexible><framework by proctor><health and care delivery><health care delivery><health care quality><health delivery systems><health service access><health service use><health service utilization><health services availability><health services delivery><healthcare quality><implementation evaluation><implementation outcomes><implementation research><implementation strategy><improved><injection drug use><interest><intervention design><intervention participants><interventional strategy><meeting><meetings><mindfulness><participant recruitment><proctor conceptual model><proctor implementation><proctor model><psychologic><psychological><randomized control trial><satisfaction><service availability><service gap><social stigma><stigma><strategies for implementation><substance use><substance use and disorder><substance using><therapy design><treatment access><treatment design><treatment group><treatment program>
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Kathryn N Stump

INNOVATION RESEARCH AND TRAINING, INC., DURHAM, NC

Exploratory lead · 10/100
Active award
$87,000
FY 2024

Project Title

The impact of mentor characteristics on mitigating substance use outcomes among children of incarcerated caregivers

Grant Number:

5R03DA056772-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/30/2023

End Date:

8/31/2026

Project Abstract

Abstract Mentoring programs are a common positive youth development intervention that serve children of incarcerated parents (COIP). COIP are a particularly vulnerable population because they are exposed to a multitude of challenges, including family instability, stigmatization, and stress. A growin...

Research Terms

<0-11 years old><12-20 years old><21+ years old><Active Follow-up><Adolescence><Adult><Adult Human><Affective><Age><Alcohol Chemical Class><Alcohols><Approaches to prevention><Attitude><Awareness><Behavioral><Black><Black race><Care Givers><Caregivers><Caring><Characteristics><Child><Child Youth><Childhood><Children (0-21)><Cognition><Data><Data Set><Development><Drug Prescribing><Drug Prescriptions><Effectiveness><Empathy><Evaluation><Exposure to><Face><Family><Future><Generalized Growth><Goals><Groups at risk><Growth><High Prevalence><Hispanic><History><Imprisonment><Intervention><Intervention Strategies><Latine><Latinx><Length><Literature><Logistic Regressions><Marijuana><Measurement><Mentors><Mission><NIDA><National Institute of Drug Abuse><National Institute on Drug Abuse><Outcome><Parents><People at risk><Personality Assessment><Personality Character><Personality Traits><Persons><Persons at risk><Philadelphia><Population><Population Heterogeneity><Populations at Risk><Predictive Factor><Prevention approach><Prevention program><Randomized, Controlled Trials><Recording of previous events><Regression Analyses><Regression Analysis><Regression Diagnostics><Reporting><Research><Risk><Role><Sampling><Screening procedure><Self Efficacy><Series><Social Functioning><Statistical Regression><Stigmatization><Stress><Survey Instrument><Surveys><Survival Analyses><Survival Analysis><Symptoms><Tissue Growth><Training><Trust><Victimization><Vulnerable Populations><Work><Youth><Youth 10-21><active followup><adolescence (12-20)><adulthood><ages><archival data><archived data><data archived><determine efficacy><develop therapy><developmental><diverse populations><early adolescence><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><evaluate efficacy><examine efficacy><experience><faces><facial><follow up><follow-up><followed up><followup><function socially><functioning social><girls><heterogeneous population><histories><improved><incarcerated><incarceration><intervention development><interventional strategy><kids><knowledge base><marihuana><medication prescription><ontogeny><parent><parent award><parent project><pediatric><personality characteristic><population diversity><positive youth development><premature><prematurity><prescribed medication><programs><randomized control trial><reduced substance use><reduction in substance use><screening tools><skills><social role><substance misuse><substance use><substance use reduction><substance using><success><therapy development><treatment development><volunteer><vulnerable group><vulnerable individual><vulnerable people><youngster>
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Jonathan Dreyfuss

JOSLIN DIABETES CENTER, BOSTON, MA

Exploratory lead · 10/100
Active award
$85,500
FY 2025

Project Title

Replication Analysis to Identify Acute Molecular Responses to Exercise that Lead to Chronic Training Adaptations

Grant Number:

1R03AG102038-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/23/2025

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT The Molecular Transducers of Physical Exercise Consortium (MoTrPAC) is tasked with defining the molecular footprint that underlies the immensely beneficial effects of exercise on health. The animal component of MoTrPAC consists of two major studies: one investigating exercis...

Research Terms

<AD dementia><Acute><Address><Adipose tissue><Adult-Onset Diabetes Mellitus><Age><Age Months><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Animals><Body Tissues><Cardiovascular Diseases><Chronic><Chronic Disease><Chronic Illness><Common Rat Strains><Communities><Complex><Data><Data Bases><Data Set><Databases><Development><Diabetes Mellitus><Disease><Disorder><Event><Exercise><Exercise Therapy><Fatty Tissue><Foundations><Future><Genes><Goals><Health><Health Benefit><Health Promotion><Heart><Hour><Individual><Investigation><Ketosis-Resistant Diabetes Mellitus><Kidney><Kidney Urinary System><Knowledge><Lead><Length><Maps><Maturity-Onset Diabetes Mellitus><Mediating><Medical Research><Metabolic><Metabolic syndrome><Methods><Molecular><NIDDM><Network Analysis><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Pathway Analysis><Pb element><Phosphoproteins><Physical Exercise><Physical activity><Physiologic><Physiological><Prevention><Primary Senile Degenerative Dementia><Proteins><Proteome><Proteomics><R-Series Research Projects><R01 Mechanism><R01 Program><Rat><Rats Mammals><Rattus><Recommendation><Regulation><Research Grants><Research Project Grants><Research Projects><Research Resources><Resources><Role><Salutogenesis><Science><Skeletal Muscle><Slow-Onset Diabetes Mellitus><Societies><Stable Diabetes Mellitus><Stimulus><T2 DM><T2D><T2DM><Therapeutic exercise><Time><Tissues><Training><Transducers><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Validation><Voluntary Muscle><Work><adipose><adult onset diabetes><advanced age rats><aged rat><aged rats><ages><cardiovascular disorder><chronic disorder><data base><developmental><diabetes><elderly rats><endurance exercise><exercise intervention><exercise training><exercise treatment><geriatric rats><heavy metal Pb><heavy metal lead><improved><innovate><innovation><innovative><ketosis resistant diabetes><maturity onset diabetes><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><old rats><phospho-proteomics><phosphoproteomics><physical activity intervention><primary degenerative dementia><promoting health><renal><response><senile dementia of the Alzheimer type><sex><social role><stem><subcutaneous><subdermal><therapeutic target><tool><transcriptomics><treated with exercise><type 2 DM><type II DM><type two diabetes><validations><white adipose tissue><yellow adipose tissue>
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LAURIE J GOODYEAR

JOSLIN DIABETES CENTER, BOSTON, MA

Exploratory lead · 10/100
Active award
$85,500
FY 2025

Project Title

Replication Analysis to Identify Acute Molecular Responses to Exercise that Lead to Chronic Training Adaptations

Grant Number:

1R03AG102038-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/23/2025

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT The Molecular Transducers of Physical Exercise Consortium (MoTrPAC) is tasked with defining the molecular footprint that underlies the immensely beneficial effects of exercise on health. The animal component of MoTrPAC consists of two major studies: one investigating exercis...

Research Terms

<AD dementia><Acute><Address><Adipose tissue><Adult-Onset Diabetes Mellitus><Age><Age Months><Alzheimer Type Dementia><Alzheimer disease dementia><Alzheimer sclerosis><Alzheimer syndrome><Alzheimer's><Alzheimer's Disease><Alzheimers Dementia><Animals><Body Tissues><Cardiovascular Diseases><Chronic><Chronic Disease><Chronic Illness><Common Rat Strains><Communities><Complex><Data><Data Bases><Data Set><Databases><Development><Diabetes Mellitus><Disease><Disorder><Event><Exercise><Exercise Therapy><Fatty Tissue><Foundations><Future><Genes><Goals><Health><Health Benefit><Health Promotion><Heart><Hour><Individual><Investigation><Ketosis-Resistant Diabetes Mellitus><Kidney><Kidney Urinary System><Knowledge><Lead><Length><Maps><Maturity-Onset Diabetes Mellitus><Mediating><Medical Research><Metabolic><Metabolic syndrome><Methods><Molecular><NIDDM><Network Analysis><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Pathway Analysis><Pb element><Phosphoproteins><Physical Exercise><Physical activity><Physiologic><Physiological><Prevention><Primary Senile Degenerative Dementia><Proteins><Proteome><Proteomics><R-Series Research Projects><R01 Mechanism><R01 Program><Rat><Rats Mammals><Rattus><Recommendation><Regulation><Research Grants><Research Project Grants><Research Projects><Research Resources><Resources><Role><Salutogenesis><Science><Skeletal Muscle><Slow-Onset Diabetes Mellitus><Societies><Stable Diabetes Mellitus><Stimulus><T2 DM><T2D><T2DM><Therapeutic exercise><Time><Tissues><Training><Transducers><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Validation><Voluntary Muscle><Work><adipose><adult onset diabetes><advanced age rats><aged rat><aged rats><ages><cardiovascular disorder><chronic disorder><data base><developmental><diabetes><elderly rats><endurance exercise><exercise intervention><exercise training><exercise treatment><geriatric rats><heavy metal Pb><heavy metal lead><improved><innovate><innovation><innovative><ketosis resistant diabetes><maturity onset diabetes><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><old rats><phospho-proteomics><phosphoproteomics><physical activity intervention><primary degenerative dementia><promoting health><renal><response><senile dementia of the Alzheimer type><sex><social role><stem><subcutaneous><subdermal><therapeutic target><tool><transcriptomics><treated with exercise><type 2 DM><type II DM><type two diabetes><validations><white adipose tissue><yellow adipose tissue>
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Arnab Kumar Ghosh

WEILL MEDICAL COLL OF CORNELL UNIV, NEW YORK, NY

Exploratory lead · 10/100
Active award
$84,750
FY 2025

Project Title

The Interaction of Public Health Emergencies: Understanding Nation-wide and City-wide Spatiotemporal Dynamics of COVID-19 Transmission in a Warming World

Grant Number:

5R03TR004976-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2024

End Date:

2/28/2027

Project Abstract

Program Summary I am an early-stage investigator and recent KL2 scholar who has used econometric and spatiotemporal meth- ods to examine the propagation of C-19 in vulnerable populations. The focus of this R03 is to build on this work to examine the interaction between two devastating public health ...

Research Terms

<2019 novel corona virus><2019 novel coronavirus><2019-nCoV><21+ years old><Accounting><Admission><Admission activity><Adult><Adult Human><Adverse Experience><Adverse event><Affect><Age><Air><American><Area><Award><Behavior><COVID associated morbidity><COVID crisis><COVID epidemic><COVID induced morbidity><COVID morbidity><COVID pandemic><COVID related morbidity><COVID-19><COVID-19 associated morbidity><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 induced morbidity><COVID-19 morbidity><COVID-19 pandemic><COVID-19 period><COVID-19 predisposition><COVID-19 public health crisis><COVID-19 related morbidity><COVID-19 related risk><COVID-19 risk><COVID-19 risk factor><COVID-19 susceptibility><COVID-19 transmission><COVID-19 virus><COVID-19 virus transmission><COVID-19 vulnerability><COVID-19 years><COVID19 virus><CV-19><Censuses><Cessation of life><Characteristics><Chronic Disease><Chronic Illness><Cities><Climate><Clinical><CoV-2><CoV2><Communicable Diseases><Coronaviridae><Coronavirus><Coronavirus Infectious Disease 2019><Coronavirus disease 2019 predisposition><Coronavirus disease 2019 susceptibility><Coronavirus disease 2019 vulnerability><County><Crowding><Data><Data Sources><Death><Economically Deprived Population><Environment><Event><Federal Government><Foundations><Frequencies><Future><Groups at risk><Health><Hospital Admission><Hospitalization><Household><Humidity><Impoverished><Individual><Individuals from minority><Individuals of minority><Infectious Disease Epidemiology><Infectious Diseases><Infectious Disorder><Infectious Epidemiology><Institution><Intervention><Investigators><Measures><Medical><Meteorological Climate><Methods><Minority><Minority Groups><Minority People><Minority Population><Minority individual><Modeling><Morbidity><Morbidity - disease rate><NCATS><NHLBI><NIAID><NIEHS><NIH><National Center for Advancing Translational Sciences><National Government><National Heart, Lung, and Blood Institute><National Institute of Allergy and Infectious Disease><National Institute of Environmental Health Sciences><National Institutes of Health><Orthocoronavirinae><Outcome><Pathway interactions><Patients><People at risk><Persons at risk><Physiologic><Physiological><Population><Populations at Risk><Poverty><Predisposed to COVID-19><Predisposed to SARS-CoV-2><Predisposed to Severe acute respiratory syndrome coronavirus 2><Prevalence><Public Health><Quasi-experiment><Quasi-experimental analysis><Quasi-experimental approach><Quasi-experimental design><Quasi-experimental methods><Quasi-experimental research><Quasi-experimental study><Quasi-experimental technique><Research><Research Personnel><Research Resources><Researchers><Resources><Risk><SARS corona virus 2><SARS-CO-V2><SARS-COVID-2><SARS-CoV-2><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-CoV-2 predisposition><SARS-CoV-2 susceptibility><SARS-CoV-2 transmission><SARS-CoV-2 vulnerability><SARS-CoV2><SARS-associated corona virus 2><SARS-associated coronavirus 2><SARS-coronavirus-2><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><SARS-related corona virus 2><SARS-related coronavirus 2><SARSCoV2><Scientist><Services><Severe Acute Respiratory Coronavirus 2><Severe Acute Respiratory Distress Syndrome CoV 2><Severe Acute Respiratory Distress Syndrome Corona Virus 2><Severe Acute Respiratory Distress Syndrome Coronavirus 2><Severe Acute Respiratory Syndrome CoV 2><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe Acute Respiratory Syndrome-associated coronavirus 2><Severe Acute Respiratory Syndrome-related coronavirus 2><Severe acute respiratory syndrome associated corona virus 2><Severe acute respiratory syndrome coronavirus 2><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Severe acute respiratory syndrome coronavirus 2 predisposition><Severe acute respiratory syndrome coronavirus 2 susceptibility><Severe acute respiratory syndrome coronavirus 2 vulnerability><Severe acute respiratory syndrome related corona virus 2><Severities><Socioeconomically disadvantaged><Southwest U.S.><Southwest US><Southwestern United States><Specific qualifier value><Specified><Sunlight><Temperature><Testing><Translating><United States National Institutes of Health><Vaccination><Vulnerable Populations><Weather><Work><Wuhan coronavirus><adulthood><aged group><aged groups><aged individual><aged individuals><aged people><aged person><aged persons><aged population><aged populations><ages><aging population><chronic disorder><climate and health><climate change><climate health><climate-related health><climatic><climatic changes><co-morbid><co-morbidity><cohort><comorbidity><corona virus><coronavirus disease 2019><coronavirus disease 2019 associated morbidity><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 induced morbidity><coronavirus disease 2019 morbidity><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease 2019 related morbidity><coronavirus disease 2019 risk><coronavirus disease 2019 risk factor><coronavirus disease 2019 transmission><coronavirus disease 2019 virus><coronavirus disease 2019 virus transmission><coronavirus disease associated morbidity><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease induced morbidity><coronavirus disease morbidity><coronavirus disease pandemic><coronavirus disease related morbidity><coronavirus disease-19><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><coronavirus disease-19 virus><coronavirus infectious disease-19><design><designing><econometrics><economically deprived group><economically deprived people><economically disadvantaged group><economically disadvantaged individual><economically disadvantaged people><economically disadvantaged population><ethnic minority><ethnic minority status><evidence base><experience><extreme heat><extreme weather><future pandemic><global climate change><hCoV19><health equity><improved><indexing><mortality><nCoV2><next pandemic><old age><pandemic disease preparedness><pandemic planning><pandemic preparedness><pandemic readiness><pathway><population aging><predisposed to Coronavirus disease 2019><programs><public health emergency><racial minority><risk associated with COVID-19><risk factor associated with COVID-19><risk factor related to COVID-19><risk related to COVID-19><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><severe acute respiratory syndrome coronavirus 2 transmission><simulation><socio-economic><socio-economic disadvantage><socio-economically><socio-economically disadvantaged><socio-economically underprivileged><socioeconomic disadvantage><socioeconomically><socioeconomically underprivileged><socioeconomics><spatial and temporal><spatial temporal><spatiotemporal><sun light><susceptible to COVID-19><susceptible to Coronavirus disease 2019><susceptible to SARS-CoV-2><susceptible to Severe acute respiratory syndrome coronavirus 2><theories><tool><translational clinician><translational physician><transmitted COVID-19><transmitted SARS-CoV-2><transmitted coronavirus disease 2019><transmitted severe acute respiratory syndrome coronavirus 2><underclass><viral pandemic><vulnerable group><vulnerable individual><vulnerable people><vulnerable to COVID-19><vulnerable to Coronavirus disease 2019><vulnerable to SARS-CoV-2><vulnerable to Severe acute respiratory syndrome coronavirus 2>
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Howard J Worman

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 10/100
Active award
$82,250
FY 2025

Project Title

Using mouse models to dissect the roles of ZMPSTE24 and prelamin A in accelerated aging

Grant Number:

5R03AG088752-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

6/30/2026

Project Abstract

PROJECT SUMMARY Accelerated aging disorders can provide critical insights into aspects of physiological aging. A subset of accelerated aging disorders, including Hutchinson-Gilford progeria syndrome (HGPS) and mandibuloacral dysplasia type B (MAD-B), are characterized by accumulation of farnesylated...

Research Terms

<Acceleration><Aging><Amino Acid Substitution><Amino Acids><Arginine><Automobile Driving><Cell Components><Cell Nucleus><Cell Structure><Cellular Structures><DNA mutation><Data><Defect><Disease><Disorder><Dysplasia><Enzyme Gene><Enzymes><Fibroblast Intermediate Filament Proteins><Future><Genes><Genetic Change><Genetic defect><Genetic mutation><Grant><Human><Hutchinson-Gilford Disease><Hutchinson-Gilford Syndrome><Intermediate Filament Proteins><L-Arginine><Lamin A><Lamin Type A><Lead><Learning><Length><Length of Life><Leucine><Longevity><Mediating><Metallopeptidases><Metalloproteases><Metalloproteinases><Mice><Mice Mammals><Modeling><Modern Man><Murine><Mus><Mutant Strains Mice><Mutation><Neonatal><Nuclear Lamina><Nucleus><Outcome><Pathogenicity><Patients><Pb element><Phenotype><Physiologic><Physiological><Point Mutation><Premature Senility Syndrome><Process><Progeria><Proteins><R-Series Research Projects><R01 Mechanism><R01 Program><Reaction><Research Grants><Research Project Grants><Research Projects><Research Resources><Residual><Residual state><Resources><Role><Severities><Site><Syndrome><Testing><Time><Variant><Variation><Zinc><Zn element><accelerated aging><accelerated biological age><accelerated biological aging><age acceleration><aging associated disease><aging associated disorders><aging related disease><aging related disorders><aminoacid><disease associated with aging><disease of aging><disorder of aging><disorders associated with aging><disorders related to aging><driving><dyscrasia><farnesylation><genome mutation><heavy metal Pb><heavy metal lead><insight><lamin A precursor><life span><lifespan><loss of function><mouse model><mouse mutant><murine model><natural aging><normal aging><normative aging><prelamin A><social role>
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Jewel Elias Crasta

OHIO STATE UNIVERSITY, Columbus, OH

Exploratory lead · 10/100
Active award
$78,750
FY 2025

Project Title

Neural biomarkers of sensory symptoms in autism

Grant Number:

5R03MH134135-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

7/1/2024

End Date:

6/30/2026

Project Abstract

Project Summary Sensory symptoms are a core diagnostic feature of autism and cause substantial functional impairment. Auditory processing is one of the most affected domains and is hypothesized to play a role in the socio- communicative and restricted/repetitive behavior symptoms in autism. Measurem...

Research Terms

<ASD><Address><Affect><Age><Attention><Auditory><Autism><Autistic Disorder><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Biological Markers><Brain><Brain Nervous System><Childhood><Clinical><Clinical Management><Clinical Trials><Conditioning Therapy><Data><Diagnostic><Drug Therapy><EEG><Early Infantile Autism><Economic Burden><Electroencephalogram><Electroencephalography><Encephalon><Equation><Evidence based intervention><Foundations><Functional impairment><Future><Goals><Impairment><Infantile Autism><Intervention><Kanner's Syndrome><Knowledge><Language><Measurement><Measures><Mediating><Methods><Modeling><Motor><Parents><Patient Self-Report><Performance><Pharmacological Treatment><Pharmacotherapy><Process><Regulation><Reporting><Role><Self-Report><Sensory><Social Behavior><Symptoms><Testing><Time><Validation><Work><adult with ASD><adult with autism><adult with autism spectrum disorder><adults on the autism spectrum><adults on the spectrum><ages><assess effectiveness><auditory processing><auditory stimulus><autism biomarker><autism marker><autism spectral disorder><autism spectrum disorder><autistic adult><autistic children><autistic individuals><autistic people><autistic spectrum disorder><behavior intervention><behavioral intervention><bio-markers><biologic marker><biomarker><brain behavior><children on the autism spectrum><children with ASD><children with autism><children with autism spectrum disorder><determine effectiveness><drug intervention><drug treatment><effectiveness assessment><effectiveness evaluation><evaluate effectiveness><evidence base><examine effectiveness><functional outcomes><improved><individuals on the autism spectrum><individuals on the spectrum><individuals with ASD><individuals with autism><individuals with autism spectrum disorder><innovate><innovation><innovative><neural><neural mechanism><neuromechanism><novel><parent><pediatric><peer><people on the autism spectrum><people with ASD><people with autism><people with autism spectrum disorder><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><potential biological marker><potential biomarker><public health relevance><repetitive behavior><response><sensory mechanism><social><social role><sociobehavior><sociobehavioral><validations>
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Tali Elfassy

UNIVERSITY OF MIAMI SCHOOL OF MEDICINE, CORAL GABLES, FL

Exploratory lead · 10/100
Active award
$76,750
FY 2025

Project Title

Validation of the PREVENT Risk Score for Stroke Among US Hispanic Adults

Grant Number:

1R03NS142916-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2025

End Date:

7/31/2027

Project Abstract

ABSTRACT Stroke is the fifth leading cause of death in the US but disproportionately impacts ethnic minority populations. Among the over 62 million Hispanic people in the US, stroke represents the third leading cause of death among Hispanic men and the fourth among Hispanic women. In 2023, the Ameri...

Research Terms

<21+ years old><ASCVD><Accounting><Address><Adult><Adult Human><Age><American Heart Association><Analgesic Management><Apoplexy><Atherosclerosis><Atherosclerotic Cardiovascular Disease><Black><Black race><Brain Vascular Accident><Brain Vascular Disorders><Calibration><Cardiac Diseases><Cardiac Disorders><Cardiovascular Diseases><Caribbean><Caribbean Sea Region><Caribbean region><Cause of Death><Central American><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Disease><Cerebrovascular Disorders><Cerebrovascular Stroke><Chicago><Cholesterol><Cities><Clinical><Cognitive Discrimination><Collection><Cuba><Data><Development><Discrimination><Disease Outcome><Dominican Republic><Enrollment><Equation><Ethnic Origin><Ethnicity><Event><Female><HCHS/SOL Study><HCHS/SOL cohort><Health behavior><Heart Diseases><Heterogeneity><High Prevalence><Hispanic><Hispanic Community Health Study/Study of Latinos><Hispanic Females><Hispanic Populations><Hispanic Women><Hispanic group><Hispanic individual><Hispanic male><Hispanic men><Hispanic people><Hispanics><History><Hypertension><Immigration><Individual><Intracranial Vascular Diseases><Intracranial Vascular Disorders><Life Cycle><Life Cycle Stages><Measures><Medication Management><Mission><Modeling><NIH><NINDS><National Institute of Neurological Diseases and Stroke><National Institute of Neurological Disorders and Stroke><National Institutes of Health><Nervous System Diseases><Nervous System Disorder><Neurologic Disorders><Neurological Disorders><Non-Hispanic><Nonhispanic><Not Hispanic or Latino><Outcome><Participant><Performance><Persons><Pharmacologic Management><Population><Predicting Risk><Prevalence><Prevention><Preventive><Primary Prevention><Puerto Rico><Race><Races><Recording of previous events><Reporting><Research><Research Design><Risk><Risk Assessment><Risk Estimate><Risk Factors><Sampling><Socio-economic status><Socioeconomic Status><South American><Stroke><Stroke prevention><Study Type><Study of Latinos><Time><United States National Institutes of Health><Validation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Visit><West Indies Region><Work><adjudication><adjudicative process and procedure><adulthood><ages><atheromatosis><atherosclerotic disease><atherosclerotic vascular disease><base><bases><biological sex as a modifier><brain attack><brain vascular disease><brain vascular dysfunction><burden of disease><burden of illness><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cerebral vascular accident><cerebral vascular disease><cerebral vascular dysfunction><cerebrovascular accident><cerebrovascular dysfunction><cohort><community health study><comparing females and males><comparing women and men><computer based prediction><developmental><disease burden><enroll><ethnic minority group><ethnic minority individual><ethnic minority people><ethnic minority population><females compared to males><females compared with males><females versus males><females vs. males><flexibility><flexible><forecasting risk><health related behavior><heart disorder><high blood pressure><high risk><histories><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><incidence of stroke><indexing><intracranial vascular dysfunction><life course><male><medication therapy management><neurological disease><novel><predict risk><predict risks><predicted risk><predicted risks><predicting risks><predictive modeling><predictive risk><predicts risk><prevent stroke><racial><racial background><racial origin><recruit><research study><risk for stroke><risk of stroke><risk prediction><risk predictions><sex><sex as a biological factor><sex as a biological measure><sex as a biological risk factor><sex as a biological variable><sex as a biological variance><sex as a biologically significant variable><sex as a fundamental variable><social><social deprivation><social health determinants><socio-economic position><socioeconomic position><stroke event><stroke incidence><stroke risk><stroked><strokes><study design><validation studies><validations><women compared to men><women compared with men><women versus men><women vs. men><♀><♂>
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Sulie L. Chang

SETON HALL UNIVERSITY, SOUTH ORANGE, NJ

Exploratory lead · 10/100
Active award
$76,624
FY 2025

Project Title

Investigation of cold plasma for healing alcohol-induced tissue injury

Grant Number:

5R03AA031535-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/20/2024

End Date:

8/31/2026

Project Abstract

Abstract: Binge drinking of alcohol beverages hinders tissue repair and amplifies the susceptibility to infection. The prevalence as well as the risks associated with binge drinking poses a significant concern in the United States. Binge drinking impairs the three key phases of wound healing: infla...

Research Terms

<(TNF)-α><3-D><3-Dimensional><3D><Abbreviations><Absolute ethanol><Active Oxygen><Address><Afferent Neurons><Alcohol Chemical Class><Alcohol Drinking><Alcohol Intoxication><Alcohol consumption><Alcoholic Intoxication><Alcohols><Antiseptics><Atmosphere><Attention><Award><B cell differentiation factor><B cell stimulating factor 2><B-Cell Differentiation Factor><B-Cell Differentiation Factor-2><B-Cell Stimulatory Factor-2><BCDF><BSF-2><BSF2><Beta Cadherin-Associated Protein><Beta Proprotein Interleukin 1><Beta-1 Catenin><Beverages><Biocompatible Materials><Bioinformatics><Biological Response Modifier Therapy><Biological Therapy><Biomaterials><Blood Alcohol Content><Blood Neutrophil><Blood Plasma><Blood Polymorphonuclear Neutrophil><Blood alcohol level measurement><Body Tissues><CCL2><CCL2 gene><CSIF><CSIF-10><CUL-2><CXCL2><CXCL2 gene><Cachectin><Cancer Treatment><Cell Communication and Signaling><Cell Signaling><Chemicals><Chemokine, CC Motif, Ligand 2><Chemokine, CXC Motif, Ligand 2><Chemotactic Cytokines><Clinical><Collagen><Consumption><Cytokine Synthesis Inhibitory Factor><Dehydrogenases><Dermal><Dose><Drunkenness><ELISA><ETOH><Endothelial Cells><Enzyme-Linked Immunosorbent Assay><Erythrocuprein><EtOH drinking><EtOH intoxication><EtOH use><Ethanol><Ethyl Alcohol><Exhibits><Exposure to><F344 Rats><Female><Fibroblasts><Fischer Rats><Food and Drug Administration><GRO Protein, Beta><GRO2><GRO2 Oncogene><GROb><GROβ><GSSG><Gases><Gene Expression><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Genes><Glia><Glial Cells><Glutathione><Glutathione Disulfide><Grain Alcohol><Grant><Growth><Growth Agents><Growth Factor><Growth Substances><H and E><HPGF><Hair Follicle><Hair follicle structure><Hematoxylin and Eosin><Hematoxylin and Eosin Staining Method><Hemocuprein><Hepatocyte-Stimulating Factor><History><Homologous Chemotactic Cytokines><Hour><Human><Hybridoma Growth Factor><IACUC><IFN-beta 2><IFNB2><IL-1 beta><IL-1 β><IL-1-b><IL-10><IL-1β><IL-6><IL1-Beta><IL1-β><IL10><IL10A><IL1B Protein><IL1F2><IL1β><IL6 Protein><Immunofluorescence><Immunofluorescence Immunologic><Impaired tissue repair><Impaired wound healing><Impairment><In Vitro><Inbred CDF Rats><Inbred F344 Rats><Inbred Fischer 344 Rats><Inbred Fisher 344 Rats><Infection><Infection prevention><Inflammation><Inflammatory><Inflammatory Response><Injury><Innate Immune System><Institutional Animal Care and Use Committee><Intercrines><Interleukin 10 Precursor><Interleukin 1beta><Interleukin-1 beta><Interleukin-10><Interleukin-1β><Interleukin-6><Intracellular Communication and Signaling><Investigation><Kolliker's reticulum><Laboratories><Local Anti-Infective Agents><MCAF><MCP-1><MCP1><MGI-2><MIP-2A><MIP2-alpha><MIP2A><MIP2α><Macrophage><Macrophage-Derived TNF><Malignant Cell><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Marrow Neutrophil><Mediating><Medical><Medicine><Meta-Analysis><Methods><Methylcarbinol><Modeling><Modern Man><Molecular><Monocyte Chemoattractant Protein-1><Monocyte Chemotactic Protein-1><Monocyte Chemotactic and Activating Factor><Monocyte Chemotactic and Activating Protein><Monocyte Chemotactive and Activating Factor><Monocyte Secretory Protein JE><Monocyte-Derived TNF><Myeloid Differentiation-Inducing Protein><Mφ><NF-E2 protein><NF-E2 transcription factor><NFE2 protein><Natural regeneration><Network Analysis><Neuroglia><Neuroglial Cells><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Nitrogen><Non-neuronal cell><Nonneuronal cell><O element><O2 element><Organoids><Outcome Study><Oxidation-Reduction><Oxidized Glutathione><Oxidoreductase><Oxidoreductase Gene><Oxygen><Oxygen Radicals><Oxygenases><PRO2286><Pathway Analysis><Pathway interactions><Patients><Periodicals><Phase><Physiology><Plasma><Plasma Serum><Plasmacytoma Growth Factor><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Predisposition><Preinterleukin 1 Beta><Prevalence><Prevent infection><Pro-Oxidants><Production><Proliferating><Property><Proteins Growth Factors><Reactive Nitrogen Species><Reactive Oxygen Species><Recording of previous events><Redox><Reductases><Regeneration><Research><Reticuloendothelial System, Serum, Plasma><Risk><Risk Factors><Role><SCYA2><SCYB2><SIS cytokines><Sensory Neurons><Signal Pathway><Signal Transduction><Signal Transduction Systems><Signaling><Skin><Skin graft><Small Inducible Cytokine A2><Small Inducible Cytokine Subfamily B, Member 2><Solid><Staining method><Stains><Superoxide Dismutase><Surgical Wound Infection><Susceptibility><System><TNF><TNF A><TNF Alpha><TNF gene><TNF-α><TNFA><TNFα><Testing><Therapeutic><Thick><Thickness><Time><Tissue Growth><Tissues><Topical Anti-Infective Agents><Transcript Expression Analyses><Transcript Expression Analysis><Tumor Necrosis Factor><Tumor Necrosis Factor-alpha><USFDA><United States><United States Food and Drug Administration><Wound Infection><Wound Repair><Wound models><abnormal tissue repair><acute stress><alcohol effect><alcohol exposed><alcohol exposure><alcohol ingestion><alcohol intake><alcohol misuse><alcohol product use><alcohol use><alcoholic beverage consumption><alcoholic drink intake><allogenic skin graft><analyze gene expression><angiogenesis><anti-cancer therapy><beta cat><beta catenin><binge alcohol consumption><binge drinking><bio-informatics network><bioinformatics network><biological material><biological signal transduction><biological therapeutic><biological treatment><biologically based therapeutics><biotherapeutics><biotherapy><blood alcohol concentration><blood alcohol level><cancer cell><cancer therapy><cancer-directed therapy><chemoattractant cytokine><chemokine><clinical applicability><clinical application><clinical practice><combat><cytocuprein><cytokine><delayed wound healing><differential expression><differentially expressed><enzyme linked immunoassay><episodic drinking><ethanol consumption><ethanol drinking><ethanol effect><ethanol exposed><ethanol exposure><ethanol ingestion><ethanol intake><ethanol intoxication><ethanol misuse><ethanol product use><ethanol use><exposed to alcohol><exposed to ethanol><exposure to alcohol><exposure to ethanol><gamma-L-Glu-L-Cys-Gly><gamma-L-Glutamyl-L-Cysteinylglycine><gene expression analysis><gene expression assay><healing><hiPSC><histories><human iPS><human iPSC><human induced pluripotent cell><human induced pluripotent stem cells><human inducible pluripotent stem cells><human inducible stem cells><improved><induced human pluripotent stem cells><infected wound><injuries><injury to tissue><interest><interferon beta 2><ionization><keratinocyte><knowledge base><macrophage inflammatory protein 2><male><nerve cement><neutrophil><new approaches><novel approaches><novel strategies><novel strategy><nuclear factor-erythroid 2><ontogeny><oxidation reduction reaction><pathogen><pathway><periodic><periodical><regenerate><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><regeneration healing><regenerative><regenerative healing><response><self organization><simulation><social role><stem cell organoids><stem cell-derived organoids><surgical site infection><three dimensional><tissue injury><tissue regeneration><tissue regrowth><tissue renewal><tissue repair><tissue specific regeneration><tool><transcriptional differences><transcriptional profiling><treat wound><unhealthy alcohol use><wound closure><wound healing><wound healing models><wound management><wound recovery><wound resolution><wound therapeutics><wound therapy><wound treatment><β-GRO protein><β-catenin><♀><♂>
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Koenraad Van Doorslaer

UNIVERSITY OF ARIZONA, TUCSON, AZ

Exploratory lead · 10/100
Active award
$75,013
FY 2025

Project Title

Developing tools to study HPV16 in oropharyngeal tissues

Grant Number:

1R03AI187892-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/15/2024

End Date:

10/31/2026

Project Abstract

Abstract Human papillomaviruses (HPVs) contribute to 5% of global cancer cases, with HPV-associated oropharyngeal cancers now surpassing cervical cancers in the United States, representing an epidemic. Notably, HPV16 is the leading cause of oropharyngeal cancers. Following infection, HPV maintains i...

Research Terms

<Address><Area><Assay><Bioassay><Biological><Biological Assay><Body Tissues><Cancer Genes><Cancer-Promoting Gene><Cancers><Cell Body><Cell Culture Techniques><Cell Differentiation><Cell Differentiation process><Cell Function><Cell Isolation><Cell Line><Cell Physiology><Cell Process><Cell Segregation><Cell Separation><Cell Separation Technology><CellLine><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cellular Transformation><Cervical Cancer><Cervix Cancer><Complement><Complement Proteins><DNA><DNA Integration><DNA Replication><DNA Synthesis><DNA biosynthesis><Data><Deoxyribonucleic Acid><Development><Differential Display><Drug resistance><Epidemic><Epidemiological data><Epidemiology data><Epithelial Cells><Equilibrium><Exhibits><G-418><G418><Gene variant><Genome><HPV><HPV + oropharyngeal carcinoma><HPV 16><HPV 18><HPV mediated oropharynx cancer><HPV oncogene><HPV oropharyngeal cancer><HPV positive><HPV positive oropharyngeal cancer><HPV positive oropharynx cancer><HPV related oropharyngeal cancer><HPV related oropharyngeal carcinoma><HPV(+)><HPV+><HPV+ OPC><HPV+ oropharyngeal cancer><HPV-16><HPV-18><HPV-OPC><HPV-associated oropharyngeal cancer><HPV-driven oropharyngeal cancer><HPV-related OPC><HPV-related oropharyngeal cancer><HPV16><HPV18><Host Factor><Host Factor Protein><Human><Human Papilloma Virus><Human Papillomavirus><Human papilloma viral oncogene><Human papilloma virus type 16><Human papilloma virus type 18><Human papillomavirus 16><Human papillomavirus 18><Human papillomavirus driven oropharyngeal cancer><Human papillomavirus related oropharyngeal carcinoma><Human papillomavirus type 16><Human papillomavirus type 18><Human papillomavirus- related oropharyngeal cancer><Human papillomavirus-associated oropharyngeal cancer><Increase lifespan><Infection><Infectious Human Wart Virus><Integration Host Factors><Life Cycle><Life Cycle Stages><Malignant Cervical Neoplasm><Malignant Cervical Tumor><Malignant Neoplasm of the Cervix><Malignant Neoplasms><Malignant Oropharyngeal Neoplasm><Malignant Oropharyngeal Tumor><Malignant Tumor><Malignant Tumor of the Cervix><Malignant Tumor of the Cervix Uteri><Malignant Uterine Cervix Neoplasm><Malignant Uterine Cervix Tumor><Malignant neoplasm of cervix uteri><Methods><Mission><Mitotic><Modeling><Modern Man><Molecular><NIH><National Institutes of Health><Oncogenes><Oncogenic><Oropharnyx Cancers><Oropharyngeal><Oropharyngeal Cancer><Oropharyngeal Carcinoma><Oropharynx><Oropharynx Cancer><Oropharynx Carcinoma><Oropharynxs><Phenotype><Physiologic><Physiological><Plasmids><Process><Productivity><Property><Proteins><Recovery><Replication Origin><Replication Process><Replication-Associated Process><Reporter><Reproducibility><Research><Research Support><Resistance><Role><Strains Cell Lines><Subcellular Process><Testing><Tissues><Tonsil><Tonsillectomy><Transforming Genes><Tumorigenicity><United States><United States National Institutes of Health><Uterine Cervix Cancer><Variant><Variation><Viral><Viral Gene Products><Viral Gene Proteins><Viral Genome><Viral Oncogene><Viral Proteins><Virus Replication><allelic variant><antibiotic G 418><balance><balance function><biologic><boost longevity><cell culture><cell cultures><cell sorting><cellular differentiation><complementation><cultured cell line><developmental><differential display technique><drug resistant><elongating the lifespan><enhance longevity><epidemiologic data><extend life span><extend lifespan><extend longevity><foster longevity><genetic variant><genomic variant><human papilloma virus 16><human papilloma virus 18><human papilloma virus oncogene><human papillomaviral oncogene><human papillomavirus +><human papillomavirus mediated oropharynx cancer><human papillomavirus oncogene><human papillomavirus positive><human papillomavirus positive oropharyngeal cancer><human papillomavirus positive oropharyngeal carcinoma><human papillomavirus positive oropharynx carcinoma><human papillomavirus+ oropharyngeal cancer><improve lifespan><improve longevity><improved><insight><life course><lifespan extension><mRNA Differential Displays><malignancy><malignant oropharynx neoplasm><malignant oropharynx tumor><metaplastic cell transformation><neoplasm/cancer><novel><oral pharyngeal><ori Region><presence of HPV><presence of human papillomavirus><pressure><prolong lifespan><prolong longevity><promote lifespan><promote longevity><resistance to Drug><resistant><resistant to Drug><social role><success><support longevity><tissue culture><tonsillar><tool><type 16 Human papilloma virus><type 16 Human papillomavirus><viral DNA><viral multiplication><viral replication><virus DNA><virus genome><virus multiplication><virus protein><wart virus>
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KENNETH L MONSON

UTAH STATE HIGHER EDUCATION SYSTEM--UNIVERSITY OF UTAH, SALT LAKE CITY, UT

Exploratory lead · 10/100
Active award
$74,836
FY 2025

Project Title

Tissue Softening in Traumatic Brain Injury

Grant Number:

5R03NS137098-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/15/2024

End Date:

4/30/2027

Project Abstract

Traumatic brain injury (TBI) is a devastating cause of death and disability. Progression of non-fatal cases of TBI often leaves patients at increased risk for subsequent injury and disease. Improved understanding of the mechanisms of TBI is fundamental to improving strategies for both prevention and...

Research Terms

<(4D) flow MRI><21+ years old><4-D MR imaging><4-D MRI><4-D flow MR imaging><4-D flow MRI><4-D flow imaging><4-D flow magnetic resonance imaging><4-D magnetic resonance imaging><4D MR imaging><4D MRI><4D flow MR imaging><4D flow MRI><4D flow imaging><4D flow magnetic resonance imaging><4D magnetic resonance imaging><Accelerometer><Acquired brain injury><Adult><Adult Human><Animal Model><Animal Models and Related Studies><Animals><Anisotropy><Autopsy><BBB permeabilization><BBB permeable><Biological Markers><Bleeding><Blood><Blood Reticuloendothelial System><Blood Vessels><Body Tissues><Brain><Brain Injuries><Brain Nervous System><Brain Trauma><Cause of Death><Cerebrovascular system><Cerebrum><Characteristics><Data><Development><Diagnosis><Disease><Disorder><Dropsy><Edema><Elements><Encephalon><Euthanasia><Evaluation><Event><Family suidae><Head><Hemorrhage><Histology><Histopathology><Hydrops><Image><Injury><Investigation><Isotropy><MR Imaging><MR Tomography><MRI><MRIs><MTBI><Magnetic Resonance Elastography><Magnetic Resonance Imaging><Maps><Mechanics><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Mercy Killing><Modeling><Motion><NMR Imaging><NMR Tomography><Nuclear Magnetic Resonance Imaging><Patients><Physiologic><Physiological><Pigs><Predisposition><Prevention><Process><Property><Protocol><Protocols documentation><Recovery><Research><Risk><Role><Rupture><Severities><Skull><Stretching><Structure><Suidae><Susceptibility><Swine><Techniques><Time><Tissues><Trauma><Traumatic Brain Injury><Validation><Zeugmatography><accelerometry><activity monitor><activity tracker><adulthood><axon damage><axon injury><axonal damage><axonal injury><bio-markers><biologic marker><biomarker><blood loss><blood vessels in the brain><blood-brain barrier permeabilization><blood-brain barrier permeable><bloodbrain barrier permeabilization><bloodbrain barrier permeable><brain blood vessels><brain damage><brain tissue><brain vasculature><brain-injured><cerebral><cerebral artery><cerebral blood vessel><cerebral vasculature><cerebrovascular vessels><cerebrovasculature><cranium><density><developmental><disability><experience><experiment><experimental research><experimental study><experiments><four dimensional MR imaging><four dimensional MRI><four dimensional flow><four dimensional magnetic resonance imaging><imaging><improved><individual patient><injuries><insight><kinematic model><kinematics><mechanic><mechanical><mild TBI><mild brain trauma><mild traumatic brain injury><model of animal><necropsy><novel><porcine><postmortem><response><social role><suid><tool><traumatic brain damage><validations><vascular>
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Prabaha Sikder

CLEVELAND STATE UNIVERSITY, CLEVELAND, OH

Exploratory lead · 10/100
Active award
$74,250
FY 2025

Project Title

Bioengineering of Customized Exosomes as a Cell-free Therapy for Volumetric Muscle Loss Injuries Proposal

Grant Number:

5R03EB036096-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

8/1/2024

End Date:

7/31/2026

Project Abstract

Project Summary/Abstract Volumetric Muscle Loss (VML) is the most devastating and chronic musculoskeletal injury in which a substantial amount of muscle is lost due to trauma or surgery and can be life-threatening. Sadly, the current standard of care, which includes surgical transplantation of allog...

Research Terms

<Accidents><Active Follow-up><Adipose tissue><Affect><Allografting><Amputation><Assay><Bioassay><Biogenesis><Biological Assay><Biological Function><Biological Process><Biomedical Engineering><Cell Body><Cell Therapy><Cells><Chronic><Collaborations><Complication><Defect><Development><Dimensions><Engineering><Exhibits><Extremities><Fatty Tissue><Fibrosis><Fire - disasters><Fires><Foundations><Future><Genes><Goals><Immune><Immunes><Immunoblotting><Immunohistochemistry><Immunohistochemistry Cell/Tissue><Immunohistochemistry Staining Method><Impairment><Inflammation><Injury><Life><Lifelong disability><Limb structure><Limbs><Mediating><Medicine><Mesenchymal Progenitor Cell><Mesenchymal Stem Cells><Mesenchymal progenitor><Mesenchymal stromal/stem cells><MicroRNAs><Morbidity><Morbidity - disease rate><Morphology><Muscle><Muscle Cells><Muscle Tissue><Musculoskeletal><Myocytes><Non-Trunk><Ontology><Operative Procedures><Operative Surgical Procedures><Origin of Life><Outcome><Pain><Painful><Parents><Pathway interactions><Patients><Permanent disability><Physiatric Procedure><Physical Medicine Procedure><Physical Therapeutics><Physical therapy><Physiotherapy><Pilot Projects><Position><Positioning Attribute><Quantitative RTPCR><Quantitative Reverse Transcriptase PCR><RNA Seq><RNA sequencing><RNAseq><Regenerative Medicine><Research><Role><Signal Pathway><Site><Skeletal Muscle><Small RNA><Sports><Surgical><Surgical Interventions><Surgical Procedure><Symptoms><Testing><Therapeutic><Tissue Engineering><Transfection><Transmission Electron Microscopy><Transplantation Surgery><Trauma><Treatment Efficacy><Universities><Voluntary Muscle><Western Blotting><Western Immunoblotting><active followup><adipose><bio-engineered><bio-engineers><bioengineered tissue><bioengineering><biological engineering><cell based intervention><cell mediated intervention><cell mediated therapies><cell-based therapeutic><cell-based therapy><cellular therapeutic><cellular therapy><design><designing><determine efficacy><developmental><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><engineered tissue><evaluate efficacy><examine efficacy><exosome><experience><extracellular vesicles><falls><fire><fire fighter><fire services><firefighter><follow up><follow-up><followed up><followup><healing><infection rate><injuries><injury of musculoskeletal system (disorder)><injury of musculoskeleted system><insight><intervention efficacy><medical college><medical schools><mesenchymal stromal cell><mesenchymal stromal progenitor cells><mesenchymal-derived stem cells><miRNA><muscle regeneration><muscular><musculoskeletal injury><musculoskeletal trauma><myogenesis><nano><nano particle><nano-sized particle><nanoparticle><nanosized particle><parent><pathway><pilot study><preconditioning><primary outcome><protein blotting><qRTPCR><rate of infection><regenerate new tissue><regenerate tissue><regenerating damaged tissue><regenerating tissue><scaffold><scaffolding><school of medicine><serious burns><severe burns><social role><standard of care><surgery><therapeutic agent development><therapeutic development><therapeutic efficacy><therapy efficacy><tissue regeneration><tissue regrowth><tissue renewal><tissue specific regeneration><transcriptome sequencing><transcriptomic sequencing><volumetric muscle loss><white adipose tissue><yellow adipose tissue>
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URSZULA T IWANIEC

OREGON STATE UNIVERSITY, CORVALLIS, OR

Exploratory lead · 10/100
Active award
$74,250
FY 2025

Project Title

Effects of alcohol on bone remodeling balance in male and female non-human primates and humans

Grant Number:

5R03AA032072-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/17/2024

End Date:

8/31/2026

Project Abstract

PROJECT SUMMARY Chronic heavy alcohol consumption contributes to high rates of low trauma fractures in middle-aged and elderly populations, especially men. However, low trauma fracture rates in chronic alcohol abusers exceed levels predicted by age, sex, and bone mineral density, suggesting that al...

Research Terms

<Accidents><Age><Alcohol Chemical Class><Alcohol Drinking><Alcohol abuse><Alcohol consumption><Alcohols><Animal Model><Animal Models and Related Studies><Architecture><Biopsy><Body Tissues><Bone Density><Bone Mineral Density><Bone remodeling><Cancellous bone><Chronic><Complex><Dose><Economics><Elderly><Engineering / Architecture><Equilibrium><EtOH abuse><EtOH drinking><EtOH use><Exhibits><Fatigue><Female><Fracture><Funding><Goals><Heavy Drinking><Human><Individual><Intervention><Lack of Energy><Libraries><Life Style><Lifestyle><Lumbar Vertebrae><M mulatta><M. mulatta><Macaca><Macaca mulatta><Macaca rhesus><Macaque><Machine Learning><Mediating><Modern Man><Monkeys><Morbidity><Morbidity - disease rate><NHP models><NIH><National Institutes of Health><Organ><Osteopenia><Physiology><Population><Porosity><Process><R24><Research><Research Resources><Resources><Rhesus Macaque><Rhesus Monkey><Risk Factors><Site><Skeleton><Sudden Death><Systems Analyses><Systems Analysis><Testing><Tissues><Trauma><United States National Institutes of Health><access to alcohol><adult youth><advanced age><ages><alcohol abuser><alcohol access><alcohol accessibility><alcohol availability><alcohol co-abuse><alcohol co-morbidity><alcohol comorbidity><alcohol effect><alcohol ingestion><alcohol intake><alcohol problem><alcohol product use><alcohol use><alcohol use disorder><alcoholic beverage consumption><alcoholic drink intake><balance><balance function><bone><bone fracture><bone health><bone loss><bone mass><bone quality><bone turnover><chronic EtOH drinking><chronic alcohol consumption><chronic alcohol drinking><chronic alcohol ingestion><chronic alcohol use><chronic ethanol consumption><chronic ethanol drinking><chronic ethanol ingestion><co-morbid><co-morbidity><comorbidity><compact bone><cortical bone><density><drink heavily><drinking><drinking behavior><economic><ethanol abuse><ethanol accessibility><ethanol availability><ethanol consumption><ethanol drinking><ethanol effect><ethanol ingestion><ethanol intake><ethanol product use><ethanol use><ethanol use disorder><excessive alcohol consumption><excessive alcohol ingestion><excessive alcohol intake><excessive drinking><excessive ethanol ingestion><extreme drinking><geriatric><hazardous alcohol use><heavy alcohol use><human female><human male><life-style factor><lifestyle factors><lumbar vertebra bone structure><machine based learning><male><men><mid life><mid-life><middle age><middle aged><midlife><model of animal><mortality><non-human primate><nonhuman primate><nonhuman primate models><prevent><preventing><problem alcohol use><problem drinking><problematic alcohol consumption><problematic alcohol use><repair><repaired><response><senior citizen><sex><skeletal><skeletons><social><substantia spongiosa><substantia trabecularis><tibia><tissue archive><trabecular bone><young adult><young adult age><young adulthood><♀><♂>
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Nektarios Barabutis

UNIVERSITY OF LOUISIANA AT MONROE, MONROE, LA

Exploratory lead · 10/100
Active award
$72,500
FY 2025

Project Title

Synthetic Somatostatin Analogs Protect Against Endothelial Barrier Dysfunction

Grant Number:

5R03AI176433-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/23/2024

End Date:

3/31/2027

Project Abstract

Summary Endothelial barrier dysfunction (EBD) has been associated with crucial lung injury ((e.g. acute respiratory distress syndrome (ARDS)) and deaths in the Intensive Care Units. Approved medicine that specifically targets EBD does not exist, hence the development of efficient medical countermeas...

Research Terms

<ARDS><ATF6><ATF6 gene><ATP-protein phosphotransferase><Acromegaly><Activating Transcription Factor 6><Acute Lung Injury><Acute Pulmonary Injury><Acute Respiratory Distress><Acute Respiratory Distress Syndrome><Adult ARDS><Adult RDS><Adult Respiratory Distress Syndrome><Affect><Applications Grants><Blood><Blood Reticuloendothelial System><Blood Vessels><Body Tissues><Bovine Species><Cattle><Cell Communication and Signaling><Cell Signaling><Cellular Matrix><Cellular injury><Cessation of life><Chiro-Inositol><Clinic><Cytoskeletal System><Cytoskeleton><Da Nang Lung><Data><Death><Development><Disease><Disorder><Dysfunction><ER stress><Electrolytes><Endoplasmic Reticulum><Endothelial Cells><Endothelium><Enzyme Gene><Enzymes><Epithelium><Ergastoplasm><Experimental Models><Exposure to><Extensive Disease><FDA approved><FITC-dextran><Functional disorder><GHRH><GRH><GTP Phosphohydrolases><GTPases><Generalized Disease><Grant Proposals><Growth Hormone><Growth Hormone 1><Growth Hormone-Releasing Factor><Growth Hormone-Releasing Hormone><Guanosine Triphosphate Phosphohydrolases><Guanosinetriphosphatases><Human><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><Immune Interferon><In Vitro><Inappropriate GH Secretion Syndrome (Acromegaly)><Inappropriate Growth Hormone Secretion Syndrome (Acromegaly)><Inflammation><Inflammatory><Injury><Inositol><Intensive Care Units><Interferon Gamma><Interferon Type II><Intracellular Communication and Signaling><Intramuscular><Investigation><Kinase Family Gene><Kinases><Knowledge><Left><Liquid substance><Lung damage><Medicine><Mesoinositol><Mice><Mice Mammals><Modern Man><Murine><Mus><Neuroendocrine Neoplasm><Neuroendocrine Tumors><Non-Polyadenylated RNA><Octreotide><Oral><Outcome><Permeability><Phosphatases><Phosphohydrolases><Phosphomonoesterases><Phosphoric Monoester Hydrolases><Phosphotransferase Gene><Phosphotransferases><Physiopathology><Pituitary Growth Hormone><Protein Kinase><Proteins><Publications><Publishing><RNA><RNA Gene Products><Regulation><Ribonucleic Acid><Role><Scientific Publication><Sepsis and ARDS><Shock Lung><Short interfering RNA><Signal Transduction><Signal Transduction Systems><Signaling><Small Interfering RNA><Somatocrinin><Somatoliberin><Somatotropin><Somatotropin Hypersecretion Syndrome (Acromegaly)><Somatotropin-Releasing Hormone><Stiff lung><Stimulus><Techniques><Testing><Tissues><Transphosphorylases><Widespread Disease><acromegalic features><acute respiratory distress syndrome caused by sepsis><antagonism><antagonist><biological signal transduction><bovid><bovine><cell damage><cell injury><cellular damage><cow><damage to cells><design><designing><developmental><endoplasmic reticulum stress><fluid><fluorescein isothiocyanate dextran><fluoresceinthiocarbamoyl dextrans><glycogen synthase a kinase><guanosinetriphosphatase><hydroxyalkyl protein kinase><in vivo><inflammatory lung disease><inhibitor><injuries><injury to cells><intracellular skeleton><kifunensine><lFN-Gamma><liquid><lung injury><lung microvascular endothelial cells><lung vascular endothelial cells><medical countermeasure><mouse model><murine model><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><pathophysiology><pharmacologic><phosphorylase b kinase kinase><protective effect><protein folding><pulmonary arterial endothelial cell><pulmonary artery endothelial cell><pulmonary damage><pulmonary injury><pulmonary microvascular endothelial cells><pulmonary tissue damage><pulmonary tissue injury><pulmonary vascular endothelial cells><repair><repaired><response><response biomarker><response markers><sensor><sepsis ARDS><sepsis acute respiratory distress syndrome><sepsis and acute respiratory distress syndrome><sepsis associated acute respiratory distress syndrome><sepsis induced ARDS><sepsis induced acute respiratory distress syndrome><sepsis related acute respiratory distress syndrome><siRNA><social role><somatostatin analog><somatotropic hormone><subcutaneous><subdermal><vascular><wet lung>
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Patrick Hibbard

CHESTNUT HEALTH SYSTEMS, INC., BLOOMINGTON, IL

Exploratory lead · 10/100
Active award
$66,400
FY 2025

Project Title

Adult Drug Treatment Courts and Their Communities: A Rigorous Examination of Drug Court Impact on Community Overdose Rates and How Social and Structural Determinants of Health Play a Role

Grant Number:

1R03DA062754-01

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2025

End Date:

4/30/2027

Project Abstract

With over 100,000 drug overdose deaths annually, substance use disorder (SUD) amounts to a national crisis. Research has demonstrated a connection between public health issues, like SUD, and public safety. Given the community-level impact of the opioid epidemic, especially for fatal overdoses, commu...

Research Terms

<21+ years old><Access to Care><Address><Adult><Adult Human><Affect><Age><Automobile Driving><Cause of Death><Censuses><Cessation of life><Characteristics><Collaborations><Communities><County><Crime><Data><Data Bases><Data Set><Databases><Death><Decision Making><Disparities><Disparity><Drug Courts><Drug Evaluation><Drug Evaluation Studies><Drug Therapy><Drug usage><Drugs><Ecologic Systems><Ecological Systems><Ecosystem><Effectiveness><Event><Funding><Goals><HEAL Initiative><Health Services Accessibility><Helping End Addiction Long-term><Helping to End Addiction Long-term><Impoverished><Imprisonment><Individual><Influentials><Investigation><Investigators><Investments><Legal system><Link><Lived experience><Lived experiences><Medication><Mental Health><Mental Hygiene><Methods><Mission><Modeling><NIDA><NIH><National Institute of Drug Abuse><National Institute on Drug Abuse><National Institutes of Health><Opiate Addiction><Opiate Dependence><Opiates><Opioid><Outcome><Overdose><Participant><Perception><Persons><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Play><Policies><Policy Making><Population><Poverty><Provider><Psychological Health><Public Defender><Public Health><Publishing><Quasi-experiment><Quasi-experimental analysis><Quasi-experimental approach><Quasi-experimental design><Quasi-experimental methods><Quasi-experimental research><Quasi-experimental study><Quasi-experimental technique><Race><Races><Recovery><Research><Research Design><Research Personnel><Research Resources><Researchers><Resources><Role><SAMHSA><Safety><Sampling><Services><Specialty><Specific qualifier value><Specified><Speed><Structure><Study Type><Substance Abuse and Mental Health Services Administration><Substance Use Disorder><System><Time><United States National Institutes of Health><United States Substance Abuse and Mental Health Services Administration><Vital Statistics><Work><access to health services><access to services><access to treatment><accessibility to health services><addiction><addictive disorder><adulthood><ages><availability of services><care access><career><community factor><community-level factor><court><data base><data harmonization><depository><disparate effect><disparate impact><disparate result><driving><drug intervention><drug treatment><drug use><drug/agent><harmonized data><health service access><health services availability><improved><incarcerated><incarceration><inequitable effect><inequitable impact><inequitable outcome><interest><longitudinal database><medical specialties><multiple data sources><non-medical opioid use><nonmedical opioid use><opiate consumption><opiate crisis><opiate drug use><opiate intake><opiate misuse><opiate use><opioid addiction><opioid consumption><opioid crisis><opioid dependence><opioid dependent><opioid drug use><opioid epidemic><opioid intake><opioid misuse><opioid use><outcome disparities><outcome inequality><outcome inequity><overdose death><overdose fatalities><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><prevent><preventing><programs><racial><racial background><racial origin><recidivism><repository><residence><residential building><residential site><rural area><rural location><rural region><rurality><service availability><sex><social><social determinants><social health determinants><social role><socio-economic><socio-economically><sociodeterminant><socioeconomically><socioeconomics><structural determinants><structural factors><structural health determinants><study design><substance use><substance use and disorder><substance use treatment><substance using><tool><treatment access><treatment services><unequal effect><unequal impact><unequal outcome><violent crime>
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Kathryn Holroyd

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 10/100
Active award
$48,031
FY 2025

Project Title

Systemic and Central Nervous System Vasculopathy in Acute HIV and After Early Antiretroviral Therapy

Grant Number:

5R03NS141698-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/5/2024

End Date:

8/31/2026

Project Abstract

ABSTRACT Over 38 million people worldwide are living with HIV, and the non-communicable complications of HIV infection are a significant global health concern. People with HIV (PWH) have an increased risk of cerebrovascular disease, cognitive impairment, brain atrophy, and white matter disease despi...

Research Terms

<AIDS Virus><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Acute><Affect><After Care><After-Treatment><Aftercare><Apoplexy><Applications Grants><Arteriosclerotic Dementia><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Vessels><Brain><Brain Nervous System><Brain Vascular Accident><Brain Vascular Disorders><CNS Nervous System><COVID-19><CV-19><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Central Nervous System><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Disease><Cerebrovascular Disorders><Cerebrovascular Stroke><Chronic><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cohort Studies><Concurrent Studies><Coronavirus Infectious Disease 2019><Data><Development><Diagnosis><Disease><Disease Progression><Disorder><Disturbance in cognition><Drug usage><Dysfunction><Early Intervention><Early identification><Encephalon><Endothelium><Enrollment><Event><Functional disorder><Funding><Future><Goals><Grant Proposals><HIV><HIV Infections><HIV Seronegativities><HIV Seronegativity><HIV negative><HTLV-III Infections><HTLV-III Seronegativities><HTLV-III Seronegativity><HTLV-III-LAV Infections><Health><Health system><Heart Vascular><Heterogeneity><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Image><Impaired cognition><Infection><Intervention><Intracranial Vascular Diseases><Intracranial Vascular Disorders><Knowledge><LAV-HTLV-III><Lipids><Long-term cohort><Longitudinal cohort><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Lymphadenopathy-Associated Virus><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measurable><Measurement><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><NMR Imaging><NMR Tomography><Neuraxis><Neurologic><Neurological><Neuronal Injury><Nuclear Magnetic Resonance Imaging><Participant><Peripheral><Persons><Physiopathology><Pilot Projects><Population><Preventative intervention><Process><Prospective Studies><Research><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Scientist><Stroke><Testing><Thailand><Time><Training><Translational Research><Translational Science><Vascular Dementia><Vascular Diseases><Vascular Disorder><Viral><Viral Diseases><Virus Diseases><Virus-HIV><White Matter Disease><White Matter Hyperintensity><Work><Zeugmatography><antiretroviral therapy><antiretroviral treatment><bio-markers><biologic marker><biomarker><biomarker identification><blood vessel disorder><brain atrophy><brain attack><brain health><brain vascular disease><brain vascular dysfunction><brain vascular health><cardiovascular disorder><cerebral atrophy><cerebral vascular accident><cerebral vascular disease><cerebral vascular dysfunction><cerebrovascular accident><cerebrovascular contributions to dementia><cerebrovascular dysfunction><cerebrovascular health><circulatory system><co-infection><co-morbid><co-morbidity><cognitive assessment><cognitive dysfunction><cognitive loss><cognitive testing><cohort><coinfection><comorbidity><compare to control><comparison control><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><cortical atrophy><cost><cost effective><design><designing><developmental><disease duration><disease length><drug use><early biomarkers><early detection biomarkers><early detection markers><endothelial dysfunction><enroll><global health><high risk><identification of biomarkers><identification of new biomarkers><illness length><imaging><imaging biomarker><imaging marker><imaging-based biological marker><imaging-based biomarker><imaging-based marker><immunoneurology><improved><indexing><intervention for prevention><intracranial vascular dysfunction><marker identification><neurocognitive disorder><neurocognitive test><neuroimmunology><neuron injury><novel><pathophysiology><pilot study><post treatment><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prevent><preventing><prevention intervention><preventional intervention strategy><preventive intervention><prospective><reactive hyperemia><risk for stroke><risk of stroke><stroke risk><stroked><strokes><translation research><translational investigation><vascular><vascular contributions in dementia><vascular contributions to dementia><vascular dysfunction><vascular related dementia><vasculopathy><viral infection><virus infection><virus-induced disease>
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Kathryn Holroyd

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 10/100
Active award
$23,220
FY 2025

Project Title

Systemic and Central Nervous System Vasculopathy in Acute HIV and After Early Antiretroviral Therapy

Grant Number:

3R03NS141698-02S1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

9/5/2024

End Date:

8/31/2026

Project Abstract

ABSTRACT Over 38 million people worldwide are living with HIV, and the non-communicable complications of HIV infection are a significant global health concern. People with HIV (PWH) have an increased risk of cerebrovascular disease, cognitive impairment, brain atrophy, and white matter disease despi...

Research Terms

<AIDS Virus><Acceleration><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Acute><Affect><After Care><After-Treatment><Aftercare><Apoplexy><Applications Grants><Arteriosclerotic Dementia><Biological Markers><Blood><Blood Reticuloendothelial System><Blood Vessels><Brain><Brain Nervous System><Brain Vascular Accident><Brain Vascular Disorders><CNS Nervous System><COVID-19><CV-19><Cardiovascular><Cardiovascular Body System><Cardiovascular Diseases><Cardiovascular Organ System><Cardiovascular system><Central Nervous System><Cerebral Stroke><Cerebrovascular Apoplexy><Cerebrovascular Disease><Cerebrovascular Disorders><Cerebrovascular Stroke><Chronic><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Cohort Studies><Concurrent Studies><Coronavirus Infectious Disease 2019><Data><Development><Diagnosis><Disease><Disease Progression><Disorder><Disturbance in cognition><Drug usage><Dysfunction><Early Intervention><Early identification><Encephalon><Endothelium><Enrollment><Event><Functional disorder><Funding><Future><Goals><Grant Proposals><HIV><HIV Infections><HIV Seronegativities><HIV Seronegativity><HIV negative><HTLV-III Infections><HTLV-III Seronegativities><HTLV-III Seronegativity><HTLV-III-LAV Infections><Health><Health system><Heart Vascular><Heterogeneity><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><Image><Impaired cognition><Infection><Intervention><Intracranial Vascular Diseases><Intracranial Vascular Disorders><Knowledge><LAV-HTLV-III><Lipids><Long-term cohort><Longitudinal cohort><Low-resource area><Low-resource community><Low-resource environment><Low-resource region><Low-resource setting><Lymphadenopathy-Associated Virus><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Measurable><Measurement><Measures><Medical><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><NMR Imaging><NMR Tomography><Neuraxis><Neurologic><Neurological><Neuronal Injury><Nuclear Magnetic Resonance Imaging><Participant><Peripheral><Persons><Physiopathology><Pilot Projects><Population><Preventative intervention><Process><Prospective Studies><Research><Resource-constrained area><Resource-constrained community><Resource-constrained environment><Resource-constrained region><Resource-constrained setting><Resource-limited area><Resource-limited community><Resource-limited environment><Resource-limited region><Resource-limited setting><Resource-poor area><Resource-poor community><Resource-poor environment><Resource-poor region><Resource-poor setting><Risk><Scientist><Stroke><Testing><Thailand><Time><Training><Translational Research><Translational Science><Vascular Dementia><Vascular Diseases><Vascular Disorder><Viral><Viral Diseases><Virus Diseases><Virus-HIV><White Matter Disease><White Matter Hyperintensity><Work><Zeugmatography><antiretroviral therapy><antiretroviral treatment><bio-markers><biologic marker><biomarker><biomarker identification><blood vessel disorder><brain atrophy><brain attack><brain health><brain vascular disease><brain vascular dysfunction><brain vascular health><cardiovascular disorder><cerebral atrophy><cerebral vascular accident><cerebral vascular disease><cerebral vascular dysfunction><cerebrovascular accident><cerebrovascular contributions to dementia><cerebrovascular dysfunction><cerebrovascular health><circulatory system><co-infection><co-morbid><co-morbidity><cognitive assessment><cognitive dysfunction><cognitive loss><cognitive testing><cohort><coinfection><comorbidity><compare to control><comparison control><coronavirus disease 2019><coronavirus disease-19><coronavirus infectious disease-19><cortical atrophy><cost><cost effective><design><designing><developmental><disease duration><disease length><drug use><early biomarkers><early detection biomarkers><early detection markers><endothelial dysfunction><enroll><global health><high risk><identification of biomarkers><identification of new biomarkers><illness length><imaging><imaging biomarker><imaging marker><imaging-based biological marker><imaging-based biomarker><imaging-based marker><immunoneurology><improved><indexing><intervention for prevention><intracranial vascular dysfunction><marker identification><neurocognitive disorder><neurocognitive test><neuroimmunology><neuron injury><novel><pathophysiology><pilot study><post treatment><predictive biological marker><predictive biomarkers><predictive marker><predictive molecular biomarker><prevent><preventing><prevention intervention><preventional intervention strategy><preventive intervention><prospective><reactive hyperemia><risk for stroke><risk of stroke><stroke risk><stroked><strokes><translation research><translational investigation><vascular><vascular contributions in dementia><vascular contributions to dementia><vascular dysfunction><vascular related dementia><vasculopathy><viral infection><virus infection><virus-induced disease>
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Judith M Ford

VETERANS AFFAIRS MED CTR SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 10/100
Active award
$0
FY 2025

Project Title

CSRD Research Career Scientist Award Application

Grant Number:

5IK6CX002519-03

Activity Code:

IK6

Mechanism:

Other

Agency:

VA

Start Date:

4/1/2022

End Date:

3/31/2029

Project Abstract

Dr. Ford is an established investigator in neuroscience and psychiatry, with a PhD in neuroscience and life-long appointments in mental health/psychiatry. She uses electroencephalography (EEG) and functional magnetic resonance imaging (fMRI), to investigate the neurobiology of schizophrenia (SZ) and...

Research Terms

<1st degree relative><Address><Advocate><American><Anesthesiology><Animals><Anxiety><Appointment><Asthma><Attention><Auditory><Auditory Hallucination><Award><Behavior><Behavioral Sciences><Biologic Psychiatry><Biological Psychiatry><Blood><Blood Reticuloendothelial System><Blood Vessels><Body System><Brain><Brain Nervous System><Brain imaging><Bronchial Asthma><COVID complications><COVID related complications><COVID survivors><COVID-19><COVID-19 affected><COVID-19 complications><COVID-19 consequence><COVID-19 effect><COVID-19 impact><COVID-19 impacted><COVID-19 infection survivors><COVID-19 long hauler><COVID-19 related complications><COVID-19 survivors><CV-19><Cancers><Cell Communication and Signaling><Cell Signaling><Cerebellum><Chronic><Clinical><Clinical Medical Sciences><Clinical Medicine><Clinical Trials><Cognition><Cognitive><Cognitive deficits><Collaborations><Congresses><Conscious><Consciousness><Coronavirus Infectious Disease 2019><Delusions><Diagnostic><Diet><Distress><Doctor of Philosophy><Dysfunction><EEG><Educational process of instructing><Electroencephalogram><Electroencephalography><Elements><Emotions><Encephalon><Environment><Esthesia><Event><Family><First Degree Relative><Foundations><Functional MRI><Functional Magnetic Resonance Imaging><Functional disorder><Funding><General Radiology><Grant><Group Meetings><Hallucinations><Human><Hypertension><International><Intracellular Communication and Signaling><Investigators><Judgment><Ketones><Leadership><Learning><Life><Link><Long COVID><Long COVID-19><Long coronavirus disease><Long coronavirus disease 2019><Lung><Lung Respiratory System><MR Imaging><MR Tomography><MRI><MRIs><Magnetic Resonance Imaging><Major Depressive Disorder><Malignant Neoplasms><Malignant Tumor><Medical Imaging, Magnetic Resonance / Nuclear Magnetic Resonance><Medicine><Mental Depression><Mental Health><Mental Hygiene><Mentors><Metabolic syndrome><Methods><Mind><Mindfulness Approach><Mindfulness Therapy><Mindfulness Training><Mindfulness Treatment><Mindfulness-based Approach><Mindfulness-based Therapy><Mindfulness-based Training><Mindfulness-based Treatment><Modern Man><Morbidity><Morbidity - disease rate><Motor><NIH><NMR Imaging><NMR Tomography><National Institutes of Health><Neurobiology><Neurosciences><Nuclear Magnetic Resonance Imaging><Obesity><Organ System><Parietal><Participant><Patients><Perception><Persons><Ph.D.><PhD><Phase><Physicians><Physiopathology><Pons><Pons Cerebelli><Pons Varolii><Pontine><Pontine structure><Population><Psychiatrist><Psychiatry><Psychological Health><Psychological Tests><Psychologist><Psychoses><Qualifying><Radiologic Health><Radiological Health><Radiology><Radiology Specialty><Research><Research Personnel><Researchers><Residual><Residual state><Review Committee><Role><SARS-CoV-2 survivors><Sampling><Schizophrenia><Schizophrenic Disorders><Scientist><Sensation><Sensory><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Smoking><Societies><Stimulus><Structure><Symptoms><System><Talents><Teaching><Thinking><Translating><United States National Institutes of Health><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Veterans><Work><Youth><Youth 10-21><Zeugmatography><adiposity><after COVID-19 infection><after SARS-CoV-2 infection><after SARS-CoV2 infection><after infection by SARS-CoV-2><after severe acute respiratory distress syndrome CoV-2 infection><biological signal transduction><biomarker identification><brain visualization><career><chronic COVID><chronic COVID-19><chronic effect of COVID-19><chronic novel coronavirus disease 2019><clinical depression><clinical risk><clinical significance><clinically significant><cognitive defects><college><collegiate><complications due to COVID-19><coronavirus disease 2019><coronavirus disease 2019 consequence><coronavirus disease 2019 effect><coronavirus disease 2019 impact><coronavirus disease 2019 long hauler><coronavirus disease-19><coronavirus disease-19 impact><coronavirus infectious disease-19><corpulence><cost><deficit syndrome><dementia praecox><depression><diets><disability><editorial><experience><fMRI><fMRI/EEG><following COVID-19 infection><following SARS-CoV-2 infection><following SARS-CoV2 infection><following infection by SARS-CoV-2><following severe acute respiratory distress syndrome CoV-2 infection><functional magnetic resonance imaging/electroencephalography><high blood pressure><high risk><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><identification of biomarkers><identification of new biomarkers><image-based method><imaging method><imaging modality><information processing><keto diet><ketogenic diet><life span><lifespan><long haul COVID><long haul COVID-19><long haul coronavirus disease><long haul coronavirus disease 2019><long hauler><long-hauler COVID><long-hauler COVID-19><long-hauler coronavirus disease 2019><long-hauler syndrome><long-term COVID><long-term COVID-19><long-term consequence of severe acute respiratory distress syndrome-cov-2 infection><long-term consequences of COVID-19><long-term consequences of SARS-CoV-2 infection><long-term consequences of coronavirus disease-19><long-term coronavirus disease><long-term coronavirus disease 2019><long-term effects of COVID-19><long-term effects of coronavirus disease-19><long-term health consequences of COVID-19><long-term health consequences of SARS-CoV2 infection><long-term impact of COVID-19><long-term impact of SARS-CoV-2 infection><major depression><major depression disorder><malignancy><marker identification><meeting><meetings><member><mindfulness><mortality><neoplasm/cancer><neural><neural imaging><neural network><neuro-imaging><neurobiological><neuroimaging><neurological imaging><neuropsychopharmacology><operation><operations><pathophysiology><persistent COVID-19><post COVID syndrome><post COVID-19 syndrome><post SARS-CoV-2 infection><post acute COVID syndrome><post acute COVID-19><post acute COVID-19 syndrome><post acute SARS-CoV-2><post acute coronavirus disease 2019><post acute coronavirus disease 2019 syndrome><post acute coronavirus disease syndrome><post acute severe acute respiratory syndrome coronavirus 2><post coronavirus disease 2019 syndrome><post coronavirus disease syndrome><post-acute phases of COVID-19><previous COVID-19 infection><previous SARS-CoV-2 infection><previous SARS-CoV2 infection><previous severe acute respiratory distress syndrome CoV-2 infection><prior COVID-19 infection><prior SARS-CoV-2 infection><prior SARS-CoV2 infection><prior severe acute respiratory distress syndrome CoV-2 infection><programs><prolonged COVID-19 symptoms><radiologist><recruit><response><ruminate><rumination><ruminative><schizophrenia spectrum><schizophrenia spectrum disorder><schizophrenic><social role><survive COVID-19><survive SARS-CoV-2><thoughts><vascular><virtual><youth age>
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Elizabeth Goldberg

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 8/100
Career award
$214,604
FY 2024

Project Title

GAPcare II: The Geriatric Acute & Post-acute Care Coordination Program for Fall Prevention in the Emergency Department

Grant Number:

3K76AG059983-05S2

Activity Code:

K76

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2019

End Date:

11/30/2025

Project Abstract

PROJECT SUMMARY Falls by older adults are often predictable and preventable, yet there is a notable lack of research evaluating interventions to reduce the occurrence of recurrent falls in older adult Emergency Department (ED) patients. Dr. Goldberg’s Beeson K76 project GAPcare II, the Geriatric Ac...

Research Terms

<Accident and Emergency department><Acute><Address><Aging><Analgesic Management><Apple watch><Award><Care Givers><Caregivers><Caring><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Data><Data Analyses><Data Analysis><Disturbance in cognition><Drugs><ED care><ED patient><ED visit><ER care><ER patient><ER visit><Elderly><Emergency Care><Emergency Department><Emergency Department care><Emergency Department patient><Emergency Medicine><Emergency Room care><Emergency Room patient><Emergency care visit><Emergency department visit><Emergency health care><Emergency healthcare><Emergency hospital visit><Emergency medical care><Emergency room><Emergency room visit><Epidemiologist><Epidemiology><Fall prevention><Future><Goals><Health Policy><Health Services><Health Services Evaluation><Health Services Research><Healthy People 2020><Home><Impaired cognition><Injury><Intervention><Intervention Strategies><Investigation><Investigators><Leadership><Life><Measures><Medical Care Research><Medical Rehabilitation><Medication><Medication Management><Mentors><Mentorship><Methods><Modeling><Out-patients><Outcome><Outpatients><Patients><Pattern><Pharmaceutical Preparations><Pharmacies><Pharmacists><Pharmacologic Management><Pharmacy facility><Physicians><Pilot Projects><Policies><Preventative intervention><Protocol><Protocols documentation><Public Health><Qualitative Research><Randomized, Controlled Trials><Recurrence><Recurrent><Rehabilitation><Rehabilitation therapy><Research><Research Personnel><Research Resources><Researchers><Resources><Safety><Scientist><Specialist><Technology><Testing><Training><Work><acute care><advanced age><applewatch><care as usual><care coordination><career><cognitive dysfunction><cognitive loss><collaborative approach><coordinating care><data interpretation><digital health><disability><drug/agent><epidemiologic><epidemiological><fall risk><falls><field based data><field learning><field study><field test><geriatric><health care policy><healthcare policy><high risk><homes><injuries><intervention for prevention><interventional strategy><medication therapy management><mortality><multidisciplinary><older adult><older adulthood><physical therapist><physiotherapist><pilot study><prevent><preventing><preventing falls><prevention intervention><preventional intervention strategy><preventive intervention><programs><randomized control trial><rehab therapy><rehabilitative><rehabilitative therapy><senior citizen><services research><treatment as usual><usability><usual care>
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Elizabeth Goldberg

UNIVERSITY OF COLORADO DENVER, Aurora, CO

Exploratory lead · 8/100
Career award
$11,412
FY 2024

Project Title

GAPcare II: The Geriatric Acute & Post-acute Care Coordination Program for Fall Prevention in the Emergency Department

Grant Number:

3K76AG059983-05S1

Activity Code:

K76

Mechanism:

Other Research-Related

Agency:

NIH

Start Date:

9/1/2019

End Date:

11/30/2025

Project Abstract

PROJECT SUMMARY Falls by older adults are often predictable and preventable, yet there is a notable lack of research evaluating interventions to reduce the occurrence of recurrent falls in older adult Emergency Department (ED) patients. Dr. Goldberg’s Beeson K76 project GAPcare II, the Geriatric Ac...

Research Terms

<Accident and Emergency department><Acute><Address><Aging><Analgesic Management><Apple watch><Award><Care Givers><Caregivers><Caring><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Data><Data Analyses><Data Analysis><Disturbance in cognition><Drugs><ED care><ED patient><ED visit><ER care><ER patient><ER visit><Elderly><Emergency Care><Emergency Department><Emergency Department care><Emergency Department patient><Emergency Medicine><Emergency Room care><Emergency Room patient><Emergency care visit><Emergency department visit><Emergency health care><Emergency healthcare><Emergency hospital visit><Emergency medical care><Emergency room><Emergency room visit><Epidemiologist><Epidemiology><Fall prevention><Future><Goals><Health Policy><Health Services><Health Services Evaluation><Health Services Research><Healthy People 2020><Home><Impaired cognition><Injury><Intervention><Intervention Strategies><Investigation><Investigators><Leadership><Life><Measures><Medical Care Research><Medical Rehabilitation><Medication><Medication Management><Mentors><Mentorship><Methods><Modeling><Out-patients><Outcome><Outpatients><Patients><Pattern><Pharmaceutical Preparations><Pharmacies><Pharmacists><Pharmacologic Management><Pharmacy facility><Physicians><Pilot Projects><Policies><Preventative intervention><Protocol><Protocols documentation><Public Health><Qualitative Research><Randomized, Controlled Trials><Recurrence><Recurrent><Rehabilitation><Rehabilitation therapy><Research><Research Personnel><Research Resources><Researchers><Resources><Safety><Scientist><Specialist><Technology><Testing><Training><Work><acute care><advanced age><applewatch><care as usual><care coordination><career><cognitive dysfunction><cognitive loss><collaborative approach><coordinating care><data interpretation><digital health><disability><drug/agent><epidemiologic><epidemiological><fall risk><falls><field based data><field learning><field study><field test><geriatric><health care policy><healthcare policy><high risk><homes><injuries><intervention for prevention><interventional strategy><medication therapy management><mortality><multidisciplinary><older adult><older adulthood><physical therapist><physiotherapist><pilot study><prevent><preventing><preventing falls><prevention intervention><preventional intervention strategy><preventive intervention><programs><randomized control trial><rehab therapy><rehabilitative><rehabilitative therapy><senior citizen><services research><treatment as usual><usability><usual care>
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Donald Leslie Chi

UNIVERSITY OF WASHINGTON, SEATTLE, WA

Exploratory lead · 0/100
$155,500
FY 2025

Project Title

Microbiome Analysis of Plaque Samples from a Community-Based Socio-behavioral RCT to Reduce Sugared Fruit Drinks in Alaska Native Children

Grant Number:

5R03DE033779-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/15/2024

End Date:

4/14/2026

Project Abstract

Project Summary/Abstract Dental caries is one of the most significant public health challenges in Alaska Native communities. Added sugars from fruit drinks, especially Kool-Aid, are the main behavioral risk factor for caries. Our team developed and implemented a community-based intervention targetin...

Research Terms

<0-11 years old><Address><Affect><Age><Alaska Indian><Alaska Native><Alaskan American><Alaskan Indian><Alaskan Native><Alaskan Native American><Archives><Behavior><Behavior Conditioning Therapy><Behavior Modification><Behavior Therapy><Behavior Treatment><Behavioral><Behavioral Conditioning Therapy><Behavioral Modification><Behavioral Therapy><Behavioral Treatment><Behavioral trial><Biological Markers><Carbon Isotopes><Caries><Child><Child Youth><Children (0-21)><Clinical Research><Clinical Study><Communities><Community Health Aides><Conditioning Therapy><Control Groups><Data><Dental Decay><Dental caries><Disease Outcome><Educational process of instructing><Enrollment><Family><Fruit><Funding><Future><General Taxonomy><Goals><Grant><Hair><Health Inequity><Health Instruction><Health Status><Health Tutoring><Health education><Individuals from minority><Individuals of minority><Inequalities in Health><Inequities in Health><Intake><Intervention><Intervention Strategies><Knowledge><Level of Health><Link><Measures><Mediator><Minority Groups><Minority People><Minority Population><Minority individual><Mouth microbiome><NIDCR><NIDR><National Institute of Dental Research><National Institute of Dental and Craniofacial Research><Nitrogen Isotopes><Oral health><Outcome><Outcome Study><Parents><Policies><Process><Public Health><Ribosomal RNA><Risk Factors><Sampling><Self Efficacy><Social Behavior><Surrogate Markers><Taxonomy><Teaching><Techniques><Testing><Training><Tribes><Vulnerable Populations><Work><ages><analyze microbiome><behavior intervention><behavioral intervention><beta diversity><bio-markers><biologic marker><biomarker><community health worker><community intervention><community level intervention><community-based intervention><dental health><dietary fruit><enroll><group intervention><health inequalities><health level><indigenous community><insight><intervention effect><kids><microbiome><microbiome analysis><oral microbiome><parent><preservation><prevent><preventing><primary outcome><rRNA><recruit><secondary outcome><sociobehavior><sociobehavioral><sugar><surrogate bio-markers><surrogate biomarkers><tooth decay><vulnerable group><vulnerable individual><vulnerable people><youngster>
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Eric J Allenspach

SEATTLE CHILDREN'S HOSPITAL, SEATTLE, WA

Exploratory lead · 0/100
$141,768
FY 2024

Project Title

The role of SH2B3 in regulating CD8 T cells in Type 1 Diabetes

Grant Number:

5R03DK134746-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/1/2023

End Date:

1/31/2025

Project Abstract

PROJECT SUMMARY/ABSTRACT This project is a small grant program R03 application for Dr. Eric Allenspach, an Assistant Professor in the Department of Pediatrics at the University of Washington (UW). He is a recipient of an NIH Mentored Clinical Scientist Research Career Development Award (K08) from th...

Research Terms

<Acceleration><Adaptor Protein><Adaptor Protein Gene><Adaptor Signaling Protein><Adaptor Signaling Protein Gene><Adoptive Transfer><Affect><Affinity><Allele Frequency><Alleles><Allelomorphs><Animal Model><Animal Models and Related Studies><Animals><Antibodies><Antigen Presentation><Antigen Receptors><Antigens><Area><Autoantigens><Autoimmune><Autoimmune Diabetes><Autoimmune Diseases><Autoimmune Status><Autoimmunity><Autologous Antigens><Automobile Driving><B blood cells><B cell><B cells><B-Cells><B-Lymphocytes><B-cell><Basal Transcription Factor><Basal transcription factor genes><Biological><Blood monocyte><Body Tissues><Brittle Diabetes Mellitus><CD152><CD152 Antigen><CD152 Gene><CD25><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CTLA 4><CTLA-4 Gene><CTLA4><CTLA4 gene><CTLA4-TM><Career Development Awards><Career Development Awards and Programs><Career Development Programs K-Series><Cell Body><Cell Communication and Signaling><Cell Count><Cell Differentiation><Cell Differentiation process><Cell Number><Cell Signaling><Cell Survival><Cell Viability><Cell-Mediated Lympholytic Cells><Cells><Cellular biology><Characteristics><Childhood><Clinical><Co-Stimulator><Co-culture><Cocultivation><Coculture><Coculture Techniques><Code><Coding System><Common Cytokine Receptor Gamma Chain><Common Cytokine Receptor γ Chain><Common Gamma Chain><Common γ Chain><Complex><Costimulator><Coupled><Cues><Cytokine Receptors><Cytokine Signal Transduction><Cytokine Signaling><Cytolytic T-Cell><Cytotoxic T Cell><Cytotoxic T-Lymphocyte Protein 4><Cytotoxic T-Lymphocyte-Associated Antigen 4><Cytotoxic T-Lymphocyte-Associated Protein 4><Cytotoxic T-Lymphocyte-Associated Serine Esterase-4><Cytotoxic T-Lymphocytes><Data><Dendritic Cells><Development><Diabetes Mellitus><Disease><Disease Progression><Disorder><Effector Cell><Environmental Factor><Environmental Risk Factor><Epidermal Thymocyte Activating Factor><European><Flow Cytofluorometries><Flow Cytofluorometry><Flow Cytometry><Flow Microfluorimetry><Flow Microfluorometry><Funding><Future><Gamma Chain Interleukin 2 Receptor><Gene Frequency><Gene Transcription><General Transcription Factor Gene><General Transcription Factors><Genes><Genetic><Genetic Alteration><Genetic Change><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Risk><Genetic Susceptibility><Genetic Transcription><Genetic defect><Genetic propensity><Genetic study><Genotype><Goals><Grant><High Affinity Interleukin-2 Receptor><Hour><Human><IDDM><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><IL-15><IL-2><IL-2 Receptors><IL-7><IL-7 Gene><IL15><IL15 Protein><IL2 Protein><IL2 Receptors><IL21><IL2R><IL2RA><IL2RA gene><IL7><IL7 Protein><IL7 gene><Immune><Immune Interferon><Immune system><Immunes><Immunoblotting><Immunologic Subtyping><Immunology><Immunophenotyping><In Vitro><Incidence><Inherited Predisposition><Inherited Susceptibility><Insulin-Dependent Diabetes Mellitus><Interferon Gamma><Interferon Type II><Interleukin 2><Interleukin 2 Precursor><Interleukin 2 Receptor><Interleukin 2 Receptor Gamma><Interleukin 7 Precursor><Interleukin 7 Precursor Gene><Interleukin II><Interleukin-15><Interleukin-15 Precursor><Interleukin-2><Interleukin-7><Interleukin-7 Gene><Interleukine 2><Interleukine 2 Precursor><Interleukine II><Intracellular Communication and Signaling><Juvenile-Onset Diabetes Mellitus><K-Awards><K-Series Research Career Programs><Ketosis-Prone Diabetes Mellitus><LYP gene><LYP protein><Link><Lymphocyte Mitogenic Factor><Lymphoid Phosphatase><Lymphopoiesis><Lymphopoietin-1><MGC9721><MHC Receptor><Major Histocompatibility Complex Receptor><Marrow monocyte><Measures><Memory><Mentors><Mentorship><Mice><Mice Mammals><Mitogenic Factor><Modeling><Modern Man><Molecular><Monitor><Murine><Mus><Mutation><Myelogenous><Myeloid><Myelopoiesis><NIDDK><NIH><National Institute of Diabetes and Digestive and Kidney Diseases><National Institutes of Health><Non-Receptor Type 22 Protein Tyrosine Phosphatase><Non-Receptor Type 8 Protein Tyrosine Phosphatase><PEP gene><PEP protein><PTPN22><PTPN22 gene><PTPN8><Pancreas><Pancreatic><Pancreatic beta Cell><Pancreatic β-Cell><Pathogenicity><Pathway interactions><Peptides><Peripheral><Pest-Domain Phosphatase><Phenotype><Physicians><Predisposition gene><Principal Investigator><Progenitor Cells><Proliferating><Proteins><Publications><RNA Expression><Receptor Protein><Receptor Signaling><Refractory><Reporter><Reporting><Research><Research Career Program><Rheumatology><Risk><Risk-associated variant><Role><Sampling><Scientific Publication><Scientist><Self-Antigens><Shapes><Signal Transduction><Signal Transduction Systems><Signaling><Structure of beta Cell of islet><Sudden-Onset Diabetes Mellitus><Surface><Susceptibility Gene><T cell growth factor><T cell response><T-Cell Activation><T-Cell Antigen Receptors><T-Cell Development><T-Cell Growth Factor><T-Cell Growth Factor Receptors><T-Cell Ontogeny><T-Cell Receptor><T-Cell Stimulating Factor><T-Cells><T-Lymphocyte><T-Lymphocyte Development><T1 DM><T1 diabetes><T1D><T1DM><T8 Cells><T8 Lymphocytes><TCGF Receptors><TCGFR><Testing><Thymocyte Stimulating Factor><Tissues><Transcription><Transcription Factor Proto-Oncogene><Transcription factor genes><Transgenic Model><Type 1 Diabetes Mellitus><Type 1 diabetes><Type I Diabetes Mellitus><United States National Institutes of Health><Universities><Variant><Variation><Veiled Cells><Washington><Western Blotting><Western Immunoblotting><Work><activate T cells><adapter protein><allelic frequency><autoimmune condition><autoimmune disorder><autoimmunity disease><autoreactive T cell><biologic><biological signal transduction><career><career development><cell biology><cell type><cellular differentiation><cellular targeting><compare to control><comparison control><cytokine><cytotoxic T-lymphocyte antigen 4><developmental><diabetes><diabetes risk><disease risk><disorder risk><driving><environmental risk><exhaust><exhaustion><experience><flow cytophotometry><gene signatures><genetic association><genetic etiology><genetic mechanism of disease><genetic signature><genetic vulnerability><genetically predisposed><genome mutation><immunogen><immunophenotype><in vitro testing><in vivo><insulin dependent diabetes><insulin dependent type 1><insulitis><interest><interleukin-21><islet><islet autoimmunity><juvenile diabetes><juvenile diabetes mellitus><ketosis prone diabetes><killer T cell><lFN-Gamma><lymphocytopoiesis><model of animal><monocyte><mouse model><murine model><pancreas beta cell><pancreas β cell><pancreatic b-cell><pathway><pediatric><pediatric department><peptide immunization><peptide vaccination><predisposing gene><professor><programs><protein blotting><rare allele><rare mutation><rare variant><receptor><response><risk allele><risk gene><risk genotype><risk loci><risk locus><risk variant><self-reactive T cell><social role><stem cells><susceptibility allele><susceptibility locus><susceptibility variant><thymocyte><thymus derived lymphocyte><transcription factor><transgenic trait><translation strategy><translational approach><translational strategy><type I diabetes><type one diabetes>
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Jason Philip Van Batavia

CHILDREN'S HOSP OF PHILADELPHIA, PHILADELPHIA, PA

Exploratory lead · 0/100
$133,500
FY 2025

Project Title

Bladder Voiding After Stress Defeat Stress: Impact of Sex and Gonadal Hormones

Grant Number:

5R03DK139286-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

5/1/2024

End Date:

4/30/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT Lower urinary tract symptoms (LUTS) and disorders of voiding are among the most common reasons for referral to the urologist and affect ~20% of school-aged children. LUTS can be caused by one of several different LUT conditions, including voiding postponement, and the preval...

Research Terms

<0-11 years old><21+ years old><ACTH-Releasing Factor><Abscission><Adult><Adult Human><Affect><Age><Animal Model><Animal Models and Related Studies><Anxiety><Basic Research><Basic Science><Behavioral Assay><Birth><Bladder><Bladder Urinary System><Bladder outlet obstruction><Brain><Brain Nervous System><Brain Stem><Brain region><Brainstem><CRF Receptors><CRF receptor type 1><CRF-41><CRF-R1><CRF1 receptor><CRH Receptors><CRH-1><Causality><Cell Nucleus><Child><Child Youth><Children (0-21)><Chronic><Clinical><Clinical Sciences><Collaborations><Communication><Corticoliberin><Corticosterone><Corticotropin Releasing-Factor Receptors><Corticotropin-Releasing Factor><Corticotropin-Releasing Factor-41><Corticotropin-Releasing Hormone><Corticotropin-Releasing Hormone Receptors><Corticotropin-Releasing Hormone-41><Crh1 receptor><Data><Development><Diagnosis><Differences between sexes><Differs between sexes><Disease><Disorder><Dysfunction><Encephalon><Endocrine Gland Secretion><Ensure><Estrogen Receptors><Etiology><Excision><Exposure to><Extirpation><FISH Technic><FISH Technique><FISH analysis><FISH assay><Feeling><Female><Fluorescence In Situ Hybridization><Fluorescent in Situ Hybridization><Functional disorder><Future><Generalized Growth><Gonadal Hormones><Gonadal Steroid Hormones><Grant><Growth><HPA axis><Histology><Hormones><Knowledge><Laboratories><Link><Lower urinary tract><Measures><Mental Depression><Mental disorders><Mental health disorders><Mentors><Mice><Mice Mammals><Modeling><Murine><Mus><Muscle><Muscle Tissue><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Nerve Cells><Nerve Unit><Neural Cell><Neurocyte><Neurohormones><Neurons><Neuropeptides><Non-Polyadenylated RNA><Nucleus><Outcome><Overactive Bladder><Parturition><Pattern><Phenotype><Physiopathology><Population><Predisposition><Prevalence><Prevention><Psychiatric Disease><Psychiatric Disorder><Psychologic Stress><Psychological Stress><Psychosocial Factor><Psychosocial Stress><Publishing><QOL><Quality of life><RNA><RNA Gene Products><Receptor Protein><Removal><Research><Ribonucleic Acid><Rodent><Rodentia><Rodents Mammals><Role><School-Age Population><Schools><Sex Differences><Sex Hormones><Sex Steroid Hormones><Sexual differences><Stress><Surgical Removal><Susceptibility><Symptoms><Testing><Therapeutic Hormone><Tissue Growth><Urination><Urologist><Urology><Work><adult youth><adulthood><ages><alleviate symptom><ameliorating symptom><bully><bullying><causation><co-morbid><co-morbidity><comorbidity><corticotropin releasing hormone><corticotropin-releasing factor receptor 1><decrease symptom><depression><desensitization><developmental><disease causation><feelings><fewer symptoms><gonadal steroids><hormonal signals><hormone signals><hypothalamic-pituitary-adrenal (HPA) axis><hypothalamic-pituitary-adrenal axis><hypothalmus-pituitary-adrenal axis><improved><kids><lower urinary tract symptoms><male><mental illness><micturition><model of animal><muscular><neuronal><neuropsychiatric><neuropsychiatry><novel><ontogeny><optogenetics><pathophysiology><personalization of treatment><personalized medicine><personalized therapy><personalized treatment><psychiatric illness><psychological disorder><psychosocial stresses><psychosocial stressors><psychosocial variables><receptor><receptor expression><reduce symptoms><relieves symptoms><resection><resilience><resilient><response><school age><sex><sex based differences><sex dimorphism><sex related variation><sex steroid><sex variable><sex variation><sex-dependent differences><sex-related differences><sex-related variable><sex-specific differences><sexual dimorphism><sexually dimorphic><skills><social defeat><social role><social stress><socially stressed><stem><symptom alleviation><symptom reduction><symptom relief><urinary bladder><varies by sex><young adult><young adult age><young adulthood><youngster><♀><♂>
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Stephanie Lovinsky-Desir

COLUMBIA UNIVERSITY HEALTH SCIENCES, NEW YORK, NY

Exploratory lead · 0/100
$123,375
FY 2025

Project Title

Pollution and Lung Health in Active Youth (PLAY) at School

Grant Number:

5R03HL171440-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/15/2024

End Date:

2/28/2026

Project Abstract

PROJECT SUMMARY/ABSTRACT Over 3 million children in the United States attend schools within 100 meters of a major roadway, resulting in significant exposure to traffic-related air pollutants during school hours and while commuting to and from school. In our prior work, we have identified commuting ...

Research Terms

<0-11 years old><21+ years old><Address><Adult><Adult Human><Affect><Air><Air Pollutants><Air Pollution><Applications Grants><Asthma><Breathing><Bronchial Asthma><Calibration><Carbon Black><Cardiac Chronotropism><Cardiopulmonary><Child><Child Youth><Childhood><Children (0-21)><Communities><Commuting><Data><Development><Environment><Environmental Science><Exercise Test><Exposure to><Future><Global Positioning System><Grant Proposals><Green space><Health><Health Policy><Heart Rate><Height><High School Student><Hour><Individual><Inhalation><Inhalation Exposure><Inhaling><Intervention><Intervention Studies><Knowledge><Laboratories><Legislation><Link><Location><Lung><Lung Respiratory System><Maintenance><Measurement><Measures><Monitor><NHLBI><National Heart, Lung, and Blood Institute><Pattern><Physical activity><Physiology><Pilot Projects><Plants><Play><Policies><Pollution><Predisposition><Protocol><Protocols documentation><Public Health><Public Policy><Respiratory Aspiration><Respiratory Inspiration><Rest><Risk><Route><Schools><Secondary School Student><Secondary Student><Soot><Source><Statutes and Laws><Students><Subway><Susceptibility><Tidal Volume><Time><Transportation><Trees><United States><Urban Community><Walking><Washington><Work><Youth><Youth 10-21><adulthood><airway epithelium inflammation><airway inflammation><body sensor><body worn sensor><cohort><community intervention><community level intervention><community partnership><community-based intervention><cost efficient><data integration><developmental><environmental justice><evidence base><greenspace><health care policy><heart rate monitor><high schoolers><improved><innovate><innovation><innovative><inspiration><intervention research><interventional research><interventional study><interventions research><kids><life style intervention><lifestyle intervention><lung function><lung health><meter><multidisciplinary><novel><particulate pollutant><pediatric><pilot study><pollutant><programs><pulmonary><pulmonary function><pulmonary health><recruit><respiratory><respiratory airway volume><respiratory inflammation><respiratory tract inflammation><sensor><tech development><technology development><urban school><ventilation><wearable><wearable biosensor><wearable device><wearable electronics><wearable sensor><wearable sensor technology><wearable system><wearable technology><wearable tool><wearables><youngster><youth age>
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Gary Weissman

UNIVERSITY OF PENNSYLVANIA, PHILADELPHIA, PA

Exploratory lead · 0/100
$121,875
FY 2025

Project Title

Building equitable and feasible clinical decision support tools for population health management of people living with chronic lung disease

Grant Number:

5R03HL171424-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/15/2023

End Date:

11/30/2025

Project Abstract

PROJECT SUMMARY People living with chronic obstructive lung disease, interstitial lung disease, and other forms of chronic lung disease frequently experience exacerbations requiring acute care hospitalizations. These severe exacerba- tions requiring hospitalization are associated with decreased qual...

Research Terms

<21+ years old><AI based><Acute><Admission><Admission activity><Adult><Adult Human><Age><Algorithms><COPD><Calibration><Care Givers><Caregivers><Caring><Chronic Obstruction Pulmonary Disease><Chronic Obstructive Lung Disease><Chronic Obstructive Pulmonary Disease><Chronic lung disease><Clinical><Clinical Data><Clinical Decision Support Systems><Clinical Trials><Communities><Community Health Care><Data><Data Science><Data Set><Data Sources><Development><Diagnosis><Electronic Health Record><Electronics><Equity><Ethics><Feedback><Funding><Future><Gender><Health system><Hospital Admission><Hospitalization><Inequity><Interstitial Lung Diseases><Intervention><Interview><Investigators><K23 Award><K23 Mechanism><K23 Program><Knowledge><Laboratories><Lead><Life><Light><Link><Measures><Mental Depression><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Mentors><Methods><Mission><Modeling><Morbidity><Morbidity - disease rate><Out-patients><Outpatients><Output><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Pb element><Performance><Persons><Photoradiation><Pilot Projects><Population><Position><Positioning Attribute><Probability><Process><Process Measure><Protocol><Protocols documentation><QOL><Quality of life><Race><Races><Randomization trial><Reporting><Research Personnel><Research Resources><Researchers><Resources><Risk><Risk Factors><Science><Secure><Source><Structure><Subgroup><Survey Instrument><Surveys><Technology><Testing><Text><Time><Translating><United States><Update><Visual><Work><acceptability and feasibility><acute care><adulthood><ages><artificial intelligence based><barrier to care><barrier to health care><barrier to treatment><candidate identification><care delivery><career development><chronic obstructive pulmonary disorder><chronic pulmonary disease><clinical care><clinical decision support><clinical encounter><clinical predictive model><clinical predictors><clinically actionable><community care><computer based prediction><cost><dashboard><data pipeline><demographics><depression><developmental><disparity in care><disparity in health care><electronic><electronic device><electronic health care record><electronic health medical record><electronic health plan record><electronic health registry><electronic medical health record><ethical><experience><frailty><health care disparity><health care inequality><health care inequity><health care management><health management><heavy metal Pb><heavy metal lead><hospital re-admission><hospital readmission><improved><indexing><innovate><innovation><innovative><lab experience><lab training><laboratory experience><laboratory training><machine learning based model><machine learning model><mortality><obstacle to care><obstacle to health care><patient oriented outcomes><pilot study><population health><predictive modeling><predictive tools><racial><racial background><racial origin><randomized trial><randomized, clinical trials><re-admission><re-hospitalization><readmission><rehospitalization><response><secondary analysis><structured data><support tools><tool><treatment adherence><treatment compliance><unstructured data>
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Shylaja Srinivasan

UNIVERSITY OF CALIFORNIA, SAN FRANCISCO, SAN FRANCISCO, CA

Exploratory lead · 0/100
$121,125
FY 2025

Project Title

Pathophysiological sub-typing of pediatric type 2 diabetes based on clinical and genetic clustering methods

Grant Number:

5R03DK138213-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/1/2024

End Date:

12/31/2025

Project Abstract

PROJECT SUMMARY/ABSTRACT The incidence of type 2 diabetes (T2D) is rapidly increasing in youth, particularly in youth of color, and if uncontrolled can lead to devastating complications as early as 10 years after diagnosis. Yet, there are limited medication options for youth, who have worse response...

Research Terms

<12-20 years old><21+ years old><Address><Adolescence><Adolescent><Adolescent Youth><Adult><Adult Human><Adult-Onset Diabetes Mellitus><Adverse effects><Affect><Age><Algorithms><Aminotransferases><Automobile Driving><BMI><BMI percentile><BMI z-score><Biological><Biology><Body mass index><Boston><Categories><Childhood><Children's Hospital><Classification><Clinical><Clinical Data><Computerized Medical Record><Data><Data Set><Development><Diagnosis><Dimethylbiguanidine><Dimethylguanylguanidine><Disease><Disease Progression><Disorder><Dose><Drugs><Dysfunction><Electronic Medical Record><Ethnic Origin><Ethnicity><Eye><Eyeball><Fats><Fatty acid glycerol esters><Functional disorder><Funding><Future><Genetic><Genetic Determinism><Genomics><Genotype><Glycohemoglobin A><Glycosylated hemoglobin A><Goals><Hb A1><Hb A1a+b><Hb A1c><HbA1><HbA1c><Health><Hemoglobin A(1)><Heterogeneity><Incidence><Individual><Insulin deficiency><K23 Award><K23 Mechanism><K23 Program><Ketosis-Resistant Diabetes Mellitus><Kidney><Kidney Urinary System><Link><Lipids><Liver><Machine Learning><Maturity-Onset Diabetes Mellitus><Measures><Medication><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Metformin><Methods><Microvascular Dysfunction><Modeling><N,N-dimethyl-imidodicarbonimidic diamide><NIDDM><Nerve><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><OGTT><Obesity><Onset of illness><Oral Glucose Tolerance Test><Outcome><Pathway interactions><Pattern><Pediatric Hospitals><Performance><Personalized medical approach><Pharmaceutical Preparations><Phenotype><Physiopathology><Population><Predicting Risk><Prediction of Response to Therapy><Principal Investigator><Quetelet index><Regimen><Research><Risk><SEARCH for Diabetes in Youth><Slow-Onset Diabetes Mellitus><Stable Diabetes Mellitus><Subgroup><Systematics><T2 DM><T2D><T2DM><Techniques><Testing><Therapeutic><Transaminases><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Variant><Variation><Work><Youth><Youth 10-21><adiposity><adolescence (12-20)><adult onset diabetes><adulthood><ages><biobank><biologic><biorepository><children of color><clinical development><clinical practice><clinical validation><computer based prediction><corpulence><customized therapy><customized treatment><developmental><disease onset><disorder onset><driving><drug/agent><early adulthood><effective therapy><effective treatment><emerging adult><forecasting risk><genetic determinant><genome scale><genome-wide><genomewide><genomic data><genomic dataset><hemoglobin A1c><hepatic body system><hepatic organ system><high risk><improved><individualized approach><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><insulin sensitivity><juvenile><juvenile human><ketosis resistant diabetes><machine based learning><machine learned algorithm><machine learning algorithm><machine learning based algorithm><maturity onset diabetes><microvascular complications><microvascular disease><novel><pathophysiology><pathway><patient specific therapies><patient specific treatment><pediatric><personalized approach><pharmacologic><polygenic predictors><polygenic scores><precision approach><precision medicine><precision-based medicine><predict risk><predict risks><predict therapeutic response><predict therapy response><predicted risk><predicted risks><predicting risks><predictive modeling><predictive risk><predicts risk><racial diversity><racially diverse><renal><response><response to therapy><response to treatment><risk prediction><risk predictions><risk stratification><small vessel disease><stratify risk><tailored approach><tailored medical treatment><tailored therapy><tailored treatment><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><therapeutic response><therapy prediction><therapy response><treatment prediction><treatment response><treatment response prediction><treatment responsiveness><treatment strategy><type 2 DM><type II DM><type two diabetes><unique treatment><unsupervised learning><unsupervised machine learning><youth age><youth of color>
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John W Evankovich

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 0/100
$118,070
FY 2025

Project Title

Fibronectin Extra Domain A Degradation as an Antifibrotic Approach in Lung Fibrosis

Grant Number:

5R03HL173071-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2026

Project Abstract

ABSTRACT This application is for an NHLBI R03 Small Grant Award for K08 Recipients entitled “Fibronectin Extra Domain A Degradation as an Antifibrotic Approach in Lung Fibrosis.” I am a physician in Pulmonary and Critical Care Medicine at the University of Pittsburgh, and I am building a research pr...

Research Terms

<APF-1><ATP-Dependent Proteolysis Factor 1><Allergy><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Assay><Attenuated><Automobile Driving><Award><Back><Binding><Bioassay><Biological Assay><Bleo><Bleomycin><Bone-Derived Transforming Growth Factor><CAR T cells><CAR modified T cells><CAR-T><CAR-Ts><Cell Body><Cell Communication and Signaling><Cell Signaling><Cell surface><Cell-Extracellular Matrix><Cells><Chronic><Clinical><Cold-Insoluble Globulins><Collagen><Critical Care><Data><Defect><Degradation Pathway><Degradative Pathway><Deposit><Deposition><Development><Diagnosis><Disease><Disorder><Dorsum><Drug Therapy><Drugs><ECM><Embryo><Embryo Development><Embryogenesis><Embryonic><Embryonic Development><Endosomes><Extracellular Matrix><Extracellular Matrix Degradation><Extracellular Matrix Proteins><FN1><FTI><Farnesyl Transferase Inhibitor><Farnesyltransferase Inhibitors><Fibroblasts><Fibronectin 1><Fibronectins><Fibrosing Alveolitis><Fibrosis><Glycoprotein GP-2><Glycoproteins><Grant><Growth Agents><Growth Factor><Growth Substances><HMG-20><Half-Life><High Mobility Protein 20><High Throughput Assay><Human><Immune><Immunes><Immunologic Receptors><Immunological Receptors><In Vitro><Inflammatory><Integrins><Integrins Extracellular Matrix><Interstitial Lung Diseases><Intracellular Communication and Signaling><Investigation><Isoforms><KO mice><Knock-out Mice><Knockout Mice><LETS Proteins><Laminin><Large External Transformation-Sensitive Protein><Learning><Ligands><Lonafarnib><Lung><Lung Diseases><Lung Respiratory System><Lung Tissue Fibrosis><Lysosomes><Medication><Medicine><Metabolic Protein Degradation><Methodology><Milk Growth Factor><Modeling><Modern Man><Molecular><Molecular Interaction><Morbidity><Morbidity - disease rate><Myofibroblast><NHLBI><National Heart, Lung, and Blood Institute><Null Mouse><O element><O2 element><Opsonic Glycoprotein><Opsonic alpha(2)SB Glycoprotein><Oxygen><Pathogenesis><Pathologic><Pathway interactions><Patients><Pattern><Pharmaceutical Preparations><Pharmacological Treatment><Pharmacotherapy><Physicians><Platelet Transforming Growth Factor><Pre-Clinical Model><Preclinical Models><Property><Protein Farnesyltransferase Inhibitors><Protein Isoforms><Protein Turnover><Proteins><Proteins Growth Factors><Publishing><Pulmonary Diseases><Pulmonary Disorder><Pulmonary Fibrosis><RNA Splicing><Receptor Protein><Receptosomes><Recycling><Regulatory Protein Degradation><Reporting><Research><Sarasar><Scaffolding Protein><Scientist><Severities><Signal Transduction><Signal Transduction Systems><Signaling><Site><Slice><Splicing><Supportive Therapy><Supportive care><System><Systemic Scleroderma><Systemic Sclerosis><T cells for CAR><TGF B><TGF-beta><TGF-β><TGFbeta><TGFβ><TLR protein><Testing><Time><Toll-Like Receptor Family Gene><Toll-like receptors><Training><Transforming Growth Factor beta><Transforming Growth Factor-Beta Family Gene><Ubiquitilation><Ubiquitin><Ubiquitination><Ubiquitinoylation><Universities><Variant><Variation><Work><alpha 2-Surface Binding Glycoprotein><attenuate><attenuates><biological signal transduction><burden of disease><burden of illness><cell type><chimeric antigen T cell receptor><chimeric antigen receptor (CAR) T cells><chimeric antigen receptor T><chimeric antigen receptor T cells><chimeric antigen receptor fusion protein T-cells><chimeric antigen receptor modified T cells><developmental><diffuse interstitial pulmonary fibrosis><disease burden><disease of the lung><disorder of the lung><driving><drug intervention><drug repositioning><drug repurposing><drug treatment><drug/agent><druggable target><effective therapy><effective treatment><fibrosis in the lung><fibrotic lung disease><fibrotic pulmonary disease><high throughput screening><idiopathic pulmonary fibrosis><immune receptor><in vivo><insight><interstitial><lung disorder><lung fibrosis><mortality><mouse model><murine model><new approaches><novel><novel approaches><novel strategies><novel strategy><pathway><patient subclass><patient subcluster><patient subgroups><patient subpopulations><patient subsets><patient subtypes><pharmaceutical intervention><pharmacological intervention><pharmacological therapy><pharmacology intervention><pharmacology treatment><pharmacotherapeutics><polypeptide><prevent><preventing><programs><progressive systemic sclerosis><protein degradation><pulmonary><receptor><repurposing agent><repurposing medication><response><trafficking><ubiquination><ubiquitin conjugation>
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Xingxing Shelley Cheng

STANFORD UNIVERSITY, STANFORD, CA

Exploratory lead · 0/100
$112,871
FY 2024

Project Title

The Role of Pretransplant Services on Outcomes and Costs in Kidney Transplantation

Grant Number:

5R03DK134795-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/28/2025

Project Abstract

Project Summary / Abstract This R03 proposal is a supplement to the K23 proposal of Dr. Xingxing S. Cheng, MD MS. The purpose of Dr. Cheng’s K23 is to refine the process of screening of coronary artery disease in patients with chronic kidney disease on the waitlist for kidney transplantation. The pu...

Research Terms

<Affect><Caring><Case Mixes><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinical Investigator><Communities><Coronary Arteriosclerosis><Coronary Artery Disease><Coronary Artery Disorder><Coronary Atherosclerosis><Cost Analyses><Cost Analysis><Cost Savings><Data><Data Bases><Databases><Diagnostic tests><Dialysis><Dialysis procedure><ESRD><End stage renal failure><End-Stage Kidney Disease><End-Stage Renal Disease><Environment><Evaluation><Expenditure><Fee-for-Service Plans><Fees for Service><Grant><Health><Health Insurance for Aged and Disabled, Title 18><Health Insurance for Disabled Title 18><Healthcare><Hospital Admission><Hospital Costs><Hospitalization><Hospitalization cost><Insurance Carriers><Insurance Coverage><Insurance Status><Insurers><Ischemic Heart><Ischemic Heart Disease><Ischemic myocardium><K23 Award><K23 Mechanism><K23 Program><Kidney><Kidney Grafting><Kidney Transplantation><Kidney Transplants><Kidney Urinary System><Laboratories><Link><Living Donors><Maintenance><Medical Surveillance><Medicare><Mentored Patient-Oriented Research Career Development Award><Mentored Patient-Oriented Research Career Development Award (K23)><Methodology><Minority><Minority Status><Myocardial Ischemia><Nephrectomy><Organ><Outcome><Patients><Persons><Policies><Population><Practice Guidelines><Price><Privatization><Procedures><Process><Provider><QOC><Quality of Care><Renal Grafting><Renal Transplantation><Renal Transplants><Reporting><Research><Rest><Role><Salaries><Services><Time><Title 18><Training><Transplant Recipients><Transplantation><United States><Wages><Waiting Lists><assess cost><atherosclerotic coronary disease><cardiac ischemia><care coordination><care costs><chronic kidney disease><co-morbid><co-morbidity><comorbidity><coordinating care><coronary arterial disease><coronary ischemia><cost><cost assessment><cost estimate><cost estimation><cost evaluation><crosslink><data base><dialysis therapy><econometrics><ethnic minority><evaluate cost><examine cost><health care><health insurance for disabled><heart ischemia><improved><indexing><kidney tx><live kidney donor><living kidney donor><mortality><myocardial ischemia/hypoxia><myocardium ischemia><payment><pricing><programs><racial minority group><racial minority individual><racial minority people><racial minority population><renal><screening><screenings><sex><social role><transplant><transplant patient><transplant registry><waitlist>
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Cary Ragan Boyd-Shiwarski

UNIVERSITY OF PITTSBURGH AT PITTSBURGH, PITTSBURGH, PA

Exploratory lead · 0/100
$104,936
FY 2025

Project Title

Establishing new model systems to study low potassium induced kidney injury

Grant Number:

5R03DK138215-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/25/2024

End Date:

12/31/2025

Project Abstract

ABSTRACT BOYD-SHIWARSKI The purpose of this R03 proposal is to develop pilot studies using new research methodology and technology to investigate how dietary potassium (K+) deficiency leads to kidney injury. It is well known that dietary K+ deficiency leads to hypertension, cardiovascular disease, a...

Research Terms

<3-D><3-D modeling><3-D structure><3-Dimensional><3-dimensional structure><3D><3D modeling><3D structure><Acceleration><Agriculture><Alternative Complement Pathway><American><Apical><Biologic Models><Biological Models><Cardiovascular Diseases><Cell Body><Cell Culture Techniques><Cell Line><Cell Survival><Cell Viability><Cell model><Cell-Extracellular Matrix><CellLine><Cells><Cellular model><Chronic><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Collagen><Complement Activation><Consumption><Culturing, in vitro Vertebrate, Primary><Development><Didelphidae><Diet><Dietary K><Dietary Potassium><Distal Convoluted Tubule><Distal Kidney Tubules><Distal convoluted renal tubule structure><ECM><ELISA><Electron Microscopy><Endocrine><Environment><Enzyme-Linked Immunosorbent Assay><Epithelial Cells><Extracellular Matrix><Fibrosis><Food><Foundations><Funding><Genes><Glomerular Filtration Rate><Goals><Grant><Health><Human><Hypertension><Hypokalemia><Hypopotassemia><Immune><Immune Cell Activation><Immune response><Immunes><Immunoblotting><Immunofluorescence><Immunofluorescence Immunologic><Immunologic Stimulation><Immunological Stimulation><Immunostimulation><In Vitro><Inflammation><Injury to Kidney><Intake><K element><Kidney><Kidney Diseases><Kidney Tubules><Kidney Urinary System><Link><Measures><Mediating><Methodology><Mice><Mice Mammals><Microfluidics><Model System><Modeling><Modern Man><Morphogenesis><Murine><Mus><NIDDK><National Institute of Diabetes and Digestive and Kidney Diseases><Nephropathy><Nutrient><Opossums><Pathologic><Patients><Perfusion><Permeability><Physiology><Pilot Projects><Play><Population><Potassium><Potassium Deficiency><Predisposition><Primary Cell Cultures><Process><Properdin Pathway><Proteins><Proximal Kidney Tubules><Publications><RNA Seq><RNA sequencing><RNAseq><Renal Disease><Renal tubule structure><Research><Research Methodology><Research Methods><Role><Scientific Publication><Soil><Strains Cell Lines><Stress><Structure><Surface><Susceptibility><System><Technology><Testing><Tubular><Tubular formation><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Western Blotting><Western Immunoblotting><access restrictions><bio-printing><bioprinting><cardiovascular disorder><cell culture><cell cultures><chronic kidney disease><complement pathway regulation><cultured cell line><cytokine><design><designing><developmental><diets><enzyme linked immunoassay><extracellular><fluid flow><fruits and vegetables><global gene expression><global transcription profile><high blood pressure><host response><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><immune activation><immune system response><immunoresponse><inflammation marker><inflammatory marker><innovate><innovation><innovative><kidney disorder><kidney injury><mechanical force><monolayer><morphogenetic process><pilot study><pressure><protein blotting><renal><renal disorder><renal injury><renal proximal tubule><renal tubule><research and methods><response><salt hypertension><salt induced hypertension><salt sensitive hypertension><scaffold><scaffolding><shear stress><social role><three dimensional><three dimensional structure><three-dimensional modeling><transcriptome><transcriptome sequencing><transcriptomic sequencing><western diet><western-style diet><western-type diet><µfluidic>
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Daniel Harrison Craighead

UNIVERSITY OF MINNESOTA, MINNEAPOLIS, MN

Exploratory lead · 0/100
$95,773
FY 2025

Project Title

Smartphone app-guided inspiratory muscle strength training for lowering systolic blood pressure

Grant Number:

7R03HL171108-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

1/10/2024

End Date:

12/31/2025

Project Abstract

PROJECT SUMMARY High blood pressure (BP), particularly systolic BP (SBP), is the major modifiable risk factor for cardiovascular diseases (CVD) and related conditions such as chronic kidney disease and cognitive decline/dementia. In fact, ~60% of adults in the United States have above-normal SBP (≥1...

Research Terms

<21+ years old><Active Follow-up><Adherence><Adopted><Adult><Adult Human><Adverse Experience><Adverse event><Aerobic Activity><Aerobic Exercise><Aerobic Training><Aerobic fitness><Age><Amentia><American Heart Association><Android App><Android Application><BP control><BP management><Biomedical Research><Blood Pressure><Blood Pressure Monitors><Cardiovascular Diseases><Cell Phone><Cell Phone Application><Cell phone App><Cellular Phone><Cellular Phone App><Cellular Phone Application><Cellular Telephone><Chronic Disease><Chronic Illness><Chronic Kidney Failure><Chronic Renal Disease><Chronic Renal Failure><Clinic><Clinical Research><Clinical Study><Clinical Trials><Cognitive Disturbance><Cognitive Impairment><Cognitive decline><Cognitive function abnormal><Communities><Consumption><Continuous Sphygmomanometers><Dementia><Devices><Disease><Disorder><Dissemination and Implementation><Disturbance in cognition><Double-Blind Method><Double-Blind Study><Double-Blinded><Double-Masked Method><Double-Masked Study><Dropout><Education for Intervention><Educational Intervention><Elements><Endothelium><Environment><Feedback><Funding><Future><Goals><Health><Health Care Technology><Health Technology><Healthy diet><Home><Hypertension><Impaired cognition><Inhalation><Inhaling><Innovative Therapy><Instruction Intervention><Intervention><Investigators><Measures><Mediating><Minor><Mobile Phones><Monitor><NHLBI><National Heart, Lung, and Blood Institute><Participant><Pilot Projects><Public Health><Randomized><Randomized, Controlled Trials><Research><Research Design><Research Personnel><Research Priority><Researchers><Resistance><Safety><Smart Phone App><Smart Phone Application><Smartphone App><Study Type><Supervision><Time><Training><Training Intervention><Training Programs><Translating><Translations><Travel><United States><Vascular Endothelium><Vascular Hypertensive Disease><Vascular Hypertensive Disorder><Woman><active followup><adulthood><ages><app based delivery><app delivery><app on a smartphone><app-delivered><application on a smartphone><balanced diet><blood pressure control><blood pressure management><brachial artery><cardiovascular disease risk><cardiovascular disorder><cardiovascular disorder risk><cardiovascular health><cardiovascular risk><cardiovascular risk factor><cell phone based app><chronic disorder><chronic kidney disease><clinical efficacy><clinical practice><cognitive dysfunction><cognitive loss><community setting><comparable efficacy><comparative efficacy><compare efficacy><cost><data collected in real world><design><designing><digital health><effective therapy><effective treatment><effectiveness testing><emerging epidemic><exercise program><fitness program><follow up><follow-up><followed up><followup><good diet><handheld device><handheld equipment><healthy lifestyle><high blood pressure><homes><hyperpiesia><hyperpiesis><hypertensive disease><hypertensive disorder><iOS app><iOS application><iPhone><iPhone App><iPhone Application><improved><innovate><innovation><innovative><insight><instructional intervention><instrument><life style intervention><lifestyle intervention><m-Health><mHealth><malleable risk><men><mobile application delivered><mobile application delivery><mobile health><mobile phone app><modifiable risk><muscle strength><muscle strengthening><new epidemic><novel><novel epidemic><phone app><phone application><pilot study><pilot test><portability><pressure><primary outcome><randomisation><randomization><randomized control trial><randomly assigned><real world data><remote monitoring><resistant><smart phone><smartphone><smartphone application><smartphone based app><smartphone based application><strength training><study design><translation><trial design><uptake><vascular endothelial dysfunction>
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Manoj M. Pillai

YALE UNIVERSITY, NEW HAVEN, CT

Exploratory lead · 0/100
$83,750
FY 2024

Project Title

Biology of terminal R-loops in splicing factor mutant cancers

Grant Number:

5R03CA270656-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2023

End Date:

3/31/2025

Project Abstract

This resubmitted R03 application seeks to determine how recurrent mutations common in splicing factors (SF) lead to changes in chromatin accessibility and epigenetic landscape, thereby contributing to oncogenesis. Recurrent mutations in SF are prevalent across multiple unrelated cancer types includi...

Research Terms

<AML - Acute Myeloid Leukemia><ATAC sequencing><ATAC-seq><ATACseq><Acute Myeloblastic Leukemia><Acute Myelocytic Leukemia><Acute Myelogenous Leukemia><Adeno-Associated Viruses><Alternate Splicing><Alternative RNA Splicing><Alternative Splicing><Architecture><Assay><Assay for Transposase-Accessible Chromatin using sequencing><Automobile Driving><B-Cell CLL><B-Cell Chronic Lymphocytic Leukemia><B-Cell Chronic Lymphogenous Leukemia><B-Cell Chronic Lymphoid Leukemia><B-Cell Lymphocytic Leukemia><B-Lymphocytic Leukemia><Bioassay><Biochemical><Biochemical Process><Biochemistry><Biologic Models><Biological Assay><Biological Chemistry><Biological Models><Biology><Body Tissues><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancer Cause><Cancer Etiology><Cancer Genes><Cancer Treatment><Cancer-Promoting Gene><Cancers><Cas nuclease technology><Catalysis><Cell Body><Cell Line><CellLine><Cells><Chemistry><Chromatin><Chronic B-Lymphocytic Leukemia><Chronic Lymphatic Leukemia><Chronic Lymphoblastic Leukemia><Chronic Lymphocytic Leukemia><Chronic Lymphogenous Leukemia><Clonal Evolution><Closure by Ligation><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Cytoplasm><Cytosine><DNA><DNA replication fork><DNA-Dependent RNA Polymerase II><Data><Data Set><Defect><Deoxyribonucleic Acid><Dependoparvovirus><Dependovirus><Development><Disease><Disorder><Disparate><Engineering / Architecture><Epigenetic><Epigenetic Change><Epigenetic Mechanism><Epigenetic Process><Event><Exons><Family><Gene Expression><Gene Transcription><Generalized Growth><Genetic Alteration><Genetic Change><Genetic Transcription><Genetic defect><Genome Instability><Genomic Instability><Growth><HDAC><HDAC Proteins><HDAC2><HDAC2 gene><Histone Deacetylase><Image><Intraocular Melanoma><Investigation><Label><Lead><Ligation><Link><Location><Malignant Melanoma><Malignant Neoplasm Therapy><Malignant Neoplasm Treatment><Malignant Neoplasms><Malignant Tumor><Malignant Tumor of the Lung><Malignant neoplasm of lung><Mediating><Melanoma><Messenger RNA><Metabolic><Model System><Molecular><Mutate><Mutation><Nature><Non-Polyadenylated RNA><Oncogenes><Oncogenesis><Oncogenic><Pathogenicity><Pathologic><Pathway interactions><Patients><Pb element><Physiology><Play><Polymerase><Position><Positioning Attribute><Production><Proteins><Pulmonary Cancer><Pulmonary malignant Neoplasm><RNA><RNA Expression><RNA Gene Products><RNA Polymerase B><RNA Polymerase II><RNA Processing><RNA Seq><RNA Splicing><RNA library><RNA sequencing><RNAseq><Recurrence><Recurrent><Regulation><Resolution><Ribonucleic Acid><Role><S Period><S Phase Arrest><S phase><SC35><SRSF2><SRSF2 gene><Sampling><Serine/Arginine-Rich Splicing Factor 2><Site><Spliceosomes><Splicing><Strains Cell Lines><Structure><Synthesis Period><Synthesis Phase><Tissue Growth><Tissues><Transcript><Transcription><Transcription Regulation><Transcriptional Control><Transcriptional Regulation><Transforming Genes><Translations><Tumor Suppressor Proteins><Uracil><Uveal Melanoma><YAF1><acute granulocytic leukemia><acute myeloid leukemia><adeno associated virus group><anti-cancer therapy><assay for transposase accessible chromatin followed by sequencing><assay for transposase accessible chromatin seq><assay for transposase accessible chromatin sequencing><assay for transposase-accessible chromatin with sequencing><cancer therapy><cancer type><cancer-directed therapy><chronic lymphoid leukemia><cultured cell line><developmental><disease model><disorder model><driving><epigenetic regulation><epigenetically><genome integrity><genome mutation><genome scale><genome-wide><genomewide><genomic integrity><heavy metal Pb><heavy metal lead><imaging><in vivo Model><lung cancer><mRNA><mRNA Export><mRNA Stability><malignancy><mutant><neoplasm/cancer><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><non-synonymous mutation><nonsynonymous mutation><novel><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><nucleic acid structure><ontogeny><overexpress><overexpression><pathway><replication fork><resolutions><response><shRNA><short hairpin RNA><small hairpin RNA><small molecular inhibitor><small molecule inhibitor><social role><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><transcriptome sequencing><transcriptomic sequencing><translation><tumor><tumor suppressor><tumorigenesis><uvea melanoma>
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Jonathan S Reichner

RHODE ISLAND HOSPITAL, PROVIDENCE, RI

Exploratory lead · 0/100
$82,000
FY 2024

Project Title

Investigating the Ability of Human Blood Neutrophils to Kill Cancer

Grant Number:

5R03CA280714-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/5/2023

End Date:

3/31/2025

Project Abstract

Abstract Neutrophils are not often considered as cancer killing immune cells in the same way that natural killer cells, cytotoxic T cells and macrophages. However, the inherent capability of neutrophils to be cytotoxic is clinically evident in diseases of hyperinflammation (such as sepsis) where act...

Research Terms

<3-D><3-Dimensional><3D><3D cell culture><3D culture><Ab-dependent cellular cytotoxicity><Adherent Culture><Adhesions><Adjuvant><Adjuvant Chemotherapy><Adjuvant Drug Therapy><Agonist><Antibodies><Antibody Therapy><Antitumor Response><Apoptosis><Apoptosis Pathway><Beta 2 Integrin Chain><Biological Mimetics><Biomimetics><Blood Neutrophil><Blood Polymorphonuclear Neutrophil><Body Tissues><Breast Cancer><Breast Cancer Cell><Breast Cancer Patient><Breast Tumor Patient><Budgets><CD11a Beta Subunit><CD11b><CD11b Beta Subunit><CD11c Beta Subunit><CD18><CD18 Antigens><CR3><CR3 Receptor><CR3A><Cancers><Cell Body><Cell membrane><Cell surface><Cell-Extracellular Matrix><Cell-Mediated Lympholytic Cells><Cells><Cellular Spheroids><Cessation of life><Clinic><Clinical><Collaborations><Complement><Complement 3 Receptor><Complement Proteins><Cytolytic T-Cell><Cytoplasmic Membrane><Cytotoxic T Cell><Cytotoxic T-Lymphocytes><Cytotoxic cell><Data><Death><Disease><Disorder><ECM><EGF Receptor><EGFR><ERBB Protein><Effectiveness><Effector Cell><Elasticity><Epidermal Growth Factor Receptor><Epidermal Growth Factor Receptor Kinase><Epidermal Growth Factor Receptor Protein-Tyrosine Kinase><Epidermal Growth Factor-Urogastrone Receptors><Exhibits><Extracellular Matrix><Family><Fibroblasts><Fibroins><Gel><Genetic><Greek><HER1><Host Defense><Human><ITGAM><ITGAM gene><ITGB2><ITGB2 gene><Immune><Immune mediated therapy><Immune response><Immunes><Immunological response><Immunologically Directed Therapy><Immunotherapy><Infection><Integrin Beta-2><Integrin alpha-M beta-2><Integrin alphaMbeta2><Integrin beta2><Integrins><Integrins Extracellular Matrix><Invaded><K lymphocyte><LCAMB><Laboratories><Learning><Lectin><MAC1A><MDA MB 231><MDA-231><MDA-MB231><MF17><MO1A><Mac 1><Mac-1 Adhesive Receptor><Mac-1 Antigen><Mac-1 Receptor><Macrophage><Macrophage-1 Antigen><Malignant Breast Neoplasm><Malignant Cell><Malignant Neoplasms><Malignant Tumor><Marrow Neutrophil><Mediating><Medical><Mo1 Antigen Receptor><Mo1 Glycoprotein Receptor><Modeling><Modern Man><Monolayer culture><Multicellular Spheroids><Mφ><NK Cells><Natural Killer Cells><Necrosis><Necrotic><Neoplasm Antibodies><Neutrophil Infiltration><Neutrophil Recruitment><Neutrophilic Granulocyte><Neutrophilic Infiltrate><Neutrophilic Leukocyte><Organ><Organ failure><Phagocytosis><Physiologic><Physiological><Plasma Membrane><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Programmed Cell Death><Protocol><Protocols documentation><Psychological reinforcement><Publishing><Puncture procedure><Punctures><Receptor Protein><Regulatory Element><Reinforcement><Sepsis><Silk><Site><Structure><Synapses><Synaptic><System><TGF-alpha Receptor><TNBC><Testing><Therapeutic><Tissues><Transforming Growth Factor alpha Receptor><Tumor Antibodies><Tumor Cell><Urogastrone Receptor><Work><anti-cancer><anti-cancer immunotherapy><anti-tumor antibody><anti-tumor response><antibody based therapies><antibody dependent cell mediated cytotoxicity><antibody dependent cytotoxicity><antibody mediated cellular cytotoxicity><antibody treatment><antibody-based therapeutics><antibody-based treatment><antibody-dependent cell cytotoxicity><antibody-dependent cellular cytotoxicity><antibody-mediated cytotoxicity><anticancer immunotherapy><antitumor antibody><blood infection><bloodstream infection><breast tumor cell><c-erbB-1><c-erbB-1 Protein><cancer cell><cancer immunotherapy><cancer progression><cell killing><clinical relevance><clinically relevant><complementation><cytotoxic><determine efficacy><druggable target><efficacy analysis><efficacy assessment><efficacy determination><efficacy evaluation><efficacy examination><erbB-1><erbB-1 Proto-Oncogene Protein><erbBl><evaluate efficacy><examine efficacy><experiment><experimental research><experimental study><experiments><host response><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based cancer therapies><immune-based therapies><immune-based treatments><immuno therapy><immunoresponse><immunotherapy for cancer><immunotherapy of cancer><insight><interest><killer T cell><live cell image><live cell imaging><live cellular image><live cellular imaging><malignancy><malignant breast tumor><migration><neoplasm progression><neoplasm/cancer><neoplastic cell><neoplastic progression><neutrophil><physical property><plasmalemma><proto-oncogene protein c-erbB-1><receptor><spheroids><synapse><three dimensional><three dimensional cell culture><triple-negative breast cancer><triple-negative invasive breast carcinoma><tumor><tumor progression><αMβ2>
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Robert B Abramovitch

MICHIGAN STATE UNIVERSITY, EAST LANSING, MI

Exploratory lead · 0/100
$77,931
FY 2025

Project Title

Defining the antibacterial activities of ozonides

Grant Number:

5R03AI182633-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

2/22/2024

End Date:

12/31/2025

Project Abstract

New classes of antibacterials are required to combat the spread of antimicrobial resistance (AMR). AMR is an underlying factor in ~5 million deaths worldwide each year and deaths due to resistant microbes are predicted to overtake cancer by 2050. Despite this grave forecast, the pipeline of new anti...

Research Terms

<Aminoglycosides><Anti Mycobacterial Agents><Anti-Bacterial Agents><Anti-malarials><Antimicrobial Resistance><Antimycobacterial Agents><Bacteria><Bioavailability><Biological Availability><Cancers><Cell Body><Cells><Cessation of life><Clinical Trials><Collection><Data><Death><Development><Dose><Drug Kinetics><Drug or chemical Tissue Distribution><E coli><E faecalis><E. coli><E. faecalis><Enterococcus faecalis><Escherichia coli><Fe element><Fluoroquinolones><Future><Gene Expression Monitoring><Gene Expression Pattern Analysis><Gene Expression Profiling><Generalized Growth><Genes><Genus Mycobacterium><Goals><Growth><Half-Life><Human><In Vitro><Infection><Iron><M abscessus><M smegmatis><M tb><M tuberculosis><M. abscessus><M. smegmatis><M. tb><M. tuberculosis><Malignant Neoplasms><Malignant Tumor><Microbe><Modern Man><Mycobacterium><Mycobacterium abscessus><Mycobacterium smegmatis><Mycobacterium tuberculosis><Mycobacteroides abscessus><New Agents><Oral><Pathogenesis><Pathway interactions><Peroxides><Pharmacokinetics><Physiologic Availability><Predisposition><Property><Proteus vulgaris><Regulation><Resistance><S aureus><S faecalis><S. aureus><S. faecalis><Safety><Staph aureus><Staphylococcus aureus><Streptococcus Group D><Streptococcus faecalis><Structure-Activity Relationship><Susceptibility><TB therapy><TB treatment><Testing><Tissue Distribution><Tissue Growth><Transcript Expression Analyses><Transcript Expression Analysis><analog><analyze gene expression><anti-bacterial><anti-malarial agents><anti-malarial drugs><anti-microbial><anti-microbial resistant><antimicrobial><antimycobacterial><bacteria pathogen><bacterial pathogen><beta lactam antibiotic><beta-Lactams><chemical structure function><combat><developmental><gene expression analysis><gene expression assay><in vitro Model><malignancy><meter><mouse model><mtb><murine model><neoplasm/cancer><novel><ontogeny><pathogen><pathogenic bacteria><pathway><priority pathogen><resistance to anti-microbial><resistant><resistant to antimicrobial><structure function relationship><transcriptional profiling><treat M. tuberculosis><treat Mtb><treat Mycobacterium tuberculosis><treat tb><treat tuberculosis><tuberculosis therapy><tuberculosis treatment><β lactam antibiotic><β-Lactams>
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Alyssa Kate McGonagle

UNIVERSITY OF NORTH CAROLINA CHARLOTTE, CHARLOTTE, NC

Exploratory lead · 0/100
$77,000
FY 2024

Project Title

Work Design, Self-Management, and Work Ability in Workers with Diabetes

Grant Number:

5R03OH012449-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

ALLCDC

Start Date:

9/1/2023

End Date:

8/31/2025

Project Abstract

PROJECT SUMMARY Diabetes is a common chronic condition among U.S. adults, affecting an estimated 34.1 million adults; it also disproportionately affects those of lower socio-economic status. Diabetes management is complex, involving lifestyle changes (i.e., physical activity and dietary changes), we...

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Analiz Rodriguez

UNIV OF ARKANSAS FOR MED SCIS, LITTLE ROCK, AR

Exploratory lead · 0/100
$76,500
FY 2025

Project Title

Development of immunocompetent melanoma brain metastases organoids

Grant Number:

5R03CA289645-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/6/2024

End Date:

2/28/2026

Project Abstract

Abstract Immune checkpoint inhibition (ICI) can control intracranial disease in approximately 50% of patients with melanoma brain metastases (MBM), which is the leading cause of death for these cancer patients - implicating that immune microenvironment (IM) modulation can be therapeutic in the brain...

Research Terms

<Assay><Bioassay><Biological Assay><Brain><Brain Metastasis><Brain Neoplasia><Brain Neoplasms><Brain Nervous System><Brain Tumors><CD152><CD152 Antigen><CD152 Gene><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><CTLA 4><CTLA-4 Gene><CTLA4><CTLA4 gene><CTLA4-TM><Cancer Patient><Cancers><Cause of Death><Cell Body><Cell Communication><Cell Death><Cell Interaction><Cell-Extracellular Matrix><Cell-to-Cell Interaction><Cells><Characteristics><Clinical><Clinical Management><Clinical Trials><Cytotoxic T-Lymphocyte Protein 4><Cytotoxic T-Lymphocyte-Associated Antigen 4><Cytotoxic T-Lymphocyte-Associated Protein 4><Cytotoxic T-Lymphocyte-Associated Serine Esterase-4><Data><Dependence><Development><Disease><Disorder><Drug Screening><ECM><Encephalon><Extracellular Matrix><Fibroblasts><Future><Goals><Immune><Immune Targeting><Immune mediated therapy><Immunes><Immunocompetent><Immunologic Model><Immunologic Tests><Immunological Models><Immunological Tests><Immunologically Directed Therapy><Immunomodulation><Immunotherapy><Incubated><Laboratories><Ligands><Malignant Melanoma><Malignant Neoplasms><Malignant Tumor><Melanoma><Melanoma patient><Metastatic Neoplasm to the Brain><Metastatic Tumor to the Brain><Metastatic malignant neoplasm to brain><Methods><Modeling><Nivolumab><Opdivo><Operative Procedures><Operative Surgical Procedures><Organoids><PDX model><Parents><Patient derived xenograft><Patients><Phenotype><Pre-Clinical Model><Preclinical Models><Proteomics><Radiation><Receptor Protein><Sampling><Surgical><Surgical Interventions><Surgical Procedure><T-Cell Activation><T-Cell Subsets><T-Cells><T-Lymphocyte><T-Lymphocyte Subsets><T8 Cells><T8 Lymphocytes><Testing><Therapeutic><Therapeutic Studies><Therapy Research><Tumor Cell><activate T cells><biomarker identification><brain micrometastasis><check point inhibition><checkpoint inhibition><cost effective><cost efficient><cytotoxic T-lymphocyte antigen 4><developmental><exhaustion><experience><identification of biomarkers><identification of new biomarkers><immune check point inhibition><immune checkpoint inhibition><immune competent><immune microenvironment><immune modulation><immune regulation><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapies><immune-based treatments><immuno therapy><immunologic reactivity control><immunomodulatory><immunoregulation><immunoregulatory><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><improved><innovate><innovation><innovative><malignancy><marker identification><melanoma cancer model><melanoma model><melanoma tumor model><model development><model developments><necrocytosis><neoplasm/cancer><neoplastic cell><new drug treatments><new drugs><new pharmacological therapeutic><new therapeutics><new therapy><next generation therapeutics><novel drug treatments><novel drugs><novel pharmaco-therapeutic><novel pharmacological therapeutic><novel therapeutics><novel therapy><parent><patient derived xenograft model><patients suffering from melanoma><patients with melanoma><pre-clinical><precision medicine><precision-based medicine><preclinical><preservation><receptor><scRNA sequencing><scRNA-seq><single cell RNA-seq><single cell RNAseq><single cell expression profiling><single cell transcriptomic profiling><single-cell RNA sequencing><surgery><thymus derived lymphocyte><tumor><tumor immune microenvironment><tumor-immune system interactions><tumors in the brain>
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Norma Frizzell

UNIVERSITY OF SOUTH CAROLINA AT COLUMBIA, COLUMBIA, SC

Exploratory lead · 0/100
$74,500
FY 2024

Project Title

Developing Tools to Understand an Alternative Fate of Urate in Neurodegenerative Diseases

Grant Number:

5R03NS128819-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

3/1/2023

End Date:

2/28/2026

Project Abstract

ABSTRACT Urate is the salt form of uric acid predominantly found in the circulation and is considered a major plasma antioxidant. Low levels of serum urate at diagnosis are associated with accelerated disease progression and lower patient survival in several neurodegenerative diseases. For example, ...

Research Terms

<7S Gamma Globulin><Abscission><Acceleration><Address><Albumins><Amyotrophic Lateral Sclerosis><Amyotrophic Lateral Sclerosis Motor Neuron Disease><Antibodies><Antigenic Determinants><Antioxidants><Atrophic Arthritis><Binding Determinants><Blood Neutrophil><Blood Plasma><Blood Polymorphonuclear Neutrophil><Blood Serum><Cellular Stress><Cellular Stress Response><Chemicals><Circulation><Clinical><Collection><Corpus Striatum><Corpus striatum structure><Coupled><DAT dopamine transporter><Degenerative Neurologic Disorders><Detection><Diagnosis><Disease><Disease Progression><Disorder><Dyskinesia Syndromes><Epitopes><Equilibrium><Excision><Exposure to><Extirpation><Future><Gehrig's Disease><Generations><Goals><H2O2><Hemi-Myeloperoxidase><Hortega cell><Human><Hydrogen Peroxide><Hydroperoxide><IgG><Immunoglobulin G><In Vitro><Infiltration><Inflammation><Inflammatory><Inosine><Investigation><Investigators><L-Lysine><Libraries><Link><Location><Lou Gehrig Disease><Lymphatic cell><Lymphocyte><Lymphocytic><Lysine><Marrow Neutrophil><Measurement><Medulla Spinalis><Microglia><Modern Man><Movement Disorder Syndromes><Movement Disorders><Myeloperoxidase><Natural regeneration><Nature><Nerve Cells><Nerve Degeneration><Nerve Unit><Nervous System Degenerative Diseases><Neural Cell><Neural Degenerative Diseases><Neural degenerative Disorders><Neurocyte><Neurodegenerative Diseases><Neurodegenerative Disorders><Neurologic Degenerative Conditions><Neuron Degeneration><Neurons><Neutrophilic Granulocyte><Neutrophilic Leukocyte><Oxidative Stress><Paralysis Agitans><Parkinson><Parkinson Disease><Patient outcome><Patient-Centered Outcomes><Patient-Focused Outcomes><Patients><Peptides><Peroxidases><Peroxonitrite><Placebos><Plasma><Plasma Serum><Polymorphonuclear Cell><Polymorphonuclear Leukocytes><Polymorphonuclear Neutrophils><Population><Post-Translational Modification Protein/Amino Acid Biochemistry><Post-Translational Modifications><Post-Translational Protein Modification><Post-Translational Protein Processing><Posttranslational Modifications><Posttranslational Protein Processing><Pre-Clinical Model><Preclinical Models><Predisposition><Primary Parkinsonism><Process><Prognosis><Prognostic Marker><Protein Modification><Proteins><Proteomics><Regeneration><Removal><Research Personnel><Researchers><Reticuloendothelial System, Serum, Plasma><Rheumatoid Arthritis><Role><Serum><Sham Treatment><Sodium Chloride><Spinal Cord><Striate Body><Striatum><Superoxide Anion><Superoxide Radical><Superoxides><Supplementation><Surgical Removal><Susceptibility><Testing><Time><Treatment Efficacy><Trioxopurine><Urate><Uric Acid><Woman><adduct><balance><balance function><cell stress><cell type><clinical prognosis><degenerative diseases of motor and sensory neurons><degenerative neurological diseases><disease diagnosis><dopamine transporter><gitter cell><improved><intervention efficacy><lymph cell><men><mesoglia><microglial cell><microgliocyte><motor deficit><neural degeneration><neurodegeneration><neurodegenerative><neurodegenerative illness><neurological degeneration><neuronal><neuronal degeneration><neutrophil><novel><oxidation><oxidative damage><oxidative injury><patient oriented outcomes><perivascular glial cell><peroxynitrite><polyclonal antibody><prevent><preventing><prognostic ability><prognostic biomarker><prognostic power><prognostic utility><prognostic value><protein function><protein metabolite><protein structure><protein structures><proteins structure><regenerate><resection><rheumatic arthritis><salt><sham therapy><social role><striatal><therapeutic efficacy><therapy efficacy><tool>
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Somashekarappa Gowda Nanjappa

UNIVERSITY OF ILLINOIS AT URBANA-CHAMPAIGN, CHAMPAIGN, IL

Exploratory lead · 0/100
$73,603
FY 2025

Project Title

Generation and characterization of CD43-floxed mice for conditional ablation in hematopoietic cells and T cells in immunity against pulmonary fungal infections

Grant Number:

5R03AI182772-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/17/2024

End Date:

4/30/2026

Project Abstract

PROJECT SUMMARY Small Grant Program R03 proposal aims to generate CD43-floxed mice using the CRISPR-Cas9 technology and characterize the cell-specific antifungal functions of CD43 in hematopoietic and T cells using conditional CD43 KO mice. The preclinical model systems have been invaluable, providi...

Research Terms

<Ablation><Address><Adhesives><Adjuvant><Aldrich Syndrome><American Lung Association><American trypanosome><Apoptosis><Apoptosis Pathway><Attention><Autoimmune Status><Autoimmunity><Backcrossings><Bacterial Infections><Binding><Biologic Models><Biological Models><Biomedical Research><Blastomyces><Bone Marrow><Bone Marrow Reticuloendothelial System><CD 43 antigen><CD43 antigen><CD43 molecule><CD54 Antigens><CD62E Antigens><CD8 Cell><CD8 T cells><CD8 lymphocyte><CD8+ T cell><CD8+ T-Lymphocyte><CD8-Positive Lymphocytes><CD8-Positive T-Lymphocytes><COVID crisis><COVID epidemic><COVID pandemic><COVID-19 crisis><COVID-19 epidemic><COVID-19 era><COVID-19 global health crisis><COVID-19 global pandemic><COVID-19 health crisis><COVID-19 pandemic><COVID-19 period><COVID-19 public health crisis><COVID-19 years><CRISPR approach><CRISPR based approach><CRISPR method><CRISPR methodology><CRISPR technique><CRISPR technology><CRISPR tools><CRISPR-CAS-9><CRISPR-based method><CRISPR-based technique><CRISPR-based technology><CRISPR-based tool><CRISPR/CAS approach><CRISPR/Cas method><CRISPR/Cas technology><CRISPR/Cas9><CRISPR/Cas9 technology><Cancers><Candida><Carcinoma><Cas nuclease technology><Cell Adhesion Molecule E-Selectin><Cell Body><Cell Death><Cell Function><Cell Lineage><Cell Physiology><Cell Process><Cells><Cellular Function><Cellular Physiology><Cellular Process><Cessation of life><Chimera><Chimera organism><Clustered Regularly Interspaced Short Palindromic Repeats approach><Clustered Regularly Interspaced Short Palindromic Repeats method><Clustered Regularly Interspaced Short Palindromic Repeats methodology><Clustered Regularly Interspaced Short Palindromic Repeats technique><Clustered Regularly Interspaced Short Palindromic Repeats technology><Data><Death><E coli heat-labile enterotoxin><E coli heat-labile toxin><E-Selectin><E. coli heat-labile enterotoxin><E. coli heat-labile toxin><ELAM-1><Endothelial Adhesion Molecule 1><Endothelial Leukocyte Adhesion Molecule-1><Epithelial cancer><Escherichia coli heat-labile toxin><Funding><Fungal Vaccines><Fungus Diseases><GAL1><Galectin 1><Generations><Genus Mycobacterium><Glean><Grant><Habitats><Health><Hematopoietic><Histoplasma><Host Defense Mechanism><Human><ICAM-1><Immune><Immune mediated therapy><Immune response><Immunes><Immunity><Immunologically Directed Therapy><Immunotherapeutic agent><Immunotherapy><Infection><Influentials><Influenza A><Influenza A virus><Influenza Viruses Type A><Influenzavirus A><Innate Immune Response><Intercellular adhesion molecule 1><KO mice><Knock-out Mice><Knockout Mice><Knowledge><LECAM-2><LGALS1><LSGP><Leukocyte Endothelial Cell Adhesion Molecule 2><Ligands><LoxP-flanked allele><Lymphoid><Malaria><Malignant Cell><Malignant Epithelial Neoplasms><Malignant Epithelial Tumors><Malignant Neoplasms><Malignant Tumor><Medical><Medicine><Mice><Mice Mammals><Microbe><Model System><Modern Man><Molecular Interaction><Monilia><Mouse Strains><Murine><Mus><Mycobacterium><Mycoses><Myelogenous><Myeloid><Null Mouse><Orthomyxovirus Type A><Outcome><Output><Paludism><Parasitic infection><Patients><Pattern recognition receptor><Phase><Phenotype><Plasmodium Infections><Population><Pre-Clinical Model><Preclinical Models><Predisposition><Programmed Cell Death><Property><Public Health><Receptor Protein><Reproducibility><Research><Risk><Role><SARS-CoV-2 epidemic><SARS-CoV-2 global health crisis><SARS-CoV-2 global pandemic><SARS-CoV-2 pandemic><SARS-coronavirus-2 epidemic><SARS-coronavirus-2 pandemic><Severe Acute Respiratory Syndrome CoV 2 epidemic><Severe Acute Respiratory Syndrome CoV 2 pandemic><Severe acute respiratory syndrome coronavirus 2 epidemic><Severe acute respiratory syndrome coronavirus 2 pandemic><Siglec-1><Study models><Subcellular Process><Susceptibility><System><T cell response><T cruzi><T-Cells><T-Lymphocyte><T. cruzi><T8 Cells><T8 Lymphocytes><Therapeutic><Therapeutic Fungicides><Therapeutic Intervention><Transplantation><Trypanosoma cruzi><Type A Influenza><Vaccination><Vaccines><Viral Diseases><Virus Diseases><Wiskott syndrome><Wiskott-Aldrich Syndrome><Yeasts><adaptive immune response><anti-fungal><anti-fungal agents><anti-fungal drug><bacteria infection><bacterial disease><cancer cell><cell type><chimeras><climate change><climatic changes><coronavirus disease 2019 crisis><coronavirus disease 2019 epidemic><coronavirus disease 2019 global health crisis><coronavirus disease 2019 global pandemic><coronavirus disease 2019 health crisis><coronavirus disease 2019 pandemic><coronavirus disease 2019 public health crisis><coronavirus disease crisis><coronavirus disease epidemic><coronavirus disease pandemic><coronavirus disease-19 global pandemic><coronavirus disease-19 pandemic><customized therapy><customized treatment><design><designing><develop a vaccine><develop vaccines><development of a vaccine><discovery mining><eczema thromocytopenia diarrhea syndrome><eczema thromocytopenia immunodeficiency syndrome><eczema thromocytopenia syndrome><endothelial leukocyte adhesion molecule><epithelial carcinoma><experiment><experimental research><experimental study><experiments><floxed><floxed allele><fungal infection><fungal pneumonia><fungus infection><global climate change><gpL-115><gpL115><hemopoietic><host response><immune drugs><immune system response><immune therapeutic approach><immune therapeutic interventions><immune therapeutic regimens><immune therapeutic strategy><immune therapy><immune-based therapeutics><immune-based therapies><immune-based treatments><immuno therapy><immunologic therapeutics><immunological synapse><immunoresponse><immunotherapeutics><immunotherapy agent><individualized medicine><individualized patient treatment><individualized therapeutic strategy><individualized therapy><individualized treatment><infected with parasites><insight><intervention therapy><leukocyte sialoglycoprotein><leukosialin><literature mining><literature searching><lung pathogen><malignancy><microbial products><mortality><mouse model><murine model><necrocytosis><neoplasm/cancer><new vaccines><next generation vaccines><novel><novel vaccines><parasite infection><patient specific therapies><patient specific treatment><programs><pulmonary><pulmonary pathogen><receptor><respiratory><response><severe acute respiratory syndrome coronavirus 2 global health crisis><severe acute respiratory syndrome coronavirus 2 global pandemic><sialoadhesin><sialophorin><social role><tailored medical treatment><tailored therapy><tailored treatment><targeted drug therapy><targeted drug treatments><targeted therapeutic><targeted therapeutic agents><targeted therapy><targeted treatment><text mining><text searching><thymus derived lymphocyte><trafficking><transplant><tumor><unique treatment><vaccine development><vaccine efficacy><vaccine response><vaccine responsiveness><vaccine-induced response><vector><viral infection><virus infection><virus-induced disease>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

ANN LOUISE OLSON

UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR, OKLAHOMA CITY, OK

Exploratory lead · 0/100
$72,500
FY 2024

Project Title

Does age-dependent PFKFB3 down-regulation alter adipose tissue function

Grant Number:

5R03AG079945-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/1/2022

End Date:

11/30/2024

Project Abstract

Age is one of the major risk factors for the development of Type 2 diabetes, but the mechanisms underlying this risk are unknown. Diabetes risk is enhanced by obesity, a condition that increases through the lifespan. This has led us to hypothesize that increased diabetes risk with aging and obesity ...

Research Terms

<12-20 years old><6-Phosphofructo-1-kinase><6-Phosphofructo-2-kinase><6-Phosphofructokinase><6PF2K><ACRP30 protein><ATP-D-Fructose-6-phosphate 2-phosphotransferase><Abscission><Acceleration><Adipocytes><Adipose Cell><Adipose tissue><Adolescence><Adult-Onset Diabetes Mellitus><Age><Aging><Animals><Assay><Autoregulation><Bioassay><Biological Assay><Body Tissues><Caloric Restriction><Catecholamines><Cell Communication and Signaling><Cell Signaling><D-Glucose><Data><Development><Dextrose><Down-Regulation><Dysfunction><Endocrine Gland Secretion><Enzyme Gene><Enzymes><Erythrocyte/Hepatoma Glucose Transporter><Excision><Extirpation><Fasting><Fat Cells><Fatty Tissue><Fructose><Fructose-2,6-bisphosphatase><Fructose-2,6-bisphosphate 2-phosphatase><Fructose-6-P 1-Kinase><Fructose-6-phosphate 1-Phosphotransferase><Functional disorder><GLUT><GLUT 4 protein><GLUT1><GLUT4><GLUT4 gene><GLUT4 protein><Generalized Growth><Glucose><Glucose Transporter 1><Glycolysis><Goals><Grant><Growth><HK2><HK2 gene><HKII><HXK2><Homeostasis><Hormones><Human><Humulin R><Insulin><Intermediary Metabolism><Intervention><Intervention Strategies><Intracellular Communication and Signaling><Isoforms><Ketosis-Resistant Diabetes Mellitus><Kinases><Knock-out><Knockout><Laboratories><Levulose><Lipids><Lipocytes><Lipolysis><Maintenance><Mature Lipocyte><Mature fat cell><Maturity-Onset Diabetes Mellitus><Measurement><Mediating><Metabolic><Metabolic Diseases><Metabolic Disorder><Metabolic Processes><Metabolism><Modeling><Modern Man><Molecular><NIDDM><Non-Insulin Dependent Diabetes><Non-Insulin-Dependent Diabetes Mellitus><Noninsulin Dependent Diabetes><Noninsulin Dependent Diabetes Mellitus><Novolin R><Obesity><Obesity associated disease><Obesity related disease><Oxidation-Reduction><Pathway interactions><Peptides><Phosphatases><Phosphofructokinase-1><Phosphofructokinase-2><Phosphohydrolases><Phosphomonoesterases><Phosphoric Monoester Hydrolases><Phosphotransferase Gene><Phosphotransferases><Physiologic><Physiological><Physiological Homeostasis><Physiopathology><Play><Preparation><Prevalence><Production><Progenitor Cells><Protein Isoforms><Publishing><Pyruvate><R-Series Research Projects><R01 Mechanism><R01 Program><Redox><Regular Insulin><Regulation><Removal><Research><Research Grants><Research Project Grants><Research Projects><Risk><Risk Factors><Role><SLC2A1><SLC2A1 gene><Signal Transduction><Signal Transduction Systems><Signaling><Slow-Onset Diabetes Mellitus><Solute Carrier Family 2, Facilitated Glucose Transporter, Member 1><Source><Stable Diabetes Mellitus><Surgical Removal><Sympathins><T2 DM><T2D><T2DM><Testing><Therapeutic Hormone><Thesaurismosis><Tissue Growth><Tissues><Transphosphorylases><Type 2 Diabetes Mellitus><Type 2 diabetes><Type II Diabetes Mellitus><Type II diabetes><Up-Regulation><Upregulation><Weight Gain><Weight Increase><Work><adipocyte biology><adipocyte complement-related protein 30-kDa><adipocyte development><adipocyte differentiation><adipocyte, C1q and collagen domain containing protein><adipocytokines><adipokines><adiponectin><adipose><adiposity><adolescence (12-20)><adult onset diabetes><age associated><age associated alterations><age associated changes><age associated disease><age associated disorder><age associated impairment><age correlated><age correlated alterations><age correlated changes><age dependent><age dependent alterations><age dependent changes><age dependent disease><age dependent disorder><age dependent impairment><age linked><age related><age related alterations><age related changes><age related human disease><age specific><age specific alterations><age specific changes><age-related disease><age-related disorder><age-related impairment><aged><aged animal><aged animals><aged mice><aged mouse><ages><alterations with age><anaerobic glycolysis><animal old age><apM-1 protein><apM1 (adipose-specific) protein><biological signal transduction><blood glucose regulation><body weight gain><body weight increase><caloric restricted><calorically restricted><calorie restricted><calorie restriction><changes with age><corpulence><developmental><diabetes risk><disease risk><disorder risk><elderly animal><elderly mice><experiment><experimental research><experimental study><experiments><fasted><fasts><fat metabolism><feeding><fructose-2,6-diphosphatase><glucose RA><glucose control><glucose homeostasis><glucose metabolism><glucose production><glucose rate of appearance><glucose regulation><glucose uptake><glucose-regulated proteins><healthy aging><healthy human aging><insulin sensitivity><insulin signaling><insulin-responsive glucose transporter><interventional strategy><ketosis resistant diabetes><life span><lifespan><lipid metabolism><maturity onset diabetes><metabolism disorder><old animals><old mice><ontogeny><oxidation reduction reaction><pathophysiology><pathway><phosphohexokinase><postnatal><preparations><protein expression><resection><social role><stem cells><type 2 DM><type II DM><type two diabetes><uptake><white adipose tissue><wt gain><yellow adipose tissue>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

DAVID JESSE SANCHEZ

WESTERN UNIVERSITY OF HEALTH SCIENCES, POMONA, CA

Exploratory lead · 0/100
$71,500
FY 2024

Project Title

HIV Redirecting Innate Immunity by Vpu Targeting of JAK1

Grant Number:

5R03AI172631-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

6/20/2023

End Date:

5/31/2025

Project Abstract

Project Summary/Abstract It is well known that the pathogenesis of HIV is intricately linked to the immune system. For HIV to promote its replication and long-term infection HIV must also modulate cytokine signaling to manipulate the immune microenvironment HIV is existing in. In our previous work w...

Research Terms

<20S Catalytic Proteasome><20S Core Proteasome><20S Proteasome><20S Proteosome><AIDS Virus><Acquired Immune Deficiency Syndrome Virus><Acquired Immunodeficiency Syndrome Virus><Amino Acid Motifs><Biochemical><Blood Serum><CD4 Cells><CD4 Positive T Lymphocytes><CD4 T cells><CD4 helper T cell><CD4 lymphocyte><CD4+ T-Lymphocyte><CD4-Positive Lymphocytes><Cell Body><Cell Communication and Signaling><Cell Function><Cell Mediated Immunology><Cell Physiology><Cell Process><Cell Signaling><Cell-Mediated Immunity><Cells><Cellular Function><Cellular Immunity><Cellular Physiology><Cellular Process><Cellular biology><Cytokine Receptors><Cytokine Signal Transduction><Cytokine Signaling><Data><Dendritic Cells><Detection><Genes><Goals><HIV><HIV Infections><HTLV-III Infections><HTLV-III-LAV Infections><Human Immunodeficiency Viruses><Human T-Lymphotropic Virus Type III Infections><IFN><IFN-Gamma><IFN-g><IFN-γ><IFNG><IFNγ><Immune Interferon><Immune response><Immune system><Immunity><Immunological response><Infection><Innate Immune Response><Innate Immune System><Innate Immunity><Interferon Gamma><Interferon Type I><Interferon Type II><Interferons><Intracellular Communication and Signaling><JAK1><JAK1 gene><JAK1 protein><JAK1A><Jak1 kinase><Janus kinase 1><LAV-HTLV-III><Link><Lymphadenopathy-Associated Virus><Lysosomes><Macropain><Macroxyproteinase><Maps><Mediating><Methods><Multicatalytic Proteinase><Mutation Analysis><Names><Native Immunity><Natural Immunity><Non-Specific Immunity><Nonspecific Immunity><Outcome><Pathogenesis><Patients><Peptide Domain><Persons><Phenotype><Phosphorylation><Production><Prosome><Proteasome><Proteasome Endopeptidase Complex><Protein Domains><Protein Motifs><Protein Phosphorylation><Proteins><Proteosome><R-Series Research Projects><R01 Mechanism><R01 Program><Refractory><Research Grants><Research Project Grants><Research Projects><STAT1><STAT1 gene><STAT91><Serum><Signal Transduction><Signal Transduction Systems><Signaling><Subcellular Process><System><T-Cells><T-Lymphocyte><T4 Cells><T4 Lymphocytes><Techniques><Tertiary Protein Structure><Tyrosine-Protein Kinase JAK1><Ubiquitilation><Ubiquitination><Ubiquitinoylation><Veiled Cells><Viral><Viral Diseases><Virus><Virus Diseases><Virus Replication><Virus-HIV><Work><adaptive immunity><anti-viral immunity><antiviral immunity><arm><biological signal transduction><cell biology><cellular targeting><cytokine><domain mapping><experience><host response><immune clearance><immune elimination><immune microenvironment><immune system response><immunoresponse><immunosuppressive microenvironment><immunosuppressive tumor microenvironment><insight><lFN-Gamma><multicatalytic endopeptidase complex><name><named><naming><response><thymus derived lymphocyte><tumor immune microenvironment><tumor-immune system interactions><ubiquination><ubiquitin conjugation><viral infection><viral multiplication><viral replication><virus infection><virus multiplication><virus-induced disease><vpu Protein>
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Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Ian Marriott

UNIVERSITY OF NORTH CAROLINA CHARLOTTE, CHARLOTTE, NC

Exploratory lead · 0/100
$70,337
FY 2025

Project Title

Type I interferon responses of bone cells to Staphylococcus aureus: A pilot study

Grant Number:

5R03AI176300-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

11/13/2023

End Date:

10/31/2025

Project Abstract

PROJECT SUMMARY Bone disorders such as osteomyelitis that result from bacterial infection are associated with severe inflammation and progressive bone loss. Staphylococcus aureus is the most common causative agent of osteomyelitis and the incidence and severity of staphylococcal osteomyelitis appear...

Research Terms

<(IFN) α><(IFN)-α><(IFN)α><Affect><Agonist><Alferon><Antibiotic Agents><Antibiotic Drugs><Antibiotics><Autocrine Systems><Autoregulation><Bacteria><Bacterial Antibiotic Resistance><Bacterial Infections><Biological Response Modifiers><Biomodulators><Blood leukocyte><Bone Diseases><Bone Infection><Bone Resorption><Bone Tissue><Bone remodeling><Cell Body><Cell Culture Techniques><Cell Isolation><Cell Segregation><Cell Separation><Cell Separation Technology><Cells><Chemoattractants><Chemotactic Factors><Chemotaxins><Chronic><Clinical><Cytoplasm><Data><Diagnosis><Endogenous Interferon Beta><Fibroblast Interferon><Future><Genes><Genus staphylococcus><Homeostasis><IFN><IFN Alpha><IFN α><IFN-α><IFN-β><IFNa><IFNb><IFNα><Immune Mediators><Immune Mediators/Modulators><Immune response><Incidence><Infection><Inflammation><Inflammation Mediators><Inflammatory><Interferon Alfa-n3><Interferon Type I><Interferon-α><Interferon-β><Interferons><Invaded><Leukocyte Interferon><Leukocytes><Leukocytes Reticuloendothelial System><Lymphoblast Interferon><Lymphoblastoid Interferon><Marrow leukocyte><Mediating><Mediator><Mice><Mice Mammals><Microbial Biofilms><Miscellaneous Antibiotic><Murine><Mus><Natural Interferon Beta><Natural human interferon beta><OPGL><Osteoblasts><Osteoclastic Bone Loss><Osteoclasts><Osteocytes><Osteolytic><Osteomyelitis><Physiological Homeostasis><Pilot Projects><Play><Predisposition><Production><Prophylactic treatment><Prophylaxis><R-Series Research Projects><R01 Mechanism><R01 Program><RANKL><Recurrence><Recurrent><Refractory><Regulation><Reporting><Research Grants><Research Project Grants><Research Projects><Role><S aureus><S. aureus><S. aureus infection><Severities><Site><Source><Staph aureus><Staph aureus infection><Staphylococcal Infections><Staphylococcus><Staphylococcus aureus><Staphylococcus aureus infection><Staphylococcus infection><Susceptibility><TLR3><TLR3 gene><TNFSF11><TNFSF11 gene><Testing><Toll-Like Receptor 3><Viral><White Blood Cells><White Cell><antibiotic resistant bacteria><autocrine><bacteria infection><bacteria pathogen><bacterial antibiotic resistant><bacterial disease><bacterial pathogen><bacterial resistance to antibiotic><biofilm><bone><bone cell><bone disorder><bone loss><bone resorbing activity><cell culture><cell cultures><cell sorting><complement chemotactic factor><cytokine><hRANKL2><host response><immune system response><immunoresponse><improved><infected with S. aureus><infected with Staph aureus><infected with Staphylococcus aureus><infection recurrence><inflammatory bone loss><inflammatory mediator><inhibitor><osteoclastogenesis><osteogenic><paracrine><pathogenic bacteria><pilot study><recruit><recurrent infection><recurring infection><response><sOdf><sensor><social role><staph infections><treatment strategy><white blood cell><white blood corpuscle>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Brian Kalish

HOSPITAL FOR SICK CHLDRN (TORONTO), TORONTO, ON, CANADA

Exploratory lead · 0/100
$54,000
FY 2024

Project Title

Discovery of Novel Autism-Associated Variation in Brain Miniproteins

Grant Number:

5R03MH131958-02

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

12/2/2022

End Date:

11/30/2024

Project Abstract

PROJECT SUMMARY This R03 proposal describes a two-year research plan focused on the investigation of previously unannotated miniproteins to the genetic etiology of Autism Spectrum Disorder (ASD). Rare inherited and de novo genetic variants are important causes of ASD, but explain the etiology in onl...

Research Terms

<0-11 years old><3-D structure><3-dimensional structure><3D structure><ASD><Address><Affect><Amino Acids><Atlases><Autism><Autistic Disorder><Base Sequence><Bio-Informatics><Bioinformatics><Biology><Brain><Brain Nervous System><Calcium Ion Signaling><Calcium Signaling><Causality><Cell Differentiation><Cell Differentiation process><Child><Child Youth><Children (0-21)><Clinical><Clinical Evaluation><Clinical Testing><Code><Coding System><Collection><Complex Genetic Trait><Computer Models><Computerized Models><Data><Data Set><Development><Disease><Disorder><Early Infantile Autism><Encephalon><Etiology><Family><Foundations><Functional RNA><Future><GWA study><GWAS><Gene variant><Genes><Genetic><Genetic Diseases><Genetic Predisposition><Genetic Predisposition to Disease><Genetic Susceptibility><Genetic analyses><Genetic propensity><Genome><Genomics><Goals><Grant><Hereditary><Heritability><Human><Impairment><Individual><Infantile Autism><Infrastructure><Inherited><Inherited Predisposition><Inherited Susceptibility><Investigation><Kanner's Syndrome><Knowledge><Modeling><Modern Man><Molecular><Nerve Cells><Nerve Unit><Nervous System><Neural Cell><Neurobiology><Neurocyte><Neurodevelopmental Disorder><Neurologic><Neurologic Body System><Neurologic Organ System><Neurological><Neurological Development Disorder><Neurons><Neurosciences><Non-Coding><Non-Coding RNA><Non-translated RNA><Noncoding RNA><Nontranslated RNA><Nucleotide Sequence><Nucleotides><ORFs><Open Reading Frames><Phenotype><Protein Analysis><Protein Coding Region><Protein Truncation><Proteins><RNA Binding><RNA bound><Regulation><Research><Ribo-seq><Role><Social Interaction><Specificity><Translating><Translations><Transmission><Twin Studies><United States><Untranslated RNA><Variant><Variation><Work><allele variant><allelic variant><aminoacid><autism spectral disorder><autism spectrum disorder><autistic spectrum disorder><brain tissue><causation><cell type><cellular differentiation><clinical test><cohort><computational modeling><computational models><computational pipelines><computer based models><computerized modeling><de novo mutation><de novo variant><developmental><disease causation><disease risk><disorder risk><dosage><entire genome><experiment><experimental research><experimental study><experiments><full genome><genetic analysis><genetic architecture><genetic condition><genetic disorder><genetic etiology><genetic mechanism of disease><genetic variant><genetic vulnerability><genetically predisposed><genome annotation><genome sequencing><genome wide association><genome wide association scan><genome wide association studies><genome wide association study><genomewide association scan><genomewide association studies><genomewide association study><genomic variant><human disease><indel><insertion-deletion><insertion-deletion mutation><insertion/deletion><insertion/deletion mutation><interest><kids><large data sets><large datasets><life span><lifespan><mRNA Translation><mitochondrial metabolism><neurobiological><neurodevelopmental disease><neuronal><neuropsychiatric disease><neuropsychiatric disorder><noncoding><novel><nucleic acid sequence><polygenic risk score><programs><repetitive behavior><research clinical testing><ribosome footprint profiling><ribosome profiling><social communication><social role><three dimensional structure><trait><translation><translatome><transmission process><whole genome><whole genome association analysis><whole genome association studies><whole genome association study><youngster>
View Full Project Details on NIH Reporter
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Subham Dasgupta

CLEMSON UNIVERSITY, CLEMSON, SC

Exploratory lead · 0/100
$39,938
FY 2024

Project Title

Uncovering the Role of Histone Acetylation in Tetrabromobisphenol A-induced Developmental Toxicity during Zygotic Genome Activation

Grant Number:

3R03ES036327-01S1

Activity Code:

R03

Mechanism:

Non-SBIR/STTR

Agency:

NIH

Start Date:

4/1/2024

End Date:

3/31/2025

Project Abstract

Project abstract: The overall goal of this diversity supplement is to provide Mr. Rojas with a niche research area in addition to the parent R03 and facilitate his career development within biomedical sciences. While the parent grant focuses on the impacts of Tetrabromobisphenol A (TBBPA) on materna...

Research Terms

<Acetylation><Acetyltransferase><Area><Assay><Bioassay><Biological Assay><Cloning><Coupled><DNA Molecular Biology><Development><Developmental Delay><Developmental Delay Disorders><Embryo><Embryonic><Genes><Genome><Goals><Grant><Histone Acetylation><Injections><Laboratories><Lead><Learning><Link><Mediating><Mentors><Messenger RNA><Microinjections><Molecular><Molecular Biology><Molecular Toxicology><N-terminal><NH2-terminal><Parents><Pb element><Peptides><Phenotype><Proteome><Research><Role><Science><Specific Child Development Disorders><Techniques><Testing><Toxic effect><Toxicities><Training><Writing><career><career development><career fair><career networking><conference><convention><data integration><developmental><developmental toxicity><heavy metal Pb><heavy metal lead><mRNA><parent><parent grant><professional networking><protein purification><social role><speed networking><summit><symposia><symposium><tetrabromobisphenol A>
View Full Project Details on NIH Reporter
Public NIH records usually do not include a direct email address. For outreach, verify the investigator through their institution profile, lab website, recent publications, or official NIH project page.

Search NIH grants by PI name

Looking for a specific principal investigator? The keyword search above looks up funded projects by topic. To search NIH grants by PI name (last name, first + last name, or partial name) and see every active and recent NIH award for that researcher, use the dedicated PI Funding Status tool.

How to Use PI Funding Data for Career Decisions

Finding the right principal investigator is one of the most important decisions in an academic career. Whether you are a postdoc looking for a mentor, a graduate student choosing a rotation lab, or a collaborator seeking a co-PI, NIH funding data provides objective signals about which investigators have active research programs and resources to support new team members.

A PI with a recently awarded R01 or equivalent grant is more likely to have budget for new personnel than one whose funding ended two years ago. The activity code tells you the type of grant: R01 and R35 awards typically support multiple lab members, while K-series awards are individual career development grants that may not fund additional positions. Understanding these distinctions helps you interpret search results accurately.

Look beyond the dollar amount. A $500,000 per year R01 at a high-cost institution may support fewer positions than a $300,000 award at a university with lower overhead rates. The project abstract and public health relevance statement reveal whether the PI's research direction aligns with your interests and expertise.

Understanding PI Grant Portfolios

A PI's grant portfolio reveals more than individual awards. Investigators with multiple active grants often run larger labs with more diverse projects, which can mean more opportunities for trainees. However, a PI with a single well-funded grant may offer more focused mentorship and a clearer path to publications.

Multi-PI grants (those with more than one principal investigator listed) indicate collaborative research and may involve trainees from multiple institutions. These can be excellent opportunities for interdisciplinary training but may also mean split attention from any single mentor.

Pay attention to the timing of awards. A PI who just received a new five-year R01 is in a different position than one whose grant ends next year. New awards often correspond to lab expansion and active recruiting, making them ideal targets for job seekers. The start and end dates shown in each result help you assess this timing.

Best Practices for Contacting Funded PIs

Once you identify a promising PI through this tool, the next step is outreach. NIH public records do not include email addresses, but you can usually find contact information through the PI's institutional profile page, lab website, or recent publications. Google Scholar, PubMed, and the PI's department website are reliable starting points.

When reaching out, reference the specific grant that caught your attention. Mentioning the project title and explaining how your skills relate to the funded work shows that you have done your homework. Keep your initial message concise: introduce yourself, explain your interest, attach your CV, and ask whether they anticipate openings.

Timing matters. Contacting a PI within the first year of a new award is ideal, as this is when they are most likely to be recruiting. If you find multiple promising PIs in the same field, prioritize those with the most recent award notices and activity codes that support trainee positions such as R01, U01, or P-series grants.

Frequently Asked Questions About PI Search

What does the opportunity score mean?

The opportunity score is a heuristic that combines award recency, funding amount, activity code type, and project characteristics to estimate how actionable a result might be for job seekers or collaborators. Higher scores suggest stronger signals, but always verify by reading the abstract and checking the PI's current lab page.

Why can't I find a PI I know has funding?

Name variations are the most common cause. Try searching with just the last name, or use different formats like "Smith, John" versus "John Smith." Some PIs also publish under different name variations or may have awards under a previous institutional affiliation.

Does this tool show all NIH-funded PIs?

The tool searches NIH RePORTER data for the keyword and year range you specify. It returns PIs whose funded projects match your search terms. PIs with grants in unrelated areas or whose projects use different terminology will not appear in keyword-filtered results.

What is the difference between "Likely hiring" and "Training-friendly" filters?

"Likely hiring" flags PIs with large new awards or activity codes typically associated with lab expansion. "Training-friendly" identifies awards that include training components or are at institutions known for postdoctoral programs. Both are heuristic filters to help prioritize your outreach.

How to use this well

Start broad, then narrow. Search a field first, then refine by timeframe once you understand who is currently active.

After you find a promising PI, cross-check them in Check PI Funding and review their institution, mechanism type, and project abstracts before reaching out.

What a match means

A result means the keyword appears relevant to the funded project data we searched. It does not guarantee the PI is hiring or that the grant is still active.

Use the abstract, award year, mechanism, and organization context to decide whether the record is strategically relevant.

Data limits

NIH records can lag, institutional names can vary, and some investigators publish or file awards under multiple name formats.

For details on source coverage and refresh cadence, read Data & Methodology.

Related guides

Companion guides for turning a PI search result into useful outreach or a job lead.

Career Guide8 min read

How Postdocs Can Find PIs with New NIH Funding

A tactical job-search guide for identifying recently funded labs, judging fit, and timing outreach to principal investigators.

Read guide
Career Guide7 min read

How to Contact a PI: Finding Emails and Crafting the Perfect Message

Emailing strategies, outreach examples, and a workflow for turning NIH funding signals into focused PI conversations.

Read guide
Career Guide10 min read

How to Read a New NIH Award Like a Hiring Signal

A practical framework for using newly funded NIH awards to judge whether a lab may be expanding, hiring, or worth contacting now.

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Funding Strategy16 min read

How to Find NIH Funding Opportunities: A Step-by-Step Guide for Researchers

Learn how to find NIH funding opportunities using the NIH Guide, Grants.gov, FOAs, NIH RePORTER, and program officer outreach.

Read guide

Recently Funded Labs in Trending Areas

Principal investigators who received NIH awards in the last 90 days, organized by research area. Use this as a starting point for postdoc searches, collaborator outreach, or competitor scans. Counts and labs refresh daily.

Alzheimer's disease

Neurodegeneration, biomarkers, and disease-modifying therapies.

  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $101,153 · awarded Feb 25, 2026 · 3U01AG084514-01A1S1
  • Carlos Cruchaga — WASHINGTON UNIVERSITY, MO
    CONGAS: "Caribbean Omics 'N' Genomics for Alzheimer Study"
    $3,086,339 · awarded Feb 19, 2026 · 1U01AG084514-01A1
  • HARALD SONTHEIMER — UNIVERSITY OF VIRGINIA, VA
    Extracellular matrix and memory impairments in Alzheimer disease
    $709,066 · awarded Apr 7, 2026 · 5R01AG085359-03
  • Keith Josephs — MAYO CLINIC ROCHESTER, MN
    The neurobiology of two distinct subtypes of neurodegenerative apraxia of speech: phenotypes of Alzheimer disease related 4-repeat tauopathies
    $643,670 · awarded Apr 1, 2026 · 5R01DC014942-09
  • DMITRIY YABLONSKIY — WASHINGTON UNIVERSITY, MO
    Deep-Learning-Augmented Quantitative Gradient Recalled Echo (DLA-qGRE) MRI for in vivo Clinical Evaluation of Brain Microstructural Neurodegeneration in Alzheimer Disease
    $661,985 · awarded Mar 3, 2026 · 4R01AG082030-02
Search more PIs in Alzheimer's disease →

CRISPR & gene editing

Therapeutic gene editing, base editing, and prime editing.

  • Changchun Liu — UNIVERSITY OF CONNECTICUT SCH OF MED/DNT, CT
    Asymmetric CRISPR Approach for Nucleic Acid Quantification
    $643,849 · awarded Mar 30, 2026 · 2R01EB023607-06A1
  • William Pu — BOSTON CHILDREN'S HOSPITAL, MA
    A modular system for murine CRISPR genome and epigenome editing
    $267,000 · awarded Mar 27, 2026 · 5R21OD037909-02
  • Naama Aviram — SLOAN-KETTERING INST CAN RESEARCH, NY
    Molecular mechanisms of memory formation and tolerance in CRISPR-Cas systems
    $249,000 · awarded Apr 2, 2026 · 5R00GM148720-04
  • Mats Ljungman — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Precision targeting of bladder cancer using CRISPR
    $582,849 · awarded Feb 17, 2026 · 5R01CA285730-03
  • Shannon Miller — SCRIPPS RESEARCH INSTITUTE, THE, CA
    Development of potent and safe CRISPR tools for in vivo gene editing using directed evolution
    $230,000 · awarded May 5, 2026 · 5R21EB036298-03
Search more PIs in CRISPR & gene editing →

Cancer immunotherapy

Checkpoint inhibitors, CAR-T, TIL therapy, and beyond.

  • TERRY SHEPPARD — KEYSTONE SYMPOSIA, CO
    Cancer Immunotherapy: Basic Mechanisms Informing Clinical Applications & Combinations
    $5,000 · awarded Mar 3, 2026 · 1R13CA310704-01
  • Veronika Fedirko — UNIVERSITY OF TX MD ANDERSON CAN CTR, TX
    Gut Microbiome and Cancer Immunotherapy Outcomes in Advanced Renal Cell Carcinoma
    $927,329 · awarded Mar 3, 2026 · 5R01CA255322-05
  • Yuwen Zhu — UNIVERSITY OF COLORADO DENVER, CO
    The GPR171 pathway in cancer immunotherapy
    $355,706 · awarded Apr 2, 2026 · 5R01CA279398-04
  • ANDREW WIEMER — UNIVERSITY OF CONNECTICUT STORRS, CT
    Synthesis and evaluation of BTN3A1 ligands for cancer immunotherapy
    $374,171 · awarded May 1, 2026 · 5R01CA266138-05
  • Wei Hu — YALE UNIVERSITY, CT
    Novel Treg inactivating approach for cancer immunotherapy via targeted protein degradation
    $482,312 · awarded Apr 6, 2026 · 1R01CA295942-01A1
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GLP-1 & metabolic disease

Diabetes, obesity, and weight-loss therapeutic mechanisms.

  • ZHIPING PANG — RUTGERS BIOMEDICAL AND HEALTH SCIENCES, NJ
    Synaptic and circuit mechanisms of central GLP-1 signaling in energy balance
    $479,051 · awarded Apr 23, 2026 · 5R01DK131452-05
  • Madhusmita Misra — UNIVERSITY OF VIRGINIA, VA
    Bone metabolism in adolescents undergoing GLP-1 receptor agonist therapy
    $471,776 · awarded Apr 24, 2026 · 5R01HD118635-07
  • STEVEN SCHWENDEMAN — UNIVERSITY OF MICHIGAN AT ANN ARBOR, MI
    Remote Loading of Melanocortin and GLP-1 Peptides in Polymers for Treatment of Obesity
    $231,000 · awarded Apr 17, 2026 · 1R56DK141545-01A1
  • Jessica Barson — DREXEL UNIVERSITY, PA
    Suppression of ethanol dependence-induced maladaptive appetitive and consummatory behavior by the GLP-1 system
    $564,306 · awarded May 5, 2026 · 1R01AA031732-01A1
  • MICHAEL CAMILLERI — MAYO CLINIC ROCHESTER, MN
    A Randomized, placebo-controlled trial of the effects of Long-Acting GLP-1 or Dual Incretin (GLP-1 and GIP) Modulation on Gastrointestinal Functions and Relationship to Weight Loss
    $322,800 · awarded Apr 9, 2026 · 5R01DK142606-02
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Long COVID

Post-acute sequelae and chronic infection-driven illness.

  • Alexei Tumanov — UNIVERSITY OF TEXAS HLTH SCIENCE CENTER, TX
    Lymphotoxin-dependent control of long COVID
    $234,715 · awarded Feb 13, 2026 · 1R21AI185790-01A1
  • Amal Amer — OHIO STATE UNIVERSITY, OH
    Role of the Non-canonical Inflammasome in SARS-CoV-2-mediated Pathology and Coagulopathy
    $2,974,582 · awarded Apr 21, 2026 · 5P01AI175399-03
  • Alba Azola — JOHNS HOPKINS UNIVERSITY, MD
    Blood-Brain Barrier Integrity and Immune Dynamics in Neuropsychiatric Sequelae of Post-SARS-CoV-2 onset ME/CFS versus Pre-Pandemic ME/CFS Patients
    $633,378 · awarded Apr 17, 2026 · 1R01NS147100-01
  • DANIELLE REED — MONELL CHEMICAL SENSES CENTER, PA
    Inflammation and chemosensory loss
    $2,654,249 · awarded Feb 26, 2026 · 1P50DC022549-01A1
  • Jarred Younger — UNIVERSITY OF ALABAMA AT BIRMINGHAM, AL
    Low-dose naltrexone (LDN) for the treatment of Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS)
    $556,686 · awarded Mar 6, 2026 · 1UG3NS141843-01A1
Search more PIs in Long COVID →